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http://www.ncbi.nlm.nih.gov/pubmed/17767915,http://www.ncbi.nlm.nih.gov/pubmed/10220385,http://www.ncbi.nlm.nih.gov/pubmed/23724067,http://www.ncbi.nlm.nih.gov/pubmed/26927903,http://www.ncbi.nlm.nih.gov/pubmed/27345839,http://www.ncbi.nlm.nih.gov/pubmed/10869435,http://www.ncbi.nlm.nih.gov/pubmed/11602581,http://www.ncbi.nlm.nih.gov/pubmed/28930559,http://www.ncbi.nlm.nih.gov/pubmed/17227860,http://www.ncbi.nlm.nih.gov/pubmed/27668865,http://www.ncbi.nlm.nih.gov/pubmed/15050820,http://www.ncbi.nlm.nih.gov/pubmed/23088873,http://www.ncbi.nlm.nih.gov/pubmed/22621256,http://www.ncbi.nlm.nih.gov/pubmed/19443688,http://www.ncbi.nlm.nih.gov/pubmed/27939885,http://www.ncbi.nlm.nih.gov/pubmed/28078999 | What is the function of HDAC proteins? | Histone deacetylases influence diverse cellular processes and may contribute to tumor development and progression by multiple mechanisms. Histone deacetylases prevent the relaxation of chromatin, and positively or negatively regulate transcription. Histone deacetylases (HDACs) prevent the relaxation of chromatin, and positively or negatively regulate transcription and thus cellular processes |
http://www.ncbi.nlm.nih.gov/pubmed/24737863,http://www.ncbi.nlm.nih.gov/pubmed/26275423,http://www.ncbi.nlm.nih.gov/pubmed/25491770 | What is the H4S47C cleavage mapping method used for? | To identify nucleosomes with alternative structures genome-wide, we used H4S47C-anchored cleavage mapping, which revealed that 5% of budding yeast (Saccharomyces cerevisiae) nucleosome positions have asymmetric histone-DNA interactions. To map fission yeast centromeres, we applied H4S47C-anchored cleavage mapping and native and cross-linked chromatin immunoprecipitation with paired-end sequencing. To resolve this controversy, we have applied H4S47C-anchored cleavage mapping, which reveals the precise position of histone H4 in every nucleosome in the genome.H4S47C-anchored cleavage mapping reveals the precise position of histone H4 in every nucleosome in the genome. To map fission yeast centromeres, we applied H4S47C-anchored cleavage mapping and native and cross-linked chromatin immunoprecipitation with paired-end sequencing. To resolve this controversy, we have applied H4S47C-anchored cleavage mapping, which reveals the precise position of histone H4 in every nucleosome in the genome.To map fission yeast centromeres, we applied H4S47C-anchored cleavage mapping and native and cross-linked chromatin immunoprecipitation with paired-end sequencing. To identify nucleosomes with alternative structures genome-wide, we used H4S47C-anchored cleavage mapping, which revealed that 5% of budding yeast (Saccharomyces cerevisiae) nucleosome positions have asymmetric histone-DNA interactions.To map fission yeast centromeres, we applied H4S47C-anchored cleavage mapping and native and cross-linked chromatin immunoprecipitation with paired-end sequencing. |
http://www.ncbi.nlm.nih.gov/pubmed/27264557,http://www.ncbi.nlm.nih.gov/pubmed/28668117 | Which human gene encode for DNA polymerase θ? | DNA polymerase theta (pol θ) is an evolutionarily conserved protein encoded by the POLQ gene in mammalian genomes |
http://www.ncbi.nlm.nih.gov/pubmed/24942628 | In what percentage of skeletal muscle fibers is dystrophin expression restored after PPMO- mediated exon skipping? | PPMO-mediated exon skipping restored the dystrophin expression in nearly 100% skeletal muscle fibers in all age groups. |
http://www.ncbi.nlm.nih.gov/pubmed/28253710 | Which miRNA is associated with the circular RNA ciRS-7? | circular RNA-7 (ciRS-7) acts as a sponge of miR-7 and thus inhibits its activity. |
http://www.ncbi.nlm.nih.gov/pubmed/28293225,http://www.ncbi.nlm.nih.gov/pubmed/27900395 | Which are the two main bacterial phyla in human gut? | Out of thousands of bacterial species-level phylotypes inhabiting the human gut, the majority belong to two dominant phyla, the Bacteroidetes and Firmicutes |
http://www.ncbi.nlm.nih.gov/pubmed/20439976,http://www.ncbi.nlm.nih.gov/pubmed/24056028,http://www.ncbi.nlm.nih.gov/pubmed/28810279,http://www.ncbi.nlm.nih.gov/pubmed/25412185 | What are 7 symptoms of yellow fever? | Yellow fever is considered to be a hemorrhagic fever and illness is characterized by fever, headache, myalgia, gastrointestinal symptoms, hepatic and renal dysfunction, multi-organ failure, shock and coagulopathy. |
http://www.ncbi.nlm.nih.gov/pubmed/23267377,http://www.ncbi.nlm.nih.gov/pubmed/2378506,http://www.ncbi.nlm.nih.gov/pubmed/7819984,http://www.ncbi.nlm.nih.gov/pubmed/6600702,http://www.ncbi.nlm.nih.gov/pubmed/21137654 | Which test is used for the definition of colour-blindness? | Color-blindness problems are detected by the Ishihara Test.12 patients had color blindness based on the Ishihara test12 patients had color blindness based on the Ishihara test. |
http://www.ncbi.nlm.nih.gov/pubmed/29055574,http://www.ncbi.nlm.nih.gov/pubmed/25792283,http://www.ncbi.nlm.nih.gov/pubmed/26877254,http://www.ncbi.nlm.nih.gov/pubmed/28358602 | Of what origin is the MCF-7 cell line? | MCF7 is an ER+ breast cancer cell line. |
http://www.ncbi.nlm.nih.gov/pubmed/17050378,http://www.ncbi.nlm.nih.gov/pubmed/22814255,http://www.ncbi.nlm.nih.gov/pubmed/27126993,http://www.ncbi.nlm.nih.gov/pubmed/22266188,http://www.ncbi.nlm.nih.gov/pubmed/26351669 | Is lumican a secreted protein? | Yes, Lumican is a secreted proteoglycan that regulates collagen fibril assembly. |
http://www.ncbi.nlm.nih.gov/pubmed/16432264,http://www.ncbi.nlm.nih.gov/pubmed/20834094 | Cytochrome p450 CYP3A is induced by rifampicin and compounds used to treat what virus? | Etravirine is an effective and well-tolerated recently approved non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV type-1-infected patients with previous antiretroviral treatment experience. Etravirine is a weak inducer of cytochrome P450 (CYP)3AFour CYP3A inducers were used: rifampicin, rifabutin, carbamazepine, and efavirenz Etravirine is an effective and well-tolerated recently approved non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV type-1-infected patients with previous antiretroviral treatment experience. |
http://www.ncbi.nlm.nih.gov/pubmed/15815621,http://www.ncbi.nlm.nih.gov/pubmed/27423248,http://www.ncbi.nlm.nih.gov/pubmed/22419167,http://www.ncbi.nlm.nih.gov/pubmed/28333343,http://www.ncbi.nlm.nih.gov/pubmed/11435402,http://www.ncbi.nlm.nih.gov/pubmed/1924367,http://www.ncbi.nlm.nih.gov/pubmed/11196135 | Which human chromosome is the product of fusion? | The evolution of African great ape subtelomeric heterochromatin and the fusion of human chromosome 2. We propose a model where an ancestral human-chimpanzee pericentric inversion and the ancestral chromosome 2 fusion both predisposed and protected the chimpanzee and human genomes, respectively, to the formation of subtelomeric heterochromatin. The evolution of African great ape subtelomeric heterochromatin and the fusion of human chromosome 2.Origin of human chromosome 2: an ancestral telomere-telomere fusion.Human chromosome 2 originated from the fusion of two ancestral primate chromosomes.Origin of human chromosome 2: an ancestral telomere-telomere fusion. It is known that human chromosome 2 originated from the fusion of two ancestral primate chromosomes. The evolution of African great ape subtelomeric heterochromatin and the fusion of human chromosome 2. |
http://www.ncbi.nlm.nih.gov/pubmed/23486470,http://www.ncbi.nlm.nih.gov/pubmed/25477371,http://www.ncbi.nlm.nih.gov/pubmed/26268754,http://www.ncbi.nlm.nih.gov/pubmed/28327103,http://www.ncbi.nlm.nih.gov/pubmed/26493939,http://www.ncbi.nlm.nih.gov/pubmed/25960617 | Where is the EpCam protein mainly located? | Epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein |
http://www.ncbi.nlm.nih.gov/pubmed/27653758,http://www.ncbi.nlm.nih.gov/pubmed/26095540,http://www.ncbi.nlm.nih.gov/pubmed/24624626,http://www.ncbi.nlm.nih.gov/pubmed/26369819,http://www.ncbi.nlm.nih.gov/pubmed/25322783,http://www.ncbi.nlm.nih.gov/pubmed/28439702,http://www.ncbi.nlm.nih.gov/pubmed/23649961,http://www.ncbi.nlm.nih.gov/pubmed/23677804,http://www.ncbi.nlm.nih.gov/pubmed/24711240,http://www.ncbi.nlm.nih.gov/pubmed/23535530,http://www.ncbi.nlm.nih.gov/pubmed/21985171 | What is the drug target for Eliquis (Apixaban)? | The new oral anticoagulants (NOAC) Apixaban (Eliquis) is a direct anti-Xa inhibitors |
