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What is the drug target for Eliquis (Apixaban)?

The new oral anticoagulants (NOAC) Apixaban (Eliquis) is a direct anti-Xa inhibitors

The TRPM2 gene is associated with development of spontaneous thromboembolism?

TheTransientReceptorPotentialMelastatin 2 (TRPM2) is a member of G protein coupled receptor superfamily and a novel dual-function protein that possesses both ion channel andAdenosine 5'-DiphosPhataseRibose (ADPR) hydrolase function. TRPM2 is involved in Ca2+signaling in various cells as an endogenous redox sensor for oxidative stress and reactive oxygen species, and contributes to cytokine production, insulin release, motility, Ca2+entry and Ca2+-dependent cellular reactions such as endothelial hyper-permeability and apoptosis and may regulate the bacteriocidal activity of Macrophages

What is the effect of CPEB3 binding to the CPE domain?

The cytoplasmic polyadenylation element (CPE) is the binding platform for CPE-binding protein (CPEB), which promotes polyadenylation-induced translation.

Which plant is khellin extracted from?

Khellin is extracted from the seeds of the plant Ammi visnaga.

What is CellMaps?

CellMaps is an HTML5 open-source web tool that allows displaying, editing, exploring and analyzing biological networks as well as integrating metadata into them.

Which molecules are targeted by defactinib?

PURPOSE: VS-6063 (also known as defactinib or PF-04554878) is a second-generation inhibitor of focal adhesion kinase and proline-rich tyrosine kinase-2.

Are thyroid hormone receptor alpha1 mutations implicated in thyroid hormone resistance syndrome?

The lack of TR alpha1 exacerbates the manifestation of RTH in TR betaPV mice. Therefore, TR alpha1 could play a compensatory role in mediating the functions of T3 in heterozygous patients with RTH

What are the phases of hair follicle cycle?

Hair follicle cycle phases (anagen, catagen and telogen)

Which yeast genes encode for condensin?

Smc2-Smc4 forms the core of the Saccharomyces cerevisiae condensin, which promotes metaphase chromosome compaction . Both SMC2 and SMC4 are essential for chromosome transmission in anaphase . Smc 2-8 suppresses catenanes accumulation, mitotic arrest and growth defects induced by histone depletion at semi-permissive temperature .

Is L-4F an apoE mimetic peptide?

No, L-4F is an apoA-I mimetic peptide.

Which thyroid hormone transporter is implicated in thyroid hormone resistance syndrome?

thyroid hormone transporter MCT8 is implicated in thyroid hormone resistance syndrome

Which histone mark is recognized by HP1?

h3k9me3 is the major histone mark that is recognized by hp1.

What is TFBSshape?

To utilize DNA shape information when analysing the DNA binding specificities of TFs, the TFBSshape database was developed for calculating DNA structural features from nucleotide sequences provided by motif databases. The TFBSshape database can be used to generate heat maps and quantitative data for DNA structural features (i.e., minor groove width, roll, propeller twist and helix twist) for 739 TF datasets from 23 different species derived from the motif databases JASPAR and UniPROBE. As demonstrated for the basic helix-loop-helix and homeodomain TF families, TFBSshape database can be used to compare, qualitatively and quantitatively, the DNA binding specificities of closely related TFs and, thus, uncover differential DNA binding specificities that are not apparent from nucleotide sequence alone.

Which transcription factors are known as the four (4) "Yamanaka factors" that have been used to create induced pluripotent stem cells (iPSCs)?

Fibroblasts can be reprogrammed into induced pluripotent stem cells (iPSCs) by the application of Yamanaka factors (OSKM). In particular, the mechanisms how the Yamanaka factors (Oct4, Sox2, Klf4, and c-Myc) directly drive reprogramming and which additional components are involved are still not yet understood.

