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List two most common symptoms of Aagenaes syndrome.

Aagenaes syndrome, also called lymphoedema cholestasis syndrome 1, is characterized by neonatal intrahepatic cholestasis, often lessening and becoming intermittent with age and severe chronic lymphoedema, mainly affecting the lower extremities.

List active ingredients of the Stribild polypill.

Active ingredients of Stribild are elvitegravir, cobicistat, emtricitabine and tenofovir. It is used for treatment of HIV infection.

Is there an increased risk for cancer in Dyskeratosis Congenita?

People with DC are at increased risk for progressive bone marrow failure (BMF), myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML), solid tumors (usually squamous cell carcinoma of the head/neck or anogenital cancer), and pulmonary fibrosis

What is the association between NT-proBNP and cognitive function?

Greater NT-proBNP serum concentration is associated with poorer cognitive function and cognitive decline. In community-dwelling older adults, greater NT-proBNP levels were strongly associated with poor cognitive function independently from age, sex, education, hypertension, body mass index, exercise, alcohol use, smoking, low density lipoprotein cholesterol, creatinine clearance, and previous cardiovascular disease. However, other authors did not find an association between NT-proBNP and severe cognitive impairment (SCI).

What is the molecular function of psoralen photobinding on DNA?

The interaction of two water-soluble furocoumarins, 8-(omega-diethyl aminopropyloxy)psoralen hydrochloride (I) and its 5-isomer (II), with DNA has been investigated by spectroscopic, equilibrium dialysis, hydrodynamic and chiroptical techniques. Both compounds intercalate into the polynucleotide double helix.

Approximately how many genes are contained in the X chromosome's non-pseudoautosomal region (non-PAR)?

The total number of genes contained in the X chromosome's non- pseudoautosomal region (PAR) is 783.

Is progesterone effective for treatment of patients with traumatic brain injury based on clinical trial data?

No. Progesterone has been associated with robust positive effects in animal models of traumatic brain injury (TBI) and with clinical benefits in two phase 2 randomized, controlled trials. However, a recent large clinical trial showed no clinical benefit of progesterone in patients with severe TBI. These data stand in contrast to the robust preclinical data and results of early single-center trials that provided the impetus to initiate phase 3 trials.

Which tool is used to visualise the junction sites of chloroplast genomes?

IRscope is an online program to visualize the junction sites of chloroplast genomes. It allows the users to depict the genetic architecture of up to ten chloroplast genomes in the vicinity of the sites connecting the inverted repeats to the short and long single copy regions. The software and its dependent libraries are fully coded in R and the reflected plot is scaled up to realistic size of nucleotide base pairs in the vicinity of the junction sites. The input of the program is an annotation GenBank (.gb) file, the accession or GI number of the sequence or a DOGMA output file.

What is the aim of the "Radiogenomics Consortium"?

A major aim of research in radiogenomics is the development of a predictive instrument to enable identification of people who are at greatest risk for adverse effects resulting from cancer treatment using radiation. An important effort to advance radiobiology in the genomic era was establishment of the Radiogenomics Consortium to enable the creation of the large radiotherapy cohorts required to exploit advances in genomics.

Which algorithms are used for compression of SAM files?

The most popular format for genomic data is the SAM (Sequence Alignment/Map) format, which contains information such as alignment, quality values, etc. These files are large (on the order of terabytes), which necessitates compression. GeneComp, NGC, SAMZIP and QVZ are algorithms which perform compression of data stored in SAM files.

Is MK-1602 a CGRP antagonist?

Yes, MK-1602 is a CGRP antagonist.

Which domain allowing self-association do exist in TDP-43 and FUS proteins?

PRION PROTEINS

What is PhenomeCentral?