http://www.ncbi.nlm.nih.gov/pubmed/26572762,http://www.ncbi.nlm.nih.gov/pubmed/27334944 | What in vivo tau tracers are being used? | in-vivo tau PET imaging ligands include [(18)F]THK523, [(18)F]THK5117, [(18)F]THK5105 and [(18)F]THK5351, [(18)F]AV1451(T807) [(11)C]PBB3, (18)F-THK5117, [(18)F]T808, 18F-RO6958948. |
http://www.ncbi.nlm.nih.gov/pubmed/20832171,http://www.ncbi.nlm.nih.gov/pubmed/28114822,http://www.ncbi.nlm.nih.gov/pubmed/1688935,http://www.ncbi.nlm.nih.gov/pubmed/22453493,http://www.ncbi.nlm.nih.gov/pubmed/3347367,http://www.ncbi.nlm.nih.gov/pubmed/23308208,http://www.ncbi.nlm.nih.gov/pubmed/8731171,http://www.ncbi.nlm.nih.gov/pubmed/8628579,http://www.ncbi.nlm.nih.gov/pubmed/23583574,http://www.ncbi.nlm.nih.gov/pubmed/1484716,http://www.ncbi.nlm.nih.gov/pubmed/24847424,http://www.ncbi.nlm.nih.gov/pubmed/6493793,http://www.ncbi.nlm.nih.gov/pubmed/27987222,http://www.ncbi.nlm.nih.gov/pubmed/19168051,http://www.ncbi.nlm.nih.gov/pubmed/27284395,http://www.ncbi.nlm.nih.gov/pubmed/27716994,http://www.ncbi.nlm.nih.gov/pubmed/22891086,http://www.ncbi.nlm.nih.gov/pubmed/25436084,http://www.ncbi.nlm.nih.gov/pubmed/9431444,http://www.ncbi.nlm.nih.gov/pubmed/28073097,http://www.ncbi.nlm.nih.gov/pubmed/15172765 | What is the Formalin test used for? | And persistent pain produced by peripheral tissue injury and inflammation was modeled by formalin test. And persistent pain produced by peripheral tissue injury and inflammation was modeled by formalin test.Persistent pain, In vivo antinociceptive activity, is produced by peripheral tissue injury and inflammation and is modeled by formalin test. |
http://www.ncbi.nlm.nih.gov/pubmed/28255506,http://www.ncbi.nlm.nih.gov/pubmed/12520314,http://www.ncbi.nlm.nih.gov/pubmed/26074484,http://www.ncbi.nlm.nih.gov/pubmed/2797370,http://www.ncbi.nlm.nih.gov/pubmed/15043358,http://www.ncbi.nlm.nih.gov/pubmed/27923756,http://www.ncbi.nlm.nih.gov/pubmed/23351908,http://www.ncbi.nlm.nih.gov/pubmed/27347652 | What drug treatment can cause a spinal epidural hematoma? | Spinal epidural hematoma (SEH) is a rare disease that causes cord compression and neurologic deficit. Spontaneous SEH is related to minor trauma, bleeding disorders, and anticoagulant medications.Spinal epidural hematomas are rare entity in neurosurgery practice. Most of them are spontaneous due to anticoagulant therapy and called spontaneous spinal epidural hematomas (SSEHs).Spinal epidural hematoma (SEH) is a rare disease that causes cord compression and neurologic deficit.pinal subdural hematoma associated with antiplatelet therapy |
http://www.ncbi.nlm.nih.gov/pubmed/9735324,http://www.ncbi.nlm.nih.gov/pubmed/22905336,http://www.ncbi.nlm.nih.gov/pubmed/10381356,http://www.ncbi.nlm.nih.gov/pubmed/10434299 | List diseases caused by protein glutamine expanded repeats | Huntington's Disease,
dentatorubral-pallidoluysian atrophy |
http://www.ncbi.nlm.nih.gov/pubmed/23124521 | What is the nucleotide composition of the Lamin Associated Domains (LADs)? | Instead, cLADs are universally characterized by long stretches of DNA of high A/T content. This suggests that the A/T rule represents a default positioning mechanism that is locally overruled during lineage commitment.Cell-type specific LADs also tend to adhere to this "A/T rule" in embryonic stem cells, but not in differentiated cells. Instead, cLADs are universally characterized by long stretches of DNA of high A/T content. Analysis of paralogs suggests that during evolution changes in A/T content have driven the relocation of genes to and from the nuclear lamina, in tight association with changes in expression level Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence.Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence. Analysis of paralogs suggests that during evolution changes in A/T content have driven the relocation of genes to and from the nuclear lamina, in tight association with changes in expression levelInstead, cLADs are universally characterized by long stretches of DNA of high A/T content. Cell-type specific LADs also tend to adhere to this "A/T rule" in embryonic stem cells, but not in differentiated cells.Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence.Instead, cLADs are universally characterized by long stretches of DNA of high A/T content. Analysis of paralogs suggests that during evolution changes in A/T content have driven the relocation of genes to and from the nuclear lamina, in tight association with changes in expression levelInstead, cLADs are universally characterized by long stretches of DNA of high A/T content. Analysis of paralogs suggests that during evolution changes in A/T content have driven the relocation of genes to and from the nuclear lamina, in tight association with changes in expression level. This suggests that the A/T rule represents a default positioning mechanism that is locally overruled during lineage commitment. Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence. Cell-type specific LADs also tend to adhere to this "A/T rule" in embryonic stem cells, but not in differentiated cells. Instead, cLADs are universally characterized by long stretches of DNA of high A/T content. In metazoans, the nuclear lamina is thought to play an important role in the spatial organization of interphase chromosomes, by providing anchoring sites for large genomic segments named lamina-associated domains (LADs). Some of these LADs are cell-type specific, while many others appear constitutively associated with the lamina. Constitutive LADs (cLADs) may contribute to a basal chromosome architecture. cLADs are universally characterized by long stretches of DNA of high A/T content. Cell-type specific LADs also tend to adhere to this "A/T rule" in embryonic stem cells, but not in differentiated cells. This suggests that the A/T rule represents a default positioning mechanism that is locally overruled during lineage commitment. Analysis of paralogs suggests that during evolution changes in A/T content have driven the relocation of genes to and from the nuclear lamina, in tight association with changes in expression level.Instead, cLADs are universally characterized by long stretches of DNA of high A/T content. Cell-type specific LADs also tend to adhere to this "A/T rule" in embryonic stem cells, but not in differentiated cells. This suggests that the A/T rule represents a default positioning mechanism that is locally overruled during lineage commitment. Analysis of paralogs suggests that during evolution changes in A/T content have driven the relocation of genes to and from the nuclear lamina, in tight association with changes in expression levelAnalysis of paralogs suggests that during evolution changes in A/T content have driven the relocation of genes to and from the nuclear lamina, in tight association with changes in expression level. Instead, cLADs are universally characterized by long stretches of DNA of high A/T content. Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence. This suggests that the A/T rule represents a default positioning mechanism that is locally overruled during lineage commitment. Cell-type specific LADs also tend to adhere to this "A/T rule" in embryonic stem cells, but not in differentiated cells. |
http://www.ncbi.nlm.nih.gov/pubmed/18502808,http://www.ncbi.nlm.nih.gov/pubmed/16669634,http://www.ncbi.nlm.nih.gov/pubmed/22704991 | What is the clathrin triskelia structure? | The clathrin triskelion, which is a three-legged pinwheel-shaped heteropolymer, is a major component in the protein coats of certain post-Golgi and endocytic vesicles. |
http://www.ncbi.nlm.nih.gov/pubmed/21343408,http://www.ncbi.nlm.nih.gov/pubmed/27638763,http://www.ncbi.nlm.nih.gov/pubmed/25682762,http://www.ncbi.nlm.nih.gov/pubmed/21720767,http://www.ncbi.nlm.nih.gov/pubmed/27829268,http://www.ncbi.nlm.nih.gov/pubmed/27235538,http://www.ncbi.nlm.nih.gov/pubmed/28925106,http://www.ncbi.nlm.nih.gov/pubmed/29054040,http://www.ncbi.nlm.nih.gov/pubmed/23780694 | What is myelin? | Myelin is a specialized structure of the nervous system that covers the neuron and both enhances electrical conductance and insulates neurons from external risk factors. |
