qiuxi337/gemma-3-12b-bnb-grpo

Gemma-3-12B-GRPO trained with GRPO via 4-bit PEFT

Due to limited available computational resources, we randomly sampled 500 data points from MedQA-USMLE using a methodology and conducted preliminary GRPO experiments under 4-bit quantization conditions (Q-LoRA) using the Unsloth framework. We are now releasing this as a preview version. More experiments and explorations are currently underway, and a technical report is in preparation. Thank you for your patience. We conduct the experiments on one RTX-4090 (24GB VRAM).

Evaluation Results

The model is evaluated on four benchmark datasets: MMLU, MMLU-Pro, CMMU, and GSM8K. The experimental results are summarized in Table 1, with comprehensive analyses provided in the Detailed Results section.

Tab.1 Evaluation results.

Dataset	Gemma-3-12b-it	Gemma3-12b-GRPO
MMLU	66.90	66.78
MMLU-Pro	56.15	56.20
CMMLU	47.50	46.99
GSM8K	92.19	92.95

Requirements

pip install torch==2.6.0 torchaudio==2.6.0 torchvision==0.21.0 -i --index-url https://download.pytorch.org/whl/cu124
pip install transformer vllm bitsandbytes peft
pip install flash-attn --no-build-isolation

Run with vLLM

The following code contains the script for running with vLLM. We have added comments to indicate optional parameters; please remove these comments before executing the script.

vllm serve google/gemma-3-12b-it \
     --qlora-adapter-name-or-path gemma-3-12b-bnb-grpo \ #if you download the weights and put it in this directory
     --quantization bitsandbytes \
     --enable-lora \
     --max-lora-rank 128 \
     --load-format bitsandbytes \
     --gpu-memory-utilization 0.85 \
     --max-model-len 4096 #You can change it \
     --served-model-name gemma3-12b-grpo #optional, you can change it to your prefer name \
     --api-key your_api_key #optionnal, you can input your key

You can use the following script to run with vLLM.

huggingface-cli download qiuxi337/gemma-3-12b-bnb-grpo --local-dir gemma-3-12b-bnb-grpo
vllm serve google/gemma-3-12b-it \
     --qlora-adapter-name-or-path gemma-3-12b-bnb-grpo \
     --quantization bitsandbytes \
     --enable-lora \
     --max-lora-rank 128 \
     --load-format bitsandbytes \
     --gpu-memory-utilization 0.85 \
     --max-model-len 4096 \
     --served-model-name gemma3-12b-grpo \
     --api-key your_api_key

Example

• Example 1: From the baichuan-m1-14b Technical Report

user：

A 24-year-old female patient started to experience involuntary tremors in both thumbs half a year ago. The tremors gradually progressed to involve both hands and were more obvious during movement. The symptoms gradually worsened, accompanied by tremors in both lower limbs and unsteady walking. She gradually developed mild speech difficulties, slurred speech, choking during swallowing, as well as personality changes, with obvious mood swings and irritability. Laboratory tests indicated abnormal liver function, abnormal kidney function, low white blood cell count, and a significantly decreased ceruloplasmin. Head MRI showed multiple abnormal signal changes in the bilateral basal ganglia, thalamus, midbrain, and pons, along with demyelination in the white matter of the left frontal lobe. Regarding the pathogenesis of the patient’s neurological symptoms in this case, which of the following most accurately describes its pathological process?
A. Immune - mediated central nervous system demyelination
B. Abnormal accumulation of copper ions in the basal ganglia and other brain regions,
generating a large number of free radicals leading to neuronal damage
C. Gene mutations cause abnormal myelin proteins, resulting in widespread central nervous
system demyelination
D. Cerebral microvascular lesions lead to repeated small - area infarctions, causing nerve
function impairment
E. Deposition of iron ions in the brain, triggering oxidative stress and nerve damage

Response:

<think>Okay, let's break down this case and determine the most likely pathological process. The patient presents with a constellation of neurological symptoms: tremors, unsteady walking, slurred speech, swallowing difficulties, personality changes, and crucially, abnormal lab results including low ceruloplasmin and abnormal liver/kidney function. The MRI findings of lesions in the basal ganglia, thalamus, midbrain, pons, and white matter further inform our diagnosis.

