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http://www.ncbi.nlm.nih.gov/pubmed/18030866,http://www.ncbi.nlm.nih.gov/pubmed/21470266,http://www.ncbi.nlm.nih.gov/pubmed/20807443,http://www.ncbi.nlm.nih.gov/pubmed/20861123,http://www.ncbi.nlm.nih.gov/pubmed/28964455,http://www.ncbi.nlm.nih.gov/pubmed/21920547,http://www.ncbi.nlm.nih.gov/pubmed/21737172,http://www.ncbi.nlm.nih.gov/pubmed/22027330,http://www.ncbi.nlm.nih.gov/pubmed/27522349,http://www.ncbi.nlm.nih.gov/pubmed/27737895,http://www.ncbi.nlm.nih.gov/pubmed/20923490,http://www.ncbi.nlm.nih.gov/pubmed/26630892,http://www.ncbi.nlm.nih.gov/pubmed/24511995,http://www.ncbi.nlm.nih.gov/pubmed/15644138 | What does A1C measure? | Glycated proteins, such as glycated hemoglobin (HbA1c) or glycated albumin (GA) in the blood, are essential indicators of glycemic control for diabetes mellitus. The A1C measures the amount of glycated hemoglobin in the blood and is a marker for control of blood glucose. Poor glucose control is indicative of diabetes mellitus. |
http://www.ncbi.nlm.nih.gov/pubmed/26391045,http://www.ncbi.nlm.nih.gov/pubmed/19636252,http://www.ncbi.nlm.nih.gov/pubmed/26243569,http://www.ncbi.nlm.nih.gov/pubmed/9800738,http://www.ncbi.nlm.nih.gov/pubmed/27245382,http://www.ncbi.nlm.nih.gov/pubmed/2143053,http://www.ncbi.nlm.nih.gov/pubmed/3036686,http://www.ncbi.nlm.nih.gov/pubmed/9050924,http://www.ncbi.nlm.nih.gov/pubmed/23394617,http://www.ncbi.nlm.nih.gov/pubmed/18801168,http://www.ncbi.nlm.nih.gov/pubmed/27931082,http://www.ncbi.nlm.nih.gov/pubmed/11371509,http://www.ncbi.nlm.nih.gov/pubmed/26300975,http://www.ncbi.nlm.nih.gov/pubmed/18056702,http://www.ncbi.nlm.nih.gov/pubmed/21081842,http://www.ncbi.nlm.nih.gov/pubmed/19212162,http://www.ncbi.nlm.nih.gov/pubmed/25862935,http://www.ncbi.nlm.nih.gov/pubmed/24980541,http://www.ncbi.nlm.nih.gov/pubmed/2880544,http://www.ncbi.nlm.nih.gov/pubmed/15176487,http://www.ncbi.nlm.nih.gov/pubmed/25706610,http://www.ncbi.nlm.nih.gov/pubmed/25738006,http://www.ncbi.nlm.nih.gov/pubmed/23686780,http://www.ncbi.nlm.nih.gov/pubmed/28342823,http://www.ncbi.nlm.nih.gov/pubmed/24210986,http://www.ncbi.nlm.nih.gov/pubmed/7532356 | Down's syndrome occurs when an individual has an extra copy or part of a copy of chromosome 21, yes or no? | Yes, Downs syndrome is caused by a duplication or all or part of chromosome 21.Down syndrome (DS), trisomy 21, is caused by increased dose of genes present on human chromosome 21 (HSA21). Down syndrome (DS; trisomy 21) is the most common survivable disorder due to aneuploidy. |
http://www.ncbi.nlm.nih.gov/pubmed/17980312,http://www.ncbi.nlm.nih.gov/pubmed/22939693,http://www.ncbi.nlm.nih.gov/pubmed/27622416,http://www.ncbi.nlm.nih.gov/pubmed/28060197,http://www.ncbi.nlm.nih.gov/pubmed/22038757,http://www.ncbi.nlm.nih.gov/pubmed/29093661,http://www.ncbi.nlm.nih.gov/pubmed/26910679,http://www.ncbi.nlm.nih.gov/pubmed/27226847,http://www.ncbi.nlm.nih.gov/pubmed/24082921,http://www.ncbi.nlm.nih.gov/pubmed/21811467,http://www.ncbi.nlm.nih.gov/pubmed/18344207,http://www.ncbi.nlm.nih.gov/pubmed/18326400,http://www.ncbi.nlm.nih.gov/pubmed/27481450,http://www.ncbi.nlm.nih.gov/pubmed/7884500,http://www.ncbi.nlm.nih.gov/pubmed/14753738,http://www.ncbi.nlm.nih.gov/pubmed/23249483,http://www.ncbi.nlm.nih.gov/pubmed/20108486 | What is craniosynostosis? | Craniosynostosis is a result of premature fusion of cranial sutures, leading to alterations of the pattern of cranial growth, resulting in abnormal shape of the head and dysmorphic facial features. |
http://www.ncbi.nlm.nih.gov/pubmed/29070071 | Which method has been developed for assignment of enhancers to target genes? | While genomic assays can identify putative enhancers en masse, assigning target genes is a complex challenge. McEnhancer is a machine learning approach, which links target genes to putative enhancers via a semi-supervised learning algorithm that predicts gene expression patterns based on enriched sequence features. Predicted expression patterns were 73-98% accurate, predicted assignments showed strong Hi-C interaction enrichment, enhancer-associated histone modifications were evident, and known functional motifs were recovered. |
http://www.ncbi.nlm.nih.gov/pubmed/28366801 | Describe Click-PEGylation | One approach that can facilitate a targeted assessment of candidate proteins, as well as proteins that are low in abundance or proteomically challenging, is by electrophoretic mobility shift assays. Redox-modified cysteine residues are selectively tagged with a large group, such as a polyethylene glycol (PEG) polymer, and then the proteins are separated by electrophoresis followed by immunoblotting, which allows the inference of redox changes based on band shifts. However, the applicability of this method has been impaired by the difficulty of cleanly modifying protein thiols by large PEG reagents. To establish a more robust method for redox-selective PEGylation a Click chemistry approach has been developed where free thiol groups are first labelled with a reagent modified to contain an alkyne moiety, which is subsequently Click-reacted with a PEG molecule containing a complementary azide function. This strategy can be adapted to study reversibly reduced or oxidised cysteines. Separation of the thiol labelling step from the PEG conjugation greatly facilitates the fidelity and flexibility of this approach. |
http://www.ncbi.nlm.nih.gov/pubmed/22516994,http://www.ncbi.nlm.nih.gov/pubmed/27795838,http://www.ncbi.nlm.nih.gov/pubmed/23172751,http://www.ncbi.nlm.nih.gov/pubmed/17477466,http://www.ncbi.nlm.nih.gov/pubmed/28116652,http://www.ncbi.nlm.nih.gov/pubmed/28123902,http://www.ncbi.nlm.nih.gov/pubmed/25861457,http://www.ncbi.nlm.nih.gov/pubmed/10685800,http://www.ncbi.nlm.nih.gov/pubmed/16761499,http://www.ncbi.nlm.nih.gov/pubmed/10955328,http://www.ncbi.nlm.nih.gov/pubmed/19762400,http://www.ncbi.nlm.nih.gov/pubmed/11480850,http://www.ncbi.nlm.nih.gov/pubmed/15468356,http://www.ncbi.nlm.nih.gov/pubmed/8235662,http://www.ncbi.nlm.nih.gov/pubmed/27365721,http://www.ncbi.nlm.nih.gov/pubmed/2195948,http://www.ncbi.nlm.nih.gov/pubmed/16681575,http://www.ncbi.nlm.nih.gov/pubmed/12007552,http://www.ncbi.nlm.nih.gov/pubmed/28243944,http://www.ncbi.nlm.nih.gov/pubmed/16354890,http://www.ncbi.nlm.nih.gov/pubmed/16150398,http://www.ncbi.nlm.nih.gov/pubmed/12945718,http://www.ncbi.nlm.nih.gov/pubmed/24705033,http://www.ncbi.nlm.nih.gov/pubmed/7993706 | A SLEDAI score is associated with Systemic Lupus Erythematosus. What is a SLEDAI score? | Disease activity of Systemic Lupus Erythematosis was evaluated according to the SLE Disease Activity Index (SLEDAI) score which score disease activity based on a number of parameters.A complete Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score was obtained for each patient.Disease activity of SLE was evaluated according to the SLE Disease Activity Index (SLEDAI) score. |
http://www.ncbi.nlm.nih.gov/pubmed/28007627,http://www.ncbi.nlm.nih.gov/pubmed/25870797,http://www.ncbi.nlm.nih.gov/pubmed/27836576,http://www.ncbi.nlm.nih.gov/pubmed/21213368,http://www.ncbi.nlm.nih.gov/pubmed/26503946,http://www.ncbi.nlm.nih.gov/pubmed/27179218,http://www.ncbi.nlm.nih.gov/pubmed/27468968,http://www.ncbi.nlm.nih.gov/pubmed/22084642,http://www.ncbi.nlm.nih.gov/pubmed/11561161,http://www.ncbi.nlm.nih.gov/pubmed/25407901,http://www.ncbi.nlm.nih.gov/pubmed/27573755,http://www.ncbi.nlm.nih.gov/pubmed/26811689,http://www.ncbi.nlm.nih.gov/pubmed/25727400,http://www.ncbi.nlm.nih.gov/pubmed/27892978,http://www.ncbi.nlm.nih.gov/pubmed/21613408,http://www.ncbi.nlm.nih.gov/pubmed/22184391,http://www.ncbi.nlm.nih.gov/pubmed/23104988,http://www.ncbi.nlm.nih.gov/pubmed/22681779,http://www.ncbi.nlm.nih.gov/pubmed/21205076,http://www.ncbi.nlm.nih.gov/pubmed/26395848,http://www.ncbi.nlm.nih.gov/pubmed/21829174,http://www.ncbi.nlm.nih.gov/pubmed/18923525,http://www.ncbi.nlm.nih.gov/pubmed/20961208,http://www.ncbi.nlm.nih.gov/pubmed/25351247,http://www.ncbi.nlm.nih.gov/pubmed/17611412,http://www.ncbi.nlm.nih.gov/pubmed/18070884,http://www.ncbi.nlm.nih.gov/pubmed/27217763,http://www.ncbi.nlm.nih.gov/pubmed/26294238,http://www.ncbi.nlm.nih.gov/pubmed/27899405,http://www.ncbi.nlm.nih.gov/pubmed/20979469,http://www.ncbi.nlm.nih.gov/pubmed/25979929,http://www.ncbi.nlm.nih.gov/pubmed/23499906,http://www.ncbi.nlm.nih.gov/pubmed/25759656,http://www.ncbi.nlm.nih.gov/pubmed/27646667,http://www.ncbi.nlm.nih.gov/pubmed/25601484,http://www.ncbi.nlm.nih.gov/pubmed/26076736,http://www.ncbi.nlm.nih.gov/pubmed/21288922,http://www.ncbi.nlm.nih.gov/pubmed/22998583 | What disease is the ALK tyrosine kinase associated with? | The anaplastic lymphoma kinase (ALK) gene encodes a receptor tyrosine kinase, and many kinds of ALK fusion genes have been found in a variety of carcinomas |
