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Lucknow, Nov 7: Ayodhya Deepostav 2018, an event organised to mark Diwali celebrations in Ayodhya town - has entered Guinness Book of World Records on Tuesday. A Guinness certificate was issued to UP government's tourism department and Dr Ram Manohar Lohia (RML) Avadh University, Faizabad, on Tuesday evening when over three lakh clay lamps were illuminated at Ram Ki Paidi on Chhoti Diwali as part of Deepotsava. Faizabad district will now be known as Ayodhya The event also witnessed some important announcements. Uttar Pradesh Chief Minister Yogi Adityanath said that Faizabad district will now be known as Ayodhya. "Ayodhya is a symbol of our pride. Ayodhya's identity is with Lord Ram. From today, Faizabad district's name will be Ayodhya," he said. Three lakh Diyas on banks of river Sarayu The mega Deepostav 2018 celebrations which began today with an aim to set a world record, entered the Guinness Book of Record for lighting as many as 3,01,152 earthen lamps, on the bank of River Sarayu. More than three lakh ‘diyas' or ‘earthen lamps' were lit on both sides of the banks of River Saryu. 30-feet statue of Lord Ram A massive 30-feet statue of Lord Ram was also installed on the banks of Saryu, along with that of Lord Hanuman, for Diwali celebrations in the city. Ayodhya Deepotsav 2018 The Deepotsav is an initiative by the Tourism and Cultural Department of Uttar Pradesh to celebrate Lord Rama's victory over Ravana and return to His kingdom in Ayodhya. We use cookies to ensure that we give you the best experience on our website. This includes cookies from third party social media websites and ad networks. Such third party cookies may track your use on Oneindia sites for better rendering. Our partners use cookies to ensure we show you advertising that is relevant to you. If you continue without changing your settings, we'll assume that you are happy to receive all cookies on Oneindia website. However, you can change your cookie settings at any time. Learn more

Web analytics is a fire extinguisher. Your website is on fire and you're burning cash. Instalogic can Help! Pay Per Click Advertising Company Calgary Calgary PPC Launching a new business? Looking to generate more? Pay Per Click advertising is an excellent way of driving business your way almost immediately. As the internet evolves, it is taking a larger role in our daily lives. With every passing day, we find ourselves spending more and more time in front of a computer screen. Advertisers are constantly looking for new ways to reach their potential clients. More and more of them are finding online advertising as a good tool of reaching their goals. Pay Per Click is an online advertising tool designed so advertisers can target their potential clients while those are using the search engine to find what they need. The system works by providing the advertisers with a set of tools designed to help them create their advertising campaign. The ads are displayed on a designated area called "sponsored links" in the search engine pages; those areas usually occupy the top and right side of your screen while on the search engine. Compared with conventional advertising, Pay Per Click (PPC) is very effective targeting specific audiences, unlike many other advertising channels, it also provide a reliable way of measuring advertising effectiveness. By using Pay Per Click advertising, one can target clients based on specific keywords, and keyword combinations used to perform searches online. The leading search engines with a Pay Per Click advertising program include: Google, Yahoo and MSN. Click to Enlarge Target Your Audience More Accurately Traditional advertising is designed for maximum exposure while hoping to get a response from a portion of the audience who the advertising is relevant for. With Pay Per Click, the advertiser targets it's specific audience based on keywords and keyword combinations. The advertiser's ads will only be displayed to people who searched for keywords selected by the advertiser. E.g. a pizzeria owner serving the Calgary area can set his Pay Per Click campaign so his ads will only be displayed for users searching for "Pizza" or/and "Calgary pizza". His ads will be viewed only by individuals searching for those exact terms and no one else. Traditional advertising can not offer that type of accurate targeting. Measure Your Success by Pay Per Click Advertising Service Pay Per Click advertisers can see exactly which keywords sent visitors to their site. Knowing which keywords are working for them and which are not can not only help them tweak their advertising, it can also provide them with valuable information that can help them adjust their business strategy and maybe consider offering new services based on market trends. Traditional advertising does not come close. Target Your Clients Based On Geographical Location Why advertise to a large audience when you can target your clients based on their location. Select multiple locations and change your setting at any time to test the response from new locations. Click to Enlarge Stop & Go, In Real Time In addition to setting their campaign ads to run at specific time slots, PPC advertisers can also pause and resume their campaign in real time. Other Pay Per Click benefits including real time and scheduled reporting, modifying campaign budget in real time and more.

Follow Us Timberwood Park, San Antonio, Texas Nestled in the foothills of the Texas Hill Country in San Antonio, Timberwood Park offers its residents the kind of views and peaceful calm that only nature can provide. Upon easily accessing this North-Central community from Blanco, Borgfeld, and Canyon Golf roads, its easy to see why this 2,200 acre custom home development is the ideal location. Commuting, shopping, and medical services are just around the corner with Loop 1604 just 5 short miles away, and Hwy 281 less than three. The private 30-acre park with lake, pool, clubhouse, weight room, pavilion, playground, picnic and barbecue area, par 3 golf course, green belts and unobstructed views round off this perfect place to call home. Local Agents Dan Kubinski They told me, "Dan write a Bio!".... Now who wants to talk about themselves? Well here goes: I remember being about 4 or 5 and sitting on a bench in front of a store with my older sister Karen. Picture a towheaded kid wearing one of his 4 older brothers stained, hand-me down red and white stripped shirts, with a hole over the belly button area, sporting worn cut-off shorts and a tattered pair of J.C. Penny tennis shoes, with convenient air holes for my toes to stick out. Shabby would be too kind of a word. My Sis tells it this way: Danny, you said, " Sis, someday I'm gonna be able to buy my own clothes, not hand me downs!" That was followed up with, "I'm gonna be rich Sis.... You just watch!" Its all vague now but she swears by it. Somehow, someway, I ended up doing something that I have a passion for and now over 40 years later, that passion still resides where the little determined boy once ruled my thoughts. I have been blessed with more than I ever deserved. I am rich in spirit, health and family. God has been good to that little boy from long ago, enabling me to do something I love. I am amazed and thankful every day. Fast forward a few years and envision a teenage boy in El Paso who is intent on buying 4 acres of land in Chaparral, New Mexico, on a note for $14,000. I told my family it was going to be worth much more soon. They thought I was crazy and had no business buying some land. My friends were making payments on their used Chevy Camero's, Monte Carlo's, Ford Pinto's or even 4 x 4 Ford pickup trucks, I wanted to invest in buying land. I knew it was going to go up in value soon. It did, I resold it for $19,000 just 5 months later. I was hooked and I think I even bought a new pair of shoes! That was a start of many transactions. Now, after helping over 7000 families buy or sell homes across Texas, that fire still burns deep inside me. I always have had a feeling that everything will work out! It really does when you think about it. For some reason optimism followed me like the wind, always there whispering that I could do it. You see, just as that little kid of long ago or that teenage boy full of dreams believed anything was possible, I still think I'm going to win. From those early days till now, I have been privileged and honored to have had a chance to help so many people with their real estate buying or selling needs. We have a super talented and dedicated staff to help people and without them, and of course, Tracy my wife, it would not be possible to have closed over 500 million dollars of sales in the past few years. We keep things simple. We offer, "Over the Top," service to our clients and that has been a recipe for success for us. We are truly a full service real estate office. We now even have been entrusted with government contracts from HUD, the US Marshals office, the US Attorney Generals office as well as close ties with hedge fund groups. As our client, you will receive the best we have to offer in personal service, knowledge of the current real estate market statistics, upcoming trends, home values, and expert negotiation skills. We also guide you through every step of the home buying/selling process so you will never feel alone. When you hire us, we come to work for you and will bring along years of experience and sage advice. To quote one of my favorite speakers, Zig Zieglar, "You will get everything you want in life as long as you help everyone get what they want!' Thanks for reading this and taking a look at what we are about. I thank God for what he has done for me. Dan Jonathan De La Garza No Agent Found Pilar Gonzalez No Agent Found Geoffrey Myane My family has been involved in real estate as investors, agents, renters, and advisors since before I was born. I have followed up in every role, trained by winners in the industry and successfulexperience. I do real estate because of only one reason – I truly enjoy it. I enjoy my clients getting the deal that makes them happy, and I enjoy giving fifteen percent of every commission to a nonprofit of their choice here in San Antonio to help our great city become even better. I work to find and sell properties through both traditional and contemporary options available in today’s world – online websites, MLS, mailed flyers, open houses, social media, youtube, community social events that I host, and more. Real estate is less work and more passion for me, so my phone and computer is always on and busy. No matter what you’re looking for, allow me to help you in any way I can – even if it’s just a call for advice. Rechelle Glendenning Rechelle Glendenning is an accomplished realtor and has been in real estate now for five years, one year with Crowned Eagle Realty. She has an insiders knowledge of the San Antonio area-commercial and residential market. If buying, selling or just dreaming, she places the utmost attention to service and detail. She represents buyers and sellers in any price range.

def extractStartlingSurprisesAtEveryStep(item): vol, chp, frag, postfix = extractVolChapterFragmentPostfix(item['title']) if not (chp or vol or frag) or 'preview' in item['title'].lower(): return None if 'bu bu jing xin' in item['tags']: return buildReleaseMessageWithType(item, 'Bu Bu Jing Xin', vol, chp, frag=frag, postfix=postfix) return False

'use strict'; var dbm; var type; var seed; /** * We receive the dbmigrate dependency from dbmigrate initially. * This enables us to not have to rely on NODE_PATH. */ exports.setup = function (options, seedLink) { dbm = options.dbmigrate; type = dbm.dataType; seed = seedLink; }; exports.up = function (db) { return Promise.all([ db.runSql('UPDATE office SET name = \'Office of Brazil and Southern Cone (WHA/BSC)\' where name=\'Office of Brail and Southern Cone (WHA/BSC)\''), db.runSql('UPDATE office SET name = \'U.S. Embassy La Paz\' where name=\'U.S. Embassy LaPaz\''), ]); }; exports.down = function (db) { return Promise.all([ db.runSql('UPDATE office SET name = \'Office of Brail and Southern Cone (WHA/BSC)\' where name=\'Office of Brazil and Southern Cone (WHA/BSC)\''), db.runSql('UPDATE office SET name = \'U.S. Embassy LaPaz\' where name=\'U.S. Embassy La Paz\''), ]); };

The invention relates to a discharge lamp having an oval sectional shape, and more particularly to a circular fluorescent lamp. Research and studies for developing a circular fluorescent lamp having a non-circular sectional started many years ago for the purpose of increasing the illuminance of the lamp on a plane beneath its installed position, as disclosed in Japanese Patent Publications Nos. 50-32785 (1975) and 51-11876 (1976). Also, Japanese Utility Model Publication No. 37-22455 (1962) proposes a straight fluorescent lamp in which the ratio between the larger and smaller tube diameters is selected to be 4:3 or 4:2, and the thickness of its phosphor film is made non-uniform, so as to improve its illuminance in a specific direction relative to its installation. Although a discharge tube having an oval sectional shape has been proposed for years and is well known in the art, as disclosed in the prior art publications, the mechanical strength of the discharge tube decreases inevitably due its oval sectional shape. However, no proposal has been made hitherto for solving the problem of an undesirable decrease in the mechanical strength of such a discharge tube.

Immune dysregulation in primary immune thrombocytopenia patients. To explore the immunological abnormalities in patients with primary immune thrombocytopenia (ITP), and analyze its relationship with treatment. Proportion of different immune cell subsets were detected in the peripheral blood of 124 ITP patients at different time points and 45 normal controls by flow cytometry. The treatments included glucocorticoids, intravenous IgG as first-line treatment and second-line drugs. Elevated CD4/CD8 ratio and decreased the proportion of NK and CD4 + CD25 + CD127low regulatory T cells (Tregs) were found in pre-treated ITP patients than healthy controls. The newly diagnosed group had a significantly higher CD4/CD8 ratio than the relapsed group, but no differences in the proportion of B cells, NK cells and Tregs. No relationships were found between the curative effect and the pre-treated cell subsets within both the effective and ineffective groups. Furthermore, compared with the ineffective group, the effective group had higher Tregs and lower CD4/CD8 ratio post-treatment, but no significant differences in NK and B cells. ITP patients presented with a high CD4/CD8 ratio and low levels of Tregs and NK cells, suggesting that immune deregulation was involved in the pathogenesis of ITP. The pre-treated immune status of ITP patients may not be related to the curative effect. Tregs significantly increased in the effective group post-treatment, highlighting that the mechanism of restoring Tregs may be involved in the treatment of ITP. However, whether or not the targeted regulation of Tregs is an effective treatment for ITP still requires further studies.

Effects of exhaustive exercise on biochemical characteristics of sarcoplasmic reticulum from rat soleus muscle. This study examined the effects of acute high-intensity and moderate-intensity exercise on Ca2+-stimulated adenosine triphosphatase (ATPase) activity and the Ca2+ and ATP dependence of Ca2+-ATPase of the sarcoplasmic reticulum (SR) in the soleus muscle. The rats were run on 10% grade at 50 m min(-1) or 25 m min(-1) until fatigued (avg. time to exhaustion 2.8 and 87.7 min, respectively). The catalytic activities of SR Ca2+-ATPase were significantly depressed immediately after both types of exercise. Kinetic analyses demonstrated that the Ca2+ affinity of Ca2+-ATPase was elevated by both types of exercise adopted in the present investigation whereas the increase in the ATP affinity was brought about by only high-intensity exercise. These results suggest that exhaustive exercise may induce in slow-twitch muscle fibre the environmental changes, which adversely affect SR Ca2+-ATPase activity and can overcome the positive influence arising from the increase in the Ca2+ and/or ATP affinities of SR Ca2+-ATPase.

Actinobacillus actinomycetemcomitans in adult periodontitis. I. Topographic distribution before and after treatment. The aim of this investigation was to study the topographic distribution of Actinobacillus actinomycetemcomitans in patients with adult periodontitis before and after mechanical periodontal treatment (repeated oral hygiene instructions, systematic deep scaling, and root planing). In 10 A. actinomycetemcomitans-positive patients, subgingival microbial samples were obtained from the mesial and distal aspect of every tooth (38 to 56 sites per patient, 479 sites in total) before and one month after treatment. The samples were cultured on TSBV agar. A. actinomycetemcomitans was identified based on phenotypical and serological criteria. A. actinomycetemcomitans was present in 40% of the samples taken before and in 23% of the samples taken after treatment. Before treatment, the frequency of A. actinomycetemcomitans-positive samples per patient was wide spread and ranged from 7 to 90%. After treatment, two patterns of A. actinomycetemcomitans distribution could be recognized: the majority of the patients showed only a limited percentage of positive samples and yielded less than 10(5) A. actinomycetemcomitans. In three subjects, however, relatively high numbers of positive sites were still present, and many of these positive sites showed high A. actinomycetemcomitans counts. Logistic multiple regression showed the presence of A. actinomycetemcomitans before treatment depended strongly on the individual and was significantly associated with probing depth (P < 0.001) and bleeding upon sampling (P = 0.07). The highest chance of detecting A. actinomycetemcomitans existed in deep pockets which bled upon sampling. After treatment, there was a strong individual influence and an influence of probing depth (P < 0.001). The highest chance of detecting A. actinomycetemcomitans existed in residual pockets in the range of 5 mm.

Like many others I've been creating a simple PHP/XML CMS with a wonderful tutorial on this site. Essentially it's a 'latest news' page. The stories display on the web page with the most recent item created at the top, but I want to be able to 're-shuffle' the stories based on a number I add to an XML node.I'm sure there must be a way with PHP to order the results based on a number in one of the nodes? For example: In the above example, because it has been given the rank '1', I would like it to display first on the web page no matter when it was created. Other stories with higher numbers would appear below it. Does that make sense?! Here is the php code that extracts the info and displays it on the web page:

Effects of fetal respiratory movements on the short-term fractal properties of heart rate variability. We evaluated the effect of fetal respiratory movements (RM) on the heart rate (HR) fractal dynamics.Abdominal ECG recordings were collected from low-middle-risk pregnant woman at rest. Mean gestational age was 34.8 ± 3.7 weeks. Ultrasound images were simultaneously acquired determining if RM were exhibited by fetuses. 13 pairs of HR series were compared. Each pair included 5 min of data from the same fetus either during the manifestation of RM or when there was no persistent indication of them. Detrended fluctuation analysis was applied to these series for obtaining the scaling exponent α1. HR series were also assessed using the conventional parameters RMSSD and HF power.The main findings of this contribution were the lack of significant changes in the scaling exponent α1 of fetal HR fluctuations as a result of RM. By contrast, HF power and RMSSD did show significant changes associated with the manifestation of fetal RM (p < 0.001 and p < 0.05, respectively). Yet the scaling exponent was the only parameter showing a significant relationship with the particular frequency of fetal RM (r s = 0.6, p < 0.03). Given the invariability of α1 regarding the manifestation of fetal RM, we consider that the HR short-term fractal properties are convenient for assessing the cardiovascular prenatal regulation.

Q: Integration between circle and ellipse I need to evaluate an integral over the $D=\{x^2+y^2 >1; \frac{x^2}{a^2}+\frac{y^2}{b^2}<1\}$, but I can't find the limits of integration simply by changing to polar coordinates. Thanks A: In polar coordinates, the region can be represented by a whole $2\pi$ turn of $\theta$. For the radius, it is a function of instant $\theta$ values. $\int_0^{2\pi} \int_1^{U(\theta)} F(r,\theta)*r*dr*d\theta$ where $r = U(\theta)$ can be found as follows: Suppose that a point on the ellipse has angle $\theta$, then we have $\frac{r^2cos^2(\theta)}{a^2} + \frac{r^2sin^2(\theta)}{b^2} = 1$ $\implies r^2(\frac{cos^2(\theta)}{a^2} + \frac{sin^2(\theta)}{b^2}) = 1$ $\implies r^2 = \frac{a^2b^2}{b^2cos^2(\theta) + a^2sin^2(\theta)}$ $\implies r = U(\theta) = \sqrt{\frac{a^2b^2}{b^2cos^2(\theta) + a^2sin^2(\theta)}}$

Updated to correct an editorial error in the element named in the deck. The largest industrial application of olefin metathesis today is the synthesis of propylene from ethylene and butenes^[@ref1]^ employing WO~3~ on SiO~2~, a relatively long-lived and regenerable catalyst that operates at 350--400 °C. It is widely proposed that high temperatures are required because the percentage of metal sites actually involved in the metathesis reaction is extremely low, or the reaction that generates alkylidenes is not a high yield reaction, or both. A recent paper by Copéret, Mashima, and co-workers^[@ref2]^ tackles head-on the question concerning how in WO~3~/SiO~2~ catalysts the alkylidene is formed from an olefin alone. Hundreds of papers have attempted to answer this question, although one has to admit that there may not be a single answer for all supported oxide catalysts or all olefins. Copéret and Mashima employ Me~4~BTDP to reduce four-coordinate (SurfO)~2~WO~2~ sites on silica in the absence of olefins to give 2,3,5,6-tetramethylpyrazine, hexamethyldisiloxane, and M(IV) sites ([eq [1](#eq1){ref-type="disp-formula"}](#eq1){ref-type="disp-formula"}). Analogously, five-coordinate (SurfO)~4~WO sites are also reduced to (SurfO)~4~W(IV) sites. When the purple solid containing a high percentage of W(IV) sites produced in this manner is then exposed to *cis*-4-nonene and heated to 70 °C, 1000 equiv of the alkene are metathesized in 6 h. When instead ethylene is added to the purple solid, solid-state NMR studies reveal that propene is formed along with unsubstituted square pyramidal metallacyclobutane and metallacyclopentane complexes. A variety of experiments led the authors to conclude that above 70 °C, metathesis activity can be ascribed to a relatively efficient contraction of a metallacyclopentane ring to a metallacyclobutane ring, from which loss of propylene generates an initial methylidene complex (eq 2). Ultimately, rearrangement of a metallacyclobutane complex to an olefin results in reduction to W(IV) and reformation of a metallacyclopentane and subsequently another methylidene. It is not yet known whether only TBP (SurfO)~2~W(O)(C~4~H~8~) sites undergo this "ring-contraction" to give a methylidene. "Ring-contraction" was discovered in the process of exploring reactions between tantalum(III) olefin complexes and terminal olefins to give two dimers of the terminal olefins, not metathesis products. This reaction turned out to be a good model for nonmetathetical steps in alkylidene/metallacycle chemistry of Mo and W.^[@ref3],[@ref4]^ It was recognized at the time that "the MC~4~ to MC~3~ ring contraction is a straightforward and reasonable way of forming an alkylidene ligand from olefins---assuming that some MC~3~ complexes which form in this manner will cleave to give metathesis-type products instead of rearranging."^[@ref3]^ Although unsubstituted d^0^ metallacyclopentane (MC~4~) complexes of Mo and W (especially) have been observed as the end products of a decomposition "cascade" in the presence of ethylene,^[@ref5],[@ref6]^ there is little hard evidence in homogeneous systems that alkylidenes arise from M(IV) olefin complexes^[@ref7]^ through ring-contraction of metallacyclopentanes in homogeneous metathesis reactions at 22 °C. Virtually the only exception in Mo-based or W-based olefin metathesis systems is the catalytic homologation of vinyltributylstannane to allyltributylstannane in the presence of ethylene,^[@ref8]^ which can so far only be explained through a ring-contraction mechanism. An alternative to ring-contraction as a mechanism of forming an alkylidene is a mechanism in which an allyl hydride is formed through allylic CH activation in an olefin. Allyl hydrides are intermediates in rearrangement of a metallacyclobutane to an olefin and consequent reduction of a d^0^ complex to a d^2^ olefin complex with loss of metathesis activity, so formation (to some degree) of a metallacyclobutane from an alkenyl hydride also seems feasible. The work by Copéret and Mashima may revolutionize the synthesis and use of inexpensive supported metathesis catalysts for hydrocarbons on an industrial scale by allowing the use of much lower temperatures than currently employed. It also may open up opportunities for regenerating catalysts in flow systems. However, it remains to be seen to what extent functional groups are tolerated as metathesis substrates or whether C=C bond isomerization^[@ref7]^ becomes a complication at the temperatures employed. Finally, it also must be noted that the level of selectivity found in homogeneous catalysts today^[@ref9]^ may be difficult to match in a heterogeneous catalyst since the latter are unlikely to contain true (100%) "single sites" that can be tuned with the high level of molecular precision as soluble catalysts.

Q: Execute HTTP Post automatically I have a free script and I would like to ask if it's possible to replace or automate the search function. For example every hour. Right now I have to press the search button to find new proxies but I want to search automatically and update them in my database, maybe using a cron job. if(isset($_POST['search'])) { // hit search button $script_start = $pb->microtime_float(); ob_flush(); flush(); $proxylisttype = $pb->returnProxyList($_REQUEST['listtype']); // make sure request vars are clean $sitestoscour = $pb->returnSitesScour($_REQUEST); // make sure request vars are clean $finallist = $pb->returnFinalList($sitestoscour); $finallist = $pb->arrayUnique($finallist); // eliminate the dupes before moving on if(AUTO_BAN == 1) { // remove banned proxies $finallist = $pb->autoBan($finallist); } $script_end = $pb->microtime_float(); // stop the timer } A: You can either do it with curl from a php script or command line (or wget). That way you can set the $_POST: $ch = curl_init(); curl_setopt($ch,CURLOPT_URL, "http://yoururl.com'"); curl_setopt($ch,CURLOPT_POST, true); curl_setopt($ch,CURLOPT_POSTFIELDS, "search=your_query"); $result = curl_exec($ch); curl_close($ch); Then make that script run every hour by setting up a cron job. You could also do it with wget: wget --post-date="search=query" http://yoururl.com

Follow me on Thursday, 29 March 2012 This is a card I made for my friend Eileen who's birthday it is today.....Happy Birthday Eileen...I just love this S.U. Elements of Style stamp set. Coloured with Copic pens and I have 3D some of the flowers.Card, papers and the embossing folder are all from Stampin Up...just added a touch of glittered lace and a few pearls. Saturday, 24 March 2012 This is an image from the Oh La La CD Carnival of Colours which has some beautiful images and is lovely to use especially when you need a quick card.For part of the background I have stamped an S.U. script background a onto old olive card. Leaf branch is also from S.U.....faux brads added. Wednesday, 21 March 2012 The challenge over at Penny Black this week is 'This, That and the Other (Anything goes). Haven't had time to craft since Friday as we have been baby sitting but managed to produce this card for the challenge.Stamped image is called 'Sweet surprise' and coloured with Copics.Backing paper is from my stash but I know the yellow paper is from Papermania.Sentiment is Personal Impressions stamp... Sunday, 18 March 2012 Firstly Happy Mothers Day to every mum out there in blogland....I hope you are all being thoroughly spoilt today. This is also my mid month post for St Lukes charity card challenge and our challenge was Spring into Spring.My stamp is an old one and although is wood mounted does not have a name on it....this stamp really needed to be 3D to make the tulips stand out...image was embossed with copper and then painted with some Daler-Rowney Pearlescent Liquid Acrylic paints which I have had since the year dot!Corner dies are from Cuttlebug... sentiment is stampin up. You still have time to make your Spring into Spring creation...and we are hoping we might top 100 entires this month...so come on crafters help us reach our target.Have a lovely day..... Saturday, 17 March 2012 She's a wonderful daughter and a fantastic mum. Martin her husband is taking her away for a couple of days and we are looking after the children, we are having a family meal today which will be lovely... Friday, 16 March 2012 I love these sets where you get stamps and dies together although I have just used the die cuts on this Die-Namics set, its does save you having to cut out the images! I have used a tiny stamp from the set on the background behind the tea pot. Backing papers is S.U.....just added a little bit of lace for the tablecloth and made some faux brads.Hope you all have a great week end whatever you do.. AnneI've just noticed the word tea is upside down..so had better change that!! Thursday, 15 March 2012 I've been playing with my S.U. Fresh Vintage stamp set.Stamped the main image using old olive and also stamped the larger flower stamp using real red and 3D the flower head. Mounted onto Nesties. For the background I used S.U. designer paper which matches the stamp set and one of the S.U. embossing folders. I used 2 of the small butterflies from the S.U. Butterfly Sizzlet die.We have thick fog again here in Somerset and it quite cold so think today could be a crafting day....well who needs an excuse to craft!! Wednesday, 14 March 2012 Ok I know its the same image as yesterdays post but haven't got another card to post today so thought you might like to see the Baby Boy version of yesterdays card.Image is from Sugar Nellie called 'Bambino'....coloured with Copic pens...backing papers are all from S.U., sentiment from LOTV.....S.U> eyelet punch. Embellishments from my stash. Think my daughter will happy with the baby cards.Its our club night tonight and we stamping onto candles with Michelle and doing a parchment project with Janet....hopefully if I remember I will take my camera tonight and take some photo's. Tuesday, 13 March 2012 Two posts in one morning!!! I've finished the first baby card for my daughter and I've used this lovely image from Sugar Nellie called 'Bambino'.....coloured with copic and mounted onto Nesties. Again I have used some gathered ribbon around the edge. Backing papers are from S.U. The little silver flowers are buttons which I have had for ages. S.U. eyelet border punch and of course a few pearls.... Right off to make a the baby boys card now...which I will post tomorrow!! Another 'quickie' LOTV card for you this morning using the die cuts....love these two little chaps... Papers are from K and Co Hopscotch pad...MS border punch and Su star punch...Off to make a couple of baby cards for my daughter, her friend is having a C.Section next week and of course they don't know what sex the baby is so need to make one of each.... Monday, 12 March 2012 I am still plodding on with my 60 card order...nearly there now just Wedding and a few mens cards to do...This is one of my 'quickie' cards using one of the lovely LOTV die cut images which I have added more colour to. For some reason the colours haven't colour come out very well...I used Copics next time I will use pencils and hopefully that will be better...Anyway back to the card...backing paper is from S.U. so is the cardstock, Nestiies die, E.K. Success scallop border punch, sentiment is from Craftwork Cards...Thanks for popping by... Sunday, 11 March 2012 Another great challenge this week from Chrissie and Mandi over at Less is Moreits One Layer and the subject is Script.I've used two stamps, one script one if from Hero Arts called Manuscript Background and the lady is a Rubber Stampede stamp and is just called 'Woman in a Hat'. I stamped the lady first then masked her before popping the script stamp over the top.The weather here in Somerset is a bit foggy and overcast so an ideal day to spend in the craft room!Enjoy your Sunday... Saturday, 10 March 2012 Our challenge over at the Penny Black Saturday challenge this week is 'The Young Ones'.... This is one of my cards that I made for my big order so thought you would fit this challenge has you cant get any Younger than a baby!Colours with Copic pens. mounted onto circles with a touch of pink lace around. Backing paper is from Craft Creations, embossing folder used is from S.U.Sentiment is an Art Impressions one...Think my scanner is giving up the ghost as it wont copy very well so will have to get my camera charged up! Thursday, 8 March 2012 This weeks challenge over at Less is More is Colours and the colours we have been given to use are Neutrals...Mandy and Chrissie have given us some lovely inspirational cards... I have used the Stampin UP Triple Treat Flower which I bought a while ago..stamped the flower in Black and Soft Suede. Backing papers are also from S.U. and so is the border punch and the sentiment, Just added a little black ribbon across the centre. Wednesday, 7 March 2012 I have been lucky enough to receive this lovely award from Pauline over at Craft Obsession so thank you Pauline very much.So, to accept this award there are a few rules:Thank the giver and link back to the blogger who gave it to you.Reveal your five blogger picks and let them know by leaving a comment on their blog.Copy and paste the award on your blog.Hope that those you honour forward it to their favorite bloggers.Here are just 5 ladies who visit on a regular basis, and provide a lot of inspiration when the old mojo is lacking but I could add a lot more to my list.... Sunday, 4 March 2012 Penny Blacks challenge this week is CASE-IT and this is my take on the challenge.I've used my Butterfly Kitty stamp and coloured it with Copic Pens.Flower punch is one of the Nellie Snellen ones, Senitment and punched label is from Stampin Up.My lovely friend Val and her husband come to visit on Friday and we always have a bit of a 'show and tell' of our crafty things we have done and Val very kindly let me use one of her new Go Kreate dies which was a scallop circle which just about went through my Bigshot..so thank you Val.Easel cards aren't the easiest of cards to photograph thats why I dont put many on my blog!! Thursday, 1 March 2012 Where did February go to?? Its the 1st of the month and that means another challenge over at St Lukes Charity card challenge and this month our challenge is Spring into Spring...anything to do with Spring....flowers, animals, fresh Spring colours so lets see what you can come up with.The stamp I have used is an old PSX Clematis stamp, coloured with Prismacolor pencils, backing paper is from Stampin Up the Trellis punch us a Martha Stewart one, leaves punched are from the SU bird punch.We have two great giveaways this month so if you enter a card you could win this lovely set of Waltzing Mouse stamps and a great magazine Paper Crafts for lots of inspiration: Pop over the the St Lukes Challenge blog and see what the other members of the DT have come up with for this challenge.....wouldn't it be great if we would reach 100 entries this month, so come crafters show us what you can do. Follow this blog with bloglovin Followers Translation Follow by Email About Me My name is Anne I have been a crafter for many years but making cards for 18 years. My friend Karen and I started a Craft Club in a little village in Somerset 11 years ago.I have the best hubby in the world', 2 lovely daughters and 4 beautiful grandchildren, who could ask for more?

