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PMC516018_F8_414.jpg | Describe the main subject of this image. | Distribution of keratin IFs and K8 pS79 in hepatocytes from GF-fed FVB/n mice. A, C keratin IFs; B, D K8 pS79; A, B, C, D 5 month treatment. Asterisks in A and B indicate MBs reactive with Troma 1 but not with LJ4; arrows in C and D indicate MBs reactive with Troma 1 and LJ4, respectively. Scale bar = 20 μm. |
PMC516018_F8_413.jpg | What is the focal point of this photograph? | Distribution of keratin IFs and K8 pS79 in hepatocytes from GF-fed FVB/n mice. A, C keratin IFs; B, D K8 pS79; A, B, C, D 5 month treatment. Asterisks in A and B indicate MBs reactive with Troma 1 but not with LJ4; arrows in C and D indicate MBs reactive with Troma 1 and LJ4, respectively. Scale bar = 20 μm. |
PMC516018_F8_411.jpg | What is the dominant medical problem in this image? | Distribution of keratin IFs and K8 pS79 in hepatocytes from GF-fed FVB/n mice. A, C keratin IFs; B, D K8 pS79; A, B, C, D 5 month treatment. Asterisks in A and B indicate MBs reactive with Troma 1 but not with LJ4; arrows in C and D indicate MBs reactive with Troma 1 and LJ4, respectively. Scale bar = 20 μm. |
PMC516028_F4_424.jpg | What can you see in this picture? | Expression of IGFBP3 and RXRalpha in human prostate tissues. Immunohistochemical staining for IGFBP3 is present as brown staining in normal prostate (A) and prostate cancer (C). Similarly RXRalpha expression is present in normal prostate (B) and lost in prostate cancer (D). All images recorded at 100× magnification. |
PMC516028_F4_426.jpg | What does this image primarily show? | Expression of IGFBP3 and RXRalpha in human prostate tissues. Immunohistochemical staining for IGFBP3 is present as brown staining in normal prostate (A) and prostate cancer (C). Similarly RXRalpha expression is present in normal prostate (B) and lost in prostate cancer (D). All images recorded at 100× magnification. |
PMC516028_F4_423.jpg | What key item or scene is captured in this photo? | Expression of IGFBP3 and RXRalpha in human prostate tissues. Immunohistochemical staining for IGFBP3 is present as brown staining in normal prostate (A) and prostate cancer (C). Similarly RXRalpha expression is present in normal prostate (B) and lost in prostate cancer (D). All images recorded at 100× magnification. |
PMC516028_F4_425.jpg | What is shown in this image? | Expression of IGFBP3 and RXRalpha in human prostate tissues. Immunohistochemical staining for IGFBP3 is present as brown staining in normal prostate (A) and prostate cancer (C). Similarly RXRalpha expression is present in normal prostate (B) and lost in prostate cancer (D). All images recorded at 100× magnification. |
PMC516043_F1_429.jpg | What is shown in this image? | The Secteur and its transmission through contamination tests in Nectria haematococca. (A) Wild-type strain exhibiting three spontaneous Secteurs (1, 2, 3). (B) s*789 mutant. (C) Contamination tests, using plugs from a Secteur or from s*789, on wild type (wt), result in one Secteur at each infection point. (D)Contamination tests on s1 mutant did not result in the induction of any Secteur at the infection points. |
PMC516043_F1_428.jpg | What can you see in this picture? | The Secteur and its transmission through contamination tests in Nectria haematococca. (A) Wild-type strain exhibiting three spontaneous Secteurs (1, 2, 3). (B) s*789 mutant. (C) Contamination tests, using plugs from a Secteur or from s*789, on wild type (wt), result in one Secteur at each infection point. (D)Contamination tests on s1 mutant did not result in the induction of any Secteur at the infection points. |
PMC516786_F5_439.jpg | What is the focal point of this photograph? | Importance of machine settings for using contrast for LV opacification. (a) In this example, endocardial border definition is probably adequate with standard tissue harmonic imaging – [see additional file 2.] (b) The use of contrast for LVO with standard diagnostic harmonic imaging machine settings provides worse border definition in the lateral wall, and apical bubble destruction, illustrating the importance of appropriate machine settings – [see additional file 3]. Image (c) shows machine settings for myocardial perfusion imaging – this provides assessment of myocardial perfusion and wall motion, but the frame rate for WMA is 20–25 Hz and thus subtle WMA's could be missed – [see additional file 4]. Therefore for optimal assessment of WMA image (d) displays specific intermediate MI imaging at high frame rate designed specifically to enhance the endocardial/cavity border. Even in this example there is some apical swirling despite the focal zone set in the mid LV – [see also additional file 5]. |
PMC516786_F5_440.jpg | Can you identify the primary element in this image? | Importance of machine settings for using contrast for LV opacification. (a) In this example, endocardial border definition is probably adequate with standard tissue harmonic imaging – [see additional file 2.] (b) The use of contrast for LVO with standard diagnostic harmonic imaging machine settings provides worse border definition in the lateral wall, and apical bubble destruction, illustrating the importance of appropriate machine settings – [see additional file 3]. Image (c) shows machine settings for myocardial perfusion imaging – this provides assessment of myocardial perfusion and wall motion, but the frame rate for WMA is 20–25 Hz and thus subtle WMA's could be missed – [see additional file 4]. Therefore for optimal assessment of WMA image (d) displays specific intermediate MI imaging at high frame rate designed specifically to enhance the endocardial/cavity border. Even in this example there is some apical swirling despite the focal zone set in the mid LV – [see also additional file 5]. |
PMC516786_F6_432.jpg | What stands out most in this visual? | Realtime 3D echocardiography without (a) – [additional file 6], and with contrast enhancement (b) [additional file 7]. There is clear benefit for LV border detection. [See also additional files 8 and 9 for real time 3-D movies without and with contrast respectively.] |
PMC516786_F6_431.jpg | What is the core subject represented in this visual? | Realtime 3D echocardiography without (a) – [additional file 6], and with contrast enhancement (b) [additional file 7]. There is clear benefit for LV border detection. [See also additional files 8 and 9 for real time 3-D movies without and with contrast respectively.] |
PMC516786_F6_430.jpg | What is the dominant medical problem in this image? | Realtime 3D echocardiography without (a) – [additional file 6], and with contrast enhancement (b) [additional file 7]. There is clear benefit for LV border detection. [See also additional files 8 and 9 for real time 3-D movies without and with contrast respectively.] |
PMC516786_F7_433.jpg | Can you identify the primary element in this image? | End systolic frames of 4CV at rest (left) and post stress (right). Note there is no obvious difference in the shape of the cavity on the grey scale images. Importantly, the LVO images demonstrate a clear change in shape with the basal and mid lateral segments lagging, suggestive of LCx stenosis. In addition, the mid lateral segment has a perfusion defect which was not present at rest. Subtotal occlusion of the LCx was demonstrated at angiography. [See also additional files 10-23 for entire study]. |