http://www.ncbi.nlm.nih.gov/pubmed/26874956,http://www.ncbi.nlm.nih.gov/pubmed/20920140,http://www.ncbi.nlm.nih.gov/pubmed/16928720,http://www.ncbi.nlm.nih.gov/pubmed/29161297,http://www.ncbi.nlm.nih.gov/pubmed/21539743,http://www.ncbi.nlm.nih.gov/pubmed/24931899,http://www.ncbi.nlm.nih.gov/pubmed/28681972,http://www.ncbi.nlm.nih.gov/pubmed/28678546,http://www.ncbi.nlm.nih.gov/pubmed/26237261 | CURB65 score is used for stratification of which disease? | CURB65 (confusion, urea, respiration, blood pressure; age>65 years) is used for assessment of pneumonia severity. |
http://www.ncbi.nlm.nih.gov/pubmed/27710791 | Which resource has been developed in order to study the transcriptional regulation of GABAergic cell fate? | Subpallial Enhancer Transgenic Lines is a data and tool resource to study transcriptional regulation of GABAergic cell fate. |
http://www.ncbi.nlm.nih.gov/pubmed/27480755,http://www.ncbi.nlm.nih.gov/pubmed/28856226,http://www.ncbi.nlm.nih.gov/pubmed/27779785,http://www.ncbi.nlm.nih.gov/pubmed/28510807,http://www.ncbi.nlm.nih.gov/pubmed/29055930,http://www.ncbi.nlm.nih.gov/pubmed/23293714,http://www.ncbi.nlm.nih.gov/pubmed/27842889,http://www.ncbi.nlm.nih.gov/pubmed/22178107,http://www.ncbi.nlm.nih.gov/pubmed/15482344,http://www.ncbi.nlm.nih.gov/pubmed/28198820,http://www.ncbi.nlm.nih.gov/pubmed/29171941,http://www.ncbi.nlm.nih.gov/pubmed/23403770 | Is creatinine assessment included in the MELD score? | Yes, creatinine is included in the Model For End-Stage Liver Disease (MELD) score. Other components of the MELD score are international normalized ratio and serum billirubin. The MELD score is used for evaluation of liver cirrhosis. |
http://www.ncbi.nlm.nih.gov/pubmed/28264928,http://www.ncbi.nlm.nih.gov/pubmed/28438613,http://www.ncbi.nlm.nih.gov/pubmed/28269788,http://www.ncbi.nlm.nih.gov/pubmed/28933272,http://www.ncbi.nlm.nih.gov/pubmed/27422357,http://www.ncbi.nlm.nih.gov/pubmed/28987163,http://www.ncbi.nlm.nih.gov/pubmed/28205585 | List the two most important synaptic markers. | postsynaptic density 95
synaptophysinSynaptic markers include acetylcholine, gamma-aminobutyric acid (GABA), glutamine, glycine and synaptophysin. |
http://www.ncbi.nlm.nih.gov/pubmed/26704594,http://www.ncbi.nlm.nih.gov/pubmed/28372959,http://www.ncbi.nlm.nih.gov/pubmed/15500393,http://www.ncbi.nlm.nih.gov/pubmed/28131133,http://www.ncbi.nlm.nih.gov/pubmed/16951470,http://www.ncbi.nlm.nih.gov/pubmed/10819845,http://www.ncbi.nlm.nih.gov/pubmed/24373794,http://www.ncbi.nlm.nih.gov/pubmed/24930824,http://www.ncbi.nlm.nih.gov/pubmed/18824103,http://www.ncbi.nlm.nih.gov/pubmed/16451049,http://www.ncbi.nlm.nih.gov/pubmed/16081843,http://www.ncbi.nlm.nih.gov/pubmed/28978566,http://www.ncbi.nlm.nih.gov/pubmed/28978567,http://www.ncbi.nlm.nih.gov/pubmed/25466304,http://www.ncbi.nlm.nih.gov/pubmed/14505351,http://www.ncbi.nlm.nih.gov/pubmed/27240168,http://www.ncbi.nlm.nih.gov/pubmed/16951478,http://www.ncbi.nlm.nih.gov/pubmed/16972673,http://www.ncbi.nlm.nih.gov/pubmed/27048997,http://www.ncbi.nlm.nih.gov/pubmed/23925896,http://www.ncbi.nlm.nih.gov/pubmed/15864926,http://www.ncbi.nlm.nih.gov/pubmed/14645673,http://www.ncbi.nlm.nih.gov/pubmed/20169039,http://www.ncbi.nlm.nih.gov/pubmed/25236805,http://www.ncbi.nlm.nih.gov/pubmed/28185712,http://www.ncbi.nlm.nih.gov/pubmed/12036407,http://www.ncbi.nlm.nih.gov/pubmed/19382614,http://www.ncbi.nlm.nih.gov/pubmed/20303261,http://www.ncbi.nlm.nih.gov/pubmed/11795362,http://www.ncbi.nlm.nih.gov/pubmed/12650712,http://www.ncbi.nlm.nih.gov/pubmed/18279543,http://www.ncbi.nlm.nih.gov/pubmed/11046073,http://www.ncbi.nlm.nih.gov/pubmed/10629380,http://www.ncbi.nlm.nih.gov/pubmed/22570330,http://www.ncbi.nlm.nih.gov/pubmed/28098599,http://www.ncbi.nlm.nih.gov/pubmed/20485909,http://www.ncbi.nlm.nih.gov/pubmed/27585851,http://www.ncbi.nlm.nih.gov/pubmed/28030966,http://www.ncbi.nlm.nih.gov/pubmed/24410282,http://www.ncbi.nlm.nih.gov/pubmed/11421557,http://www.ncbi.nlm.nih.gov/pubmed/12373918,http://www.ncbi.nlm.nih.gov/pubmed/18044180,http://www.ncbi.nlm.nih.gov/pubmed/17504144,http://www.ncbi.nlm.nih.gov/pubmed/10769110,http://www.ncbi.nlm.nih.gov/pubmed/26343247,http://www.ncbi.nlm.nih.gov/pubmed/20446043,http://www.ncbi.nlm.nih.gov/pubmed/23062036,http://www.ncbi.nlm.nih.gov/pubmed/17448265,http://www.ncbi.nlm.nih.gov/pubmed/16263696,http://www.ncbi.nlm.nih.gov/pubmed/18637493,http://www.ncbi.nlm.nih.gov/pubmed/24667357 | What is a SERM? | A SERM is a Selective Estrogen Receptor Modulator.selective estrogen receptor modulator (SERM),elective estrogen receptor modulator (SERM),elective estrogen receptor modulator (SERM),. |
http://www.ncbi.nlm.nih.gov/pubmed/18793760,http://www.ncbi.nlm.nih.gov/pubmed/26883352,http://www.ncbi.nlm.nih.gov/pubmed/14747475,http://www.ncbi.nlm.nih.gov/pubmed/20300628,http://www.ncbi.nlm.nih.gov/pubmed/27613408,http://www.ncbi.nlm.nih.gov/pubmed/27130174 | Is celiac disease caused by gliadin-induced transglutaminase-2 (TG2)-dependent events ? | Celiac disease is caused by gliadin-induced transglutaminase-2 (TG2)-dependent events following ingestion of dietary gluten. |
http://www.ncbi.nlm.nih.gov/pubmed/28827824 | Which resource contains accurate enhancer predictions in the developing limb? | Limb-Enhancer Genie (LEG) is a collection of highly accurate, genome-wide predictions of enhancers in the developing limb, available through a user-friendly online interface. Limb enhancers are predicted using a combination of >50 published limb-specific datasets and clusters of evolutionarily conserved transcription factor binding sites, taking advantage of the patterns observed at previously in vivo validated elements. |
http://www.ncbi.nlm.nih.gov/pubmed/28696638,http://www.ncbi.nlm.nih.gov/pubmed/27817209,http://www.ncbi.nlm.nih.gov/pubmed/26419478,http://www.ncbi.nlm.nih.gov/pubmed/16536004,http://www.ncbi.nlm.nih.gov/pubmed/10719453,http://www.ncbi.nlm.nih.gov/pubmed/17081481,http://www.ncbi.nlm.nih.gov/pubmed/27421131,http://www.ncbi.nlm.nih.gov/pubmed/26204816,http://www.ncbi.nlm.nih.gov/pubmed/10598414,http://www.ncbi.nlm.nih.gov/pubmed/28056473,http://www.ncbi.nlm.nih.gov/pubmed/28474323,http://www.ncbi.nlm.nih.gov/pubmed/23884295,http://www.ncbi.nlm.nih.gov/pubmed/23880702,http://www.ncbi.nlm.nih.gov/pubmed/24753153,http://www.ncbi.nlm.nih.gov/pubmed/29137908,http://www.ncbi.nlm.nih.gov/pubmed/23538719 | What is the first line treatment for sarcoidosis? | Sarcoidosis is a systemic granulomatous disease that affects numerous organs, commonly manifesting at the lungs and skin. Corticosteroids remain the first line of treatment. |
http://www.ncbi.nlm.nih.gov/pubmed/28119507,http://www.ncbi.nlm.nih.gov/pubmed/20579633,http://www.ncbi.nlm.nih.gov/pubmed/27399588,http://www.ncbi.nlm.nih.gov/pubmed/27897326,http://www.ncbi.nlm.nih.gov/pubmed/14608551,http://www.ncbi.nlm.nih.gov/pubmed/27642799,http://www.ncbi.nlm.nih.gov/pubmed/18186120,http://www.ncbi.nlm.nih.gov/pubmed/22751905,http://www.ncbi.nlm.nih.gov/pubmed/9064551,http://www.ncbi.nlm.nih.gov/pubmed/7977884,http://www.ncbi.nlm.nih.gov/pubmed/9603574,http://www.ncbi.nlm.nih.gov/pubmed/17496179,http://www.ncbi.nlm.nih.gov/pubmed/27481266,http://www.ncbi.nlm.nih.gov/pubmed/28555557,http://www.ncbi.nlm.nih.gov/pubmed/21114345,http://www.ncbi.nlm.nih.gov/pubmed/27959459,http://www.ncbi.nlm.nih.gov/pubmed/19755574,http://www.ncbi.nlm.nih.gov/pubmed/27091455 | Which personality disorder is treated using dialectical behavior therapy? | Dialectical behavior therapy is an evidence-based psychosocial treatment with efficacy in reducing self-harm behaviors in borderline personality disorder. |
