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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nevertheless, caution is indicated in the co-administration of TCAs with any of the SSRIs and also in switching from one class to the other. | <TCAs, advise, SSRIs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Inhibitors or substrates of CYP2D6 (i.e., quinidine, selective serotonin reuptake inhibitors [SSRIs]) may increase the plasma concentration of doxepin when administered concomitantly. | <quinidine, mechanism, doxepin>, <selective serotonin reuptake inhibitors, mechanism, doxepin>, <SSRIs, mechanism, doxepin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, MAO inhibitors should be discontinued at least two weeks prior to the cautious initiation of therapy with SINEQUAN. | <MAO inhibitors, advise, SINEQUAN> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cimetidine: Cimetidine has been reported to produce clinically significant fluctuations in steady-state serum concentrations of various tricyclic antidepressants. | <Cimetidine, mechanism, tricyclic antidepressants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Serious anticholinergic symptoms (i.e., severe dry mouth, urinary retention and blurred vision) have been associated with elevations in the serum levels of tricyclic antidepressant when cimetidine therapy is initiated. | <tricyclic antidepressant, effect, cimetidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Additionally, higher than expected tricyclic antidepressant levels have been observed when they are begun in patients already taking cimetidine. | <tricyclic antidepressant, mechanism, cimetidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In patients who have been reported to be well controlled on tricyclic antidepressants receiving concurrent cimetidine therapy, discontinuation of cimetidine has been reported to decrease established steady-state serum tricyclic antidepressant levels and compromise their therapeutic effects. | <cimetidine, mechanism, tricyclic antidepressant> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Alcohol: It should be borne in mind that alcohol ingestion may increase the danger inherent in any intentional or unintentional SINEQUAN overdosage. | <alcohol, mechanism, SINEQUAN> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Tolazamide: A case of severe hypoglycemia has been reported in a type II diabetic patient maintained on tolazamide (1 gm/day) 11 days after the addition of doxepin (75 mg/day). | <tolazamide, effect, doxepin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Prolonged recovery time may occur if barbiturates and/or narcotics are used concurrently with ketamine. | <barbiturates, effect, ketamine>, <narcotics, effect, ketamine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Isocarboxazid should be administered with caution to patients receiving Antabuse (disulfiram, Wyeth-Ayerst Laboratories). | <Isocarboxazid, advise, Antabuse>, <Isocarboxazid, advise, disulfiram> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In a single study, rats given high intraperitoneal doses of an MAO inhibitor plus disulfiram experienced severe toxicity, including convulsions and death. | <MAO inhibitor, effect, disulfiram> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concomitant use of Isocarboxazid and other psychotropic agents is generally not recommended because of possible potentiating effects. | <Isocarboxazid, advise, psychotropic agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Anesthetics/Sedatives/Hypnotics/Opioids: Co-administration of PRECEDEX with anesthetics, sedatives, hypnotics, and opioids is likely to lead to an enhancement of effects. | <PRECEDEX, effect, anesthetics>, <PRECEDEX, effect, sedatives>, <PRECEDEX, effect, hypnotics>, <PRECEDEX, effect, opioids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, due to possible pharmacodynamic interactions, when co-administered with PRECEDEX, a reduction in dosage of PRECEDEX on the concomitant anesthetic, sedative, hypnotic or opioid may be required. | <PRECEDEX, advise, anesthetic>, <PRECEDEX, advise, sedative>, <PRECEDEX, advise, hypnotic>, <PRECEDEX, advise, opioid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Caution is advised in patients receiving concomitant high-dose aspirin and carbonic anhydrase inhibitors, as anorexia, tachypnea, lethargy and coma have been rarely reported due to a possible drug interaction. | <aspirin, advise, carbonic anhydrase inhibitors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Digoxin and verapamil use may be rarely associated with ventricular fibrillation when combined with Adenocard. | <Digoxin, effect, Adenocard>, <verapamil, effect, Adenocard> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The use of Adenocard in patients receiving digitalis may be rarely associated with ventricular fibrillation. | <Adenocard, effect, digitalis> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The effects of adenosine are antagonized by methylxanthines such as caffeine and theophylline. | <adenosine, effect, methylxanthines>, <adenosine, effect, caffeine>, <adenosine, effect, theophylline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In the presence of these methylxanthines, larger doses of adenosine may be required or adenosine may not be effective. | <methylxanthines, advise, adenosine>, <methylxanthines, advise, adenosine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Adenosine effects are potentiated by dipyridamole. | <Adenosine, effect, dipyridamole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Thus, smaller doses of adenosine may be effective in the presence of dipyridamole. | <adenosine, effect, dipyridamole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | As the primary effect of adenosine is to decrease conduction through the A-V node, higher degrees of heart block may be produced in the presence of carbamazepine. | <adenosine, effect, carbamazepine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cimetidine: In a study in healthy volunteers, a one-week course of cimetidine at 400 mg b.i.d. with a single 5 mg dose of isradipine on the sixth day showed