Let's analyze each option:

A. Immune-mediated central nervous system demyelination: While demyelination is present (seen in the MRI), the other symptoms and lab findings don't strongly support an autoimmune etiology. Autoimmune demyelination typically presents with more acute and relapsing-remitting symptoms. The slow progression and systemic involvement (liver, kidney, ceruloplasmin) are not typical.

B. Abnormal accumulation of copper ions in the basal ganglia and other brain regions, generating a large number of free radicals leading to neuronal damage: This aligns very well with the clinical picture. Low ceruloplasmin, a copper-carrying protein, strongly suggests impaired copper metabolism. Copper accumulation in the brain, as indicated by the basal ganglia lesions on MRI, would lead to oxidative stress and neuronal damage, explaining the tremors, movement disorders, and cognitive/personality changes. The liver and kidney involvement are also consistent with copper metabolism issues.

C. Gene mutations cause abnormal myelin proteins, resulting in widespread central nervous system demyelination: This is possible, but less likely than option B given the low ceruloplasmin. It doesn’t explain the systemic involvement.

D. Cerebral microvascular lesions lead to repeated small-area infarctions, causing nerve function impairment: While microvascular disease is a possibility, it doesn't readily explain the low ceruloplasmin or the specific distribution of lesions (basal ganglia, thalamus, midbrain, pons). Infarcts are also generally more acute.

E. Deposition of iron ions in the brain, triggering oxidative stress and nerve damage: While iron deposition can cause oxidative stress, it’s not the primary explanation for the combination of symptoms and the key lab finding of low ceruloplasmin.

Therefore, the most accurate answer is B.</think>
<answer>B. Abnormal accumulation of copper ions in the basal ganglia and other brain regions, generating a large number of free radicals leading to neuronal damage</answer>

Note: This answer is same to the baichuan-m1-14b.

• Example 2: From Baichuan-M1-14B Technical Report

User:

Which surgical procedure is most appropriate for treating an aneurysm in the lower part of the thoracic aorta using an invasive method?
    A. Endovascular aneurysm repair (EVAR)
    B. Thoracic endovascular aortic repair (TEVAR)
    C. Open surgical repair of descending thoracic aortic aneurysm
    D. Hybrid aortic arch repair
    E. Aortic valve replacement with ascending aorta graft

Response:

<think>The question asks about the *most appropriate* surgical procedure for treating an aneurysm in the *lower* part of the thoracic aorta using an *invasive* method. Let's break down the options:

*   **A. Endovascular aneurysm repair (EVAR):** This is a minimally invasive procedure, not invasive as requested.
*   **B. Thoracic endovascular aortic repair (TEVAR):** This is an endovascular approach, meaning it's minimally invasive. This isn't the invasive method requested.
*   **C. Open surgical repair of descending thoracic aortic aneurysm:** This is a *fully invasive* procedure, requiring an open incision and direct surgical repair. It directly addresses the aneurysm. The location (descending thoracic aorta) also matches the aneurysm's location.
*   **D. Hybrid aortic arch repair:** This combines endovascular and open techniques, but isn't solely an invasive method as requested. It is more complex and typically used for aneurysms involving the aortic arch.
*   **E. Aortic valve replacement with ascending aorta graft:** This is unrelated to the location of the aneurysm (lower thoracic aorta) and focuses on the aortic valve.

Therefore, the most appropriate answer is C, as it's the only truly invasive procedure targeting the specified location. </think>
<answer>C. Open surgical repair of descending thoracic aortic aneurysm</answer>

Note: This answer is same to the baichuan-m1-14b.