http://www.ncbi.nlm.nih.gov/pubmed/22918592,http://www.ncbi.nlm.nih.gov/pubmed/227871,http://www.ncbi.nlm.nih.gov/pubmed/12861020,http://www.ncbi.nlm.nih.gov/pubmed/19000038,http://www.ncbi.nlm.nih.gov/pubmed/24035200,http://www.ncbi.nlm.nih.gov/pubmed/9580686,http://www.ncbi.nlm.nih.gov/pubmed/21441898,http://www.ncbi.nlm.nih.gov/pubmed/12806117,http://www.ncbi.nlm.nih.gov/pubmed/21278448,http://www.ncbi.nlm.nih.gov/pubmed/27989437,http://www.ncbi.nlm.nih.gov/pubmed/14693726,http://www.ncbi.nlm.nih.gov/pubmed/25814667,http://www.ncbi.nlm.nih.gov/pubmed/20131965,http://www.ncbi.nlm.nih.gov/pubmed/26175049,http://www.ncbi.nlm.nih.gov/pubmed/28301743,http://www.ncbi.nlm.nih.gov/pubmed/20178844,http://www.ncbi.nlm.nih.gov/pubmed/11710514,http://www.ncbi.nlm.nih.gov/pubmed/22419157,http://www.ncbi.nlm.nih.gov/pubmed/23792162,http://www.ncbi.nlm.nih.gov/pubmed/28159842,http://www.ncbi.nlm.nih.gov/pubmed/25916711,http://www.ncbi.nlm.nih.gov/pubmed/28496054,http://www.ncbi.nlm.nih.gov/pubmed/12228807,http://www.ncbi.nlm.nih.gov/pubmed/14690413 | What cellular process are okazaki fragments associated with? | Okazaki fragments are involved in DNA replication |
http://www.ncbi.nlm.nih.gov/pubmed/29146257,http://www.ncbi.nlm.nih.gov/pubmed/10984842,http://www.ncbi.nlm.nih.gov/pubmed/27079356,http://www.ncbi.nlm.nih.gov/pubmed/11908651,http://www.ncbi.nlm.nih.gov/pubmed/11536867,http://www.ncbi.nlm.nih.gov/pubmed/20658121,http://www.ncbi.nlm.nih.gov/pubmed/26618715,http://www.ncbi.nlm.nih.gov/pubmed/28132155,http://www.ncbi.nlm.nih.gov/pubmed/28132141,http://www.ncbi.nlm.nih.gov/pubmed/24226111 | Does wheat belongs to the genus Avena, yes or no? | oat seedlings (Avena sativa)Wheat belongs to the species Triticum not to the genus Avena.oat seedlings (Avena sativa). |
http://www.ncbi.nlm.nih.gov/pubmed/11025268,http://www.ncbi.nlm.nih.gov/pubmed/18459549,http://www.ncbi.nlm.nih.gov/pubmed/10948822,http://www.ncbi.nlm.nih.gov/pubmed/20006195,http://www.ncbi.nlm.nih.gov/pubmed/11845812,http://www.ncbi.nlm.nih.gov/pubmed/22555524,http://www.ncbi.nlm.nih.gov/pubmed/20949462 | Clue cells are characteristics to which causative bacteria of vaginitis? | Clue cells are characteristic to Gardnerella vaginalis vaginitis (bacterial vaginosis). Depopulation of lactobacilli from the normal vaginal flora and overgrowth of Gardnerella vaginalis and other anaerobic species are the presumed etiology. The diagnosis is confirmed when at least three of the following four findings are present (Amsel's criteria): 1) thin, homogenous discharge, 2) pH greater than 4.5, 3) positive amine test, and 4) presence of clue cell. |
http://www.ncbi.nlm.nih.gov/pubmed/27272704,http://www.ncbi.nlm.nih.gov/pubmed/28501753,http://www.ncbi.nlm.nih.gov/pubmed/28872273,http://www.ncbi.nlm.nih.gov/pubmed/28872274,http://www.ncbi.nlm.nih.gov/pubmed/24856744,http://www.ncbi.nlm.nih.gov/pubmed/26936099,http://www.ncbi.nlm.nih.gov/pubmed/28710996,http://www.ncbi.nlm.nih.gov/pubmed/11595590,http://www.ncbi.nlm.nih.gov/pubmed/28846743,http://www.ncbi.nlm.nih.gov/pubmed/28931369,http://www.ncbi.nlm.nih.gov/pubmed/28273857 | What is included in the fourth generation HIV test? | Fourth generation assays detect simultaneously antibodies for HIV and the p24 antigen. It identifies HIV infection earlier than previous generation tests. |
http://www.ncbi.nlm.nih.gov/pubmed/26645452,http://www.ncbi.nlm.nih.gov/pubmed/19939537,http://www.ncbi.nlm.nih.gov/pubmed/19588376,http://www.ncbi.nlm.nih.gov/pubmed/12723309,http://www.ncbi.nlm.nih.gov/pubmed/17059194,http://www.ncbi.nlm.nih.gov/pubmed/23340762,http://www.ncbi.nlm.nih.gov/pubmed/15680568,http://www.ncbi.nlm.nih.gov/pubmed/24139754,http://www.ncbi.nlm.nih.gov/pubmed/18956185 | Which disease is diagnosed using the Finkelstein's test? | Finkelstein's test is the classic diagnostic test for de Quervain's disease. |
http://www.ncbi.nlm.nih.gov/pubmed/28941722 | For which type of cancer can uc.189 be used as a potential prognostic biomarker? | ESCCHigh expression of uc.189 might reflect poor prognosis of Esophageal squamous cell carcinomas (ESCC) and indicate a potential diagnostic target in ESCC patients. Uc.189 might be considered as a novel molecule involved in ESCC progression, which provides a potential prognostic biomarker and therapeutic target.Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of uc.189 in matched cancerous tissues and adjacent noncancerous tissues from 152 patients with ESCC. Uc.189 might be considered as a novel molecule involved in ESCC progression, which provides a potential prognostic biomarker and therapeutic target. |
http://www.ncbi.nlm.nih.gov/pubmed/28382457,http://www.ncbi.nlm.nih.gov/pubmed/20802525 | Does Uc.160 promote cancer? | No. Uc.160+ is a T-UCR reported to be downregulated in human cancer. In addition, Uc.160+ could possibly have a tumor suppressive role in gastric cancer. |
http://www.ncbi.nlm.nih.gov/pubmed/6453959,http://www.ncbi.nlm.nih.gov/pubmed/8803434,http://www.ncbi.nlm.nih.gov/pubmed/8199664,http://www.ncbi.nlm.nih.gov/pubmed/8456342 | What causes Black Lung? | Black lung, also known as pneumoconiosis, is caused by chronic exposure to coal dust. |
http://www.ncbi.nlm.nih.gov/pubmed/25516950,http://www.ncbi.nlm.nih.gov/pubmed/18316452,http://www.ncbi.nlm.nih.gov/pubmed/21625670,http://www.ncbi.nlm.nih.gov/pubmed/22438579,http://www.ncbi.nlm.nih.gov/pubmed/25028113,http://www.ncbi.nlm.nih.gov/pubmed/21937467,http://www.ncbi.nlm.nih.gov/pubmed/10402417,http://www.ncbi.nlm.nih.gov/pubmed/23975951,http://www.ncbi.nlm.nih.gov/pubmed/24720355,http://www.ncbi.nlm.nih.gov/pubmed/26793677,http://www.ncbi.nlm.nih.gov/pubmed/22606995,http://www.ncbi.nlm.nih.gov/pubmed/17526683,http://www.ncbi.nlm.nih.gov/pubmed/18552646,http://www.ncbi.nlm.nih.gov/pubmed/28601921 | List four principles of medical ethics. | The four principles of medical ethics proposed by Beauchamp and Childress are autonomy, non-maleficence, beneficence and justice. They have been extremely influential in the field of medical ethics, and are fundamental for understanding the current approach to ethical assessment in health care. |
http://www.ncbi.nlm.nih.gov/pubmed/29028898 | Which package in Bioconductor has been developed with the aim to analyze differential DNA loops from sequencing data? | Diffloop is an R/Bioconductor package that provides a suite of functions for the quality control, statistical testing, annotation, and visualization of DNA loops.diffloop |
http://www.ncbi.nlm.nih.gov/pubmed/28440774,http://www.ncbi.nlm.nih.gov/pubmed/20622159,http://www.ncbi.nlm.nih.gov/pubmed/27369321,http://www.ncbi.nlm.nih.gov/pubmed/17259493,http://www.ncbi.nlm.nih.gov/pubmed/26804367,http://www.ncbi.nlm.nih.gov/pubmed/18285592,http://www.ncbi.nlm.nih.gov/pubmed/21219428,http://www.ncbi.nlm.nih.gov/pubmed/26009740,http://www.ncbi.nlm.nih.gov/pubmed/24857262,http://www.ncbi.nlm.nih.gov/pubmed/23001730 | Which disease can be diagnosed with the "probe to bone" test? | Probe-to-bone test is used for the diagnosis of diabetic foot osteomyelitis. The test has good sensitivity and specificity. Other diagnostic tests of diabetic foot osteomyelitis are plain films and magnetic resonance imaging. |
http://www.ncbi.nlm.nih.gov/pubmed/26816569,http://www.ncbi.nlm.nih.gov/pubmed/17315050,http://www.ncbi.nlm.nih.gov/pubmed/17160610,http://www.ncbi.nlm.nih.gov/pubmed/28291967,http://www.ncbi.nlm.nih.gov/pubmed/29083100,http://www.ncbi.nlm.nih.gov/pubmed/10233667,http://www.ncbi.nlm.nih.gov/pubmed/15262663,http://www.ncbi.nlm.nih.gov/pubmed/23182067,http://www.ncbi.nlm.nih.gov/pubmed/26299894,http://www.ncbi.nlm.nih.gov/pubmed/26189561 | Can doxycycline cause photosensitivity? | Yes, one of the most important dermatologic side effects of doxycycline is photosensitivity. Clinical symptoms vary from light sunburn-like sensation (burning, erythema) to large-area photodermatitis. |
