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, ์•”๋“ฑ๋ก ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.1971๋…„์ƒ ์—ฌ์„ฑ๋ถ„์œผ๋กœ ๊ณ ๋“ฑํ•™๊ต ์กธ์—…ํ›„ ์œ„์•”์œผ๋กœ ์œ„๋ถ€๋ถ„์ ˆ์ œ์ˆ ์„ ๋ฐ›์œผ์‹  ๊ณผ๊ฑฐ๋ ฅ ํ™•์ธ๋˜๋ฉฐ, ์ตœ๊ทผ 2023๋…„ 11์›” ๊ฑด๊ฐ•๊ฒ€์ง„ ์‹œ ๋‚ด์‹œ๊ฒฝ์—์„œ Remnanat gastric cancer ์†Œ๊ฒฌ์œผ๋กœ ๋ณธ์›์— ์ˆ˜์ˆ ์œ„ํ•ด 2024๋…„ 5์›”์— ๋‚ด์›ํ•˜์‹  ๋ถ„์ž…๋‹ˆ๋‹ค.์ด ๊ฒฝ์šฐ 1) ์œ„์•”์˜ ์ดˆ์ง„์ผ์€ ๊ณ ๋“ฑํ•™๊ต ์กธ์—…์‹œ๊ธฐ๋กœ '์ถ”์ •'ํ•˜์—ฌ ๋“ฑ๋กํ•ด์•ผํ•˜๋Š”์ง€2) ์น˜๋ฃŒ๋ฐฉ๋ฒ•๋„ ์ดˆ์ง„์ผ๋กœ๋ถ€ํ„ฐ 4๊ฐœ์›” ์ด๋‚ด์— ์ˆ˜์ˆ  ์‹œํ–‰์—ฌ๋ถ€๋ฅผ ํ™•์ธํ•  ์ˆ˜ ์—†์œผ๋‚˜ ์ˆ˜์ˆ  ์‹œํ–‰์œผ๋กœ ๋“ฑ๋กํ•ด์•ผ ํ•˜๋Š”์ง€๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
์ดˆ์ง„์ผ์„ ์•Œ ์ˆ˜ ์—†์œผ๋ฏ€๋กœ 2023.11 (๊ฑด๊ฐ•๊ฒ€์ง„์ผ)์„ ์ดˆ์ง„์ผ, ์น˜๋ฃŒ๋Š” ์ˆ˜์ˆ  ์‹œํ–‰์œผ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
์กฐ์ง๊ฒ€์‚ฌ ๊ฒฐ๊ณผ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค.Colon, transverse, endoscopic submucosal dissection (#1); Mucinous dysplasia, low grade์ด๋ ‡๊ฒŒ ๊ฒฐ๊ณผ๊ฐ€ ๋‚˜์˜จ ์ƒํ™ฉ์—์„œ ์•”๋“ฑ๋ก ๋Œ€์ƒ์ธ์ง€, ๋ชฐํฌ๋กœ์ง€๋Š” ๋ฌด์—‡์ธ์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค.
์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค.
CLL/SLL ๊ด€๋ จ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ณจ์ˆ˜๊ฒ€์‚ฌ ๊ฒฐ๊ณผ CLL ํ™•์ธ๋˜์—ˆ์œผ๋‚˜ ์ถ”ํ›„ ์ถ”๊ฐ€๋กœ ์‹œํ–‰ํ•œ ๊ฒ€์‚ฌ๊ฒฐ๊ณผ ์•„๋ž˜์™€ ๊ฐ™์ด ๋‚˜์™”์Šต๋‹ˆ๋‹ค. Mesenteric lymph nodes, right hemicolectomy: 1) B-cell lymphoma, consistent with Small lympjocytic lymphoma2) Multifocal atypical lymphoid cells infiltration of the colon and small bowel wall, suspicious for lymphoma involvement ์ด์— ๋”ฐ๋ฅธ ์ฃผ์น˜์˜์˜ ์ตœ์ข…์ง„๋‹จCLL/SLL mesenteric LNs involvement (colon & small bowel wall) +Bowel involvement of CLL (+)์œผ๋กœ ํ™•์ธ๋˜์–ด ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. M98233 ์œผ๋กœ ๋ชฐํด๋กœ์ง€ ๋ถ€์—ฌํ•˜๋Š” ๊ฒฝ์šฐ, CLL ๋˜๋Š” SLL ์— ๋”ฐ๋ผ ์›๋ฐœ๋ถ€์œ„๊ฐ€ ๋‹ฌ๋ผ์งˆ ๊ฒƒ์œผ๋กœ ์‚ฌ๋ฃŒ๋ฉ๋‹ˆ๋‹ค. ์œ„์™€ ๊ฐ™์€ ๊ฒฝ์šฐ ์›๋ฐœ๋ถ€์œ„ C421 / SEER ๋Š” 7๋กœ ๋ถ€์—ฌํ•˜๋Š”๊ฒŒ ๋งž๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๋˜ํ•œ ๋ฐœ์ƒ๊ธฐ์ „์— ๋”ฐ๋ผ ์›๋ฐœ๋ถ€์œ„ C77._ ๋กœ ๋ถ€์—ฌ๊ฐ€๋Šฅํ•œ์ง€์™€ ์›๋ฐœ๋ถ€์œ„ ๋ฆผํ”„์กฐ์ง์œผ๋กœ ๋ถ€์—ฌ๋  ๊ฒฝ์šฐ, SEER ์ฝ”๋“œ๋„ ๊ธฐ์กด ๋ฆผํ”„๋ถ€์—ฌํ•  ๋•Œ์™€ ๋™์ผํ•œ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
๋‹ค๋ฅธ ์˜์ƒ๊ฒ€์‚ฌ๊ฒฐ๊ณผ์™€ ํ•จ๊ป˜ ์›๋ฐœ๋ถ€์œ„๋ฅผ ์ฃผ์น˜์˜์—๊ฒŒ ํ™•์ธ์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค.ํ™•์ธ๋œ ์›๋ฐœ๋ถ€์œ„์— ๋งž๊ฒŒ seer๋ณ‘๊ธฐ๋ฅผ ๋“ฑ๋กํ•˜์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
๋‹ค์ค‘์›๋ฐœ์•” ๊ด€๋ จ ๋ช‡๊ฐ€์ง€ ์งˆ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค. 1. ๋™์ผ๋ถ€์œ„์— ๋™์ผ์กฐ์ง์†Œ๊ฒฌ์ผ๋•Œ๋Š” ์•”๋“ฑ๋ก์„ , ํ–‰ํƒœ์ฝ”๋“œ ๊ด€๊ณ„์—†์ด ํ•œ๋ฒˆ๋งŒ ์•”๋“ฑ๋กํ•˜๋Š”๊ฒŒ ๋งž๋‚˜์š”? 1-1) right breast : Ductal carcinoma in situ left breast : Ductal carcinoma in situ => M8500/2 ๋“ฑ๋ก 2. ์Œ์œผ๋กœ ์ด๋ฃจ์–ด์ง„ ์žฅ๊ธฐ์—์„œ ๊ฐ๊ฐ ๋™์ผ์กฐ์ง์†Œ๊ฒฌ์˜ ์ข…์–‘์ด ํ™•์ธ๋˜์—ˆ์„ ๋•Œ ํŽธ์ธก์„ฑ์€ ๋ฌด์—‡์œผ๋กœ ๋ถ„๋ฅ˜ํ•ด์•ผํ•˜๋‚˜์š”? 3. ์ด์ „ in situ๋กœ ์•”๋“ฑ๋ก๋˜์–ด์žˆ๊ณ  , ๋ช‡๋…„ ํ›„ ๋™์ผ๋ถ€์œ„์— ๋™์ผ์กฐ์ง์†Œ๊ฒฌ ์•…์„ฑ์œผ๋กœ ํ™•์ธ๋ ๋•Œ ๊ธฐ๋“ฑ๋ก๋œ ์ •๋ณด๋ฅผ ์ตœ์‹ ์ •๋ณด์— ๋งž๊ฒŒ ์—…๋ฐ์ดํŠธํ•ด์•ผ ๋ ๊นŒ์š”?
1.์งˆ๋ฌธ๋‚ด์šฉ๊ณผ ์˜ˆ์‹œ๊ฐ€ ๋งž์ง€ ์•Š์•„์„œ ์œ ์„ ๋‹ต๋ณ€ ํ•˜์˜€์Œ 2. ์›๋ฐœ์ด ์–ด๋Š์ชฝ์ธ์ง€ ํ™•์ธํ•˜๊ธฐ ์–ด๋ ค์šด๊ฒฝ์šฐ, ํŽธ์ธก์„ฑ '4'๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.3. ์•”๋“ฑ๋ก๋ณ‘์›๋งˆ๋‹ค ์ƒํ™ฉ์ด ๋‹ค๋ฅด๋ฏ€๋กœ ์œ ์„ ๋‹ต๋ณ€ ํ•˜์˜€์Œ
์ด์ „ ์งˆ์˜๋œ ๋‹ต๋ณ€์— ๋Œ€ํ•œ ์žฌ์งˆ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค 2019๋…„ urter(right)/ Non-invasive papillary urothelial carcinoma => ์•”๋“ฑ๋กํ•จ 2023๋…„ bladder/ Non-invasive papillary urothelial carcinoma, high grade ์˜ ์•”๋“ฑ๋กํ•ด์•ผ๋˜๋Š”์ง€ ์—ฌ๋ถ€์— ๋Œ€ํ•œ ๋ฌธ์˜ ๊ฒฐ๊ณผ ์•”๋“ฑ๋กํ•˜๋ผ๋Š” ๋‹ต๋ณ€์ด ์žˆ์—ˆ์Šต๋‹ˆ๋‹ค. ureter์™€ bladder๋Š” ๋™์ผ์žฅ๊ธฐ๊ตฐ์œผ๋กœ ๊ฐ„์ฃผ๋˜๋Š” ๋ถ€์œ„์ธ๋ฐ ์‹ ๊ทœ์•”๋“ฑ๋ก์„ ํ•ด์•ผ๋˜๋Š”๊ฑด๊ฐ€์š”?
๋™์ผ์žฅ๊ธฐ๊ตฐ์ด๋ฏ€๋กœ ์‹ ๊ทœ ์•”๋“ฑ๋ก์€ ํ•˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค.๊ณผ๊ฑฐ ์งˆ๋ฌธ ๋‹ต๋ณ€ ์ •์ •
ํƒ€๋ณ‘์› ์กฐ์ง๊ฒ€์‚ฌ์ƒ Metastatic epithelioid angiomyolipoma๊ฐ€ ๋‚˜์™”์Šต๋‹ˆ๋‹ค.์ €ํฌ ๋ณ‘์›์—์„œ ๊ต์ˆ˜๋‹˜๊ป˜์„œ Epithelioid AML, lt. kidney, M/lung ์ž‘์„ฑํ•ด์ฃผ์…จ์Šต๋‹ˆ๋‹ค.ํ™˜์ž Morpology๋Š” 8860/1์ด ๋งž์„๊นŒ์š”? ๊ทธ๋ ‡๋‹ค๋ฉด ์•”๋“ฑ๋ก ๋Œ€์ƒ์—์„œ ์ œ์™ธ์ผ๊นŒ์š”?
๊ต์ˆ˜๋‹˜์ด ์•…์„ฑ์œผ๋กœ ํ™•์ง„ํ•œ ๊ทผ๊ฑฐ๊ฐ€ ์—†๋‹ค๋ฉด, ์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค.
. ๊ฐ‘์ƒ์„  ํ˜•ํƒœํ•™ ์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋Š” ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค.MICRO (2 HE and 8 MG)DIAGNOSIS:Thyroid, total thyroidectomy:1. Papillary microcarcinomas (x2)1) Tumor location: left lobe2) Size of tumor: 0.2x0.2x0.2cm & 0.1x0.1x0.1cm13) Pathologic stage: pT1aNx (AJCC 2010), pT1aNx (AJCC 2017) 2. Minimally invasive follicular carcinoma (see note)1) Tumor location: isthmus2) Size of tumor: 0.8x0.7x0.5cm9) Pathologic stage: pT1aNx (AJCC 2010), pT1aNx (AJCC 2017) ์œผ๋กœ, ์˜์‚ฌ๊ฐ€ Follicular ca of thyroid [C73]์œผ๋กœ ์ง„๋‹จ๋“ฑ๋กํ•˜์…จ์Šต๋‹ˆ๋‹ค.==========================================================================8341/3 : Papillary carcinoma of thyroid(C73.9) ๊ฐ‘์ƒ์„ ์˜ ์œ ๋‘ ์•”์ข…8335/3 : Follicular carcinoma, minimally invasive(C73.9) ์ตœ์†Œ ์นจ๋ฒ” ์†Œํฌ์„ฑ ์•”์ข…M8340/3 Papillary and follicular adenocarcinoma(C73.9) ์œ ๋‘์ƒ ๋ฐ ์—ฌํฌ์ƒ ์„ ์•”์ข…2024๋…„ ๊ฐœ์ • ์ „์—๋Š” ์œ„์˜ ๋‘ ํ˜•ํƒœํ•™์„ ๊ฐ๊ฐ ๋“ฑ๋กํ•˜๋Š” ๊ฒƒ์œผ๋กœ ์•Œ๊ณ ์žˆ์œผ๋‚˜, 2024๋…„ ๊ฐœ์ • ํ›„์—๋Š” ์œ„์˜ ๋‘ ํ˜•ํƒœํ•™์ด ๋™์ผ ๋ฒ”์ฃผ๋กœ ํฌํ•จ๋˜์–ด ์•”๋“ฑ๋ก ์‹œ ์กฐํ•ฉ์ฝ”๋“œ์ธ 8340/3์œผ๋กœ ์•”๋“ฑ๋กํ•˜๋ฉด ๋˜๋Š”์ง€ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค!๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค :)
๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์— ํ•ด๋‹นํ•˜๋ฏ€๋กœ M8340/3์œผ๋กœ ํ•œ๋ฒˆ๋งŒ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.๋“ฑ๋ก์‹œ์ ์— ๋งž์ถ”์–ด ์•”๋“ฑ๋ก ๊ธฐ์ค€์„ ์ ์šฉํ•˜๋ฏ€๋กœ, ๊ฐœ์ • ํ›„ ์ง€์นจ์„ ์‚ฌ์šฉํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.
.์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ ์•„๋ž˜์™€ ๊ฐ™์€ ๊ฒฝ์šฐ Differentiated high grade thyroid carcinoma(solid/trabecular papillary thyroid carcinoma with foci of necrosis)์˜ M code ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.Thyroid, right, total unilateral thyroidectomy: Differentiated high-grade thyroid carcinoma (solid/trabecular papillary thyroid carcinoma with foci of necrosis) 1. Tumor Focality: Unifocal 2. Tumor Laterality: Right lobe 3. Tumor Size: Greatest dimension: 3.5cm 4. Pathologic Staging of Primary Tumor (pT): pT2: Tumor >2 cm, but โ‰ค4 cm in greatest dimension, limited to thyroid 5. Extrathyroidal Extension (with no clinical/macroscopic evidence of invasion) Not identified 6. Margins: Uninvolved by carcinoma 7. Angioinvasion: Not identified 8. Lymphatic invasion: Not identified 9. Perineural Invasion: Not identified 10. Additional Pathologic Findings: Not identified 11. Lymph Nodes, perithyroidal(0/1): Free of tumor in all 1 lymph node (0/1)
M8260/3(papillary thyroid carcinoma)์œผ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
[24.04.02-EGD Bx, ์™ธ๋ž˜]stomach fiberscopic biopsy : Signet ring cell carcinoma [24.04.24-subtotal gastrectomy, ์ž…์›] EARLY GASTRIC CARCINOMA 1) Preoperative treatment: not done 2) Location of tumor a) Involvement: lower third b) Center at body, lesser curvature 3) Gross type: 0-IIc 4) Histologic type by WHO: mucinous adenocarcinoma composed exclusively of signet ring cells 5) Histologic grade by WHO: not applicable 6) Histologic type by Lauren: diffuse 7) Tumor size: 4.0 x 2.8 x 0.2 cm 8) Depth of invasion: submucosa (sm2) (pT1b by AJCC 8th Ed.) a) Depth of submucosal invasion: 900 ฮผm 9) Surgical margins: free from tumor (safety margin: proximal: 2.2 cm; distal: 6.5 cm) 10) Lymph node: no metastasis in 39 regional lymph nodes (pN0) (LN #1: 0/8, LN #3: 0/3, LN #4: 0/6, LN #5: 0/3, LN #6: 0/2, LN #7: 0/3, LN #8: 0/4, LN #9: 0/2, LN #11: 0/4, LN #12: 0/1, lesser curvature: 0/3) 11) Poorly differentiated or poorly cohesive component: present (100%) 12) Lymphovascular invasion: not identified 13) Perineural invasion: not identified 14) Stromal reaction: absent 15) Preexisting adenoma: not identified 16) Associated findings: none์œ„์™€ ๊ฐ™์ด ๋‚˜์˜จ๊ฒฝ์šฐ ์ˆ˜์ˆ  ํ›„ M์ฝ”๋“œ๋ฅผ ๋ถ€์—ฌํ•˜๊ณ ์ž ํ•  ๋•Œ M8480(Mucinous adenocarcinoma) ๋กœ ๋ถ€์—ฌํ•ด์•ผํ• ์ง€M8490(Signet ring cell carcinoma)์œผ๋กœ ๋ถ€์—ฌํ•ด์•ผํ•˜๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
M8480(Mucinous adenocarcinoma)์œผ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
. Kidney M์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋Š” ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค.[์™ธ๊ณผ๋ณ‘๋ฆฌํ•™์ ๊ฒ€์‚ฌ]PATHOLOGICAL DIAGNOSIS :Kidney, right, robotic partial nephrectomy ; Oncocytic renal cell neoplasm of low malignant potential,suggestive of low-grade oncocytic tumor (See note) 1) tumor size: 2.5 x 2.4cm 2) Fuhrman nuclear grade: 2/4 3) Necrosis: absent 4) Lymphovascular invasion: absent 5) Perineural invasion: absent 6) Sarcomatoid feature: absent 7) Resection margin, renal parenchyma: free from tumor (safety margin: 0.1cm)Note: Intra and interdepartmental(Mokdong hospital) consultation was done.GROSS DESCRIPTION :The specimen consists of received in fresh is a radical nephrectomy specimen of right kidney (2.8 x 2.6 x 1.5cm, 6.9gm). On cut section, it shows a well-circumscribed, yellow-tan mass with hemorrhage (2.5 x 2.4 x 1.1cm). It is 0.1cm apart from the parenchymal resection margin. -Block code: 1-4, Representative sections are embedded-Gross photo: yes-Preservation block : 1-4๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
์•”๋“ฑ๋ก๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค.
. ๊ฐ‘์ƒ์„  ํ˜•ํƒœํ•™ ์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋Š” ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค.MICRO (6 HE)DIAGNOSIS:Thyroid, right, lobectomy:Papillary thyroid carcinomas (x3), follicular variant (x2) & conventional type (x1)1) Tumor location: right lobe2) Size of tumor: 1.3x1.0x1.0cm, 0.5x0.4x0.3cm & 0.2x0.2x0.2cm8260/3 : Papillary carcinoma of thyroid(C73.9) ๊ฐ‘์ƒ์„ ์˜ ์œ ๋‘ ์•”์ข…8340/3 : Papillary carcinoma, follicular variant(C73.9) ์†Œํฌ์„ฑ ๋ณ€์ข…์„ฑ ์œ ๋‘์ƒ ์•”์ข…2024๋…„ ๊ฐœ์ • ์ „์—๋Š” ์œ„์˜ ๋‘ ํ˜•ํƒœํ•™์„ ๊ฐ๊ฐ ๋“ฑ๋กํ•˜๋Š” ๊ฒƒ์œผ๋กœ ์•Œ๊ณ ์žˆ์œผ๋‚˜, 2024๋…„ ๊ฐœ์ • ํ›„์—๋Š” ์œ„์˜ ๋‘ ํ˜•ํƒœํ•™์ด ๋™์ผ ๋ฒ”์ฃผ๋กœ ํฌํ•จ๋˜์–ด ์•”๋“ฑ๋ก ์‹œ 8340/3์œผ๋กœ ์•”๋“ฑ๋กํ•˜๋ฉด ๋˜๋Š”์ง€ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค!๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค :)
8260/3 : Papillary carcinoma of thyroid(C73.9) ๊ฐ‘์ƒ์„ ์˜ ์œ ๋‘ ์•”์ข…(3๊ทธ๋ฃน)8340/3 : Papillary carcinoma, follicular variant(C73.9) ์†Œํฌ์„ฑ ๋ณ€์ข…์„ฑ ์œ ๋‘์ƒ ์•”์ข…(3๊ทธ๋ฃน)๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์— ํ•ด๋‹นํ•˜๋ฏ€๋กœ M8340/3์œผ๋กœ ํ•œ๋ฒˆ๋งŒ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
2023๋…„์— RLL ๋ถ€์œ„์— ํ์—ฝ ์ ˆ์ œํ•˜์…จ๋˜ ๋ถ„์œผ๋กœ ๊ทธ ๋‹น์‹œ M8072/3์œผ๋กœ ๋“ฑ๋กํ•˜์˜€์Šต๋‹ˆ๋‹ค. Lung, right superior, segmentectomy;Invasive squamous cell carcinoma, non-keratinizing, well differentiated๊ธˆ๋ฒˆ 2024๋…„์— F/Uํ•œ PET- CT์—์„œ LLL ๋ถ€์œ„์— ๊ฒฐ์ ˆ ํ™•์ธ๋˜์–ด PCNA ์‹œํ–‰ํ•˜์˜€๊ณ , ์•” ํ™•์ธ๋˜์–ด ์™ผ์ชฝ์—๋„ ์ถ”๊ฐ€์ ์œผ๋กœ ํ์—ฝ ์ ˆ์ œ๋ฅผ ์‹œํ–‰ํ•˜์˜€์Šต๋‹ˆ๋‹ค.Lung, left, superior, segmentectomy;Combined large cell neuroendocrine carcinoma and squamous cell carcinoma, non-keratinizing, moderately differentiated์ž„์ƒ์ ์œผ๋กœ๋Š” Cell type ๋‹ค๋ฅธ ์ƒํƒœ๋กœ Double primary Lung Cancer ์œผ๋กœ ๋ณด๊ณ  ๊ณ„์‹œ๋‚˜, ๋™์ผ์žฅ๊ธฐ๊ตฐ(C34)์—์„œ ๊ธˆ๋ฒˆ ์™ผ์ชฝ์—์„œ ํ™•์ธ๋œ ํ˜•ํƒœํ•™์  ์ฝ”๋“œ๋Š” M8013/3 (๊ทธ๋ฃน 5, unspecified)์— ํ•ด๋‹นํ•˜๋ฏ€๋กœ ๊ธฐ์กด์— ์•”๋“ฑ๋ก๋˜์–ด ์žˆ๋˜ M8072/3 (๊ทธ๋ฃน 1)๋งŒ ์œ ์ง€ํ•˜๋ฉด ๋˜๋Š”์ง€ ํ™•์ธ์ฐจ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
๋„ค, ๋งž์Šต๋‹ˆ๋‹ค. ์ตœ์ดˆ ์•”๋“ฑ๋กํ•œ ๋‚ด์šฉ์„ ์œ ์ง€ํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.
์•”๋“ฑ๋ก ๋Œ€์ƒ ์—ฌ๋ถ€์ธ์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค.์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ:Colon, "mid A", EMR: Tubular adenoma with high grade dysplasia * Resected margin involvement: absentM์ฝ”๋“œ์™€ ์•”๋“ฑ๋ก ๋Œ€์ƒ ์—ฌ๋ถ€๊ฐ€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค ใ… ใ… 
High grade dysplasia๋ฅผ /2๋กœ ์ธ์ •ํ•˜๋Š” ๋ถ€์œ„์— ํ•ด๋‹นํ•˜๋ฏ€๋กœ M8211/2๋กœ ์•”๋“ฑ๋ก๋Œ€์ƒ์ž…๋‹ˆ๋‹ค.[์•”๋“ฑ๋ก ์ง€์นจ ๋ณ€๊ฒฝ ๋ฐ ์ฃผ์š”์‚ฌํ•ญ ๊ณต์ง€ .2014 ์ฐธ๊ณ ]
**CT ๊ฒฐ๊ณผC. Follicular lymphoma W/U- Initial CT.์ˆ˜๊ฐœ์˜ mesenteric LN๋“ค์ด ์ปค์ ธ์žˆ๊ณ  (largest: 1.9cm, arrows), mesenteric haziness๊ฐ€ ์žˆ์Œ.GI tract๋Š” collapse๋˜์–ด ์žˆ์–ด ํ‰๊ฐ€์— ์ œํ•œ ์žˆ์œผ๋‚˜ ํŠน์ด์†Œ๊ฒฌ ๋ณด์ด์ง€ ์•Š์Œ.Diffuse fatty liver๊ฐ€ ์žˆ์Œ.GB์— contrast๊ฐ€ ๋‚จ์•„์žˆ๊ณ , bile duct ๋ฐ pancreas์— ์ด์ƒ ์—†์Œ.Spleen์— ์ด์ƒ ์—†์Œ.์™ผ์ชฝ kidney์— small cyst๊ฐ€ ์žˆ์Œ.๋ณต์ˆ˜ ์—†์Œ.[ํŒ์ •]1. Enlargement of multiple mesenteric LNs with mesenteric haziness2. No apparent GI tract abnormalities**๋ณ‘๋ฆฌ๊ฒ€์‚ฌ Duodenum, "2nd part", endoscopic biopsy: Atypical lymphoid follicular hyperplasia with BCL-2 expression in lymphoid follicle , suggestive of FOLLICULAR LYMPHOMA, most likely duodenal type (see comments)๊ณจ์ˆ˜ ์นจ๋ฒ”์€ ์—†์Šต๋‹ˆ๋‹ค. ์œ„์™€ ๊ฐ™์€ ๊ฒฝ์šฐ SEER ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๋˜ํ•œ, enlargement, hypermetabolic์„ ์ „์ด๋ผ๊ณ  ๋ณด๋‚˜์š”?์ „์ด๋กœ ๊ฐ„์ฃผ ๊ฐ€๋Šฅํ•œ ์šฉ์–ด๋„ ๊ฐ™์ด ๋‹ต๋ณ€์ฃผ์‹œ๋ฉด ๊ฐ์‚ฌํ•˜๊ฒ ์Šต๋‹ˆ๋‹ค.
