id
stringlengths
1
4
tokens
sequence
ner_tags
sequence
4300
[ "Results", "IBM", "was", "present", "in", "24", "%", "of", "the", "myositis", "/", "SS+", "patients", "vs", "6", "%", "of", "the", "myositis", "/", "SS-", "group", "(", "p", "=", "0.020", ")", "." ]
[ 0, 3, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4301
[ "None", "of", "the", "IBM", "patients", "responded", "to", "treatment", ",", "whether", "they", "had", "SS", "or", "not", "." ]
[ 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0 ]
4302
[ "Anti", "-", "cN1A", "was", "more", "frequent", "in", "myositis", "/", "SS+", "patients", "(", "38", "%", "vs", "6", "%", ",", "p", "=", "0.0005", ")", ",", "independently", "of", "the", "higher", "prevalence", "of", "IBM", "in", "this", "group", "(", "multivariate", "p", "-", "value", ":", "0.02", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4303
[ "Anti", "-", "cN1A", "antibody", "specificity", "for", "IBM", "was", "0.96", "[", "95", "%", "CI", ",", "0.87", "-", "0.99", "]", "in", "the", "myositis", "SS-", "group", "but", "dropped", "to", "0.70", "[", "95", "%", "CI", ",", "0.48", "-", "0.85", "]", "in", "the", "myositis", "SS/+", "group", "." ]
[ 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0 ]
4304
[ "Interpretation", "In", "myositis", "patients", ",", "SS", "is", "associated", "with", "IBM", "and", "with", "anti", "-", "cN1A", "antibodies", ",", "independently", "of", "the", "IBM", "diagnosis", "." ]
[ 0, 0, 1, 0, 0, 3, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0 ]
4305
[ "As", "a", "consequence", ",", "anti", "-", "cN1A", "has", "limited", "specificity", "for", "IBM", "in", "myositis", "patients", "with", "SS", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 1, 0, 0, 3, 0 ]
4306
[ "Background", "Target", "organ", "damage", "(", "mainly", "cardiac", "and", "renal", "damage", ")", "is", "easy", "to", "evaluate", "in", "outpatient", "clinics", "and", "offers", "valuable", "information", "about", "patient", "'s", "cardiovascular", "risk", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4307
[ "The", "purpose", "of", "this", "study", "was", "to", "evaluate", ",", "using", "simple", "methods", ",", "the", "prevalence", "of", "cardiac", "and", "renal", "damage", "and", "its", "relationship", "to", "the", "presence", "of", "established", "cardiovascular", "disease", "(", "CVD", ")", ",", "in", "patients", "with", "hypertension", "(", "HT", ")", "and", "type", "2", "diabetes", "mellitus", "(", "DM", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 3, 0, 0, 0, 0, 0, 1, 0, 3, 0, 0, 1, 2, 2, 2, 0, 3, 0, 0 ]
4308
[ "Methods", "The", "RICARHD", "study", "is", "a", "multicentre", ",", "cross", "-", "sectional", "study", "made", "by", "293", "investigators", "in", "Nephrology", "and", "Internal", "Medicine", "Spanish", "outpatient", "clinics", ",", "and", "included", "patients", "aged", "55", "years", "or", "more", "with", "HT", "and", "type", "2", "DM", "with", "more", "than", "six", "months", "of", "diagnosis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0 ]
4309
[ "Demographic", ",", "clinical", "and", "biochemical", "data", ",", "and", "CVD", "were", "collected", "from", "the", "clinical", "records", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0 ]
4310
[ "Cardiac", "damage", "was", "defined", "by", "the", "presence", "of", "electrocardiographic", "left", "ventricular", "hypertrophy", "(", "ECG", "-", "LVH", ")", ",", "and", "renal", "damage", "by", "a", "calculated", "glomerular", "filtration", "rate", "(", "GFR", ")", "of", "<", "60", "ml", "/", "min/1.73", "m2", ",", "and/or", "the", "presence", "of", "an", "albumin", "/", "creatinine", "ratio", ">", "or", "=", "30", "mg", "/", "g", ";", "or", "an", "urinary", "albumin", "excretion", "(", "UAE", ")", ">", "or", "=", "30", "mg/24", "hours", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4311
[ "Results", "2339", "patients", "(", "mean", "age", "68.9", "years", ",", "48.2", "%", "females", ",", "51.3", "%", "with", "established", "CVD", ")", "were", "included", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 13, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0 ]
