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Enelpol 10

What is STATegra?

STATegra is a comprehensive multi-omics dataset of B-cell differentiation in mouse. It includes measurements from up to 10 different omics technologies applied to the same biological system, namely the well-studied mouse pre-B-cell differentiation.

Can gas vesicles be detected by ultrasound?

Gas vesicles have been identified as nanoscale reporters for ultrasound.

What is the association between h-index and academic rank in academic neurosurgery?

Greater h-index is associated with greater academic rank in academic neurosurgery. The h indices increased significantly with increasing academic rank, with the median for instructors, assistant professors, associate professors, and professors was shown to be 2, 5, 10, and 19, respectively. In addition, h-index was shown to be predictive of NIH funding, fellowship training, academic productivity and salary.

Are mutations in the nf1 gene associated with memory?

Yes, distinct functional domains of neurofibromatosis type 1 regulate immediate versus long-term memory formation.

What is caused by a gain-of-function mutation in CLCN2?

A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism, which is the most common and curable form of arterial hypertension.

What is a decoy exosome?

exosomes display a large repertoire of tumor antigens that induce autoantibodies and exert a decoy function against complement-mediated cytotoxicity.

Does Curare function by stimulating the acetylcholine receptor?

No. Curare function does not stimulate the acetylcholine receptor.

What is known about type D personality trait in cancer patients?

Reported prevalence rates of type D personality ranges from 19% to 22% in patients with cancer. In patients with cancer, Type D personality is associated with poor quality of life and mental health. Cancer patients with a Type D personality as compared with non-Type D patients perceive that they receive less information, report less satisfaction with the amount of received information, believe that their illness has significantly more serious consequences, will last significantly longer, and experience significantly more symptoms that they attribute to their illness. Also, they are more concerned about their illness, and their disease more often influences them emotionally. Also, Type D cancer patients are at an increased risk for comorbidity burden and increased health care utilization.

What are the effects of BMAL1 deficiency?

BMAL1 deficiency is associated with premature aging and reduced lifespan and BMAL1 deficiency leads to development of stress induced senescence in vivo. Down-regulation of Bmal1 also accelerates the development of tumours, adipogenesis.

Can non ubiquitinated Tomm20 promote mitophagy?

The translocase of outer mitochondrial membrane 20 (Tomm20), is a mitochondrial translocase that, when ubiquitinated, promotes mitophagy.

Which R package has been developed for MS-based label-free phosphoproteomics?

Phosphonormalizer is an R package for normalization of MS-based label-free phosphoproteomics.

List GATA-1 interacting partners as discovered with the help of the biotinylation tagging approach.

Our work describes, for the first time, distinct GATA-1 interactions with the essential hematopoietic factor Gfi-1b, the repressive MeCP1 complex, and the chromatin remodeling ACF/WCRF complex, in addition to the known GATA-1/FOG-1 and GATA-1/TAL-1 complexes

List available circular RNA prediction tools.

circRNA_finder, find_circ, CIRCexplorer, CIRI, and MapSplice.

What is the mode of action for Tocilizumab?

Tocilizumab (TCZ) is a recombinant humanized monoclonal antibody against the IL-6 receptor and has been approved in many countries, including the United States, for the treatment of moderate to severe RA in patients who have not adequately responded to one or more disease-modifying antirheumatic drugs

Where is the protein protamine 2 expressed?

Human sperm express two types of protamine: protamine 1 (P1) and the family of protamine 2 (P2) proteins.

What is LHON, also known as Lebers syndrome?

Leber's hereditary optic neuropathy (LHON) is a common inherited mitochondrial disorder that is characterized by the degeneration of the optic nerves, leading to vision loss.

What is hemolacria?

Hemolacria is a rare phenomenon of bloody tears caused by various ocular and systemic conditions, as well as psychological, pharmacologic, and idiopathic etiologies.

Is there a role for CADM1 in Myelodysplastic syndrome (MDS)?