What are the main characteristics/symptoms of the "Brugada" syndrome

In 1992, Brugada and Brugada first described a new entity, which became known as Brugada syndrome, that is associated with a high risk of ventricular arrhythmias and sudden cardiac death in patients without structural heart disease. This syndrome is characterized by a distinct electrocardiographic phenotype, type 1 Brugada pattern, consisting of a coved ST-segment elevation (≥0.2 mV) followed by a negative T wave in more than one right precordial lead. The typical Brugada electrocardiogram (ECG) phenotype is often concealed in affected population. Brugada syndrome is a genetically determined familial disease with autosomal dominant transmission and variable penetrance, conferring a predisposition to sudden cardiac death due to ventricular arrhythmias. Brugada syndrome (BrS)is considered to be a primary inherited channelopathy often involving the inward sodium current and the diagnosis has traditionally required the exclusion of overt structural heart disease. Brugada syndrome (BrS) is an inherited cardiac disease characterized by ST segment elevation in V1-V3 ECG leads. Mutations SCN5A gene encoding for the cardiac voltage-gated Na(+) channel are found in some BrS patients, but also in family members with isolated conduction disturbances.

Which cellular processes are regulated by Nanog?

The pluripotency sustaining factor Nanog, controls a cascade of pathways that are intricately connected to govern pluripotency, self-renewal, genome surveillance and cell fate determination. Elevated expression of Nanog has also been reported to result in clonal expansion of murine ESCs, but it also plays a role in tumor development. A positive regulator of cell proliferation, it is essential for G1 to S transition in human embryonic stem cells while it regulates primordial germ cell migration.

List clinical phenotypes and molecular genetic features of patients with KMT2B-related disorders

Atypical patterns of dystonia evolution and a subgroup of patients presents with a non-dystonic neurodevelopmental phenotype. In addition to the previously reported systemic features there seem to be co-morbidities, including the risk of status dystonicus, intrauterine growth retardation, and endocrinopathies.

Does Serca2a bind PLN in the heart?

Yes, Serca2a bind PLN in the heart.

What cellular process are okazaki fragments associated with?

Okazaki fragments are involved in DNA replication

Which proteins induce inhibition of LINE-1 and Alu retrotransposition?

It was demonstrated that antiretroviral restriction factors, human APOBEC3 proteins A to H, differentially inhibit LINE-1 and Alu retrotransposition. The same effect was shown to be induced by the Aicardi-Goutières syndrome gene product SAMHD1.

Where are the PUX proteins found?

PUX proteins specifically associate with the nucleoskeleton underneath the INM.

Which type of analysis does DeSeq2 perform?

DeSeq2 is a software for differential gene expression analysis of RNA sequencing data.

What symptoms are included in the narcolepsy pentad?

Narcolepsy is a chronic sleep disorder characterized by a pentad of excessive daytime sleepiness (EDS), cataplexy, sleep paralysis, hypnagogic/hypnopompic hallucinations, and disturbed nocturnal sleep.

Is Hemochromatosis type 4 is caused by a mutation in a recessive gene?

No, Hemochromatosis type 4 is caused by an autosomal dominant gene

What is the role of LIMT lncRNA?

LINC01089 (LncRNA Inhibiting Metastasis; LIMT) is a highly conserved lncRNA, which is depleted in basal-like and in HER2-positive tumors, and the low expression of which predicts poor patient prognosis. Interestingly, EGF rapidly downregulates LIMT expression by enhancing histone deacetylation at the respective promoter. LIMT inhibits extracellular matrix invasion of mammary cells in vitro and tumor metastasis in vivo.

What is Q-nexus?

Q-nexus is a comprehensive and efficient analysis pipeline designed for ChIP-nexus.

As of Feb 2019, are major brain gangliosides a target for the treatment of Alzheimer's disease?

As of Feb 2019, major brain gangliosides are proposed as a target for the treatment of Alzheimer's disease.

List FDA approved treatments for androgenetic allopecia

Recently, in addition to the two currently approved U.S. Food and Drug Administration (FDA) medications (minoxidil and finasteride), a novel device was FDA-approved for the treatment of hair loss, the laser hair comb.

