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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If signs and symptoms suggestive of digoxin toxicity occur when enoxacin and digoxin are given concomitantly, physicians are advised to obtain serum digoxin levels and adjust digoxin doses appropriately. | <enoxacin, effect, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Non-steroidal anti-inflammatory agents: Seizures have been reported in patients taking enoxacin concomitantly with the nonsteroidal anti-inflammatory drug fenbufen. | <enoxacin, effect, fenbufen> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | or with multivitamins containing zinc may substantially interfere with drug absorption and result in insufficient plasma and tissue quinolone concentrations. | <zinc, mechanism, quinolone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antacids containing aluminum hydroxide and magnesium hydroxide reduce the oral absorption of enoxacin by 75%. | <aluminum hydroxide, mechanism, enoxacin>, <magnesium hydroxide, mechanism, enoxacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The oral bioavailability of enoxacin is reduced by 60% with coadministration of ranitidine. | <enoxacin, mechanism, ranitidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Theophylline: Enoxacin is a potent inhibitor of the cytochrome P-450 isozymes responsible for the metabolism of methylxanthines. | <Enoxacin, mechanism, methylxanthines> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Enoxacin interferes with the metabolism of theophylline resulting in a 42% to 74% dose-related decrease in theophylline clearance and a subsequent 260% to 350% increase in serum theophylline levels. | <Enoxacin, mechanism, theophylline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Theophylline-related adverse effects have occurred in patients when theophylline and enoxacin were coadministered. | <theophylline, effect, enoxacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Warfarin: Quinolones, including enoxacin, decrease the clearance of R-warfarin, the less active isomer of racemic warfarin. | <Quinolones, mechanism, R-warfarin>, <enoxacin, mechanism, R-warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nevertheless, the prothrombin time or other suitable coagulation test should be monitored when warfarin or its derivatives and enoxacin are given concomitantly. | <warfarin, advise, enoxacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Rifampin: Coadministration of rifampin and MEPRON Suspension results in a significant decrease in average steady- state plasma atovaquone concentrations. | <rifampin, mechanism, MEPRON> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Alternatives to rifampin should be considered during the course of PCP treatment with MEPRON. | <rifampin, advise, MEPRON> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Products containing calcium and other multivalent cations (such as aluminum, magnesium, iron) are likely to interfere with absorption of Ibandronate. | <calcium, mechanism, Ibandronate>, <aluminum, mechanism, Ibandronate>, <magnesium, mechanism, Ibandronate>, <iron, mechanism, Ibandronate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ibandronate should be taken at least 60 minutes before any oral medications containing multivalent cations (including antacids, supplements or vitamins). | <Ibandronate, advise, antacids>, <Ibandronate, advise, vitamins> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, since aspirin, NSAIDs, and bisphosphonates are all associated with gastrointestinal irritation, caution should be exercised in the concomitant use of aspirin or NSAIDs with Ibandronate. | <aspirin, advise, Ibandronate>, <NSAIDs, advise, Ibandronate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Total body clearance of Simulect was reduced by an average 22% and 51% when azathioprine and mycophenolate mofetil, respectively, were added to a regimen consisting of cyclosporine, USP (MODIFIED) and corticosteroids. | <Simulect, mechanism, azathioprine>, <Simulect, mechanism, mycophenolate mofetil> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The benzodiazepines, including alprazolam, produce additive CNS depressant effects when co-administered with other psychotropic medications, anticonvulsants, antihistaminics, ethanol, and other drugs which themselves produce CNS depression. | <benzodiazepines, effect, psychotropic medications>, <benzodiazepines, effect, anticonvulsants>, <benzodiazepines, effect, antihistaminics>, <benzodiazepines, effect, ethanol>, <alprazolam, effect, psychotropic medications>, <alprazolam, effect, anticonvulsants>, <alprazolam, effect, antihistaminics>, <alprazolam, effect, ethanol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The