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--- |
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license: other |
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license_name: non-commercial-license-dyna1 |
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license_link: https://github.com/WaymentSteeleLab/Dyna-1/blob/main/LICENSE.txt |
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datasets: |
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- gelnesr/RelaxDB |
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base_model: |
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- EvolutionaryScale/esm3-sm-open-v1 |
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- facebook/esm2_t30_150M_UR50D |
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tags: |
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- proteins |
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- nmr |
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- dyna1 |
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--- |
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[](https://colab.research.google.com/github/WaymentSteeleLab/Dyna-1/blob/main/colab/Dyna_1.ipynb) |
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[](https://github.com/WaymentSteeleLab/Dyna-1) |
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# Dyna-1 Model Card |
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Dyna-1 is a model introduced in our paper, ["Learning millisecond protein dynamics from what is missing in NMR spectra"](https://www.biorxiv.org/content/10.1101/2025.03.19.642801v1). |
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Given a sequence and/or structure, Dyna-1 will predict the probability that each residue experiences micro-millisecond motions. |
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Dyna-1 was achieved using the `esm3-sm-open-v1` weights from ESM-3. Inference with this model is subject to the EvolutionaryScale Cambrian Non-Commercial License Agreement of the ESM-3 Model and requires read permission of the weights found [here](https://huggingface.co/EvolutionaryScale/esm3-sm-open-v1). We also make available an alternate version of Dyna-1 that uses ESM-2 embeddings; use of this model is subject to a Non-Commercial License Agreement. |
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If you are using our code, datasets, or model, please use the following citation: |
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```bibtex |
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@article {Dyna-1, |
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author = {Wayment-Steele, Hannah K. and El Nesr, Gina and Hettiarachchi, Ramith and Kariyawasam, Hasindu and Ovchinnikov, Sergey and Kern, Dorothee}, |
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title = {Learning millisecond protein dynamics from what is missing in NMR spectra}, |
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year = {2025}, |
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doi = {10.1101/2025.03.19.642801}, |
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journal = {bioRxiv} |
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} |
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``` |
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