The discovery of disease-causing mutations typically requires confirmation of the variant or gene in multiple unrelated individuals, and a large number of rare genetic diseases remain unsolved due to difficulty identifying second families. The PhenomeCentral portal (https://phenomecentral.org) enables the secure sharing of case records by clinicians and rare disease scientists. PhenomeCentral identifies similar patients in the database based on semantic similarity between clinical features, automatically prioritized genes from whole-exome data, and candidate genes entered by the users, enabling both hypothesis-free and hypothesis-driven matchmaking. Users can then contact other submitters to follow up on promising matches. PhenomeCentral incorporates data for over 1,000 patients with rare genetic diseases, contributed by the FORGE and Care4Rare Canada projects, the US NIH Undiagnosed Diseases Program, the EU Neuromics and ANDDIrare projects, as well as numerous independent clinicians and scientists. Though the majority of these records have associated exome data, most lack a molecular diagnosis. PhenomeCentral has already been used to identify causative mutations for several patients, and its ability to find matching patients and diagnose these diseases will grow with each additional patient that is entered.

Intact macromolecular assemblies are analysed by advanced mass spectrometry. How large complexes (in molecular weight) have been studied?

2.3 megadalton

What pharmacological and non-pharmacological interventions can be considered as prophylactic therapies in Cluster Headache patients?

Verapamil, a calcium channel blocker, is considered the mainstay of prophylactic therapy of Cluster Headache patients. Lithium carbonate, topiramate, valproic acid, gabapentin, baclofen, methysergide, melatonin, ketoprofen and indomethacin can also be tried for prophylactic therapy of Cluster Headaches patients. Non-pharmacological prophylactic measures, such as peripheral (mostly occipital nerve) and central (hypothalamic) neurostimulation, ablative surgery, and botulinum toxin type-A (BTX-A) injection, can be also considered.

Is there any role of the 'Greek islands' in olfactory receptor choice?

Yes. 'Greek islands' first contribute to the formation of olfactory receptor compartments and then form a multi-chromosomal super-enhancer that associates with the single active olfactory receptor gene. The Greek-island-bound transcription factor LHX2 and adaptor protein LDB1 regulate the assembly and maintenance of olfactory receptor compartments, Greek island hubs and olfactory receptor transcription, providing mechanistic insights into and functional support for the role of trans interactions in gene expression.

How many different mutations have been associated with Muenke syndrome?

Muenke syndrome, also known as FGFR3-associated coronal synostosis, is defined molecularly by the presence of a heterozygous nucleotide transversion, c.749C>G, encoding the amino acid substitution Pro250Arg, in the fibroblast growth factor receptor type 3 gene (FGFR3).

Why are insulators necessary in gene therapy vectors?

a) They inhibit oncogene activation upon vector integration and b) They maximize the probability of vector expression upon integration in heterochromatinic regions

How does amphiregulin decrease the anti-proliferative effect of cetuximab?

In SNU-C4 and Caco-2 cells which were relatively sensitive to cetuximab among the seven CRC cell lines tested, AREG significantly decreased the anti-proliferative effect of cetuximab (p < 0.05) via AKT and ERK activation.

What is the function of GvpA?

The gas vesicle wall is solely formed of proteins with the two major components, GvpA and GvpC, and

List the components of a Replisome Progression Complex (RPC).

RPC components include the essential initiation and elongation factor, Cdc45, the checkpoint mediator Mrc1, the Tof1-Csm3 complex that allows replication forks to pause at protein-DNA barriers, the histone chaperone FACT (facilitates chromatin transcription) and Ctf4, which helps to establish sister chromatid cohesion. RPCs also interact with Mcm10 and topoisomerase I.

What is the role of NETs in systemic lupus erythematosus?

Neutrophil extracellular traps (NETs) are released via a novel form of cell death called NETosis. NETs, consisting of a chromatin meshwork decorated with antimicrobial peptides, play an important role in the innate response to microbial infections. Clearance of NETs is impaired in a subset of patients with systemic lupus erythematosus, and NETosis is increased in these patients low-density granulocytes, a phenotype that correlates with disease activity. NETs are composed of secreted chromatin that may act as a source of autoantigens typical for SLE. NETs can directly damage tissues - including the endothelium - with implications for lupus nephritis and accelerated atherosclerosis.

Which acetylcholinesterase inhibitors are used for treatment of myasthenia gravis?

