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DS.d1137
18787757
[ { "id": "DS.d1137.s0", "type": "", "text": [ "Regulation of muscle protein degradation, not synthesis, by dietary leucine in rats fed a protein-deficient diet." ], "offsets": [ [ 0, 113 ] ] } ]
[ { "id": "DS.d1137.s0.e0", "type": "compound", "text": [ "leucine" ], "offsets": [ [ 68, 75 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "857" }, { "db_name": "PubChem", "db_id": "6106" }, { "db_name": "PubChem", "db_id": "439524" } ] }, { "id": "DS.d1137.s0.e1", "type": "protein", "text": [ "a protein" ], "offsets": [ [ 88, 97 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03161" }, { "db_name": "UniProt", "db_id": "P03610" }, { "db_name": "UniProt", "db_id": "P03631" }, { "db_name": "UniProt", "db_id": "P03632" }, { "db_name": "UniProt", "db_id": "P07394" }, { "db_name": "UniProt", "db_id": "P15966" }, { "db_name": "UniProt", "db_id": "P25243" }, { "db_name": "UniProt", "db_id": "P25244" }, { "db_name": "UniProt", "db_id": "P35823" }, { "db_name": "UniProt", "db_id": "P98005" } ] } ]
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DS.d1138
18787837
[ { "id": "DS.d1138.s0", "type": "", "text": [ "Studies of HeLa cells and serum- and glucocorticoid-regulated kinase 1 (SGK1) knockout mice identified threonine residues in the n-myc downstream-regulated gene 1 protein (NDRG1-Thr (346/356/366)) that are phosphorylated by SGK1 but not by related kinases (Murray et al., Biochem J 385:1-12, 2005)." ], "offsets": [ [ 0, 298 ] ] }, { "id": "DS.d1138.s1", "type": "", "text": [ "Although G (Na) is negligible in hormone-deprived cells, these cells displayed basal SGK1 activity that was sensitive to LY294002, an inhibitor of 3-phosphatidylinositol phosphate kinase (PI3K)." ], "offsets": [ [ 299, 493 ] ] } ]
[ { "id": "DS.d1138.s0.e0", "type": "compound", "text": [ "threonine" ], "offsets": [ [ 103, 112 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6288" } ] }, { "id": "DS.d1138.s0.e1", "type": "protein", "text": [ "n-myc downstream-regulated gene 1 protein" ], "offsets": [ [ 129, 170 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q62433" }, { "db_name": "UniProt", "db_id": "Q92597" } ] }, { "id": "DS.d1138.s0.e2", "type": "protein", "text": [ "NDRG1" ], "offsets": [ [ 172, 177 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q92597" } ] }, { "id": "DS.d1138.s1.e0", "type": "protein", "text": [ "SGK1" ], "offsets": [ [ 384, 388 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00141" }, { "db_name": "UniProt", "db_id": "Q9XT18" } ] }, { "id": "DS.d1138.s1.e1", "type": "compound", "text": [ "LY294002" ], "offsets": [ [ 420, 428 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3973" } ] } ]
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[]
[ { "id": "DS.d1138.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1138.s0.e0", "arg2_id": "DS.d1138.s0.e1", "normalized": [] }, { "id": "DS.d1138.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1138.s0.e0", "arg2_id": "DS.d1138.s0.e2", "normalized": [] }, { "id": "DS.d1138.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1138.s1.e1", "arg2_id": "DS.d1138.s1.e0", "normalized": [] } ]
DS.d1139
18787840
[ { "id": "DS.d1139.s0", "type": "", "text": [ "Epidermal growth factor receptor expression analysis in chemotherapy-naive patients with advanced non-small-cell lung cancer treated with gefitinib or placebo in combination with platinum-based chemotherapy." ], "offsets": [ [ 0, 207 ] ] } ]
[ { "id": "DS.d1139.s0.e0", "type": "protein", "text": [ "Epidermal growth factor receptor" ], "offsets": [ [ 0, 32 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P55245" } ] }, { "id": "DS.d1139.s0.e1", "type": "compound", "text": [ "platinum" ], "offsets": [ [ 179, 187 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23939" } ] } ]
[]
[]
[ { "id": "DS.d1139.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1139.s0.e1", "arg2_id": "DS.d1139.s0.e0", "normalized": [] } ]
DS.d1140
18787967
[ { "id": "DS.d1140.s0", "type": "", "text": [ "The present investigation was carried out to assess the erythrocytic oxidative stress indices such as lipid peroxides level and activities of antioxidant enzymes such as superoxide dismutase and catalase, and some hematological parameters after treatment of subclinically ketotic lactating cows with antioxidants, vitamin E and selenium, incorporated in conventional treatment regimen." ], "offsets": [ [ 0, 385 ] ] } ]
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[]
[]
[]
DS.d1141
18787973
[ { "id": "DS.d1141.s0", "type": "", "text": [ "This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury." ], "offsets": [ [ 0, 277 ] ] } ]
[ { "id": "DS.d1141.s0.e0", "type": "compound", "text": [ "molsidomine" ], "offsets": [ [ 51, 62 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4239" } ] }, { "id": "DS.d1141.s0.e1", "type": "compound", "text": [ "nitric oxide" ], "offsets": [ [ 84, 96 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] }, { "id": "DS.d1141.s0.e2", "type": "protein", "text": [ "HIF-1alpha" ], "offsets": [ [ 144, 154 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35800" }, { "db_name": "UniProt", "db_id": "Q0PGG7" }, { "db_name": "UniProt", "db_id": "Q16665" }, { "db_name": "UniProt", "db_id": "Q309Z6" }, { "db_name": "UniProt", "db_id": "Q61221" }, { "db_name": "UniProt", "db_id": "Q98SW2" }, { "db_name": "UniProt", "db_id": "Q9I8A9" }, { "db_name": "UniProt", "db_id": "Q9XTA5" }, { "db_name": "UniProt", "db_id": "Q9YIB9" } ] } ]
[]
[]
[ { "id": "DS.d1141.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1141.s0.e1", "arg2_id": "DS.d1141.s0.e2", "normalized": [] }, { "id": "DS.d1141.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1141.s0.e0", "arg2_id": "DS.d1141.s0.e2", "normalized": [] } ]
DS.d1142
18787978
[ { "id": "DS.d1142.s0", "type": "", "text": [ "Candida albicans and C. tropicalis obtained from whole saliva of patients presenting signs of oral candidosis were assayed for quantification of colony forming units, exoenzyme activity (phospholipase and proteinase) and antifungal drug sensitivity (amphotericin B, fluconazole and itraconazole) by the reference method of the Clinical and Laboratory Standards Institute." ], "offsets": [ [ 0, 371 ] ] } ]
[ { "id": "DS.d1142.s0.e0", "type": "protein", "text": [ "proteinase" ], "offsets": [ [ 205, 215 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10265" }, { "db_name": "UniProt", "db_id": "P63119" }, { "db_name": "UniProt", "db_id": "P63120" }, { "db_name": "UniProt", "db_id": "P63121" }, { "db_name": "UniProt", "db_id": "P63122" }, { "db_name": "UniProt", "db_id": "P63123" }, { "db_name": "UniProt", "db_id": "P63124" }, { "db_name": "UniProt", "db_id": "P63125" }, { "db_name": "UniProt", "db_id": "P63127" }, { "db_name": "UniProt", "db_id": "P63129" }, { "db_name": "UniProt", "db_id": "P63131" }, { "db_name": "UniProt", "db_id": "Q9Y6I0" } ] }, { "id": "DS.d1142.s0.e1", "type": "compound", "text": [ "amphotericin B" ], "offsets": [ [ 250, 264 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280965" } ] }, { "id": "DS.d1142.s0.e2", "type": "compound", "text": [ "fluconazole" ], "offsets": [ [ 266, 277 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3365" } ] }, { "id": "DS.d1142.s0.e3", "type": "compound", "text": [ "itraconazole" ], "offsets": [ [ 282, 294 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3793" }, { "db_name": "PubChem", "db_id": "55283" }, { "db_name": "PubChem", "db_id": "6917738" }, { "db_name": "PubChem", "db_id": "14179013" } ] } ]
[]
[]
[]
DS.d1143
18788036
[ { "id": "DS.d1143.s0", "type": "", "text": [ "To achieve sustained delivery of a novel bone-induced growth factor, chitosan microspheres loaded with synthetic oligopeptide (S((PO4))KIPKASSVPTELSAISTLYLDDD, P24) were prepared by an emulsion-ionic cross-linking method in the presence of tripolyphosphate, with bovine serum albumin (BSA) as a control." ], "offsets": [ [ 0, 303 ] ] } ]
[ { "id": "DS.d1143.s0.e0", "type": "compound", "text": [ "PO4" ], "offsets": [ [ 130, 133 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1061" } ] }, { "id": "DS.d1143.s0.e1", "type": "protein", "text": [ "serum albumin" ], "offsets": [ [ 270, 283 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21847" }, { "db_name": "UniProt", "db_id": "P83517" } ] }, { "id": "DS.d1143.s0.e2", "type": "protein", "text": [ "BSA" ], "offsets": [ [ 285, 288 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02769" } ] } ]
[]
[]
[]
DS.d1144
18789002
[ { "id": "DS.d1144.s0", "type": "", "text": [ "Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3." ], "offsets": [ [ 0, 107 ] ] }, { "id": "DS.d1144.s1", "type": "", "text": [ "This process is associated with an increase in intracellular levels of pyruvate, increase in the acetylation status of histone H4, and enhanced cell death." ], "offsets": [ [ 108, 263 ] ] } ]
[ { "id": "DS.d1144.s0.e0", "type": "compound", "text": [ "pyruvate" ], "offsets": [ [ 42, 50 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1060" } ] }, { "id": "DS.d1144.s0.e1", "type": "protein", "text": [ "HDAC1" ], "offsets": [ [ 95, 100 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P56517" }, { "db_name": "UniProt", "db_id": "P56518" }, { "db_name": "UniProt", "db_id": "Q13547" }, { "db_name": "UniProt", "db_id": "Q94517" } ] }, { "id": "DS.d1144.s0.e2", "type": "protein", "text": [ "HDAC3" ], "offsets": [ [ 101, 106 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15379" }, { "db_name": "UniProt", "db_id": "P56520" } ] }, { "id": "DS.d1144.s1.e0", "type": "compound", "text": [ "pyruvate" ], "offsets": [ [ 179, 187 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1060" } ] }, { "id": "DS.d1144.s1.e1", "type": "protein", "text": [ "histone H4" ], "offsets": [ [ 227, 237 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02309" }, { "db_name": "UniProt", "db_id": "P04914" }, { "db_name": "UniProt", "db_id": "P04915" }, { "db_name": "UniProt", "db_id": "P08436" }, { "db_name": "UniProt", "db_id": "P09322" }, { "db_name": "UniProt", "db_id": "P27996" }, { "db_name": "UniProt", "db_id": "P35057" }, { "db_name": "UniProt", "db_id": "P35059" }, { "db_name": "UniProt", "db_id": "P40287" }, { "db_name": "UniProt", "db_id": "P50566" }, { "db_name": "UniProt", "db_id": "P59259" }, { "db_name": "UniProt", "db_id": "P62776" }, { "db_name": "UniProt", "db_id": "P62777" }, { "db_name": "UniProt", "db_id": "P62778" }, { "db_name": "UniProt", "db_id": "P62779" }, { "db_name": "UniProt", "db_id": "P62780" }, { "db_name": "UniProt", "db_id": "P62781" }, { "db_name": "UniProt", "db_id": "P62782" }, { "db_name": "UniProt", "db_id": "P62783" }, { "db_name": "UniProt", "db_id": "P62784" }, { "db_name": "UniProt", "db_id": "P62787" }, { "db_name": "UniProt", "db_id": "P62788" }, { "db_name": "UniProt", "db_id": "P62789" }, { "db_name": "UniProt", 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"db_name": "UniProt", "db_id": "Q9HDF5" }, { "db_name": "UniProt", "db_id": "Q9U7D0" } ] } ]
[]
[]
[]
DS.d1145
18789341
[ { "id": "DS.d1145.s0", "type": "", "text": [ "The cAMP/protein kinase A (PKA) signaling cascade is crucial for synaptic plasticity in a wide variety of species." ], "offsets": [ [ 0, 114 ] ] } ]
[ { "id": "DS.d1145.s0.e0", "type": "compound", "text": [ "cAMP" ], "offsets": [ [ 4, 8 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6076" } ] }, { "id": "DS.d1145.s0.e1", "type": "protein", "text": [ "protein kinase A" ], "offsets": [ [ 9, 25 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q05608" }, { "db_name": "UniProt", "db_id": "Q9RI12" } ] } ]
[]
[]
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DS.d1146
18789398
[ { "id": "DS.d1146.s0", "type": "", "text": [ "Epigenetic reprogramming of breast cancer cells by valproic acid occurs regardless of estrogen receptor status." ], "offsets": [ [ 0, 111 ] ] } ]
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[]
[]
[]
DS.d1147
18789440
[ { "id": "DS.d1147.s0", "type": "", "text": [ "In the present study, we have investigated the effect of IFN-gamma on ABCA1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells." ], "offsets": [ [ 0, 149 ] ] } ]
[ { "id": "DS.d1147.s0.e0", "type": "protein", "text": [ "IFN-gamma" ], "offsets": [ [ 57, 66 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35497" }, { "db_name": "UniProt", "db_id": "O35735" }, { "db_name": "UniProt", "db_id": "O57571" }, { "db_name": "UniProt", "db_id": "O57603" }, { "db_name": "UniProt", "db_id": "O57608" }, { "db_name": "UniProt", "db_id": "O73915" }, { "db_name": "UniProt", "db_id": "O77763" }, { "db_name": "UniProt", "db_id": "P01579" }, { "db_name": "UniProt", "db_id": "P01580" }, { "db_name": "UniProt", "db_id": "P01581" }, { "db_name": "UniProt", "db_id": "P07353" }, { "db_name": "UniProt", "db_id": "P17773" }, { "db_name": "UniProt", "db_id": "P17803" }, { "db_name": "UniProt", "db_id": "P28333" }, { "db_name": "UniProt", "db_id": "P28341" }, { "db_name": "UniProt", "db_id": "P30123" }, { "db_name": "UniProt", "db_id": "P42160" }, { "db_name": "UniProt", "db_id": "P42161" }, { "db_name": "UniProt", "db_id": "P42162" }, { "db_name": "UniProt", "db_id": "P46402" }, { "db_name": "UniProt", "db_id": "P49708" }, { "db_name": "UniProt", "db_id": "P63309" }, { "db_name": "UniProt", "db_id": "P63310" }, { "db_name": "UniProt", "db_id": "P63311" }, { "db_name": "UniProt", "db_id": "P79154" }, { "db_name": "UniProt", "db_id": "Q1WM28" }, { "db_name": "UniProt", "db_id": "Q25BC0" }, { "db_name": "UniProt", "db_id": "Q2PE75" }, { "db_name": "UniProt", "db_id": "Q4ZH68" }, { "db_name": "UniProt", "db_id": "Q5CCK0" }, { "db_name": "UniProt", "db_id": "Q5I6S9" }, { "db_name": "UniProt", "db_id": "Q62574" }, { "db_name": "UniProt", "db_id": "Q647G2" }, { "db_name": "UniProt", "db_id": "Q7TSP4" }, { "db_name": "UniProt", "db_id": "Q865W6" }, { "db_name": "UniProt", "db_id": "Q865X1" }, { "db_name": "UniProt", "db_id": "Q865Y4" }, { "db_name": "UniProt", "db_id": "Q866Y6" }, { "db_name": "UniProt", "db_id": "Q8MKF5" }, { "db_name": "UniProt", "db_id": "Q8SPW9" }, { "db_name": "UniProt", "db_id": "Q9QXX2" }, { "db_name": "UniProt", "db_id": "Q9TTB0" }, { "db_name": "UniProt", "db_id": "Q9TV67" }, { "db_name": "UniProt", "db_id": "Q9YGB9" } ] }, { "id": "DS.d1147.s0.e1", "type": "protein", "text": [ "ABCA1" ], "offsets": [ [ 70, 75 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O95477" } ] }, { "id": "DS.d1147.s0.e2", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 91, 102 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] } ]
[]
[]
[ { "id": "DS.d1147.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1147.s0.e2", "arg2_id": "DS.d1147.s0.e0", "normalized": [] } ]
DS.d1148
18789466
[ { "id": "DS.d1148.s0", "type": "", "text": [ "Every 12 weeks intestinal permeability (lactulose/mannitol ratio), haemoglobin, plasma albumin, alpha-1-acid glycoprotein, IgG and Giardia-specific IgM (GSIgM) and eggs of the three common geohelminths and G. intestinalis cysts were determined." ], "offsets": [ [ 0, 244 ] ] } ]
[ { "id": "DS.d1148.s0.e0", "type": "compound", "text": [ "lactulose" ], "offsets": [ [ 40, 49 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3872" }, { "db_name": "PubChem", "db_id": "11333" }, { "db_name": "PubChem", "db_id": "11024312" }, { "db_name": "PubChem", "db_id": "16217605" }, { "db_name": "PubChem", "db_id": "16760534" } ] }, { "id": "DS.d1148.s0.e1", "type": "compound", "text": [ "mannitol" ], "offsets": [ [ 50, 58 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6251" } ] }, { "id": "DS.d1148.s0.e2", "type": "protein", "text": [ "alpha-1" ], "offsets": [ [ 96, 103 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q08398" } ] }, { "id": "DS.d1148.s0.e3", "type": "protein", "text": [ "glycoprotein" ], "offsets": [ [ 109, 121 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08163" } ] } ]
[]
[]
[]
DS.d1149
18789492
[ { "id": "DS.d1149.s0", "type": "", "text": [ "As such, the aim of the present study was to investigate whether CETP-inhibition with JTT-705, a molecule distinctly different from torcetrapib, impacts on vascular function, a well-established surrogate of atherosclerotic vascular disease, as well as markers of inflammation and oxidative stress in patients with type II hyperlipidemia." ], "offsets": [ [ 0, 337 ] ] } ]
[ { "id": "DS.d1149.s0.e0", "type": "protein", "text": [ "CETP" ], "offsets": [ [ 65, 69 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11597" }, { "db_name": "UniProt", "db_id": "P22687" }, { "db_name": "UniProt", "db_id": "P25914" }, { "db_name": "UniProt", "db_id": "P47896" } ] }, { "id": "DS.d1149.s0.e1", "type": "compound", "text": [ "JTT-705" ], "offsets": [ [ 86, 93 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6918540" } ] } ]
[]
[]
[ { "id": "DS.d1149.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1149.s0.e1", "arg2_id": "DS.d1149.s0.e0", "normalized": [] } ]
DS.d1150
18789529
[ { "id": "DS.d1150.s0", "type": "", "text": [ "In this review we discuss the membrane proteins that transport arsenic and selenium into cells, from bacteria to humans, as well as some of the efflux proteins involved in detoxification." ], "offsets": [ [ 0, 187 ] ] } ]
[ { "id": "DS.d1150.s0.e0", "type": "protein", "text": [ "membrane proteins" ], "offsets": [ [ 30, 47 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P16629" }, { "db_name": "UniProt", "db_id": "P24266" }, { "db_name": "UniProt", "db_id": "P28991" }, { "db_name": "UniProt", "db_id": "Q04565" }, { "db_name": "UniProt", "db_id": "Q07252" } ] }, { "id": "DS.d1150.s0.e1", "type": "compound", "text": [ "selenium" ], "offsets": [ [ 75, 83 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6326970" } ] } ]
[]
[]
[ { "id": "DS.d1150.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1150.s0.e1", "arg2_id": "DS.d1150.s0.e0", "normalized": [] } ]
DS.d1151
18789530
[ { "id": "DS.d1151.s0", "type": "", "text": [ "Pathways involved in the hydrolysis of nitrile pollutants (aliphatic nitriles, benzonitrile analogues) and the corresponding enzymes (nitrilase, nitrile hydratase) are described in detail." ], "offsets": [ [ 0, 188 ] ] } ]
[ { "id": "DS.d1151.s0.e0", "type": "compound", "text": [ "benzonitrile" ], "offsets": [ [ 79, 91 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7505" } ] }, { "id": "DS.d1151.s0.e1", "type": "protein", "text": [ "nitrilase" ], "offsets": [ [ 134, 143 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13448" }, { "db_name": "UniProt", "db_id": "P13449" }, { "db_name": "UniProt", "db_id": "P27763" }, { "db_name": "UniProt", "db_id": "P27764" }, { "db_name": "UniProt", "db_id": "P33036" }, { "db_name": "UniProt", "db_id": "P82605" }, { "db_name": "UniProt", "db_id": "P97051" }, { "db_name": "UniProt", "db_id": "P97052" }, { "db_name": "UniProt", "db_id": "Q53117" }, { "db_name": "UniProt", "db_id": "Q53118" } ] } ]
[]
[]
[ { "id": "DS.d1151.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1151.s0.e0", "arg2_id": "DS.d1151.s0.e1", "normalized": [] } ]
DS.d1152
18789597
[ { "id": "DS.d1152.s0", "type": "", "text": [ "Since stellate cells have been found to express the beta but not the alpha isoform of the estrogen receptor, it can be predicted that nutritional intakes of the soy isoflavone genistein-a selective agonist for ERbeta in the low nanomolar plasma concentrations achievable with these intakes-have potential for suppressing hepatic fibrosis, in both men and women." ], "offsets": [ [ 0, 361 ] ] } ]
