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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Orlistat-Orlistat may decrease the absorption of vitamin K. | <Orlistat, mechanism, vitamin K> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Warfarin-Vitamin K can antagonize the effect of warfarin | <Vitamin K, effect, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Anticoagulants: Flurbiprofen like other nonsteroidal anti-inflammatory drugs, has been shown to affect bleeding parameters in patients receiving anti-coagulants, and serious clinical bleeding has been reported. | <Flurbiprofen, effect, anti-coagulants>, <nonsteroidal anti-inflammatory drugs, effect, anti-coagulants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The physician should be cautious when administering flurbiprofen to patients taking anticoagulants. | <flurbiprofen, advise, anticoagulants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Aspirin: Concurrent administration of aspirin and flurbiprofen resulted in 50% lower serum flurbiprofen concentrations. | <aspirin, mechanism, flurbiprofen> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concurrent use of flurbiprofen and aspirin is therefore not recommended. | <flurbiprofen, advise, aspirin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Flurbiprofen pretreatment attenuated the hypotensive effect of a single dose of propranolol but not atenolol. | <Flurbiprofen, effect, propranolol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Flurbiprofen did not affect the pharmacokinetic profile of either drug, and the mechanism under lying the interference with propranolols hypotensive effect is unknown. | <Flurbiprofen, int, propranolol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients taking both flurbiprofen and a beta-blocker should be monitored to ensure that a satisfactory hypotensive effect is achieved. | <flurbiprofen, advise, beta-blocker> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cimetidine, Ranitidine: In normal volunteers (n=9), pretreatment with cimetidine or ranitidine did not affect flurbiprofen pharmacokinetics except that a small (13 %) but statistically significant increase in the area under the serum concentration curve of flurbiprofen resulted with cimetidine. | <flurbiprofen, mechanism, cimetidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Diuretics: Studies in normal volunteers have shown that flurbiprofen like other nonsteroidal anti-inflammatory drugs, can interfere with the effects of furosemide. | <flurbiprofen, effect, furosemide>, <nonsteroidal anti-inflammatory drugs, effect, furosemide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Other nonsteroidal anti-inflammatory drugs that inhibit prostaglandin synthesis have been shown to interfere with thiazide diuretics in some studies and with potassium-sparing diuretics. | <nonsteroidal anti-inflammatory drugs, effect, thiazide diuretics>, <nonsteroidal anti-inflammatory drugs, effect, potassium-sparing diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients receiving flurbiprofen and furosemide or other diuretics should be observed closely to determine if the desired effect is obtained. | <flurbiprofen, advise, furosemide>, <flurbiprofen, advise, diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although there was a slight reduction in blood sugar concentrations during concomitant administration of flurbiprofen and hypoglycemic agents, there were no signs or symptoms of hypoglycemia. | <flurbiprofen, effect, hypoglycemic agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | DISULFIRAM SHOULD BE USED WITH CAUTION IN THOSE PATIENTS REVEIVING PHENYTOIN AND ITS CONGENERS. | <DISULFIRAM, advise, PHENYTOIN> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | SINCE THE CONCOMITANT ADMINISTRATION OF THESE TWO DRUGS CAN LEAD TO PHENYTOIN INTOXICATION, PRIOR TO ADMINISTERING DISULFIRAM TO A PATIENT ON PHENYTOIN THERAPY, A BASELINE PHENYTOIN SERUM LEVEL SHOULD BE OBTAINED. | <DISULFIRAM, effect, PHENYTOIN> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It may be necessary to adjust the dosage of oral anticoagulants upon beginning or stopping disulfiram. since disulfiram may prolong prothrombin time. | <anticoagulants, advise, disulfiram> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients taking isoniazid when disulfiram is given should be observed for the appearance of unsteady gait or marked changes in mental status; | <isoniazid, advise, disulfiram> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In rats, simultaneous ingestion of disulfiram and nitrite in the diet for 78 weeks has been reported to cause tumors, and it has been suggested that disulfiram may react with nitrites in the rat stomach to form a nitrosamine, which is tumorigenic. | <disulfiram, effect, nitrite>, <disulfiram, effect, nitrites> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | A 30 to 45% increase in AUC and Cmax of nisoldipine was observed with concomitant administration of cimetidine 400 mg twice daily. | <nisoldipine, mechanism, cimetidine 400 mg> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coadministration of phenytoin with 40 mg SULAR tablets in epileptic patients lowered the nisoldipine plasma concentrations to undetectable levels. | <phenytoin, mechanism, SULAR> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coadministration of SULAR with phenytoin or any known CYP3A4 inducer should be avoided and alternative antihypertensive therapy should be