Which gene is frequently involved in autosomal dominant adult-onset demyelinating leukodystrophy (ADLD)?

Autosomal dominant leukodystrophy (ADLD) is an adult onset demyelinating disorder that is caused by duplications of the lamin B1 (LMNB1) gene.

List the proteins defining the triple negative breast cancer.

The so called "Triple Negative Breast Cancer" (TNBC) represents approximately 15-20% of breast cancers. This acronym simply means that the tumour does not express oestrogen receptor (ER) and progesterone receptor (PR) and does not exhibit amplification of the human epidermal growth factor receptor 2 (HER2) gene.

Is Cystatin D a biomarker?

Cystatin D (CST5): An ultra-early inflammatory biomarker of traumatic brain injury

Which are the different homologs or family members of the hedgehog proteins in mammals?

Hedgehog (Hh) signaling proteins stimulate cell proliferation, differentiation, and tissue patterning at multiple points in animal development. A single Hh homolog is present in Drosophila, but three Hh homologs, Sonic hedgehog (Shh), Indian hedgehog (Ihh) , and Desert hedgehog (Dhh), are present in mammals.

In which phase of clinical trials was sutezolid in 2018?

By 2018 sutezolid had been evaluated in phase II clinical trials.

Is SATB1 necessary for T-cell maturation?

Special AT-rich sequence binding protein 1 (SATB1) regulates gene expression essential in immune T-cell maturation and switching of fetal globin species, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin remodeling.

Is Rac1 involved in cancer cell invasion?

A number of signalling pathways have been found to converge to and activate Rac1, which, in turn, activates a number of downstream targets to control actin-cytoskeleton rearrangements at membrane ruffles, as well as formation and activity of lamellipodia, to regulate the migratory processes leading to cell invasion.

What are the phenotypic features of the autosomal dominant, development disease, Noonans syndrome

Noonan syndrome (NS) is an autosomal dominant disorder with vast heterogeneity in clinical and genetic features. Various symptoms have been reported for this abnormality such as short stature, unusual facial characteristics, congenital heart abnormalities, developmental complications, and an elevated tumor incidence rate

Can radiotherapy cause radiation induced osteosarcoma?

Yes, Radiation-induced osteosarcomas are a recognized complication of radiation therapy.

Are there any HCV replication inhibitors available?

Chronic hepatitis C virus (HCV) infection is a worldwide health problem causing serious complications, such as liver cirrhosis and hepatoma. Small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) have been reported to suppress gene expression significantly. HCV seems a suitable candidate for targets of siRNAs, as HCV is a positive single-strand RNA virus and replicates in the cytoplasm. Based on results, nowadays there are few HCV replication inhibitors such as GS-563253, PSI-6130, NA-808, BMS-790052, GS-9132 and BMS-788329.

Which histone mark distinguishes active from inactive enhancers?

Histone H3K27ac separates active from poised enhancers and predicts developmental state . In contrast, elements of the second class 'poised enhancers' are linked to genes inactive in hESCs . They are involved in orchestrating early steps in embryogenesis, such as gastrulation, mesoderm formation and neurulation .

The protein neprilysin has an positive effect on Alzheimer disease, how can it be delivered to the brain?

The protein neprilysin can be deliverered to the brain (crossing the blood brain barrier) through: gene tranfer, transgenesis, gene induction, ex-vivo gene therapy, intracardiac (peripheral) administration of viral neprilysin construct, syringe-focused ultrasound device, convection-enhanced delivery and the use of human adipose tissue-derived mesenchymal stem cells that secrete functional neprilysin-bound exosomes

What molecule is targeted by brodalumab?

Interleukin-17. Brodalumab is anti interleukin-17 monoclonal antibody.

What is the link between Dax1 and Esrrb?

Dax1 associates with Esrrb and regulates its function in embryonic stem cells

What is the role of photodynamic therapy for meningioma treatment?

