Lemur: A Single-Cell Foundation Model for Drosophila melanogaster 🪰🔬

Lemur is a single-cell foundation model developed specifically for Drosophila melanogaster. It achieves fine-tuning-free cell-type annotation using two key innovations:

• Comprehensive Pre-training: Trained on an integrated whole-organism atlas with a unified cell-type annotation schema.
• Hierarchical Decoding: Employs a transformer-based hierarchical cell-type decoder to generate consistent predictions at multiple levels of granularity.

Highlights ⚡️

• Fine-Tuning-Free Annotation: No extra training required on new datasets.
• Robust Across Conditions: Consistent performance across various tissue types, experimental conditions, and sequencing platforms.
• Zero-Shot Batch-Effect Correction: Automatically corrects batch effects without further adjustments.
• Broad Applications: Tailored for the fly research community with potential implications for aging and neurodegenerative disease studies in humans.

Status & Availability 🚀

• Model Weights: Available now on the Hugging Face Hub 🏋🏻‍♂️.
• Code: Soon to be released. Stay tuned! 🔥👀

Publication & Citation 📚🔗

We're excited to share our manuscript, Lemur: A Single-Cell Foundation Model with Fine-Tuning-Free Hierarchical Cell-Type Generation for Drosophila melanogaster, which is now available as a preprint on bioRxiv: 10.1101/123456! 🚀✨

If you find our work helpful, please consider citing our preprint as follows:

@article{your_citation_key,
  title={Lemur: A Single-Cell Foundation Model with Fine-Tuning-Free Hierarchical Cell-Type Generation for *Drosophila melanogaster*},
  author={Doe, John and Smith, Jane and Collaborators},
  journal={bioRxiv},
  year={2025},
  doi={10.1101/123456}
}