an increase in isradipine mean peak plasma concentrations (36%) and significant increase in area under the curve (50%). | <cimetidine, mechanism, isradipine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If isradipine therapy is initiated in a patient currently receiving cimetidine careful monitoring for adverse reactions is advised and downward dose adjustment may be required. | <isradipine, advise, cimetidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Rifampicin: In a study in healthy volunteers, a six-day course of rifampicin at 600 mg/day followed by a single 5 mg dose of isradipine resulted in a reduction in isradipine levels to below detectable limits. | <rifampicin, mechanism, isradipine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If rifampicin therapy is required, isradipine concentrations and therapeutic effects are likely to be markedly reduced or abolished as a consequence of increased metabolism and higher clearance of isradipine. | <rifampicin, mechanism, isradipine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Fentanyl Anesthesia: Severe hypotension has been reported during fentanyl anesthesia with concomitant use of a beta blocker and a calcium channel blocker. | <fentanyl, effect, beta blocker>, <fentanyl, effect, calcium channel blocker> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Drugs which induce CYP3A4 activity (eg, phenobarbital, rifampin, rifabutin) would be expected to increase the clearance of efavirenz resulting in lowered plasma concentrations. | <phenobarbital, mechanism, efavirenz>, <rifampin, mechanism, efavirenz>, <rifabutin, mechanism, efavirenz> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In uninfected volunteers, 46% developed rash while receiving SUSTIVA and clarithromycin. | <SUSTIVA, effect, clarithromycin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Increasing the indinavir dose to 1000 mg every 8 hours does not compensate for the increased indinavir metabolism due to SUSTIVA. | <indinavir, mechanism, SUSTIVA> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When indinavir at an increased dose (1000 mg every 8 hours) was given with SUSTIVA (600 mg once daily), the indinavir AUC and Cmin were decreased on average by 33-46% and 39-57%, respectively, compared to when indinavir (800 mg every 8 hours) was given alone. | <indinavir, mechanism, SUSTIVA> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | A dose increase of lopinavir/ritonavir to 533/133 mg (4 capsules or 6.5 mL) twice daily taken with food is recommended when used in combination with SUSTIVA. | <lopinavir, advise, SUSTIVA>, <ritonavir, advise, SUSTIVA> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Because the potential interaction of efavirenz with oral contraceptives has not been fully characterized, a reliable method of barrier contraception should be used in addition to oral contraceptives. | <efavirenz, advise, contraceptives> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Monitoring of liver enzymes is recommended when SUSTIVA is used in combination with ritonavir. | <SUSTIVA, advise, ritonavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Potential for reduction in anticonvulsant and/or efavirenz plasma levels; | <anticonvulsant, mechanism, efavirenz> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | SUSTIVA has the potential to decrease plasma concentrations of itraconazole and ketoconazole. | <SUSTIVA, mechanism, itraconazole>, <SUSTIVA, mechanism, ketoconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Indinavir steady-state Cmax, A.C. and Cmin were decreased by 22%, 38%, and 27%, respectively, by concomitant amprenavir. | <Indinavir, mechanism, amprenavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Saquinavir steady-state Cmax, A.C. and Cmin were increased 21%, decreased 19%, and decreased 48%, respectively, by concomitant amprenavir. | <Saquinavir, mechanism, amprenavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nelfinavir steady-state Cmax, A.C. and Cmin were increased by 12%, 15%, and 14%, respectively, by concomitant amprenavir. | <Nelfinavir, mechanism, amprenavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Methadone: Coadministration of amprenavir and methadone can decrease plasma levels of methadone. | <amprenavir, effect, methadone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coadministration of amprenavir and methadone as compared to a non-matched historicalcontrol group resulted in a 30%, 27%, and 25% decrease in serum amprenavir AUC, Cmax, andCmin, respectively. | <amprenavir, mechanism, methadone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Laboratory Tests: The combination of Amprenavir and low-dose ritonavir has been associated with elevations of cholesterol and triglycerides, SGOT (AST), and SGPT (ALT) in some patients. | <Amprenavir, effect, ritonavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Appropriate laboratory testing should be considered prior to initiating combination therapy with Amprenavir and ritonavir and at periodic intervals or if any clinical signs or symptoms of hyperlipidemia or elevated liver function tests occur during therapy. | <Amprenavir, advise, ritonavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Corticotropin may accentuate the electrolyte loss associated with diuretic therapy. | <Corticotropin, effect, diuretic> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Beta-adrenergic Blocking Agents: Experience in over 1400 patients in a non-comparative clinical trial has shown that concomitant administration of nifedipine and beta-blocking agents is usually well tolerated, but there have been occasional literature reports suggesting that the combination may increase the likelihood of congestive heart failure, severe hypotension or exacerbation of angina. | <nifedipine, effect, beta-blocking agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Digitalis: Immediate Release Capsules: Since there have been isolated reports of patients with elevated digoxin levels, and there is a possible interaction between digoxin and nifedipine, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over- or