Yes, CADM1 may be important in the physiopathology of the del(11q) MDS, extending its role as tumor-suppressor gene from solid tumors to hematopoietic malignancies with deletion of the long arm of chromosome 11.

What is Sotos syndrome?

Sotos syndrome is a well-known overgrowth syndrome characterized by excessive growth during childhood, macrocephaly, distinctive facial appearance and learning disability

Which type of cells protect Haematopoietic stem and progenitor cells (HSPCs) from ultraviolet-light-induced DNA damage in aquatic vertebrates?

Haematopoietic stem and progenitor cells (HSPCs) require a specific microenvironment to grow and are protected from ultraviolet-light-induced DNA damages by melanocytes. Mutations that lack melanocytes have normal steady-state haem atopoiesis under standard laboratory conditions while melanocytes above the stem cell niche protect HSPCs against ultraviolet- light-induced damage.

Does MicroRNA-21 (miR-21) contribute to cardiovascular disease?

MicroRNA-21 (miR-21) is a highly expressed microRNA (miRNA) in cardiovascular system. Recent studies have revealed that its expression is deregulated in heart and vasculature under cardiovascular disease conditions such as proliferative vascular disease, cardiac hypertrophy and heart failure, and ischemic heart disease. miR-21 is found to play important roles in vascular smooth muscle cell proliferation and apoptosis, cardiac cell growth and death, and cardiac fibroblast functions. Accordingly, miR-21 is proven to be involved in the pathogenesis of the above-mentioned cardiovascular diseases as demonstrated by both loss-of-function and gain-of-function approaches

Belzutifan has shown effectiveness for which diseases?

Belzutifan is the small-molecule HIF 2 alpha inhibitor that has demonstrated significant efficacy in the von Hippel-Lindau disease related renal cell carcinomas, hemangioblastomas, and pancreatic neuroendocrine tumors while demonstrating an acceptable safety profile

Does BNP increase after intensive exercise in athletes?

BNP and NTproBNP increase early after exercise in healthy athletes performing different types of sports. It is unknown the reason of this increase. The transient increases in BNP, NT-pro-BNP and troponin T are more likely to reflect myocardial stunning than cardiomyocyte damage.

Which are the genes responsible for Dyskeratosis Congenita?

To date, 8 genes have been associated with Dyskeratosis Congenita development. These are DKC1, TERC, TERT, NOP10, NHP2, TIN2, C16orf57, and TCAB1. Seven of these are important in telomere maintenance, because either they encode components of the telomerase enzyme complex (DKC1, TERC, TERT, NOP10, NHP2, and TCAB1) or the shelterin complex (TINF2).

Which are the biotracers used for detection of Alzheimer's disease using PET?

Pittsburgh compound B (PIB) was the first radiotracer capable of highlighting deposits of beta-amyloid—one pathological hallmark of Alzheimer's disease—in living individuals during a PET scan. The Alzheimer's Association helped fund early PIB development. The Association in 2006 also awarded a $2.1 million grant to the Alzheimer's Disease Neuroimaging Initiative (ADNI) to expand this long-term, nationwide study to include PIB-PET imaging. 18F flutemetamol (flute), another radiotracer that highlights beta-amyloid in a PET scan, is structurally identical to PIB except for one fluorine atom in place of a carbon atom. That small chemical change enables flutemetamol to remain stable significantly longer than does PIB, potentially increasing its usefulness outside research settings. In phase II study results reported in the Annals of Neurology, flutemetamol performed similarly to PIB. Additional testing is under way. Florbetapir F 18 (18F-AV-45) is also a radiotracer that highlights brain beta-amyloid during a PET scan. At the 2010 Alzheimer's Association International Conference on Alzheimer's Disease (AAICAD), florbetapir's developer first reported data, later published in the JAMA, showing nearly perfect correlation between brain amyloid levels detected by florbetapir PET scans in study volunteers and levels found in autopsies of the same individuals a few months later. The developer has sought Food and Drug Administration (FDA) approval to market florbetapir under the brand name Amyvid. The FDA has said it will withhold approval until the developer establishes a professional training program to ensure accuracy and consistency in reading and interpreting Amyvid scans. Florbetaben (BAY 94-9172) is another radiotracer designed to detect beta-amyloid during a PET scan. Phase II study results and other florbetaben data were reported at the 2010 Alzheimer's Association International Conference on Alzheimer's Disease (AAICAD). Phase II data were also later published in Lancet Neurology. Further studies are now under way.