• Example 3: From Baichuan-M1-14B Technical Report

User

患者：被沾有病人血液的实心针头扎了，针头是一天前沾的病人血液，还有传染疾病的可能吗（女, 年龄26岁）
医生：请问您是否知道那位病人的具体健康状况或是否患有任何传染性疾病？例如，乙肝、丙肝或艾滋病等？
患者：不知道。
医生：请问您是否接种过乙型肝炎疫苗？
患者：接种过。
医生：请问您被扎到的具体部位是哪里？伤口的深度如何？是否有出血？
患者：大拇指根部，深度大约0.5厘米，出血了。
根据以上信息，若该病人同时患有乙肝、丙肝或艾滋病，
患者最可能感染哪种疾病，并说明理由。

Response:

<think>
The question asks about the most likely disease to be contracted given a needle stick injury with a potentially contaminated needle. The patient has been vaccinated against Hepatitis B. We need to consider the likelihood of contracting Hepatitis B, Hepatitis C, and HIV, given the lack of knowledge about the source patient’s status, and the vaccination status of the injured patient.

*   **Hepatitis B:** The patient has been vaccinated against Hepatitis B. Vaccination provides significant protection, though it's not 100% effective. However, a needlestick still warrants concern, especially if the source patient's status is unknown.
*   **Hepatitis C:** There is no vaccine for Hepatitis C. The risk of transmission through a needlestick is significant (estimated around 7-50% depending on viral load).
*   **HIV:** The risk of HIV transmission through a needlestick is lower than Hepatitis C, but still present (estimated 0.1-3%).

Considering the provided information and the relative risks, even with the Hepatitis B vaccination, the most likely disease to be contracted, given the unknown status of the source patient, is Hepatitis C. This is because the patient is not vaccinated against Hepatitis C, and the transmission rate is relatively high. The fact that there was bleeding from the wound also increases the risk.

</think><answer>
Given the information and assuming the source patient has any of the three diseases (Hepatitis B, Hepatitis C, or HIV), the patient is most likely to contract **Hepatitis C**.

Here's the reasoning:

*   The patient is vaccinated against Hepatitis B, significantly reducing the risk of infection, although not eliminating it entirely.
*   There is no vaccine for Hepatitis C.
*   The risk of Hepatitis C transmission through a needlestick is relatively high (7-50%).
*   The risk of HIV transmission is lower than Hepatitis C (0.1-3%).
*   The presence of bleeding from the wound further elevates the risk of transmission.

Therefore, without knowing the status of the source patient, Hepatitis C poses the greatest potential risk to the patient. It's crucial for the patient to seek immediate medical advice and undergo testing for all three diseases.
</answer>

Note: This answer is same to the baichuan-m1-14b.

• Example 4: From Baichuan-M1-14B Technical Report

User:

一位78岁女性患者，既往诊断为二尖瓣脱垂，来急诊就诊，主诉24小时内出现4次鲜红色便血。体格检查显示脉率120次/分，血压88/58mmHg。应该采取的最佳初步处理措施是什么？只给一个答案。

Response:

<think>Okay, let's break down this case and determine the best initial management.

**Patient Presentation:** 78-year-old female with a history of mitral valve prolapse (MVP) presenting with 24 hours of hematochezia (fresh red blood in stool) and signs of hypovolemic shock (tachycardia and hypotension).  The key here is the acute bleeding and the signs of instability.

**Potential Causes:** While MVP itself doesn't directly *cause* bleeding, it's important to consider associated conditions. The hematochezia suggests a source of bleeding in the lower GI tract. Possible causes include:       

*   Diverticulosis/diverticular bleeding: A common cause of lower GI bleeding, especially in older adults.
*   Angiodysplasia: Abnormal blood vessels in the GI tract that can bleed.
*   Colonic polyps or cancer: Less likely to present with *acute* and massive bleeding, but still needs to be considered.
*   Medications:  Any medications that could increase bleeding risk (anticoagulants, NSAIDs) should be considered, though it's not explicitly stated in the prompt.

**Priorities:** The immediate priority is to address the hypovolemic shock.  Stabilization is paramount before attempting to pinpoint the exact source of the bleeding.