4312
[ "ECG", "-", "LVH", "was", "present", "in", "22.9", "%", "of", "the", "sample", ",", "GFR", "<", "60", "ml", "/", "min/1.73", "m2", "in", "45.1", "%", ",", "and", "abnormal", "UAE", "in", "58.7", "%", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4313
[ "Compared", "with", "the", "reference", "patients", "(", "those", "without", "neither", "cardiac", "nor", "renal", "damage", ")", ",", "patients", "with", "ECG", "-", "LVH", "alone", "(", "OR", "2.20", ",", "[", "95%CI", "1.43", "-", "3.38", "]", ")", ",", "or", "kidney", "damage", "alone", "(", "OR", "1.41", ",", "[", "1.13", "-", "1.75", "]", ")", "showed", "an", "increased", "prevalence", "of", "CVD", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 3, 0 ]
4314
[ "The", "presence", "of", "both", "ECG", "-", "LVH", "and", "renal", "damage", "was", "associated", "with", "the", "higher", "prevalence", "(", "OR", "3.12", ",", "[", "2.33", "-", "4.19", "]", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4315
[ "After", "stratifying", "by", "gender", ",", "this", "relationship", "was", "present", "for", "both", ",", "men", "and", "women", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 13, 0, 13, 0 ]
4316
[ "Conclusion", "In", "patients", "with", "HT", "and", "type", "2", "DM", ",", "ECG", "-", "LVH", "or", "renal", "damage", ",", "evaluated", "using", "simple", "methods", ",", "are", "associated", "with", "an", "increased", "prevalence", "of", "established", "CVD", "." ]
[ 0, 0, 0, 0, 3, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 3, 0 ]
4317
[ "The", "simultaneous", "presence", "of", "both", "cardiac", "and", "renal", "damage", "was", "associated", "to", "the", "higher", "prevalence", "of", "CVD", ",", "affording", "complementary", "information", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 3, 0, 0, 0, 0, 0 ]
4318
[ "A", "systematic", "assessment", "of", "cardiac", "and", "renal", "damage", "complements", "the", "risk", "assessment", "of", "these", "patients", "with", "HT", "and", "type", "2", "DM", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 1, 2, 2, 0 ]
4319
[ "Objectives", "This", "study", "aimed", "to", "report", "the", "prevalence", "and", "clinical", "characteristics", "of", "adults", "with", "cerebral", "palsy", "(", "CP", ")", "in", "a", "geographically", "defined", "region", "of", "the", "UK", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 1, 2, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
4320
[ "Design", "and", "setting", "Cross", "-", "sectional", "study", "using", "the", "Northern", "Ireland", "Cerebral", "Palsy", "Register", "(", "NICPR", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]
4321
[ "Participants", "All", "validated", "cases", "known", "to", "the", "NICPR", ",", "born", "1981", "-", "2001", "and", "alive", "and", "resident", "in", "Northern", "Ireland", "at", "age", "19", "years", "were", "included", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 11, 12, 12, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0 ]
4322
[ "Results", "The", "study", "included", "1218", "persons", "with", "CP", "aged", "19", "-", "39", "years", ",", "46", "of", "whom", "died", "in", "adulthood", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4323
[ "The", "prevalence", "of", "CP", "was", "2.38", "per", "1000", "." ]
[ 0, 5, 0, 3, 0, 7, 8, 8, 0 ]
4324
[ "The", "majority", "of", "cases", "had", "spastic", "CP", "(", "n=1132/1218", ",", "93", "%", ")", "and", "could", "walk", "(", "n=949/1218", ",", "78", "%", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4325
[ "Those", "that", "died", "in", "adulthood", "typically", "had", "bilateral", "spastic", "CP", "(", "n=39/46", ")", "and", "used", "a", "wheelchair", "(", "n=40/46", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4326
[ "Conclusion", "The", "prevalence", "of", "CP", "in", "adults", "is", "similar", "to", "other", "common", "neurological", "conditions", "such", "as", "multiple", "sclerosis", "and", "Parkinson", "'s", "disease", "." ]