What types of DNA mutations are induced by 2-hydroxy-dATP (2-OH-dATP)?

2-hydroxy-dATP mainly elicits G:C --> A:T transitions, and, to a lesser extent, G:C --> T:A transversions The induction of G:C --> T:A transversions by 2-OH-dATP indicates the formation of G*2-OH-dATP pairs. 2-OH-dATP also induces tandem (CC --> TT) mutations. Altogether, 2-OH-dATP induces both transition and transvertion mutations, such as A:T --> G:C, A:T --> C:G and G:C --> T:A mutations.

Is Erythropoietin effective for neuroprotection of Preterm Infants.

No. High-dose erythropoietin treatment administered to extremely preterm infants from 24 hours after birth through 32 weeks of postmenstrual age did not result in a lower risk of severe neurodevelopmental impairment or death at 2 years of age.

What brain procedure can be done using the NeuroBlate system?

NeuroBlate System is used for Laser interstitial thermal therapy.

Which drugs are included in the FEC-75 regimen?

Fluorouracil, epirubicin, and cyclophosphamide are included in the FEC-75 regimen. This chemotherapy regiment is used for breast cancer treatment.

What is the most sensitive test for the diagnosis of multiple sclerosis?

These results support previous conclusions that MRI is the most sensitive test for detecting white matter asymptomatic lesions, and the most predictive for the diagnosis of CDMS.

What does RUNX2 stand for?

Runt related factor-2

What is the role of chromomethylases in plants?

Chromomethylases (CMTs), which constitute a plant-specific DNA (cytosine-5)-methyltransferase family, are involved primarily in the maintenance of symmetrical CpNpG (N = A, T, C, or G) methylation and they also play a role in de novo methylation. CMTs are characterized by the presence of a chromatin-associated domain (chromodomain) inserted within the catalytic protein motifs I and IV. CMTs have likely evolved because of the high levels of CpNpG methylation present in plant genomes relative to animal genomes. The targeting of CMT methylation is accomplished by short interfering RNA (siRNA) pathways and histone methylation (H3K9, H3K27). It has been shown that transposons are in vivo targets of CMT-dependent methylation, suggesting that CMTs play a role in the plant genome surveillance. In Arabidopsis, CMTs play a key role in egg cell reprogramming and normal embryogenesis during the first few divisions of the zygote by mediating transposon and euchromatin epigenetic gene silencing. In tomatoes, CMTs are preferentially expressed in the pericarp during fruit development which suggests involvement of CMTs in the locus-specific control of methylation in the pericarp during fruit growth.

Was golimumab tested for diabetes?

Yes, among children and young adults with newly diagnosed overt type 1 diabetes, golimumab resulted in better endogenous insulin production and less exogenous insulin use than placebo.

What is the role of edaravone in traumatic brain injury?

Edaravone, a free radical scavenger, has been shown to have neuroprotective effects after traumatic brain injury. In animal models, edaravone has been shown to reduce neuronal damage by scavenging reactive oxygen species (ROS), maintain intact the autoregulation of the cerebral vasculature, decrease neuronal loss, reduce programmed cell death, the presence of inflammatory cytokines, cerebral edema, and blood-brain barrier (BBB) permeability. Edaravone also protects against neurological deficits and memory deficits following traumatic brain injury.

What is the Her2 status in Li-Fraumeni syndrome?

In the background of a germline TP53 mutation of the Li-Fraumeni syndrome, the Her2 status was found to be positive in 63-83% of the cases.

Which application is the backbone of BioPAXViz?

