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LLM-Enzyme-Kinetics-Archive-LLENKA

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train · 35.6k rows

Enzyme stringlengths 4 59	Organism stringlengths 1 70	Substrate stringlengths 1 86	km float64 0 1.4M ⌀	Unit_Km stringclasses 65 values	Kcat stringlengths 1 16	Unit_Kcat stringclasses 134 values	Kcat/Km stringlengths 1 21	Unit_Kcat/Km stringclasses 335 values	Commentary[Temp] stringclasses 165 values	Commentary[pH] stringclasses 225 values	Commentary[Mutant] stringlengths 1 93	Commentary[Cosubstrate] stringlengths 1 89	pubmed id float64 1.5M 35.5M ⌀
SSβG	Sulfolobus solfataricus	4-MUGal	0.47	mM	5.4	s^-1	11	s^-1mM^-1	80°C	6.5	E432C		11,749,955
SSβG	Sulfolobus solfataricus	4-MUGal	2.2	mM	14	s^-1	6.3	s^-1mM^-1	80°C	6.5	W433C		11,749,955
SSβG	Sulfolobus solfataricus	4-MUGal	0.083	mM	94	s^-1	1130	s^-1mM^-1	80°C	6.5	M439C		11,749,955
SSβG	Sulfolobus solfataricus	4-MUFuc	0.011	mM	80	s^-1	7300	s^-1mM^-1	80°C	6.5	WT		11,749,955
SSβG	Sulfolobus solfataricus	4-MUFuc	0.34	mM	18	s^-1	53	s^-1mM^-1	80°C	6.5	E432C		11,749,955
SSβG	Sulfolobus solfataricus	4-MUFuc	0.41	mM	31	s^-1	76	s^-1mM^-1	80°C	6.5	W433C		11,749,955
SSβG	Sulfolobus solfataricus	4-MUFuc	0.023	mM	91	s^-1	4000	s^-1mM^-1	80°C	6.5	M439C		11,749,955
SSβG	Sulfolobus solfataricus	4-MUMan	0.036	mM	1.8	s^-1	50	s^-1mM^-1	80°C	6.5	WT		11,749,955
SSβG	Sulfolobus solfataricus	4-MUMan	0.9	mM	2.8	s^-1	3.2	s^-1mM^-1	80°C	6.5	E432C		11,749,955
SSβG	Sulfolobus solfataricus	4-MUMan	0.18	mM	0.92	s^-1	5.1	s^-1mM^-1	80°C	6.5	W433C		11,749,955
SSβG	Sulfolobus solfataricus	4-MUMan	0.042	mM	2.3	s^-1	53	s^-1mM^-1	80°C	6.5	M439C		11,749,955
SSβG	Sulfolobus solfataricus	4-MUXyl	0.13	mM	3.8	s^-1	30	s^-1mM^-1	80°C	6.5	WT		11,749,955
SSβG	Sulfolobus solfataricus	4-MUXyl	1.26	mM	2.8	s^-1	2.2	s^-1mM^-1	80°C	6.5	E432C		11,749,955
SSβG	Sulfolobus solfataricus	4-MUXyl	0.59	mM	1.5	s^-1	2.5	s^-1mM^-1	80°C	6.5	W433C		11,749,955
SSβG	Sulfolobus solfataricus	4-MUXyl	0.068	mM	9.3	s^-1	136	s^-1mM^-1	80°C	6.5	M439C		11,749,955
SSβG	Sulfolobus solfataricus	4-MUGlcA	1.3	mM	0.81	s^-1	0.60	s^-1mM^-1	80°C	6.5	WT		11,749,955
TrpA	Thermotoga maritima	IGP	1.62	mM	0.174	s^-1	0.11	mM^-1s^-1	80°C	7.5		180 mM KCl, 40 µM PLP, 20 mM arsenate, 6 mM NAD^+	11,756,459
TrpA	Thermotoga maritima	IGP	0.19	mM	5.6	s^-1	29.5	mM^-1s^-1	80°C	7.5		180 mM KCl, 40 µM PLP, 20 mM arsenate, 6 mM NAD^+	11,756,459
TrpA	Escherichia coli	IGP	0.48	mM	0.0016	s^-1	3.3 × 10^-3	mM^-1s^-1	25°C	7.8		1 mM EDTA, 0.2 mM DTT	11,756,459
TrpA	Escherichia coli	IGP	0.14	mM	0.067	s^-1	0.48	mM^-1s^-1	25°C	7.6		40 µM PLP, 5 mM EDTA, 0.2 mM DTT, 10 mM arsenate, 1 mM NAD^+	11,756,459