[ 0, 0, 5, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 2, 0 ]
4327
[ "The", "needs", "of", "adults", "with", "CP", "vary", "widely", "with", "almost", "half", "having", "two", "or", "more", "associated", "impairments", "that", "may", "require", "multiprofessional", "and", "multiagency", "coordination", "." ]
[ 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4328
[ "Results", "from", "this", "study", "can", "be", "used", "to", "inform", "transformation", "of", "health", "and", "care", "services", "for", "adults", "with", "CP", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0 ]
4329
[ "Fanconi", "anemia", "(", "FA", ")", "is", "a", "recessive", "DNA", "instability", "disorder", "associated", "with", "developmental", "abnormalities", ",", "bone", "marrow", "failure", ",", "and", "a", "predisposition", "to", "cancer", "." ]
[ 1, 2, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4330
[ "Based", "on", "their", "sensitivity", "to", "DNA", "cross", "-", "linking", "agents", ",", "FA", "cells", "have", "been", "assigned", "to", "15", "complementation", "groups", ",", "and", "the", "associated", "genes", "have", "been", "identified", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4331
[ "Founder", "mutations", "have", "been", "found", "in", "different", "FA", "genes", "in", "several", "populations", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0 ]
4332
[ "The", "majority", "of", "Dutch", "FA", "patients", "belongs", "to", "complementation", "group", "FA", "-", "C." ]
[ 0, 0, 0, 15, 3, 0, 0, 0, 0, 0, 0, 0, 0 ]
4333
[ "Here", ",", "we", "report", "15", "patients", "of", "Dutch", "ancestry", "and", "a", "large", "Canadian", "Manitoba", "Mennonite", "kindred", "carrying", "the", "FANCC", "c.67delG", "mutation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 15, 0, 0, 0, 0, 15, 16, 16, 0, 0, 0, 0, 0, 0, 0 ]
4334
[ "Genealogical", "investigation", "into", "the", "ancestors", "of", "the", "Dutch", "patients", "shows", "that", "these", "ancestors", "lived", "in", "four", "distinct", "areas", "in", "The", "Netherlands", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 15, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0 ]
4335
[ "We", "also", "show", "that", "the", "Dutch", "and", "Manitoba", "Mennonite", "FANCC", "c.67delG", "patients", "share", "the", "same", "haplotype", "surrounding", "this", "mutation", ",", "indicating", "a", "common", "founder", "." ]
[ 0, 0, 0, 0, 0, 15, 0, 15, 16, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4336
[ "Approximately", "one", "-", "third", "of", "the", "world", "'s", "population", "is", "infected", "with", "Mycobacterium", "tuberculosis", ",", "and", "it", "is", "a", "leading", "cause", "of", "infertility", "in", "endemic", "countries", "." ]
[ 7, 8, 8, 8, 8, 8, 8, 8, 8, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4337
[ "The", "global", "incidence", "of", "tuberculosis", "(", "TB", ")", "is", "growing", "at", "approximately", "0.4", "%", "per", "year", ",", "and", "much", "faster", "in", "sub", "-", "Saharan", "Africa", "." ]
[ 0, 9, 5, 0, 1, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0 ]
4338
[ "TB", "causing", "fertility", "is", "rare", "in", "developed", "countries", "." ]
[ 3, 0, 0, 0, 0, 0, 0, 0, 0 ]
4339
[ "We", "present", "a", "case", "of", "genital", "tuberculosis", "causing", "Asherman", "'s", "syndrome", "and", "resultant", "infertility", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 2, 0, 0, 0, 0 ]
4340
[ "The", "patient", "is", "a", "34", "-", "year", "-", "old", "P0", "who", "presented", "to", "care", "after", "a", "prolonged", "period", "of", "secondary", "amenorrhea", "and", "infertility", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4341
[ "She", "underwent", "a", "hysterosalpingogram", "which", "demonstrated", "no", "free", "spill", "and", "a", "diagnostic", "hysteroscopy", "which", "had", "findings", "of", "mottled", "endometrium", "." ]