considered. | <SULAR, advise, phenytoin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Propranolol attenuated the heart rate increase following administration of immediate release nisoldipine. | <Propranolol, effect, nisoldipine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The blood pressure effect of SULAR tended to be greater in patients on atenolol than in patients on no other antihypertensive therapy. | <SULAR, effect, atenolol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Quinidine at 648 mg bid decreased the bioavailability (AUC) of nisoldipine by 26%, but not the peak concentration. | <Quinidine, mechanism, nisoldipine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The immediate release, but not the coat-core formulation of nisoldipine increased plasma quinidine concentrations by about 20%. | <nisoldipine, mechanism, quinidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It is recommended that buspirone hydrochloride not be used concomitantly with MAO inhibitors Because the effects of concomitant administration of buspirone HCl with most other psychotropic drugs have not been studied, the concomitant use of buspirone HCl with other CNS-active drugs should be approached with caution. | <buspirone hydrochloride, advise, MAO inhibitors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | There is one report suggesting that the concomitant use of trazodone hydrochloride (Desyrel) and buspirone HCl may have caused 3- to 6-fold elevations on SGPT (ALT) in a few patients. | <trazodone hydrochloride, effect, buspirone HCl>, <Desyrel, effect, buspirone HCl> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In a study in normal volunteers, concomitant administration of buspirone HCl and haloperidol resulted in increased serum haloperidol concentrations. | <buspirone HCl, mechanism, haloperidol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, there has been one report of prolonged prothrombin time when buspirone was added to the regimen of a patient treated with warfarin. | <buspirone, effect, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In vitro, buspirone may displace less firmly bound drugs like digoxin. | <buspirone, mechanism, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concomitant use of L-phenylalanine and non-selective MAO inhibitors may cause hypertension. | <L-phenylalanine, effect, non-selective MAO inhibitors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Selegiline - L-phenylalanine and the selective MAO inhibitor selegiline may have synergistic antidepressant activity if used concomitantly. | <L-phenylalanine, effect, selegiline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Neuroleptic Drugs - L-phenylalanine may potentiate the tardive dyskinesia side reactions of neuroleptic drugs if used concomitantly with them. | <Neuroleptic Drugs, effect, L-phenylalanine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nabilone should be administered with caution to patients who are taking other psychoactive drugs or CNS depressants, including alcohol, barbiturates and narcotic analgesics, or to those with a history of psychiatric disorder (including manic-depressive illness and schizophrenia). | <Nabilone, advise, psychoactive drugs>, <Nabilone, advise, CNS depressants>, <Nabilone, advise, alcohol>, <Nabilone, advise, barbiturates>, <Nabilone, advise, narcotic analgesics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nabilone has been shown to have an additive CNS depressant effect when given with either diazepam, secobarbitone sodium, alcohol or codeine. | <Nabilone, effect, diazepam>, <Nabilone, effect, secobarbitone sodium>, <Nabilone, effect, alcohol>, <Nabilone, effect, codeine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Warfarin, Digoxin, Salicylate, and Heparin The in vitro binding of warfarin to plasma proteins is only slightly reduced by ketorolac tromethamine (99.5% control vs 99.3%) when ketorolac plasma concentrations reach 5 to10 m g/mL. | <warfarin, mechanism, ketorolac tromethamine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In vitro studies indicate that, at therapeutic concentrations of salicylate (300 m g/mL), the binding of ketorolac was reduced from approximately 99.2% to 97.5%, representing a potential twofold increase in unbound ketorolac plasma levels. | <salicylate, mechanism, ketorolac> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although these results do not indicate a significant interaction between TORADOL and warfarin or heparin, the administration of TORADOL to patients taking anticoagulants should be done extremely cautiously, and patients should be closely monitored. | <TORADOL, advise, anticoagulants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Furosemide: TORADOL IV/IM reduced the diuretic response to furosemide in normovolemic healthy subjects by approximately 20% (mean sodium and urinary output decreased 17%). | <TORADOL, effect, furosemide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Probenecid: Concomitant administration of TORADOL ORAL and probenecid resulted in decreased clearance of ketorolac and significant increases in ketorolac plasma levels (total AUC increased approximately threefold from 5.4 to 17.8 m g/h/mL) and terminal half-life increased approximately twofold from 6.6 to 15.1 hours. | <TORADOL, mechanism, probenecid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, concomitant use of TORADOL and probenecid is contraindicated. | <TORADOL, advise, probenecid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The effect of