PMC516786_F7_434.jpg | What's the most prominent thing you notice in this picture? | End systolic frames of 4CV at rest (left) and post stress (right). Note there is no obvious difference in the shape of the cavity on the grey scale images. Importantly, the LVO images demonstrate a clear change in shape with the basal and mid lateral segments lagging, suggestive of LCx stenosis. In addition, the mid lateral segment has a perfusion defect which was not present at rest. Subtotal occlusion of the LCx was demonstrated at angiography. [See also additional files 10-23 for entire study]. |
PMC516786_F7_435.jpg | What is shown in this image? | End systolic frames of 4CV at rest (left) and post stress (right). Note there is no obvious difference in the shape of the cavity on the grey scale images. Importantly, the LVO images demonstrate a clear change in shape with the basal and mid lateral segments lagging, suggestive of LCx stenosis. In addition, the mid lateral segment has a perfusion defect which was not present at rest. Subtotal occlusion of the LCx was demonstrated at angiography. [See also additional files 10-23 for entire study]. |
PMC516786_F7_437.jpg | What object or scene is depicted here? | End systolic frames of 4CV at rest (left) and post stress (right). Note there is no obvious difference in the shape of the cavity on the grey scale images. Importantly, the LVO images demonstrate a clear change in shape with the basal and mid lateral segments lagging, suggestive of LCx stenosis. In addition, the mid lateral segment has a perfusion defect which was not present at rest. Subtotal occlusion of the LCx was demonstrated at angiography. [See also additional files 10-23 for entire study]. |
PMC516786_F7_436.jpg | What's the most prominent thing you notice in this picture? | End systolic frames of 4CV at rest (left) and post stress (right). Note there is no obvious difference in the shape of the cavity on the grey scale images. Importantly, the LVO images demonstrate a clear change in shape with the basal and mid lateral segments lagging, suggestive of LCx stenosis. In addition, the mid lateral segment has a perfusion defect which was not present at rest. Subtotal occlusion of the LCx was demonstrated at angiography. [See also additional files 10-23 for entire study]. |
PMC516786_F10_450.jpg | What is the main focus of this visual representation? | Contribution of regional shape changes to the identification of perfusion defects, including irregular wall contour in the apex (a) and mid-inferior segment (b), both associated with subendocardial defects. The C shape of the basal inferior segment complements the diagnosis of a perfusion defect in this segment. (c) |
PMC516786_F10_449.jpg | What is the focal point of this photograph? | Contribution of regional shape changes to the identification of perfusion defects, including irregular wall contour in the apex (a) and mid-inferior segment (b), both associated with subendocardial defects. The C shape of the basal inferior segment complements the diagnosis of a perfusion defect in this segment. (c) |
PMC516786_F10_448.jpg | What is the dominant medical problem in this image? | Contribution of regional shape changes to the identification of perfusion defects, including irregular wall contour in the apex (a) and mid-inferior segment (b), both associated with subendocardial defects. The C shape of the basal inferior segment complements the diagnosis of a perfusion defect in this segment. (c) |
PMC516786_F12_454.jpg | What is the principal component of this image? | A clear apical defect is evident 2 beats post flash at peak stress (bottom line) which was not evident at rest (top line), consistent with LAD stenosis. [See additional files 26-39 for full case movies, additional file 40 for angiogram and additional file 49 for curve fits]. |
PMC516786_F12_452.jpg | What is the focal point of this photograph? | A clear apical defect is evident 2 beats post flash at peak stress (bottom line) which was not evident at rest (top line), consistent with LAD stenosis. [See additional files 26-39 for full case movies, additional file 40 for angiogram and additional file 49 for curve fits]. |
PMC516786_F12_455.jpg | What stands out most in this visual? | A clear apical defect is evident 2 beats post flash at peak stress (bottom line) which was not evident at rest (top line), consistent with LAD stenosis. [See additional files 26-39 for full case movies, additional file 40 for angiogram and additional file 49 for curve fits]. |
PMC516786_F12_453.jpg | What does this image primarily show? | A clear apical defect is evident 2 beats post flash at peak stress (bottom line) which was not evident at rest (top line), consistent with LAD stenosis. [See additional files 26-39 for full case movies, additional file 40 for angiogram and additional file 49 for curve fits]. |
PMC516786_F12_451.jpg | What object or scene is depicted here? | A clear apical defect is evident 2 beats post flash at peak stress (bottom line) which was not evident at rest (top line), consistent with LAD stenosis. [See additional files 26-39 for full case movies, additional file 40 for angiogram and additional file 49 for curve fits]. |
PMC516786_F12_456.jpg | Describe the main subject of this image. | A clear apical defect is evident 2 beats post flash at peak stress (bottom line) which was not evident at rest (top line), consistent with LAD stenosis. [See additional files 26-39 for full case movies, additional file 40 for angiogram and additional file 49 for curve fits]. |
PMC516786_F13_446.jpg | What is the central feature of this picture? | A basal and mid inferior defect is evident 2 beats post flash at peak stress which was not evident at rest, consistent with RCA stenosis. [See additional files 41-46 for movies and 47 and 48 for angiography]. |
PMC516786_F13_447.jpg | What is being portrayed in this visual content? | A basal and mid inferior defect is evident 2 beats post flash at peak stress which was not evident at rest, consistent with RCA stenosis. [See additional files 41-46 for movies and 47 and 48 for angiography]. |
PMC516786_F13_443.jpg | What is the focal point of this photograph? | A basal and mid inferior defect is evident 2 beats post flash at peak stress which was not evident at rest, consistent with RCA stenosis. [See additional files 41-46 for movies and 47 and 48 for angiography]. |
PMC516786_F17_461.jpg | What is shown in this image? | Resting apical 2-chamber view, 10 beats post-flash, demonstrating absent perfusion to the anterior myocardial wall. |
PMC516788_F1_457.jpg | What is the core subject represented in this visual? | Mammography of the patients' breasts (A: mediolateral oblique, view B: craniocaudal view) |
PMC516788_F1_460.jpg | What key item or scene is captured in this photo? | Mammography of the patients' breasts (A: mediolateral oblique, view B: craniocaudal view) |
PMC516790_F1_468.jpg | What is shown in this image? | Representative micrographs from the ovary of immature rats primed with eCG at 21 (A-D, G, H) or 23 (E, F) days of age, stained with hematoxylin and eosin. A, luteinized follicle showing trapped COC and release of follicular fluid (FF) to the ovarian interstitium. The rupture of the theca layers are indicated by arrows. B, COC released to the ovarian interstitium, in a lacunae of follicular fluid (FF). Clusters of granulosa cells are indicated by open arrows. C, D, COCs in the lymphatic (A) or blood (D) vessels at the ovarian hilus (OH). E, F, COC inside a blood vessel located in the periovarian fat pad (PFP) near the ovarian hilus (OH). The framed area is shown at higher magnification in F showing rupture of the blood vessel and escape of red blood cells (arrows). G, H, Non-consecutive serial sections showing a COC released to the bursal cavity (BC), adhered to the ovarian bursa. Degradation of the ovarian bursa by follicular fluid and granulosa cells (open arrows) and invasion (arrows) of the periovarian fat pad (PFP) can be observed. |