BioPAXViz is a Cytoscape (version 3) application, providing a comprehensive framework for metabolic pathway visualization. Beyond the basic parsing, viewing and browsing roles, the main novel function that BioPAZViz provides is a visual comparative analysis of metabolic pathway topologies across pre-computed pathway phylogenomic profiles given a species phylogeny.

Are there small molecule CGRPs under development for the treatment of migraine?

Yes, there are several small molecule CGRPs under development for the treatment of migraine.

Is BNN20 involved in Parkinson's disease?

Yes. Neurotrophic factors are among the most promising treatments aiming at slowing or stopping and even reversing Parkinson's disease (PD). BNN-20 has been suggested as an important neuroprotective agent acting through the TrkB neurotrophin receptor pathway, mimicking the action of the endogenous neurotrophin BDNF. Thus BNN-20 could be proposed for treatment of PD.

Has LB-100 been tested in clinical trials?

Yes, a phase I trial has been performed to assess the safety, tolerability, and potential activity of LB-100, a first-in-class small-molecule inhibitor of protein phosphatase 2A (PP2A) in adult patients with progressive solid tumors.

What is "enhancer hijacking"?

Enhancer hijacking is the molecular process through which a structural variant removes or moves a TAD boundary to expose TSSs to regulatory enhancers from which they would normally be insulated.

Can beans induce apoptosis?

White kidney bean lectin has been shown to exert anti-proliferative and apoptotic effects on cancer cells

What is promoted by ERAP1-ERAP2 dimerization?

ERAP1-ERAP2 dimerization increases peptide-trimming efficiency.

List functional roles of the FtsZ protein.

Four major roles of FtsZ have been characterized: cell elongation, GTPase, cell division, and bacterial cytoskeleton.

What is known about ROS production in relation to UVR?

Skin exposure to ultraviolet radiation (UVR) may induce the production of reactive oxygen species (ROS) which cause oxidative stress, DNA damage, and alteration of fibroblasts and collagen responsible for skin photoaging.

Is there an association between Klinefelter syndrome and breast cancer?

Yes, Klinefelter syndrome is associated with increased risk of male breast cancer. Other risk factors of male breast cancer are positive family history, and mutations in BRCA1 and specially BRCA2.

Please list 7 classes of drugs that interact with Warfarin.

The number of drugs reported to interact with warfarin continues to expand. There are reports of interactions with azole antibiotics, macrolides, quinolones, nonsteroidal anti-inflammatory drugs, including selective cyclooxygenase-2 inhibitors, selective serotonin reuptake inhibitors, omeprazole, lipid-lowering agents, protease inhibitors, amiodarone, fluorouracil, psychotropics, and oral corticosteroids.

Please list the difference between Pyoderma gangrenosum versus chronic venous ulceration?

Even when other body sites are affected, pyoderma gangrenosum usually affects the upper and lower legs and feet or peristomal sites compared with chronic venous ulcers that are limited to the lower legs and feet. (2) Pyoderma gangrenosum can be associated with systemic diseases, especially inflammatory bowel disease. (4) Crater-like holes or cribriform scarring is commonly seen in pyoderma gangrenosum but not in chronic venous ulcers.

What is the association of estrogen replacement therapy and intracranial meningioma risk?

The association between hormone replacement therapy and meningioma risk is controversial. Increased risk of meningioma was demonstrated in estrogen-only hormonal replacement therapy. However, other studies did not find an association between hormonal replacement therapy and meningioma risk.

Does Estrogen lead to forkhead FoxA1 activation?

The pioneer transcription factor FoxA1 plays an important role in estrogen signaling by opening closed chromatin and promoting recruitment of the estrogen receptor to its target regions in DNA.

List RNA modifications databases

RMBase and MODOMICS

Can RNAPolII function as an RNA-dependent RNA-polymerase?