TORADOL on plasma lithium has not been studied, but cases of increased lithium plasma levels during TORADOL therapy have been reported. | <lithium, mechanism, TORADOL> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Methotrexate: Concomitant administration of methotrexate and some NSAIDs has been reported to reduce the clearance of methotrexate, enhancing the toxicity of methotrexate. | <methotrexate, mechanism, NSAIDs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antiepileptic Drugs: Sporadic cases of seizures have been reported during concomitant use of TORADOL and antiepileptic drugs (phenytoin, carbamazepine). | <TORADOL, effect, antiepileptic drugs>, <TORADOL, effect, phenytoin>, <TORADOL, effect, carbamazepine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Psychoactive Drugs: Hallucinations have been reported when TORADOL was used in patients taking psychoactive drugs (fluoxetine, thiothixene, alprazolam). | <TORADOL, effect, psychoactive drugs>, <TORADOL, effect, fluoxetine>, <TORADOL, effect, thiothixene>, <TORADOL, effect, alprazolam> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ethoxzolamide may increase the action of tricyclics, amphetamines, procainamide, and quinidine. | <Ethoxzolamide, effect, tricyclics>, <Ethoxzolamide, effect, amphetamines>, <Ethoxzolamide, effect, procainamide>, <Ethoxzolamide, effect, quinidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coadministration of ethoxzolamide with other diuretics, amphotericin B, and corticosteroids may cause hypokalemia. | <ethoxzolamide, effect, diuretics>, <ethoxzolamide, effect, amphotericin B>, <ethoxzolamide, effect, corticosteroids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Lithium Reversible increases in serum lithium concentrations and toxicity have been reported during concomitant administration of lithium with ACE inhibitors, and with some angiotensin II receptor antagonists. | <lithium, mechanism, ACE inhibitors>, <lithium, mechanism, angiotensin II receptor antagonists> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | An increase in serum lithium concentration has been reported during concomitant administration of lithium with ATACAND, so careful monitoring of serum lithium levels is recommended during concomitant use. | <lithium, mechanism, ATACAND> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Repeated doses of colestipol hydrochloride given prior to a single dose of propranolol in human trials have been reported to decrease propranolol absorption. | <colestipol hydrochloride, mechanism, propranolol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, patients on propranolol should be observed when COLESTID Tablets are either added or deleted from a therapeutic regimen. | <propranolol, advise, COLESTID> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Studies in humans show that the absorption of chlorothiazide as reflected in urinary excretion is markedly decreased even when administered one hour before colestipol hydrochloride. | <chlorothiazide, mechanism, colestipol hydrochloride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; | <tetracycline, mechanism, colestipol hydrochloride>, <furosemide, mechanism, colestipol hydrochloride>, <penicillin G, mechanism, colestipol hydrochloride>, <hydrochlorothiazide, mechanism, colestipol hydrochloride>, <gemfibrozil, mechanism, colestipol hydrochloride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Particular caution should be observed with digitalis preparations since there are conflicting results for the effect of colestipol hydrochloride on the availability of digoxin and digitoxin. | <digitalis preparations, effect, colestipol hydrochloride>, <colestipol hydrochloride, mechanism, digoxin>, <colestipol hydrochloride, mechanism, digitoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Bile acid binding resins may also interfere with the absorption of oral phosphate supplements and hydrocortisone. | <Bile acid binding resins, mechanism, phosphate>, <Bile acid binding resins, mechanism, hydrocortisone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Benzthiazide may interact with alcohol, blood thinners, decongestant drugs (allergy, cold, and sinus medicines), diabetic drugs, lithium, norepinephrine, NSAIDs like Aleve or Ibuprofen, and high blood pressure medications. | <Benzthiazide, int, alcohol>, <Benzthiazide, int, blood thinner>, <Benzthiazide, int, decongestant drugs>, <Benzthiazide, int, lithium>, <Benzthiazide, int, norepinephrine>, <Benzthiazide, int, NSAIDs>, <Benzthiazide, int, Aleve>, <Benzthiazide, int, Ibuprofen> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The risk of using bromocriptine mesylate in combination with other drugs has not been systematically evaluated, but alcohol may potentiate the side effects of bromocriptine mesylate. | <alcohol, effect, bromocriptine mesylate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Bromocriptine mesylate may interact with dopamine antagonists, butyrophenones, and certain other agents. | <Bromocriptine mesylate, int, dopamine antagonists>, <Bromocriptine mesylate, int, butyrophenones> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Compounds in these categories result in a decreased efficacy of bromocriptine mesylate: phenothiazines, haloperidol, metoclopramide, pimozide. | <bromocriptine mesylate, effect, phenothiazines>, <bromocriptine mesylate, effect, haloperidol>, <bromocriptine mesylate, effect, metoclopramide>, <bromocriptine mesylate, effect, pimozide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concomitant