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DS.d1036
18772894
[ { "id": "DS.d1036.s0", "type": "", "text": [ "Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men." ], "offsets": [ [ 0, 135 ] ] } ]
[ { "id": "DS.d1036.s0.e0", "type": "compound", "text": [ "conjugated linoleic acid" ], "offsets": [ [ 11, 35 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280644" }, { "db_name": "PubChem", "db_id": "5282796" } ] }, { "id": "DS.d1036.s0.e1", "type": "compound", "text": [ "polyunsaturated fatty acids" ], "offsets": [ [ 45, 72 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "56842239" } ] }, { "id": "DS.d1036.s0.e2", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 76, 83 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1036.s0.e3", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 108, 115 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
[ { "id": "DS.d1036.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1036.s0.e1", "arg2_id": "DS.d1036.s0.e2", "normalized": [] }, { "id": "DS.d1036.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1036.s0.e0", "arg2_id": "DS.d1036.s0.e2", "normalized": [] } ]
DS.d1037
18773149
[ { "id": "DS.d1037.s0", "type": "", "text": [ "A mechanism for the bioreduction of H2PtCl6 and PtCl2 into platinum nanoparticles by a hydrogenase enzyme from Fusarium oxysporum is proposed." ], "offsets": [ [ 0, 142 ] ] } ]
[ { "id": "DS.d1037.s0.e0", "type": "compound", "text": [ "platinum" ], "offsets": [ [ 59, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23939" } ] }, { "id": "DS.d1037.s0.e1", "type": "protein", "text": [ "hydrogenase" ], "offsets": [ [ 87, 98 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P80509" }, { "db_name": "UniProt", "db_id": "P80510" } ] } ]
[]
[]
[ { "id": "DS.d1037.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1037.s0.e0", "arg2_id": "DS.d1037.s0.e1", "normalized": [] } ]
DS.d1038
18773198
[ { "id": "DS.d1038.s0", "type": "", "text": [ "Responses of limbic and extrapyramidal substance P systems to nicotine treatment." ], "offsets": [ [ 0, 81 ] ] } ]
[ { "id": "DS.d1038.s0.e0", "type": "protein", "text": [ "substance P" ], "offsets": [ [ 39, 50 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01289" }, { "db_name": "UniProt", "db_id": "P06767" }, { "db_name": "UniProt", "db_id": "P19850" }, { "db_name": "UniProt", "db_id": "P20366" }, { "db_name": "UniProt", "db_id": "P28498" }, { "db_name": "UniProt", "db_id": "P28499" }, { "db_name": "UniProt", "db_id": "P41333" }, { "db_name": "UniProt", "db_id": "P41539" }, { "db_name": "UniProt", "db_id": "P41540" }, { "db_name": "UniProt", "db_id": "P67932" }, { "db_name": "UniProt", "db_id": "P67933" }, { "db_name": "UniProt", "db_id": "Q60541" } ] }, { "id": "DS.d1038.s0.e1", "type": "compound", "text": [ "nicotine" ], "offsets": [ [ 62, 70 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "942" }, { "db_name": "PubChem", "db_id": "89594" }, { "db_name": "PubChem", "db_id": "157672" } ] } ]
[]
[]
[ { "id": "DS.d1038.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1038.s0.e1", "arg2_id": "DS.d1038.s0.e0", "normalized": [] } ]
DS.d1039
18773247
[ { "id": "DS.d1039.s0", "type": "", "text": [ "Radioisotopic localization of (90) Yttrium-ibritumomab tiuxetan in patients with CD20+ non-Hodgkin's lymphoma." ], "offsets": [ [ 0, 110 ] ] } ]
[ { "id": "DS.d1039.s0.e0", "type": "compound", "text": [ "Yttrium" ], "offsets": [ [ 35, 42 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23993" } ] }, { "id": "DS.d1039.s0.e1", "type": "protein", "text": [ "CD20" ], "offsets": [ [ 81, 85 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11836" }, { "db_name": "UniProt", "db_id": "Q3C2E2" } ] } ]
[]
[]
[ { "id": "DS.d1039.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1039.s0.e0", "arg2_id": "DS.d1039.s0.e1", "normalized": [] } ]
DS.d1040
18773910
[ { "id": "DS.d1040.s0", "type": "", "text": [ "We solved the crystal structures of Aquifex aeolicus SPS and its complex with adenosine 5 '-(alpha,beta-methylene) triphosphate (AMPCPP)." ], "offsets": [ [ 0, 137 ] ] }, { "id": "DS.d1040.s1", "type": "", "text": [ "To identify the amino-acid residues that contribute to SPS activity, we prepared six mutants of SPS and examined their selenide-dependent ATP consumption." ], "offsets": [ [ 138, 292 ] ] }, { "id": "DS.d1040.s2", "type": "", "text": [ "In SPS. AMPCPP, the N-terminal loop, including the two residues, assumes different conformations (\"open\" and \"closed\") between the two subunits." ], "offsets": [ [ 293, 437 ] ] } ]
[ { "id": "DS.d1040.s0.e0", "type": "protein", "text": [ "SPS" ], "offsets": [ [ 53, 56 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31927" }, { "db_name": "UniProt", "db_id": "P49031" }, { "db_name": "UniProt", "db_id": "P49903" }, { "db_name": "UniProt", "db_id": "Q43845" }, { "db_name": "UniProt", "db_id": "Q43876" } ] }, { "id": "DS.d1040.s0.e1", "type": "compound", "text": [ "methylene" ], "offsets": [ [ 104, 113 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "123164" } ] }, { "id": "DS.d1040.s0.e2", "type": "compound", "text": [ "AMPCPP" ], "offsets": [ [ 129, 135 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "92199" } ] }, { "id": "DS.d1040.s1.e0", "type": "protein", "text": [ "SPS" ], "offsets": [ [ 193, 196 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31927" }, { "db_name": "UniProt", "db_id": "P49031" }, { "db_name": "UniProt", "db_id": "P49903" }, { "db_name": "UniProt", "db_id": "Q43845" }, { "db_name": "UniProt", "db_id": "Q43876" } ] }, { "id": "DS.d1040.s1.e1", "type": "protein", "text": [ "SPS" ], "offsets": [ [ 234, 237 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31927" }, { "db_name": "UniProt", "db_id": "P49031" }, { "db_name": "UniProt", "db_id": "P49903" }, { "db_name": "UniProt", "db_id": "Q43845" }, { "db_name": "UniProt", "db_id": "Q43876" } ] }, { "id": "DS.d1040.s1.e2", "type": "compound", "text": [ "selenide" ], "offsets": [ [ 257, 265 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "107674" } ] }, { "id": "DS.d1040.s2.e0", "type": "protein", "text": [ "SPS" ], "offsets": [ [ 296, 299 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31927" }, { "db_name": "UniProt", "db_id": "P49031" }, { "db_name": "UniProt", "db_id": "P49903" }, { "db_name": "UniProt", "db_id": "Q43845" }, { "db_name": "UniProt", "db_id": "Q43876" } ] }, { "id": "DS.d1040.s2.e1", "type": "compound", "text": [ "AMPCPP" ], "offsets": [ [ 301, 307 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "92199" } ] } ]
[]
[]
[ { "id": "DS.d1040.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1040.s0.e2", "arg2_id": "DS.d1040.s0.e0", "normalized": [] }, { "id": "DS.d1040.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1040.s0.e1", "arg2_id": "DS.d1040.s0.e0", "normalized": [] }, { "id": "DS.d1040.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1040.s1.e2", "arg2_id": "DS.d1040.s1.e0", "normalized": [] }, { "id": "DS.d1040.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1040.s2.e1", "arg2_id": "DS.d1040.s2.e0", "normalized": [] } ]
DS.d1041
18773925
[ { "id": "DS.d1041.s0", "type": "", "text": [ "The results indicated that CB1 receptors within the nucleus accumbens are involved in the acquisition and expression of morphine-induced CPP in sensitized rats." ], "offsets": [ [ 0, 160 ] ] } ]
[ { "id": "DS.d1041.s0.e0", "type": "protein", "text": [ "CB1" ], "offsets": [ [ 27, 30 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02777" }, { "db_name": "UniProt", "db_id": "P20272" }, { "db_name": "UniProt", "db_id": "P21554" }, { "db_name": "UniProt", "db_id": "P47746" }, { "db_name": "UniProt", "db_id": "P56971" }, { "db_name": "UniProt", "db_id": "Q333S9" }, { "db_name": "UniProt", "db_id": "Q5IS73" }, { "db_name": "UniProt", "db_id": "Q71SP5" }, { "db_name": "UniProt", "db_id": "Q801M1" }, { "db_name": "UniProt", "db_id": "Q9PUI7" } ] }, { "id": "DS.d1041.s0.e1", "type": "compound", "text": [ "morphine" ], "offsets": [ [ 120, 128 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5288826" }, { "db_name": "PubChem", "db_id": "5479215" } ] } ]
[]
[]
[ { "id": "DS.d1041.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1041.s0.e1", "arg2_id": "DS.d1041.s0.e0", "normalized": [] } ]
DS.d1042
18773927
[ { "id": "DS.d1042.s0", "type": "", "text": [ "Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas." ], "offsets": [ [ 0, 97 ] ] }, { "id": "DS.d1042.s1", "type": "", "text": [ "The potentiated effect of obestatin on glucose-induced insulin output was not observed in the presence of diazoxide, an agent that activates ATP-dependent K(+) channels, thus suggesting that these channels might be sensitive to this peptide." ], "offsets": [ [ 98, 339 ] ] } ]
[ { "id": "DS.d1042.s0.e0", "type": "protein", "text": [ "obestatin" ], "offsets": [ [ 10, 19 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q6BEG6" }, { "db_name": "UniProt", "db_id": "Q6BEG7" }, { "db_name": "UniProt", "db_id": "Q9BDJ6" }, { "db_name": "UniProt", "db_id": "Q9BEF8" }, { "db_name": "UniProt", "db_id": "Q9EQX0" }, { "db_name": "UniProt", "db_id": "Q9GKY5" }, { "db_name": "UniProt", "db_id": "Q9UBU3" } ] }, { "id": "DS.d1042.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 23, 30 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1042.s0.e2", "type": "protein", "text": [ "glucagon" ], "offsets": [ [ 32, 40 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12956" }, { "db_name": "UniProt", "db_id": "O42143" }, { "db_name": "UniProt", "db_id": "O42144" }, { "db_name": "UniProt", "db_id": "P01272" }, { "db_name": "UniProt", "db_id": "P01273" }, { "db_name": "UniProt", "db_id": "P01274" }, { "db_name": "UniProt", "db_id": "P01275" }, { "db_name": "UniProt", "db_id": "P04093" }, { "db_name": "UniProt", "db_id": "P05110" }, { "db_name": "UniProt", "db_id": "P06883" }, { "db_name": "UniProt", "db_id": "P07449" }, { "db_name": "UniProt", "db_id": "P09566" }, { "db_name": "UniProt", "db_id": "P09567" }, { "db_name": "UniProt", "db_id": "P09682" }, { "db_name": "UniProt", "db_id": "P09686" }, { "db_name": "UniProt", "db_id": "P0C235" }, { "db_name": "UniProt", "db_id": "P13189" }, { "db_name": "UniProt", "db_id": "P15438" }, { "db_name": "UniProt", "db_id": "P18108" }, { "db_name": "UniProt", "db_id": "P22890" }, { "db_name": "UniProt", "db_id": "P29794" }, { "db_name": "UniProt", "db_id": "P31297" }, { "db_name": "UniProt", "db_id": "P33528" }, { "db_name": "UniProt", "db_id": "P55095" }, { "db_name": "UniProt", "db_id": "P68259" }, { "db_name": "UniProt", "db_id": "P68260" }, { "db_name": "UniProt", "db_id": "P68273" }, { "db_name": "UniProt", "db_id": "P68274" }, { "db_name": "UniProt", "db_id": "P68275" }, { "db_name": "UniProt", "db_id": "P68952" }, { "db_name": "UniProt", "db_id": "P68953" }, { "db_name": "UniProt", "db_id": "P68954" }, { "db_name": "UniProt", "db_id": "P68955" }, { "db_name": "UniProt", "db_id": "P68956" }, { "db_name": "UniProt", "db_id": "P68957" }, { "db_name": "UniProt", "db_id": "P79695" }, { "db_name": "UniProt", "db_id": "P81880" }, { "db_name": "UniProt", "db_id": "Q8MJ25" }, { "db_name": "UniProt", "db_id": "Q9PRQ9" } ] }, { "id": "DS.d1042.s0.e3", "type": "compound", "text": [ "somatostatin" ], "offsets": [ [ 45, 57 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16129681" }, { "db_name": "PubChem", "db_id": "16129706" } ] }, { "id": "DS.d1042.s1.e0", "type": "protein", "text": [ "obestatin" ], "offsets": [ [ 124, 133 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q6BEG6" }, { "db_name": "UniProt", "db_id": "Q6BEG7" }, { "db_name": "UniProt", "db_id": "Q9BDJ6" }, { "db_name": "UniProt", "db_id": "Q9BEF8" }, { "db_name": "UniProt", "db_id": "Q9EQX0" }, { "db_name": "UniProt", "db_id": "Q9GKY5" }, { "db_name": "UniProt", "db_id": "Q9UBU3" } ] }, { "id": "DS.d1042.s1.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 137, 144 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1042.s1.e2", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 153, 160 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1042.s1.e3", "type": "compound", "text": [ "diazoxide" ], "offsets": [ [ 204, 213 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3019" } ] } ]
[]
[]
[ { "id": "DS.d1042.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1042.s0.e3", "arg2_id": "DS.d1042.s0.e0", "normalized": [] }, { "id": "DS.d1042.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1042.s1.e1", "arg2_id": "DS.d1042.s1.e2", "normalized": [] }, { "id": "DS.d1042.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1042.s1.e1", "arg2_id": "DS.d1042.s1.e0", "normalized": [] }, { "id": "DS.d1042.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1042.s1.e3", "arg2_id": "DS.d1042.s1.e2", "normalized": [] }, { "id": "DS.d1042.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1042.s1.e3", "arg2_id": "DS.d1042.s1.e0", "normalized": [] } ]
DS.d1043
18773954
[ { "id": "DS.d1043.s0", "type": "", "text": [ "Four brain areas (cortex, hippocampus, thalamus and hypothalamus) were analyzed for EB extravasation, water and electrolyte (Na (+), K(+), Cl (-)) contents, immunostained for albumin and glial fibrillary acidic protein (GFAP), and examined for neuronal, glial and axonal alterations using standard light and electron microscopy." ], "offsets": [ [ 0, 328 ] ] } ]
[ { "id": "DS.d1043.s0.e0", "type": "compound", "text": [ "Na" ], "offsets": [ [ 125, 127 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "923" }, { "db_name": "PubChem", "db_id": "373840" } ] }, { "id": "DS.d1043.s0.e1", "type": "compound", "text": [ "Cl" ], "offsets": [ [ 139, 141 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "312" } ] }, { "id": "DS.d1043.s0.e2", "type": "protein", "text": [ "acidic protein" ], "offsets": [ [ 204, 218 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01538" }, { "db_name": "UniProt", "db_id": "P01543" }, { "db_name": "UniProt", "db_id": "P01544" }, { "db_name": "UniProt", "db_id": "P01545" }, { "db_name": "UniProt", "db_id": "P08772" }, { "db_name": "UniProt", "db_id": "P08943" }, { "db_name": "UniProt", "db_id": "P09617" }, { "db_name": "UniProt", "db_id": "P09618" }, { "db_name": "UniProt", "db_id": "P21742" }, { "db_name": "UniProt", "db_id": "P32032" }, { "db_name": "UniProt", "db_id": "Q05806" }, { "db_name": "UniProt", "db_id": "Q42596" }, { "db_name": "UniProt", "db_id": "Q42597" }, { "db_name": "UniProt", "db_id": "Q42838" }, { "db_name": "UniProt", "db_id": "Q8H0Q5" }, { "db_name": "UniProt", "db_id": "Q8VZK8" }, { "db_name": "UniProt", "db_id": "Q9C8D6" }, { "db_name": "UniProt", "db_id": "Q9SBK8" } ] }, { "id": "DS.d1043.s0.e3", "type": "protein", "text": [ "GFAP" ], "offsets": [ [ 220, 224 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03995" }, { "db_name": "UniProt", "db_id": "P14136" }, { "db_name": "UniProt", "db_id": "P47819" }, { "db_name": "UniProt", "db_id": "Q28115" } ] } ]
[]
[]
[]
DS.d1044
18773955
[ { "id": "DS.d1044.s0", "type": "", "text": [ "We administered parathion to newborn rats on postnatal days (PN) 1-4 at doses spanning the threshold for detectable cholinesterase inhibition (0.1 mg/kg/day) and the first signs of loss of viability (0.2 mg/kg/day)." ], "offsets": [ [ 0, 215 ] ] } ]
[ { "id": "DS.d1044.s0.e0", "type": "compound", "text": [ "parathion" ], "offsets": [ [ 16, 25 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "991" } ] }, { "id": "DS.d1044.s0.e1", "type": "protein", "text": [ "cholinesterase" ], "offsets": [ [ 116, 130 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P32749" }, { "db_name": "UniProt", "db_id": "P32750" }, { "db_name": "UniProt", "db_id": "P32751" }, { "db_name": "UniProt", "db_id": "P32752" }, { "db_name": "UniProt", "db_id": "P32753" }, { "db_name": "UniProt", "db_id": "P81908" } ] } ]
[]
[]
[ { "id": "DS.d1044.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1044.s0.e0", "arg2_id": "DS.d1044.s0.e1", "normalized": [] } ]
DS.d1045
18774132
[ { "id": "DS.d1045.s0", "type": "", "text": [ "The Arg105 in GLUT10 is highly conserved across species and its replacement with cysteine is predicted to be pathogenic." ], "offsets": [ [ 0, 120 ] ] } ]
[ { "id": "DS.d1045.s0.e0", "type": "protein", "text": [ "GLUT10" ], "offsets": [ [ 14, 20 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O95528" }, { "db_name": "UniProt", "db_id": "Q9BYW1" } ] }, { "id": "DS.d1045.s0.e1", "type": "compound", "text": [ "cysteine" ], "offsets": [ [ 81, 89 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "594" }, { "db_name": "PubChem", "db_id": "5862" }, { "db_name": "PubChem", "db_id": "5360637" } ] } ]
[]
[]
[ { "id": "DS.d1045.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1045.s0.e1", "arg2_id": "DS.d1045.s0.e0", "normalized": [] } ]
DS.d1046
18774203
[ { "id": "DS.d1046.s0", "type": "", "text": [ "(Ofloxacin is contraindicated in case of G6PD deficiency: is it evidenced based?)." ], "offsets": [ [ 0, 82 ] ] } ]
[ { "id": "DS.d1046.s0.e0", "type": "compound", "text": [ "(Ofloxacin" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4583" }, { "db_name": "PubChem", "db_id": "149096" }, { "db_name": "PubChem", "db_id": "452723" } ] }, { "id": "DS.d1046.s0.e1", "type": "protein", "text": [ "G6PD" ], "offsets": [ [ 41, 45 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00091" }, { "db_name": "UniProt", "db_id": "O24357" }, { "db_name": "UniProt", "db_id": "O51581" }, { "db_name": "UniProt", "db_id": "O54537" }, { "db_name": "UniProt", "db_id": "O55044" }, { "db_name": "UniProt", "db_id": "O68282" }, { "db_name": "UniProt", "db_id": "O83491" }, { "db_name": "UniProt", "db_id": "O84188" }, { "db_name": "UniProt", "db_id": "P05370" }, { "db_name": "UniProt", "db_id": "P0A584" }, { "db_name": "UniProt", "db_id": "P0A585" }, { "db_name": "UniProt", "db_id": "P0A586" }, { "db_name": "UniProt", "db_id": "P0A587" }, { "db_name": "UniProt", "db_id": "P0AC53" }, { "db_name": "UniProt", "db_id": "P0AC54" }, { "db_name": "UniProt", "db_id": "P11410" }, { "db_name": "UniProt", "db_id": "P11411" }, { "db_name": "UniProt", "db_id": "P11412" }, { "db_name": "UniProt", "db_id": "P11413" }, { "db_name": "UniProt", "db_id": "P12646" }, { "db_name": "UniProt", "db_id": "P15588" }, { "db_name": "UniProt", "db_id": "P21907" }, { "db_name": "UniProt", "db_id": "P29686" }, { "db_name": "UniProt", "db_id": "P37830" }, { "db_name": "UniProt", "db_id": "P37986" }, { "db_name": "UniProt", "db_id": "P41571" }, { "db_name": "UniProt", "db_id": "P41764" }, { "db_name": "UniProt", "db_id": "P44311" }, { "db_name": "UniProt", "db_id": "P48826" }, { "db_name": "UniProt", "db_id": "P48828" }, { "db_name": "UniProt", "db_id": "P48848" }, { "db_name": "UniProt", "db_id": "P48992" }, { "db_name": "UniProt", "db_id": "P54547" }, { "db_name": "UniProt", "db_id": "P54996" }, { "db_name": "UniProt", "db_id": "P56110" }, { "db_name": "UniProt", "db_id": "P57405" }, { "db_name": "UniProt", "db_id": "P73411" }, { "db_name": "UniProt", "db_id": "P77809" }, { "db_name": "UniProt", "db_id": "P80619" }, { "db_name": "UniProt", "db_id": "P97324" }, { "db_name": "UniProt", "db_id": "Q00612" }, { "db_name": "UniProt", "db_id": "Q23711" }, { "db_name": "UniProt", "db_id": "Q24625" }, { "db_name": "UniProt", "db_id": "Q25019" }, { "db_name": "UniProt", "db_id": "Q25537" }, { "db_name": "UniProt", "db_id": "Q27464" }, { "db_name": "UniProt", "db_id": "Q27638" }, { "db_name": "UniProt", "db_id": "Q29492" }, { "db_name": "UniProt", "db_id": "Q42919" }, { "db_name": "UniProt", "db_id": "Q43793" }, { "db_name": "UniProt", "db_id": "Q43839" }, { "db_name": "UniProt", "db_id": "Q7YS37" }, { "db_name": "UniProt", "db_id": "Q89AI7" }, { "db_name": "UniProt", "db_id": "Q8K9M2" }, { "db_name": "UniProt", "db_id": "Q8XCJ6" }, { "db_name": "UniProt", "db_id": "Q9PKK8" }, { "db_name": "UniProt", "db_id": "Q9X0N9" }, { "db_name": "UniProt", "db_id": "Q9Z3S2" }, { "db_name": "UniProt", "db_id": "Q9Z8U6" }, { "db_name": "UniProt", "db_id": "Q9ZKB2" } ] } ]