under-digitalization. | <digoxin, int, nifedipine>, <digoxin, advise, nifedipine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Extended Release Tablets: Administration of nifedipine with digoxin increased digoxin levels in 9 of 12 normal volunteers. | <digoxin, mechanism, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Since there have been isolated reports of patients with elevated digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over- or under-digitalization. | <digoxin, advise, nifedipine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Quinidine: Immediate Release Capsules: There have been rare reports of an interaction between quinidine and nifedipine (with a decreased plasma level of quinidine). | <quinidine, mechanism, nifedipine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coumarin Anticoagulants: There have been rare reports of increased prothrombin time in patients taking coumarin anticoagulants to whom nifedipine was administered. | <coumarin anticoagulants, effect, nifedipine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cimetidine: A study in 6 healthy volunteers has shown a significant increase in peak nifedipine plasma levels (80%) and area-under-the-curve (74%) after a 1 week course of cimetidine at 1000 mg per day and nifedipine at 40 mg per day. | <cimetidine, mechanism, nifedipine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If nifedipine therapy is initiated in a patient currently receiving cimetidine, cautious titration is advised. | <nifedipine, advise, cimetidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Interactions for vitamin D analogues (Vitamin D2, Vitamin D3, Calcitriol, and Calcidiol): Cholestyramine: Cholestyramine has been reported to reduce intestinal absorption of fat soluble vitamins; | <Cholestyramine, mechanism, fat soluble vitamins> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Some reports have shown that the concomitant administration of thiazides with vitamin D causes hypercalcemia. | <thiazides, effect, vitamin D> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Digitalis: Vitamin D dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias. | <Vitamin D, advise, digitalis> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ketoconazole: Ketoconazole may inhibit both synthetic and catabolic enzymes of vitamin D. | <Ketoconazole, mechanism, vitamin D> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Corticosteroids: A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. | <vitamin D, effect, corticosteroids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Magnesium: Magnesium-containing preparations (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with vitamin D by patients on chronic renal dialysis. | <Magnesium, effect, vitamin D>, <antacids, effect, vitamin D> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In normal volunteers receiving indomethacin, the administration of diflunisal decreased the renal clearance and significantly increased the plasma levels of indomethacin. | <diflunisal, mechanism, indomethacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In some patients, combined use of INDOCIN and diflunisal has been associated with fatal gastrointestinal hemorrhage. | <INDOCIN, effect, diflunisal> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, diflunisal and INDOCIN should not be used concomitantly. | <diflunisal, advise, INDOCIN> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In a study in normal volunteers, it was found that chronic concurrent administration of 3.6 g of aspirin per day decreases indomethacin blood levels approximately 20%. | <aspirin, mechanism, indomethacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The concomitant use of INDOCIN with other NSAIDs is not recommended due to the increased possibility of gastrointestinal toxicity, with little or no increase in efficacy. | <INDOCIN, advise, NSAIDs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, when any additional drug, including INDOCIN, is added to the treatment of patients on anticoagulant therapy, the patients should be observed for alterations of the prothrombin time. | <INDOCIN, advise, anticoagulant> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In post-marketing experience, bleeding has been reported in patients on concomitant treatment with anticoagulants and INDOCIN. | <anticoagulants, effect, INDOCIN> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Caution should be exercised when INDOCIN and anticoagulants are administered concomitantly. | <INDOCIN, advise, anticoagulants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When INDOCIN is given to patients receiving probenecid, the plasma levels of indomethacin are likely to be increased. | <INDOCIN, mechanism, probenecid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Caution should be used if INDOCIN is administered simultaneously with methotrexate. | <INDOCIN, advise, methotrexate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | INDOCIN has been reported to decrease the tubular secretion of methotrexate and to potentiate its toxicity. | <INDOCIN, mechanism, methotrexate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Administration of non-steroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity, possibly due to decreased synthesis of renal prostacyclin. | <non-steroidal anti-inflammatory drugs, effect, cyclosporine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | NSAIDs should be used with caution in patients taking cyclosporine, and renal function should be carefully monitored. | <NSAIDs, advise, cyclosporine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Capsules INDOCIN 50 mg t.i.d. produced a clinically relevant elevation of plasma lithium and reduction in renal lithium clearance in psychiatric patients and normal subjects with steady state plasma lithium concentrations. | <INDOCIN, mechanism, lithium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | As a consequence, when INDOCIN and lithium are given concomitantly, the patient should be carefully observed for signs of lithium toxicity. | <INDOCIN, advise, lithium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | INDOCIN given concomitantly