The Bauer Memorial Path provides a short route through residential and commercial areas of Machesney Park, a northern suburb of Rockford. The trail begins at the Harlem Community Center and travels in... The Busse Woods Trail system is located within Ned Brown Forest Preserve, a 3,700-acre property in the northwestern suburbs of Chicago. There are 11.2 miles of paved trails for cyclists, equestrians... The Cal-Sag Trail (or, Calumet-Sag Trail) is currently under active construction. As of early 2018, it has a competed section of about 13 miles, stretching from near its western terminus at the John... Illinois’ Centennial Trail runs through parts of three suburban counties from Willow Springs Road to Romeo Road/135th Street southwest of Chicago. The trail occupies a thin strip of land between the... The Chain O' Lakes Bike Path is a paved trail that runs between E. Grand Avenue in Fox Lake and Grant Woods Forest Preserve to the east. The trail parallels the railroad track and Rollins Road/CR 31,... The Charles Street Community Path offers a neighborhood route through southeastern Rockford, connecting residents to CherryVale Mall on its eastern end. On its western end, Alpine Park is just north... The Commonwealth Edison Bikeway is a short paved trail that occupies an overhead electric utility corridor owned by Commonwealth Edison, the local utility company—hence the trail's name. While lacking... The DeKalb-Sycamore Trail—also known as the Peace Road Trail—parallels the eastern side of Peace Road from DeKalb to Sycamore in northern Illinois. Along the way, you'll pass a mixture of residential... The Deer Grove Trail is one of several great Chicagoland trails located in properties of the Forest Preserve of Cook County. Deer Grove is the oldest of all the Cook County preserves. It's comprised... The Duck Lake Nature Area Trail follows the southern side of Lake Como between Lake Geneva and Como, Wisconsin, not far from the Illinois state line. The trail is more rustic than most rail-trails and... The East Northbrook Trail is a 1-mile route through a wooded corridor adjacent to an out-of-service rail corridor in the Village of Northbrook. The trail provides access to residential neighborhoods,... The the Fox River Trail (FRT) was built on stretches of three former railroads: Chicago, Aurora & Elgin; Aurora, Elgin, & Fox River Electric; and Chicago & North Western. Today, it hosts a multitude... About an hour northwest of Chicago, the beautiful Grant Woods Forest Preserve spans more than 1,000 acres, offering an outdoor respite of prairie, woodlands and marshes. The crushed limestone pathway... The eastern segment of the Great Western Trail in Illinois follows 12 miles of an abandoned railway corridor through DuPage County, between Villa Park and West Chicago. There are plans to extend the... The western segment of the Great Western Trail in Illinois follows 17 miles of a former railway corridor through DeKalb and Kane counties, between LeRoy Oakes Forest Preserve and the town of Sycamore.... The Harlem Township Bike Path lies not far from the Rock River in western Machesney Park in the Rockford metropolitan area. The trail consists of a lower (southwest) and an upper (northeast) loop in... The Hononegah Recreation Path begins near the State Route 2 bridge over the Rock River in Rockton, a small town about 4 miles south of the Illinois–Wisconsin border. The paved trail follows Hononegah... The John Husar I&M Canal Trail is the northernmost trail developed on the Illinois & Michigan Canal National Heritage Corridor. The Illinois & Michigan Canal provided the final link in the water route... The Joliet Junction Trail is a paved path that travels north–south through the west side of Joliet. It occupies an abandoned Elgin, Joliet and Eastern Railway corridor that in its last years was known... The KR Trail is a new addition to Kenosha County’s growing bike-ped network. The trail picks up where the Kenosha County Bike Trail leaves off, in Petrifying Springs Park. From the northwest corner of... The Kishwaukee Riverfront Path winds nearly 7 miles through downtown Belvidere, east of Rockford in northern Illinois. As its name implies, the paved scenic trail follows the waterway for most of its... The Kishwaukee-Kiwanis Trail winds through the northern Illinois town of DeKalb, coursing along a river, through woodlands, among open spaces through parks and through suburban back yards. The trail... The Kuhn Road Trail starts on Lies Road, at Glenbard North High School and continues south along Kuhn Road, past single-family homes and Friendship Park. The trail officially ends at Barbara O'Rahilly... The 13.5-mile Lake Michigan Pathway keeps you in close touch with the sixth-largest freshwater lake in the world as it links rail-trails north and south of the port city of Racine. Along the way, the... Although a relatively short trail, the Leland Path provides an important connection between the Hononegah Recreation Path and the Stone Bridge Trail. The pleasant, tree-dotted pathway travels through... The Millennium Trail currently spans just over 30 miles in two disconnected segments, but there are plans to extend it to 35 miles and connect it to the Des Plaines River Trail. The trail goes through... The North Branch Riverwalk is a 0.6 mile biking and walking trail located on Chicago's northside along the North Branch of the Chicago River, nestled between Gordon Tech High School and Lane Tech High... The North Branch Trail follows the North Branch of the Chicago River over 20 miles through Cook County. The trail was originally a dirt path often used for horseback riding; though it’s now paved, an... The North Shore Bike Path runs for nearly 8 miles between Lake Bluff and Mundelein, paralleling State Route 176 for the path's entire length. The trail is one of dozens in the Chicagoland area, all of... The North Shore Channel Trail extends from the junction of Green Bay Road and McCormick Boulevard in northern Evanston to the junction of Lawrence Avenue and Francisco Avenue in Chicago. All but the... Racine’s southeastern neighborhoods are home to the North Shore Trail, which extends south to the Racine–Kenosha county line. Because Racine County standardized its signs several years ago, you won't... The Orland Park Bikeway provides a great connector across the Chicago suburb of Orland Park. On its southern end, the trail begins at W. 159th Street and winds its way through Centennial Park, which... Stretching from Afton to Janesville, the northern section of the Peace Trail offers a paved, tree-shaded route paralleling the Rock River and an active rail line. At its northern end, the trail merges... The Pelishek-Tiffany Nature Trail runs for 6 miles along an abandoned railroad corridor, between the towns of Allens Grove and Clinton. The trail is open to snowmobiles, cyclists, horseback riders and... The Perryville Path runs nearly 7 miles, connecting the communities of Loves Park and Rockford, not far from the northern border of Illinois. A pleasant place to begin your journey is Rock Cut State... The Pike River Pathway is a short trail on both sides of the reconstructed Pike River in the Village of Mount Pleasant. The path is convenient to several neighborhoods in the community. Birds, frogs... The Prairie Point Trail is a scenic neighborhood route that connects twice to the longer Grove Road Trail. While never far from houses, the trail offers surprising scenery, including a stretch along a... Prospect Heights has very few sidewalks, so biking, inline skating or walking are moved to the streets or in the parks. Don't underestimate the Prospect Heights Bike Path which is over four miles of... The Puri Path is a paved route in Rock Cut State Park, a beautiful outdoor destination of more than 3,000 acres for the city of Rockford. The path runs through the heavily wooded northeast corner of... The 4.4-mile River Bend Trail is so named for the loop of Fox River along which it follows on its eastern end. It's here that you can connect to the scenic Fox River Trail to travel 43 miles along the... The Robert McClory Bike Path runs the length of Lake County, knitting together a string of communities on the north shore of Chicago all the way to the Wisconsin border. In 1997, the trail was named... The paved Rock River Recreation Trail winds throughout downtown Rockford and environs, following the east bank of the Rock River through Shorewood Park and Martin Memorial Park. Officially, the trail... The Rock Valley College Path is a paved route looping around and through its namesake campus in Rockford. At its southern end, it connects to the Spring Brook Road bike lanes that continue east to the... An excellent example of land use in greater Chicago, the entire Skokie Valley Trail corridor is a rail-with-trail, paralleled by double tracks that sit about 40 feet to the west of the trail surface.... The Southern Dupage County Regional Trail connects multiple of the larger forest preserves in Dupage county together. Starting near the intersection of 75th st and Ogden Ave in Aurora, the trail runs... The Stearns Road Bike Path is a dedicated sidepath traveling from Hanover Park to the Bartlett, in the Chicago suburbs. The asphalt path sits on the north side of Greenbrook Boulevard/ Stearns Road,... Built on a former rail bed dating back to the 1850s, the Stone Bridge Trail provides a crushed limestone pathway through rural countryside. A highlight of the trail is passage on Stone Bridge over the... The Struckman Boulevard Path is just over a mile long, stretching between Bartlett Road and State Route 59, (although the path narrows from the end of Sunset Park up to the end on SR 59). That said,... The Tall Grass Greenway Trail is a trail that runs along the right of way for ComEd powerlines. The trail goes mainly through neighborhoods in south Naperville, and meets up with the south branch of... In just a few short miles, the Wauponsee Glacial Trail leaves the urban confines of Joliet to bask in open farmland and reclaimed tallgrass prairie where the bison roam again. Named for a glacial lake... Recent Trail Reviews Kinstone Recreational Path Side trail that leads to others It seems to me this should have been called the Hononegah Trail given it passes through the forest preserve and etches the road with the same name. Anyways, the far east part of this path stems off of the Old Bridge Trail which is a great place to bike. When you come off that trail and onto the Kinstone, you go through a small forested area before heading up a hill that starts you along Hononegah Rd. The trail is asphalt/cement and is in pretty good shape. As mentioned, it goes through the front section of the Hononegah FP where they have a bathroom, picnic tables and a water pump all near the trail. The trail ends just east of downtown Rockton but another path picks up that takes you past the Rock River and the downtown area. There aren't many bells and whistles along this short path but it is a nice continuation to other trails in the area. Stone Bridge Trail Continue the Long Prairie Trail A month or so ago I rode the full length of the Long Prairie Trail. When I reached the Ronald Olson FP I realized that the trail continued as the Stone Bridge Trail. Having liked the Long Prairie Trail I marked the path for a future visit. That didn't take long, I was back a month later and ready to tackle the Stone Bridge and four other paths in the area with my son. The Stone Bridge Trail is a very well kept limestone trail that only spans about 6 miles. Although short it features areas where you are in a gorge, then on a steep hill. In the middle you can get a history lesson by demounting and walking down the hill at the Stone Bridge site. At the base of the hill you can see the preserved site and read about its historic value. At the northern base of the trail you can see where the train track line continues north. I sincerely hope they turn this into more biking trail that heads into Wisconsin. Waterfall Glen great ride We rode the main trail and explored a few trails leading off the main trail on our mountain bikes. The only complaint is the lack of water. We are going back in a couple of days to do two loops and try more side trails. We will bring a cooler with our supplies Pecatonica Prairie Trail On the decline I've used this trail for years. The past couple have seen serious decline in the trail's condition. It once was nicely and evenly packed with crushed gravel as recent as three years ago, but now most of it has been overtaken by grass and heavy rains have washed out parts of it. It's still passable on mountain bikes and fat tire bikes, but that's about it. I'm not sure why it has stopped being maintained but at the current rate, in another year or two nature will take it back completely. Fermilab Trail Good ride, Kirk Road is a mess We came thru off of Batavia Rd and was an easy no traffic ride. Easy loop back to Prairie Path Trail. Headed north on Kirk and is under construction and west side bike trail is terrible going up to Faybian Pkwy. Fox River Trail (IL) Oswego to Algonquin and back We’ve spent many hours on this trail since we started riding a tandem two and a half years ago. We live close the Virgil Gilman trail in Sugar Grove and have spent most of our time on the southern half of the Fox River trail north and south of its junction with the Gilman Trail. The Fox River Trail also connects with the Illinois Prairie Path and its spurs as you venture north of Aurora through Elgin. Six weeks or so ago we decided that we would try to ride the entire length of the trail and back. We spent the last couple of weeks on the northern section of the trail making sure that we knew our way through the northern half which has a few sections that go around short breaks in the paved trail such as north of State Street in South Elgin and heading south into South Elgin where the trail meets Raymond Street, there is also a junction to the Elgin spur of the Prairie Path. If you cross Raymond Street, you’ll be on the Prairie Path which you can use to go around South Elgin. To stay on the Fox River Trail, do not cross Raymond – go around the corner to the right. Each of these practice runs also included the hilliest section of the trail between South Elgin and Batavia. Tandems are crazy fast downhill due to the mass and aerodynamics but riding up long hills takes a special kind of love! Yes, the trail can be busy around the towns; especially on weekends. The same reasons we are attracted to this trail also brings out the people walking and families. We thought doing our end to end ride would be better on a Friday but there were a surprising number of folks enjoying the beautiful day with us. We’re just patient with passing and give a thank you as we go by. More so than some other trails, there are many surface crossings so this trail will not boost your average speed, but we find these limitations to be a reasonable trade-off for this well-maintained trail. The ride yesterday was generally incident free and went according to plan and was our longest ride to date on the tandem. We started out with a rear derailleur skipping issue which was very annoying (you shift more on a tandem than a single) but a quick adjustment at our first rest stop and all was well. The only other issue was a bridge replacement over Poplar Creek just north of South Elgin. Last Sunday there was no sign of construction, but we approached yesterday to find the trail closed. We checked it out to find that the old bridge had been removed but the new one was not yet installed. Fortunately, we found an unofficial detour and continued. Southbound, there was a sign that indicated the trail would be closed through the end of the month. Cal-Sag Trail Beautiful trail, no street crossings!! Loved exploring this trail today! A bit hillier than Prairie or Salt Creek but nice rolling up and down both ways. We easily found Sag Quaries with Google Maps off of 83 and jumped right on. Couldn't believe no street crossings all the way to Nicks BBQ at the end of the trail! We stopped for lunch than headed back. Nice 24 miles! Loved the Lake Katherine area and the low traffic on this trail! We'll do it again in the fall as the foliage will be beautiful! Danada and Herrick Lake Regional Trail Herrick Lake - A Little Gem in Western DuPage County I am embarrassed to admit that I have lived in the area for 20+ years and have driven by this little gem more times than I can remember. It is gorgeous!! I took my bike and was amazed at the number of trails and how large the area is. I went on a weekday afternoon so while many people were there walking their dogs or just enjoying the solitude, it never felt crowded. There were many stretches where I was completely alone and had the trail to myself. The parking lot of the Herrick Road entrance can accommodate many cars. It's a great oasis in the Western suburbs and I can't wait to go back!! Prairie Trail (IL) Awesome Path! August 7th. Almost a perfect summer day and definitely perfect for a ride. Did a 30 mile round tripper from just south of Wisconsin line to south of McHenry and back. Condition of trail for that portion was about the best I've ever seen on any trail. Highly recommend parking at the trailhead for the Hebron Trail off Keystone Road at the north end of the trail. Hebron Trail will then take you straight east to hook up with Prairie Trail where you can begin and head south. No problems, well maintained all the way. Passes through several small, medium sized towns on this stretch with McHenry being the biggest. Plenty of access to services, food, water if you need it. Plan is to continue from McHenry on down south for my next leg of this trail. Can't wait to see what's ahead. Baumann Park Recreation Path Very Nice Fox River Trail (IL) Best sights of any bike trail! This bike trail has the best sights of any! In Batavia you have the huge windmill, Fabyan Japanese gardens, and trolley museum. Pretty wildflowers as you go through Saint Charles and pass Camp Kane. The train museum in St Charles is neat as well as the collection of signals with the Woodcliff sign, then once you get to Elgin you can see a little castle off the path, Pratt's castle! I don't think any other path has as cool sights as this one.

Q: Default context menu for RichTextEdit? There doesn't seem to be a default context menu (with copy, paste, etc.) for the RichTextEdit control in WinForms? I try right-clicking inside the RichTextEdit and nothing happens? A: Correct. The RTE control doesn't have a default context menu. But you can assign it your own.

Control of neonatal pulmonary vascular and airway resistance remains poorly understood. Recently, two additional intrapulmonary control systems, pulmonary neuroendocrine cells (PNEC) and the pulmonary peptidergic innervation (PPI), have been described, which may influence pulmonary vascular and airway tone in the neonate. PNEC are granulated cells that line the airways of fetal, neonatal, and adult lungs. They are particularly numerous in the neonatal period and contain peptides (bombesin, calcitonin, leu-enkephalin) and amines (serotonin) known to affect smooth muscle tone in other organ systems. The PPI, composed of fibers containing substance-P and vasoactive intestinal peptide (VIP), have been described in association with pulmonary airways and vessels of all sizes. Both these peptides are known to profoundly influence smooth muscle tone in other organ systems. Limited indirect anatomic and physiologic evidence has suggested a role for both systems in altering intrapulmonary smooth muscle tone, particularly in neonates; however, basic knowledge of both systems is extremely limited. The aim of this research program is to provide some of the fundamental knowledge necessary to assess the role of both these systems in influencing neonatal pulmonary vascular and airway tone under normal and pathologic conditions. This aim will be accomplished in the following fashion: (1) Determination of the development and distribution of PNEC and PPI within the lung using immunohistochemical techniques. (2) Determination of the anatomic distribution and number of receptors for the above peptides and amines, and their relationship to receptors for the presently characterized intrapulmonary control mechanisms (adrenergic and cholinergic innervation) using redioautography. (3) Determination of pathologic alterations in the structure and distribution of PNEC, PPI, and adrenergic, cholinergic, and peptidergic receptors in (a) experimental asthma and (b) acute and chronic neonatal cardiopulmonary disease where alterations in vascular and airway tone are either known to play a significant role (hyaline membrane disease, bronchopulmonary dysplasia, congenital heart disease) or may play a significant role (sudden infant death syndrome, cystic fibrosis). Should these two systems, pulmonary neuroendocrine cells and the pulmonary peptidergic innervation, influence neonatal vascular and airway tone; understanding their normal function and their alterations in common neonatal cardiopulmonary pathologic states may lead to novel therapies for a number of currently untreatable, or poorly treatabale, neonatal cardiopulmonary diseases.

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Rajki Rajki is a village in the administrative district of Gmina Bielsk Podlaski, within Bielsk County, Podlaskie Voivodeship, in north-eastern Poland. It lies approximately south of Bielsk Podlaski and south of the regional capital Białystok. See also Béla Rajki, Hungarian swimming coach and water polo coach References Rajki

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is needed. Air conditioners are rated according to energy output, measured in BTUs. Simply put, the larger the room, the more energy output required. One more important point: Modern equipment is more energy efficient than older models. New Energy Star–rated models use 10 percent less energy than conventional models. These new-gener-ation air conditioners often have timers to turn down the power when it’s Hot tips for not needed. Smart usage tips Once you have the keeping cool right air conditioner in place, AHAM suggests following these tips to optimize performance. • Turn off the unit and open doors and windows during cooler periods. • Use the unit fan and portable fans to draw in cooler outside air and increase circulation. • Use a dehumidifier in the basement to prevent excess moisture seepage through the house. • Use a higher (warmer) thermostat setting during peak periods or when the area is unoccupied. A 75- to 80-degree setting will cut power consumption by 15 percent. • Don’t let heat build up all day and then try to cool areas quickly. Start units earlier in the day and cool areas slowly before they are occupied. • Avoid activities that generate high heat and humidity (such as cooking, bathing and laundering) during high-heat hours. • Draw shades or window blinds to reduce solar and outdoor heat. Reflecting and dou-ble-pane glass, awnings, overhangs, louvered sunscreens, plantings, fences or an adjoining building also help—but don’t block the back of the air-conditioning unit. • Regularly change or clean filters and check airflow for blockage or frost on the evaporator coil. • Have the air conditioner checked and cleaned at the start of the season. During the off-season, make certain it is cleaned and properly covered and disconnected.—Tim Talevich KEEPING COOL in your home or business in the summer months can roast your energy bill. But taking energy-smart steps can help keep air-conditioning costs as low as possible. The two keys are buying the proper air conditioner and running it properly. Here’s a primer. Buying the right air conditioner It’s easy to understand how an undersized air conditioner won’t properly cool a room. Units that are too small simply aren’t strong enough to cover a large room. However, an equally common mistake is having an air conditioner that is too large. Air conditioners remove both heat and humidity from the air, explains Energy Star, a federal government organization that promotes energy-efficient products and practices. “If the unit is too large, it will cool the room quickly, but only remove some of the humidity. This leaves the room with a damp, clammy feeling. A properly sized unit will remove humidity effectively as it cools.” Determining the right size of an air conditioner involves calculating room size and other factors. Energy Star offers a basic chart to calculate these figures on its Web site at www.energystar.gov/index.cfm?c=roomac.pr_ properly_sized. But a more detailed calculator is offered by the Association of Home Appliance Manufacturers (AHAM) at its site, www.cooloff.org. This program asks for information on which region you live in, whether the room has windows (and which direction they face), what’s above the room and so on. Either way, once you establish room size, you can determine what size air conditioner • EnergyStar certified for high energy efficiency • Electronic controls (including remote control) • High power cooling and low noise operation • Washable air purifying filter (anti-bacteria filter) • Effective dehumidifying operation • Indoor temperature sensing thermostat • Energy saving switch • 24-hour On/Off timer • Window kit for easy installation The Costco Connection Costco offers a variety of air conditioners from leading manufacturers in the warehouses and at costco.com.

2007 to be hottest year ever, says Met Office The UK's Meteorological Office predicts that 2007 will be the hottest on record, due to a combination of global warming and the El Niño weather phenomenon, Reuters reports. This year will, the Met Office and prediction partner the University of East Anglia say, top the current record set in 1998. 2006, meanwhile, currently lies sixth in the all-time hottest years globally chart. All ten of the hottest years during the last 150 (when records began) have occured since 1994, the UN's weather agency adds. Specifically, the upshot is that the world's average temperature in 2007 will be "0.54 degrees Celsius above the 1961-1990 long-term average of 14.0 degrees". 1998 clocked up 0.52 degrees above said average. Met office scientist Katie Hopkins said: "This new information represents another warning that climate change is happening around the world." The long-term prognosis is alarming. As Reuters puts it: "Most scientists agree that temperatures will rise by between two and six degrees Celsius this century due mainly to carbon emissions from burning fossil fuels for power and transport." ®

A typical tire has a plurality of rubber components and a plurality of reinforcing components chiefly constituted by cords. As illustrated in FIG. 9, a typical example of the tire includes an inner liner 1, a tread 2, side walls 3, rim strips or chafers 4, under-belt pads 5, and other components, all of which are built by rubber materials having required characteristics. These rubber components are combined with a carcass layer 6 and a belt layer 7 as reinforcing components including cords to become a tire T. FIG. 8 illustrates an example of respective disassembled components of a tire. FIG. 8 shows the inner liner 1, a tread base 2a and a tread cap 2b constituting the tread 2, the side walls 3, the chafers 4, and the under-belt pads 5 laminated under both side ends of the belt, all of which are built by rubber materials having predetermined characteristics. The carcass layer 6 has first and second carcass plies 6a and 6b, and the belt layer 7 has a plurality of belts 7a and 7b. Each of bead members 8 has a bead core 8a made of wire or the like and a bead filler 8b made of rubber attached to the outer circumference of the bead core 8a. A squeegee 10 as a rubber layer laminated on the inner ply, tapes between plies 6c, belt edge tapes 7c are all made of rubber materials. A spiral tape 9 contains fiber cords. A double-stage building method is known as a method for building this type of tire. According to this method, the inner liner, the carcass ply and other components are affixed on an expansive and contractive band drum, and the beads and sides are built by a primary building drum to build a green case. The green case is shifted to a secondary building drum which modifies shaping to build the green case into a toroidal shape, onto which the belt, the tread rubber and other components are affixed to build a green tire. In addition, a single-stage building method which uses a single building drum swinging between the position at which both the band building and primary building are executed and the secondary building position is known. When the tire components in the respective processes are affixed and built at a different building position for each of the primary building step and the secondary building step in the double-stage building method, longer building cycle time is required and therefore improvement of productivity is difficult to achieve. As a technique for overcoming these drawbacks, a system which uses a plurality of movable building drums to build a green tire has been proposed. In this system, the movable building drums are shifted to predetermined building positions. Predetermined components such as an inner liner or other rubber components or carcass plies are supplied to build a green case in a primary building step, and rubber components such as a belt and a tread are supplied to build a green tire in a secondary building step. The system which shifts the building drums to execute the double-stage building method requires a complicated and large-scale structure and a large installation and operation space. Moreover, preparatory processes need to be performed for both the rubber components such as the inner liner and the tread and the reinforcing members such as the carcass and the belt before they are supplied for formation. Furthermore, the system requires a wide space for storing various types of plenty of components to facilitate arrangement switching at the time of size change of the tire. Recently, such a technique has been proposed which builds rubber components having predetermined cross sections by overlapping and spirally winding unvulcanized rubber strips formed by extrusion into ribbon shapes on a building drum (see Patent Reference Nos. 1 through 4 shown below, for example). According to the technique which builds the rubber components constituting the tire by winding the rubber strips discussed above, the rubber volume considerably differs depending on the types of rubber components. For example, the rubber volume of the components such as the tread and the side walls is relatively large, and the rubber volume of the components such as the under-belt pads and the chafers is relatively small. The rubber components having large rubber volume requires longer time for winding. In formation of the tire, therefore, the arrangement of the building positions of the respective rubber components is an important factor associated with time required for winding of the respective rubber components. When the building time is not equalized for each of the primary and secondary building steps, loss time is produced in the building cycle. According to the method disclosed in the Patent Reference No. 1, for example, a breaker corresponding to the belt and the tread are sequentially laminated at a position for building the final shape in the secondary building step. Thus, the side walls are built by winding rubber strips at a position for building the green case in the primary building step. However, since the under-belt pads are also built by winding rubber strips at the position for building the green case, the building cycle in the primary building step takes longer time as the rubber volume of the side walls increases. In this case, there is a possibility that prolongation of the entire building cycle time occurs. Patent Reference No. 1: JP-B-6-51367 Patent Reference No. 2: JP-A-9-29858 Patent Reference No. 3: JP-A-2002-178415 Patent Reference No. 4: JP-A-2002-205512

Characterization of clinical strains of Aspergillus terreus complex: molecular identification and antifungal susceptibility to azoles and amphotericin B. We used molecular techniques to analyse 87 (n = 70 patients) Aspergillus terreus complex isolates, all of which were identified as A. terreus sensu stricto. The antifungal susceptibilities determined with CLSI M38-A2 (and Etest for amphotericin B) and expressed as mg/L for range of MIC/MIC(90) /geometric mean were as follows: itraconazole, 0.25-2/2/1.097; voriconazole, 0.125-2/2/1.176; posaconazole, 0.25-1/1/0.836; amphotericin B CLSI, 4-32/16/9.689; and Etest, 0.75-64/6/3.106. The MICs for amphotericin B were significantly higher than those found for the triazoles.

Mark Sutherland - Recruitment Agency Company Profile S2Consult Ltd At S2Consult we are passionate about long term successes for both candidate and client, not the short term fix. With the full understanding that it is the people that create the best business, it is our service at S2Consult Ltd to source these candidates on behalf of our clients. Contact Details Telephone 01923 67660 Mobile 07796016245 Email Social Media BNI Chipping BNI Chipping is the UK's top BNI Chapter out of over 700 chapters. How did we achieve this? By actively seeking and referring solid, profitable business to each other every week. We’ve been established as a BNI Chapter since 1998 and in the last six years alone we've passed over £25 million of business between our members. This is because we don’t just belong to BNI Chipping to make our own businesses successful, we're also there to refer business to each other. Being a member is like having a sales team of over sixty people finding you new business each week. If you want to experience a meeting for yourself you’ll find we always welcome visitors. Just click on the 'Come and Visit Us' section for more details.

Magnetic resonance imaging of uterine version in a multiethnic, nulliparous, healthy female population. To determine measurement and topography of uterine position in asymptomatic women with different ethnicity. The angle and direction of uterine version were measured using magnetic resonance imaging in nulliparous, young volunteers from 5 ethnic groups (Emiratis, other Arabs, Indians/Pakistanis, Filipinos and Europeans/ Caucasians; N=55) and compared using Europeans/Caucasians as the reference group. The uterus was anteverted on the vagina in 46 (83.6%) and retroverted in 9 (16.4%) women, with no significant difference between Europeans/Caucasians and non-Caucasians. The angle of uterine version was significantly less (i.e., the cervix was more anteverted or retroverted on the vagina) in Europeans/Caucasians as compared to other women (p=0.002), particularly Indians/Pakistanis (p < 0.00001). The degree of uterine version is different in healthy, nulliparous European/Caucasian and non-Caucasian women.

Fractures in proximal spinal muscular atrophy. Fractures are a common problem for patients with spinal muscular atrophy (SMA). A total of 131 patients with proximal SMA with an average age of 13.2 +/- 9.2 years (0.7-65.6) were evaluated retrospectively. In 60 patients 94 different fractures were observed. The group consisted of 11 patients with type Ib, 81 with type II, 33 with type IIIa, 4 with IIIb and 2 with type IV. 38 of 81 SMA II patients and 17 of 33 SMA IIIa patients had suffered fractures at an average age of 8.3 +/- 5.3 years (0.0-25.1) (SMA II) and 9.3 +/- 6.0 years (0.0-22.1) (SMA IIIa). The most frequent fractures were of the femur (50), usually distal, of the lower leg and ankle (15), and upper arm (9). The distribution of fractures was different in SMA II and SMA IIIa. Most of the fractures could be treated conservatively. Only two femoral shaft fractures, one upper arm and a lower arm fracture were treated surgically by osteosynthesis. Competent fracture treatment is an important part of the orthopaedic care of SMA patients.

+ 63. Suppose -k + 1 = 3. Which is the second smallest value? (a) f (b) k (c) w c Let p = -1.18 + 1.08. Let j = -69.3 + 61. Let n = j + 8. What is the second smallest value in p, n, -1/5? -1/5 Let n = 0 - -0.4. Let u(s) = s**3 - 8*s**2 + 5*s + 10. Let w be u(7). Let z = w + 10/3. Which is the biggest value? (a) z (b) -0.1 (c) n c Let a = -0.19 - 4.81. Let j = -0.05 - 2.95. What is the third biggest value in j, 2, a? a Let n be 1198/(-920) + 0/4. Let p = 6/115 + n. What is the second biggest value in p, -0.2, -1? -1 Suppose 3*t = 3*o + 9, -5*t + 2 = 3*o - 13. Let v = 4 - 17/4. What is the second smallest value in o, -1/3, v? v Let q = -2 - 2. Let k = q + 4.5. What is the smallest value in k, -5, 2? -5 Let o = 15 - 14.89. Let v = 3.89 + o. Which is the second biggest value? (a) v (b) -2 (c) -2/5 c Let t = 1343/3306 + -1/87. Let f = t - -2/19. Which is the third biggest value? (a) 2 (b) 0 (c) f b Let k = 25/2 - 12. Which is the third smallest value? (a) k (b) -5 (c) 0.1 a Let m = -0.4 - -0.3. Let y be (-2)/9 + (-1806)/135. Let s = -738/55 - y. What is the third biggest value in m, s, 5? m Let l = -19 - -22. What is the biggest value in 1/2, l, 3/7? l Suppose -3*i = -0*i - 3. Let b = 0.03 - 0.33. What is the second smallest value in b, 4, i? i Let k = 5.05 + -0.05. Which is the second biggest value? (a) k (b) 0.2 (c) 0.1 b Let v = 3/61 + 107/305. Suppose 3*i = -2*i - 10. What is the biggest value in i, v, -1? v Let s = -91 + 91.5. Which is the second smallest value? (a) 3 (b) s (c) 2 c Let y be (0 - 48/63)*15/20. What is the biggest value in 0.4, y, -2, 1/8? 0.4 Let q = 12 + -17. Which is the second smallest value? (a) 6 (b) 5 (c) q b Suppose -5*n + 0*n = 0. Suppose n = 3*x + 4 + 5. Let q = 0.42 + 0.08. Which is the biggest value? (a) x (b) 0.2 (c) q c Let l = -11 + 8. Let i be (-1*(-1 + 2))/(-1). Let z be (-30)/(-21) - (i - 0). What is the third smallest value in l, z, 0.3? z Suppose 7 = 5*z - 4*z. Suppose -2*s = 3 - z. Let g be (-1)/(-2)*s/4. What is the third biggest value in g, 2, -1/5? -1/5 Let p(g) = -14*g**3 + g**2 - 1. Let v be p(-1). Let j = v - 9. What is the smallest value in 0.5, -0.5, j? -0.5 Let g(t) = 4*t + 28. Let r be g(-8). Which is the smallest value? (a) -5 (b) -2/5 (c) r a Let j = -0.06 + -5.94. Let r = 9 + j. Let x be (2/(-4))/((-1)/2). Which is the smallest value? (a) r (b) x (c) -0.3 c Let u(d) = 2*d - 2. Let m be u(2). Suppose m*f + 10 = 7*f. Suppose -2*c = f*c - 4. What is the smallest value in -1, c, -0.4? -1 Suppose j = -h - 2*j + 10, 2 = 2*h - 3*j. Let z be 1/3 - h/(-6). Let o be 8/22 - (-57)/418. What is the third biggest value in -1, z, o? -1 Let f = 2.42 + -2.2. Let w = 0.08 + f. Suppose 5*x + 0*x - 13 = 2*c, 3*c = 5*x - 12. What is the second smallest value in c, 0, w? w Let q = 45 + -47. Which is the smallest value? (a) 4 (b) q (c) 0.1 b Let h = 1 + -4. Let z = -14/75 - 12/25. Which is the third biggest value? (a) h (b) 2 (c) z a Let q = 0.3 - -1.7. Let z = -46 + 45.9. Let u = -0.04 + -0.36. Which is the third biggest value? (a) z (b) q (c) u c Let i(q) = -q + 15. Let o be i(12). Suppose -o*u + 1 - 3 = -p, 4*p + 5*u = -26. Which is the third smallest value? (a) -3 (b) 0 (c) p b Let i = -1063/15 + 71. Let y = 0.9 + 0.1. Let m = 1 - y. What is the third biggest value in i, 1/2, m? m Let m = 1.57 - 1.5. Which is the second biggest value? (a) -3/5 (b) m (c) -3 a Let g = -7 - -6.9. Let o = 0.1 + g. Which is the third smallest value? (a) o (b) 5 (c) -0.2 b Let x = 47 - 51. Let o = 8 + -6. Let g be o - (-1)/((-27)/60). What is the second smallest value in g, x, -5? x Let k = -20 + 30. Let h = -1 + 12. Let g = k - h. What is the biggest value in g, -4, 2? 2 Let k = 5 + -1. Let z(j) = j**3 - 4*j**2 - j + 2. Let p be z(k). What is the biggest value in -4, -0.4, p? -0.4 Let v(i) = -i - 1. Let t be v(1). Let z(o) = -o**2 - 2*o. Let k be z(t). Let s = 7 + -15/2. Which is the second smallest value? (a) -1 (b) s (c) k b Let j be (8/(-14))/((-6)/21). Which is the third biggest value? (a) j (b) 1/4 (c) 0.5 b Suppose -5*j + 8 + 2 = 0. Let r = -0.4 + 4.4. Let h = 2 + -2.2. Which is the biggest value? (a) j (b) h (c) r c Let w = -361/7 + 58. Let s = -6 + w. Let l = 7.1 + -7. Which is the third biggest value? (a) l (b) 0.2 (c) s a Let r = -3.82 + -0.18. What is the second smallest value in -0.4, -18, -2/7, r? r Let f be 105/(-126)*(-4)/(-15). What is the third biggest value in 0.3, f, -3/7? -3/7 Let p = 0.02 - 0.52. Let u = -0.7 - p. Which is the third smallest value? (a) -1/4 (b) -5 (c) u c Let l = -23 + 22. Which is the smallest value? (a) -5 (b) 2/7 (c) l a Let s = -4.6 + 4.4. Which is the second biggest value? (a) 4 (b) s (c) -2 b Let b = 0.32 - 21.32. Let m = b - -20.8. What is the second smallest value in m, 0.1, -2/3? m Let w be (2 - (-18)/(-10))*1. Which is the second smallest value? (a) -1 (b) -2 (c) w a Let a be (-1 - -7)*2/3. Let d be -2 + a/(-6)*-3. Suppose 4*g + d - 4 = 0. What is the biggest value in g, 5, -1? 5 Let h(i) = 2*i - 2. Let r be h(4). Suppose -5*s = -m + 19, m = 4*s + r*m - 8. Which is the third biggest value? (a) 2 (b) s (c) 0 b Let s = 25/3 + -197/24. Let w = 4 - 6. Which is the second smallest value? (a) s (b) 0.5 (c) w a Let w = -1.2 + 1. Let t = 3.8 - w. What is the smallest value in 2, t, 0.1? 0.1 Let y be (-12)/(-90) - 17/15. Which is the smallest value? (a) y (b) 0.2 (c) 0.1 a Let z = -0.16 - -0.66. Which is the second biggest value? (a) 0.1 (b) -4/7 (c) z a Suppose 2*s = -o + 9, 6*s = -2*o + s + 23. Let d be 1/(-4) + o/8. Which is the second smallest value? (a) 3/2 (b) d (c) -0.2 c Let k = -2.06 + 0.06. Let j = -5 - k. What is the biggest value in 0.2, -0.3, j? 0.2 Let r be 0 + ((-1)/1)/(-2). Let n = 0.7 - 0.7. Let g = n + 4. Which is the third biggest value? (a) r (b) 2 (c) g a Let z = -3.8 - 1.2. Let y = 1.1 + -0.7. Which is the biggest value? (a) 3 (b) y (c) z a Let k = -13/6 + 29/12. Which is the smallest value? (a) 4 (b) k (c) 5 b Let i = -164 + 163.6. Let d = 1 - 2. Which is the third smallest value? (a) -2/3 (b) d (c) i c Let p = 62 + -187/3. What is the third biggest value in -2, -0.2, p, 3/4? p Let o = -0.3 - -2.3. Let n = 3 - 5. Let m = -4.99 - 0.01. What is the third biggest value in m, o, n? m Let p = 0.04 + -3.04. What is the second smallest value in p, -1, 4? -1 Let p = 10.3 + 0.7. Let i = 11.3 - p. Which is the smallest value? (a) i (b) -0.5 (c) 0.1 b Suppose -4*u + 24 = 3*v + v, 2*v = -u + 10. Which is the second biggest value? (a) -1/8 (b) 5/2 (c) u c Let j be 1615861/44520 - 3/(-6). Let r = j + -1968/53. Let w = r + -4/105. Which is the second smallest value? (a) -1 (b) w (c) -3 a Let h = -1227 - -2399/2. Let l = h - -28. Let k = -0.14 + 4.14. What is the third smallest value in k, -0.4, l? k Let k = 18 - 20. Which is the smallest value? (a) -3 (b) -0.3 (c) 2/3 (d) k a Let t = 57/424 + -1/106. Which is the second biggest value? (a) -2/13 (b) 4/5 (c) t (d) 4 b Let z = -33 + 51. Let o be (-3)/6*z/15. Let t = -0.2 + 0.2. What is the third smallest value in o, 0.1, t? 0.1 Let y = -4 - 4. Let u = y + 11. Let f = 0.1 - 0. What is the biggest value in 5, f, u? 5 Suppose 5*l + 27 = -2*y, -5*y + 2*y - 51 = 4*l. Let t be 1*27/y + 1. Let b = -191 - -1333/7. What is the second biggest value in b, 2/5, t? t Let q = 0.23 + -0.43. Which is the fourth biggest value? (a) q (b) 2/3 (c) -1 (d) 2/7 c Let y = 0.17 + 1.83. Which is the biggest value? (a) -2/3 (b) -0.2 (c) y c Let k(t) = 1 + 60*t + 1 + 6*t. Let r be k(3). Let n = r - 2202/11. Which is the smallest value? (a) n (b) 2 (c) 0.5 a Let j = 0.24 + 0.06. Let r = j - 0.1. Let o = r + 0. Which is the third smallest value? (a) 0.3 (b) -0.1 (c) o a Let y = -0.1 - -0.3. Which is the third biggest value? (a) 2 (b) 0.4 (c) y c Let l = -103 + 147. Let m = 133/3 - l. Let y = -10 - -9. Which is the smallest value? (a) 4/5 (b) y (c) m b Let d(i) = 4 + 0*i + 1 - i. Let l be d(6). Let n be (-1 + 5/2)/(21/4). Which is the smallest value? (a) l (b) n (c) -4 c Let z = 27 + -24. What is the second smallest value in -2, z, 1/7? 1/7 Let r = 2 + -2.5. Let u = -1.4 + 1. Let z = -18 + 122/7. What is the second smallest valu

insuranceQuotes in the news Get My Best Advice Laura Adams is an award-winning personal finance expert, consumer advocate and author of Money Girl’s Smart Moves to Grow Rich. As insuranceQuotes spokesperson, she has been featured on USA Today, FOX News, CBS News, NBC News, ABC Radio, NPR, The New York Times and thousands of other media outlets. Is it the right time to shop for Auto Insurance? Did you know that car insurance rates constantly fluctuate and vary each month? Find out when you should shop for new quotes. See how my rates are trending: Average Insurance Rates 6 Month Trend How we calculate these rates How we calculate these rates:X In addition to your input, rates are based on one car and one driver with no traffic violations and state minimum coverage. Rates assume the driver is an employed college graduate and a homeowner with no lapse in coverage. Vehicle is assumed to be garaged on premises and used primarily for commuting and is driven 15,000 miles annually. These rates also include a percentage discount to reflect an aggregate of commonly available carrier discounts. Rates displayed are estimates and are not guaranteed. State: Vehicle Type: Gender: Age: Marital Status: Rates are moving up! Lock in rates before they rise. $101a month Drivers like you are paying an average of $101/mo right now. How we calculate these rates: How we calculate these rates:X In addition to your input, rates are based on one car and one driver with no traffic violations and state minimum coverage. Rates assume the driver is an employed college graduate and a homeowner with no lapse in coverage. Vehicle is assumed to be garaged on premises and used primarily for commuting and is driven 15,000 miles annually. These rates also include a percentage discount to reflect an aggregate of commonly available carrier discounts. Rates displayed are estimates and are not guaranteed. Rates are on the rise for drivers like you! If you are currently paying more than $101/mo, now may be the perfect time for you to lock in low rates before they rise again. Give our free customized quote comparison tool a test drive to see just how much your rates can be reduced!

package org.basex.query.func.validate; import org.basex.query.*; import org.basex.query.func.*; import org.basex.query.value.item.*; import org.basex.util.*; /** * Function implementation. * * @author BaseX Team 2005-20, BSD License * @author Christian Gruen */ public final class ValidateXsdProcessor extends StandardFunc { @Override public Item item(final QueryContext qc, final InputInfo ii) { return Str.get(ValidateXsd.IMPL[ValidateXsd.OFFSET + 1]); } }

<html> <head> <title>Path test</title> <style type="text/css"> .pixel { position: absolute; width: 1px; height: 1px; overflow: hidden; background: #000; } .red { background: red; } .blue { background: blue; } </style> <script language="JavaScript" type="text/javascript"> // Dojo configuration djConfig = { isDebug: true }; </script> <script language="JavaScript" type="text/javascript" src="../../dojo.js"></script> <script language="JavaScript" type="text/javascript"> dojo.require("dojo.math.*"); function drawCurve(curve,steps,className) { if(!className) className = "pixel"; if(!steps) steps = 100; this.pixels = new Array(steps) for(var i=0;i<steps;i++) { var pt = curve.getValue(i/steps); this.pixels[i] = document.createElement("div"); this.pixels[i].className = className; this.pixels[i].style.left = pt[0]; this.pixels[i].style.top = pt[1]; document.body.appendChild(this.pixels[i]); } } function init(){ var c = dojo.math.curves; var p = new c.Path(); p.add(new c.Line([10,10], [100,100]), 5); p.add(new c.Line([0,0], [20,0]), 2); p.add(new c.CatmullRom([[0,0], [400,400], [200,200], [500,50]]), 50); p.add(new c.Arc([0,0], [100,100]), 20); p.add(new c.Arc([0,0], [100,100], true), 20); drawCurve(p, 200, "pixel"); //drawCurve(new c.Line([0,250], [800,250]), 50, "pixel red"); //drawCurve(new c.Line([500,0], [500,600]), 50, "pixel red"); //drawCurve(new c.Arc([300,300], [700,200]), 50, "pixel"); //drawCurve(new c.Arc([200,200], [100,100], false), 50, "pixel blue"); } dojo.addOnLoad(init); </script> </head> <body> </body> </html>

Avalancha de Éxitos Avalancha de Éxitos (Avalanche of Hits) was Café Tacuba's third album. In 1996, two years after their acclaimed Re, the band had amassed enough new music to fill four CDs, but couldn't winnow it down to a single album. So instead, they covered eight songs by other Spanish-speaking artists, who ranged from totally obscure to well-known. Track listing All the covers are very different from the originals - and from each other. Chilanga Banda is a hip-hop piece in Mexican slang (featuring the sound "ch"), and Ojalá Que Llueva Café is marked by fast-paced fiddle and rapid switching from chest register to head register - reminiscent, in fact, of yodeling. This is a continuation of the precedent the band established with Re, their previous album, of constant genre-shifting. Band members Anónimo (Rubén Albarrán): vocals, guitar Emmanuel del Real: keyboards, acoustic guitar, piano, programming, vocals, melodion Joselo Rangel: electric guitar, acoustic guitar, vocals Quique Rangel: bass guitar, electric upright bass, vocals References Category:Café Tacuba albums Category:1996 albums

Burry Port railway station Burry Port railway station served the town of Burry Port (). It continued to serve the inhabitants of the area near Llanelli between 1909 and 1953 and was one of several basic halts opened on the Burry Port and Gwendraeth Valley Railway in Carmarthenshire, Wales (). History The station was opened as Burry Port in 1898 but regular passenger services began on 02 August 1909 by the Burry Port and Gwendraeth Valley Railway on the Kidwelly and Burry Port section of the line and was closed by the British Transport Commission in 1953 with the last passenger train running on Saturday 19 September 1953. It was on the southern section of the Burry Port and Gwendraeth Valley Railway with Pembrey to the north and Burry Port as the termuinus of the passenger line. The line had been built on the course of an old canal with resulting tight curves, low bridge clearance and a tendency to flooding. The freight service continued for coal traffic on the Cwmmawr branch to Kidwelly until 1996 by which time the last of the local collieries had closed down and the washery closure followed. Pembrey amd Burry Port on the West wales line lies to the east. Infrastructure The station had a single short platform, a brick built toilet block and a substantial corrugated iron ticket office and waiting room with a canopy on the northern side of the single line. The station had a run round passing loop and two carriage sidings, one of which also served a goods shed. Signalling was present. The Kidwelly route was used for coal trains, resulting in the lifting of track between Trimsaran Road and Burry Port by 2005. Burry Port railway station on the West Wales line stood close to the site of the old Burry Port and Gwendraeth Valley Railway. Services The station was open for use by the general public by 1909. Remnants The section of the old line between Burry Port and Craiglon Bridge Halt is now a footpath and the NCN 4 cyclepath. The station site is now part of a roundabout. Routes See also West Wales lines References Category:Disused railway stations in Carmarthenshire Category:Railway stations opened in 1898 Category:Railway stations opened in 1909 Category:Railway stations closed in 1953

Sulfadoxine-pyrimethamine resistance in Plasmodium falciparum: a zoomed image at the molecular level within a geographic context. Antimalarial chemotherapy is one of the main pillars in the prevention and control of malaria. Following widespread resistance of Plasmodium falciparum to chloroquine, sulfadoxine-pyrimethamine came to the scene as an alternative to the cheap and well-tolerated chloroquine. However, widespread resistance to sulfadoxine-pyrimethamine has been documented. In vivo efficacy tests are the gold standard for assessing drug resistance and treatment failure. However, they have many disadvantages, such as influence of host immunity and drug pharmacokinetics. In vitro tests of antimalarial drug efficacy also have many technical difficulties. Molecular markers of resistance have emerged as epidemiologic tools to investigate antimalarial drug resistance even before becoming clinically evident. Mutations in P. falciparum dihydrofolate reductase and dihydrofolate synthase have been extensively studied as molecular markers for resistance to pyrimethamine and sulfadoxine, respectively. This review highlights the resistance of P. falciparum at the molecular level presenting both supporting and opposing studies on the utility of molecular markers.