Pyridostigmine and neostygmine are acetylcholinesterase inhibitors that are used as first-line therapy for symptomatic treatment of myasthenia gravis. Pyridostigmine is the most widely used acetylcholinesterase inhibitor. Extended release pyridotsygmine and novel acetylcholinesterase inhibitors inhibitors with oral antisense oligonucleotides are being studied.

Αre plants from the genus Strychnos the original source of curare?

Species of plants from the genus Strychnos are the source of curare.

Which clinical trials for psoriasis involved tofacitinib? (November 2017)

Four phase 3 clinical trials have been performed to assess tofacitinib in psoriasis patients: OPT Retreatment, OPT Pivotal 1, OPT Pivotal 2, OPT Compare

Are patients with marfan syndrome at increased risk of arrhythmias?

Patients with marfan syndrome carry increased risk for arrhythmias

Have Quantitative Trait Loci affecting splicing (splicing QTLs) been linked to disease?

Yes, mutations in the DNA that affect the splicing pattern of genes have been linked in transcriptome population studies to a number of diseases.

What is Fuchs' Uveitis?

Fuchs' Uveitis (FU) is a chronic, low-grade-inflammatory disorder, involving anterior uvea and vitreous. Fuchs uveitis (FU) is a frequent, chronic course of intraocular inflammation, which is associated with a gradual onset of decreased visual acuity.

How does condensin affect the function of topoisomeraseII?

Condensin prevents deleterious anaphase bridges during chromosome segregation by promoting sister chromatid decatenation.

Which is the most common genetic lesion among patients with Joubert Syndrome and a cerebello-oculo-renal phenotype?

Joubert syndrome (JBTS) is an inherited ciliopathy giving rise to NPHP with cerebellar vermis aplasia and retinal degeneration. Among patients with JBTS and a cerebello-oculo-renal phenotype, mutations in CEP290 (NPHP6) are the most common genetic lesion.

Does HuR protein regulate the splicing process?

HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA

What type of data does the UK biobank resource contain?

The UK Biobank contains deep phenotyping and genomic data. A rich variety of phenotypic and health-related information is available on each participant, including biological measurements, lifestyle indicators, biomarkers in blood and urine, and imaging of the body and brain. Follow-up information is provided by linking health and medical records. Genome-wide genotype data have been collected on all participants, providing many opportunities for the discovery of new genetic associations and the genetic bases of complex traits.

Between which probes does the recurrent translocation breakpoint on chromosome 22 of neuroepithelioma lie?

The recurrent translocation breakpoint on chromosome 22 of neuroepithelioma has been localized between two probes, D22S1 and D22S15, by both in situ hybridization and somatic cell hybrids

Is Solanezumab effective for Alzheimer's Disease?

No. Solanezumab, a humanized monoclonal antibody that binds amyloid, failed to improve cognition or functional ability in patients with Alzheimer's Disease.

Which diseases can be treated with Itepekimab?

Itepekimab, a monoclonal antibody targeting IL-33, demonstrated clinical activity in asthma, with potential in chronic obstructive pulmonary disease (COPD).

What is the role of fucokinase?

FUK encodes fucokinase, the only enzyme capable of converting L-fucose to fucose-1-phosphate, which will ultimately be used for synthesizing GDP-fucose, the donor substrate for all fucosyltransferases.

Is Mediator present at super enhancers?

Yes. Super enhancers are clusters of enhancers that are densely occupied by the master regulator and mediator.

What is the active ingredient in the most common hand sanitizer?

Evaluation of a benzalkonium chloride hand sanitizer in reducing transient Staphylococcus aureus bacterial skin contamination in health care workers.

What is the association of Disease-Associated STRs (daSTRs) with domain boundaries?

Nearly all disease-associated STRs (daSTRs) are located at boundaries demarcating 3D chromatin domains. For instance, Fragile X syndrome patients exhibit severe boundary disruption in a manner that correlates with local loss of CTCF occupancy and the degree of FMR1 silencing.

What effect does azeliragon have on RAGE?

Azeliragon is an inhibitor of receptor for advanced glycation end products (RAGE).

What is the effect that EZH2 has on chromatin?