with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin. | <INDOCIN, mechanism, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, when INDOCIN and digoxin are used concomitantly, serum digoxin levels should be closely monitored. | <INDOCIN, advise, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In some patients, the administration of INDOCIN can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. | <INDOCIN, effect, loop diuretics>, <INDOCIN, effect, potassium-sparing diuretics>, <INDOCIN, effect, thiazide diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It has been reported that the addition of triamterene to a maintenance schedule of INDOCIN resulted in reversible acute renal failure in two of four healthy volunteers. | <triamterene, effect, INDOCIN> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | INDOCIN and triamterene should not be administered together. | <INDOCIN, advise, triamterene> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The potential effects of INDOCIN and potassium-sparing diuretics on potassium kinetics and renal function should be considered when these agents are administered concurrently. | <INDOCIN, effect, potassium-sparing diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Most of the above effects concerning diuretics have been attributed, at least in part, to mechanisms involving inhibition of prostaglandin synthesis by INDOCIN. | <diuretics, effect, INDOCIN> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by non-steroidal antiinflammatory drugs including INDOCIN has been reported. | <beta-adrenoceptor blocking agents, effect, non-steroidal antiinflammatory drugs>, <beta-adrenoceptor blocking agents, effect, INDOCIN> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | INDOCIN can reduce the antihypertensive effects of captopril and losartan. | <INDOCIN, effect, captopril>, <INDOCIN, effect, losartan> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Based on clinical and pharmacokinetic results from the ATAC trial, tamoxifen should not be administered with anastrozole (see CLINICAL PHARMACOLOGY Drug Interactions and CLINICAL PHARMACOLOGY - Clinical Studies - Adjuvant Treatment of Breast Cancer in Postmenopausal Women subsections). | <tamoxifen, advise, anastrozole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Co-administration of anastrozole and tamoxifen resulted in a reduction of anastrozole plasma levels by 27% compared with those achieved with anastrozole alone. | <anastrozole, mechanism, tamoxifen> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Estrogen-containing therapies should not be used with ARIMIDEX as they may diminish its pharmacologic action. | <Estrogen, advise, ARIMIDEX> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Chlorthalidone may add to or potentiate the action of other antihypertensive drugs. | <Chlorthalidone, effect, antihypertensive drugs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Chlorthalidone and related drugs may increase the responsiveness to tubocurarine. | <Chlorthalidone, effect, tubocurarine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Chlorthalidone and related drugs may decrease arterial responsiveness to norepinephrine. | <Chlorthalidone, effect, norepinephrine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In another drug interaction study, co-administration of orally inhaled ciclesonide and oral ketoconazole, a potent inhibitor of cytochrome P450 3A4, increased the exposure (AUC) of des-ciclesonide by approximately 3.6-fold at steady state, while levels of ciclesonide remained unchanged. | <ciclesonide, mechanism, ketoconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, ketoconazole should be administered with caution with intranasal ciclesonide. | <ketoconazole, advise, ciclesonide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If you are also using a steroid inhaler, take bitolterol first and then wait about 15 minutes before using the steroid inhaler. | <steroid, advise, bitolterol>, <bitolterol, advise, steroid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | This allows bitolterol to open air passages, increasing the effectiveness of the steroid. | <bitolterol, effect, steroid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Hypotension Patients on Diuretic Therapy: Patients on diuretics and especially those in whom diuretic therapy was recently instituted, as well as those on severe dietary salt restriction or dialysis, may occasionally experience a precipitous reduction of blood pressure usually within the first hour after receiving the initial dose of captopril. | <diuretics, effect, captopril> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The possibility of hypotensive effects with captopril can be minimized by either discontinuing the diuretic or increasing the salt intake approximately one week prior to initiation of treatment with captopril (captopril tablets, USP) or initiating therapy with small doses (6.25 or 12.5 mg). | <captopril, effect, diuretic> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | therefore, nitroglycerin or other nitrates (as used for management of angina) or other drugs having vasodilator activity should, if possible, be discontinued before starting captopril. | <nitroglycerin, advise, captopril>, <nitrates, advise, captopril> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Agents Causing Renin Release Captopril's effect will be augmented by antihypertensive agents that cause renin release. | <Captopril, effect, antihypertensive agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Beta-adrenergic blocking drugs add some further antihypertensive effect to captopril, but the overall response is less than additive. | <Beta-adrenergic blocking drugs, effect, captopril> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Inhibitors Of Endogenous Prostaglandin Synthesis It has been reported that indomethacin may reduce the antihypertensive effect of captopril, especially in cases of low renin hypertension. | <indomethacin, effect, captopril> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Lithium: Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy. | <lithium, effect, ACE inhibitor> |