**Possible Actions and Reasoning:**

*   **Fluid Resuscitation:** The patient is hypotensive and tachycardic, indicating significant blood loss.  This is the most critical first step.
*   **Oxygen:** Ensure adequate oxygenation.
*   **Monitoring:** Continuous monitoring of vital signs, including oxygen saturation.
*   **Blood Typing and Crossmatching:**  Prepare for potential transfusion.
*   **Further investigations:** After initial stabilization, investigations like endoscopy or angiography may be needed to locate the bleeding source.

**Why other options are not ideal as the *initial* step:**

*   Colonoscopy: While ultimately necessary to diagnose, it's not the *first* thing to do in an unstable patient. You need to stabilize them first.
*   Angiography: Similar to colonoscopy, this is diagnostic and not immediately lifesaving.
*   Medications:  Addressing the underlying cause is important, but secondary to stabilization.

**Therefore, the best initial step is fluid resuscitation.**</think><answer>Fluid resuscitation</answer>

Note: This answer is same to the baichuan-m1-14b.

• Example5: From Baichuan-M1-14B Technical Report

User:

#一般资料#:性别: 男年龄: 43岁职业: 无
#主诉#:全身黄染、腹胀、尿少、乏力、纳差伴双下肢浮肿半月。
#现病史#:患者半月前出现全身黄染，伴随腹胀、尿少、
纳差，曾在外院接受治疗，治疗内容包括抗病毒、抗感染、
补充白蛋白等，但症状未缓解，反而腹胀加重，出现双下肢浮肿，
因此再次入院。患者自述病后精神、食欲减退，睡眠一般，
小便颜色深黄，量少，大便干结，无黑便。
#既往史#:患者既往乙型肝炎病史，无冠心病、高血压、糖尿病等病史，否认痢疾、伤寒、疟疾、结核病史及密切接触史。无外伤手术史，无输血史。无药物及食物过敏史，预防接种史不详。
#查体#:中年男性, ......, 神经系统检查未见异常。
#辅助检查#:- 彩色B超: - 肝实质回声增粗，考虑肝硬化可能- 胆囊壁增厚 - 副脾 - 双肾结石 - 腹水- 
-DR胸片:- 心肺膈未见异常
-血液检查:- 凝血酶原时间:36.6秒↑ - 肌钙蛋白I: 0.02ng/ml↑ - 丙氨酸氨基转移酶: 71.36U/L↑ - 天门冬氨酸氨基转移酶: 91.65U/L↑ - 白蛋白: 40.78g/L - 总胆红素: 689.03μmol/L↑ - 直接胆红素: 391.85μmol/L↑ - 中性粒细胞比率: 62.5%
根据以上资料，该患者最有可能的诊断及诊断依据是什么？

Response:

<think>
The patient presents with jaundice, abdominal distension, oliguria, fatigue, poor appetite, and bilateral lower limb edema for half a month. He has a history of hepatitis B. The medical history includes antiviral and anti-infectious treatments with albumin supplementation, but symptoms worsened. Examination reveals a middle-aged male patient with some concerning lab results.

Let's break down the information and consider possible diagnoses:

1. **Jaundice (high total and direct bilirubin):** This is a key symptom indicating a liver issue or biliary obstruction. The high direct bilirubin suggests a post-hepatic cause or impaired bilirubin excretion.
2. **Abdominal Distension and Ascites:** Suggests portal hypertension, often secondary to liver disease.
3. **Oliguria:** Could be due to underlying kidney problems or related to liver failure (hepatorenal syndrome).
4. **Fatigue & Poor Appetite:** Common in severe liver disease.
5. **Bilateral Lower Limb Edema:** This, combined with ascites, strongly indicates portal hypertension and albumin loss.
6. **Hepatitis B History:** This is a very important piece of information, suggesting chronic liver disease progression.
7. **Ultrasound Findings:** Liver parenchymal thickening and gallbladder wall thickening support liver disease. Presence of ascites is consistent with portal hypertension. Kidney stones are likely incidental.
8. **Lab Results:**
    * **Prolonged Prothrombin Time (PT - 36.6s):** Indicates impaired liver synthesis of clotting factors, a sign of liver dysfunction.
    * **Elevated ALT and AST:** Suggests hepatocellular injury.
    * **Low Albumin (40.78 g/L):** Indicates impaired liver protein synthesis, contributing to edema and ascites.
    * **Elevated Troponin I (0.02 ng/ml):** While slightly elevated, it's unlikely to be the primary cause, though it warrants monitoring and rule out cardiac issues.
    * **High Neutrophil Ratio (62.5%):** Suggests an inflammatory process or infection.