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---------------------- Forwarded by Laura Vuittonet/Corp/Enron on 02/28/2001 12:26 PM --------------------------- From: Julie Pechersky/ENRON@enronXgate on 02/28/2001 11:07 AM To: Laura Vuittonet/Corp/Enron@Enron cc: Sonya Johnson/ENRON@enronXgate Subject: FW: Report for Tom Martin - Tx Desk Let me know if you have any questions, or see any changes that need to be made. Thanks, Julie Nothing under 0413/105633 Nothing under 0413/105984 -----Original Message----- From: Vuittonet, Laura Sent: Wednesday, February 28, 2001 10:12 AM To: Julie Pechersky/HOU/ECT@ENRON Subject: Report for Tom Martin - Tx Desk Hi, Julie. I really appreciate you getting this information for me. The company/cost centers that I need the information for are as follows: 0012/106012 0012/105978 0413/105633 0012/105982 0413/105984 0012/105977 The reason we need this information is because there are some people who are Houston Pipe Line employees, and we want to ensure that they have or do not have the applications they are required or not required to have. Tom Martin is over the Texas Desk, and he is the person who would like this information. Thanks again! Laura Vuittonet x31994

The environment minister, Emmanuel Niyonkuru has been killed by an unknown gunman in the conflict-ridden East African Nation of Burundi, ... The environment minister, Emmanuel Niyonkuru has been killed by an unknown gunman in the conflict-ridden East African Nation of Burundi, as said by a police spokesman on Sunday. According to police spokesman, Pierre Nkurikiye, who said on twitter that the minister was shot dead with a pistol in the early hours of Sunday along the streets of the Rohero neighbourhood in the capital, Bujumbura. Police also arrested a woman over her alleged involvement in the assassination, the spokesman added. However, Burundi has been suffering from ongoing political violence since president Pierre Nkuruziza won a third term in office in July 2105 elections, even despite the constitutional two-term limit.

The effects of turbulent jet flows on plant cell suspension cultures Cell suspensions of Morinda citrifolia were subjected to turbulent flow conditions in a submerged jet apparatus, to investigate their hydrodynamic shear susceptibility. The suspensions were exposed to repeated, pressure-driven passages through a submerged jet. Two nozzles, of 1 mm and 2 mm diameter, were employed. Average energy dissipation rates were in the range 10(3)-10(5) W/kg and cumulative energy dissipation in the range 10(5)-10(7) J/m3. System response to the imposed conditions was evaluated in terms of suspension viability (determined using a dye exclusion technique) and variations in both chain length distribution and maximum chain length. Viability loss was well-described by a first-order model, and a linear relationship was identified between the specific death rate constant and the average energy dissipation rate. This relationship was consistent with results obtained using the same suspension cultures in a turbulent capillary flow device. Morphological measurements indicated that exposure to the hydrodynamic environment generated in the jet resulted in a significant reduction in both the average and maximum chain lengths, and the reduction in the maximum chain length was identified as an appropriate measure of sustained damage. Analysis of both viability and chain length in terms of cumulative energy dissipated revealed good agreement with results reported by other authors for morphologically different plant cell systems. Copyright 1998 John Wiley & Sons, Inc.

1. Introduction {#sec0005} =============== Cytokines are a broad and loose group of small cell-signaling proteins that play important roles in cell growth, proliferation, differentiation, apoptosis, angiogenesis, immunity and inflammatory response. They include interferons (IFN), interleukins (IL), chemokines, lymphokines, and tumor necrosis factors (TNF). They are produced by a variety of cells, including macrophages, B and T lymphocytes, mast cells, endothelial cells, epithelial cells, fibroblasts, and various stromal cells. Cytokines that are produced at the site of infection stimulate and coordinate innate and adaptive immune responses against invading pathogens ([@bib0135], [@bib0185], [@bib0365]). They act through their matching receptors on the surface of target cells, followed by cascades of intracellular signaling. One such frequently activated intracellular signaling is the JAK-STAT pathway, which is indispensable and pivotal in many biological processes including immunity and inflammatory response ([@bib0275], [@bib0340]). Dysregulation of JAK-STAT signaling results in immunodeficiency and immune-mediated disorders ([@bib0270], [@bib0275]). Mutations in the components of JAK-STAT pathway cause immunodeficient and autoimmune disorders ([@bib0050], [@bib0190]). Due to the importance of JAK-STAT signaling in the host immune response, it is often targeted by pathogens, including PRRSV ([@bib0290], [@bib0400], [@bib0405]). PRRSV causes a contagious disease that is characterized by reproductive failure in sows and respiratory disease of variable severity in pigs of all ages ([@bib0235]). PRRS has caused substantial economic losses to the swine industry and remains one of the most economically important diseases in pigs since it was first reported in 1987 ([@bib0165], [@bib0265]). A typical feature of the immune response to PRRSV infection in pigs is delayed production and low titer of virus neutralizing antibodies, and weak cell-mediated immune response ([@bib0210], [@bib0235], [@bib0435]). PRRSV infection is also characterized by prolonged viremia followed by the persistent presence in regional lymph nodes for as long as 250 days ([@bib0425]). One of the possible reasons for the weak protective immune response is that PRRSV interferes with innate immunity, including type I interferons (IFNs), and cytokine-mediated JAK-STAT signaling ([@bib0010], [@bib0045], [@bib0290], [@bib0350], [@bib0405], [@bib0395]). 1.1. JAKs and STATs {#sec0010} ------------------- In mammals, there are four JAKs: JAK1, JAK2, JAK3, and Tyk2, ranging in size from 120 to 140 kDa ([@bib0140]). JAK1, JAK2, and Tyk2 are ubiquitously expressed, whereas JAK3 expression is restricted to cells of the hematopoietic system. The JAK protein is pre-associated with cytokine receptors in the cytoplasmic side and is an important determinant of their levels and signaling potential ([@bib0140]). Upon cytokine binding, the receptor chains are brought into close proximity, leading to the juxtaposition of two JAK kinase domains and consequent trans-phosphorylation. Once activated, JAKs phosphorylate STAT proteins via Src homology 2 (SH2) domain interaction ([@bib0155]). Even though responding to different cytokines, JAKs selected by different receptors activate specific STAT members for defined functions ([@bib0140]). There are seven mammalian STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6, which range from 750 to 950 amino acids in polypeptide length and feature several conserved domains ([@bib0330], [@bib0340]). STATs are latent transcription factors located in the cytoplasm until activated. Each STAT member responds to a defined set of cytokines ([@bib0205], [@bib0270], [@bib0275]). The seven STATs go through similar activation processes and exhibit global conservation in function ([@bib0340]). In brief, ligand-mediated receptor multimerization leads to trans-phosphorylation of JAKs, which then create docking sites in the receptor for STATs and phosphorylate them. Phosphorylated STATs form homodimer or heterodimer complexes, followed by translocation into the nucleus by importins and binding to response element in DNA to activate or repress transcription of a defined set of genes ([@bib0340]). 1.2. STAT signaling and functions {#sec0015} --------------------------------- Among the seven STATs, STAT1 and STAT2 mainly mediate the IFN-activated signaling ([@bib0270]). STAT1 is involved in signaling by type I, type II, and type III IFNs. In response to type I IFNs (IFN-α or IFN-β), STAT1 and STAT2 are phosphorylated, followed by heterodimer formation and then interaction with interferon regulatory factor 9 (IRF9) to form a heterotrimer known as interferon-stimulated gene factor 3 (ISGF3) ([@bib0090]) ([Fig. 1](#fig0005){ref-type="fig"} A). The ISGF3 is translocated into nucleus and binds to interferon-stimulated response element (ISRE) in DNA to activate the expression of interferon-stimulated genes (ISGs). Upon IFN-γ stimulation, activated STAT1 forms homodimers, followed by nuclear translocation and activation of gene expression via binding to interferon-gamma-activated-sequence (GAS) in DNA ([@bib0270]). Type III IFNs also activate STAT1 and STAT2 for ISRE transactivation like type I IFNs ([@bib0470]).Fig. 1PRRSV interference with type I IFN-activated JAK-STAT signaling. A. Canonical signaling. IFN-α/β binds to their receptors IFNAR-1 and IFNAR-2 on the cell membrane and activates the JAK-STAT1/STAT2 pathway. The phosphorylated STAT1 and STAT2 form heterodimer, followed by interaction with IRF9 to form interferon-stimulated gene factor 3 (ISGF3). Karyopherin α1 (KPNA1), an adaptor protein binding ISGF3, is essential to mediate the nuclear import of ISGF3 via interaction with karyopherin β1 (KPNB1). The ISGF3 binds to interferon-stimulated response element (ISRE) in DNA to activate transcription of interferon-stimulated genes (ISGs). "P" besides STATs indicates phosphorylation. PRRSV nsp1β inhibits ISGF3 nuclear translocation via inducing degradation of KPNA1. PRRSV N protein also inhibits ISGF3 nuclear translocation. PRRSV nsp2 reduces ISG15 production and conjugation via its deubiquitination activity. PRRSV induces elevation of miRNA miR-30c to downregulate JAK1 and SOCS1 to inhibit JAKs. PRRSV inhibits PKR during its early infection of pulmonary alveolar macrophages. B. STAT1-independent signaling. Type I IFNs activate alternative JAK-STAT2 signaling without STAT1. The ISGF3-like complex binds to ISRE and interferon-gamma-activated sequence (GAS) to activate alternative sets of ISGs. PRRSV reduces STAT2 protein to inhibit this pathway.Fig. 1 In addition to the canonical signaling described above, IFNα signaling occurs through alternative complexes containing STAT2 and IRF9 without STAT1 ([@bib0030], [@bib0110]) ([Fig. 1](#fig0005){ref-type="fig"}B). Moreover, STAT2 can form heterodimer with other STATs, like STAT3 and STAT6, followed by binding to diverse sequences, like GAS. Further studies demonstrate the existence of a STAT1-independent IFN signaling pathway, in which STAT2/IRF9 directs a prolonged antiviral activity ([@bib0025], [@bib0035]). STAT3 is activated by many cytokines and had multiple functions including differentiation of T helper 17 (Th17) and generation of CD8^+^ T cell memory response ([@bib0055], [@bib0275], [@bib0380]). Numerous cytokines including IL-5, IL-6, IL-9, IL-10, IL-11, IL-12, IL-21, IL-22, IL-27, oncostatin M (OSM), IFN-γ, TNF-α and leukemia inhibitory factor (LIF), trigger STAT3 activation ([@bib0125], [@bib0205]). The IL-6 family of cytokines including IL-6, OSM, and LIF bind to the receptor complex containing the common glycoprotein 130 (gp130) and activate STAT3, known as gp130/JAK-STAT3 signaling ([Fig. 2](#fig0010){ref-type="fig"} ). STAT3 is needed for differentiation of follicular T helper and Th1 cells ([@bib0295]), as well as activation and maturation of dendritic cells (DCs) ([@bib0285]). Mutations in STAT3 cause autosomal dominant hyper-IgE syndrome, a rare multisystem primary immunodeficiency characterized by recurrent bacterial infections in skin and lung and with abnormally high levels of IgE ([@bib0160], [@bib0245]). STAT3 is indispensable for promoting host defense against virus infections. For instance, during Herpes simplex virus-1 (HSV-1) infection, STAT3 promotes the activation of CD8+ T cells response ([@bib0460]). It has been shown that gp130-STAT3 signaling is critical for the innate immune response against coxsackievirus B3 virus (CVB3) infection ([@bib0450]). In addition, STAT3 plays a protective role in regulating virus-induced proinflammatory response, as shown in STAT3 knock-out studies ([@bib0100], [@bib0195], [@bib0240]). Highly pathogenic avian influenza (HPAI) H5N1 virus induces strong proinflammatory response in chickens via inhibition of STAT3 phosphorylation ([@bib0200]).Fig. 2PRRSV interference with JAK-STAT3 signaling activated by IL-6 family cytokines. IL-6 binds to its receptor IL-6R and gp130, leading to JAK phosphorylation of STAT3, followed by STAT3 homodimer formation. KPNA6 is the adaptor protein to bind to STAT3 and interact with KPNB1 for the nuclear translocation. The STAT3 homodimer binds to STAT3 response element (RE) in DNA to activate transcription of target genes. PRRSV nsp5 induces STAT3 degradation to inhibit JAK-STAT3 signaling.Fig. 2 STAT4 is activated by IL-12 and is essential for Th1 cell differentiation ([@bib0325]). Even though its distribution is restrained in myeloid cells, testis and thymus, STAT4 is critical for the host immunity. It is also activated by IL-23 to induce expansion of Th17 cells and the associated autoimmunity ([@bib0325]). Moreover, STAT4 is crucial for the biological effects of macrophage, natural killer cell, mast cell, and dendritic cell as well as IFN-γ production ([@bib0225]). STAT5 is activated by IL-2, IL-3, IL-5 and granulocyte macrophage colony-stimulating factor (GM-CSF), and is essential for regulatory T cell (Treg) differentiation ([@bib0270]). STAT5 can also be activated by IL-7 and IL-15, contributing to the generation of CD8^+^ memory cells and B lymphopoiesis ([@bib0270], [@bib0275]). STAT5A and STAT5 B are two highly related proteins and have indispensable roles, especially to the effector and Treg response, for which STAT5 B is dominant ([@bib0385]). Tregs takes charge of maintaining homeostasis and controlling the immune response by restraining immunocompetent effector cells ([@bib0020]). STAT6 is activated by IL-4 and IL-13 and is pivotal for Th2 and Th9 lymphocyte differentiation ([@bib0275], [@bib0390]) ([Fig. 3](#fig0015){ref-type="fig"} A). STAT6 has been demonstrated to regulate lung inflammatory responses in animal models ([@bib0390]). Moreover, STAT6 contributes to alternative activation of macrophages and lung anti-viral responses in a JAK-independent manner ([@bib0065]). Viral or cytoplasmic nucleic acids trigger STING (stimulator of interferon genes) or MAVS (mitochondrial antiviral-signaling protein) to recruit STAT6 to the endoplasmic reticulum, followed by TBK1 (TANK-binding kinase 1) phosphorylation of STAT6 and nuclear translocation ([Fig. 3](#fig0015){ref-type="fig"}B). Expression of chemokines, including CCL2, CCL20, and CCL26, are then activated to recruit immune cells to combat viral infection ([@bib0065]).Fig. 3PRRSV interferes with STAT6 signaling. A. Canonical JAK-STAT6 signaling. IL-4 and IL-13 bind to receptors, leading to JAK phosphorylation of STAT6, followed by homodimer formation and nuclear translocation to activate target genes. PRRSV reduces STAT6 protein level to inhibit the signaling. B. JAK-independent STAT6 signaling. Viral nucleic acids (dsRNA or dsDNA) activate MAVS and STING on mitochondria and endoplasmic reticulum (ER), respectively, leading to TBK1 (TANK-binding kinase 1) phosphorylation of STAT6, followed by homodimer formation and nuclear translocation to activate alternative target genes, including antiviral chemokines. PRRSV reduces STAT6 protein level to inhibit the signaling.Fig. 3 1.3. PRRSV {#sec0020} ---------- PRRSV is a small, enveloped RNA virus of the genus *Arterivirus*, family *Arteriviridae*, order *Nidovirales* ([@bib0105]). There are two PRRSV genotypes: Type 1 (European PRRSV) and Type 2 (North American PRRSV), which have around 60% genomic nucleotide identity ([@bib0105]). In a new proposal to the International Committee on Taxonomy of Viruses (ICTV), PRRSV Type 1 and Type 2 viruses are classified as two separate species: *Porcine reproductive and respiratory syndrome virus 1* and *Porcine reproductive and respiratory syndrome virus 2,* respectively, due to their big genomic difference ([@bib0040]). PRRSV genome is a linear, non-segmented, single-stranded, and positive-sense RNA in a size of approximately 15 kb ([@bib0075], [@bib0105]). Over ten open reading frames (ORFs) have been identified in the PRRSV genome. About four-fifths of the genome encode polyproteins that are cleaved into 14 non-structural proteins (nsps) and the 3′-terminal one-fifth encodes eight structural proteins ([@bib0235]). The main target cells for PRRSV infection *in vivo* are some monocyte/macrophage lineages, mainly pulmonary alveolar macrophages (PAMs) ([@bib0235], [@bib0320], [@bib0420]). PAMs are important effector immune cells of the innate immune system against pathogens in the lung ([@bib0115]). Cytokines like IFN-γ and GM-CSF activate JAK-STAT signaling to regulate macrophage phenotype and activation ([@bib0170]). Activated macrophages secrete immune regulatory cytokines including IL-1β, IL-6, IL-12, TNF-α, and so on ([@bib0115]). 2. PRRSV interference with JAK-STAT signaling {#sec0025} ============================================= To evade the host antiviral response, viruses have evolved numerous strategies including dysregulating JAK-STAT pathway. For example, Epstein-Barr virus (EBV) suppresses IFN signaling by inhibiting the expression of the IFN-γ receptor ([@bib0255]). Paramyxovirus V protein induces STAT protein degradation to evade IFN response ([@bib0280]). Ebola virus VP24 blocks pSTAT1 (phosphorylated STAT1) nuclear translocation by binding KPNA1 ([@bib0300], [@bib0305]). The ORF6 product of severe acute respiratory syndrome coronavirus disrupts nuclear import of pSTAT1 by tethering KPNA2 to the endoplasmic reticulum/Golgi membrane ([@bib0120]). Highly pathogenic avian influenza (HPAI) H5N1 virus inducing a strong proinflammatory response in chickens by inhibiting STAT3 phosphorylation ([@bib0200]). PRRSV is known to inhibit IFN-activated JAK-STAT signaling by blocking the ISGF3 nuclear translocation ([@bib0290], [@bib0405]). 2.1. PRRSV inhibits IFN-mediated JAK-STAT signaling {#sec0030} --------------------------------------------------- PRRSV inhibits the IFN-activated JAK-STAT signal transduction and ISG expression in both MARC-l45 and PAM cells ([@bib0290], [@bib0400], [@bib0405]). PRRSV proliferation in MARC-145 cells suppresses JAK-STAT signaling stimulated by IFN-α. The transcripts of ISG15 and ISG56 and protein level of STAT2 in PRRSV-infected cells were much lower than mock-infected cells upon IFN stimulation. PRRSV blocks the nuclear translocation of the IFN-induced ISGF3 complex via nsp1β ([@bib0060], [@bib0290]). Avirulent Ingelvac^®^ PRRS MLV has no effect on the IFN-activated JAK-STAT signaling in PAMs ([@bib0290]). Further studies demonstrate that nsp1β inhibits the JAK-STAT signaling via inducing the degradation of KPNA1, which is a critical adaptor protein to mediate the nuclear import of ISGF3 ([@bib0405]) ([Fig. 1](#fig0005){ref-type="fig"}A). Infection of MARC-145 cells by moderate virulent PRRSV strains VR-2332 and VR-2385 also result in KPNA1 reduction, whereas the Ingelvac^®^ PRRS MLV does not. Nsp1β of VR-2385 induces elevation of KPNA1 ubiquitination and shortening of its half-life. Analysis of nsp1β deletion constructs identifies its N-terminal domain to be involved in the ubiquitin-proteasomal degradation of KPNA1 ([@bib0405]). Sequence analysis of nsp1β from VR-2332 and MLV indicates there are only two different nucleotides, leading to two variable amino acids at residue 19 and 151. Substitution of the N-terminal nucleotide resulting in alteration of residue 19 from valine to isoleucine abolishes the ability of VR-2385 nsp1β to induce KPNA1 degradation and to inhibit IFN-mediated signaling. In contrast, MLV nsp1β has no effect on KPNA1, however, a mutant MLV nsp1β with residue 19 alternation from isoleucine to valine gains the ability to induce KPNA1 degradation ([@bib0405]). These data demonstrate that nsp1β blocks ISGF3 nuclear translocation to inhibit JAK-STAT signaling via inducing KPNA1 degradation and that the residue valine-19 in nsp1β correlates with the inhibition. Besides nsp1β, other PRRSV proteins including nsp7, nsp12, GP3 and N also inhibit IFN-induced downstream signaling, albeit at a smaller scale ([@bib0400]). The N protein inhibits IFN-activated signaling by blocking STAT1 nuclear translocation ([@bib0400]). Among PRRSV strains, there are variable effects on the IFN-activated JAK-STAT signaling. In MARC-145 cells, PRRSV strains VR-2385, VR-2332, NVSL97-7895, and Lelystad, but not MN184, block the activity of exogenous IFN-α ([@bib0400]). In primary PAMs, strain VR-2385, VR-2332, MN184, and Lelystad, but not NVSL, inhibit the activity of IFN-α. For NVSL97-7895 and MN184, the same virus infection in MARC-145 and PAM cells has variable effects on the IFN-activated signaling. This is not totally unexpected as NVSL strain differs from other PRRSV strains in its failure to induce IL-10 expression *in vivo* ([@bib0345]). These two strains might have alternative interacting mechanisms with the JAK-STAT signaling in the two types of cells. 2.2. PRRSV inhibits JAK-STAT3 signaling {#sec0035} --------------------------------------- Among all the STAT proteins, STAT3 is known as highly pleiotropic in mediating the expression of a variety of genes in response to both cytokines and growth factors, and thus plays a pivotal role in numerous cellular processes including cell survival, proliferation, embryogenesis, and immune responses ([@bib0205], [@bib0445]). Thus STAT3 has been found to be the target of some viral pathogens. Measles virus V protein inhibits IL-6 mediated STAT3 signaling ([@bib0370]). V protein of mumps virus prevents responses to IL-6 and v-Src by inducing STAT3 ubiquitination and degradation ([@bib0375]). Rabies virus interferon antagonist P protein inhibits gp130 receptor signaling by interacting with activated STAT3 ([@bib0230]). Inhibition of STAT3 signaling by these viruses and PRRSV can lead to inhibition of a broad spectrum of cytokines and growth factors to thwart host antiviral responses and allow virus replication and spread *in vivo*. OSM, a member of the IL-6 family activating JAK-STAT3 signaling, enhances the antiviral effects of IFN-α and plays a role in the induction of an adaptive immune response to pathogens ([@bib0175], [@bib0215]). Treatment of MARC-145 cells with OSM alone leads to inhibition of PRRSV replication ([@bib0455]). To overcome the inhibition, PRRSV uses a strategy to reduce STAT3 protein level. PRRSV infection of MARC-145 cells and primary PAMs leads to significant reduction of STAT3, whereas it has minimum effect on STAT1 protein level ([@bib0455]). Several PRRSV strains tested induce a similar reduction of STAT3 protein level but have no effect on its transcript level. Treatment of the PRRSV-infected cells with MG-132, a proteasomal inhibitor, restores the STAT3 level. The further study identifies that PRRSV nsp5 induces the STAT3 degradation, shown by increased polyubiquitination level and shortened half-life ([@bib0455]). As a result, nsp5 inhibited STAT3 signaling. Further study is being undertaken to elucidate the mechanism. 2.3. PRRSV interference with other STATs and JAKs {#sec0040} ------------------------------------------------- As aforementioned, other STATs also have important roles in the host immune response. Besides inhibiting JAK-STAT1/STAT2 and JAK-STAT3 signaling, PRRSV might interfere with other STATs. Our preliminary study shows that PRRSV reduces STAT2 and STAT6 protein level (unpublished result). Further study is being undertaken to delineate the mechanisms. A recent study shows that PRRSV upregulates a host microRNA, miR-30c, which is a negative regulator by targeting JAK1 ([@bib0465]). PRRSV reduces JAK1 expression in infected cells and is expected to affect the phosphorylation of both STAT1 and STAT2. But in our studies, IFN-induced phosphorylation of both STAT1 and STAT2 in PRRSV-infected MARC-145 cells was not affected ([@bib0290]). It may play a role *in vivo* as PRRSV infection in pigs leads to elevation of miR-30c in lungs and PAMs and its level corresponds to the viral load ([@bib0465]). This indicates that PRRSV has multiple strategies to block host IFN-signaling. 3. Perspective {#sec0045} ============== PRRSV uses multiple strategies to evade the host innate and adaptive immunity. By interfering with the JAK-STAT signaling, PRRSV may perturb the function of cytokines in the regulation of the host immune response. 3.1. PRRSV and IFN-mediated JAK-STAT signaling {#sec0050} ---------------------------------------------- IFNs are essential for antiviral response and targeted by PRRSV at multiple levels ranging from the induction of IFNs, IFN-activated JAK-STAT signaling, to ISGs. PRRSV interference of IFN induction has been reviewed elsewhere ([@bib0350], [@bib0395]). The modulation of innate immunity by nsp1 is conserved in all members of *Arteriviridae* ([@bib0150]). PRRSV also interferes with ISGs, for example, nsp2 inhibits ISG15 by reducing its production and counteracting its conjugation to cellular proteins ([@bib0355]). PRRSV downregulates interferon-induced double-strand RNA-activated protein kinase (PKR) at its early infection of PAMs ([@bib0440]). PRRSV counteracts interferon-induced transmembrane protein 1 (IFITM1) and Tetherin in MARC-145 cells by nsp3 and E proteins, respectively, ([@bib0415]). It is expected that PRRSV may antagonize other ISGs that restrict the virus entry, replication, and spread. The JAK-STAT signaling is modulated by host suppressive signals, such as suppressors of cytokine signaling (SOCS) proteins, ubiquitin carboxy-terminal hydrolase 18 (USP18), and miRNAs ([@bib0080], [@bib0180]). PRRSV upregulates the suppressive signals to antagonize JAK-STAT pathway. For example, PRRSV infection leads to upregulation of SOCS1 ([@bib0430]); PRRSV upregulates miRNA miR-30c against JAK1 ([@bib0465]). But overexpression of USP18 leads to a reduction of PRRSV replication ([@bib0005]). Further study needs to be done to determine the mechanism. The combined effect of multiple perturbations by PRRSV results in efficient PRRSV replication and invasion, and consequently, contributes to the poor induction of protective immune response. Minimizing the interference is expected to improve the host immune response to PRRSV infection. Indeed, PRRSV strain A2MC2, which induces type I IFNs in infected cells *in vitro* and has no inhibitory effect on IFN signaling ([@bib0260]), elicits higher virus-neutralizing antibodies than the MLV in pigs ([@bib0410]). Site-directed mutagenesis of R128 and R129 of nsp1β reduced its inhibition of IFN induction and leads to improvement of innate and adaptive immune responses ([@bib0220]). 3.2. PRRSV antagonizes JAK-STAT3 signaling pathway {#sec0055} -------------------------------------------------- As mentioned above, STAT3 has pleiotropic activity and plays important roles in many biological processes. STAT3 is a central regulator of lymphocyte differentiation and function ([@bib0190]). STAT3 is needed for activation and maturation of dendritic cells (DCs) and plasmacytoid DCs are considered to be the major source of IFN-α production during viral infection. STAT3 deficiency affects the generation of memory CD8^+^ T cells ([@bib0085], [@bib0335]) and memory B cells ([@bib0015], [@bib0095]). PRRSV infection induces a weak cell-mediated immune response, in which PRRSV-specific T cells transiently appears two weeks after infection without a change in frequencies of CD4^+^ and CD8^+^ T-cells ([@bib0435]). The STAT3 antagonizing may be one of the reasons for PRRSV interference with the development of protective immune response. PRRSV inhibits STAT3 signaling by inducing degradation of STAT3 but has minimum effect on STAT1 protein level ([@bib0455]). This reduction appears to be an intrinsic property of PRRSV as both Type 1 and 2 PRRSV strains are able to downregulate STAT3. PRRSV infection in pigs leads to elevation of IL-10 ([@bib0070], [@bib0360]) and induces lung lesions with inflammatory cell infiltration ([@bib0145]). IL-10 signaling via mediator STAT3 results in the generation of regulatory macrophages, which have an anti-inflammatory activity to dampen immunopathology. PRRSV antagonizing STAT3 signaling could interfere with the IL-10 regulatory function and leads to dysregulation of inflammation. PRRSV nsp5 is responsible for the STAT3 reduction. Nsp5 is a hydrophobic transmembrane protein and can possibly form a membranous structure in the cytoplasm that could be the site for PRRSV replication ([@bib0235]). No direct interaction between nsp5 and STAT3 is identified, which suggests that nsp5 might activate an E3 ligase of STAT3. Further study will reveal the mechanism of the induction of STAT3 degradation. 3.3. PRRSV's effect on STAT2/5/6 signaling {#sec0060} ------------------------------------------ As aforementioned, other than STAT1 and STAT3, other STAT proteins have also been shown to be significant for the host immune response. STAT2 is involved in STAT1-independent signaling by interacting with IRF9 to drive the expression of ISRE-containing genes ([@bib0035], [@bib0110]). As PRRSV reduces STAT2 protein, we expect it inhibits the STAT1-independent antiviral signaling. PRRSV's effect on the signaling of STAT4, STAT5 and STAT6 has not been determined yet. The main target cells for PRRSV infection are certain lineages of monocytes/macrophages *in vivo*. The PRRSV effect on JAK-STAT signaling in T cells would be indirect, such as by exosomes from infected cells ([@bib0130], [@bib0250]). But its interference of the JAK-STAT signaling in infected macrophages would have significant consequence as the response of PAMs against viral or bacterial pathogens is critical in determining the outcome of infection in the host. Cytokines like IFN-γ and GM-CSF activate JAK-STAT signaling to regulate macrophage phenotype and activation ([@bib0170]). Activated macrophages secrete immune regulatory cytokines including IL-1β, IL-6, IL-12, TNF-α and so on ([@bib0115]). STAT6 has been demonstrated to have JAK-independent antiviral signaling ([@bib0065]). PRRSV is expected to inhibit this alternative STAT6 signaling, which may contribute to the PRRSV evasion. Indeed, PRRSV reduces STAT6 protein level in infected MARC-145 cells (unpublished result). Further study will examine the mechanisms of the interference of STAT6 signaling. 4. Conclusion {#sec0065} ============= In conclusion, PRRSV perturbs JAK-STAT signaling pathways by disturbing STATs protein level and their nuclear translocation. PRRSV inhibits IFN-activated JAK-STAT signaling by blocking nuclear translocation of ISGF3 ([@bib0290], [@bib0405]). Recently, we discovered that PRRSV inhibits JAK-STAT3 signaling via inducing degradation of the STAT3 protein ([@bib0455]). We also noticed that STAT2 and STAT6 protein levels were much lower in PRRSV-infected cells than uninfected controls (unpublished results). PRRSV interaction with the JAK-STAT signaling pathways is complex and consequences would be possibly depending on the context of the milieu during infection. Despite substantial efforts to study and control PRRS, no production or vaccination regimen has demonstrated sustaining success ([@bib0310], [@bib0315]). This is likely in part due to the PRRSV poor induction of protective immune response, allowing for PRRSV replication, spread, and persistence in infected populations. Elucidation of the mechanisms of PRRSV evasion of JAK-STAT signaling would yield insightful information, which may facilitate the development of improved vaccines or therapeutics against PRRSV and other pathogens. Conflicts of interest {#sec0070} ===================== None. This study was partially funded by the National Pork Board and internal fund of the University of Maryland.

id: dsq-747531936 date: 2010-04-05T22:49:24.0000000-07:00 name: DonSleza4e avatar: https://disqus.com/api/users/avatars/DonSleza4e.jpg message: <p>Awesome<br>Integrated lib with my <a href="http://asp.net" rel="nofollow noopener" title="asp.net">asp.net</a> mvc project ^^</p>

#include <bits/stdc++.h> #define sd(x) scanf("%d",&x) #define sd2(x,y) scanf("%d%d",&x,&y) #define sd3(x,y,z) scanf("%d%d%d",&x,&y,&z) #define fi first #define se second #define pb(x) push_back(x) #define mp(x,y) make_pair(x,y) #define LET(x, a) __typeof(a) x(a) #define foreach(it, v) for(LET(it, v.begin()); it != v.end(); it++) #define _ ios_base::sync_with_stdio(false);cin.tie(NULL);cout.tie(NULL); #define __ freopen("input.txt","r",stdin);freopen("output.txt","w",stdout); #define func __FUNCTION__ #define line __LINE__ using namespace std; template<typename S, typename T> ostream& operator<<(ostream& out, pair<S, T> const& p){out<<'('<<p.fi<<", "<<p.se<<')'; return out;} template<typename T> ostream& operator<<(ostream& out, vector<T> const & v){ int l = v.size(); for(int i = 0; i < l-1; i++) out<<v[i]<<' '; if(l>0) out<<v[l-1]; return out;} void tr(){cout << endl;} template<typename S, typename ... Strings> void tr(S x, const Strings&... rest){cout<<x<<' ';tr(rest...);} const int N = 100100; int n, p; int l[N], r[N]; int main(){ sd2(n,p); for(int i = 0; i < n; i++){ sd2(l[i], r[i]); } l[n] = l[0]; r[n] = r[0]; long double res = 0; for(int i = 1; i <= n; i++){ long long v1 = (r[i]/p) - ((l[i]-1)/p); long long v2 = (r[i-1]/p) - ((l[i-1]-1)/p); long long l1 = r[i]-l[i]+1; long long l2 = r[i-1]-l[i-1]+1; long long t = (l1-v1)*(l2-v2); long double p = (long double) t / (long double) (l1*l2); p = 1.0f-p; res += p*2000; } printf("%.9lf\n", (double)res); return 0; }

3 Md. App. 266 (1968) 238 A.2d 920 MELVIN HENRY GREEN v. WARDEN, MARYLAND HOUSE OF CORRECTION. No. 102, September Term, 1967. Court of Special Appeals of Maryland. Decided February 28, 1968. Before MURPHY, C.J., and ANDERSON, MORTON, ORTH, and THOMPSON, JJ. PER CURIAM: This is an application for leave to appeal from an order filed on July 21, 1967, by Judge Robert I.H. Hammerman, sitting *268 in the Criminal Court of Baltimore, denying relief sought under the Uniform Post Conviction Procedure Act. As stated by Judge Hammerman in his memorandum opinion, the applicant raised the following contentions: 1. That petitioner was the subject of an illegal arrest for the reasons that: a. He was not a resident of the house in which he was arrested, b. The police had no probable cause to arrest him, c. That the narcotics were found in the hall of the home in which he was arrested and he was charged with their possession. 2. That the police gave perjured testimony at the time of trial. 3. That he was not properly represented by his court appointed lawyer. Judge Hammerman stated that: "Petitioner's counsel conceded at the outset and at the conclusion of the hearing that the first two grounds were not proper subjects for review on Post Conviction, that she understood that these issues were raised at the time of trial, and that she was not pressing them at this time." The mere fact of an illegal arrest is not grounds for relief under the Uniform Post Conviction Procedure Act, Slater v. Warden, 233 Md. 609, as the legality of the arrest is immaterial where no fruits of the arrest are introduced into evidence at the trial against the accused; Ogle v. Warden, 236 Md. 425, but where the petitioner alleges, as he seems to do in this case, that evidence was seized as a result of the illegal arrest, this constitutes an allegation of an illegal search and seizure and may properly be raised under the Act. Davis v. Warden, 232 Md. 670; Fennell v. Warden. 236 Md. 423; Austin v. Director, 237 Md. 314. Since this issue was not pressed at the hearing, it can be considered as abandoned. Szukiewicz v. Warden, 1 Md. App. 61. However, we note that the lower court found that there was nothing in the testimony of the applicant to indicate *269 that his arrest was illegal. Since applicant did not carry his burden of proof, the arrest must be considered as legal. Thus, the allegation of an illegal search and seizure would also fail since further evidence to support this contention was not offered. Judge Hammerman states that the rule as to incompetence of counsel is "that it is only when the representation is so deficient as to make a farce out of the trial that an accused is entitled to a new trial." Although this was the former rule in Maryland, the Court of Appeals has expanded this rule in Slater v. Warden, 241 Md. 668, so as to give a more comprehensive definition to that rule. The more preferable rule now is that counsel is incompetent when under all the circumstances of the particular case the petitioner has not been afforded "a genuine and effective representation." Turner v. State, 303 F.2d 507 (4th Cir.1962); Turner v. State, 318 F.2d 852 (4th Cir.1963); Slater v. Warden, supra; Jones v. Warden, 244 Md. 720; Nash v. Warden, 243 Md. 700. This is the rule that is now being followed by the Maryland Court of Special Appeals. Groh v. Warden, 1 Md. App. 674; Charles v. State, 1 Md. App. 222; Norris v. Warden, 1 Md. App. 69; Cherrix v. Warden, 1 Md. App. 65. However, even under this more comprehensive rule, the trial counsel for applicant was not incompetent. Judge Hammerman found that "the court clearly does not find that (counsel) was in any way incompetent or negligent in the performance of his duties as attorney for the petitioner. Quite the contrary in the case. The court feels that (counsel) did a more than adequate job in defending the petitioner, as the testimony clearly demonstrates." As to the second contention, we accept the lower court's finding that this was a bald allegation as no evidence was offered to support it at the hearing. Thus it cannot constitute grounds for relief. McCoy v. Warden, 1 Md. App. 108. Application denied.