[]
[]
[]
DS.d1047
18774319
[ { "id": "DS.d1047.s0", "type": "", "text": [ "We also assess prostaglandin (PGE (2)) and thromboxane (TXB (2)) inhibition to establish the correlation between behavioural measures and the degree of selectivity for COX-1 and COX-2." ], "offsets": [ [ 0, 184 ] ] } ]
[ { "id": "DS.d1047.s0.e0", "type": "protein", "text": [ "PGE" ], "offsets": [ [ 30, 33 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q29458" } ] }, { "id": "DS.d1047.s0.e1", "type": "compound", "text": [ "thromboxane" ], "offsets": [ [ 43, 54 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "114873" } ] }, { "id": "DS.d1047.s0.e2", "type": "compound", "text": [ "TXB" ], "offsets": [ [ 56, 59 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9548654" } ] }, { "id": "DS.d1047.s0.e3", "type": "protein", "text": [ "COX-1" ], "offsets": [ [ 168, 173 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62664" }, { "db_name": "UniProt", "db_id": "O97554" }, { "db_name": "UniProt", "db_id": "P05979" }, { "db_name": "UniProt", "db_id": "P22437" }, { "db_name": "UniProt", "db_id": "P23219" }, { "db_name": "UniProt", "db_id": "Q63921" }, { "db_name": "UniProt", "db_id": "Q9T0N8" } ] }, { "id": "DS.d1047.s0.e4", "type": "protein", "text": [ "COX-2" ], "offsets": [ [ 178, 183 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] } ]
[]
[]
[]
DS.d1048
18774664
[ { "id": "DS.d1048.s0", "type": "", "text": [ "High-dose steroid therapy for the former symptoms of AHS, and immunoglobulin, granulocyte colony-stimulating factor, and cefepime for the latter agranulocytosis were successfully performed." ], "offsets": [ [ 0, 189 ] ] } ]
[ { "id": "DS.d1048.s0.e0", "type": "protein", "text": [ "granulocyte colony-stimulating factor" ], "offsets": [ [ 78, 115 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P35834" }, { "db_name": "UniProt", "db_id": "Q28746" } ] }, { "id": "DS.d1048.s0.e1", "type": "compound", "text": [ "cefepime" ], "offsets": [ [ 121, 129 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5491295" } ] } ]
[]
[]
[]
DS.d1049
18774689
[ { "id": "DS.d1049.s0", "type": "", "text": [ "0.05 vs. aortic IR) plasma levels of malondialdehyde, P-selectin, intercellular adhesion molecule-1 (ICAM-I), and tissue levels of malondialdehyde and catalase." ], "offsets": [ [ 0, 160 ] ] } ]
[ { "id": "DS.d1049.s0.e0", "type": "compound", "text": [ "malondialdehyde" ], "offsets": [ [ 37, 52 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10964" } ] }, { "id": "DS.d1049.s0.e1", "type": "compound", "text": [ "malondialdehyde" ], "offsets": [ [ 131, 146 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10964" } ] }, { "id": "DS.d1049.s0.e2", "type": "protein", "text": [ "catalase" ], "offsets": [ [ 151, 159 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24339" }, { "db_name": "UniProt", "db_id": "O52762" }, { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O68146" }, { "db_name": "UniProt", "db_id": "O77229" }, { "db_name": "UniProt", "db_id": "O93662" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P04762" }, { "db_name": "UniProt", "db_id": "P07145" }, { "db_name": "UniProt", "db_id": "P0A323" }, { "db_name": "UniProt", "db_id": "P0A324" }, { "db_name": "UniProt", "db_id": "P0A325" }, { "db_name": "UniProt", "db_id": "P0A326" }, { "db_name": "UniProt", "db_id": "P0A327" }, { "db_name": "UniProt", "db_id": "P11934" }, { "db_name": "UniProt", "db_id": "P17336" }, { "db_name": "UniProt", "db_id": "P24168" }, { "db_name": "UniProt", "db_id": "P24270" }, { "db_name": "UniProt", "db_id": "P25890" }, { "db_name": "UniProt", "db_id": "P29422" }, { "db_name": "UniProt", "db_id": "P30265" }, { "db_name": "UniProt", "db_id": "P30266" }, { "db_name": "UniProt", "db_id": "P32290" }, { "db_name": "UniProt", "db_id": "P42321" }, { "db_name": "UniProt", "db_id": "P44390" }, { "db_name": "UniProt", "db_id": "P45737" }, { "db_name": "UniProt", "db_id": "P45739" }, { "db_name": "UniProt", "db_id": "P55304" }, { "db_name": "UniProt", "db_id": "P55306" }, { "db_name": "UniProt", "db_id": "P55310" }, { "db_name": "UniProt", "db_id": "P55311" }, { "db_name": "UniProt", "db_id": "P55313" }, { "db_name": "UniProt", "db_id": "P77872" }, { "db_name": "UniProt", "db_id": "P81138" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q27710" }, { "db_name": "UniProt", "db_id": "Q49XC1" }, { "db_name": "UniProt", "db_id": "Q4L643" }, { "db_name": "UniProt", "db_id": "Q59296" }, { "db_name": "UniProt", "db_id": "Q59337" }, { "db_name": "UniProt", "db_id": "Q59602" }, { "db_name": "UniProt", "db_id": "Q59714" }, { "db_name": "UniProt", "db_id": "Q5HG86" }, { "db_name": "UniProt", "db_id": "Q5HPK8" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q6G9M4" }, { "db_name": "UniProt", "db_id": "Q6GH72" }, { "db_name": "UniProt", "db_id": "Q7A5T2" }, { "db_name": "UniProt", "db_id": "Q8CPD0" }, { "db_name": "UniProt", "db_id": "Q8FWU0" }, { "db_name": "UniProt", "db_id": "Q8NWV5" }, { "db_name": "UniProt", "db_id": "Q8X1P0" }, { "db_name": "UniProt", "db_id": "Q8Y3P9" }, { "db_name": "UniProt", "db_id": "Q926X0" }, { "db_name": "UniProt", "db_id": "Q99UE2" }, { "db_name": "UniProt", "db_id": "Q9AXH0" }, { "db_name": "UniProt", "db_id": "Q9KW19" }, { "db_name": "UniProt", "db_id": "Q9L4S1" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PT92" }, { "db_name": "UniProt", "db_id": "Q9PWF7" }, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] } ]
[]
[]
[]
DS.d1050
18774957
[ { "id": "DS.d1050.s0", "type": "", "text": [ "Niemann-Pick C disease (NPC) is an autosomal recessive neurodegenerative disorder caused by the abnormal function of NPC1 or NPC2 proteins, leading to an accumulation of unesterified cholesterol and glycosphingolipids (GSLs) in the lysosomes." ], "offsets": [ [ 0, 242 ] ] } ]
[ { "id": "DS.d1050.s0.e0", "type": "protein", "text": [ "NPC1" ], "offsets": [ [ 117, 121 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15118" }, { "db_name": "UniProt", "db_id": "P56941" } ] }, { "id": "DS.d1050.s0.e1", "type": "protein", "text": [ "NPC2" ], "offsets": [ [ 125, 129 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O93388" }, { "db_name": "UniProt", "db_id": "O97763" }, { "db_name": "UniProt", "db_id": "P61916" }, { "db_name": "UniProt", "db_id": "P61917" }, { "db_name": "UniProt", "db_id": "P61918" }, { "db_name": "UniProt", "db_id": "P79345" }, { "db_name": "UniProt", "db_id": "Q12408" }, { "db_name": "UniProt", "db_id": "Q28895" }, { "db_name": "UniProt", "db_id": "Q4P580" }, { "db_name": "UniProt", "db_id": "Q52FS9" }, { "db_name": "UniProt", "db_id": "Q5A8A2" }, { "db_name": "UniProt", "db_id": "Q5KIR9" }, { "db_name": "UniProt", "db_id": "Q6BV42" }, { "db_name": "UniProt", "db_id": "Q6CHU5" }, { "db_name": "UniProt", "db_id": "Q6CNE0" }, { "db_name": "UniProt", "db_id": "Q6FNB1" }, { "db_name": "UniProt", "db_id": "Q756Q3" }, { "db_name": "UniProt", "db_id": "Q9VQ62" } ] }, { "id": "DS.d1050.s0.e2", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 183, 194 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] } ]
[]
[]
[ { "id": "DS.d1050.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1050.s0.e2", "arg2_id": "DS.d1050.s0.e0", "normalized": [] }, { "id": "DS.d1050.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1050.s0.e2", "arg2_id": "DS.d1050.s0.e1", "normalized": [] } ]
DS.d1051
18775028
[ { "id": "DS.d1051.s0", "type": "", "text": [ "arginase-diminished arginine and indolamine 2,3-dioxygenase-diminished tryptophan) or nitric oxide (NO) production." ], "offsets": [ [ 0, 115 ] ] } ]
[ { "id": "DS.d1051.s0.e0", "type": "protein", "text": [ "arginase" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O49046" }, { "db_name": "UniProt", "db_id": "P00812" }, { "db_name": "UniProt", "db_id": "P0A2X9" }, { "db_name": "UniProt", "db_id": "P0A2Y0" }, { "db_name": "UniProt", "db_id": "P0A2Y1" }, { "db_name": "UniProt", "db_id": "P14012" }, { "db_name": "UniProt", "db_id": "P33280" }, { "db_name": "UniProt", "db_id": "P37818" }, { "db_name": "UniProt", "db_id": "P39138" }, { "db_name": "UniProt", "db_id": "P40906" }, { "db_name": "UniProt", "db_id": "P46637" }, { "db_name": "UniProt", "db_id": "P53608" }, { "db_name": "UniProt", "db_id": "P60086" }, { "db_name": "UniProt", "db_id": "P60087" }, { "db_name": "UniProt", "db_id": "P60088" }, { "db_name": "UniProt", "db_id": "Q10066" }, { "db_name": "UniProt", "db_id": "Q12611" }, { "db_name": "UniProt", "db_id": "Q1E180" }, { "db_name": "UniProt", "db_id": "Q6G7E9" }, { "db_name": "UniProt", "db_id": "Q6GER3" }, { "db_name": "UniProt", "db_id": "Q74ZW4" }, { "db_name": "UniProt", "db_id": "Q7M0Z3" }, { "db_name": "UniProt", "db_id": "Q8NVE3" } ] }, { "id": "DS.d1051.s0.e1", "type": "compound", "text": [ "arginine" ], "offsets": [ [ 20, 28 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "232" }, { "db_name": "PubChem", "db_id": "4367" }, { "db_name": "PubChem", "db_id": "6322" } ] }, { "id": "DS.d1051.s0.e2", "type": "compound", "text": [ "tryptophan" ], "offsets": [ [ 71, 81 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1148" }, { "db_name": "PubChem", "db_id": "6305" }, { "db_name": "PubChem", "db_id": "9060" }, { "db_name": "PubChem", "db_id": "5460840" } ] }, { "id": "DS.d1051.s0.e3", "type": "compound", "text": [ "nitric oxide" ], "offsets": [ [ 86, 98 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] } ]
[]
[]
[ { "id": "DS.d1051.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1051.s0.e1", "arg2_id": "DS.d1051.s0.e0", "normalized": [] } ]
DS.d1052
18775088
[ { "id": "DS.d1052.s0", "type": "", "text": [ "Memory impairment in young women at increased risk of depression: influence of cortisol and 5-HTT genotype." ], "offsets": [ [ 0, 107 ] ] }, { "id": "DS.d1052.s1", "type": "", "text": [ "The aim of the present study was to determine whether memory impairments were present in young women at increased familial risk of depression and whether memory performance was related either to cortisol secretion or to allelic variation in the promoter region of the serotonin transporter gene (5-HTT)." ], "offsets": [ [ 108, 411 ] ] } ]
[ { "id": "DS.d1052.s0.e0", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 79, 87 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] }, { "id": "DS.d1052.s0.e1", "type": "protein", "text": [ "HTT" ], "offsets": [ [ 94, 97 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31645" } ] }, { "id": "DS.d1052.s1.e0", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 303, 311 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] }, { "id": "DS.d1052.s1.e1", "type": "protein", "text": [ "HTT" ], "offsets": [ [ 406, 409 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31645" } ] } ]
[]
[]
[]
DS.d1053
18775090
[ { "id": "DS.d1053.s0", "type": "", "text": [ "The relative gene expression of cytochrome c 0.05) in-Cu calves compared with+ Cu or-Cu+Mn calves." ], "offsets": [ [ 0, 98 ] ] } ]
[ { "id": "DS.d1053.s0.e0", "type": "protein", "text": [ "cytochrome c" ], "offsets": [ [ 32, 44 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O07091" }, { "db_name": "UniProt", "db_id": "O13393" }, { "db_name": "UniProt", "db_id": "O22642" }, { "db_name": "UniProt", "db_id": "O93863" }, { "db_name": "UniProt", "db_id": "P00002" }, { "db_name": "UniProt", "db_id": "P00003" }, { "db_name": "UniProt", "db_id": "P00004" }, { "db_name": "UniProt", "db_id": "P00007" }, { "db_name": "UniProt", "db_id": "P00008" }, { "db_name": "UniProt", "db_id": "P00011" }, { "db_name": "UniProt", "db_id": "P00012" }, { "db_name": "UniProt", "db_id": "P00013" }, { "db_name": "UniProt", "db_id": "P00014" }, { "db_name": "UniProt", "db_id": "P00017" }, { "db_name": "UniProt", "db_id": "P00018" }, { "db_name": "UniProt", "db_id": "P00019" }, { "db_name": "UniProt", "db_id": "P00020" }, { "db_name": "UniProt", "db_id": "P00021" }, { "db_name": "UniProt", "db_id": "P00022" }, { "db_name": "UniProt", "db_id": "P00024" }, { "db_name": "UniProt", "db_id": "P00025" }, { "db_name": "UniProt", "db_id": "P00027" }, { "db_name": "UniProt", "db_id": "P00028" }, { "db_name": "UniProt", "db_id": "P00029" }, { "db_name": "UniProt", "db_id": "P00030" }, { "db_name": "UniProt", "db_id": "P00031" }, { "db_name": "UniProt", "db_id": "P00032" }, { "db_name": "UniProt", "db_id": "P00035" }, { "db_name": "UniProt", "db_id": "P00036" }, { "db_name": "UniProt", "db_id": "P00037" }, { "db_name": "UniProt", "db_id": "P00038" }, { "db_name": "UniProt", "db_id": "P00039" }, { "db_name": "UniProt", "db_id": "P00040" }, { "db_name": "UniProt", "db_id": "P00041" }, { "db_name": "UniProt", "db_id": "P00042" }, { "db_name": "UniProt", "db_id": "P00043" }, { "db_name": "UniProt", "db_id": "P00046" }, { "db_name": "UniProt", "db_id": "P00047" }, { "db_name": "UniProt", "db_id": "P00048" }, { "db_name": "UniProt", "db_id": "P00049" }, { "db_name": "UniProt", "db_id": "P00051" }, { "db_name": "UniProt", "db_id": 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}, { "db_name": "UniProt", "db_id": "P00075" }, { "db_name": "UniProt", "db_id": "P00076" }, { "db_name": "UniProt", "db_id": "P00077" }, { "db_name": "UniProt", "db_id": "P00078" }, { "db_name": "UniProt", "db_id": "P00079" }, { "db_name": "UniProt", "db_id": "P12831" }, { "db_name": "UniProt", "db_id": "P15451" }, { "db_name": "UniProt", "db_id": "P18822" }, { "db_name": "UniProt", "db_id": "P19681" }, { "db_name": "UniProt", "db_id": "P19974" }, { "db_name": "UniProt", "db_id": "P21665" }, { "db_name": "UniProt", "db_id": "P22342" }, { "db_name": "UniProt", "db_id": "P25400" }, { "db_name": "UniProt", "db_id": "P29380" }, { "db_name": "UniProt", "db_id": "P32556" }, { "db_name": "UniProt", "db_id": "P38091" }, { "db_name": "UniProt", "db_id": "P53698" }, { "db_name": "UniProt", "db_id": "P56205" }, { "db_name": "UniProt", "db_id": "P59218" }, { "db_name": "UniProt", "db_id": "P62772" }, { "db_name": "UniProt", "db_id": "P62773" }, { "db_name": "UniProt", "db_id": "P62894" }, { "db_name": "UniProt", "db_id": "P62895" }, { "db_name": "UniProt", "db_id": "P62896" }, { "db_name": "UniProt", "db_id": "P67881" }, { "db_name": "UniProt", "db_id": "P67882" }, { "db_name": "UniProt", "db_id": "P68096" }, { "db_name": "UniProt", "db_id": "P68097" }, { "db_name": "UniProt", "db_id": "P68098" }, { "db_name": "UniProt", "db_id": "P68099" }, { "db_name": "UniProt", "db_id": "P68100" }, { "db_name": "UniProt", "db_id": "P68517" }, { "db_name": "UniProt", "db_id": "P68518" }, { "db_name": "UniProt", "db_id": "P68519" }, { "db_name": "UniProt", "db_id": "P81280" }, { "db_name": "UniProt", "db_id": "P81459" }, { "db_name": "UniProt", "db_id": "P99998" }, { "db_name": "UniProt", "db_id": "P99999" }, { "db_name": "UniProt", "db_id": "Q41346" }, { "db_name": "UniProt", "db_id": "Q4HVX7" }, { "db_name": "UniProt", "db_id": "Q52V08" }, { "db_name": "UniProt", "db_id": "Q52V09" }, { "db_name": "UniProt", "db_id": "Q52V10" }, { "db_name": "UniProt", "db_id": "Q5RFH4" }, { "db_name": "UniProt", "db_id": "Q640U4" }, { "db_name": "UniProt", "db_id": "Q6C9Q0" }, { "db_name": "UniProt", "db_id": "Q6IQM2" }, { "db_name": "UniProt", "db_id": "Q6Q4H8" }, { "db_name": "UniProt", "db_id": "Q6QLW4" }, { "db_name": "UniProt", "db_id": "Q6WUX8" }, { "db_name": "UniProt", "db_id": "Q753F4" }, { "db_name": "UniProt", "db_id": "Q7YR71" }, { "db_name": "UniProt", "db_id": "Q96VP3" } ] }, { "id": "DS.d1053.s0.e1", "type": "compound", "text": [ "Cu" ], "offsets": [ [ 54, 56 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104815" } ] }, { "id": "DS.d1053.s0.e2", "type": "compound", "text": [ "Cu" ], "offsets": [ [ 79, 81 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104815" } ] }, { "id": "DS.d1053.s0.e3", "type": "compound", "text": [ "Cu" ], "offsets": [ [ 79, 81 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104815" } ] } ]
[]
[]
[ { "id": "DS.d1053.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1053.s0.e1", "arg2_id": "DS.d1053.s0.e0", "normalized": [] } ]
DS.d1054
18775100
[ { "id": "DS.d1054.s0", "type": "", "text": [ "Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients." ], "offsets": [ [ 0, 134 ] ] }, { "id": "DS.d1054.s1", "type": "", "text": [ "The present study explored the effects of flaxseed-derived lignan on inflammatory factors and RBP4 concentrations in type 2 diabetics, who have higher levels of these biomarkers." ], "offsets": [ [ 135, 313 ] ] }, { "id": "DS.d1054.s2", "type": "", "text": [ "No between-treatment differences were found with regard to IL-6 or RBP4 ; though IL-6 0.001 following lignan and placebo treatments, respectively)." ], "offsets": [ [ 314, 461 ] ] } ]