PMC516790_F1_465.jpg | What object or scene is depicted here? | Representative micrographs from the ovary of immature rats primed with eCG at 21 (A-D, G, H) or 23 (E, F) days of age, stained with hematoxylin and eosin. A, luteinized follicle showing trapped COC and release of follicular fluid (FF) to the ovarian interstitium. The rupture of the theca layers are indicated by arrows. B, COC released to the ovarian interstitium, in a lacunae of follicular fluid (FF). Clusters of granulosa cells are indicated by open arrows. C, D, COCs in the lymphatic (A) or blood (D) vessels at the ovarian hilus (OH). E, F, COC inside a blood vessel located in the periovarian fat pad (PFP) near the ovarian hilus (OH). The framed area is shown at higher magnification in F showing rupture of the blood vessel and escape of red blood cells (arrows). G, H, Non-consecutive serial sections showing a COC released to the bursal cavity (BC), adhered to the ovarian bursa. Degradation of the ovarian bursa by follicular fluid and granulosa cells (open arrows) and invasion (arrows) of the periovarian fat pad (PFP) can be observed. |
PMC516790_F1_467.jpg | What is the main focus of this visual representation? | Representative micrographs from the ovary of immature rats primed with eCG at 21 (A-D, G, H) or 23 (E, F) days of age, stained with hematoxylin and eosin. A, luteinized follicle showing trapped COC and release of follicular fluid (FF) to the ovarian interstitium. The rupture of the theca layers are indicated by arrows. B, COC released to the ovarian interstitium, in a lacunae of follicular fluid (FF). Clusters of granulosa cells are indicated by open arrows. C, D, COCs in the lymphatic (A) or blood (D) vessels at the ovarian hilus (OH). E, F, COC inside a blood vessel located in the periovarian fat pad (PFP) near the ovarian hilus (OH). The framed area is shown at higher magnification in F showing rupture of the blood vessel and escape of red blood cells (arrows). G, H, Non-consecutive serial sections showing a COC released to the bursal cavity (BC), adhered to the ovarian bursa. Degradation of the ovarian bursa by follicular fluid and granulosa cells (open arrows) and invasion (arrows) of the periovarian fat pad (PFP) can be observed. |
PMC516790_F1_463.jpg | What does this image primarily show? | Representative micrographs from the ovary of immature rats primed with eCG at 21 (A-D, G, H) or 23 (E, F) days of age, stained with hematoxylin and eosin. A, luteinized follicle showing trapped COC and release of follicular fluid (FF) to the ovarian interstitium. The rupture of the theca layers are indicated by arrows. B, COC released to the ovarian interstitium, in a lacunae of follicular fluid (FF). Clusters of granulosa cells are indicated by open arrows. C, D, COCs in the lymphatic (A) or blood (D) vessels at the ovarian hilus (OH). E, F, COC inside a blood vessel located in the periovarian fat pad (PFP) near the ovarian hilus (OH). The framed area is shown at higher magnification in F showing rupture of the blood vessel and escape of red blood cells (arrows). G, H, Non-consecutive serial sections showing a COC released to the bursal cavity (BC), adhered to the ovarian bursa. Degradation of the ovarian bursa by follicular fluid and granulosa cells (open arrows) and invasion (arrows) of the periovarian fat pad (PFP) can be observed. |
PMC516790_F1_466.jpg | What is the principal component of this image? | Representative micrographs from the ovary of immature rats primed with eCG at 21 (A-D, G, H) or 23 (E, F) days of age, stained with hematoxylin and eosin. A, luteinized follicle showing trapped COC and release of follicular fluid (FF) to the ovarian interstitium. The rupture of the theca layers are indicated by arrows. B, COC released to the ovarian interstitium, in a lacunae of follicular fluid (FF). Clusters of granulosa cells are indicated by open arrows. C, D, COCs in the lymphatic (A) or blood (D) vessels at the ovarian hilus (OH). E, F, COC inside a blood vessel located in the periovarian fat pad (PFP) near the ovarian hilus (OH). The framed area is shown at higher magnification in F showing rupture of the blood vessel and escape of red blood cells (arrows). G, H, Non-consecutive serial sections showing a COC released to the bursal cavity (BC), adhered to the ovarian bursa. Degradation of the ovarian bursa by follicular fluid and granulosa cells (open arrows) and invasion (arrows) of the periovarian fat pad (PFP) can be observed. |
PMC516790_F1_464.jpg | What key item or scene is captured in this photo? | Representative micrographs from the ovary of immature rats primed with eCG at 21 (A-D, G, H) or 23 (E, F) days of age, stained with hematoxylin and eosin. A, luteinized follicle showing trapped COC and release of follicular fluid (FF) to the ovarian interstitium. The rupture of the theca layers are indicated by arrows. B, COC released to the ovarian interstitium, in a lacunae of follicular fluid (FF). Clusters of granulosa cells are indicated by open arrows. C, D, COCs in the lymphatic (A) or blood (D) vessels at the ovarian hilus (OH). E, F, COC inside a blood vessel located in the periovarian fat pad (PFP) near the ovarian hilus (OH). The framed area is shown at higher magnification in F showing rupture of the blood vessel and escape of red blood cells (arrows). G, H, Non-consecutive serial sections showing a COC released to the bursal cavity (BC), adhered to the ovarian bursa. Degradation of the ovarian bursa by follicular fluid and granulosa cells (open arrows) and invasion (arrows) of the periovarian fat pad (PFP) can be observed. |
PMC516790_F1_469.jpg | What is the principal component of this image? | Representative micrographs from the ovary of immature rats primed with eCG at 21 (A-D, G, H) or 23 (E, F) days of age, stained with hematoxylin and eosin. A, luteinized follicle showing trapped COC and release of follicular fluid (FF) to the ovarian interstitium. The rupture of the theca layers are indicated by arrows. B, COC released to the ovarian interstitium, in a lacunae of follicular fluid (FF). Clusters of granulosa cells are indicated by open arrows. C, D, COCs in the lymphatic (A) or blood (D) vessels at the ovarian hilus (OH). E, F, COC inside a blood vessel located in the periovarian fat pad (PFP) near the ovarian hilus (OH). The framed area is shown at higher magnification in F showing rupture of the blood vessel and escape of red blood cells (arrows). G, H, Non-consecutive serial sections showing a COC released to the bursal cavity (BC), adhered to the ovarian bursa. Degradation of the ovarian bursa by follicular fluid and granulosa cells (open arrows) and invasion (arrows) of the periovarian fat pad (PFP) can be observed. |
PMC516790_F1_462.jpg | What is the dominant medical problem in this image? | Representative micrographs from the ovary of immature rats primed with eCG at 21 (A-D, G, H) or 23 (E, F) days of age, stained with hematoxylin and eosin. A, luteinized follicle showing trapped COC and release of follicular fluid (FF) to the ovarian interstitium. The rupture of the theca layers are indicated by arrows. B, COC released to the ovarian interstitium, in a lacunae of follicular fluid (FF). Clusters of granulosa cells are indicated by open arrows. C, D, COCs in the lymphatic (A) or blood (D) vessels at the ovarian hilus (OH). E, F, COC inside a blood vessel located in the periovarian fat pad (PFP) near the ovarian hilus (OH). The framed area is shown at higher magnification in F showing rupture of the blood vessel and escape of red blood cells (arrows). G, H, Non-consecutive serial sections showing a COC released to the bursal cavity (BC), adhered to the ovarian bursa. Degradation of the ovarian bursa by follicular fluid and granulosa cells (open arrows) and invasion (arrows) of the periovarian fat pad (PFP) can be observed. |