Considering all these factors, the most likely diagnosis is **decompensated liver cirrhosis secondary to chronic hepatitis B infection.** The patient's history of hepatitis B, the ultrasound findings of liver parenchymal changes, the lab abnormalities (prolonged PT, low albumin, elevated liver enzymes), ascites, edema, and jaundice all strongly support this diagnosis. The worsening of symptoms despite prior treatment suggests the disease has progressed to a decompensated stage.

</think><answer>The most likely diagnosis is decompensated liver cirrhosis secondary to chronic hepatitis B infection. Diagnostic basis includes: 1) History of hepatitis B, 2) Jaundice with elevated total and direct bilirubin, 3) Abdominal distension and ascites, 4) Prolonged prothrombin time (PT), 5) Low albumin, 6) Elevated ALT and AST, 7) Ultrasound findings of liver parenchymal thickening and ascites.</answer>

• Example 6: From MedXpertQA

User:

A 60-year-old-female with hypertension and diabetes is in the emergency department complaining of 3 days of worsening back pain. The pain is located at the site of a surgery 2 weeks ago for a herniated disc. She has also been experiencing one day of fevers, chills, and fatigue. Her vital signs are as follows: temperature 38.4°C (101.1°F), heart rate 96/min, respiratory rate 18/min, blood pressure 152/92 mm Hg. On her physical exam, the patient is alert and oriented, but appears acutely ill and is unable to lie supine due to discomfort. Her lungs are clear to auscultation in all fields, her heart rate is tachycardic with no audible murmurs, rubs, or gallops. Pulling aside her hospital gown, you see an area of erythema over the midline of her spine at the level L3/L4 at the site of her recent surgery that is exquisitely tender to gentle palpation. You place orders for this patient to include blood work of a CBC, blood cultures, CMP, ESR and CRP, imaging for a CT scan and MRI, request IV fluids, broad-spectrum antibiotics and call the spinal surgeon who performed her previous surgery as a consult. As you wait for each of these components of her work up to be undertaken, you consider what osteopathic techniques you have learned that might help your patient in this situation, and what might be appropriate given her possible diagnosis. Which of the following is true regarding the relevant indications or contraindications for such a case?
Answer Choices: (A) Indirect techniques to increase lymphatic drainage would be contraindicated in this patient who presents with an acute fever and whose workup is not complete (B) Due to its gentle and rhythmic application, direct articulation of the involved joint would be indicated as it would provide the most beneficial response (C) The presence of a red reflex visible over her lumbar region is an indication that HVLA should be directed towards that area (D) Articulatory treatment to the lumbar spine would be contraindicated due to the possibility of an acutely inflamed lumbar joint space (E) Any patient experiencing a fever in the post-operative period like this patient indicates that rib raising should be performed due to the high likelihood of atelectasis or pneumonia (F) Counterstrain techniques targeting the lumbar region would be indicated to alleviate the acute inflammatory response (G) Myofascial release techniques are contraindicated in the presence of post-operative fever and erythema over the surgical site (H) Lymphatic pump techniques should be prioritized to address systemic inflammation and fever (I) HVLA is contraindicated in this patient due to the possibility of underlying infection or abscess formation (J) Facilitated positional release targeting the lumbar spine is the optimal choice for managing acute post-operative inflammation

Response:

<think>Okay, let's break down this case and the answer choices. The patient presents with post-operative back pain, fever, chills, and erythema at the surgical site. This strongly suggests a possible infection (e.g., wound infection, abscess, or even a discitis/osteomyelitis). The patient also has hypertension and diabetes, which are important comorbidities to consider.