[ { "id": "DS.d1054.s0.e0", "type": "compound", "text": [ "lignan" ], "offsets": [ [ 30, 36 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "261166" } ] }, { "id": "DS.d1054.s0.e1", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 71, 75 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d1054.s0.e2", "type": "protein", "text": [ "protein 4" ], "offsets": [ [ 96, 105 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P09048" }, { "db_name": "UniProt", "db_id": "P69610" }, { "db_name": "UniProt", "db_id": "P69611" } ] }, { "id": "DS.d1054.s1.e0", "type": "compound", "text": [ "lignan" ], "offsets": [ [ 194, 200 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "261166" } ] }, { "id": "DS.d1054.s1.e1", "type": "protein", "text": [ "RBP4" ], "offsets": [ [ 229, 233 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02753" }, { "db_name": "UniProt", "db_id": "P06912" }, { "db_name": "UniProt", "db_id": "P18902" }, { "db_name": "UniProt", "db_id": "P27485" }, { "db_name": "UniProt", "db_id": "P41263" }, { "db_name": "UniProt", "db_id": "P61641" }, { "db_name": "UniProt", "db_id": "Q28369" } ] }, { "id": "DS.d1054.s2.e0", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 373, 377 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d1054.s2.e1", "type": "protein", "text": [ "RBP4" ], "offsets": [ [ 381, 385 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02753" }, { "db_name": "UniProt", "db_id": "P06912" }, { "db_name": "UniProt", "db_id": "P18902" }, { "db_name": "UniProt", "db_id": "P27485" }, { "db_name": "UniProt", "db_id": "P41263" }, { "db_name": "UniProt", "db_id": "P61641" }, { "db_name": "UniProt", "db_id": "Q28369" } ] }, { "id": "DS.d1054.s2.e2", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 395, 399 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d1054.s2.e3", "type": "compound", "text": [ "lignan" ], "offsets": [ [ 416, 422 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "261166" } ] } ]
[]
[]
[ { "id": "DS.d1054.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1054.s0.e0", "arg2_id": "DS.d1054.s0.e1", "normalized": [] }, { "id": "DS.d1054.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1054.s0.e0", "arg2_id": "DS.d1054.s0.e2", "normalized": [] }, { "id": "DS.d1054.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1054.s1.e0", "arg2_id": "DS.d1054.s1.e1", "normalized": [] } ]
DS.d1055
18775460
[ { "id": "DS.d1055.s0", "type": "", "text": [ "These include typical G-protein (Galphaq/11)-coupled cascades, such as activation of phospholipase C (PLC), and subsequent accumulation of inositol-(1,4,5)-triphosphate (IP3), intracellular Ca(2+) mobilization, and activation of protein kinase C." ], "offsets": [ [ 0, 246 ] ] } ]
[ { "id": "DS.d1055.s0.e0", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 190, 194 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d1055.s0.e1", "type": "protein", "text": [ "protein kinase C" ], "offsets": [ [ 229, 245 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13678" }, { "db_name": "UniProt", "db_id": "Q25378" } ] } ]
[]
[]
[]
DS.d1056
18775471
[ { "id": "DS.d1056.s0", "type": "", "text": [ "Here we report the discovery of a series of novel adamantyl carboxamides as selective inhibitors of human 11beta-HSD1 in HEK-293 cells transfected with the HSD11B1 gene." ], "offsets": [ [ 0, 169 ] ] } ]
[ { "id": "DS.d1056.s0.e0", "type": "compound", "text": [ "carboxamides" ], "offsets": [ [ 60, 72 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "713" } ] }, { "id": "DS.d1056.s0.e1", "type": "protein", "text": [ "HSD11B1" ], "offsets": [ [ 156, 163 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P28845" }, { "db_name": "UniProt", "db_id": "P51975" }, { "db_name": "UniProt", "db_id": "Q29608" }, { "db_name": "UniProt", "db_id": "Q6QLL4" }, { "db_name": "UniProt", "db_id": "Q6R0J2" }, { "db_name": "UniProt", "db_id": "Q7M3I4" } ] } ]
[]
[]
[ { "id": "DS.d1056.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1056.s0.e0", "arg2_id": "DS.d1056.s0.e1", "normalized": [] } ]
DS.d1057
18775538
[ { "id": "DS.d1057.s0", "type": "", "text": [ "Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapy." ], "offsets": [ [ 0, 120 ] ] }, { "id": "DS.d1057.s1", "type": "", "text": [ "We investigated whether this allele was associated with elevated Lp(a) and cardiovascular risk in the Women's Health Study, a randomized trial of low-dose aspirin, and whether aspirin reduced cardiovascular risk in minor allele carriers." ], "offsets": [ [ 121, 358 ] ] } ]
[ { "id": "DS.d1057.s0.e0", "type": "protein", "text": [ "apolipoprotein(a)" ], "offsets": [ [ 20, 37 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14417" } ] }, { "id": "DS.d1057.s0.e1", "type": "compound", "text": [ "aspirin" ], "offsets": [ [ 104, 111 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2244" } ] }, { "id": "DS.d1057.s1.e0", "type": "protein", "text": [ "Lp(a)" ], "offsets": [ [ 186, 191 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08519" }, { "db_name": "UniProt", "db_id": "P14417" } ] }, { "id": "DS.d1057.s1.e1", "type": "compound", "text": [ "aspirin" ], "offsets": [ [ 276, 283 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2244" } ] }, { "id": "DS.d1057.s1.e2", "type": "compound", "text": [ "aspirin" ], "offsets": [ [ 297, 304 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2244" } ] } ]
[]
[]
[]
DS.d1058
18775593
[ { "id": "DS.d1058.s0", "type": "", "text": [ "The study was prompted to characterize the B-type esterase activities in the terrestrial snail Xeropicta derbentina and to evaluate its sensitivity to organophosphorus and carbamate pesticides." ], "offsets": [ [ 0, 193 ] ] }, { "id": "DS.d1058.s1", "type": "", "text": [ "Specific cholinesterase and carboxylesterase activities were mainly obtained with acetylthiocholine (K(m)=77.2 mM; V(max)=38.2 mU/mg protein) and 1-naphthyl acetate (K(m)=222 mM, V(max)=1095 mU/mg protein) substrates, respectively." ], "offsets": [ [ 194, 425 ] ] } ]
[ { "id": "DS.d1058.s0.e0", "type": "protein", "text": [ "esterase" ], "offsets": [ [ 50, 58 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P16397" }, { "db_name": "UniProt", "db_id": "P18773" } ] }, { "id": "DS.d1058.s0.e1", "type": "compound", "text": [ "carbamate" ], "offsets": [ [ 172, 181 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "277" } ] }, { "id": "DS.d1058.s1.e0", "type": "protein", "text": [ "cholinesterase" ], "offsets": [ [ 203, 217 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P32749" }, { "db_name": "UniProt", "db_id": "P32750" }, { "db_name": "UniProt", "db_id": "P32751" }, { "db_name": "UniProt", "db_id": "P32752" }, { "db_name": "UniProt", "db_id": "P32753" }, { "db_name": "UniProt", "db_id": "P81908" } ] }, { "id": "DS.d1058.s1.e1", "type": "compound", "text": [ "acetylthiocholine" ], "offsets": [ [ 276, 293 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "20544" } ] }, { "id": "DS.d1058.s1.e2", "type": "compound", "text": [ "1-naphthyl acetate" ], "offsets": [ [ 340, 358 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "13247" } ] } ]
[]
[]
[ { "id": "DS.d1058.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1058.s0.e1", "arg2_id": "DS.d1058.s0.e0", "normalized": [] }, { "id": "DS.d1058.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1058.s1.e1", "arg2_id": "DS.d1058.s1.e0", "normalized": [] }, { "id": "DS.d1058.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1058.s1.e2", "arg2_id": "DS.d1058.s1.e0", "normalized": [] } ]
DS.d1059
18775733
[ { "id": "DS.d1059.s0", "type": "", "text": [ "To distinguish between isoform-specific and context-dependent modulation as possible explanations for this selectivity, the effects of penicillin were evaluated on recombinant GABA(A) receptors expressed in HEK293T cells." ], "offsets": [ [ 0, 221 ] ] } ]
[ { "id": "DS.d1059.s0.e0", "type": "compound", "text": [ "penicillin" ], "offsets": [ [ 135, 145 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5904" } ] }, { "id": "DS.d1059.s0.e1", "type": "protein", "text": [ "GABA(A) receptors" ], "offsets": [ [ 176, 193 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P26714" }, { "db_name": "UniProt", "db_id": "Q08832" }, { "db_name": "UniProt", "db_id": "Q9BLY8" } ] } ]
[]
[]
[ { "id": "DS.d1059.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1059.s0.e0", "arg2_id": "DS.d1059.s0.e1", "normalized": [] } ]
DS.d1060
18775745
[ { "id": "DS.d1060.s0", "type": "", "text": [ "Drosophila responds to detection of diamonopimelic-type microbial peptidoglycan through activation of the immune deficiency (Imd) pathway, a signaling pathway with numerous similarities to the mammalian pro-inflammatory TNF pathway." ], "offsets": [ [ 0, 232 ] ] } ]
[ { "id": "DS.d1060.s0.e0", "type": "compound", "text": [ "peptidoglycan" ], "offsets": [ [ 66, 79 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9816401" } ] }, { "id": "DS.d1060.s0.e1", "type": "protein", "text": [ "TNF" ], "offsets": [ [ 220, 223 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] } ]
[]
[]
[ { "id": "DS.d1060.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1060.s0.e0", "arg2_id": "DS.d1060.s0.e1", "normalized": [] } ]
DS.d1061
18775894
[ { "id": "DS.d1061.s0", "type": "", "text": [ "We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone)." ], "offsets": [ [ 0, 307 ] ] } ]
[ { "id": "DS.d1061.s0.e0", "type": "protein", "text": [ "CRP" ], "offsets": [ [ 58, 61 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19062" }, { "db_name": "UniProt", "db_id": "P02741" }, { "db_name": "UniProt", "db_id": "P02742" }, { "db_name": "UniProt", "db_id": "P08462" }, { "db_name": "UniProt", "db_id": "P18151" }, { "db_name": "UniProt", "db_id": "P21291" }, { "db_name": "UniProt", "db_id": "P41964" }, { "db_name": "UniProt", "db_id": "P47875" }, { "db_name": "UniProt", "db_id": "P49254" }, { "db_name": "UniProt", "db_id": "P49262" }, { "db_name": "UniProt", "db_id": "P52753" }, { "db_name": "UniProt", "db_id": "P67966" }, { "db_name": "UniProt", "db_id": "P67967" }, { "db_name": "UniProt", "db_id": "P97315" }, { "db_name": "UniProt", "db_id": "Q07203" } ] }, { "id": "DS.d1061.s0.e1", "type": "protein", "text": [ "fetuin-A" ], "offsets": [ [ 64, 72 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O70159" }, { "db_name": "UniProt", "db_id": "P02765" }, { "db_name": "UniProt", "db_id": "P12763" }, { "db_name": "UniProt", "db_id": "P24090" }, { "db_name": "UniProt", "db_id": "P29699" }, { "db_name": "UniProt", "db_id": "P29700" }, { "db_name": "UniProt", "db_id": "P29701" }, { "db_name": "UniProt", "db_id": "P80191" }, { "db_name": "UniProt", "db_id": "P97515" }, { "db_name": "UniProt", "db_id": "Q9N2D0" } ] }, { "id": "DS.d1061.s0.e2", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 74, 78 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d1061.s0.e3", "type": "protein", "text": [ "IL-18" ], "offsets": [ [ 80, 85 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19073" }, { "db_name": "UniProt", "db_id": "P70380" }, { "db_name": "UniProt", "db_id": "P97636" }, { "db_name": "UniProt", "db_id": "Q14116" }, { "db_name": "UniProt", "db_id": "Q3ZT29" }, { "db_name": "UniProt", "db_id": "Q5I931" }, { "db_name": "UniProt", "db_id": "Q8QFQ8" }, { "db_name": "UniProt", "db_id": "Q95M33" }, { "db_name": "UniProt", "db_id": "Q9TU73" }, { "db_name": "UniProt", "db_id": "Q9XSQ7" }, { "db_name": "UniProt", "db_id": "Q9XSR0" } ] }, { "id": "DS.d1061.s0.e4", "type": "protein", "text": [ "IL-10" ], "offsets": [ [ 87, 92 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46673" }, { "db_name": "UniProt", "db_id": "O97798" }, { "db_name": "UniProt", "db_id": "P18893" }, { "db_name": "UniProt", "db_id": "P22301" }, { "db_name": "UniProt", "db_id": "P29456" }, { "db_name": "UniProt", "db_id": "P43480" }, { "db_name": "UniProt", "db_id": "P46651" }, { "db_name": "UniProt", "db_id": "P47965" }, { "db_name": "UniProt", "db_id": "P48411" }, { "db_name": "UniProt", "db_id": "P51496" }, { "db_name": "UniProt", "db_id": "P51497" }, { "db_name": "UniProt", "db_id": "P51746" }, { "db_name": "UniProt", "db_id": "P55029" }, { "db_name": "UniProt", "db_id": "P79338" }, { "db_name": "UniProt", "db_id": "Q0Z972" }, { "db_name": "UniProt", "db_id": "Q25BC1" }, { "db_name": "UniProt", "db_id": "Q28374" }, { "db_name": "UniProt", "db_id": "Q29055" }, { "db_name": "UniProt", "db_id": "Q29408" }, { "db_name": "UniProt", "db_id": "Q2PE73" }, { "db_name": "UniProt", "db_id": "Q5Q0V6" }, { "db_name": "UniProt", "db_id": "Q865X4" }, { "db_name": "UniProt", "db_id": "Q8MKG9" }, { "db_name": "UniProt", "db_id": "Q9JHK7" }, { "db_name": "UniProt", "db_id": "Q9TSJ4" }, { "db_name": "UniProt", "db_id": "Q9Z1Y5" } ] }, { "id": "DS.d1061.s0.e5", "type": "compound", "text": [ "calcium, phosphate" ], "offsets": [ [ 162, 180 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24441" }, { "db_name": "PubChem", "db_id": "24456" }, { "db_name": "PubChem", "db_id": "24632" } ] }, { "id": "DS.d1061.s0.e6", "type": "compound", "text": [ "calcium-phosphate" ], "offsets": [ [ 182, 199 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24441" }, { "db_name": "PubChem", "db_id": "24456" }, { "db_name": "PubChem", "db_id": "24632" } ] }, { "id": "DS.d1061.s0.e7", "type": "protein", "text": [ "fibrinogen" ], "offsets": [ [ 218, 228 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P22775" }, { "db_name": "UniProt", "db_id": "P81070" } ] }, { "id": "DS.d1061.s0.e8", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 230, 241 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d1061.s0.e9", "type": "protein", "text": [ "high-density lipoprotein" ], "offsets": [ [ 243, 267 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P81182" } ] }, { "id": "DS.d1061.s0.e10", "type": "protein", "text": [ "parathormone" ], "offsets": [ [ 293, 305 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01270" } ] } ]
[]
[]
[]
DS.d1062
18775944
[ { "id": "DS.d1062.s0", "type": "", "text": [ "Serum 25-hydroxyvitamin D (25-OHD), calcium, alkaline phosphatase and phosphorus were measured." ], "offsets": [ [ 0, 95 ] ] } ]
[ { "id": "DS.d1062.s0.e0", "type": "compound", "text": [ "25-hydroxyvitamin D" ], "offsets": [ [ 6, 25 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5283731" }, { "db_name": "PubChem", "db_id": "6433735" } ] }, { "id": "DS.d1062.s0.e1", "type": "protein", "text": [ "alkaline phosphatase" ], "offsets": [ [ 45, 65 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60109" }, { "db_name": "UniProt", "db_id": "P81800" }, { "db_name": "UniProt", "db_id": "P83456" } ] }, { "id": "DS.d1062.s0.e2", "type": "compound", "text": [ "phosphorus" ], "offsets": [ [ 70, 80 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24404" }, { "db_name": "PubChem", "db_id": "139579" } ] } ]
[]
[]
[]
DS.d1063
18776133
[ { "id": "DS.d1063.s0", "type": "", "text": [ "In the current study, we found that treatment of peripheral blood mononuclear cells with combination IL-2/IL-4 for 48 hours, but not with IL-2 or IL-4 alone, abrogated dexamethasone (DEX)-induced glucocorticoid receptor (GCR)-alpha nuclear translocation in both CD4 (+) and CD8(+) T cells." ], "offsets": [ [ 0, 289 ] ] } ]
[ { "id": "DS.d1063.s0.e0", "type": "compound", "text": [ "dexamethasone" ], "offsets": [ [ 168, 181 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5743" } ] }, { "id": "DS.d1063.s0.e1", "type": "protein", "text": [ "glucocorticoid receptor" ], "offsets": [ [ 196, 219 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O13186" }, { "db_name": "UniProt", "db_id": "O46567" }, { "db_name": "UniProt", "db_id": "O73673" }, { "db_name": "UniProt", "db_id": "P04150" }, { "db_name": "UniProt", "db_id": "P06536" }, { "db_name": "UniProt", "db_id": "P06537" }, { "db_name": "UniProt", "db_id": "P35547" }, { "db_name": "UniProt", "db_id": "P49115" }, { "db_name": "UniProt", "db_id": "P49843" }, { "db_name": "UniProt", "db_id": "P49844" }, { "db_name": "UniProt", "db_id": "P59667" }, { "db_name": "UniProt", "db_id": "P79269" }, { "db_name": "UniProt", "db_id": "P79686" }, { "db_name": "UniProt", "db_id": "Q5R9P5" }, { "db_name": "UniProt", "db_id": "Q6XLJ0" }, { "db_name": "UniProt", "db_id": "Q95267" }, { "db_name": "UniProt", "db_id": "Q9N1U3" } ] }, { "id": "DS.d1063.s0.e2", "type": "protein", "text": [ "CD4" ], "offsets": [ [ 262, 265 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01730" }, { "db_name": "UniProt", "db_id": "P05542" }, { "db_name": "UniProt", "db_id": "P16003" }, { "db_name": "UniProt", "db_id": "P16004" }, { "db_name": "UniProt", "db_id": "P33705" }, { "db_name": "UniProt", "db_id": "P46630" }, { "db_name": "UniProt", "db_id": "P79184" }, { "db_name": "UniProt", "db_id": "P79185" }, { "db_name": "UniProt", "db_id": "Q08336" }, { "db_name": "UniProt", "db_id": "Q08338" }, { "db_name": "UniProt", "db_id": "Q08339" }, { "db_name": "UniProt", "db_id": "Q08340" }, { "db_name": "UniProt", "db_id": "Q29037" }, { "db_name": "UniProt", "db_id": "Q9XS78" } ] } ]
[]
[]
[ { "id": "DS.d1063.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1063.s0.e0", "arg2_id": "DS.d1063.s0.e1", "normalized": [] }, { "id": "DS.d1063.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1063.s0.e0", "arg2_id": "DS.d1063.s0.e2", "normalized": [] } ]
DS.d1064
18776170
[ { "id": "DS.d1064.s0", "type": "", "text": [ "Linear regression analyses showed that cholesterol and phospholipid efflux and cellular apoA-I binding correlated significantly with the ability of ABCA1 to form cell surface lipid domains." ], "offsets": [ [ 0, 189 ] ] } ]
[ { "id": "DS.d1064.s0.e0", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 39, 50 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d1064.s0.e1", "type": "protein", "text": [ "apoA-I" ], "offsets": [ [ 88, 94 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18759" }, { "db_name": "UniProt", "db_id": "O42175" }, { "db_name": "UniProt", "db_id": "O42296" }, { "db_name": "UniProt", "db_id": "O42363" }, { "db_name": "UniProt", "db_id": "P02647" }, { "db_name": "UniProt", "db_id": "P02648" }, { "db_name": "UniProt", "db_id": "P04639" }, { "db_name": "UniProt", "db_id": "P08250" }, { "db_name": "UniProt", "db_id": "P09809" }, { "db_name": "UniProt", "db_id": "P15497" }, { "db_name": "UniProt", "db_id": "P18647" }, { "db_name": "UniProt", "db_id": "P18648" }, { "db_name": "UniProt", "db_id": "P27007" }, { "db_name": "UniProt", "db_id": "P32918" }, { "db_name": "UniProt", "db_id": "P68292" }, { "db_name": "UniProt", "db_id": "P68293" }, { "db_name": "UniProt", "db_id": "Q00623" }, { "db_name": "UniProt", "db_id": "Q91488" }, { "db_name": "UniProt", "db_id": "Q9Z2L4" } ] }, { "id": "DS.d1064.s0.e2", "type": "protein", "text": [ "ABCA1" ], "offsets": [ [ 148, 153 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O95477" } ] } ]
[]
[]
[ { "id": "DS.d1064.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1064.s0.e0", "arg2_id": "DS.d1064.s0.e2", "normalized": [] } ]
DS.d1065
18776171