PMC517501_F3_473.jpg | What stands out most in this visual? | Mitochondrial ultrastructure shows heterogeneity between cell lines (same final magnification for the 4 images, marker = 0.5 μm): (A) NB cell line N206: dilated crista spaces in small mitochondria with a dense matrix; (B) NB cell line NMB: small mitochondria with narrow cristae and light matrix, so-called orthodox configuration, (C) NB cell line SJNB-8: unusually large mitochondria in orthodox configuration (narrow cristae), some areas in the matrix are cleared and lack cristae; (D) NB cell line LA-N-2: very large mitochondria with dilated cristae and dense matrix. |
PMC517501_F3_471.jpg | What can you see in this picture? | Mitochondrial ultrastructure shows heterogeneity between cell lines (same final magnification for the 4 images, marker = 0.5 μm): (A) NB cell line N206: dilated crista spaces in small mitochondria with a dense matrix; (B) NB cell line NMB: small mitochondria with narrow cristae and light matrix, so-called orthodox configuration, (C) NB cell line SJNB-8: unusually large mitochondria in orthodox configuration (narrow cristae), some areas in the matrix are cleared and lack cristae; (D) NB cell line LA-N-2: very large mitochondria with dilated cristae and dense matrix. |
PMC517501_F3_472.jpg | What is the principal component of this image? | Mitochondrial ultrastructure shows heterogeneity between cell lines (same final magnification for the 4 images, marker = 0.5 μm): (A) NB cell line N206: dilated crista spaces in small mitochondria with a dense matrix; (B) NB cell line NMB: small mitochondria with narrow cristae and light matrix, so-called orthodox configuration, (C) NB cell line SJNB-8: unusually large mitochondria in orthodox configuration (narrow cristae), some areas in the matrix are cleared and lack cristae; (D) NB cell line LA-N-2: very large mitochondria with dilated cristae and dense matrix. |
PMC517503_F1_478.jpg | What can you see in this picture? | A: Serum Bilirubin levels (μmol/L) for patient 1 (solid line) and for patient 2 (dashed line). The arrowheads indicate the time points where calcifications were detected. B: International Normalization Ratio (INR) for patient 1 (solid line) and for patient 2 (dashed line). Arrowheads indicate the time points where calcifications were detected. C: Computed Tomography of patient 2. The arrow points an area in the right liver with the same density as the spinal column (arrowhead). D: Picture of the explant liver during retransplantation of the same patient (case 2). The arrow shows the abnormal area of the right liver correlating with the computed tomography findings. E: Light microscopy of epoxy embedded semi-section obtained from the liver biopsy from patient 1. The image shows moderate calcification (microcalcification) throughout the section. The arrow indicates a representative pattern of calcification. F: Light microscopy of epoxy embedded semi-section obtained from the tissues of the explant, following liver retransplantation of patient 2. The image shows the interface between calcified region (upper right) and non-calcified adjacent hepatic cells (lower left region). G: Light microscopy image showing a higher magnification of calcified region as shown in F. The bright and high contrast regions represent massive mineralization of hepatic cells of the explant, following retransplantation. H: Transmission electron microscopy images of ultrathin section obtained from the transitional zone between calcified and non-calcified tissue. Showing the mode of calcification and textural organization of hydroxyapatite crystal aggregates (dark contrast) within cytoplasmic region of the cell. Note alteration of the nucleus in the center. |
PMC517503_F1_474.jpg | What's the most prominent thing you notice in this picture? | A: Serum Bilirubin levels (μmol/L) for patient 1 (solid line) and for patient 2 (dashed line). The arrowheads indicate the time points where calcifications were detected. B: International Normalization Ratio (INR) for patient 1 (solid line) and for patient 2 (dashed line). Arrowheads indicate the time points where calcifications were detected. C: Computed Tomography of patient 2. The arrow points an area in the right liver with the same density as the spinal column (arrowhead). D: Picture of the explant liver during retransplantation of the same patient (case 2). The arrow shows the abnormal area of the right liver correlating with the computed tomography findings. E: Light microscopy of epoxy embedded semi-section obtained from the liver biopsy from patient 1. The image shows moderate calcification (microcalcification) throughout the section. The arrow indicates a representative pattern of calcification. F: Light microscopy of epoxy embedded semi-section obtained from the tissues of the explant, following liver retransplantation of patient 2. The image shows the interface between calcified region (upper right) and non-calcified adjacent hepatic cells (lower left region). G: Light microscopy image showing a higher magnification of calcified region as shown in F. The bright and high contrast regions represent massive mineralization of hepatic cells of the explant, following retransplantation. H: Transmission electron microscopy images of ultrathin section obtained from the transitional zone between calcified and non-calcified tissue. Showing the mode of calcification and textural organization of hydroxyapatite crystal aggregates (dark contrast) within cytoplasmic region of the cell. Note alteration of the nucleus in the center. |
PMC517503_F1_476.jpg | What is the central feature of this picture? | A: Serum Bilirubin levels (μmol/L) for patient 1 (solid line) and for patient 2 (dashed line). The arrowheads indicate the time points where calcifications were detected. B: International Normalization Ratio (INR) for patient 1 (solid line) and for patient 2 (dashed line). Arrowheads indicate the time points where calcifications were detected. C: Computed Tomography of patient 2. The arrow points an area in the right liver with the same density as the spinal column (arrowhead). D: Picture of the explant liver during retransplantation of the same patient (case 2). The arrow shows the abnormal area of the right liver correlating with the computed tomography findings. E: Light microscopy of epoxy embedded semi-section obtained from the liver biopsy from patient 1. The image shows moderate calcification (microcalcification) throughout the section. The arrow indicates a representative pattern of calcification. F: Light microscopy of epoxy embedded semi-section obtained from the tissues of the explant, following liver retransplantation of patient 2. The image shows the interface between calcified region (upper right) and non-calcified adjacent hepatic cells (lower left region). G: Light microscopy image showing a higher magnification of calcified region as shown in F. The bright and high contrast regions represent massive mineralization of hepatic cells of the explant, following retransplantation. H: Transmission electron microscopy images of ultrathin section obtained from the transitional zone between calcified and non-calcified tissue. Showing the mode of calcification and textural organization of hydroxyapatite crystal aggregates (dark contrast) within cytoplasmic region of the cell. Note alteration of the nucleus in the center. |