http://www.ncbi.nlm.nih.gov/pubmed/18390151,http://www.ncbi.nlm.nih.gov/pubmed/24480149,http://www.ncbi.nlm.nih.gov/pubmed/18387752,http://www.ncbi.nlm.nih.gov/pubmed/22826490,http://www.ncbi.nlm.nih.gov/pubmed/17296251,http://www.ncbi.nlm.nih.gov/pubmed/22194770,http://www.ncbi.nlm.nih.gov/pubmed/24609497,http://www.ncbi.nlm.nih.gov/pubmed/16739129,http://www.ncbi.nlm.nih.gov/pubmed/24762925,http://www.ncbi.nlm.nih.gov/pubmed/20140321,http://www.ncbi.nlm.nih.gov/pubmed/16368972,http://www.ncbi.nlm.nih.gov/pubmed/22636321,http://www.ncbi.nlm.nih.gov/pubmed/28167945,http://www.ncbi.nlm.nih.gov/pubmed/26578650,http://www.ncbi.nlm.nih.gov/pubmed/12183550,http://www.ncbi.nlm.nih.gov/pubmed/3929401,http://www.ncbi.nlm.nih.gov/pubmed/22566755 | Is Brucella abortus the organism that causes brucillosis known to cause spontaneous abortions in humans? | Human brucellosis symptoms and clinical signs most commonly reported are fever, fatigue, malaise, chills, sweats headaches, myalgia, arthralgia, and weight loss. Some cases have been presented with only joint pain, lower backache, and involuntary limb movement, burning feet, or ischemic heart attacks. |
http://www.ncbi.nlm.nih.gov/pubmed/18768141,http://www.ncbi.nlm.nih.gov/pubmed/24336922,http://www.ncbi.nlm.nih.gov/pubmed/27038113,http://www.ncbi.nlm.nih.gov/pubmed/23872234,http://www.ncbi.nlm.nih.gov/pubmed/27824859,http://www.ncbi.nlm.nih.gov/pubmed/26392408 | What percentage of Homo sapiens DNA is of Neanderthal origin? | We find that the power to reject ancient admixture might be particularly low if the population size of Homo sapiens was comparable to the Neanderthal population size. Our results indicate that 3.6% of the Neanderthal genome is shared with roughly 65.4% of the average European gene pool, which clinally diminishes with distance from Europe.Approximately 2-4% of genetic material in human populations outside Africa is derived from Neanderthals who interbred with anatomically modern humans. 3.6% of the Neanderthal genome is shared with roughly 65.4% of the average European gene pool, which clinally diminishes with distance from Europe.Our results indicate that 3.6% of the Neanderthal genome is shared with roughly 65.4% of the average European gene pool, which clinally diminishes with distance from Europe. Here, we present evidence of Neanderthal introgression within the chromosome 3p21.31 region, occurring with a high frequency in East Asians (ranging from 49.4% to 66.5%) and at a low frequency in Europeans.3.6 % of the neanderthal genome is shared with roughly 65.4 % of the average european gene pool , which clinally diminishes with distance from europe.This work suggests that differences in effective population size may play a far more important role in shaping levels of introgression than previously thought. |
http://www.ncbi.nlm.nih.gov/pubmed/17145384,http://www.ncbi.nlm.nih.gov/pubmed/28138723,http://www.ncbi.nlm.nih.gov/pubmed/21992150,http://www.ncbi.nlm.nih.gov/pubmed/28175956,http://www.ncbi.nlm.nih.gov/pubmed/28841903,http://www.ncbi.nlm.nih.gov/pubmed/18847012,http://www.ncbi.nlm.nih.gov/pubmed/28732844 | What is Dupuytren's contracture? | Dupuytren's contracture is a progressive hand condition that affects how much you can move or straighten your fingers. It is a benign fibroproliferative disease leads to hyperplasia of the collagen fibers of the fascia of the palm, which can result in severe impairment of the functionality of the hand. |
http://www.ncbi.nlm.nih.gov/pubmed/18366057,http://www.ncbi.nlm.nih.gov/pubmed/12851335,http://www.ncbi.nlm.nih.gov/pubmed/12851336,http://www.ncbi.nlm.nih.gov/pubmed/21615505,http://www.ncbi.nlm.nih.gov/pubmed/17616515,http://www.ncbi.nlm.nih.gov/pubmed/11030758,http://www.ncbi.nlm.nih.gov/pubmed/15972726,http://www.ncbi.nlm.nih.gov/pubmed/25794181,http://www.ncbi.nlm.nih.gov/pubmed/26042826,http://www.ncbi.nlm.nih.gov/pubmed/11672965,http://www.ncbi.nlm.nih.gov/pubmed/24045876,http://www.ncbi.nlm.nih.gov/pubmed/12006619,http://www.ncbi.nlm.nih.gov/pubmed/19924138,http://www.ncbi.nlm.nih.gov/pubmed/18637132,http://www.ncbi.nlm.nih.gov/pubmed/26103569 | What phenotype is associated with the V60L mutation in the human MC1R gene? | The characterization of the melanocortin 1 receptor (MC1R) expressed on human melanocytes and the findings that certain mutations in the POMC gene or the MC1R gene result in red hair phenotype underscore the significance of melanocortins and MC1R in regulating human pigmentation. We describe a minisequencing protocol for screening DNA samples for the presence of 12 mutations in the human melanocortin 1 receptor gene (MC1R), eight of which are associated with the red hair phenotype. The human MC1R gene is highly polymorphic and certain allelic variants of the gene are associated with red hair phenotype, melanoma and non-melanoma skin cancer. Thus, at least in Spain, regions at opposite ends of the incident UV-B radiation distribution show significantly different frequencies for the melanoma-risk allele V60L (a mutation also associated to red hair and fair skin and even blonde hair), with higher frequency of V60L at those regions of lower incident UV-B radiation. These loss-of-function mutations have been associated with red hair phenotype and increased risk for skin cancer. Alleles associated with the red hair color (RHC) phenotype and with the risk of melanoma were examined.Red hair is usually inherited as a recessive characteristic with the R151C, R160W, D294H, R142H, 86insA and 537insC alleles at this locus. The V60L variant, which is common in the population may act as a partially penetrant recessive allele. V60L is a mutation also associated to red hair and fair skin and even blonde hair.The V60L variant, which is common in the population may act as a partially penetrant recessive allele. Both of these Thr(111)/Ala(111) heterozygotes carried a single polymorphism of MC1R (one with the V92M variant and another with the V60L variant) different frequencies for the melanoma-risk allele V60L (a mutation also associated to red hair and fair skin and even blonde hair) Genetic association and cellular function of MC1R variant alleles in human pigmentation. |
http://www.ncbi.nlm.nih.gov/pubmed/28512144,http://www.ncbi.nlm.nih.gov/pubmed/27072897,http://www.ncbi.nlm.nih.gov/pubmed/24120762,http://www.ncbi.nlm.nih.gov/pubmed/28415797,http://www.ncbi.nlm.nih.gov/pubmed/27066066,http://www.ncbi.nlm.nih.gov/pubmed/26676747,http://www.ncbi.nlm.nih.gov/pubmed/27549742,http://www.ncbi.nlm.nih.gov/pubmed/27742610,http://www.ncbi.nlm.nih.gov/pubmed/22315229,http://www.ncbi.nlm.nih.gov/pubmed/28668119 | List proteins with HEAT repeats | mTOR,
TOG5,
DNA-PKcs,
HEATR1,
Rif1,
B56γ,
PR65/A,
SF3b155,
Pds5B |
http://www.ncbi.nlm.nih.gov/pubmed/21518760,http://www.ncbi.nlm.nih.gov/pubmed/27987332,http://www.ncbi.nlm.nih.gov/pubmed/21953463,http://www.ncbi.nlm.nih.gov/pubmed/28880013,http://www.ncbi.nlm.nih.gov/pubmed/23962426,http://www.ncbi.nlm.nih.gov/pubmed/29082276 | What is the aim of perfoming a "cycloheximide chase assay"? | Comparison of protein stability in eukaryotic cells has been achieved by cycloheximide, which is an inhibitor of protein biosynthesis due to its prevention in translational elongation. It is broadly used in cell biology in terms of determining the half-life of a given protein and has gained much popularity in cancer research. |
http://www.ncbi.nlm.nih.gov/pubmed/28733901,http://www.ncbi.nlm.nih.gov/pubmed/32722531,http://www.ncbi.nlm.nih.gov/pubmed/11188932,http://www.ncbi.nlm.nih.gov/pubmed/18331451,http://www.ncbi.nlm.nih.gov/pubmed/27018079,http://www.ncbi.nlm.nih.gov/pubmed/31316512,http://www.ncbi.nlm.nih.gov/pubmed/30665462,http://www.ncbi.nlm.nih.gov/pubmed/24095986,http://www.ncbi.nlm.nih.gov/pubmed/28930577,http://www.ncbi.nlm.nih.gov/pubmed/29071676,http://www.ncbi.nlm.nih.gov/pubmed/22200143,http://www.ncbi.nlm.nih.gov/pubmed/22982408,http://www.ncbi.nlm.nih.gov/pubmed/26198793,http://www.ncbi.nlm.nih.gov/pubmed/27296830,http://www.ncbi.nlm.nih.gov/pubmed/22648975,http://www.ncbi.nlm.nih.gov/pubmed/34069542,http://www.ncbi.nlm.nih.gov/pubmed/26667071,http://www.ncbi.nlm.nih.gov/pubmed/31840492,http://www.ncbi.nlm.nih.gov/pubmed/29054369,http://www.ncbi.nlm.nih.gov/pubmed/25398455,http://www.ncbi.nlm.nih.gov/pubmed/26393640,http://www.ncbi.nlm.nih.gov/pubmed/10984428,http://www.ncbi.nlm.nih.gov/pubmed/20145139,http://www.ncbi.nlm.nih.gov/pubmed/21645191,http://www.ncbi.nlm.nih.gov/pubmed/28095652,http://www.ncbi.nlm.nih.gov/pubmed/28718905,http://www.ncbi.nlm.nih.gov/pubmed/15346807,http://www.ncbi.nlm.nih.gov/pubmed/28446531 | What is an exosome? | Exosomes are a subset of extracellular vesicles (EVs) that have important roles in intercellular communication. They contain and carry bioactive molecules within their membranes which are delivered to target cells. |