Photodynamic therapy was shown to have activity againt meningioma treatment. Gefitinib and ciprofloxacin enhance efficacy of photodynamic therapy.

Can zinc finger nucleases be used to combat disease?

Yes, zinc finger nucleases are a useful tool for treating disease.

How is oprozomib administered?

Oprozomib is administered orally.

What is the effect of HMGB2 loss on CTCF clustering?

Depletion of the abundant HMGB2 protein occurs early on the path to senescence and coincides with the dramatic spatial clustering of CTCF. Knocking down HMGB2 suffices for senescence-induced CTCF clustering and for loop reshuffling, while ectopically expressing HMGB2 rescues these effects.

How many pseudogenes are contained in the C. elegans genome?

Evidence suggests that a fifth of annotated Caenorhabditis elegans genes may be pseudogenes. At least 4% of the annotated C. elegans genes can be recognized as pseudogenes simply from closer inspection of the sequence data. Thus out of 18000 transcripts, around 3500 are expected to be pseudogenes.

What are Syndecans?

Syndecans are transmembrane proteoglycans with heparan and chondroitin sulfate chains attached to their extracellular domain. Like many proteoglycans, they interact with a large number of ligands, such as growth factors, adhesion receptors, soluble small molecules, proteinases, and other extracellular matrix proteins to initiate downstream signaling pathways. Syndecans play a major role in inflammation, mainly by regulating leukocyte extravasation and cytokine function.

Is SLC22A3 expressed in the brain?

Yes, SLC22A3 (organic cation transporter (OCT3)) is widely expressed in various organs in humans, and involved in the disposition of many exogenous and endogenous compounds. Several lines of evidence have suggested that OCT3 expressed in the brain plays an important role in the regulation of neurotransmission.

What are chromones?

The chromones are a class of chemical compounds characterised by the presence of the structure 5:6 benz-1:4-pyrone in their chemical make-up.

Does nintedanib hold promise for lung disease associated with systemic sclerosis?

Yes, nintedanib holds promise for lung disease associated with systemic sclerosis. It is being tested in a clinical trial.

What is the mechanism of action of Ivosidenib?

Ivosidenib is an inhibitor of the IDH1 mutant enzyme that exhibits profound 2-HG lowering in tumor models. It is effective for IDH1-mutant relapsed/refractory acute myeloid leukemia.

Which human disease is associated with mutated UBQLN2

Ggene mutations in UBQLN2 cause dominant inheritance of amyotrophic lateral sclerosis (ALS).

Are there clinical trials using stem cells for the treatment of cardiac disease?

Yes, there exists clinical trials for cardiac stem cell based treatment.

Which R package is used for the analysis of genome-wide DNA methylation profiles?

MethylKit is a comprehensive R package for the analysis of genome-wide DNA methylation profiles. MethylKit includes functions for clustering, sample quality visualization, differential methylation analysis and annotation features, thus automating and simplifying many of the steps for discerning statistically significant bases or regions of DNA methylation.

Do de novo truncating mutations in WASF1 cause cancer?

No, de novo heterozygous mutations in WASF1 cause a rare form of intellectual disability.

Which hormone abnormalities are common in Williams syndrome

Elevated Thyrotropin - TSH Low FT4 Growth Hormone deficiency Calcitonin deficiency Elevated Prolactin Elevated Cortisol Elevated Oxytocin Elevated Vasopressin

Describe nextNEOpi

NextNEOpi is a comprehensive and fully-automated bioinformatic pipeline to predict tumor neoantigens from raw DNA and RNA sequencing data. In addition, nextNEOpi quantifies neoepitope- and patient-specific features associated with tumor immunogenicity and response to immunotherapy.

List all the available databases of super enhancers

dbSUPER and SEA are the available databases of super enhancers.

Which is the gene most commonly mutated in Tay-Sachs disease?

HEXA gene, encoding the alpha-subunit of the lysosomal enzyme, beta-N-acetylhexosaminidase A

Which transporter is inhibited by Sotagliflozin?