[ { "id": "DS.d1065.s0", "type": "", "text": [ "Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol." ], "offsets": [ [ 0, 120 ] ] }, { "id": "DS.d1065.s1", "type": "", "text": [ "Inflammation plays a role in trans-10, cis-12 (10,12)-conjugated linoleic acid (CLA)-mediated delipidation and insulin resistance in adipocytes." ], "offsets": [ [ 121, 265 ] ] }, { "id": "DS.d1065.s2", "type": "", "text": [ "Given the anti-inflammatory role of resveratrol (RSV), we hypothesized that RSV would attenuate inflammation and insulin resistance caused by 10,12 CLA in human adipocytes." ], "offsets": [ [ 266, 438 ] ] } ]
[ { "id": "DS.d1065.s0.e0", "type": "compound", "text": [ "Conjugated linoleic acid" ], "offsets": [ [ 0, 24 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280644" }, { "db_name": "PubChem", "db_id": "5282796" } ] }, { "id": "DS.d1065.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 51, 58 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1065.s0.e2", "type": "compound", "text": [ "resveratrol" ], "offsets": [ [ 108, 119 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445154" } ] }, { "id": "DS.d1065.s1.e0", "type": "compound", "text": [ "conjugated linoleic acid" ], "offsets": [ [ 175, 199 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280644" }, { "db_name": "PubChem", "db_id": "5282796" } ] }, { "id": "DS.d1065.s1.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 232, 239 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": 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}, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1065.s2.e0", "type": "compound", "text": [ "resveratrol" ], "offsets": [ [ 302, 313 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445154" } ] }, { "id": "DS.d1065.s2.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 379, 386 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": 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[]
[]
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DS.d1066
18777013
[ { "id": "DS.d1066.s0", "type": "", "text": [ "Near-infrared fluorescence detection of ATP-biotin-mediated phosphoprotein labeling." ], "offsets": [ [ 0, 84 ] ] } ]
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[]
[]
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DS.d1067
18777014
[ { "id": "DS.d1067.s0", "type": "", "text": [ "Wheat germ lipase had a high activity and enantioselectivity only in n-hexane with a high initial water activity (alpha(w) = 0.97), especially with 1-phenylethanol (C 32%, E > 200)." ], "offsets": [ [ 0, 184 ] ] } ]
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[]
[]
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DS.d1068
18777087
[ { "id": "DS.d1068.s0", "type": "", "text": [ "We determined effects of the vasopeptidase inhibitor (VPI) omapatrilat and angiotensin II type 1 receptor (AT(1)R) blocker (ARB) candesartan in rats during healing between day-2 and day-21 after reperfused myocardial infarction (RMI) on left ventricular (LV) remodeling and function, and regional matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-3, inducible-nitric-oxide-synthase (iNOS), oxidant-generating myeloperoxidase (MPO), and cytokines tumor-necrosis-factor (TNF)-alpha, interleukin (IL)-6 and IL-10, and transforming-growth-factor (TGF)-beta(1), and collagens." ], "offsets": [ [ 0, 586 ] ] }, { "id": "DS.d1068.s1", "type": "", "text": [ "The results suggest that modulation of matrix proteases, oxidants, cytokines, and NOSs with omapatrilat and candesartan contribute to reversal of adverse collagen and LV remodeling and attenuation of LV dysfunction during healing after RMI." ], "offsets": [ [ 587, 827 ] ] } ]
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"DS.d1068.s1.e1", "type": "compound", "text": [ "omapatrilat" ], "offsets": [ [ 679, 690 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "656629" } ] }, { "id": "DS.d1068.s1.e2", "type": "compound", "text": [ "candesartan" ], "offsets": [ [ 695, 706 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2541" } ] } ]
[]
[]
[ { "id": "DS.d1068.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1068.s1.e2", "arg2_id": "DS.d1068.s1.e0", "normalized": [] }, { "id": "DS.d1068.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1068.s1.e1", "arg2_id": "DS.d1068.s1.e0", "normalized": [] } ]
DS.d1069
18777088
[ { "id": "DS.d1069.s0", "type": "", "text": [ "We recently reported homocysteine (Hcy)-induced ERK-phosphorylation was suppressed by pertussis toxin (PTX), which suggested the involvement of GPCRs in initiating signal transduction." ], "offsets": [ [ 0, 184 ] ] } ]
[ { "id": "DS.d1069.s0.e0", "type": "compound", "text": [ "homocysteine" ], "offsets": [ [ 21, 33 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "778" } ] }, { "id": "DS.d1069.s0.e1", "type": "protein", "text": [ "ERK" ], "offsets": [ [ 48, 51 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29323" } ] } ]
[]
[]
[ { "id": "DS.d1069.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1069.s0.e0", "arg2_id": "DS.d1069.s0.e1", "normalized": [] } ]
DS.d1070
18777110
[ { "id": "DS.d1070.s0", "type": "", "text": [ "Other factors prognostic for inferior survival were serum albumin 37 g/L (HR 3.22, 95% CI 1.11-13.22, p = 0.034) and treatment with non-cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy (HR 4.89, 95% CI 1.67-14.36, p = 0.004)." ], "offsets": [ [ 0, 250 ] ] } ]
[ { "id": "DS.d1070.s0.e0", "type": "protein", "text": [ "serum albumin" ], "offsets": [ [ 52, 65 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21847" }, { "db_name": "UniProt", "db_id": "P83517" } ] }, { "id": "DS.d1070.s0.e1", "type": "compound", "text": [ "cyclophosphamide" ], "offsets": [ [ 136, 152 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2907" }, { "db_name": "PubChem", "db_id": "9554282" } ] }, { "id": "DS.d1070.s0.e2", "type": "compound", "text": [ "doxorubicin" ], "offsets": [ [ 154, 165 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "31703" } ] }, { "id": "DS.d1070.s0.e3", "type": "compound", "text": [ "vincristine" ], "offsets": [ [ 167, 178 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5978" } ] }, { "id": "DS.d1070.s0.e4", "type": "compound", "text": [ "prednisolone" ], "offsets": [ [ 184, 196 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5755" } ] } ]
[]
[]
[]
DS.d1071
18777117
[ { "id": "DS.d1071.s0", "type": "", "text": [ "Association between Val/Leu (247) polymorphism of apolipoprotein H and cerebral infarction in a Chinese population." ], "offsets": [ [ 0, 115 ] ] }, { "id": "DS.d1071.s1", "type": "", "text": [ "The purpose of this study was to identify associations between the Val/Leu (247) polymorphism of apoH gene and CI in a Chinese cohort." ], "offsets": [ [ 116, 250 ] ] } ]
[ { "id": "DS.d1071.s0.e0", "type": "compound", "text": [ "Val/Leu" ], "offsets": [ [ 20, 27 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "107487" } ] }, { "id": "DS.d1071.s0.e1", "type": "protein", "text": [ "apolipoprotein H" ], "offsets": [ [ 50, 66 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02749" }, { "db_name": "UniProt", "db_id": "P17690" }, { "db_name": "UniProt", "db_id": "P26644" }, { "db_name": "UniProt", "db_id": "P33703" }, { "db_name": "UniProt", "db_id": "Q01339" }, { "db_name": "UniProt", "db_id": "Q95LB0" } ] }, { "id": "DS.d1071.s1.e0", "type": "compound", "text": [ "Val/Leu" ], "offsets": [ [ 183, 190 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "107487" } ] }, { "id": "DS.d1071.s1.e1", "type": "protein", "text": [ "apoH" ], "offsets": [ [ 213, 217 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02749" }, { "db_name": "UniProt", "db_id": "P17690" }, { "db_name": "UniProt", "db_id": "P26644" }, { "db_name": "UniProt", "db_id": "P33703" }, { "db_name": "UniProt", "db_id": "Q01339" }, { "db_name": "UniProt", "db_id": "Q95LB0" } ] } ]
[]
[]
[ { "id": "DS.d1071.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1071.s0.e0", "arg2_id": "DS.d1071.s0.e1", "normalized": [] }, { "id": "DS.d1071.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1071.s1.e0", "arg2_id": "DS.d1071.s1.e1", "normalized": [] } ]
DS.d1072
18777136
[ { "id": "DS.d1072.s0", "type": "", "text": [ "We have discovered multiple genetic and biochemical differences between humans and these other hominids, in relation to sialic acids and in Siglecs (Sia-recognizing Ig superfamily lectins)." ], "offsets": [ [ 0, 189 ] ] } ]
[ { "id": "DS.d1072.s0.e0", "type": "compound", "text": [ "sialic acids" ], "offsets": [ [ 120, 132 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "349960" } ] }, { "id": "DS.d1072.s0.e1", "type": "protein", "text": [ "lectins" ], "offsets": [ [ 180, 187 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02871" }, { "db_name": "UniProt", "db_id": "P02873" }, { "db_name": "UniProt", "db_id": "P02874" }, { "db_name": "UniProt", "db_id": "P02875" }, { "db_name": "UniProt", "db_id": "P07386" }, { "db_name": "UniProt", "db_id": "P16108" }, { "db_name": "UniProt", "db_id": "P16349" }, { "db_name": "UniProt", "db_id": "P16351" }, { "db_name": "UniProt", "db_id": "P16352" }, { "db_name": "UniProt", "db_id": "P33888" }, { "db_name": "UniProt", "db_id": "P38662" }, { "db_name": "UniProt", "db_id": "P42088" }, { "db_name": "UniProt", "db_id": "P83410" }, { "db_name": "UniProt", "db_id": "P83511" }, { "db_name": "UniProt", "db_id": "P84987" }, { "db_name": "UniProt", "db_id": "Q41114" } ] } ]
[]
[]
[]
DS.d1073
18777160
[ { "id": "DS.d1073.s0", "type": "", "text": [ "Possible binding site for the substrate, prostaglandin H(2) (PGH(2)), was identified by systematically probing the refined molecular structure of mPGES-1." ], "offsets": [ [ 0, 154 ] ] } ]
[ { "id": "DS.d1073.s0.e0", "type": "compound", "text": [ "PGH(2" ], "offsets": [ [ 61, 66 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445049" } ] }, { "id": "DS.d1073.s0.e1", "type": "protein", "text": [ "mPGES-1" ], "offsets": [ [ 146, 153 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9JM51" } ] } ]
[]
[]
[ { "id": "DS.d1073.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1073.s0.e0", "arg2_id": "DS.d1073.s0.e1", "normalized": [] } ]
DS.d1074
18777180
[ { "id": "DS.d1074.s0", "type": "", "text": [ "We cloned the zGCAP4 gene, purified non-myristoylated and myristoylated forms of the protein after heterologous expression in Escherichia coli and studied its properties: zGCAP4 was a strong activator of membrane-bound guanylate cyclases from bovine and zebrafish retina, showing half-maximal activation at 520-570 nM free Ca(2+) concentration." ], "offsets": [ [ 0, 344 ] ] }, { "id": "DS.d1074.s1", "type": "", "text": [ "Thus, expression and biochemical properties of zGCAP4 are in agreement with its function as an efficient Ca(2+)-sensitive regulator of guanylate cyclase activity in cone vision." ], "offsets": [ [ 345, 522 ] ] } ]
[ { "id": "DS.d1074.s0.e0", "type": "protein", "text": [ "cyclases" ], "offsets": [ [ 229, 237 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O94303" }, { "db_name": "UniProt", "db_id": "P33734" }, { "db_name": "UniProt", "db_id": "Q9P4P9" }, { "db_name": "UniProt", "db_id": "Q9SZ30" } ] }, { "id": "DS.d1074.s0.e1", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 323, 327 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d1074.s1.e0", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 450, 454 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d1074.s1.e1", "type": "protein", "text": [ "cyclase" ], "offsets": [ [ 490, 497 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O94303" }, { "db_name": "UniProt", "db_id": "P33734" }, { "db_name": "UniProt", "db_id": "Q9P4P9" }, { "db_name": "UniProt", "db_id": "Q9SZ30" } ] } ]
[]
[]
[]
DS.d1075
18777181
[ { "id": "DS.d1075.s0", "type": "", "text": [ "The results of the present work show that this replacement does not considerably affect the DNA modifications by this drug, recognition of these modifications by HMGB1 protein, their repair, and reactivity of the platinum complex with GSH." ], "offsets": [ [ 0, 239 ] ] } ]
[ { "id": "DS.d1075.s0.e0", "type": "protein", "text": [ "HMGB1" ], "offsets": [ [ 162, 167 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07156" }, { "db_name": "UniProt", "db_id": "P09429" }, { "db_name": "UniProt", "db_id": "P10103" }, { "db_name": "UniProt", "db_id": "P12682" }, { "db_name": "UniProt", "db_id": "P36194" }, { "db_name": "UniProt", "db_id": "Q4R844" }, { "db_name": "UniProt", "db_id": "Q6YKA4" } ] }, { "id": "DS.d1075.s0.e1", "type": "compound", "text": [ "platinum complex" ], "offsets": [ [ 213, 229 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2915" } ] }, { "id": "DS.d1075.s0.e2", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 235, 238 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] } ]
[]
[]
[]
DS.d1076
18778244
[ { "id": "DS.d1076.s0", "type": "", "text": [ "However, in addition to GST activity, we discovered that EGST also possesses thiol : disulfide oxidoreductase activity, for which the residue Cys (10) plays an essential role." ], "offsets": [ [ 0, 175 ] ] } ]
[ { "id": "DS.d1076.s0.e0", "type": "protein", "text": [ "GST" ], "offsets": [ [ 24, 27 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20432" }, { "db_name": "UniProt", "db_id": "P30104" }, { "db_name": "UniProt", "db_id": "P30106" }, { "db_name": "UniProt", "db_id": "P30107" }, { "db_name": "UniProt", "db_id": "P30108" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" } ] }, { "id": "DS.d1076.s0.e1", "type": "compound", "text": [ "thiol" ], "offsets": [ [ 77, 82 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "45102689" } ] }, { "id": "DS.d1076.s0.e2", "type": "protein", "text": [ "disulfide oxidoreductase" ], "offsets": [ [ 85, 109 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O84179" }, { "db_name": "UniProt", "db_id": "P0A6M2" }, { "db_name": "UniProt", "db_id": "P0A6M3" }, { "db_name": "UniProt", "db_id": "P44707" }, { "db_name": "UniProt", "db_id": "P59343" }, { "db_name": "UniProt", "db_id": "P59346" }, { "db_name": "UniProt", "db_id": "P59347" }, { "db_name": "UniProt", "db_id": "P63993" }, { "db_name": "UniProt", "db_id": "P63994" }, { "db_name": "UniProt", "db_id": "P94287" }, { "db_name": "UniProt", "db_id": "Q44856" }, { "db_name": "UniProt", "db_id": "Q54155" }, { "db_name": "UniProt", "db_id": "Q56578" }, { "db_name": "UniProt", "db_id": "Q7MJN7" }, { "db_name": "UniProt", "db_id": "Q7VKY2" }, { "db_name": "UniProt", "db_id": "Q822U2" }, { "db_name": "UniProt", "db_id": "Q83D55" }, { "db_name": "UniProt", "db_id": "Q87AV3" }, { "db_name": "UniProt", "db_id": "Q87N03" }, { "db_name": "UniProt", "db_id": "Q887H2" }, { "db_name": "UniProt", "db_id": "Q8ERY3" }, { "db_name": "UniProt", "db_id": "Q8GHM3" }, { "db_name": "UniProt", "db_id": "Q8PC32" }, { "db_name": "UniProt", "db_id": "Q8PNQ6" }, { "db_name": "UniProt", "db_id": "Q8XZM2" }, { "db_name": "UniProt", "db_id": "Q8ZEM1" }, { "db_name": "UniProt", "db_id": "Q9JTA9" }, { "db_name": "UniProt", "db_id": "Q9JYC6" }, { "db_name": "UniProt", "db_id": "Q9KBI6" }, { "db_name": "UniProt", "db_id": "Q9KQU6" }, { "db_name": "UniProt", "db_id": "Q9L6B3" }, { "db_name": "UniProt", "db_id": "Q9PGG2" }, { "db_name": "UniProt", "db_id": "Q9PKL7" }, { "db_name": "UniProt", "db_id": "Q9RWB5" }, { "db_name": "UniProt", "db_id": "Q9Z8V7" } ] } ]
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[]
[]
DS.d1077
18778281
[ { "id": "DS.d1077.s0", "type": "", "text": [ "Anti-P mAb promoted IL-10 overproduction in a dose- and time-dependent manner in both lipopolysaccharide (LPS)-activated RAW 264.7 cells and primary human macrophages." ], "offsets": [ [ 0, 167 ] ] } ]
[ { "id": "DS.d1077.s0.e0", "type": "protein", "text": [ "IL-10" ], "offsets": [ [ 20, 25 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46673" }, { "db_name": "UniProt", "db_id": "O97798" }, { "db_name": "UniProt", "db_id": "P18893" }, { "db_name": "UniProt", "db_id": "P22301" }, { "db_name": "UniProt", "db_id": "P29456" }, { "db_name": "UniProt", "db_id": "P43480" }, { "db_name": "UniProt", "db_id": "P46651" }, { "db_name": "UniProt", "db_id": "P47965" }, { "db_name": "UniProt", "db_id": "P48411" }, { "db_name": "UniProt", "db_id": "P51496" }, { "db_name": "UniProt", "db_id": "P51497" }, { "db_name": "UniProt", "db_id": "P51746" }, { "db_name": "UniProt", "db_id": "P55029" }, { "db_name": "UniProt", "db_id": "P79338" }, { "db_name": "UniProt", "db_id": "Q0Z972" }, { "db_name": "UniProt", "db_id": "Q25BC1" }, { "db_name": "UniProt", "db_id": "Q28374" }, { "db_name": "UniProt", "db_id": "Q29055" }, { "db_name": "UniProt", "db_id": "Q29408" }, { "db_name": "UniProt", "db_id": "Q2PE73" }, { "db_name": "UniProt", "db_id": "Q5Q0V6" }, { "db_name": "UniProt", "db_id": "Q865X4" }, { "db_name": "UniProt", "db_id": "Q8MKG9" }, { "db_name": "UniProt", "db_id": "Q9JHK7" }, { "db_name": "UniProt", "db_id": "Q9TSJ4" }, { "db_name": "UniProt", "db_id": "Q9Z1Y5" } ] }, { "id": "DS.d1077.s0.e1", "type": "compound", "text": [ "lipopolysaccharide" ], "offsets": [ [ 86, 104 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11970143" } ] } ]
[]
[]
[]
DS.d1078
18778289
[ { "id": "DS.d1078.s0", "type": "", "text": [ "Increased secretion of hyperimmune antibodies following lipopolysaccharide stimulation of CD40-activated human B cells in vitro." ], "offsets": [ [ 0, 128 ] ] } ]
[ { "id": "DS.d1078.s0.e0", "type": "compound", "text": [ "lipopolysaccharide" ], "offsets": [ [ 56, 74 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11970143" } ] }, { "id": "DS.d1078.s0.e1", "type": "protein", "text": [ "CD40" ], "offsets": [ [ 90, 94 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25942" }, { "db_name": "UniProt", "db_id": "Q28203" }, { "db_name": "UniProt", "db_id": "Q3LRP1" }, { "db_name": "UniProt", "db_id": "Q3ZTK5" }, { "db_name": "UniProt", "db_id": "Q7YRL5" }, { "db_name": "UniProt", "db_id": "Q8SQ34" } ] } ]
[]
[]
[ { "id": "DS.d1078.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1078.s0.e0", "arg2_id": "DS.d1078.s0.e1", "normalized": [] } ]
DS.d1079
18778316
[ { "id": "DS.d1079.s0", "type": "", "text": [ "The addition of a bisecting N-acetylglucosamine residue by beta(1,4)-N-acetylglucosaminyltransferase III (GnTIII) is known to control the processing of N-linked glycans in mammals, for example by preventing alpha(1,6)-fucosylation of the core glycan." ], "offsets": [ [ 0, 250 ] ] }, { "id": "DS.d1079.s1", "type": "", "text": [ "Both CTSs targeted enhanced yellow fluorescent protein (eYFP) to a brefeldin A-sensitive compartment, indicative of Golgi localization." ], "offsets": [ [ 251, 386 ] ] } ]