School Level After eight hours of casting and touching a creature of little or no intelligence, the creature would gain average intelligence (compared to humanoids) and learn the language of the caster. Plants also gained the ability to move their "limbs". The creature was effectively charmed by the caster for thirty days; after that, the creature could chose to stay or turn hostile to the caster.

Demonstration of scrotal disease on bone scintigraphy. The identification of scrotal disease on a bone scan is reportedly rare. Most previous reports involve abnormally increased accumulation of radioisotope in the scrotal region. This article includes a compilation of three cases of incidental scrotal photopenic defects on bone scintigraphy and a brief review of the literature.

Q: ASP.NET Response.Redirect( ) Error Here is my code: try { Session["CuponeNO"] = txtCode.Text; txtCode.Text = string.Empty; Response.Redirect("~/Membership/UserRegistration.aspx"); } catch(Exception ex) { string s = ex.ToString(); lblMessage1.Text = "Error Occured!"; } I am getting an error, even though it redirects after catch. Here is the error: "System.Threading.ThreadAbortException: Thread was being aborted.\r\n at System.Threading.Thread.AbortInternal()\r\n at System.Threading.Thread.Abort(Object stateInfo)\r\n at System.Web.HttpResponse.End()\r\n at System.Web.HttpResponse.Redirect(String url, Boolean endResponse)\r\n at System.Web.HttpResponse.Redirect(String url)\r\n Can anyone tell me why this error is occurring? A: You could simply move .... Response.Redirect("~/Membership/UserRegistration.aspx"); ... outside of the Try / Catch block or you can try John S. Reid's newer solution below : Response.Redirect(url) ThreadAbortException Solution by John S. ReidMarch 31, 2004(edited October 28, 2006 to include greater detail and fix some inaccuracies in my analysis, though the solution at it's core remains the same) ... skipping down ... The ThreadAbortException is thrown when you make a call to Response.Redirect(url) because the system aborts processing of the current web page thread after it sends the redirect to the response stream. Response.Redirect(url) actually makes a call to Response.End() internally, and it's Response.End() that calls Thread.Abort() which bubbles up the stack to end the thread. Under rare circumstances the call to Response.End() actually doesn't call Thread.Abort(), but instead calls HttpApplication.CompleteRequest(). (See this Microsoft Support article for details and a hint at the solution.) ... skipping down ... PostBack and Render Solutions? Overrides. The idea is to create a class level variable that flags if the Page should terminate and then check the variable prior to processing your events or rendering your page. This flag should be set after the call to HttpApplication.CompleteRequest(). You can place the check for this value in every PostBack event or rendering block but that can be tedious and prone to errors, so I would recommend just overriding the RaisePostBackEvent and Render methods as in the code sample1 below: private bool m_bIsTerminating = false; protected void Page_Load(object sender, EventArgs e) { if (WeNeedToRedirect == true) { Response.Redirect(url, false); HttpContext.Current.ApplicationInstance.CompleteRequest(); m_bIsTerminating = true; // Remember to end the method here if there is more code in it. return; } } protected override void RaisePostBackEvent ( IPostBackEventHandler sourceControl, string eventArgument ) { if (m_bIsTerminating == false) base.RaisePostBackEvent(sourceControl, eventArgument); } protected override void Render(HtmlTextWriter writer) { if (m_bIsTerminating == false) base.Render(writer); } The Final Analysis Initially I had recommended that you should simply replace all of your calls to Response.Redirect(url) with the Response.Redirect(url, false) and CompleteRequest() calls, but if you want to avoid postback processing and html rendering you'll need to add the overrides as well. From my recent in depth analysis of the code I can see that the most efficient way to redirect and end processing is to use the Response.Redirect(url) method and let the thread be aborted all the way up the stack, but if this exception is causing you grief as it does in many circumstances then the solution here is the next best thing. It should also be noted that the Server.Transfer() method suffers from the same issue since it calls Response.End() internally. The good news is that it can be solved in the same way by using the solution above and replacing the call to Response.Redirect() with Server.Execute(). 1 - I modified the code formatting to make it fit inside SO boundaries so it wouldn't scroll.

This invention relates generally to a portable humidifier and, more specifically, to a portable humidifier with an improved water tank. Various types of humidifiers are used to provide moisture to indoor air. Included among such humidifiers are ultrasonic humidifiers, steam humidifiers or vaporizers, and evaporative humidifiers. Ultrasonic humidifiers employ a high-speed oscillator, positioned a given distance below the water surface, to energize the water and break it into a fine mist. A fan carries the mist into the surrounding environment. It is critical that the distance from the oscillator to the water level be accurately maintained to ensure that the oscillation energy is efficiently transferred to the water. A drop in water level can result in permanent damage to the oscillator. The water level generally is maintained by the use of an inverted water tank such as that described in U.S. Pat. Nos. 5,210,818 and 5,247,604. The tank is sealed and includes a carrying handle on its top surface while a bottom surface includes an opening to which a cap is attached. When the tank is inverted beneath a spigot and the cap is removed the opening serves as a fill opening. Often the cap includes a valve system which seals the fill opening unless the tank is properly positioned on a humidifier base and the valve is engaged by a valve actuator in the base. The valve actuator opens the valve and allows water to escape from the tank into a reservoir defined by the base. Discharging water is exchanged for air which enters the tank through the same opening. As water flows into the base reservoir, the water level rises until it seals the valve and prevents air from getting into the tank. At this level, which is the normal operating water level for the humidifier, water flow from the tank ceases. The design of the humidifier is established to position the oscillator that given distance below this level. As the oscillator and fan cause dispersal of moisture from the reservoir, the water level attempts to drop creating a pathway for air into the tank and in turn allowing the release of a proportional amount of water from the tank into the reservoir to thereby return the water level to the normal operating level. This process repeats itself continually until the water supply in the tank is depleted, at which time the water level begins to drop increasingly lower. A float sensing shut-off switch mechanism senses the abnormally low water level and turns the humidifier off before the water level drops low enough to cause damage to the oscillator. This basic system is well known and often practiced in ultrasonic humidifiers of the prior art. Evaporative humidifiers come in several varieties. Some employ absorbent belts continuously rotating through first a water reservoir and then an air stream to cause humidity. Some employ pumps to lift water from a reservoir and pour it over a porous media through which air flows to cause similar humidification, and some employ wicking pads which are positioned partially below water level and partially above. In such humidifiers, the water level must be maintained for a different reason than that of the ultrasonic humidifier. Specifically, it is important that water level be maintained to ensure consistent humidity efficiency and maximum moisture output. Wick pads generally are capable of drawing water from the reservoir water level to a given height through capillary action. A relatively smaller portion of the wick pad must be positioned below the water level where water is absorbed, than above where air flowing through the pad causes the desired humidification. Excessive height of the pad above that height to which water will be drawn not only constitutes wasted wick material and is therefor inefficient by design, but also reduces the humidification efficiency of the humidifier by allowing a pathway for air which does not pass through the moistened portion of the pad, essentially constituting air leakage which reduces the total humidification rate. For this reason, wick type evaporative humidifiers are often designed to maintain a given water level which ensures that the most efficient amount of the wick pad lies above and below the water level to maximize efficiency and output. Accordingly, a water tank similar to that described above often is used with evaporative humidifiers. Steam humidifiers cause humidity by boiling water into vapor. A submersible heating element depends from a humidification unit into a boiling chamber within a base. A water tank similar to that described above is positioned on the base to both feed water to the boiling chamber and to maintain a given normal operating level therein. The boiling water maintains the temperature of the heating element at approximately two hundred and twelve degrees fahrenheit. It is important that the water level be maintained high enough to fully submerge the heating element, and not be allowed to drop while the heating element is energized or overheating will occur. A float sensing shut-off switch mechanism senses an abnormally low water level as the water tank is depleted and turns the heating element off before excessive overheating occurs. Most of the tanks described above and known in the prior art include a handle projecting from a tank top surface. Such positioning of the handle requires that the tank be carried from the humidifier to the spigot cap with the fill opening facing down. It is common for some leakage to occur from the cap during such movement. It is also common that, after being carried to a water supply, the tanks are rested on a surface with the fill opening facing down. Although usually protruding precariously from the bottom surface of the tank, prior cap/valve assemblies have not generally provided a great amount of structural support, and being that a filled water tank is relatively heavy, the weight of the tank resting on the cap/valve assembly can subject the valve to an enormously high amount of stress. Consequently, permanent damage to valves is relatively common and often results in water spillage that damages furnishings. It is the object of the present invention to overcome the deficiencies of the prior art and provide a humidifier tank having a tank support structure which serves both to protect the delicate cap/valve assembly and provides a means by which the tank can be carried hole side up to prevent leakage during transport.

Q: Removing the default pages when adding a domain via Plesk whenever I add a new domain into my new Plesk control panel on my dedicated server it creates a whole bunch of test files in the cgi-bin, httpdocs and httpsdocs. There must be some setting somewhere where I can tell Plesk not to do this? I've done a good Google search but must now turn to the StackOverflow masses :) Yours, Chris A: Ok I've found it (and feel a bit stupid!) /var/www/vhosts/.skel/0/ Hope that helps someone :)

The temps have finally trended under 100 degrees in Arizona and parts of the nation are already getting downright chilly. Hooray for sweater and jacket weather! It's the most fashionable season in our opinion. Cuts are tailored and sophisticated, fabrics are rich and textured, and layering is where it's at! On NBC Channel 12's Arizona Midday, Angela walked us through the latest in key layering pieces from Vida Moulin boutique, and shared style hacks on how to get creative and create the perfect layered look to transition into fall. For questions on the looks pictured below or on Arizona Midday, please email ...Read more. Fact: If you ask a random group of women what their favorite season is for fashion, the majority will enthusiastically respond -- fall, of course!! Why? Well, fall styles are notorious for their sophistication, tailoring, luxe accents, and rich textured fabrics. Yum! And, who doesn't love to layer? Fall gives the fashion lover lots of room for styling and customization. The Fall 2019 collections are an impressive mix of classics like precision-cut tailored suits and separates, a variety of animal prints (especially leopard and python) and cozy knits. On the trendier side, we're seeing an '80s and '90s resurgence - ...Read more. We're seeing an extra dose of '80s glam mixed with '90s edge in the fall collections this season, from sequins and satin to patent leather and utility chic. All luxe, very wearable and easy to mix and style. Sequins for day? YES! Moto jacket for evening? YES! On Channel 3's Your Life Arizona, Angela shows us some of the latest fall trends we'll be featuring at our 4th annual “Sip, Shop & Style” event on September 27th at Saks Fifth Avenue, plus how to take them from day to night. The gorgeous outfits on the show are from Saks Fifth Avenue at Biltmore Fashion Park. Plus, makeup artist Lisa Moore ...Read more. YASSSSS!! It's time for our 4th annual Sip, Shop & Style event hosted by Saks Fifth Avenue and Mom Style Lab! And, we're excited to have ICONIC magazine join us as a media sponsor this year! This event just keeps getting bigger and better. Boots, sweaters and fall decor are popping up in stores, signaling that fall is so close we can almost taste our first pumpkin spice latte of the season... oh wait, it's already on the menu at Starbucks. It may be a little too toasty where you live to don a sweater yet, but you can start embracing fall colors and transitioning to booties. Hmmmmm.... we LOVE fall and all its ...Read more. Every year we travel to Seattle for several weeks to visit family and escape the heat in Phoenix, but it had been years since I'd been to Victoria, British Columbia. I decided to take Christina up on the Victoria Clipper to see the beautiful city and stay at the Fairmont Empress, which presides regally over Victoria Harbor. Known for its history and world-famous high tea, staying at the Empress has been on my bucket list for years. Plus, we have relatives in the area, so it was a terrific opportunity for some quality family time. All in all, we had a wonderful, memorable trip and can't wait to go back! Leaving ...Read more. Back-to-school time is exciting, nerve-wracking, invigorating and emotional all at the same for both parents and kids. Whether your child is starting kindergarten or middle school, picking up some new outfits that your kids feel confident in is an important part of the process. Involving your child in the shopping -- if they let you -- is a good idea, since it gives them an opportunity to express their style and individuality. Of course, some kids are more interested in their wardrobe than others, and many wear uniforms, which puts the focus on shoes and accessories. We turned to locally-owned boutique for both moms and ...Read more.

It wasn’t long ago that Germany was considered one of the few countries with a stable political situation. On the surface at least, with high economic growth and a dominant position within Europe, everything seemed to be going well for the German ruling class. However, this stability is turning into its opposite. On Sunday, 14 January 2018, tens-of-thousands of activists from different labour and left-wing organisations came to the Berlin Socialist Memorial Cemetery in the Eastern suburb of Friedrichsfelde to commemorate the murder of the outstanding German revolutionaries and Marxists Rosa Luxemburg and Karl Liebknecht on 15 January 1919. Early on Monday morning, 20 November, the leaders of the German, right-wing, liberal Free Democratic Party (FDP) suddenly declared their exit from preliminary coalition talks and walked out of the room. The negotiations with Chancellor Angela Merkel`s Christian Democrats and their Bavarian sister party Christian Social Union (CDU/CSU) and the Greens had been going on for nearly five weeks. A political earthquake is the best way we can describe the federal elections that took place in Germany on Sunday, September 24. For the first time ever in post-war history an extreme right-wing party has been elected to the Bundestag (federal parliament). At the same time the parties that formed the “Grand Coalition” lead by Chancellor Angela Merkel since 2003 have suffered historic defeats. On Monday, a truck ploughing through a crowded Christmas market at Breitscheidplatz in Berlin highlighted once again the mess that has been created in the Middle East by imperialist meddling. Twelve victims are believed to have been killed while 49 have been injured. The perpetrator of this crime had hijacked the truck from a Polish driver whom he subsequently killed. After the attack, he fled the scene and is still unaccounted for.

OUR WORK To truly see if MP is the right firm to partner with for your project, you should take a look at the successful projects that we have undertaken. The real value of our firm is the expertise and experience that we can bring to you. Biloxi Athletic Building, Biloxi, MS The Biloxi Public School District hired M|P Design Group to design a new state of the art athletic facility at Biloxi High School. The facility totals 10,000 sq. ft. consisting of a large weight lifting area, cheerleading room, locker rooms, shower area and a storage area. The new athletic facility will be utilized by the football, baseball, softball, soccer and track teams. M | P performed the architectural design, structural design, electrical & mechanical design, as well as the civil design for this project. M | P provided the construction administration services for this project.

Work Would be Great Without the Coworkers The French philosopher Jean-Paul Satre once famously said, “Hell is other people.” I’m not sure who poor old (unfortunate) Jean-Paul’s neighbors, friends, or coworkers (people who work at the same place you do) were, but obviously they were not exactly ideal (perfect; the best possible). There’s no question (no doubt) that getting along with other people can be difficult, especially when you are at your job. A recent article tried to look on the bright side (focus on the positive) of bothersome (causing trouble) coworkers and suggest ways that these types of people can actually be helpful. I’m not sure if I’m buying that argument (am convinced; agree), but I thought I’d talk about a few common terms used for these difficult types of coworkers in the U.S. Perhaps you know someone who fits (is similar to) one of these descriptions: A social butterfly is a person who likes to talk a lot, be around other people, attend parties and other social events, and meet and know a lot of people. A gossip is someone who likes to talk about other people, even if what he says isn’t true. You can have a social butterfly who just likes to chat (talk informally), but who may also be a gossip. A workaholic is someone who works too much, and is always thinking about work, even when not working. Malcontents are people who are generally unhappy and who may find ways to do things they are not supposed to do, or may express their unhappiness in other ways. Someone who is passive-aggressive is someone who shows her unhappiness in small ways, rather than confronting (meeting face-to-face or openly) the person who is making her unhappy. A passive-aggressive person might misplace (lose temporarily) important papers, not return your phone calls, or “forget” to do the things she promised to do for you. So, it’s possible for someone to be a malcontent who is passive-aggressive. Even worse, this person could be a workaholic who is a passive-aggressive malcontent! A narcissist is someone who believes everything should be focused on him or her, believing his or her own ideas, views, and beliefs are the most important. A person who is a narcissist might attract people who are suck-ups. A suck-up is willing to say or do things — such as compliment someone a lot or say how great he is — to get an advantage in the workplace. Backstabbers are people who pretend to be friendly with you, but make critical (disapproving) comments or do things to harm you when you’re not around. Who do you think are the most disruptive (interfere with your work or cause the most problems) where you work: social butterflies, gossips, workaholics, narcissists, malcontents, suck-ups, backstabbers, or passive-aggressive people? 26 Responses to Work Would be Great Without the Coworkers There are these kind of jewelleries every place you could be working and every one of them are really a good piece to be off from them if it could be possible but some time it is not. I think one of the most disruptive could be the passive-agressive that usually is also adorn with other virtues like gossip and suck-up. Working in a large place for years, being with dozens of chaps and women every day I have met every kind of these jewelleries inside the office, but what is even worst could be that this kind of people usually have the hability of going up from their position and get what they really want just to be a boss because in fact they cannot do another thing as gossip, suck-up, or backstabber. The common rule should be that fair workers or persons don´t get anything more than too much work every moment. My best dear Jeff, you are a fair good worker without any of these attributes that you have mentioned above, that´s for sure. A piece of paper, a line, at the right side all the negative things about a subject, a place, a decision, a trip, or which ever other matter you need to think on. On the right side all the positive things of the same subject, decision or question. Read all carefully, think on all the negative and the positive things about the matter you need to have a resolution and act accordingly with the result, or not, but you already know the PROS AND CONTRAS ( in Spanish) of the subject. I have done that execise several times along my life, but never about a person, I love or want the person or not, to me that is enough. Cuca an me are watching a new TV serial “Breaking Bad” (one of the best I could remember) and on the second or third episode the protagonist take a paper and make a list that way. It could be one of the few occasions I have watched that on the TV., he has taken a man he thinks wants to kill him, he cannot advise the police and have to decide if he kill the man or not, so take a paper and write all the negative and the positive things of taken his resolution. I am not going to tell you the end, see the serial that is incredible good. I love what Cuca tells us about the themes or stories that she has, itself, to make life easier, sleep, do not think about their future, not thinking about their disease, multiple sclerosis , that have no cure. Ultimately we could all, we know that we must die soon, today, tomorrow, or in a few years. Get sick if we are healthy, and if we ailments, with more reason to live today the present. Cuca gives us a practical example of our destructive thoughts away and have incentives to entertain our intellect. She tells us nice or comical real stories of the men and women who were living hundred of years ago and all of them are so interesting that have a great success in the “gatufo´s blog”, till the point some time emiliano/gatufo. is jealous with her exit. (it could be good to put some of them here in the ESL blog with Jeff´s permiss that sure he gives me) +++++ Second and most important point, reflect on what we are humans. Yes, the second point to ponder here is much more difficult and painful than the first. What happens to human beings? No second day someone dies not massacred, murdered, raped, by one or more other human beings. Humans beings themselves massacred by fellow like them. The other living things of this world kill to eat, or to survive, we kill us humans? Which purpose or we have in our minds to assassinate each other. To crush the weak, the innocent, invent the worst destructive weapons imaginable. Was started with a stone, a stick, a jawbone of an ox or lamb, and so have been used increasingly, knives, swords, spears, arrows, maces, fire, stones, boiling oil, rifles, guns, planes, missiles and even gas mass murder our neighbors. It is a malignant virus that is within our existence that makes us so aggressive, violent, butchers, with ourselves and our neighbors? It is said that God made us in his image and likeness, that mystery is to doubt amazing and frankly, can not be that the image or likeness of God, the supreme being all goodness, you can be the man throughout his existence. Evil, murders, wars, famine and so continue. Humans never learn? Goodness is inside the human soul, of course, thankfully, but there are many doses of evil, violence, mindless aggression leads to kill our neighbors that we do not know, that finally, since such an attitude leads repeatedly million times, today, yesterday, and thousands of years before. We have the gift of speech but not talk to our neighbors, our brothers, we can write and we do not, we can reason and not reason. Simply kill to impose our criteria, for fun, for amusement, for simple and clear evil. And most of the time by ambition, power and money. We forget that we die, sooner than later, and to live well and in peace treasure not need wealth, power and hatred. The world is plunged into extreme violence of the human race, as always, destroys itself and other living things, as long as all this for what purpose? I myself look inside myself and I know I can be violent in other circumstances, in other religious or dictatorial environments. Nobody can understand what is happening today, yesterday, or tomorrow. We’ll finish everything that exists? Could be. I have no explanation for this, nobody does, extreme good and evil that is the human being. Good Samaritan, good father, good mother, and cruel murderer simultaneously if need be. Who can understand? More to the questions “to be or not to be that is the question” or “who I am, where I come to where I’m going”, we might think that we do so much damage to our neighbors and ourselves, while we are charitable, solidarity patients. Frankly it is very difficult to understand ourselves. But life, death, kindness, sadism and violence continue today in any part of the globe, and particularly in certain areas called “hot” of a lifetime. They fight, they kill, die innocent and this continues more. Happen as usual, about the last years in Iraq, Afghanistan, Palestine, Lebanon, and many other countries. Well, frequently I think on these subjects, but what could be done? Humans are what they are along history, destroy everything they touch but even kill their humans brother without reason and any profit to their souls or the kind of life it is supposed to have. History follows always in the same way, the world if full with last examples of wars, destructions and pain. I tend to agree with your title “Work Would be Great Without the Coworkers”, especially if we have to spend time together with Backstabbers, gossip, malcontents, narcissist, passive-aggressive, social butterfly, suck-up and workaholic. In fact, these kinds of people don’t just exist in our work place, they are everywhere – at home, at work, even a stranger like a sales person could suddenly tells you how horrible her mother-in-law is. There is a saying in Hong Kong: one type of rice feeds hundred types of people. We are all different. I would try to avoid those people who are bothersome. I would like to thank you again Jeff for using this opportunity to teach us more special terms to describe those kinds of people. It is useful to know the use of them. I believe that the best way to get along with the people of these categories is to know their inner world and expectations. Let me clarify my point. A social butterfly is a good mixer who mingles with people easily. Consequently, he can give good advice on how to throw parties, prepare brilliant speeches and do presentations. If I, for example, ask for his wise tips, he will definitely wish to help me because he is an expert in this field. As a result, we will establish a steady long-term relation. By asking for his wise advice, I will boost his self-confidence and self-esteem. In return, I will improve my communication skills. It’s a win-win situation. Moving on to a Gossip, he knows much about the coworkers, their problems and strong and weak points. If I want, for instance, to resolve a conflict with someone or clarify misunderstanding then I can come up to the gossip and ask everything about the person I am about to talk to. After hearing him out, I will be able to set the best strategy to tackle some problems. Besides, I can ask the gossip to get some important information about somebody for me. I bet the gossip will be glad to reveal his true talent. Again, it’s a win-win situation. If a Malcontent bothers you, then you can download a video on crippled and mentally ill people from YouTube who are looking for some sponsors. Explain to him that these people are more miserable than him and need his help. Then, ask him to make a donation or provide them with any possible help. Next, always ask him whether he has done it or not. He will end up contacting you. If it doesn’t work, you can say that there is always some stink coming out of his mouth. He should see the doctor ASAP. Eventually, you will get rid of him. Keep a distance from Backstabbers. Keep your conversations with him to the minimum. The less he knows about you the less vulnerable you are. If you have to deal with narcissist, a few penny compliments will make him happy. Highlight his importance in the company and point at his unique approach to tackling various problems. Don’t overdo, of course. Otherwise, you will be considered as a Suck-up. Jeff’s post provoked so many thoughts that I am writing again. I do not see any problem with that. There is so many white space just waiting to be filled. I am trying to looking at the picture from a different side here. With these individuals it is not all pain and negativity, they also make the world different, less boring and various. So, I am pleased with their presence. Just as an example, without them, there would not be this same post! we would be here complaining about how perfect we are. I do not want to work in a place that looks like the covers of the Jehovah’s witness publications of paradise on earth where you see everyone smiling and the kids play with lions. Maybe that yes, I mean playing with lions, I would like that. So, I am glad there are such individuals around. Personally, at the workplace I experience lots of fun. We are all relatively young and there is abundance of joking around and jerks to make fun of. Answering Jeff’s question, I would say that the most disruptive person is the woman that instead of working goes b@#£@ing around. I could be wrong about that, but geez …women can be disruptive just like hurricanes. Don’t you guys agree? Hi! I like the psychological topic even if I always have a guiltiness feeling. I think we all are a little narcissist, a little gossip, a little backstabber. This is the human nature. I look at the little children. They don’t know to lie and their parents must teach them not to have bad manners with their mates, having a good bahaviour. Because of many troubles, failures from our own life we can harm work place life or even productivity. We start to envy, to hate anyone, especially the success persons. Or simply, we were born with these “manners”. Hi! With regard to the bosses…I agree with the mentioned article. “The narcissists are terrible listeners and apt to gobble up all the credit. Many bosses are narcissists. Take care ensuring that the narcissist doesn’t rule your work life.” One of my bosses was very gossip, backstabber, very, very narcissist, but workaholic and clever. We have sometimes to tolerate some “sins”, if it is possible. Hi! Dear Neal, you are a new comer I think. Glad to meet you. Thank you for your very good advices. For sure you are talking from a boss view point. A good boss must know to use all his employees abilities and “sins” for his profit. And I agree with you: the less he knows about you the less vulnerable you are. This was one of the first advices received when I started to work: don’t talk too much about you. Thank you. Hi! Dear Emiliano, I am reading with interest every thing you are writing. I was worried about you said: around February/ March I began to regain my life again. I’m not really a believer but I pray to God when I lose hope. I do the same, too. I wish you all the best. Hi! Work would be great without the coworkers… I don’t know what to say… I have had the oportunity to work alone in an office. It was quiet, pleasant, but I was isolated from the rest of the coworkers. As I am a lonely person, being and isolated…you can imagine how nice it was. Neal, my eyes are opening wide reading your post as it is wise, absolutely wise and certain. I think you have given us such good advises that I can only said you ¡BRAVO¡ they are really nice and incredible wise advises what you have written in the post. Reminds me what my wife Cuca use to do in her common life, she is really an intelligent wise person just in living without problems with other, family or wich eve other person who could be beside her. I am not so, I am a fighting man that says just what me have not to say being so frank and crude (some times) that seems I am looking for problems every where or moment. To persons like you and Cuca I only could say, Bravo, that is the right attitude to be happier, Neal sincerely yours emiliano. A stimulating issue,I guess.After reading this,some kind of faces,faces of my coworkers, have come out of my mind immediately. some of them are more or less like Jeff said.And it seems to me that a suck-up may disturb me a lot,which could be called ‘friendly-looking tiger’ in China,I guess. But there is a saying in my country,all rivers run into sea because it has wide heart and is capable of embracing all.We are not sea though,we could still learn to sea and try our best not to be influenced by those kind of persons. Anyway,I guess we are not perfect as well and we sometimes are more or less like them. So thinking of more positive sides of people would do good to all of us. Dear Tania, I don´t know if these poems have been here in this land of peace before but again they are here, just for you dear friend. My Love Without wanted, without feeling it nearly without being concious I fell in love. Thin, nice, beautiful crazy girl, we were living the sixties. Deluded years from one generation that confused everything. Love, miracle daily bright that enlight my entire life. After fourty years or more of living, without feeling them being together. Today I still fell in love with you once and again till I´ll die. Depression I am not the same I felt yesterday. Changed without knowing why? It is today what let me empty? Ideas come and go without any sense Thoughts incessant that drill the head Not hopes only awaiting everything go by Be you I say, but so another day Going after chimeras that vanish There is not any sense or hopes just wait One and another day, waiting for what Dead without doubts, easy relax for ever Sleep, not to think, not to suffer, not await Sleep for ever, at the end rest perhaps? Who knows? life it is a not sense being so when there is not will to continue Only rest is the time, today only rest is my will. ++++ Yes, they are quite different, but some time sadness gives a way of inspiration, don´t you think so dear? Hi! Dear Emiliano, very nice poems! I consider them a spring present for me. Thank you. I copy all your poems in a special notebook. I copy to remember them and all good thoughts from all our blog friends who address me.

// RUN: %clang_cc1 -emit-llvm -triple i386-apple-macosx10.7.2 < %s | FileCheck %s // The preferred alignment for a long long on x86-32 is 8; make sure the // alloca for x uses that alignment. int test (long long x) { return (int)x; } // CHECK-LABEL: define i32 @test // CHECK: alloca i64, align 8 // Make sure we honor the aligned attribute. struct X { int x,y,z,a; }; int test2(struct X x __attribute((aligned(16)))) { return x.z; } // CHECK-LABEL: define i32 @test2 // CHECK: alloca %struct._Z1X, align 16

Q: Pattern Lab with second package.json I have a Pattern Lab edition-node-gulp set up and would like to use NPM to manage UI dependencies, like jQuery, D3 and others. Pattern Lab is set up so that development happens in a 'Source' folder, which is complied and moved to a 'Public' folder. The root of the Public folder becomes the root of the application when served. Currently, I include assets like jQuery and others manually. I think it would be great to manage dependencies like jQuery right in the package.json file used to run all of Pattern Lab Node, but the node_modules folder exists outside of Public, so I can not reference it in the live application. So far, it seems that I have two options: Continue as is, and forget package management for these assets. Create a second package.json inside Public with jQuery and others, which seems sloppy. Is creating a second package.json so bad? Am I failing to consider some other option? A: Creating a second package.json is not that bad (when you know what and how you are doing of course). However in your particular case it is not the best scenario because there are way better options. What is the problem? Adding the assets to the build output. So, what you can do: install the assets via npm install and save them in the original package.json adapt gulpfile.js to copy the files in the output directory. If the second step step is too hacky / problematic it could be also replaced with simple package.json scripts change (add build script): "scripts": { "gulp": "gulp -- ", "build": "npm run gulp && cp -R node_modules/jquery/dist/blablabla.js mypublicdir/blablabla.js" }, and then run it as npm run build. If you need to support Windows you can use https://www.npmjs.com/package/cp-cli instead of cp.

Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine. D-eritadenine (DEA) is a potent inhibitor (IC(50) = 7 nm) of S-adenosyl-l-homocysteine hydrolase (AdoHcyase). Unlike cyclic sugar Ado analogue inhibitors, including mechanism-based inhibitors, DEA is an acyclic sugar Ado analogue, and the C2' and C3' have opposite chirality to those of the cyclic sugar Ado inhibitors. Crystal structures of DEA alone and in complex with AdoHcyase have been determined to elucidate the DEA binding scheme to AdoHcyase. The DEA-complexed structure has been analyzed by comparing it with two structures of AdoHcyase complexed with cyclic sugar Ado analogues. The DEA-complexed structure has a closed conformation, and the DEA is located near the bound NAD(+). However, a UV absorption measurement shows that DEA is not oxidized by the bound NAD(+), indicating that the open-closed conformational change of AdoHcyase is due to the substrate/inhibitor binding, not the oxidation state of the bound NAD. The adenine ring of DEA is recognized by four essential hydrogen bonds as observed in the cyclic sugar Ado complexes. The hydrogen bond network around the acyclic sugar moiety indicates that DEA is more tightly connected to the protein than the cyclic sugar Ado analogues. The C3'-H of DEA is pointed toward C4 of the bound NAD(+) (C3'...C4 = 3.7 A), suggesting some interaction between DEA and NAD(+). By placing DEA into the active site of the open structure, the major forces to stabilize the closed conformation of AdoHcyase are identified as the hydrogen bonds between the backbone of His-352 and the adenine ring, and the C3'-H...C4 interaction. DEA has been believed to be an inactivator of AdoHcyase, but this study indicates that DEA is a reversible inhibitor. On the basis of the complexed structure, selective inhibitors of AdoHcyase have been designed.

Anthony Iluobe Chief Anthony Iluobe (JP) was born in 1945 to the family of Chief and Mrs Joseph Agimhelen Iluobe (JP) of Ivue-Uromi of the Uromi Kingdom in Edo State. He is the owner, managing director and chief executive officer of Iluobe Oil and Gas Marketing Co. Ltd. He studied Engineering in Japan. He was previously the Chairman of Edo State Water Board. He was previously the Chairman of Independent Petroleum Marketers of Nigeria (IPMAN) Edo state Chapter. He is the father of Patrick Eromosele Iluobe, the minority leader of the Edo State House of Assembly. He is also the eldest brother of the jeweller Chris Aire. He lives in Edo State where he presides over his various business investments including Antilu Oil and Gas Ltd. He is married to Magistrate Martina U. Iluobe, The chief Magistrate II of Edo State and the presiding Magistrate of the Customary Court in Ekpoma, Edo State. References Category:1945 births Category:Living people Category:Edo people

818 F.2d 878 Comegysv.V.A. 87-3018 United States Court of Appeals,Federal Circuit. 1/26/87 MSPB, 31 M.S.P.R. 293 VACATED AND REMANDED

MadagascarThe rich neon blue color in apatite is often due to the presence of rare earth elements or by natural iridiation. This attractive sphere, having many "gemmy" areas, would make a fine decorative statement in any home or office interior. weight: 15.71 kilos. diameter 8in This auction is now finished. If you are interested in consigning in future auctions, please contact the specialist department. If you have queries about lots purchased in this auction, please contact customer services. Buyers' Obligations ALL BIDDERS MUST AGREE THAT THEY HAVE READ AND UNDERSTOOD BONHAMS' CONDITIONS OF SALE AND AGREE TO BE BOUND BY THEM, AND AGREE TO PAY THE BUYER'S PREMIUM AND ANY OTHER CHARGES MENTIONED IN THE NOTICE TO BIDDERS. THIS AFFECTS THE BIDDERS LEGAL RIGHTS. If you have any complaints or questions about the Conditions of Sale, please contact your nearest customer services team. Buyers' Premium and Charges Buyer's Premium Rates25% on the first $150,000 of the Hammer Price20% from $150,001 to $3,000,000 of the Hammer Price12% on the excess over $3,000,001 of the Hammer Price Payment Notices Payment for purchases may be made in or by (a) cash, (b) cashier's check or money order, (c) personal check with approved credit drawn on a U.S. bank, (d) wire transfer or other immediate bank transfer, or (e) Visa, MasterCard, American Express or Discover credit, charge or debit card. A processing fee will be assessed on any returned checks. Please note that the amount of cash notes and cash equivalents that can be accepted from a given purchaser may be limited. Shipping Notices For information and estimates on domestic and international shipping as well as export licences please contact Bonhams Shipping Department.