use of bromocriptine mesylate with other ergot alkaloids is not recommended. | <bromocriptine mesylate, advise, ergot alkaloids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, linezolid has the potential for interaction with adrenergic and serotonergic agents. | <linezolid, int, adrenergic>, <linezolid, int, serotonergic agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Adrenergic Agents:Some individuals receiving ZYVOX may experience a reversible enhancement of the pressor response to indirect-acting sympathomimetic agents, vasopressor or dopaminergic agents. | <ZYVOX, effect, sympathomimetic agents>, <ZYVOX, effect, vasopressor>, <ZYVOX, effect, dopaminergic agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Spontaneous reports of serotonin syndrome associated with co-administration of ZYVOX and serotonergic agents, including antidepressants such as selective serotonin reuptake inhibitors (SSRIs), have been reported. | <ZYVOX, effect, serotonergic agents>, <ZYVOX, effect, antidepressants>, <ZYVOX, effect, selective serotonin reuptake inhibitors>, <ZYVOX, effect, SSRIs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients who are treated with ZYVOX and concomitant serotonergic agents should be closely observed for signs and symptoms of serotonin syndrome (e.g., cognitive dysfunction, hyperpyrexia, hyperreflexia, incoordination). | <ZYVOX, effect, serotonergic agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If any signs or symptoms occur physicians should consider discontinuation of either one or both agents (ZYVOX or concomitant serotonergic agents). | <ZYVOX, advise, serotonergic agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coumarin Anticoagulants Altered coagulation parameters and/or bleeding have been reported in patients taking capecitabine concomitantly with coumarin-derivative anticoagulants such as warfarin and phenprocoumon. | <capecitabine, effect, coumarin-derivative anticoagulants>, <capecitabine, effect, phenprocoumon> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients taking coumarin-derivative anticoagulants concomitantly with capecitabine should be monitored regularly for alterations in their coagulation parameters (PT or INR). | <coumarin-derivative anticoagulants, advise, capecitabine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Leucovorin: The concentration of 5-fluorouracil is increased and its toxicity may be enhanced by leucovorin. | <5-fluorouracil, mechanism, leucovorin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Deaths from severe enterocolitis, diarrhea, and dehydration have been reported in elderly patients receiving weekly leucovorin and fluorouracil. | <leucovorin, effect, fluorouracil> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The rate of metabolism and the leukopenic activity of cyclophosphamide reportedly are increased by chronic administration of high doses of phenobarbital. | <cyclophosphamide, mechanism, phenobarbital> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cyclophosphamide treatment, which causes a marked and persistent inhibition of cholinesterase activity, potentiates the effect of succinylcholine chloride. | <Cyclophosphamide, effect, succinylcholine chloride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Iodine or iodine excess may decrease the effect of Carbimazole, and an iodine deficiency can increase the effect of Carbimazole. | <Iodine, effect, Carbimazole>, <iodine, effect, Carbimazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Serum concentration of digoxin and digitoxin may increase when patients take antithyroid agents. | <digoxin, mechanism, antithyroid agents>, <digitoxin, mechanism, antithyroid agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antithyroid agents may decrease thyroidal uptake of sodium iodide I131, a rebound in uptake may occur up to 5 days after sudden withdrawal of Carbimazole. | <Antithyroid agents, effect, sodium iodide I131> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Based on anecdotal reports, there may be an interaction between buprenorphine and benzodiazepines. | <buprenorphine, int, benzodiazepines> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | There have been a number of reports in the post-marketing experience of coma and death associated with the concomitant intravenous misuse of buprenorphine and benzodiazepines by addicts. | <buprenorphine, effect, benzodiazepines> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | SUBUTEX and SUBOXONE should be prescribed with caution to patients on benzodiazepines or other drugs that act on the central nervous system, regardless of whether these drugs are taken on the advice of a physician or are taken as drugs of abuse. | <SUBUTEX, advise, benzodiazepines>, <SUBOXONE, advise, benzodiazepines> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients should be warned of the potential danger of the intravenous self-administration of benzodiazepines while under treatment with SUBOXONE or SUBUTEX. | <benzodiazepines, advise, SUBOXONE>, <benzodiazepines, advise, SUBUTEX> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Blood levels of hydrodolasetron increased 24% when dolasetron was coadministered with cimetidine (nonselective inhibitor of cytochrome P-450) for 7 days, and decreased 28% with coadministration of rifampin (potent inducer of cytochrome P-450) for 7 days. | <dolasetron, mechanism, cimetidine>, <dolasetron, mechanism, rifampin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Clearance of hydrodolasetron decreased by about 27% when dolasetron mesylate was administered intravenously concomitantly with atenolol. | <dolasetron mesylate, mechanism, atenolol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Chlorprothixene may increase the plasma-level of concomitantly given lithium. | <Chlorprothixene, mechanism, lithium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If chlorprothixene is given concomitantly with opioids, the opioid dose should be reduced (by approx. 