http://www.ncbi.nlm.nih.gov/pubmed/24097306,http://www.ncbi.nlm.nih.gov/pubmed/28527813,http://www.ncbi.nlm.nih.gov/pubmed/25635462,http://www.ncbi.nlm.nih.gov/pubmed/21783031,http://www.ncbi.nlm.nih.gov/pubmed/20023155,http://www.ncbi.nlm.nih.gov/pubmed/24218635 | Are human enhancers or promoters evolving faster? | Our data further reveal that recently evolved enhancers can be associated with genes under positive selection, demonstrating the power of this approach for annotating regulatory adaptations in genomic sequences. We report that rapid evolution of enhancers is a universal feature of mammalian genomes. We report that rapid evolution of enhancers is a universal feature of mammalian genomes.Rapid evolution of enhancers is a universal feature of mammalian genomes. |
http://www.ncbi.nlm.nih.gov/pubmed/27895055,http://www.ncbi.nlm.nih.gov/pubmed/27789605,http://www.ncbi.nlm.nih.gov/pubmed/27626268 | What are the 3 antidotes for anticoagulant (anti-blood clotting) drugs, including factor Xa inhibitors, as of November 2017. | two potential reversal agents for oral direct factor Xa inhibitors (andexanet alfa and ciraparantag) are at various stages of clinical development. Idarucizumab, a reversal agent for the oral direct thrombin inhibitor dabigatran, was approved by FDA in October 2015. two potential reversal agents for oral direct factor Xa inhibitors (andexanet alfa and ciraparantag) are at various stages of clinical development. Idarucizumab, a reversal agent for the oral direct thrombin inhibitor dabigatran, was approved by FDA in October 2015. Idarucizumab and andexanet alfa have been reported to produce anticoagulation reversal effects within minutes of administration. Two potential reversal agents for oral direct factor Xa inhibitors (andexanet alfa and ciraparantag) are at various stages of clinical development. Idarucizumab, a reversal agent for the oral direct thrombin inhibitor dabigatran. Protamine sulfate reverses the effect of unfractionated heparin completely and of low-molecular-weight heparin (LMWH) partially. Aripazine has shown promising results to reverse the effects of LMWH, fondaparinux, and direct oral anticoagulants but is still in the developmental phase. |
http://www.ncbi.nlm.nih.gov/pubmed/19797037,http://www.ncbi.nlm.nih.gov/pubmed/7539246,http://www.ncbi.nlm.nih.gov/pubmed/9036937,http://www.ncbi.nlm.nih.gov/pubmed/10494094,http://www.ncbi.nlm.nih.gov/pubmed/7561171,http://www.ncbi.nlm.nih.gov/pubmed/21375516,http://www.ncbi.nlm.nih.gov/pubmed/11159198,http://www.ncbi.nlm.nih.gov/pubmed/1720261,http://www.ncbi.nlm.nih.gov/pubmed/9804355,http://www.ncbi.nlm.nih.gov/pubmed/22639907,http://www.ncbi.nlm.nih.gov/pubmed/26929861,http://www.ncbi.nlm.nih.gov/pubmed/20199538,http://www.ncbi.nlm.nih.gov/pubmed/11407988,http://www.ncbi.nlm.nih.gov/pubmed/8894687,http://www.ncbi.nlm.nih.gov/pubmed/20030639,http://www.ncbi.nlm.nih.gov/pubmed/8941634,http://www.ncbi.nlm.nih.gov/pubmed/1381443,http://www.ncbi.nlm.nih.gov/pubmed/12655565,http://www.ncbi.nlm.nih.gov/pubmed/28777847 | Which genes are associated with Epidermolysis Bullosa Simplex? | In one family studied, inheritance of EBS is linked to the gene encoding keratin 14Epidermolysis bullosa simplex (EBS) is mainly caused by mutations in the KRT5 and KRT14 genes. A compound heterozygous one amino-acid insertion/nonsense mutation in the plectin gene causes epidermolysis bullosa simplex with plectin deficiency.In one family studied, inheritance of EBS is linked to the gene encoding keratin 14 Homozygous deletion mutations in the plectin gene (PLEC1) in patients with epidermolysis bullosa simplex associated with late-onset muscular dystrophy. Epidermolysis bullosa simplex (EBS) is a rare genodermatosis resulting from multiple gene mutations, including KRT5 and KRT14.Epidermolysis bullosa simplex (EBS) is a rare genodermatosis resulting from multiple gene mutations, including KRT5 and KRT14.Keratin 5 and keratin 14 are known to be essential for the basal keratinocyte cytoskeleton and are defective in several forms of epidermolysis bullosa simplex. Homozygous deletion mutations in the plectin gene in patients with epidermolysis bullosa simplex associated with late-onset muscular dystrophy. The KRT5 and KRT14 genes encode the proteins keratin 5 and 14, respectively, which are the primary structural components of the 10-nm intermediate filaments of the mitotic epidermal basal cells. Epidermolysis bullosa simplex is mainly caused by mutations in the KRT5 and KRT14 genes. Verrucous carcinoma in epidermolysis bullosa simplex is possibly associated with a novel mutation in the keratin 5 gene. This is the first report of EBS-generalized intermediate in a newborn with de novo KRT5 gene mutation and KRT14 gene polymorphism, and no familial history of epidermolysis. Study of a family with epidermolysis bullosa simplex resulting from a novel mutation of KRT14 gene. We have systematically scanned genomic sequences of one of these keratins, keratin 14, for mutations in patients from 49 apparently independent kindreds using single-strand conformation polymorphism analysis. Homozygous deletion mutations in the plectin gene (PLEC1) in patients with epidermolysis bullosa simplex associated with late-onset muscular dystrophy. Epidermolysis bullosa simplex (EBS) is mainly caused by mutations in the KRT5 and KRT14 genes. Verrucous carcinoma in epidermolysis bullosa simplex is possibly associated with a novel mutation in the keratin 5 gene.Recent advances in molecular biology have enabled the association of epidermolysis bullosa simplex (EBS) with point mutations of keratin 14 and/or keratin 5 genes to be established. Keratin 14 gene mutations in patients with epidermolysis bullosa simplex. Mutant keratins 5 or 14 are implicated in the etiology of epidermolysis bullosa simplex (EBS). Keratin 14 gene point mutation in the Köbner and Dowling-Meara types of epidermolysis bullosa simplex as detected by the PASA method. |
http://www.ncbi.nlm.nih.gov/pubmed/15480318,http://www.ncbi.nlm.nih.gov/pubmed/27619824,http://www.ncbi.nlm.nih.gov/pubmed/16964309,http://www.ncbi.nlm.nih.gov/pubmed/27288329,http://www.ncbi.nlm.nih.gov/pubmed/11447391,http://www.ncbi.nlm.nih.gov/pubmed/27381924,http://www.ncbi.nlm.nih.gov/pubmed/9354811,http://www.ncbi.nlm.nih.gov/pubmed/27302551,http://www.ncbi.nlm.nih.gov/pubmed/24382176,http://www.ncbi.nlm.nih.gov/pubmed/28439090,http://www.ncbi.nlm.nih.gov/pubmed/17468237,http://www.ncbi.nlm.nih.gov/pubmed/17386403,http://www.ncbi.nlm.nih.gov/pubmed/6178551,http://www.ncbi.nlm.nih.gov/pubmed/24342726,http://www.ncbi.nlm.nih.gov/pubmed/16141514,http://www.ncbi.nlm.nih.gov/pubmed/24903914,http://www.ncbi.nlm.nih.gov/pubmed/9060446 | What biologic process in the body is associated with Mast cells? | Mast cells (MCs) are innate immune cells that are a major source of costimulatory signals and inflammatory mediators in the intestinal mucosa. Mast cells are significantly involved in IgE-mediated allergic reactions but may be involved in defense against parasites as well as other immune mediated diseases including heart diseaseMast cells (MCs) are innate immune cells that are a major source of costimulatory signals and inflammatory mediators in the intestinal mucosa |
http://www.ncbi.nlm.nih.gov/pubmed/24891049,http://www.ncbi.nlm.nih.gov/pubmed/16117741,http://www.ncbi.nlm.nih.gov/pubmed/23834148,http://www.ncbi.nlm.nih.gov/pubmed/11100018 | What are the 3 types of ultraviolet (UV) solar radiation? | Solar ultraviolet (UV) radiation, an ubiquitous environmental carcinogen, is classified depending on the wavelength, into three regions; short-wave UVC (200-280 nm), mid-wave UVB (280-320 nm), and long-wave UVA (320- 400 nm)short-wave UVC (200-280 nm), medium-wave UVB (280-320 nm), and long-wave UVA (320-400 nm).short-wave UVC (200-280 nm), medium-wave UVB (280-320 nm), and long-wave UVA (320-400 nm). |