J-S55030-18 2019 PA Super 59 COMMONWEALTH OF PENNSYLVANIA IN THE SUPERIOR COURT OF PENNSYLVANIA Appellee v. PRINCE ISAAC Appellant No. 389 EDA 2018 Appeal from the PCRA Order Entered December 21, 2017 In the Court of Common Pleas of Chester County Criminal Division at No: CP-15-CR-0002120-2007 BEFORE: OLSON, STABILE, JJ., and FORD ELLIOTT, P.J.E. OPINION BY STABILE, J.: FILED FEBRUARY 26, 2019 Appellant, Prince Isaac, appeals from the December 21, 2017 order denying relief pursuant to the Post Conviction Relief Act (“PCRA”), 42 Pa.C.S.A. §§ 9541-46. We affirm. Appellant represented himself at trial after a defective waiver-of-counsel colloquy—the trial court never apprised Appellant of the elements of the charged offenses.1 Appointed direct appeal counsel did not raise this issue. On collateral review, Appellant claimed direct appeal counsel rendered ____________________________________________ 1 “To ensure that the defendant’s waiver of the right to counsel is knowing, voluntary, and intelligent, the judge […] shall elicit […] that the defendant understands the nature of the charges against the defendant and the elements of each of those charges[.]” Pa.R.Crim.P. 121(A)(2)(b). J-S55030-18 ineffective assistance. The PCRA court originally denied relief, but a three- judge panel of this Court reversed, concluding that the defective waiver colloquy was an issue of arguable merit.2 We remanded to the PCRA court for an assessment of counsel’s strategy and the prejudice, if any, to Appellant. The PCRA court once again denied relief, and this timely appeal followed. The prior panel quoted the underlying facts: [Appellant] and his brother and co-conspirator, Shamek Hynson [(Hynson)], had a powerful motive to kill the victim, Omar Reid [(the victim)], on October 18, 2004. The murder was an act of retaliation against [the victim] for an incident involving another one of their brothers—Ramek Neal—that took place nearly one year earlier. On November 5, 2003, at approximately 10:30 p.m., Neal and another individual broke into [the victim’s] apartment at 416 Victoria Drive, in the Regency Park complex located in Coatesville, Chester County, Pennsylvania. Neal brandished a pistol while demanding [the victim’s] property. [The victim] fought back and in self-defense shot Neal, leaving Neal paralyzed from the neck down. This November 2003 incident was the subject of subsequent family meetings attended by both [Appellant] and Hynson. On October 18, 2004, at approximately 11:00 p.m., [Appellant] drove Hynson to [the victim’s] apartment at 416 Victoria Drive in a Kia automobile that had been taken from a couple in Lancaster, Pennsylvania, to be used in the murder. Hynson got out of the Kia and knocked on [the victim]’s front door. As [the victim] opened the door, Hynson asked, “Are you Omar?” and then shot [the victim] six times. Shell casings were ejected from Hynson’s pistol and left at the murder scene. [The victim] collapsed and died on top of his five-year-old son, who had been on the living room floor near the front door. After the shooting, [Appellant] gestured to Hynson, from inside the Kia, to “hurry up.” This was observed by a witness looking out the window of her ____________________________________________ 2 We affirmed the PCRA court’s denial of relief on Appellant’s remaining issues, and our Supreme Court denied allowance of appeal. Direct appeal counsel’s handling of the waiver colloquy is the sole remaining issue. -2- J-S55030-18 apartment. Hynson ran to the Kia, which was waiting for him with the front passenger’s door open. After Hynson got into the Kia, he closed the door, and [Appellant] sped away from the scene. A police officer happened to be driving into the Regency Park complex when a 911 dispatcher advised him of the shooting. The officer spotted the Kia and gave chase. During the chase, the murder weapon—a Hi-Point .380—was thrown from the car into the brush next to a railroad track. Due to the wet roadway, [Appellant] lost control and crashed the Kia into a ditch. [Appellant] and Hynson fled in different directions, and neither was apprehended by police at that time. Other individuals in [Appellant’s] Buick Riviera (another getaway vehicle) had been waiting, as planned, near the Regency Park complex and observed the police chasing the Kia to the location in Coatesville where [Appellant] had earlier switched from driving his own car, the Buick, and begun driving the Kia. They picked up Hynson, and Hynson told them that he had “just shot a man,” that he and [Appellant] were being chased, and that [Appellant] was still running from the police. Hynson and others then drove around Coatesville looking for [Appellant] and trying to find the gun that had been “tossed” during the getaway chase. Neither [Appellant] nor the gun was located, so they visited Ramek Neal to advise him of what happened and then returned to Lancaster. [Appellant] also made his way back to Lancaster. When he arrived, he was wet, he had a gash on his head, and his clothing was ripped. [Appellant] told his friends that, while being chased by the police, he had crashed the Kia and then had to run on foot. [Appellant’s] fingerprints were found on the interior driver’s door window of the crashed Kia. DNA testing confirmed the presence of Hynson’s blood on the interior passenger’s side of the Kia. Gunshot residue was also found inside the Kia. The murder weapon was found almost a year later by a woman walking her dog near the railroad tracks along [Appellant’s] escape route. That weapon was traced back to a straw purchase in North Carolina made by Tolanda Williams, the mother of Hynson’s child. Williams testified that during the week before the murder, she went with [Appellant] and Hynson to several pawn and gun shops in [Appellant’s] Buick, to be the straw purchaser of guns. The tag number of [Appellant’s] Buick was written down by one of the shop owners who became suspicious of one of the transactions. -3- J-S55030-18 During cross-examination, the gun shop owner identified [Appellant] as the driver of the Buick. The Hi-Point .380 murder weapon was also used by Hynson to shoot Edward Cameron in Lancaster at approximately 4:30 p.m. on October 18, 2004—less than seven hours before [the victim] was murdered in Coatesville. Shell casings from the two shootings were all matched to the Hi- Point .380 found along the escape route. Cell phone records indicated that [Appellant’s] cell phone was active and used in the Coatesville area during and after the time of the murder. Isaac, 2016 WL 5210891, at *1–2. At the conclusion of a six-day trial, the jury found Appellant guilty of first-degree murder and conspiracy. On July 8, 2009, the trial court sentenced Appellant to life in prison. This Court affirmed the judgment of sentence on direct appeal, and our Supreme Court denied allowance of appeal on August 12, 2012. Appellant filed this timely first PCRA petition on November 12, 2013.3 Presently, Appellant argues the PCRA court erred because counsel had no reasonable strategic basis for failing to raise the inadequate waiver colloquy on direct appeal, and because Appellant would have received a new trial had counsel challenged the defective waiver colloquy. Appellant’s Brief at 4. In PCRA appeals, our scope of review is limited to the findings of the PCRA court and the evidence on the record of the PCRA court’s hearing, viewed in the light most favorable to the prevailing party. Because most PCRA appeals involve questions of fact and law, we employ a mixed standard of review. We defer to the PCRA court’s factual findings and credibility determinations supported by the record. In contrast, we review the PCRA court’s legal conclusions de novo. ____________________________________________ 3 Pursuant to 42 Pa.C.S.A. § 9545(b)(1) and SUP CT. R. 13, the timeliness deadline was November 13, 2013. -4- J-S55030-18 Commonwealth v. Reyes-Rodriguez, 111 A.3d 775, 779 (Pa. Super. 2015) (en banc). Counsel is presumed effective, and a PCRA petitioner asserting otherwise bears the burden of proof. Id. at 779-80. Specifically, the petitioner must prove by a preponderance of the evidence that (1) the underlying claim is of arguable merit; (2) counsel had no reasonable strategic basis in support of the action or inaction; and (3) the petitioner suffered prejudice, i.e., the outcome of the proceeding in question would have been different but for counsel’s error. Id. at 780. A petitioner’s failure to prove any one of these three prongs is fatal to the claim. Id. The right to counsel is guaranteed by the Sixth Amendment to the United States Constitution and Article V, Section 9 of the Pennsylvania Constitution. Commonwealth v. Clyburn, 42 A.3d 296, 298 (Pa. Super. 2012).4 When a defendant wishes to waive the right to counsel, the trial court is “ultimately responsible for ensuring that the defendant is questioned about the six areas [specified in Rule 121] and for determining whether the defendant is indeed making an informed and independent decision to waive counsel.” Commonwealth v. Davido, 868 A.2d 431, 437 (Pa. 2005) (quoting Commonwealth v. McDonough, 812 A.2d 504, 508 (Pa. 2002)), cert. denied, 546 U.S. 1020 (2005). Specifically, “it is incumbent on the ____________________________________________ 4 This Court decided Clyburn two days before our affirmance of Appellant’s judgment of sentence on direct appeal. Thus, it was not available to appellate counsel when she filed her Pa.R.A.P. 1925(b). Nonetheless, Clyburn relied on precedents. -5- J-S55030-18 court to fully advise the accused [of the nature and elements of the crime] before accepting waiver of counsel.” Clyburn, 42 A.3d at 299 (quoting Commonwealth ex rel. Clinger v. Russell, 213 A.2d 100, 102 (Pa. Super. 1965)) (brackets added in Clyburn). A “penetrating and comprehensive colloquy” is mandatory, regardless of the defendant’s experience with the system. Id. at 300 (quoting Commonwealth v. Owens, 750 A.2d 872, 876 (Pa. Super. 2000)). “Failure to conduct a thorough, on-the-record colloquy before allowing a defendant to proceed to trial pro se constitutes reversible error” on direct appeal. Id. A defendant also has a constitutional right to self-representation. Clyburn, 42 A.3d at 298; United States v. Isaac, 655 F.3d 148, 153 (3d Cir. 2011), cert. denied, 566 U.S. 1029 (2012). This right prevents the Commonwealth from bringing a defendant into court and forcing a lawyer on him. Commonwealth v. Starr, 664 A.2d 1326, 1334-35 (1995). In other words, the right to counsel is intended as “an aid to a wiling defendant—not an organ of the State interposed between an unwilling defendant and his right to defend himself personally.” Commonwealth v. Tejada, 188 A.3d 1288, 1295 (Pa. Super. 2018) (quoting Faretta v. California, 422 U.S. 806, 820 (1975)). We now turn to the facts of this case. The remand record reveals that Appellant was uncooperative during two separate waiver colloquies. At the first one, on September 18, 2008, Appellant repeatedly refused to answer the -6- J-S55030-18 trial court’s colloquy questions because he believed the court lacked jurisdiction over him. N.T. Hearing, 9/18/2008, at 15-22. Appellant’s uncooperative behavior led the trial court to have him gagged. Id. at 27. Eventually, the gag was removed and the trial court attempted a colloquy. Appellant stated that he did not know the elements of criminal homicide, and that he was unable to list the elements of the charged offenses. Id. at 43, 56. The trial court did not explain the elements to Appellant. Ultimately, the court denied Appellant’s request to represent himself based on Appellant’s insufficient understanding of the law. Id. at 59-62. At the second hearing, on October 2, 2008, Appellant repeatedly referred to an “affidavit of specific negative averment” that he apparently attempted to file and serve on the trial court, among others. N.T. Hearing, 10/2/2008, at 6-8. Appellant apparently believed that the trial court’s “default” in failing to respond to his affidavit rendered the criminal proceedings against him invalid. Id. at 10. Despite Appellant’s failure to cooperate with a waiver colloquy the trial court granted Appellant’s request to represent himself. Id. at 29. The court noted that Appellant’s stated, at the September 18, 2008 hearing, that he did not understand the elements of the charged offenses. Id. at 31. Even so, the court did not describe the elements of the charged offenses to Appellant. At the May 5, 2017 PCRA hearing ordered by the previous panel of this Court, direct appellate counsel, Brenda Jones, testified that her appointment -7- J-S55030-18 began in 2007. N.T. Hearing, 5/2/17, at 10. Another appointed attorney was first chair, and Jones was to serve as death penalty counsel. Id. Jones remembered the waiver colloquies as contentious. Id. at 12. Jones testified that Appellant was adamant about his decision to represent himself: [THE COURT:] On the basis of your knowledge of [Appellant] and at the time of the second hearing, on his waiver of counsel, do you believe that if I as the trial judge had specifically outlined each and every element of each and every charge against him, that he would have under those circumstances changed his mind about wanting to represent himself? [JONES]: Your Honor, no. I always thought that he wanted to represent himself, Judge. I never thought—I would say, this is my opinion, that it wouldn’t have made any difference. THE COURT: Okay. When you were observing him during the course of the, at least the second hearing on self- representation, when combined with the first hearing on self- representation, how adamant was he on a scale of one to ten, ten being the highest and most adamant, about representing himself? [JONES]: Your Honor, I would say he was a ten. Id. at 20. Procedurally, Jones was appointed to represent Appellant after he filed a pro se notice of appeal and a pro se Pa.R.A.P. 1925(b) statement. Id. at 18. Jones filed a motion for an extension of time to file a supplemental statement, pending completion of transcripts. Id. The trial court granted one such motion, but did not grant a second extension while Jones was still awaiting several transcripts, including the waiver colloquy transcripts. Id. at 18, 25, 28. In any event, Jones testified that she recalled from her presence at the September 18 and October 2, 2007 hearings that Appellant was not -8- J-S55030-18 aware of the elements of the charged offenses. Id. at 30. On appeal, Jones challenged Appellant’s competency to represent himself, rather than the validity of the colloquy. Id. at 32-33. She believed his nonresponsive answers to the trial court’s questions and his concern with matters irrelevant to his defense called his competency into question. Id. at 33. This Court found the competency issue waived for lack of an objection at trial. Commonwealth v. Isaac, 46 A.3d 830 (Pa. Super. 2012) (unpublished memorandum, at 10); appeal denied, 50 A.3d 125 (Pa. 2012). We also noted that Appellant did not specifically challenge the validity of the waiver colloquy. Id. For this reason, the previous collateral review panel of this Court concluded Appellant has not previously litigated the issue before us. See Isaac, 2016 WL 5210891, unpublished memorandum at *3-4. The PCRA court found that the record was unclear as to counsel’s strategic basis for not challenging the waiver colloquy.5 The PCRA court found Appellant’s failure to prove prejudice dispositive. PCRA Opinion, 12/21/2017, at 3. Ultimately, we agree. Therefore, we will focus our analysis on this element. In Commonwealth v. Pou, ___ A.3d ____, 2018 WL 4925254 (Pa. Super. October 11, 2018), this Court considered circumstances similar to the ____________________________________________ 5 The PCRA court did not make any finding on counsel’s strategy, noting only that “[t]he testimony offered by appellate counsel at the hearing of May 2, 2017 did not conclusively answer this question. PCRA Court Opinion, 12/21/17, at 3. -9- J-S55030-18 instant case—the appellant waived his right to counsel at trial after a defective colloquy and appointed direct appeal counsel failed to raise the issue. In Pou, the trial court failed to apprise the appellant of the applicable statutory maximum sentences or inquire into his age, educational background, and ability to comprehend the proceedings. Id. at *1-2. There, as here, a panel of this Court found the issue to be of arguable merit and remanded for further proceedings after the PCRA court denied relief without a hearing. Id. *2. On remand, the PCRA court found that counsel had a reasonable strategic basis for choosing not to raise the issue, but this Court rejected that argument on appeal. Id. at *3. Instead, we concluded the petitioner failed to demonstrate prejudice even though the petitioner would have received a new trial had counsel challenged the Rule 121 colloquy on direct appeal. Id. at *4. “The failure to raise that claim was doubtlessly prejudicial, but as we shall explain it does not rise to the level of Pierce prejudice.” Id. The reference is to Commonwealth v. Pierce, 527 A.2d 973 (Pa. 1987), wherein the Pennsylvania Supreme Court articulated the three-prong ineffective assistance of counsel analysis, in accord with the United States Supreme Court’s opinion in Strickland v. Washington, 466 U.S. 668 (1984). As set forth above, a PCRA petitioner must normally plead and prove that counsel’s error was prejudicial within the meaning of Pierce. In limited circumstances, pursuant to United States v. Cronic, 466 U.S. 648 (1984), prejudice can be presumed on collateral review. - 10 - J-S55030-18 The Pou Court relied on Weaver v. Massachusetts, 137 S.Ct. 1899 (2017), in which the United States Supreme Court explained that an error that would invalidate a conviction on direct appeal need not necessarily do so on collateral review. In Weaver, the defendant argued that trial counsel was ineffective for failing to object to the trial court’s order closing the courtroom to the public. Id. at 1905-06. Had counsel raised the issue on direct appeal, the defendant would have received a new trial. Id. On collateral review, however, the Weaver Court held that the petitioner failed to demonstrate prejudice: As explained above, not every public-trial violation will in fact lead to a fundamentally unfair trial. Nor can it be said that the failure to object to a public-trial violation always deprives the defendant of a reasonable probability of a different outcome. Thus, when a defendant raises a public-trial violation via an ineffective-assistance-of-counsel claim, Strickland prejudice is not shown automatically. Instead, the burden is on the defendant to show either a reasonable probability of a different outcome in his or her case or, as the Court has assumed for these purposes, […] to show that the particular public-trial violation was so serious as to render his or her trial fundamentally unfair. Id. at 1911 (internal citations omitted). Consistent with Weaver, the Pennsylvania Supreme Court has held on several occasions that the absence of harmless error for purposes of direct appeal does not equate to presumed prejudice on collateral review. In Commonwealth v. Reaves, 923 A.2d 1119 (Pa. 2007), the trial court failed to comply with Rule 708(C)(2) of the Rules of Criminal Procedure, which requires the trial court to state on the record its reasons for the sentence it - 11 - J-S55030-18 imposes after a violation of probation (“VOP”). Id. at 1129; Pa.R.Crim.P. 708(C)(2). The Supreme Court noted that, “in a direct review context, Rule 708 operates in a fashion which is not unlike Cronic; prejudice (or rather the absence of harmless error) will be presumed from the failure to comply.” Id. at 1129-30. Once a Rule 708 procedural complaint has been waived, however, and a derivative claim is raised under the guise of ineffective assistance of counsel, there is no reason to presume Sixth Amendment, Strickland prejudice from the VOP court’s unobjected-to failure to comply with Rule 708. Derivative claims of ineffective assistance of counsel are analytically distinct from the defaulted direct review claims that were (or could have been) raised on direct appeal. Commonwealth v. Collins, 585 Pa. 45, 888 A.2d 564, 572–73 (2005). As noted, Strickland requires a showing of actual prejudice, not the presumed prejudice arising from Cronic, nor the harmless error standard that governs ordinary claims of trial court error on direct review, nor the presumption of harm arising on direct review of Rule 708 claims. This Court has long recognized the distinction between Strickland prejudice and the harmless error standard applicable in the direct review context, and this distinction can be outcome- determinative. Id. at 1130. Likewise, in Commonwealth v. Mallory, 941 A.2d 686 (Pa. 2008), cert. denied, 555 U.S. 884 (2008), our Supreme Court refused to presume prejudice where the trial court failed to conduct an oral colloquy before permitting the defendants to waive their right to a jury trial pursuant to Pa.R.Crim.P. 620. The Mallory Court also explained the distinction between a waiver colloquy and the underlying right. “A waiver colloquy is a procedural - 12 - J-S55030-18 device; it is not a constitutional end or a constitutional ‘right.’” Id. at 697. Further, “[A]n on-the-record colloquy is a useful procedural tool whenever the waiver of any significant right is at issue, constitutional or otherwise, e.g. waiver of a trial, waiver of the right to counsel, waiver of the right to call witnesses, waiver of the right to cross-examine witnesses, waiver of rules-based speedy trial time limits, etc. But the colloquy does not share the same status as the right itself. Id. (emphasis added). The Supreme Court reasoned that a constitutional, structural error creating presumed prejudice under Cronic would have occurred if, for example, a timely jury trial demand was wrongly denied. Id. at 697. Counsel’s effectiveness during a waiver colloquy, on the other hand, is “far removed” from a structural constitutional error. Id. On collateral review, therefore, when the issue is counsel’s effectiveness, a “presumptively-valid waiver […] must be analyzed like any other ineffectiveness claim.” Id. at 698. That is, the prejudice analysis must encompass the “totality of relevant circumstances.” Id. In the context of a jury trial waiver, those circumstances could include “the defendant’s knowledge of and experience with jury trials, his explicit written waiver (if any), and the content of relevant off-the-record instructions counsel had with his client.” Id. The defendant must show that his understanding of the jury waiver was impaired by counsel’s performance, and that he would have elected a jury but for counsel’s performance. Id. at 702. - 13 - J-S55030-18 Later, in Commonwealth v. Spotz, 18 A.3d 244 (Pa. 2011), the PCRA petitioner challenged counsel’s failure to object to a defective waiver of counsel colloquy. The Supreme Court held that, “[t]o establish prejudice, the petitioner must demonstrate a reasonable probability that but for counsel’s ineffectiveness, he would not have waived the right at issue.” Id. at 263-64. We now turn back to Pou, which, like the instant matter, concerned appellate counsel’s failure to raise a defective waiver colloquy on direct appeal. We acknowledged there was “no doubt” the petitioner would have received a new trial had counsel raised the issue on direct appeal. Id. at *6. Consistent with Weaver and our State Supreme Court precedents, however, we concluded the technical deficiency under Rule 121 was not sufficient, in and of itself, to establish prejudice on collateral review. Id. at 7-8. That is, the trial court’s failure to comply with the technicalities of a rule does not amount to a structural error warranting presumed prejudice. Id. The United States Constitution requires that a defendant “be made aware of the dangers and disadvantages of self-representation, so that the record will establish that ‘he knows what he is doing and his choice is made with eyes open.’” Id. at *9 (quoting Faretta, 422 U.S. at 835). Therefore, “Rule 121 goes farther than what the United States Constitution requires” and “a technically-deficient - 14 - J-S55030-18 waiver of counsel colloquy is not the same as a constitutionally deficient waiver of counsel.” Id.6 Instantly, Appellant relies on case law governing direct review. Without expressly acknowledging it, he presents this case as one involving structural error and presumed prejudice pursuant to Cronic. Specifically, Appellant’s reliance on Clyburn is misplaced. There, the trial court failed to inform the defendant of the charges against him and the elements of each of those charges. Clyburn, 42 A.3d at 301. This Court therefore found itself “constrained” to hold that the defendant’s waiver of counsel was invalid, and that “the failure to explain the elements of the charged crimes requires us to vacate the judgment of sentence.” Id. (citing Commonwealth v. Houtz, 856 A.2d 119, 130 (Pa. Super. 2004)). As Clyburn was decided on direct appeal, it is inapposite. As was the case in Pou, Appellant fails to distinguish between a technically deficient waiver colloquy and a constitutionally deficient waiver ____________________________________________ 6 We observe that, in Commonwealth v. Meehan, 628 A.2d 1151 (Pa. Super. 1993), appeal denied, 649 A.2d 670 (Pa. 1994), this Court held that, on collateral review, the PCRA court need not conduct a full colloquy before permitting the petitioner to waive counsel, as several of the mandatory inquiries are inapplicable on collateral review (Meehan was decided under Rule 318, the predecessor to current Rule 121). The Meehan Court noted the petitioner’s failure to assert “that he would not have waived his right to counsel if more specific inquiry had been made into the relevant areas.” Id. at 1159. Meehan is not directly applicable here because it governs a petitioner’s statutory right to counsel on collateral review. - 15 - J-S55030-18 colloquy, and he does not argue that the instant case presents an example of the latter. The deprivation of the colloquy, as we have already explained, does not share the same status as the deprivation of the right itself. Mallory, 941 A.2d at 697. Under Mallory, a structural error would have occurred here if, for example, Appellant demanded and was refused counsel. In fact, Appellant had two appointed lawyers representing him when he insisted on his right to self-representation and failed to cooperate with the trial court’s Rule 121 colloquy.7 ____________________________________________ 7 Regarding Appellant’s behavior at the colloquies, the PCRA court cited Commonwealth v. Bastone, 467 A.2d 1339 (Pa. Super. 1983), in which the defendant was unrepresented by counsel at his preliminary hearing. This Court considered former Rule 318(b), which required a knowing, intelligent, and voluntary waiver before a defendant proceed without counsel at a preliminary hearing. The trial court attempted to conduct a waiver colloquy, but the defendant refused to answer questions, refused to sign a written colloquy, and eventually turned his back to the judge. This Court wrote: We believe that appellant’s contemptuous behavior constituted a knowing, voluntary and intelligent waiver of counsel. To require a written waiver in a case such as this could create a ‘Catch-22’ situation in that a ‘court-wise’ criminal defendant could continually appear in court without counsel on the date scheduled for his trial but refuse to execute a written waiver of his right to counsel making it impossible to proceed with his trial. Obviously, such a situation would render the judicial system a mockery. Id. at 1341. Further, this Court found that any error was harmless because the defendant failed to explain how he was prejudiced by the absence of counsel at a preliminary hearing. Id. - 16 - J-S55030-18 In light of the foregoing, we conclude Appellant is not entitled to relief. Order affirmed. Judgment Entered. Joseph D. Seletyn, Esq. Prothonotary Date: 2/26/19 ____________________________________________ The “Catch-22” problem does not arise here because Appellant had appointed counsel. Further, given Appellant’s failure to attempt to prove prejudice in accord with the cases discussed in the main text, we need not decide whether Bastone, decided under Rule 318, applies with equal force to Rule 121. Likewise, we need not consider the Commonwealth’s assertion that Appellant’s behavior resulted in forfeiture of his right to counsel. - 17 - 

Most normal human cells undergo a limited number of cell divisions, eventually entering an irreversibly arrested state, through either senescence or differentiation. Both processes have major implications for human health; between them impacting birth defects, cancer and the degenerative effects of human aging. For example, defects in cell differentiation during embryo development result in human birth defects. Senescence and differentiation programs are both characterized by profound changes in chromatin structure, and, in both cases, this is thought to contribute to the altered cell phenotype. We are using senescence as a model system to study these changes in chromatin structure and their contribution to two hallmarks of both senescence and terminal differentiation, repression of proliferation-promoting genes and cell cycle exit. Recently, we showed that the chromatin regulatory protein, HIRA, and its physical binding partner, ASF1a, both play a key role in formation of a novel chromatin structure in senescent cells, called senescence associated heterochromatin foci (SAHF). SAHF is thought to silence genes that drive cell proliferation. HIRA and ASF1a drive SAHF formation, acting in concert with a subnuclear organelle, the PML body; and two chromatin associated proteins, HP1 and macroH2A. Preliminary data indicate that the HIRA/ASF1a pathway is activated by the key proliferation-regulating kinase, GSK3. To understand the physiological significance and molecular basis of SAHF formation and its mode of activation in presenescent cells, we will use cell and molecular biology techniques to: Specific Aim 1. Investigate the structure of SAHF, its mechanism of assembly by HIRA/ASF1a and PML nuclear bodies and identify its key growth suppressor components. Specific Aim 2. Investigate the function and mechanism of incorporation into SAHF of chromatin associated proteins, HP1 and macroH2A. Specific Aim 3. Investigate the role of GSK3 activity in localization of HIRA to PML bodies, formation of SAHF and onset of senescence.

. List the prime factors of i. 3, 37 Let l be (12/(-10))/(3/50). Let q = 85 + l. What are the prime factors of q? 5, 13 Let y(o) = -12*o - 47. Let r(d) = -12*d - 46. Let x(b) = 3*r(b) - 2*y(b). List the prime factors of x(-14). 2, 31 Let r be ((-6)/(-33) + (-120)/176)*22. What are the prime factors of ((-44)/(-8))/r + 110/4? 3 Let v = 836 - 612. List the prime factors of v. 2, 7 Suppose 2*h - 35 = -3*h. Suppose h = -q + 24. Let z(l) = l**3 - 18*l**2 + 18*l - 11. What are the prime factors of z(q)? 2, 3 Let b(i) = -6*i + 26. Suppose 0 = -3*x + 2*h - 25, -h + 3 = -x - 4. What are the prime factors of b(x)? 2, 23 Suppose -i - 3*i = -8. Suppose -50 = -3*v + i*p, 2*p = -3*v - 37 + 107. Suppose 23*y - v*y = 102. List the prime factors of y. 2, 17 Suppose -3*a = -5*o + 10, a = 2*a. Let d(v) = 0*v**3 - 14 - 7*v**o - v**3 - 3*v + 7*v + 0*v**3. What are the prime factors of d(-8)? 2, 3 Let d = -21 - -17. Let b be (-8 - -22)/(d/(-2)). Suppose 0 = b*t - 218 + 64. List the prime factors of t. 2, 11 Let w(x) = -4*x + 228. What are the prime factors of w(9)? 2, 3 List the prime factors of -1*9 - (76 + -791). 2, 353 Suppose 3*y + 371 = z, -4*z + 155 + 109 = -2*y. List the prime factors of (-3)/(-6)*y*2/(-1). 2, 61 Suppose 5*u + 2*u = 168. Suppose 0 = -c + 22 + u. What are the prime factors of (c - (-1 + 0))*1? 47 Let j(i) = i**3 - 12*i**2 - 12*i - 10. Let b be j(13). What are the prime factors of (704/132)/((-1)/b + 1)? 2 List the prime factors of 45 + -2 + -3 - -5. 3, 5 Let a = 447 - 9. What are the prime factors of a? 2, 3, 73 Let j be (25/(-5))/(0 - 1). Suppose -j*w + 24 = -2*w. Let m = 12 - w. List the prime factors of m. 2 Let n = -10541 + 15332. What are the prime factors of n? 3, 1597 Suppose 5*a - 4426 = -0*a - k, -4*k + 889 = a. What are the prime factors of a? 3, 5, 59 Suppose 14*n - 5*n = 1872. List the prime factors of n. 2, 13 Suppose 4*l - 29 = -5*m, 4 = 4*l - 0. List the prime factors of 18/m*75/6. 3, 5 Suppose 3*l + 99 = p, 0*p + 2*l + 210 = 2*p. Suppose 0 = 6*i - 0*i - p. What are the prime factors of i? 2, 3 Let v = -1121 + 3761. What are the prime factors of v? 2, 3, 5, 11 Let a(p) be the first derivative of -p**3/3 - 21*p**2/2 - 21*p + 12. What are the prime factors of a(-14)? 7, 11 Let g = 3 + 8. Suppose g*o - 6*o - 15 = 0. List the prime factors of o. 3 Let s(o) = 48*o - 55. What are the prime factors of s(9)? 13, 29 Suppose 3248 = -9*z + 13*z + i, 4 = -i. What are the prime factors of z? 3, 271 Suppose 0 = -5*h + 2*n + 2647, 7*n + 2112 = 4*h + 11*n. List the prime factors of h. 23 Let g be (-4)/(-18) + 21/27. Let f be 1 - ((-6)/2)/g. Suppose 78 = 4*h - 3*b, 2*b = -f*h + 6*b + 80. What are the prime factors of h? 2, 3 Suppose -4*r + 5 = -11. Suppose 0 = 3*s - 2*z - 238, 0*s + 5*z - 348 = -r*s. Let j = s + -23. What are the prime factors of j? 59 Suppose -4*j = 12, c - 4*c + 5*j + 795 = 0. Suppose -5*x + c = 4*u - x, -2*u - 3*x = -135. List the prime factors of u. 2, 3, 5 Let s = 0 - -4. Suppose -s*z + 372 = -i, -3*z - 2*i + 279 = -i. What are the prime factors of z? 3, 31 Let p = -727 + 1499. List the prime factors of p. 2, 193 Let b(u) = -7*u - 10. Let a(z) = -z**3 - 7*z**2 + 11*z + 16. Let n be a(-8). What are the prime factors of b(n)? 2, 23 Suppose -a = -4*k - 5*a + 32, -2*k + 4*a = 14. Suppose r + 3*r - 369 = -5*q, -87 = -r - k*q. What are the prime factors of r? 2, 3 What are the prime factors of (1 - 0) + -2319*1/(-3)? 2, 3, 43 Suppose 2576 = -39*x + 55*x. List the prime factors of x. 7, 23 Let n(h) = -h + 12. Let u be (-672)/63 - (-1)/(-3). Let s be n(u). List the prime factors of (4 - 10)/((-2)/s). 3, 23 Let q(r) = 60 + 4*r + 7*r + r**2 - 2*r**2 - 8*r. List the prime factors of q(0). 2, 3, 5 Let a(n) = n**3 - 17*n**2 + 13*n + 7. Let u be a(16). Let o = u - -52. What are the prime factors of o? 11 Let j = -23 - -26. Suppose -147 = -j*h - 0*h. List the prime factors of h. 7 Let j(n) = 8*n**2 + 7*n - 14. Let r be j(-7). Suppose 3*l - r = -5*x, l + 133 = 2*l - 3*x. What are the prime factors of l? 2, 59 Let t be (-4)/(4*-2)*4. Suppose -4*j = -2 - t, 5*i + 4*j - 19 = 0. What are the prime factors of (-6 - -12)/(i - 1)? 3 Let v(n) be the third derivative of -n**6/120 + n**5/60 - n**4/8 - n**3/6 - 5*n**2. Let d = 4 - 6. What are the prime factors of v(d)? 17 Let p be 3 + -79 + 1/((-2)/(-8)). List the prime factors of 16/p + 1/((-18)/(-886)). 7 Let d be 1/(-3)*(-72)/6. Suppose 2*q + 2 = d*p, q + 6 = 5*p - 4. Suppose -2*a - 84 = -6*a + 3*k, -q*a + k + 105 = 0. What are the prime factors of a? 3, 7 Let l(v) = -5*v**3 + 15*v**2 - 8*v + 1. Let d(p) = -14*p**3 + 44*p**2 - 23*p + 3. Let g(n) = 6*d(n) - 17*l(n). List the prime factors of g(-8). 3 Let y be 1 + -3 - (-311 - (0 + 4)). Suppose -5*t = 93 - y. What are the prime factors of t? 2, 11 Let u be (2 - -4) + (5 - 3). Suppose 2*t - 6 = 4*g, -4*t = 3*g - u - 4. What are the prime factors of t? 3 Let f = -152 + 178. Let h = f + 264. List the prime factors of h. 2, 5, 29 Let j(g) = 27*g + 1. Let v be j(1). Suppose -4*o + v = 2*b, -3*o + 12 = -6*o. What are the prime factors of b? 2, 11 Let m(u) be the first derivative of u**2 + 34*u + 3. List the prime factors of m(-11). 2, 3 Suppose 0 = i + 2*u - 2 - 9, -3*u = 2*i - 17. List the prime factors of ((-720)/(-28) - i) + 4/14. 5 Let z(l) = l**3 - 2*l**2 - l + 569. What are the prime factors of z(0)? 569 Let s be ((-90)/7)/(-5) - 3/(-7). Suppose -s*n + 80 = 2*n. What are the prime factors of n? 2 Let q(l) = l**2 - 1. Let f(z) = 2*z**2 + 4. Let b(w) = -f(w) + q(w). Let s be b(0). Let o = s + 13. List the prime factors of o. 2 Suppose -418 = -r + 3*y + 396, -4118 = -5*r + 3*y. What are the prime factors of r? 2, 7, 59 Let w(k) = k**2 - 10*k + 19. Let s be w(8). Suppose -2*b - s*m + 195 = 2*m, 315 = 3*b + 3*m. List the prime factors of b. 2, 5, 11 Let g(r) = r**2 - 10*r + 14. Let q be g(6). Let t be ((-12)/10)/(q/50). Suppose t*x = 55 + 137. List the prime factors of x. 2 Let w(c) = -5*c**3 + 0*c + 5*c**2 + 4*c**3 - 4*c + 2. Let r be w(4). Suppose 3*t + r*g - 30 = 0, 0 = 2*g + 2*g. List the prime factors of t. 2, 5 Let n(q) = 5*q**2 - 7*q. Let o be n(6). Suppose 4*t = -o + 330. Suppose -3*b = -b - t. List the prime factors of b. 2, 3 Suppose -5*m = -0*m + 20. What are the prime factors of (-156)/m + -1 + -1? 37 Suppose -10*d = -9*d - 1. Let u = d - -15. What are the prime factors of u? 2 Suppose 0 = -26*f + 6*f + 59700. List the prime factors of f. 3, 5, 199 Let w(l) = -25*l**2 + 2*l - 2. Let y be w(1). Let d = y - -124. What are the prime factors of d? 3, 11 Let f = -813 + 1681. List the prime factors of f. 2, 7, 31 Let c = 9894 - 5506. What are the prime factors of c? 2, 1097 Let z(r) be the third derivative of r**5/60 + 7*r**4/24 + 7*r**3/6 - 4*r**2. Let k be z(-7). Let b(v) = v**3 - 8*v**2 + 9*v + 4. List the prime factors of b(k). 2, 3 Suppose -21*p + 14*p - 1036 = 0. Let k = 258 + p. List the prime factors of k. 2, 5, 11 Let r(o) = 6*o**3 + 5*o + 9 - 4 - 8*o**3 - 3*o**2. Let m be r(-4). Suppose 5*k - m = 5*n, 0 = k + 3*n + 2*n - 37. List the prime factors of k. 17 List the prime factors of 9 + 0 - (-5160 - 8). 31, 167 Suppose -20*p + 1232 = -13*p. List the prime factors of p. 2, 11 Suppose -4*h = h - 20. Suppose 0 = h*k - 19 - 13. Let s = -3 + k. What are the prime factors of s? 5 Suppose 7*w = -0*w + 49. Let s(z) = 30*z - 26. What are the prime factors of s(w)? 2, 23 Let p be 4/14 - 390/(-7). Let a(y) = y**2 + 4*y - 3. Let f be a(1). List the prime factors of p + f*9/6. 59 Let k be 6/(((-5)/8)/(-5)). Let h = k + -13. What are the prime factors of h? 5, 7 Let a be 6*3/(-6) - -4. Let c = a - -8. Suppose -4*z - 24 = -c*z - v, z - v = 0. What are the prime factors of z? 2 Let t be (-1 - 0)/((-1)/(-9)). Let v be ((-148)/6)/(2/t). Suppose -9 = -5*c + v. What are the prime factors of c? 2, 3 What are the prime factors of 5 + -8 - -8 - -458? 463 Suppose 0 = -5*r + 10*r - 2*x - 1442, 3*r - 859 = -5*x. List the prime factors of r. 2, 3 Let x = -38 + 43. Suppose -x*c + 4*v = -8, 2*c + 5*v - 17 = 2*v. What are the prime factors of c? 2 Let j(p) = 8*p**2 + 2*p - 19. List the prime factors of j(-6). 257 Let i = -193 + 879. List the prime factors of i. 2, 7 Let j = -819 - -1177. What are the prime factors of j? 2, 179 Let t = -47 + 49. Suppose 0 = -t*x +

Q: Get all the records that are duplicates not just the list of them Mysql I can do Select FieldA,FieldB,FieldC,Count(*) from TableA Group By FieldA,FieldB having count(*)>1 Which will give me a list of all the FieldA,FieldB duplicates with a count for each. What I need is all the records in that subset. If a specific FieldA,FieldB combo has a count of 3 I need to see all 3 of those records. I've tried various joins to no avail. A: select a1.* from TableA a1 join ( Select FieldA, FieldB from TableA Group By FieldA, FieldB having count(*) > 1 ) a2 on a1.FieldA = a2.FieldA and a1.FieldB = a2.FieldB Join the same table on the result of the grouped one.