Sotagliflozin, a dual inhibitor of sodium-glucose co-transporters 1 and 2.

Which are the families of mammalian DNA-(cytosine-5)-methyltransferases?

DNA (cytosine-5)-methyltransferases catalyze the specific transfer of a methyl group to the C5 position of cytosine residues in DNA. Three families of DNA (cytosine-5)-methyltransferases have been identified in mammals: DNMT1, DNMT2 and DNMT3 (including DNMT3a, DNMT3b and DNMT3L isoforms). All of them share homologous catalytic domains. DNMT1 is the ���maintenance” methyltransferase family. DNMT1 is specific for hemi-methylated DNA and ensures the faithful transmission of DNA methylation patterns in every replication cycle. DNMT3 is required for de novo methylation of DNA. DNMT3 targets unmethylated DNA and is responsible for the establishment of new methylation patterns. Dnmt2, in contrast to all other mammalian DNA (cytosine-5)-methyltransferases, does not possess a large N-terminal regulatory domain. The DNA methylation activity of DNMT2 is still controversial.

Which trancription factor activates the betalain pathway?

The beet Y locus encodes an anthocyanin MYB-like protein that activates the betalain red pigment pathway.

What medication were compared in the ROCKET AF Trial?

ROCKET-AF trial compared rivaroxaban and warfarin for for prevention of stroke and embolism.

Are pseudogenes enriched with housekeeping protein families?

Yes, housekeeping families tend to be enriched with a large number of pseudogenes.

Is GAGA associated with nucleosome-free regions (NFR)?

The GAGA factor is a protein known to be involved in the formation and/or maintenance of nucleosome-free regions of chromatin. The interactions of GAGA factor and heat shock factor with their binding sites in chromatin occurred in two modes. Their interaction with binding sites in the nucleosome-free regions did not require ATP. In the presence of ATP both factors interacted also with nucleosomal binding sites, causing nucleosome rearrangements and a refinement of nucleosome positions. While chromatin remodeling upon transcription factor interaction has previously been interpreted to involve nucleosome disruption, the data suggest energy-dependent nucleosome sliding as main principle of chromatin reorganization.

Do the Sleeping Beauty or the piggyBac transposons have higher transposition efficiency?

Compared with Sleeping Beauty, PiggyBac exhibits higher transposition efficiencies.

What is the presumed key event in Fanconi anemia pathogenesis?

Monoubiquitination of the Fanconi anaemia protein FANCD2 is a key event leading to repair of interstrand cross-links. Failure of FANCD2 monoubiquitination by the nuclear FA protein complex has a severe impact on the DNA repair functions of cells.

Is microRNA(miRNA) 29 involved in post-ischemic cardiac remodeling?

miRNA 29 is involved in post-ischemic myocardial remodeling in particular in the peri-infarctual zone. miRNA 29 produces apoptosis and enhances fibrotic response.

What is septicemia?

Septicemia occurs when a bacterial infection elsewhere in the body, such as the lungs or skin, enters the bloodstream.

Is CD56 useful in Ewing sarcoma prognosis?

Excellent prognosis in a subset of patients with Ewing sarcoma identified at diagnosis by CD56 using flow cytometryIn patients with localized nonpelvic disease, those expressing low/negative CD56 had 100% PFS versus 40% in the high expressing group (P = 0.02)

Mutations in which gene have been found in patients with the CLAPO syndrome?

CLAPO syndrome is a rare vascular disorder characterized by capillary malformation of the lower lip, lymphatic malformation predominant on the face and neck, asymmetry, and partial/generalized overgrowth. In a cohort of 13 patients with CLAPO, five activating mutations have been identified in the PIK3CA gene in affected tissues from 6 of the 9 patients studied.

What are the indications for alteplase?