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms

What is liquid liquid phase transition?

The influence of membrane-free microcompartments resulting from crowding-induced liquid/liquid phase separation (LLPS) on the dynamic spatial organization of FtsZ, the main component of the bacterial division machinery, has been studied using several LLPS systems.

Can cffDNA be used for non-invasive testing?

Yes, cell-free fetal DNA (cffDNA) has made non-invasive prenatal testing possible.

Is durvalumab used for lung cancer treatment?

Yes, Durvalumab is an anti-PDL-1 antibody that is used for treatment of non-small-cell lung cancer.

Mutation of which gene is implicated in the Christianson syndrome?

Christianson syndrome is caused by mutations in SLC9A6 and is characterized by severe intellectual disability, absent speech, microcephaly, ataxia, seizures, and behavioral abnormalities.

What is the role of TRH in hypertension?

TRH gene overexpression induces hypertension in normal rats and spontaneously hypertensive rats have central TRH hyperactivity with increased TRH synthesis and release and an elevated TRH receptor number. TRH antisense treatment reduces hypertension. central TRH participates in the hypertension induced by body weight gain probably through its well-known action on sympathetic activity. the pressor effect of intravenous TRH is mediated primarily by a stimulation of alpha-adrenergic receptors. Activation of cardiac beta-adrenoceptors seems to contribute to the blood pressure increasing effect of intravenous TRH. Ang II system is involved in the TRH cardiovascular effects. Polymorphisms in TRH (thyrotropin-releasing hormone) are significantly associated with both blood pressure variation and hypertension. TRH may mediate the central leptin-induced hypertension effect A parallel increase in the density of brain TRH receptors with elevation of blood pressure has been shown and suggests that brain TRH receptors may play an important role in the pathophysiology of hypertension. TRH Receptor gene participates in the etiopathogenesis of essential hypertension.

Is phospholipid hydroperoxide glutathione peroxidase a selenoprotein?

Yes, the phospholipid hydroperoxide glutathione peroxidase (PHGPx/GPx4) is the major selenoprotein.

Which databases exist for experimentally determined topologies of α-helical transmembrane proteins ?

ExTopoDB and TMPDB.

Is protein M3/6 a dual specificity phosphatase?

M3/6 (DUSP8) is a dual-specificity phosphatase implicated in the dephosphorylation and inactivation of JNK and, to a lesser extent, p38 MAPKs.

Can cognitive behavioral therapy improve fatigue in cancer patients?

Yes, it has been documented that cognitive behavioral therapy reduces fatigue symptom severity in cancer patients. In addition, cognitive behavioral therapy has been also shown to improve mood and overall quality of life, and it can be successfully delivered through a variety of treatment modalities in patients with cancer.

What causes the "worst headache" of a patient's life?

This is a classic description of a subarachnoid hemorrhage (SAH). The gold standard for the diagnostic evaluation of a SAH remains non-contrast head computed tomography (CT) followed by lumbar puncture if the CT is negative.

What does the Smith–Waterman algorithm do?

The Smith-Waterman algorithm performs local sequence alignments.

DX-88 is investigational name of which drug?

DX-88 is investigational name of a drug Ecallantide, a 60-amino acid recombinant protein discovered through phage display technology, that is a highly specific, potent inhibitor of human plasma kallikrein that has been used successfully in the treatment of patients experiencing acute hereditary angioedema attacks.

Which is the database of molecular recognition features in membrane proteins?

mpMoRFsDB provides valuable information related to disorder-based protein-protein interactions in membrane proteins.

What are the generic versions of Viagra?

Generic versions of sildenafil are Elonza, Caverta, Zenegra-100, Vega Asia, Suhagra-100, Vega, Revatio.

What is the function of a chaperonin?

Molecular chaperones promote the correct folding of proteins in aggregation-prone cellular environments by stabilizing nascent polypeptide chains and providing appropriate folding conditions. They are involved in the development of pathological processes, including--atherosclerosis and coronary heart disease.

What is BEL(Biological Expression Language) used for?