TrpB1	Thermotoga maritima	IND	0.04	mM	4.2	s^-1	100	mM^-1s^-1	80°C	7.5		180 mM KCl, 40 µM PLP	11,756,459
TrpB1	Thermotoga maritima	Ser	110	mM	3.8	s^-1	0.034	mM^-1s^-1	80°C	7.5		180 mM KCl, 40 µM PLP	11,756,459
TrpB1	Thermotoga maritima	IND	0.025	mM	10	s^-1	400	mM^-1s^-1	80°C	7.5		180 mM KCl, 40 µM PLP	11,756,459
TrpB1	Thermotoga maritima	Ser	3.7	mM	8	s^-1	2.2	mM^-1s^-1	80°C	7.5		180 mM KCl, 40 µM PLP	11,756,459
TrpB	Escherichia coli	IND	0.014	mM	0.28	s^-1	20	mM^-1s^-1	25°C	7.5		40 µM PLP, 5 mM EDTA, 0.2 mM DTT	11,756,459
TrpB	Escherichia coli	Ser	0.95	mM	0.18	s^-1	0.19	mM^-1s^-1	25°C	7.5		40 µM PLP, 5 mM EDTA, 0.2 mM DTT	11,756,459
TrpB	Escherichia coli	IND	0.015	mM	5.3	s^-1	408	mM^-1s^-1	25°C	7.5		40 µM PLP, 5 mM EDTA, 0.2 mM DTT	11,756,459
TrpB	Escherichia coli	Ser	0.43	mM	5.3	s^-1	12	mM^-1s^-1	25°C	7.5		40 µM PLP, 5 mM EDTA, 0.2 mM DTT	11,756,459
TrpB2	Thermotoga maritima	IND	0.00077	mM	0.46	s^-1	0.6	µM^-1s^-1	80°C	7.5		180 mM KCl, 40 µM PLP	11,756,459
TrpB2	Thermotoga maritima	Ser	50.2	mM	0.44	s^-1	0.0088	mM^-1s^-1	80°C	7.5		180 mM KCl, 40 µM PLP	11,756,459
TrpAB	Thermotoga maritima	IGP	0.19	mM	5.6	s^-1	29.5	mM^-1s^-1	80°C	7.5		180 mM KCl, 40 µM PLP, 20 mM arsenate, 6 mM NAD^+	11,756,459
TrpAB	Thermotoga maritima	Ser	3.7	mM	8	s^-1	2.2	mM^-1s^-1	80°C	7.5		180 mM KCl, 40 µM PLP	11,756,459
TrpAB	Thermotoga maritima	IGP	0.016	mM	4.14	s^-1	260	mM^-1s^-1	80°C	7.5		180 mM KCl, 40 µM PLP, 20 mM arsenate, 6 mM NAD^+	11,756,459
TrpAB	Thermotoga maritima	Ser	0.13	mM	4.26	s^-1	34	mM^-1s^-1	80°C	7.5		180 mM KCl, 40 µM PLP, 20 mM arsenate, 6 mM NAD^+	11,756,459
TrpAB	Escherichia coli	IGP	0.14	mM	0.067	s^-1	0.48	mM^-1s^-1	25°C	7.6		40 µM PLP, 5 mM EDTA, 0.2 mM DTT	11,756,459
TrpAB	Escherichia coli	Ser	0.43	mM	5.3	s^-1	12	mM^-1s^-1	25°C	7.6		40 µM PLP, 5 mM EDTA, 0.2 mM DTT	11,756,459
TrpAB	Escherichia coli	IGP	0.069	mM	1.4	s^-1	20	mM^-1s^-1	25°C	7.6		40 µM PLP, 5 mM EDTA, 0.2 mM DTT	11,756,459
ProRS	Methanococcus jannaschii	Proline	0.03	µM	0.58	s^-1	19.3	s^-1µM^-1	65°C		Native tRNA^Pro		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	0.81	µM	0.094	s^-1	0.12	s^-1µM^-1	65°C		Native tRNA^Cys		11,827,467
ProRS	Methanococcus jannaschii	Proline	0.22	µM	1.08	s^-1	4.90	s^-1µM^-1	65°C		Transcript^Pro/UGG		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	0.31	µM	0.075	s^-1	0.24	s^-1µM^-1	65°C		Transcript^Pro/UGG		11,827,467
ProRS	Methanococcus jannaschii	Proline	0.39	µM	1.41	s^-1	3.61	s^-1µM^-1	65°C		Transcript^Pro/GGG		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	0.55	µM	0.168	s^-1	0.30	s^-1µM^-1	65°C		Transcript^Pro/GGG		11,827,467