http://www.ncbi.nlm.nih.gov/pubmed/28791347,http://www.ncbi.nlm.nih.gov/pubmed/15986406,http://www.ncbi.nlm.nih.gov/pubmed/28132828,http://www.ncbi.nlm.nih.gov/pubmed/28132825,http://www.ncbi.nlm.nih.gov/pubmed/16943315,http://www.ncbi.nlm.nih.gov/pubmed/25583290 | What body process does the Dentate Gyrus Mossy Cell control? | Dentate gyrus mossy cells control spontaneous convulsive seizures and cognition |
http://www.ncbi.nlm.nih.gov/pubmed/3425783,http://www.ncbi.nlm.nih.gov/pubmed/20306414,http://www.ncbi.nlm.nih.gov/pubmed/10623985 | Which ligament is most commonly injured in dashboard injury? | Posterior cruciate ligament injuries have a reported incidence of between 3 and 37%, depending on the clinical setting. The most common mechanism of injury in motor vehicle accidents is a dashboard injury or direct force to the proximal anterior tibia. |
http://www.ncbi.nlm.nih.gov/pubmed/25854787,http://www.ncbi.nlm.nih.gov/pubmed/28992906 | What is the normal body temperature in dogs? | According to the American Kennel Club (AKC), a temperature of 101 to 102.5 degrees Fahrenheit (38.3 to 39.2 degrees Celsius) is typical for dogs |
http://www.ncbi.nlm.nih.gov/pubmed/26885424,http://www.ncbi.nlm.nih.gov/pubmed/12835855,http://www.ncbi.nlm.nih.gov/pubmed/2307892,http://www.ncbi.nlm.nih.gov/pubmed/18454397,http://www.ncbi.nlm.nih.gov/pubmed/15630597,http://www.ncbi.nlm.nih.gov/pubmed/20184241,http://www.ncbi.nlm.nih.gov/pubmed/21565911,http://www.ncbi.nlm.nih.gov/pubmed/22565854,http://www.ncbi.nlm.nih.gov/pubmed/12233082,http://www.ncbi.nlm.nih.gov/pubmed/24082416,http://www.ncbi.nlm.nih.gov/pubmed/25685372,http://www.ncbi.nlm.nih.gov/pubmed/28079852,http://www.ncbi.nlm.nih.gov/pubmed/17637529,http://www.ncbi.nlm.nih.gov/pubmed/27549672,http://www.ncbi.nlm.nih.gov/pubmed/23917502,http://www.ncbi.nlm.nih.gov/pubmed/25087562,http://www.ncbi.nlm.nih.gov/pubmed/23629431 | List symptoms of Heerfordt syndrome. | Heerfordt syndrome (also known as Heerfordt-Waldenström or uveoparotid fever) is a rare presentation of sarcoidosis characterized by the presence of parotid gland enlargement, facial palsy, anterior uveitis, and fever. |
http://www.ncbi.nlm.nih.gov/pubmed/26260666 | In quadruped mammals, what bones make up the stifle? | In quadruped mammals, the stifle is composed of 3 bones, the femur, the tibia and the patella. |
http://www.ncbi.nlm.nih.gov/pubmed/28667373,http://www.ncbi.nlm.nih.gov/pubmed/18493055,http://www.ncbi.nlm.nih.gov/pubmed/20621981,http://www.ncbi.nlm.nih.gov/pubmed/27634932,http://www.ncbi.nlm.nih.gov/pubmed/16860306,http://www.ncbi.nlm.nih.gov/pubmed/20482863 | Are paralog genes co-regulated? | Paralog genes arise from gene duplication events during evolution, which often lead to similar proteins that cooperate in common pathways and in protein complexes. Consequently, paralogs show correlation in gene expression.Co-regulation of paralog genes in the three-dimensional chromatin architecture. This enables concerted expression of paralogs over diverse cell-types and indicate evolutionary constraints in functional genome organization.Co-regulation of paralog genes in the three-dimensional chromatin architecture. Consequently, paralogs show correlation in gene expression whereby the mechanisms of co-regulation remain unclear.Co-regulation of paralog genes in the three-dimensional chromatin architecture. Consequently, paralogs show correlation in gene expression whereby the mechanisms of co-regulation remain unclear. In eukaryotes, genes are regulated in part by distal enhancer elements through looping interactions with gene promoters.Yes. Paralogs share common regulatory mechanisms and cluster not only in the linear genome but also in the three-dimensional chromatin architecture. This enables concerted expression of paralogs over diverse cell-types and indicate evolutionary constraints in functional genome organization.yesCo-regulation of paralog genes in the three-dimensional chromatin architecture. In eukaryotes, genes are regulated in part by distal enhancer elements through looping interactions with gene promoters. |
http://www.ncbi.nlm.nih.gov/pubmed/28035201,http://www.ncbi.nlm.nih.gov/pubmed/17547856,http://www.ncbi.nlm.nih.gov/pubmed/26395529,http://www.ncbi.nlm.nih.gov/pubmed/28597827,http://www.ncbi.nlm.nih.gov/pubmed/28254463,http://www.ncbi.nlm.nih.gov/pubmed/17129819,http://www.ncbi.nlm.nih.gov/pubmed/25139379 | List 2 approved drug treatments for Inflammatory Bowel Disease (IBD). | Patients with IBD, inflammtory Bowel Disease can be treated with steroids, or 2 approved biosimilar drugs infliximab (IFX) or adalimumab (ADA) |
http://www.ncbi.nlm.nih.gov/pubmed/27366148 | Which tool exists for microsatellite (SSR) loci detection and primer design? | Microsatellites are genomic sequences comprised of tandem repeats of short nucleotide motifs widely used as molecular markers in population genetics. FullSSR is a new bioinformatic tool for microsatellite (SSR) loci detection and primer design using genomic data from NGS assay.FullSSR is a new bioinformatic tool for microsatellite (SSR) loci detection and primer design using genomic data from NGS assay. |
http://www.ncbi.nlm.nih.gov/pubmed/24253304,http://www.ncbi.nlm.nih.gov/pubmed/27789702,http://www.ncbi.nlm.nih.gov/pubmed/29069466,http://www.ncbi.nlm.nih.gov/pubmed/22495751 | Name curated data resources for ChIP-seq data | The MGA repository, Cistrome Data Browser and CR Cistrome are curated data resources for ChIP-seq data. |
http://www.ncbi.nlm.nih.gov/pubmed/29090661,http://www.ncbi.nlm.nih.gov/pubmed/28902580 | Treatment of which disease was studied in the Gore REDUCE Clinical Study? | The Gore REDUCE Clinical Study studied superiority of patent foramen ovale closure in conjunction with antiplatelet therapy over antiplatelet therapy alone in reducing the risk of recurrent clinical ischemic stroke or new silent brain infarct in patients who have had a cryptogenic stroke. |
http://www.ncbi.nlm.nih.gov/pubmed/29028265 | Which comparisons demonstrate the applicability of StereoGene in regulatory genomics? | StereoGene rapidly estimates genome-wide correlation among pairs of genomic features. These features may represent high-throughput data mapped to reference genome or sets of genomic annotations in that reference genome. StereoGene enables correlation of continuous data directly, avoiding the data binarization and subsequent data loss. Correlations are computed among neighboring genomic positions using kernel correlation. Representing the correlation as a function of the genome position, StereoGene outputs the local correlation track as part of the analysis. StereoGene also accounts for confounders such as input DNA by partial correlation. Numerous comparisons of ChIP-Seq datasets from the Human Epigenome Atlas and FANTOM CAGE demonstrate the wide applicability of StereoGene in regulatory genomics. |
http://www.ncbi.nlm.nih.gov/pubmed/28905911 | What is the aim of the 4D nucleome project? | The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions.The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions.The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions.Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. |
http://www.ncbi.nlm.nih.gov/pubmed/2355237,http://www.ncbi.nlm.nih.gov/pubmed/11761804,http://www.ncbi.nlm.nih.gov/pubmed/8819039,http://www.ncbi.nlm.nih.gov/pubmed/1122928,http://www.ncbi.nlm.nih.gov/pubmed/464793,http://www.ncbi.nlm.nih.gov/pubmed/2208946,http://www.ncbi.nlm.nih.gov/pubmed/26203455,http://www.ncbi.nlm.nih.gov/pubmed/12430042,http://www.ncbi.nlm.nih.gov/pubmed/871409,http://www.ncbi.nlm.nih.gov/pubmed/1217221,http://www.ncbi.nlm.nih.gov/pubmed/24748143,http://www.ncbi.nlm.nih.gov/pubmed/2716993,http://www.ncbi.nlm.nih.gov/pubmed/966632,http://www.ncbi.nlm.nih.gov/pubmed/7110955 | List symptoms of the Zieve's syndrome. | Zieve's syndrome, characterized by jaundice, hyperlipidaemia and haemolytic anaemia. It usually develops in young, chronically alcoholic subjects with enlarged fatty liver. It may rarely occur with intracranial haemorrhage. |