์˜ฌ๋ ค์ฃผ์‹  ๋‚ด์šฉ์œผ๋กœ ์›๋ฐœ๋ถ€์œ„๋ฅผ ํŒŒ์•…ํ•˜๊ธฐ ์–ด๋ ต์Šต๋‹ˆ๋‹ค.์›๋ฐœ๋ถ€์œ„๋ฅผ ํ™•์ธํ•  ์ˆ˜ ์žˆ๋Š” ์ž๋ฃŒ๋ฅผ ๋ณด์™„ํ•˜์—ฌ ์žฌ ์งˆ์˜ ํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
๋ณ‘๋ฆฌ๊ฒฐ๊ณผperineural invasion: equivocal ๋กœ ๋‚˜์˜จ๊ฒฝ์šฐ ๋ฌด์Šจ์ฝ”๋“œ ๋ถ€์—ฌํ•˜๋ฉด ๋ ๊นŒ์š”?
์ฝ”๋“œ '999' ๋กœ ๋ถ€์—ฌํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
. ET ๊ด€๋ จ ์งˆ์˜ ์žˆ์Šต๋‹ˆ๋‹ค. ํ˜„์žฌ ICD-O-3 ๊ธฐ์ค€์œผ๋กœ Essential thrombocytosis๋Š” ์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ์•„๋‹ˆ๊ณ , Essential thrombocythemia๋Š” ์•”๋“ฑ๋ก ๋Œ€์ƒ์ด๋ผ๋Š” ์ด์ „ ๋‹ต๋ณ€๋“ค ๋ชจ๋‘ ํ™•์ธํ–ˆ์Šต๋‹ˆ๋‹ค.1. ์˜๋ฌด๊ธฐ๋ก ์ƒ Essential thrombocytosis ๋งŒ ๊ธฐ์žฌ ๋˜์–ด์žˆ๋Š”๋ฐ, ๊ต์ˆ˜๋‹˜๊ป˜์„œ D473 ์œผ๋กœ ์‚ฐ์ •ํŠน๋ก€ ์ž‘์„ฑํ•˜์‹  ๊ฒฝ์šฐ 2. ๊ธฐ๋ก์— Essential thrombocytosis ์™€ Essential thrombocythemia ๊ฐ€ ๋ฒˆ๊ฐˆ์•„ ๊ฐ€๋ฉด์„œ ๊ธฐ์žฌ๋˜์–ด์žˆ๊ณ , D473 ์œผ๋กœ ์‚ฐ์ •ํŠน๋ก€๋ฅผ ์ž‘์„ฑํ•˜์‹  ๊ฒฝ์šฐ์œ„ ๋‘ ๊ฒฝ์šฐ ๋ชจ๋‘ ์•”๋“ฑ๋ก ๋Œ€์ƒ์—์„œ ์ œ์™ธ๋˜๋Š” ๊ฒƒ์ธ์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค. ์ด๋ฏธ ์˜๋ฃŒ์ง„์€ ์•”์œผ๋กœ ์ง„๋‹จํ•˜๊ณ  ์‚ฐ์ •ํŠน๋ก€๊นŒ์ง€ ์ž‘์„ฑ์„ ํ•˜์˜€์Œ์—๋„ thrombocythemia ๊ฐ€ ์•„๋‹Œ thrombocytosis ๋กœ ์ ์—ˆ๋‹ค๋Š” ์ด์œ ๋กœ ์•”๋“ฑ๋ก์„ ์•ˆํ•˜๋Š” ๊ฒƒ์ธ์ง€ ๋‹ค์‹œ ํ•œ๋ฒˆ ์งˆ๋ฌธ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ํ•ญ์ƒ ๋„์›€์ฃผ์…”์„œ ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
ICD-O-3์ƒ์œผ๋กœ Essential thrombocythemia(M9962/3)๋งŒ ๋“ฑ๋ก๋Œ€์ƒ์ด์ง€๋งŒ, ๋ณ‘์›์—์„œ Essential Thrombocytosis์™€ Essential thrombocythemia ๋‘ ์šฉ์–ด๋ฅผ ํ˜ผ์šฉํ•˜์—ฌ ์‚ฌ์šฉํ•˜๋Š” ๊ฒฝ์šฐ๊ฐ€ ๋งŽ์ด ์žˆ์Šต๋‹ˆ๋‹ค. ๋”ฐ๋ผ์„œ ์ผ€์ด์Šค๋งˆ๋‹ค ์‚ฐ์ •ํŠน๋ก€ ์ž‘์„ฑ์—ฌ๋ถ€์™€ ์ƒ๊ด€์—†์ด ์ฃผ์น˜์˜์—๊ฒŒ ์ •ํ™•ํ•œ ์ง„๋‹จ๋ช…์„ ํ™•์ธํ•˜์‹  ํ›„ ๋“ฑ๋ก์—ฌ๋ถ€๋ฅผ ๊ฒฐ์ •ํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
ํ™˜์ž Irregular mass in EM cavity๋กœ ์ˆ˜์ˆ ํ•˜์‹  ๋ถ„์œผ๋กœ, ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ๋Š” ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค.1. CTInterval slightly decreased size of about 2.1x.1.0x2.7 cm ill-defined minimal enhancing lesion along endometrium and uterine anterior wall as 1.93x0.9 cm R/O GTD including PGTT2. ์กฐ์ง๋ณ‘๋ฆฌ๊ฒ€์‚ฌUterus and salpinx, bilateral, total hysterectomy with bilateral salpingectomy : - Atypical cells in the hemorrhagic background consistent with choriocarcinoma ๊ต์ˆ˜๋‹˜๊ป˜์„œ๋Š” ์ƒ๋ณ‘์„ C58๋กœ ๋ถ€์—ฌํ•œ๋‹ค๊ณ  ํ•˜์…จ๋Š”๋ฐ, ์•”๋“ฑ๋ก์˜ ๊ฒฝ์šฐ C549, M9100/3 ์œผ๋กœ ์•”๋“ฑ๋ก ํ•˜๋ฉด ๋ ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
ํ•ด๋‹น ์ •๋ณด๋งŒ์œผ๋กœ๋Š” ์›๋ฐœ๋ถ€์œ„ ํ™•์ธ์ด ์–ด๋ ต์Šต๋‹ˆ๋‹ค. ๋‹ค๋ฅธ ์˜์ƒ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ ์ฐธ๊ณ  ๋ฐ ์ฃผ์น˜์˜๋กœ๋ถ€ํ„ฐ ์›๋ฐœ๋ถ€์œ„ ํ™•์ธ์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค. ํ•ด๋‹น์ •๋ณด๋ฟ์ด๋ผ๋ฉด C559(Uterus, NOS), M9100/3(Choriocarcinoma, NOS)๋กœ ๋“ฑ๋กํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
. M์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.Salivary gland, parotid, right, gun biopsy; Atypical epithelial and spindle cell proliferation showing AR and c-erbB2(HER2) immunoreactivity, suggestive of salivary duct carcinoma, sarcomatoid subtype (see note)ํ•ด๋‹น ์ผ€์ด์Šค์˜ ๊ฒฝ์šฐ ๋ชฐํด๋กœ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
"Suggestive" ๋Š” ์ฃผ์น˜์˜์™€ ํ˜‘์˜ํ•˜์—ฌ ์•”์œผ๋กœ ์ง„๋‹จ๋œ ๊ฒฝ์šฐ์—๋งŒ ์•”๋“ฑ๋ก์ด ๊ฐ€๋Šฅํ•œ ์šฉ์–ด์ž…๋‹ˆ๋‹ค. ์ฃผ์น˜์˜์—๊ฒŒ 'Salivary duct carcinoma' ์˜ ํ™•์ง„์—ฌ๋ถ€๋ฅผ ํ™•์ธ ํ›„ ํ™•์ง„์ด ๋งž๋‹ค๋ฉด M8500/3(Salivary duct carcinoma)๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค. [์ฐธ๊ณ : WHO Classification of Head and Neck Tumors 2017, p173]
ํ™˜์ž๋ถ„ 2019๋…„ 4์›” ๊ณจ์ˆ˜๊ฒ€์‚ฌ ์ƒ[mature B cell lymphoproliferative disorder, leukemic mantle cell lymphoma]๊ฒฐ๊ณผ ํ™•์ธ๋˜์–ด M9673/3(Mantle cell lymphoma)๋กœ ์•”๋“ฑ๋กํ•˜์˜€์Šต๋‹ˆ๋‹ค.๊ทธ ์ดํ›„์— 2023๋…„ 11์›”์— ์•ˆ๊ณผ์ ์œผ๋กœ ๋ฌธ์ œ๊ฐ€ ๋ฐœ์ƒํ•˜์—ฌ ๋‚ด์› ํ›„ ๋ˆˆ๋ฌผ์ƒ˜ ์ œ๊ฑฐ๋ฅผ ์‹œํ–‰ํ–ˆ์„ ๋•Œ, ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ ์ƒ[Eye, lacrimal gland, [right and left], excisional biopsy: Low grade B cell lymphoma, highly suspicious of extranodal marginal zone lymphoma.] ํ™•์ธ๋˜์—ˆ์Šต๋‹ˆ๋‹ค. (M9699/3) โ€ป ์•”๋“ฑ๋ก ์ง€์นจ์„œ์˜ ์กฐํ˜ˆ๊ณ„ ์•…์„ฑ์ข…์–‘์˜ ๋‹ค์ค‘์›๋ฐœ์•” ๊ตฌ๋ถ„ํ‘œ์— ๋”ฐ๋ฅด๋ฉด โ‘ M9673/3(Mantle cell lymphoma) ๊ณผ โ‘กM9699/3(extranodal marginal zone lymphoma) ์€ 'D'๋กœ ๋˜์–ด์žˆ์œผ๋ฏ€๋กœ ๋‹ค๋ฅธ์•”์œผ๋กœ ๊ฐ„์ฃผํ•˜๊ณ  M9699/3์„ ํ•œ๋ฒˆ ๋” ์•”๋“ฑ๋ก์„ ํ•ด์•ผํ• ์ง€โ€ป ๋‹ค์ค‘์›๋ฐœ์•” ์ •์˜์—์„œ ๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์œผ๋กœ ๊ฐ„์ฃผ๋˜๋Š” ์กฐ์งํ•™์  ์ง„๋‹จ๋ช…('์•”๋“ฑ๋ก์ง€์นจ์„œ' 94(2024)์ชฝ ํ‘œ26)์— ๋”ฐ๋ผ M9673/3๊ณผ M9699/3์€ ๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์ด๋ฏ€๋กœ ํ•œ๋ฒˆ ๋” ์•”๋“ฑ๋ก์„ ์•ˆํ•ด๋„๋ ์ง€ ๋‹ต๋ณ€๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
๋‹ค์ค‘์›๋ฐœ์•” ๊ทœ์น™(ํ‘œ26)์— ๋”ฐ๋ผ ๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์ด๋ฏ€๋กœ ์ถ”๊ฐ€ ์•”๋“ฑ๋กํ•˜์ง€์•Š์Šต๋‹ˆ๋‹ค.[์ฐธ๊ณ ] ํ‘œ 27. ์กฐํ˜ˆ๊ณ„ ์•…์„ฑ์ข…์–‘์˜ ๊ตฌ๋ถ„'์€ ์ด์ „ ์•”๋“ฑ๋ก ์‹œ ์ฐธ๊ณ ์šฉ์ด์—ˆ์œผ๋‚˜, ํ˜„์žฌ ์‚ฌ์šฉํ•˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค
RLL ๋ถ€์œ„ ์•”์ข… ๋ฐœ๊ฒฌ๋˜์–ด ์กฐ์ง๊ฒ€์‚ฌํ•œ ๊ฒฐ๊ณผLymph node, EBUS-TBNA biopsy : Poorly differentiated malignancy, suggestive for malignant SMARCA4 deficient undifferentiated tumor์œ„์™€ ๊ฐ™์ด ํŒ๋…๋˜์—ˆ์Šต๋‹ˆ๋‹ค.๋ชฐํด๋กœ์ง€๋ฅผ 8020/3 ์œผ๋กœ ๋ถ€์—ฌํ•˜๋Š”๊ฒŒ ๋งž๋Š”์ง€ , ์ถ”๊ฐ€๋กœ ๋ถ„ํ™”๋„๋Š” 3์ด ๋งž๋Š”์ง€ ํ™•์ธ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
"Suggestive" ๋Š” ์ฃผ์น˜์˜์™€ ํ˜‘์˜ํ•˜์—ฌ ์•”์œผ๋กœ ์ง„๋‹จ๋œ ๊ฒฝ์šฐ์—๋งŒ ์•”๋“ฑ๋ก์ด ๊ฐ€๋Šฅํ•œ ์šฉ์–ด์ž…๋‹ˆ๋‹ค.์ฃผ์น˜์˜(๋ณ‘๋ฆฌ์˜)์—๊ฒŒ 'malignantSMARCA4 deficient undifferentiated tumor' ์˜ ํ™•์ง„์—ฌ๋ถ€๋ฅผ ํ™•์ธ ํ›„ ํ™•์ง„์ด ๋งž๋‹ค๋ฉด M8044/3(Thoracic SMARCA4-deficient undifferentiated tumor), ๋ถ„ํ™”๋„ 4์œผ๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.[์ฐธ๊ณ : WHO Classification of Thoracic tumors, 5th, p111]
์•”๋“ฑ๋ก ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค!Tectal glioma ์†Œ๊ฒฌ์œผ๋กœ ์ž…์›ํ•˜์—ฌ Brain biopsy ์‹œํ–‰ํ•œ ๋ถ„์œผ๋กœ, ์กฐ์ง๊ฒ€์‚ฌ์ƒ Low- grade astrocytic tumor ํ™•์ธ๋˜์—ˆ์œผ๋‚˜ ํ•ด๋‹น ์ง„๋‹จ์— ํ•ฉ๋‹นํ•œ M code๊ฐ€ ์—†์Šต๋‹ˆ๋‹ค. ์˜์ƒ๊ฒ€์‚ฌ์—์„œ ํ™•์ธ๋œ glioma๋กœ ์•”๋“ฑ๋ก์„ ํ•œ๋‹ค๋ฉด M9380/3 ๋˜๋Š” M9400/3์œผ๋กœ ๋“ฑ๋กํ•  ์ˆ˜ ์žˆ๋Š”์ง€ M code ํ™•์ธ์„ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค!1. Brain MRI(2024.02.16.): Diffuse thick tectal plate of midbrain.- high/low SI on T2/T1-WI- extend to tegmentum, esp. Lt.- obliteration of cerebral aqueduct with acute obstructive hydrocephalus- dilatation of 3rd and lateral ventricles with transependymal edema; Tectal glioma2. Brain CT(2024.02.26.): Known diffuse thick tectal plate of midbrain.- obliteration of cerebral aqueduct with acute obstructive hydrocephalus-dilatation of 3rd and lateral ventricles with transependymal edema; grossly n.c. since 2024-02-01 brain CT; Tectal glioma3. Brain, biopsy(2024.02.28.);Proliferation of glial cells with mild cytologic atypia, suggestive of Low-grade astrocytic tumor(see note)*Note : The diagnosis of specific entity is difficult due to smaple size.
"Suggestive" ๋Š” ์ฃผ์น˜์˜์™€ ํ˜‘์˜ํ•˜์—ฌ ์•”์œผ๋กœ ์ง„๋‹จ๋œ ๊ฒฝ์šฐ์—๋งŒ ์•”๋“ฑ๋ก์ด ๊ฐ€๋Šฅํ•œ ์šฉ์–ด์ž…๋‹ˆ๋‹ค.์ฃผ์น˜์˜(๋ณ‘๋ฆฌ์˜)์—๊ฒŒ 'Low-grade astrocytic tumor' ์˜ ํ™•์ง„์—ฌ๋ถ€๋ฅผ ํ™•์ธ ํ›„ ํ™•์ง„์ด ๋งž๋‹ค๋ฉด M9400/3(Astrocytoma, NOS)์œผ๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.
Gallbladder and liver, radical cholecystectomy; Poorly differentiated malignant epithelioid neoplasm ; suggestive of adenocarcinoma, poorly differentiated 1) Gross type: massive 2) Location of tumor: entire gallbladder 3) Size of tumor: 6.7 x 5.0 x 4.5 cm 4) Tumor extent: a) gallbladder: perforation of visceral peritoneum b) liver: invasion of parenchyma 5) Surgical margins: hepatic resection margin involved by carcinoma (Safety margin: cystic duct margin: 1.0 cm) 6) Lymph node: not submitted 7) Lymphatic invasion: present, extensive 8) Venous invasion: present 9) Perineural invasion: not identified 10) Tumor border: infiltrative 11) Stromal reaction: neutrophilic 12) Pre-existing dysplasia: not identified 13) Associated findings: mucin production 14) Pathological stage (by AJCC 8th Ed.): pT3adenocarcinoma๋กœ ๋ณด๋ฉด ๋˜๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค^^
"Suggestive" ๋Š” ์ฃผ์น˜์˜์™€ ํ˜‘์˜ํ•˜์—ฌ ์•”์œผ๋กœ ์ง„๋‹จ๋œ ๊ฒฝ์šฐ์—๋งŒ ์•”๋“ฑ๋ก์ด ๊ฐ€๋Šฅํ•œ ์šฉ์–ด์ž…๋‹ˆ๋‹ค.์ฃผ์น˜์˜(๋ณ‘๋ฆฌ์˜)์—๊ฒŒ 'adenocarcinoma' ์˜ ํ™•์ง„์—ฌ๋ถ€๋ฅผ ํ™•์ธ ํ›„ ํ™•์ง„์ด ๋งž๋‹ค๋ฉด M8140/3 ์œผ๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.
์ˆ˜๊ณ ๋งŽ์œผ์‹ญ๋‹ˆ๋‹ค. ๋ณ‘๋ฆฌ๊ฒ€์‚ฌ๊ฒฐ๊ณผ ๊ด€๋ จ ๋ชฐํด๋กœ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. DIAGNOSIS Larynx, vocal cord, left, biopsy (frozen) Dysplastic squamous ep i the I ium with probable koilocytosis - histologic evaluation is limited due to poor orientation. DIAGNOSIS Larynx, vocal cord, #1, left, laryngo microscopic surgery : Malignant tumor with ep ithelial-mesenchymal differentiation (See NOTE). Larynx, vocal cord, #2, left, laryngo microscopic surgery Low grade dysplasia. # NOTE: Sect ion discloses multi -nodular arrangement of atypical plasmocytoid cells with freq uent mitotic figures. The nodules are surrounded by atypical spindle cells with ulcerated SU rface. The tumor cells show heterogenous immunohistochemical findings showing both epithelia I and mesenchymal different iation. Cons idering the histologic and immunohistochemical findin gs, the possibility of myoepi thelial carcinoma can not be ruled out firstly among malignant tumors with ep i thelial-mesenchymal differentiation. Please do excisional biopsy for more def ined diagnosis if possible. *์ถ”๊ฐ€๊ธฐ์žฌ์‚ฌํ•ญ ์™ธ๋ž˜๊ฒฝ๊ณผ: myoepithelial carcinoma suspicious. ๋กœ ์ง„๋‹จ๋จํ•ด๋‹น์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ์ง€๋กœ Myoepithelial carcinoma, M89823 ์ ์šฉ๊ฐ€๋Šฅ์—ฌ๋ถ€ ๋ฐ ๋ชฐํด๋กœ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
๋ณ‘๋ฆฌํ•™์ ์œผ๋กœ Myoepithelial carcinoma๊ฐ€ ํ™•์ง„๋œ ๊ทผ๊ฑฐ๋ฅผ ํ™•์ธํ•˜์‹  ํ›„, ๊ทผ๊ฑฐ๊ฐ€ ์žˆ๋‹ค๋ฉด M8982/3 (Malignant myoepithelioma)๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค. ํ•ด๋‹น ์ •๋ณด๋ฟ์ด๋ผ๋ฉด ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ์— ๋”ฐ๋ผ M8000/3 (Neoplasm, malignant) ์œผ๋กœ ๋“ฑ๋กํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
penile area ์— mass ๊ฐ€ ๋ฐœ๊ฒฌ๋˜์–ด ๋‘๋ฒˆ ์กฐ์ง๊ฒ€์‚ฌ ์‹œํ–‰ํ•˜์˜€์Šต๋‹ˆ๋‹ค.์™ธ๋ž˜- ์กฐ์ง๊ฒ€์‚ฌSkin, Excision: Papillary squamous cell carcinoma in situ, at least, possibly HPV-associated์ž…์› - ์ข…์–‘์ ˆ์ œ์ˆ  ํ›„ ์กฐ์ง๊ฒ€์‚ฌPenis, Excision: - Histologic type: Penile intraepithelial neoplasia, HPV-associated (#4,5) - Margins: Uninvolved by tumor cells (#1-3,6-30) - Additional findings: Focal warty (condylomatous) growth is noted.ํ•ด๋‹น ์กฐ์ง๊ฒ€์‚ฌ๋Š” ์•”๋“ฑ๋ก ๋Œ€์ƒ์ธ์ง€ , ๋Œ€์ƒ์ด๋ผ๋ฉด ๋ชฐํด๋กœ์ง€ ์ฝ”๋“œ๋ฅผ ์–ด๋–ค๊ฑธ๋กœ ์ฃผ์–ด์•ผ ํ•˜๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
C60.9(Skin of penis), M8052/2 (Papillary squamous cell carcinoma in situ) ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
1. Colon, right, hemicolectomy: ADENOCARCINOMA, moderately differentiated 1) Location: cecum 2) Gross type: ulcerofungating 3) Size: 3.9x3.7 cm 4) Depth of invasion: invades subserosa (pT3) 5) Resection margin: free from carcinoma safety margin: proximal, 4.6 cm ; distal, 28.2 cm 6) Regional lymph node metastasis : - METASTASIS to 6 out of 14 regional lymph nodes (pN2a) (6/14 : pericolic, 14; "IMA LN": 0) - Number of Extramural Tumor Deposits: 1 7) Lymphatic invasion: present 8) Venous invasion: not identified 9) Perineural invasion: not identified 10) Tumor budding : positive (intermediate 5-9) 11) Micropapillary component: no (0%) 12) Tumor border: infiltrative 13) . Tubular adenoma with low grade dysplasia ; at cecum - size: 0.6x0.6cm - resected margin: free from adenoma . Tubular adenoma with high grade dysplasia - size: 2.1x1.6cm - resected margin: free from adenoma 13) Immune response: Intratumoral lymphocyte (minimal) / Crohn like resection (absent) 14) Associated findings : none 15) Pathologic staging: pT3 N2a 16) Chronic active appendicitis2. "Omentum": No tumor invasion present3. "Omental mass": Dystriophic calcification---------------------------------------1&2. Colon, sigmoid & "Distal margin", anterior resection: MUCINOUS ADENOCARCINOMA, moderately differentiated 1) Location: sigmoid colon 2) Gross type: polypoid 3) Size: 2.5x2x1.5 cm 4) Depth of invasion: invades muscularispropria(pT2) 5) Resection margin: free from carcinoma safety margin: proximal, 9.5 cm ; distal, 3.3 cm ; circumferential, 15 mm 6) Regional lymph node metastasis : - No metastasis in all 13 regional lymph nodes(pN0) 7) Lymphatic invasion: not identified 8) Venous invasion: not identified 9) Perineural invasion: not identified 10) Tumor budding : negative 11) Micropapillary component: no 12) Tumor border: infiltrative 13) Pre-existing adenoma : Tubular adenoma with high grade dysplasia 1) size : 1.2x1x0.6 cm 2) resection margin : free from adenoma 14) Immune response: Intratumoral lymphocyte (minimal) 15) Separate lesion: Tubular adenoma with low grade dysplasia 1) size : 1.1x0.6cm 2) resection margin : free from adenoma 16) Pathologic staging: pT2 N02023.06.05 ์ˆ˜์ˆ ํ•˜๊ณ , 2023.10.12 ์ˆ˜์ˆ ํ•œ ํ™˜์ž์ธ๋ฐ ์กฐ์ง๊ฒ€์‚ฌ ๊ฒฐ๊ณผ๊ฐ€ ์ด๋ ‡๊ฒŒ ๋‚˜์™”๋Š”๋ฐ,cecum ๋ถ€์œ„์— M8140/3 (adenocarcinoma)sigmoid colon ๋ถ€์œ„์— M8253/3 (mucinous adenocarcinoma)์ด๋ ‡๊ฒŒ ๋‹ค์ค‘์›๋ฐœ์•”์œผ๋กœ ์•”๋“ฑ๋ก์„ ๊ฐ๊ฐ ํ•ด์•ผ ํ•˜๋Š”์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค!
C18.9(Colon, NOS), M8480/3 Mucinous adenocarcinoma(except of lung M8253/3) ์œผ๋กœ ํ•œ๋ฒˆ๋งŒ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
Esophagus, 24 cm to 32 cm from upper incisor, endoscopic biopsy; POORLY DIFFERENTIATED CARCINOMA with focal neuroendocrine differentiation์†Œ๊ฒฌ์œผ๋กœ M8020/3 ๋กœ ๋ถ€์—ฌํ•˜๋ฉด ๋ ๊นŒ์š”?
๋„ค, M8020/3 (Carcinoma, poorly differentiated, NOS) ์œผ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
. ๊ฐ‘์ƒ์„ ์•” ๋ถ„ํ™”๋„ ๊ด€๋ จํ•˜์—ฌ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๋ณ‘๋ฆฌ๊ฒ€์‚ฌ๋Š” ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค.DIAGNOSIS:Thyroid, total thyroidectomy:Papillary carcinomas (x2)with focal poorly differentiated carcinoma component1) Tumor location: left lobe (x2)ํ•ด๋‹น ์ผ€์ด์Šค์—์„œ ํ˜•ํƒœํ•™์€ 8260/3์„ ๋ถ€์—ฌํ•˜๊ณ , ๋ถ„ํ™”๋„๋Š” with focal poorly differentiated carcinoma component๋ฅผ ๊ณ ๋ คํ•˜์—ฌ 3์„ ๋ถ€์—ฌํ•˜๋ฉด ๋˜๋Š”์ง€ ์•„๋‹ˆ๋ฉด 9๋ฅผ ๋ถ€์—ฌํ•ด์•ผํ•˜๋Š”์ง€ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค!