[ { "id": "DS.d1152.s0.e0", "type": "protein", "text": [ "estrogen receptor" ], "offsets": [ [ 90, 107 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42132" }, { "db_name": "UniProt", "db_id": "P03372" }, { "db_name": "UniProt", "db_id": "P06211" }, { "db_name": "UniProt", "db_id": "P06212" }, { "db_name": "UniProt", "db_id": "P16058" }, { "db_name": "UniProt", "db_id": "P19785" }, { "db_name": "UniProt", "db_id": "P49884" }, { "db_name": "UniProt", "db_id": "P49885" }, { "db_name": "UniProt", "db_id": "P49886" }, { "db_name": "UniProt", "db_id": "P50240" }, { "db_name": "UniProt", "db_id": "P50241" }, { "db_name": "UniProt", "db_id": "P50242" }, { "db_name": "UniProt", "db_id": "P57717" }, { "db_name": "UniProt", "db_id": "P57753" }, { "db_name": "UniProt", "db_id": "P81559" }, { "db_name": "UniProt", "db_id": "Q29040" }, { "db_name": "UniProt", "db_id": "Q53AD2" }, { "db_name": "UniProt", "db_id": "Q91250" }, { "db_name": "UniProt", "db_id": "Q91424" }, { "db_name": "UniProt", "db_id": "Q9PVZ9" }, { "db_name": "UniProt", "db_id": "Q9QZJ5" }, { "db_name": "UniProt", "db_id": "Q9TV98" }, { "db_name": "UniProt", "db_id": "Q9YH33" }, { "db_name": "UniProt", "db_id": "Q9YHT3" }, { "db_name": "UniProt", "db_id": "Q9YHZ7" } ] }, { "id": "DS.d1152.s0.e1", "type": "compound", "text": [ "isoflavone" ], "offsets": [ [ 165, 175 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "72304" } ] }, { "id": "DS.d1152.s0.e2", "type": "compound", "text": [ "genistein" ], "offsets": [ [ 176, 185 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280961" } ] } ]
[]
[]
[ { "id": "DS.d1152.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1152.s0.e1", "arg2_id": "DS.d1152.s0.e0", "normalized": [] } ]
DS.d1153
18789664
[ { "id": "DS.d1153.s0", "type": "", "text": [ "We report that the PP inhibition of proteolysis in young rats was mediated by the increased INS secretion and resulted from a down-regulation of both lysosomal and Ca(2+)-dependent proteolysis." ], "offsets": [ [ 0, 193 ] ] } ]
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[]
[]
[]
DS.d1154
18789666
[ { "id": "DS.d1154.s0", "type": "", "text": [ "Aqueous extract of cumin was tested for its antiglycating ability against fructose-induced glycation of goat lens total soluble protein (TSP), alpha-crystallin from goat lens and a nonlenticular protein bovine serum albumin (BSA)." ], "offsets": [ [ 0, 230 ] ] } ]
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[]
[]
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DS.d1155
18789669
[ { "id": "DS.d1155.s0", "type": "", "text": [ "To investigate the effects of selenium on mRNA expressions of proinflammatory cytokines and inducible nitric oxide synthase (iNOS) in the pancreas of streptozotocin-induced diabetic mice, the animals were divided into three groups in this study: a normal control group, an untreated diabetes mellitus group and a selenite-treated diabetes mellitus group." ], "offsets": [ [ 0, 354 ] ] }, { "id": "DS.d1155.s1", "type": "", "text": [ "The results showed that pancreatic selenium content and glutathione peroxidase.05), respectively, in selenite-treated diabetes mellitus group compared with untreated diabetes mellitus group." ], "offsets": [ [ 355, 545 ] ] }, { "id": "DS.d1155.s2", "type": "", "text": [ "Meanwhile, pancreatic mRNA expressions of proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha and interferon-gamma ; mRNA expression and activity of iNOS.05), respectively, in selenite-treated diabetes mellitus group compared with untreated diabetes mellitus group." ], "offsets": [ [ 546, 832 ] ] } ]
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[]
[]
[ { "id": "DS.d1155.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1155.s0.e0", "arg2_id": "DS.d1155.s0.e1", "normalized": [] }, { "id": "DS.d1155.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1155.s0.e0", "arg2_id": "DS.d1155.s0.e2", "normalized": [] }, { "id": "DS.d1155.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1155.s2.e3", "arg2_id": "DS.d1155.s2.e0", "normalized": [] }, { "id": "DS.d1155.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1155.s2.e3", "arg2_id": "DS.d1155.s2.e2", "normalized": [] }, { "id": "DS.d1155.s2.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1155.s2.e3", "arg2_id": "DS.d1155.s2.e1", "normalized": [] } ]
DS.d1156
18789733
[ { "id": "DS.d1156.s0", "type": "", "text": [ "Decreases in PNNs, aggrecan and hyaluronic acid were observed only in the terminal stages and correlated with the distribution of PrP (BSE) and activated glial cells." ], "offsets": [ [ 0, 166 ] ] }, { "id": "DS.d1156.s1", "type": "", "text": [ "This study suggests that the loss of PNNs, aggrecan and hyaluronic acid is a consequence of PrP (BSE) accumulation." ], "offsets": [ [ 167, 282 ] ] } ]
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"db_name": "UniProt", "db_id": "P67988" }, { "db_name": "UniProt", "db_id": "P67989" }, { "db_name": "UniProt", "db_id": "P67990" }, { "db_name": "UniProt", "db_id": "P67991" }, { "db_name": "UniProt", "db_id": "P67992" }, { "db_name": "UniProt", "db_id": "P67993" }, { "db_name": "UniProt", "db_id": "P67994" }, { "db_name": "UniProt", "db_id": "P67995" }, { "db_name": "UniProt", "db_id": "P67996" }, { "db_name": "UniProt", "db_id": "P67997" }, { "db_name": "UniProt", "db_id": "P79141" }, { "db_name": "UniProt", "db_id": "Q5UAF1" }, { "db_name": "UniProt", "db_id": "Q5UJG1" }, { "db_name": "UniProt", "db_id": "Q5UJG3" }, { "db_name": "UniProt", "db_id": "Q5UJG7" }, { "db_name": "UniProt", "db_id": "Q5UJH0" }, { "db_name": "UniProt", "db_id": "Q5UJH8" }, { "db_name": "UniProt", "db_id": "Q5UJI7" }, { "db_name": "UniProt", "db_id": "Q5XVM4" }, { "db_name": "UniProt", "db_id": "Q60468" }, { "db_name": "UniProt", "db_id": "Q60506" }, { "db_name": "UniProt", "db_id": "Q68G95" }, { "db_name": "UniProt", "db_id": "Q6EH52" }, { "db_name": "UniProt", "db_id": "Q7JIH3" }, { "db_name": "UniProt", "db_id": "Q7JIY2" }, { "db_name": "UniProt", "db_id": "Q7JK02" }, { "db_name": "UniProt", "db_id": "Q95174" }, { "db_name": "UniProt", "db_id": "Q95176" }, { "db_name": "UniProt", "db_id": "Q95211" }, { "db_name": "UniProt", "db_id": "Q95270" }, { "db_name": "UniProt", "db_id": "Q95M08" }, { "db_name": "UniProt", "db_id": "Q9Z0T3" } ] }, { "id": "DS.d1156.s1.e0", "type": "protein", "text": [ "PNNs" ], "offsets": [ [ 204, 208 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P79122" }, { "db_name": "UniProt", "db_id": "P79149" }, { "db_name": "UniProt", "db_id": "Q5R5X0" }, { "db_name": "UniProt", "db_id": "Q9H307" } ] }, { "id": "DS.d1156.s1.e1", "type": "compound", "text": [ "hyaluronic acid" ], "offsets": [ [ 223, 238 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24759" }, { "db_name": "PubChem", "db_id": "453618" }, { "db_name": "PubChem", "db_id": "3084050" }, { "db_name": "PubChem", "db_id": "24728612" } ] }, { "id": "DS.d1156.s1.e2", "type": "protein", "text": [ "PrP" ], "offsets": [ [ 259, 262 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18754" }, { "db_name": "UniProt", "db_id": "O46501" }, { "db_name": "UniProt", "db_id": "P04156" }, { "db_name": "UniProt", "db_id": "P04273" }, { "db_name": "UniProt", "db_id": "P04925" }, { "db_name": "UniProt", "db_id": "P10279" }, { "db_name": "UniProt", "db_id": "P13852" }, { "db_name": "UniProt", "db_id": "P23907" }, { "db_name": "UniProt", "db_id": "P40242" }, { "db_name": "UniProt", "db_id": "P40243" }, { "db_name": "UniProt", "db_id": "P40244" }, { "db_name": "UniProt", "db_id": "P40245" }, { "db_name": "UniProt", "db_id": "P40246" }, { "db_name": "UniProt", "db_id": "P40247" }, { "db_name": "UniProt", "db_id": "P40248" }, { "db_name": "UniProt", "db_id": "P40249" }, { "db_name": "UniProt", "db_id": "P40251" }, { "db_name": "UniProt", "db_id": "P40252" }, { "db_name": "UniProt", "db_id": "P40255" }, { "db_name": "UniProt", "db_id": "P40256" }, { "db_name": "UniProt", "db_id": "P40257" }, { "db_name": "UniProt", "db_id": "P40258" }, { "db_name": "UniProt", "db_id": "P47852" }, { "db_name": "UniProt", "db_id": "P49927" }, { "db_name": "UniProt", "db_id": "P51446" }, { "db_name": "UniProt", "db_id": "P51780" }, { "db_name": "UniProt", "db_id": "P52113" }, { "db_name": "UniProt", "db_id": "P52114" }, { "db_name": "UniProt", "db_id": "P61761" }, { "db_name": "UniProt", "db_id": "P61762" }, { "db_name": "UniProt", "db_id": "P61766" }, { "db_name": "UniProt", "db_id": "P61767" }, { "db_name": "UniProt", "db_id": "P61768" }, { "db_name": "UniProt", "db_id": "P67986" }, { "db_name": "UniProt", "db_id": "P67987" }, { "db_name": "UniProt", "db_id": "P67988" }, { "db_name": "UniProt", "db_id": "P67989" }, { "db_name": "UniProt", "db_id": "P67990" }, { "db_name": "UniProt", "db_id": "P67991" }, { "db_name": "UniProt", "db_id": "P67992" }, { "db_name": "UniProt", "db_id": "P67993" }, { "db_name": "UniProt", "db_id": "P67994" }, { "db_name": "UniProt", "db_id": "P67995" }, { "db_name": "UniProt", "db_id": "P67996" }, { "db_name": "UniProt", "db_id": "P67997" }, { "db_name": "UniProt", "db_id": "P79141" }, { "db_name": "UniProt", "db_id": "Q5UAF1" }, { "db_name": "UniProt", "db_id": "Q5UJG1" }, { "db_name": "UniProt", "db_id": "Q5UJG3" }, { "db_name": "UniProt", "db_id": "Q5UJG7" }, { "db_name": "UniProt", "db_id": "Q5UJH0" }, { "db_name": "UniProt", "db_id": "Q5UJH8" }, { "db_name": "UniProt", "db_id": "Q5UJI7" }, { "db_name": "UniProt", "db_id": "Q5XVM4" }, { "db_name": "UniProt", "db_id": "Q60468" }, { "db_name": "UniProt", "db_id": "Q60506" }, { "db_name": "UniProt", "db_id": "Q68G95" }, { "db_name": "UniProt", "db_id": "Q6EH52" }, { "db_name": "UniProt", "db_id": "Q7JIH3" }, { "db_name": "UniProt", "db_id": "Q7JIY2" }, { "db_name": "UniProt", "db_id": "Q7JK02" }, { "db_name": "UniProt", "db_id": "Q95174" }, { "db_name": "UniProt", "db_id": "Q95176" }, { "db_name": "UniProt", "db_id": "Q95211" }, { "db_name": "UniProt", "db_id": "Q95270" }, { "db_name": "UniProt", "db_id": "Q95M08" }, { "db_name": "UniProt", "db_id": "Q9Z0T3" } ] } ]
[]
[]
[ { "id": "DS.d1156.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1156.s0.e0", "arg2_id": "DS.d1156.s0.e1", "normalized": [] } ]
DS.d1157
18789802
[ { "id": "DS.d1157.s0", "type": "", "text": [ "Cells were exposed to native low-density lipoprotein (LDL), acetylated LDL, and LDL that had been modified by oxidation with copper or ferrous ions or by exposure to auto-oxidation products of arachidonic acid for 16h, and VEGF was then assayed in medium." ], "offsets": [ [ 0, 255 ] ] } ]
[ { "id": "DS.d1157.s0.e0", "type": "compound", "text": [ "copper" ], "offsets": [ [ 125, 131 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23978" } ] }, { "id": "DS.d1157.s0.e1", "type": "compound", "text": [ "ferrous ions" ], "offsets": [ [ 135, 147 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "27284" } ] }, { "id": "DS.d1157.s0.e2", "type": "compound", "text": [ "arachidonic acid" ], "offsets": [ [ 193, 209 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444899" } ] }, { "id": "DS.d1157.s0.e3", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 223, 227 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] } ]
[]
[]
[]
DS.d1158
18789953
[ { "id": "DS.d1158.s0", "type": "", "text": [ "In hypersensitive alpha4L9'A mice, injections of a low dose of nicotine (0.1 mg/kg) led to strong c-fos expression in only the ventrolateral region of the MHb, but not in the MHb of wild-type (WT) mice." ], "offsets": [ [ 0, 202 ] ] } ]
[ { "id": "DS.d1158.s0.e0", "type": "compound", "text": [ "nicotine" ], "offsets": [ [ 63, 71 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "942" }, { "db_name": "PubChem", "db_id": "89594" }, { "db_name": "PubChem", "db_id": "157672" } ] }, { "id": "DS.d1158.s0.e1", "type": "protein", "text": [ "fos" ], "offsets": [ [ 100, 103 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01101" }, { "db_name": "UniProt", "db_id": "P12841" }, { "db_name": "UniProt", "db_id": "Q56415" } ] } ]
[]
[]
[ { "id": "DS.d1158.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1158.s0.e0", "arg2_id": "DS.d1158.s0.e1", "normalized": [] } ]
DS.d1159
18790021
[ { "id": "DS.d1159.s0", "type": "", "text": [ "To address this issue, we have examined the effects of excitotoxic lesion of CM/Pf and of 6-hydroxydopamine-induced lesion of nigral dopamine neurons, separately or in association, on gene expression of markers of neuronal activity in the rat basal ganglia (striatal neuropeptide precursors, GAD67, cytochrome oxidase subunit I) by quantitative in situ hybridization histochemistry." ], "offsets": [ [ 0, 382 ] ] } ]
[ { "id": "DS.d1159.s0.e0", "type": "compound", "text": [ "6-hydroxydopamine" ], "offsets": [ [ 90, 107 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4624" } ] }, { "id": "DS.d1159.s0.e1", "type": "protein", "text": [ "neuropeptide" ], "offsets": [ [ 267, 279 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21259" } ] }, { "id": "DS.d1159.s0.e2", "type": "protein", "text": [ "GAD67" ], "offsets": [ [ 292, 297 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14748" }, { "db_name": "UniProt", "db_id": "P48319" }, { "db_name": "UniProt", "db_id": "Q5IS68" }, { "db_name": "UniProt", "db_id": "Q99259" } ] }, { "id": "DS.d1159.s0.e3", "type": "protein", "text": [ "cytochrome oxidase subunit I" ], "offsets": [ [ 299, 327 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P45021" } ] } ]
[]
[]
[ { "id": "DS.d1159.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1159.s0.e0", "arg2_id": "DS.d1159.s0.e1", "normalized": [] }, { "id": "DS.d1159.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1159.s0.e0", "arg2_id": "DS.d1159.s0.e3", "normalized": [] }, { "id": "DS.d1159.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1159.s0.e0", "arg2_id": "DS.d1159.s0.e2", "normalized": [] } ]
DS.d1160
18790083
[ { "id": "DS.d1160.s0", "type": "", "text": [ "Participating in a significant fraction of the fundamental paths connecting the ligands to the phenotypes, cofactor GTP and complex Gbeta/Ggamma were identified as \"housekeeping\" molecules, through which all pathways of EGFR network are cross-talking." ], "offsets": [ [ 0, 251 ] ] } ]
[ { "id": "DS.d1160.s0.e0", "type": "compound", "text": [ "GTP" ], "offsets": [ [ 116, 119 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6830" } ] }, { "id": "DS.d1160.s0.e1", "type": "protein", "text": [ "EGFR" ], "offsets": [ [ 220, 224 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00533" }, { "db_name": "UniProt", "db_id": "P13387" }, { "db_name": "UniProt", "db_id": "P55245" } ] } ]
[]
[]
[ { "id": "DS.d1160.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1160.s0.e0", "arg2_id": "DS.d1160.s0.e1", "normalized": [] } ]
DS.d1161
18790533
[ { "id": "DS.d1161.s0", "type": "", "text": [ "These effects were probably associated with the increase of intracellular superoxide in mitochondrial signaling pathway which attributed to the down-regulation of superoxide dismutase (SOD)." ], "offsets": [ [ 0, 190 ] ] } ]
[ { "id": "DS.d1161.s0.e0", "type": "compound", "text": [ "superoxide" ], "offsets": [ [ 74, 84 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5359597" } ] }, { "id": "DS.d1161.s0.e1", "type": "protein", "text": [ "superoxide dismutase" ], "offsets": [ [ 163, 183 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] }, { "id": "DS.d1161.s0.e2", "type": "protein", "text": [ "SOD" ], "offsets": [ [ 185, 188 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12933" }, { "db_name": "UniProt", "db_id": "O22668" }, { "db_name": "UniProt", "db_id": "O75007" }, { "db_name": "UniProt", "db_id": "P24705" }, { "db_name": "UniProt", "db_id": "P51547" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q01137" }, { "db_name": "UniProt", "db_id": "Q27666" }, { "db_name": "UniProt", "db_id": "Q9SM64" } ] } ]
[]
[]
[ { "id": "DS.d1161.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1161.s0.e0", "arg2_id": "DS.d1161.s0.e1", "normalized": [] }, { "id": "DS.d1161.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1161.s0.e0", "arg2_id": "DS.d1161.s0.e2", "normalized": [] } ]
DS.d1162
18790812
[ { "id": "DS.d1162.s0", "type": "", "text": [ "This initiates a cAMP signalling cascade resulting in the translocation of AQP2-bearing vesicles to the apical membrane." ], "offsets": [ [ 0, 120 ] ] } ]
[ { "id": "DS.d1162.s0.e0", "type": "compound", "text": [ "cAMP" ], "offsets": [ [ 17, 21 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6076" } ] }, { "id": "DS.d1162.s0.e1", "type": "protein", "text": [ "AQP2" ], "offsets": [ [ 75, 79 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62735" }, { "db_name": "UniProt", "db_id": "O77697" }, { "db_name": "UniProt", "db_id": "O77714" }, { "db_name": "UniProt", "db_id": "O77722" }, { "db_name": "UniProt", "db_id": "O77740" }, { "db_name": "UniProt", "db_id": "P41181" }, { "db_name": "UniProt", "db_id": "P79099" }, { "db_name": "UniProt", "db_id": "P79144" }, { "db_name": "UniProt", "db_id": "P79164" }, { "db_name": "UniProt", "db_id": "P79165" }, { "db_name": "UniProt", "db_id": "P79168" }, { "db_name": "UniProt", "db_id": "P79200" }, { "db_name": "UniProt", "db_id": "P79213" }, { "db_name": "UniProt", "db_id": "P79229" }, { "db_name": "UniProt", "db_id": "P79803" } ] } ]
[]
[]
[ { "id": "DS.d1162.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1162.s0.e0", "arg2_id": "DS.d1162.s0.e1", "normalized": [] } ]
DS.d1163
18790996
[ { "id": "DS.d1163.s0", "type": "", "text": [ "The formation and trafficking of autophagic vesicles are directed in part by associated conjugation cascades that couple the AUTOPHAGY-RELATED8 (ATG8) and ATG12 proteins to their respective targets, phosphatidylethanolamine and the ATG5 protein." ], "offsets": [ [ 0, 245 ] ] }, { "id": "DS.d1163.s1", "type": "", "text": [ "Levels of Atg transcripts and/or the ATG8-phosphatidylethanolamine adduct increase during leaf senescence and nitrogen and fixed-carbon limitations, indicating that autophagy plays a key role in nutrient remobilization." ], "offsets": [ [ 246, 465 ] ] } ]