[ { "id": "DS.d1079.s0.e0", "type": "compound", "text": [ "N-acetylglucosamine" ], "offsets": [ [ 28, 47 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24139" } ] }, { "id": "DS.d1079.s0.e1", "type": "protein", "text": [ "N-acetylglucosaminyltransferase III" ], "offsets": [ [ 69, 104 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q02527" }, { "db_name": "UniProt", "db_id": "Q09327" }, { "db_name": "UniProt", "db_id": "Q10470" } ] }, { "id": "DS.d1079.s1.e0", "type": "protein", "text": [ "yellow fluorescent protein" ], "offsets": [ [ 279, 305 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21578" } ] }, { "id": "DS.d1079.s1.e1", "type": "compound", "text": [ "brefeldin A" ], "offsets": [ [ 318, 329 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5287620" } ] } ]
[]
[]
[ { "id": "DS.d1079.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1079.s0.e0", "arg2_id": "DS.d1079.s0.e1", "normalized": [] } ]
DS.d1081
18778748
[ { "id": "DS.d1081.s0", "type": "", "text": [ "We have investigated the pre-receptor metabolism of progesterone in primary hOSE cells and an immortalised hOSE cell line, OSE-C2, focusing on transcriptional regulation of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) by inflammatory, anti-inflammatory and apoptotic factors." ], "offsets": [ [ 0, 277 ] ] } ]
[ { "id": "DS.d1081.s0.e0", "type": "compound", "text": [ "progesterone" ], "offsets": [ [ 52, 64 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5994" } ] }, { "id": "DS.d1081.s0.e1", "type": "protein", "text": [ "3beta-hydroxysteroid dehydrogenase" ], "offsets": [ [ 173, 207 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P19871" } ] }, { "id": "DS.d1081.s0.e2", "type": "protein", "text": [ "3beta-HSD" ], "offsets": [ [ 209, 218 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46516" }, { "db_name": "UniProt", "db_id": "O57245" }, { "db_name": "UniProt", "db_id": "P14893" }, { "db_name": "UniProt", "db_id": "P21097" }, { "db_name": "UniProt", "db_id": "P26670" }, { "db_name": "UniProt", "db_id": "P27365" }, { "db_name": "UniProt", "db_id": "Q5IFP1" }, { "db_name": "UniProt", "db_id": "Q67477" }, { "db_name": "UniProt", "db_id": "Q9N119" } ] } ]
[]
[]
[]
DS.d1082
18778749
[ { "id": "DS.d1082.s0", "type": "", "text": [ "Coexpression with H6PDH potentiated 11beta-HSD1 reductase activity at high glucose." ], "offsets": [ [ 0, 83 ] ] }, { "id": "DS.d1082.s1", "type": "", "text": [ "11beta-HSD1 dehydrogenase activity was observed in H4IIE cells only at subphysiological glucose levels, indicating a highly efficient supply of substrate for H6PDH and NADPH generation in the ER-lumen." ], "offsets": [ [ 84, 285 ] ] } ]
[ { "id": "DS.d1082.s0.e0", "type": "protein", "text": [ "11beta-HSD1" ], "offsets": [ [ 36, 47 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P16232" }, { "db_name": "UniProt", "db_id": "P28845" }, { "db_name": "UniProt", "db_id": "P50172" }, { "db_name": "UniProt", "db_id": "P51975" }, { "db_name": "UniProt", "db_id": "Q29608" }, { "db_name": "UniProt", "db_id": "Q6QLL4" }, { "db_name": "UniProt", "db_id": "Q6R0J2" }, { "db_name": "UniProt", "db_id": "Q7M3I4" } ] }, { "id": "DS.d1082.s0.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 75, 82 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1082.s1.e0", "type": "protein", "text": [ "11beta-HSD1" ], "offsets": [ [ 84, 95 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P16232" }, { "db_name": "UniProt", "db_id": "P28845" }, { "db_name": "UniProt", "db_id": "P50172" }, { "db_name": "UniProt", "db_id": "P51975" }, { "db_name": "UniProt", "db_id": "Q29608" }, { "db_name": "UniProt", "db_id": "Q6QLL4" }, { "db_name": "UniProt", "db_id": "Q6R0J2" }, { "db_name": "UniProt", "db_id": "Q7M3I4" } ] }, { "id": "DS.d1082.s1.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 172, 179 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] } ]
[]
[]
[ { "id": "DS.d1082.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1082.s0.e1", "arg2_id": "DS.d1082.s0.e0", "normalized": [] }, { "id": "DS.d1082.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1082.s1.e1", "arg2_id": "DS.d1082.s1.e0", "normalized": [] } ]
DS.d1083
18778768
[ { "id": "DS.d1083.s0", "type": "", "text": [ "There are data to suggest that psychological intervention can influence neuroendocrine (e.g., cortisol) and immune function indicators, especially lymphocyte proliferation and TH1 cytokine production." ], "offsets": [ [ 0, 200 ] ] } ]
[ { "id": "DS.d1083.s0.e0", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 94, 102 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] }, { "id": "DS.d1083.s0.e1", "type": "protein", "text": [ "TH1" ], "offsets": [ [ 176, 179 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q24134" }, { "db_name": "UniProt", "db_id": "Q8IXH7" }, { "db_name": "UniProt", "db_id": "Q9UVI4" } ] } ]
[]
[]
[]
DS.d1084
18778874
[ { "id": "DS.d1084.s0", "type": "", "text": [ "The proteins identified belong to the photosynthesis, carbohydrate and nitrogen metabolism, and stress-related protein functional categories." ], "offsets": [ [ 0, 141 ] ] } ]
[ { "id": "DS.d1084.s0.e0", "type": "compound", "text": [ "nitrogen" ], "offsets": [ [ 71, 79 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "947" }, { "db_name": "PubChem", "db_id": "123329" } ] }, { "id": "DS.d1084.s0.e1", "type": "protein", "text": [ "stress-related protein" ], "offsets": [ [ 96, 118 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q41112" }, { "db_name": "UniProt", "db_id": "Q9SW70" } ] } ]
[]
[]
[]
DS.d1085
18778892
[ { "id": "DS.d1085.s0", "type": "", "text": [ "In the present study, we investigated whether CD147/basigin is involved, via its association with MCT1 and 4 to transport lactate, in glycolysis and then contributes to the progression of A375 melanoma cells." ], "offsets": [ [ 0, 208 ] ] } ]
[ { "id": "DS.d1085.s0.e0", "type": "protein", "text": [ "basigin" ], "offsets": [ [ 52, 59 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q99PA3" } ] }, { "id": "DS.d1085.s0.e1", "type": "protein", "text": [ "MCT1" ], "offsets": [ [ 98, 102 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35439" }, { "db_name": "UniProt", "db_id": "P53985" }, { "db_name": "UniProt", "db_id": "Q03064" }, { "db_name": "UniProt", "db_id": "Q12283" } ] }, { "id": "DS.d1085.s0.e2", "type": "compound", "text": [ "lactate" ], "offsets": [ [ 122, 129 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "612" } ] } ]
[]
[]
[ { "id": "DS.d1085.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1085.s0.e2", "arg2_id": "DS.d1085.s0.e1", "normalized": [] }, { "id": "DS.d1085.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1085.s0.e2", "arg2_id": "DS.d1085.s0.e0", "normalized": [] } ]
DS.d1086
18779389
[ { "id": "DS.d1086.s0", "type": "", "text": [ "TCblR belongs to the low-density lipoprotein receptor family, with 2 low-density lipoprotein receptor type A domains separated by a complement-like cysteine-rich region." ], "offsets": [ [ 0, 169 ] ] } ]
[ { "id": "DS.d1086.s0.e0", "type": "protein", "text": [ "low-density lipoprotein receptor" ], "offsets": [ [ 21, 53 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01131" }, { "db_name": "UniProt", "db_id": "P20063" }, { "db_name": "UniProt", "db_id": "Q28832" } ] }, { "id": "DS.d1086.s0.e1", "type": "protein", "text": [ "type A" ], "offsets": [ [ 102, 108 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02855" } ] }, { "id": "DS.d1086.s0.e2", "type": "compound", "text": [ "cysteine" ], "offsets": [ [ 148, 156 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "594" }, { "db_name": "PubChem", "db_id": "5862" }, { "db_name": "PubChem", "db_id": "5360637" } ] } ]
[]
[]
[ { "id": "DS.d1086.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1086.s0.e2", "arg2_id": "DS.d1086.s0.e0", "normalized": [] }, { "id": "DS.d1086.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1086.s0.e2", "arg2_id": "DS.d1086.s0.e1", "normalized": [] } ]
DS.d1087
18780301
[ { "id": "DS.d1087.s0", "type": "", "text": [ "Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine." ], "offsets": [ [ 0, 165 ] ] } ]
[ { "id": "DS.d1087.s0.e0", "type": "protein", "text": [ "AChE" ], "offsets": [ [ 15, 19 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42275" }, { "db_name": "UniProt", "db_id": "O62763" }, { "db_name": "UniProt", "db_id": "P04058" }, { "db_name": "UniProt", "db_id": "P07140" }, { "db_name": "UniProt", "db_id": "P07692" }, { "db_name": "UniProt", "db_id": "P21836" }, { "db_name": "UniProt", "db_id": "P22303" }, { "db_name": "UniProt", "db_id": "P23795" }, { "db_name": "UniProt", "db_id": "P36196" }, { "db_name": "UniProt", "db_id": "P37136" }, { "db_name": "UniProt", "db_id": "P56161" }, { "db_name": "UniProt", "db_id": "Q27677" }, { "db_name": "UniProt", "db_id": "Q29499" }, { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q869C3" }, { "db_name": "UniProt", "db_id": "Q86GC8" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92035" }, { "db_name": "UniProt", "db_id": "Q92081" }, { "db_name": "UniProt", "db_id": "Q9DDE3" } ] }, { "id": "DS.d1087.s0.e1", "type": "protein", "text": [ "ChAT" ], "offsets": [ [ 31, 35 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07668" }, { "db_name": "UniProt", "db_id": "P13222" }, { "db_name": "UniProt", "db_id": "P28329" }, { "db_name": "UniProt", "db_id": "P32738" }, { "db_name": "UniProt", "db_id": "P32756" }, { "db_name": "UniProt", "db_id": "Q03059" } ] }, { "id": "DS.d1087.s0.e2", "type": "compound", "text": [ "Donepezil" ], "offsets": [ [ 138, 147 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3152" } ] }, { "id": "DS.d1087.s0.e3", "type": "compound", "text": [ "Rivastigmine" ], "offsets": [ [ 152, 164 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "77991" } ] } ]
[]
[]
[ { "id": "DS.d1087.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1087.s0.e2", "arg2_id": "DS.d1087.s0.e1", "normalized": [] }, { "id": "DS.d1087.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1087.s0.e3", "arg2_id": "DS.d1087.s0.e1", "normalized": [] }, { "id": "DS.d1087.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1087.s0.e3", "arg2_id": "DS.d1087.s0.e0", "normalized": [] }, { "id": "DS.d1087.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1087.s0.e2", "arg2_id": "DS.d1087.s0.e0", "normalized": [] } ]
DS.d1088
18780328
[ { "id": "DS.d1088.s0", "type": "", "text": [ "Extended-release PEG-luciferin allows for long-term imaging of firefly luciferase activity in vivo." ], "offsets": [ [ 0, 99 ] ] } ]
[ { "id": "DS.d1088.s0.e0", "type": "compound", "text": [ "luciferin" ], "offsets": [ [ 21, 30 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5484207" } ] }, { "id": "DS.d1088.s0.e1", "type": "protein", "text": [ "luciferase" ], "offsets": [ [ 71, 81 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08659" }, { "db_name": "UniProt", "db_id": "P13129" }, { "db_name": "UniProt", "db_id": "Q01158" }, { "db_name": "UniProt", "db_id": "Q26304" }, { "db_name": "UniProt", "db_id": "Q27757" } ] } ]
[]
[]
[ { "id": "DS.d1088.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1088.s0.e0", "arg2_id": "DS.d1088.s0.e1", "normalized": [] } ]
DS.d1089
18780332
[ { "id": "DS.d1089.s0", "type": "", "text": [ "Spectrofluorimetric determination of vitamin B(1) using horseradish peroxidase as catalyst in the presence of hydrogen peroxide." ], "offsets": [ [ 0, 128 ] ] }, { "id": "DS.d1089.s1", "type": "", "text": [ "In this work a new spectrofluorimetric method for the determination of vitamin B(1), based on the catalytic activity of horseradish peroxidase (HRP) in the presence of hydrogen peroxide (H2O2), has been developed." ], "offsets": [ [ 129, 342 ] ] } ]
[ { "id": "DS.d1089.s0.e0", "type": "protein", "text": [ "peroxidase" ], "offsets": [ [ 68, 78 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15984" }, { "db_name": "UniProt", "db_id": "P16147" }, { "db_name": "UniProt", "db_id": "P84714" } ] }, { "id": "DS.d1089.s0.e1", "type": "compound", "text": [ "hydrogen peroxide" ], "offsets": [ [ 110, 127 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "784" } ] }, { "id": "DS.d1089.s1.e0", "type": "protein", "text": [ "peroxidase" ], "offsets": [ [ 261, 271 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15984" }, { "db_name": "UniProt", "db_id": "P16147" }, { "db_name": "UniProt", "db_id": "P84714" } ] }, { "id": "DS.d1089.s1.e1", "type": "protein", "text": [ "HRP" ], "offsets": [ [ 273, 276 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q08168" } ] }, { "id": "DS.d1089.s1.e2", "type": "compound", "text": [ "hydrogen peroxide" ], "offsets": [ [ 297, 314 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "784" } ] }, { "id": "DS.d1089.s1.e3", "type": "compound", "text": [ "H2O2" ], "offsets": [ [ 316, 320 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "784" } ] } ]
[]
[]
[ { "id": "DS.d1089.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1089.s0.e1", "arg2_id": "DS.d1089.s0.e0", "normalized": [] }, { "id": "DS.d1089.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1089.s1.e3", "arg2_id": "DS.d1089.s1.e1", "normalized": [] }, { "id": "DS.d1089.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1089.s1.e3", "arg2_id": "DS.d1089.s1.e0", "normalized": [] }, { "id": "DS.d1089.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1089.s1.e2", "arg2_id": "DS.d1089.s1.e1", "normalized": [] }, { "id": "DS.d1089.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1089.s1.e2", "arg2_id": "DS.d1089.s1.e0", "normalized": [] } ]
DS.d1090
18780360
[ { "id": "DS.d1090.s0", "type": "", "text": [ "Electrospun polyglyconate (Maxon) and its blends with proteins such as gelatin and elastin, with a spatially designed layer structure, were prepared as potential scaffolds for vascular tissue engineering." ], "offsets": [ [ 0, 204 ] ] } ]
[ { "id": "DS.d1090.s0.e0", "type": "compound", "text": [ "polyglyconate" ], "offsets": [ [ 12, 25 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "123833" } ] }, { "id": "DS.d1090.s0.e1", "type": "compound", "text": [ "Maxon" ], "offsets": [ [ 27, 32 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "123833" } ] }, { "id": "DS.d1090.s0.e2", "type": "protein", "text": [ "elastin" ], "offsets": [ [ 83, 90 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11547" } ] } ]
[]
[]
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DS.d1091
18781168
[ { "id": "DS.d1091.s0", "type": "", "text": [ "So far, in maize, three classes of mutants involved in phytic acid biosynthesis have been isolated: lpa1, lpa2 and lpa3." ], "offsets": [ [ 0, 120 ] ] } ]
[ { "id": "DS.d1091.s0.e0", "type": "compound", "text": [ "phytic acid" ], "offsets": [ [ 55, 66 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "890" } ] }, { "id": "DS.d1091.s0.e1", "type": "protein", "text": [ "lpa1" ], "offsets": [ [ 100, 104 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P61793" }, { "db_name": "UniProt", "db_id": "P61794" } ] }, { "id": "DS.d1091.s0.e2", "type": "protein", "text": [ "lpa2" ], "offsets": [ [ 106, 110 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9JL06" } ] }, { "id": "DS.d1091.s0.e3", "type": "protein", "text": [ "lpa3" ], "offsets": [ [ 115, 119 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8K5E0" }, { "db_name": "UniProt", "db_id": "Q9EQ31" } ] } ]
[]
[]
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DS.d1092
18781316
[ { "id": "DS.d1092.s0", "type": "", "text": [ "Bevacizumab (Avastin), ranibizumab (Lucentis) and pegaptanib sodium (Macugen) are anti-VEGF medications that have been used in the treatment of CNV." ], "offsets": [ [ 0, 148 ] ] } ]
[ { "id": "DS.d1092.s0.e0", "type": "compound", "text": [ "pegaptanib sodium" ], "offsets": [ [ 50, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "158786" } ] }, { "id": "DS.d1092.s0.e1", "type": "compound", "text": [ "Macugen" ], "offsets": [ [ 69, 76 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "158786" } ] }, { "id": "DS.d1092.s0.e2", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 87, 91 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] } ]
[]
[]
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DS.d1093
18781338
[ { "id": "DS.d1093.s0", "type": "", "text": [ "Blood samples were collected to assay for biomarkers of oxidative stress (malondialdehyde and carbonyl groups) and antioxidants (glutathione peroxidase, reduced glutathione, alpha-tocopherol, and beta-carotene)." ], "offsets": [ [ 0, 211 ] ] } ]
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[]
[]
[]
DS.d1094
18781385
[ { "id": "DS.d1094.s0", "type": "", "text": [ "The low content of sphingomyelin, sulfatide and galactosylceramide is consistent with the immunohistochemical results showing that in the grey-lethal brain significant depletion and disorganization of the myelinated fibres is present, thus supporting the hypothesis that loss of function of the OSTM1 causes neuronal impairment and myelin deficit." ], "offsets": [ [ 0, 347 ] ] } ]
[ { "id": "DS.d1094.s0.e0", "type": "compound", "text": [ "galactosylceramide" ], "offsets": [ [ 48, 66 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "52949283" } ] }, { "id": "DS.d1094.s0.e1", "type": "protein", "text": [ "OSTM1" ], "offsets": [ [ 295, 300 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q86WC4" } ] } ]
[]
[]
[]
DS.d1095
18781596
[ { "id": "DS.d1095.s0", "type": "", "text": [ "Finally and most importantly, our data indicate that a decrease in AKT activity followed by a total decrease in p70 (S6K) phosphorylation reflecting a decrease in mTOR activity occurs during high oxygen consumption, resulting from high cell density." ], "offsets": [ [ 0, 249 ] ] } ]
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[]
[]
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DS.d1096
18781650
[ { "id": "DS.d1096.s0", "type": "", "text": [ "Some of the peptide derivatives inhibited PEPT1-mediated uptake of ((3)H) Gly-Sar." ], "offsets": [ [ 0, 82 ] ] } ]
[ { "id": "DS.d1096.s0.e0", "type": "protein", "text": [ "PEPT1" ], "offsets": [ [ 42, 47 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P36836" }, { "db_name": "UniProt", "db_id": "P46059" }, { "db_name": "UniProt", "db_id": "Q8WMX5" } ] }, { "id": "DS.d1096.s0.e1", "type": "compound", "text": [ "Gly" ], "offsets": [ [ 74, 77 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "750" }, { "db_name": "PubChem", "db_id": "5460845" } ] } ]