PMC517503_F1_477.jpg | Can you identify the primary element in this image? | A: Serum Bilirubin levels (μmol/L) for patient 1 (solid line) and for patient 2 (dashed line). The arrowheads indicate the time points where calcifications were detected. B: International Normalization Ratio (INR) for patient 1 (solid line) and for patient 2 (dashed line). Arrowheads indicate the time points where calcifications were detected. C: Computed Tomography of patient 2. The arrow points an area in the right liver with the same density as the spinal column (arrowhead). D: Picture of the explant liver during retransplantation of the same patient (case 2). The arrow shows the abnormal area of the right liver correlating with the computed tomography findings. E: Light microscopy of epoxy embedded semi-section obtained from the liver biopsy from patient 1. The image shows moderate calcification (microcalcification) throughout the section. The arrow indicates a representative pattern of calcification. F: Light microscopy of epoxy embedded semi-section obtained from the tissues of the explant, following liver retransplantation of patient 2. The image shows the interface between calcified region (upper right) and non-calcified adjacent hepatic cells (lower left region). G: Light microscopy image showing a higher magnification of calcified region as shown in F. The bright and high contrast regions represent massive mineralization of hepatic cells of the explant, following retransplantation. H: Transmission electron microscopy images of ultrathin section obtained from the transitional zone between calcified and non-calcified tissue. Showing the mode of calcification and textural organization of hydroxyapatite crystal aggregates (dark contrast) within cytoplasmic region of the cell. Note alteration of the nucleus in the center. |
PMC517503_F1_479.jpg | What does this image primarily show? | A: Serum Bilirubin levels (μmol/L) for patient 1 (solid line) and for patient 2 (dashed line). The arrowheads indicate the time points where calcifications were detected. B: International Normalization Ratio (INR) for patient 1 (solid line) and for patient 2 (dashed line). Arrowheads indicate the time points where calcifications were detected. C: Computed Tomography of patient 2. The arrow points an area in the right liver with the same density as the spinal column (arrowhead). D: Picture of the explant liver during retransplantation of the same patient (case 2). The arrow shows the abnormal area of the right liver correlating with the computed tomography findings. E: Light microscopy of epoxy embedded semi-section obtained from the liver biopsy from patient 1. The image shows moderate calcification (microcalcification) throughout the section. The arrow indicates a representative pattern of calcification. F: Light microscopy of epoxy embedded semi-section obtained from the tissues of the explant, following liver retransplantation of patient 2. The image shows the interface between calcified region (upper right) and non-calcified adjacent hepatic cells (lower left region). G: Light microscopy image showing a higher magnification of calcified region as shown in F. The bright and high contrast regions represent massive mineralization of hepatic cells of the explant, following retransplantation. H: Transmission electron microscopy images of ultrathin section obtained from the transitional zone between calcified and non-calcified tissue. Showing the mode of calcification and textural organization of hydroxyapatite crystal aggregates (dark contrast) within cytoplasmic region of the cell. Note alteration of the nucleus in the center. |
PMC517705_F4_482.jpg | What can you see in this picture? | Magnification is ×400. On the left, the surface of the normal non-exposed palate is shown with a continuous ciliary layer, punctuated with secretory gland openings. The middle and right micrographs show the surface of palates exposed to the smoke of four cigarettes. |
PMC517705_F4_483.jpg | What is the focal point of this photograph? | Magnification is ×400. On the left, the surface of the normal non-exposed palate is shown with a continuous ciliary layer, punctuated with secretory gland openings. The middle and right micrographs show the surface of palates exposed to the smoke of four cigarettes. |
PMC517705_F4_484.jpg | What is being portrayed in this visual content? | Magnification is ×400. On the left, the surface of the normal non-exposed palate is shown with a continuous ciliary layer, punctuated with secretory gland openings. The middle and right micrographs show the surface of palates exposed to the smoke of four cigarettes. |
PMC517711_F2_486.jpg | What is the central feature of this picture? | Activation in the contralateral somatosensory cortex during tactile stimulation of the fingers of the right hand versus rest in a single subject. The first column shows transverse anatomical image with z-coordinate indicated. Subsequent columns show the activation patterns in S1 overlayed on magnified T1-weighted images for each finger. The location of the peak voxel in area 3b is indicated by blue crosshairs. |
PMC517711_F2_490.jpg | Can you identify the primary element in this image? | Activation in the contralateral somatosensory cortex during tactile stimulation of the fingers of the right hand versus rest in a single subject. The first column shows transverse anatomical image with z-coordinate indicated. Subsequent columns show the activation patterns in S1 overlayed on magnified T1-weighted images for each finger. The location of the peak voxel in area 3b is indicated by blue crosshairs. |
PMC517711_F2_488.jpg | Describe the main subject of this image. | Activation in the contralateral somatosensory cortex during tactile stimulation of the fingers of the right hand versus rest in a single subject. The first column shows transverse anatomical image with z-coordinate indicated. Subsequent columns show the activation patterns in S1 overlayed on magnified T1-weighted images for each finger. The location of the peak voxel in area 3b is indicated by blue crosshairs. |
PMC517715_F4_492.jpg | What is the core subject represented in this visual? | A 58 year old man, who 8 years ago underwent left hepatectomy and cholecistectomy, for complicated intrahepatic biliary stones, presented with jaundice and weight loss. Enhanced CT scan showed marked intrahepatic biliary dilation. |
PMC517722_F1_503.jpg | Can you identify the primary element in this image? | Comparison of direct immunofluorescence in cryosections of matched skin biopsies transported in liquid nitrogen, Michel's fixative or saline. Note the substantially reduced background fluorescence in saline-transported biopsies. Pemphigus foliaceus showing characteristic IgG fluorescence at the epidermal intercellular space. Additional granular IgG staining at the basement membrane zone (arrow) stands out most clearly in saline transported biopsy. (obj. ×20) Mucous membrane pemphigoid with skin involvement showing weak linear IgG fluorescence at the basement membrane zone that is only visible in the saline transported biopsy (arrow). (obj. ×20) Lupus erythematosus showing granular IgG fluorescence at the dermo-epidermal junction. Additional IgG staining of subepidermal vessel walls is best visible in the saline-transported biopsy. (obj. ×20) Vasculitis showing fine-granular IgA fluorescence in subepidermal capillary walls (arrows) which is most distinct in the saline-transported biopsy. (obj. ×40) |