http://www.ncbi.nlm.nih.gov/pubmed/25430048,http://www.ncbi.nlm.nih.gov/pubmed/21072908,http://www.ncbi.nlm.nih.gov/pubmed/14688506,http://www.ncbi.nlm.nih.gov/pubmed/8149754,http://www.ncbi.nlm.nih.gov/pubmed/28822529,http://www.ncbi.nlm.nih.gov/pubmed/12001826,http://www.ncbi.nlm.nih.gov/pubmed/19450312,http://www.ncbi.nlm.nih.gov/pubmed/27247004,http://www.ncbi.nlm.nih.gov/pubmed/11975840,http://www.ncbi.nlm.nih.gov/pubmed/28496617,http://www.ncbi.nlm.nih.gov/pubmed/2200378,http://www.ncbi.nlm.nih.gov/pubmed/21718559,http://www.ncbi.nlm.nih.gov/pubmed/3158290,http://www.ncbi.nlm.nih.gov/pubmed/25994013,http://www.ncbi.nlm.nih.gov/pubmed/19151857,http://www.ncbi.nlm.nih.gov/pubmed/7846937,http://www.ncbi.nlm.nih.gov/pubmed/22075545,http://www.ncbi.nlm.nih.gov/pubmed/27957098,http://www.ncbi.nlm.nih.gov/pubmed/12395441,http://www.ncbi.nlm.nih.gov/pubmed/10535368,http://www.ncbi.nlm.nih.gov/pubmed/10505494,http://www.ncbi.nlm.nih.gov/pubmed/28496833,http://www.ncbi.nlm.nih.gov/pubmed/19450316 | Please list 10 conditions which play a role in causing atrial fibrillation. | Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with significant morbidity and mortality. Multiple conditions like hypertension, heart failure, diabetes, sleep apnoea, hyperthyroidism and obesity play a role for the initiation and perpetuation of AF. Other possible causes are alcohol and drug use and atrial ischemia. Risk of AF increases with age. |
http://www.ncbi.nlm.nih.gov/pubmed/27990773,http://www.ncbi.nlm.nih.gov/pubmed/28140789,http://www.ncbi.nlm.nih.gov/pubmed/27216701 | Is p53 a transcription factor? | Yes, p53 is a sequence-specific transcription factor. |
http://www.ncbi.nlm.nih.gov/pubmed/28694499 | Is Cystatin D a biomarker? | Cystatin D (CST5): An ultra-early inflammatory biomarker of traumatic brain injury |
http://www.ncbi.nlm.nih.gov/pubmed/28034363,http://www.ncbi.nlm.nih.gov/pubmed/24105765,http://www.ncbi.nlm.nih.gov/pubmed/25714343,http://www.ncbi.nlm.nih.gov/pubmed/16477557,http://www.ncbi.nlm.nih.gov/pubmed/24946952,http://www.ncbi.nlm.nih.gov/pubmed/15259461,http://www.ncbi.nlm.nih.gov/pubmed/20145708,http://www.ncbi.nlm.nih.gov/pubmed/16436699,http://www.ncbi.nlm.nih.gov/pubmed/25116660,http://www.ncbi.nlm.nih.gov/pubmed/15071036,http://www.ncbi.nlm.nih.gov/pubmed/24707415,http://www.ncbi.nlm.nih.gov/pubmed/23219435,http://www.ncbi.nlm.nih.gov/pubmed/29058760,http://www.ncbi.nlm.nih.gov/pubmed/15135858,http://www.ncbi.nlm.nih.gov/pubmed/25988048,http://www.ncbi.nlm.nih.gov/pubmed/23868744,http://www.ncbi.nlm.nih.gov/pubmed/23286822,http://www.ncbi.nlm.nih.gov/pubmed/25228325,http://www.ncbi.nlm.nih.gov/pubmed/11175518,http://www.ncbi.nlm.nih.gov/pubmed/19002608,http://www.ncbi.nlm.nih.gov/pubmed/26989711,http://www.ncbi.nlm.nih.gov/pubmed/2670376,http://www.ncbi.nlm.nih.gov/pubmed/24039881,http://www.ncbi.nlm.nih.gov/pubmed/28903998 | What causes leishmaniasis? | Leishmania spp. is a group of very successful protozoan parasites that cause a range of diseases from self-healing cutaneous leishmaniasis to visceral leishmaniasis. |
http://www.ncbi.nlm.nih.gov/pubmed/24038065,http://www.ncbi.nlm.nih.gov/pubmed/17698824,http://www.ncbi.nlm.nih.gov/pubmed/15911722,http://www.ncbi.nlm.nih.gov/pubmed/18315779,http://www.ncbi.nlm.nih.gov/pubmed/20095918,http://www.ncbi.nlm.nih.gov/pubmed/17119104,http://www.ncbi.nlm.nih.gov/pubmed/19934391,http://www.ncbi.nlm.nih.gov/pubmed/23033232,http://www.ncbi.nlm.nih.gov/pubmed/22198820,http://www.ncbi.nlm.nih.gov/pubmed/23089199,http://www.ncbi.nlm.nih.gov/pubmed/6347619,http://www.ncbi.nlm.nih.gov/pubmed/8792056,http://www.ncbi.nlm.nih.gov/pubmed/27416928,http://www.ncbi.nlm.nih.gov/pubmed/8672833,http://www.ncbi.nlm.nih.gov/pubmed/15585436,http://www.ncbi.nlm.nih.gov/pubmed/21332566,http://www.ncbi.nlm.nih.gov/pubmed/27365092,http://www.ncbi.nlm.nih.gov/pubmed/23045839 | Please list 7 classes of drugs that interact with Warfarin. | The number of drugs reported to interact with warfarin continues to expand. There are reports of interactions with azole antibiotics, macrolides, quinolones, nonsteroidal anti-inflammatory drugs, including selective cyclooxygenase-2 inhibitors, selective serotonin reuptake inhibitors, omeprazole, lipid-lowering agents, protease inhibitors, amiodarone, fluorouracil, psychotropics, and oral corticosteroids.Seven drugs/drug classes (ibuprofen, morphine, warfarin, bupropion, paroxetine, rosiglitazone, ACE inhibitors) with known ADEs were selected to evaluate the system. This study was aimed to determine the prevalence of drug-related problems (DRPs), identify the most common drugs, and drug classes involved in DRPs as well as associated factors with the occurrence of DRPs.A prospective cross-sectional study was conducted on 225 patients admitted to medical wards of Tikur Anbessa Specialized Hospital, Addis Ababa from March to June 2014. Analysis of the data showed that albumin possesses a single strong binding site for warfarin with an association constant of 154,000 at 3 degrees C and secondary classes of several sites with a much lower affinity. Four medications or medication classes were implicated alone or in combination in 67.0% (95% CI, 60.0 to 74.1) of hospitalizations: warfarin (33.3%), insulins (13.9%), oral antiplatelet agents (13.3%), and oral hypoglycemic agents (10.7%). Drugs such as gentamycin, warfarin, nifedipine, and cimetidine have the highest probability of causing DRP. Drugs with the highest drug risk ratio were gentamycin, warfarin, nifedipine, and cimetidine. The drugs most frequently causing a DRP were angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers, diuretics, warfarin, spironolactone, and β-blockers. |
http://www.ncbi.nlm.nih.gov/pubmed/28042777,http://www.ncbi.nlm.nih.gov/pubmed/28007619,http://www.ncbi.nlm.nih.gov/pubmed/27431778 | What part of the body is affected by mesotheliomia? | Mesothelioma is a type of cancer that develops from the thin layer of tissue that covers many of the internal organs (known as the mesothelium). The most common area affected is the lining of the lungs and chest wall.Malignant pleural mesothelioma (MPM) is a hard to treat malignancy arising from the mesothelial surface of the pleura. Malignant pleural mesothelioma (MPM) is a hard to treat malignancy arising from the mesothelial surface of the pleura. |
http://www.ncbi.nlm.nih.gov/pubmed/10834971,http://www.ncbi.nlm.nih.gov/pubmed/2069374,http://www.ncbi.nlm.nih.gov/pubmed/17108271,http://www.ncbi.nlm.nih.gov/pubmed/28893360,http://www.ncbi.nlm.nih.gov/pubmed/2261916,http://www.ncbi.nlm.nih.gov/pubmed/25352679,http://www.ncbi.nlm.nih.gov/pubmed/1563385,http://www.ncbi.nlm.nih.gov/pubmed/18630132,http://www.ncbi.nlm.nih.gov/pubmed/21875361,http://www.ncbi.nlm.nih.gov/pubmed/18819540,http://www.ncbi.nlm.nih.gov/pubmed/19116360,http://www.ncbi.nlm.nih.gov/pubmed/20880412,http://www.ncbi.nlm.nih.gov/pubmed/26679725 | What is BORSA? | Borderline oxacillin-resistant Staphylococcus aureus is also known as (BORSA)Borderline oxacillin-resistant Staphylococcus aureus (BORSA)Borderline oxacillin-resistant Staphylococcus aureus (BORSA). |
http://www.ncbi.nlm.nih.gov/pubmed/15983371,http://www.ncbi.nlm.nih.gov/pubmed/26980647,http://www.ncbi.nlm.nih.gov/pubmed/25269856,http://www.ncbi.nlm.nih.gov/pubmed/17033973,http://www.ncbi.nlm.nih.gov/pubmed/12876151,http://www.ncbi.nlm.nih.gov/pubmed/26212494,http://www.ncbi.nlm.nih.gov/pubmed/21108403,http://www.ncbi.nlm.nih.gov/pubmed/27148578 | Which gene is responsible for proper speech development? | Transcription factor forkhead box protein P2 (FOXP2) plays an essential role in the development of language and speech.The Key Regulator for Language and Speech Development, FOXP2, is a Novel Substrate for SUMOylation.The Key Regulator for Language and Speech Development, FOXP2, is a Novel Substrate for SUMOylation. The data also point to a role for differential parent-of-origin expression of FOXP2 in human speech development.Transcription factor forkhead box protein p2 plays an essential role in the development of language and speech.The key regulator for language and speech development , foxp2 , is a novel substrate for sumoylation.The Key Regulator for Language and Speech Development, FOXP2, is a Novel Substrate for SUMOylation. Transcription factor forkhead box protein P2 (FOXP2) plays an essential role in the development of language and speech. |
http://www.ncbi.nlm.nih.gov/pubmed/26551787 | What is PNPPP? | personally normalized plasma protein profiles (PNPPP) |
http://www.ncbi.nlm.nih.gov/pubmed/26282889,http://www.ncbi.nlm.nih.gov/pubmed/27846416 | What is Mendelian randomization? | Instrumental variable analysis is an approach for obtaining causal inferences on the effect of an exposure (risk factor) on an outcome from observational data. It has gained in popularity over the past decade with the use of genetic variants as instrumental variables, known as Mendelian randomization. |