M8337/3 Poorly differentiated thyroid carcinoma(C73.9) , ๋ถ„ํ™”๋„ 3์œผ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
์กฐ์ง๊ฒ€์‚ฌ ๊ฒฐ๊ณผ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค.humerus head, excision1. leiomyocarcoma with extension to periosteum2. destruction of cortical boneintramedullary bone1. no tumor present์งˆ๋ฌธ์€ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค. 1. ์ด๋Ÿฐ ์ƒํ™ฉ์—์„œ leiomyosarcoma์˜ ๊ฒฝ์šฐ ๊ฒฐํ•ฉ์กฐ์ง์˜ ์•…์„ฑ์‹ ์ƒ๋ฌผ ์ฝ”๋“œ๋กœ ๋ถ„๋ฅ˜๊ฐ€ ๋˜์–ด C491(Connective tissue maligant, upper limb) ์œผ๋กœ ์›๋ฐœ ๋“ฑ๋ก์„ ํ•˜๋Š”๊ฒŒ ๋งž๋Š”์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค. 2. ์ €ํฌ ์ž„์ƒ๊ต์ˆ˜๋‹˜๊ป˜์„œ๋Š” bone์˜ ์•…์„ฑ์‹ ์ƒ๋ฌผ๋กœ ๋ณด์‹ ๋‹ค๊ณ  ํ•˜์…จ๋Š”๋ฐ leiomyosarcoma๊ฐ€ bone์˜ ์•…์„ฑ ์‹ ์ƒ๋ฌผ๋กœ๋„ ๋ณผ์ˆ˜ ์žˆ๋Š”๊ฑด์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค. (๊ฒฐํ•ฉ์กฐ์ง์—์„œ๋งŒ ๋ฐœ์ƒํ•˜๋Š”๊ฒŒ ์•„๋‹ˆ๋ผ ๋ผˆ์—์„œ๋„ ๋ฐœ์ƒํ•  ์ˆ˜ ์žˆ๋Š”๊ฑด์ง€..)
leiomyosarcoma๊ฐ€ bone์— ๋ฐœ์ƒ๋˜๊ธฐ๋Š”ํ•˜๋‚˜ ๋งค์šฐ ํฌ๊ท€ํ•œ ์ผ€์ด์Šค๋กœ ๋ณด๊ณ ๋˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ์›๋ฐœ๋ถ€์œ„๊ฐ€ connective tissue์—์„œ ๋ฐœ์ƒ๋œ ๊ฒƒ์ธ์ง€, bone์—์„œ ๋ฐœ์ƒ๋œ ๊ฒƒ์ธ์ง€ ๋‹ค์‹œํ•œ๋ฒˆ ํ™•์ธํ•˜์‹  ํ›„ ๋“ฑ๋กํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.๋งŒ์•ฝ bone์—์„œ ๋ฐœ์ƒํ•œ๊ฒƒ์ด ๋งž๋‹ค๋ฉด, C400 (Humerus)๋กœ ๋ถ€์—ฌํ•ด์ฃผ์‹œ๊ณ  ๋น„๊ณ (bigo)๋ž€์— Bx ๊ฒฐ๊ณผ๋ฅผ ๊ธฐ์žฌํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
์œ ๋ฐฉ์•”์œผ๋กœ ์ˆ˜์ˆ ํ•œ ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค .BX:Breast, ( left ), breast conserving operation with axillary staging: - INVASIVE LOBULAR CARCINOMA, NUCLEAR GRADE 2/3, HISTOLOGIC GRADE 2/3, 2.5 x 2 x 1.1 cm, with 1) intraductal component: 5 % / EIC (-), nuclear grade 2/3, without necrosis 2) lymphovascular invasion: not identified 3) tumor infiltrating lymphocytes: < 10 % 4) involvement of skin ( dermis ) 5) No metastasis in 2 lymph nodes ( 0/2 ) ๊ทธ๋ฆฌ๊ณ  ์˜์‚ฌ์ง„๋‹จ์—์„œ๋Š” ์•„๋ž˜์™€ ๊ฐ™์ด TNM๋ถ„๋ฅ˜์‹œ T2๋กœ ๊ธฐ์žฌํ•˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. .op name: Lt central lumpectomy SNB (ADM 8cc apply) clinico-pathology: ILC. T2 (2.5 cm )N0 ( 0 / 2)M0 Stage II A Gr 2 LVi(-) RM(-) ER/PR/HER2 : 8/7/N Ki-67 : 20 ~ 30% ** involvement of skin - skin ํฌํ•จ elliptical incision์œผ๋กœ ์ ˆ๊ฐœํ•จ ์งˆ๋ฌธ์‚ฌํ•ญ) ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ skin involve๋กœ ๋‚˜์™”์œผ๋ฉฐ, ์˜์‚ฌ๊ธฐ๋ก์—์„œ๋Š” skin involve๋ฅผ ํฌํ•จํ•˜์ง€ ์•Š๋Š” T2๋กœ ๊ธฐ์žฌํ•˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค ์˜์‚ฌ๊ธฐ๋ก์€ T2์ด์ง€๋งŒ, ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ๋ฅผ ๋ฐ˜์˜ํ•˜์—ฌ SEER'2'๋กœ ๋ถ€์—ฌํ•  ์ˆ˜ ์žˆ๋Š”์ง€ ์งˆ๋ฌธ๋“œ๋ฆฝ๋‹ˆ๋‹ค ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค
๋„ค, SEER 2๋กœ ๋ถ€์—ฌํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.[์ฐธ๊ณ  SEER summary sataging manual 2000 p.187 code 2 "Local infiltration of dermal lymphatics adjacent to primary tumor involving skin by direct extension" ]
DCIS์—์„œ intraductal papilloma ํ™•์ธ ์‹œ, M์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.1) CASE 1 Breast, right, excision; 1. Ductal carcinoma in situ with 1) Tumor extent: 0.7x0.5cm 2) Tumor site: 9 o'clock 3) Van Nuys classification group 1/3 (1) Nuclear grade: 1/3 (2) Necrosis : absent 4) Involvement of skin: skin not submitted 5) Clear surgical resection margin - Resection margin <1mm from DCIS 6) Lymph node: not submitted 7) Microcalcification: present 2. Intraductal papilloma with atypical ductal hyperplasia2) CASE 2 Breast, right, excision; 1. Ductal carcinoma in situ involving intraductal papilloma--> case 2์™€ ๊ฐ™์ด DCIS์— intraductal papilloma๊ฐ€ ํฌํ•จ๋˜์–ด์žˆ๋‹ค๊ณ  ํ‘œํ˜„๋˜์–ด ์žˆ๋Š” ๊ฒฝ์šฐ์—๋Š”, ์ด์ „ ์•”๋“ฑ๋ก๊ต์œก์„ผํ„ฐ ๋‹ต๋ณ€์„ ์ฐธ๊ณ ํ•˜์—ฌ M8503/2๋กœ ๋ถ€์—ฌํ•˜๊ณ , --> case 1๊ณผ ๊ฐ™์€ ๊ฒฝ์šฐ์—๋Š”, ํ•œ ๋ถ€์œ„์—์„œ ๋‘๊ฐœ์˜ ์กฐ์งํ•™์  ์ง„๋‹จ์ด ํ™•์ธ๋˜์–ด,์ด๋Ÿฐ ๊ฒฝ์šฐ M8500/2๋กœ ๋ถ€์—ฌํ• ์ง€, case2 ์™€ ๊ฐ™์ด M8503/2๋กœ ๋ถ€์—ฌํ•˜๋Š”๊ฒŒ ๋งž์„ ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
CASE 1: M8500/2 Ductal carcinoma in situ, NOS๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค. CASE 2: M8503/2 (Intraductal papilloma with DCIS)๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
Lymph node, "parotid gland", neck, level IIb, right, US-guided gun biopsy; Diffuse large B-cell lymphoma, not otherwise specified, activated B-cell type, with Myc/BCL2 double expressor phenotype, and Follicular large B-cell lymphoma---------------------------------, ์ƒ๊ธฐ ๊ฒฐ๊ณผ์— ๋Œ€ํ•ด ์•”๋“ฑ๋ก ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.DLBCL & Follicular large b-cell lymphoma ์†Œ๊ฒฌ์ด ํ˜ผ์žฌ๋œ ์ƒ๊ธฐ ๊ฒฐ๊ณผ์— ๋Œ€ํ•ด ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค. - M9680/3 Diffuse large b-cell lymphoma - M9675/3 Malignant lymphoma, mixed cell type, diffuse - M9690/3 Malignant lymphoma, follicular, NOS - M9691/3 Malignant lymphoma, mixed cell type, follicular ๋‘˜๋‹ค 9๋ฒˆ ๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์œผ๋กœ ๊ฐ„์ฃผํ•˜๊ณ , ๋‹จ์ผ ์•”๋“ฑ๋ก์œผ๋กœ ํ•˜๋ฉด ๋ ์ง€.. ๊ทธ๋ ‡๋‹ค๋ฉด M์ฝ”๋“œ๋Š” ์–ด๋–ป๊ฒŒ ๋ถ€์—ฌํ•ด์•ผ ํ•  ์ง€ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
๊ด€๋ฆฌ์ž ๋‹ต๋ณ€ ์—†์Œ
[Bx ๊ฒฐ๊ณผ] DIAGNOSIS : Thyroid gland, total thyroidectomy; 1. Differentiated high-grade thyroid carcinoma(DHGTC), unifocal, right lobe With 1) Size: 3.1 x 2.7 cm in diameter 2) Mixed papillary, follicular, oncocytic and solid pattern M code ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
M8010/3 (Carcinoma, NOS) ์œผ๋กœ ๋ถ€์—ฌํ•ฉ๋‹ˆ๋‹ค.
. ์•”๋“ฑ๋ก ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.ํƒ€๋ณ‘์›์—์„œ * 2022.10.25 - Breast, left, 2 o'clock, core biopsy : INVASIVE DUCTAL CARCINOMA, NUCLEAR GRADE 3/3, histologic grade 3/3 T2N0Mx์˜ ๊ฒ€์‚ฌ์†Œ๊ฒฌ์œผ๋กœ ํƒ€๋ณ‘์›์—์„œ ํ•ญ์•”์น˜๋ฃŒ ์ง„ํ–‰ํ•˜์…จ์Šต๋‹ˆ๋‹ค.์ดํ›„์— ๊ฐ™์€ ๋ณ‘์›์—์„œ* 2023.05.16 - Breast, left, conserving surgery with sentinel lymph node biopsy ๋ฅผ ์ง„ํ–‰ํ–ˆ์œผ๋ฉฐ ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ๋กœ status post neoadjuvant chemotherapy Ductal carcinoma in situ, flat type, multifocal :1)tumor extent: 2.8 cm (overall cancer cellularity: 1%) (ypTis)2)nuclear grade : intermediate without necrosis3) Van Nuys classification group : 1 / 34) Lymphovascular invasion: absent5) microcalcification in benign duct and stroma6) negative resection margins7) no metastasis in 4 regional lymph nodes์˜ ๊ฒฐ๊ณผ๊ฐ€ ๋‚˜์™”์Šต๋‹ˆ๋‹ค.์ดํ›„ 2023.06.12์— ๋ฐฉ์‚ฌ์„  ์น˜๋ฃŒ๋ฅผ ์œ„ํ•ด ์ €ํฌ ๋ณ‘์›์— ์˜ค์…จ์Šต๋‹ˆ๋‹ค.์ด ๊ฒฝ์šฐ ์ดˆ์ง„๋…„์›”์ผ๊ณผ M code๋Š” 2022.10.25 ์™€ M8500/3์ด ๋งž์„๊นŒ์š” ์•„๋‹ˆ๋ฉด ์ดˆ์ง„๋…„์›”์ผ์€ 2022.10.25 ์ด์ง€๋งŒ M code๋Š” M8500/2 ๊ฐ€ ๋งž์„๊นŒ์š”?๋ฐ”์˜์‹œ๊ฒ ์ง€๋งŒ ๋‹ต๋ณ€ ๋‚จ๊ฒจ์ฃผ์‹œ๋ฉด ๊ฐ์‚ฌํ•˜๊ฒ ์Šต๋‹ˆ๋‹ค.
์ดˆ์ง„์—ฐ์›”์ผ: 2022.10.25 , ์กฐ์งํ•™์ ์ง„๋‹จ๋ช… M8500/3 ์œผ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
๋ฆผํฌ๋งˆ ์•”๋“ฑ๋ก ๊ด€๋ จ ์งˆ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. 15๋…„๋„์— Vocal cord, malignant non-Hodgkin lymphoma, diffuse large B cell lymphoma์กฐ์ง๊ฒ€์‚ฌ ๋ณด๊ณ ๋˜์–ด ์•”๋“ฑ๋ก๋œ ํ™˜์ž์ž…๋‹ˆ๋‹ค.ํ•ญ์•”์น˜๋ฃŒ ์ดํ›„ ์™ธ๋ž˜ f/u์ค‘์— CT์ƒ Increased size of some LNs in Rt axilla ์†Œ๊ฒฌ์œผ๋กœ Breast ๋ฐ Lymph node, axilla, right, excision; Consistent with malignant lymphoma, marginal zone B cell lymphoma์กฐ์ง๊ฒ€์‚ฌ ๋ณด๊ณ ๋˜์–ด ํ•ญ์•”์น˜๋ฃŒ ์‹œ์ž‘ํ•˜์˜€์Šต๋‹ˆ๋‹ค.15๋…„๋„ ๋‹น์‹œ์—๋Š” ์›๋ฐœ์ด ํ›„๋‘์ชฝ์— ๋“ฑ๋ก๋˜์–ด์žˆ๋Š”๋ฐ์•”๋“ฑ๋ก์„ ์ถ”๊ฐ€๋กœ ํ•ด์•ผํ•˜๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์ด๋ฏ€๋กœ ์ถ”๊ฐ€ ์•”๋“ฑ๋กํ•˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค.
49์„ธ ๋‚จ์žํ™˜์ž๋กœ Malignant melanoma, Multiple meta ์ง„๋‹จ์€ ๋ฐ›์€ ํ™˜์ž๋กœ์™ธ๊ณผ/๋ณ‘๋ฆฌ๊ณผ ๊ต์ˆ˜๋‹˜์€ ์›๋ฐœ๋ถ€์œ„๋ฅผ small bowel ๋˜๋Š” stomach ์ค‘ small bowel ๊ฐ€๋Šฅ์„ฑ ์žˆ์œผ๋‚˜ ์ •ํ™•ํžˆ ์•Œ ์ˆ˜ ์—†๋‹ค๊ณ  ๋‹ต๋ณ€ ๋ฐ›์Œ์›๋ฐœ : ์›๋ฐœ๋ฏธ์ƒํ˜ˆ์•ก์ข…์–‘ํ•™๊ณผ ๊ต์ˆ˜๋‹˜์€ ์•”์ด small bowel ๊ณผ stomach ๊ฑธ์ณ์žˆ๊ณ , ์•”์˜ ์‹œ์ž‘์ด small bowel์ธ์ง€ stomach๋Š” ์•Œ ์ˆ˜ ์—†๋‹ค๊ณ  ๋‹ต๋ณ€ ๋ฐ›์Œ์›๋ฐœ : gastrointestinal tract ์ด๋Ÿด ๊ฒฝ์šฐ ์›๋ฐœ๋ถ€์œ„๋ฅผ C800 MUO(metastatic cancer of unknown origin) ๊ณผ C268 Cancer of overlapping lesion of digestive system ์ค‘ ์–ด๋–ค ๋ถ€์œ„๋กœ ๋“ฑ๋ก ํ• ์ง€ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
C80.9(Unknown primary site)๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผOvary and salpinx, right, salpingo-oophorectomy :1. Seromucinous cystadenofibroma, ovary with size: 4.2 x 3.0 cm๋กœ ๋ณด๊ณ  ๋˜์–ด ์ข…์–‘ํ•™ ๋ถ„๋ฅ˜ ์ฑ…์ž์— M ์ฝ”๋“œ ํ™•์ธํ•œ ๊ฒฐ๊ณผMucinous cystadenofibroma์™€ Serous cystadenofibroma๋งŒ ๋ถ„๋ฅ˜๋˜์–ด ์žˆ๊ณ Seromucinous cystadenofibroma ๋Š” ๋”ฐ๋กœ ์ฝ”๋“œ์•ˆ๋‚ด๊ฐ€ ๋˜์–ด์žˆ์ง€ ์•Š์•„M code ์งˆ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
ํ•ด๋‹น ์ง„๋‹จ๋ช…์€ ์•”๋“ฑ๋ก๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค. ์งˆ๋ณ‘๋ถ„๋ฅ˜์ฝ”๋“œ๋ฌธ์˜๋Š” ๋Œ€ํ•œ๋ณด๊ฑด์˜๋ฃŒ์ •๋ณด๊ด€๋ฆฌ์‚ฌํ˜‘ํšŒ์— ๋ฌธ์˜๋ฐ”๋ž๋‹ˆ๋‹ค.
. ์ „๋ถ๋Œ€ํ•™๊ต๋ณ‘์› ์˜๋ฌด๊ธฐ๋กํŒ€ ์ด์ข…๋ฏผ์ž…๋‹ˆ๋‹ค.Mixed-phenotype acute leukaemia with t(11;19)(q23;p13.1);KMT2A-ELLMcode๋ฅผ ์–ด๋–ป๊ฒŒ ์ค˜์•ผ ํ• ๊นŒ์š”? ๊ต์ˆ˜๋‹˜์€ M9808/3์œผ๋กœ ๋ณด๊ณ  ๊ณ„์‹ญ๋‹ˆ๋‹ค.Mcode ์—‘์…€ ํŒŒ์ผ ์ฒจ๋ถ€ํ•˜์˜€์Šต๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
M9080/3์œผ๋กœ ๋ณด์‹  ๊ทผ๊ฑฐ๋ฅผ ํ™•์ธํ•˜์‹  ํ›„, ๊ทผ๊ฑฐ๊ฐ€ ์—†๋‹ค๋ฉด M9801/3(Acute leukemia, NOS)์œผ๋กœ ๋“ฑ๋กํ•ด์ฃผ์‹œ๊ธฐ๋ฐ”๋ž๋‹ˆ๋‹ค.
์„ ์ƒ๋‹˜ . ๊ฐ‘์ƒ์„  ํ˜•ํƒœํ•™ ๊ด€๋ จํ•˜์—ฌ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.์ˆ˜์ˆ  ํ›„ ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋Š” ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค.MICRO (8 HE)DIAGNOSIS:Thyroid, total thyroidectomy:Papillary carcinomawith poorly differentiated carcinoma component (5%)1) Tumor location: right lobe์•”๋“ฑ๋ก ์ง€์นจ ์ƒ with ~ component (5%)๋Š” ์ฝ”๋“œ์— ์˜ํ–ฅ์„ ์ฃผ์ง€์•Š์•„ 8260/3์œผ๋กœ ๋ถ€์—ฌํ•˜๋Š” ๊ฒƒ์œผ๋กœ ์•Œ๊ณ  ์žˆ์œผ๋‚˜, ์ฃผ์น˜์˜ ์„ ์ƒ๋‹˜๊ป˜์„œ๋Š” Poorly differentiated thyroid carcinoma (8337/3) ์œผ๋กœ ์ง„๋‹จ ๋“ฑ๋กํ•ด์ฃผ์…จ์Šต๋‹ˆ๋‹ค.์ด๋Ÿฌํ•œ ๊ฒฝ์šฐ์—๋Š” ์•”๋“ฑ๋ก ์‹œ, ์•„๋ž˜ ํ˜•ํƒœํ•™ ์ค‘ ์–ด๋– ํ•œ ์ฝ”๋“œ๋กœ ์•”๋“ฑ๋กํ•ด์•ผํ•˜๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.8260/3 : Papillary adenocarcinoma, NOS ์œ ๋‘์ƒ ์„ ์•”์ข… NOS8337/3 : Poorly differentiated thyroid carcinoma(C73.9) ์†Œ๋ถ„ํ™”๋œ ๊ฐ‘์ƒ์„  ์•”์ข…๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
M8337/3(Poorly differentiated papillary carcinoma(C73.9))๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.์ฐธ๊ณ -[WHO Classification of Tumours of Endocrine Organs 4th edition] p.100
์•”๋“ฑ๋ก ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๋ณธ์›CS์—์„œ ์ˆ˜์ˆ  ํ•˜์‹  ํ™˜์ž ๋ถ„ Bx๊ฒฐ๊ณผ Pericardium, VATS pericardiostomy: Fibrosis with infiltration of a few foamy histiocytes, R/O Involvement of Erdheim-Chester diseaseTissue labelled as "mediastinal fat", excision: Lymph node with no tumor (0/2)Lung, middle lobe, right, VATS wedge resection: Erdheim-Chester disease์ตœ์ข…์ง„๋‹จ Erdheim-Chester disease๋กœ, ์ด๋Ÿฐ ๊ฒฝ์šฐ ์›๋ฐœ ๋ถ€์œ„๋ฅผ Lung์œผ๋กœ ๋ถ€์—ฌํ•ด๋„ ๋˜๋Š”์ง€ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
๋ณ„๋„์˜ ์›๋ฐœ๋ถ€์œ„์— ๋Œ€ํ•œ ๋ช…์‹œ๊ฐ€ ์—†๋‹ค๋ฉด, C80.9 ๋กœ ์›๋ฐœ๋ถ€์œ„ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.(์ž๋ฌธ๊ฒฐ๊ณผ ์ฐธ๊ณ )Erdheim-Chester disease๋Š” clonal systemic histiocytosis๋กœ bone, soft tissue, pituitary, lung, heart, skin ๋“ฑ์„ ํฌํ•จํ•˜์—ฌ ์ „์‹  ์–ด๋–ค ๊ธฐ๊ด€์ด๋‚˜ ์—ฐ๋ถ€์กฐ์ง์„ ์นจ๋ฒ”ํ•˜์—ฌ ๋ฐœ์ƒํ•˜๋Š” ์ข…์–‘์œผ๋กœ hematolymphoid malignancy์— ํ•ด๋‹นํ•˜๋Š” ์•…์„ฑ์งˆํ™˜์ž…๋‹ˆ๋‹ค. ๋Œ€๋ถ€๋ถ„ ๋ฐœ๊ฒฌ๋  ๋•Œ ์—ฌ๋Ÿฌ ์žฅ๊ธฐ์˜ ์ „์‹ ์  ์นจ๋ฒ”์˜ ์†Œ๊ฒฌ์„ ๋ณด์ด๋ฏ€๋กœ ์›๋ฐœ๋ถ€์œ„๋ฅผ ํŠน์ •ํ•  ์ˆ˜ ์—†์Šต๋‹ˆ๋‹ค.
์ƒํ–‰๊ฒฐ์žฅ์•”์— ๊ฐ„์ „์ด๊ฐ€ ์žˆ๋Š” ํ™˜์ž์˜์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ(์ƒ๊ฒ€, ์›๋ฐœ๋ถ€์œ„)์—์„œ high grade dysplasia๊ฐ€ ๋‚˜์™”๋Š”๋ฐ๋”์ด์ƒ ์ถ”๊ฐ€ ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ๋Š” ์—†์—ˆ์Šต๋‹ˆ๋‹ค.์ด๊ฒฝ์šฐ ์š”์•ฝ๋ณ‘๊ธฐ7, ์ตœ์ข…์ง„๋‹จ๋ฐฉ๋ฒ•(์›๋ฐœ๋ถ€์œ„์กฐ์งํ•™์ ๊ฒ€์‚ฌ), M81483(?)์ธ์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค.
์ง„๋‹จ๋ฐฉ๋ฒ• 1, ์กฐ์งํ•™์ ์ง„๋‹จ๋ช… M8000/3(Neoplasm, malignant), ์š”์•ฝ๋ณ‘๊ธฐ 7๋กœ ๋“ฑ๋กํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
2024.01.06์ผ ๋‚ด์‹œ๊ฒฝ ์กฐ์ง๊ฒ€์‚ฌ์—์„œ DLBCL ์ง„๋‹จํ•˜์— 3์›” ๋ณตํ†ต์œผ๋กœ ์†Œ์žฅ ์ ˆ์„ธ์ˆ  ์‹œํ–‰ํ•˜์—ฌ Extranodal marginal zone B cell lymphoma ์ง„๋‹จ๋ฐ›์•„ ์›๋ฐœ๋ถ€์œ„ ๋ฐ Mcode ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค. 2024.01.06์ผ Stomach, pylorus, endoscopic biopsy: Diffuse large B cell lymphoma.2024.03.04์ผ Small intestine, segmental resection: Extranodal marginal zone B cell lymphoma.
์›๋ฐœ๋ถ€์œ„๋Š” ํ•ด๋‹น์ •๋ณด ์™ธ์— ์ถ”๊ฐ€์ ์œผ๋กœ lymph node์˜ ์นจ๋ฒ”์—ฌ๋ถ€๋ฅผ ํ™•์ธ์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค. ์นจ๋ฒ”์ด ์žˆ๋‹ค๋ฉด C77.9(Lymph node, NOS), ์นจ๋ฒ”์ด ์—†๋‹ค๋ฉด C26.8(Overlapping lesion of digestive system)๋กœ ๋ถ€์—ฌํ•ฉ๋‹ˆ๋‹ค. ์กฐ์งํ•™์ ์ง„๋‹จ๋ช…์€ ๋†’์€ ์ฝ”๋“œ์ธ M9699/3 (Marginal zone B-cell lymphoma, NOS) ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
<< Diagnosis >>. Stomach, GC of lower body, biopsy:Neuroendocrine tumor (* see comment).a) size: 0.3x0.3cmb) depth of invasion: mucosac) mitosis: 1/10HPFd) lymphovascular invasion: absente) resected margin cannot be assessed due to tangential sectioning.ํ•ด๋‹น ์†Œ๊ฒฌ์œผ๋กœ C16 + 8240/3 ์„ ๋ถ€์—ฌํ•˜๋ ค๊ณ  ํ•˜์˜€์œผ๋‚˜ ์ฃผ์น˜์˜๊ฐ€ ํ†ต์ƒ์ ์ธ ์œ„์•”๊ณผ๋Š” ๋‹ค๋ฅด๋‹ค๊ณ  C269 ๋กœ ๋ถ€์—ฌํ•˜์˜€๋Š”๋ฐ C269 + 8240/3 ์œผ๋กœ ๋“ฑ๋กํ•ด๋„ ๋ ๊นŒ์š”?