http://www.ncbi.nlm.nih.gov/pubmed/22556134,http://www.ncbi.nlm.nih.gov/pubmed/25161652,http://www.ncbi.nlm.nih.gov/pubmed/28212760,http://www.ncbi.nlm.nih.gov/pubmed/24692521,http://www.ncbi.nlm.nih.gov/pubmed/28052180,http://www.ncbi.nlm.nih.gov/pubmed/26178281,http://www.ncbi.nlm.nih.gov/pubmed/28237512,http://www.ncbi.nlm.nih.gov/pubmed/26882216,http://www.ncbi.nlm.nih.gov/pubmed/21794775,http://www.ncbi.nlm.nih.gov/pubmed/26186277,http://www.ncbi.nlm.nih.gov/pubmed/28733473,http://www.ncbi.nlm.nih.gov/pubmed/24800325,http://www.ncbi.nlm.nih.gov/pubmed/22015150,http://www.ncbi.nlm.nih.gov/pubmed/21317853,http://www.ncbi.nlm.nih.gov/pubmed/27221798 | What is the link between psoriatic arthritis and depression | Depression Is Associated with an Increased Risk of Psoriatic Arthritis among Patients with Psoriasis. Psoriasis is a common chronic inflammatory disease which is associated with extensive comorbidities, including psoriatic arthritis. |
http://www.ncbi.nlm.nih.gov/pubmed/27940037,http://www.ncbi.nlm.nih.gov/pubmed/19479986,http://www.ncbi.nlm.nih.gov/pubmed/23776204,http://www.ncbi.nlm.nih.gov/pubmed/16282984,http://www.ncbi.nlm.nih.gov/pubmed/22400011,http://www.ncbi.nlm.nih.gov/pubmed/9020972,http://www.ncbi.nlm.nih.gov/pubmed/23989958,http://www.ncbi.nlm.nih.gov/pubmed/1684936,http://www.ncbi.nlm.nih.gov/pubmed/16467265,http://www.ncbi.nlm.nih.gov/pubmed/9223284,http://www.ncbi.nlm.nih.gov/pubmed/9733864,http://www.ncbi.nlm.nih.gov/pubmed/26730730,http://www.ncbi.nlm.nih.gov/pubmed/19576221,http://www.ncbi.nlm.nih.gov/pubmed/18177749,http://www.ncbi.nlm.nih.gov/pubmed/28537233,http://www.ncbi.nlm.nih.gov/pubmed/9933592,http://www.ncbi.nlm.nih.gov/pubmed/9611233,http://www.ncbi.nlm.nih.gov/pubmed/3037325,http://www.ncbi.nlm.nih.gov/pubmed/2579655,http://www.ncbi.nlm.nih.gov/pubmed/11557765,http://www.ncbi.nlm.nih.gov/pubmed/9242905,http://www.ncbi.nlm.nih.gov/pubmed/17267594,http://www.ncbi.nlm.nih.gov/pubmed/8440247,http://www.ncbi.nlm.nih.gov/pubmed/16738135,http://www.ncbi.nlm.nih.gov/pubmed/12601000 | Is polyadenylation a process that stabilizes a protein by adding a string of Adenosine residues to the end of the molecule? | No, polyadenylation is a process that stabilizes mRNA by adding up to 200 adenosine residues to the 3' end of the trabscript |
http://www.ncbi.nlm.nih.gov/pubmed/22664948,http://www.ncbi.nlm.nih.gov/pubmed/8272014,http://www.ncbi.nlm.nih.gov/pubmed/16142610,http://www.ncbi.nlm.nih.gov/pubmed/22968735,http://www.ncbi.nlm.nih.gov/pubmed/18018644,http://www.ncbi.nlm.nih.gov/pubmed/3827356,http://www.ncbi.nlm.nih.gov/pubmed/24867050,http://www.ncbi.nlm.nih.gov/pubmed/19089668,http://www.ncbi.nlm.nih.gov/pubmed/11878780,http://www.ncbi.nlm.nih.gov/pubmed/1620943,http://www.ncbi.nlm.nih.gov/pubmed/8091266,http://www.ncbi.nlm.nih.gov/pubmed/16308708,http://www.ncbi.nlm.nih.gov/pubmed/12893072,http://www.ncbi.nlm.nih.gov/pubmed/24840526,http://www.ncbi.nlm.nih.gov/pubmed/19561114,http://www.ncbi.nlm.nih.gov/pubmed/10468897,http://www.ncbi.nlm.nih.gov/pubmed/3361958,http://www.ncbi.nlm.nih.gov/pubmed/12149713,http://www.ncbi.nlm.nih.gov/pubmed/16229813,http://www.ncbi.nlm.nih.gov/pubmed/16555728,http://www.ncbi.nlm.nih.gov/pubmed/17706515 | Which cancers compose Carney's triad? | Carney's triad is a rare pathogenic entity which consists of 3 rare soft tissue tumors: gastric leiomyosarcoma, pulmonary chondroma and extraadrenal paraganglioma. It is usually diagnosed in young women. The presence of three tumors at the same time is not required for its diagnosis (incomplete Carney's Triad). |
http://www.ncbi.nlm.nih.gov/pubmed/28263374,http://www.ncbi.nlm.nih.gov/pubmed/28596452,http://www.ncbi.nlm.nih.gov/pubmed/27474376,http://www.ncbi.nlm.nih.gov/pubmed/19812459 | What is the preDIVA clinical trial? | The preDIVA trial (Prevention of Dementia by Intensive Vascular Care) was an open-label, cluster-randomized controlled trial in community-dwelling individuals aged 70 to 78 years. |
http://www.ncbi.nlm.nih.gov/pubmed/27678025 | What effect does azeliragon have on RAGE? | Azeliragon is an inhibitor of receptor for advanced glycation end products (RAGE). |
http://www.ncbi.nlm.nih.gov/pubmed/23170914,http://www.ncbi.nlm.nih.gov/pubmed/28383856,http://www.ncbi.nlm.nih.gov/pubmed/24030968,http://www.ncbi.nlm.nih.gov/pubmed/25389049,http://www.ncbi.nlm.nih.gov/pubmed/25402624,http://www.ncbi.nlm.nih.gov/pubmed/25418019 | What is the drug forxiga used for? | Dapagliflozin (Forxiga®) is the first in a novel class of glucose-lowering agents known as sodium-glucose co-transporter-2 (SGLT2) inhibitors and is used in the treatment of patients with type 2 diabetes. |
http://www.ncbi.nlm.nih.gov/pubmed/25636632,http://www.ncbi.nlm.nih.gov/pubmed/27376978,http://www.ncbi.nlm.nih.gov/pubmed/23302323,http://www.ncbi.nlm.nih.gov/pubmed/28784156,http://www.ncbi.nlm.nih.gov/pubmed/27932370,http://www.ncbi.nlm.nih.gov/pubmed/28523334,http://www.ncbi.nlm.nih.gov/pubmed/28228892,http://www.ncbi.nlm.nih.gov/pubmed/28109372,http://www.ncbi.nlm.nih.gov/pubmed/22206790,http://www.ncbi.nlm.nih.gov/pubmed/28410845 | What is the most common feature of the Doege–Potter syndrome? | Doege-Potter syndrome is a paraneoplastic syndrome characterized by hypoglycemia secondary to a solitary fibrous tumor of the pleura. |
http://www.ncbi.nlm.nih.gov/pubmed/24708671,http://www.ncbi.nlm.nih.gov/pubmed/19263274,http://www.ncbi.nlm.nih.gov/pubmed/26639059,http://www.ncbi.nlm.nih.gov/pubmed/18305449,http://www.ncbi.nlm.nih.gov/pubmed/28559126,http://www.ncbi.nlm.nih.gov/pubmed/25156675,http://www.ncbi.nlm.nih.gov/pubmed/27730539 | Milwaukee protocol was tested for treatment of which disease? | The Milwaukee protocol was tested for treatment of rabies. Therapies suggested in the Milwaukee protocol include therapeutic coma, ketamine infusion, amantadine, and the screening/prophylaxis/management of cerebral vasospasm. The Milwaukee Protocol has proved to be ineffective for rabies and should no longer be used. |
http://www.ncbi.nlm.nih.gov/pubmed/28377462,http://www.ncbi.nlm.nih.gov/pubmed/27838525,http://www.ncbi.nlm.nih.gov/pubmed/23279909,http://www.ncbi.nlm.nih.gov/pubmed/28306503 | Are stress granules membraneous? | Stress granules (SG) are membrane-less compartments involved in regulating mRNAs during stress. |
http://www.ncbi.nlm.nih.gov/pubmed/28207855,http://www.ncbi.nlm.nih.gov/pubmed/28103917,http://www.ncbi.nlm.nih.gov/pubmed/27984802,http://www.ncbi.nlm.nih.gov/pubmed/29107843 | When is 16S rRNA Gene Sequencing used? | Taxonomic characterization is performed by genotypic approaches such as 16S rRNA gene sequencing. |
http://www.ncbi.nlm.nih.gov/pubmed/28253832 | What does intepirdine target? | Intepiridine is a 5-HT6 antagonist. |
http://www.ncbi.nlm.nih.gov/pubmed/26936339,http://www.ncbi.nlm.nih.gov/pubmed/26983749,http://www.ncbi.nlm.nih.gov/pubmed/27493901,http://www.ncbi.nlm.nih.gov/pubmed/29141542,http://www.ncbi.nlm.nih.gov/pubmed/27164919,http://www.ncbi.nlm.nih.gov/pubmed/28356040,http://www.ncbi.nlm.nih.gov/pubmed/28824916,http://www.ncbi.nlm.nih.gov/pubmed/22169919,http://www.ncbi.nlm.nih.gov/pubmed/18827977,http://www.ncbi.nlm.nih.gov/pubmed/20858571,http://www.ncbi.nlm.nih.gov/pubmed/28324761,http://www.ncbi.nlm.nih.gov/pubmed/28649567,http://www.ncbi.nlm.nih.gov/pubmed/21666964,http://www.ncbi.nlm.nih.gov/pubmed/22653982,http://www.ncbi.nlm.nih.gov/pubmed/24274771,http://www.ncbi.nlm.nih.gov/pubmed/27088635,http://www.ncbi.nlm.nih.gov/pubmed/11790962 | Is the consumption of chocolate associated with an increase in cardiovascular disease? | The consumption of natural polyphenol-rich foods, and cocoa in particular, has been related to a reduced risk of CVD, including coronary heart disease and stroke.Chocolate consumption can reduce cardio-cerebrovascular risk. |