RNA polymerase II (Pol II) is a well-characterized DNA-dependent RNA polymerase, which has also been reported to have RNA-dependent RNA polymerase (RdRP) activity. Pol II can use a homopolymeric RNA template, can extend RNA by several nucleotides in the absence of DNA, and has been implicated in the replication of the RNA genomes of hepatitis delta virus (HDV) and plant viroids. The RdRP activity of Pol II provides a missing link in molecular evolution, because it suggests that Pol II evolved from an ancient replicase that duplicated RNA genomes.

Which tool has been developed for microRNA-target enrichment and network-based analysis?

MIENTURNET (MicroRNA ENrichment TURned NETwork) is a web tool that receives in input a list of miRNAs or mRNAs and tackles the problem of prioritizing miRNA-target interactions by performing a statistical analysis followed by a fully featured network-based visualization and analysis. The statistics is used to assess the significance of an over-representation of miRNA-target interactions and then MIENTURNET filters based on the statistical significance associated with each miRNA-target interaction. In addition, the holistic approach of the network theory is used to infer possible evidences of miRNA regulation by capturing emergent properties of the miRNA-target regulatory network that would be not evident through a pairwise analysis of the individual components.

List Cdk targets that are dephosphorylated during cytokinesis

Aip1, Ede1 and Inn1 are Cdk targets that are dephosphorylated during cytokinesis.

Which is the relation between sweating and anaerobic threshold?

There is no clear evidence of the relationship between sweating and anaerobic threshold

What is the use of the Apfel Score?

The Apfel simplified risk score, developed in 1999, is the most widely used tool for risk stratification of postoperative nausea and vomiting.

Should istiratumab be used for Pancreatic Cancer?

No. In a clinical trial Istiratumab failed to improve the efficacy of standard of care chemotherapy in metastatic pancreatic cancer patients.

Which drugs are included in the Lonsurf pill?

Lunsurf pill includes trifluridine and tipiracil. It is a novel form of chemotherapy for metastatic colorectal cancer.

List some ways to reverse Tau hyperphosphorylation in Tauopathies?

Different ways have been used to try to reverse Tau hyperphosphorylation through administration of inhibitors such as: 7-nitroindazole, memantine, glycogen synthase kinase-3 inhibitors. Other approaches are transplantation of Human umbilical cord blood-derived mesenchymal stem cells and administration of M1 muscarinic agonists.

Which domain of TIA-1 is necessary for stress granule assembly?

TIA-1 is an RNA binding protein that promotes the assembly of stress granules (SGs), discrete cytoplasmic inclusions into which stalled translation initiation complexes are dynamically recruited in cells subjected to environmental stress. The RNA recognition motifs of TIA-1 are linked to a glutamine-rich prion-related domain (PRD). Truncation mutants lacking the PRD domain do not induce spontaneous SGs and are not recruited to arsenite-induced SGs, whereas the PRD forms aggregates that are recruited to SGs in low-level-expressing cells but prevent SG assembly in high-level-expressing cells.

What forms part of the senescence associated secretory phenotype, or SASP?

The diverse arrays of proteins secreted by senescent cells have been described to influence aging and to have both pro-tumorigenic and anti-tumorigenic influences on the surrounding microenvironment. Further characterization of these proteins, known as the senescence-associated secretory phenotype (SASP), and their regulators is required to understand and further manipulate such activities. The senescence-associated secretory phenotype (SASP) is characterized by IL1B, CXCL8, CCL2, TNF, CCL27 and other pro-inflammatory factors including a novel SASP component CLEC11A.

Is there evidence that tomato juice lowers cholesterol levels?

Yes, there is evidence to suggest that tomato juice (and other tomato products) can decrease cholesterol concentrations. It was shown that tomatoes inhibit cholesterol biosynthesis.

Which is the subcellular localization of the protein angiogenin?

Under growth conditions, ANG is located in nucleolus where it promotes ribosomal RNA (rRNA) transcription thereby stimulating cell growth. In adverse conditions, ANG is relocated to cytoplasm to promote damage repairs and cell survival.

What is the mode of action of Tetrocarcin-A?