[ { "id": "DS.d1163.s0.e0", "type": "protein", "text": [ "ATG8" ], "offsets": [ [ 145, 149 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0C075" }, { "db_name": "UniProt", "db_id": "P38182" }, { "db_name": "UniProt", "db_id": "P87068" }, { "db_name": "UniProt", "db_id": "Q4P2U6" }, { "db_name": "UniProt", "db_id": "Q51MW4" }, { "db_name": "UniProt", "db_id": "Q5KN30" }, { "db_name": "UniProt", "db_id": "Q5QFG1" }, { "db_name": "UniProt", "db_id": "Q6BT31" }, { "db_name": "UniProt", "db_id": "Q6C794" }, { "db_name": "UniProt", "db_id": "Q6CMF8" }, { "db_name": "UniProt", "db_id": "Q6FXR8" }, { "db_name": "UniProt", "db_id": "Q755X2" }, { "db_name": "UniProt", "db_id": "Q8H715" }, { "db_name": "UniProt", "db_id": "Q8J282" }, { "db_name": "UniProt", "db_id": "Q8NJJ4" } ] }, { "id": "DS.d1163.s0.e1", "type": "protein", "text": [ "ATG12" ], "offsets": [ [ 155, 160 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O94817" }, { "db_name": "UniProt", "db_id": "P38316" }, { "db_name": "UniProt", "db_id": "Q3T0W7" }, { "db_name": "UniProt", "db_id": "Q51P78" }, { "db_name": "UniProt", "db_id": "Q55S70" }, { "db_name": "UniProt", "db_id": "Q5AKU4" }, { "db_name": "UniProt", "db_id": "Q5R7W1" }, { "db_name": "UniProt", "db_id": "Q69NP0" }, { "db_name": "UniProt", "db_id": "Q6BU30" }, { "db_name": "UniProt", "db_id": "Q6BZZ1" }, { "db_name": "UniProt", "db_id": "Q6CUD5" }, { "db_name": "UniProt", "db_id": "Q6FMM7" }, { "db_name": "UniProt", "db_id": "Q75EB4" } ] }, { "id": "DS.d1163.s0.e2", "type": "compound", "text": [ "phosphatidylethanolamine" ], "offsets": [ [ 199, 223 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "114944" } ] }, { "id": "DS.d1163.s0.e3", "type": "protein", "text": [ "ATG5" ], "offsets": [ [ 232, 236 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q12380" }, { "db_name": "UniProt", "db_id": "Q3MQ04" }, { "db_name": "UniProt", "db_id": "Q3MQ24" }, { "db_name": "UniProt", "db_id": "Q525E4" }, { "db_name": "UniProt", "db_id": "Q59VY1" }, { "db_name": "UniProt", "db_id": "Q5K6S9" }, { "db_name": "UniProt", "db_id": "Q5R792" }, { "db_name": "UniProt", "db_id": "Q6BVI8" }, { "db_name": "UniProt", "db_id": "Q6C4Q6" }, { "db_name": "UniProt", "db_id": "Q6CKE2" }, { "db_name": "UniProt", "db_id": "Q6FJZ6" }, { "db_name": "UniProt", "db_id": "Q6ZGL4" }, { "db_name": "UniProt", "db_id": "Q75BY9" }, { "db_name": "UniProt", "db_id": "Q9FFI2" }, { "db_name": "UniProt", "db_id": "Q9H1Y0" } ] }, { "id": "DS.d1163.s1.e0", "type": "protein", "text": [ "ATG8" ], "offsets": [ [ 283, 287 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0C075" }, { "db_name": "UniProt", "db_id": "P38182" }, { "db_name": "UniProt", "db_id": "P87068" }, { "db_name": "UniProt", "db_id": "Q4P2U6" }, { "db_name": "UniProt", "db_id": "Q51MW4" }, { "db_name": "UniProt", "db_id": "Q5KN30" }, { "db_name": "UniProt", "db_id": "Q5QFG1" }, { "db_name": "UniProt", "db_id": "Q6BT31" }, { "db_name": "UniProt", "db_id": "Q6C794" }, { "db_name": "UniProt", "db_id": "Q6CMF8" }, { "db_name": "UniProt", "db_id": "Q6FXR8" }, { "db_name": "UniProt", "db_id": "Q755X2" }, { "db_name": "UniProt", "db_id": "Q8H715" }, { "db_name": "UniProt", "db_id": "Q8J282" }, { "db_name": "UniProt", "db_id": "Q8NJJ4" } ] }, { "id": "DS.d1163.s1.e1", "type": "compound", "text": [ "phosphatidylethanolamine" ], "offsets": [ [ 288, 312 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "114944" } ] } ]
[]
[]
[ { "id": "DS.d1163.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1163.s0.e2", "arg2_id": "DS.d1163.s0.e0", "normalized": [] }, { "id": "DS.d1163.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1163.s0.e2", "arg2_id": "DS.d1163.s0.e1", "normalized": [] }, { "id": "DS.d1163.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1163.s1.e1", "arg2_id": "DS.d1163.s1.e0", "normalized": [] } ]
DS.d1164
18791141
[ { "id": "DS.d1164.s0", "type": "", "text": [ "This study confirmed QTL previously identified for pH except those on SSC1, 11, 12, and X, and found 11 new 5% genome-wise significant QTL for glycogen-related traits." ], "offsets": [ [ 0, 167 ] ] } ]
[ { "id": "DS.d1164.s0.e0", "type": "protein", "text": [ "SSC1" ], "offsets": [ [ 70, 74 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O43315" }, { "db_name": "UniProt", "db_id": "P12398" }, { "db_name": "UniProt", "db_id": "Q9BW60" } ] }, { "id": "DS.d1164.s0.e1", "type": "compound", "text": [ "glycogen" ], "offsets": [ [ 143, 151 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439177" } ] } ]
[]
[]
[]
DS.d1165
18791145
[ { "id": "DS.d1165.s0", "type": "", "text": [ "The objective of this study was to examine the effect of level and duration of feeding of an n-3 PUFA-enriched fish oil (FO) supplement in combination with soybean oil (SO) on the transcriptional regulation of Delta(9)-desaturase gene expression in bovine muscle." ], "offsets": [ [ 0, 263 ] ] } ]
[ { "id": "DS.d1165.s0.e0", "type": "compound", "text": [ "FO" ], "offsets": [ [ 121, 123 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "46209" }, { "db_name": "PubChem", "db_id": "69711" } ] }, { "id": "DS.d1165.s0.e1", "type": "protein", "text": [ "Delta(9)-desaturase" ], "offsets": [ [ 210, 229 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00767" }, { "db_name": "UniProt", "db_id": "O02858" }, { "db_name": "UniProt", "db_id": "O62849" }, { "db_name": "UniProt", "db_id": "O94523" }, { "db_name": "UniProt", "db_id": "Q12618" }, { "db_name": "UniProt", "db_id": "Q64420" }, { "db_name": "UniProt", "db_id": "Q92038" }, { "db_name": "UniProt", "db_id": "Q95MI7" }, { "db_name": "UniProt", "db_id": "Q9TT94" } ] } ]
[]
[]
[ { "id": "DS.d1165.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1165.s0.e0", "arg2_id": "DS.d1165.s0.e1", "normalized": [] } ]
DS.d1166
18791154
[ { "id": "DS.d1166.s0", "type": "", "text": [ "Whole blood and plasma were analyzed for total Se, glutathione peroxidase activity in whole blood (GPX-1) and plasma, and thyroid hormones (thyroxine and triiodothyronine) in plasma." ], "offsets": [ [ 0, 182 ] ] } ]
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[]
[]
[]
DS.d1167
18791496
[ { "id": "DS.d1167.s0", "type": "", "text": [ "Studies have shown that administration of 17beta-estradiol (estrogen) after trauma-hemorrhage normalized cardiac IL-6 levels and restored cardiac functions under those conditions." ], "offsets": [ [ 0, 179 ] ] } ]
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[]
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DS.d1168
18791811
[ { "id": "DS.d1168.s0", "type": "", "text": [ "Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathways." ], "offsets": [ [ 0, 130 ] ] } ]
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[]
[]
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DS.d1169
18791821
[ { "id": "DS.d1169.s0", "type": "", "text": [ "Epirubicin plus low-dose trastuzumab in HER2 positive metastatic breast cancer." ], "offsets": [ [ 0, 79 ] ] }, { "id": "DS.d1169.s1", "type": "", "text": [ "This phase II study, evaluated the activity and cardiotoxicity of first-line epirubicin plus low-dose trastuzumab (LD-T) in patients with HER2 positive MBC." ], "offsets": [ [ 80, 236 ] ] } ]
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[]
[]
[]
DS.d1171
18791914
[ { "id": "DS.d1171.s0", "type": "", "text": [ "The DEP-induced increases in peribronchial eosinophils and mucous goblet cells in the lung tissues, and of IL-5 and IL-13 in the BAL fluid, were significantly attenuated by the antioxidant N-acetylcysteine." ], "offsets": [ [ 0, 206 ] ] } ]
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[]
[]
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DS.d1172
18792056
[ { "id": "DS.d1172.s0", "type": "", "text": [ "Each of the developed consortium has a phosphate solubilizer, nitrogen fixer, growth hormone producer, heterotrophic member and an antagonist." ], "offsets": [ [ 0, 142 ] ] } ]
[ { "id": "DS.d1172.s0.e0", "type": "compound", "text": [ "phosphate" ], "offsets": [ [ 39, 48 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1061" }, { "db_name": "PubChem", "db_id": "167704" }, { "db_name": "PubChem", "db_id": "644102" } ] }, { "id": "DS.d1172.s0.e1", "type": "compound", "text": [ "nitrogen" ], "offsets": [ [ 62, 70 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "947" }, { "db_name": "PubChem", "db_id": "123329" } ] }, { "id": "DS.d1172.s0.e2", "type": "protein", "text": [ "growth hormone" ], "offsets": [ [ 78, 92 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12980" }, { "db_name": "UniProt", "db_id": "O13188" }, { "db_name": "UniProt", "db_id": "O18938" }, { "db_name": "UniProt", "db_id": "O62754" }, { "db_name": "UniProt", "db_id": "O70615" }, { "db_name": "UniProt", "db_id": "O73848" }, { "db_name": "UniProt", "db_id": "O73849" }, { "db_name": "UniProt", "db_id": "O93566" }, { "db_name": "UniProt", "db_id": "P01241" }, { "db_name": "UniProt", "db_id": "P01244" }, { "db_name": "UniProt", "db_id": "P01245" }, { "db_name": "UniProt", "db_id": "P01246" }, { "db_name": "UniProt", "db_id": "P01248" }, { "db_name": "UniProt", "db_id": "P06880" }, { "db_name": "UniProt", "db_id": "P07064" }, { "db_name": "UniProt", "db_id": "P08591" }, { "db_name": "UniProt", "db_id": "P08998" }, { "db_name": "UniProt", "db_id": "P09113" }, { "db_name": "UniProt", "db_id": "P09537" }, { "db_name": "UniProt", "db_id": "P09539" }, { "db_name": "UniProt", "db_id": "P10298" }, { "db_name": "UniProt", "db_id": "P10607" }, { "db_name": "UniProt", "db_id": "P10766" }, { "db_name": "UniProt", "db_id": "P10813" }, { "db_name": "UniProt", "db_id": "P10814" }, { "db_name": "UniProt", "db_id": "P11228" }, { "db_name": "UniProt", "db_id": "P13391" }, { "db_name": "UniProt", "db_id": "P19795" }, { "db_name": "UniProt", "db_id": "P20391" }, { "db_name": "UniProt", "db_id": "P20392" }, { "db_name": "UniProt", "db_id": "P22077" }, { "db_name": "UniProt", "db_id": "P24363" }, { "db_name": "UniProt", "db_id": "P29971" }, { "db_name": "UniProt", "db_id": "P33092" }, { "db_name": "UniProt", "db_id": "P33093" }, { "db_name": "UniProt", "db_id": "P33711" }, { "db_name": "UniProt", "db_id": "P34005" }, { "db_name": "UniProt", "db_id": "P34006" }, { "db_name": "UniProt", "db_id": "P34744" }, { "db_name": "UniProt", "db_id": "P34745" }, { "db_name": "UniProt", "db_id": "P34746" }, { "db_name": "UniProt", "db_id": "P34747" }, { "db_name": "UniProt", "db_id": "P37885" }, { "db_name": "UniProt", "db_id": "P37886" }, { "db_name": "UniProt", "db_id": "P45643" }, { "db_name": "UniProt", "db_id": "P45654" }, { "db_name": "UniProt", "db_id": "P45655" }, { "db_name": "UniProt", "db_id": "P46404" }, { "db_name": "UniProt", "db_id": "P46407" }, { "db_name": "UniProt", "db_id": "P48248" }, { "db_name": "UniProt", "db_id": "P55755" }, { "db_name": "UniProt", "db_id": "P56437" }, { "db_name": "UniProt", "db_id": "P58343" }, { "db_name": "UniProt", "db_id": "P58756" }, { "db_name": "UniProt", "db_id": "P67930" }, { "db_name": "UniProt", "db_id": "P67931" }, { "db_name": "UniProt", "db_id": "P69158" }, { "db_name": "UniProt", "db_id": "P69159" }, { "db_name": "UniProt", "db_id": "P69160" }, { "db_name": "UniProt", "db_id": "P69161" }, { "db_name": "UniProt", "db_id": "P69162" }, { "db_name": "UniProt", "db_id": "P79885" }, { "db_name": "UniProt", "db_id": "P87391" }, { "db_name": "UniProt", "db_id": "Q01282" }, { "db_name": "UniProt", "db_id": "Q01283" }, { "db_name": "UniProt", "db_id": "Q05163" }, { "db_name": "UniProt", "db_id": "Q07221" }, { "db_name": "UniProt", "db_id": "Q1HFN3" }, { "db_name": "UniProt", "db_id": "Q659Q8" }, { "db_name": "UniProt", "db_id": "Q7YQB8" }, { "db_name": "UniProt", "db_id": "Q7YQD2" }, { "db_name": "UniProt", "db_id": "Q7YRR6" }, { "db_name": "UniProt", "db_id": "Q864S7" }, { "db_name": "UniProt", "db_id": "Q8HYE5" }, { "db_name": "UniProt", "db_id": "Q8MI73" }, { "db_name": "UniProt", "db_id": "Q98UF6" }, { "db_name": "UniProt", "db_id": "Q9DEV3" }, { "db_name": "UniProt", "db_id": "Q9DGG5" }, { "db_name": "UniProt", "db_id": "Q9GKA1" }, { "db_name": "UniProt", "db_id": "Q9GL60" }, { "db_name": "UniProt", "db_id": "Q9GMB2" }, { "db_name": "UniProt", "db_id": "Q9GMB3" }, { "db_name": "UniProt", "db_id": "Q9I9L5" }, { "db_name": "UniProt", "db_id": "Q9I9M4" }, { "db_name": "UniProt", "db_id": "Q9IB11" }, { "db_name": "UniProt", "db_id": "Q9IBE5" }, { "db_name": "UniProt", "db_id": "Q9JKM4" }, { "db_name": "UniProt", "db_id": "Q9PWG3" }, { "db_name": "UniProt", "db_id": "Q9W6J5" }, { "db_name": "UniProt", "db_id": "Q9W6J7" }, { "db_name": "UniProt", "db_id": "Q9W6R8" } ] } ]
[]
[]
[]
DS.d1173
18792785
[ { "id": "DS.d1173.s0", "type": "", "text": [ "Using cannabinoid receptor antagonists and cannabinoid receptor gene deficient mice (CB(1) (-/-) and CB(2) (-/-)), we showed that both CB(1) and CB(2) receptors were involved in the THC-induced attenuation of serum IL-12 and IFNgamma." ], "offsets": [ [ 0, 234 ] ] } ]
[ { "id": "DS.d1173.s0.e0", "type": "compound", "text": [ "THC" ], "offsets": [ [ 182, 185 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "134740" } ] }, { "id": "DS.d1173.s0.e1", "type": "protein", "text": [ "IFNgamma" ], "offsets": [ [ 225, 233 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35497" }, { "db_name": "UniProt", "db_id": "O35735" }, { "db_name": "UniProt", "db_id": "O57571" }, { "db_name": "UniProt", "db_id": "O57603" }, { "db_name": "UniProt", "db_id": "O57608" }, { "db_name": "UniProt", "db_id": "O73915" }, { "db_name": "UniProt", "db_id": "O77763" }, { "db_name": "UniProt", "db_id": "P01579" }, { "db_name": "UniProt", "db_id": "P01580" }, { "db_name": "UniProt", "db_id": "P01581" }, { "db_name": "UniProt", "db_id": "P07353" }, { "db_name": "UniProt", "db_id": "P17773" }, { "db_name": "UniProt", "db_id": "P17803" }, { "db_name": "UniProt", "db_id": "P28333" }, { "db_name": "UniProt", "db_id": "P28341" }, { "db_name": "UniProt", "db_id": "P30123" }, { "db_name": "UniProt", "db_id": "P42160" }, { "db_name": "UniProt", "db_id": "P42161" }, { "db_name": "UniProt", "db_id": "P42162" }, { "db_name": "UniProt", "db_id": "P46402" }, { "db_name": "UniProt", "db_id": "P49708" }, { "db_name": "UniProt", "db_id": "P63309" }, { "db_name": "UniProt", "db_id": "P63310" }, { "db_name": "UniProt", "db_id": "P63311" }, { "db_name": "UniProt", "db_id": "P79154" }, { "db_name": "UniProt", "db_id": "Q1WM28" }, { "db_name": "UniProt", "db_id": "Q25BC0" }, { "db_name": "UniProt", "db_id": "Q2PE75" }, { "db_name": "UniProt", "db_id": "Q4ZH68" }, { "db_name": "UniProt", "db_id": "Q5CCK0" }, { "db_name": "UniProt", "db_id": "Q5I6S9" }, { "db_name": "UniProt", "db_id": "Q62574" }, { "db_name": "UniProt", "db_id": "Q647G2" }, { "db_name": "UniProt", "db_id": "Q7TSP4" }, { "db_name": "UniProt", "db_id": "Q865W6" }, { "db_name": "UniProt", "db_id": "Q865X1" }, { "db_name": "UniProt", "db_id": "Q865Y4" }, { "db_name": "UniProt", "db_id": "Q866Y6" }, { "db_name": "UniProt", "db_id": "Q8MKF5" }, { "db_name": "UniProt", "db_id": "Q8SPW9" }, { "db_name": "UniProt", "db_id": "Q9QXX2" }, { "db_name": "UniProt", "db_id": "Q9TTB0" }, { "db_name": "UniProt", "db_id": "Q9TV67" }, { "db_name": "UniProt", "db_id": "Q9YGB9" } ] } ]
[]
[]
[]
DS.d1174
18792801
[ { "id": "DS.d1174.s0", "type": "", "text": [ "Promoter analysis of the PSG1, 4, and 11 genes in HeLa cells did not reveal a cis-regulatory element responsive to 5-bromodeoxyuridine in their 5'-flanking sequences." ], "offsets": [ [ 0, 166 ] ] } ]
[ { "id": "DS.d1174.s0.e0", "type": "protein", "text": [ "PSG1" ], "offsets": [ [ 25, 29 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11464" } ] }, { "id": "DS.d1174.s0.e1", "type": "compound", "text": [ "5-bromodeoxyuridine" ], "offsets": [ [ 115, 134 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6035" } ] } ]
[]
[]
[]
DS.d1175
18792915
[ { "id": "DS.d1175.s0", "type": "", "text": [ "p38-MAPK- and caspase-3-mediated superoxide-induced apoptosis of rat hepatic stellate cells: reversal by retinoic acid." ], "offsets": [ [ 0, 119 ] ] } ]
[ { "id": "DS.d1175.s0.e0", "type": "protein", "text": [ "p38-MAPK" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62618" } ] }, { "id": "DS.d1175.s0.e1", "type": "compound", "text": [ "retinoic acid" ], "offsets": [ [ 105, 118 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444795" } ] } ]
[]
[]
[ { "id": "DS.d1175.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1175.s0.e1", "arg2_id": "DS.d1175.s0.e0", "normalized": [] } ]
DS.d1176
18793216
[ { "id": "DS.d1176.s0", "type": "", "text": [ "In vivo administration of a synthetic phospholipid, named hereafter phospho-ceramide analogue-1 (PCERA-1), was previously found to suppress lipopolysaccharide (LPS)-induced TNF-alpha blood levels." ], "offsets": [ [ 0, 196 ] ] }, { "id": "DS.d1176.s1", "type": "", "text": [ "In conclusion, the anti-inflammatory activity of PCERA-1 seems to be mediated by a cell membrane receptor, upstream of cAMP production, and eventually TNF-alpha suppression and IL-10 induction." ], "offsets": [ [ 197, 390 ] ] } ]
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"P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d1176.s1.e0", "type": "compound", "text": [ "cAMP" ], "offsets": [ [ 316, 320 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6076" } ] }, { "id": "DS.d1176.s1.e1", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 348, 357 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d1176.s1.e2", "type": "protein", "text": [ "IL-10" ], "offsets": [ [ 374, 379 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46673" }, { "db_name": "UniProt", "db_id": "O97798" }, { "db_name": "UniProt", "db_id": "P18893" }, { "db_name": "UniProt", "db_id": "P22301" }, { "db_name": "UniProt", "db_id": "P29456" }, { "db_name": "UniProt", "db_id": "P43480" }, { "db_name": "UniProt", "db_id": "P46651" }, { "db_name": "UniProt", "db_id": "P47965" }, { "db_name": "UniProt", "db_id": "P48411" }, { "db_name": "UniProt", "db_id": "P51496" }, { "db_name": "UniProt", "db_id": "P51497" }, { "db_name": "UniProt", "db_id": "P51746" }, { "db_name": "UniProt", "db_id": "P55029" }, { "db_name": "UniProt", "db_id": "P79338" }, { "db_name": "UniProt", "db_id": "Q0Z972" }, { "db_name": "UniProt", "db_id": "Q25BC1" }, { "db_name": "UniProt", "db_id": "Q28374" }, { "db_name": "UniProt", "db_id": "Q29055" }, { "db_name": "UniProt", "db_id": "Q29408" }, { "db_name": "UniProt", "db_id": "Q2PE73" }, { "db_name": "UniProt", "db_id": "Q5Q0V6" }, { "db_name": "UniProt", "db_id": "Q865X4" }, { "db_name": "UniProt", "db_id": "Q8MKG9" }, { "db_name": "UniProt", "db_id": "Q9JHK7" }, { "db_name": "UniProt", "db_id": "Q9TSJ4" }, { "db_name": "UniProt", "db_id": "Q9Z1Y5" } ] } ]
[]
[]
[ { "id": "DS.d1176.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1176.s0.e0", "arg2_id": "DS.d1176.s0.e1", "normalized": [] } ]
DS.d1177
18793341
[ { "id": "DS.d1177.s0", "type": "", "text": [ "Acylated ghrelin and TNF α, IFN γ, IL-1β and IL-6 were measured with bioplex." ], "offsets": [ [ 0, 77 ] ] } ]
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[]
[]
[]
DS.d1178
18793347
[ { "id": "DS.d1178.s0", "type": "", "text": [ "Pre-gravid physical activity and reduced risk of glucose intolerance in pregnancy : the role of insulin sensitivity." ], "offsets": [ [ 0, 116 ] ] }, { "id": "DS.d1178.s1", "type": "", "text": [ "Thus, we sought to study the relationships between types of pre-gravid physical activity and metabolic parameters in pregnancy, including glucose tolerance, insulin sensitivity and beta-cell function." ], "offsets": [ [ 117, 317 ] ] } ]
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[]
[]
[ { "id": "DS.d1178.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1178.s0.e0", "arg2_id": "DS.d1178.s0.e1", "normalized": [] } ]
DS.d1179
18793351
[ { "id": "DS.d1179.s0", "type": "", "text": [ "Inhibition of autophagy by treating rats with Wortmannin (15 microg/kg; intraperitoneally) abolished the ischaemic adaptation-induced induction of LC3-II, Beclin-1, BAG-1 and cardioprotection." ], "offsets": [ [ 0, 192 ] ] } ]
[ { "id": "DS.d1179.s0.e0", "type": "compound", "text": [ "Wortmannin" ], "offsets": [ [ 46, 56 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "312145" } ] }, { "id": "DS.d1179.s0.e1", "type": "protein", "text": [ "LC3" ], "offsets": [ [ 147, 150 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P82160" } ] }, { "id": "DS.d1179.s0.e2", "type": "protein", "text": [ "Beclin-1" ], "offsets": [ [ 155, 163 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O88597" }, { "db_name": "UniProt", "db_id": "Q14457" }, { "db_name": "UniProt", "db_id": "Q4A1L4" }, { "db_name": "UniProt", "db_id": "Q4A1L5" } ] }, { "id": "DS.d1179.s0.e3", "type": "protein", "text": [ "BAG-1" ], "offsets": [ [ 165, 170 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q60739" }, { "db_name": "UniProt", "db_id": "Q99933" } ] } ]