PMC517722_F1_501.jpg | Describe the main subject of this image. | Comparison of direct immunofluorescence in cryosections of matched skin biopsies transported in liquid nitrogen, Michel's fixative or saline. Note the substantially reduced background fluorescence in saline-transported biopsies. Pemphigus foliaceus showing characteristic IgG fluorescence at the epidermal intercellular space. Additional granular IgG staining at the basement membrane zone (arrow) stands out most clearly in saline transported biopsy. (obj. ×20) Mucous membrane pemphigoid with skin involvement showing weak linear IgG fluorescence at the basement membrane zone that is only visible in the saline transported biopsy (arrow). (obj. ×20) Lupus erythematosus showing granular IgG fluorescence at the dermo-epidermal junction. Additional IgG staining of subepidermal vessel walls is best visible in the saline-transported biopsy. (obj. ×20) Vasculitis showing fine-granular IgA fluorescence in subepidermal capillary walls (arrows) which is most distinct in the saline-transported biopsy. (obj. ×40) |
PMC517722_F1_498.jpg | What's the most prominent thing you notice in this picture? | Comparison of direct immunofluorescence in cryosections of matched skin biopsies transported in liquid nitrogen, Michel's fixative or saline. Note the substantially reduced background fluorescence in saline-transported biopsies. Pemphigus foliaceus showing characteristic IgG fluorescence at the epidermal intercellular space. Additional granular IgG staining at the basement membrane zone (arrow) stands out most clearly in saline transported biopsy. (obj. ×20) Mucous membrane pemphigoid with skin involvement showing weak linear IgG fluorescence at the basement membrane zone that is only visible in the saline transported biopsy (arrow). (obj. ×20) Lupus erythematosus showing granular IgG fluorescence at the dermo-epidermal junction. Additional IgG staining of subepidermal vessel walls is best visible in the saline-transported biopsy. (obj. ×20) Vasculitis showing fine-granular IgA fluorescence in subepidermal capillary walls (arrows) which is most distinct in the saline-transported biopsy. (obj. ×40) |
PMC517722_F1_502.jpg | What is the core subject represented in this visual? | Comparison of direct immunofluorescence in cryosections of matched skin biopsies transported in liquid nitrogen, Michel's fixative or saline. Note the substantially reduced background fluorescence in saline-transported biopsies. Pemphigus foliaceus showing characteristic IgG fluorescence at the epidermal intercellular space. Additional granular IgG staining at the basement membrane zone (arrow) stands out most clearly in saline transported biopsy. (obj. ×20) Mucous membrane pemphigoid with skin involvement showing weak linear IgG fluorescence at the basement membrane zone that is only visible in the saline transported biopsy (arrow). (obj. ×20) Lupus erythematosus showing granular IgG fluorescence at the dermo-epidermal junction. Additional IgG staining of subepidermal vessel walls is best visible in the saline-transported biopsy. (obj. ×20) Vasculitis showing fine-granular IgA fluorescence in subepidermal capillary walls (arrows) which is most distinct in the saline-transported biopsy. (obj. ×40) |
PMC517722_F1_504.jpg | What is the dominant medical problem in this image? | Comparison of direct immunofluorescence in cryosections of matched skin biopsies transported in liquid nitrogen, Michel's fixative or saline. Note the substantially reduced background fluorescence in saline-transported biopsies. Pemphigus foliaceus showing characteristic IgG fluorescence at the epidermal intercellular space. Additional granular IgG staining at the basement membrane zone (arrow) stands out most clearly in saline transported biopsy. (obj. ×20) Mucous membrane pemphigoid with skin involvement showing weak linear IgG fluorescence at the basement membrane zone that is only visible in the saline transported biopsy (arrow). (obj. ×20) Lupus erythematosus showing granular IgG fluorescence at the dermo-epidermal junction. Additional IgG staining of subepidermal vessel walls is best visible in the saline-transported biopsy. (obj. ×20) Vasculitis showing fine-granular IgA fluorescence in subepidermal capillary walls (arrows) which is most distinct in the saline-transported biopsy. (obj. ×40) |
PMC517722_F1_496.jpg | What is the principal component of this image? | Comparison of direct immunofluorescence in cryosections of matched skin biopsies transported in liquid nitrogen, Michel's fixative or saline. Note the substantially reduced background fluorescence in saline-transported biopsies. Pemphigus foliaceus showing characteristic IgG fluorescence at the epidermal intercellular space. Additional granular IgG staining at the basement membrane zone (arrow) stands out most clearly in saline transported biopsy. (obj. ×20) Mucous membrane pemphigoid with skin involvement showing weak linear IgG fluorescence at the basement membrane zone that is only visible in the saline transported biopsy (arrow). (obj. ×20) Lupus erythematosus showing granular IgG fluorescence at the dermo-epidermal junction. Additional IgG staining of subepidermal vessel walls is best visible in the saline-transported biopsy. (obj. ×20) Vasculitis showing fine-granular IgA fluorescence in subepidermal capillary walls (arrows) which is most distinct in the saline-transported biopsy. (obj. ×40) |
PMC517722_F1_495.jpg | What key item or scene is captured in this photo? | Comparison of direct immunofluorescence in cryosections of matched skin biopsies transported in liquid nitrogen, Michel's fixative or saline. Note the substantially reduced background fluorescence in saline-transported biopsies. Pemphigus foliaceus showing characteristic IgG fluorescence at the epidermal intercellular space. Additional granular IgG staining at the basement membrane zone (arrow) stands out most clearly in saline transported biopsy. (obj. ×20) Mucous membrane pemphigoid with skin involvement showing weak linear IgG fluorescence at the basement membrane zone that is only visible in the saline transported biopsy (arrow). (obj. ×20) Lupus erythematosus showing granular IgG fluorescence at the dermo-epidermal junction. Additional IgG staining of subepidermal vessel walls is best visible in the saline-transported biopsy. (obj. ×20) Vasculitis showing fine-granular IgA fluorescence in subepidermal capillary walls (arrows) which is most distinct in the saline-transported biopsy. (obj. ×40) |
PMC517722_F1_497.jpg | What key item or scene is captured in this photo? | Comparison of direct immunofluorescence in cryosections of matched skin biopsies transported in liquid nitrogen, Michel's fixative or saline. Note the substantially reduced background fluorescence in saline-transported biopsies. Pemphigus foliaceus showing characteristic IgG fluorescence at the epidermal intercellular space. Additional granular IgG staining at the basement membrane zone (arrow) stands out most clearly in saline transported biopsy. (obj. ×20) Mucous membrane pemphigoid with skin involvement showing weak linear IgG fluorescence at the basement membrane zone that is only visible in the saline transported biopsy (arrow). (obj. ×20) Lupus erythematosus showing granular IgG fluorescence at the dermo-epidermal junction. Additional IgG staining of subepidermal vessel walls is best visible in the saline-transported biopsy. (obj. ×20) Vasculitis showing fine-granular IgA fluorescence in subepidermal capillary walls (arrows) which is most distinct in the saline-transported biopsy. (obj. ×40) |