*see note ์˜ ๋‚ด์šฉ์„ ๋ณด์ถฉํ•˜์—ฌ ์žฌ์งˆ์˜ ํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.(์ฃผ์น˜์˜๊ฐ€ ํ†ต์ƒ์ ์ธ ์œ„์•”๊ณผ ๋‹ค๋ฅด๊ฒŒ ๋ณด์‹  ๊ทผ๊ฑฐ๊ฐ€ ์žˆ๋‹ค๋ฉด ํ•จ๊ป˜ ์ ์–ด์ฃผ์‹œ๊ธฐ๋ฐ”๋ž๋‹ˆ๋‹ค)
์ดˆ๊ธ‰์— ๋Œ€๊ธฐ์‹ ์ฒญ์ค‘์ด์—ฌ์„œ ์ค‘๊ธ‰ ์‹ ์ฒญ์„ ๋ชปํ–ˆ๋Š”๋ฐ๋Œ€๊ธฐ๊ฐ€ ๋˜์„œ ์ดˆ๊ธ‰๊ต์œก์„ ๋ฐ›์•˜์Šต๋‹ˆ๋‹ค.ํ˜น์‹œ ์ค‘๊ธ‰๊ต์œก์— ์ž๋ฆฌ๊ฐ€ ์žˆ๋‹ค๋ฉด ์ถ”๊ฐ€ ์‹ ์ฒญ ๊ฐ€๋Šฅ์—ฌ๋ถ€ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
๊ต์œก์‹ ์ฒญ๊ธฐ๊ฐ„(2024.3.13~3.15) ์ด์™ธ์—๋Š” ์ทจ์†Œ์ž๊ฐ€ ๋ฐœ์ƒํ•˜๋”๋ผ๋„ ์ถ”๊ฐ€ ์‹ ์ฒญ์€ ์–ด๋ ต์Šต๋‹ˆ๋‹ค.
๋ณ‘๋ฆฌ์กฐ์ง ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ๊ฐ€ ์ด๋ ‡๊ฒŒ ๋‚˜์™”๋Š”๋ฐ,Colon, AV 4cm, EMR:Tubular adenoma with high grade dysplasia, carcinomatous glandsin mucosal portion,Consistent with INTRAMUCOSAL ADENOCARCINOMA,with clear resection margin(* Resected margin involvement: absent)M์ฝ”๋“œ, SEER ์ฝ”๋“œ, ๋ถ„ํ™”๋„๊ฐ€ ์–ด๋–ป๊ฒŒ ๋ ๊นŒ์š” ,,, ? ๊ทธ๋ฆฌ๊ณ  Colon, AV ๋ฉด ์›๋ฐœ๋ถ€์œ„ ์ฝ”๋“œ๊ฐ€ C19.9 ์ง์žฅ๊ตฌ๋ถˆ๊ฒฐ์žฅ ์ ‘ํ•ฉ๋ถ€๋กœ ์ค˜์•ผ ํ•˜๋‚˜์š”?
1) Mcode: M8140/2 , SEER: 1 , ๋ถ„ํ™”๋„: ๋นˆ์นธ ์œผ๋กœ ๋ถ€์—ฌํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.2) ์›๋ฐœ๋ถ€์œ„๋Š” ์˜์ƒ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ๋ฅผ ํ™•์ธํ•˜์—ฌ ๋ถ€์—ฌํ•ด์ฃผ์‹œ๊ธฐ๋ฐ”๋ž๋‹ˆ๋‹ค.[์ฐธ๊ณ ] ์•”๋“ฑ๋ก์ง€์นจ ๋ณ€๊ฒฝ ๋ฐ ์ฃผ์š”์‚ฌํ•ญ ๊ณต์ง€(2014) - "4) Intramucosal carcinoma"
right cheek, temple and left forehead, cheek์— ์ข…๊ดด๊ฐ€ ์žˆ์–ด์„œ ์ˆ˜์ˆ ํ•จ.โ€ป์ˆ˜์ˆ ์ „ ๊ฒ€์‚ฌSkin, cheek, right, punch biopsy:Atypical squamous epithelial lesion(see comments)โ€ป์ˆ˜์ˆ  biopsySkin, face, excision:1. SQUAMOUS CELL CARCINOMA IN SITU(A, "right temple")with 1) Tumor size: 1.3 x 0.5 cm 2) Resection margins: Free of carcinoma in situ (Safety margin: 12h: 0.2 cm, 6h: 0.3 cm, 3h: 0.2 cm, 9h: 0.2 cm, deep: 0.3 cm)2. INVASIVE SQUAMOUS CELL CARCINOMA(B, "left forehead")with 1) Tumor size: 0.8 x 0.6 x 0.15 cm 2) Invasion depth: 0.05 cm 3) No lymphovascular invasion 4) Resection margin: Free of carcinoma (Safety margin: lateral: 0.1 cm, deep: 0.1 cm)3. Actinic keratosis with focally involvement of resection margin(A, "right temple"; B, "left forehead"; C, "left cheek")Skin, cheek, right, wide excision:SQUAMOUS CELL CARCINOMA, MODERATELY DIFFERENTIATED(A, "right cheek"; B, "right cheek")with 1) Size: 1.7 x 1.3 cmใ€€ใ€€ 2) Depth of invasion: 0.5 cmใ€€ใ€€ 3) Lymphovascular invasion: Not identifiedใ€€ใ€€ 4) Resection margin: Free from carcinomaโ€ป๋ฌธ์˜์‚ฌํ•ญ1. c443์œผ๋กœ ์•”๋“ฑ๋ก์€ ํ•˜๋‚˜๋งŒ ํ•˜๋ฉด๋ ๊นŒ์š”? 2. seer๋Š” ์–ด๋–ค๊ฑธ ์ค˜์•ผ๋ ๊นŒ์š”?3. M์ฝ”๋“œ๋Š” ์–ด๋–ค๊ฑธ ์ค˜์•ผ๋ ๊นŒ์š”?
C44.3, M8070/3, SEER1๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
๋‚œ์†Œ์— ์•„๋ž˜์™€ ๊ฐ™์ด ์กฐ์ง๋ณ‘๋ฆฌ ๊ฒฐ๊ณผ ๋‚˜์˜จ ๊ฒฝ์šฐ ์•”๋“ฑ๋ก ์œ ๋ฌด์— ๋Œ€ํ•ด ๋ฌธ์˜ํ•ฉ๋‹ˆ๋‹ค.Diagnosis:Mucinous borderline tumor with intraepithelial carcinoma(focal), at left ovary์ด๋ ‡๊ฒŒ ๊ฒฐ๊ณผ๊ฐ€ ๋‚˜์˜ค๋ฉด ์•”๋“ฑ๋ก์€ ํ•ด์•ผ ํ• ๊ฑฐ ๊ฐ™์€๋ฐ ์ •์ƒ์†Œ์žฌ๋กœ ๋ณด๊ณ  ๋“ฑ๋กํ•˜๋ฉด ๋ ๋Ÿฐ์ง€์š”?๋ฐ”์˜์‹œ๊ฒ ์ง€๋งŒ ๋‹ต๋ณ€ ๋ฐ”๋ž๋‹ˆ๋‹ค.
M8010/2 Intraepithelial carcinoma, NOS๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
ํƒ€๋ณ‘์› ๊ธฐ๋ก 2023 ์•” ์ง„๋‹จ์‚ฐ์ •ํŠน๋ก€ 2023/10/06 ์— ์‹œ์ž‘์ด๋Ÿด ๊ฒฝ์šฐ ์ดˆ์ง„์—ฐ์›”์ผ์€ "2023","20231006"์ค‘ ์–ด๋Š ๊ฒƒ์œผ๋กœ ๋ถ€์—ฌํ•˜๋Š” ๊ฒŒ ์ข‹์„๊นŒ์š”?
๊ด€๋ฆฌ์ž ๋‹ต๋ณ€ ์—†์Œ
! ํ•ญ์ƒ ์ˆ˜๊ณ ๊ฐ€ ๋งŽ์œผ์‹ญ๋‹ˆ๋‹ค. ์•„๋ž˜ ํ์•” ๋ชฐํด๋กœ์ง€ ๊ด€๋ จ ์งˆ๋ฌธ์ž…๋‹ˆ๋‹ค.Lung, (left upper lobe), TBLB :Poorly differentiated carcinoma with small cell carcinoma like feature(SEE NOTE)(NOTE) Histology๋ฅผ ๊ณ ๋ คํ•˜๋ฉด neuroendocrine carcinoma ํŠนํžˆ small cell carcinoma์˜ ๊ฐ€๋Šฅ์„ฑ์ด ๋†’์œผ๋‚˜ ๋ฉด์—ญ์—ผ์ƒ‰ ๊ฒฐ๊ณผ๊ฐ€ ์ƒ์ ์ธ small cell carcinoma์— ํ•ฉ๋‹นํ•˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค. Ki-67์€ ๋งค์šฐ ๋†’์€ ์ข…์–‘์œผ๋กœ high grade ์ข…์–‘์œผ๋กœ ํŒ๋‹จ๋ฉ๋‹ˆ๋‹ค. Clinical correlation์ด ์š”๋ง๋ฉ๋‹ˆ๋‹ค.Ki-67: positive in 95%----------------------------------- ์ด ๊ฒฝ์šฐ M8020/3 ์™€ M8041/3 ์ค‘ Small cell carcinoma์— ํ•ฉ๋‹นํ•˜์ง€ ์•Š๋‹ค๊ณ ๊ธฐ์žฌ๋˜์–ด ์žˆ์–ด ํ•ด๋‹น ์ผ€์ด์Šค๋Š” ์–ด๋–ค ๋ชฐํด๋กœ์ง€๋ฅผ ๋ถ€์—ฌํ•ด์•ผ ํ•˜๋Š”์ง€,Mixed small cell carcinoma, M8045/3 ์œผ๋กœ ์จ๋„ ๋ ์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค.๋‹ต๋ณ€ ์ฃผ์‹œ๋ฉด ๊ฐ์‚ฌํ•˜๊ฒ ์Šต๋‹ˆ๋‹ค.
์ฃผ์น˜์˜ ์˜๊ฒฌ(์ž„์ƒ์†Œ๊ฒฌ) ํ™•์ธ์ด ์šฐ์„ ์ ์œผ๋กœ ํ•„์š”ํ•˜์ง€๋งŒ ํ™•์ธ์ด ๋ถˆ๊ฐ€ํ•˜๋‹ค๋ฉด M8020/3 Carcinoma, undifferentiated, NOS๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
์•”๋“ฑ๋ก ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ์กฐ์ง๊ฒ€์‚ฌ ์ƒ ๋‹ค์Œ๊ณผ ๊ฐ™์ด ํŒ๋… ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.[DIAGNOSIS] ย SPECIMENย Submitted:ย distalย gastrectomy,ย unfixed Gross : Measurement(cm):ย GCย (22.5),ย LCย (18.5),ย PRMย (8.0),ย DRMย (5.0),ย Dย (1.0) Tumorย location:ย Lย 1/3,ย LCย  Fromย PRMย (6.5),ย DRMย (3.5) Tumorย size:ย (5.8x5.2)ย cm Tumorย typeย Advancedย (Borrmannย type):ย IIIย Blockedย inย forย mapping:ย A1-4ย (tumorย 1),ย A5-6ย (tumorย 2),ย B1(proximalย resectionย margin),ย ย ย  B2(distalย resectionย margin),ย C(SMT),ย N1(#1),ย N2-3(#3),ย N4(#4),ย ย ย  N5(#5),ย N6-7(#6),ย N8(#7),ย N9(#8)ย Microscopic:Classification:ย Epithelialย carcinoma:ย Adenocarcinomaย -ย tub(mod)ย Depthย ofย tumorย invasion:ย ssย pT3ย Depthย ofย ulcer:ย mย Resectionย margin:ย prmย (-),ย drmย (-)Laurenย classification:ย intestinalGrowthย patterns(Ming):ย expandingย Lymphoidย reaction:ย mildLymphaticย /ย Venousย invasion:ย severeย Nerveย invasion:ย noย Non-neoplasticย stomachย (withinย 2ย cmย fromย tumor)Chronicย atrophicย gastritis:ย mildย Intestinalย metaplasia:ย moderateย Dysplasia:ย highย gradeย H.ย pylori:ย noย Polyp(s):ย noย Lymphย nodeย metastasis:ย (pN3ย :ย โ†‘7),ย ย ย 1(0/8),ย 3(5/20),ย 4(0/10),ย 5(0/0),ย 6(2/6),ย 7(1/3),ย 8(0/11)ย Immunohistochemistryย andย Specialย stain:MLH-1ย (postive,ย notย mutated),ย MSH-2ย (positive,ย not-mutated),ย CerbB-2ย (positive,ย 2+),ย CD34ย (+,ย bloodย vessel),ย D2-40ย (+,ย lymphaticย vessel):ย distalย sideย ulcerofungatingย massย ย CD34ย (+),ย S-100ย (-),ย SMAย (-),ย CD117ย (+)ย :ย proximalย sideย ofย AWย ์˜ย submucosalย tumorย DIAGNOSIS:ย ย ย Stomach,ย distalย side,ย distalย gastrectomy:ย Adenocarcinoma,ย moderatelyย differentiatedย ย ย Lymphย node,ย dissection:ย Metastaticย adenocarcinomaย (8/58)ย Stomach,ย proximalย sideย ofย AW,ย wedgeย resection:ย Gastrointestinalย stromalย tumor์œ„์˜ ๊ฒฝ์šฐ1) ๋ชจํด๋กœ์ง€๋ฅผ ๊ฐ๊ฐ ๋ถ€์—ฌํ•˜์—ฌ์•ผ ํ•˜๋Š”์ง€ ์•„๋‹ˆ๋ฉด ํ•˜๋‚˜๋งŒ ๋ถ€์—ฌํ•˜์—ฌ์•ผ ํ•˜๋Š”์ง€ ( ํ•˜๋‚˜๋งŒ ๋ถ€์—ฌํ•œ๋‹ค๋ฉด ์–ด๋–ค ๋ชจํด๋กœ์ง€ ์ฝ”๋“œ๋ฅผ ๋ถ€์—ฌํ•˜์—ฌ์•ผ ํ•˜๋Š”์ง€)1) ๋ชจํด๋กœ์ง€๋ฅผ ๊ฐ๊ฐ ๋ถ€์—ฌํ•˜์—ฌ์•ผ ํ•œ๋‹ค๋ฉด C16.- ์ฝ”๋“œ๋„ ๊ฐ๊ฐ€ ๋ถ€์—ฌํ•˜์—ฌ์•ผ ํ•˜๋Š”์ง€ ์•„๋‹ˆ๋ฉด ํ•˜๋‚˜๋งŒ ๋ถ€์—ฌํ•˜์—ฌ์•ผ ํ•˜๋Š”์ง€ ( ํ•˜๋‚˜๋งŒ ๋ถ€์—ฌํ•œ๋‹ค๋ฉด ์–ด๋–ค ์ฝ”๋“œ๋ฅผ ๋ถ€์—ฌํ•˜์—ฌ์•ผ ํ•˜๋Š”์ง€)๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค
mass๊ฐ€ 2๊ฐœ๋ผ๋ฉด M8211/3 Tubular adenocarcinoma, M8936/3 Gastrointestinal stromal tumor๋กœ ๊ฐ๊ฐ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.mass๊ฐ€ 1๊ฐœ๋ผ๋ฉด ""2012 ์•”๋“ฑ๋ก์ง€์นจ- P.44 ๋ณต์žกํ•œ ์กฐ์งํ•™์  ์ง„๋‹จ๋ช… ๊ทœ์น™""์„ ๊ธฐ์ค€์œผ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
. seer ์ฝ”๋“œ์™€ m์ฝ”๋“œ ๊ด€๋ จํ•˜์—ฌ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. 1. C18._ ์›๋ฐœ๋ถ€์œ„์ผ ๊ฒฝ์šฐ, peritoneum seeding ์ธ ๊ฒฝ์šฐ์—retroperitoneum ์œผ๋กœ ๋ณด๊ณ  seer 2 ๋กœ ๋ถ€์—ฌํ•˜๋ฉด ๋˜๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. 2. brain, Rt frontal lobe, open biopsy: DIFFUSE HEMISPHERIC GLIOMA, H3 D34-MUTANT, WHO GRADE 4, with 1) histological diagnosis: high grade nueroepithelial tumor์ผ ๋•Œ, m์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. 3. Uterus, radical hysterectomy: Squamous cell carcinoma, HPV-associated, with neuroendocrine and sarcomatoid differentiation ์œผ๋กœ ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ ๋‚˜์˜จ๊ฒฝ์šฐ, hpv + ๊ฒฐ๊ณผ์— ๋”ฐ๋ผ M8085/3 ์œผ๋กœ ์ฃผ๋ฉด ๋˜๋Š”์ง€, ๋‹ค๋ฅธ ์ฝ”๋“œ ๋ถ€์—ฌํ•ด์•ผํ•˜๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ** ์„ธ ์งˆ๋ฌธ์— ๋Œ€ํ•œ ์ผ€์ด์Šค๋Š” ๋ณ„๊ฐœ์ž…๋‹ˆ๋‹ค.
1. peritoneum seeding์€ ๋ถ€์œ„์— ์ƒ๊ด€์—†์ด SEER 7๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.2. M9380/3 Glioma, NOS(C71._)(except nasal glioma: not neoplastic)๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.3. M8085/3 Squamous cell carcinoma, HPV positive๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
.์›๋ฐœ๋ถ€์œ„, SEER ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.*Tonsil, punch biopsy(20240119):Atypical T-cell proliferative lesion , consistent with T-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA*BM biopsy(20240130) :T-lymphoblastic leukemia*Chest CT(20240131) ; 1. Multiple enlarged LNS in both axilla, supraclavicular area, lower neck , mediastinum and cardiophernic angle- lymphoproliferative disease2. A tiny nodule in RUL posterior segment - benign inflammatory nodule, more likely 3. Emphysema in subcutaneous layer of chest wall -procedure related change 4. Scanned upper abdomen : hepatosplenometgaly*Abd& pelvis CT (20240215) ;- Mild edematous wall thickening of rectosigmoid colon ; r/o proctocolitis- F/U for T cell lymphoblastic disorder ; interval decrease in size of nummerous enlarged LNs involving whole abdominal lymphatic chain(Lt. anterior CPA, both retrocrural, celiac, mesenteric, gastroduodenal lig, portocaval, retrocaval, aortocaval, paraaortic, both CIA, EIA, IIA area), but still significantly remained ; interval decrease in size of spleen - Improvement of periportal edema - Small amount of pelvic ascites- Otherwise, nonspecific abdomen๊ฒ€์‚ฌ๊ฒฐ๊ณผ ์œ„์™€๊ฐ™์ด T-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA ์ง„๋‹จ๋œ ๋ถ„์œผ๋กœ ์›๋ฐœ๋ถ€์œ„ ๋ฐ SEER ํ™•์ธ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค!
C42.1, SEER 7๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
์„ ์ƒ๋‹˜ . C19(RS-Colon)์™€ C20(Rectum)์ชฝ ๋™์‹œ์— ์•”์ด ๋ฐœ๊ฒฌ๋œ ์ผ€์ด์Šค๋กœC19์™€ C20๋Š” ๋™์ผ๋ฒ”์ฃผ์ด๊ธฐ ๋•Œ๋ฌธ์— C20์œผ๋กœ ์•”๋“ฑ๋กํ•˜๋Š” ๊ฒƒ์œผ๋กœ ์•Œ๊ณ  ์žˆ์œผ๋‚˜,ํ•ด๋‹น ์ผ€์ด์Šค์˜ ๊ฒฝ์šฐ RS์ชฝ TNM์ด ๋” ๋†’๊ฒŒ ๋‚˜์™”๊ธฐ ๋•Œ๋ฌธ์— ์ด๋Ÿฌํ•œ ๊ฒฝ์šฐ์—๋Š” ์•”์ฝ”๋“œ์™€ TNM์„ ์–ด๋–ป๊ฒŒ ๋ถ€์—ฌํ•˜๋ฉด ์ข‹์„์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋Š” ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค.๋ณ‘๋ฆฌ 1) #2. Rectum, Polyp, Is, Endoscopic mucosal resection:Adenocarcinoma, well differentiated 16) Pathologic stage (AJCC 2018): pT1๋ณ‘๋ฆฌ 2) DIAGNOSIS:Colon, rectosigmoid, low anterior resection: Adenocarcinoma, moderately differentiated 17) Pathologic stage (AJCC 2018): pT3N0 ๋ฐ”์˜์‹  ์ค‘์— ์˜๊ฒฌ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค :)
C20.9, M8140/3, T3N0๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
craniotomy ํ›„, ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ ๋‹ค์Œ๊ณผ ๊ฐ™์Šต๋‹ˆ๋‹ค.Brain, craniotomy and biopsy: MENINGIOMA, PSAMMOMATOUS and MENINGOTHELIAL TYPES, WHO GRADE 2 (2021 WHO classification)์ด ๊ฒฝ์šฐ์—๋Š” Psammomatous meningioma (M9553/0), Meningothelial meningioma (M9531/0), Mixed meningioma(M9537/0) ์ค‘์— ์–ด๋–ค ๊ฒƒ์œผ๋กœ ๋ณด๋Š” ๊ฒƒ์ด ๋งž์„์ง€ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
M9533/0 Psammomatous meningioma๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.(์ฐธ๊ณ ) 2012 ์•”๋“ฑ๋ก์ง€์นจ- P.44 ๋ณต์žกํ•œ ์กฐ์งํ•™์  ์ง„๋‹จ๋ช… ๊ทœ์น™- 4. ๋†’์€ ์ฝ”๋“œ๋ฒˆํ˜ธ๋กœ ์ฝ”๋”ฉ
M์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. [Additional Diagnosis] 2023.9.26. By Choi,KUOvary, left, cystectomy: 1. Histologic type: Clear cell carcinoma associated with seromucinous borderline tumor and endometriosis 2. Tumor side: Left 3. Tumor size: 7.5x3.5x0.6cm 4. Histologic grade 2/3 Predominantly papillary and tubular growth pattern Marked nuclear atypia Mitosis : 2/10HPFs 5. Extent of tumor: Not applicable 6. Lymphovascular invasion : Not identified.#Immunohistochemistry [1-1] PAX8: diffuse positive ER,PR: positive for seromucinous area p53: focal positive WT1,napsin A: negative CD10: positive for stroma[Previous Diagnosis] 2023.9.19.Ovary, left, cystectomy: MIXED CARCINOMA with - mixed seromucinous and clear cell type - endometriosis-associated stroma์ผ๋•Œ M8310/3 ์œผ๋กœ ์ฃผ๋ฉด ๋˜๋Š”์ง€ ์•„๋‹ˆ๋ฉด /1 ๋กœ ์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ์•„๋‹Œ๊ฑด์ง€ ํ™•์ธ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
์ตœ์ข…์ง„๋‹จ์ด 'Clear cell carcinoma associated with seromucinous borderline tumor and endometriosis'๊ฐ€ ๋งž๋‹ค๋ฉด M8310/3์œผ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
CT ๊ฒ€์‚ฌ๊ฒฐ๊ณผ๋Š” ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค..CT,Pancreas : Borderline resectable pancreatic tail cancer. - abutment of celiac axis. - invasion of left renal artery and renal vein. - invasion of left adrenal gland & left diaphragm..์˜์‚ฌ๊ธฐ๋ก: Pancreas cancer with R/O celiac axis invasionPancreas tail ๋ถ€์œ„ cancerํ™˜์ž์ž…๋‹ˆ๋‹ค.SEER์ฑ…์ž 112ํŽ˜์ด์ง€๋ฅผ ๋ณด๋ฉด SEER 7์˜ Extension to์•„๋ž˜Body and/or tail of pancreas๋ถ€๋ถ„์—Adrenal gland๊ฐ€ ์–ธ๊ธ‰๋˜์–ด์žˆ์Šต๋‹ˆ๋‹ค.1.์œ„๊ณผ ๊ฐ™์ด ์˜์ƒ๊ฒ€์‚ฌ์—์„œ adrenal gland invasion์ด ์žˆ๋Š” ๊ฒฝ์šฐ Extension to์™€ ๊ฐ™์ด ๋ณด๊ณ  SEER 7๋กœ ๋ถ€์—ฌํ•˜๋ฉด ๋˜๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.2.๋”๋ถˆ์–ด adrenal gland์— ๋Œ€ํ•ด ์˜์‚ฌ์–ธ๊ธ‰์ด ์—†์–ด๋„ ์˜์ƒ๊ฒ€์‚ฌ์—์„œ ์œ„์™€ ๊ฐ™์ด ์–ธ๊ธ‰๋˜๋Š” ๊ฒฝ์šฐ SEER์— ๋ฐ˜์˜ํ•  ์ˆ˜ ์žˆ๋Š”์ง€๋„ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค
์˜์‚ฌ ์–ธ๊ธ‰์ด ์—†๋”๋ผ๋„ ์˜์ƒ ๊ฒ€์‚ฌ์—์„œ distant metastasis๊ฐ€ ํ™•์ธ๋˜์—ˆ์œผ๋ฏ€๋กœ SEER 7๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
Lung aspiration๊ฒฐ๊ณผ์ž…๋‹ˆ๋‹ค.Lung,(right lower lobe), EBUS-TBNA: -SQUAMOUS CELL CARCINOMA, MD CT ๊ฒ€์‚ฌ๊ฒฐ๊ณผ์ž…๋‹ˆ๋‹ค.CT, Chest:About 4.5cm sized mass lesion in RLL, central portion. Combined with obstructive pneumonia in RLL. Enlarged LNs in Rt.upper/lower paratracheal, subcarinal and Rt.hilar/interlobar areas.RLL๋ถ€์œ„์— Lung cancer์žˆ๋Š” ํ™˜์ž์ž…๋‹ˆ๋‹ค.1. CT์˜์ƒ๊ฒ€์‚ฌ์—์„œ RLL๋ถ€์œ„์— obstructive pneumonia ๊ฐ€ ์žˆ์œผ๋ฉฐ, ์˜์‚ฌ๊ธฐ๋ก์—๋Š” obstructive pneumonia ์— ๋Œ€ํ•ด ๋ณ„๋„๋กœ ์–ธ๊ธ‰์ด ์—†์Šต๋‹ˆ๋‹ค. ์ด๋Ÿฐ ๊ฒฝ์šฐ์— obstructive pneumonia ๋ฅผ ๋ฐ˜์˜ํ•˜์—ฌ 'SEER 2'๋ฅผ ๋ถ€์—ฌํ•  ์ˆ˜ ์žˆ๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.2. ๊ทธ๋ฆฌ๊ณ , obstructive pneumonia ๊ฐ€ Lung cancer๋ถ€์œ„์ธ RLL์— ์žˆ์ง€์•Š๊ณ ,๋‹ค๋ฅธ ํ๋ถ€๋ถ„์— ์žˆ๋Š” ๊ฒฝ์šฐ์—๋„ ์˜์ƒ๊ฒ€์‚ฌ์—์„œ ์–ธ๊ธ‰๋˜๋ฉด 'SEER 2'๋กœ ๋ฐ˜์˜ํ•  ์ˆ˜ ์žˆ๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
1. SEER 4๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.(์ฐธ๊ณ ) SEER Summary Staging Manual 2000 - p7 Regional Lymph Node Involvement - 4๋ฒˆ2. ์›๋ฐœ๋ถ€์œ„๊ฐ€ ์•„๋‹Œ lobe์— obstructive pneumonia(or atelectasis)๊ฐ€ ์žˆ๋Š” ๊ฒฝ์šฐ๋Š” SEER 2์— ํ•ด๋‹นํ•˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค.