[]
[]
[ { "id": "DS.d1179.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1179.s0.e0", "arg2_id": "DS.d1179.s0.e1", "normalized": [] }, { "id": "DS.d1179.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1179.s0.e0", "arg2_id": "DS.d1179.s0.e3", "normalized": [] }, { "id": "DS.d1179.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1179.s0.e0", "arg2_id": "DS.d1179.s0.e2", "normalized": [] } ]
DS.d1181
18793694
[ { "id": "DS.d1181.s0", "type": "", "text": [ "When myosin molecules work as an aggregate, the sliding movement of a myosin filament driven by the power strokes of some myosin heads makes other myosin heads that have completed their power strokes detach from the actin without consuming ATP." ], "offsets": [ [ 0, 244 ] ] }, { "id": "DS.d1181.s1", "type": "", "text": [ "A critical requirement for this mechanism is that ATP must preferentially facilitate the detachment of myosins that have completed their power strokes, but are still strongly attached to the actin." ], "offsets": [ [ 245, 442 ] ] } ]
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"db_name": "UniProt", "db_id": "Q9UVZ8" } ] } ]
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[]
[]
DS.d1183
18794178
[ { "id": "DS.d1183.s0", "type": "", "text": [ "Efficacy, safety and patient-reported outcomes of combination etanercept and sulfasalazine versus etanercept alone in patients with rheumatoid arthritis: a double-blind randomised 2-year study." ], "offsets": [ [ 0, 193 ] ] }, { "id": "DS.d1183.s1", "type": "", "text": [ "To determine the efficacy and safety of etanercept and etanercept plus sulfasalazine versus sulfasalazine in patients with rheumatoid arthritis (RA) despite sulfasalazine therapy." ], "offsets": [ [ 194, 373 ] ] } ]
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[]
[]
[]
DS.d1184
18794865
[ { "id": "DS.d1184.s0", "type": "", "text": [ "A randomized trial of etoposide and G-CSF with or without rituximab for PBSC mobilization in B-cell non-Hodgkin's lymphoma." ], "offsets": [ [ 0, 123 ] ] }, { "id": "DS.d1184.s1", "type": "", "text": [ "Twenty seven patients were mobilized with etoposide and G-CSF and 28 with etoposide, G-CSF and rituximab." ], "offsets": [ [ 124, 229 ] ] } ]
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[]
[]
[]
DS.d1185
18795231
[ { "id": "DS.d1185.s0", "type": "", "text": [ "Aberrant methylation of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene is a predictive marker for the response to chemotherapy with alkylating agents (e.g., temozolomide) in malignant gliomas." ], "offsets": [ [ 0, 211 ] ] } ]
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[]
[]
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DS.d1186
18795240
[ { "id": "DS.d1186.s0", "type": "", "text": [ "This work describes the influence of two polar lipids, Sn-1/3 and Sn-2 monopalmitin, on the activity of lipase in biphasic systems and in microemulsions." ], "offsets": [ [ 0, 153 ] ] }, { "id": "DS.d1186.s1", "type": "", "text": [ "In previous communications, we have shown that Sn-2 monoglycerides can replace Sn-1,3 regiospecific lipases at the oil-water interface, causing a drastically reduced rate of lipolysis." ], "offsets": [ [ 154, 338 ] ] } ]
[ { "id": "DS.d1186.s0.e0", "type": "compound", "text": [ "2 monopalmitin" ], "offsets": [ [ 69, 83 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "123409" } ] }, { "id": "DS.d1186.s0.e1", "type": "protein", "text": [ "lipase" ], "offsets": [ [ 104, 110 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q7M4U7" } ] }, { "id": "DS.d1186.s1.e0", "type": "compound", "text": [ "2 monoglycerides" ], "offsets": [ [ 204, 220 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "17756737" } ] }, { "id": "DS.d1186.s1.e1", "type": "protein", "text": [ "lipases" ], "offsets": [ [ 254, 261 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q7M4U7" } ] } ]
[]
[]
[ { "id": "DS.d1186.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1186.s0.e0", "arg2_id": "DS.d1186.s0.e1", "normalized": [] }, { "id": "DS.d1186.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1186.s1.e0", "arg2_id": "DS.d1186.s1.e1", "normalized": [] } ]
DS.d1187
18795263
[ { "id": "DS.d1187.s0", "type": "", "text": [ "Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions." ], "offsets": [ [ 0, 373 ] ] }, { "id": "DS.d1187.s1", "type": "", "text": [ "Our results suggest a more prominent role for H2 as electron carrier in the syntrophic conversion of propionate, when the essential trace metals W and Mo for the functioning of formate dehydrogenase are depleted." ], "offsets": [ [ 374, 586 ] ] } ]
[ { "id": "DS.d1187.s0.e0", "type": "compound", "text": [ "propionate" ], "offsets": [ [ 118, 128 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1032" } ] }, { "id": "DS.d1187.s0.e1", "type": "compound", "text": [ "fumarate" ], "offsets": [ [ 134, 142 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444972" } ] }, { "id": "DS.d1187.s0.e2", "type": "protein", "text": [ "hydrogenase" ], "offsets": [ [ 194, 205 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P80509" }, { "db_name": "UniProt", "db_id": "P80510" } ] }, { "id": "DS.d1187.s0.e3", "type": "protein", "text": [ "formate dehydrogenase" ], "offsets": [ [ 221, 242 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P33160" }, { "db_name": "UniProt", "db_id": "P33677" }, { "db_name": "UniProt", "db_id": "Q07103" } ] }, { "id": "DS.d1187.s1.e0", "type": "compound", "text": [ "propionate" ], "offsets": [ [ 475, 485 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1032" } ] }, { "id": "DS.d1187.s1.e1", "type": "protein", "text": [ "formate dehydrogenase" ], "offsets": [ [ 551, 572 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P33160" }, { "db_name": "UniProt", "db_id": "P33677" }, { "db_name": "UniProt", "db_id": "Q07103" } ] } ]
[]
[]
[ { "id": "DS.d1187.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1187.s1.e0", "arg2_id": "DS.d1187.s1.e1", "normalized": [] } ]
DS.d1188
18795264
[ { "id": "DS.d1188.s0", "type": "", "text": [ "Previous studies have demonstrated an association between genetic polymorphisms of the mu opioid receptor gene (OPRM1) and response to naltrexone treatment." ], "offsets": [ [ 0, 156 ] ] } ]
[ { "id": "DS.d1188.s0.e0", "type": "protein", "text": [ "OPRM1" ], "offsets": [ [ 112, 117 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P35372" }, { "db_name": "UniProt", "db_id": "P79350" }, { "db_name": "UniProt", "db_id": "P97266" }, { "db_name": "UniProt", "db_id": "Q5IS39" }, { "db_name": "UniProt", "db_id": "Q5IS84" }, { "db_name": "UniProt", "db_id": "Q95247" }, { "db_name": "UniProt", "db_id": "Q95M54" }, { "db_name": "UniProt", "db_id": "Q9MYW9" } ] }, { "id": "DS.d1188.s0.e1", "type": "compound", "text": [ "naltrexone" ], "offsets": [ [ 135, 145 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5360515" } ] } ]
[]
[]
[ { "id": "DS.d1188.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1188.s0.e1", "arg2_id": "DS.d1188.s0.e0", "normalized": [] } ]
DS.d1189
18795290
[ { "id": "DS.d1189.s0", "type": "", "text": [ "Based on the preclinical evidence of topoisomerase I (Topo-1) upregulation by mitomycin C (MMC) and decreased NF-kappaB activation by celecoxib, we evaluated combinations of irinotecan/MMC and irinotecan/MMC/celecoxib in patients with advanced solid malignancies." ], "offsets": [ [ 0, 263 ] ] } ]
[ { "id": "DS.d1189.s0.e0", "type": "protein", "text": [ "topoisomerase" ], "offsets": [ [ 37, 50 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O29238" }, { "db_name": "UniProt", "db_id": "O51934" }, { "db_name": "UniProt", "db_id": "O58530" }, { "db_name": "UniProt", "db_id": "O67037" }, { "db_name": "UniProt", "db_id": "O67226" }, { "db_name": "UniProt", "db_id": "P74759" }, { "db_name": "UniProt", "db_id": "P95479" }, { "db_name": "UniProt", "db_id": "Q08582" }, { "db_name": "UniProt", "db_id": "Q58907" }, { "db_name": "UniProt", "db_id": "Q6F598" }, { "db_name": "UniProt", "db_id": "Q8R979" }, { "db_name": "UniProt", "db_id": "Q8ZXT5" }, { "db_name": "UniProt", "db_id": "Q971T7" }, { "db_name": "UniProt", "db_id": "Q975P6" }, { "db_name": "UniProt", "db_id": "Q97ZF5" }, { "db_name": "UniProt", "db_id": "Q97ZZ8" }, { "db_name": "UniProt", "db_id": "Q9UZ86" }, { "db_name": "UniProt", "db_id": "Q9YC75" }, { "db_name": "UniProt", "db_id": "Q9YCB6" } ] }, { "id": "DS.d1189.s0.e1", "type": "compound", "text": [ "mitomycin C" ], "offsets": [ [ 78, 89 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5746" } ] } ]
[]
[]
[ { "id": "DS.d1189.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1189.s0.e1", "arg2_id": "DS.d1189.s0.e0", "normalized": [] } ]
DS.d1190
18795320
[ { "id": "DS.d1190.s0", "type": "", "text": [ "The cells expressed aquaporin-1 sensitive to HgCl (2) and decreased by siRNA, which both reduced fast volume changes." ], "offsets": [ [ 0, 117 ] ] } ]
[ { "id": "DS.d1190.s0.e0", "type": "protein", "text": [ "aquaporin-1" ], "offsets": [ [ 20, 31 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29972" }, { "db_name": "UniProt", "db_id": "P29975" }, { "db_name": "UniProt", "db_id": "P47865" }, { "db_name": "UniProt", "db_id": "P53386" }, { "db_name": "UniProt", "db_id": "P56401" }, { "db_name": "UniProt", "db_id": "P61837" }, { "db_name": "UniProt", "db_id": "P61838" }, { "db_name": "UniProt", "db_id": "Q02013" }, { "db_name": "UniProt", "db_id": "Q5R819" }, { "db_name": "UniProt", "db_id": "Q6PQZ1" }, { "db_name": "UniProt", "db_id": "Q9N2J4" } ] }, { "id": "DS.d1190.s0.e1", "type": "compound", "text": [ "HgCl" ], "offsets": [ [ 45, 49 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24182" } ] } ]
[]
[]
[ { "id": "DS.d1190.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1190.s0.e1", "arg2_id": "DS.d1190.s0.e0", "normalized": [] } ]
DS.d1191
18795889
[ { "id": "DS.d1191.s0", "type": "", "text": [ "Two conserved leucine repeats within the COMM domain were found to be critically required for XIAP binding." ], "offsets": [ [ 0, 107 ] ] } ]
[ { "id": "DS.d1191.s0.e0", "type": "compound", "text": [ "leucine" ], "offsets": [ [ 14, 21 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "857" }, { "db_name": "PubChem", "db_id": "6106" }, { "db_name": "PubChem", "db_id": "439524" } ] }, { "id": "DS.d1191.s0.e1", "type": "protein", "text": [ "XIAP" ], "offsets": [ [ 94, 98 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P98170" } ] } ]
[]
[]
[ { "id": "DS.d1191.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1191.s0.e0", "arg2_id": "DS.d1191.s0.e1", "normalized": [] } ]
DS.d1192
18795892
[ { "id": "DS.d1192.s0", "type": "", "text": [ "Functional analysis of rat liver citrate carrier promoter: differential responsiveness to polyunsaturated fatty acids." ], "offsets": [ [ 0, 118 ] ] } ]
[ { "id": "DS.d1192.s0.e0", "type": "protein", "text": [ "citrate carrier" ], "offsets": [ [ 33, 48 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0AE74" }, { "db_name": "UniProt", "db_id": "P0AE75" } ] }, { "id": "DS.d1192.s0.e1", "type": "compound", "text": [ "polyunsaturated fatty acids" ], "offsets": [ [ 90, 117 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "56842239" } ] } ]
[]
[]
[ { "id": "DS.d1192.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1192.s0.e1", "arg2_id": "DS.d1192.s0.e0", "normalized": [] } ]
DS.d1193
18795918
[ { "id": "DS.d1193.s0", "type": "", "text": [ "Wet-wrap treatment using dilutions of tacrolimus ointment and fluticasone propionate cream in human APOC1 (+/+) mice with atopic dermatitis." ], "offsets": [ [ 0, 140 ] ] } ]
[ { "id": "DS.d1193.s0.e0", "type": "compound", "text": [ "tacrolimus" ], "offsets": [ [ 38, 48 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5372" }, { "db_name": "PubChem", "db_id": "445643" }, { "db_name": "PubChem", "db_id": "445647" }, { "db_name": "PubChem", "db_id": "6426916" }, { "db_name": "PubChem", "db_id": "6436007" }, { "db_name": "PubChem", "db_id": "6473866" }, { "db_name": "PubChem", "db_id": "6536850" }, { "db_name": "PubChem", "db_id": "9940643" }, { "db_name": "PubChem", "db_id": "23581796" }, { "db_name": "PubChem", "db_id": "54611630" } ] }, { "id": "DS.d1193.s0.e1", "type": "compound", "text": [ "fluticasone propionate" ], "offsets": [ [ 62, 84 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444036" } ] }, { "id": "DS.d1193.s0.e2", "type": "protein", "text": [ "APOC1" ], "offsets": [ [ 100, 105 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02654" }, { "db_name": "UniProt", "db_id": "P18657" }, { "db_name": "UniProt", "db_id": "P33047" }, { "db_name": "UniProt", "db_id": "P34929" }, { "db_name": "UniProt", "db_id": "P56595" }, { "db_name": "UniProt", "db_id": "Q9XSN5" } ] } ]
[]
[]
[]
DS.d1194
18795969
[ { "id": "DS.d1194.s0", "type": "", "text": [ "The use of low-dose COCs is preferable in PCOS, especially among patients with glucose intolerance, insulin resistance and uncomplicated diabetes mellitus." ], "offsets": [ [ 0, 155 ] ] } ]
[ { "id": "DS.d1194.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 79, 86 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1194.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 100, 107 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
[]
DS.d1195
18796314
[ { "id": "DS.d1195.s0", "type": "", "text": [ "Due to its faculty to protect cholinesterase (ChE) activity against irreversible inactivation by OP, pyridostigmine bromide (PB) was used as a prophylaxis treatment during the first Persian Gulf War." ], "offsets": [ [ 0, 199 ] ] } ]
[ { "id": "DS.d1195.s0.e0", "type": "protein", "text": [ "cholinesterase" ], "offsets": [ [ 30, 44 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P32749" }, { "db_name": "UniProt", "db_id": "P32750" }, { "db_name": "UniProt", "db_id": "P32751" }, { "db_name": "UniProt", "db_id": "P32752" }, { "db_name": "UniProt", "db_id": "P32753" }, { "db_name": "UniProt", "db_id": "P81908" } ] }, { "id": "DS.d1195.s0.e1", "type": "compound", "text": [ "pyridostigmine bromide" ], "offsets": [ [ 101, 123 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4991" } ] } ]
[]
[]
[ { "id": "DS.d1195.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1195.s0.e1", "arg2_id": "DS.d1195.s0.e0", "normalized": [] } ]
DS.d1196
18796403
[ { "id": "DS.d1196.s0", "type": "", "text": [ "Mice lacking Niemann-Pick C1-Like 1 (NPC1L1) (NPC1L1 (-/-)mice) exhibit a defect in intestinal absorption of cholesterol and phytosterols." ], "offsets": [ [ 0, 138 ] ] }, { "id": "DS.d1196.s1", "type": "", "text": [ "In this study, we examined the role of NPC1L1 in phytosterol and cholesterol trafficking in mice lacking ATP-binding cassette (ABC) transporters G5 and G8 (G5/G8(-/-) mice)." ], "offsets": [ [ 139, 312 ] ] }, { "id": "DS.d1196.s2", "type": "", "text": [ "We found that mice lacking ABCG5/G8 and NPC1L1 (triple knockout (TKO) mice) did not accumulate phytosterols in plasma and the liver." ], "offsets": [ [ 313, 445 ] ] }, { "id": "DS.d1196.s3", "type": "", "text": [ "In conclusion, NPC1L1 is essential for phytosterols to enter the body in mice." ], "offsets": [ [ 446, 524 ] ] } ]
[ { "id": "DS.d1196.s0.e0", "type": "protein", "text": [ "NPC1L1" ], "offsets": [ [ 37, 43 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UHC9" } ] }, { "id": "DS.d1196.s0.e1", "type": "protein", "text": [ "NPC1L1" ], "offsets": [ [ 46, 52 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UHC9" } ] }, { "id": "DS.d1196.s0.e2", "type": "compound", "text": [ "phytosterols" ], "offsets": [ [ 125, 137 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "12303662" } ] }, { "id": "DS.d1196.s1.e0", "type": "protein", "text": [ "NPC1L1" ], "offsets": [ [ 178, 184 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UHC9" } ] }, { "id": "DS.d1196.s1.e1", "type": "compound", "text": [ "phytosterol" ], "offsets": [ [ 188, 199 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "222284" }, { "db_name": "PubChem", "db_id": "457801" } ] }, { "id": "DS.d1196.s2.e0", "type": "protein", "text": [ "ABCG5" ], "offsets": [ [ 340, 345 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9H222" } ] }, { "id": "DS.d1196.s2.e1", "type": "protein", "text": [ "NPC1L1" ], "offsets": [ [ 353, 359 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UHC9" } ] }, { "id": "DS.d1196.s2.e2", "type": "compound", "text": [ "phytosterols" ], "offsets": [ [ 408, 420 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "12303662" } ] }, { "id": "DS.d1196.s3.e0", "type": "protein", "text": [ "NPC1L1" ], "offsets": [ [ 461, 467 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UHC9" } ] }, { "id": "DS.d1196.s3.e1", "type": "compound", "text": [ "phytosterols" ], "offsets": [ [ 485, 497 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "12303662" } ] } ]
[]
[]
[ { "id": "DS.d1196.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1196.s0.e2", "arg2_id": "DS.d1196.s0.e0", "normalized": [] }, { "id": "DS.d1196.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1196.s3.e1", "arg2_id": "DS.d1196.s3.e0", "normalized": [] } ]
DS.d1197
18796561
[ { "id": "DS.d1197.s0", "type": "", "text": [ "The slow BSO-induced GSH depletion allows separation of two redox-related phases, namely, early thiol disequilibrium and late frank oxidative stress; each phase contributes to the progressive activation of a p50-p50 homodimer." ], "offsets": [ [ 0, 226 ] ] } ]
[ { "id": "DS.d1197.s0.e0", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 21, 24 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d1197.s0.e1", "type": "protein", "text": [ "p50" ], "offsets": [ [ 208, 211 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P23061" }, { "db_name": "UniProt", "db_id": "P38644" }, { "db_name": "UniProt", "db_id": "P83939" }, { "db_name": "UniProt", "db_id": "Q05894" }, { "db_name": "UniProt", "db_id": "Q28618" }, { "db_name": "UniProt", "db_id": "Q43731" } ] }, { "id": "DS.d1197.s0.e2", "type": "protein", "text": [ "p50" ], "offsets": [ [ 212, 215 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P23061" }, { "db_name": "UniProt", "db_id": "P38644" }, { "db_name": "UniProt", "db_id": "P83939" }, { "db_name": "UniProt", "db_id": "Q05894" }, { "db_name": "UniProt", "db_id": "Q28618" }, { "db_name": "UniProt", "db_id": "Q43731" } ] } ]
[]
[]
[]
DS.d1198
18796623
[ { "id": "DS.d1198.s0", "type": "", "text": [ "In contrast, Notch-signaling inhibition by the gamma-secretase inhibitor I (GSI ; z-Leu-Leu-Nle-CHO) and the specific Notch2 down-regulation by small-interfering RNA accelerate spontaneous B-CLL cell apoptosis." ], "offsets": [ [ 0, 210 ] ] } ]
[ { "id": "DS.d1198.s0.e0", "type": "compound", "text": [ "gamma-secretase inhibitor I" ], "offsets": [ [ 47, 74 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16760646" } ] }, { "id": "DS.d1198.s0.e1", "type": "protein", "text": [ "Notch2" ], "offsets": [ [ 118, 124 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35516" }, { "db_name": "UniProt", "db_id": "Q9QW30" } ] } ]
[]
[]
[]
DS.d1199
18797825
[ { "id": "DS.d1199.s0", "type": "", "text": [ "Effects of exhaustion and calcium supplementation on adrenocorticotropic hormone and cortisol levels in athletes." ], "offsets": [ [ 0, 113 ] ] }, { "id": "DS.d1199.s1", "type": "", "text": [ "The present study was performed to investigate the effects of strenuous exercise and calcium supplementation on cortisol and adrenocorticotropic hormone levels in athletes at rest and exhaustion." ], "offsets": [ [ 114, 309 ] ] }, { "id": "DS.d1199.s2", "type": "", "text": [ "One-month supplementation with calcium does not influence the cortisol and adrenocorticotropic hormone 0.05)." ], "offsets": [ [ 310, 419 ] ] } ]