PMC517722_F1_505.jpg | Can you identify the primary element in this image? | Comparison of direct immunofluorescence in cryosections of matched skin biopsies transported in liquid nitrogen, Michel's fixative or saline. Note the substantially reduced background fluorescence in saline-transported biopsies. Pemphigus foliaceus showing characteristic IgG fluorescence at the epidermal intercellular space. Additional granular IgG staining at the basement membrane zone (arrow) stands out most clearly in saline transported biopsy. (obj. ×20) Mucous membrane pemphigoid with skin involvement showing weak linear IgG fluorescence at the basement membrane zone that is only visible in the saline transported biopsy (arrow). (obj. ×20) Lupus erythematosus showing granular IgG fluorescence at the dermo-epidermal junction. Additional IgG staining of subepidermal vessel walls is best visible in the saline-transported biopsy. (obj. ×20) Vasculitis showing fine-granular IgA fluorescence in subepidermal capillary walls (arrows) which is most distinct in the saline-transported biopsy. (obj. ×40) |
PMC517722_F1_499.jpg | What is the focal point of this photograph? | Comparison of direct immunofluorescence in cryosections of matched skin biopsies transported in liquid nitrogen, Michel's fixative or saline. Note the substantially reduced background fluorescence in saline-transported biopsies. Pemphigus foliaceus showing characteristic IgG fluorescence at the epidermal intercellular space. Additional granular IgG staining at the basement membrane zone (arrow) stands out most clearly in saline transported biopsy. (obj. ×20) Mucous membrane pemphigoid with skin involvement showing weak linear IgG fluorescence at the basement membrane zone that is only visible in the saline transported biopsy (arrow). (obj. ×20) Lupus erythematosus showing granular IgG fluorescence at the dermo-epidermal junction. Additional IgG staining of subepidermal vessel walls is best visible in the saline-transported biopsy. (obj. ×20) Vasculitis showing fine-granular IgA fluorescence in subepidermal capillary walls (arrows) which is most distinct in the saline-transported biopsy. (obj. ×40) |
PMC517722_F2_493.jpg | What is being portrayed in this visual content? | Direct immunofluorescence (IgG, combined with transmitted light) in saline transported skin specimen of lupus erythematosus. After 48 hours in saline there is subepidermal split formation, not present in fresh-frozen (N2) and fixed (Mi48) skin. Note the still obvious granular IgG fluorescence at the dermal side of the split. (obj. ×40) |
PMC517808_F3_508.jpg | What can you see in this picture? | Scanning electron micrographs of control and MB-treated palates at a magnification of 400× (panels A and B respectively) and at 3500× (panels C and D respectively). In panel A, the ciliated epithelium completely covers the surface of the palate except where the openings to secretory cells are seen. In panel B, it can be seen that the ciliated surface is not continuous, but punctuated with numerous spaces where ciliated cells are not present. Panel C shows the high density of cilia on the palate surface, which under normal transport conditions, beat in a metachronal pattern to move a mucus layer over them. In panel D, the continuity of the ciliated layer is interrupted by spaces where ciliated epithelial cells are no longer present. |
PMC517808_F3_506.jpg | What can you see in this picture? | Scanning electron micrographs of control and MB-treated palates at a magnification of 400× (panels A and B respectively) and at 3500× (panels C and D respectively). In panel A, the ciliated epithelium completely covers the surface of the palate except where the openings to secretory cells are seen. In panel B, it can be seen that the ciliated surface is not continuous, but punctuated with numerous spaces where ciliated cells are not present. Panel C shows the high density of cilia on the palate surface, which under normal transport conditions, beat in a metachronal pattern to move a mucus layer over them. In panel D, the continuity of the ciliated layer is interrupted by spaces where ciliated epithelial cells are no longer present. |
PMC517820_pbio-0020280-g007_513.jpg | What is being portrayed in this visual content? | Growth on Lophenol Induces the Accumulation of DAF-16 in the Nuclei of Neurons in a DAF-12–Dependent Manner(A) When grown on cholesterol, the transgenic line DAF-16a::GFP/bKO displays a diffuse staining in the cytoplasm and nuclei of many cells (only the pharynx region of an L3 larva is shown).(B) Staining of a larva of similar age by Hoechst. Note many nuclei in the pharynx.(C) The DAF-16a::GFP/bKO line grown on lophenol shows strong staining of nuclei in neurons of the pharynx, tail, and ventral cord of a dauer larva.(D) An L3 larva of DAF-16a::GFP/bKO in a daf-12 null background grown on lophenol. Note the diffuse fluorescence in the pharynx cell similar to that shown in (A). |
PMC517820_pbio-0020280-g007_510.jpg | What key item or scene is captured in this photo? | Growth on Lophenol Induces the Accumulation of DAF-16 in the Nuclei of Neurons in a DAF-12–Dependent Manner(A) When grown on cholesterol, the transgenic line DAF-16a::GFP/bKO displays a diffuse staining in the cytoplasm and nuclei of many cells (only the pharynx region of an L3 larva is shown).(B) Staining of a larva of similar age by Hoechst. Note many nuclei in the pharynx.(C) The DAF-16a::GFP/bKO line grown on lophenol shows strong staining of nuclei in neurons of the pharynx, tail, and ventral cord of a dauer larva.(D) An L3 larva of DAF-16a::GFP/bKO in a daf-12 null background grown on lophenol. Note the diffuse fluorescence in the pharynx cell similar to that shown in (A). |
PMC517820_pbio-0020280-g007_514.jpg | What is the focal point of this photograph? | Growth on Lophenol Induces the Accumulation of DAF-16 in the Nuclei of Neurons in a DAF-12–Dependent Manner(A) When grown on cholesterol, the transgenic line DAF-16a::GFP/bKO displays a diffuse staining in the cytoplasm and nuclei of many cells (only the pharynx region of an L3 larva is shown).(B) Staining of a larva of similar age by Hoechst. Note many nuclei in the pharynx.(C) The DAF-16a::GFP/bKO line grown on lophenol shows strong staining of nuclei in neurons of the pharynx, tail, and ventral cord of a dauer larva.(D) An L3 larva of DAF-16a::GFP/bKO in a daf-12 null background grown on lophenol. Note the diffuse fluorescence in the pharynx cell similar to that shown in (A). |
PMC517820_pbio-0020280-g007_511.jpg | What can you see in this picture? | Growth on Lophenol Induces the Accumulation of DAF-16 in the Nuclei of Neurons in a DAF-12–Dependent Manner(A) When grown on cholesterol, the transgenic line DAF-16a::GFP/bKO displays a diffuse staining in the cytoplasm and nuclei of many cells (only the pharynx region of an L3 larva is shown).(B) Staining of a larva of similar age by Hoechst. Note many nuclei in the pharynx.(C) The DAF-16a::GFP/bKO line grown on lophenol shows strong staining of nuclei in neurons of the pharynx, tail, and ventral cord of a dauer larva.(D) An L3 larva of DAF-16a::GFP/bKO in a daf-12 null background grown on lophenol. Note the diffuse fluorescence in the pharynx cell similar to that shown in (A). |
PMC517932_F2_517.jpg | What stands out most in this visual? | A) Location of the MVe as visualized on cresyl violet stained section and on x-ray images of parallel sections used in in situ hybridization experiments with the various oligonucleotide probes: B) H3X C) H3X blocking control D) H3A E) H3A blocking control F) H3B G) H3B blocking control H) H3C I) H3C blocking control. Sections are from a representative animal sacrificed 24 h post-lesion. Abbreviations are as follows: MVe, medial vestibular nucleus and Pr, prepositus nucleus. Scale bars are 100 μm. |
PMC517932_F2_515.jpg | What is being portrayed in this visual content? | A) Location of the MVe as visualized on cresyl violet stained section and on x-ray images of parallel sections used in in situ hybridization experiments with the various oligonucleotide probes: B) H3X C) H3X blocking control D) H3A E) H3A blocking control F) H3B G) H3B blocking control H) H3C I) H3C blocking control. Sections are from a representative animal sacrificed 24 h post-lesion. Abbreviations are as follows: MVe, medial vestibular nucleus and Pr, prepositus nucleus. Scale bars are 100 μm. |