ProRS	Methanococcus jannaschii	Proline	0.19	µM	0.49	s^-1	2.51	s^-1µM^-1	65°C		Chimera^Pro/UGG		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	0.82	µM	0.011	s^-1	0.013	s^-1µM^-1	65°C		Chimera^Pro/UGG		11,827,467
ProRS	Methanococcus jannaschii	Proline	0.22	µM	1.08	s^-1	4.90	s^-1µM^-1	65°C		WT transcript of tRNA^Pro/UGG		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	0.31	µM	0.075	s^-1	0.24	s^-1µM^-1	65°C		WT transcript of tRNA^Pro/UGG		11,827,467
ProRS	Methanococcus jannaschii	Proline	null				0.50		65°C		A73C		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	null				0.55		65°C		A73C		11,827,467
ProRS	Methanococcus jannaschii	Proline	null				0.08		65°C		A73G		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	null				0.29		65°C		A73G		11,827,467
ProRS	Methanococcus jannaschii	Proline	null				0.17		65°C		A73U		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	null				0.32		65°C		A73U		11,827,467
ProRS	Methanococcus jannaschii	Proline	null				1.00		65°C		U34G		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	null				0.88		65°C		U34G		11,827,467
ProRS	Methanococcus jannaschii	Proline	null				0.18		65°C		U34A		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	null				0.75		65°C		U34A		11,827,467
ProRS	Methanococcus jannaschii	Proline	null				0.18		65°C		U34C		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	null				0.38		65°C		U34C		11,827,467
ProRS	Methanococcus jannaschii	Proline	null				0.13		65°C		G35A		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	null				0.07		65°C		G35A		11,827,467
ProRS	Methanococcus jannaschii	Proline	null				0.68		65°C		G35C		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	null				0.15		65°C		G35C		11,827,467
ProRS	Methanococcus jannaschii	Proline	null				0.03		65°C		G35U		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	null				0.08		65°C		G35U		11,827,467
ProRS	Methanococcus jannaschii	Proline	null				0.83		65°C		G36A		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	null				0.002		65°C		G36A		11,827,467
ProRS	Methanococcus jannaschii	Proline	null				0.01		65°C		G36C		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	null				1.38		65°C		G36C		11,827,467
ProRS	Methanococcus jannaschii	Proline	null				0.02		65°C		G36U		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	null				0.08		65°C		G36U		11,827,467
ProRS	Methanococcus jannaschii	Proline	null				0.008		65°C		G37A		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	null				0.07		65°C		G37A		11,827,467