The anti-tumor antibiotic, tetrocarcin A, directly induces apoptosis of human breast cancer cells.

What is the mechanism of action of idasanutlin?

Idasanutlin is a small-molecule inhibitor of MDM2, a negative regulator of tumor suppressor p53.

Which bacteria are enriched in the gut microbiome of infants following exposure to fury pets?

Pre- and postnatal pet exposure enriched the abundance of Oscillospira and/or Ruminococcus in infants.

Name three binding partners of cofilin 2.

Cofilin 2 can bind miR-201a, the protein 14-3-3, and ATP/ADP-Pi-actin filaments.

How do Hsp70 and Hsp110 affect mRNA stability?

Hsp70 and Hsp110 act as RNA-binding entities in vivo to guide the appropriate folding of RNA substrates for subsequent regulatory processes such as mRNA degradation and/or translation.

List the vaccine strains contained in Fluvirin.

Fluvirin contains 18 mg of haemagglutinin per H1N1 vaccine strain, 17 mg of haemagglutinin per H3N2 vaccine strain, and 15 mg of haemagglutinin per B vaccine strain.

Which company produces the Oncomine Dx target test?

The Oncomine Dx Target Test Panel is produced by Thermo Fisher Scientific.

Has proteomics been used in the study of Pick's disease?

Yes, proteomics has been used in the study of Pick's disease.

What is the target of the drug remdesivir?

remdesivir is a polymerase inhibitor

Is aggrephagy a variant of autophagy?

Yes, the selective branch of autophagy that deals with identification, capture and degradation of protein aggregates is called aggrephagy.

What is the triad of Melkersson-Rosenthal syndrome?

Melkersson-Rosenthal syndrome is an uncommon granulomatous disease characterized by the triad of relapsing facial paralysis, orofacial edema and fissured tongue.

Is Prochlorococcus the most abundant photosynthetic organism?

Yes, the marine cyanobacterium Prochlorococcus is the smallest and most abundant photosynthetic organism on Earth.

Which biological process takes place in nuclear speckles?

Speckles are subnuclear structures that are enriched in pre-messenger RNA splicing factors and are located in the interchromatin regions of the nucleoplasm of mammalian cells. They serve as splicing factor storage sites and play important roles in regulation of pre-mRNA splicing.

What is the target of Sutimlimab?

Sutimlimab is a novel humanized monoclonal antibody directed against classical pathway complement factor C1s.

List sodium glucose co-transporter-2 (SGLT2) inhibitors that have been FDA approved for type 2 diabetes mellitus treatment.

Canagliflozin, along with dapagliflozin and empagliflozin, are SGLT2 inhibitors approved by the US FDA for use in the treatment of type 2 diabetes.

What is ChiRP-seq (Chromatin Isolation by RNA Purification sequencing)?

ChiRP-seq (Chromatin Isolation by RNA Purification sequencing) is a method where tiling oligonucleotides retrieve specific lncRNAs with bound protein and DNA sequences, which are enumerated by deep sequencing. ChIRP-seq of three lncRNAs reveal that RNA occupancy sites in the genome are focal, sequence-specific, and numerous. ChIRP-seq is generally applicable to illuminate the intersection of RNA and chromatin with newfound precision genome wide.

Can TAD disruption lead to disease?

TAD boundaries are insulators of genomic neighborhoods. Τhe disruption of these structures by genomic rearrangements can result in gene misexpression and disease.

Which ones are the ESKAPE organisms?

The 6 ESKAPE pathogens are Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species.

List drugs included in the TRIUMEQ pill.

Triumeq is a single-tablet regimen for patients with HIV infection comprising dolutegravir, abacavir and lamivudine.

What is Desomorphine?

Desomorphine is an opioid misused as "crocodile", a cheaper alternative to heroin Desomorphine is the semi-synthetic opioid claimed to be the main component of krokodil

Could transcription factors act as cell-cell signalling molecules?

Yes. Recent data support the view that transcription factors - in particular, homeoproteins - can be transferred from cell to cell and have direct non-cell-autonomous (and therefore paracrine) activities.