http://www.ncbi.nlm.nih.gov/pubmed/28484086,http://www.ncbi.nlm.nih.gov/pubmed/27829232 | What is the association of circular RNA to breast cancer? | circRNAs are differentially expressed in breast cancer and are important in carcinogenesis because they participate in cancer-related pathways and sequester miRNAs. circRNA frequency may be a marker for cell proliferation in breast cancer. |
http://www.ncbi.nlm.nih.gov/pubmed/17698536,http://www.ncbi.nlm.nih.gov/pubmed/25856744,http://www.ncbi.nlm.nih.gov/pubmed/27988455,http://www.ncbi.nlm.nih.gov/pubmed/25550705,http://www.ncbi.nlm.nih.gov/pubmed/22869492,http://www.ncbi.nlm.nih.gov/pubmed/26869612,http://www.ncbi.nlm.nih.gov/pubmed/23935638,http://www.ncbi.nlm.nih.gov/pubmed/27300674,http://www.ncbi.nlm.nih.gov/pubmed/28289649,http://www.ncbi.nlm.nih.gov/pubmed/14644703,http://www.ncbi.nlm.nih.gov/pubmed/16219837 | List 3 symptoms of Wernicke encephalopathy. | Wernicke's encephalopathy (WE) is a neurological syndrome caused by thiamine deficiency, and clinically characterized by ophthalmoplegia, ataxia and acute confusion.Wernicke's encephalopathy (WE) is a neurological syndrome caused by thiamine deficiency, and clinically characterized by ophthalmoplegia, ataxia and acute confusion. |
http://www.ncbi.nlm.nih.gov/pubmed/28459942 | Describe RIblast | LncRNAs play important roles in various biological processes. Although more than 58 000 human lncRNA genes have been discovered, most known lncRNAs are still poorly characterized. One approach to understanding the functions of lncRNAs is the detection of the interacting RNA target of each lncRNA. Because experimental detections of comprehensive lncRNA-RNA interactions are difficult, computational prediction of lncRNA-RNA interactions is an indispensable technique. However, the high computational costs of existing RNA-RNA interaction prediction tools prevent their application to large-scale lncRNA datasets. 'RIblast' is an ultrafast RNA-RNA interaction prediction method based on the seed-and-extension approach. RIblast discovers seed regions using suffix arrays and subsequently extends seed regions based on an RNA secondary structure energy model. Computational experiments indicate that RIblast achieves a level of prediction accuracy similar to those of existing programs, but at speeds over 64 times faster than existing programs. |
http://www.ncbi.nlm.nih.gov/pubmed/27358062,http://www.ncbi.nlm.nih.gov/pubmed/28921611,http://www.ncbi.nlm.nih.gov/pubmed/28025282,http://www.ncbi.nlm.nih.gov/pubmed/27815399 | What is Alzheimers disease resilience? | Some 30 to 50% of older individuals who harbor AD pathology do not become symptomatic in their lifetime. It is hypothesized that such individuals exhibit cognitive resilience that protects against AD dementia. |
http://www.ncbi.nlm.nih.gov/pubmed/24990604 | Which R package has been developed for analyzing Non-invasive prenatal testing (NIPT) data? | Non-invasive prenatal testing (NIPT) of fetal aneuploidy using cell-free fetal DNA is becoming part of routine clinical practice. RAPIDR (Reliable Accurate Prenatal non-Invasive Diagnosis R package) is an easy-to-use open-source R package that implements several published NIPT analysis methods. The input to RAPIDR is a set of sequence alignment files in the BAM format, and the outputs are calls for aneuploidy, including trisomies 13, 18, 21 and monosomy X as well as fetal sex. RAPIDR has been extensively tested with a large sample set as part of the RAPID project in the UK. The package contains quality control steps to make it robust for use in the clinical setting.RAPIDR (Reliable Accurate Prenatal non-Invasive Diagnosis R package) is an easy-to-use open-source R package that implements several published NIPT analysis methods. The input to RAPIDR is a set of sequence alignment files in the BAM format, and the outputs are calls for aneuploidy, including trisomies 13, 18, 21 and monosomy X as well as fetal sex. |
http://www.ncbi.nlm.nih.gov/pubmed/15304099,http://www.ncbi.nlm.nih.gov/pubmed/28830827,http://www.ncbi.nlm.nih.gov/pubmed/475444,http://www.ncbi.nlm.nih.gov/pubmed/12406345,http://www.ncbi.nlm.nih.gov/pubmed/10620111 | Is the gene CDKN2A nevogenic? | Yes, CDKN2A is nevogenic |
http://www.ncbi.nlm.nih.gov/pubmed/27407109 | Are there ways of joint Bayesian inference of risk variants? | Yes. RiVIERA (Risk Variant Inference using Epigenomic Reference Annotations) is a Bayesian model for inference of driver variants from summary statistics across multiple traits using hundreds of epigenomic annotations. |
http://www.ncbi.nlm.nih.gov/pubmed/26774542,http://www.ncbi.nlm.nih.gov/pubmed/12162986,http://www.ncbi.nlm.nih.gov/pubmed/26669687,http://www.ncbi.nlm.nih.gov/pubmed/24021741,http://www.ncbi.nlm.nih.gov/pubmed/2373612 | Describe Achenbach’s syndrome. | Achenbach’s syndrome is Paroxysmal finger haematoma. It is benign condition resulting in the sudden appearance of bruising on one or more fingers, either spontaneously or after minimal trauma, and resolving without treatment.It can be differentiated from other pathologies by clinical spectrum, patient demographics and in doubtful circumstances (acute limb ischemia) by Doppler sonography. |
http://www.ncbi.nlm.nih.gov/pubmed/28720101 | Has intepirdine been evaluated in clinical trials? (November 2017) | Yes, intepirdine was in Phase III clinical trials in November 2017. |
http://www.ncbi.nlm.nih.gov/pubmed/28750182,http://www.ncbi.nlm.nih.gov/pubmed/26765654,http://www.ncbi.nlm.nih.gov/pubmed/28116334,http://www.ncbi.nlm.nih.gov/pubmed/21311432,http://www.ncbi.nlm.nih.gov/pubmed/15464644,http://www.ncbi.nlm.nih.gov/pubmed/26587021,http://www.ncbi.nlm.nih.gov/pubmed/15384893,http://www.ncbi.nlm.nih.gov/pubmed/29062617,http://www.ncbi.nlm.nih.gov/pubmed/23188587,http://www.ncbi.nlm.nih.gov/pubmed/2019970,http://www.ncbi.nlm.nih.gov/pubmed/27777245,http://www.ncbi.nlm.nih.gov/pubmed/25761293,http://www.ncbi.nlm.nih.gov/pubmed/29112137,http://www.ncbi.nlm.nih.gov/pubmed/1468866,http://www.ncbi.nlm.nih.gov/pubmed/6685828,http://www.ncbi.nlm.nih.gov/pubmed/15566859,http://www.ncbi.nlm.nih.gov/pubmed/2807674,http://www.ncbi.nlm.nih.gov/pubmed/15246492,http://www.ncbi.nlm.nih.gov/pubmed/21245918,http://www.ncbi.nlm.nih.gov/pubmed/2774513,http://www.ncbi.nlm.nih.gov/pubmed/6879001,http://www.ncbi.nlm.nih.gov/pubmed/18037676,http://www.ncbi.nlm.nih.gov/pubmed/22408143,http://www.ncbi.nlm.nih.gov/pubmed/27634625,http://www.ncbi.nlm.nih.gov/pubmed/25802788,http://www.ncbi.nlm.nih.gov/pubmed/11545478,http://www.ncbi.nlm.nih.gov/pubmed/28387784,http://www.ncbi.nlm.nih.gov/pubmed/15557053 | Is subacute sclerosing panencephalitis caused by the Measles vaccine? | Subacute sclerosing panencephalitis is caused by the Measles and can be prevented by the measles vaccine.Subacute sclerosing panencephalitis (SSPE) is a potentially fatal complication of measles. |
http://www.ncbi.nlm.nih.gov/pubmed/28967180 | What is host induced gene silencing? | Host-induced gene silencing (HIGS) is a transgenic technology used to silence fungal genes in planta during attempted infection and thereby reduces disease levels. HIGS relies on the host plant's ability to produce mobile small interfering RNA molecules, generated from long double-stranded RNA, which are complementary to targeted fungal genes. These molecules are transferred from the plant to invading fungi via an uncharacterised mechanism, to cause gene silencing. |
http://www.ncbi.nlm.nih.gov/pubmed/28092013 | What is maternal spindle transfer? | Maternal spindle transfer (MST) is a cutting edge germline-altering, IVF-based embryonic technique used to prevent the maternal transmission of serious mitochondrial diseases. |
http://www.ncbi.nlm.nih.gov/pubmed/26902850 | Does armodafinil improve fatigue of glioma patients? | No. Eight week course of armodafinil did not improve fatigue or quality of life in glioma patients undergoing radiotherapy. However, this conclusion is based on one identified clinical trial. |