? ๋ฐ”์˜์‹œ๊ฒ ์ง€๋งŒ ๋ถ„ํ™”๋„ ์งˆ๋ฌธ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.1. Carcinoma, undifferentiated, NOS2. Carcinoma, poorly differentiated, NOS3. Anaplastic undifferentiated carcinoma4. Dedifferentiated carcinoma5. Poorly diffirentiated carcinoma6. Carcinoma, differentiatedํ•ด๋‹น Morphology ๋ชจ๋‘ ICD-O-3 2nd revision์— ๋”ฐ๋ผ M8020/3 ์œผ๋กœ ๋“ฑ๋กํ•˜๊ณ ,๋ถ„ํ™”๋„๋Š” 2021๋…„๋„ ๋ณ„์ฒจ8. ์•”๋“ฑ๋ก ๊ฐœ์ •์‚ฌํ•ญ์— ๋”ฐ๋ผ์„œ "4"๋กœ ์ž…๋ ฅ๋˜์–ด์•ผ ํ•˜๋Š”๋ฐMBW๋กœ ๋งคํฌ๋กœ ์˜ค๋ฅ˜๊ฐ€ ๊ฑธ๋ ค์„œ ์งˆ๋ฌธ์„ ์—ด์‹ฌํžˆ ๋ณด๊ณ  ์ •๋ฆฌํ•ด๋ดค์Šต๋‹ˆ๋‹ค.์ตœํฌ ์„ ์ƒ๋‹˜ ์งˆ๋ฌธ์—์„œ๋Š” carcinoma, poorly diffirentiated์—์„œ๋Š” ๋ณ„์ฒจ8์„ ์šฐ์„  ์ ์šฉํ•˜์—ฌ 4๋ฒˆ [โ€ป์งˆ์˜๋ฅผ undiffirentiated๋กœ ์˜ฌ๋ ค์ฃผ์ง€ ์•Š์œผ์…จ์Šต๋‹ˆ๋‹ค]์ด๊ณ ์€/์ด์ง€์˜ ์„ ์ƒ๋‹˜ ๋‹ต๋ณ€์—์„œ๋Š” 5๋ฒˆ. Poorly diffirentiated carcinoma ๋Š” ๋ถ„ํ™”๋„ 3๋ฒˆ๊น€๋ฏผํฌ ์„ ์ƒ๋‹˜ ๋‹ต๋ณ€์—์„œ๋Š”, [์กฐ์งํ•™์  ์ง„๋‹จ๋ช…์— ๋ถ„ํ™”๋„๊ฐ€ ๋ช…์‹œ๋œ ๊ฒฝ์šฐ์—๋Š” ์กฐ์งํ•™์  ์ง„๋‹จ๋ช…์— ๋ถ„๋ฅ˜๋œ ๋ถ„ํ™”๋„๋กœ ๋“ฑ๋กํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค]๋กœ ๋‹ต๋ณ€ํ•ด์ฃผ์…จ์Šต๋‹ˆ๋‹ค.-ํ•˜๊ธฐ์™€ ๊ฐ™์ด ๋‹ต๋ณ€์„ ์ •๋ฆฌํ•ด๋ณด์ž๋ฉด 1. Carcinoma, Undifferentiated, NOS ๋ถ„ํ™”๋„ -4 "๊ฐœ์ •์ง€์นจ ๋ณ„์ฒจ.8 ์ ์šฉ"2. Carcinoma, poorly differentiated, NOS ๋ถ„ํ™”๋„ - 3 or 4 "๊น€๋ฏผํฌ/์ตœํฌ ์„ ์ƒ๋‹˜ ๋‹ต๋ณ€์ ์šฉ"3. Anaplastic undifferentiated carcinoma ๋ถ„ํ™”๋„ -4 "๊ฐœ์ •์ง€์นจ ๋ณ„์ฒจ.8 ์ ์šฉ"4. Dedifferentiated carcinoma ๋ถ„ํ™”๋„ -4 "๊ฐœ์ •์ง€์นจ ๋ณ„์ฒจ.8 ์ ์šฉ"5. Poorly diffirentiated carcinoma ๋ถ„ํ™”๋„ -3 "์ด๊ณ ์€/์ด์ง€์˜ ์„ ์ƒ๋‹˜ ๋‹ต๋ณ€์ ์šฉ"6. Carcinoma, differentiated "๊ฐœ์ •์ง€์นจ ๋ณ„์ฒจ.8 ์ ์šฉ"Carcinoma, poorly differentiated์™€ Poorly diffirentiated carcinoma ๋งŒ ๋ถ„ํ™”๋„ 3์œผ๋กœ ์ž…๋ ฅํ•˜๋ฉด ๋˜๋Š”๊ฑด๊ฐ€์š” ?
๋ถ„ํ™”๋„ 3์œผ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
์ˆ˜๊ณ ๋งŽ์œผ์‹ญ๋‹ˆ๋‹ค. ๊ฐ„์™ธ๋‹ด๋„์•” M์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. 1) ์กฐ์ง๊ฒ€์‚ฌ ๊ฒฐ๊ณผ๋Š” ์•„๋ž˜์™€ ๊ฐ™๊ณ  Bile duct, common hepatic duct, endoscopic biopsy: Adenocarcinoma, well differentiated ์ฃผ์น˜์˜๋Š” CHD Ca ์™€ hilar Ca๋ฅผ ํ˜ผ์šฉํ•˜์—ฌ ์ตœ์ข…์ง„๋‹จํ•˜์…จ์Šต๋‹ˆ๋‹ค. ๊ทธ๋ž˜์„œ ์ •ํ™•ํ•œ ์œ„์น˜๋ฅผ ํ™•์ธํ•˜๊ณ ์ž ์˜์ƒ์„ ์ฐธ๊ณ ํ•˜์˜€๋Š”๋ฐ APCT์—์„œ๋Š” ๋ช…ํ™•ํ•˜๊ฒŒ Klatskin tumor, Bismuth type IV ์ž…๋‹ˆ๋‹ค. Q. ์ฃผ์น˜์˜๋Š” ์›๋ฐœ๋ถ€์œ„๋ฅผ Klatskin tumor๋ผ๊ณ  ๋ช…์‹œํ•˜์ง€ ์•Š์œผ์…จ์ง€๋งŒ ์˜์ƒํ•™์ ์œผ๋กœ Klatskin tumor ๋ผ๊ณ  ํŒ๋…์ด ๋˜์–ด์žˆ์œผ๋ฉด ์˜์ƒ๊ฒ€์‚ฌ๋ฅผ ์ฐธ๊ณ ํ•˜์—ฌ M์ฝ”๋“œ๋ฅผ M8162/3์œผ๋กœ ๋“ฑ๋ก ๊ฐ€๋Šฅํ• ๊นŒ์š” ? ํ˜น์€ ์ง€์นจ๋Œ€๋กœ ์ž„์ƒ๊ฒ€์‚ฌ ๋ณด๋‹ค ์›๋ฐœ๋ถ€์œ„์˜ ์กฐ์ง๊ฒ€์‚ฌ๋ฅผ ๋” ์šฐ์„ ์‹œ ํ•˜์—ฌ ์ฃผ์น˜์˜๋Š” Klatskin tumor๋ผ๊ณ  ๋ช…์‹œํ•˜์ง€ ์•Š์•˜์œผ๋‹ˆ M8160/3 ๋“ฑ๋ก์„ ํ•ด์•ผํ•˜๋‚˜์š” ?๋น ๋ฅธ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ^^
M8162/3, ์ง„๋‹จ๋ฐฉ๋ฒ• 7๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.(์ฐธ๊ณ ) ์•”๋“ฑ๋ก์ง€์นจ ๋ณ€๊ฒฝ ๋ฐ ์ฃผ์š”์‚ฌํ•ญ ๊ณต์ง€(2018) - "(2) Klatskin tumor(M8162/3) ์ฝ”๋”ฉ ์‹œ ์ฃผ์˜์ "
. ๊ณ ์ƒ ๋งŽ์œผ์‹ญ๋‹ˆ๋‹ค ๋‹ด๋‹น์ž๋‹˜!ํ™˜์ž๋ถ„์ด ํƒ€๋ณ‘์›์—์„œ ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ๋กœ2023-12-01Colon, descending, endoscopic polypectomy: Tubular adenoma, low grade with clear resection margin ๊ฐ€ ๋‚˜์™”์Šต๋‹ˆ๋‹ค. ์ดํ›„ ์ €ํฌ ๋ณ‘์›์—์„œ์˜ ์ถ”๊ฐ€ ์ง„๋‹จ(์™ธ๋ถ€์กฐ์ง๋ณ‘๋ฆฌ๊ฒ€์‚ฌ)์œผ๋กœ2024-01-19Colon, 60cm from anal verge, endoscopic polypectomy: Adenocarcinoma, well-differentiated, arising in tubulovillous adenoma,with 1)Kudo/Kikuchi classification of Malignant sessile polyp: invasion into upper 1/3 of submucosa ( SM1, 160 micrometer-depth of submucosal invasion) 2) cancer size : 3384 micrometer x 1610 micrometer in the largest dimension 3) resected margin involvement of the cancer : absent (safety margin : nearest, 2549 micrometer apart from basal deep resection) 4) resected margin involvement of the adenoma : undetermined 5) associated findings: tubulovillous adenoma 6) negative for lymphovascular tumor invasion์œ„์™€ ๊ฐ™์€ ๊ฒฐ๊ณผ๊ฐ€ ๋‚˜์™”์Šต๋‹ˆ๋‹ค.-------------------------------------------------------ํƒ€๋ณ‘์›์—์„œ polypectomy ์‹œํ–‰ ํ›„ ํŒ๋…์‹œ ์•…์„ฑ์ด ์•„๋‹ˆ์—ˆ์ง€๋งŒ ๋ณธ์›์—์„œ ์žฌํŒ๋… ํ›„ ์•…์„ฑ์œผ๋กœ ์ง„๋‹จ๋œ ๊ฒฝ์šฐ๋กœ ์›์น™๋Œ€๋กœ๋ผ๋ฉด ๋ณธ์› ์ฒซ ๋‚ด์›์ผ์ด ์ดˆ์ง„์ผ์ด ๋˜์ง€๋งŒ, polypectomy์˜ ๊ฒฝ์šฐ '์ˆ˜์ˆ '๋กœ ๋ณด๊ธฐ๋•Œ๋ฌธ์— ๋ณธ์› ๋‚ด์›์ผ์„ ์ดˆ์ง„์ผ๋กœ ์„ ์ •์‹œ ์ˆ˜์ˆ ์น˜๋ฃŒ์ž…๋ ฅ์ด ์–ด๋ ค์Šต๋‹ˆ๋‹ค.์ด๋Ÿฐ ๊ฒฝ์šฐ '์ดˆ์ง„๋…„์›”์ผ์ž / ์•”์ง„๋‹จ๊ฒฝ๋กœ / ์น˜๋ฃŒ๋ฐฉ๋ฒ•' '2023-12-01 / ํƒ€๋ณ‘์›์ง„๋‹จ/ ์ˆ˜์ˆ ' ๋กœ ๋ณด๋Š”๊ฒŒ ๋งž์„๊นŒ์š”?
์ˆ˜์ˆ  ํ›„ ์ž”์—ฌ์ข…์–‘์ด ์—†๋‹ค๋ฉด ์ˆ˜์ˆ ์น˜๋ฃŒ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
1. ์กฐ์ง๊ฒ€์‚ฌ ๊ฒฐ๊ณผ Common bile duct, endoscopic biopsy; No tumor present 2.์„ธํฌ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ์„ธ๋ถ€๊ฒ€์ฒด : bile brushing[DIAGNOSIS] 1) Adequacy of specimen Satisfactory 2) Cytologic diagnosis Malignancy์ด๋Ÿฌํ•œ ์ƒํ™ฉ์—์„œ ์ฃผ์น˜์˜๋Š” ์„ธํฌ๊ฒ€์‚ฌ๊ฒฐ๊ณผ๋ฅผ ํ† ๋Œ€๋กœ C240์œผ๋กœ ์ง„๋‹จํ•˜์˜€์Šต๋‹ˆ๋‹ค.์งˆ๋ฌธ1. ์„ธํฌ๊ฒ€์‚ฌ๊ฒฐ๊ณผ์—์„œ ๊ตฌ์ฒด์ ์ธ ๋ชฐํฌ๋กœ์ง€๊ฐ€ ์•ˆ๋‚˜์˜จ ๊ฒฝ์šฐ M8000/3์œผ๋กœ ํ•ด์•ผํ•˜๋Š”์ง€ ์•„๋‹ˆ๋ฉด M8160/3(Cholangiocarcinoma) ์œผ๋กœ ํ•ด์•ผํ•˜๋Š”์ง€์š”์งˆ๋ฌธ2. ์•”๋“ฑ๋ก์ง€์นจ์„œ์ƒ ๋น„ํ˜„๋ฏธ๊ฒฝ์  ๋ฐฉ๋ฒ•์œผ๋กœ ์ง„๋‹จ์‹œ ์ธ์ •๋˜๋Š” ์กฐ์งํ•™์  ์†Œ๊ฒฌ์ด ์žˆ๋Š”๋ฐ ์—ฌ๊ธฐ์— ์„ธํฌ๊ฒ€์‚ฌ(ํ˜„๋ฏธ๊ฒฝ์  ๋ฐฉ๋ฒ•)์œผ๋กœ ์ง„๋‹จ๋˜์—ˆ์œผ๋‚˜ ๊ตฌ์ฒด์ ์ธ ๋ชฐํฌ๋กœ์ง€๋ฅผ ์•Œ์ˆ˜ ์—†๋Š” ๊ฒฝ์šฐ๋„ ํฌํ•จ๋˜๋Š”๊ฑด์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
์กฐ์ง๊ฒ€์‚ฌ ๋ฐ ์„ธํฌ๊ฒ€์‚ฌ์˜ ๊ฒ€์‚ฌ์ผ์ž์™€ ๋‘ ๊ฒ€์‚ฌ ์‹œํ–‰ ๋ถ€์œ„๊ฐ€ ๋™์ผํ•œ์ง€ ๋“ฑ์˜ ์ถ”๊ฐ€์ •๋ณด๋ฅผ ๋ณด์ถฉํ•˜์—ฌ ์žฌ์งˆ์˜๋ฐ”๋ž๋‹ˆ๋‹ค.
์„ ์ƒ๋‹˜ . colon ์•”๋“ฑ๋ก ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋Š” ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค.1. Colon, proximal descending, endoscopic mucosal resection (#2):Adenocarcinoma, well differentiated 1) Histologic grade: low2) Tumor configuration: polypoid (sessile)3) Size of tumor: recorded "1.0x0.7cm (including adenoma)"4) Extent of invasion: mucosa (lamina propria)(pTis)2. Colon, distal sigmoid, endoscopic polypectomy (#4):Tubulovillous adenoma, high grade dysplasia๋ณ‘๋ฆฌ ์ƒ 1๋ฒˆ ๋ณ‘๋ฆฌ๋Š” C186 81402 SEER 1 / 2๋ฒˆ ๋ณ‘๋ฆฌ๋Š” C187 82632 SEER 0์ธ๋ฐ,ํ•ด๋‹น ๊ฒฝ์šฐ๋Š” ๋‹ค์ค‘์›๋ฐœ์•”์ด ์•„๋‹ˆ๋ผ ์•”์ฝ”๋“œ๋Š” C189 ๋ถ€์—ฌํ•œ ํ›„, ํ˜•ํƒœํ•™์ด๋ž‘ SEER๋Š” ์–ด๋–ป๊ฒŒ ๋ถ€์—ฌํ•˜๋ฉด ๋ ์ง€ ์˜๊ฒฌ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค :)
M8263/2 Adenocarcinoma in situ in tubulovillous adenoma, SEER 0์œผ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.(์ฐธ๊ณ ) 2012 ์•”๋“ฑ๋ก์ง€์นจ- P.44 ๋ณต์žกํ•œ ์กฐ์งํ•™์  ์ง„๋‹จ๋ช… ๊ทœ์น™- 4. ๋†’์€ ์ฝ”๋“œ๋ฒˆํ˜ธ๋กœ ์ฝ”๋”ฉ
์กฐ์ง๋ณ‘๋ฆฌ๊ฒฐ๊ณผ์ƒ ์•„๋ž˜์™€ ๊ฐ™์€ ๊ฒฐ๊ณผ์ž…๋‹ˆ๋‹ค.Cornea, left, excisional biopsy; Corneal intraepithelial neoplasia 3M8077/2๋กœ ๋ถ€์—ฌํ•ด๋„ ๋˜๋Š”์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค.
์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค.
์™ธ๋ž˜ 2/21 ๋ณ‘๋ฆฌ๊ฒ€์‚ฌํ•œ ๊ฒฐ๊ณผSkin, chin, left, excision:INVASIVE SQUAMOUS CELL CARCINOMA, keratoacanthomatous typewith 1) Tumor size: 1.5 cm in greatest dimension 2) Invasion depth: 0.4 cm ใ€€ใ€€ 3) Lymphovascular invasion: Not identified ใ€€ใ€€ 4) Resection margin: Clear resection margin, but very close to resection margin (safety margin: deep and lateral margins: <1.0 mm)์ž…์› ์ˆ˜์ˆ ํ•˜๋ฉด์„œ ๋ณ‘๋ฆฌ๊ฒ€์‚ฌํ•œ ๊ฒฐ๊ณผSkin, left chin, excision:1. Focal CARCINOMA IN SITU(Status post excision: S24-04146, Skin, left chin, Invasive squamous cell carcinoma) with 1) Tumor size: 0.8 x 0.7 x 0.1 cmใ€€ใ€€ใ€€2) No lymph nodesใ€€ใ€€ใ€€3) Resection margin: Free of carcinoma ใ€€ใ€€ใ€€(Safety margin: 12h: 0.4 cm, 3h: 0.7 cm, ใ€€ใ€€ใ€€6h: 0.4 cm, 9h: 0.9 cm)์˜์‚ฌ ์ž…ํ‡ด์›์š”์•ฝ ์ง„๋‹จ Squamous cell cancer, skin์ด ๊ฒฝ์šฐ์—๋Š” M์ฝ”๋“œ๊ฐ€ ์–ด๋–ค ๊ฒƒ์œผ๋กœ ํ•ด์•ผํ• ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. (1. ๋‹ค์ค‘์›๋ฐœ์•”์œผ๋กœ ํ•ด์•ผํ•˜๋Š”์ง€, 2. ์ˆ˜์ˆ  ์‹œ ์กฐ์งํ•™์ ์ง„๋‹จ๋ช…์œผ๋กœ ํ•ด์•ผํ•˜๋Š”์ง€, 3. ๋†’์€ ๋ฒˆํ˜ธ๋กœ ํ•ด์•ผํ•˜๋Š”์ง€, 4.์ฃผ์น˜์˜ ์ง„๋‹จ์„ ๋”ฐ๋ผ์•ผํ•˜๋Š”์ง€)์™ธ๋ž˜: INVASIVE SQUAMOUS CELL CARCINOMA, keratoacanthomatous type์ˆ˜์ˆ : Focal CARCINOMA IN SITU
M8070/3 Squamous cell carcinoma, NOS์œผ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
์›๋ฐœ๋ถ€์œ„๋Š” ์˜๋ฌด๊ธฐ๋ก ๊ฒฐ๊ณผ๋ณด๊ณ ์„œ ๋‚ด์šฉ ์ƒ์ถฉ์‹œ ๊ณ ๋ ค์‚ฌํ•ญ์ด ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค.1.์ˆ˜์ˆ ์†Œ๊ฒฌ์€ ๋ฐฉ์‚ฌ์„ ์†Œ๊ฒฌ๋ณด๋‹ค ๋” ์ •ํ™•ํ•˜๋‹ค.2.์ˆ˜์ˆ ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ๋Š” ๋‚ด์‹œ๊ฒฝ์กฐ์ง๊ฒฐ๊ณผ๋ณด๋‹ค ์ •ํ™•ํ•˜๋‹ค.3.์ ˆ์ œํ•œ ํ‘œ๋ณธ์˜ ๋ณ‘๋ฆฌํ•™์  ์œ„์น˜๋Š” ์‹œ๊ฐ์  ๊ฒ€์‚ฌ๋ณด๋‹ค ๋” ์ •ํ™•ํ•˜๋‹ค.๊ทธ๋ ‡๋‹ค๋ฉด ์กฐ์งํ•™์ ์ง„๋‹จ๋ช…๋„ ์˜๋ฌด๊ธฐ๋ก ๊ฒฐ๊ณผ๋ณด๊ณ ์„œ ๋‚ด์šฉ ์ƒ์ถฉ์‹œ ๋™์ผํ•˜๊ฒŒ ์ ์šฉ๋˜๋‚˜์š”? ์กฐ์งํ•™์ ์ง„๋‹จ๋ช…์€ ์˜๋ฌด๊ธฐ๋ก ๊ฒฐ๊ณผ๋ณด๊ณ ์„œ ๋‚ด์šฉ ์ƒ์ถฉ์‹œ ์–ด๋–ป๊ฒŒ ํ•˜๋Š”์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค. ๋‹ต๋ณ€๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
ํ•ด๋‹น ์ง€์นจ์€ ์›๋ฐœ๋ถ€์œ„์— ๊ตญํ•œ๋˜๋Š” ๋‚ด์šฉ์œผ๋กœ ์กฐ์งํ•™์  ์ง„๋‹จ๋ช…์€ ์‹ค์ œ case๋กœ ์งˆ๋ฌธ๋ฐ”๋ž๋‹ˆ๋‹ค.
2023/1/6 dyspnea ์ฃผํ˜ธ์†Œ๋กœ ์ž…์›ํ•˜์—ฌ COPD ํ™•์ง„๋ฐ›์•„ ์ž…์› ์ค‘์ด๋˜ ํ™˜์ž.2023/1/16 ํ”ผ๋ถ€๊ณผ ํ˜‘์ง„ ์‹œํ–‰. ํ˜‘์ง„๊ธฐ๋ก์ง€[์–‘์ชฝ ๊ท€ Abrasion (์ง‘์—์„œ๋ถ€ํ„ฐ ์žˆ์—ˆ๋˜ ์˜ค๋ž˜๋œ ์ƒ์ฒ˜)์™ผ์ชฝ ์†๋“ฑ (์ด์ „ IV SITE๋กœ ์ถ”์ •๋ฉ๋‹ˆ๋‹ค.) abrasion]๋กœ r/o SCC ๋กœ skin bxํ•˜์˜€๊ณ  SqCC , MD ์ง„๋‹จ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.์ดˆ์ง„์ผ 2023/1/16 ์ง„๋‹จ๊ฒฝ๋กœ : ์ฆ์ƒ๋ฐœํ˜„์œผ๋กœ ๋ณด์—ฌ์ง€๋Š”๋ฐ ๋งž๋‚˜์š”?์•”๋“ฑ๋ก์ž๋ฃŒ ์„ค๋ช…์„œ์—๋Š”์ดˆ์ง„์ผ์ด ์ž…์›์ผ๋ณด๋‹ค ๋Šฆ์€ ๊ฒฝ์šฐ ์ง„๋‹จ๊ฒฝ๋กœ๊ฐ€ 2(์šฐ์—ฐํ•œ ๋ฐœ๊ฒฌ)์ธ ๊ฒฝ์šฐ๋งŒ ๊ฐ€๋Šฅํ•œ ๊ฒƒ์œผ๋กœ ์•Œ๊ณ  ์žˆ์–ด์„œ ์œ„์˜ ์ผ€์ด์Šค์—๋Š” ์ดˆ์ง„์ผ ๋ฐ ์ง„๋‹จ๊ฒฝ๋กœ ์–ด๋–ป๊ฒŒ ์ค˜์•ผ ๋ ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค-----------------------------------------------------------------------------๋‹ต๋ณ€ : ์ดˆ์ง„์ผ- 2023/01/16, ์ง„๋‹จ๊ฒฝ๋กœ- 3(์ฆ์ƒ๋ฐœํ˜„)์œผ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.------------------------------------------------------------------------------์œ„์— ๋‹ต๋ณ€ ์ฃผ์‹ ๋Œ€๋กœ ์•”๋“ฑ๋ก ํ•˜์˜€๋Š”๋ฐ, ์ด๋ฒˆ์— F2 ์˜ค๋ฅ˜๊ฐ€ ๋‚˜์™”์Šต๋‹ˆ๋‹ค. KF2๋กœ ์ž…๋ ฅํ•  ์ˆ˜ ์žˆ๋Š” ๊ฒฝ์šฐ๋Š” ์ดˆ์ง„์ผ์ด ์ž…์›์ผ๋ณด๋‹ค ๋Šฆ์€ ๊ฒฝ์šฐ๋ฉด์„œ ์ง„๋‹จ๊ฒฝ๋กœ๊ฐ€ 2(์šฐ์—ฐํ•œ ๋ฐœ๊ฒฌ)์ธ ๊ฒฝ์šฐ๋งŒ ์ž…๋ ฅํ•˜๋ผ๊ณ  ๋˜์–ด์žˆ๋Š”๋ฐ, ๋น„๊ณ ์— ์จ๋‘๋ฉด ๋ ๊นŒ์š”?