Biological Expression Language (BEL) is a novel method for the statistical extraction of causal relation relationships from large biomedical literature datasets.

Is the number of described human nuclear mutations less than 50000?

No, The number of known mutations in human nuclear genes, underlying or associated with human inherited disease, has now exceeded 100,000 in more than 3700 different genes (Human Gene Mutation Database).

What is the molecular pathogenesis of Spinal Muscular Atrophy?

Spinal muscular atrophy is an autosomal recessive neurodegenerative disease characterised by degeneration of spinal cord motor neurons, atrophy of skeletal muscles, and generalised weakness. It is caused by homozygous disruption of the survival motor neuron 1 (SMN1) gene by deletion, conversion, or mutation, resulting in downregulated biogenesis of uridine-rich small nuclear RNAs (U snRNAs), which are major components of the splicing machinery.

What is Invaplex 50?

The Shigella flexneri Invaplex 50 is a macromolecular complex containing IpaB, IpaC, and LPS, formulated from an aqueous extract of virulent Shigella delivered via nasal administration. It is used against shigellosis, a leading cause of diarrhea worldwide. The Invaplex 50 nasal vaccine was safe with encouraging mucosal immune responses.

Is cytisine superior to nicotine replacement therapy for smoking cessation?

Yes, one clinical trial that directly compared smoking cessation rates with cytisine versus nicotine replacement therapy reported that cytisine was superior to nicotine-replacement therapy in helping smokers quit smoking, but it was associated with a higher frequency of self-reported adverse events.

Which company produces ORMD-0801?

ORMD-0801 is produced by Oramed Pharmaceuticals.

Which receptor does GDF15 bind?

GDF15 binds specifically to GDNF family receptor α-like (GFRAL)

Is periampullary carcinoma (PAC) a relatively rare genitourinary malignancy

Periampullary carcinoma (PAC) a relatively rare gastrointestinal malignancy and includes Pancreaticobiliary as a subtype of Periampullary carcinoma

What is the origin of human breast milk bacteria?

It is believed that certain bacteria from the maternal gastrointestinal tract could translocate through a mechanism involving mononuclear immune cells, migrate to the mammary glands via an endogenous cellular route (the bacterial entero-mammary pathway), and subsequently colonize the gastrointestinal tract of the breast-fed neonate

What is Legg-Calvé-Perthes Disease

Legg-Calve-Perthes disease is idiopathic avascular necrosis of the hip, usually occurring in pediatric populations.

Which histone modifications are correlated with transcription elongation?

This is accompanied by reductions in the level of H3K36 trimethylation, a posttranslational histone modification associated with efficient transcriptional elongation, and the number of full-length transcripts from these genes. The 3' ZNF exons contain H3K36me3, a mark of transcriptional elongation.

List five proteins with antioxidant properties?

thioredoxin 1 (Trx1), peroxiredoxin 1 (Prx1), GSH reductase (GSR), phosphatase and tensin homolog (PTEN) superoxide dismutase (SOD)

The secreted frizzled-related protein 3 (sFPR3) is altered in human cancers. Are its level found to increase or to decrease?

SFRPs are down-regulated in several cancers and this is often correlated with poor prognosis, as has been shown for breast, colorectal, and a number of other cancers. (PMID: 21494614) We performed tissue microarray and found that the level of sFRP3 protein was high in normal kidney, low in primary renal cancer tissues, and high in metastatic renal cancer tissues. (PMID: 20160027)

How does dronedarone affect thyroid hormone signaling in the heart?

Dronedarone via its metabolite debutyldronedarone acts as a TRalpha(1)-selective inhibitor and selectively mimicks hypothyroidism. Dronedarone decreases TRalpha 1 and beta 1 expression by about 50% in the right atrium (RA) while in the left ventricle, only TRbeta1 is found to be decreased.

Albumin depletion is a common first step for proteomic analysis of CSF fluid. What is the advantage and disadvantage of this procedure?

Depletion of the high abundant protein Albumin from CSF samples is improving the detection of lower abundant proteins but may also lead to the potential loss of non-target proteins.

Can secondary glioblastoma be caused by brain irradiation?