http://www.ncbi.nlm.nih.gov/pubmed/28293123 | What does the pembrolizumab companion diagnostic test assess? | Administration of pembrolizumab requires a companion diagnostic test, to assess PD-L1 status of patients. |
http://www.ncbi.nlm.nih.gov/pubmed/24161931 | What is the combined effect of Nfat and miR-25? | Increased calcineurin/Nfat signalling and decreased miR-25 expression integrate to re-express the basic helix-loop-helix (bHLH) transcription factor dHAND (also known as Hand2) in the diseased human and mouse myocardium. |
http://www.ncbi.nlm.nih.gov/pubmed/28081177,http://www.ncbi.nlm.nih.gov/pubmed/28062617,http://www.ncbi.nlm.nih.gov/pubmed/28025863,http://www.ncbi.nlm.nih.gov/pubmed/27750354,http://www.ncbi.nlm.nih.gov/pubmed/28159780 | In what states are GDF15 expression increased? | Growth differentiation factor 15 (GDF-15) is expressed and secreted in response to inflammation, oxidative stress, hypoxia, telomere erosion, and oncogene activation. |
http://www.ncbi.nlm.nih.gov/pubmed/9689229,http://www.ncbi.nlm.nih.gov/pubmed/15947908,http://www.ncbi.nlm.nih.gov/pubmed/12399934,http://www.ncbi.nlm.nih.gov/pubmed/26818075,http://www.ncbi.nlm.nih.gov/pubmed/16717285,http://www.ncbi.nlm.nih.gov/pubmed/21276256 | Which genomic positions are preferentially selected for transposon insertion? | Preferential integration occurs in non-coding DNA and heterochromatin. A preference for structural features in the target DNA associated with DNA flexibility (Twist, Tilt, Rise, Roll, Shift, and Slide) was also observed. |
http://www.ncbi.nlm.nih.gov/pubmed/29106446 | Which Lisp framework has been developed for image processing? | FunImageJ is a Lisp framework for scientific image processing built upon the ImageJ software ecosystem. The framework provides a natural functional-style for programming, while accounting for the performance requirements necessary in big data processing commonly encountered in biological image analysis. |
http://www.ncbi.nlm.nih.gov/pubmed/25501636,http://www.ncbi.nlm.nih.gov/pubmed/24572763 | Which gene controls the consistency of cerumen (ear wax)? | A single nucleotide polymorphism (SNP) in ABCC11 affects the cerumen VOC profiles of individuals from African, Caucasian, and Asian descent Our findings also reveal that ABCC11 genotype alone does not predict the type and relative levels of volatiles found in human cerumen, and suggest that other biochemical pathways must be involvedA single nucleotide polymorphism (SNP) in ABCC11 affects the cerumen VOC profiles of individuals from African, Caucasian, and Asian descentA single nucleotide polymorphism (SNP) in ABCC11 affects the cerumen VOC profiles of individuals from African, Caucasian, and Asian descent ABCC11 encodes an ATP-driven efflux pump protein that plays an important function in ceruminous apocrine glands of the auditory canal and the secretion of axillary odor precursors.Recent studies link a single nucleotide polymorphism (SNP) in the adenosine triphosphate (ATP) binding cassette, sub-family C, member 11 gene (ABCC11) to the production of different types of axillary odorants and cerumen. ABCC11 encodes an ATP-driven efflux pump protein that plays an important function in ceruminous apocrine glands of the auditory canal and the secretion of axillary odor precursors. |
http://www.ncbi.nlm.nih.gov/pubmed/25398740 | What is the origin of human breast milk bacteria? | It is believed that certain bacteria from the maternal gastrointestinal tract could translocate through a mechanism involving mononuclear immune cells, migrate to the mammary glands via an endogenous cellular route (the bacterial entero-mammary pathway), and subsequently colonize the gastrointestinal tract of the breast-fed neonate |
http://www.ncbi.nlm.nih.gov/pubmed/26957392,http://www.ncbi.nlm.nih.gov/pubmed/24793967,http://www.ncbi.nlm.nih.gov/pubmed/29665796,http://www.ncbi.nlm.nih.gov/pubmed/25711611,http://www.ncbi.nlm.nih.gov/pubmed/27495089 | Which species is the carrier of the SFTS ( severe fever with thrombocytopenia syndrome) virus? | The possibility that SFTSV transmission may occur by both the transstadial and transovarial routes was suggested by the fact that viral RNA was detected in Haemaphysalis longicornis at all developmental stages. Tick-derived sequences shared over 95.6% identity with human- and animal-derived isolates. This study provides evidence that implicates ticks as not only vectors but also, reservoirs of SFTSV.Seroprevalence in animal species were: goats (66.8%), cattle (28.2%), dogs (7.4%), pigs (4.7%), chickens (1.2%), geese (1.7%), rodents (4.4%) and hedgehogs (2.7%). The possibility that SFTSV transmission may occur by both the transstadial and transovarial routes was suggested by the fact that viral RNA was detected in H. longicornis at all developmental stages. Tick-derived sequences shared over 95.6% identity with human- and animal-derived isolates.The possibility that SFTSV transmission may occur by both the transstadial and transovarial routes was suggested by the fact that viral RNA was detected in H. longicornis at all developmental stages. Severe fever with thrombocytopenia syndrome (SFTS) is a new emerging zoonosis. |
http://www.ncbi.nlm.nih.gov/pubmed/24523241,http://www.ncbi.nlm.nih.gov/pubmed/19956569,http://www.ncbi.nlm.nih.gov/pubmed/12692554,http://www.ncbi.nlm.nih.gov/pubmed/29715199,http://www.ncbi.nlm.nih.gov/pubmed/28928741,http://www.ncbi.nlm.nih.gov/pubmed/29057173,http://www.ncbi.nlm.nih.gov/pubmed/29066537,http://www.ncbi.nlm.nih.gov/pubmed/28768817,http://www.ncbi.nlm.nih.gov/pubmed/29659363,http://www.ncbi.nlm.nih.gov/pubmed/21178277,http://www.ncbi.nlm.nih.gov/pubmed/18274673,http://www.ncbi.nlm.nih.gov/pubmed/21506920,http://www.ncbi.nlm.nih.gov/pubmed/28512628,http://www.ncbi.nlm.nih.gov/pubmed/23009155,http://www.ncbi.nlm.nih.gov/pubmed/22596258,http://www.ncbi.nlm.nih.gov/pubmed/22748845,http://www.ncbi.nlm.nih.gov/pubmed/16899028,http://www.ncbi.nlm.nih.gov/pubmed/14612668 | List four features of the WHIM syndrome. | The Warts, Hypogammaglobulinemia, Infections, Myelokathexis (WHIM) syndrome is an immunodeficiency caused by mutations in chemokine receptor CXCR4. |
http://www.ncbi.nlm.nih.gov/pubmed/30359297 | Which algorithm has been developed for the automatic extraction of co-expressed gene clusters from gene expression data? | Clust is a method for automatic extraction of optimal co-expressed gene clusters from gene expression data. Clust is available at https://github.com/BaselAbujamous/clust. |
http://www.ncbi.nlm.nih.gov/pubmed/28381231 | Which bacteria are enriched in the gut microbiome of infants following exposure to fury pets? | Pre- and postnatal pet exposure enriched the abundance of Oscillospira and/or Ruminococcus in infants. |
http://www.ncbi.nlm.nih.gov/pubmed/27492077,http://www.ncbi.nlm.nih.gov/pubmed/25622637,http://www.ncbi.nlm.nih.gov/pubmed/10786290,http://www.ncbi.nlm.nih.gov/pubmed/27980099,http://www.ncbi.nlm.nih.gov/pubmed/17503393,http://www.ncbi.nlm.nih.gov/pubmed/26228302,http://www.ncbi.nlm.nih.gov/pubmed/15531608,http://www.ncbi.nlm.nih.gov/pubmed/26620522 | List the main PPI databases. | PPIM,
HPRD,
STRING,
DAPID,
MIPS,
INTERACT,
BioGRID |
http://www.ncbi.nlm.nih.gov/pubmed/30395523,http://www.ncbi.nlm.nih.gov/pubmed/30316915,http://www.ncbi.nlm.nih.gov/pubmed/29623652,http://www.ncbi.nlm.nih.gov/pubmed/30184455,http://www.ncbi.nlm.nih.gov/pubmed/30476172,http://www.ncbi.nlm.nih.gov/pubmed/30396860,http://www.ncbi.nlm.nih.gov/pubmed/30203386,http://www.ncbi.nlm.nih.gov/pubmed/29941893 | Is Baloxavir effective for influenza? | Yes. Baloxavir is approved for influenza A or B virus infections. |
http://www.ncbi.nlm.nih.gov/pubmed/29124969 | Which member of the human mycobiota is associated to atherosclerosis? | Mucor racemosus is negatively associated with carotid atherosclerosis |
http://www.ncbi.nlm.nih.gov/pubmed/12417197,http://www.ncbi.nlm.nih.gov/pubmed/29301859,http://www.ncbi.nlm.nih.gov/pubmed/22921757,http://www.ncbi.nlm.nih.gov/pubmed/21455272 | List intramembrane rhomboid peptidases | PARL
Pcp1
hiGlpG
ecGlpG
YqgP |
http://www.ncbi.nlm.nih.gov/pubmed/30190407,http://www.ncbi.nlm.nih.gov/pubmed/11099133 | Where is the protein Bouncer located? | Bouncer is membrane bound. |