ProRS	Methanococcus jannaschii	Proline	null				0.003		65°C		G35A, G37A		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	null				0.006		65°C		G35A, G37A		11,827,467
ProRS	Methanococcus jannaschii	Proline	null				0		65°C		G35A, G37C		11,827,467
ProRS	Methanococcus jannaschii	Cysteine	null				0.008		65°C		G35A, G37C		11,827,467
ProRS	Methanococcus jannaschii	Proline	null				0.001		65°C		G35A, G37U		11,827,467
CMP kinase	Escherichia coli	CMP	0.035	mM	103	s^-1	2940	s^-1mM^-1	30°C	7.4	Wild-type	ATP (1 mM)	11,827,479
CMP kinase	Escherichia coli	dCMP	0.094	mM	109	s^-1	1160	s^-1mM^-1	30°C	7.4	Wild-type	ATP (1 mM)	11,827,479
CMP kinase	Escherichia coli	AraCMP	0.53	mM	56	s^-1	105	s^-1mM^-1	30°C	7.4	Wild-type	ATP (1 mM)	11,827,479
CMP kinase	Escherichia coli	ddCMP	0.46	mM	0.047	s^-1	0.102	s^-1mM^-1	30°C	7.4	Wild-type	ATP (1 mM)	11,827,479
CMP kinase	Escherichia coli	CMP	0.47	mM	0.26	s^-1	0.54	s^-1mM^-1	30°C	7.4	D185A	ATP (1 mM)	11,827,479
CMP kinase	Escherichia coli	dCMP	0.24	mM	0.071	s^-1	0.30	s^-1mM^-1	30°C	7.4	D185A	ATP (1 mM)	11,827,479
CMP kinase	Escherichia coli	AraCMP	1	mM	0.085	s^-1	0.083	s^-1mM^-1	30°C	7.4	D185A	ATP (1 mM)	11,827,479
CMP kinase	Escherichia coli	ddCMP	0.15	mM	0.0083	s^-1	0.056	s^-1mM^-1	30°C	7.4	D185A	ATP (1 mM)	11,827,479
CMP kinase	Escherichia coli	CMP	0.19	mM	1.38	s^-1	7.4	s^-1mM^-1	30°C	7.4	R181M	ATP (1 mM)	11,827,479
CMP kinase	Escherichia coli	dCMP	0.24	mM	0.45	s^-1	1.9	s^-1mM^-1	30°C	7.4	R181M	ATP (1 mM)	11,827,479
CMP kinase	Escherichia coli	AraCMP	0.79	mM	1.36	s^-1	1.7	s^-1mM^-1	30°C	7.4	R181M	ATP (1 mM)	11,827,479
CMP kinase	Escherichia coli	ddCMP	0.54	mM	0.12	s^-1	0.22	s^-1mM^-1	30°C	7.4	R181M	ATP (1 mM)	11,827,479
CMP kinase	Escherichia coli	CMP	0.08	mM	56	s^-1	697	s^-1mM^-1	30°C	7.4	S101A	ATP (1 mM)	11,827,479
CMP kinase	Escherichia coli	dCMP	0.19	mM	1.2	s^-1	6.1	s^-1mM^-1	30°C	7.4	S101A	ATP (1 mM)	11,827,479
CMP kinase	Escherichia coli	AraCMP	0.47	mM	3.6	s^-1	7.5	s^-1mM^-1	30°C	7.4	S101A	ATP (1 mM)	11,827,479
BglB	Pyrococcus horikoshii	pNP-Glc	13.5	mM	34.4	s^-1	2.58	s^-1mM^-1	90°C	4.75	Wild-type		11,900,558
BglB	Pyrococcus horikoshii	pNP-Gal	7.3	mM	13.5	s^-1	1.9	s^-1mM^-1	90°C	4.75	Wild-type		11,900,558
BglB	Pyrococcus horikoshii	pNP-Man	0.44	mM	4.2	s^-1	9.8	s^-1mM^-1	90°C	4.75	Wild-type		11,900,558
BglB	Pyrococcus horikoshii	pNP-Glc	16.2	mM	25.5	s^-1	1.6	s^-1mM^-1	90°C	4.75	Q77R		11,900,558
BglB	Pyrococcus horikoshii	pNP-Gal	16.8	mM	14.2	s^-1	0.85	s^-1mM^-1	90°C	4.75	Q77R		11,900,558
BglB	Pyrococcus horikoshii	pNP-Man	1.1	mM	1.6	s^-1	1.4	s^-1mM^-1	90°C	4.75	Q77R		11,900,558
BglB	Pyrococcus horikoshii	pNP-Glc	0.3	mM	252	s^-1	870	s^-1mM^-1	90°C	4.75	D206N		11,900,558