[ 13, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4342
[ "Pathology", "returned", "positive", "for", "Mycobacterium", "tuberculosis", "." ]
[ 0, 0, 0, 0, 0, 0, 0 ]
4343
[ "The", "patient", "was", "treated", "with", "9", "months", "of", "antituberculous", "therapy", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4344
[ "While", "she", "has", "not", "yet", "succeeded", "in", "becoming", "pregnant", ",", "the", "patient", "has", "started", "to", "notice", "cyclic", "spotting", ",", "indicating", "possible", "return", "of", "menses", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4345
[ "This", "case", "highlights", "the", "importance", "of", "TB", "treatment", "and", "considering", "TB", "in", "patients", "who", "present", "with", "unexplained", "infertility", "." ]
[ 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0 ]
4346
[ "Recent", "expansion", "of", "arboviruses", "such", "as", "West", "Nile", "(", "WNV", ")", ",", "Usutu", "(", "USUV", ")", ",", "and", "tick", "-", "borne", "encephalitis", "(", "TBEV", ")", "over", "their", "natural", "range", "of", "distribution", "needs", "strengthening", "their", "surveillance", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4347
[ "As", "common", "viral", "vertebrate", "hosts", ",", "birds", "and", "horses", "deserve", "special", "attention", "with", "routine", "serological", "surveillance", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4348
[ "Here", ",", "we", "estimated", "the", "seroprevalence", "of", "WNV", ",", "USUV", "and", "TBEV", "in", "160", "migrating", "/", "resident", "birds", "and", "60", "horses", "sampled", "in", "Mazandaran", ",", "Golestan", ",", "North", "Khorasan", ",", "Kordestan", "provinces", "and", "Golestan", "province", "of", "Iran", "respectively", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4349
[ "ELISA", "results", "showed", "that", "of", "220", "collected", "samples", ",", "32", "samples", "(", "14.54", "%", ")", ",", "including", "22", "birds", "and", "10", "horses", ",", "were", "positive", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4350
[ "Microsphere", "immunoassay", "results", "showed", "that", "16.7", "%", "(", "10/60", ")", "of", "horse", "blood", "samples", "collected", "in", "Golestan", "province", "were", "seropositive", "against", "WNV", "(", "7", ";", "11.7", "%", ")", ",", "Flavivirus", "(", "2", ";", "3.3", "%", ")", "and", "seropositive", "for", "USUV", "or", "WNV", "(", "1", ";", "1.7", "%", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4351
[ "Furthermore", ",", "micro", "virus", "neutralization", "tests", "revealed", "that", "four", "of", "seven", "ELISA", "-", "positive", "bird", "blood", "samples", "were", "seropositive", "against", "WNV", ":", "two", "Egyptian", "vultures", ",", "and", "one", "long", "-", "legged", "buzzard", "collected", "in", "Golestan", "province", "as", "well", "as", "a", "golden", "eagle", "collected", "in", "North", "Khorasan", "province", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4352
[ "No", "evidence", "of", "seropositivity", "with", "TBEV", "was", "observed", "in", "collected", "samples", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4353
[ "We", "showed", "that", "WNV", ",", "responsible", "for", "neuroinvasive", "infection", "in", "vertebrates", ",", "is", "circulating", "among", "birds", "and", "horses", "in", "Iran", ",", "recommending", "a", "sustained", "surveillance", "of", "viral", "infections", "in", "animals", ",", "and", "anticipating", "future", "infections", "in", "humans", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4354
[ "Past", "studies", "strongly", "connected", "stool", "consistency", "-", "as", "measured", "by", "Bristol", "Stool", "Scale", "(", "BSS)-with", "microbial", "gene", "richness", "and", "intestinal", "inflammation", ",", "colonic", "transit", "time", "and", "metabolome", "characteristics", "that", "are", "of", "clinical", "relevance", "in", "numerous", "gastro", "intestinal", "conditions", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4355