Yes, brain irradiation can cause secondary glioblastoma.

What is the relationship between TailorX and Oncotype?

The TAILORx trial uses the Oncotype DX recurrence score to assign estrogen receptor-positive (ER+), node-negative patients to chemotherapy plus hormonal therapy versus hormonal therapy alone.

Is Nanog repressed in pluripotent stem cells?

The homeobox gene Nanog is a key intrinsic determinant of self renewal in embryonic stem (ES) cells, and its repression leads ES cells to selectively differentiate into primitive endoderm.

Which genes are associated with Epidermolysis Bullosa Simplex?

In one family studied, inheritance of EBS is linked to the gene encoding keratin 14

Are cutaneous porphyrias inherited with a recessive pattern?

No, cutaneous porphyrias are inherited in a dominant (not recessive) pattern.

Which RNA polymerase is used for the replication of viroids?

DNA-dependent RNA polymerase II of plant origin transcribes viroid RNA into full-length copies

What is known about PAI-1 in longevity in humans?

Plasminogen activator inhibitor-1 (PAI-1) has been shown to be a key component of the senescence-related secretome and a direct mediator of cellular senescence. In murine models of accelerated aging, genetic deficiency and targeted inhibition of PAI-1 protect against aging-like pathology and prolong life span. However, the role of PAI-1 in human longevity remains unclear. , in centenarians there was a significantly higher frequency of the 4G allele and of the homozygous 4G4G genotype associated with high PAI-1 levels. Since high PAI-1 is considered a predictor of recurrent myocardial infarction in young men, it is intriguing that the corresponding genetic marker is more frequent in centenarians who have escaped major age-related atherothrombotic disease and reached the extreme limits of human life. Homozygosity for the 4G allele, despite its association with impaired fibrinolysis, is compatible with successful aging.

List angiotensin-converting-enzyme inhibitors.

captopril enalapril lisinopril ramipril

Which are the best methods for the prediction of circular RNA (circRNA)?

A circRNA prediction software for plants . Circular RNA profile in gliomas revealed by identification tool UROBORUS. Numerous algorithms that are used to detect genome-wide circRNA expression from RNA sequencing data have been developed in the past few years, but there is little overlap in their predictions and no clear gold-standard method to assess the accuracy of these algorithms. MiARma-Seq: a comprehensive tool for miRNA, mRNA and circRNA analysis. Here, we use common RNAseq datasets to scrutinize and compare the output from five different algorithms; circRNA_finder, find_circ, CIRCexplorer, CIRI, and MapSplice and evaluate the levels of bona fide and false positive circRNAs based on RNase R resistance.

What is the mode of inheritance of Facioscapulohumeral muscular dystrophy (FSHD)?

Facioscapulohumeral muscular dystrophy has an autosomal dominant inheritance pattern.

What is the benserazide's mechanism of function when co-administered with L-DOPA in patients with Parkinson's Disease?

Benserazide is a peripheral decarboxylase inhibitor. Benserazide in combination with L-DOPA constitutes a slow-release formulation of L-DOPA in patients with Parkinson's disease (PD), it reduces peaks and rapid fluctuations of L-DOPA plasma levels (possibly responsible for peak-dose dyskinesias and end-of-dose deterioration) and considered as the best available therapy.

Which DNA repair system is involved in HNPCC?

In HNPCC families, germline mutations in any of four genes encoding proteins of a specialized DNA repair system, the mismatch repair, predispose to cancer development.

Has the Spanich flu virus been reconstructed?

Tes, Reconstruction of the 1918 influenza virus has facilitated considerable advancements in our understanding of this extraordinary pandemic virus.

What are some of the effects of Zika Virus in infected individuals?

While most of the symptoms of zika virus are relatively mild, zika virus in pregnant mothers can cause microcephaly and other congenital defects in the fetus.

Which bioconductor tool has been developed for accessing bacterial regulatory networks?

The Regutools R package to facilitates programmatic access to RegulonDB data in computational biology. regutools gives researchers the possibility of writing reproducible workflows with automated queries to RegulonDB. The regutools package serves as a bridge between RegulonDB data and the Bioconductor ecosystem by reusing the data structures and statistical methods powered by other Bioconductor packages.