Intravenous alteplase (recombinant tissue plasminogen activator) is the only approved thrombolytic agent at present indicated for acute ischaemic stoke. Food and Drug Administration approval of alteplase for central venous catheter (CVC) occlusions. Alteplase is now firmly established as a treatment of choice in the management of acute myocardial infarction. The efficacy of intravenous alteplase in the treatment of pulmonary thromboembolism has also been established and appears to be similar to that of streptokinase and urokinase in this indication and in arterial thrombotic occlusion. However, its use in this latter indication and in other vascular disorders has not been as extensively documented. Preliminary data suggest efficacy of alteplase of deep vein thrombosis and arterial thrombotic occlusion.

For which diseases members of the 2-aminobenzamide class of histone deacetylase (HDAC) inhibitors show promise as therapeutics?

Members of the 2-aminobenzamide class of histone deacetylase (HDAC) inhibitors show promise as therapeutics for the neurodegenerative diseases Friedreich's ataxia (FRDA) and Huntington's disease (HD).

Can RG7112 inhibit MDM2?

Yes, RG7112 is a small molecule MDM2 antagonist.

Is progeria caused by an autosomal recessive gene?

Yes. Progeria is caused by an autosomal recessive gene.

Which disorder has been approved for treatment with Alk inhibitors?

Anaplastic lymphoma kinase (ALK) rearrangement is detected in 3-7% of patients with non-small-cell lung cancer. Crizotinib is an ALK inhibitor, which was approved in 2011 for the treatment of ALK-positive lung cancer.

List some substances important for proper nervous system function that gut microbes produce.

serotonin gamma-aminobutyric acid short-chain fatty acids neurotransmitters

Is there any link between ERCC1-XPF and cohesin?

Yes. ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes.

What is Cellbase?

CellBase, a comprehensive collection of RESTful web services for retrieving relevant biological information from heterogeneous sources.

What do studies show about the effect of Induced hypothermia in premature babies?

Randomised studies have demonstrated the efficacy of hypothermia for the treatment of perinatal hypoxic-ischaemic encephalopathy (HIE) in reducing rate of death or neurodevelopmental disabilities in term or late preterm infants. It remains unclear to what degree preterm infants were included in these studies. A prospective non-randomised pilot study reported that mild hypothermia for 48 hours in preterm neonates with severe NEC (necrotising enterocolitis) seems both feasible and safe.

List omics technologies comprised in system biology.

System biology combines various omics technologies such as genomics, transcriptomics, proteomics, metabolomics, epigenomics, glucomics, degradomics and fluxomics.

List places in the body where somatostatin is produced.

Somatostatin is a cyclic peptide well known for its strong regulatory effects throughout the body. Also known by the name of growth hormone inhibiting hormone, it is produced in many locations, which include the olfactory bulb, hair follicles, pancreas, retina, and central nervous system (CNS).

How much should be the duration of the QT interval in patients with short QT syndrome?

The short-QT syndrome is characterized by QT intervals <300-330 msec

Which is the prognostic meaning of delayed enhancement documented in patients hypertrophic cardiomyopathy?

Delayed enhancement by CMR has prognostic value in predicting adverse cardiovascular events among HCM patients, and is associated with cardiovascular mortality, heart failure death, and all-cause mortality in HCM.

What is the role of Thyrotropin Releasing Hormone in the treatment of comatose patients?

Thyrotropin Releasing Hormone and its analogs are used for treatment of comatose patients. In animal models, Thyrotropin Releasing Hormone and its analogs have been shown to improve the disturbance of consciousness caused by head concussion and pentobarbital. This analeptic action is attributable to stimulation of cholinergic neurons in the septo-hippocampal area and to the presence of terminals containing TRH in the lateral septum and TRH receptors concentrated especially in the medial septum and diagonal band of Broca. It has also been suggested that TRH localized in the pineal gland has a part in activating the neuronal mechanisms of arousal. Associated with the arousal effect and especially evident in variously originated shock conditions are the activating effects of TRH on vegetative functions (body temperature, circulation, the gastrointestinal tract). These stimulatory activities on the CNS were the rationale for therapeutic use of TRH in the initial treatment of coma due to brain trauma. Thyrotropin Releasing Hormone has been shown to induce recovery in comatose patients with extrapontine and pontine myelinosis syndromes.