[ "While", "retention", "time", ",", "defecation", "rate", ",", "BSS", "but", "not", "water", "activity", "have", "been", "shown", "to", "account", "for", "BSS", "-", "associated", "inflammatory", "effects", ",", "the", "potential", "correlation", "with", "the", "strength", "of", "a", "gel", "in", "the", "context", "of", "intestinal", "forces", ",", "abrasion", ",", "mucus", "imprinting", ",", "fecal", "pore", "clogging", "remains", "unexplored", "as", "a", "shaping", "factor", "for", "intestinal", "inflammation", "and", "has", "yet", "to", "be", "determined", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4356
[ "Our", "study", "introduced", "a", "minimal", "pressure", "approach", "(", "MP", ")", "by", "probe", "indentation", "as", "measure", "of", "stool", "material", "crosslinking", "in", "fecal", "samples", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4357
[ "Results", "reported", "here", "were", "obtained", "from", "170", "samples", "collected", "in", "two", "independent", "projects", ",", "including", "males", "and", "females", ",", "covering", "a", "wide", "span", "of", "moisture", "contents", "and", "BSS", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 13, 0, 13, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4358
[ "MP", "values", "increased", "exponentially", "with", "increasing", "consistency", "(", "i.e.", ",", "lower", "BSS", ")", "and", "enabled", "stratification", "of", "samples", "exhibiting", "mixed", "BSS", "classes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4359
[ "A", "trade", "-", "off", "between", "lowest", "MP", "and", "highest", "dry", "matter", "content", "delineated", "the", "span", "of", "intermediate", "healthy", "density", "of", "gel", "crosslinks", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4360
[ "The", "crossectional", "transects", "identified", "fecal", "surface", "layers", "with", "exceptionally", "high", "MP", "and", "of", "<", "5", "mm", "thickness", "followed", "by", "internal", "structures", "with", "an", "order", "of", "magnitude", "lower", "MP", ",", "characteristic", "of", "healthy", "stool", "consistency", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4361
[ "The", "MP", "and", "BSS", "values", "reported", "in", "this", "study", "were", "coupled", "to", "reanalysis", "of", "the", "PlanHab", "data", "and", "fecal", "1H", "-", "NMR", "metabolomes", "reported", "before", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4362
[ "The", "exponential", "association", "between", "stool", "consistency", "and", "MP", "determined", "in", "this", "study", "was", "mirrored", "in", "the", "elevated", "intestinal", "and", "also", "systemic", "inflammation", "and", "other", "detrimental", "physiological", "deconditioning", "effects", "observed", "in", "the", "PlanHab", "participants", "reported", "before", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4363
[ "The", "MP", "approach", "described", "in", "this", "study", "can", "be", "used", "to", "better", "understand", "fecal", "hardness", "and", "its", "relationships", "to", "human", "health", "as", "it", "provides", "a", "simple", ",", "fine", "scale", "and", "objective", "stool", "classification", "approach", "for", "the", "characterization", "of", "the", "exact", "sampling", "locations", "in", "future", "microbiome", "and", "metabolome", "studies", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4364
[ "OBJECTIVES", ":", "The", "incidence", "of", "neonatal", "herpes", "simplex", "virus", "(", "nHSV", ")", "infections", "is", "monitored", "periodically", "in", "the", "Netherlands", ",", "yet", "management", "and", "outcome", "is", "unknown", "." ]
[ 0, 0, 0, 5, 0, 1, 2, 2, 2, 0, 3, 0, 2, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0 ]
4365
[ "Comprehensive", "national", "guidelines", "are", "lacking", "." ]
[ 0, 0, 0, 0, 0, 0 ]
4366
[ "We", "aim", "to", "describe", "management", "and", "outcome", "in", "the", "last", "decade", "to", "explore", "current", "diagnostic", "and", "therapeutic", "challenges", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4367