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[]
[]
[]
DS.d1200
18797870
[ { "id": "DS.d1200.s0", "type": "", "text": [ "Effects of nonspecific targeting of FLT3 were evaluated with addition of imatinib (Gleevec) to cell cultures." ], "offsets": [ [ 0, 109 ] ] } ]
[ { "id": "DS.d1200.s0.e0", "type": "protein", "text": [ "FLT3" ], "offsets": [ [ 36, 40 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P36888" } ] }, { "id": "DS.d1200.s0.e1", "type": "compound", "text": [ "Gleevec" ], "offsets": [ [ 83, 90 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5291" } ] } ]
[]
[]
[]
DS.d1201
18797914
[ { "id": "DS.d1201.s0", "type": "", "text": [ "In the pericentral necrotic zone after CCl4-treatment, no induction of Thy-1 was found." ], "offsets": [ [ 0, 87 ] ] } ]
[ { "id": "DS.d1201.s0.e0", "type": "compound", "text": [ "CCl4" ], "offsets": [ [ 39, 43 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5943" } ] }, { "id": "DS.d1201.s0.e1", "type": "protein", "text": [ "Thy-1" ], "offsets": [ [ 71, 76 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01830" }, { "db_name": "UniProt", "db_id": "P01831" } ] } ]
[]
[]
[]
DS.d1202
18797943
[ { "id": "DS.d1202.s0", "type": "", "text": [ "Sixty-one percent of the isolates were beta-lactamase producers, which explains the poor activity of penicillin." ], "offsets": [ [ 0, 112 ] ] } ]
[ { "id": "DS.d1202.s0.e0", "type": "protein", "text": [ "beta-lactamase" ], "offsets": [ [ 39, 53 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P80298" }, { "db_name": "UniProt", "db_id": "P80545" }, { "db_name": "UniProt", "db_id": "P81173" } ] }, { "id": "DS.d1202.s0.e1", "type": "compound", "text": [ "penicillin" ], "offsets": [ [ 101, 111 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5904" } ] } ]
[]
[]
[ { "id": "DS.d1202.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1202.s0.e1", "arg2_id": "DS.d1202.s0.e0", "normalized": [] } ]
DS.d1204
18798281
[ { "id": "DS.d1204.s0", "type": "", "text": [ "In contrast, chelating intracellular calcium ((Ca(2+))(i)) by BAPTA-AM abolished BDNF-mediated Arc up-regulation." ], "offsets": [ [ 0, 113 ] ] }, { "id": "DS.d1204.s1", "type": "", "text": [ "These data suggested novel functions of (Ca(2+))(i) and CaM in BDNF signaling." ], "offsets": [ [ 114, 192 ] ] }, { "id": "DS.d1204.s2", "type": "", "text": [ "Comparison of the Arc transcription profiles between Ca(2+)-stimulated and BDNF-stimulated neurons demonstrated that the regulatory mechanisms were distinctively tailored to the complex features of neuronal activity." ], "offsets": [ [ 193, 409 ] ] } ]
[ { "id": "DS.d1204.s0.e0", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 47, 51 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d1204.s0.e1", "type": "compound", "text": [ "BAPTA-AM" ], "offsets": [ [ 62, 70 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2293" } ] }, { "id": "DS.d1204.s0.e2", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 81, 85 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] }, { "id": "DS.d1204.s1.e0", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 155, 159 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d1204.s1.e1", "type": "protein", "text": [ "CaM" ], "offsets": [ [ 170, 173 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02367" }, { "db_name": "UniProt", "db_id": "O16305" }, { "db_name": "UniProt", "db_id": "O60041" }, { "db_name": "UniProt", "db_id": "O82018" }, { "db_name": "UniProt", "db_id": "O94739" }, { "db_name": "UniProt", "db_id": "O96102" 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"db_name": "UniProt", "db_id": "P27161" }, { "db_name": "UniProt", "db_id": "P27165" }, { "db_name": "UniProt", "db_id": "P27166" }, { "db_name": "UniProt", "db_id": "P41040" }, { "db_name": "UniProt", "db_id": "P41041" }, { "db_name": "UniProt", "db_id": "P48976" }, { "db_name": "UniProt", "db_id": "P60204" }, { "db_name": "UniProt", "db_id": "P60205" }, { "db_name": "UniProt", "db_id": "P60206" }, { "db_name": "UniProt", "db_id": "P61859" }, { "db_name": "UniProt", "db_id": "P61860" }, { "db_name": "UniProt", "db_id": "P61861" }, { "db_name": "UniProt", "db_id": "P62144" }, { "db_name": "UniProt", "db_id": "P62145" }, { "db_name": "UniProt", "db_id": "P62149" }, { "db_name": "UniProt", "db_id": "P62151" }, { "db_name": "UniProt", "db_id": "P62152" }, { "db_name": "UniProt", "db_id": "P62154" }, { "db_name": "UniProt", "db_id": "P62155" }, { "db_name": "UniProt", "db_id": "P62156" }, { "db_name": "UniProt", "db_id": "P62157" }, { "db_name": "UniProt", "db_id": "P62158" }, { "db_name": "UniProt", "db_id": "P62160" }, { "db_name": "UniProt", "db_id": "P62161" }, { "db_name": "UniProt", "db_id": "P62162" }, { "db_name": "UniProt", "db_id": "P62184" }, { "db_name": "UniProt", "db_id": "P62201" }, { "db_name": "UniProt", "db_id": "P62202" }, { "db_name": "UniProt", "db_id": "P62203" }, { "db_name": "UniProt", "db_id": "P62204" }, { "db_name": "UniProt", "db_id": "P69097" }, { "db_name": "UniProt", "db_id": "P69098" }, { "db_name": "UniProt", "db_id": "P84339" }, { "db_name": "UniProt", "db_id": "P93087" }, { "db_name": "UniProt", "db_id": "P93171" }, { "db_name": "UniProt", "db_id": "Q00168" }, { "db_name": "UniProt", "db_id": "Q05055" }, { "db_name": "UniProt", "db_id": "Q39752" }, { "db_name": "UniProt", "db_id": "Q40302" }, { "db_name": "UniProt", "db_id": "Q5EHV7" }, { "db_name": "UniProt", "db_id": "Q5RAD2" }, { "db_name": "UniProt", "db_id": "Q6IT78" }, { "db_name": "UniProt", "db_id": "Q6PI52" }, { "db_name": "UniProt", "db_id": "Q6R520" }, { "db_name": "UniProt", "db_id": "Q6YNX6" }, { "db_name": "UniProt", "db_id": "Q71UH5" }, { "db_name": "UniProt", "db_id": "Q71UH6" }, { "db_name": "UniProt", "db_id": "Q7T3T2" }, { "db_name": "UniProt", "db_id": "Q7Y052" }, { "db_name": "UniProt", "db_id": "Q8STF0" }, { "db_name": "UniProt", "db_id": "Q8X187" }, { "db_name": "UniProt", "db_id": "Q95NI4" }, { "db_name": "UniProt", "db_id": "Q95NR9" }, { "db_name": "UniProt", "db_id": "Q9GRJ1" }, { "db_name": "UniProt", "db_id": "Q9HFY6" }, { "db_name": "UniProt", "db_id": "Q9U6D3" }, { "db_name": "UniProt", "db_id": "Q9UWF0" } ] }, { "id": "DS.d1204.s1.e2", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 177, 181 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] }, { "id": "DS.d1204.s2.e0", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 246, 250 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d1204.s2.e1", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 268, 272 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] } ]
[]
[]
[ { "id": "DS.d1204.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1204.s1.e0", "arg2_id": "DS.d1204.s1.e2", "normalized": [] } ]
DS.d1205
18798567
[ { "id": "DS.d1205.s0", "type": "", "text": [ "Bark of elderberry (Sambucus nigra) contains a galactose (Gal)/N-acetylgalactosamine (GalNAc)-specific lectin (SNA-II) corresponding to slightly truncated B-chains of a genuine Type-II ribosome-inactivating protein (Type-II RIPs, SNA-V), found in the same species." ], "offsets": [ [ 0, 264 ] ] } ]
[ { "id": "DS.d1205.s0.e0", "type": "compound", "text": [ "GalNAc" ], "offsets": [ [ 86, 92 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "35717" }, { "db_name": "PubChem", "db_id": "84265" } ] }, { "id": "DS.d1205.s0.e1", "type": "protein", "text": [ "lectin" ], "offsets": [ [ 103, 109 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02871" }, { "db_name": "UniProt", "db_id": "P02873" }, { "db_name": "UniProt", "db_id": "P02874" }, { "db_name": "UniProt", "db_id": "P02875" }, { "db_name": "UniProt", "db_id": "P07386" }, { "db_name": "UniProt", "db_id": "P16108" }, { "db_name": "UniProt", "db_id": "P16349" }, { "db_name": "UniProt", "db_id": "P16351" }, { "db_name": "UniProt", "db_id": "P16352" }, { "db_name": "UniProt", "db_id": "P33888" }, { "db_name": "UniProt", "db_id": "P38662" }, { "db_name": "UniProt", "db_id": "P42088" }, { "db_name": "UniProt", "db_id": "P83410" }, { "db_name": "UniProt", "db_id": "P83511" }, { "db_name": "UniProt", "db_id": "P84987" }, { "db_name": "UniProt", "db_id": "Q41114" } ] }, { "id": "DS.d1205.s0.e2", "type": "protein", "text": [ "ribosome-inactivating protein" ], "offsets": [ [ 185, 214 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10297" }, { "db_name": "UniProt", "db_id": "P21326" }, { "db_name": "UniProt", "db_id": "P23339" }, { "db_name": "UniProt", "db_id": "P24475" }, { "db_name": "UniProt", "db_id": "P24476" }, { "db_name": "UniProt", "db_id": "P24477" }, { "db_name": "UniProt", "db_id": "P80750" }, { "db_name": "UniProt", "db_id": "Q03464" }, { "db_name": "UniProt", "db_id": "Q40772" } ] }, { "id": "DS.d1205.s0.e3", "type": "protein", "text": [ "RIPs" ], "offsets": [ [ 224, 228 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P24817" }, { "db_name": "UniProt", "db_id": "P52594" }, { "db_name": "UniProt", "db_id": "P56626" }, { "db_name": "UniProt", "db_id": "Q13546" }, { "db_name": "UniProt", "db_id": "Q2TA45" }, { "db_name": "UniProt", "db_id": "Q86UA6" } ] } ]
[]
[]
[ { "id": "DS.d1205.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1205.s0.e0", "arg2_id": "DS.d1205.s0.e1", "normalized": [] } ]
DS.d1206
18798730
[ { "id": "DS.d1206.s0", "type": "", "text": [ "Infusion of each receptor antagonist alone similarly reduced basal unstressed volume and blood flow in ACEI-treated CHF patients, but not in healthy volunteers or ARB-treated CHF patients." ], "offsets": [ [ 0, 188 ] ] }, { "id": "DS.d1206.s1", "type": "", "text": [ "In ARB-treated heart failure, venous responses to bradykinin are preserved but arterial responses are reduced compared with healthy controls." ], "offsets": [ [ 189, 330 ] ] } ]
[ { "id": "DS.d1206.s0.e0", "type": "protein", "text": [ "ACEI" ], "offsets": [ [ 103, 107 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9P8W3" } ] }, { "id": "DS.d1206.s0.e1", "type": "compound", "text": [ "ARB" ], "offsets": [ [ 163, 166 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439764" } ] }, { "id": "DS.d1206.s1.e0", "type": "compound", "text": [ "ARB" ], "offsets": [ [ 192, 195 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439764" } ] }, { "id": "DS.d1206.s1.e1", "type": "protein", "text": [ "bradykinin" ], "offsets": [ [ 239, 249 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08677" }, { "db_name": "UniProt", "db_id": "P01042" }, { "db_name": "UniProt", "db_id": "P01044" }, { "db_name": "UniProt", "db_id": "P01045" }, { "db_name": "UniProt", "db_id": "P08934" }, { "db_name": "UniProt", "db_id": "P83055" }, { "db_name": "UniProt", "db_id": "P83060" }, { "db_name": "UniProt", "db_id": "P83856" }, { "db_name": "UniProt", "db_id": "P83857" }, { "db_name": "UniProt", "db_id": "P84697" }, { "db_name": "UniProt", "db_id": "P84825" }, { "db_name": "UniProt", "db_id": "P84895" }, { "db_name": "UniProt", "db_id": "Q7T3L1" }, { "db_name": "UniProt", "db_id": "Q90W88" }, { "db_name": "UniProt", "db_id": "Q90WZ1" } ] } ]
[]
[]
[]
DS.d1207
18798833
[ { "id": "DS.d1207.s0", "type": "", "text": [ "Later-onset congenital central hypoventilation syndrome due to a heterozygous 24-polyalanine repeat expansion mutation in the PHOX2B gene." ], "offsets": [ [ 0, 138 ] ] }, { "id": "DS.d1207.s1", "type": "", "text": [ "to describe a family with later onset congenital central hypoventilation syndrome (LO-CCHS) and heterozygosity for a 24-polyalanine repeat expansion mutation in the PHOX2B gene, rendered phenotypically apparent with exposure to anesthetics." ], "offsets": [ [ 139, 379 ] ] } ]
[ { "id": "DS.d1207.s0.e0", "type": "compound", "text": [ "polyalanine" ], "offsets": [ [ 81, 92 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5950" } ] }, { "id": "DS.d1207.s0.e1", "type": "protein", "text": [ "PHOX2B" ], "offsets": [ [ 126, 132 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q99453" } ] }, { "id": "DS.d1207.s1.e0", "type": "compound", "text": [ "polyalanine" ], "offsets": [ [ 259, 270 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5950" } ] }, { "id": "DS.d1207.s1.e1", "type": "protein", "text": [ "PHOX2B" ], "offsets": [ [ 304, 310 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q99453" } ] } ]
[]
[]
[ { "id": "DS.d1207.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1207.s0.e0", "arg2_id": "DS.d1207.s0.e1", "normalized": [] }, { "id": "DS.d1207.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1207.s1.e0", "arg2_id": "DS.d1207.s1.e1", "normalized": [] } ]
DS.d1208
18798864
[ { "id": "DS.d1208.s0", "type": "", "text": [ "Effects of raloxifene on breast cancer cell migration and invasion through the actin cytoskeleton." ], "offsets": [ [ 0, 98 ] ] } ]
[ { "id": "DS.d1208.s0.e0", "type": "compound", "text": [ "raloxifene" ], "offsets": [ [ 11, 21 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5035" } ] }, { "id": "DS.d1208.s0.e1", "type": "protein", "text": [ "actin" ], "offsets": [ [ 79, 84 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00937" }, { "db_name": "UniProt", "db_id": "O13419" }, { "db_name": "UniProt", "db_id": "O16808" }, { "db_name": "UniProt", "db_id": "O17320" }, { "db_name": "UniProt", "db_id": "O65314" }, { "db_name": "UniProt", "db_id": "O65315" }, { "db_name": "UniProt", "db_id": "O65316" }, { "db_name": "UniProt", "db_id": "O74258" }, { "db_name": "UniProt", "db_id": "O81221" }, { "db_name": "UniProt", "db_id": "P02577" }, { "db_name": "UniProt", "db_id": "P10365" }, { "db_name": "UniProt", "db_id": "P10989" }, { "db_name": "UniProt", "db_id": "P11426" }, { "db_name": "UniProt", "db_id": "P13363" }, { "db_name": "UniProt", "db_id": "P14235" }, { "db_name": "UniProt", "db_id": "P17128" }, { "db_name": "UniProt", "db_id": "P20904" }, { "db_name": "UniProt", "db_id": "P24902" }, { "db_name": "UniProt", "db_id": "P26182" }, { "db_name": "UniProt", "db_id": "P26183" }, { "db_name": "UniProt", "db_id": "P30161" }, { "db_name": "UniProt", "db_id": "P45520" }, { "db_name": "UniProt", "db_id": "P45521" }, { "db_name": "UniProt", "db_id": "P48465" }, { "db_name": "UniProt", "db_id": "P50138" }, { "db_name": "UniProt", "db_id": "P51775" }, { "db_name": "UniProt", "db_id": "P53455" }, { "db_name": "UniProt", "db_id": "P53476" }, { "db_name": "UniProt", "db_id": "P53477" }, { "db_name": "UniProt", "db_id": "P53491" }, { "db_name": "UniProt", "db_id": "P53498" }, { "db_name": "UniProt", "db_id": "P53499" }, { "db_name": "UniProt", "db_id": "P53500" }, { "db_name": "UniProt", "db_id": "P53502" }, { "db_name": "UniProt", "db_id": "P53689" }, { "db_name": "UniProt", "db_id": "P60009" }, { "db_name": "UniProt", "db_id": "P60010" }, { "db_name": "UniProt", "db_id": "P60011" }, { "db_name": "UniProt", "db_id": "P68555" }, { "db_name": "UniProt", "db_id": "P78711" }, { "db_name": "UniProt", "db_id": "P80709" }, { "db_name": "UniProt", "db_id": "P81085" }, { "db_name": "UniProt", "db_id": "P90689" }, { "db_name": "UniProt", "db_id": "P91754" }, { "db_name": "UniProt", "db_id": "Q05214" }, { "db_name": "UniProt", "db_id": "Q11212" }, { "db_name": "UniProt", "db_id": "Q24733" }, { "db_name": "UniProt", "db_id": "Q2U7A3" }, { "db_name": "UniProt", "db_id": "Q39596" }, { "db_name": "UniProt", "db_id": "Q39758" }, { "db_name": "UniProt", "db_id": "Q6TCF2" }, { "db_name": "UniProt", "db_id": "Q75D00" }, { "db_name": "UniProt", "db_id": "Q8SWN8" }, { "db_name": "UniProt", "db_id": "Q8X119" }, { "db_name": "UniProt", "db_id": "Q92192" }, { "db_name": "UniProt", "db_id": "Q92193" }, { "db_name": "UniProt", "db_id": "Q99023" }, { "db_name": "UniProt", "db_id": "Q9P4D1" }, { "db_name": "UniProt", "db_id": "Q9UVF3" }, { "db_name": "UniProt", "db_id": "Q9UVX4" }, { "db_name": "UniProt", "db_id": "Q9UVZ8" } ] } ]
[]
[]
[ { "id": "DS.d1208.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1208.s0.e0", "arg2_id": "DS.d1208.s0.e1", "normalized": [] } ]
DS.d1209
18798867
[ { "id": "DS.d1209.s0", "type": "", "text": [ "High glucose attenuates VEGF expression in rat multipotent adult progenitor cells in association with inhibition of JAK2/STAT3 signalling." ], "offsets": [ [ 0, 138 ] ] }, { "id": "DS.d1209.s1", "type": "", "text": [ "This study was to investigate the effect of high glucose (HG) on vascular endothelial growth factor (VEGF) expression in bone marrow stem cells and JAK2/STAT-3 signalling." ], "offsets": [ [ 139, 310 ] ] } ]
[ { "id": "DS.d1209.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 5, 12 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1209.s0.e1", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 24, 28 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d1209.s0.e2", "type": "protein", "text": [ "JAK2" ], "offsets": [ [ 116, 120 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60674" } ] }, { "id": "DS.d1209.s0.e3", "type": "protein", "text": [ "STAT3" ], "offsets": [ [ 121, 126 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P40763" }, { "db_name": "UniProt", "db_id": "P61635" } ] }, { "id": "DS.d1209.s1.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 188, 195 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1209.s1.e1", "type": "compound", "text": [ "HG" ], "offsets": [ [ 197, 199 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23931" } ] }, { "id": "DS.d1209.s1.e2", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 240, 244 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d1209.s1.e3", "type": "protein", "text": [ "JAK2" ], "offsets": [ [ 287, 291 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60674" } ] }, { "id": "DS.d1209.s1.e4", "type": "protein", "text": [ "STAT" ], "offsets": [ [ 292, 296 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08457" }, { "db_name": "UniProt", "db_id": "P35610" }, { "db_name": "UniProt", "db_id": "Q7QDU4" } ] } ]
[]
[]
[ { "id": "DS.d1209.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1209.s0.e0", "arg2_id": "DS.d1209.s0.e1", "normalized": [] } ]
DS.d1211
18799187
[ { "id": "DS.d1211.s0", "type": "", "text": [ "Hepatic stellate cell activation in focal nodular hyperplasia with a central scar was accompanied by the expression of 8-hydroxy-2'-deoxyguanosine and inducible nitric oxide synthase in the liver." ], "offsets": [ [ 0, 196 ] ] }, { "id": "DS.d1211.s1", "type": "", "text": [ "Expression of 8-hydroxy-2'-deoxyguanosine and inducible nitric oxide synthase was rarely seen in focal nodular hyperplasia without a central scar, focal nodular hyperplasia-like nodules, or nodular regenerative hyperplasia." ], "offsets": [ [ 197, 420 ] ] } ]
[ { "id": "DS.d1211.s0.e0", "type": "compound", "text": [ "8-hydroxy-2'-deoxyguanosine" ], "offsets": [ [ 119, 146 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "73318" } ] }, { "id": "DS.d1211.s0.e1", "type": "protein", "text": [ "nitric oxide synthase" ], "offsets": [ [ 161, 182 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d1211.s1.e0", "type": "compound", "text": [ "8-hydroxy-2'-deoxyguanosine" ], "offsets": [ [ 211, 238 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "73318" } ] }, { "id": "DS.d1211.s1.e1", "type": "protein", "text": [ "nitric oxide synthase" ], "offsets": [ [ 253, 274 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] } ]
[]
[]
[]
DS.d1212
18799201