So, now that the Xoom has flopped, can we finally agree that "tablet" means "iPad"? Yeah, I don't see how the Android tablet makers are going to make money, Apple won't worry too much as people who want iPads are probably still going to buy iPads. Amazon's only liability is that their business model limits the Fire's availability & distribution.... at least until they can make their way through the tangled labyrinth of international media rights. If - or rather when - they do address that, I think they're going to commandeer the Android tablet market much in the way Samsung commandeered the Android smartphone market, if not more so. Between the Fire and W8/RT, Google-sanctioned Android on tablets may well find itself in a tough place. I do think the new line of Fires put a lot more pricing pressure on Apple than last year. The Fires are more media-centric, but Whispersync for games + parental controls + a new bundled e-mail client make them a bit more competitive with iPads. It's not the problems of printing that keeps the price high - but the publishers definitely introduce an artificial economy of scale. You really are better off with big orders, but it's almost completely artificial as a means to keep smaller publishers out. Breaking the big 3 is the key to opening up the textbook market. Which is exactly what handing students a tablet does. Now what do the publishers do? Where' their "hook"? They don't own the copyright to these things for the most part; the authors do. The authors, in the majority of cases, would have nothing much preventing them from producing an eBook edition at whatever price benefitted them. Looks like a classic "cut out the middleman" to me. And, not a few professors have always been chafing at the problems involved with getting their courses published, especially at the graduate school level. Not all of them are in it for the textbook money, to say the least. State governments at the secondary school level are going to see the advantage here, big time, as well. A lot of smaller states are chafing at the fact that places like Texas and California tend to limit what gets published. But, with no real economy of scale problem anymore, it wouldn't be all that hard to do an end-run around these problems. It wouldn't be totally easy or pretty at that level (the school would have to be willing to deal with the check-in and check-out of tablets and dealing with kids throwing them against walls -- though they have to do that with books as well). The economics of this could get very interesting. Won't happen overnight, but the leverage alone might change the way textbooks work. I foresee another little cosy empire to disrupt. The problem is cost. WHo will be buying the tablets? Do they have to buy the textbooks each year for each student? A decent textbook can last for 10 years (or longer) for many subjects. That is a nice amortization. It could end up that if the school has to provide the tablet and the license each year for the book that it might end up costing more in the long run for ebooks. Eldest wanted a Fire last year. He got a laptop instead. Now this year he's going to get a 16GB Fire HD 8.9 for Christmas. 1920*1200, HDMI out, HD Skype calls to grandma, kid friendly filtering so he can watch Prime streaming without the R rated stuff, no need to settle for the shitty Tegra 3 in the Nexus 7, $300. Yeah, I don't see how the Android tablet makers are going to make money, Apple won't worry too much as people who want iPads are probably still going to buy iPads. Amazon's only liability is that their business model limits the Fire's availability & distribution.... at least until they can make their way through the tangled labyrinth of international media rights. If - or rather when - they do address that, I think they're going to commandeer the Android tablet market much in the way Samsung commandeered the Android smartphone market, if not more so. Between the Fire and W8/RT, Google-sanctioned Android on tablets may well find itself in a tough place. I do think the new line of Fires put a lot more pricing pressure on Apple than last year. The Fires are more media-centric, but Whispersync for games + parental controls + a new bundled e-mail client make them a bit more competitive with iPads. Except Samsung could lose it overnight really. nothing really holding them there. Amazon has price as their big thing, and Amazon content. As for the professors, well, you're right, some do enjoy socking it to their students. That's really a myth. Authors get relatively little per book. The main reason why instructors push their own textbooks is because they think it's the best out there and because publishing helps with career advancement. On a $100 textbook, the author will earn about $15. With a class of 100 students, that's probably 5% or so of what they'd earn teaching the course considering buybacks and so on. You can make real money as a textbook author, but you make your money when you become the standard text and are selling to all institutions. To one class won't make much difference and certainly doesn't cover the 2-4 years of time you invested writing the book. The bigger problem is instructors that self-publish through the institution. That's quite common at for-profit institutions and many smaller schools. They'll create the course materials and then demand the students pay $100 for the photocopies after the course begins. They didn't earn enough on the course fees, so they made it all up on the material kickback. It was a big enough problem that Congress passed a law requiring education institutions that receive federal student aid to publish all course costs before student enroll. It remains a problem nevertheless. Except Samsung could lose it overnight really. nothing really holding them there. Amazon has price as their big thing, and Amazon content. Agreed. Amazon's lock-in goes much deeper. (Of course, Amazon isn't pulling in the billions that Samsung is. But I think I like their odds in the very long run better.) Eh. Apple doesn't make real money on content. Amazon can't either. Amazon is building a storefront for your lap. They want you to buy underwear with this thing, and their profit margin is on the Amazon Prime subscription you need to keep in order to make the device useful. This is the carrier model - they subsidize the hardware and you pay them $80/yr to use it. Once you're paying the $80, you might as well take advantage of the 2 day shipping and whatnot. It's an odd model, but one that Amazon can pull off to some degree. But it's going to have limited success because it only works in the US and to a limited degree in Canada and the UK. In every other market Amazon has nothing. Even if Amazon can beat Apple and Google in the US, development of the competing products will advance unhindered because overseas sales dominate. Eventually Amazon is going to fall behind. And eventually Amazon has to make money here - they can't keep dividing up their profit margins as they are. And they're starting to lose their sales tax benefits - starting in a week they need to collect CA sales tax. That will immediately make my local stores the same price or cheaper than Amazon for most things. But it's going to have limited success because it only works in the US and to a limited degree in Canada and the UK. In every other market Amazon has nothing. What makes you think you can't expand, slowly, internationally? The new Fire is being rolled out in the U.K. offering a very similar ecosystem. Quote: Even if Amazon can beat Apple and Google in the US, development of the competing products will advance unhindered because overseas sales dominate. Eventually Amazon is going to fall behind. And eventually Amazon has to make money here - they can't keep dividing up their profit margins as they are. And they're starting to lose their sales tax benefits - starting in a week they need to collect CA sales tax. That will immediately make my local stores the same price or cheaper than Amazon for most things. I strongly doubt Amazon is going to beat Apple. But they have a very good chance of being the biggest Android tablet vendor, by a long shot. Personally I prefer the smaller device, the ipad is bulky and heavy, why follow that trend? 5 inches is too big for a phone. Fixed that for ya there. Comparing a 5" phone to the ipad? Remember, for the medication to work, you need to take it every day. Please explain the difference between your objections to the iPad being too large and the objections of the people who said that 5 inches was too large for a phone. It should be enlightening. Why would I be concerned about those who think 5" is too large for a phone? My next phone will probably be a Note 2. If some people are happy settling for a 3.5" screen that you have to squint at, then good news for Apple? What makes you think you can't expand, slowly, internationally? The new Fire is being rolled out in the U.K. offering a very similar ecosystem. Their model requires getting a LOT of pieces in place. It's really damn hard. There's a reason why only Apple has been able to pull it off so far. And if they they want the meatspace sales included, they have to work out shipping on top of everything else. So far, they've only expanded into markets where they were also expanding their meatspace business. That's why I think focusing exclusively on digital when assessing Amazon is a mistake. Clearly their traditional sales model remains their core model. The Fire isn't really an iPad killer - it's a retail bankruptcy machine. It's designed to some day let you snap a photo of something you see in the park, pull it up on Amazon, read the review, click the Buy Now button, and have it the next day. No need to visit the mall. Oh, and it streams movies and stuff too. Quote: I strongly doubt Amazon is going to beat Apple. But they have a very good chance of being the biggest Android tablet vendor, by a long shot. Amazon can't win the digital war. Apple can go loss leader there if need be, and Amazon doesn't control the consumer endpoint well enough. They're more integrated than they used to be, but not nearly well enough integrated to pay off. And if they're not careful, they'll piss off their dependent partners like Google did. I'm sure Amazon makes more money through their iOS originated sales than they do through sales on their own device. They can't afford to break that. Bottom line, you need to make real money someplace. You can use that to subsidize other parts of your business, but you can't use low-margin divisions to subsidize no-margin divisions. That's basically what Amazon is doing. It's why they have a PE of 300. They're growing revenues but not profits, so I have no clue why investors keep rewarding them. There's no possibly way Amazon will ever grow profits to match that PE based on anything they're showing us now. That's why I think focusing exclusively on digital when assessing Amazon is a mistake. Clearly their traditional sales model remains their core model. The Fire isn't really an iPad killer - it's a retail bankruptcy machine. It's designed to some day let you snap a photo of something you see in the park, pull it up on Amazon, read the review, click the Buy Now button, and have it the next day. No need to visit the mall. Oh, and it streams movies and stuff too. Hmm, not sure I agree. Amazon's model is wildly different than Apple's, and no way as profitable, but if they can capture a sizable portion of media that people purchase (and keep, in media libraries) with their DRM, I think there's a real opportunity for establishing critical mindshare and lock-in, ensuring revenue and profit (low-margin, but high volume, and all locked-in). Amazon *has* to succeed in digital, because so much of the media they sell will be displaced by digital formats. Quote: I doubt it too, but it's hard to compete with loss leaders. Yeah, but Apple has supply-chain mastery and economies of scale that Amazon can't (so far) match, which makes the fight more equal. And Amazon can't compete with Apple in the software dept. The new Fires look like great media-centic tablets, but the iPad is so much more versatile. I can't imagine Fires establishing much of a foothold in education or enterprise. Quote: Bottom line, you need to make real money someplace. You can use that to subsidize other parts of your business, but you can't use low-margin divisions to subsidize no-margin divisions. That's basically what Amazon is doing. It's why they have a PE of 300. They're growing revenues but not profits, so I have no clue why investors keep rewarding them. There's no possibly way Amazon will ever grow profits to match that PE based on anything they're showing us now. Amazon's PE is just insane. I wouldn't go near their stock for that reason. It is very strange. That said, I *think* Bezos' long-term vision is genius (or crazy? ). Capturing a significant chunk of the tablet and digital media market *now* has potential to pay great dividends in the future. The Fires, while at the moment may be no-margin (or perilously close), could become low- or even medium-margin products once Amazon hones their supply chain and can establish themselves as a standard. 'dunno, I could be wrong, but I think Amazon has something good going on, strategically. The discussion lookmark and johnsonwax are having is what I find so puzzling about the Kindle strategy: the hardware is a loss leader at worst, break even at best. They can't be making a significant amount off digital content either as the lion's share of the money paid goes to content owners. So what is the goal of these devices? I don't begrudge Amazon's process, especially since it benefits the consumer with good value and low cost products. But from a business point of view I find them intensely fascinating. What makes you think you can't expand, slowly, internationally? The new Fire is being rolled out in the U.K. offering a very similar ecosystem. Their model requires getting a LOT of pieces in place. It's really damn hard. There's a reason why only Apple has been able to pull it off so far. And if they they want the meatspace sales included, they have to work out shipping on top of everything else. So far, they've only expanded into markets where they were also expanding their meatspace business. That's why I think focusing exclusively on digital when assessing Amazon is a mistake. Clearly their traditional sales model remains their core model. The Fire isn't really an iPad killer - it's a retail bankruptcy machine. It's designed to some day let you snap a photo of something you see in the park, pull it up on Amazon, read the review, click the Buy Now button, and have it the next day. No need to visit the mall. Oh, and it streams movies and stuff too. Quote: I strongly doubt Amazon is going to beat Apple. But they have a very good chance of being the biggest Android tablet vendor, by a long shot. Amazon can't win the digital war. Apple can go loss leader there if need be, and Amazon doesn't control the consumer endpoint well enough. They're more integrated than they used to be, but not nearly well enough integrated to pay off. And if they're not careful, they'll piss off their dependent partners like Google did. I'm sure Amazon makes more money through their iOS originated sales than they do through sales on their own device. They can't afford to break that. Bottom line, you need to make real money someplace. You can use that to subsidize other parts of your business, but you can't use low-margin divisions to subsidize no-margin divisions. That's basically what Amazon is doing. It's why they have a PE of 300. They're growing revenues but not profits, so I have no clue why investors keep rewarding them. There's no possibly way Amazon will ever grow profits to match that PE based on anything they're showing us now. New Fires (with the exception of the 8.9" model) are apparently available in the U.K, France, Germany, Spain and Italy: The discussion lookmark and johnsonwax are having is what I find so puzzling about the KindleAmazon strategy: the hardware is a loss leader at worst, break even at best. They can't be making a significant amount off digital content either as the lion's share of the money paid goes to content owners. So what is the goal of these devices? I don't begrudge Amazon's process, especially since it benefits the consumer with good value and low cost products. But from a business point of view I find them intensely fascinating. I think Bezos wants cool stuff; unlike Jobs, however, he doesn't actually care about the profit. How he managed to sneak that buy stockholders I have no clue. It's a Ponzi scheme at that point where new customers generate the profit to pay for the investment to attract them, thereby creating new network effects to attract more future customers et al. So long as the Internet grows, mail order distribution grows, and digital content grows, they are fine. As soon as the market is mature and there are two retail giants, then the game is played by profit since it will be at that point a zero-sum game. That's interesting - and a new development from Amazon. I wonder what services will be available in those countries? App stores. Amazon own Lovefilm in the UK. Kindle books. MP3s. So some of the content. Got to say as pleased as I am to see any Fire in the UK, I am itching to get a tablet, but I don't want one of the 7" models now. The 8.9" model is almost perfect. If anyone from Google is reading, please copy it and make it a Nexus. I don't really think so. Not from what I see now. I can get the Amazon app for free on my Nexus tablet. And, I wonder if 50 dollars (the difference between the new Fire and the Nexus) is going to be that compelling if the only thing Amazon is really selling is a storefront. It needs to be more. What does Amazon bring to the table as far as apps go? As far as services go? Will there be things like Google Earth? Will it get everything or even most things? How good will they be? If I want Amazon right now, on my Nexus tablet, I simply install the app and I have the store front. And, I have everything else out there without fuss. The only way Amazon really wins this game is that it gets a large stable of apps and services. In short, it has to move beyond the store front. Well past the store front. Will it really do so? I wonder if this is some of the reason behind the fact that the original Fire, by all accounts, ran out of gas. Maybe it is a seasonal thing, like other books you buy at Christmas. Or, maybe at around 200 bucks, a lot of people end up with both. My wife likes her Nook, but I ended up with a conventional Google tablet. At 200 bucks, I couldn't resist. But, the Fire, I could. Probably because it looked like just a bookstore to me. My wife already has that. Heck I have access to her bookstore on my tablet, since she's willing to share her B&N account on it. It's just not clear that I'm missing anything by not having the Nook or the Fire. I am reasonably assured at getting the whole tablet experience, whatever the heck that turns out to be. Maybe I won't turn out to be typical, but this doesn't strike me as a very geeky line of thought. The question will probably boil down to how serious Amazon gets about being more than a storefront. The discussion lookmark and johnsonwax are having is what I find so puzzling about the Kindle strategy: the hardware is a loss leader at worst, break even at best. They can't be making a significant amount off digital content either as the lion's share of the money paid goes to content owners. So what is the goal of these devices? I don't begrudge Amazon's process, especially since it benefits the consumer with good value and low cost products. But from a business point of view I find them intensely fascinating. Because not everyone cares about gouging their customers. For some a few percentage points of margin are enough. Aha: here is one catch. With the new Fires, no way to opt of Amazon's Special Offers on the lock screen. Kinda cheesy. That's rather unfortunate. I don't live in the US, so the Fires are of limited interest to me aside from on a technical level. I do, however, have a huge mancrush on the e-ink Kindles and dislike ads enough to spring for the models without ads. I can only hope that removing the option to purchase an ad-free device doesn't spread to the e-ink models. Aha: here is one catch. With the new Fires, no way to opt of Amazon's Special Offers on the lock screen. Kinda cheesy. That's rather unfortunate. I don't live in the US, so the Fires are of limited interest to me aside from on a technical level. I do, however, have a huge mancrush on the e-ink Kindles and dislike ads enough to spring for the models without ads. I can only hope that removing the option to purchase an ad-free device doesn't spread to the e-ink models. Their inclusion in the Kindle tablet devices suggests them using the revenue stream to make money over the long term. Clever idea really. They really are approaching these devices with more of a long term revenue model, womewhat similar to game consoles. Aha: here is one catch. With the new Fires, no way to opt of Amazon's Special Offers on the lock screen. Kinda cheesy. That's rather unfortunate. I don't live in the US, so the Fires are of limited interest to me aside from on a technical level. I do, however, have a huge mancrush on the e-ink Kindles and dislike ads enough to spring for the models without ads. I can only hope that removing the option to purchase an ad-free device doesn't spread to the e-ink models. Their inclusion in the Kindle tablet devices suggests them using the revenue stream to make money over the long term. Clever idea really. They really are approaching these devices with more of a long term revenue model, womewhat similar to game consoles. So ads ship enabled by default until you pay a fee to have them removed, that's interesting. Odd that they didn't just do it like the e-ink Kindles and make a SKU with no ads. Guess they're hoping many people won't opt out. The question is, will consumers sell their soul to ad campaigns for 20 to 50 bucks a device? I kind of hope this fails, because if it doesn't, then we're going to see ads on everything -- quite probably including iOS. Sooner or later, the lure of money will win. If you think Apple won't do that, well, there's this: http://arstechnica.com/staff/2012/08/op ... t-machine/ I kind of hope this fails, because if it doesn't, then we're going to see ads on everything -- quite probably including iOS. Sooner or later, the lure of money will win. If you think Apple won't do that, well, there's this: http://arstechnica.com/staff/2012/08/op ... t-machine/ Well, so far that's one new guy at Apple, so let's not blow it up into a trend until we get at least a 2nd data point even within the retail arm. I agree it's troubling, but it's waaaay too early to panic. That said, Apple's not going to put ads on iOS. They'll do ads as a way to monetize content - tv shows, music, etc. but not the devices themselves. Everything in Apple's last 15 years indicates they would profoundly oppose that. They didn't even ad ads to the iTMS back when they desperately needed the money. Yeah, I know Steve is gone, but Cook is as much at the heart of Apple's reinvention as Steve was.

Honeymoons and weddings abroad are tailor-made by Expressions Holidays. Contact us for a range of honeymoon and wedding destinations around the world and an amazing choice of honeymoons from island-hopping to visiting cultural sites. With Authentic Experiences from Expressions Holidays you enter a world of genuine holiday and travel experiences within the framework of one of our tailor-made holidays, be its significance culture, gastronomy, wine appreciation, wildlife, sports or special occasions. Expressions Spas opens a world of tailor-made spa holidays that allows you to choose according to region, type of treatment desired, product type and recommends for your party type, whether it be for couples, singles or perhaps mothers and daughters travelling together. Expressions Families affords you an amazing choice of sophisticated resorts ideally suited to families in selected destinations worldwide. You can also choose according to required facilities in resort and we suggest holidays for families with grandparents and single parent families too. Gastronomy holidays Gastronomy holidays - luxury food breaks and holidays Gastronomy conjures up images of the world’s best restaurants and master chefs; it brings to mind the flavours of delicious world cuisine and the exquisite tastes of the foods used to create them. In a world where exotic foods from around the globe can be transported to your table in a matter of hours, a holiday themed around world gastronomy is delightful concept to explore. Dine in the world’s most coveted Michelin-starred restaurants and sample the gastronomic delights of world-famous chefs and their young prodigies. Taste some of the world’s most exotic dishes and sample rare delicacies in their place of origin.Whether you want to enjoy a food and wine holiday in Italy or Spain, or to visit Sri Lanka to learn about gastronomy or the tea industry, Expressions Holidays can tailor make a gastronomy holiday to suit your culinary preferences and is guaranteed to be a wonderful experience to savour to the full.Expressions Holidays has been creating bespoke holidays and travel experiences for more than twenty years, so you can trust in us to take great care of your next holiday. Gastronomy breaks Food and wine holidays in Italy Savour the very best of Italian food, learn to cook in Italy and enjoy wine appreciation and wine tasting all

1911 North East Cork by-election The North East Cork by-election of 1911 was held on 15 July 1911. The by-election was held due to the resignation of the incumbent All-for-Ireland MP, Moreton Frewen. Frewen resigned in order for Tim Healy, who was prominent in the All-for-Ireland League but who had been lost his seat in North Louth in the previous general election, to take his seat. Healy was unopposed and held the seat. References Category:1911 in Ireland Category:1911 elections in the United Kingdom Category:By-elections to the Parliament of the United Kingdom in County Cork constituencies Category:Unopposed by-elections to the Parliament of the United Kingdom (need citation) Category:July 1911 events

694 So.2d 674 (1997) THE MISSISSIPPI BAR v. Jimmy D. McGUIRE. No. 94-BD-00520-SCT. Supreme Court of Mississippi. May 15, 1997. ORDER This matter is before the Court upon the Motion for Indefinite Suspension Pending Appeal filed by the Mississippi Bar. The complaint involves McGuire's conviction of the crime of filing a false currency reporting form in violation of 26 U.S.C.A. §§ 6050I(f)(1)(B), 7206(1). This Court entered its order on December 15, 1994, granting the Bar's request for indefinite suspension pending appeal. On January 21, 1997, the Bar provided certification that the Fifth Circuit Court of Appeals affirmed the judgment of the District Court, which affirmed McGuire's conviction, and issued the mandate on October 31, 1996. This Court finds that McGuire has been adjudicated guilty of the offense of filing false currency reporting forms, a felony, and that pursuant to Rule 6, Rules of Discipline, he should be disbarred. IT IS THEREFORE ORDERED as follows: 1. Jimmy D. McGuire be, and hereby is, DISBARRED from the practice of law. 2. This order shall constitute notice of disbarment in this cause. 3. The Clerk of the Supreme Court of Mississippi shall immediately forward an attested copy of this Order to the Circuit Court Judges and Chancellors in and for Harrison County, Mississippi, and the Senior Judges of each court shall enter this order upon the minutes of their respective courts. 4. The Clerk of the Supreme Court of Mississippi shall immediately forward an attested copy of this Order to the Clerks of the United States District Courts in and for Mississippi, to the Clerk of the United States Fifth Circuit Court of Appeals, and to the Clerk of the Supreme Court. 5. Costs of the formal complaint should be, and hereby are, assessed against Jimmy D. McGuire.

Willie Nelson Tickets Sell Out Posted: Sat 9:04 PM, Feb 07, 2004&nbsp|&nbsp Updated: Sat 9:17 PM, Feb 07, 2004 02-07-04-- Willie Nelson fans in Texoma made history in Ardmore Saturday! Many waited in line all night for the " Highway-man's" March concert and tickets sold out in just two hours, making it the first sell-out concert in Ardmore history. Fans started lining up last night and at one point, the long was so long, it actually wrapped around the building.1,900 tickets sold in the first hour alone as many people bought the limit of ten tickets at a time. Many of the fans made a $5 donation, which makes them eligible to win an autographed guitar signed by Willie.For those lucky enough to get tickets, the concert is scheduled for March 24th. Doors open at 6:30pm. Online Public Information File Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or [email protected].

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Order Michigan Supreme Court Lansing, Michigan September 30, 2013 Robert P. Young, Jr., Chief Justice 146898 Michael F. Cavanagh Stephen J. Markman Mary Beth Kelly Brian K. Zahra Bridget M. McCormack SHERELL STANLEY, Personal David F. Viviano, Representative of the ESTATE OF Justices SHERIDA STANLEY, Plaintiff-Appellee, v SC: 146898 COA: 301237 Kalamazoo CC: 2005-000601-NH KRISHNA MOHAN JAIN, M.D., Defendant-Appellant, and BORGESS MEDICAL CENTER, E. ANDERSON, C.R. BEGEMAN, T. BENSCHEL, M. GALLAGHER, A. KENDALL, SUZANNE SACKETT-MUMA, D. E. PEAKE, J. SHINABARGER, Z. SMITH, CHRIS THOMAS, and L. VROEGINDENWEY, Defendants. _____________________________________/ On order of the Court, the application for leave to appeal the February 19, 2013 judgment of the Court of Appeals is considered, and it is DENIED, because we are not persuaded that the questions presented should be reviewed by this Court. I, Larry S. Royster, Clerk of the Michigan Supreme Court, certify that the foregoing is a true and complete copy of the order entered at the direction of the Court. September 30, 2013 h0923 Clerk 

I specialise in creating unique 28 mm scale miniature armies, for Warhammer 40,000, Dust, Urban War and other science fiction games Friday, 11 October 2013 Angry Angron: Converted Daemon Prince Today's post is to showcase a commission that I have literally just finished: Angry Angron! This has been quite a lot of work, and lots of techniques went into the finished model, so I've uploaded several pictures of the finished piece. The model came to be already assembled, from a client in America, and was converted from (I think) a WFB giant, with Tyranid Hive Tyrant wings, and parts from a Chaos kit as well. The face and head were from a metal gorilla of some description - the overall model is quite heavy, but well-balanced on the base. I must say that I was impressed by the conversion work that went into this model! This shot demonstrates the work on the wings. I wanted a "bat-like" wing membrane, so used several passes of light dry brushing alongside some thinned washes. The final pass was with just a touch of varnish, enough to give the membranes a leathery finish. I added mottling and small dots to some areas of the wings to add interest. The shoulder pads were from an unknown soft plastic kit (perhaps an action figure!?!), and their positioning did conflict with the wings a little. I used Citadel metallics and washes, then highlighted up so that the gold/brass work really screams. More mottling was done on the back, around the spines and hair. This model also had a lot of skulls! This photo shows the skulls around the belt and groin. The sword was my client's idea. I envisage that maybe it was once a noble, perhaps Imperial, weapon, but has been corrupted and degraded over time. I therefore went with a high silver finish, but ran blue and green washes into the blade. This gave a nice verdigris or patina effect. I finished it with Runefang chipping. Another good view of the wings and back - the model was so big that it barely fit into my photo booth. More skulls on the spines; Angron seems to have been busy... A shot of the face - I went with simple "human" eyes, demonstrating the tragedy of this fallen primarch. Beneath all of the savagery and bloodshed, two human eyes peer from the body of a monster... This photo shows the hands - they are mechanical, and I used weathering powders and washes to demonstrate their age. Rust pigment was brushed into the joints, then sealed with pigment fixer. (Excuse the balance on this shot: the brass looks very orange, whereas in real life it is much more like aged gold.) So, that's Angron finished - hopefully my client will be pleased with him - and I move on to the next project: another squad of Blood Angels Centurions. I've actually been doing these alongside Angron, so they should be finished in the next few days...

Why bluefin tuna have warm tummies: temperature effect on trypsin and chymotrypsin. Giant bluefin tuna warm their viscera during and after a meal. The cecum of a 500-kg bluefin weighs about 9 kg and contains about 20,000 pyloric ceca, each about 10 cm long and 1.5 mm diam. Trypsin was assayed with alpha-benzoyl-DL-arginine-p-nitroanilide HCl and chymotrypsin with glutaryl-L-phenylalanine-p-nitroaniline. The effects of pH on specific activity over the range 7.5-9.5 were negligible relative to temperature effects. Specific activity and maximal reaction velocity extrapolated from a Lineweaver-Burke plot (Vmax) increased with an increase in temperature in a similar fashion (Q10 ca. 2 over temperature range of physiological significance), whereas Km was constant over the same temperature range. The advantage of the warm cecum is that protein is digested in about one-third the time, so that these tuna can process about three times as much food per day.

Šeduva Šeduva () is a city in the Radviliškis district municipality, Lithuania. It is located east of Radviliškis. Šeduva was an agricultural town dealing in cereals, flax and linseed, pigs and geese and horses, at the site of a royal estate and beside a road from Kaunas to Riga. The population from the fifteenth century was Catholic and Jewish. Until then, Lithuania had been the last pagan kingdom in Europe and allowed freedom of worship and toleration of Jews and other religions. The first Catholic shrine of Šeduva, the Church of the Invention of the Holy Cross, was built and the parish founded between 1512 and 1529. The present brick church Cross was built in Šeduva in 1643 with a donation from bishop Jurgis Tiškevičius of Vilnius. During the 18th century the bell tower was added to the structure, with further renovations and extensions in 1905. Baroque and renaissance architectural styles characterise both the exterior and interior of the church. It has a cruciform plan with an apse, low sacristy and five altars. During the 15th century the region was redefined as the Voivodeship of Trakai and Vilnius. Later it became part of the Grand Duchy of Lithuania until the Union of Lublin in 1569 created the Polish-Lithuanian Commonwealth. The Šeduva coat of arms were granted on June 25, 1654 by John II Casimir Vasa, King of Poland and Grand Duke of Lithuania and at the same time the city was granted burger rights at the request of Maria Ludvika, Queen of Poland. She descended from the Princes of Gonzaga, from Mantua in Italy. The arms of the family showed a black eagle. The small breastshield shows the French fleur-de-lis, because the Gonzaga family was related to the French Royal family. The eagle was made white in reference to the white eagle of Poland. 1792 Stanislaw II August Poniatowski, the last royal proprietor of Šeduva, concluded an agreement with the town's citizens, giving them rights to be excused from labour on the estate for a fee. In 1795, the year of a terrible fire in Šeduva, Lithuania became part of Russia when Poland was partitioned. From 1798, Baron Theodore von Ropp did not acknowledge the rights of Šeduva citizens and required of the citizens to perform labour in the town's manor. The citizens petitioned for their rights to the Russian Senate. In 1812, the Senate passed the decision to recognise the former charters of Šeduva. Between 1696 and 1762, a Jesuit mission, connected with their college at Pašiaušė, was active in the town, operating a lower school with 96 pupils up until 1828. After an insurrection in 1863 (the January Uprising), all parish schools in Šeduva were closed and replaced by public Russian language schools. In the same year a Russian Orthodox Church, designed by the architect Ustinas Golinevicius, was built and in 1866 a wooden Synagogue was added near the central market square. The Molotov-Ribbentrop Pact between Nazi Germany and Communist Russia in August 1939 and the German-Soviet Boundary and Friendship Treaty a month later placed Lithuania under Soviet control. By June 1940 the Soviets had set up a pro-Soviet government and stationed many Red Army troops in Lithuania as part of the Mutual Assistance Pact between the countries. President Antanas Smetona was forced to leave as 15 Red Army divisions came in. The pro-Soviet puppet government was controlled by Vladimir Dekanozov and Justas Paleckis, and Lithuania was made part of the Soviet Union. A Sovietisation programme began immediately. Land, banks and large businesses were nationalised. All religious, cultural, and political organizations were abolished except the Communist party. 17,000 people were deported to Siberia, where many would perish. During the years of Lithuanian anti-Soviet partisan resistance (1944–1953) in Šeduva and neighbouring districts Lithuanian Žalioji rinktinė (The Green Squad), belonging to partisans' Algimantas military district was active. Industry Šeduva is famous for sheep farming, Lithuanian Black-headed sheep are grown. The state enterprise Šeduvos avininkystė is responsible for the preservation of the genetic stock of Lithuanian Black-Headed sheep. The Holocaust in Shadeve The German army invaded Lithuania on 22 June 1941, taking Shadova - Šeduva a few days later as part of Operation Barbarossa. At first the Lithuanian population considered the Nazis to be liberators saving them from the Red Army. Five hundred years of Jewish life in Shadova - Šeduva ended in just two days of slaughter. Shadova's Jews attempted to flee east to Russia but were badly treated by Lithuanian nationalists and most returned to their homes. The German forces entered Shadova - Šeduva on 25 June 1941 and were received with flowers by many locals. By the beginning of July, Jews had to wear the yellow Star of David. Jews who had participated in the Soviet rule were immediately arrested and executed. Jews were taken to dismantle the remnants of the munitions factory in Linkaičiai, and were then accused of stealing and executed. Others were forced into labour gangs. They were set to work cleaning the streets and at the warehouses of the rail station. All the work was guarded by armed Lithuanian militi. Next all the Jews of Shadova - Šeduva had to gather in the market place with no more than a small package each, and to hand over the keys to their houses to the police. Under guard, they were escorted at night to the village of Pavartyčiai, five kilometres north-west of Shadova - Šeduva, where they were crowded into two unfinished Soviet barracks surrounded with barbed wire. The Jews were ordered to hand over all their valuables and cash. Some were shot in the next few days. On 25 August 1941 the remaining Jews of Shadova - Šeduva were loaded on trucks and taken to Liaudiškiai, ten kilometres south-west of the town where the Rollcommando Hamann of Einsatzcommando 3 and Lithuanian collaborators of the 3rd company of the Tautinio Darbo Apsaugos Batalionas were waiting for them. Over the coming two days the entire Jewish community of Shadova was shot and buried in two pre-prepared mass graves. One site was located 400 meters north of the Shadova - Šeduva road and a second 900 meters north west of the same road, close to a path in the forest. The lists of mass graves in the book The Popular Massacres of Lithuania, Part II, include the following: Liaudiskiai forest about 10 km southwest of Šeduva, one site 400 meters north of the Šeduva road and a second site 900 meters northwest of the same road, close to a path in the forest. The Jäger report concludes that Einsatzcommando 3 registered the murder in Šeduva on the 25 and 26 August 1941 of 230 Jewish men, 275 Jewish women and 159 Jewish children, a total of 664 people. References External links The murder of the Jews of Šeduva during World War II, at Yad Vashem website. Category:Cities in Lithuania Category:Cities in Šiauliai County Category:Trakai Voivodeship Category:Shavelsky Uyezd Category:Holocaust locations in Lithuania Category:Radviliškis District Municipality

import { Component, Inject, Input } from '@angular/core'; import { MediaObserver } from '@angular/flex-layout'; import { Observable } from 'rxjs'; import { map, startWith } from 'rxjs/operators'; import { API_BASE_URL } from '../../app.tokens'; import { Product } from '../../shared/services'; @Component({ selector: 'nga-product-suggestion', styleUrls: [ './product-suggestion.component.scss' ], templateUrl: './product-suggestion.component.html' }) export class ProductSuggestionComponent { @Input() products: Product[]; readonly columns$: Observable<number>; readonly breakpointsToColumnsNumber = new Map([ [ 'xs', 2 ], [ 'sm', 3 ], [ 'md', 5 ], [ 'lg', 2 ], [ 'xl', 3 ], ]); constructor( @Inject(API_BASE_URL) private readonly baseUrl: string, private readonly media: MediaObserver ) { // If the initial screen size is xs ObservableMedia doesn't emit an event // In the older versions of flex-layout we used ObservableMedia, which is deprecated. // Use MediaObserver instead this.columns$ = this.media.media$ .pipe( map(mc => <number>this.breakpointsToColumnsNumber.get(mc.mqAlias)), startWith(3) ); } urlFor(product: Product): string { return `${this.baseUrl}/${product.imageUrl}`; } }

Tuesday, May 24, 2011 I had a memory tonight, which is rather rare for me. My memories are few and far between. It was a sound that triggered the memory, one from forty years ago. The sound of a cat. It was around this same time of year, when two young boys, one that I knew personally, were playing outside. They had just learned how to tie a noose. These two boys, for whatever reason, tied nooses on opposite ends of a rope, placed them around their necks and climbed a tree. Somehow, in the process of their playing, they fell across a tree branch and the rope wasn't long enough for them to get their legs under them, to get weight off the nooses. After hearing of the tragedy, I was lying in bed, crying. This was back in the days of attic fans and open windows. Somewhere, out in the dark of night, a cat was crying out. The sound reminded me of a child, crying out for it's mother. It broke my heart, more than it was already broken. Hearing that same sound tonight, brought back the memory. The memory of two young lives, cut short. After forty years, it still brought with it, a chill. Sunday, May 22, 2011 During the recent Blog Out, it gave me a tiny bit of comfort to know I wasn't suffering alone. Not sure if anyone else in blogland has been struggling with the new Xfinity business, but I certainly have. Surprisingly, there were only minor glitches and interruptions to my cable service. Phone and internet, on the other hand, have been a real nightmare. When I think back over the years, to all the hours I've spent on the phone... hours I will never get back... talking to people whose accents I struggled to understand, it makes me want to scream. Thinking about all the money we've paid them, for all the aggravation, doesn't make me a happy camper, either. I THINK I'm up and running, again, for now. We'll see how long it lasts. Special thanks to my oldest son, for running telephone interference for me. Hearing the land line ring, music to my ears. Having my internet working, wonderful. Two Advil for the headache... PRICELESS! Just so this post isn't a total rant, I'm adding a recent picture of the ever growing, ever changing, "Chunky Monkey", fresh from a bath, smelling sweet. Friday, May 13, 2011 Monday, May 9, 2011 Much to my surprise, Mother's Day went great. Considering we thought we might have to cancel our plans, since my mother in law went to the ER on Saturday evening, we were shocked we didn't have to spend the day at the hospital. She's fine, still a little weak, but otherwise ok. She's a pretty tough ol' lady. She can still run circles around me and she's old enough to be my mother! She's a force to be reckoned with... reckon I'll pass. I've suffered plenty of her butt kicking over the past 35 years. The target may be larger, but I try to keep it covered. My sweet daughter helped me get the food in order. (Bless you!) We ate, chatted, I held the baby... lots, sat outside and sweltered, some had after dinner coffee, some had wine. The baby had liquid gold, (breast milk) which he shared with me, (reflux) several times. He's very generous that way. I tried to convince him I didn't need it, to keep it for himself. No way, he insisted on sharing. Shares with anyone close. He shared a couple of other things, too, I'll spare you the details, but... I swear I was careful and didn't pinch ANYTHING.A little later, with bellies full, my mother in law and I, opened our cards. My youngest son, the ever witty, thoughtful, ingenious person he is, handed me a book. Upon first glance, I thought for sure it was specially made. (he does things like that) It truly looks like it has tape on the front. See, doesn't that look handmade? I was so excited, UNTIL I OPENED IT! Much to my chagrin, this book is filled with pages that require the owner to basically destroy the book. The book my Son gave me, for Mother's Day. Just look at a couple of the pages... To top it off, he put a message inside... This MUST be a test! He knows how OCD/uptight/anal, I am. He expects me to cut loose and destroy this book AND give it back to him as proof I could do it! To think I gave birth to all 9 pounds, 3 ounces of him and that I could intentionally destroy something he gave me!!! I've got a newsflash for him... IT AIN'T HAPPENING, MISTER! My daughter, on the other hand, gave me a rose. It was one of her roses that adorned my header, when I first started this blog. She specifically said it's a "Sarcastic Granny" rose. Yes, it will wither and die, but it won't be because I destroyed it on purpose. Smart girl, she knows not to mess with my two remaining brain cells. She will need a sitter, at some point. Monday, May 2, 2011 ** Pat, and any other males stumbling in, you may want to leave now. ** I was a bad granny. I've been so traumatized by something that happened the day my daughter brought my new grandson home from the hospital, I've been beside myself. I may have permanent damage. My first three kids were boys. It's not like I've never been around them, or taken care of them, it's just been a REALLY LONG TIME. I do remember that changing their diapers is risky, if you aren't careful. I've been christened, more than once. My first four grandchildren are girls. That's what I've grown accustomed to. The traumatizing event happened during a diaper change. I wasn't even doing the changing, for crying out loud. Daughter and SIL were in the process and had everything laid out to do the job at hand and take care of the newly done circumcision. Prior to pulling the diaper off, they were doing the peek thing, to see what was in store. Everything looked fine and it was pretty hard to tell if the diaper was even wet. No point putting him through all that, for nothing, I decided to lend my experienced hand. Boy, did I! I reached down and squeezed the diaper, in the front, to see if it was wet and out comes the tiniest little scream, much like a newborn kitten!!! In a mere fraction of a second, I realized what I had done! I thought for sure I was going to faint, or vomit, I wasn't sure which. Forgot all about those boy bits. Remembered quickly, but not quick enough to avoid what I had already done. He must have thought Granny was trying to circumcise him again. Do you think he will remember? God, I hope not. I don't think I did any permanent damage, but if his first words sound like Mickey Mouse... I'm headin' for the hills! Followers About Me Ms. Anthropy aka Ms. A (misanthropy: n. dislike or distrust of mankind) I'm a coffee loving, brain dead wife, mother and grandmother... that stays home too much, pondering things I can't possibly fix. When my kids have a problem, I take it personally. Bringing them into this world has left me with a sense of responsibility I'm unable to ignore. Them being adults has not diminished those feelings. I am too honest, a bit sarcastic and will criticize myself more than you will be able to do. I would appreciate you not trying.