http://www.ncbi.nlm.nih.gov/pubmed/16527865,http://www.ncbi.nlm.nih.gov/pubmed/20820472,http://www.ncbi.nlm.nih.gov/pubmed/17494770,http://www.ncbi.nlm.nih.gov/pubmed/15004568,http://www.ncbi.nlm.nih.gov/pubmed/17194778,http://www.ncbi.nlm.nih.gov/pubmed/21546358 | How many genes in S. cerevisiae are the result of an ancient whole genome duplication? | The two genomes subsequently converged onto similar current sizes (5,600 protein-coding genes each) and independently retained sets of duplicated genes that are strikingly similar. Almost half of their surviving single-copy genes are not orthologs but paralogs formed by WGD, as would be expected if most gene pairs were resolved independently. |
http://www.ncbi.nlm.nih.gov/pubmed/27803011,http://www.ncbi.nlm.nih.gov/pubmed/24559541,http://www.ncbi.nlm.nih.gov/pubmed/17179719 | Which intoxication is associated with Burton's line? | Burton's line is characteristic for lead poisoning. |
http://www.ncbi.nlm.nih.gov/pubmed/29096012 | Which tool has been developed for coverage calculation for genomes? | Mosdepth is a command-line tool for rapidly calculating genome-wide sequencing coverage. It measures depth from BAM or CRAM files at either each nucleotide position in a genome or for sets of genomic regions. Genomic regions may be specified as either a BED file to evaluate coverage across capture regions, or as a fixed-size window as required for copy-number calling. Mosdepth uses a simple algorithm that is computationally efficient and enables it to quickly produce coverage summaries.Mosdepth is a new command-line tool for rapidly calculating genome-wide sequencing coverage. It measures depth from BAM or CRAM files at either each nucleotide position in a genome or for sets of genomic regions. |
http://www.ncbi.nlm.nih.gov/pubmed/26146997 | Which type of sarcoma has been associated with members of the oral microbiome? | Alterations in the oral microbiota in the immunosuppressed population may be associated with diseases such as Kaposi's sarcoma. |
http://www.ncbi.nlm.nih.gov/pubmed/23508100,http://www.ncbi.nlm.nih.gov/pubmed/23169531,http://www.ncbi.nlm.nih.gov/pubmed/22143885,http://www.ncbi.nlm.nih.gov/pubmed/24929238 | Which complex is bound by estrogen-related receptor β (Esrrb)? | Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells.Knockdown of Mp1 redirected FGF4 signaling from differentiation toward pluripotency and up-regulated the pluripotency-related genes Esrrb, Rex1, Tcl1, and Sox2. Dax1 associates with Esrrb and regulates its function in embryonic stem cells. Here, we identified an orphan nuclear receptor, Esrrb (estrogen-related receptor beta), as a Dax1-interacting protein. |
http://www.ncbi.nlm.nih.gov/pubmed/28019079 | Which approach was used to diagnose a patient with Cutis Verticis Gyrata-Intellectual Disability (CVG-ID) syndrome? | Magnetic Resonance Imaging (MRI) |
http://www.ncbi.nlm.nih.gov/pubmed/30456447,http://www.ncbi.nlm.nih.gov/pubmed/30377167,http://www.ncbi.nlm.nih.gov/pubmed/29863979,http://www.ncbi.nlm.nih.gov/pubmed/29934319 | Cemiplimab is used for treatment of which cancer? | Cemiplimab is a PD-1 inhibitor that is approved for treatment of metastatic or locally advanced cutaneous squamous cell carcinoma. |
http://www.ncbi.nlm.nih.gov/pubmed/25415278 | Which cancer has the kynureninase pathway been associated to? | The kynurenine pathway has been associated with human glioma pathophysiology. |
http://www.ncbi.nlm.nih.gov/pubmed/25186992,http://www.ncbi.nlm.nih.gov/pubmed/7588946,http://www.ncbi.nlm.nih.gov/pubmed/19758166,http://www.ncbi.nlm.nih.gov/pubmed/21767292,http://www.ncbi.nlm.nih.gov/pubmed/28355987,http://www.ncbi.nlm.nih.gov/pubmed/24268009 | Which organs are mostly affected in Systemic Lupus Erythematosus (SLE)? | In systemic lupus erythematosus (SLE), brain and kidney are the most frequently affected organs. The heart is one of the most frequently affected organs in SLE. Skin is one of the most commonly affected organs in SLE. Other affected organs in SLE-AAC included hematologic system (11, 84.6%), followed by mucocutaneous (seven, 53.8%), musculoskeletal (seven, 53.8%) and neuropsychiatric (two, 15.4%) systems.In systemic lupus erythematosus (SLE), brain and kidney are the most frequently affected organs. The heart is one of the most frequently affected organs in SLE. Skin is one of the most commonly affected organs in SLEIn systemic lupus erythematosus (SLE), brain and kidney are the most frequently affected organs. The heart is one of the most frequently affected organs in SLE. Any part of the heart can be affected, including the pericardium, myocardium, coronary arteries, valves, and the conduction systemIn systemic lupus erythematosus (SLE), brain and kidney are the most frequently affected organs. |
http://www.ncbi.nlm.nih.gov/pubmed/29027702,http://www.ncbi.nlm.nih.gov/pubmed/29393895,http://www.ncbi.nlm.nih.gov/pubmed/29255114,http://www.ncbi.nlm.nih.gov/pubmed/30094187 | What is a GPI anchor? | Glycosylphosphatidylinositol (GPI) anchoring of proteins is a conserved posttranslational modification in the endoplasmic reticulum (ER). Glycosylphosphatidylinositols (GPIs) are lipid anchors allowing the exposure of proteins at the outer layer of the plasma membrane. |
http://www.ncbi.nlm.nih.gov/pubmed/26984631,http://www.ncbi.nlm.nih.gov/pubmed/29425851,http://www.ncbi.nlm.nih.gov/pubmed/29113828,http://www.ncbi.nlm.nih.gov/pubmed/23340289,http://www.ncbi.nlm.nih.gov/pubmed/28752494 | In which way does DNA hydroxymethylation affect patients with Systemic Lupus Erythematosus? | DNA hydroxymethylation contributes to the aberrant regulation of genes transcription in the pathogenesis of SLE. A combined analysis of differential DNA hydroxymethylation profile and gene expression profile in SLE CD4(+) T cells, shows 131 genes with increased 5-hmC in promoter regions and up-regulated expression in SLE CD4(+) T cells compared with healthy controls, including selected immune-related genes, i.e. SOCS1, NR2F6 and IL15RA.Altered DNA methylation and hydroxymethylation as well as histone modifications mediate changes in chromatin accessibility and gene expression in immune cells from SLE patients. 5-Hydroxymethylcytosine (5-hmC) is a newly discovered modified form of cytosine suspected to be an important epigenetic modification in embryonic development, cell differentiation and cancer. |
http://www.ncbi.nlm.nih.gov/pubmed/21300291,http://www.ncbi.nlm.nih.gov/pubmed/20174964,http://www.ncbi.nlm.nih.gov/pubmed/15909992 | What is the function of PAPOLA/PAP? | Poly(A)polymerase-alpha (PAPOLA) has been the most extensively investigated mammalian polyadenylating enzyme, mainly in regard to its multifaceted post-translational regulation. PolyA polymerase (PAP) adds a polyA tail onto the 3'-end of RNAs without a nucleic acid template, using adenosine-5'-triphosphate (ATP) as a substrate. |
http://www.ncbi.nlm.nih.gov/pubmed/24489730,http://www.ncbi.nlm.nih.gov/pubmed/28639200,http://www.ncbi.nlm.nih.gov/pubmed/22872227 | List 3 diseases for which saRNAs have been evaluated as a potential treatment. | saRNAs have been tested for the treatment of breast, bladder, liver cancer and more. |
http://www.ncbi.nlm.nih.gov/pubmed/29256901,http://www.ncbi.nlm.nih.gov/pubmed/29174221,http://www.ncbi.nlm.nih.gov/pubmed/28475456,http://www.ncbi.nlm.nih.gov/pubmed/29119148,http://www.ncbi.nlm.nih.gov/pubmed/30394941,http://www.ncbi.nlm.nih.gov/pubmed/27780853,http://www.ncbi.nlm.nih.gov/pubmed/29403310,http://www.ncbi.nlm.nih.gov/pubmed/28435288,http://www.ncbi.nlm.nih.gov/pubmed/29935304,http://www.ncbi.nlm.nih.gov/pubmed/30191596,http://www.ncbi.nlm.nih.gov/pubmed/30251885,http://www.ncbi.nlm.nih.gov/pubmed/30253203,http://www.ncbi.nlm.nih.gov/pubmed/29856687,http://www.ncbi.nlm.nih.gov/pubmed/29187012,http://www.ncbi.nlm.nih.gov/pubmed/27144831,http://www.ncbi.nlm.nih.gov/pubmed/28597393,http://www.ncbi.nlm.nih.gov/pubmed/28536155,http://www.ncbi.nlm.nih.gov/pubmed/29032042 | What is the mechanism of action of Brigatinib? | Brigatinib targets anaplastic lymphoma kinase. It is used for treatment of lung cancer (NSCLC). |
http://www.ncbi.nlm.nih.gov/pubmed/27789693 | Which database associates human noncoding SNPs with their three-dimensional interacting genes? | 3DSNP is a database for linking human noncoding SNPs to their three-dimensional interacting genes. It a valuable resource for the annotation of human noncoding genome sequence and investigating the impact of noncoding variants on clinical phenotypes. |