steady state plasma concentrations of imipramine and desipramine have been reported to be increased an average of 31% and 20%, respectively, by the concomitant administration of alprazolam tablets in doses up to 4 mg/day. | <imipramine, mechanism, alprazolam>, <desipramine, mechanism, alprazolam> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Drugs Demonstrated to be CYP 3A Inhibitors of Possible Clinical Significance on the Basis of Clinical Studies Involving Alprazolam (caution is recommended during coadministration with alprazolam): Coadministration of fluoxetine with alprazolam increased the maximum plasma concentration of alprazolam by 46%, decreased clearance by 21%, increased half-life by 17%, and decreased measured psychomotor performance. | <fluoxetine, mechanism, alprazolam> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coadministration of propoxyphene decreased the maximum plasma concentration of alprazolam by 6%, decreased clearance by 38%, and increased half-life by 58%. | <propoxyphene, mechanism, alprazolam> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coadministration of oral contraceptives increased the maximum plasma concentration of alprazolam by 18%, decreased clearance by 22%, and increased half-life by 29%. | <contraceptives, mechanism, alprazolam> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Drugs and other substances demonstrated to be CYP 3A inhibitors on the basis of clinical studies involving benzodiazepines metabolized similarly to alprazolam or on the basis of in vitro studies with alprazolam or other benzodiazepines (caution is recommended during coadministration with alprazolam): Available data from clinical studies of benzodiazepines other than alprazolam suggest a possible drug interaction with alprazolam for the following: diltiazem, isoniazid, macrolide antibiotics such as erythromycin and clarithromycin, and grapefruit juice. | <alprazolam, int, diltiazem>, <alprazolam, int, isoniazid>, <alprazolam, int, macrolide antibiotics>, <alprazolam, int, erythromycin>, <alprazolam, int, clarithromycin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Data from in vitro studies of alprazolam suggest a possible drug interaction with alprazolam for the following: sertraline and paroxetine. | <alprazolam, int, sertraline>, <alprazolam, int, paroxetine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Data from in vitro studies of benzodiazepines other than alprazolam suggest a possible drug interaction for the following: ergotamine, cyclosporine, amiodarone, nicardipine, and nifedipine. | <benzodiazepines, int, ergotamine>, <benzodiazepines, int, cyclosporine>, <benzodiazepines, int, amiodarone>, <benzodiazepines, int, nicardipine>, <benzodiazepines, int, nifedipine>, <alprazolam, int, ergotamine>, <alprazolam, int, cyclosporine>, <alprazolam, int, amiodarone>, <alprazolam, int, nicardipine>, <alprazolam, int, nifedipine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Interactions with Other CNS Agents: Concurrent use of Levo-Dromoran with all central nervous system depressants (eg, alcohol, sedatives, hypnotics, other opioids, general anesthetics, barbiturates, tricyclic antidepressants, phenothiazines, tranquilizers, skeletal muscle relaxants and antihistamines) may result in additive central nervous system depressant effects. | <Levo-Dromoran, effect, central nervous system depressants>, <Levo-Dromoran, effect, alcohol>, <Levo-Dromoran, effect, sedatives>, <Levo-Dromoran, effect, hypnotics>, <Levo-Dromoran, effect, opioids>, <Levo-Dromoran, effect, anesthetics>, <Levo-Dromoran, effect, barbiturates>, <Levo-Dromoran, effect, tricyclic antidepressants>, <Levo-Dromoran, effect, phenothiazines>, <Levo-Dromoran, effect, tranquilizers>, <Levo-Dromoran, effect, skeletal muscle relaxants>, <Levo-Dromoran, effect, antihistamines> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although no interaction between MAO inhibitors and Levo-Dromoran has been observed, it is not recommended for use with MAO inhibitors. | <Levo-Dromoran, advise, MAO inhibitors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Interactions with Mixed Agonist/Antagonist Opioid Analgesics: Agonist/antagonist analgesics (eg, pentazocine, nalbuphine, butorphanol, dezocine and buprenorphine) should NOT be administered to a patient who has received or is receiving a course of therapy with a pure agonist opioid analgesic such as Levo-Dromoran. | <Agonist/antagonist analgesics, advise, Levo-Dromoran>, <pentazocine, advise, Levo-Dromoran>, <nalbuphine, advise, Levo-Dromoran>, <butorphanol, advise, Levo-Dromoran>, <dezocine, advise, Levo-Dromoran>, <buprenorphine, advise, Levo-Dromoran>, <pure agonist opioid analgesic, advise, Levo-Dromoran> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Amitriptyline: Concurrent administration of 25 mg or 100 mg cinacalcet with 50 mg amitriptyline increased amitriptyline exposure and nortriptyline (active metabolite) exposure by approximately 20% in CYP2D6 extensive metabolizers. | <cinacalcet, mechanism, amitriptyline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Co-administration of ketoconazole, a strong inhibitor of CYP3A4, increased cinacalcet exposure following a single 90 mg dose of Sensipar by 2.3 fold. | <ketoconazole, mechanism, cinacalcet> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Dose adjustment of Sensipar may be required and PTH and serum calcium concentrations should be closely monitored if a patient initiates or discontinues therapy with a strong CYP3A4 inhibitor (e.g., ketoconazole, erythromycin, itraconazole; | <Sensipar, advise, ketoconazole>, <Sensipar, advise, erythromycin>, <Sensipar, advise, itraconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Co-treatment with the potent CYP3A4 inhibitor ketoconazole increases erlotinib AUC by 2/3. | <ketoconazole, mechanism, erlotinib> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Caution should be used when administering or taking TARCEVA with ketoconazole and other strong CYP3A4 inhibitors such as, but not limited to, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, troleandomycin (TAO), and voriconazole . | <TARCEVA, advise, ketoconazole>, <TARCEVA, advise, atazanavir>, <TARCEVA, advise, clarithromycin>, <TARCEVA, advise, indinavir>, <TARCEVA, advise, itraconazole>, <TARCEVA, advise, nefazodone>, <TARCEVA, advise, nelfinavir>, <TARCEVA, advise, ritonavir>, <TARCEVA, advise, saquinavir>, <TARCEVA, advise, telithromycin>, <TARCEVA, advise, troleandomycin>, <TARCEVA, advise, TAO>, <TARCEVA, advise, voriconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Pre-treatment with the CYP3A4 inducer rifampicin decreased erlotinib AUC by about 2/3. | <rifampicin, mechanism, erlotinib> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If the TARCEVA dose is adjusted upward, the dose will need to be reduced upon discontinuation of rifampicin or other inducers. | <TARCEVA, advise, rifampicin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Other depressasnts such as alcohol, barbiturates, and MAOIs may enhance CNS depression when administered with ethchlorvynol. | <alcohol, effect, ethchlorvynol>, <barbiturates, effect, ethchlorvynol>, <MAOIs, effect, ethchlorvynol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In the first study, concomitant administration of 0.2 mg cerivastatin sodium and 12 g cholestyramine resulted in decreases of more than 22% for AUC and 40% for Cmax when compared to dosing cerivastatin sodium alone. | <cerivastatin sodium, mechanism, cholestyramine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, in the second study, administration of 12 g cholestyramine 1 hour before the evening meal and 0.3 mg cerivastatin sodium approximately 4 hours after the same evening meal resulted in a decrease in the cerivastatin AUC of less than 8%, and a decrease in Cmax of about 30% when compared to dosing cerivastatin sodium alone. | <cholestyramine, mechanism, cerivastatin sodium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | ERYTHROMYCIN: In hypercholesterolemic patients, steady-state cerivastatin AUC and Cmax increased approximately 50% and 24% respectively after 10 days with co-administration of erythromycin, a known inhibitor of cytochrome P450 3A4. | <cerivastatin, mechanism, erythromycin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Allopurinol: The AUC of didanosine was increased about 4-fold when allopurinol at 300 mg/day was coadministered with a single 200-mg dose of VIDEX to two patients with renal impairment (CLcr=15 and 18 mL/min). | <allopurinol, mechanism, VIDEX> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antacids: Concomitant administration of antacids containing magnesium or aluminum with VIDEX Chewable/Dispersible Buffered Tablets or Pediatric Powder for Oral Solution may potentiate adverse events associated with the antacid components. | <antacids, effect, VIDEX>, <magnesium, effect, VIDEX>, <aluminum, effect, VIDEX> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Drugs Whose Absorption Can Be Affected by the Level of Acidity in the Stomach: Drugs such as ketoconazole and itraconazole should be administered at least 2 hours prior to dosing with VIDEX. | <ketoconazole, advise, VIDEX>, <itraconazole, advise, VIDEX> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ganciclovir: Administration of VIDEX 2 hours prior to or concurrent with oral ganciclovir was associated with a 111 (114)% increase in the steady-state AUC of didanosine (n = 