Q: Is a one-yield-per-await restricted pipe possible? I'm working with pipes-4.0.0. In that library, the number of yields to downstream a pipe makes is in general unrelated to the number of awaits from upstream. But suppose I wanted to build a restricted pipe that enforced that one and only one yield is performed for each await, while still being able to sequence these kinds of pipes using monadic (>>=). I have observed that, in the bidirectional case, each value requested from upstream by a Proxy is matched with a value sent back. So maybe what I'm searching for is a function of type Proxy a' a () b m r -> Pipe a (Either b a') m r that "reflects" the values going upstream, turning them into additional yields to downstream. Or, less generally, Client a' a -> Pipe a a'. Is such a function possible? A: You definitely do not want to use pipes for this. But, what you can do is define a restricted type that does this, do all your connections and logic within that restricted type, then promote it to a Pipe when you are done. The type in question that you want is this, which is similar to the netwire Wire: {-# LANGUAGE DeriveFunctor #-} import Control.Monad.Trans.Free -- from the 'free' package data WireF a b x = Pass (a -> (b, x)) deriving (Functor) type Wire a b = FreeT (WireF a b) That's automatically a monad and a monad transformer since it is implemented in terms of FreeT. Then you can implement this convenient operation: pass :: (Monad m) => (a -> b) -> Wire a b m () pass f = liftF $ Pass (\a -> (f a, ())) ... and assemble custom wires using monadic syntax: example :: Wire Int Int IO () example = do pass (+ 1) lift $ putStrLn "Hi!" pass (* 2) Then when you're done connecting things with this restricted Wire type you can promote it to a Pipe: promote :: (Monad m) => Wire a b m r -> Pipe a b m r promote w = do x <- lift $ runFreeT w case x of Pure r -> return r Free (Pass f) -> do a <- await let (b, w') = f a yield b promote w' Note that you can define an identity and wire and wire composition: idWire :: (Monad m) => Wire a a m r idWire = forever $ pass id (>+>) :: (Monad m) => Wire a b m r -> Wire b c m r -> Wire a c m r w1 >+> w2 = FreeT $ do x <- runFreeT w2 case x of Pure r -> return (Pure r) Free (Pass f2) -> do y <- runFreeT w1 case y of Pure r -> return (Pure r) Free (Pass f1) -> return $ Free $ Pass $ \a -> let (b, w1') = f1 a (c, w2') = f2 b in (c, w1' >+> w2') I'm pretty sure those form a Category: idWire >+> w = w w >+> idWire = w (w1 >+> w2) >+> w3 = w1 >+> (w2 >+> w3) Also, I'm pretty sure that promote obeys the following functor laws: promote idWire = cat promote (w1 >+> w2) = promote w1 >-> promote w2

The Cleveland State University wrestling team won each of the first three bouts Saturday afternoon, but visiting Binghamton stormed back to claim a 22-13 victory in the Vikings' regular-season finale inside Woodling Gymnasium. The dual began at 149 pounds, and redshirt junior Grant Turnmire got the Vikings off to a good start. Filling in for primary starter Brady Barnett, Turnmire built a 5-0 lead after two periods. His opponent broke the shutout with an escape in the third, but Turnmire would a point of riding time to claim a 6-1 victory. After a scoreless first period at 157, redshirt sophomore Nico O'Dor found himself trailing after five minutes. However, after tying the bout with an escape, he secured a takedown and held on for a two-point win. Redshirt sophomore Ryan Ford was tied, 1-1, in the third period at 165 with each wrestler having secured an escape. Like O'Dor, Ford secured the tiebreaking takedown and was able to claim a 3-2 victory. The Vikings would drop the next two bouts but still held the team score lead halfway through the dual. Junior Chris Morrow had fought valiantly against a top-10 opponent at 184 pounds, trailing by a single point late in the bout, but his opponent held off the upset bid. True freshman Ben Smith never trailed in collecting a bonus-point win at 197 pounds. He had a two-point lead after five minutes but really poured it on in the final frame. He used three takedowns and an escape in the third stanza before adding a point of riding time to claim the major decision. Junior Collin Kelly held the lead after the first period at heavyweight but was unable to hang on. Redshirt sophomore Cameron Lathem was tied, 2-2, with his foe in the third period, but this time the Bearcats got the final takedown to claim the win. After trailing by as many as seven points in his match, redshirt senior Armando Torres had cut his deficit to just three points late in the bout. In the top position, Torres was fighting to earn back points, but the period expired before he was able to do so.

). 7 Let o(g) be the third derivative of -g**4/12 + g**3/2 + 20*g**2. Suppose -b - 2*b - 2 = 5*y, y - 18 = 4*b. Determine o(y). -1 Let l(f) = -f**3 + 2*f**2 + 2*f - 3. Let j be 2/(-1)*(-3)/2. Let o be l(j). Let c(r) = -r + 4. Let m(q) = -2*q + 5. Let g(u) = o*c(u) + 5*m(u). Determine g(1). -3 Let w(r) = 6*r**2 + r - 1. Let f = -7 - -13. Let b = f - 9. Let v = -2 - b. Calculate w(v). 6 Let j = 15 + -18. Let y(x) = 2*x. Give y(j). -6 Let b(n) be the third derivative of 0*n**3 + 0 - 1/24*n**5 + 0*n + 1/12*n**4 + 1/720*n**6 + n**2. Let g(v) be the second derivative of b(v). Determine g(4). -1 Let o be 4*(-2)/(16/(-12)). Let a(s) = -s + 8. What is a(o)? 2 Let l(n) = 3*n**2 - 5 - 4*n**2 + 0*n**2 + 1 + 8*n. Give l(8). -4 Let y = 7 + -4. Let b(r) be the first derivative of -r**2 + r - 195. What is b(y)? -5 Let u(s) be the first derivative of -s**4/4 + 5*s**3/3 + 7*s - 9. Calculate u(5). 7 Let b(z) = z - 4. Let h be b(-3). Let g(r) = 2*r - 2. Calculate g(h). -16 Let l(a) = -2*a - 2. Suppose -t = -w + 1, 2*w + 30 + 3 = -5*t. Determine l(t). 8 Let v(n) = 0*n**3 - n - 3*n**3 + 2 + 4*n**3 + 0*n. Let b(w) = 1 + 3*w**3 - 6*w**3 + 3*w - 7. Let i(l) = 6*b(l) + 17*v(l). Give i(-2). 4 Let y(o) = o**2 + 7*o - 11. Let m be y(-8). Let n be 1 - (m + (4 - 0)). Let x(z) = z**3 - z**2 - 4. Calculate x(n). -4 Let a(u) be the second derivative of -2*u + 1/2*u**2 + 0 + 7/6*u**3. Give a(-1). -6 Suppose -t + 4*t - 4*g + 93 = 0, 0 = 5*g - 15. Let y = t + 28. Let o(i) = -5*i - 1. Calculate o(y). -6 Let z be (2 + -2 - 1)*2. Let l be z/(-6)*-1*3. Let w(s) = -s - 4. Let q(f) = -4*f - 11. Let j(n) = -3*q(n) + 8*w(n). What is j(l)? -3 Suppose 2*a + 12 = 4*a. Let o(y) = y**3 - 9*y**2 - y + 3. Let t(c) = -c**3 + 10*c**2 + 2*c - 4. Let u(k) = a*o(k) + 5*t(k). Determine u(3). 1 Let a = -2 + -2. Let z(k) = -k**3 - 3*k**2 + k - 4. Determine z(a). 8 Let p = 9 - 1. Let n(j) = -5 - 2 + 5 - 7*j**2 + p*j + 8. Let c(f) = f**2 - f - 1. Let y(r) = -6*c(r) - n(r). Determine y(4). 8 Let m(z) be the second derivative of z**7/840 - z**6/180 - z**5/120 + z**3/2 + 2*z. Let b(f) be the second derivative of m(f). Calculate b(-1). -2 Let w(y) = -10*y**2 - y + 1. Let x(t) = -t**3 + 17*t**2 + 17*t + 19. Let r be x(18). What is w(r)? -10 Suppose 5*n - 4 = -4*i - 12, i - 4*n - 19 = 0. Let o(y) be the second derivative of -y**4/12 + y**3/3 - 3*y**2/2 - y. What is o(i)? -6 Let w(y) = -3*y**2 + 3*y. Let n be 5/(2 + 4/8). What is w(n)? -6 Let n(q) = -26*q**3 + 9*q**2 - 7*q. Let j(c) = -13*c**3 + 4*c**2 - 3*c. Let h(f) = -5*j(f) + 2*n(f). Determine h(1). 12 Let r = -1 + 5. Let j(o) be the first derivative of -2/3*o**3 + 3*o**2 - o + 1. Calculate j(r). -9 Suppose -4*x - 3*m = -0*x - 4, 4*x - 24 = 2*m. Let w(g) = 2*g**3 - x*g**2 - g**3 - g + 0*g - 1 - 6*g. What is w(5)? -11 Let p(g) = -2*g**2 + g. Suppose 2*z + 5*a = -z - 26, 0 = 2*z - 3*a + 11. Let r(x) = x + 9. Let k be r(z). Suppose -m = -0 - k. Calculate p(m). -6 Let o(s) be the second derivative of -3/2*s**2 - 2*s - 1/3*s**3 + 0. Calculate o(-4). 5 Let c(a) = -a**3 + a**2 + 1. Let n(f) = f + 6*f - 8*f**2 - f**3 + 4*f**3 + 16 - 14. Let w(h) = 4*c(h) + n(h). Give w(-5). -4 Let o(n) = n**3 + 5*n**2 + 3*n - 2. Let s be o(-4). Let h(v) = -2*v + v**2 - 5*v - 5*v**s + 2 + 2*v**2. Calculate h(-5). -13 Suppose -2*h = 54 - 6. Let g = 22 + h. Let z(f) = -2*f**2 + f + 1. Give z(g). -9 Let p(a) = -a + 3*a - a + 4*a. What is p(-1)? -5 Let h(i) be the second derivative of 1/12*i**4 - 5/6*i**3 + 3/2*i**2 + 0 - i. Let m = -3 - -6. What is h(m)? -3 Let r = -4 - -8. Let i be (-12 + r)*(-2)/(-4). Let p(d) = d**2 + 6*d + 6. What is p(i)? -2 Suppose 4*t - 2 = 2*x, x + t = -0 - 4. Let k(j) = -j - 6. Let l(m) = -5*m - 25. Let q(w) = 9*k(w) - 2*l(w). Determine q(x). -7 Let b(j) be the second derivative of 2/3*j**3 + 1/2*j**2 + 0 + 1/12*j**4 - 3*j. What is b(-5)? 6 Let r(b) = b - 1. Suppose 3*p = -p. Calculate r(p). -1 Let d(q) = 2*q**2 - 5*q - 4. Let c be d(3). Let a(r) = 2*r - 1. What is a(c)? -3 Let m = 6 - 0. Let v(d) be the third derivative of d**5/60 - 7*d**4/24 + 7*d**3/6 - 23*d**2. What is v(m)? 1 Suppose -6*q - 4*k = -q - 26, 0 = -3*q + 2*k + 20. Let g(b) = -2*b**3 - 6*b**2 + 6*b**2 - 4 + q*b**2 + 3*b**3. Give g(-6). -4 Let x(l) be the second derivative of l**4/2 - l**2 + 6*l. Calculate x(-2). 22 Let c(f) be the third derivative of f**7/1260 - f**6/720 + f**5/15 - f**2. Let k(s) be the third derivative of c(s). Give k(1). 3 Let c(t) = t**2 - t + 1. Let b(l) = 7*l**2 - 5*l + 4. Let g(f) = -b(f) + 6*c(f). Suppose -12 = -u - 3*u. Suppose u*p + 8 = p. Calculate g(p). -10 Let s(m) = 2*m**2 + m - 1. Suppose 6 = 3*u - 0*p + 5*p, 0 = 5*u - p - 10. Calculate s(u). 9 Let w(x) = -x**3 - x**2 + x. Suppose -q - 5*n - 24 = 0, q - 6*q - 3*n = 32. Let f be (-6)/q*2 + -1. Give w(f). -10 Let t(b) be the third derivative of -b**8/2240 + b**7/2520 - b**6/720 + b**5/20 + 4*b**2. Let k(p) be the third derivative of t(p). What is k(1)? -8 Let z = 0 - -1. Let w be 0 + (28/2)/(-2). Let a(q) = 3*q**2 - 3*q + 3. Let i(g) = -2*g**2 + 2*g - 2. Let t(j) = w*i(j) - 5*a(j). Give t(z). -1 Let w(y) = -y**3 + 9*y**2 - 10*y + 10. Let h be w(8). Let c be h/(-4) + 4/8. Let t(i) = 0*i - 3*i**c + 0*i + 2 + i + i**2. Give t(2). -4 Suppose -j - k - 4 = 0, 3*j + 4*k + 16 = 6*j. Let z(n) be the third derivative of -n**5/60 + n**3 - 5*n**2. Determine z(j). 6 Let y(w) be the second derivative of 2*w + 0 + 7/6*w**3 - 1/12*w**4 - 4*w**2. What is y(6)? -2 Let h(q) = 4*q + 49. Let f be h(-12). Let p(y) = -14*y - 1. Give p(f). -15 Let f(r) be the third derivative of -r**4/8 + 2*r**3/3 - 13*r**2. Determine f(3). -5 Let q(m) be the first derivative of -1 + 1/2*m**2 + 2*m + 1/2*m**4 - 4/3*m**3. Determine q(2). 4 Let m be 6/4*(-30)/(-9). Let g(x) = x**2 + x - 6. Let c be g(m). Suppose -5*q = 25, -y = -2*y + 5*q + c. Let v(d) = d - 1. Give v(y). -2 Let d(j) be the second derivative of j**6/60 + j**5/20 + j**2 + 6*j. Let c(o) be the first derivative of d(o). Give c(-2). -4 Let h(r) be the first derivative of r**4/4 + 5*r**3/3 + 5*r**2/2 + 4*r + 3. Let o = -12 - -8. Calculate h(o). 0 Let t(x) = -x + 9. Let c be t(7). Let d(n) = 2*n**c + 1 - 3*n**2 + 6*n + 3. Suppose -3*w = -7*b + 2*b, 19 = 5*w - 2*b. What is d(w)? 9 Suppose -4*z + 10 = 2. Suppose 0 = -f + z*a - 5, f + 2*f + 4*a = 25. Let w(u) = u - 3. Determine w(f). 0 Suppose 3*n + 3 = -6. Let w be (2 - n)*-1*1. Let u(y) = 3*y + 5. Give u(w). -10 Let t = 3 + -7. Let h(i) = 4*i + 5. Let j(s) = s + 1. Let g(r) = h(r) - j(r). Calculate g(t). -8 Suppose -4*y - 20 = 0, 2*y + 17 = -5*v - 23. Let t(n) = n**3 + 6*n**2 - 3. Determine t(v). -3 Let t = 6 - -10. Suppose 0*g - t = -4*g. Let v(f) = 7*f - 2*f + g + f**2 + f. Give v(-4). -4 Let g(r) = -r**3 + 6*r**2 - 6*r + 4. Let t be g(4). Let x be (-1)/(-3)*(-1 - -10). Suppose -4*v = -4*h + 12, x*v + v = -t. Let u(s) = s + 4. Give u(h). 4 Let w(r) = 16 - 4*r**2 + 14*r**2 + 12*r + 2*r**2 + r**3. Let n be w(-11). Let c(x) = -x**2 + 6*x + 4. Calculate c(n). 9 Let y(k) = k**2 + 3*k - 3. Let r = 15 - 13. Suppose -4*n + 5*i = -9, -2*i = r*n + n + 22. Determine y(n). 1 Let m = -2 + 6. Let h(j) = j**3 - 4*j**2 - 3*j. Let v(f) = -1. Let z(p) = h(p) - 5*v(p). Give z(m). -7 Let i(o) = -o - 8. Suppose 2*m + 24 = -m. Let b = m - -2. Calculate i(b). -2 Let j(h) be the second derivative of -h**3/6 + 4*h**2 + 6*h. Calculate j(7). 1 Let a(l) be the first derivative of 1 + l - 1/2*l**2. Let p(q) = -q - 1. Let i be p(4). Give a(i). 6 Let a(t) be the third derivative of t**4/24 - t**3/3 + 21*t**2. What is a(-5)? -7 Suppose 0 = u + 4 - 2, 6 = 5*r + 2*u. Let q(v) = v**3 + v**r - 29*v + 32*v + v**2. Give q(-2). -6 Suppose 8*m - 27 = -11. Suppose 2*x = -x + 9. Let u(z) = -2 - 2*z**3 + z**3 - z + x*z**2 + 0*z**3. Calculate u(m). 0 Let b(w) = 3*w + 15. Let c(x) = x + 7. Let g(h) = -6*b(h) + 13*c(h). Determine g(-2). 11 Let x(q) be the first derivative of q**4/4 - 5*q**3/3 - 4*q**2 + 4*q - 6. Determine x(6). -8 Let u(s) = -3*s - 18. Let y(g) = -g - 6. Let w(h) = 6*u(h) - 17*y(h). Let c be w(-7). Let b(l) be the first derivative of -l**4/4 - l**3/3 + 1. Calculate b(c). -2 Let p(a) = 7*a**3 - 13*a - 7. Let j(z) = 6*z**3 + z**2 - 12*z - 7. Let w(u) = -6*j(u) + 5*p(u). Give w(-7). 7 Suppose -x = 2*g + 2*x - 2, 0 = 2*g + x + 2. Let b(o) = 4*o**2 + 3*o + 3. What is b(g)?

Further characterization of the loop structure of platelet glycoprotein IIIa: partial mapping of functionally significant glycoprotein IIIa epitopes. Glycoprotein (GP) IIb-IIIa serves as the platelet fibrinogen receptor. Studies of the tertiary structure of GPIIIa have shown that the protein has a large loop structure of at least 325 amino acids in length. To further characterize this loop structure, intact platelets were digested with alpha-chymotrypsin. Digestion products were examined using the anti-GPIIIa monoclonal antibodies (MoAbs) AP3, D3GP3, and C5GP3, as well as the human alloantibody, anti-PLA1. AP3 recognized GPIIIa digestion products of 109, 95, and 68 Kd. D3GP3 and C5GP3 recognized an additional band of 51 Kd. Time course digestions demonstrated that the 51-Kd fragment was generated by proteolysis of the 68-Kd peptide. Sequence analysis of the reduced 51-Kd peptide showed that this fragment began at amino acid 422. The nonreduced 51-Kd peptide was reactive with antibodies directed against the first 13 amino acids of GPIIIa, demonstrating the presence of a covalently attached N-terminal peptide. These data suggest that: (1) the minimum length of the loop structure is at least 384 amino acids; (2) the AP3 epitope is formed at least in part by a determinant contained within residues 348 to 421; and (3) the D3GP3 and C5GP3 epitopes are contained within amino acids 422 to 692 of GPIIIa, a region that may be flexible and involved in conformational changes that occur after ligand binding.

Q: Multithreaded filestream I'm creating a client application that connects to a server and, besides other features, logs server chat into a file, so that rule violations may be punished later. Unfortunatelly, it became necessary to have (at least) two threads in the application: receiver loop and sender loop - timing precesion is required by the server. This means, I need thread safe solution for logging data to a file. This is what may happen, if threads send log information at the (as much as possible) same time: logfile.txt: chat: Hello my name is Duke chat: Hell[WARNING]: Hacker detectedo my name is John You can see one sentence injected into another. I don't want this to ever happen. Same happens to my std::cout output, but that is not so critical. Questions: How do I make std::ofstream to only log one data at a time? (remembering other and inserting it AFTER, not in the middle) How do I check if the file was closed by other thread. (or an error) Bonus question: Could you solve same problem for std::cout? A: Standard streams have no thread safety guarantees. The only way to safely accomplish what you're trying to do is to serialize access to the stream. The easiest solution is to wrap any statement involving the stream in a mutex. { std::lock_guard<std::mutex> locked(gCoutMutex); std::cout << "This is a message" << std::endl; } A more correct approach, especially for a logger, is to have a logging thread with a message queue. When another thread wants to log, it just posts a message to the queue, and the logging thread will go through the queue and write everything to disk.

Tomato Bruschetta With Anchovies, Parmigiano Reggiano & Basil Like so much Italian food, the success of this is all about the quality of the ingredients. Don’t make this from supermarket tomatoes in June – don’t make this from supermarket tomatoes at all! The tomatoes have to be perfectly ripe and in season, and not the types that have had the character bred out of them – pick old varieties that are full of flavour Ingredients 6 slices of sourdough bread, sliced 2 cm thick on an angle 2 large garlic cloves peppery extra-virgin olive oil 3 large oxheart tomatoes (or other full-flavoured tomatoes) salt flakes and freshly ground black pepper 6 anchovies 80g parmigiano reggiano, shaved (you might not need all of this, but it is easier to shave from a larger piece) 1 handful of basil leaves Method Preheat the oven to 160°C fan-forced. Place the bread on baking trays and bake for about 25 minutes until well toasted. Rub the toasted bread all over with the garlic and drizzle with oil. Cut the tomatoes in thick slices directly on top of the toast to catch the juices. Mash and press the tomato into the toast and season with salt and pepper, then top with the anchovies, parmigiano reggiano and basil and pour over a good drizzle of oil. Serve immediately.

Q: apache rewrite rules, non-www, https I have two applications on the same server and use apache rewrite rules to redirect: www requests to non www http reuests to https Everything works ok, except one case: request www.test2.test.eu is redirect to https://www.test1.com content How can I konfigure it properly? Rewrites in domain test1.com config file: ServerName test1.com RewriteCond %{HTTP_HOST} ^www.test1.com$ [NC] RewriteRule ^(.*)$ https://www.test1.com/$1 [R=301] RewriteCond %{SERVER_PORT} !^443$ RewriteRule ^.*$ https:// %{SERVER_NAME}%{REQUEST_URI} Rewrites in domain test2.test.eu config file: ServerName test2.test.eu RewriteCond %{HTTP_HOST} ^www.test2.test.eu$ [NC] RewriteRule ^(.*)$ https://www.test2.test.eu/$1 [R=301] RewriteCond %{SERVER_PORT} !^443$ RewriteRule ^.*$ https:// %{SERVER_NAME}%{REQUEST_URI} Any suggestions very appreciated. Kind regards. A: i think your first vritualhost config is acting as the default for any request on hosts not matching 'test1.com' and 'test2.test.eu'. Try adding this ServerAlias line to see if it gets the request going to the proper config file. Rewrites in domain test2.test.eu config file: ServerName test2.test.eu ServerAlias www.test2.test.eu *.test2.test.eu RewriteCond %{HTTP_HOST} ^www.test2.test.eu$ [NC] RewriteRule ^(.*)$ https://www.test2.test.eu/$1 [R=301] RewriteCond %{SERVER_PORT} !^443$ RewriteRule ^.*$ https:// %{SERVER_NAME}%{REQUEST_URI} This explicitly tells apache that requests to 'www.test2.test.eu' should be handled by this configuration. The second entry on the ServerAlias with asterisk provides a wildcard so that even if the request comes for 'wwww.test2.test.eu' or 'xxx.test2.test.eu', the proper apache config will handle it. With using the wildcard, you could actually leave off the first entry, like this: ServerName test2.test.eu ServerAlias *.test2.test.eu RewriteCond %{HTTP_HOST} ^www.test2.test.eu$ [NC] RewriteRule ^(.*)$ https://www.test2.test.eu/$1 [R=301] RewriteCond %{SERVER_PORT} !^443$ RewriteRule ^.*$ https:// %{SERVER_NAME}%{REQUEST_URI} and it should work the same, although your first rewrite won't catch non-'www' hostnames either way.

<?xml version="1.0" encoding="utf-8"?> <RelativeLayout android:layout_width="match_parent" android:layout_height="match_parent" xmlns:android="http://schemas.android.com/apk/res/android" > <Button android:id="@+id/btn_crash_restart" android:layout_width="match_parent" android:layout_height="wrap_content" android:text="重启App" android:layout_alignParentTop="true" /> <TextView android:id="@+id/tv_crash_info" android:layout_width="match_parent" android:layout_height="wrap_content" android:singleLine="false" android:ellipsize="none" android:gravity="left" android:inputType="textMultiLine" android:layout_below="@id/btn_crash_restart" /> </RelativeLayout>

Q: Node JS Express Boilerplate and rendering I am trying out node and it's Express framework via the Express boilerplate installation. It took me a while to figure out I need Redis installed (btw, if you're making a boilerplate either include all required software with it or warn about the requirement for certain software - Redis was never mentioned as required) and to get my way around the server.js file. Right now I'm still a stranger to how I could build a site in this.. There is one problem that bugs me specifically - when I run the server.js file, it says it's all good. When I try to access it in the browser, it says 'transferring data from localhost' and never ends - it's like render doesn't finish sending and never sends the headers. No errors, no logs, no nothing - res.render('index') just hangs. The file exists, and the script finds it, but nothing ever happens. I don't have a callback in the render defined, so headers should get sent as usual. If on the other hand I replace the render command with a simple write('Hello world'); and then do a res.end();, it works like a charm. What am I doing wrong with rendering? I haven't changed a thing from the original installation btw. The file in question is index.ejs, it's in views/, and I even called app.register('.ejs', require('ejs')); just in case before the render itself. EJS is installed. Also worth noting - if I do a res.render('index'); and then res.write('Hello'); immediately afterwards, followed by res.end();, I do get "Hello" on the screen, but the render never happens - it just hangs and says "Transferring data from localhost". So the application doesn't really die or hang, it just never finishes the render. Edit: Interesting turn of events: if I define a callback in the render, the response does end. There is no more "Transferring data...", but the view is never rendered, neither is the layout. The source is completely empty upon inspection. There are no errors whatsoever, and no exceptions. A: Problem fixed. It turns our render() has to be the absolute last command in a routing chain. Putting res.write('Hello'); and res.end(); after it was exactly what broke it. I deleted everything and wrote simply res.render('index') and it worked like a charm. Learn from my fail, newbies - no outputting anything after rendering!

Chromosome 22q11.2 deletion syndrome: prenatal diagnosis, array comparative genomic hybridization characterization using uncultured amniocytes and literature review. We present prenatal diagnosis of de novo 22q11.2 microdeletion syndrome using uncultured amniocytes in a pregnancy with conotruncal heart malformations in the fetus. We discuss the genotype-phenotype correlation and the consequence of haploinsufficiency of TBX1, COMT, UFD1L, GNB1L and MED15 in the deleted region. We review the literature of chromosomal loci and genes responsible for conotruncal heart malformations and tetralogy of Fallot.

Reductive dechlorination of BCl3 for efficient ammonia borane regeneration. This paper reports a complete ammonia borane (AB) regeneration process in which Bu3SnH was utilized as a reductant for the reductive dechlorination of BCl3, and Et2PhN was selected as a 'helper ligand' to generate Et2PhN·BH3, which gives rise to a high yield of AB by a base-exchange reaction at ambient temperature.

Attached, per your request, you will find the priorities for Mexico this year. I still need to do a valuation exercise with the help of mi amigo Jaime Steffes. Saludos, Ricardo

Q: Pseudocolumn in Spark JDBC I am using a query to fetch data from MYSQL as follows: var df = spark.read.format("jdbc") .option("url", "jdbc:mysql://10.0.0.192:3306/retail_db") .option("driver" ,"com.mysql.jdbc.Driver") .option("user", "retail_dba") .option("password", "cloudera") .option("dbtable", "orders") .option("partitionColumn", "order_id") .option("lowerBound", "1") .option("upperBound", "68883") .option("numPartitions", "4") .load() Question is, can I use a pseudo column (like ROWNUM in Oracle or RRN(employeeno) in DB2) with option where I specify the partitionColumn ? If not, can we specify a partition column which is not a primary key ? A: can I use a pseudo column (like ROWNUM in Oracle or RRN(employeeno) in DB2) TL;DR Probably no. While Spark doesn't consider constraints like PRIMARY KEY or UNIQUE there is very important requirement for partitionColumn, which is not explicitly stated in the documentation - it has to be deterministic. Each executor fetches it's own piece of data using separate transaction. If numeric column is not deterministic (stable, preserved between transactions), the state of data seen by Spark might be inconsistent and records might be duplicated or skipped. Because ROWNUM implementations are usually volatile (depend on non stable ordering and can be affected by features like indexing) there not safe choice for partitionColumn. For the same reason you cannot use random numbers. Also, some vendors might further limit allowed operations on pseudocolumns, making them unsuitable for usage as a partitioning column. For example Oracle ROWNUM Conditions testing for ROWNUM values greater than a positive integer are always false. might fail silently leading to incorrect results. can we specify a partition column which is not a primary key Yes, as long it satisfies criteria described above.

we collect information about New Small Family cars from Volkswagen group - VW up, Skoda Citigo and Seat Mii Thursday, March 5, 2015 VW Up facelift - when? Up seems to be forgotten model in VW structure. Hey VW we want see new facelift at least. It is 4 years from the Up! world premiere. And readers share your expectations in comments and put your guesses when new up's facelift will come.