[]
[]
[ { "id": "DS.d1096.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1096.s0.e1", "arg2_id": "DS.d1096.s0.e0", "normalized": [] } ]
DS.d1097
18781688
[ { "id": "DS.d1097.s0", "type": "", "text": [ "Effect of enzyme supplementation at moderate cellulase loadings on initial glucose and xylose release from corn stover solids pretreated by leading technologies." ], "offsets": [ [ 0, 161 ] ] }, { "id": "DS.d1097.s1", "type": "", "text": [ "For a combined mass loading of cellulase and beta-glucosidase of 16.1 mg/g original glucan (about 7.5 FPU/g), glucose release from pretreated solids ranged from 50% to75% of the theoretical maximum and was greater for all pretreatments at all protein loadings compared to pure Avicel cellulose except for solids from controlled pH pretreatment and from dilute acid pretreatment by the Sunds pilot unit." ], "offsets": [ [ 162, 564 ] ] } ]
[ { "id": "DS.d1097.s0.e0", "type": "protein", "text": [ "cellulase" ], "offsets": [ [ 45, 54 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07981" }, { "db_name": "UniProt", "db_id": "P07982" }, { "db_name": "UniProt", "db_id": "P07983" }, { "db_name": "UniProt", "db_id": "P10474" }, { "db_name": "UniProt", "db_id": "P10475" }, { "db_name": "UniProt", "db_id": "P10476" }, { "db_name": "UniProt", "db_id": "P13933" }, { "db_name": "UniProt", "db_id": "P15329" }, { "db_name": "UniProt", "db_id": "P15704" }, { "db_name": "UniProt", "db_id": "P16216" }, { "db_name": "UniProt", "db_id": "P17974" }, { "db_name": "UniProt", "db_id": "P18126" }, { "db_name": "UniProt", "db_id": "P18336" }, { "db_name": "UniProt", "db_id": "P19487" }, { "db_name": "UniProt", "db_id": "P21833" }, { "db_name": "UniProt", "db_id": "P21834" }, { "db_name": "UniProt", "db_id": "P22533" }, { "db_name": "UniProt", "db_id": "P22669" }, { "db_name": "UniProt", "db_id": "P22699" }, { "db_name": "UniProt", "db_id": "P23548" }, { "db_name": "UniProt", "db_id": "P23549" }, { "db_name": "UniProt", "db_id": "P23665" }, { "db_name": "UniProt", "db_id": "P27035" }, { "db_name": "UniProt", "db_id": "P29019" }, { "db_name": "UniProt", "db_id": "P37651" }, { "db_name": "UniProt", "db_id": "P37696" }, { "db_name": "UniProt", "db_id": "P45699" }, { "db_name": "UniProt", "db_id": "P46236" }, { "db_name": "UniProt", "db_id": "P46237" }, { "db_name": "UniProt", "db_id": "P46239" }, { "db_name": "UniProt", "db_id": "P58599" }, { "db_name": "UniProt", "db_id": "P58935" }, { "db_name": "UniProt", "db_id": "P81190" }, { "db_name": "UniProt", "db_id": "P82186" }, { "db_name": "UniProt", "db_id": "P84194" }, { "db_name": "UniProt", "db_id": "P84196" }, { "db_name": "UniProt", "db_id": "Q05622" }, { "db_name": "UniProt", "db_id": "Q12622" }, { "db_name": "UniProt", "db_id": "Q12714" }, { "db_name": "UniProt", "db_id": "Q8RSY9" }, { "db_name": "UniProt", "db_id": "Q8X5L9" }, { "db_name": "UniProt", "db_id": "Q8Z289" }, { "db_name": "UniProt", "db_id": "Q8ZLB7" } ] }, { "id": "DS.d1097.s0.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 75, 82 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5793" } ] }, { "id": "DS.d1097.s1.e0", "type": "protein", "text": [ "cellulase" ], "offsets": [ [ 193, 202 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07981" }, { "db_name": "UniProt", "db_id": "P07982" }, { "db_name": "UniProt", "db_id": "P07983" }, { "db_name": "UniProt", "db_id": "P10474" }, { "db_name": "UniProt", "db_id": "P10475" }, { "db_name": "UniProt", "db_id": "P10476" }, { "db_name": "UniProt", "db_id": "P13933" }, { "db_name": "UniProt", "db_id": "P15329" }, { "db_name": "UniProt", "db_id": "P15704" }, { "db_name": "UniProt", "db_id": "P16216" }, { "db_name": "UniProt", "db_id": "P17974" }, { "db_name": "UniProt", "db_id": "P18126" }, { "db_name": "UniProt", "db_id": "P18336" }, { "db_name": "UniProt", "db_id": "P19487" }, { "db_name": "UniProt", "db_id": "P21833" }, { "db_name": "UniProt", "db_id": "P21834" }, { "db_name": "UniProt", "db_id": "P22533" }, { "db_name": "UniProt", "db_id": "P22669" }, { "db_name": "UniProt", "db_id": "P22699" }, { "db_name": "UniProt", "db_id": "P23548" }, { "db_name": "UniProt", "db_id": "P23549" }, { "db_name": "UniProt", "db_id": "P23665" }, { "db_name": "UniProt", "db_id": "P27035" }, { "db_name": "UniProt", "db_id": "P29019" }, { "db_name": "UniProt", "db_id": "P37651" }, { "db_name": "UniProt", "db_id": "P37696" }, { "db_name": "UniProt", "db_id": "P45699" }, { "db_name": "UniProt", "db_id": "P46236" }, { "db_name": "UniProt", "db_id": "P46237" }, { "db_name": "UniProt", "db_id": "P46239" }, { "db_name": "UniProt", "db_id": "P58599" }, { "db_name": "UniProt", "db_id": "P58935" }, { "db_name": "UniProt", "db_id": "P81190" }, { "db_name": "UniProt", "db_id": "P82186" }, { "db_name": "UniProt", "db_id": "P84194" }, { "db_name": "UniProt", "db_id": "P84196" }, { "db_name": "UniProt", "db_id": "Q05622" }, { "db_name": "UniProt", "db_id": "Q12622" }, { "db_name": "UniProt", "db_id": "Q12714" }, { "db_name": "UniProt", "db_id": "Q8RSY9" }, { "db_name": "UniProt", "db_id": "Q8X5L9" }, { "db_name": "UniProt", "db_id": "Q8Z289" }, { "db_name": "UniProt", "db_id": "Q8ZLB7" } ] }, { "id": "DS.d1097.s1.e1", "type": "protein", "text": [ "beta-glucosidase" ], "offsets": [ [ 207, 223 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P12614" }, { "db_name": "UniProt", "db_id": "P15885" }, { "db_name": "UniProt", "db_id": "P27034" }, { "db_name": "UniProt", "db_id": "P29091" }, { "db_name": "UniProt", "db_id": "P40740" }, { "db_name": "UniProt", "db_id": "Q03506" }, { "db_name": "UniProt", "db_id": "Q46684" } ] }, { "id": "DS.d1097.s1.e2", "type": "compound", "text": [ "glucan" ], "offsets": [ [ 246, 252 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5793" } ] }, { "id": "DS.d1097.s1.e3", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 272, 279 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5793" } ] } ]
[]
[]
[ { "id": "DS.d1097.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1097.s1.e2", "arg2_id": "DS.d1097.s1.e1", "normalized": [] }, { "id": "DS.d1097.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1097.s1.e3", "arg2_id": "DS.d1097.s1.e1", "normalized": [] }, { "id": "DS.d1097.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1097.s1.e2", "arg2_id": "DS.d1097.s1.e0", "normalized": [] }, { "id": "DS.d1097.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1097.s1.e3", "arg2_id": "DS.d1097.s1.e0", "normalized": [] } ]
DS.d1098
18782461
[ { "id": "DS.d1098.s0", "type": "", "text": [ "PCFT/HCP1 could therefore play a physiological role in Fe nutrition and the data highlight the potential for the interaction of folate and haem at the level of intestinal absorption." ], "offsets": [ [ 0, 182 ] ] } ]
[ { "id": "DS.d1098.s0.e0", "type": "protein", "text": [ "HCP1" ], "offsets": [ [ 5, 9 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q13946" }, { "db_name": "UniProt", "db_id": "Q96NT5" } ] }, { "id": "DS.d1098.s0.e1", "type": "compound", "text": [ "folate" ], "offsets": [ [ 128, 134 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6037" } ] } ]
[]
[]
[ { "id": "DS.d1098.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1098.s0.e1", "arg2_id": "DS.d1098.s0.e0", "normalized": [] } ]
DS.d1099
18782463
[ { "id": "DS.d1099.s0", "type": "", "text": [ "Following an oral glucose challenge, there was a weak trend for glucose-stimulated insulin release to be increased in the offspring of dams fed the folate-deficient diet." ], "offsets": [ [ 0, 170 ] ] } ]
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[]
[]
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DS.d1100
18782570
[ { "id": "DS.d1100.s0", "type": "", "text": [ "Association between serum retinol-binding protein 4 and small dense low-density lipoprotein cholesterol levels in young adult women." ], "offsets": [ [ 0, 132 ] ] } ]
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[]
[]
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DS.d1101
18782588
[ { "id": "DS.d1101.s0", "type": "", "text": [ "Adult female X. laevis were injected three times at weekly intervals with the hapten-carrier complex, trinitrophenylated bovine serum albumin (TNP-BSA)." ], "offsets": [ [ 0, 152 ] ] } ]
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[]
[]
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DS.d1102
18782661
[ { "id": "DS.d1102.s0", "type": "", "text": [ "By using the system, we obtained four event timing data sets (stimulation by NGF with and without staurosporine at the concentrations of 0.01, 0.1, and 1 microM)." ], "offsets": [ [ 0, 162 ] ] } ]
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[]
[]
[]
DS.d1103
18783254
[ { "id": "DS.d1103.s1", "type": "", "text": [ "First, R-state, or allosteric, autocatalysis of nitrite reduction increases the rate of NO generation by deoxyhemoglobin and results in maximal NO production at approximately 50% hemoglobin oxygen saturation, which is physiologically associated with greatest NO-dependent vasodilation." ], "offsets": [ [ 0, 285 ] ] } ]
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[]
[]
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DS.d1104
18783311
[ { "id": "DS.d1104.s0", "type": "", "text": [ "Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells." ], "offsets": [ [ 0, 124 ] ] }, { "id": "DS.d1104.s1", "type": "", "text": [ "Downregulation of Nox4, or pretreatment with N-acetylcysteine, attenuated hyperoxia-induced cell migration and capillary tube formation, suggesting that ROS generated by Nox4 regulate endothelial cell motility." ], "offsets": [ [ 125, 335 ] ] } ]
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[]
[]
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DS.d1105
18783384
[ { "id": "DS.d1105.s0", "type": "", "text": [ "Using newly designed degenerate primers targeting the phnA gene we analysed the potential for phosphonoacetate utilization in DNA and cDNA libraries constructed from a phytoplankton bloom in the Western English Channel during July 2006." ], "offsets": [ [ 0, 236 ] ] } ]
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[]
[]
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DS.d1106
18783774
[ { "id": "DS.d1106.s0", "type": "", "text": [ "Low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort study: The Suita study." ], "offsets": [ [ 0, 176 ] ] }, { "id": "DS.d1106.s1", "type": "", "text": [ "Only a small number of population-based cohort studies have directly compared the predictive value of low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDLC) for coronary artery disease in Asian populations, such as Japan." ], "offsets": [ [ 177, 443 ] ] } ]
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[]
[]
[]
DS.d1107
18783827
[ { "id": "DS.d1107.s0", "type": "", "text": [ "Finally, we show that Vcx1 helps return cytosolic Ca(2+) toward resting levels after shock with high extracellular Ca(2+) much more effectively than Pmc1 and that calcineurin, a protein phosphatase regulator of Vcx1 and Pmc1, had no detectable effects on these factors within the first few minutes of its activation." ], "offsets": [ [ 0, 316 ] ] } ]
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[]
[]
[]
DS.d1108
18783828
[ { "id": "DS.d1108.s0", "type": "", "text": [ "It is a serious problem that effective treatment choices to T315I, in the ABL kinase domain that shows a strong tolerance in imatinib do not exist clinically." ], "offsets": [ [ 0, 158 ] ] } ]
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[]
[]
[ { "id": "DS.d1108.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1108.s0.e1", "arg2_id": "DS.d1108.s0.e0", "normalized": [] } ]
DS.d1109
18783846
[ { "id": "DS.d1109.s0", "type": "", "text": [ "Moreover, diacylgycerol-dependent protein kinase C isoenzymes and activation of extracellular signal-regulated protein kinase (ERK) are required for glucose-, tolbutamide- and KCl-induced Egr-1 expression." ], "offsets": [ [ 0, 205 ] ] } ]
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[]
[]
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DS.d1110
18784063
[ { "id": "DS.d1110.s0", "type": "", "text": [ "Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance." ], "offsets": [ [ 0, 157 ] ] } ]
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[]
[]
[ { "id": "DS.d1110.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1110.s0.e1", "arg2_id": "DS.d1110.s0.e2", "normalized": [] }, { "id": "DS.d1110.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1110.s0.e0", "arg2_id": "DS.d1110.s0.e2", "normalized": [] } ]
DS.d1111
18784648
[ { "id": "DS.d1111.s0", "type": "", "text": [ "Glucocorticoid receptor blockade normalizes hippocampal alterations and cognitive impairment in streptozotocin-induced type 1 diabetes mice." ], "offsets": [ [ 0, 140 ] ] } ]
[ { "id": "DS.d1111.s0.e0", "type": "protein", "text": [ "Glucocorticoid receptor" ], "offsets": [ [ 0, 23 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O13186" }, { "db_name": "UniProt", "db_id": "O46567" }, { "db_name": "UniProt", "db_id": "O73673" }, { "db_name": "UniProt", "db_id": "P04150" }, { "db_name": "UniProt", "db_id": "P06536" }, { "db_name": "UniProt", "db_id": "P06537" }, { "db_name": "UniProt", "db_id": "P35547" }, { "db_name": "UniProt", "db_id": "P49115" }, { "db_name": "UniProt", "db_id": "P49843" }, { "db_name": "UniProt", "db_id": "P49844" }, { "db_name": "UniProt", "db_id": "P59667" }, { "db_name": "UniProt", "db_id": "P79269" }, { "db_name": "UniProt", "db_id": "P79686" }, { "db_name": "UniProt", "db_id": "Q5R9P5" }, { "db_name": "UniProt", "db_id": "Q6XLJ0" }, { "db_name": "UniProt", "db_id": "Q95267" }, { "db_name": "UniProt", "db_id": "Q9N1U3" } ] }, { "id": "DS.d1111.s0.e1", "type": "compound", "text": [ "streptozotocin" ], "offsets": [ [ 96, 110 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5300" }, { "db_name": "PubChem", "db_id": "29327" }, { "db_name": "PubChem", "db_id": "6420074" }, { "db_name": "PubChem", "db_id": "6713972" }, { "db_name": "PubChem", "db_id": "7067772" }, { "db_name": "PubChem", "db_id": "45357367" } ] } ]
[]
[]
[ { "id": "DS.d1111.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1111.s0.e1", "arg2_id": "DS.d1111.s0.e0", "normalized": [] } ]
DS.d1112
18784734
[ { "id": "DS.d1112.s0", "type": "", "text": [ "The study aim was to determine whether urine albumin/creatinine ratio (UACR), high-sensitivity C-reactive protein (hsCRP) or N-terminal pro-brain natriuretic peptide (Nt-proBNP) added to risk prediction based on HeartScore and history of diabetes or cardiovascular disease." ], "offsets": [ [ 0, 273 ] ] } ]
[ { "id": "DS.d1112.s0.e0", "type": "compound", "text": [ "creatinine" ], "offsets": [ [ 53, 63 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "588" } ] }, { "id": "DS.d1112.s0.e1", "type": "protein", "text": [ "brain natriuretic peptide" ], "offsets": [ [ 140, 165 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P40753" } ] } ]
[]
[]
[]
DS.d1113
18784749
[ { "id": "DS.d1113.s0", "type": "", "text": [ "Transgene optimization significantly improves SIN vector titers, gp91phox expression and reconstitution of superoxide production in X-CGD cells." ], "offsets": [ [ 0, 144 ] ] } ]
[ { "id": "DS.d1113.s0.e0", "type": "protein", "text": [ "gp91phox" ], "offsets": [ [ 65, 73 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46522" }, { "db_name": "UniProt", "db_id": "P04839" }, { "db_name": "UniProt", "db_id": "P52649" }, { "db_name": "UniProt", "db_id": "Q61093" }, { "db_name": "UniProt", "db_id": "Q95L74" } ] }, { "id": "DS.d1113.s0.e1", "type": "compound", "text": [ "superoxide" ], "offsets": [ [ 107, 117 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5359597" } ] } ]
[]
[]
[]
DS.d1114
18784906
[ { "id": "DS.d1114.s0", "type": "", "text": [ "Quantitative evaluation of PEPT1 contribution to oral absorption of cephalexin in rats." ], "offsets": [ [ 0, 87 ] ] } ]
[ { "id": "DS.d1114.s0.e0", "type": "protein", "text": [ "PEPT1" ], "offsets": [ [ 27, 32 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P36836" }, { "db_name": "UniProt", "db_id": "P46059" }, { "db_name": "UniProt", "db_id": "Q8WMX5" } ] }, { "id": "DS.d1114.s0.e1", "type": "compound", "text": [ "cephalexin" ], "offsets": [ [ 68, 78 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "27447" } ] } ]
[]
[]
[ { "id": "DS.d1114.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1114.s0.e1", "arg2_id": "DS.d1114.s0.e0", "normalized": [] } ]
DS.d1115
18784908
[ { "id": "DS.d1115.s0", "type": "", "text": [ "Cu concentration in the liver and in plasma alanine aminotransferase (ALT) and aspartate transaminase (AST) activities were determined." ], "offsets": [ [ 0, 135 ] ] }, { "id": "DS.d1115.s1", "type": "", "text": [ "In brain tissue, Cu concentration, superoxide dismutase (SOD) activities, malondialdehyde (MDA) levels and glutathione (GSH) concentrations were determined." ], "offsets": [ [ 136, 292 ] ] } ]
[ { "id": "DS.d1115.s0.e0", "type": "compound", "text": [ "Cu" ], "offsets": [ [ 0, 2 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104815" } ] }, { "id": "DS.d1115.s0.e1", "type": "protein", "text": [ "AST" ], "offsets": [ [ 103, 106 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0AE37" }, { "db_name": "UniProt", "db_id": "P0AE38" }, { "db_name": "UniProt", "db_id": "P80357" }, { "db_name": "UniProt", "db_id": "P80358" }, { "db_name": "UniProt", "db_id": "Q0TH83" }, { "db_name": "UniProt", "db_id": "Q1C8B0" }, { "db_name": "UniProt", "db_id": "Q1RB46" }, { "db_name": "UniProt", "db_id": "Q321N9" }, { "db_name": "UniProt", "db_id": "Q32G89" }, { "db_name": "UniProt", "db_id": "Q3Z294" }, { "db_name": "UniProt", "db_id": "Q5PHB9" }, { "db_name": "UniProt", "db_id": "Q66B20" }, { "db_name": "UniProt", "db_id": "Q7N2G8" }, { "db_name": "UniProt", "db_id": "Q83L52" }, { "db_name": "UniProt", "db_id": "Q8FH00" }, { "db_name": "UniProt", "db_id": "Q8Z6G0" }, { "db_name": "UniProt", "db_id": "Q8ZPV1" }, { "db_name": "UniProt", "db_id": "Q9NRA2" }, { "db_name": "UniProt", "db_id": "Q9ZC67" } ] }, { "id": "DS.d1115.s1.e0", "type": "compound", "text": [ "Cu" ], "offsets": [ [ 153, 155 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104815" } ] }, { "id": "DS.d1115.s1.e1", "type": "protein", "text": [ "superoxide dismutase" ], "offsets": [ [ 171, 191 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] }, { "id": "DS.d1115.s1.e2", "type": "protein", "text": [ "SOD" ], "offsets": [ [ 193, 196 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12933" }, { "db_name": "UniProt", "db_id": "O22668" }, { "db_name": "UniProt", "db_id": "O75007" }, { "db_name": "UniProt", "db_id": "P24705" }, { "db_name": "UniProt", "db_id": "P51547" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q01137" }, { "db_name": "UniProt", "db_id": "Q27666" }, { "db_name": "UniProt", "db_id": "Q9SM64" } ] }, { "id": "DS.d1115.s1.e3", "type": "compound", "text": [ "malondialdehyde" ], "offsets": [ [ 210, 225 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10964" } ] } ]