Which neuropsychiatric disorders are associated with 16p13.11 genomic copy number variants?

schizophrenia, autism, mental retardation, ADHD, epilepsy

What is the protective efficacy of vaxchora against moderate to severe cholera?

The protective efficacy of vaxchora against moderate to severe cholera is 80-100%.

List off label uses for Rituximab.

Off label uses for rituximab are for poly- and dermatomyositis, multiple sclerosis, immune thrombocytopenia, systemic lupus erythematosus (SLE), lupus nephritis (LN), and other immune diseases.

Which is the main regulatory molecule of SERCA2A function in the cardiac muscle?

SERCA2a activity is regulated by phosphorylation of another SR protein, Phospholamban (PLN). Phospholamban (PLB) inhibits the activity of SERCA2a, the Ca(2+)-ATPase in cardiac sarcoplasmic reticulum, by decreasing the apparent affinity of the enzyme for Ca(2+).

What are the computational tools for the prediction of beta-barrel transmembrane proteins?

The computational tools for the prediction of beta-barrel transmembrane proteins (TMBs) are based mainly on the following methodologies: Hidden Markov Models (HMMs), hydrophobicity, structural data, k-nearest neighbor algorithm, Neural Networks and Support Vector Machines. The state-of-the-art computational tools for the prediction of TMBs are: BETAWARE, BOCTOPUS, BOMP, BTMX, HMM-B2TMR, OMPdb,PRED-TMBB, PROB, ProfTMB, PV, TMBETA-NET, TMB finding pipeline, TMBETADISC-RBF, TMBETAPRED-RBF, TMBHMM, TMB-Hunt, TMB-Hunt2, TMBKNN, TMBpro, transFold.

Has intepirdine been evaluated in clinical trials? (November 2017)

Yes, intepirdine was in Phase III clinical trials in November 2017.

What is the results of mutations in the gene autoimmune regulator?

Autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a primary immunodeficiency caused by mutations in the autoimmune regulator gene (AIRE)

What is the SLC25A20 protein transporting?

The carnitine/acylcarnitine transporter (CACT; SLC25A20) mediates an antiport reaction allowing entry of acyl moieties in the form of acylcarnitines into the mitochondrial matrix and exit of free carnitine.

Has single guide RNA been used on human cells?

Yes, sgRNA has been used in human cell lines.

Can therapeutic levels of Vedolizumab be found in the breast milk of nursing mothers following treatment for Inflammatory bowel disease?

vedolizumab can be detected in the breast milk of nursing mothers. although more data are imperative, the concentrations of vedolizumab in breast milk are minute and are therefore unlikely to result in systemic or gastro-intestinal immune-suppression of the infant.

What is the "wearing-off" phenomenon in levodopa-treated patients with Parkinson's Disease?

Chronic administration of traditional levodopa/dopa decarboxylase inhibitor formulations to Paskinson's Disease patients is associated with the development of complications, such as wearing-off phenomenon. Wearing-off phenomenon is characterized by the predictable emergence of motor symptoms (e.g. rigidity and freezing) and nonmotor PD symptoms (e.g. anxiety and shortness of breath), before the next scheduled dose of medication.

What are the indications for treatment with anti-hepcidin?

improving anemia control anemia management in hemodialysis iron-restricted anemias

Describe CrossICC

CrossICC is an R package designed for the unsupervised clustering of gene expression data from multiple datasets/platforms without the requirement of batch effect adjustment. CrossICC utilizes an iterative strategy to derive the optimal gene signature and cluster numbers from a consensus similarity matrix generated by consensus clustering.

What is the application of the Bimolecular Fluorescence Complementation (BiFC) assay in Drosophila embryos?

Bimolecular fluorescence complementation (BiFC) is a powerful method for studying protein-protein interactions in different cell types and organisms. This method was recently developed in the fruit fly Drosophila melanogaster, allowing analyzing protein interaction properties in a physiologically relevant developing context.