์œ ์„ ํ†ตํ™”
,์„ ์ƒ๋‹˜๋ถ•์†Œ์ค‘์„ฑ์žํฌํš์น˜๋ฃŒ(BNCT, Boron Neutron Capture Therapy)๋ฅผ ์‹œํ–‰ํ•œ ํ™˜์ž ์•”๋“ฑ๋ก์‹œ ์น˜๋ฃŒ ์—…๋ฐ์ดํŠธ ๋ฐฉ๋ฒ•์— ๋Œ€ํ•ด ์—ฌ์ญ™๊ณ  ์‹ถ์Šต๋‹ˆ๋‹ค.RT ์น˜๋ฃŒ์˜ ์ผ์ข…์ด๋ฏ€๋กœ ๋ฐฉ์‚ฌ์„ ๋งŒ ์—…๋ฐ์ดํŠธ๋ฅผ ํ•˜๋Š”์ง€, ์•„๋‹ˆ๋ฉด ๊ธฐํƒ€์—๋„ ์—…๋ฐ์ดํŠธ๋ฅผ ํ•˜๋Š”์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค. ํ™•์ธํ•˜์‹œ์–ด ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
๋ฐฉ์‚ฌ์„ ์น˜๋ฃŒ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
, ๊ฐ„์•” ์กฐ์งํ•™์  ์ง„๋‹จ๋ช…์— ๋Œ€ํ•ด ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ------------------------------------------------------------------2023/11/20 Liver bx: poorly differentiated carcinoma, favor hepatocellular carcinoma 2023/12/26 Liver (Ectomy)(Des)[Histochemistry],Tissue ]DIAGNOSIS : B) Liver, ( segment 5 and 8 ), right anterior sectionectomy: - INTERMEDIATE CELL CARCINOMA, 4.6 x 3.5 x 2.8 cm, SEGMENT 8, with 1) confinement to hepatic parenchyma 2) lymphovascular invasion: not identified 3) perineural invasion: not identified 4) resection margin: clear ( 1.7 cm ). - Chronic liver disease, hepatitis B virus-associated, with septal fibrosis.A) Gallbladder, cholecystectomy: - Cholesterol polyps, multiple, up to 0.5 cm in greatest dimension.์˜์‚ฌ ์ง„๋‹จ: HBV HCC 4.6 cm LVi(-) s/p RAS 2023. 12. 26 ------------------------------------------------------------------ INTERMEDIATE CELL CARCINOMA์— ํ•ด๋‹นํ•˜๋Š” ์ฝ”๋“œ๊ฐ€ ์—†์–ด์„œ ์–ด๋–ค ์กฐ์งํ•™์ ์ง„๋‹จ๋ช…์œผ๋กœ ๋“ฑ๋กํ•ด์•ผํ•˜๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ํ™•์ธ ํ›„ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
M8170/3(Hepatocellular carcinoma, NOS(C22.0))๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
์„ ์ƒ๋‹˜ ์ˆ˜๊ณ ๋งŽ์œผ์‹ญ๋‹ˆ๋‹ค. KCD-8 ์ฐจ ์ƒ‰์ธ์—์„œ Essential thrombocythemia์™€ Essential thrombocytosis๋Š” ๋™์ผํ•˜๊ฒŒ D47.3 ์œผ๋กœ ๋ถ„๋ฅ˜ํ•˜๋ฉฐ, Essential thrombocythemia๋Š” ICD-O-3์— ๋”ฐ๋ผ ์•”๋“ฑ๋ก ๋Œ€์ƒ์ด๋ฉ๋‹ˆ๋‹ค. ๋ฌธํ—Œ์„ ์ฐพ์•„๋ณด๋‹ˆ Essential thrombocythemia = Essential thrombocytosis '๋ณธํƒœ์„ฑํ˜ˆ์†ŒํŒ์ฆ๊ฐ€์ฆ'์œผ๋กœ ํ•ด์„ํ•˜๋Š” ๊ฒฝ์šฐ๊ฐ€ ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ๋ณด์•„ Essential thrombocytosis๋„ ์•”๋“ฑ๋ก ๋Œ€์ƒ์œผ๋กœ ๋ณผ์ˆ˜์žˆ๋Š”์ง€ ํ™•์ธ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.์ด์ „ ์งˆ์˜์—์„œ thrombocytosis๋Š” ๋Œ€์ƒ์ด ์•„๋‹ˆ๋ผ๊ณ  ํ™•์ธํ•˜์˜€๋Š”๋ฐ, Essential์ธ ๊ฒฝ์šฐ๋„ ํ•จ๊ป˜ ๋ง์”€ํ•˜์‹œ๋Š”์ง€ ํ˜ผ๋™์ด ๋˜์–ด ์งˆ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
Thrombocytosis๋Š” ๋“ฑ๋ก๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค. ICD-O-3์ƒ์œผ๋กœ Essential thrombocythemia(M9962/3)๋งŒ ๋“ฑ๋ก๋Œ€์ƒ์ด์ง€๋งŒ, ์˜์‚ฌ์„ ์ƒ๋‹˜๋“ค๋งˆ๋‹ค ๋‘ ์šฉ์–ด๋ฅผ ํ˜ผ์šฉํ•˜์‹œ๋Š” ๊ฒฝ์šฐ๊ฐ€ ๋งŽ์ด ์žˆ์Šต๋‹ˆ๋‹ค. ๋”ฐ๋ผ์„œ ํ•ด๋‹น ๋ณ‘์›์˜ ์˜์‚ฌ์„ ์ƒ๋‹˜๊ป˜ ์ •ํ™•ํ•œ ์ง„๋‹จ๋ช…์„ ํ™•์ธํ•˜์‹  ํ›„ ๋“ฑ๋ก์—ฌ๋ถ€๋ฅผ ๊ฒฐ์ •ํ•˜์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.
TUR-BT ์‹œํ–‰ํ•˜์‹  ํ™˜์ž๋ถ„ ์กฐ์ง๊ฒ€์‚ฌ์ƒ, Urinary bladder, TUR-BT: Urothelial carcinoma with 1) no invasion of lamina propria 2) no lymphovascular emboli 3) no muscle component ์œผ๋กœ ํŒ๋…๋˜์—ˆ์Šต๋‹ˆ๋‹ค. urothelial carcinoma ์ธ๋ฐ no invasion of lamina propria ์ธ ๊ฒฝ์šฐ์–ด๋–ป๊ฒŒ ์•”๋“ฑ๋กํ•˜๋ฉด ๋˜๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
M8120/2(Urothelial carcinoma in situ)๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
Stomach, total gastrectomy :Advanced gastric carcinoma(pT4aN0)1. tumor focality : single2. Location : meddle third, center at body, greater curvature3. Gross type : Borrmann type 34. histologic type : poorly differentiated carcinoma with amphophilic cytoplasm and solic and sheet pattern, consistent with hepatiod adenocarcinoma์ผ ๊ฒฝ์šฐ M ์ฝ”๋“œ๋ฅผ ๋ฌธ์˜ํ•ฉ๋‹ˆ๋‹ค.
M8576/3(Hepatoid adenocarcinoma)๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค. *[bigo]์— ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋ฅผ ๊ธฐ์žฌ๋ฐ”๋ž๋‹ˆ๋‹ค.*
[DIAGNOSIS] Pancreas, common bile duct and duodenum, laparoscopic total pancreatectomy (#1); Intraductal papillary neoplasm with associated invasive carcinoma with 1) gross type: infiltrative 2) tumor size: 3.0x1.8x5.0cm 3) depth of invasion: tumor >4cm in greatest dimension (pT3) 4) bile duct invasion: no invasion 5) duodenal invasion: no invasion 6) surgical margin: free from tumor (safety margin: pancreastic duct- 0.5cm, common bile duct- 1.0cm, radial- 0.2cm) 7) lymph node: no metastasis in out of 7 lymph nodes (pN0) 8) angiolymphatic invasion: not identified 9) venous invasion: not identified 10) perineural invasion: not identified 11) tumor border: infiltrative 12) Pancreatic intraepithelial mucinous neoplasm: present (high grade) ์ง„๋ฃŒ๊ธฐ๋ก์ง€์— IPMN, invasive carcinoma T3NO ์ž‘์„ฑ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.---------------------------------------------------------------------------C259(Pancreas, unspecified)+๋ชฐํฌ๋กœ์ง€๋ฅผ M8453/3(C25._) M8503/3(C50._) ์ค˜์•ผํ• ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
IPMN์œผ๋กœ ์ง„๋‹จ๋œ ๊ทผ๊ฑฐ๊ฐ€ ํ™•์ธ๋˜์ง€ ์•Š์œผ๋ฉด ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ์— ๋”ฐ๋ผ M8503/3(Intraductal papillary neoplasm with associated invasive carcinoma)๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
Rib, sono-guided biopsy; Monoclonal plasma cell infiltration with fat necrosis and hyalinization, rule out 1) monoclonal gammopathy of undetermined significance (MGUS) 2) smoldering multiple myeloma 3) multiple myeloma์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ๊ฐ€ ์œ„์™€ ๊ฐ™์ด ๋ณด๊ณ ๋˜์—ˆ๊ณ ์ง„๋‹จ์€ Solitary plasmacytoma of bone ๋กœ ๋‚ด๋ ค์กŒ์Šต๋‹ˆ๋‹ค.์•”๋“ฑ๋ก์‹œ M์ฝ”๋“œ๋Š” ๋ฌด์—‡์œผ๋กœ ์ฃผ๋ฉด๋˜๋Š”์ง€ ..ํ™•์ธ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
M9731/3(Solitary plasmacytoma)๋Š” ๋น„ํ˜„๋ฏธ๊ฒฝ์  ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ๋กœ๋Š” ์ฝ”๋”ฉํ•  ์ˆ˜ ์—†์–ด ์กฐ์งํ•™์  ๊ฒ€์‚ฌ ๊ทผ๊ฑฐ๊ฐ€ ์—†๋‹ค๋ฉด ์ง„๋‹จ๋ฐฉ๋ฒ• 1, M8000/3์œผ๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.
2023/1/6 dyspnea ์ฃผํ˜ธ์†Œ๋กœ ์ž…์›ํ•˜์—ฌ COPD ํ™•์ง„๋ฐ›์•„ ์ž…์› ์ค‘์ด๋˜ ํ™˜์ž.2023/1/16 ํ”ผ๋ถ€๊ณผ ํ˜‘์ง„ ์‹œํ–‰. ํ˜‘์ง„๊ธฐ๋ก์ง€ [์–‘์ชฝ ๊ท€ Abrasion (์ง‘์—์„œ๋ถ€ํ„ฐ ์žˆ์—ˆ๋˜ ์˜ค๋ž˜๋œ ์ƒ์ฒ˜) ์™ผ์ชฝ ์†๋“ฑ (์ด์ „ IV SITE๋กœ ์ถ”์ •๋ฉ๋‹ˆ๋‹ค.) abrasion]๋กœ r/o SCC ๋กœ skin bxํ•˜์˜€๊ณ  SqCC , MD ์ง„๋‹จ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.์ดˆ์ง„์ผ 2023/1/16 ์ง„๋‹จ๊ฒฝ๋กœ : ์ฆ์ƒ๋ฐœํ˜„์œผ๋กœ ๋ณด์—ฌ์ง€๋Š”๋ฐ ๋งž๋‚˜์š”?์•”๋“ฑ๋ก์ž๋ฃŒ ์„ค๋ช…์„œ์—๋Š”์ดˆ์ง„์ผ์ด ์ž…์›์ผ๋ณด๋‹ค ๋Šฆ์€ ๊ฒฝ์šฐ ์ง„๋‹จ๊ฒฝ๋กœ๊ฐ€ 2(์šฐ์—ฐํ•œ ๋ฐœ๊ฒฌ)์ธ ๊ฒฝ์šฐ๋งŒ ๊ฐ€๋Šฅํ•œ ๊ฒƒ์œผ๋กœ ์•Œ๊ณ  ์žˆ์–ด์„œ ์œ„์˜ ์ผ€์ด์Šค์—๋Š” ์ดˆ์ง„์ผ ๋ฐ ์ง„๋‹จ๊ฒฝ๋กœ ์–ด๋–ป๊ฒŒ ์ค˜์•ผ ๋ ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค
์ดˆ์ง„์ผ- 2023/01/16, ์ง„๋‹จ๊ฒฝ๋กœ- 3(์ฆ์ƒ๋ฐœํ˜„)์œผ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
๊ฐ‘์ƒ์„ ์•” ์ˆ˜์ˆ ์‹œ ์กฐ์ง๊ฒ€์‚ฌ๋กœ ์•„๋ž˜์™€ ๊ฐ™์ด ๋ณด๊ณ ๋˜์—ˆ๋Š”๋ฐ ๋‘๊ฐ€์ง€ ์งˆ๋ฌธ์ด ์žˆ์Šต๋‹ˆ๋‹ค.1. M์ฝ”๋“œ ๋ฌธ์˜: right thyroid mass์—์„œ๋Š” PAPILLARY CARCINOMA M8260/3๋ฅผ ์ฃผ๊ณ  left thyroid middle mass์—์„œ๋Š” Encapsulated follicular variant of papillary thyroid carcinoma M8349/1๋กœ ์ฃผ๋ฉด ๋˜๋Š”๊ฑธ๊นŒ์š”? 2. ์•”๋“ฑ๋ก๋Œ€์ƒ: PAPILLARY CARCINOMA M8260/3์— ๋Œ€ํ•ด์„œ๋งŒ ํ•ด์ฃผ๋ฉด ๋˜๋Š”๊ฑธ๊นŒ์š”?Thyroid gland, partial thyroidectomy:1. Multiple PAPILLARY CARCINOMAS (x2)1-1. PAPILLARY CARCINOMA, Classical(usual) (2022 WHO classification)(A, "right thyroid mass")1) Tumor Site: Right lobe2) Tumor Focality: Unifocal3) Tumor Size (greatest dimension): 0.8 cm (right lobe, upper pole)1-2. Encapsulated follicular variant of papillary thyroid carcinoma (2022 WHO classification) (see comments)(C, "left thyroid middle mass")1) Tumor Site: Left lobe2) Tumor Focality: Unifocal3) Tumor Size (greatest dimension): 1.7 cm (left lobe)2. Pathologic Staging of Primary Tumor (pT) (according to AJCC 8th):Tumor more than 1 cm but not more than 2 cm in greatest dimension, limited to the thyroid (pT1b)3. Resection Margins: Uninvolved by carcinoma4. Tumor Capsule: PRESENT (Totally)5. Tumor Capsular Invasion: Not identified6. Lymph-Vascular Invasion: Indeterminate7. Lymph nodes: Not submitted8. Additional Pathologic Findings: (1) Nodular goiter (B, "right lower thyroid mass") (2) Follicular adenoma, 0.6 cm (D, "left thyroid lower mass")9. Parathyroid gland: Not identified
์ขŒ์ธก์€ M8349/1 Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)(C73.9), ์šฐ์ธก์€ M8260/3 Papillary adenocarcinoma, NOS๋กœ ์ž๋ฌธ๋‹ต๋ณ€ ๋ฐ›์•˜์Šต๋‹ˆ๋‹ค. M8349/1์€ ์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ์•„๋‹ˆ๋ฏ€๋กœ M8260/3๋งŒ ์•”๋“ฑ๋ก๋ฐ”๋ž๋‹ˆ๋‹ค.
.์•”๋“ฑ๋ก์‹œ ์ˆ˜์ˆ ์น˜๋ฃŒ๊ด€๋ จํ•˜์—ฌ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.ํƒ€๋ณ‘์›์—์„œ ํ”ผ๋ถ€๋ณ‘๋ณ€์— ๋Œ€ํ•ด excision ํ›„ BASAL CELL CARCINOMA ์ง„๋‹จ๋˜์–ด ๋‚ด์›ํ•œ ๋ถ„์ž…๋‹ˆ๋‹ค. ํƒ€๋ณ‘์› ๋ณ‘๋ฆฌ๊ฒ€์‚ฌ๊ฒฐ๊ณผ:Skin, cheek, excision (2023.12.08);BASAL CELL CARCINOMA์ˆ˜์ˆ ํ•ญ๋ชฉ์€ '์ง„๋‹จ ๋ชฉ์ ์˜ ์กฐ์ง๊ฒ€์‚ฌ๋Š” ํฌํ•จ๋˜์ง€ ์•Š์œผ๋ฉฐ ์•”๊ณผ ์—ฐ๊ด€๋œ ์ง์ ‘์ ์ธ ์น˜๋ฃŒ'๋งŒ์„ ์ž…๋ ฅํ•œ๋‹ค๊ณ  ์•Œ๊ณ ์žˆ๋Š”๋ฐ, ์œ„ ๊ฒฝ์šฐ์ฒ˜๋Ÿผ excisional biopsy๋ฅผ ์‹œํ–‰ํ•œ ๊ฒฝ์šฐ ์ˆ˜์ˆ ์— ํฌํ•จ๋  ์ˆ˜ ์žˆ๋‚˜์š”?๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค!
๋ชจ๋“  excision์€ ์ง„๋‹จ ๋ชฉ์ ์˜ ์กฐ์ง๊ฒ€์‚ฌ์— ํฌํ•จ๋˜์ง€ ์•Š์œผ๋ฉฐ, ์œ„์™€ ๊ฐ™์€ ๊ฒฝ์šฐ excision ํ›„ ์ž”์—ฌ๋ณ‘๋ณ€์— ๋Œ€ํ•œ ์–ธ๊ธ‰์ด ์—†๋‹ค๋ฉด ์ˆ˜์ˆ ์น˜๋ฃŒ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
.Breast cancer์˜ Morphology ์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.=======================================1. Invasive ductal carcinoma with neuroendocrine differentiation=======================================์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ๊ฐ€ ์œ„์™€ ๊ฐ™์ด ๋ณด๊ณ ๋œ ์ผ€์ด์Šค๋กœ Morphology ์ฝ”๋“œ๋ฅผM8500/3 or M8574/3 ์ค‘ ์–ด๋–ค ๊ฒƒ์œผ๋กœ ์ฃผ์–ด์•ผ ํ•˜๋Š”์ง€ ์žฌ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.( โ€ป ์ด์ „ ๋™์ผํ•œ ์งˆ๋ฌธ์— ๋Œ€ํ•œ ๋‹ต๋ณ€์€ M8574/3 (Adenocarcinoma with neuroendocrine differentiation)์œผ๋กœ ๋ถ€์—ฌํ•˜๋ฉด ๋œ๋‹ค๋Š” ๊ฒƒ์€ ํ™•์ธํ•˜์˜€์Šต๋‹ˆ๋‹ค. )๊ถ๊ธˆํ•œ ์ ์€ Breast cancer๊ฐ€ ์•„๋‹Œ endometrium์˜ 'Endometrioid carcinoma, low grade with neuroendocrine differentiation'์— ๋Œ€ํ•ด์„œ๋Š” M8574/3์ด ์•„๋‹Œ,M8380/3์œผ๋กœ ๋ถ€์—ฌํ•˜๋ผ๊ณ  ์•ˆ๋‚ดํ•ด์ฃผ์…จ์—ˆ๋Š”๋ฐ,๋‘ ์ผ€์ด์Šค์— Morphology๊ฐ€ ๋‹ค๋ฅด๊ฒŒ ๋ถ€์—ฌ๋˜๋Š” ์ด์œ ๊ฐ€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค.Invasive ductal carcinoma with neuroendocrine differentiation ๋กœ ๋ณด๊ณ ๋œ๊ฒฝ์šฐ์—๋งŒ 'with neuroendocrine differentiation'๋ฅผ ๋ฐ˜์˜ํ•˜์—ฌM8574/3์œผ๋กœ ์ฃผ๋ฉด ๋˜๋Š”์ง€ ์žฌํ™•์ธ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค~!
carcinoma, adenocarcinoma NOS์˜ ๊ฒฝ์šฐ with differentiation์„ ๋ฐ˜์˜ํ•˜์ง€๋งŒ, ์œ„ ์ผ€์ด์Šค๋Š” ductal carcinoma์ด๋ฏ€๋กœ M8500/3(Ductal carcinoma, NOS)๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
Liver, biopsy; EBV-positive T cell lymphoproliferative lesion (see note)์ž„์ƒ ์ง„๋‹จ : Chronic active EBV infection of T cell typechronic active EBV infection, cellulitis๋กœ Admlymphoproliferated disorder ์˜ liver involvment๋กœ ๊ฐ„์ˆ˜์น˜ ์ƒ์Šน์•”๋“ฑ๋ก ๋Œ€์ƒ ์—ฌ๋ถ€ ๋ฐ M code ํ™•์ธ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค.
์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ duodenum dysplasia, high grade์œผ๋กœ ๋‚˜์™”์Šต๋‹ˆ๋‹ค. ์ €ํฌ ๋ณ‘์› ์กฐ์ง๊ฒ€์‚ฌ์‹ค์€ ์ œ์ž๋ฆฌ์•”์œผ๋กœ ๋ณด์‹ ๋‹ค๊ณ  ํ•˜์…จ๋Š”๋ฐ, KCD 8์ฐจ ์ƒ‰์ธ์—๋Š” dysplasia-high grade-duodenum์œผ๋กœ๋Š” ์ „ํ˜€ ๋‚˜์˜ค์ง€ ์•Š์œผ๋ฉฐ ์•”๋“ฑ๋ก ์ง€์นจ์„œ๋Š” high grade๋ฅผ /2๋กœ ๋ณด๋Š” ์›๋ฐœ๋ถ€์œ„์— ํฌํ•จ๋˜์–ด ์žˆ์ง€ ์•Š๊ณ  ์ž„์ƒ์˜์™€ ํ˜‘์˜ํ›„ ๊ฒฐ์ •์ด๋ผ๊ณ  ๊ธฐ์žฌ๋˜์–ด ์žˆ์Šต๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ๊ฒฝ์šฐ ์ œ์ž๋ฆฌ์•”์œผ๋กœ ๋ณด๊ณ  ์•”๋“ฑ๋ก์„ ํ•˜๋Š”๊ฒŒ ๋งž๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
์ฃผ์น˜์˜๊ฐ€ /2๋กœ ์ธ์ •ํ•œ ๊ฒฝ์šฐ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.*[bigo]์— ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋ฅผ ๊ธฐ์žฌ๋ฐ”๋ž๋‹ˆ๋‹ค.*
~์ด๋ฒˆ ์ž…์›์‹œ bx์ƒureter ์—์„œ 8130/3 Infiltrating urothelial carcinoma ๋‚˜์™”๊ณ bladder์—์„œ 8120/2 Non-invasive papillary urothelial carcinoma ๋‚˜์™”์Šต๋‹ˆ๋‹ค.C66 ureter์™€ C67 bladder๋Š” ๋™์ผ์žฅ๊ธฐ๊ตฐ์œผ๋กœ ๊ฐ„์ฃผ๋˜๊ณ , 8120-8131๋„ ๋™์ผ ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์œผ๋กœ ๊ฐ„์ฃผ๋˜๋Š”๋ฐ C66์€ localized์ด๊ณ  C37์€ in-situ ์ž…๋‹ˆ๋‹ค.์ด๋Ÿฐ ๊ฒฝ์šฐ์— ์•”๋“ฑ๋ก์€ C68.9 M8130/3์œผ๋กœ ์ฃผ๋ฉด ๋ ๋Ÿฐ์ง€,์•„๋‹ˆ๋ฉด ๊ฐ๊ฐ ํ•ด์ค˜์•ผ๋˜๋Š”๊ฑด์ง€ ํ•ด์„œ์š”~
์•…์„ฑ์„ ์šฐ์„ ์œผ๋กœ ํ•˜์—ฌ C66.9, M8120/3(Urothelial carcinoma, NOS)๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
postmolar GTN ์— ๋Œ€ํ•ด ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.ํ™˜์ž ์กฐ์ง๊ฒ€์‚ฌ๋กœ๋Š” H-mole ๋‚˜์™€ D&E ์‹œํ–‰ํ•˜์˜€์œผ๋‚˜ B-HCG ์ˆ˜์น˜๊ฐ€ ๊ฐ์†Œํ•˜์ง€ ์•Š์•„ ์ฃผ์น˜์˜ ์ž„์ƒ์†Œ๊ฒฌ ์ƒ Postmolar GTN (H-mole, partial), more than stage 3 ์œผ๋กœ ์ตœ์ข… ์ง„๋‹จ๋ฐ›์œผ์‹  ๋ถ„์ž…๋‹ˆ๋‹ค.๊ฒ€์‚ฌ ์†Œ๊ฒฌ์€ ํ•˜๊ธฐ์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค.TV-USG: partial mole preg.(7.6*5.2cm)Lab.: WNL (including TFT) / APCT: Suspicious residual endometrial thickening, C-CT: Multiple variable sized nodules in the both lungs.- suggested metastatic nodulesC58 ์ง„๋‹จ ํ•˜ EMACO ํ•ญ์•”์น˜๋ฃŒ ํ•˜๊ณ  ๊ณ„์‹œ๋Š”๋ฐ ์ด๋Ÿฌํ•œ ๊ฒฝ์šฐ M9100/1 ๋กœ ์•”๋“ฑ๋ก์„ ํ•˜์ง€ ์•Š์•„๋„ ๋˜๋Š”๊ฑด์ง€, ์•„๋‹ˆ๋ฉด M9100/3 ๋กœ ์•”๋“ฑ๋ก์„ ํ•ด์•ผ ํ•˜๋Š”๊ฑด์ง€ ๋ฌธ์˜๋“œ๋ฆฌ๊ณ  ์‹ถ์Šต๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
Choriocarcinoma(9100/3)๋กœ ์ง„ํ–‰๋˜์ง€ ์•Š๊ณ  Malignant hydatidiform mole(9100/1)์ƒํƒœ๋ผ๋ฉด ์•”๋“ฑ๋ก ๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค.
Pancreas, common bile duct, and duodenum, pylorus preserving pancreatico-duodenectomy; Adenocarcinoma, moderately differentiated with focal squamous differentiation, consistent with adenosquamous carcinoma, common bile duct, with~์›๋ฐœ์ฝ”๋“œ C24.0 ์ž…๋‹ˆ๋‹คM์ฝ”๋“œ ๋ฌธ์˜ํ•ฉ๋‹ˆ๋‹ค.