12). | <VIDEX, mechanism, ganciclovir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | A 21 (17)% decrease in the steady-state AUC of ganciclovir was observed when VIDEX was administered 2 hours prior to ganciclovir, but not when the two drugs were administered simultaneously (n = 12). | <VIDEX, mechanism, ganciclovir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Quinolone Antibiotics: VIDEX should be administered at least 2 hours after or 6 hours before dosing with ciprofloxacin because plasma concentrations of ciprofloxacin are decreased when administered with antacids containing magnesium, calcium, or aluminum. | <VIDEX, advise, ciprofloxacin>, <ciprofloxacin, mechanism, magnesium>, <ciprofloxacin, mechanism, calcium>, <ciprofloxacin, mechanism, aluminum> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In eight HIV-infected patients, the steady-state AUC of ciprofloxacin was decreased an average of 26% (95% CI = 14%, 37%) when ciprofloxacin was administered 2 hours prior to a marketed chewable/dispersible tablet formulation of VIDEX. | <ciprofloxacin, mechanism, VIDEX> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The AUC of ciprofloxacin was decreased an average of 15-fold in 12 healthy subjects given ciprofloxacin and didanosine-placebo tablets concurrently. | <ciprofloxacin, mechanism, didanosine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In a single subject given one dose of ciprofloxacin 2 hours after a dose of didanosine-placebo tablets, a greater than 50% reduction in the AUC of ciprofloxacin was observed. | <ciprofloxacin, mechanism, didanosine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Plasma concentrations of quinolone antibiotics are decreased when administered with antacids containing magnesium, calcium, or aluminum. | <quinolone antibiotics, mechanism, magnesium>, <quinolone antibiotics, mechanism, calcium>, <quinolone antibiotics, mechanism, aluminum> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Interactions with Other Antiretroviral Drugs: Significant decreases in the AUC of delavirdine (20%) and indinavir (84%) occurred following simultaneous administration of these agents with VIDEX. | <delavirdine, mechanism, VIDEX>, <indinavir, mechanism, VIDEX> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | To avoid this interaction, delavirdine or indinavir should be given 1 hour prior to dosing with VIDEX. | <delavirdine, advise, VIDEX>, <indinavir, advise, VIDEX> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved. | <SSRI, effect, TCA> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nevertheless, caution is indicated in the coadministration of TCAs with any of the SSRIs and also in switching from one class to the other. | <TCAs, advise, SSRIs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Hyperpyrexia has been reported when amitriptyline HCl is administered with anticholinergic agents or with neuroleptic drugs, particularly during hot weather. | <amitriptyline HCl, effect, anticholinergic> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Paralytic ileus may occur in patients taking tricyclic antidepressants in combination with anticholinergic-type drugs. | <tricyclic antidepressants, effect, anticholinergic> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cimetidine is reported to reduce hepatic metabolism of certain tricyclic antidepressants, thereby delaying elimination and increasing steady-state concentrations of these drugs. | <Cimetidine, mechanism, tricyclic antidepressants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Clinically significant effects have been reported with the tricyclic antidepressants when used concomitantly with cimetidine. | <tricyclic antidepressants, effect, cimetidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Increases in plasma levels of tricyclic antidepressants, and in the frequency and severity of side effects, particularly anticholinergic, have been reported when cimetidine was added to the drug regimen. | <tricyclic antidepressants, mechanism, cimetidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Discontinuation of cimetidine in well-controlled patients receiving tricyclic antidepressants and cimetidine may decrease the plasma levels and efficacy of the antidepressants. | <tricyclic antidepressants, mechanism, cimetidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Transient delirium has been reported in patients who were treated with one gram of ethchlorvynol and 75 - 150 mg of amitriptyline HCl. | <ethchlorvynol, effect, amitriptyline HCl> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Pharmacologic studies indicate that there may be additive effects in prolonging AV conduction when using beta-blockers or digitalis concomitantly with