Pages Wednesday, September 9, 2009 The Evolution of Home Sewing: 1958 and Today Did you know that the Time Magazine online archives go back to 1923? I sure didn't, so I was amazed and delighted to find this very informative article called "Sew & Reap" about home sewing from the November 10, 1958 issue.According to this article, home sewing was a billion dollar industry at the time. This is in 50's money! I would be very interested to compare that to the profits of today's home sewing industry, wouldn't you? The article really outlines the ways in which home sewing in 1958 was so influenced by Paris fashion: Every calculated change in Paris means more money spent [on patterns]. So fashion-bent have sewing women become that patternmakers have all but junked the simple housedress designs that used to be their bread and butter. What more and more women want is the kind of high-fashion Vogue patterns long sold by Conde Nast. The originals would cost perhaps $600, but almost any woman can copy them for the cost of a $3 pattern and $50 worth of fine fabric (Vogue patterns even supply a Paris label). That's interesting to compare to today's Vogue designer lines. I've enjoyed some of their Anna Sui offerings, but the others (Michael Kors, Donna Karan, etc.) have been a little staid for my taste - certainly not the trend-driven machine that it seems to have been in 1958. What really blew my mind, though, was the fact that 20% of all women's garments in 1958 were made at home. Can you imagine? And then there was the age of the women who sewed their own clothes: One return prize for the industry is more and more younger sewers: the average home sewer's age has dropped from 45 in 1928 to 27 now, and by 1960 millions of teenagers will be sewing. A common but fashionable wedding present for suburban brides: a sewing machine. These 27-year-old women of 1958 would be 78 today. Are they still sewing, do you think? I tried in vain to find the average age of the home sewer today to compare to the stats of 1958. Though there has been an indisputable rise in young women sewing today, I would guess that the average person purchasing sewing supplies is of the boomer generation (the teenagers that the article predicted would be sewing in the 60's, I suppose!). But there was such an incredible drop in average age from 1928 to 1958 - do you think it's possible we could see the same thing happen in the coming years? One parallel I can see between the young women sewing in 1958 and young women sewing today is that is was viewed not as necessity, but as a creative outlet: Millions of women now rank sewing as their No. 1—and often only—hobby. "There's a whole new climate," says Simplicity's [director] Shapiro. "They do it as an art form." Anyway, I would love to hear your thoughts on all this. From your age perspective (whatever it may be) how do you see the future of the home sewing industry? Let's see, my mom would have been in her 20s in 1958 and was definitely sewing at least 20 percent of her clothing, if not more like 50 percent. Had she not had a stroke in recent years, she most definitely would still be sewing. I was a boomer, a preteen who learned to sew in the 60s. Still sewing, but not so much clothing these days. I do view it more as an art form now, not necessity, a hobby. My young adult daughter has little interest in sewing, unfortunately, but she likes seeing what I can make--maybe some day! I'm not sure what a boomer is, but my mum grew up in a little village in the north of Sweden in the 60's and she had to sew her own clothes if she wanted something cool. There just wasn't any retail to speak of in that part of the country back then. Not for fashionable teenagers anyways. When I grew up in the 80’s and 90’s, my mum sewed for me, too. I was never interested in learning for myself. Until a couple of years ago when a friend taught me how to sew. Now it's a hobby I share with my mum. :-) I ran the numbers through an inflation calculator, the first one a google search turns up, converting from 1958 dollars to 2008 dollars, cited in round numbers cause I already closed that browser page. The Vogue pattern: 1958, $3; 2008, $22 The fabric: 1958, $50; 2008, $350+ The designer comparison price: 1958, $600; 2008, $4000+ The pattern price is in line with the printed price for Vogue patterns today, though I can't imagine anyone paying full price for a Vogue pattern. What I find interesting about this little exercise is that a reason I usually hear cited for the decline in home sewing is the cost of fabric. But even the women I see who buy expensive fabric don't spend this much, as far as I can see. Let's say the average fancy dress requires five yard of fabric for a full skirt and a yard of fabric for a bodice. That's 6 yards of fashion fabric. Double it for lining to get twelve yards. That would be nearly $30 a yard, on average, for that fabric. While I have seen sewing bloggers who do spend that kind of money per yard, my sense is that is limited to clothing that requires much less total yardage to constuct. How many yards of fabric did your red sheath dress take, Gertie? Five total, with lining?. If you spent $30 a yard average on that fabric it would have cost you $150. I don't know about most of you, but I would find material that cost me half of that or less. I'm currently making a Victorian ball gown that I will wear at least four times a year for a few years. I will have spent just over $75 when I'm finished. That's for more than 10 yards of fabric. No, I don't think women quit sewing due to the oft-cited notion that fabric got expensive. I'm 25 and have been sewing for about 3 years. I have several friends who do so as well, but the "hobby" really came out of a desire to make cute things for our baby girls. I am however the only one I know of that is pursuing sewing as a professional career. I am a dressmaker's apprentice currently with some of my own work (which seems to be quickly building). It seems a not so lost art anymore though. Just wanted to throw in a comment on the "fabric got expensive" argument aurelia.donka mentioned... Fabric may not be any more expensive than in the 50s, but clothes can be bought REALLY cheap these days. Fast fashion is the thing now, and women are used to inexpensive, almost disposable clothing. You could probably buy multiple dresses from H&M for the cost of making a nice one yourself. I doubt that was true in 1958, no? My great grandmother and grandmother used to sew and knit. They used to make all their own clothes and the clothes for their husbands and kids. My mother was not interested in sewing. She was more interested in pottery and painting. So my great grandmother and grandmother passed the craft on to me. For the longest time I wanted to become a fashion designer. Due to family pressure, that flew out the window and in turn I stopped sewing. I started sewing again 5 years ago and I kick myself for ever stopping. I had forgotten how much fun it is. Being of the boomer age group (and still in my 50's) I might be able to offer some insight. I have recently gotten back into sewing quite a bit. I never didn't sew, but sometimes it was only two or three things a year. However in my teen years (late 60's/early 70's), I was the only one of my group of friends who did sew. And still am, except for those friends I've specifically met through sewing. As to those of the next generation, I haven't met any who sew. I work with a variety of 20s/30s year olds, and they can't even imagine doing this. My nieces and daughter-in-law express interest very occassionally, but have not taken action. I think sewing is a great creative outlet. I'm not sure anyone is sewing from economic necessity these days - so you are sewing because: - you don't fit into the norm as to size (height, weight, etc.)- your taste is different than the garments the racks in the store hold;- you are looking to sewing as a creative outlet (OR SOME COMBO of all three). to aurelia.donka and the fabric at $30/yard. I think that while that number is a little high, to buy the quality of fabric that could be found in the 50s you will definitely spend more (maybe not $30/yard but I've seen good quality everyday wools and silks for close to that) than they did in the 50s per yard. At least it seems that when I get vintage fabric from my Gran, the similar ones today are outrageous prices. This is a very interesting point, Gertie (beware, long, clumsy English discourse to follow...). I have no clue wether the situation has been the same in France at the time, because at this very moment, the clothing industry was very different in USA and in France (which took the ready-to-wear turn much later than USA, where big stores bought licences from Paris designers). No idea if it helps on the price question. For what I see now, there are much more young women sewing in USA than there are in France, but I really think US is faaaar more crafty than France. I (a student) personnally began to sew two years ago, my grans learned to sew at school (one didn't sew anything but cushions and curtains since, the two others don't sew at all), but my mother, who began school in 1968, did not. If it's sometimes an economical option, I learned to sew because I considered it the best way to get clothes the way I liked (no relation to the vintage question, since I heard of vintage patterns less than a year ago and also sew neon madras minikilts), and also because I liked the feeling of a slightly more ethical, durable wardrobe. So to me you're right: it has a lot more to do with creativity, but I'm also wondering if it is not, as Sarai pointed it, an reaction to consumerism; I'm far from a sewing expert but I hope I'll improve enough to move to slow fashion. As for the future of home sewing, I sincerely think it has to do with how people will react to fast fashion and related issues such as ecology and human rights but maybe that will go with a renewal of custom-made and the raise of quality second-hand or micro-enterprise, or the pleasure you may have to buy something from someone you 'know'(Colette patterns as an example are not absolutely my style, but since I read Sarai's blog, I'd love to purchase one of the next seasons); I really think it has to be seen within a larger perspective, it's not home sewing alone. Home Economics. Required girl course in junior high. I loved it, but I can imagine other people resented it.And of course we should include a discussion of minimum wage. And the near death of fabric-for-clothes stores once quilting took over. (I live in the far reaches, and the only fabric stores within 50 miles are Big Box and quilt stores. And no, I won't spend my not-enough money on something I can't touch first.) My Mum is 78, loved sewing , made all her clothes and those for my sister and me, not because she had to but because she loved it, my auntie was the same. Mum has done little sewing since the late 1970s when her daughters left home and she started working and had more fun buying clothes, she has continued to knit though,that is her other passion. My auntie, however, is in her early 80s and has continued sewing and I don't think she will stop until she becomes incapable or dies. I enjoy reading your interesting blog very much. The sheath dress looks very similar to one my mom wore in a photo dated 1960. She received a Singer sewing machine as a wedding gift from my father in 1959. I have many wonderful memories associated with that sewing machine and of my mom sewing in the 1960s when she was in her 20s and a homemaker. She quit sewing when she went to work. I am born in 1961 and have been sewing since a kid. I sew both crafts and garments. Some homedec. I sew less when I was younger because of time and money. Now that I have more of both, I sew more. I view sewing as a luxury hobby. I think it is less expensive to buy clothes than to sew them especially if you take time and effort into consideration. I have 2 teen daughters who took some sewing classes at JoAnn. The youngest show interest in elementary school but she is now "too busy" to sew. The eldest dislike sewing but love fashion design. They both love that I can shorten hems, mend tears and fix zippers for their favorite ready to wear which seems to fall apart easily. I think for teens it is more practical to buy than to sew since their size and fashion tastes change pretty fast. With the exception of special occasion eg prom gowns. No matter how much you pay for a dress, you always risk showing up at the event and finding someone in the same ready to wear dress which happened to both my daughters before. Fashion-conscious career women who wants more quality and better fit and whose clothing can be worn longer may have more reason to sew. Also people with time and money to spare eg. retirees and empty nesters in their late 40s and older which make up most of my classmates at sewing classes. I think the internet and shows like Project Runway have help alot in bringing excitement to sewing and to connect people who sews. Personally I think home sewing is here to stay, maybe not for necessity but for fun. I hope that people continue to learn to sew and pick it up like I have, but I don't know how it will synthesize with the culture of today, with people who rely on their microwave and Hamburger Helper for a 'meal'. I think the majority of people of my generation are obsessed with moving and doing things fast, so I don't know how sewing for pleasure could flourish. As Sarai mentioned - clothing can be bought so cheaply. It's crap quality, but is cheap, and it means that people can buy 'new' things more often even if they aren't getting a deal. Taking the time to make something themselves, or PAYING someone else to do it, would probably not be seen as an option. And poor poor seamstresses, people so undervalue their work and the effort it takes to make something. I think a LOT of people today probably don't sew because (as previously mentioned) clothing is so cheap. But, most cheap clothing (here in the UK, obviously I can't speak for elsewhere) is so poorly made, that I find it can actually work out cheaper to make yourself something, even if the fabric 'seems' pricey. The garment you make is likely to be twice as durable and probably better constructed.I'm a 70s baby so obviously can't comment with any degree of accuracy about 60s sewing trends but, I know my Mum (and her sister) did make their own clothes, both sewn and crocheted or knitted. My Nan sewed for a living, making men's trousers in a small factory but she still made most of her own clothes right up til she passed away. I always got the impression from my Mum that sewing amongst her generation was popular, if you wanted something nice, you made it. I do think, that it's no coincidence that a lot of the sewing community appears to be fairly eco-conscious. I myself, find it quite distateful that shops can sell a skirt for as little as £5, the economics just don't add up. Yet another engaging and thought-provoking post from you Gertie. Thank you! Like you, I would be interested in knowing what the statistics are for our time: what's the average age of sewists, what percentage are women (I would guess 99.99%, but I've been wrong before), how many sew as an art form (again, probably 99.99%, but...), etc. My mom, one of those teenagers in the 60s, has sewed since she was 8. She entered doll clothes she sewed into the local state fair, and won a prize and the age of ten. Art form for sure. But when she was older, mother of five children on a Navy income, she sewed clothes for herself, the kids, even my father. That was more out of necessity. Now she sews as a way to unwind, keep herself busy, help other people (she often donates the things she makes), and so on. I suppose that for some people their reason for sewing changes depending on their stage in life. When I was in middle school, then 'junior high' we still had Home Ec. I sort of learned to sew. We made a very unbecoming skirt that we had to wear to school. it scarred me and I didn't start sewing until a few years later when I was about 16. I am not only still sewing but making more and better clothing than ever before. I am now 59. I am thrilled to see so many young women sewing and using it as a creative outlet. Now young women can buy fashionable clothing at any price point so their reason for sewing is not going to be necessity, but enjoyment. Sewing is a deep pleasure for me as I am sure it is for most of the women sewing today. I think the critical issue is that young women from my generation on (I was born in 1959) were encouraged to liberate themselves from the domestic arts. I went to a school that taught typing, cooking and sewing and not a lot else. By contrast my own daughters attend a school where they were not taught cooking and had on semester of sewing - taught by a woman who couldn't sew properly herself. Sewing has moved from domestic necessity (my family didn't have much money and the only store bought clothes were my father's business suits and shirts) to creative outlet. I really believe in the transmission of skills from generation to generation - and the blog is now making it cool to sew again. I believe that the decline in home fashion sewing is due to the fact that sewing is not taught in school anymore. I learned to sew in school even though I had a mother and two sisters who could sew. My junior high school threw me in a sewing class(kicking and screaming by the way). I can remember Mccalls and Simiplicity patterns costing 25 - 50 cents and having a heart attach over the cost of Vogue patterns - 1.00 to 1.50. Of course it was Vogue you wanted. I remember this from the mid 60's. And of course it was always cheaper to sew then to buy ready to wear. In 1958 my mother was 5, and she knitter her first jumper when she was 7 (Her mother knitted all the decreases around the shoulders and stuff) but she sewed most of her clothes as a teenager. She told me this horrible story of embroidering a wonderful hippy patch on the back or some store bought jeans that had worn a little thin. Her coal mining father got so angry at the thought of HIS daughter wearing a PATCH on her clothes that he threw the jeans into the fire. He associated patches on clothes as being really poor. Also as a 23 year old I try to sew and knit as many of my clothes as possible. In Serbia, clothing is really, really expensive. It is cheaper to buy the material and pattern and pay someone to make you a custom made piece, since the cost of labor here is negligible. I would guess that while it's true that sewing in the US is becoming more "cool," the hobby will never come close to approaching the popularity levels of the '50s and '60s. Factors that limit its growth include: high cost of materials; lack of access to quality materials; decline in sewing literacy; lack of patience in a culture driven by instant gratification; needlessly large wardrobes (back in the day when a girl only hoped to have 5 dresses, taking the time to make one right made more sense); opportunity cost of labor (women's time in general is "worth more" than 50 years ago, when one considers that today's woman is (in economic terms) overqualified for traditional homemaking tasks; the prevalence of cheap, high quality ready made clothing (you might gripe about quality control issues, but in other parts of the world the quality of ready made is much, much lower); the growing sentiment among women over 30 that ill-fitting ready made clothing is normal and acceptable; and last but not least, the myriad socially-acceptable (and less demanding) creative outlets for women that were not available 50 years ago. I'm one of those "boomer" girls - the one that learned to sew in the 60's and at age 50 - I'm still sewing! However, there is a difference now. I remember that I could purchase fabric and patterns anywhere...Woolworths, Macys, Kmarts as well as the local fabric store which there was one in every town. I also remember that I could take a sewing class from 6th grade on. That every home had a sewing machine and some sewing supplies. That is not the case today. I have two thoughts on this...one that as we became a more consumer driven society, more women who sewed only because it was "cheaper" to do so became purchasers of cheap goods from discount chains. And two as more women gained access to more "professional" jobs some of the more "womenly" pursuits fell by the wayside. Seriously, how many women do you know that sew, cook well, garden, and/or can their food? These were all normal pursuits of the 50s woman! And sewing has become an artform - because the people left pursuing it have turned it into a love, a craft, a way of expressing themselves the same way that a painter or a sculptor does. As with all things, sewing has evolved...very few things in our society are the same as they were in the 50s! My grandmother (born in 1920) used to sew everything when she was a young woman. Back then it was a necessity, since she didn't have the money to buy clothing for her large family. Right now she is 89 and hasn't sewn in a long time. My mother (born in 1949) used to sew a lot when we were little. For herself, for us, for my father. But she doesn't anymore. She found a job when we were getting a little older and says she doesn't have the patience anymore to sew difficult garments. She does knit a bit sometimes for my daughter's dolls, or my little ones, but that is rare. I am 33 years old now. I learned how to sew when I was little, then forgot about it for years and picked it up again when I was pregnant of my first born. I love it and can't imagine that I'll ever stop loving being creative. But ofcourse, you never know. I don't sew because I have to, like my grandmother. I don't sew, because it's cheaper than buying, like my mother. I sew, because I want to. Because I like the sewing itself, because of how I feel when I sew, or knit for that matter, because it relaxes me and makes me feel grounded. And because I am starting to feel more and more that I want to surround myself with things that mean something. That were made with love, instead of in factories, without a thought. And because of that last factor I think sewing could become more popular in the future. I hear more and more people around me getting tired of all the materialism. I hear them grow tired of all the 'stuff', the 'clutter' that surrounds them. I hear people say that they, like myself, want to go back to a more 'basic' lifestyle. A slower lifestyle, a simpler lifestyle. And making your own clothing, baking your own bread, it all seems to fit in the trend I think I see. Ofcourse trends go by and are followed by other trends. And I can imagine that I come in contact mostly with people who think like I think. So maybe my idea can't be projected on a large scale. But still... I wouldn't be surprised when sewing would win in popularity the following years. I certainly do hope it will.. My goodness, I enjoyed each comment! It is like a breath of fresh air to read about people who know how to sew and love it. I was born in 1947 to parents who grew up during the depression, and who learned that saving money was a necessity. They passed it on, and I sewed a lot in high school, then majored in clothing and textiles at Texas Tech during the '60s. I learned how to sew at Tech--tailoring, flat pattern design, draping (still have the dress form from the draping class), and I wouldn't take for what I learned. I still teach some Family and Consumer Science classes at high school, and believe me I teach how to cook and sew. I believe that kids have an inner desire to create something with their own hands, and if they never pick up a needle or sauce pan again, at least they will know how. Besides, who know which kid will become a designer or interior decorator, and they will need to have the skill of sewing. I really liked what Sarai said about the "disposable wardrobe." Clothing is so cheap, and women are so busy there is no need to sew, but we all have a need to relax, and create. Pass on the skill girls, and have fun doing it. I just spent a few days in North Dakota helping my mom go through her storage room. I was horrified and amused that, while wedding dresses and a couple wool suits and amazing formals my grandma (b. 1911) sewed for my mom (b. 1945) had survived, nothing that my grandma sewed for herself had been saved! Only the scraps of some tantalizing, to-die-for fabrics had been preserved in some quilts. I thought we'd hit pay dirt when we found a zipper hanging bag that was Grandma's. Inside, lovingly preserved, alongside her treasured mink stole, were three scratchy polyester gowns. Not my taste but I figured still interesting to see her construction- but no! Turned out all three were store bought! I turned to my mom aghast, she laughed and said that I didn't understand how rare and exciting store-bought clothes were to them in "those days". Grandma didn't find any reason to save the things she made for herself, but was so proud of these dresses from a store! As others have said, a lot of their sewing was more out of need and budget than preference, although my grandmother did enjoy the creative side of it. But my mom particularly was too tall for off-the-rack, especially where they lived, an 8 hour drive from the nearest big department store. As for the next generation, my half-sister, who grew up without any sewing in the home at all, asked that my mom and I teach her kids as much as they'd sit still for, so they could at least have a little of that demystifying exposure at a young (preteen) age. We ran out of time this trip, but we'll see how it goes at Thanksgiving. I like that my sister had the idea, though. I'm more of a sporadically-enthusiastic than an accomplished sewer, but I've always known I can go back to it and have the confidence that I can learn because of the constant exposure when I was growing up-- it's just something I take for granted that I can do, even if never to the level my grandmother did. But it's just the reverse for my sister; she's always been kind of off-put and intimidated by sewing because of her lack of exposure or instruction. It feels more like a club she's excluded from. Of course she could learn if she wanted to and I'd love to teach her, but to her it feels like too big an undertaking, more like belatedly taking up a new language from scratch. But she wants her kids to have that initiation, so they know they can do it later if they ever want to. Talking to my sister made me think about how it really does make all the difference to pass on by example through generations-- pass on that initiation. I don't know about others' Home Ec clases, but the uninspiring duffel bag I made in mine would never have made me want to touch a sewing machine ever again! Also, as many things as I've learned from books, the web, and trial & error, nothing beats taking home a frustrating project to my mom and getting that hands-on help. She gets a kick out of my renewed interest in something she pretty much packed in for lack of need anymore in the 80s.

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4 Ways Authentic Leaders Use Feedback Subscribe to Email Updates “When we were a smaller organization, I had a lot more influence on the culture than I do now,” says Sean Kelly, CEO of SnackNation, a company that delivers healthy snacks to offices and homes across America. SnackNation currently has about 150 employees headquartered in Culver City, California. Sean says as the company roster has expanded, he’s had to be more intentional about scaling the culture, and that includes being more proactive about collecting team members’ feedback. “There were multiple phases where the influence of culture changed as our company grew. But we certainly felt it when we got to around 90 to 100 team members. I'd even say around the 30- or 40-person mark, our mid-level leadership influenced culture more than top leadership,” shares Sean. “As a leader, I could still help guide and shape our culture—but it was really no longer primarily under my influence.” “I’ve become more accepting of poll assessments and various surveys as the organization has grown larger; I'm not shaping the culture as much as I used to, and so it's very good for me to continually ensure that I understand what's going on, what's being said, and what's being felt.” 1. Use feedback to measure progress “Everything's relative, but as long as you're getting better, and as long as people have a reason to believe that—or that there is the chance for things to get better—the team members are going to be excited, and they are going to be engaged.” Don’t focus too much on where you are at now; instead, consider culture assessments as a barometer to examine over time. Another tip from Sean: Start by seeking to understand what motivates people and what people need to do their best work. If you don’t know the answer to those questions, then the information you’re gathering may not be as useful as it could be. 2. Use feedback to promote accountability Getting feedback from employees or using engagement surveys is also a way to ensure and promote shared accountability. “It helps to build a culture of ownership. If we ask somebody, ‘What is your plan to achieve success?’ Or, ‘What support are you seeking from us to help you achieve success?’ We are able to get answers to those questions, and then hold people accountable for growth,” explains Sean. “Often times, there are a lot of answers to these questions that indicate how someone is feeling about the organization or what they need. If we give them what they need to be successful, then we have a plan together, where as long as we're both improving, we're going to get there and we can hold all parties accountable.” 3. Use feedback to build transparency One of the best ways SnackNation is able to check the pulse of their company culture is through monthly, open Q&A sessions. These are anonymous, question-and-answer format sessions where anyone within the company can ask top leadership any question they want. In turn, leaders get vulnerable and honest in front of the entire group. “We don't know who wrote any of the questions. We also don't allow anyone else to see the questions that other people are asking beforehand. They just enter it into a shared Google Document and we answer it in front of the team,” he says. The open-ended questions uncover deep, meaningful insights around what people are thinking and feeling—and better yet, why they are feeling that way. “You can spot trends. You can also see if it's one person who's just frustrated and having a bad day, or maybe it's a disgruntled employee versus actually recognizing themes that multiple people feel,” explains Sean. While they also use regular surveys, this is just one more way leaders at SnackNation embrace transparency while equipping team members to share what’s on their mind. 4. Use feedback to celebrate shared values In this video, Mari Wenrick, Chief Champion of Culture at Value Added Packaging (VAP) explains how the company conducted a culture survey to gauge attitudes and perceptions within the company. “There were certain questions that I asked, such as, ‘What do you think about the company?’, ‘What do you think about the owners?’” Employees had the opportunity for the feedback to be anonymous. It might have taken vulnerability on leadership’s behalf to ask such questions, but the feedback resulted in a major milestone for the company in terms of its culture journey. The employee feedback was consistently articulated using the VAP language; it focused on the company values of love, family, care, and respect. “[This feedback] showed that they…really understood what we were doing and believed, and they had ownership in it, which was fantastic,” says Mari. What employees wrote in their feedback was so moving that they put the messages on display on campus, which was another way they were able to celebrate the company’s culture. The behavior of employees shifted from conscious actions to unconscious, cultural norms in alignment with the company values, says Mari. The unconscious was, “This is now what I'm a part of, and this is what I believe in,” she explains. “And that, to me, was an amazing turning point because it showed that they bought into what we were doing and really had ownership in it.” Work On the Next Best Version of Your Business The Course for Presidents®sets you on the pathway to the next best version of your business. You’ll join forces with your Aileron partners and get an introduction to the Professional Management System. Through two days of interactive learning with peers and six sessions one-on-one with aBusiness Advisor, you’ll develop your to-do list for where you want your business to be. This is where you take possible and make it certain. Related posts “When we were a smaller organization, I had a lot more influence on the culture than I do now,” says Sean Kelly, CEO of SnackNation, a company that delivers healthy snacks to offices and homes across America. SnackNation currently has about 150... Read More “When we were a smaller organization, I had a lot more influence on the culture than I do now,” says Sean Kelly, CEO of SnackNation, a company that delivers healthy snacks to offices and homes across America. SnackNation currently has about 150... Read More “When we were a smaller organization, I had a lot more influence on the culture than I do now,” says Sean Kelly, CEO of SnackNation, a company that delivers healthy snacks to offices and homes across America. SnackNation currently has about 150... Read More

Q: How can I find out which apps I have already downloaded on my iPhone? When you attempt to download an app that costs money, you will not be charged if you already bought the app. After you press buy and enter your iTunes password, it will say "You have already purchased this item. To download it again for free, select OK." The problem is that I deleted hundreds of apps from my phone, some of which were paid for. Later on I might find an app I like but notice that it costs money. It might be an app I had already paid for, or an app which I got when it was free. How can I know if I tap the buy button if I will be charged for the app or not? In other words, how can I know if I owned a previous version of an app before? A: To see a listing of all the apps you have purchased or downloaded, do this : Go to Store > View My Account Login Click on "Purchase History" You should now see all the apps you have downloaded before. Stolen from caliban's answer here. A: Update: The easiest way to do this is to open up the App Store on the iPad, and search for the app. If you see it say "INSTALL," rather than showing a price, it means that you have purchased the app before, and can download it again for free. One way to do this is to archive all your iTunes receipt notifications in your email account. This way you can search your email account for the application's name and see if it exists in any of your receipts. The downside to this is that if the application's name changed it won't find it since your receipt will contain the application's old name. You could try searching for the seller's name, but that might change as well. Another way to do this is to look at your iTunes purchase history. While this will have the application's current name (unlike in email archiving), there is no easy way to search through it. Another difference between the two methods is that the Purchase History will contain app updates you downloaded, while the receipt emails will not. Update: It seems that as of May, I no longer get receipts for free items via email. A: Apps that you delete on your iPhone are still in your iTunes. You should see there wich Apps you already payed for.

PaperThin Named to Deloitte's New England Fast 50 PaperThin, a mid-market Web Content Management (CMS) vendor, recently announced that they have been named to Deloitte's prestigious Technology Fast 50 Program for New England. The Fast 50 is a ranking of the 50 fastest growing technology companies in the area by Deloitte & Touche LLP, one of the nation's leading professional services firms. Program winners are ranked based on their percentage growth in fiscal year revenues over five years, from 1999 – 2003. PaperThin recently released CommonSpot 4.0, their flagship Web CMS product. "In an era where technology companies come and go, making the Deloitte Fast 50 is a testament to a company’s vision," said Stephen DiPiertro, Deloitte partner responsible for the New England Technology Fast 50 Program. PaperThin’s leadership has the right stuff for growth, and Deloitte salutes their accomplishments.” To qualify for the Technology Fast 50, companies must have had operating revenues of at least $50,000 in 1999 and $1,000,000 in 2003, must be public or private companies headquartered in North America, and be a "technology company" defined as owning proprietary technology that contributes to a significant portion of the company's operating revenues and/or devotes a significant proportion of revenues to research and development of technology. Related: PaperThin Strong in Non-Profit SectorProduct Briefing: CommonSpot 4.0 Web Content Management CMSWire is a leading, native digital publication produced by Simpler Media Group, Inc. We provide articles, research and events for sophisticated professionals driving digital customer experience strategy, evolving the digital workplace and creating intelligent information management practices. The CMSWire team produces 450+ authoritative articles per quarter for our 750,000 community members. Join us as a subscriber.

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3*o**2 - 348*o**3 + 5. -348*o**3 + o**2 + 5 Collect the terms in -845*z**3 + 9*z**2 - 9*z**2 - 687*z + 687*z. -845*z**3 Collect the terms in 1286*w**2 - 2607*w**2 + 1310*w**2. -11*w**2 Collect the terms in 132*c**2 - 24408*c**3 - 132*c**2. -24408*c**3 Collect the terms in 2*x - 284 + 76 + 78 + 92. 2*x - 38 Collect the terms in 59079*c**3 - 29552*c**3 - 29561*c**3. -34*c**3 Collect the terms in -92*h - 64*h + 14*h. -142*h Collect the terms in -867 + 28*m**3 + 867. 28*m**3 Collect the terms in -800*r + 8570 - 8570. -800*r Collect the terms in 2*l + l - 77*l**3 + 23*l**3 - 4*l + 0*l. -54*l**3 - l Collect the terms in 91*d**3 - 27*d**2 + 27*d**2 - 2*d - 74*d**3. 17*d**3 - 2*d Collect the terms in 19579782973 - 19579782973 - s**2. -s**2 Collect the terms in -33*m**2 + 64*m**2 + 9*m**2 - 13*m**2 - 24*m**2. 3*m**2 Collect the terms in -214*p + 16065 - 16065 + 207*p. -7*p Collect the terms in 32*p**3 - 10 + 24 + 70*p**3 - 14. 102*p**3 Collect the terms in 6*z**3 - 22*z**3 + 14*z**3 + 280. -2*z**3 + 280 Collect the terms in 218*p - 29*p + 71 - 104*p - 69 + 267*p. 352*p + 2 Collect the terms in -93*f + 94*f + 53 - 25. f + 28 Collect the terms in 72*m**2 + 93*m**2 - 32*m**2. 133*m**2 Collect the terms in 28*o**3 - 27*o**3 - 43*o**3. -42*o**3 Collect the terms in 369 + 368 - d - 741. -d - 4 Collect the terms in 1049*m + 263*m + 1117*m - 403*m. 2026*m Collect the terms in 15 - 42 + 11 + 16 + 232*i. 232*i Collect the terms in 313298*i - 626562*i + 313292*i. 28*i Collect the terms in -2908 + 2908 - 95*o**2. -95*o**2 Collect the terms in 1271*n**2 - 1067360*n + 1067360*n. 1271*n**2 Collect the terms in -73*o - 89*o - 71*o + 305*o - 76*o. -4*o Collect the terms in 65*f - 32*f - 2 - 9*f - 27*f. -3*f - 2 Collect the terms in -263 - 102*b**3 - 5*b + 3*b + 264. -102*b**3 - 2*b + 1 Collect the terms in 141*o**2 + 935*o - 935*o. 141*o**2 Collect the terms in 13*w**3 - 1000*w + 498*w + 502*w - 2. 13*w**3 - 2 Collect the terms in 3 - 40 + 37 - 27*i - 23*i. -50*i Collect the terms in -7408 - 207*u + 7408. -207*u Collect the terms in 457*f - 74*f**2 - 457*f. -74*f**2 Collect the terms in -49*l + 39*l**2 + 68*l**2 - 78*l**2. 29*l**2 - 49*l Collect the terms in -50*x**3 + x**2 + 7*x**3 + 42*x**3 - 7*x**2 + 6*x**2. -x**3 Collect the terms in 428 - 759*k + 759*k + 107*k**2 - 428. 107*k**2 Collect the terms in -1993814*b + 63*b**3 + 1993814*b. 63*b**3 Collect the terms in 145320*h + 145342*h - 290690*h. -28*h Collect the terms in -3*k**3 - 773*k + 440*k + 333*k. -3*k**3 Collect the terms in 822*r - 355*r - 394*r. 73*r Collect the terms in -22*y**2 - 2777201 + 2777201. -22*y**2 Collect the terms in 4950*y - 2467*y - 2483*y + 2*y**2. 2*y**2 Collect the terms in 0 + 7*m + 4 + 0*m + 13*m - 1. 20*m + 3 Collect the terms in 91 - 36*c**2 - 2 - 11. -36*c**2 + 78 Collect the terms in 8*j + 17*j**3 - j**3 + 57*j**3 + 57*j**3. 130*j**3 + 8*j Collect the terms in -9*z + 3 - 43*z + 10*z - 15*z. -57*z + 3 Collect the terms in -80 + 141 - 2*w**2 - 90. -2*w**2 - 29 Collect the terms in 421*r**3 + 5*r - 5*r - 419*r**3 - 18*r**2. 2*r**3 - 18*r**2 Collect the terms in 1088*v + 503*v - 448*v. 1143*v Collect the terms in 35*g + 4*g**2 - 131*g + 2*g**2 - 2 - 7*g**2. -g**2 - 96*g - 2 Collect the terms in 779 + 778 - 1582 - 7*z. -7*z - 25 Collect the terms in 771 + 764 + 771 - 16*j - 3077 + 771. -16*j Collect the terms in 28*q + 36*q + 36*q - 128*q + 36*q. 8*q Collect the terms in 1 - 63*l**3 + 325*l**3 - 188*l**3 - 1 - 75*l**3. -l**3 Collect the terms in -l - 5*l**2 - 439*l - 177*l - 5*l**2. -10*l**2 - 617*l Collect the terms in -92*r + 2088*r + 264*r. 2260*r Collect the terms in 123 - c**3 - 402 + 279. -c**3 Collect the terms in -75*s**3 - 11*s - 4*s**3 - 31*s**3 + 2*s + 11*s. -110*s**3 + 2*s Collect the terms in 995426*g**2 - g + g - 995231*g**2. 195*g**2 Collect the terms in 5 - 2308*j**2 + 0 - 4 + j. -2308*j**2 + j + 1 Collect the terms in 3 - 21*w - 30*w - 23*w - 24*w + 103*w. 5*w + 3 Collect the terms in -24*u + 112*u - 44*u - 10*u**2 + 0*u**2 - 46*u. -10*u**2 - 2*u Collect the terms in -1800

f := function() local l; l := 0 * [1..6]; l[[1..3]] := 1; end; f(); Where(); WhereWithVars(); quit; f:=function() if true = 1/0 then return 1; fi; return 2; end;; f(); Where(); WhereWithVars(); quit; f:=function() local x; if x then return 1; fi; return 2; end;; f(); Where(); WhereWithVars(); quit; f:=function() if 1 then return 1; fi; return 2; end;; f(); Where(); WhereWithVars(); quit; f:=function() if 1 < 0 then return 1; elif 1 then return 2; fi; return 3; end;; f(); Where(); WhereWithVars(); quit; f:=function() while 1 do return 1; od; return 2; end;; f(); Where(); WhereWithVars(); quit; f:=function() local i; for i in 1 do return 1; od; return 2; end;; f(); Where(); WhereWithVars(); quit; f:=function() local i; for i in true do return 1; od; return 2; end;; f(); Where(); WhereWithVars(); quit; f:=function(x) local i,j; for i in true do return 1; od; return 2; end;; f([1,2,3]); Where(); WhereWithVars(); quit; f:=function(x) local i,j; Unbind(x); for i in true do return 1; od; return 2; end;; f([1,2,3]); Where(); WhereWithVars(); quit; f:=function(x) local i,j; Unbind(x); j := 4; for i in true do return 1; od; return 2; end;; f([1,2,3]); Where(); WhereWithVars(); quit; f:=function() local x; repeat x:=1; until 1; return 2; end;; f(); Where(); WhereWithVars(); quit; f:=function() local x; Assert(0, 1); return 2; end;; f(); Where(); WhereWithVars(); quit; f:=function() local x; Assert(0, 1, "hello"); return 2; end;; f(); Where(); WhereWithVars(); quit; # Verify issue #2656 is fixed InstallMethod( \[\,\], [ IsMatrixObj, IsPosInt, IsPosInt ], { m, row, col } -> ELM_LIST( m, row, col ) ); l := [[1]];; f := {} -> l[2,1];; f(); Where(); WhereWithVars(); quit; # verify issue #1373 is fixed InstallMethod( Matrix, [IsFilter, IsSemiring, IsMatrixObj], {a,b,c} -> fail );

Trieste Science+Fiction 2016 Edizione 16 | 1 – 6 novembre 2016 In 1926 Hugo Gernsback founded in the United States the first magazine completely dedicated to science fiction literature, “Amazing Stories”, thus establishing the existence of a genre which the authors already knew very well but which still didn’t have a name. In 1976 the International Science Fiction Film Festival in Trieste remembered the 50th anniversary of this event with an exhibition dedicated to pulp magazines at the Castle of San Giusto. In that same year, the retrospective Fant’Italia, organized by La Cappella Underground, ventured – for the first time in a systematic manner – into the research of the Italian fantastic, among lost celluloids and repertoire films, widely anticipating the more recent secret stories of our cinema, which have caused its rediscovery and revaluation on a global scale. This is where the 16th edition of the Trieste Science+Fiction Festival starts from. In the DNA of the event there is always the good old Science Fiction Festival, but in the algorithm that animates us in the cockpit there is above all the spirit of research at 360 degrees, to bring on stage the best and the most recent independent sci-fi productions coming from all the corners of planet Earth. This is also the reason why in this 16th edition the cinéphiles will benefit of one extra day of program. But the Festival broadens its range of action especially in a multidisciplinary direction, if in the age of crossover this term can still be used. More music, with the ultra sounds “made in FVG” of the opening concert of TARM and of those by DJ Yoda during the Invasion of the Body Snatchers Night. More comics, with the o cial image signed by Davide Toffolo and the exhibition of Nathan Never in the 25th anniversary of the most popular science fiction series in Italy. More video games, with the vintage video game space Play It Again. More animation and stop motion, with two dedicated labs. More attention to the industry dimension and to training, with the first Fantastic Film Forum open to the professionals of the sector. More science, with the Futurology Meetings in collaboration with the most prestigious scientific institutions of our territory and Future Environment screenings. More attention to the younger audience, with a greater number of initiatives dedicated to schools and teenagers. More of Trieste, with Esterno/Giorno walks through the movie scene locations in town. More dramatics, with an exceptional guest star and Urania Life Achievement award who has seen things you people wouldn’t believe… It is no chance that in our vision between science and fiction there is a plus! And so, quoting a song particularly in tune with the image of this edition of the Festival: “Come one, come all. The incredible spetaculo de la vida, the incredible spetaculo de la muerte!”. And we’d like to add: “the incredible show of scientia, the incredible show of fantasia!”

Q: union all in SQL (Postgres) mess the order I have a query which is order by date , there is the query I have simplified it a bit but basically is : select * from (select start_date, to_char(end_date,'YYYY-mm-dd') as end_date from date_table order by start_date ,end_date ) where start_date is null or end_date is null It shows prefect order but I add union all select start_date, 'single missing day' as end_date from calendar_dates where db_date>'2017-12-12' and db_date<'2018-05-13' Then the whole order messed up. Why is that happened? Union or union all should just append the dataset from first query with the second, right? It should not mess the order in the first query, right? I know this query doesn't makes any sense, but I have simplified it to show the syntax. A: You can't predict what would be the order outcome by just assuming that UNION ALL will append queries in the order you write them. The query planner will execute your queries in whatever order it sees it fit. That's why you have the ORDER BY clause. Use it ! For example, if you want to force the order of the first query, then the second, do : select * from (select 1, start_date, to_char(end_date,'YYYY-mm-dd') as end_date from date_table order by start_date ,end_date ) where start_date is null or end_date is null union all select 2, start_date, 'single missing day' as end_date from calendar_dates where db_date>'2017-12-12' and db_date<'2018-05-13' ORDER BY 1

opinion The Newlyweds. Katy Perry. The Cousins. This is how my family characterized several different people we recently crossed paths with while on vacation. Here’s a brief description of each. The Newlyweds: Without going into too much graphic detail, this young couple basically couldn’t keep their hands... , 2013-03-20 11:25:42 The Newlyweds. Katy Perry. The Cousins. This is how my family characterized several different people we recently crossed paths with while on vacation. Here’s a brief description of each. Advertisement Advertisement The Newlyweds: Without going into too much graphic detail, this young couple basically couldn’t keep their hands off each other or their faces far apart. They gave the impression they were on their honeymoon. Our first impression of the Newlyweds was that they had no time for anyone but each other. Katy Perry: This beautiful young woman looks like a less voluptuous Katy Perry, the “California Gurls” and “Firework” pop singer. She’s tall, confident and willowy, with jet black hair and big, round eyes — just like Katy Perry. We noticed that Katy Perry was traveling with an older man and wondered if they were a couple (surely she was in it for the money, our devious minds figured) or a father and daughter. The Cousins: These five little boys are ages 4 and 5 with lots of energy. The Cousins appeared to be traveling with their grandparents. On the second day of our vacation, I found myself next to the Newlyweds. So I asked if that, indeed, is what they were. Turns out they are not married and were not on their honeymoon. But the man, Adam, had recently proposed to the woman, Jennifer. (She said yes!) It also turns out they were quite nice and friendly, and they did have time for and enjoyed talking to others. They even offered to lend my husband a pair of Adam’s pants for a fancy dinner if need be since my husband hadn’t packed nice pants. We crossed paths with the Newlyweds several times and always had pleasant conversations and enjoyed learning about their backgrounds. While I was trading introductions with the Newlyweds that first time, I was pleasantly surprised to look up at one point and see that Katy Perry had engaged my shy, younger daughter in conversation. Turns out she wasn’t a pop singer, but rather a Mankato State University student who was vacationing with her dad. She was fun and energetic and often took my daughters under her wing and encouraged them to participate in different activities. We learned this wasn’t the first time someone told her she looked like Katy Perry. We even had a bit of interaction with the Cousins. When asked, Grandma confirmed that the young boys were, indeed, cousins and not quintuplets. A few of them came up to me one day, somewhat shyly, and said “hi.” They actually said quite a bit more, but in a language I didn’t understand. They entertained us as they darted about and sneakily crept up to me to try to converse, and we admired the grandparents for taking the five boys on vacation. One of the most fun aspects of this vacation was the people watching we did. Even better were the people we met who became friends for the week, including the Newlyweds, Katy Perry and many others. These were people we attached a label and story to based on their looks. We were lucky enough to get to know them a bit to go beyond the label. First impressions — we learned it’s worth looking deeper and is worth the time and effort to go beyond the first impression.

Q: javafx: How to bind the Enter key to a button and fire off an event when it is clicked? Basically, I have a okayButton that sits in a stage and when it is clicked , it performs a list of tasks. Now I want to bind the Enter key to this button such that when it is clicked OR the ENTER key is pressed, it performs a list of tasks. okayButton.setOnAction(e -> { ......... } }); How can I do that ? I have read the following post already. However, it did not help me to achieve what I want to do. A: First, set a hanlder on your button : okayButton.setOnAction(e -> { ...... }); If the button has the focus, pressing Enter will automatically call this handler. Otherwise, you can do this in your start method : @Override public void start(Stage primaryStage) { // ... Node root = ...; setGlobalEventHandler(root); Scene scene = new Scene(root, 0, 0); primaryStage.setScene(scene); primaryStage.show(); } private void setGlobalEventHandler(Node root) { root.addEventHandler(KeyEvent.KEY_PRESSED, ev -> { if (ev.getCode() == KeyCode.ENTER) { okayButton.fire(); ev.consume(); } }); } If you have only one button of this kind, you can use the following method instead. okayButton.setDefaultButton(true);

Filatima asiatica Filatima asiatica is a moth of the family Gelechiidae. It is found in New Guinea, where it has been recorded from the Prince Alexander Mountains. References Category:Moths described in 1961 Category:Filatima