M8560/3(Adenosquamous carcinoma)๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
, ์•”๋“ฑ๋ก ์—ฌ๋ถ€ ๋ฐ M์ฝ”๋“œ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ธฐ์ €์งˆํ™˜ ์—†๋Š” ๋ถ„์œผ๋กœ 2๋‹ฌ ์ „ ์˜ค๋ฅธ์ชฝ ์•„๋ž˜ ์ž‡๋ชธ์— ํ˜น ๋ฐœ๊ฒฌ๋˜์–ด local ๊ฐ”๋Š”๋ฐ ์กฐ์ง ๊ฒ€์‚ฌ ํ•„์š”ํ•˜๋‹ค๊ณ  ํ•˜์—ฌ ํƒ€์›์—์„œ ์‹œํ–‰ํ•œ Bx ์ƒ SCC ๋ฐ ameloblastoma ๋“ฑ ๋‹ค์ˆ˜์˜ ์†Œ๊ฒฌ์ด ๋ช…ํ™•ํžˆ ํ™•์ •๋˜์ง€ ๋ชปํ•˜์—ฌ ๋ณธ์› ๋‚ด์› ํ›„ 11/9 L/A๋กœ biopsy ์‹œํ–‰ํ•˜์…จ๋‹ค๊ฐ€ ์ˆ˜์ˆ  ์œ„ํ•ด ์ž…์›ํ•˜์‹  ๋ถ„์ž…๋‹ˆ๋‹ค. 1) bx ๋ณ‘๋ฆฌ ๊ฒฐ๊ณผ **** ใ€์ตœ์ข…๋ณด๊ณ ใ€‘ ****Oral cavity, #47 gingiva, right, incisional biopsy; R/O 1. Ameloblastic carcinoma 2. Ameloblastoma, peripheral type 3. Basaloid squamous cell carcinomaNote) Pathologic-radiologic correlation and complete excision are necessary for the diagnosis.๋ณธ์›์—์„œ ์‹œํ–‰ํ•œ ์ƒ๊ฒ€์†Œ๊ฒฌ๊ณผ ์ข…ํ•ฉํ•˜์—ฌ ์ง„๋‹จํ•˜์˜€์Šต๋‹ˆ๋‹ค.------------------------------------------------------ 2) ์ˆ˜์ˆ  ํ›„ ๋ณ‘๋ฆฌ ๊ฒฐ๊ณผ**** ใ€์ตœ์ข…๋ณด๊ณ ใ€‘ ****Oral cavity, right, retromolar pad area(No.1), excision; Ameloblastoma, peripheral / extraosseous type, with free resection margin Oral cavity, right, #47 lingual alveolar bone(No.2), excision; No tumor Lymph node, labeled as "Rt.perivascular lymph node"(No.3), biopsy; No metastasis in 1 lymph node (0/1) Note) Previous biopsy ์—์„œ BRAF V600E ์–‘์„ฑ์ด๋ฏ€๋กœ ์žฌ๋ฐœ ๊ฐ€๋Šฅ์„ฑ์ด ์žˆ์Šต๋‹ˆ๋‹ค. ์ถ”์ ๊ด€์ฐฐ ๋ฐ”๋ž๋‹ˆ๋‹ค. ------------------------------------------------------------------------- ์ตœ์ข… ๋ณ‘๋ฆฌ ๊ฒฐ๊ณผ Ameloblastoma, peripheral/ extraosseous type ํŒ๋…๋๋Š”๋ฐ, ์ˆ˜์ˆ  ํ›„ ์™ธ๋ž˜ ์ง„๋‹จ ์ฐธ๊ณ ํ•˜๋ฉด ์ž„์ƒ์—์„œ๋Š” ์•…์„ฑ์œผ๋กœ ๋ณด๊ณ  ์žˆ๋Š” ๊ฒƒ ๊ฐ™์Šต๋‹ˆ๋‹ค. ์œ„ ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋ฅผ M์ฝ”๋“œ /3, ์•…์„ฑ์œผ๋กœ ๋ณด๊ณ  ์•”๋“ฑ๋ก ํ•ด์•ผ ํ•˜๋Š”์ง€ ์งˆ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ์•”๋“ฑ๋ก ํ•œ๋‹ค๋ฉด M์ฝ”๋“œ๋Š” ์–ด๋–ค ์ฝ”๋“œ๋กœ ์ฃผ์–ด์•ผ ํ• ์ง€๋„ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค. ํ™•์ธํ•˜์‹  ํ›„ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค !
์ˆ˜์ˆ ํ›„ ์กฐ์ง๊ฒ€์‚ฌ์ƒ M9310/0(Ameloblastoma, NOS) ์œผ๋กœ ์•”๋“ฑ๋ก๋Œ€์ƒ์ด ์•„๋‹™๋‹ˆ๋‹ค.
Morphology์— Squamous cell carcinoma์ด๋ฉด์„œ HPV virus ยฑ (+)๋ฅผ ๋ฐ˜์˜ํ•˜๋Š” ์›๋ฐœ๋ถ€์œ„์— ๋Œ€ํ•ด ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.์•”๋“ฑ๋ก๊ต์œก์„ผํ„ฐ์˜ [์งˆ๋ฌธ๊ณผ ๋‹ต๋ณ€] ๊ฒ€์ƒ‰ ๊ฒฐ๊ณผ, Uterine cervix์™€ ๊ตฌ๊ฐ•์•”๊ณ„ํ†ต์— ์ ์šฉํ•˜๋Š” ๊ฒƒ์œผ๋กœ ํ™•์ธ์„ ํ•˜์˜€๋Š”๋ฐ, ๊ตฌ๊ฐ•์•” ๊ณ„ํ†ต์— ํ•ด๋‹นํ•˜๋Š” ํ•ด๋ถ€ํ•™์  ๋ถ€์œ„(ex. oral cavity, tongue etc.,)๊ฐ€ ์–ด๋–ป๊ฒŒ ๋˜๋Š”์ง€, ๊ทธ๋ฆฌ๊ณ  ๊ทธ ์™ธ์— HPV virus ยฑ (+)๋ฅผ ๋ฐ˜์˜ํ•ด์•ผํ•˜๋Š” ๋‹ค๋ฅธ ์›๋ฐœ๋ถ€์œ„๋„ ์žˆ๋Š”์ง€ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
๊ตฌ๊ฐ•์•”์˜ HPV(+), (-) ๊ด€๋ จ ์ฝ”๋“œ๋Š” ์ฃผ๋Š” ์›๋ฐœ๋ถ€์œ„์˜ ๋ฒ”์œ„๋Š” 'C00-C14' ์ž…๋‹ˆ๋‹ค.
colon cancer ํ™˜์ž Right hemicolectomy ์‹œํ–‰ํ•˜์—ฌ ๋‹ค์Œ๊ณผ ๊ฐ™์€ ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๊ฐ€ ๋‚˜์™”์Šต๋‹ˆ๋‹ค.Colon, terminal ileum and appendix, right hemicolectomy :- Poorly differentiated carcinoma, consistent with adenocarcinoma, poorly differentiated with neuroendocrine components and signet ring cell component, 9.5x5.5x2.0cm, transverse colon (See comment) with 1) invasion depth: pericolic adipose tissue 2) lymphovascular invasion: present - small vessel lymphovascular invasion: present - Intramural venous invasion: not identified - extramural venous invasion: not identified 3) perineural invasion: not identified 4) tumor budding: low score (0-4) 5) clear proximal and distal resection margins safety margins: proximal 11.5cm, distal 16.5cm 6) no metastasis in 22 lymph nodes : pericolic ; 0/19, r/o metastatic LN ; 0/1, mesenteric LN ; 0/2 7) tumor deposit : not identified 8) pathologic stage: pT3N0 (AJCC, 8th)- Adenocarcinoma, moderately differentiated, ascending colon, 2.5x2.4x0.8cm with 1) invasion depth : muscularis propria 2) lymphovascular invasion : present - small vessel lymphovascular invasion: present 3) perineural invasion : not identified 4) tumor budding : intermediate score (5-9) 5) clear proximal and distal resection margins- Appendix, hyperplastic polyp [COMMENT]Tumor consists of neuroendocrine morphology with focal positive for synaptophysin and negative for CD56, and chromogranin immunohistochemistry. Mixed adenoneuroendocrine carcinoma can be considered, however immunohistochemical result is not definite. Clinicopathologic correlation is recommended. [MOLECULAR PATHOLOGY]M24-000217 EBV in situ hybridization [๊ฒ€์‚ฌ๊ฒฐ๊ณผ]EBV in situ hybridization : negative in slide 1-4=> ์งˆ๋ฌธ* ์งˆ๋ฌธ 1morphology ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. 8574/3 : Carcinoma with neuroendocrine differentiation 8244/3 : Mixed adenoneuroendocrine carcinoma 8140/3 : Adenocarcinoma์ œ๊ฐ€ ์ฐพ์•„๋ณด์•˜์„๋•Œ ์œ„์™€๊ฐ™์ด ๋‚˜์˜ค๋Š”๋ฐ์ด์ค‘์— T-colon์€ 8574/3 , A-colon์€ 8140/3 ์œผ๋กœ ๊ฐ๊ฐ ์•”๋“ฑ๋ก ํ•˜๋Š” ๊ฒƒ์ด ๋งž๋‚˜์š”?(๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์ด ์•„๋‹˜)*์งˆ๋ฌธ 2ํ˜น์‹œ T-colon ๋ถ€์œ„์— ๋” ์ ํ•ฉํ•œ mophology ๊ฐ€ 8244/3 ์ด๋ผ๋ฉด, A-colon๊ณผ ๋™์ผ ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์œผ๋กœ ๋ณด์ด๋Š”๋ฐ ์ด๊ฒฝ์šฐ ์›๋ฐœ๋ถ€์œ„๋Š” T-colon๊ณผ A-colon ์ค‘์— ์–ด๋Š๊ฒƒ์œผ๋กœ ํ•ด์•ผํ•˜๋Š”์ง€๋„ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๋‹ด๋‹น์˜์‚ฌ๊ฐ€ ๋‘˜์ค‘ ์›๋ฐœ๋ถ€์œ„๋ฅผ ๋”ฐ๋กœ ์ •ํ•˜์ง€ ์•Š๋Š”๋‹ค๋ฉด C189 ๋กœ ์›๋ฐœ์„ ์ฃผ๋ฉด ๋˜๋Š” ๊ฒƒ์ผ๊นŒ์š”?๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
ํ•ด๋‹น์ผ€์ด์Šค๋Š” ์•„๋ž˜์™€ ๊ฐ™์ด ๋™์ผ์žฅ๊ธฐ๊ตฐ, ๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์œผ๋กœ 'C18.9 M8140/3' ์œผ๋กœ ํ•œ๋ฒˆ๋งŒ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.- transverse colon: M8140/3(adenocarcinoma)- ascending colon: M8140/3(adenocarcinoma)
๊ฐ‘์ƒ์„ ์•” ์˜์ฆ์œผ๋กœ ์ง„๋ฃŒ๋ฅผ ๊ณ„์† ๋ณด์‹œ๋‹ค๊ฐ€ ํ™•์ง„๋ฐ›์€ ํ™˜์ž ์ž…๋‹ˆ๋‹ค.์ ˆ์ œ์ˆ  ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ์™€ ์ด์ „ ์กฐ์ง ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ ์ฒจ๋ถ€ํ•˜์˜ค๋‹ˆ M์ฝ”๋“œ ํ™•์ธ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.[์ ˆ์ œ์ˆ  ๊ฒ€์‚ฌ์†Œ๊ฒฌ]Thyroid, right, frozen total unilateral thyroidectomy: Encapsulated angioinvasive oncocytic (Hurthle-cell) carcinoma 1. Tumor Focality: Unifocal 2. Tumor Laterality: Right lobe 3. Tumor Size: Greatest dimension: 3.5cm 4. Pathologic Staging of Primary Tumor (pT): pT2: 2 cm, but โ‰ค4 cm in greatest dimension, limited to thyroid 5. Extrathyroidal Extension (with no clinical/macroscopic evidence of invasion) Not identified 6. Margins: Uninvolved by carcinoma 7. Angioinvasion: Present (focal (< 4 vessels)) 8. Lymphatic invasion: Not identified 9. Perineural Invasion: Not identified 10. Additional Pathologic Findings: Not identified[์ด์ „ ์กฐ์ง ๊ฒ€์‚ฌ์†Œ๊ฒฌ]Thyroid gland, right lower, core needle biopsy: III. Indeterminate - Indeterminate follicular lesion with oncocytic (Hurthle cell) change
M8290/3(Hurthle cell carcinoma(C73.9), Oncocytic carcinoma) ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
์™ผ์ชฝ์œ ๋ฐฉ ๋ฉ์šธ๊ณผ ํ†ต์ฆ ์ฆ์ƒ์œผ๋กœ ์ฐพ์€ ์™ธ๋ถ€๋ณ‘์›์—์„œ 23.12.26 s/p Ex. mass ์ˆ˜์ˆ  ํ›„ ์™ผ์ชฝ ์œ ๋ฐฉ์•”์œผ๋กœ ์ง„๋‹จ๋ฐ›๊ณ  ์˜๋ขฐ๋˜์–ด ๋ณธ์›์—์„œ ์ˆ˜์ˆ  ์œ„ํ•ด ์ž…์›ํ•œ ํ™˜์ž๋กœ,ํƒ€๋ณ‘์› ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋Š” ๋‹ค์Œ๊ณผ ๊ฐ™์œผ๋ฉฐ2023-12-26 Breast, female, left 9h, excisional biopsy:** MALIGNANT BASALOID TUMOR, favor adenoid cystic carcinoma.R/O) Mucinous carcinoma.- Resection margins: Positive for tumor component.์œ„ ์Šฌ๋ผ์ด๋“œ๋ฅผ ๋ณธ์›์—์„œ ์žฌํŒ๋…๊ฒฐ๊ณผ ์•„๋ž˜์™€ ๊ฐ™์ด ์ง„๋‹จ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.Breast, left, 9 o'clock, excisional biopsy: Skin appendageal tumor, suggeative of SYRINGOID ECCRINE CARCINOMA2024-02-08 ๋ณธ์›์—์„œ ์ˆ˜์ˆ ์‹œํ–‰ํ›„ ์•„๋ž˜์™€ ๊ฐ™์ด ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๊ฐ€ ๋‚˜์™”์œผ๋ฉฐI)-II) Breast, nipple, left, breast conserving surgery with sentinel and axillary lymph node biopsy:Skin appendageal tumor, suggestive of SYNRINGOID ECCRINE CARCINOMA,post-excision status with 1) Tumor size: 0.9 x 0.8 x 0.4cm 2) Tumor border: infiltrative 3) Lymphovascular invasion: absent 4) Nipple and areola: involvement of deep dermis 5) Resection margins: free of tumor 6) Lymph nodes status: free of tumor (0/7) (See S24-1870) sentinel 1, 0/1; axillary, 0/6 -> ์ˆ˜์ˆ ํ›„ ์˜์‚ฌ๋Š” ์œ ๋ฐฉ์•”์—์„œ ํ”ผ๋ถ€์•”์œผ๋กœ ์ง„๋‹จ๋ช…์„ ๋ณ€๊ฒฝํ•˜์˜€์Šต๋‹ˆ๋‹ค.C44.5 ์›๋ฐœ๋กœ ์•”๋“ฑ๋กํ•˜๊ณ ์ž ํ•˜๋‚˜,Skin appendageal tumor, suggestive of SYNRINGOID ECCRINE CARCINOMA์™€ ๊ด€๋ จ๋œ์กฐ์งํ•™์ ๋ช…์ด ๋”ฐ๋กœ ์—†๋Š”๊ฒƒ๊ฐ™์•„ ์–ด๋–ป๊ฒŒ M์ฝ”๋“œ๋ฅผ ์ค˜์•ผํ• ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
M8413/3 Eccrine adenocarcinoma(C44._) ์œผ๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.
1๋ฒˆ ์งˆ๋ฌธStomach, totally laparoscopic total gastrectomy; - EARLY GASTRIC CARCINOMA.1) Location: upper third, center at fundus and anterior wall 2) Gross type: EGC type IIc3) Histologic type: tubular adenocarcinoma, moderately differentiated4) Histologic type by Lauren: intestinal 5) Size: 2.2x1.7 cm 6) Depth of invasion: invades submucosa (sm3) (pT1b)7) Resection margins, proximal and distal: free from carcinoma (safety margin: proximal 2.0 cm, distal 21.5 cm)8) Lymph node metastasis: no metastasis in 37 regional lymph nodes (pN0){No.1(0/2), No.2(0/0), No.3(0/11), No.4sb(0/0), No.4d(0/9), No.4sa(0/0), No.5(0/1), No.6(0/0), No.7(0/4), No.8(0/2), No.9(0/2), No.11p(0/4), No.11d(0/0) and No.12(0/2)}9) Lymphatic invasion: not identified10) Venous invasion: not identified11) Perineural invasion: not identified12) Stage โ… A- Gastrointestinal stromal tumor (GIST). 1) location: fundus and posterior wall 2) size: 0.9x0.6x0.4 cmtubular adenocarcinoma ์™€ GIST๊ฐ€ ๋™์ผ ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์— ํ•ด๋‹นํ•˜์ง€ ์•Š์œผ๋ฏ€๋กœ ๊ฐ๊ฐ ์•”๋“ฑ๋ก ํ•˜๋Š”๊ฒƒ์œผ๋กœ ์•Œ๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค.์•”๋“ฑ๋ก์‹œ C162 M8211/3, C162 M8936/3 ์œผ๋กœ ์•”๋“ฑ๋ก ๊ฐ๊ฐ ์ˆ˜ํ–‰ํ•˜๋Š”๊ฒŒ ๋งž๋Š”์ง€์š”?2๋ฒˆ ์งˆ๋ฌธC220, C221 ์ง„๋‹จ์ฝ”๋“œ์—์„œ Peritoneum seer 2๋กœ ๋ถ„๋ฅ˜๋ฉ๋‹ˆ๋‹ค.๊ทธ๋Ÿฐ๋ฐ peritoneum seeding ์ผ ๊ฒฝ์šฐ๋Š” distant(seer 7)๋กœ ๋ณธ๋‹ค๋Š” ๊ณผ๊ฑฐ ๋‹ต๋ณ€ ๋ณด์•˜์Šต๋‹ˆ๋‹ค.peritoneum seeding์€ ๋ถ€์œ„ ์ƒ๊ด€์—†์ด seer 7๋กœ ๋ณด๋Š”๊ฒŒ ๋งž๋Š”์ง€ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๋ถ€์œ„์— ๋”ฐ๋ผ ๋‹ค๋ฅด๋‹ค๋ฉด ์–ด๋–ค๊ฒƒ์„ ๋ณด๊ณ  ํŒ๋‹จํ•˜๋ฉด ๋˜๋Š”์ง€ ์„ค๋ช… ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
๋‹ต1) ๋„ค~ ๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์— ํ•ด๋‹นํ•˜์ง€ ์•Š์œผ๋ฏ€๋กœ ๊ฐ๊ฐ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.๋‹ต2) ๋„ค~ ๋งž์Šต๋‹ˆ๋‹ค. C22 ์—์„œ peritoneum ์œผ๋กœ direct invasion ์ธ ๊ฒฝ์šฐ: SEER 2 ๋กœ ์ฝ”๋”ฉ peritoneum seeding ์€ distant metastasis ์ธ ๊ฒฝ์šฐ๋กœ ๋ถ€์œ„์— ์ƒ๊ด€์—†์ด SEER '7'๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.
. Morphology ๊ฒฐ๊ณผ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.- Bx.๊ฒฐ๊ณผ : Colon, SD junction, colonoscopic biopsy : ห™Adenocarcinoma with mucin๋กœ ๋ณด๊ณ ๋œ CASE ์ž…๋‹ˆ๋‹ค. ์ด ๊ฒฝ์šฐ Morphology ์ฝ”๋“œ M8140/3์ธ์ง€, M8480/3์ธ์ง€ ๊ถ๊ธˆํ•ฉ๋‹ˆ๋‹ค.๋ฐ”์˜์‹œ๊ฒ ์ง€๋งŒ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค.๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค~
M8140/3(adenocarcinoma)๋กœ ์ฝ”๋”ฉํ•˜๋Š” ๊ฒƒ์ด ๋งž์Šต๋‹ˆ๋‹ค.
๋ถ€์‚ฐ๋Œ€๋ณ‘์› ๋ณด๊ฑด์˜๋ฃŒ์ •๋ณดํŒ€ ์•”๋“ฑ๋ก ๋‹ด๋‹น ์ด์€์ˆ™์ž…๋‹ˆ๋‹ค. ์กฐ์ง๊ฒฐ๊ณผ : Pituitary gland, trans sphenoidal approach : Coagulation necrosis of pituitary neuroendocrine tumor ์œ„์™€ ๊ฐ™์ด ๊ฒฐ๊ณผ ๋‚˜์˜จ ์ผ€์ด์Šค์ž…๋‹ˆ๋‹ค. - ๊ต์ˆ˜๋‹˜๊ป˜ ๋ฌธ์˜ํ•œ ๊ฒฐ๊ณผ, pituitary neuroendocrine tumor๋Š” pituitary adenoma๋กœ ์ผ๋˜ ์šฉ์–ด๋ฅผ ๋ณ€๊ฒฝ(2023๋…„๋ถ€ํ„ฐ)ํ•ด์„œ ์“ฐ๋Š” ๊ฒฝ์šฐ๋ผ์„œ pituitary NET๋Š” 99.9% ์–‘์„ฑ์ข…์–‘์ด๋ผ๋Š” ๋‹ต๋ณ€์„ ๋ฐ›์•˜์Šต๋‹ˆ๋‹ค. - 2021๋…„ ๋ณ€๊ฒฝ๋œ ์•”๋“ฑ๋ก ์ง€์นจ์— ๋”ฐ๋ฅด๋ฉด NET(tubular carcinoid ์ œ์™ธ)๋Š” all sites์— ๋Œ€ํ•ด /3(์•…์„ฑ)์œผ๋กœ ๋“ฑ๋กํ•˜๋„๋ก ๋ณ€๊ฒฝ๋˜์—ˆ์Šต๋‹ˆ๋‹ค. ์ž„์ƒ์˜ ์˜๊ฒฌ(์–‘์„ฑ)๊ณผ ์ง€์นจ(์•…์„ฑ) ์ค‘ ์–ด๋–ค ๊ธฐ์ค€์œผ๋กœ ์•”๋“ฑ๋ก ํ•ด์•ผํ• ์ง€ ๋‹ต๋ณ€ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๋ถ€์‚ฐ๋Œ€ํ•™๊ต๋ณ‘์› ๋ณด๊ฑด์˜๋ฃŒ์ •๋ณดํŒ€(051-240-7522~23)
[WHO Classification of Tumours Central Nervous System Tumours 5th edition] p.406 ์—์„œ ์ œ์‹œํ•˜๋Š” ์ฝ”๋“œ๋Š” M8272/3(Pituitary adenoma/PITUITARY NEUROENDOCRINE TUMOR) ๊ฐ€ ์žˆ์Šต๋‹ˆ๋‹ค.์กฐ์งํ•™์ ์ง„๋‹จ์ด 'Pituitary adenoma' ์œผ๋กœ ์ง„๋‹จ๋œ ๊ฒฝ์šฐ๋Š” M8272/0 ์œผ๋กœ,'Pituitary adenoma/pituitary neuroendocrine tumour' ๋กœ ์ง„๋‹จ๋œ ๊ฒฝ์šฐ๋Š” M8272/3 ์œผ๋กœ ๋“ฑ๋กํ•˜๋ผ๋Š” ์ค‘์•™์•”๋“ฑ๋ก๋ณธ๋ถ€์—์„œ๋Š” ๋‹ต๋ณ€์„ ๋“œ๋ฆฌ๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค.์ด๋ฅผ ๊ทผ๊ฑฐ๋กœ ํ•ด๋‹น ์ผ€์ด์Šค์˜ ์•…์„ฑ์—ฌ๋ถ€๋ฅผ ์ฃผ์น˜์˜ ์„ ์ƒ๋‹˜๊ป˜ ๋‹ค์‹œ ํ•œ๋ฒˆ ํ›„ ์•”๋“ฑ๋ก ํ•ด์ฃผ์‹œ๊ธฐ ๋ฐ”๋ž๋‹ˆ๋‹ค.
๋ณ‘๋ฆฌ-๋Œ€์žฅ(Colon- malignant tumor, Resection ) ํ•œ ๊ฒฐ๊ณผREVISED DIAGNOSIS Feb. 8, 2024Small intestine, terminal ileum, and large intestine, ascending, with cecum and vermiform appendix, continuous segment of, laparoscopic right hemicolectomy; 1) Tubulovillous adenocarcinoma, multifocal, lamina propria, (depth; 0.1 cm.), associated with tubular adenoma with high grade dysplasia(pTis) 2) Flat tubular adenoma 3) Lymphoid hyperplasia, vermiform appendix 4) Reactive hyperplasia (0/2 no tumor metastasis)(pN0)ํŒ๋…๋˜์—ˆ๋Š”๋ฐ /3(malignant) ๋กœ ๋“ฑ๋กํ•˜๋Š”๊ฒŒ ๋งž๋Š”์ง€ /2(in situ) ๋กœ ๋“ฑ๋กํ•˜๋Š”๊ฒŒ ๋งž๋Š”์ง€ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค.
ํ•ด๋‹น์ผ€์ด์Šค๋Š” C18._ M8263/2, SEERCODE: 1 ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.์•”๋“ฑ๋ก์‹œ [bigo] ํ•ญ๋ชฉ์— bx ๊ฒฐ๊ณผ ๊ธฐ์žฌํ•ด์ฃผ์„ธ์š”.
ํƒ€๋ณ‘์›์—์„œ 2018.10.4 ๋‡Œ์ˆ˜๋ง‰์ข…์œผ๋กœ ์ˆ˜์ˆ ํ•˜๊ณ  ์ตœ๊ทผ ์ฆ์ƒ๋ฐœํ˜„ํ•˜์—ฌ MRI์ƒ ์•…์„ฑ ์žฌ๋ฐœ๋กœ ๋ณธ์›์— ์ „์›, 2023.10.13 ์ˆ˜์ˆ  ์กฐ์ง๊ฒฐ๊ณผ Anaplastic Meningioma ์ž…๋‹ˆ๋‹ค.์ดˆ์ง„๋…„์›”์ผ์„ ์ตœ์ดˆ์ง„๋‹จ์œผ๋กœ ์ ์šฉํ•˜๋ฉด ์กฐ์งํ•™์ ์ง„๋‹จ๋ช… ์ ์šฉ์€ ํ˜„์žฌ ์‹œ์ ์œผ๋กœ ๋“ฑ๋กํ•ด๋„ ๋ฉ๋‹ˆ๊นŒ?