50%), because chlorprothixene amplifies the therapeutic actions and side-effects of opioids massively. | <chlorprothixene, advise, opioids>, <chlorprothixene, effect, opioids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Avoid the concomitant use of chlorprothixene and tramadol (Ultram). | <chlorprothixene, advise, tramadol>, <chlorprothixene, advise, Ultram> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Consider additive sedative effects and confusional states to emerge, if chlorprothixene is given with benzodiazepines or barbituates. | <chlorprothixene, effect, benzodiazepines>, <chlorprothixene, effect, barbituates> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Exert particular caution in combining chlorprothixene with other anticholinergic drugs (tricyclic antidepressants and antiparkinsonian agents): Particularly the elderly may develop delirium, high fever, severe obstipation, even ileus and glaucoma. | <chlorprothixene, advise, anticholinergic drugs>, <chlorprothixene, advise, tricyclic antidepressants>, <chlorprothixene, advise, antiparkinsonian agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Use in Conjunction with Other Antiepileptic Drugs: The addition of Felbatol to antiepileptic drugs (AEDs) affects the steady-state plasma concentrations of AEDs. | <Felbatol, mechanism, antiepileptic drugs>, <Felbatol, mechanism, AEDs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Specific Effects of Felbatol on Other Antiepileptic Drugs Phenytoin: Felbatol causes an increase in steady-state phenytoin plasma concentrations. | <Felbatol, mechanism, phenytoin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Increasing the felbamate dose to 1800 mg/day in six of these subjects increased the steady-state phenytoin Cmin to 25 7 micrograms/mL. | <felbamate, mechanism, phenytoin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In order to maintain phenytoin levels, limit adverse experiences, and achieve the felbamate dose of 3600 mg/day, a phenytoin dose reduction of approximately 40% was necessary for eight of these 10 subjects. | <felbamate, advise, phenytoin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Carbamazepine: Felbatol causes a decrease in the steady-state carbamazepine plasma concentrations and an increase in the steady-state carbamazepine epoxide plasma concentration. | <Felbatol, mechanism, carbamazepine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The carbamazepine steady-state Cmin decreased 31% to 5 1 micrograms/mL when felbamate (3000 mg/day, divided into three doses) was coadministered. | <carbamazepine, mechanism, felbamate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Valproate: Felbatol causes an increase in steady-state valproate concentrations. | <Felbatol, mechanism, valproate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Increasing the felbamate dose to 2400 mg/day increased the steadystate valproate Cmin to 96 25 micrograms/mL. | <felbamate, mechanism, valproate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Phenobarbital: Coadministration of felbamate with phenobarbital causes an increase in phenobarbital plasma concentrations, In 12 otherwise healthy male volunteers ingesting phenobarbital, the steady-state trough (Cmin) phenobarbital concentration was 14.2 micrograms/mL. | <felbamate, mechanism, phenobarbital> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Effects of Other Antiepileptic Drugs on Felbatol Phenytoin: Phenytoin causes an approximate doubling of the clearance of Felbatol (felbamate) at steady state and, therefore, the addition of phenytoin causes an approximate 45% decrease in the steady-state trough concentrations of Felbatol as compared to the same dose of Felbatol given as monotherapy. | <Phenytoin, mechanism, Felbatol>, <Phenytoin, mechanism, felbamate>, <phenytoin, mechanism, Felbatol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Carbamazepine: Carbamazepine causes an approximate 50% increase in the clearance of Felbatol at steady state and, therefore, the addition of carbamazepine results in an approximate 40% decrease in the steady-state trough concentrations of Felbatol as compared to the same dose of Felbatol given as monotherapy. | <Carbamazepine, mechanism, Felbatol>, <carbamazepine, mechanism, Felbatol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Phenobarbital: It appears that phenobarbital may reduce plasma felbamate concentrations. | <phenobarbital, mechanism, felbamate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Felbamate treatment resulted in a 42% decrease in the gestodene AUC 0-24, but no clinically relevant effect was observed on the pharmacokinetic parameters of ethinyl estradiol. | <Felbamate, mechanism, gestodene> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Chirocaine should be used with caution in patients receiving other local anesthetics or agents structurally related to amide-type local anesthetics since the toxic effects of these drugs could be additive. | <Chirocaine, advise, anesthetics> |