The question asks about appropriate osteopathic techniques *while waiting* for diagnostic results. We need to be cautious given the possibility of infection.

Let's analyze the answer choices:

(A) Indirect techniques to increase lymphatic drainage would be contraindicated... - This is a reasonable consideration. Increased lymphatic drainage could potentially spread infection.
(B) Direct articulation of the involved joint would be indicated... - Absolutely not. Manipulating an acutely inflamed joint with possible infection is dangerous and could worsen the situation.
(C) The presence of a red reflex... - A "red reflex" isn't a standard term in osteopathic medicine related to HVLA.
(D) Articulatory treatment to the lumbar spine would be contraindicated... - This aligns with the concern about exacerbating a possible infection.  It's prudent to avoid manipulation.
(E) Any patient experiencing a fever... indicates that rib raising should be performed... - This is irrelevant to the lumbar spine and the patient's presentation.
(F) Counterstrain techniques targeting the lumbar region would be indicated... - While counterstrain is generally gentle, the potential for spreading infection makes it unwise in this scenario.
(G) Myofascial release techniques are contraindicated... - Similar to counterstrain, the risk of spread outweighs any potential benefit.
(H) Lymphatic pump techniques should be prioritized... - As mentioned in (A), this is likely contraindicated.
(I) HVLA is contraindicated... - High-velocity, low-amplitude (HVLA) manipulation is definitely contraindicated given the possibility of infection and abscess.
(J) Facilitated positional release targeting the lumbar spine is the optimal choice... - This is also risky given the potential for infection.

Considering the likely diagnosis and the need for caution, the most appropriate answer is (I) and (D). However, most of the choices are incorrect, and (I) is the strongest and most direct answer.

</think><answer> (I) HVLA is contraindicated in this patient due to the possibility of underlying infection or abscess formation. </answer>

Note: This answer is wrong, may lack the knowledge.

• Example 6: From MedXpertQA

User:

A previously healthy 46-year-old woman reports one week of malaise, fever, and skin rash. Her medical history is significant only for a recent case of uncomplicated acute bacterial rhinosinusitis, for which she began taking amoxicillin-clavulanate 6 days ago. Her nasal discharge and facial pain have improved. She reports no cough, abdominal pain, diarrhea, or dysuria.


On physical examination, she has a temperature of 38.3°C, a blood pressure of 148/92 mm Hg, a heart rate of 88 beats per minute, and a respiratory rate of 14 breaths per minute. A diffuse erythematous maculopapular rash is present over her chest and back. The rest of her physical examination is within normal limits.


Her serum creatinine level is 1.8 mg/dL, compared with 0.9 mg/dL one year ago (reference range, 0.6–1.1). Other laboratory results are as follows:

| | Patient value | Reference range |
| --- | --- | --- |
| Hematocrit (%) | 37 | 36–46 |
| Leukocyte count (per mm3) | 9760 | 4500–11,000 |
| Neutrophils (per mm3) | 6800 | 1900–7600 |
| Lymphocytes (per mm3) | 2000 | 800–4100 |
| Eosinophils (per mm3) | 750 | 0–350 |
| Platelets (per mm3) | 480,000 | 150,000–350,000 |
| Sodium (mEq/liter) | 135 | 136–145 |
| Potassium (mEq/liter) | 5.3 | 3.5–5.0 |
| Blood urea nitrogen (mg/dL) | 34 | 10–20 |


Urinalysis reveals 31 to 40 white cells per high-power field (reference range, 0–2) and a urine protein-to-creatinine ratio of 1.1 mg/mg (<0.2).