[]
[]
[ { "id": "DS.d1115.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1115.s0.e0", "arg2_id": "DS.d1115.s0.e1", "normalized": [] } ]
DS.d1116
18785000
[ { "id": "DS.d1116.s0", "type": "", "text": [ "We previously reported that inhibition of Rho-kinase (ROCK) by hydroxyl fasudil improves cognitive deficit and neuronal damage in rats with chronic cerebral ischemia (Huang et al., Cell Mol Neurobiol 28:757-768, 2008)." ], "offsets": [ [ 0, 218 ] ] }, { "id": "DS.d1116.s1", "type": "", "text": [ "Finally, in the presence of OGD and fasudil mesylate, superoxide dismutase (SOD) activity was increased by 50% for cortex and by 58% for hippocampus, compared to OGD only group." ], "offsets": [ [ 219, 396 ] ] } ]
[ { "id": "DS.d1116.s0.e0", "type": "protein", "text": [ "Rho" ], "offsets": [ [ 42, 45 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O51891" }, { "db_name": "UniProt", "db_id": "O67031" }, { "db_name": "UniProt", "db_id": "O83281" }, { "db_name": "UniProt", "db_id": "P03304" }, { "db_name": "UniProt", "db_id": "P0A295" }, { "db_name": "UniProt", "db_id": "P0A296" }, { "db_name": "UniProt", "db_id": "P0AG30" }, { "db_name": "UniProt", "db_id": "P0AG31" }, { "db_name": "UniProt", "db_id": "P0AG32" }, { "db_name": "UniProt", "db_id": "P0AG33" }, { "db_name": "UniProt", "db_id": "P15409" }, { "db_name": "UniProt", "db_id": "P17593" }, { "db_name": "UniProt", "db_id": "P17594" }, { "db_name": "UniProt", "db_id": "P20350" }, { "db_name": "UniProt", "db_id": "P29403" }, { "db_name": "UniProt", "db_id": "P33561" }, { "db_name": "UniProt", "db_id": "P35359" }, { "db_name": "UniProt", "db_id": "P38527" }, { "db_name": "UniProt", "db_id": "P44619" }, { "db_name": "UniProt", "db_id": "P45835" }, { "db_name": "UniProt", "db_id": "P51489" }, { "db_name": "UniProt", "db_id": "P52152" }, { "db_name": "UniProt", "db_id": "P52153" }, { "db_name": "UniProt", "db_id": "P52154" }, { "db_name": "UniProt", "db_id": "P52155" }, { "db_name": "UniProt", "db_id": "P52156" }, { "db_name": "UniProt", "db_id": "P52157" }, { "db_name": "UniProt", "db_id": "P52158" }, { "db_name": "UniProt", "db_id": "P56466" }, { "db_name": "UniProt", "db_id": "P57652" }, { "db_name": "UniProt", "db_id": "P66028" }, { "db_name": "UniProt", "db_id": "P66029" }, { "db_name": "UniProt", "db_id": "Q03222" }, { "db_name": "UniProt", "db_id": "Q06447" }, { "db_name": "UniProt", "db_id": "Q89A22" }, { "db_name": "UniProt", "db_id": "Q9ZD24" }, { "db_name": "UniProt", "db_id": "Q9ZLS9" } ] }, { "id": "DS.d1116.s0.e1", "type": "compound", "text": [ "fasudil" ], "offsets": [ [ 72, 79 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3547" } ] }, { "id": "DS.d1116.s1.e0", "type": "compound", "text": [ "fasudil" ], "offsets": [ [ 255, 262 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3547" } ] }, { "id": "DS.d1116.s1.e1", "type": "protein", "text": [ "superoxide dismutase" ], "offsets": [ [ 273, 293 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] }, { "id": "DS.d1116.s1.e2", "type": "protein", "text": [ "SOD" ], "offsets": [ [ 295, 298 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12933" }, { "db_name": "UniProt", "db_id": "O22668" }, { "db_name": "UniProt", "db_id": "O75007" }, { "db_name": "UniProt", "db_id": "P24705" }, { "db_name": "UniProt", "db_id": "P51547" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q01137" }, { "db_name": "UniProt", "db_id": "Q27666" }, { "db_name": "UniProt", "db_id": "Q9SM64" } ] } ]
[]
[]
[ { "id": "DS.d1116.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1116.s0.e1", "arg2_id": "DS.d1116.s0.e0", "normalized": [] }, { "id": "DS.d1116.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1116.s1.e0", "arg2_id": "DS.d1116.s1.e2", "normalized": [] }, { "id": "DS.d1116.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1116.s1.e0", "arg2_id": "DS.d1116.s1.e1", "normalized": [] } ]
DS.d1117
18785066
[ { "id": "DS.d1117.s0", "type": "", "text": [ "Na+/H+ exchanger isoform 3 (NHE-3) is responsible for net uptake of NaCl and water from the gastrointestinal (GI) tract." ], "offsets": [ [ 0, 120 ] ] } ]
[ { "id": "DS.d1117.s0.e0", "type": "protein", "text": [ "NHE-3" ], "offsets": [ [ 28, 33 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P26432" }, { "db_name": "UniProt", "db_id": "P26433" }, { "db_name": "UniProt", "db_id": "P48764" }, { "db_name": "UniProt", "db_id": "Q28362" }, { "db_name": "UniProt", "db_id": "Q84WG1" } ] }, { "id": "DS.d1117.s0.e1", "type": "compound", "text": [ "NaCl" ], "offsets": [ [ 68, 72 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5234" } ] } ]
[]
[]
[ { "id": "DS.d1117.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1117.s0.e1", "arg2_id": "DS.d1117.s0.e0", "normalized": [] } ]
DS.d1118
18785206
[ { "id": "DS.d1118.s0", "type": "", "text": [ "PDE4B is also important in the regulation of cAMP signaling, a second messenger implicated in learning, memory, and mood." ], "offsets": [ [ 0, 121 ] ] } ]
[ { "id": "DS.d1118.s0.e0", "type": "protein", "text": [ "PDE4B" ], "offsets": [ [ 0, 5 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q07343" } ] }, { "id": "DS.d1118.s0.e1", "type": "compound", "text": [ "cAMP" ], "offsets": [ [ 45, 49 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6076" } ] } ]
[]
[]
[ { "id": "DS.d1118.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1118.s0.e1", "arg2_id": "DS.d1118.s0.e0", "normalized": [] } ]
DS.d1119
18785212
[ { "id": "DS.d1119.s0", "type": "", "text": [ "Elevated amounts of PGK1, one of the ATP-generating reactions of glycolysis, in wood frog brain during freezing would enhance the glycolytic capacity of the organ and support the maintenance of cellular energetics under the ischemic conditions of the frozen state." ], "offsets": [ [ 0, 264 ] ] } ]
[ { "id": "DS.d1119.s0.e0", "type": "protein", "text": [ "PGK1" ], "offsets": [ [ 20, 24 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00558" }, { "db_name": "UniProt", "db_id": "P00559" }, { "db_name": "UniProt", "db_id": "P00560" }, { "db_name": "UniProt", "db_id": "P29405" }, { "db_name": "UniProt", "db_id": "P29407" }, { "db_name": "UniProt", "db_id": "P29408" }, { "db_name": "UniProt", "db_id": "P41757" }, { "db_name": "UniProt", "db_id": "P46273" }, { "db_name": "UniProt", "db_id": "P50310" }, { "db_name": "UniProt", "db_id": "Q3T0P6" }, { "db_name": "UniProt", "db_id": "Q5NVB5" }, { "db_name": "UniProt", "db_id": "Q60HD8" }, { "db_name": "UniProt", "db_id": "Q6BLA0" }, { "db_name": "UniProt", "db_id": "Q6FKY1" }, { "db_name": "UniProt", "db_id": "Q757Q0" }, { "db_name": "UniProt", "db_id": "Q7SIB7" }, { "db_name": "UniProt", "db_id": "Q7ZA46" } ] }, { "id": "DS.d1119.s0.e1", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 37, 40 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] } ]
[]
[]
[ { "id": "DS.d1119.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1119.s0.e1", "arg2_id": "DS.d1119.s0.e0", "normalized": [] } ]
DS.d1120
18785685
[ { "id": "DS.d1120.s0", "type": "", "text": [ "SNs and SMs were exposed to macrophages with and without addition of endotoxin lipopolysaccharide (LPS), a positive inducer of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and nitric oxide (NO)." ], "offsets": [ [ 0, 212 ] ] } ]
[ { "id": "DS.d1120.s0.e0", "type": "compound", "text": [ "endotoxin lipopolysaccharide" ], "offsets": [ [ 69, 97 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "53481793" } ] }, { "id": "DS.d1120.s0.e1", "type": "protein", "text": [ "tumor necrosis factor" ], "offsets": [ [ 127, 148 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8JFG3" } ] }, { "id": "DS.d1120.s0.e2", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 156, 165 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d1120.s0.e3", "type": "protein", "text": [ "interleukin 6" ], "offsets": [ [ 168, 181 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P41693" } ] }, { "id": "DS.d1120.s0.e4", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 183, 187 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d1120.s0.e5", "type": "compound", "text": [ "nitric oxide" ], "offsets": [ [ 194, 206 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] } ]
[]
[]
[ { "id": "DS.d1120.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1120.s0.e0", "arg2_id": "DS.d1120.s0.e4", "normalized": [] }, { "id": "DS.d1120.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d1120.s0.e0", "arg2_id": "DS.d1120.s0.e2", "normalized": [] }, { "id": "DS.d1120.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d1120.s0.e0", "arg2_id": "DS.d1120.s0.e3", "normalized": [] }, { "id": "DS.d1120.s0.i7", "type": "compound-protein-interaction", "arg1_id": "DS.d1120.s0.e0", "arg2_id": "DS.d1120.s0.e1", "normalized": [] } ]
DS.d1121
18785878
[ { "id": "DS.d1121.s0", "type": "", "text": [ "We therefore hypothesized that a diffusible product of the GPI-PLC enzyme reaction (possibly DAG (diacylglycerol)) mediated the biological effects of the protein." ], "offsets": [ [ 0, 162 ] ] } ]
[ { "id": "DS.d1121.s0.e0", "type": "protein", "text": [ "GPI-PLC" ], "offsets": [ [ 59, 66 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15886" }, { "db_name": "UniProt", "db_id": "P09194" } ] }, { "id": "DS.d1121.s0.e1", "type": "compound", "text": [ "diacylglycerol" ], "offsets": [ [ 98, 112 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6026790" } ] } ]
[]
[]
[ { "id": "DS.d1121.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1121.s0.e1", "arg2_id": "DS.d1121.s0.e0", "normalized": [] } ]
DS.d1122
18786000
[ { "id": "DS.d1122.s0", "type": "", "text": [ "Silencing of chalcone synthase, the key entry-point enzyme for flavonoid biosynthesis led to flavonoid-deficient roots." ], "offsets": [ [ 0, 119 ] ] } ]
[ { "id": "DS.d1122.s0.e0", "type": "protein", "text": [ "chalcone synthase" ], "offsets": [ [ 13, 30 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O04111" }, { "db_name": "UniProt", "db_id": "O04220" }, { "db_name": "UniProt", "db_id": "O22586" }, { "db_name": "UniProt", "db_id": "O22652" }, { "db_name": "UniProt", "db_id": "O65872" }, { "db_name": "UniProt", "db_id": "O82144" }, { "db_name": "UniProt", "db_id": "P06515" }, { "db_name": "UniProt", "db_id": "P13114" }, { "db_name": "UniProt", "db_id": "P16107" }, { "db_name": "UniProt", "db_id": "P17818" }, { "db_name": "UniProt", "db_id": "P23569" }, { "db_name": "UniProt", "db_id": "P30078" }, { "db_name": "UniProt", "db_id": "P30079" }, { "db_name": "UniProt", "db_id": "P48385" }, { "db_name": "UniProt", "db_id": "P48389" }, { "db_name": "UniProt", "db_id": "P48405" }, { "db_name": "UniProt", "db_id": "P51075" }, { "db_name": "UniProt", "db_id": "P51080" }, { "db_name": "UniProt", "db_id": "P51089" }, { "db_name": "UniProt", "db_id": "P51090" }, { "db_name": "UniProt", "db_id": "Q9FUB7" }, { "db_name": "UniProt", "db_id": "Q9LKP7" }, { "db_name": "UniProt", "db_id": "Q9MBB1" }, { "db_name": "UniProt", "db_id": "Q9SEP2" }, { "db_name": "UniProt", "db_id": "Q9SEP4" }, { "db_name": "UniProt", "db_id": "Q9ZRR8" }, { "db_name": "UniProt", "db_id": "Q9ZRS4" }, { "db_name": "UniProt", "db_id": "Q9ZU06" } ] }, { "id": "DS.d1122.s0.e1", "type": "compound", "text": [ "flavonoid" ], "offsets": [ [ 63, 72 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10251" } ] } ]
[]
[]
[ { "id": "DS.d1122.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1122.s0.e1", "arg2_id": "DS.d1122.s0.e0", "normalized": [] } ]
DS.d1123
18786181
[ { "id": "DS.d1123.s0", "type": "", "text": [ "Nitrilase enzymes have been characterised in plants, bacteria and fungi and are thought to be important in detoxification of nitriles, utilisation of nitrogen and synthesis of plant hormones." ], "offsets": [ [ 0, 191 ] ] }, { "id": "DS.d1123.s1", "type": "", "text": [ "In plants cyanide is converted to beta-cyano-L-alanine, which is subsequently detoxified to aspartic acid and ammonia by NIT4." ], "offsets": [ [ 192, 318 ] ] } ]
[ { "id": "DS.d1123.s0.e0", "type": "protein", "text": [ "Nitrilase" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13448" }, { "db_name": "UniProt", "db_id": "P13449" }, { "db_name": "UniProt", "db_id": "P27763" }, { "db_name": "UniProt", "db_id": "P27764" }, { "db_name": "UniProt", "db_id": "P33036" }, { "db_name": "UniProt", "db_id": "P82605" }, { "db_name": "UniProt", "db_id": "P97051" }, { "db_name": "UniProt", "db_id": "P97052" }, { "db_name": "UniProt", "db_id": "Q53117" }, { "db_name": "UniProt", "db_id": "Q53118" } ] }, { "id": "DS.d1123.s0.e1", "type": "compound", "text": [ "nitrogen" ], "offsets": [ [ 150, 158 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "947" }, { "db_name": "PubChem", "db_id": "123329" } ] }, { "id": "DS.d1123.s1.e0", "type": "compound", "text": [ "aspartic acid" ], "offsets": [ [ 284, 297 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "424" }, { "db_name": "PubChem", "db_id": "5960" }, { "db_name": "PubChem", "db_id": "83887" } ] }, { "id": "DS.d1123.s1.e1", "type": "compound", "text": [ "ammonia" ], "offsets": [ [ 302, 309 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "222" } ] }, { "id": "DS.d1123.s1.e2", "type": "protein", "text": [ "NIT4" ], "offsets": [ [ 313, 317 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P46011" }, { "db_name": "UniProt", "db_id": "Q42965" } ] } ]
[]
[]
[ { "id": "DS.d1123.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1123.s0.e1", "arg2_id": "DS.d1123.s0.e0", "normalized": [] }, { "id": "DS.d1123.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1123.s1.e1", "arg2_id": "DS.d1123.s1.e2", "normalized": [] }, { "id": "DS.d1123.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1123.s1.e0", "arg2_id": "DS.d1123.s1.e2", "normalized": [] } ]
DS.d1124
18786182
[ { "id": "DS.d1124.s0", "type": "", "text": [ "The mitochondrial membrane potential (Delta psi (mit)) was also tested with rhodamine 123 30 min after SI challenge, and was shown to have collapsed in the incompatible pollen tubes after exposure to S-RNase." ], "offsets": [ [ 0, 208 ] ] } ]
[ { "id": "DS.d1124.s0.e0", "type": "compound", "text": [ "rhodamine 123" ], "offsets": [ [ 76, 89 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65218" } ] }, { "id": "DS.d1124.s0.e1", "type": "protein", "text": [ "S-RNase" ], "offsets": [ [ 200, 207 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00669" } ] } ]
[]
[]
[ { "id": "DS.d1124.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1124.s0.e0", "arg2_id": "DS.d1124.s0.e1", "normalized": [] } ]
DS.d1125
18786279
[ { "id": "DS.d1125.s0", "type": "", "text": [ "In conclusion, female rats undernourished in utero had normophagic obesity as adults but had an absence of serotonin-induced hypophagia and low hypothalamic levels of the 5-HT 2C receptor." ], "offsets": [ [ 0, 188 ] ] }, { "id": "DS.d1125.s1", "type": "", "text": [ "Compensatory adaptations for the functional serotonergic impairment were evidenced, such as an enhanced release of serotonin in response to a meal allied to up-regulated hypothalamic 5-HT1B and transporter expression." ], "offsets": [ [ 189, 406 ] ] } ]
[ { "id": "DS.d1125.s0.e0", "type": "compound", "text": [ "serotonin" ], "offsets": [ [ 107, 116 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5202" } ] }, { "id": "DS.d1125.s0.e1", "type": "protein", "text": [ "5-HT 2C" ], "offsets": [ [ 171, 178 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08909" }, { "db_name": "UniProt", "db_id": "P28335" }, { "db_name": "UniProt", "db_id": "P34968" }, { "db_name": "UniProt", "db_id": "Q5IS66" }, { "db_name": "UniProt", "db_id": "Q60F97" } ] }, { "id": "DS.d1125.s1.e0", "type": "compound", "text": [ "serotonin" ], "offsets": [ [ 304, 313 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5202" } ] }, { "id": "DS.d1125.s1.e1", "type": "protein", "text": [ "5-HT1B" ], "offsets": [ [ 372, 378 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08892" }, { "db_name": "UniProt", "db_id": "P28222" }, { "db_name": "UniProt", "db_id": "P28286" }, { "db_name": "UniProt", "db_id": "P28334" }, { "db_name": "UniProt", "db_id": "P28564" }, { "db_name": "UniProt", "db_id": "P35404" }, { "db_name": "UniProt", "db_id": "P46636" }, { "db_name": "UniProt", "db_id": "P49144" }, { "db_name": "UniProt", "db_id": "P56496" }, { "db_name": "UniProt", "db_id": "P60020" }, { "db_name": "UniProt", "db_id": "P79250" }, { "db_name": "UniProt", "db_id": "P79399" }, { "db_name": "UniProt", "db_id": "Q588Y6" }, { "db_name": "UniProt", "db_id": "Q6XXX8" }, { "db_name": "UniProt", "db_id": "Q9N2B7" } ] } ]
[]
[]
[ { "id": "DS.d1125.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1125.s1.e0", "arg2_id": "DS.d1125.s1.e1", "normalized": [] } ]
DS.d1126
18786604
[ { "id": "DS.d1126.s0", "type": "", "text": [ "The proliferation of the parental cell line was most efficiently stimulated by 5alpha-dihydrotestosterone (DHT), but the LNCaP(17beta-HSD3) cells were equally stimulated by Adione, indicating that 17beta-HSD3 efficiently converts Adione to T in this model." ], "offsets": [ [ 0, 256 ] ] } ]
[ { "id": "DS.d1126.s0.e0", "type": "compound", "text": [ "5alpha-dihydrotestosterone" ], "offsets": [ [ 79, 105 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10635" } ] }, { "id": "DS.d1126.s0.e1", "type": "compound", "text": [ "DHT" ], "offsets": [ [ 107, 110 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10635" } ] }, { "id": "DS.d1126.s0.e2", "type": "protein", "text": [ "17beta-HSD3" ], "offsets": [ [ 127, 138 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54939" }, { "db_name": "UniProt", "db_id": "P37058" }, { "db_name": "UniProt", "db_id": "P70385" } ] }, { "id": "DS.d1126.s0.e3", "type": "protein", "text": [ "17beta-HSD3" ], "offsets": [ [ 197, 208 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54939" }, { "db_name": "UniProt", "db_id": "P37058" }, { "db_name": "UniProt", "db_id": "P70385" } ] } ]
[]
[]
[]
DS.d1127
18786605