Tiazac. | <beta-blockers, effect, Tiazac>, <digitalis, effect, Tiazac> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Administration of diltiazem hydrochloride concomitantly with propranolol in five normal volunteers resulted in increased propranolol levels in all subjects and bioavailability of propranolol was increased approximately 50%. | <diltiazem hydrochloride, mechanism, propranolol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In vitro, propranolol appears to be displaced from its binding sites by diltiazem. | <propranolol, mechanism, diltiazem> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | A study in six healthy volunteers has shown a significant increase in peak diltiazem plasma levels (58%) and AUC (53%) after a 1-week course of cimetidine 1200 mg/day and a single dose of diltiazem 60mg. | <cimetidine, mechanism, diltiazem> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The effect may be mediated by cimetidines known inhibition of hepatic cytochrome P-450, the enzyme system responsible for the first-pass metabolism of diltiazem. | <cimetidine, mechanism, diltiazem> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients currently receiving diltiazem therapy should be carefully monitored for a change in pharmacological effect when initiating and discontinuing therapy with cimetidine. | <diltiazem, advise, cimetidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Administration of diltiazem hydrochloride with digoxin in 24 healthy male subjects increased plasma digoxin concentrations approximately 20%. | <diltiazem hydrochloride, mechanism, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Since there have been conflicting results regarding the effect of digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing diltiazem hydrochloride therapy to avoid possible over- or under-digitalization. | <digoxin, advise, diltiazem hydrochloride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The depression of cardiac contractility, conductivity, and automaticity as well as the vascular dilation associated with anesthetics may be potentiated by calcium channel blockers. | <anesthetics, effect, calcium channel blockers> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When used concomitantly, anesthetics and calcium channel blockers should be titrated carefully. | <anesthetics, advise, calcium channel blockers> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | A pharmacokinetic interaction between diltiazem and cyclosporine has been observed during studies involving renal and cardiac transplant patients. | <diltiazem, int, cyclosporine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In renal and cardiac transplant recipients, a reduction of cyclosporine dose ranging from 15% to 48% was necessary to maintain cyclosporine trough concentrations similar to those seen prior to the addition of diltiazem. | <cyclosporine, mechanism, diltiazem> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If these agents are to be administered concurrently, cyclosporine concentrations should be monitored, especially when diltiazem therapy is initiated, adjusted, or discontinued. | <cyclosporine, advise, diltiazem> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concomitant administration of diltiazem with carbamazepine has been reported to result in elevated serum levels of carbamazepine (40% to 72% increase), resulting in toxicity in some cases. | <diltiazem, mechanism, carbamazepine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Studies showed that diltiazem increased the AUC of midazolam and triazolam by 3-4 fold and the Cmax by 2-fold, compared to placebo. | <diltiazem, mechanism, midazolam>, <diltiazem, mechanism, triazolam> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The elimination half life of midazolam and triazolam also increased (1.5-2.5 fold) during coadministration with diltiazem. | <midazolam, mechanism, diltiazem>, <triazolam, mechanism, diltiazem> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | These pharmacokinetic effects seen during diltiazem coadministration can result in increased clinical effects (e.g., prolonged sodation)of both midazolam and triazolam. | <diltiazem, effect, midazolam>, <diltiazem, effect, triazolam> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In a ten-subject study, coadministration of diltiazem (120 mg bid) with lovastatin resulted in a 3-4 times increase in mean lovastatin AUC and Cmax vs. lovastatin alone; | <diltiazem, mechanism, lovastatin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coadministration of rifampin with diltiazem lowered the diltiazem plasma concentrations to undetectable levels. | <rifampin, mechanism, diltiazem> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coadministration of diltiazem with rifampin or any known CYP3A4 inducer should