http://www.ncbi.nlm.nih.gov/pubmed/25431273 | In which phase of clinical trials was sutezolid in 2018? | By 2018 sutezolid had been evaluated in phase II clinical trials. |
http://www.ncbi.nlm.nih.gov/pubmed/29984580,http://www.ncbi.nlm.nih.gov/pubmed/28726036,http://www.ncbi.nlm.nih.gov/pubmed/28107612 | What is gingipain? | Porphyromonas gingivalis is a keystone periodontal pathogen that has been associated with autoimmune disorders. The cell surface proteases Lys-gingipain (Kgp) and Arg-gingipains (RgpA and RgpB) are major virulence factors, and their proteolytic activity is enhanced by small peptides such as glycylglycine (GlyGly). |
http://www.ncbi.nlm.nih.gov/pubmed/27280980 | For which disease is sutezolid developed? | Sutezolid is being developed as a treatment against tuberculosis. |
http://www.ncbi.nlm.nih.gov/pubmed/28483959 | What does gepotidacin do to bacteria? | Gepotidacin inhibits bacterial DNA replication. |
http://www.ncbi.nlm.nih.gov/pubmed/12056818,http://www.ncbi.nlm.nih.gov/pubmed/30503518 | What is the role of fucokinase? | FUK encodes fucokinase, the only enzyme capable of converting L-fucose to fucose-1-phosphate, which will ultimately be used for synthesizing GDP-fucose, the donor substrate for all fucosyltransferases. |
http://www.ncbi.nlm.nih.gov/pubmed/27940404 | Are there microbes in human breast milk? | Yes, human milk is a rich source of diverse bacteria. |
http://www.ncbi.nlm.nih.gov/pubmed/28843918,http://www.ncbi.nlm.nih.gov/pubmed/24048386,http://www.ncbi.nlm.nih.gov/pubmed/23361832,http://www.ncbi.nlm.nih.gov/pubmed/27190727,http://www.ncbi.nlm.nih.gov/pubmed/30323605,http://www.ncbi.nlm.nih.gov/pubmed/27396597,http://www.ncbi.nlm.nih.gov/pubmed/28343051,http://www.ncbi.nlm.nih.gov/pubmed/27274384,http://www.ncbi.nlm.nih.gov/pubmed/28478771,http://www.ncbi.nlm.nih.gov/pubmed/27059102,http://www.ncbi.nlm.nih.gov/pubmed/29017067,http://www.ncbi.nlm.nih.gov/pubmed/26586950,http://www.ncbi.nlm.nih.gov/pubmed/25562205,http://www.ncbi.nlm.nih.gov/pubmed/23966785,http://www.ncbi.nlm.nih.gov/pubmed/25056368,http://www.ncbi.nlm.nih.gov/pubmed/30470662,http://www.ncbi.nlm.nih.gov/pubmed/26510944,http://www.ncbi.nlm.nih.gov/pubmed/29119668,http://www.ncbi.nlm.nih.gov/pubmed/26655189,http://www.ncbi.nlm.nih.gov/pubmed/30372510,http://www.ncbi.nlm.nih.gov/pubmed/25532076 | Is cariprazine effective for treatment of bipolar disorder? | Yes, cariprazine is effective for bipolar disorder. |
http://www.ncbi.nlm.nih.gov/pubmed/25878736,http://www.ncbi.nlm.nih.gov/pubmed/29593205,http://www.ncbi.nlm.nih.gov/pubmed/22886034,http://www.ncbi.nlm.nih.gov/pubmed/24075844,http://www.ncbi.nlm.nih.gov/pubmed/25506155,http://www.ncbi.nlm.nih.gov/pubmed/29303456,http://www.ncbi.nlm.nih.gov/pubmed/7674025 | Is Bobble head doll syndrome associated with hydrocephalus? | Yes, Bobble head doll syndrome is associated with obstructive hydrocephalus. |
http://www.ncbi.nlm.nih.gov/pubmed/21348815 | Can breastfeeding confer protection from type I diabetes? | In the neonate and infant lactation confers protection from future type 1 diabetes. |
http://www.ncbi.nlm.nih.gov/pubmed/28381231 | Can pets affect infant microbiomed? | Yes, exposure to household furry pets influences the gut microbiota of infants. |
http://www.ncbi.nlm.nih.gov/pubmed/29016169 | Is there any association between the human gut microbiome and depression? | Scientific findings are suggestive of the possibility that dysregulation of the enteric microbiota (i.e., dysbiosis) and associated bacterial translocation across the intestinal epithelium may be involved in the pathophysiology of stress-related psychiatric disorders, particularly depression. |
http://www.ncbi.nlm.nih.gov/pubmed/19625390,http://www.ncbi.nlm.nih.gov/pubmed/21079672,http://www.ncbi.nlm.nih.gov/pubmed/17916239,http://www.ncbi.nlm.nih.gov/pubmed/27799339,http://www.ncbi.nlm.nih.gov/pubmed/23300483,http://www.ncbi.nlm.nih.gov/pubmed/20525287 | Are whole-genome duplications more divergent than small-scale duplications in yeast? | Whole-genome duplicates tend to exhibit less profound phenotypic effects when deleted, are functionally less divergent, and are associated with a different set of functions than their small-scale duplicate counterparts. |
http://www.ncbi.nlm.nih.gov/pubmed/26681518,http://www.ncbi.nlm.nih.gov/pubmed/22977178,http://www.ncbi.nlm.nih.gov/pubmed/28090380,http://www.ncbi.nlm.nih.gov/pubmed/26979517 | Do yeast LTR give rise to circular DNA? | A recent study on circular DNAs in yeast found that transposable element sequence residing in circular structures mostly corresponded to full-length transposable elements. Circular retrotransposition products are generated by a LINE retrotransposon. Yeast LTR elements generate circular DNAs through recombination events between their flanking long terminal repeats (LTRs). Circular DNAs can be generated by recombination between LTRs residing at different genomic loci, in which case the circular DNA will contain the intervening sequence. |
http://www.ncbi.nlm.nih.gov/pubmed/30127433 | Is cohesin linked to myeloid differentiation? | Yes. There has been a link found between cohesin and myeloid differentiation which may help explain the prevalence of cohesin mutations in human acute myeloid leukemia. |
http://www.ncbi.nlm.nih.gov/pubmed/28988646 | Is pembrolizumab effective against Ewing's sarcoma? | None of the 13 patients with Ewing's sarcoma receiving pembrolizumab had an objective response. |
http://www.ncbi.nlm.nih.gov/pubmed/28165476 | Can gene therapy restore auditory function? | Yes, gene therapy can restore auditory function. |
http://www.ncbi.nlm.nih.gov/pubmed/30359302 | Is the PINES framework being used for the prediction of coding variants? | No. PINES (Phenotype-Informed Noncoding Element Scoring) predicts the functional impact of noncoding variants by integrating epigenetic annotations in a phenotype-dependent manner. PINES enables analyses to be customized towards genomic annotations from cell types of the highest relevance given the phenotype of interest. |
http://www.ncbi.nlm.nih.gov/pubmed/25886781,http://www.ncbi.nlm.nih.gov/pubmed/25595151 | Is erythropoietin effective for treatment of amyotrophic lateral sclerosis? | No, erythropoietin is not effective for treatment of amyotrophic lateral sclerosis. |
http://www.ncbi.nlm.nih.gov/pubmed/16802291 | Is celecoxib effective for treatment of amyotrophic lateral sclerosis? | No. In clinical trial celecoxib did not have a beneficial effect on research subjects with ALS, and it was safe. A biological effect of celecoxib was not demonstrated in the cerebrospinal fluid. Further studies of celecoxib at a dosage of 800 mg/day in ALS were not recommended. |
http://www.ncbi.nlm.nih.gov/pubmed/23040961,http://www.ncbi.nlm.nih.gov/pubmed/21617906,http://www.ncbi.nlm.nih.gov/pubmed/27879619,http://www.ncbi.nlm.nih.gov/pubmed/23689678,http://www.ncbi.nlm.nih.gov/pubmed/20224466 | What is hemolacria? | Hemolacria is a rare phenomenon of bloody tears caused by various ocular and systemic conditions, as well as psychological, pharmacologic, and idiopathic etiologies. |
http://www.ncbi.nlm.nih.gov/pubmed/29358049 | Are ultraconserved enhancers important for normal development? | Yes, ultraconserved enhancers are required for normal development. |
http://www.ncbi.nlm.nih.gov/pubmed/30486274,http://www.ncbi.nlm.nih.gov/pubmed/28459137,http://www.ncbi.nlm.nih.gov/pubmed/29495404,http://www.ncbi.nlm.nih.gov/pubmed/28415833 | Is chlorotoxin a peptide? | Yes |
http://www.ncbi.nlm.nih.gov/pubmed/29104121 | Does vesatolimod inhibit TLR7? | No, vesatolimod is an agonist of toll-like receptor 7. |
http://www.ncbi.nlm.nih.gov/pubmed/29447106,http://www.ncbi.nlm.nih.gov/pubmed/29323455 | Is selenocysteine an aminoacid? | Yes |
http://www.ncbi.nlm.nih.gov/pubmed/20393639,http://www.ncbi.nlm.nih.gov/pubmed/25480757,http://www.ncbi.nlm.nih.gov/pubmed/23530860,http://www.ncbi.nlm.nih.gov/pubmed/30120738,http://www.ncbi.nlm.nih.gov/pubmed/24100494,http://www.ncbi.nlm.nih.gov/pubmed/29773767,http://www.ncbi.nlm.nih.gov/pubmed/25896687,http://www.ncbi.nlm.nih.gov/pubmed/29982575,http://www.ncbi.nlm.nih.gov/pubmed/29972742 | Is Tecovirimat effective for smallpox? | Yes, tecovirimat FDA approved for treatment of smallpox. |
http://www.ncbi.nlm.nih.gov/pubmed/25827645 | Can simvastatin alleviate depressive symptoms? | Yes, simvastatin decreases depressive symptoms. |