ํ•ด๋‹น์ผ€์ด์Šค๋Š” ์ดˆ์ง„์ผ: 2018.10.14. / M9530/0(Meningioma) ๋กœ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
๊ฒŒ์‹œ๊ธ€ ๋ฒˆํ˜ธ 2722์— ์งˆ๋ฌธ์— see note๋ฅผ ์ฒจ๋ถ€ํ•˜๋ผ๋Š” ๋‹ต๋ณ€์ด ์žˆ์œผ์…”์„œ ๋‹ค์‹œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๋ง์”€ํ•˜์‹  see note์—๋Š” ์™ธ๋ถ€์ž๋ฌธ ๊ต์ˆ˜๋‹˜ ์„ฑํ•จ๋งŒ ์žˆ์„ ๋ฟ ๋‹ค๋ฅธ ์ถ”๊ฐ€์ ์ธ ๋‚ด์šฉ์ด ์—†์Šต๋‹ˆ๋‹ค. T^T M code์— ๋Œ€ํ•œ ๋‹ต๋ณ€ ๋ฏธ๋ฆฌ ๊ฐ์‚ฌ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ================== ์ดํ•˜ ์ด์ „ ์งˆ๋ฌธ (๊ฒŒ์‹œ๊ธ€ 2722) ๋‚ด์šฉ =================== . M-code ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ^^ Nasal cavity Cancer๋กœ nasal OP ํ›„ ๋‚˜์˜จ ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ๋Š” ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค. Nasal cavity, right, excision: Hybrid carcinoma of myoepithelial carcinoma and squamous cell carcinoma (see note) with involved excisional margin NOTE : ์™ธ๋ถ€์ž๋ฌธ (o o ๋ณ‘์› Prof.o o o) ํ›„ ๊ฒฐ๊ณผ์ž…๋‹ˆ๋‹ค. ์œ„ ๊ฒฐ๊ณผ์™€ ๊ฐ™์€ ์กฐํ•ฉ์ฝ”๋“œ๊ฐ€ ์—†์–ด์„œ M8982/3 (Myoepithelial carcinoma) , M8070/3(Squamous cell carcinoma, NOS) ๊ฐ๊ฐ ๋“ฑ๋ก์„ ํ•˜๋ฉด๋ ๊นŒ์š” ? ๋‹ต๋ณ€ ๋ฏธ๋ฆฌ ๊ฐ์‚ฌ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ^^
ํ•ด๋‹น์ผ€์ด์Šค๋Š” M8010/3(carcinoma) ๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
๋ณ‘๋ฆฌ๊ฒฐ๊ณผ ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค.๊ธฐ์กด์— ๋‹ค๋ฅธ๋ถ„๋“ค์ด ๋ฌธ์˜ํ•˜์…จ๋˜ ๋‚ด์šฉ์„ ๋ฐ”ํƒ•์œผ๋กœ,์ด ๊ฒฝ์šฐ ์›๋ฐœ C25.4์— M8150/3 ์ด ์•„๋‹Œ,C25.2 M8240/3์œผ๋กœ ์•”๋“ฑ๋ก ํ•˜๋„๋ก ํ™•์ธ ๋˜๋Š”๋ฐ์š”Tumor -Neuroendocrine --grade I --grad II --grade III --pancreatic์ธ๋ฑ์Šค์—์„œ๋Š” ์œ„์™€๊ฐ™์ด grade์— ๋”ฐ๋ฅธ ๋‚ด์šฉ๊ณผ, pancreatic์ด ๊ฐ™์€ ๋ ˆ๋ฒจ๋กœํ•˜์œ„ ๋ถ„๋ฅ˜๋˜๊ณ  ์žˆ์–ด, ๋ถ„๋ฅ˜์— ํ˜ผ๋™์ด ์žˆ์Šต๋‹ˆ๋‹ค. ํ˜น์‹œ ์›๋ฐœ C25.4์™€ ์กฐ์งํ•™์  ์ง„๋‹จ M8150/3์€ ์–ธ์ œ ๋ถ„๋ฅ˜ํ•  ์ˆ˜ ์žˆ๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.pancreatic ํ•˜์œ„ ๋ถ„๋ฅ˜๋กœ ํ™•์ธ๋˜๋Š” nonfunctioning์ด ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ ๋ช…์‹œ๋œ ๊ฒฝ์šฐ์—๋งŒ ๋ถ„๋ฅ˜ํ•˜๋Š” ๊ฑด์ง€, ๋ถ€์œ„์ ์œผ๋กœ islets of langerhans์ธ ๊ฒฝ์šฐ์— ๋ถ„๋ฅ˜ํ•  ์ˆ˜ ์žˆ๋Š”๊ฑด์ง€..์ฐจ์ด๋ฅผ ๋ช…ํ™•ํžˆ ์•Œ๊ณ ์‹ถ์–ด ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.Pancreas and gallbladder , distal pancreatectomy and cholecystectomy; Neuroendocrine tumor, grade 1 - Location of the tumor: tail - Size of the tumor: 1x0.9x0.7cm - Depth of invasion: limited to the pancreas - Bile duct invasion: not evaluable - Duodenum invasion: not evaluable - Portal vein invasion: not evaluable - Hepatic artery invasion: not evaluable - Surgical margin(s): free from tumor - Safety margin(s): - Pancreatic duct: 2.2cm - Retroperitoneal: 0.4cm - Lymph node(s): No metastasis in 1 lymph node(s) (0/1) (pN0) - pericystic LN (0/1) - Lymphatic invasion: not identified - Venous invasion: not identified - Perineural invasion: not identified - Precancerous lesion: not identified - Pathologic staging: pT1bN0 - Associated finding(s): Not identified - Separate lesion(s): Not identified - Other organ(s): - Gallbladder: Cholelithiasis, Chronic cholecystitis, Cholesterol polyp
๋‹ต๋ณ€1) M8150/3 ์ฝ”๋“œ์˜ ์ •์˜๋Š” 'Pancreatic neuroendocrine tumor, nonfunctioning(C25.4)' ์œผ๋กœ 'nonfunctioning' ์šฉ์–ด๋กœ ์„ธ๋ถ„๋ฅ˜๋˜๊ณ  ๋ถ€์œ„ ๋˜ํ•œ C25.4(Islets of Langerhans)๋กœ ๋ถ„๋ฅ˜๋œ ๊ฒฝ์šฐ์—๋งŒ ํ•ด๋‹น ์ฝ”๋“œ๋ฅผ ๋ถ€์—ฌํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.๋‹ต๋ณ€2) ํ•ด๋‹น์ผ€์ด์Šค๋Š” M8240/3(Neuroendocrine tumor, grade 1)๋กœ ์•”๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
์ˆ˜๊ณ  ๋งŽ์œผ์‹ญ๋‹ˆ๋‹ค ๋ณต๋ถ€ํŒฝ๋งŒ๊ฐ์œผ๋กœ ๋‚ด์›ํ•˜์—ฌ ์‹œํ–‰ํ•œ CT๊ฒ€์‚ฌ์ƒ R/O Pancreas adenocarcinoma, metastases, peritoneal seeding ํ™•์ธ๋˜๋‚˜, ์กฐ์ง๊ฒ€์‚ฌ๊ฒฐ๊ณผ ์‹œํ–‰ํ•˜์ง€ ์•Š์€ ์ƒํƒœ์ž…๋‹ˆ๋‹ค. ์›๋ฐœ๋ถ€์œ„ : C80.9SEER stage : 9. ์ „์ด๋ถ€์œ„ : ๋“ฑ๋กํ•˜์ง€ ์•Š์Œ์ž„์ƒ๊ฒ€์‚ฌ๋กœ ์ „์ด๋ถ€์œ„ ํ™•์ธ๋˜๋‚˜, ์›๋ฐœ๋ถ€์œ„ ๋ฏธ์ƒ์ผ๋•Œ ์ „์ด๋ถ€์œ„๋Š” ๋“ฑ๋กํ•˜์ง€ ์•Š๋Š”๊ฒƒ์ด ๋งž๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
ํ•ด๋‹น์ผ€์ด์Šค๋Š” ์ž„์ƒ์ ์œผ๋กœ ์•…์„ฑ์•”์œผ๋กœ ํ™•์ง„์ด ๋œ ๊ฒฝ์šฐ์ธ์ง€ ๋จผ์ € ํ™•์ธ์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค.๊ทธ๋ฆฌ๊ณ  ์ „์ด๋ถ€์œ„์ฝ”๋”ฉ์€ SEERCODE ๊ฐ€ '7' ์ธ ๊ฒฝ์šฐ์—๋งŒ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.์›๋ฐœ๋ถ€์œ„๊ฐ€ C80.9 ์ธ ๊ฒฝ์šฐ๋Š” SEERCODE ๊ฐ€ '9' ๊ฐ’๋งŒ ์˜ฌ ์ˆ˜ ์žˆ์œผ๋ฏ€๋กœ, ์ „์ด๋ถ€์œ„๋Š” ๋“ฑ๋กํ•˜์ง€ ์•Š์Šต๋‹ˆ๋‹ค.
. ํƒ€๋ณ‘์›์—์„œ ์šฐ์ธก ํ—ˆ๋ฒ…์ง€ Dermatofibrosarcoma protuberans ๋กœ 3ํšŒ ์ˆ˜์ˆ  ํ›„ ๋ณธ์›์— ๋‚ด์›ํ•œ ํ™˜์ž์— ๋Œ€ํ•ด ์ฝ”๋“œ์™€ ๋ชฐํด๋กœ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.1.2023/6/26 ํƒ€๋ณ‘์›๊ฒฐ๊ณผ์ง€[ DIAGNOSIS ]Skin and subcutaneous tissue, thigh, right, excisional biopsy; Dermatofibrosarcoma protuberans2.2024/1/23 ๋ณธ์› wide excision bx ๊ฒฐ๊ณผ[ DIAGNOSIS ]Soft tissue, thigh, right, wide excision; Leiomyosarcoma, recurrent with 1. Post-excision status 2. Tumor size: 0.7x0.4x1.8cm 3. Anatomic sites: thigh, subcutaneous 4. Resection margin: free from carcinoma 5. Lymph node: not submitted 6. FNCLCC system grade: 2 - Tumor differentiation: 2 - Mitotic count: 2 (16/10HPF) - Tumor necrosis: 0์ธ ๊ฒฝ์šฐ, ๋ณธ์›์—์„œ๋Š” ๋ฏธ์ƒ์•”์˜ ์žฌ๋ฐœ๋กœ ์ฝ”๋“œ๋ฅผ ๋ถ€์—ฌํ•ด์•ผํ• ์ง€, ์•…์„ฑ์•”์œผ๋กœ ์ฝ”๋“œ๋ฅผ ๋ถ€์—ฌํ•ด์•ผ ํ• ์ง€ ํ•˜๋‹จ ๊ธฐ์žฌํ•œ ์„ธ๊ฐ€์ง€ ์ฝ”๋“œ ์ค‘ ์ฝ”๋“œ ๋ถ€์—ฌํ•  ์ˆ˜ ์žˆ์„์ง€ ๋ฌธ์˜ ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๋˜ํ•œ Leiomyosarcoma ๊ฐ€ ํ”ผ๋ถ€์—์„œ ๋ฐœ๊ฒฌ๋˜์—ˆ์„ ๋•Œ๋Š” M8897/1 ๋กœ ๋ถ„๋ฅ˜๋˜๋Š”๋ฐ ์ด๋ฒˆ ๊ฒฝ์šฐ์—๋„ M8897/1 ๋กœ ๋ถ„๋ฅ˜ํ•  ์ˆ˜ ์žˆ๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.1) D48.5 Neoplasm of uncertain or unknown behavior of skin M8832/1 Dermatofibrosarcoma protuberans NOS (M8832/1) U99 Recurrent malignant neoplasm2) C49.2 Malignant neoplasm of connective and soft tissue of lower limb, including hip M8890/3 Leiomyosarcoma NOS (M8890/3) U99 Recurrent malignant neoplasm3) D48.5 Neoplasm of uncertain or unknown behavior of skin M8897/1 Smooth muscle tumour of uncertain malignant potential (M8897/1) U99 Recurrent malignant neoplasm
์ดˆ์ง„์ผ์€ '์•…์„ฑ์•”์œผ๋กœ ๋ณธ์› ์ฒซ ๋‚ด์›์ผ', M8890/3(Leiomyosarcoma) ๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.
, SEER ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.1. ์™ผ์ชฝ ์‹ ์žฅ์•” ํ™˜์ž์ด๋ฉฐ CT๊ฒ€์‚ฌ๊ฒฐ๊ณผ์™€ ์˜์‚ฌ๊ธฐ๋ก์—์„œ ๊ฐ™์€์ชฝ Adrenal gland meta๋กœ ๊ธฐ์žฌ๋˜์–ด์žˆ์Šต๋‹ˆ๋‹ค. Extension์˜ ๊ฒฝ์šฐ SEER 2์— ํ•ด๋‹นํ•˜๋Š” ๊ฒฝ์šฐ์ด์ง€๋งŒ(๋‹ค๋ฅธ meta๋ถ€์œ„๊ฐ€ ์—†๋‹ค๊ณ  ๊ฐ€์ •์‹œ), ์•„๋ž˜์™€ ๊ฐ™์ด Left adrenal gland meta๋กœ ๊ธฐ์žฌ๋œ ๊ฒฝ์šฐ ์ „์ด๋ถ€์œ„๋กœ ๋ณผ์ˆ˜ ์žˆ๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.[CT,Abdomen & Pelvis ]1. About 9.2 cm ill-defined lobulated heterogeneously enhancing mass in left kidney.-- Renal cell carcinoma (T4, N0/1, M1) with peritoneal seeding, adrenal and lung metastases and direct colon invasion.2. A 1.7 cm well-defined nodule in left adrenal gland.-- r/o metastasis3. Multiple variable sized lung metastases up to 2 cm.[์˜์‚ฌ๊ธฐ๋ก]#1. clear cell RCC, Lt, sarcomatoid change(+)multiple lung metstases, Lt adrenal metastasis, peritoneal seeding, direct colon invasion--------------------------------------------------------------------2. ์œ„์•”ํ™˜์ž์ด๋ฉฐ duodenum meta๋กœ ์˜์‚ฌ๊ธฐ์žฌํ•˜์˜€์Šต๋‹ˆ๋‹ค.SEER์ฑ…์ž ์ฐธ๊ณ ์‹œ Duodenum์€ Extension๋ถ€์œ„์— ํ•ด๋‹นํ•˜์ง€๋งŒ, ์˜์‚ฌ๊ฐ€ meta๋กœ ๊ธฐ์žฌ์‹œ์—์›๊ฒฉ์ „์ด๋ถ€์œ„๋กœ ์ฝ”๋“œ๋ถ„๋ฅ˜ํ•  ์ˆ˜ ์žˆ๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.[์˜์‚ฌ๊ธฐ๋ก] AGC c duodenum meta, liver meta.Bx: Stomach, ( antrum, lesser curvature ) :- ADENOCARCINOMA, POORLY DIFFERENTIATED..Bx: Small intestine, ( duodenum ):- ADENOCARCINOMA, MODERATELY DIFFERENTIATED---------------------------------------------------------------------------3. ํ์•” ํ™˜์ž์ด๋ฉฐ ํ•ญ์•”, ๋ฐฉ์‚ฌ์„  ์น˜๋ฃŒํ–ˆ์Šต๋‹ˆ๋‹ค. CT,PET/CT๊ฒ€์‚ฌ ๊ฒฐ๊ณผ 'RUL invasion to RLL, RUL with transfissural extension to RLL'๋ฅผ ๊ทผ๊ฑฐ๋กœ SEER 3์œผ๋กœ ๋ถ„๋ฅ˜ํ•˜๋Š”์ง€, SEER 7๋กœ ๋ถ„๋ฅ˜ํ•˜๋Š”์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. (LN์€ ์˜์ƒ๊ฒ€์‚ฌ์ƒ regional LN meta๋กœ ํ™•์ธ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.)[์˜์‚ฌ๊ธฐ๋ก] RUL, ADC, T3N2M0.Bx: Lung, (right upper lobe):ADENOCARCINOMA[CT, chest]: About 6.1cm sized spiculated mass in RUL with invasion to RLL, Enlarged LN in the right hilar/interlobar station - R/O lung cancer(T3 N1)[PET/CT]: Hypermetabolic mass in RUL with transfissural extension to RLL: biopsy proven lung cancer๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
๋‹ต1) ์ „์ด๋ถ€์œ„์— adrenal gland ์ฝ”๋“œ๋ฅผ ๋“ฑ๋กํ•˜๋Š” ๊ฑด์ง€๊ฐ€ ๊ถ๊ธˆํ•˜์‹  ๊ฑธ๊นŒ์š”? 1๋ฒˆ์˜ ์ผ€์ด์Šค๋Š” SEERCODE ๋Š” '7' ๋ฒˆ์ด๊ณ , MEATACODE๋Š” ์›๊ฒฉ์ „์ด์— ํ•ด๋‹น๋˜๋Š” 'C349, C482' ๋งŒ ๋“ฑ๋กํ•˜๋ฉด ๋ฉ๋‹ˆ๋‹ค.๋‹ต2) ์˜์‚ฌ๋Š” meta ์™€ extension ์šฉ์–ด๋ฅผ ํ˜ผ์šฉํ•ด์„œ ์‚ฌ์šฉํ•˜๋Š” ๊ฒฝ์šฐ๊ฐ€ ๋งŽ์•„, direct extension(invasion) ์ธ์ง€ distant metastasis ์ธ์ง€๋Š” ์˜์ƒ๊ฒ€์‚ฌ ๊ฒฐ๊ณผ๋ฅผ ์ฐธ๊ณ ํ•ด์•ผ ํ•ฉ๋‹ˆ๋‹ค. ๋‹ต3) SEERCODE 7๋ฒˆ์ž…๋‹ˆ๋‹ค. (๊ทผ๊ฑฐ: SEER Summary Staging Manual 2000, p.151 - 7๋ฒˆ: Separate tumor nodule(s) in different lobe)
, ์œ„์•” morphology ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ์œ„์•” ESD ๋ณ‘๋ฆฌ๊ฒฐ๊ณผ์ž…๋‹ˆ๋‹ค. A) Stomach (high body), endoscopic submumocsal dissection: Gastric carcinoma with lymphoid stroma B) Stomach (distal antrum), endoscopic submucosal dissection: Tubular adenocarcinoma, Moderately differentiated๋ณธ์› ๋ณ‘๋ฆฌ์˜์‚ฌ์—๊ฒŒ ๋ฌธ์˜ํ•œ ๊ฒฐ๊ณผ Gastric carcinoma with lymphoid stroma ๋Š” lymphothelial carcinoma (8082/3)์™€ ๊ฐ™์€ ๋ณ‘๋ฆฌ๋กœ ๋ณธ๋‹ค๊ณ  ํ•ฉ๋‹ˆ๋‹ค. ์•”๋“ฑ๋ก ๊ต์œก์„ผํ„ฐ์—์„  Gastric carcinoma with lymphoid stroma๋ฅผ 8512/3์œผ๋กœ ๋“ฑ๋กํ•˜๋ผ๊ณ  ๋‹ต๋ณ€์ด ๋˜์–ด์žˆ์Šต๋‹ˆ๋‹ค. 1)Gastric carcinoma lymphoid stroma๋ฅผ 8082/3์œผ๋กœ ๋ณด๊ณ  Tubular adenocarcinoma 8211/3๊ณผ ๋‹ค๋ฅธ ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์— ์†ํ•˜๋ฏ€๋กœ ๋‹ค์ค‘์›๋ฐœ์•”์œผ๋กœ ๋“ฑ๋กํ•˜๋Š”์ง€2)Gastric carcinoma lymphoid stroma๋ฅผ 8512/3์œผ๋กœ ๋ณด๊ณ  8211/3๊ณผ ๊ฐ™์€ ์กฐ์ง์†Œ๊ฒฌ๊ตฐ์— ์†ํ•˜๋ฏ€๋กœ ํ•˜๋‚˜์˜ ์•”์œผ๋กœ ๋“ฑ๋กํ•ด์•ผํ•˜๋Š”์ง€๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
A)๋Š” M8512/3, B)๋Š” M8211/3 ์œผ๋กœ ๋™์ผ์กฐ์ง์†Œ๊ฒฌ๊ตฐ(3๊ทธ๋ฃน)์— ํ•ด๋‹นํ•ฉ๋‹ˆ๋‹ค. ๋”ฐ๋ผ์„œ M8512/3 ์œผ๋กœ ํ•˜๋‚˜๋งŒ ๋“ฑ๋กํ•ฉ๋‹ˆ๋‹ค.
,Urinary bladder TURBNON-INVASIVE PAPILLARY UROTHELIAL CARCINOMA, high grade ์†Œ๊ฒฌํ™•์ธ๋˜์—ˆ์Šต๋‹ˆ๋‹ค.D09.0 M8130/2 ๋กœ ์ง„๋‹จ๋ช…๊ณผ ๋ชฐํด๋กœ์ง€ ๋ถ€์—ฌํ•˜๋Š”๊ฒŒ ๋งž์„๊นŒ์š”?
C67._ M8130/2 ๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.
~ ๋งŽ์ด ๋ฐ”์˜์‹œ๊ฒ ์ง€๋งŒ ์•”๋“ฑ๋ก ์›๋ฐœ ๋ฐ ๋ชฐํด๋กœ์ง€ ๋ฌธ์˜ ๋‹ต๋ณ€์ฃผ์‹œ๋ฉด๊ฐ์‚ฌํ•˜๊ฒ ์Šต๋‹ˆ๋‹ค.DIAGNOSIS>Soft tissue,(masseter area, Rt) needle biopsy : High grade carcinoma with focal gland formation Others:<>Her-2: Equivocal(score 2/0-3)p40, p63, CK5/6, S-100, TTF-1, CD117: negative-------------------------------------------------------------PET CT>๊ฒ€์‚ฌ๋ช… : Torso PET-CT[Finding] [Conclusion]r/o Rt maxillary sinus cancerGlucose : 130 mg/dlํ‚ค: 171 cm ๋ชธ๋ฌด๊ฒŒ: 72 kg ๊ธˆ์‹์‹œ๊ฐ„: 9 hr ์ฃผ์‚ฌ๋ถ€์œ„: Lt forearm272 MBq์˜ F-18 FDG๋ฅผ ์ •๋งฅ์ฃผ์‚ฌํ•˜๊ณ  basal skull๋ถ€ํ„ฐ mid-thigh ๋ถ€์œ„๊นŒ์ง€ CT๋กœ ๋ณด์ •ํ•˜์—ฌ PET์˜์ƒ์„ ์–ป์—ˆ์Œ.Right maxillary sinus์™€ zygomatic bone, maxilla, masticator space๋ฅผ involving ํ•˜๋Š” hypermetabolic soft-tissue๊ฐ€ ๊ด€์ฐฐ๋˜๊ณ  ์žˆ์œผ๋ฉฐ SUVmax=11.6์˜ FDG ์„ญ์ทจ์ฆ๊ฐ€๋ฅผ ๋ณด์ž„. Malignancy ์†Œ๊ฒฌ์ž„.๋˜ํ•œ mandible๊ณผ right parotid space์—๋„ SUVmax=8.2 ๋“ฑ์˜ FDG ์„ญ์ทจ์ฆ๊ฐ€๋ฅผ ๋ณด์ด๋Š” hypermetabolic lesion๋“ค์ด ๊ด€์ฐฐ๋˜๋ฉฐ ์ด ์—ญ์‹œ malignancy ์†Œ๊ฒฌ์ž„.Right neck level II/III lymph node์— SUVmax=2.9์˜ FDG ์„ญ์ทจ์ฆ๊ฐ€๊ฐ€ ๋ณด์ด๋Š”๋ฐ metastatic lymphadenopathy์ผ ๊ฐ€๋Šฅ์„ฑ์„ ์™„์ „ํžˆ ๋ฐฐ์ œํ•  ์ˆ˜ ์—†๊ฒ ์Œ.Left lung upper lobe์— pulmonary nodule์ด ๊ด€์ฐฐ๋˜๋Š”๋ฐ ์œ ์˜ํ•œ FDG ์„ญ์ทจ์ฆ๊ฐ€๋Š” ๋ณด์ด์ง€ ์•Š์Œ.๊ทธ ๋ฐ–์˜ ์ „์‹ ์˜์ƒ์—์„œ ์•…์„ฑ์„ ์˜์‹ฌํ•  ๋งŒํ•œ ๋น„์ •์ƒ์ ์ธ FDG ์„ญ์ทจ์ฆ๊ฐ€๋Š” ๋ณด์ด์ง€ ์•Š์Œ.Conclusion)1. Hypermetabolic soft-tissue involving right maxillary sinus, zygomatic bone, maxilla and masticator space. Hypermetabolic lesion in the right mandible and parotid space, highly suggestive of malignancy.2. Mild FDG uptake in the right neck level II/III lymph node, r/o metastatic lymphadenopathy.3. Small pulmonary nodule in the left lung upper lobe without significant FDG uptake.Question >1. ์ƒํ™˜ ์•”๋“ฑ๋ก ์›๋ฐœ์„ C49.0 ์œผ๋กœ ํ•˜๊ณ  ๋ชฐํด๋กœ์ง€ M8010/3 ์œผ๋กœ ํ•ด์•ผํ• ์ง€2. C31.8 ์œผ๋กœํ•˜๊ณ  ๋ชฐํด๋กœ์ง€ M8010/3 ์œผ๋กœ ํ•ด์•ผํ• ์ง€ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค. ํ˜น์‹œ morphology๋„ ๋‹ค๋ฅธ ์˜๊ฒฌ์ด ์žˆ์œผ์‹œ๋ฉด ๊ณ ๊ฒฌ ๋ถ€ํƒ๋“œ๋ฆฝ๋‹ˆ๋‹ค. ๊ฐ์‚ฌํ•ฉ๋‹ˆ๋‹ค.
ํ•ด๋‹น ์ผ€์ด์Šค๋Š” C76.0(Head, face or neck, NOS) M8010/3(Carcinoma) ๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.
๋ฆผํ”„์ ˆ ์กฐ์ง๊ฒ€์‚ฌ ์‹œํ–‰ํ•˜์—ฌ ์•„๋ž˜์™€ ๊น‰์ด ๋‚˜์™”๋Š”๋ฐ ๋ชฐํด๋กœ์ง€ ์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค Lymph node, axilla, left, excision: Malignant lymphoma, NK-cell lineage lymphoma (see note). * Note: 1. Differential diagnosis includes 1) Nodal EBV-positive NK-cell lymphoma and 2) extranodal NK/T-cell lymphoma.Additional Result Key block: Lymph node (resection) Tumor cell percentage: 75% Organ: Lymph node (resection) Tumor type: Non-Hodgkin lymphoma Pathologic diagnosis: EBV+ Nodal T-and NK-cell lymphomaEBV+ Nodal T-and NK-cell lymphoma ๋ชฐํด๋กœ์ง€ ์ฝ”๋“œ ๋ฌธ์˜๋“œ๋ฆฝ๋‹ˆ๋‹ค.
M9719/3(T/NK-cell lymphoma) ๋กœ ์ฝ”๋”ฉํ•ฉ๋‹ˆ๋‹ค.
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