[ { "id": "DS.d1212.s0", "type": "", "text": [ "The main purpose of this study was to evaluate the regional distribution pattern and relative frequency of some endocrine cells in the three portions of the gastrointestinal tract (GIT)--the proventriculus, gizzard and duodenum-of the rufous-collared sparrow (Zonotrichia capensis subtorquata), by immunohistochemical methods using six types of polyclonal antisera, specific for serotonin (5-HT), somatostatin (D cells), glucagon, motilin, polypeptide YY (PYY) and insulin." ], "offsets": [ [ 0, 473 ] ] }, { "id": "DS.d1212.s1", "type": "", "text": [ "In the gizzard, endocrine cells secreting somatostatin, 5-HT and PYY were detected, while those secreting glucagon and insulin were not." ], "offsets": [ [ 474, 610 ] ] }, { "id": "DS.d1212.s2", "type": "", "text": [ "In the final part of the gizzard, endocrine cells secreting 5-HT were more frequent, and cells secreting somatostatin and insulin were not detected." ], "offsets": [ [ 611, 759 ] ] } ]
[ { "id": "DS.d1212.s0.e0", "type": "compound", "text": [ "serotonin" ], "offsets": [ [ 379, 388 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5202" } ] }, { "id": "DS.d1212.s0.e1", "type": "compound", "text": [ "5-HT" ], "offsets": [ [ 390, 394 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5202" } ] }, { "id": "DS.d1212.s0.e2", "type": "compound", "text": [ "somatostatin" ], "offsets": [ [ 397, 409 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16129681" }, { "db_name": "PubChem", "db_id": "16129706" } ] }, { "id": "DS.d1212.s0.e3", "type": "protein", "text": [ "glucagon" ], "offsets": [ [ 421, 429 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12956" }, { "db_name": "UniProt", "db_id": "O42143" }, { "db_name": "UniProt", "db_id": "O42144" }, { "db_name": "UniProt", "db_id": "P01272" }, { "db_name": "UniProt", "db_id": "P01273" }, { "db_name": "UniProt", "db_id": "P01274" }, { "db_name": "UniProt", "db_id": "P01275" }, { "db_name": "UniProt", "db_id": "P04093" }, { "db_name": "UniProt", "db_id": "P05110" }, { "db_name": "UniProt", "db_id": "P06883" }, { "db_name": "UniProt", "db_id": "P07449" }, { "db_name": "UniProt", "db_id": "P09566" }, { "db_name": "UniProt", "db_id": "P09567" }, { "db_name": "UniProt", "db_id": "P09682" }, { "db_name": "UniProt", "db_id": "P09686" }, { "db_name": "UniProt", "db_id": "P0C235" }, { "db_name": "UniProt", "db_id": "P13189" }, { "db_name": "UniProt", "db_id": "P15438" }, { "db_name": "UniProt", "db_id": "P18108" }, { "db_name": "UniProt", "db_id": "P22890" }, { "db_name": "UniProt", "db_id": "P29794" }, { "db_name": "UniProt", "db_id": "P31297" }, { "db_name": "UniProt", "db_id": "P33528" }, { "db_name": "UniProt", "db_id": "P55095" }, { "db_name": "UniProt", "db_id": "P68259" }, { "db_name": "UniProt", "db_id": "P68260" }, { "db_name": "UniProt", "db_id": "P68273" }, { "db_name": "UniProt", "db_id": "P68274" }, { "db_name": "UniProt", "db_id": "P68275" }, { "db_name": "UniProt", "db_id": "P68952" }, { "db_name": "UniProt", "db_id": "P68953" }, { "db_name": "UniProt", "db_id": "P68954" }, { "db_name": "UniProt", "db_id": "P68955" }, { "db_name": "UniProt", "db_id": "P68956" }, { "db_name": "UniProt", "db_id": "P68957" }, { "db_name": "UniProt", "db_id": "P79695" }, { "db_name": "UniProt", "db_id": "P81880" }, { "db_name": "UniProt", "db_id": "Q8MJ25" }, { "db_name": "UniProt", "db_id": "Q9PRQ9" } ] }, { "id": "DS.d1212.s0.e4", "type": "protein", "text": [ "motilin" ], "offsets": [ [ 431, 438 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18811" }, { "db_name": "UniProt", "db_id": "O18845" }, { "db_name": "UniProt", "db_id": "O46617" }, { "db_name": "UniProt", "db_id": "O62820" }, { "db_name": "UniProt", "db_id": "P01307" }, { "db_name": "UniProt", "db_id": "P12872" }, { "db_name": "UniProt", "db_id": "P19863" }, { "db_name": "UniProt", "db_id": "P27114" }, { "db_name": "UniProt", "db_id": "Q99MP5" }, { "db_name": "UniProt", "db_id": "Q9PRP6" }, { "db_name": 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{ "db_name": "UniProt", "db_id": "Q9PT99" }, { "db_name": "UniProt", "db_id": "Q9TR93" } ] }, { "id": "DS.d1212.s0.e6", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 465, 472 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", 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"P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1212.s1.e0", "type": "compound", "text": [ "somatostatin" ], "offsets": [ [ 516, 528 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16129681" }, { "db_name": "PubChem", "db_id": "16129706" } ] }, { "id": "DS.d1212.s1.e1", "type": "compound", "text": [ "5-HT" ], "offsets": [ [ 530, 534 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5202" } ] }, { "id": "DS.d1212.s1.e2", "type": "protein", "text": [ "PYY" ], "offsets": [ [ 539, 542 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P09641" }, { "db_name": "UniProt", "db_id": "P10082" }, { "db_name": "UniProt", "db_id": "P10631" }, { "db_name": "UniProt", "db_id": "P29203" }, { "db_name": "UniProt", "db_id": "P29204" }, { "db_name": "UniProt", "db_id": "P29205" }, { "db_name": "UniProt", "db_id": "P29206" }, { "db_name": "UniProt", "db_id": "P48098" }, { "db_name": "UniProt", "db_id": "P51694" }, { "db_name": "UniProt", "db_id": "P68004" }, { "db_name": "UniProt", "db_id": "P68005" }, { "db_name": "UniProt", "db_id": "P69092" }, { "db_name": "UniProt", "db_id": "P69093" }, { "db_name": "UniProt", "db_id": "P69094" }, { "db_name": "UniProt", "db_id": "P69095" }, { "db_name": "UniProt", "db_id": "P69096" }, { "db_name": "UniProt", "db_id": "P81028" }, { "db_name": "UniProt", "db_id": "Q76CL2" }, { "db_name": "UniProt", "db_id": "Q9EPS2" }, { "db_name": "UniProt", "db_id": "Q9PT99" }, { "db_name": "UniProt", "db_id": "Q9TR93" } ] }, { "id": "DS.d1212.s1.e3", "type": "protein", "text": [ "glucagon" ], "offsets": [ [ 580, 588 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12956" }, { "db_name": "UniProt", "db_id": "O42143" }, { "db_name": "UniProt", "db_id": "O42144" }, { "db_name": "UniProt", "db_id": "P01272" }, { "db_name": "UniProt", "db_id": "P01273" }, { "db_name": "UniProt", "db_id": "P01274" }, { "db_name": "UniProt", "db_id": "P01275" }, { "db_name": "UniProt", "db_id": "P04093" }, { "db_name": "UniProt", "db_id": "P05110" }, { "db_name": "UniProt", "db_id": "P06883" }, { "db_name": "UniProt", "db_id": "P07449" }, { "db_name": "UniProt", "db_id": "P09566" }, { "db_name": "UniProt", "db_id": "P09567" }, { "db_name": "UniProt", "db_id": "P09682" }, { "db_name": "UniProt", "db_id": "P09686" }, { "db_name": "UniProt", "db_id": "P0C235" }, { "db_name": "UniProt", "db_id": "P13189" }, { "db_name": "UniProt", "db_id": "P15438" }, { "db_name": "UniProt", "db_id": "P18108" }, { "db_name": "UniProt", "db_id": "P22890" }, { "db_name": "UniProt", "db_id": "P29794" }, { "db_name": "UniProt", "db_id": "P31297" }, { "db_name": "UniProt", "db_id": "P33528" }, { "db_name": "UniProt", "db_id": "P55095" }, { "db_name": "UniProt", "db_id": "P68259" }, { "db_name": "UniProt", "db_id": "P68260" }, { "db_name": "UniProt", "db_id": "P68273" }, { "db_name": "UniProt", "db_id": "P68274" }, { "db_name": "UniProt", "db_id": "P68275" }, { "db_name": "UniProt", "db_id": "P68952" }, { "db_name": "UniProt", "db_id": "P68953" }, { "db_name": "UniProt", "db_id": "P68954" }, { "db_name": "UniProt", "db_id": "P68955" }, { "db_name": "UniProt", "db_id": "P68956" }, { "db_name": "UniProt", "db_id": "P68957" }, { "db_name": "UniProt", "db_id": "P79695" }, { "db_name": "UniProt", "db_id": "P81880" }, { "db_name": "UniProt", "db_id": "Q8MJ25" }, { "db_name": "UniProt", "db_id": "Q9PRQ9" } ] }, { "id": "DS.d1212.s1.e4", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 593, 600 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1212.s2.e0", "type": "compound", "text": [ "5-HT" ], "offsets": [ [ 671, 675 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5202" } ] }, { "id": "DS.d1212.s2.e1", "type": "compound", "text": [ "somatostatin" ], "offsets": [ [ 716, 728 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16129681" }, { "db_name": "PubChem", "db_id": "16129706" } ] }, { "id": "DS.d1212.s2.e2", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 733, 740 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
[]
DS.d1213
18799634
[ { "id": "DS.d1213.s0", "type": "", "text": [ "Cell fractionation by sucrose gradient and differential centrifugation demonstrated that in bradykinin-stimulated cells, TRPM7 localized in fractions corresponding to caveolae." ], "offsets": [ [ 0, 176 ] ] } ]
[ { "id": "DS.d1213.s0.e0", "type": "compound", "text": [ "sucrose" ], "offsets": [ [ 22, 29 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5988" } ] }, { "id": "DS.d1213.s0.e1", "type": "protein", "text": [ "TRPM7" ], "offsets": [ [ 121, 126 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q96QT4" } ] } ]
[]
[]
[]
DS.d1214
18799753
[ { "id": "DS.d1214.s0", "type": "", "text": [ "However, there are conflicting data regarding the role of Gpr30 as an estrogen receptor (ER): several laboratories were unable to demonstrate estradiol binding to GPR30 or estradiol-activated signal transduction in Gpr30-expressing cells." ], "offsets": [ [ 0, 238 ] ] }, { "id": "DS.d1214.s1", "type": "", "text": [ "Our data demonstrate that in vivo Gpr30 is dispensable for the mediation of estradiol effects in reproductive organs." ], "offsets": [ [ 239, 356 ] ] } ]
[ { "id": "DS.d1214.s0.e0", "type": "protein", "text": [ "estrogen receptor" ], "offsets": [ [ 70, 87 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42132" }, { "db_name": "UniProt", "db_id": "P03372" }, { "db_name": "UniProt", "db_id": "P06211" }, { "db_name": "UniProt", "db_id": "P06212" }, { "db_name": "UniProt", "db_id": "P16058" }, { "db_name": "UniProt", "db_id": "P19785" }, { "db_name": "UniProt", "db_id": "P49884" }, { "db_name": "UniProt", "db_id": "P49885" }, { "db_name": "UniProt", "db_id": "P49886" }, { "db_name": "UniProt", "db_id": "P50240" }, { "db_name": "UniProt", "db_id": "P50241" }, { "db_name": "UniProt", "db_id": "P50242" }, { "db_name": "UniProt", "db_id": "P57717" }, { "db_name": "UniProt", "db_id": "P57753" }, { "db_name": "UniProt", "db_id": "P81559" }, { "db_name": "UniProt", "db_id": "Q29040" }, { "db_name": "UniProt", "db_id": "Q53AD2" }, { "db_name": "UniProt", "db_id": "Q91250" }, { "db_name": "UniProt", "db_id": "Q91424" }, { "db_name": "UniProt", "db_id": "Q9PVZ9" }, { "db_name": "UniProt", "db_id": "Q9QZJ5" }, { "db_name": "UniProt", "db_id": "Q9TV98" }, { "db_name": "UniProt", "db_id": "Q9YH33" }, { "db_name": "UniProt", "db_id": "Q9YHT3" }, { "db_name": "UniProt", "db_id": "Q9YHZ7" } ] }, { "id": "DS.d1214.s0.e1", "type": "compound", "text": [ "estradiol" ], "offsets": [ [ 142, 151 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5757" } ] }, { "id": "DS.d1214.s0.e2", "type": "compound", "text": [ "estradiol" ], "offsets": [ [ 172, 181 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5757" } ] }, { "id": "DS.d1214.s1.e0", "type": "protein", "text": [ "Gpr30" ], "offsets": [ [ 273, 278 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08878" }, { "db_name": "UniProt", "db_id": "Q8BMP4" } ] }, { "id": "DS.d1214.s1.e1", "type": "compound", "text": [ "estradiol" ], "offsets": [ [ 315, 324 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5757" } ] } ]
[]
[]
[]
DS.d1215
18799757
[ { "id": "DS.d1215.s0", "type": "", "text": [ "Sorbitol can fuel mouse sperm motility and protein tyrosine phosphorylation via sorbitol dehydrogenase." ], "offsets": [ [ 0, 103 ] ] }, { "id": "DS.d1215.s1", "type": "", "text": [ "Here we characterize Sord mRNA and SORD expression during mouse spermatogenesis and examine the ability of sorbitol to support epididymal sperm motility and tyrosine phosphorylation." ], "offsets": [ [ 104, 286 ] ] } ]
[ { "id": "DS.d1215.s0.e0", "type": "compound", "text": [ "Sorbitol" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5780" } ] }, { "id": "DS.d1215.s0.e1", "type": "compound", "text": [ "tyrosine" ], "offsets": [ [ 51, 59 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1153" }, { "db_name": "PubChem", "db_id": "6057" }, { "db_name": "PubChem", "db_id": "5460803" } ] }, { "id": "DS.d1215.s0.e2", "type": "protein", "text": [ "sorbitol dehydrogenase" ], "offsets": [ [ 80, 102 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07846" }, { "db_name": "UniProt", "db_id": "P27867" }, { "db_name": "UniProt", "db_id": "Q00796" }, { "db_name": "UniProt", "db_id": "Q02912" }, { "db_name": "UniProt", "db_id": "Q06004" }, { "db_name": "UniProt", "db_id": "Q29318" }, { "db_name": "UniProt", "db_id": "Q4R639" }, { "db_name": "UniProt", "db_id": "Q58D31" }, { "db_name": "UniProt", "db_id": "Q59787" }, { "db_name": "UniProt", "db_id": "Q64442" }, { "db_name": "UniProt", "db_id": "Q9Z9U1" } ] }, { "id": "DS.d1215.s1.e0", "type": "protein", "text": [ "Sord" ], "offsets": [ [ 125, 129 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27867" }, { "db_name": "UniProt", "db_id": "Q64442" } ] }, { "id": "DS.d1215.s1.e1", "type": "protein", "text": [ "SORD" ], "offsets": [ [ 139, 143 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07846" }, { "db_name": "UniProt", "db_id": "Q00796" }, { "db_name": "UniProt", "db_id": "Q29318" }, { "db_name": "UniProt", "db_id": "Q4R639" }, { "db_name": "UniProt", "db_id": "Q58D31" } ] }, { "id": "DS.d1215.s1.e2", "type": "compound", "text": [ "sorbitol" ], "offsets": [ [ 211, 219 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5780" } ] }, { "id": "DS.d1215.s1.e3", "type": "compound", "text": [ "tyrosine" ], "offsets": [ [ 261, 269 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1153" }, { "db_name": "PubChem", "db_id": "6057" }, { "db_name": "PubChem", "db_id": "5460803" } ] } ]
[]
[]
[ { "id": "DS.d1215.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1215.s0.e0", "arg2_id": "DS.d1215.s0.e2", "normalized": [] } ]
DS.d1216
18800037
[ { "id": "DS.d1216.s0", "type": "", "text": [ "Increase in sildenafil clearance in the early postnatal period likely reflects maturation of CYP-mediated N-demethylation." ], "offsets": [ [ 0, 122 ] ] } ]
[ { "id": "DS.d1216.s0.e0", "type": "compound", "text": [ "sildenafil" ], "offsets": [ [ 12, 22 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5212" } ] }, { "id": "DS.d1216.s0.e1", "type": "protein", "text": [ "CYP" ], "offsets": [ [ 93, 96 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21568" }, { "db_name": "UniProt", "db_id": "P21569" }, { "db_name": "UniProt", "db_id": "P24525" }, { "db_name": "UniProt", "db_id": "P34887" }, { "db_name": "UniProt", "db_id": "Q26551" } ] } ]
[]
[]
[ { "id": "DS.d1216.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1216.s0.e0", "arg2_id": "DS.d1216.s0.e1", "normalized": [] } ]
DS.d1217
18800064
[ { "id": "DS.d1217.s0", "type": "", "text": [ "Desipramine modulation of alpha-, gamma-synuclein, and the norepinephrine transporter in an animal model of depression." ], "offsets": [ [ 0, 119 ] ] }, { "id": "DS.d1217.s1", "type": "", "text": [ "The NET-selective antidepressant desipramine (DMI) was chronically administered for 14 days to WKY rats and the strain from which it was outbred that does not show depressive-like behavior, the Wistar rat." ], "offsets": [ [ 120, 325 ] ] } ]
[ { "id": "DS.d1217.s0.e0", "type": "compound", "text": [ "Desipramine" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2995" } ] }, { "id": "DS.d1217.s0.e1", "type": "protein", "text": [ "gamma-synuclein" ], "offsets": [ [ 34, 49 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O76070" }, { "db_name": "UniProt", "db_id": "Q2PFW6" }, { "db_name": "UniProt", "db_id": "Q63544" }, { "db_name": "UniProt", "db_id": "Q9NZ50" }, { "db_name": "UniProt", "db_id": "Q9Z0F7" } ] }, { "id": "DS.d1217.s0.e2", "type": "protein", "text": [ "norepinephrine transporter" ], "offsets": [ [ 59, 85 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O55192" }, { "db_name": "UniProt", "db_id": "P23975" }, { "db_name": "UniProt", "db_id": "P51143" } ] }, { "id": "DS.d1217.s1.e0", "type": "protein", "text": [ "NET" ], "offsets": [ [ 124, 127 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O55192" }, { "db_name": "UniProt", "db_id": "P23975" }, { "db_name": "UniProt", "db_id": "P41970" }, { "db_name": "UniProt", "db_id": "P51143" }, { "db_name": "UniProt", "db_id": "P54762" } ] }, { "id": "DS.d1217.s1.e1", "type": "compound", "text": [ "desipramine" ], "offsets": [ [ 153, 164 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2995" } ] } ]
[]
[]
[ { "id": "DS.d1217.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1217.s0.e0", "arg2_id": "DS.d1217.s0.e1", "normalized": [] }, { "id": "DS.d1217.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1217.s0.e0", "arg2_id": "DS.d1217.s0.e2", "normalized": [] }, { "id": "DS.d1217.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1217.s1.e1", "arg2_id": "DS.d1217.s1.e0", "normalized": [] } ]
DS.d1218
18800198
[ { "id": "DS.d1218.s0", "type": "", "text": [ "The present study was designed to evaluate the impact of zinc status before burn on the recovery of injury with focus on plasma insulin and glucose levels." ], "offsets": [ [ 0, 155 ] ] }, { "id": "DS.d1218.s1", "type": "", "text": [ "Blood and tissue samples were collected 3, 6, and 24 h after injury in order to study biochemical parameters and the glucose/insulin response in relation with the zinc status." ], "offsets": [ [ 156, 331 ] ] }, { "id": "DS.d1218.s2", "type": "", "text": [ "In addition, the burn-induced insulin resistance, leading to protein catabolism, was emphasized, with higher plasma insulin, glucose, and leptin levels in zinc-deficient animals versus normal-fed rats." ], "offsets": [ [ 332, 533 ] ] } ]
[ { "id": "DS.d1218.s0.e0", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 128, 135 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1218.s0.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 140, 147 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1218.s1.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 273, 280 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1218.s1.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 281, 288 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1218.s2.e0", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 362, 369 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1218.s2.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 448, 455 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1218.s2.e2", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 457, 464 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1218.s2.e3", "type": "protein", "text": [ "leptin" ], "offsets": [ [ 470, 476 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02750" }, { "db_name": "UniProt", "db_id": "O93416" }, { "db_name": "UniProt", "db_id": "Q28603" }, { "db_name": "UniProt", "db_id": "Q95189" }, { "db_name": "UniProt", "db_id": "Q95234" } ] } ]
[]
[]
[]
DS.d1219
18800204
[ { "id": "DS.d1219.s0", "type": "", "text": [ "methoxyphenoxy)benzyl) morpholine) is a positron emission tomography (PET) radioligand recently applied in clinical studies of norepinephrine transporters (NETs) in the human brain in vivo." ], "offsets": [ [ 0, 189 ] ] } ]