http://www.ncbi.nlm.nih.gov/pubmed/26845027 | What is the role of tankyrases in response to Double Strand Breaks (DSBs)? | Tankyrases promote homologous recombination and check point activation in response to DSBs. |
http://www.ncbi.nlm.nih.gov/pubmed/26149476,http://www.ncbi.nlm.nih.gov/pubmed/29101463,http://www.ncbi.nlm.nih.gov/pubmed/28183331,http://www.ncbi.nlm.nih.gov/pubmed/25683141,http://www.ncbi.nlm.nih.gov/pubmed/27267856,http://www.ncbi.nlm.nih.gov/pubmed/27082062,http://www.ncbi.nlm.nih.gov/pubmed/28213002,http://www.ncbi.nlm.nih.gov/pubmed/28714017,http://www.ncbi.nlm.nih.gov/pubmed/23443805,http://www.ncbi.nlm.nih.gov/pubmed/23908597,http://www.ncbi.nlm.nih.gov/pubmed/26723100,http://www.ncbi.nlm.nih.gov/pubmed/22180308,http://www.ncbi.nlm.nih.gov/pubmed/28736761,http://www.ncbi.nlm.nih.gov/pubmed/27705940,http://www.ncbi.nlm.nih.gov/pubmed/23041231,http://www.ncbi.nlm.nih.gov/pubmed/27216979,http://www.ncbi.nlm.nih.gov/pubmed/27315356,http://www.ncbi.nlm.nih.gov/pubmed/27245147,http://www.ncbi.nlm.nih.gov/pubmed/28377480,http://www.ncbi.nlm.nih.gov/pubmed/27100354,http://www.ncbi.nlm.nih.gov/pubmed/27025387,http://www.ncbi.nlm.nih.gov/pubmed/28342996 | Which molecules are inhibited by anticancer drug Dovitinib? | Dovitinib (TKI-258/CHIR-258) is a pan receptor tyrosine kinase (RTK) inhibitor that targets VEGFR, FGFR, PDGFR, and KIT. It is being widely tested for treatment of various cancers. |
http://www.ncbi.nlm.nih.gov/pubmed/28903484,http://www.ncbi.nlm.nih.gov/pubmed/28622299 | How do circRNAs relate to tumorigenesis? | Circular RNA may promote or repress tumorigenesis. |
http://www.ncbi.nlm.nih.gov/pubmed/27569544 | Which method is available for whole genome identification of pathogenic regulatory variants in mendelian disease? | Genomiser |
http://www.ncbi.nlm.nih.gov/pubmed/26633090,http://www.ncbi.nlm.nih.gov/pubmed/28328324 | Is pregabalin effective for sciatica? | No. Treatment with pregabalin did not significantly reduce the intensity of leg pain associated with sciatica and did not significantly improve other outcomes, as compared with placebo, over the course of 8 weeks. The incidence of adverse events was significantly higher in the pregabalin group than in the placebo group. |
http://www.ncbi.nlm.nih.gov/pubmed/27351374 | Can gas vesicles be detected by ultrasound? | Gas vesicles have been identified as nanoscale reporters for ultrasound. |
http://www.ncbi.nlm.nih.gov/pubmed/28720101 | In what phase of clinical trials is crenezumab? (November 2017) | Crenezumab is undergoing phase III clinical trials. |
http://www.ncbi.nlm.nih.gov/pubmed/28633445 | Which sequence-based algorithm for branch point prediction has been proposed? | BPP is a sequence-based algorithm for branch point prediction. |
http://www.ncbi.nlm.nih.gov/pubmed/10405382,http://www.ncbi.nlm.nih.gov/pubmed/19868695,http://www.ncbi.nlm.nih.gov/pubmed/23305889,http://www.ncbi.nlm.nih.gov/pubmed/19868926,http://www.ncbi.nlm.nih.gov/pubmed/8219499,http://www.ncbi.nlm.nih.gov/pubmed/15232184,http://www.ncbi.nlm.nih.gov/pubmed/26850399,http://www.ncbi.nlm.nih.gov/pubmed/2772682,http://www.ncbi.nlm.nih.gov/pubmed/17532590,http://www.ncbi.nlm.nih.gov/pubmed/24168973,http://www.ncbi.nlm.nih.gov/pubmed/23735582,http://www.ncbi.nlm.nih.gov/pubmed/23639381,http://www.ncbi.nlm.nih.gov/pubmed/8440944,http://www.ncbi.nlm.nih.gov/pubmed/19947304,http://www.ncbi.nlm.nih.gov/pubmed/2045646,http://www.ncbi.nlm.nih.gov/pubmed/10961536,http://www.ncbi.nlm.nih.gov/pubmed/28322696,http://www.ncbi.nlm.nih.gov/pubmed/1500078 | What organism causes scarlet fever also known as scarletina? | Scarlet fever is a disease which can occur as a result of a group A streptococcus (group A strep), group C Streptococcus and Streptococcus hemolyticus infection. |
http://www.ncbi.nlm.nih.gov/pubmed/28716596,http://www.ncbi.nlm.nih.gov/pubmed/15812389,http://www.ncbi.nlm.nih.gov/pubmed/18682250 | What is the BioArchive system? | A small-scale automated cryopreservation and storage system (Mini-BioArchive system) used in the banking of umbilical cord blood (UCB) units. |
http://www.ncbi.nlm.nih.gov/pubmed/28334390 | Which algorithm has been proposed for efficient storage of WGS variant calls? | Whole-genome sequencing (WGS) data are being generated at an unprecedented rate. Analysis of WGS data requires a flexible data format to store the different types of DNA variation. Variant call format (VCF) is a general text-based format developed to store variant genotypes and their annotations. However, VCF files are large and data retrieval is relatively slow. 'SeqArray' is a new WGS variant data format implemented in the R/Bioconductor package for storing variant calls in an array-oriented manner which provides the same capabilities as VCF, but with multiple high compression options and data access using high-performance parallel computing. |
http://www.ncbi.nlm.nih.gov/pubmed/28085133,http://www.ncbi.nlm.nih.gov/pubmed/27624779,http://www.ncbi.nlm.nih.gov/pubmed/27821583,http://www.ncbi.nlm.nih.gov/pubmed/27633986 | Is Citrobacter rodentium pathogenic? | Yes, the mouse pathogen Citrobacter rodentium, colonize the gut mucosa via attaching and effacing lesion formation and cause diarrheal diseases. |
http://www.ncbi.nlm.nih.gov/pubmed/27905086,http://www.ncbi.nlm.nih.gov/pubmed/28121498,http://www.ncbi.nlm.nih.gov/pubmed/25451052,http://www.ncbi.nlm.nih.gov/pubmed/28274145,http://www.ncbi.nlm.nih.gov/pubmed/25486992,http://www.ncbi.nlm.nih.gov/pubmed/28730660,http://www.ncbi.nlm.nih.gov/pubmed/27757389 | List two human monoclonal antibodies against Clostridium difficile toxins. | Actoxumab and bezlotoxumab are human monoclonal antibodies against C. difficile toxins A and B, respectively. They were shown to decrease Clostridium difficile recurrence. Bezlotoxumab was approved by the Food and Drug Administration and the European Medicines Agency for Clostridium difficile recurrence. |
http://www.ncbi.nlm.nih.gov/pubmed/28332494,http://www.ncbi.nlm.nih.gov/pubmed/27994142,http://www.ncbi.nlm.nih.gov/pubmed/28123053,http://www.ncbi.nlm.nih.gov/pubmed/29143558,http://www.ncbi.nlm.nih.gov/pubmed/28549781 | List ribosomal biogenesis proteins. | FGF13
p53
TGFβ/Activin
PTEN
Nucleostemin
HEATR1 |
http://www.ncbi.nlm.nih.gov/pubmed/14602918,http://www.ncbi.nlm.nih.gov/pubmed/28213517,http://www.ncbi.nlm.nih.gov/pubmed/28241136 | Which protein is regulated by Tudor interacting repair regulator (TIRR)? | Tudor interacting repair regulator (TIRR) regulates P53-binding protein 1 (53BP1) by masking its histone methyl-lysine binding function. |
http://www.ncbi.nlm.nih.gov/pubmed/28887402 | Which algorithm is used for detection of long repeat expansions? | Identifying large expansions of short tandem repeats (STRs), such as those that cause amyotrophic lateral sclerosis (ALS) and fragile X syndrome, is challenging for short-read whole-genome sequencing (WGS) data. A solution to this problem is an important step toward integrating WGS into precision medicine. For that purpose, ExpansionHunter has been developed as a software tool that, using PCR-free WGS short-read data, can genotype repeats at the locus of interest, even if the expanded repeat is larger than the read length. |
http://www.ncbi.nlm.nih.gov/pubmed/28959975 | Which brain tumors does neuroligin-3 promote? | Neuroligin-3 promotes the growth of high-grade gliomas. |
http://www.ncbi.nlm.nih.gov/pubmed/27484196 | Which web resource for LIR motif-containing proteins in eukaryotes has been developed? | In the past few years it has been revealed that Atg8-interacting proteins include not only receptors but also components of the core autophagic machinery, proteins associated with vesicles and their transport, and specific proteins that are selectively degraded by autophagy. Atg8-interacting proteins contain a short linear LC3-interacting region/LC3 recognition sequence/Atg8-interacting motif (LIR/LRS/AIM) motif which is responsible for their interaction with Atg8-family proteins. These proteins are referred to as LIR-containing proteins (LIRCPs). So far, many experimental efforts have been carried out to identify new LIRCPs, leading to the characterization of some of them in the past 10 years. Given the need for the identification of LIRCPs in various organisms, the iLIR database ( https://ilir.warwick.ac.uk ) has been developed as a freely available web resource, listing all the putative canonical LIRCPs identified in silico in the proteomes of 8 model organisms using the iLIR server, combined with a Gene Ontology (GO) term analysis. |