[ "We", "aim", "to", "identify", "possible", "variability", "in", "management", "of", "patients", "with", "a", "suspected", "nHSV", "infection", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
4368
[ "METHODS", ":", "We", "conducted", "a", "retrospective", "case", "series", "of", "management", "and", "outcome", "of", "nHSV", "infections", "at", "2", "tertiary", "care", "center", "locations", "in", "the", "Netherlands", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]
4369
[ "RESULTS", ":", "An", "nHSV", "infection", "was", "diagnosed", "in", "1", "%", "(", "12", "of", "1348", ")", "of", "patients", "in", "whom", "polymerase", "chain", "reaction", "for", "HSV", "was", "performed", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4370
[ "Of", "the", "patients", "with", "nHSV", "infection", ",", "3", "of", "12", "died", ",", "and", "4", "of", "9", "(", "44", "%", ")", "survivors", "suffered", "neurologic", "sequelae", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4371
[ "Neurologic", "symptoms", "at", "presentation", "were", "seen", "in", "only", "2", "of", "8", "patients", "with", "nHSV", "encephalitis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
4372
[ "A", "cerebral", "spinal", "fluid", "analysis", "was", "performed", "in", "3", "of", "6", "patients", "presenting", "with", "skin", "lesions", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4373
[ "Only", "3", "of", "6", "patients", "with", "neurologic", "symptoms", "received", "suppressive", "therapy", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4374
[ "nHSV", "infection", "was", "diagnosed", "in", "8", "of", "189", "(", "4", "%", ")", "patients", "who", "were", "empirically", "treated", "." ]
[ 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4375
[ "CONCLUSIONS", ":", "Management", "of", "nHSV", "infection", ",", "particularly", "when", "presented", "with", "skin", "lesions", ",", "is", "inconsistent", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4376
[ "Many", "infants", "without", "a", "HSV", "infection", "are", "exposed", "to", "antiviral", "medication", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0 ]
4377
[ "There", "is", "substantial", "interhospital", "variation", "in", "diagnostic", "and", "therapeutic", "management", "of", "a", "suspected", "infection", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4378
[ "Comprehensive", "guidelines", "need", "to", "be", "developed", "to", "standardize", "management", "of", "suspected", "nHSV", "infection", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]
4379
[ "Purpose", "of", "review", "The", "global", "prevalence", "of", "obesity", "has", "increased", "rapidly", "over", "the", "last", "decades", ",", "posing", "a", "severe", "threat", "to", "human", "health", "." ]
[ 0, 0, 0, 0, 9, 5, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4380
[ "Currently", ",", "bariatric", "surgery", "is", "the", "most", "effective", "therapy", "for", "patients", "with", "morbid", "obesity", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4381
[ "It", "is", "unknown", "whether", "this", "treatment", "is", "also", "suitable", "for", "patients", "with", "obesity", "due", "to", "a", "confirmed", "genetic", "defect", "(", "genetic", "obesity", "disorders", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4382
[ "Therefore", ",", "this", "review", "aims", "to", "elucidate", "the", "role", "of", "bariatric", "surgery", "in", "the", "treatment", "of", "genetic", "obesity", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4383
[ "Recent", "findings", "In", "monogenic", "non", "-", "syndromic", "obesity", ",", "an", "underlying", "genetic", "defect", "seems", "to", "be", "the", "most", "important", "factor", "determining", "the", "efficacy", "of", "bariatric", "surgery", "." ]
[ 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4384