[ { "id": "DS.d1219.s0.e0", "type": "compound", "text": [ "morpholine" ], "offsets": [ [ 23, 33 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "8083" } ] }, { "id": "DS.d1219.s0.e1", "type": "protein", "text": [ "norepinephrine transporters" ], "offsets": [ [ 127, 154 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O55192" }, { "db_name": "UniProt", "db_id": "P23975" }, { "db_name": "UniProt", "db_id": "P51143" } ] }, { "id": "DS.d1219.s0.e2", "type": "protein", "text": [ "NETs" ], "offsets": [ [ 156, 160 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O55192" }, { "db_name": "UniProt", "db_id": "P23975" }, { "db_name": "UniProt", "db_id": "P41970" }, { "db_name": "UniProt", "db_id": "P51143" }, { "db_name": "UniProt", "db_id": "P54762" } ] } ]
[]
[]
[ { "id": "DS.d1219.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1219.s0.e0", "arg2_id": "DS.d1219.s0.e2", "normalized": [] }, { "id": "DS.d1219.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1219.s0.e0", "arg2_id": "DS.d1219.s0.e1", "normalized": [] } ]
DS.d1220
18800231
[ { "id": "DS.d1220.s0", "type": "", "text": [ "The most predictive model of EPO response for the pediatric cohort had, as the major variables, urea clearance x dialysis duration/total body water (Kt/V), urea reduction ratio (URR), intact parathyroid hormone (iPTH), blood loss, normalized protein catabolic rates (nPCR) and indices of malnutrition and inflammation, whereas adults had iron and folate deficiencies as the dominant variables." ], "offsets": [ [ 0, 393 ] ] }, { "id": "DS.d1220.s1", "type": "", "text": [ "In summary EPO resistance in the pediatric dialysis cohort was predicted by nutritional deficits, inflammation, poor dialysis, and hyperparathyroidism, while iron and folate deficits were the major determinants in adults." ], "offsets": [ [ 394, 615 ] ] } ]
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[]
[]
[ { "id": "DS.d1220.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1220.s0.e1", "arg2_id": "DS.d1220.s0.e0", "normalized": [] }, { "id": "DS.d1220.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1220.s0.e3", "arg2_id": "DS.d1220.s0.e0", "normalized": [] }, { "id": "DS.d1220.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1220.s1.e1", "arg2_id": "DS.d1220.s1.e0", "normalized": [] } ]
DS.d1222
18800351
[ { "id": "DS.d1222.s0", "type": "", "text": [ "Diallyl trisulfide selectively causes Bax- and Bak-mediated apoptosis in human lung cancer cells." ], "offsets": [ [ 0, 97 ] ] }, { "id": "DS.d1222.s1", "type": "", "text": [ "The DATS-mediated G2-M phase cell cycle arrest was explained by down-regulation of cyclin-dependent kinase 1 (Cdk1) and cell division cycle 25C protein expression leading to accumulation of Tyr15 phosphorylated (inactive) Cdk1." ], "offsets": [ [ 98, 325 ] ] }, { "id": "DS.d1222.s2", "type": "", "text": [ "Knockdown of Bax and Bak proteins conferred significant protection against DATS-induced apoptotic cytoplasmic histone-associated DNA fragmentation." ], "offsets": [ [ 326, 473 ] ] } ]
[ { "id": "DS.d1222.s0.e0", "type": "compound", "text": [ "Diallyl trisulfide" ], "offsets": [ [ 0, 18 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16315" } ] }, { "id": "DS.d1222.s0.e1", "type": "protein", "text": [ "Bax" ], "offsets": [ [ 38, 41 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27297" }, { "db_name": "UniProt", "db_id": "Q07813" }, { "db_name": "UniProt", "db_id": "Q63690" } ] }, { "id": "DS.d1222.s0.e2", "type": "protein", "text": [ "Bak" ], "offsets": [ [ 47, 50 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08734" } ] }, { "id": "DS.d1222.s1.e0", "type": "compound", "text": [ "DATS" ], "offsets": [ [ 102, 106 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "75552" } ] }, { "id": "DS.d1222.s1.e1", "type": "protein", "text": [ "cyclin-dependent kinase 1" ], "offsets": [ [ 181, 206 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06493" }, { "db_name": "UniProt", "db_id": "P11440" }, { "db_name": "UniProt", "db_id": "P13863" }, { "db_name": "UniProt", "db_id": "P39951" }, { "db_name": "UniProt", "db_id": "P48734" }, { "db_name": "UniProt", "db_id": "P51958" }, { "db_name": "UniProt", "db_id": "Q5RCH1" }, { "db_name": "UniProt", "db_id": "Q9DG98" }, { "db_name": "UniProt", "db_id": "Q9DGA2" }, { "db_name": "UniProt", "db_id": "Q9DGA5" }, { "db_name": "UniProt", "db_id": "Q9DGD3" } ] }, { "id": "DS.d1222.s1.e2", "type": "protein", "text": [ "Cdk1" ], "offsets": [ [ 208, 212 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P34556" } ] }, { "id": "DS.d1222.s1.e3", "type": "protein", "text": [ "Cdk1" ], "offsets": [ [ 320, 324 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P34556" } ] }, { "id": "DS.d1222.s2.e0", "type": "protein", "text": [ "Bax" ], "offsets": [ [ 339, 342 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27297" }, { "db_name": "UniProt", "db_id": "Q07813" }, { "db_name": "UniProt", "db_id": "Q63690" } ] }, { "id": "DS.d1222.s2.e1", "type": "protein", "text": [ "Bak" ], "offsets": [ [ 347, 350 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08734" } ] }, { "id": "DS.d1222.s2.e2", "type": "compound", "text": [ "DATS" ], "offsets": [ [ 401, 405 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "75552" } ] } ]
[]
[]
[ { "id": "DS.d1222.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1222.s0.e0", "arg2_id": "DS.d1222.s0.e2", "normalized": [] }, { "id": "DS.d1222.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1222.s0.e0", "arg2_id": "DS.d1222.s0.e1", "normalized": [] }, { "id": "DS.d1222.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1222.s1.e0", "arg2_id": "DS.d1222.s1.e2", "normalized": [] }, { "id": "DS.d1222.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1222.s1.e0", "arg2_id": "DS.d1222.s1.e1", "normalized": [] } ]
DS.d1223
18800985
[ { "id": "DS.d1223.s0", "type": "", "text": [ "In the present work, we showed for the first time that synthetic oligodeoxynucleotides containing unmethylated cytosine guanine motifs (CpG) are able to stimulate, in the presence of interferon-gamma (IFN-gamma), both arginase and inducible nitric oxide synthase (iNOS) in murine Mphi." ], "offsets": [ [ 0, 285 ] ] }, { "id": "DS.d1223.s1", "type": "", "text": [ "A significant increase in arginase activity was observed upon a short pre-incubation (1 hr) with IFN-gamma and subsequent CpG stimulation." ], "offsets": [ [ 286, 424 ] ] }, { "id": "DS.d1223.s2", "type": "", "text": [ "Therefore, a very interesting observation of this study was that the CpG-mediated arginase activity is dependent on IFN-gamma priming." ], "offsets": [ [ 425, 559 ] ] }, { "id": "DS.d1223.s3", "type": "", "text": [ "This report reveals a singular effect of the combination of CpG and IFN-gamma, one of the mayor cytokines produced in response to CpG administration in vivo." ], "offsets": [ [ 560, 717 ] ] } ]
[ { "id": "DS.d1223.s0.e2", "type": "compound", "text": [ "CpG" ], "offsets": [ [ 136, 139 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6804" } ] }, { "id": "DS.d1223.s0.e3", "type": "protein", "text": [ "interferon-gamma" ], "offsets": [ [ 183, 199 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9TTB0" } ] }, { "id": "DS.d1223.s0.e4", "type": "protein", "text": [ "IFN-gamma" ], "offsets": [ [ 201, 210 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35497" }, { "db_name": "UniProt", "db_id": "O35735" }, { "db_name": "UniProt", "db_id": "O57571" }, { "db_name": "UniProt", "db_id": "O57603" }, { "db_name": "UniProt", "db_id": "O57608" }, { "db_name": "UniProt", "db_id": "O73915" }, { "db_name": "UniProt", "db_id": "O77763" }, { "db_name": "UniProt", "db_id": "P01579" }, { "db_name": "UniProt", "db_id": "P01580" }, { "db_name": "UniProt", "db_id": "P01581" }, { "db_name": "UniProt", "db_id": "P07353" }, { "db_name": "UniProt", "db_id": "P17773" }, { "db_name": "UniProt", "db_id": "P17803" }, { "db_name": "UniProt", "db_id": "P28333" }, { "db_name": "UniProt", "db_id": "P28341" }, { "db_name": "UniProt", "db_id": "P30123" }, { "db_name": "UniProt", "db_id": "P42160" }, { "db_name": "UniProt", "db_id": "P42161" }, { "db_name": "UniProt", "db_id": "P42162" }, { "db_name": "UniProt", "db_id": "P46402" }, { "db_name": "UniProt", "db_id": "P49708" }, { "db_name": "UniProt", "db_id": "P63309" }, { "db_name": "UniProt", "db_id": "P63310" }, { "db_name": "UniProt", "db_id": "P63311" }, { "db_name": "UniProt", "db_id": "P79154" }, { "db_name": "UniProt", "db_id": "Q1WM28" }, { "db_name": "UniProt", "db_id": "Q25BC0" }, { "db_name": "UniProt", "db_id": "Q2PE75" }, { "db_name": "UniProt", "db_id": "Q4ZH68" }, { "db_name": "UniProt", "db_id": "Q5CCK0" }, { "db_name": "UniProt", "db_id": "Q5I6S9" }, { "db_name": "UniProt", "db_id": "Q62574" }, { "db_name": "UniProt", "db_id": "Q647G2" }, { "db_name": "UniProt", "db_id": "Q7TSP4" }, { "db_name": "UniProt", "db_id": "Q865W6" }, { "db_name": "UniProt", "db_id": "Q865X1" }, { "db_name": "UniProt", "db_id": "Q865Y4" }, { "db_name": "UniProt", "db_id": "Q866Y6" }, { "db_name": "UniProt", "db_id": "Q8MKF5" }, { "db_name": "UniProt", "db_id": "Q8SPW9" }, { "db_name": "UniProt", "db_id": "Q9QXX2" }, { "db_name": "UniProt", "db_id": "Q9TTB0" }, { "db_name": "UniProt", "db_id": "Q9TV67" }, { "db_name": "UniProt", "db_id": "Q9YGB9" } ] }, { "id": "DS.d1223.s0.e5", "type": "protein", "text": [ "arginase" ], "offsets": [ [ 218, 226 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O49046" }, { "db_name": "UniProt", "db_id": "P00812" }, { "db_name": "UniProt", "db_id": "P0A2X9" }, { "db_name": "UniProt", "db_id": "P0A2Y0" }, { "db_name": "UniProt", "db_id": "P0A2Y1" }, { "db_name": "UniProt", "db_id": "P14012" }, { "db_name": "UniProt", "db_id": "P33280" }, { "db_name": "UniProt", "db_id": "P37818" }, { "db_name": "UniProt", "db_id": "P39138" }, { "db_name": "UniProt", "db_id": "P40906" }, { "db_name": "UniProt", "db_id": "P46637" }, { "db_name": "UniProt", "db_id": "P53608" }, { "db_name": "UniProt", "db_id": "P60086" }, { "db_name": "UniProt", "db_id": "P60087" }, { "db_name": "UniProt", "db_id": "P60088" }, { "db_name": "UniProt", "db_id": "Q10066" }, { "db_name": "UniProt", "db_id": "Q12611" }, { "db_name": "UniProt", "db_id": "Q1E180" }, { "db_name": "UniProt", "db_id": "Q6G7E9" }, { "db_name": "UniProt", "db_id": "Q6GER3" }, { "db_name": "UniProt", "db_id": "Q74ZW4" }, { "db_name": "UniProt", "db_id": "Q7M0Z3" }, { "db_name": "UniProt", "db_id": "Q8NVE3" } ] }, { "id": "DS.d1223.s0.e6", "type": "protein", "text": [ "nitric oxide synthase" ], "offsets": [ [ 241, 262 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d1223.s0.e7", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 264, 268 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d1223.s1.e0", "type": "protein", "text": [ "arginase" ], "offsets": [ [ 312, 320 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O49046" }, { "db_name": "UniProt", "db_id": "P00812" }, { "db_name": "UniProt", "db_id": "P0A2X9" }, { "db_name": "UniProt", "db_id": "P0A2Y0" }, { "db_name": "UniProt", "db_id": "P0A2Y1" }, { "db_name": "UniProt", "db_id": "P14012" }, { "db_name": "UniProt", "db_id": "P33280" }, { "db_name": "UniProt", "db_id": "P37818" }, { "db_name": "UniProt", "db_id": "P39138" }, { "db_name": "UniProt", "db_id": "P40906" }, { "db_name": "UniProt", "db_id": "P46637" }, { "db_name": "UniProt", "db_id": "P53608" }, { "db_name": "UniProt", "db_id": "P60086" }, { "db_name": "UniProt", "db_id": "P60087" }, { "db_name": "UniProt", "db_id": "P60088" }, { "db_name": "UniProt", "db_id": "Q10066" }, { "db_name": "UniProt", "db_id": "Q12611" }, { "db_name": "UniProt", "db_id": "Q1E180" }, { "db_name": "UniProt", "db_id": "Q6G7E9" }, { "db_name": "UniProt", "db_id": "Q6GER3" }, { "db_name": "UniProt", "db_id": "Q74ZW4" }, { "db_name": "UniProt", "db_id": "Q7M0Z3" }, { "db_name": "UniProt", "db_id": "Q8NVE3" } ] }, { "id": "DS.d1223.s1.e1", "type": "protein", "text": [ "IFN-gamma" ], "offsets": [ [ 383, 392 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35497" }, { "db_name": "UniProt", "db_id": "O35735" }, { "db_name": "UniProt", "db_id": "O57571" }, { "db_name": "UniProt", "db_id": "O57603" }, { "db_name": "UniProt", "db_id": "O57608" }, { "db_name": "UniProt", "db_id": "O73915" }, { "db_name": "UniProt", "db_id": "O77763" }, { "db_name": "UniProt", "db_id": "P01579" }, { "db_name": "UniProt", "db_id": "P01580" }, { "db_name": "UniProt", "db_id": "P01581" }, { "db_name": "UniProt", "db_id": "P07353" }, { "db_name": "UniProt", "db_id": "P17773" }, { "db_name": "UniProt", "db_id": "P17803" }, { "db_name": "UniProt", "db_id": "P28333" }, { "db_name": "UniProt", "db_id": "P28341" }, { "db_name": "UniProt", "db_id": "P30123" }, { "db_name": "UniProt", "db_id": "P42160" }, { "db_name": "UniProt", "db_id": "P42161" }, { "db_name": "UniProt", "db_id": "P42162" }, { "db_name": "UniProt", "db_id": "P46402" }, { "db_name": "UniProt", "db_id": "P49708" }, { "db_name": "UniProt", "db_id": "P63309" }, { "db_name": "UniProt", "db_id": "P63310" }, { "db_name": "UniProt", "db_id": "P63311" }, { "db_name": "UniProt", "db_id": "P79154" }, { "db_name": "UniProt", "db_id": "Q1WM28" }, { "db_name": "UniProt", "db_id": "Q25BC0" }, { "db_name": "UniProt", "db_id": "Q2PE75" }, { "db_name": "UniProt", "db_id": "Q4ZH68" }, { "db_name": "UniProt", "db_id": "Q5CCK0" }, { "db_name": "UniProt", "db_id": "Q5I6S9" }, { "db_name": "UniProt", "db_id": "Q62574" }, { "db_name": "UniProt", "db_id": "Q647G2" }, { "db_name": "UniProt", "db_id": "Q7TSP4" }, { "db_name": "UniProt", "db_id": "Q865W6" }, { "db_name": "UniProt", "db_id": "Q865X1" }, { "db_name": "UniProt", "db_id": "Q865Y4" }, { "db_name": "UniProt", "db_id": "Q866Y6" }, { "db_name": "UniProt", "db_id": "Q8MKF5" }, { "db_name": "UniProt", "db_id": "Q8SPW9" }, { "db_name": "UniProt", "db_id": "Q9QXX2" }, { "db_name": "UniProt", "db_id": "Q9TTB0" }, { "db_name": "UniProt", "db_id": "Q9TV67" }, { "db_name": "UniProt", "db_id": "Q9YGB9" } ] }, { "id": "DS.d1223.s1.e2", "type": "compound", "text": [ "CpG" ], "offsets": [ [ 408, 411 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6804" } ] }, { "id": "DS.d1223.s2.e0", "type": "compound", "text": [ "CpG" ], "offsets": [ [ 494, 497 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6804" } ] }, { "id": "DS.d1223.s2.e1", "type": "protein", "text": [ "arginase" ], "offsets": [ [ 507, 515 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O49046" }, { "db_name": "UniProt", "db_id": "P00812" }, { "db_name": "UniProt", "db_id": "P0A2X9" }, { "db_name": "UniProt", "db_id": "P0A2Y0" }, { "db_name": "UniProt", "db_id": "P0A2Y1" }, { "db_name": "UniProt", "db_id": "P14012" }, { "db_name": "UniProt", "db_id": "P33280" }, { "db_name": "UniProt", "db_id": "P37818" }, { "db_name": "UniProt", "db_id": "P39138" }, { "db_name": "UniProt", "db_id": "P40906" }, { "db_name": "UniProt", "db_id": "P46637" }, { "db_name": "UniProt", "db_id": "P53608" }, { "db_name": "UniProt", "db_id": "P60086" }, { "db_name": "UniProt", "db_id": "P60087" }, { "db_name": "UniProt", "db_id": "P60088" }, { "db_name": 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}, { "db_name": "UniProt", "db_id": "Q865W6" }, { "db_name": "UniProt", "db_id": "Q865X1" }, { "db_name": "UniProt", "db_id": "Q865Y4" }, { "db_name": "UniProt", "db_id": "Q866Y6" }, { "db_name": "UniProt", "db_id": "Q8MKF5" }, { "db_name": "UniProt", "db_id": "Q8SPW9" }, { "db_name": "UniProt", "db_id": "Q9QXX2" }, { "db_name": "UniProt", "db_id": "Q9TTB0" }, { "db_name": "UniProt", "db_id": "Q9TV67" }, { "db_name": "UniProt", "db_id": "Q9YGB9" } ] }, { "id": "DS.d1223.s3.e0", "type": "compound", "text": [ "CpG" ], "offsets": [ [ 620, 623 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6804" } ] }, { "id": "DS.d1223.s3.e1", "type": "protein", "text": [ "IFN-gamma" ], "offsets": [ [ 628, 637 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35497" }, { "db_name": "UniProt", "db_id": "O35735" }, { "db_name": "UniProt", "db_id": "O57571" }, { "db_name": "UniProt", "db_id": "O57603" }, { "db_name": "UniProt", "db_id": "O57608" }, { "db_name": "UniProt", "db_id": "O73915" }, { 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[]
[]
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DS.d1224
18801207
[ { "id": "DS.d1224.s0", "type": "", "text": [ "Bakuchiol has a three-fold higher binding affinity for ERalpha than for ERbeta." ], "offsets": [ [ 0, 79 ] ] } ]
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[]
[]
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DS.d1226
18801483
[ { "id": "DS.d1226.s0", "type": "", "text": [ "In the present study, we examined the effect of gliclazide, a second generation sulfonylurea with antioxidant properties, on LOX-1 expression and LOX-1-mediated MMP-9 expression and apoptosis in oxLDL-treated human aortic endothelial cells (HAECs)." ], "offsets": [ [ 0, 248 ] ] } ]
[ { "id": "DS.d1226.s0.e0", "type": "compound", "text": [ "gliclazide" ], "offsets": [ [ 48, 58 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3475" } ] }, { "id": "DS.d1226.s0.e1", "type": "compound", "text": [ "sulfonylurea" ], "offsets": [ [ 80, 92 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104818" } ] }, { "id": "DS.d1226.s0.e2", "type": "protein", "text": [ "LOX-1" ], "offsets": [ [ 125, 130 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O70156" }, { "db_name": "UniProt", "db_id": "P78380" }, { "db_name": "UniProt", "db_id": "P79391" }, { "db_name": "UniProt", "db_id": "Q9EQ09" }, { "db_name": "UniProt", "db_id": "Q9TTK7" }, { "db_name": "UniProt", "db_id": "Q9XTA8" } ] }, { "id": "DS.d1226.s0.e3", "type": "protein", "text": [ "LOX-1" ], "offsets": [ [ 146, 151 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O70156" }, { "db_name": "UniProt", "db_id": "P78380" }, { "db_name": "UniProt", "db_id": "P79391" }, { "db_name": "UniProt", "db_id": "Q9EQ09" }, { "db_name": "UniProt", "db_id": "Q9TTK7" }, { "db_name": "UniProt", "db_id": "Q9XTA8" } ] }, { "id": "DS.d1226.s0.e4", "type": "protein", "text": [ "MMP-9" ], "offsets": [ [ 161, 166 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18733" }, { "db_name": "UniProt", "db_id": "P14780" }, { "db_name": "UniProt", "db_id": "P41245" }, { "db_name": "UniProt", "db_id": "P41246" }, { "db_name": "UniProt", "db_id": "P50282" }, { "db_name": "UniProt", "db_id": "P52176" } ] } ]
[]
[]
[ { "id": "DS.d1226.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1226.s0.e0", "arg2_id": "DS.d1226.s0.e4", "normalized": [] }, { "id": "DS.d1226.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1226.s0.e0", "arg2_id": "DS.d1226.s0.e2", "normalized": [] } ]
DS.d1227
18801573
[ { "id": "DS.d1227.s0", "type": "", "text": [ "The phenolics: anthocyanin (ATH), sinapoyl esters and activity of antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (POX), ascorbate peroxidase (APX), glutathione peroxidase (GPX) and glutathione reductase (GR), in red cabbage seedlings subjected to Cu2+ stress were investigated." ], "offsets": [ [ 0, 315 ] ] }, { "id": "DS.d1227.s1", "type": "", "text": [ "It could results from the fact that phenolic compounds (PhC), which could be also substrates for different peroxidases, were the first line of defence against metal stress." ], "offsets": [ [ 316, 488 ] ] } ]