be avoided when possible, and alternative therapy considered. | <diltiazem, advise, rifampin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Combinations of these drugs have not been studied and coadministration of CRIXIVAN and atazanavir is not recommended. | <CRIXIVAN, advise, atazanavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Dose reduction of CRIXIVAN to 600 mg every 8 hours should be considered when taking delavirdine 400 mg three times a day. | <CRIXIVAN, advise, delavirdine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Indinavir and didanosine formulations containing buffer should be administered at least one hour apart on an empty stomach. | <Indinavir, advise, didanosine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Increasing the indinavir dose to 1000 mg every 8 hours does not compensate for the increased indinavir metabolism due to efavirenz. | <indinavir, mechanism, efavirenz> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Indinavir concentrations may be decreased in the presence of nevirapine. | <Indinavir, mechanism, nevirapine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Preliminary clinical data suggest that the incidence of nephrolithiasis is higher in patients receiving indinavir in combination with ritonavir than those receiving CRIXIVAN 800 mg q8h. | <indinavir, effect, ritonavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Caution is warranted and therapeutic concentration monitoring is recommended for antiarrhythmics when coadministered with CRIXIVAN. | <antiarrhythmics, advise, CRIXIVAN> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | CRIXIVAN may not be effective due to decreased indinavir concentrations in patients taking these agents concomitantly. | <CRIXIVAN, effect, indinavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Use lowest possible dose of atorvastatin with careful monitoring, or consider HMG-CoA reductase inhibitors that are not primarily metabolized by CYP3A4, such as pravastatin, fluvastatin, or rosuvastatin in combination with CRIXIVAN. | <atorvastatin, advise, CRIXIVAN>, <HMG-CoA reductase inhibitors, advise, CRIXIVAN> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Dose reduction of CRIXIVAN to 600 mg every 8 hours is recommended when administering itraconazole concurrently. | <CRIXIVAN, advise, itraconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Dose reduction of rifabutin to half the standard dose and a dose increase of CRIXIVAN to 1000 mg (three 333-mg capsules) every 8 hours are recommended when rifabutin and CRIXIVAN are coadministered. | <rifabutin, advise, CRIXIVAN> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Sildenafil dose should not exceed a maximum of 25 mg in a 48- hour period in patients receiving concomitant indinavir therapy. | <Sildenafil, advise, indinavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Tadalafil dose should not exceed a maximum of 10 mg in a 72- hour period in patients receiving concomitant indinavir therapy. | <Tadalafil, advise, indinavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Vardenafil dose should not exceed a maximum of 2.5 mg in a 24-hour period in patients receiving concomitant indinavir therapy. | <Vardenafil, advise, indinavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Digoxin: Coadministration of digoxin, a P-glycoprotein substrate, with oral conivaptan resulted in a reduction in clearance and an increase in digoxin Cmax and AUC values. | <digoxin, mechanism, conivaptan> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, if digoxin is administered with VAPRISOL, the clinician should be alert to the possibility of increases in digoxin levels. | <digoxin, mechanism, VAPRISOL> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | There have been isolated reports of patients experiencing increases in their prothrombin times when etidronate was added to warfarin therapy. | <etidronate, effect, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Wait 5 weeks after stopping escitalopram before starting a non-selective MAO inhibitor. | <escitalopram, advise, non-selective MAO inhibitor> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Wait 2 weeks after stopping an MAO inhibitor before starting escitalopram. | <MAO inhibitor, advise, escitalopram> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Erythromycin use in patients who are receiving high doses of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity. | <Erythromycin, effect, theophylline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In case of theophylline toxicity and/or elevated serum theophylline levels, the dose of theophylline should be reduced while the patient is receiving concomitant erythromycin therapy. | <theophylline, advise, erythromycin> |