[ "In", "syndromic", "obesity", ",", "bariatric", "surgery", "result", "data", "are", "scarce", ",", "and", "even", "though", "some", "promising", "follow", "-", "up", "results", "have", "been", "reported", ",", "caution", "is", "required", "as", "patients", "with", "more", "severe", "behavioral", "and", "developmental", "disorders", "might", "have", "poorer", "outcomes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4385
[ "There", "is", "limited", "evidence", "in", "support", "of", "bariatric", "surgery", "as", "a", "treatment", "option", "for", "genetic", "obesity", "disorders", ";", "hence", ",", "no", "strong", "statements", "can", "be", "made", "regarding", "the", "efficacy", "and", "safety", "of", "these", "procedures", "for", "these", "patients", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4386
[ "However", ",", "considering", "that", "patients", "with", "genetic", "obesity", "often", "present", "with", "life", "-", "threatening", "obesity", "-", "related", "comorbidities", ",", "we", "believe", "that", "bariatric", "surgery", "could", "be", "considered", "a", "last", "-", "resort", "treatment", "option", "in", "selected", "patients", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4387
[ "The", "treatment", "of", "Graves", "'", "disease", "is", "based", "on", "three", "therapies", ":", "medical", "treatment", "with", "synthetic", "antithyroid", "agents", ",", "surgery", "and", "radioactive", "-", "iodine", "therapy", "." ]
[ 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4388
[ "The", "purpose", "of", "our", "study", "was", "to", "study", "the", "role", "and", "effectiveness", "of", "radioactive", "-", "iodine", "therapy", "for", "the", "treatment", "of", "Graves", "'", "disease", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0 ]
4389
[ "We", "conducted", "a", "retrospective", ",", "descriptive", "study", "of", "the", "epidemiological", ",", "clinical", ",", "paralclinical", "and", "therapeutic", "features", "of", "54", "patients", "with", "Graves", "'", "disease", "managed", "and", "treated", "with", "iodine-131", "as", "well", "as", "of", "their", "short-", "and", "medium", "-", "term", "remission", "rate", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4390
[ "The", "sex", "ratio", "was", "0.45", "." ]
[ 0, 0, 0, 0, 0, 0 ]
4391
[ "The", "average", "age", "of", "patients", "was", "38,33", "±", "12.7", "years", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4392
[ "The", "most", "common", "functional", "signs", "were", "weight", "loss", ",", "tremors", "and", "palpitations", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4393
[ "Mean", "FT4", "was", "54,51", "±", "19,56", "ng", "/", "dl", "(", "ranging", "from", "8,90", "and", "100", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4394
[ "Mean", "TSHus", "was", "0,074", "±", "0,29", "ÂμIU", "/", "ml", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4395
[ "Synthetic", "antithyroid", "drugs", "were", "used", "in", "49", "patients", ";", "83,67", "%", "of", "cases", "had", "persistent", "hyperthyroidism", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4396
[ "Radioactive", "-", "iodine", "therapy", "was", "used", "as", "first", "-", "line", "therapy", "in", "9,3", "%", "of", "cases", "and", "as", "second", "-", "line", "therapy", "in", "90,7", "%", "of", "cases", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4397
[ "Mean", "activity", "was", "13,29", "mCi", "±", "1,46", "ranging", "from", "10", "to", "15", "mCi", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4398
[ "The", "first", "assessment", "of", "hormonal", "status", "was", "performed", "after", "an", "average", "post", "-", "treatment", "period", "of", "1,91", "months", ";", "29", "patients", "(", "53,7", "%", ")", "achieved", "remission", "(", "eu-", "or", "hypo", "-", "thyroidism", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
4399
[ "After", "a", "12", "month", "-", "follow", "-", "up", ",", "patients", "'", "course", "was", "marked", "by", "remission", "in", "88,88", "%", "of", "cases", "(", "euthyroidism", "in", "14,8", "%", "and", "hypothyroidism", "in", "74", "%", "of", "cases", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]