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"O32770" }, { "db_name": "UniProt", "db_id": "O59858" }, { "db_name": "UniProt", "db_id": "Q00277" }, { "db_name": "UniProt", "db_id": "Q9CFV1" } ] }, { "id": "DS.d1227.s0.e10", "type": "protein", "text": [ "GPX" ], "offsets": [ [ 210, 213 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77834" }, { "db_name": "UniProt", "db_id": "P83564" }, { "db_name": "UniProt", "db_id": "Q00277" } ] }, { "id": "DS.d1227.s0.e11", "type": "protein", "text": [ "glutathione reductase" ], "offsets": [ [ 219, 240 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15770" }, { "db_name": "UniProt", "db_id": "P06715" }, { "db_name": "UniProt", "db_id": "P11804" }, { "db_name": "UniProt", "db_id": "P23189" }, { "db_name": "UniProt", "db_id": "P41921" }, { "db_name": "UniProt", "db_id": "P43783" }, { "db_name": "UniProt", "db_id": "P48638" }, { "db_name": "UniProt", "db_id": "P48639" }, { "db_name": "UniProt", "db_id": "P70619" }, { "db_name": "UniProt", "db_id": "P78965" }, { "db_name": "UniProt", "db_id": "Q60151" }, { "db_name": "UniProt", "db_id": "Q6BPI1" }, { "db_name": "UniProt", "db_id": "Q6C5H4" }, { "db_name": "UniProt", "db_id": "Q6FRV2" }, { "db_name": "UniProt", "db_id": "Q6HA23" }, { "db_name": "UniProt", "db_id": "Q74ZK4" }, { "db_name": "UniProt", "db_id": "Q873E8" }, { "db_name": "UniProt", "db_id": "Q94655" } ] }, { "id": "DS.d1227.s1.e0", "type": "compound", "text": [ "PhC" ], "offsets": [ [ 372, 375 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444567" } ] }, { "id": "DS.d1227.s1.e1", "type": "protein", "text": [ "peroxidases" ], "offsets": [ [ 423, 434 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15984" }, { "db_name": "UniProt", "db_id": "P16147" }, { "db_name": "UniProt", "db_id": "P84714" } ] } ]
[]
[]
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DS.d1228
18801652
[ { "id": "DS.d1228.s0", "type": "", "text": [ "The affinity characteristics of developed immunosensors were investigated in reaction with microcystin-LR, and PSA." ], "offsets": [ [ 0, 115 ] ] }, { "id": "DS.d1228.s1", "type": "", "text": [ "The detection limit for microcystin-LR was 10 ngmL(-1) and for PSA 0.01 ngmL(-1)." ], "offsets": [ [ 116, 197 ] ] } ]
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[]
[]
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DS.d1229
18801682
[ { "id": "DS.d1229.s0", "type": "", "text": [ "This was achieved by (1) direct comparison of the sensitivity of ASIC1, ASIC2, ASIC3 and TRPV1 knockout mice versus wildtype littermates to acute thermal and mechanical noxious stimuli and (2) studying the behavioural responses of each transgenic strain to hind paw inflammation with either complete Freund's adjuvant (CFA) or formalin." ], "offsets": [ [ 0, 336 ] ] }, { "id": "DS.d1229.s1", "type": "", "text": [ "Following formalin injection, ASIC1 (-/-) and ASIC2 (-/-), but not ASIC3 (-/-) or TRPV1 (-/-), mice showed enhanced pain behaviour, predominantly in the second phase of the test." ], "offsets": [ [ 337, 515 ] ] } ]
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[]
[]
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DS.d1230
18801894
[ { "id": "DS.d1230.s0", "type": "", "text": [ "The biochemical parameters studied are: albumin (ALB), alanine aminotransferase (ALT), amylase (AMY), total bilirubin (TBI), blood urea nitrogen (BUN), creatinine (CRE), glucose, globulin, total proteins (TP), and the ions calcium, phosphorus, sodium, and potassium." ], "offsets": [ [ 0, 266 ] ] } ]
[ { "id": "DS.d1230.s0.e0", "type": "protein", "text": [ "ALB" ], "offsets": [ [ 49, 52 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35090" }, { "db_name": "UniProt", "db_id": "P02768" }, { "db_name": "UniProt", "db_id": "P02769" }, { "db_name": "UniProt", "db_id": "P08835" }, { "db_name": "UniProt", "db_id": "P14639" }, { "db_name": "UniProt", "db_id": "P19121" }, { "db_name": "UniProt", "db_id": "P21847" }, { "db_name": "UniProt", "db_id": "P35747" }, { "db_name": "UniProt", "db_id": "P49064" }, { "db_name": "UniProt", "db_id": "P49065" }, { "db_name": "UniProt", "db_id": "P49822" }, { "db_name": "UniProt", "db_id": "Q28522" }, { "db_name": "UniProt", "db_id": "Q5XLE4" } ] }, { "id": "DS.d1230.s0.e1", "type": "protein", "text": [ "AMY" ], "offsets": [ [ 96, 99 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9BXS0" } ] }, { "id": "DS.d1230.s0.e2", "type": "compound", "text": [ "bilirubin" ], "offsets": [ [ 108, 117 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280352" } ] }, { "id": "DS.d1230.s0.e3", "type": "compound", "text": [ "creatinine" ], "offsets": [ [ 152, 162 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "588" } ] }, { "id": "DS.d1230.s0.e4", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 170, 177 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1230.s0.e5", "type": "compound", "text": [ "phosphorus" ], "offsets": [ [ 232, 242 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24404" }, { "db_name": "PubChem", "db_id": "139579" } ] } ]
[]
[]
[]
DS.d1231
18801899
[ { "id": "DS.d1231.s0", "type": "", "text": [ "In addition, serum levels of glucose, adiponectin, and insulin were measured." ], "offsets": [ [ 0, 77 ] ] }, { "id": "DS.d1231.s1", "type": "", "text": [ "In addition, adenosine monophosphate-activated protein kinase levels were high during fasting and low during HF diet." ], "offsets": [ [ 78, 195 ] ] } ]
[ { "id": "DS.d1231.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 29, 36 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1231.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 55, 62 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1231.s1.e0", "type": "compound", "text": [ "adenosine monophosphate" ], "offsets": [ [ 91, 114 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6083" } ] }, { "id": "DS.d1231.s1.e1", "type": "protein", "text": [ "protein kinase" ], "offsets": [ [ 125, 139 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00513" }, { "db_name": "UniProt", "db_id": "P25848" } ] } ]
[]
[]
[ { "id": "DS.d1231.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1231.s1.e0", "arg2_id": "DS.d1231.s1.e1", "normalized": [] } ]
DS.d1232
18801901
[ { "id": "DS.d1232.s0", "type": "", "text": [ "This action of IGF-I was abolished by SB 212090 but not by wortmannin." ], "offsets": [ [ 0, 70 ] ] } ]
[ { "id": "DS.d1232.s0.e0", "type": "protein", "text": [ "IGF-I" ], "offsets": [ [ 15, 20 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05017" }, { "db_name": "UniProt", "db_id": "P07455" }, { "db_name": "UniProt", "db_id": "P08025" }, { "db_name": "UniProt", "db_id": "P10763" }, { "db_name": "UniProt", "db_id": "P16545" }, { "db_name": "UniProt", "db_id": "P17085" }, { "db_name": "UniProt", "db_id": "P17647" }, { "db_name": "UniProt", "db_id": "P18254" }, { "db_name": "UniProt", "db_id": "P33712" }, { "db_name": "UniProt", "db_id": "P51457" }, { "db_name": "UniProt", "db_id": "P51458" }, { "db_name": "UniProt", "db_id": "P51462" }, { "db_name": "UniProt", "db_id": "Q02815" }, { "db_name": "UniProt", "db_id": "Q28933" }, { "db_name": "UniProt", "db_id": "Q68LC0" }, { "db_name": "UniProt", "db_id": "Q6GUL6" }, { "db_name": "UniProt", "db_id": "Q6IVA5" }, { "db_name": "UniProt", "db_id": "Q6JLX1" }, { "db_name": "UniProt", "db_id": "Q95222" } ] }, { "id": "DS.d1232.s0.e1", "type": "compound", "text": [ "wortmannin" ], "offsets": [ [ 59, 69 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "312145" } ] } ]
[]
[]
[]
DS.d1233
18801905
[ { "id": "DS.d1233.s0", "type": "", "text": [ "After 7 d central leptin treatment, the total content of ceramides was analyzed by quantitative shotgun lipidomics mass spectrometry." ], "offsets": [ [ 0, 133 ] ] } ]
[ { "id": "DS.d1233.s0.e0", "type": "protein", "text": [ "leptin" ], "offsets": [ [ 18, 24 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02750" }, { "db_name": "UniProt", "db_id": "O93416" }, { "db_name": "UniProt", "db_id": "Q28603" }, { "db_name": "UniProt", "db_id": "Q95189" }, { "db_name": "UniProt", "db_id": "Q95234" } ] }, { "id": "DS.d1233.s0.e1", "type": "compound", "text": [ "ceramides" ], "offsets": [ [ 57, 66 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5283565" } ] } ]
[]
[]
[]
DS.d1234
18801908
[ { "id": "DS.d1234.s0", "type": "", "text": [ "Previously we have shown that rosiglitazone has antiinflammatory actions not explicable by activation of PPARgamma,but possibly by the glucocorticoid receptor (GR)." ], "offsets": [ [ 0, 164 ] ] }, { "id": "DS.d1234.s1", "type": "", "text": [ "Rosiglitazone drives luciferase expression from a simple glucocorticoid-response element containing reporter gene in a GR-dependent manner (EC50 4 microm), with a similar amplitude response to the partial GR agonist RU486." ], "offsets": [ [ 165, 387 ] ] } ]
[ { "id": "DS.d1234.s0.e0", "type": "compound", "text": [ "rosiglitazone" ], "offsets": [ [ 30, 43 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "77999" } ] }, { "id": "DS.d1234.s0.e1", "type": "protein", "text": [ "PPARgamma" ], "offsets": [ [ 105, 114 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18924" }, { "db_name": "UniProt", "db_id": "O18971" }, { "db_name": "UniProt", "db_id": "O19052" }, { "db_name": "UniProt", "db_id": "O62807" }, { "db_name": "UniProt", "db_id": "O88275" }, { "db_name": "UniProt", "db_id": "P37231" }, { "db_name": "UniProt", "db_id": "P37234" }, { "db_name": "UniProt", "db_id": "P37238" }, { "db_name": "UniProt", "db_id": "P57797" }, { "db_name": "UniProt", "db_id": "Q4U3Q4" } ] }, { "id": "DS.d1234.s0.e2", "type": "protein", "text": [ "glucocorticoid receptor" ], "offsets": [ [ 135, 158 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O13186" }, { "db_name": "UniProt", "db_id": "O46567" }, { "db_name": "UniProt", "db_id": "O73673" }, { "db_name": "UniProt", "db_id": "P04150" }, { "db_name": "UniProt", "db_id": "P06536" }, { "db_name": "UniProt", "db_id": "P06537" }, { "db_name": "UniProt", "db_id": "P35547" }, { "db_name": "UniProt", "db_id": "P49115" }, { "db_name": "UniProt", "db_id": "P49843" }, { "db_name": "UniProt", "db_id": "P49844" }, { "db_name": "UniProt", "db_id": "P59667" }, { "db_name": "UniProt", "db_id": "P79269" }, { "db_name": "UniProt", "db_id": "P79686" }, { "db_name": "UniProt", "db_id": "Q5R9P5" }, { "db_name": "UniProt", "db_id": "Q6XLJ0" }, { "db_name": "UniProt", "db_id": "Q95267" }, { "db_name": "UniProt", "db_id": "Q9N1U3" } ] }, { "id": "DS.d1234.s1.e0", "type": "compound", "text": [ "Rosiglitazone" ], "offsets": [ [ 165, 178 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "77999" } ] }, { "id": "DS.d1234.s1.e1", "type": "protein", "text": [ "luciferase" ], "offsets": [ [ 186, 196 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08659" }, { "db_name": "UniProt", "db_id": "P13129" }, { "db_name": "UniProt", "db_id": "Q01158" }, { "db_name": "UniProt", "db_id": "Q26304" }, { "db_name": "UniProt", "db_id": "Q27757" } ] } ]
[]
[]
[ { "id": "DS.d1234.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1234.s0.e0", "arg2_id": "DS.d1234.s0.e2", "normalized": [] }, { "id": "DS.d1234.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1234.s1.e0", "arg2_id": "DS.d1234.s1.e1", "normalized": [] } ]
DS.d1235
18801909
[ { "id": "DS.d1235.s0", "type": "", "text": [ "To begin to understand the mechanisms for the development of acute insulin resistance, serine phosphorylation of insulin receptor substrate (IRS)-1 and c-Jun N-terminal kinase phosphorylation/activation was investigated." ], "offsets": [ [ 0, 220 ] ] } ]
[ { "id": "DS.d1235.s0.e0", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 67, 74 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1235.s0.e1", "type": "compound", "text": [ "serine" ], "offsets": [ [ 87, 93 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5951" } ] }, { "id": "DS.d1235.s0.e3", "type": "protein", "text": [ "IRS" ], "offsets": [ [ 141, 144 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P41252" }, { "db_name": "UniProt", "db_id": "Q8BU30" }, { "db_name": "UniProt", "db_id": "Q9XTN2" } ] }, { "id": "DS.d1235.s0.e4", "type": "protein", "text": [ "Jun" ], "offsets": [ [ 154, 157 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05627" }, { "db_name": "UniProt", "db_id": "P17325" }, { "db_name": "UniProt", "db_id": "P18289" } ] } ]
[]
[]
[ { "id": "DS.d1235.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1235.s0.e1", "arg2_id": "DS.d1235.s0.e3", "normalized": [] } ]
DS.d1236
18802196
[ { "id": "DS.d1236.s0", "type": "", "text": [ "Circulating oxidized LDL (oxLDL) levels are strongly correlated to LDL-cholesterol (LDL-c) and apolipoprotein-B100 (apoB100), making it difficult to disentangle their independent contributions to cardiovascular risk." ], "offsets": [ [ 0, 216 ] ] }, { "id": "DS.d1236.s1", "type": "", "text": [ "FMD of the brachial artery and plasma concentrations of oxLDL, LDL-cholesterol, and apoB100 were measured in 624 men and women (age range 50 to 87 years), participating in a population-based cohort study." ], "offsets": [ [ 217, 421 ] ] }, { "id": "DS.d1236.s2", "type": "", "text": [ "After adjustment for age, sex, glucose tolerance status, and Framingham risk score, the oxLDL/apoB100 ratio was negatively related to FMD (P = 0.017)." ], "offsets": [ [ 422, 572 ] ] } ]
[ { "id": "DS.d1236.s0.e0", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 71, 82 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d1236.s0.e1", "type": "protein", "text": [ "apoB100" ], "offsets": [ [ 116, 123 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04114" } ] }, { "id": "DS.d1236.s1.e0", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 284, 295 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d1236.s1.e1", "type": "protein", "text": [ "apoB100" ], "offsets": [ [ 301, 308 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04114" } ] }, { "id": "DS.d1236.s2.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 453, 460 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1236.s2.e1", "type": "protein", "text": [ "apoB100" ], "offsets": [ [ 516, 523 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04114" } ] } ]
[]
[]
[]
DS.d1237
18802325
[ { "id": "DS.d1237.s0", "type": "", "text": [ "The fibrillin-1 isolated from the youngest group had the highest capacity to form fructosamine and AGEs under glycation in vitro." ], "offsets": [ [ 0, 129 ] ] } ]
[ { "id": "DS.d1237.s0.e0", "type": "protein", "text": [ "fibrillin-1" ], "offsets": [ [ 4, 15 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O81439" } ] }, { "id": "DS.d1237.s0.e1", "type": "compound", "text": [ "fructosamine" ], "offsets": [ [ 82, 94 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "20484" } ] } ]
[]
[]
[ { "id": "DS.d1237.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1237.s0.e1", "arg2_id": "DS.d1237.s0.e0", "normalized": [] } ]
DS.d1238
18802724
[ { "id": "DS.d1238.s0", "type": "", "text": [ "The patterns of nerves immunoreactive (IR) to antibodies towards serotonin (5-HT) and the invertebrate neuropeptide FMRFamide are described in relation to the musculature." ], "offsets": [ [ 0, 171 ] ] } ]
[ { "id": "DS.d1238.s0.e0", "type": "compound", "text": [ "serotonin" ], "offsets": [ [ 65, 74 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5202" } ] }, { "id": "DS.d1238.s0.e1", "type": "compound", "text": [ "5-HT" ], "offsets": [ [ 76, 80 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5202" } ] }, { "id": "DS.d1238.s0.e2", "type": "protein", "text": [ "neuropeptide" ], "offsets": [ [ 103, 115 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21259" } ] }, { "id": "DS.d1238.s0.e3", "type": "protein", "text": [ "FMRFamide" ], "offsets": [ [ 116, 125 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08020" }, { "db_name": "UniProt", "db_id": "P08021" }, { "db_name": "UniProt", "db_id": "P08022" }, { "db_name": "UniProt", "db_id": "P69145" }, { "db_name": "UniProt", "db_id": "P69146" }, { "db_name": "UniProt", "db_id": "P69147" }, { "db_name": "UniProt", "db_id": "P69148" } ] } ]
[]
[]
[]
DS.d1239
18802750
[ { "id": "DS.d1239.s0", "type": "", "text": [ "Based on these results we analyzed the expression of either M1 receptors or BDNF following PMA treatment of retinal cell cultures." ], "offsets": [ [ 0, 130 ] ] } ]
[ { "id": "DS.d1239.s0.e0", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 76, 80 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] }, { "id": "DS.d1239.s0.e1", "type": "compound", "text": [ "PMA" ], "offsets": [ [ 91, 94 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "27924" }, { "db_name": "PubChem", "db_id": "122634" }, { "db_name": "PubChem", "db_id": "22833501" } ] } ]
[]
[]
[]
DS.d1240
18802816
[ { "id": "DS.d1240.s0", "type": "", "text": [ "Immunotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate and the role of peroxisome proliferator-activated receptor alpha." ], "offsets": [ [ 0, 136 ] ] } ]
[ { "id": "DS.d1240.s0.e0", "type": "compound", "text": [ "sulfonate" ], "offsets": [ [ 61, 70 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1099" } ] }, { "id": "DS.d1240.s0.e1", "type": "protein", "text": [ "peroxisome proliferator-activated receptor alpha" ], "offsets": [ [ 87, 135 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35507" }, { "db_name": "UniProt", "db_id": "P23204" }, { "db_name": "UniProt", "db_id": "P37230" }, { "db_name": "UniProt", "db_id": "P37232" }, { "db_name": "UniProt", "db_id": "Q07869" }, { "db_name": "UniProt", "db_id": "Q8HYL6" }, { "db_name": "UniProt", "db_id": "Q95N78" } ] } ]
[]
[]
[]
DS.d1241
18803227
[ { "id": "DS.d1241.s0", "type": "", "text": [ "Inhibitory activities of Cassia tora and its anthraquinone constituents on angiotensin-converting enzyme." ], "offsets": [ [ 0, 105 ] ] } ]
[ { "id": "DS.d1241.s0.e0", "type": "compound", "text": [ "anthraquinone" ], "offsets": [ [ 45, 58 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6780" } ] }, { "id": "DS.d1241.s0.e1", "type": "protein", "text": [ "angiotensin-converting enzyme" ], "offsets": [ [ 75, 104 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q10751" } ] } ]
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[ { "id": "DS.d1241.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1241.s0.e0", "arg2_id": "DS.d1241.s0.e1", "normalized": [] } ]
DS.d1242
18803284
[ { "id": "DS.d1242.s0", "type": "", "text": [ "The results obtained from the Fluo-3 image experiments showed that VEGF pretreatment of cultured neurons at a final concentration of 50, 100, or 200 ng/ml acutely and dose dependently attenuated the Ca(2+) influx induced by application of KCl (60 mM) or glutamate (50 microM)." ], "offsets": [ [ 0, 276 ] ] } ]
[ { "id": "DS.d1242.s0.e0", "type": "compound", "text": [ "Fluo-3" ], "offsets": [ [ 30, 36 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104978" } ] }, { "id": "DS.d1242.s0.e1", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 67, 71 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d1242.s0.e2", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 199, 203 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] } ]
[]
[]
[ { "id": "DS.d1242.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1242.s0.e2", "arg2_id": "DS.d1242.s0.e1", "normalized": [] } ]
DS.d1243
18803286
[ { "id": "DS.d1243.s0", "type": "", "text": [ "5-Bromo-2'-deoxyuridine (BrdU) was injected into pregnant mice 3 hr after the NT3 administration to label the neural progenitor cells." ], "offsets": [ [ 0, 134 ] ] } ]
[ { "id": "DS.d1243.s0.e0", "type": "compound", "text": [ "5-Bromo-2'-deoxyuridine (BrdU" ], "offsets": [ [ 0, 29 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6035" } ] }, { "id": "DS.d1243.s0.e1", "type": "protein", "text": [ "NT3" ], "offsets": [ [ 78, 81 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P59275" }, { "db_name": "UniProt", "db_id": "P80958" }, { "db_name": "UniProt", "db_id": "Q99523" } ] } ]
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[]
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