What is the role of anhedonia in coronary disease patients?

Anhedonia is associated with poor prognosis in patients with coronary disease. Namely, in patients with coronary disease, anhedonia was associated with increased mortality, greater risk for major cardiac event, impaired physical health status, more cardiac symptoms, more feelings of disability. These associations were independent from clinical and demographic factors.

What is EpiMethylTag?

EpiMethylTag is a fast, low-input, low sequencing depth method, that combines ATAC-seq or ChIP-seq (M-ATAC or M-ChIP) with bisulfite conversion, to simultaneously examine accessibility/TF binding and methylation on the same DNA.

What is a HapMap

HapMap is a international effort for creating an annotated haplotype map of the world’s most commonhaplotype sequences.

Are seizures among the neurological symptoms of incontinentia pigmenti?

Incontinentia pigmenti is an X-linked dominant disorder resulting from a mutation of IKBKG. This disorder has a classic dermatologic presentation, but neurologic involvement, with seizures and cortical infarction, can arise shortly after birth.

What is the role of Acyl-Homoserine Lactone in bacteria?

A number of bacteria use a class of chemical compounds called acyl-homoserine lactones (AHLs) as quorum sensing (QS) signals to coordinate their behavior at the population level, including pathogens like Pseudomonas aeruginosa.

Which is the vector of Louping ill virus?

Louping ill virus (LIV) belongs to the mammalian tick-borne virus group of the genus Flavivirus which cause central nervous system disease. LIV infects the red grouse Lagopus lagopus scoticus, causing high mortality. LIV is transmitted by the tick Ixodes ricinus.

Does head ct increase brain tumor risk?

Yes, there appears to be a small but higher than expected lifetime risk of secondary brain tumors in persons who underwent CT scans during childhood.

Which are the most under-represented oligonucleotides in higher eukaryote genomes?

The oligonucleotides containing the CG and TA dinucleotide are generally under-represented in higher eukaryote genomes

What is the function of LOX proteins in the ECM?

Lysyl oxidases (LOX) are copper-dependent enzymes that oxidize primary amine substrates to reactive aldehydes. The best-studied role of LOX enzymes is the remodeling of the extracellular matrix (ECM) in animals by cross-linking collagens and elastin

What is the use of pegcetacoplan?

Pegcetacoplan is promising for paroxysmal nocturnal haemoglobinuria and Geographic Atrophy.

Is Tofacitinib effective for Ulcerative Colitis?

Yes. Tofacitinib, an oral small-molecule Janus kinase inhibitor, is effective in the treatment of moderate-severe ulcerative colitis. It is also effective treatment of rheumatoid arthritis and autoimmune encephalomyelitis.

For which indication has inotersen been approved?

Inoteresen has been approved for patients in stage 1 and stage 2 hereditary transthyretin amyloidosis polyneuropathy.

Is there any link between conserved noncoding elements and alternative splicing in vertebrates?

Yes. Some of the most highly conserved sequences occur in genes encoding RNA binding proteins, particularly the RNA splicing-associated SR genes.

What is the function of the protein encoded by PUMILIO1?

Pumilio1 (Pum1) has been shown to play key roles in translational regulation of target mRNAs in many systems of diverse organisms.

Which cells are affected in radiation-induced leukemias?

Hemopoietic stem cells, the possible target cells for radiation-induced leukemias.

Which mutations of alpha-myosin heavy chain gene are implicated in hypertrophic cardiomyopathy?

The following mutations of alpha-myosin heavy chain gene are implicated in hypertrophic cardiomyopathy: R403Q; Q1065H and Arg-249-->Gln

Which endothelial cell migration pathways were modulated at the gene expression level by rHDL-apoE3?

The most pronounced effect was observed for EC migration, with 42/198 genes being involved in the following EC migration-related pathways: 1) MEK/ERK, 2) PI3K/AKT/eNOS-MMP2/9, 3) RHO-GTPases, and 4) integrin.