Can exosomes be detected in urine?

Yes, urinary exosomes can be detected in urine.

Are immune cells affected in Amyotrophic Lateral Sclerosis?

In ALS T-cell deficiency increases neuronal loss, while boosting T cell levels reduces it.

How many genes outside of the MHC locus have been genetically associated to Rheumatoid Arthritis through GWAS?

Large genome-wide association studies (GWAS) have identified more than 30 loci involved in RA pathogenesis. To date, over 30 non-MHC RA-associated loci have been identified in humans, and over 100 arthritis-associated loci have been identified in rodent models of RA. The most relevant non-HLA gene single nucleotide polymorphisms (SNPs) associated with RA include PTPN22, IL23R, TRAF1, CTLA4, IRF5, STAT4, CCR6, PADI4. Previous studies demonstrate that 6 of the established non-HLA CD and RA risk loci (out of 26 loci for each disease) are shared between both diseases.

Which protein is associated with hyperemesis gravidarum during pregrancy?

Human chorionic gonadotropin (hCG) is associated with hyperemesis gravidarum during pregrancy.

Does thyroid hormone regulate calcium transient in the myocardium?

YES

How does FTO suppress pancreatic tumorigenesis?

Reduced expression of the m6A demethylase, fat mass and obesity-associated protein (FTO), was responsible for the high levels of m6A RNA modification in pancreatic cancer. Moreover, FTO demethylated the m6A modification of praja ring finger ubiquitin ligase 2 (PJA2), thereby reducing its mRNA decay, suppressing Wnt signaling, and ultimately restraining the proliferation, invasion, and metastasis of pancreatic cancer cells.

Is amantadine effective for treatment of disorders conciousness?

Amantadine, a dopaminergic agent, has been shown to be effective for induction of recovery from disorders of consciousness. Amantadine is a commonly prescribed medication for patients with prolonged disorders of consciousness after traumatic brain injury. Amantadine accelerates the pace of functional recovery during active treatment in patients with post-traumatic disorders of consciousness. Higher dosing of amantadine may be considered in the setting of brain injury.

Which proteins are markers of HPV oncogenic activity?

p16INK4a (p16) tumor-suppressor protein is a biomarker of human papillomavirus (HPV) oncogenic activity that has revealed a high rate of positivity in histological high-gade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 2 (HSIL/CIN2) lesions.

What is the chromosomal location of the LDL receptor gene associated with autosomal dominant Familial Hypercholesterolemia?

Familial hypercholesterolemia (FH) is an autosomal dominant inherited metabolic disorder resulting in advanced vascular atherosclerosis and premature death, primarily from coronary artery disease. The primary defect is a mutation in the gene encoding for the plasma LDL receptor located on the short arm of chromosome 19

A SLEDAI score is associated with Systemic Lupus Erythematosus. What is a SLEDAI score?

Disease activity of Systemic Lupus Erythematosis was evaluated according to the SLE Disease Activity Index (SLEDAI) score which score disease activity based on a number of parameters.

What is the function of the mammalian gene Irg1?

Human IRG1 and mouse Irg1 mediates antiviral and antimicrobial immune responses, without its exact role having been elucidated. Irg1 has been suggested to have a role in apoptosis and to play a significant role in embryonic implantation. Irg1 is reported as the mammalian ortholog of methylcitrate dehydratase.

What histone trimethylation has been associated to RNA splicing?

Mostly H3K36me3 but there is some evidence that H3K4me3 may also play a role in splicing

Does metformin interfere thyroxine absorption?

No. There are not reported data indicating that metformin reduce with thyroxine absorption.

What is PPROM?

Preterm premature(Prelabor) rupture of fetal membranes is often abbreviated as PPROM, and is defined as rupture of membranes before the onset of labor at < 37 weeks' gestation, affects approximately 3% of all pregnancies