PMC517932_F2_516.jpg | What can you see in this picture? | A) Location of the MVe as visualized on cresyl violet stained section and on x-ray images of parallel sections used in in situ hybridization experiments with the various oligonucleotide probes: B) H3X C) H3X blocking control D) H3A E) H3A blocking control F) H3B G) H3B blocking control H) H3C I) H3C blocking control. Sections are from a representative animal sacrificed 24 h post-lesion. Abbreviations are as follows: MVe, medial vestibular nucleus and Pr, prepositus nucleus. Scale bars are 100 μm. |
PMC517932_F2_519.jpg | What object or scene is depicted here? | A) Location of the MVe as visualized on cresyl violet stained section and on x-ray images of parallel sections used in in situ hybridization experiments with the various oligonucleotide probes: B) H3X C) H3X blocking control D) H3A E) H3A blocking control F) H3B G) H3B blocking control H) H3C I) H3C blocking control. Sections are from a representative animal sacrificed 24 h post-lesion. Abbreviations are as follows: MVe, medial vestibular nucleus and Pr, prepositus nucleus. Scale bars are 100 μm. |
PMC517932_F4_520.jpg | What is the main focus of this visual representation? | A) Location of the MVe as visualized at high magnification and B) at magnification used in analyses on cresyl violet stained section and C) on x-ray images of parallel sections used in [125I]iodoproxyfan binding experiments; D) non-specific binding control is represented in this image. Sections are from a representative animal sacrificed 48 h post-lesion. Abbreviations are as stated in Figure 2 legend. Scale bars are 100 μm. |
PMC517932_F4_523.jpg | What stands out most in this visual? | A) Location of the MVe as visualized at high magnification and B) at magnification used in analyses on cresyl violet stained section and C) on x-ray images of parallel sections used in [125I]iodoproxyfan binding experiments; D) non-specific binding control is represented in this image. Sections are from a representative animal sacrificed 48 h post-lesion. Abbreviations are as stated in Figure 2 legend. Scale bars are 100 μm. |
PMC517932_F4_521.jpg | What is the central feature of this picture? | A) Location of the MVe as visualized at high magnification and B) at magnification used in analyses on cresyl violet stained section and C) on x-ray images of parallel sections used in [125I]iodoproxyfan binding experiments; D) non-specific binding control is represented in this image. Sections are from a representative animal sacrificed 48 h post-lesion. Abbreviations are as stated in Figure 2 legend. Scale bars are 100 μm. |
PMC518969_F1_525.jpg | What is the dominant medical problem in this image? | Barium swallow in a patient with cystic fibrosis following right pneumonectomy. A – The study demonstrates deviation of esophagus to the right side, and a relatively horizontal lower esophageal segment proximal to the gastro-esophageal junction. B – A pancreatic enzyme capsule emptied of the enzymes and filled with barium (indicated by the arrow) is retained within the lower esophagus for several minutes. |
PMC518969_F1_524.jpg | What is the core subject represented in this visual? | Barium swallow in a patient with cystic fibrosis following right pneumonectomy. A – The study demonstrates deviation of esophagus to the right side, and a relatively horizontal lower esophageal segment proximal to the gastro-esophageal junction. B – A pancreatic enzyme capsule emptied of the enzymes and filled with barium (indicated by the arrow) is retained within the lower esophagus for several minutes. |
PMC518976_F1_528.jpg | What is the focal point of this photograph? | MRI at diagnosis (case one). |
PMC518976_F1_526.jpg | What is the central feature of this picture? | MRI at diagnosis (case one). |
PMC518976_F1_527.jpg | What is the core subject represented in this visual? | MRI at diagnosis (case one). |
PMC518976_F3_534.jpg | What is the main focus of this visual representation? | Treatment ports and dosimetry (3D). |
PMC518976_F3_531.jpg | What is the focal point of this photograph? | Treatment ports and dosimetry (3D). |
PMC518976_F3_532.jpg | What is the core subject represented in this visual? | Treatment ports and dosimetry (3D). |
PMC518976_F3_533.jpg | What is the dominant medical problem in this image? | Treatment ports and dosimetry (3D). |
PMC518976_F3_530.jpg | What is the principal component of this image? | Treatment ports and dosimetry (3D). |
PMC518976_F6_535.jpg | What is being portrayed in this visual content? | Pre-Op MR and photograph (case one). |
PMC518976_F6_536.jpg | What is the principal component of this image? | Pre-Op MR and photograph (case one). |
PMC519028_F1_538.jpg | What is the main focus of this visual representation? | Computed tomographic scan of the pelvis showing a large, well-circumscribed presacral mass |
PMC519028_F1_537.jpg | What does this image primarily show? | Computed tomographic scan of the pelvis showing a large, well-circumscribed presacral mass |
PMC519028_F4_539.jpg | What stands out most in this visual? | Microscopic appearance of the presacral mass showing a haphazard admixture of wavy Schwann cells and collagen fibers dispersed in a mucopolysaccharide matrix (Hematoxylin and Eosin, 20×) |
PMC520745_F6_543.jpg | What object or scene is depicted here? | GFP expression in ET2 line embryos is indistinguishable from endogenous PARG gene expression. 23 hpf embryos collected from a heterozygous outcross were photographed for GFP fluorescence and sibling embryos were fixed for in situ hybridization. (A) In situ hybridization with PARG antisense probe. (B) In situ with GFP antisense probe. (C) Visualization of GFP expression in living embryos using a bandpass GFP filter set. (D) The same embryo as in (C) photographed using a bandpass GFP filter set with a low level of bright field illumination to visualize GFP expression in relative position to the somites. |
PMC520745_F6_544.jpg | What is the central feature of this picture? | GFP expression in ET2 line embryos is indistinguishable from endogenous PARG gene expression. 23 hpf embryos collected from a heterozygous outcross were photographed for GFP fluorescence and sibling embryos were fixed for in situ hybridization. (A) In situ hybridization with PARG antisense probe. (B) In situ with GFP antisense probe. (C) Visualization of GFP expression in living embryos using a bandpass GFP filter set. (D) The same embryo as in (C) photographed using a bandpass GFP filter set with a low level of bright field illumination to visualize GFP expression in relative position to the somites. |
PMC520745_F6_541.jpg | What is the main focus of this visual representation? | GFP expression in ET2 line embryos is indistinguishable from endogenous PARG gene expression. 23 hpf embryos collected from a heterozygous outcross were photographed for GFP fluorescence and sibling embryos were fixed for in situ hybridization. (A) In situ hybridization with PARG antisense probe. (B) In situ with GFP antisense probe. (C) Visualization of GFP expression in living embryos using a bandpass GFP filter set. (D) The same embryo as in (C) photographed using a bandpass GFP filter set with a low level of bright field illumination to visualize GFP expression in relative position to the somites. |
PMC520751_F5_546.jpg | What stands out most in this visual? | This figure illustrates some of the pre and post x-rays taken after 4–6 weeks of treatment. |
Subsets and Splits