[ { "id": "DS.d1127.s0", "type": "", "text": [ "They potentiate glucose-induced insulin secretion and may be responsible for up to 70% of postprandial insulin secretion." ], "offsets": [ [ 0, 121 ] ] }, { "id": "DS.d1127.s1", "type": "", "text": [ "However, in supraphysiological doses, GLP-1 administration may completely normalize beta as well as alpha cell sensitivity to glucose." ], "offsets": [ [ 122, 256 ] ] } ]
[ { "id": "DS.d1127.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 16, 23 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1127.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 32, 39 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1127.s0.e2", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 103, 110 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1127.s1.e0", "type": "protein", "text": [ "GLP-1" ], "offsets": [ [ 160, 165 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12956" }, { "db_name": "UniProt", "db_id": "P01272" }, { "db_name": "UniProt", "db_id": "P01273" }, { "db_name": "UniProt", "db_id": "P01274" }, { "db_name": "UniProt", "db_id": "P01275" }, { "db_name": "UniProt", "db_id": "P05110" }, { "db_name": "UniProt", "db_id": "P06883" }, { "db_name": "UniProt", "db_id": "P22890" }, { "db_name": "UniProt", "db_id": "P29794" }, { "db_name": "UniProt", "db_id": "P55095" }, { "db_name": "UniProt", "db_id": "P68259" }, { "db_name": "UniProt", "db_id": "Q06605" }, { "db_name": "UniProt", "db_id": "Q8MJ25" } ] }, { "id": "DS.d1127.s1.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 248, 255 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] } ]
[]
[]
[ { "id": "DS.d1127.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1127.s0.e0", "arg2_id": "DS.d1127.s0.e1", "normalized": [] }, { "id": "DS.d1127.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1127.s1.e1", "arg2_id": "DS.d1127.s1.e0", "normalized": [] } ]
DS.d1128
18786649
[ { "id": "DS.d1128.s0", "type": "", "text": [ "The induction of signal transduction by serum and growth factors significantly increases the level of S6K ubiquitination, while the treatment of cells with UV and staurosporine has the opposite effect." ], "offsets": [ [ 0, 201 ] ] } ]
[ { "id": "DS.d1128.s0.e0", "type": "protein", "text": [ "S6K" ], "offsets": [ [ 102, 105 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P23443" }, { "db_name": "UniProt", "db_id": "P67998" }, { "db_name": "UniProt", "db_id": "P67999" }, { "db_name": "UniProt", "db_id": "Q6TJY3" }, { "db_name": "UniProt", "db_id": "Q8BSK8" } ] }, { "id": "DS.d1128.s0.e1", "type": "compound", "text": [ "staurosporine" ], "offsets": [ [ 163, 176 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5279" }, { "db_name": "PubChem", "db_id": "44259" }, { "db_name": "PubChem", "db_id": "451705" }, { "db_name": "PubChem", "db_id": "5311103" }, { "db_name": "PubChem", "db_id": "5459111" }, { "db_name": "PubChem", "db_id": "6419748" }, { "db_name": "PubChem", "db_id": "6711321" }, { "db_name": "PubChem", "db_id": "9956178" }, { "db_name": "PubChem", "db_id": "44299148" } ] } ]
[]
[]
[ { "id": "DS.d1128.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1128.s0.e1", "arg2_id": "DS.d1128.s0.e0", "normalized": [] } ]
DS.d1129
18786760
[ { "id": "DS.d1129.s0", "type": "", "text": [ "Interaction of malachite green with bovine serum albumin : determination of the binding mechanism and binding site by spectroscopic methods." ], "offsets": [ [ 0, 140 ] ] }, { "id": "DS.d1129.s1", "type": "", "text": [ "The interaction between malachite green (MG) and bovine serum albumin (BSA) under simulative physiological conditions was investigated by the methods of fluorescence spectroscopy, UV-vis absorption and circular dichroism (CD) spectroscopy." ], "offsets": [ [ 141, 380 ] ] }, { "id": "DS.d1129.s2", "type": "", "text": [ "The binding distance (r) between MG and the tryptophan residue of BSA was obtained to be 4.79 nm according to Förster theory of non-radioactive energy transfer." ], "offsets": [ [ 381, 541 ] ] } ]
[ { "id": "DS.d1129.s0.e0", "type": "compound", "text": [ "malachite green" ], "offsets": [ [ 15, 30 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11295" } ] }, { "id": "DS.d1129.s0.e1", "type": "protein", "text": [ "serum albumin" ], "offsets": [ [ 43, 56 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21847" }, { "db_name": "UniProt", "db_id": "P83517" } ] }, { "id": "DS.d1129.s1.e0", "type": "compound", "text": [ "malachite green" ], "offsets": [ [ 165, 180 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11295" } ] }, { "id": "DS.d1129.s1.e1", "type": "protein", "text": [ "serum albumin" ], "offsets": [ [ 197, 210 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21847" }, { "db_name": "UniProt", "db_id": "P83517" } ] }, { "id": "DS.d1129.s1.e2", "type": "protein", "text": [ "BSA" ], "offsets": [ [ 212, 215 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02769" } ] }, { "id": "DS.d1129.s2.e0", "type": "compound", "text": [ "tryptophan" ], "offsets": [ [ 425, 435 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1148" }, { "db_name": "PubChem", "db_id": "6305" }, { "db_name": "PubChem", "db_id": "9060" }, { "db_name": "PubChem", "db_id": "5460840" } ] }, { "id": "DS.d1129.s2.e1", "type": "protein", "text": [ "BSA" ], "offsets": [ [ 447, 450 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02769" } ] } ]
[]
[]
[ { "id": "DS.d1129.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1129.s0.e0", "arg2_id": "DS.d1129.s0.e1", "normalized": [] }, { "id": "DS.d1129.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1129.s1.e0", "arg2_id": "DS.d1129.s1.e1", "normalized": [] }, { "id": "DS.d1129.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1129.s1.e0", "arg2_id": "DS.d1129.s1.e2", "normalized": [] }, { "id": "DS.d1129.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1129.s2.e0", "arg2_id": "DS.d1129.s2.e1", "normalized": [] } ]
DS.d1130
18786974
[ { "id": "DS.d1130.s0", "type": "", "text": [ "Unlike creatinine, Cystatin C (CysC) is believed to be independent of body composition in both adults and children." ], "offsets": [ [ 0, 115 ] ] } ]
[ { "id": "DS.d1130.s0.e0", "type": "compound", "text": [ "creatinine" ], "offsets": [ [ 7, 17 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "588" } ] }, { "id": "DS.d1130.s0.e1", "type": "protein", "text": [ "Cystatin" ], "offsets": [ [ 19, 27 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08935" }, { "db_name": "UniProt", "db_id": "P25973" }, { "db_name": "UniProt", "db_id": "P81061" }, { "db_name": "UniProt", "db_id": "P81714" }, { "db_name": "UniProt", "db_id": "Q06445" } ] }, { "id": "DS.d1130.s0.e2", "type": "protein", "text": [ "CysC" ], "offsets": [ [ 31, 35 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O29953" }, { "db_name": "UniProt", "db_id": "O34577" }, { "db_name": "UniProt", "db_id": "P0A6J1" }, { "db_name": "UniProt", "db_id": "P0A6J2" }, { "db_name": "UniProt", "db_id": "P56858" }, { "db_name": "UniProt", "db_id": "P56861" }, { "db_name": "UniProt", "db_id": "P57497" }, { "db_name": "UniProt", "db_id": "P57702" }, { "db_name": "UniProt", "db_id": "P63889" }, { "db_name": "UniProt", "db_id": "P63890" }, { "db_name": "UniProt", "db_id": "P72940" }, { "db_name": "UniProt", "db_id": "Q5HL02" }, { "db_name": "UniProt", "db_id": "Q7MPF0" }, { "db_name": "UniProt", "db_id": "Q7UMW2" }, { "db_name": "UniProt", "db_id": "Q7UQW3" }, { "db_name": "UniProt", "db_id": "Q87SX6" }, { "db_name": "UniProt", "db_id": "Q88X60" }, { "db_name": "UniProt", "db_id": "Q8CR04" }, { "db_name": "UniProt", "db_id": "Q8DE75" }, { "db_name": "UniProt", "db_id": "Q8DJ87" }, { "db_name": "UniProt", "db_id": "Q8EB13" }, { "db_name": "UniProt", "db_id": "Q8FEJ2" }, { "db_name": "UniProt", "db_id": "Q8K9D4" }, { "db_name": "UniProt", "db_id": "Q8ZBP3" }, { "db_name": "UniProt", "db_id": "Q97MT8" }, { "db_name": "UniProt", "db_id": "Q9KP21" }, { "db_name": "UniProt", "db_id": "Q9YCR6" } ] } ]
[]
[]
[]
DS.d1131
18787021
[ { "id": "DS.d1131.s0", "type": "", "text": [ "Levels of endothelial nitric oxide synthase and inducible nitric oxide synthase did not differ among the groups, nor did total nitrite plus nitrate levels." ], "offsets": [ [ 0, 155 ] ] } ]
[ { "id": "DS.d1131.s0.e0", "type": "protein", "text": [ "nitric oxide synthase" ], "offsets": [ [ 22, 43 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d1131.s0.e1", "type": "protein", "text": [ "nitric oxide synthase" ], "offsets": [ [ 58, 79 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d1131.s0.e2", "type": "compound", "text": [ "nitrate" ], "offsets": [ [ 140, 147 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "943" } ] } ]
[]
[]
[]
DS.d1132
18787024
[ { "id": "DS.d1132.s0", "type": "", "text": [ "Glucose controls cytosolic Ca2+ and insulin secretion in mouse islets lacking adenosine triphosphate-sensitive K+ channels owing to a knockout of the pore-forming subunit Kir6.2." ], "offsets": [ [ 0, 178 ] ] } ]
[ { "id": "DS.d1132.s0.e0", "type": "compound", "text": [ "Glucose" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1132.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 36, 43 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1132.s0.e2", "type": "compound", "text": [ "adenosine triphosphate" ], "offsets": [ [ 78, 100 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] } ]
[]
[]
[ { "id": "DS.d1132.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1132.s0.e0", "arg2_id": "DS.d1132.s0.e1", "normalized": [] }, { "id": "DS.d1132.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1132.s0.e2", "arg2_id": "DS.d1132.s0.e1", "normalized": [] } ]
DS.d1133
18787032
[ { "id": "DS.d1133.s0", "type": "", "text": [ "Thereafter we determined that hCG effect could be partially blocked by pharmacologic inhibition of MAPK pathway with 50 microM PD98059 but not by the inhibition of the phosphatidylinositol 3-kinase pathway with 0.1 microm wortmannin." ], "offsets": [ [ 0, 233 ] ] } ]
[ { "id": "DS.d1133.s0.e0", "type": "protein", "text": [ "MAPK" ], "offsets": [ [ 99, 103 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42781" }, { "db_name": "UniProt", "db_id": "P27638" }, { "db_name": "UniProt", "db_id": "Q00859" } ] }, { "id": "DS.d1133.s0.e1", "type": "compound", "text": [ "PD98059" ], "offsets": [ [ 127, 134 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4713" } ] }, { "id": "DS.d1133.s0.e2", "type": "compound", "text": [ "wortmannin" ], "offsets": [ [ 222, 232 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "312145" } ] } ]
[]
[]
[ { "id": "DS.d1133.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1133.s0.e1", "arg2_id": "DS.d1133.s0.e0", "normalized": [] } ]
DS.d1134
18787174
[ { "id": "DS.d1134.s0", "type": "", "text": [ "Lung injury was assessed by measuring vascular permeability (via Evans blue dye), edema, neutrophil infiltration (via myeloperoxidase (MPO), and expression of proinflammatory cytokines." ], "offsets": [ [ 0, 185 ] ] } ]
[ { "id": "DS.d1134.s0.e0", "type": "compound", "text": [ "Evans blue dye" ], "offsets": [ [ 65, 79 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9566058" } ] }, { "id": "DS.d1134.s0.e1", "type": "protein", "text": [ "MPO" ], "offsets": [ [ 135, 138 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05164" }, { "db_name": "UniProt", "db_id": "P11247" } ] } ]
[]
[]
[]
DS.d1135
18787236
[ { "id": "DS.d1135.s0", "type": "", "text": [ "Cholesterol efflux from ((3)H) cholesterol-oleate-acetyl-LDL-loaded monocyte-derived macrophages to standard apolipoprotein A-I (apoA-I), HDL(2), and serum was measured." ], "offsets": [ [ 0, 169 ] ] }, { "id": "DS.d1135.s1", "type": "", "text": [ "Cholesterol efflux to apoA-I, HDL(2), and serum from macrophage foam cells derived from low- and high-HDL subjects was similar." ], "offsets": [ [ 170, 297 ] ] }, { "id": "DS.d1135.s2", "type": "", "text": [ "Cholesterol efflux from THP-1 macrophages to serum from study subjects correlated with serum apoB (P = 0.033), apoA-I (P = 0.004), apoA-II 0.0001), and the percentage of apoA-I present in the form of prebeta-HDL (P = 0.0001)." ], "offsets": [ [ 298, 523 ] ] } ]
[ { "id": "DS.d1135.s0.e0", "type": "compound", "text": [ "Cholesterol" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d1135.s0.e1", "type": "compound", "text": [ "cholesterol-oleate" ], "offsets": [ [ 31, 49 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5283632" } ] }, { "id": "DS.d1135.s0.e2", "type": "protein", "text": [ "apolipoprotein A-I" ], "offsets": [ [ 109, 127 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P18647" } ] }, { "id": "DS.d1135.s0.e3", "type": "protein", "text": [ "apoA-I" ], "offsets": [ [ 129, 135 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18759" }, { "db_name": "UniProt", "db_id": "O42175" }, { "db_name": "UniProt", "db_id": "O42296" }, { "db_name": "UniProt", "db_id": "O42363" }, { "db_name": "UniProt", "db_id": "P02647" }, { "db_name": "UniProt", "db_id": "P02648" }, { "db_name": "UniProt", "db_id": "P04639" }, { "db_name": "UniProt", "db_id": "P08250" }, { "db_name": "UniProt", "db_id": "P09809" }, { "db_name": "UniProt", "db_id": "P15497" }, { "db_name": "UniProt", "db_id": "P18647" }, { "db_name": "UniProt", "db_id": "P18648" }, { "db_name": "UniProt", "db_id": "P27007" }, { "db_name": "UniProt", "db_id": "P32918" }, { "db_name": "UniProt", "db_id": "P68292" }, { "db_name": "UniProt", "db_id": "P68293" }, { "db_name": "UniProt", "db_id": "Q00623" }, { "db_name": "UniProt", "db_id": "Q91488" }, { "db_name": "UniProt", "db_id": "Q9Z2L4" } ] }, { "id": "DS.d1135.s1.e0", "type": "compound", "text": [ "Cholesterol" ], "offsets": [ [ 170, 181 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d1135.s1.e1", "type": "protein", "text": [ "apoA-I" ], "offsets": [ [ 192, 198 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18759" }, { "db_name": "UniProt", "db_id": "O42175" }, { "db_name": "UniProt", "db_id": "O42296" }, { "db_name": "UniProt", "db_id": "O42363" }, { "db_name": "UniProt", "db_id": "P02647" }, { "db_name": "UniProt", "db_id": "P02648" }, { "db_name": "UniProt", "db_id": "P04639" }, { "db_name": "UniProt", "db_id": "P08250" }, { "db_name": "UniProt", "db_id": "P09809" }, { "db_name": "UniProt", "db_id": "P15497" }, { "db_name": "UniProt", "db_id": "P18647" }, { "db_name": "UniProt", "db_id": "P18648" }, { "db_name": "UniProt", "db_id": "P27007" }, { "db_name": "UniProt", "db_id": "P32918" }, { "db_name": "UniProt", "db_id": "P68292" }, { "db_name": "UniProt", "db_id": "P68293" }, { "db_name": "UniProt", "db_id": "Q00623" }, { "db_name": "UniProt", "db_id": "Q91488" }, { "db_name": "UniProt", "db_id": "Q9Z2L4" } ] }, { "id": "DS.d1135.s2.e0", "type": "compound", "text": [ "Cholesterol" ], "offsets": [ [ 298, 309 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d1135.s2.e1", "type": "protein", "text": [ "apoA-I" ], "offsets": [ [ 409, 415 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18759" }, { "db_name": "UniProt", "db_id": "O42175" }, { "db_name": "UniProt", "db_id": "O42296" }, { "db_name": "UniProt", "db_id": "O42363" }, { "db_name": "UniProt", "db_id": "P02647" }, { "db_name": "UniProt", "db_id": "P02648" }, { "db_name": "UniProt", "db_id": "P04639" }, { "db_name": "UniProt", "db_id": "P08250" }, { "db_name": "UniProt", "db_id": "P09809" }, { "db_name": "UniProt", "db_id": "P15497" }, { "db_name": "UniProt", "db_id": "P18647" }, { "db_name": "UniProt", "db_id": "P18648" }, { "db_name": "UniProt", "db_id": "P27007" }, { "db_name": "UniProt", "db_id": "P32918" }, { "db_name": "UniProt", "db_id": "P68292" }, { "db_name": "UniProt", "db_id": "P68293" }, { "db_name": "UniProt", "db_id": "Q00623" }, { "db_name": "UniProt", "db_id": "Q91488" }, { "db_name": "UniProt", "db_id": "Q9Z2L4" } ] }, { "id": "DS.d1135.s2.e2", "type": "protein", "text": [ "apoA-II" ], "offsets": [ [ 429, 436 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02652" }, { "db_name": "UniProt", "db_id": "P02653" }, { "db_name": "UniProt", "db_id": "P04638" }, { "db_name": "UniProt", "db_id": "P09813" }, { "db_name": "UniProt", "db_id": "P18656" }, { "db_name": "UniProt", "db_id": "P81644" }, { "db_name": "UniProt", "db_id": "P83704" }, { "db_name": "UniProt", "db_id": "Q8MIQ5" } ] }, { "id": "DS.d1135.s2.e3", "type": "protein", "text": [ "apoA-I" ], "offsets": [ [ 429, 435 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18759" }, { "db_name": "UniProt", "db_id": "O42175" }, { "db_name": "UniProt", "db_id": "O42296" }, { "db_name": "UniProt", "db_id": "O42363" }, { "db_name": "UniProt", "db_id": "P02647" }, { "db_name": "UniProt", "db_id": "P02648" }, { "db_name": "UniProt", "db_id": "P04639" }, { "db_name": "UniProt", "db_id": "P08250" }, { "db_name": "UniProt", "db_id": "P09809" }, { "db_name": "UniProt", "db_id": "P15497" }, { "db_name": "UniProt", "db_id": "P18647" }, { "db_name": "UniProt", "db_id": "P18648" }, { "db_name": "UniProt", "db_id": "P27007" }, { "db_name": "UniProt", "db_id": "P32918" }, { "db_name": "UniProt", "db_id": "P68292" }, { "db_name": "UniProt", "db_id": "P68293" }, { "db_name": "UniProt", "db_id": "Q00623" }, { "db_name": "UniProt", "db_id": "Q91488" }, { "db_name": "UniProt", "db_id": "Q9Z2L4" } ] } ]
[]
[]
[ { "id": "DS.d1135.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1135.s0.e1", "arg2_id": "DS.d1135.s0.e3", "normalized": [] }, { "id": "DS.d1135.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1135.s0.e0", "arg2_id": "DS.d1135.s0.e3", "normalized": [] }, { "id": "DS.d1135.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1135.s0.e1", "arg2_id": "DS.d1135.s0.e2", "normalized": [] }, { "id": "DS.d1135.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1135.s0.e0", "arg2_id": "DS.d1135.s0.e2", "normalized": [] }, { "id": "DS.d1135.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1135.s2.e0", "arg2_id": "DS.d1135.s2.e1", "normalized": [] }, { "id": "DS.d1135.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1135.s2.e0", "arg2_id": "DS.d1135.s2.e2", "normalized": [] } ]
DS.d1136
18787748
[ { "id": "DS.d1136.s0", "type": "", "text": [ "In this study, the degradation of Rac- and R-metalaxyl under anaerobic conditions was studied." ], "offsets": [ [ 0, 94 ] ] } ]
[ { "id": "DS.d1136.s0.e0", "type": "protein", "text": [ "Rac" ], "offsets": [ [ 34, 37 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31750" } ] }, { "id": "DS.d1136.s0.e1", "type": "compound", "text": [ "metalaxyl" ], "offsets": [ [ 45, 54 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "42586" }, { "db_name": "PubChem", "db_id": "11150163" } ] } ]
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