http://www.ncbi.nlm.nih.gov/pubmed/27725777,http://www.ncbi.nlm.nih.gov/pubmed/28980860,http://www.ncbi.nlm.nih.gov/pubmed/25436423 | What is liquid liquid phase transition? | The influence of membrane-free microcompartments resulting from crowding-induced liquid/liquid phase separation (LLPS) on the dynamic spatial organization of FtsZ, the main component of the bacterial division machinery, has been studied using several LLPS systems. |
http://www.ncbi.nlm.nih.gov/pubmed/26205796,http://www.ncbi.nlm.nih.gov/pubmed/23020629,http://www.ncbi.nlm.nih.gov/pubmed/22696589,http://www.ncbi.nlm.nih.gov/pubmed/22077430,http://www.ncbi.nlm.nih.gov/pubmed/25237200,http://www.ncbi.nlm.nih.gov/pubmed/28657829,http://www.ncbi.nlm.nih.gov/pubmed/11843289,http://www.ncbi.nlm.nih.gov/pubmed/23765390,http://www.ncbi.nlm.nih.gov/pubmed/27812245,http://www.ncbi.nlm.nih.gov/pubmed/28516949 | Can CD55 deficiency cause thrombosis? | Yes, loss of CD55 is associated with thrombosis in patients with Paroxysmal nocturnal hemoglobinuria. CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy (the CHAPLE syndrome) is caused by abnormal complement activation due to biallelic loss-of-function mutations in CD55 |
http://www.ncbi.nlm.nih.gov/pubmed/807555 | What is the approximate size of gas vesicles? | The diameter of gas vesicles is approximately 100nm. |
http://www.ncbi.nlm.nih.gov/pubmed/28209226,http://www.ncbi.nlm.nih.gov/pubmed/16293956,http://www.ncbi.nlm.nih.gov/pubmed/28992834,http://www.ncbi.nlm.nih.gov/pubmed/3542725,http://www.ncbi.nlm.nih.gov/pubmed/20351955,http://www.ncbi.nlm.nih.gov/pubmed/331948,http://www.ncbi.nlm.nih.gov/pubmed/7774322,http://www.ncbi.nlm.nih.gov/pubmed/28040290,http://www.ncbi.nlm.nih.gov/pubmed/22160956,http://www.ncbi.nlm.nih.gov/pubmed/10613491,http://www.ncbi.nlm.nih.gov/pubmed/22520295,http://www.ncbi.nlm.nih.gov/pubmed/25252161,http://www.ncbi.nlm.nih.gov/pubmed/17655678,http://www.ncbi.nlm.nih.gov/pubmed/27914359,http://www.ncbi.nlm.nih.gov/pubmed/28181212,http://www.ncbi.nlm.nih.gov/pubmed/22826063,http://www.ncbi.nlm.nih.gov/pubmed/18024169,http://www.ncbi.nlm.nih.gov/pubmed/8178007,http://www.ncbi.nlm.nih.gov/pubmed/16149210,http://www.ncbi.nlm.nih.gov/pubmed/3106890,http://www.ncbi.nlm.nih.gov/pubmed/2654251 | Are sleep apnea and snoring associated with cardiac arrhythmias? | Evidence supports a causal association of sleep apnea with the incidence and morbidity of hypertension, coronary heart disease, arrhythmia, heart failure, and stroke. |
http://www.ncbi.nlm.nih.gov/pubmed/27761364,http://www.ncbi.nlm.nih.gov/pubmed/22090285,http://www.ncbi.nlm.nih.gov/pubmed/24088021,http://www.ncbi.nlm.nih.gov/pubmed/23742809,http://www.ncbi.nlm.nih.gov/pubmed/26466547 | Are osteoclasts specialized in bone degradation? | Bone degradation is caused by osteoclasts, the normal bone-resorbing cells. |
http://www.ncbi.nlm.nih.gov/pubmed/28068333,http://www.ncbi.nlm.nih.gov/pubmed/28733670,http://www.ncbi.nlm.nih.gov/pubmed/28063381,http://www.ncbi.nlm.nih.gov/pubmed/25575605,http://www.ncbi.nlm.nih.gov/pubmed/26590112 | List BET proteins. | BRD2
BRD3
BRD4
Bdf1 |
http://www.ncbi.nlm.nih.gov/pubmed/21493184,http://www.ncbi.nlm.nih.gov/pubmed/24692729,http://www.ncbi.nlm.nih.gov/pubmed/27143690,http://www.ncbi.nlm.nih.gov/pubmed/28259301,http://www.ncbi.nlm.nih.gov/pubmed/16012795,http://www.ncbi.nlm.nih.gov/pubmed/23099651,http://www.ncbi.nlm.nih.gov/pubmed/22033322,http://www.ncbi.nlm.nih.gov/pubmed/17538086 | Does temsirolimus improve survival of glioblastoma patients? | No. Temsirolimus does not prolong survival of gliobalstoma patients. |
http://www.ncbi.nlm.nih.gov/pubmed/27989944,http://www.ncbi.nlm.nih.gov/pubmed/28453668,http://www.ncbi.nlm.nih.gov/pubmed/28414281,http://www.ncbi.nlm.nih.gov/pubmed/26670565 | What is the proteoform? | Although proteomics has rapidly developed in the past decade, researchers are still in the early stage of exploring the world of complex proteoforms, which are protein products with various primary structure alterations resulting from gene mutations, alternative splicing, post-translational modifications, and other biological processes |
http://www.ncbi.nlm.nih.gov/pubmed/28302071 | Are there sex differences in the transcriptome of the mouse hippocampus? | There are sex differences in the transcriptome of the developing mouse hippocampus. |
http://www.ncbi.nlm.nih.gov/pubmed/25957677 | How does neuronal activity affect neuroligin-3? | Neuronal activity-induces secretion of neuroligin-3. |
http://www.ncbi.nlm.nih.gov/pubmed/27425887,http://www.ncbi.nlm.nih.gov/pubmed/27633771,http://www.ncbi.nlm.nih.gov/pubmed/19664711,http://www.ncbi.nlm.nih.gov/pubmed/26995317 | What is the role of the blood-brain barrier? | The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS). The blood–brain barrier is formed by brain endothelial cells and it allows the passage of water, some gases, and lipid-soluble molecules by passive diffusion, as well as the selective transport of molecules such as glucose and amino acids that are crucial to neural function. |
http://www.ncbi.nlm.nih.gov/pubmed/20043874,http://www.ncbi.nlm.nih.gov/pubmed/27342581,http://www.ncbi.nlm.nih.gov/pubmed/25248363,http://www.ncbi.nlm.nih.gov/pubmed/23737439,http://www.ncbi.nlm.nih.gov/pubmed/22836717,http://www.ncbi.nlm.nih.gov/pubmed/28571484,http://www.ncbi.nlm.nih.gov/pubmed/24949665,http://www.ncbi.nlm.nih.gov/pubmed/26826396,http://www.ncbi.nlm.nih.gov/pubmed/24151757,http://www.ncbi.nlm.nih.gov/pubmed/22206666,http://www.ncbi.nlm.nih.gov/pubmed/27742498,http://www.ncbi.nlm.nih.gov/pubmed/27965160,http://www.ncbi.nlm.nih.gov/pubmed/12702725,http://www.ncbi.nlm.nih.gov/pubmed/23233270,http://www.ncbi.nlm.nih.gov/pubmed/23845326,http://www.ncbi.nlm.nih.gov/pubmed/21991382,http://www.ncbi.nlm.nih.gov/pubmed/28081119,http://www.ncbi.nlm.nih.gov/pubmed/22082361,http://www.ncbi.nlm.nih.gov/pubmed/21890009,http://www.ncbi.nlm.nih.gov/pubmed/21312267 | Sclerostin regulates what process? | Sclerostin plays a critical role in bone homeostasis and its deficiency or pharmacological neutralization increases bone formation |
http://www.ncbi.nlm.nih.gov/pubmed/28255272,http://www.ncbi.nlm.nih.gov/pubmed/28510338,http://www.ncbi.nlm.nih.gov/pubmed/28069876 | What is PARP inhibitor (PARPi) resistance? | PARPi has been designed and tested for many years and became a potential supplement for the conventional chemotherapy. However, increasing evidence indicates the appearance of the resistance to this treatment. Specifically, cancer cells may acquire new mutations or events that overcome the positive effect of these drugs. |
http://www.ncbi.nlm.nih.gov/pubmed/26082458 | What is the association of the protein RAB10 and Alzheimers disease? | The genes SEC22B, RAB10 and FLT1 may be potential biomarkers of AD. |
http://www.ncbi.nlm.nih.gov/pubmed/28869973 | Does MC1R palmitoylation reduce pigmentation? | No, MC1R palmitoylation leads to increased pigmentation. |
http://www.ncbi.nlm.nih.gov/pubmed/28319627,http://www.ncbi.nlm.nih.gov/pubmed/24690977 | A bite from the Lone Star Tick Amblyomma americanum, can cause the victim to become allergic to red meat, yes or no? | Conditions such as Southern tick-associated rash illness and anaphylaxis to red meat following tick bites have been attributed to the lone star tick, Ambyomma ameriacanum..Recently described conditions such as Southern tick-associated rash illness and anaphylaxis to red meat following tick bites have been attributed to the lone star tick. |