Which one of the following next steps in evaluation is most appropriate for this patient?
Answer Choices: (A) Perform kidney biopsy (B) Measure antistreptolysin O titer (C) No immediate testing is necessary; discontinue amoxicillin-clavulanate (D) Assess the urine for eosinophils (E) Assess for antineutrophil cytoplasmic antigen antibodies (F) Measure serum complement levels (G) Perform renal ultrasound with Doppler studies (H) Prescribe corticosteroids immediately without further testing (I) Evaluate for systemic lupus erythematosus with ANA testing (J) Check for hepatitis B and C serologies

Response:

<think>The patient presents with a fever, rash, and elevated creatinine, along with eosinophilia and pyuria. The recent use of amoxicillin-clavulanate raises suspicion for a drug-induced hypersensitivity reaction, specifically DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) syndrome. Let's break down the findings and why each answer choice is or isn't appropriate.

*   **Fever, rash, and malaise:** Consistent with a hypersensitivity reaction.
*   **Elevated creatinine (1.8 mg/dL) and pyuria (31-40 WBCs/hpf):** Indicate kidney involvement.
*   **Eosinophilia (750 eosinophils/mm3):** A hallmark of DRESS syndrome.
*   **Recent amoxicillin-clavulanate use:** A common trigger for DRESS.
*   **Elevated BUN (34 mg/dL):** Supports kidney dysfunction.
*   **Urine protein-to-creatinine ratio (1.1 mg/mg):** Suggests proteinuria.

Now let's evaluate the answer choices:

*   **(A) Perform kidney biopsy:** While kidney involvement is present, a biopsy is not the *initial* step. We need to rule out DRESS first.
*   **(B) Measure antistreptolysin O titer:** This is irrelevant to the patient's current presentation.
*   **(C) No immediate testing is necessary; discontinue amoxicillin-clavulanate:** Discontinuation of the suspected drug is crucial, but further investigation is also needed to confirm DRESS and assess the extent of kidney involvement.
*   **(D) Assess the urine for eosinophils:** While eosinophiluria can be seen in DRESS, it’s not a standard or highly sensitive test.
*   **(E) Assess for antineutrophil cytoplasmic antigen antibodies (ANCA):** ANCA is associated with vasculitis, which is less likely given the clinical picture.
*   **(F) Measure serum complement levels:** Complement levels can be helpful in certain autoimmune conditions, but not the primary next step here.
*   **(G) Perform renal ultrasound with Doppler studies:** This would be useful to evaluate for structural abnormalities or obstruction, but it's not the priority.
*   **(H) Prescribe corticosteroids immediately without further testing:** Starting steroids without confirming the diagnosis could be harmful.
*   **(I) Evaluate for systemic lupus erythematosus with ANA testing:** While SLE can cause similar symptoms, DRESS is more likely given the recent antibiotic use and eosinophilia. ANA testing could be considered later if DRESS is ruled out.
*   **(J) Check for hepatitis B and C serologies:** These are not directly related to the patient's presentation.

The most appropriate next step is to discontinue the amoxicillin-clavulanate and assess for DRESS syndrome. Further testing, such as ANA, complement levels, and renal imaging, may be considered later depending on the patient's response to discontinuing the medication.</think><answer>(C) No immediate testing is necessary; discontinue amoxicillin-clavulanate</answer>

Note: This answer is right.

Detail Results

MMLU

Fig.1 The results on the MMLU benchmark.

Fig.2 The results on the MMLU-Humanities

Fig.3 The results on the MMLU-Social Science

Fig.4 The results on the MMLU-STEM

Fig.5 The results on the MMLU-Other

MMLU-Pro

Fig.6 The results on the MMLU-Pro

CMMLU

Fig.7 The results on the CMMLU benchmark.

Fig.8 The results on the CMMLU-Humanities

Fig.9 The results on the CMMLU-Social Science

Fig.10 The results on the CMMLU-STEM

Fig.11 The results on the CMMLU-Other

Fig.12 The results on the CMMLU-China Specific

Acknowledge

Gemma-3-12b-it

Unlsoth

Citation

@software{Qiu_Open-Medical-R1,
author = {Qiu, Zhongxi and Zhang, Zhang and Hu, Yan and Li, Heng and Liu, Jiang},
license = {MIT},
title = {{Open-Medical-R1}},
url = {https://github.com/Qsingle/open-medical-r1},
version = {0.1}
}