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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ketoconazole: Ketoconazole may inhibit both synthetic and catabolic enzymes of vitamin D. | <Ketoconazole, mechanism, vitamin D> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Corticosteroids: A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. | <vitamin D analogues, mechanism, corticosteroids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Magnesium: Magnesium-containing preparations (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with vitamin D by patients on chronic renal dialysis. | <Magnesium, advise, vitamin D>, <antacids, advise, vitamin D> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | ERGAMISOL (levamisole hydrochloride) has been reported to produce ANTABUSE-like side effects when given concomitantly with alcohol. | <ERGAMISOL, effect, alcohol>, <levamisole hydrochloride, effect, alcohol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Because of reports of prolongation of the prothrombin time beyond the therapeutic range in patients taking concurrent levamisole and warfarin sodium, it is suggested that the prothrombin time be monitored carefully, and the dose of warfarin sodium or other coumarin-like drugs should be adjusted accordingly, in patients taking both drugs. | <levamisole, advise, warfarin sodium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Use with Allopurinol: The principal pathway for detoxification of azathioprine is inhibited by allopurinol. | <azathioprine, mechanism, allopurinol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients receiving azathioprine and allopurinol concomitantly should have a dose reduction of azathioprine, to approximately 1/3 to 1/4 the usual dose. | <azathioprine, advise, allopurinol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Use with Angiotensln Converting Enzyme Inhibitors: The use of angiotensin converting enzyme inhibitors to control hypertension in patients on azathioprine has been reported to induce severe leukopenia. | <angiotensin converting enzyme inhibitors, effect, azathioprine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Alcohol - Although LEXAPRO did not potentiate the cognitive and motor effects of alcohol in a clinical trial, as with other psychotropic medications, the use of alcohol by patients taking LEXAPRO is not recommended. | <psychotropic medications, advise, LEXAPRO>, <alcohol, advise, LEXAPRO> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Epidemiological studies of the case-control and cohort design that have demonstrated an association between use of psychotropic drugs that interfere with serotonin reuptake and the occurrence of upper gastrointestinal bleeding have also shown that concurrent use of an NSAID or aspirin potentiated the risk of bleeding. | <psychotropic drugs, effect, NSAID>, <psychotropic drugs, effect, aspirin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cimetidine - In subjects who had received 21 days of 40 mg/day racemic citalopram, combined administration of 400 mg/day cimetidine for 8 days resulted in an increase in citalopram AUC and Cmax of 43% and 39%, respectively. | <citalopram, mechanism, cimetidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Because lithium may enhance the serotonergic effects of escitalopram, caution should be exercised when LEXAPRO and lithium are coadministered. | <lithium, effect, escitalopram>, <LEXAPRO, advise, lithium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Pimozide and Celexa - In a controlled study, a single dose of pimozide 2 mg co-administered with racemic citalopram 40 mg given once daily for 11 days was associated with a mean increase in QTc values of approximately 10 msec compared to pimozide given alone. | <pimozide, effect, citalopram> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Sumatriptan - There have been rare postmarketing reports describing patients with weakness, hyperreflexia, and incoordination following the use of a selective serotonin reuptake inhibitor (SSRI) and sumatriptan. | <selective serotonin reuptake inhibitor, effect, sumatriptan>, <SSRI, effect, sumatriptan> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If concomitant treatment with sumatriptan and an SSRI (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram, escitalopram) is clinically warranted, appropriate observation of the patient is advised. | <sumatriptan, advise, SSRI>, <sumatriptan, advise, fluoxetine>, <sumatriptan, advise, fluvoxamine>, <sumatriptan, advise, paroxetine>, <sumatriptan, advise, sertraline>, <sumatriptan, advise, citalopram>, <sumatriptan, advise, escitalopram> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although trough citalopram plasma levels were unaffected, given the enzyme-inducing properties of carbamazepine, the possibility that carbamazepine might increase the clearance of escitalopram should be considered if the two drugs are coadministered. | <carbamazepine, mechanism, escitalopram> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ketoconazole - Combined administration of racemic citalopram (40 mg) and ketoconazole (200 mg) decreased the Cmax and AUC of ketoconazole by 21% and 10%, respectively, and did not significantly affect the pharmacokinetics of citalopram. | <citalopram, mechanism, ketoconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, there are limited in vivo data suggesting a modest CYP2D6 inhibitory effect for escitalopram, i.e., coadministration of escitalopram (20 mg/day for 21 days) with the tricyclic antidepressant desipramine (single dose of 50 mg), a substrate for CYP2D6, resulted in a 40% increase in Cmax and a 100% increase in AUC of desipramine. | <escitalopram, mechanism, desipramine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Metoprolol - Administration of 20 mg/day LEXAPRO for 21 days in healthy volunteers resulted in a 50% increase in Cmax and 82% increase in AUC of the beta-adrenergic blocker metoprolol (given in a single dose of 100 mg). | <LEXAPRO, mechanism, metoprolol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concomitant Administration with Racemic Citalopram Citalopram - Since escitalopram is the active isomer of racemic citalopram (Celexa), the two agents should not be coadministered. | <escitalopram, advise, citalopram>, <escitalopram, advise, Celexa> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cytadren accelerates the metabolism of dexamethasone; | <Cytadren, mechanism, dexamethasone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Aminoglutethimide diminishes the effect of coumarin and warfarin. | <Aminoglutethimide, effect, coumarin>, <Aminoglutethimide, effect, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, appropriate monitoring of blood glucose should be performed when initiating EXTRANEAL in diabetic patients and insulin dosage should be adjusted if needed. | <EXTRANEAL, advise, insulin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The hypotensive effect of sodium nitroprusside is augmented by that of most other hypotensive drugs, including ganglionic blocking agents, negative inotropic agents, and inhaled anesthetics. | <sodium nitroprusside, effect, hypotensive drugs>, <sodium nitroprusside, effect, ganglionic blocking agents>, <sodium nitroprusside, effect, anesthetics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | CNS-Active Drugs Ethanol An additive effect on psychomotor performance was seen with coadministration of eszopiclone and ethanol 0.70 g/kg for up to 4 hours after ethanol administration. | <eszopiclone, effect, ethanol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Olanzapine: Coadministration of eszopiclone 3 mg and olanzapine 10 mg produced a decrease in DSST scores. | <eszopiclone, effect, olanzapine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The AUC of eszopiclone was increased 2.2-fold by coadministration of ketoconazole, a potent inhibitor of CYP3A4, 400 mg daily for 5 days. | <eszopiclone, mechanism, ketoconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Drugs That Induce CYP3A4 (Rifampicin) Racemic zopiclone exposure was decreased 80% by concomitant useof rifampicin, a potent inducer of CYP3A4. | <zopiclone, mechanism, rifampicin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. | <Clindamycin, effect, neuromuscular blocking agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antagonism has been demonstrated between clindamycin and erythromycin in vitro. | <clindamycin, effect, erythromycin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concomitant administration of other sympathomimetic agents may potentiate the undesirable effects of FORADIL. | <sympathomimetic agents, effect, FORADIL> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Monoamine Oxidase Inhibitors and Tricyclic Antidepressants: FORADIL should be administered with extreme caution in patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants because the action of formoterol on the cardiovascular system may be potentiated by these agents. | <FORADIL, advise, monoamine oxidase inhibitors>, <FORADIL, advise, tricyclic antidepressants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Corticosteroids, Methylxanthines and Diuretics: Concomitant treatment with xanthine derivatives, steroids, or diuretics may potentiate a possible hypokalemic effect of beta2-agonists. | <xanthine derivatives, effect, beta2-agonists.>, <steroids, effect, beta2-agonists.>, <diuretics, effect, beta2-agonists.> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | During administration of multiple oral doses of TAMBOCOR to healthy subjects stabilized on a maintenance dose of digoxin, a 13%-19% increase in plasma digoxin levels occurred at six hours postdose. | <TAMBOCOR, mechanism, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In a study involving healthy subjects receiving TAMBOCOR and propranolol concurrently, plasma flecainide levels were increased about 20% and propranolol levels were increased about 30% compared to control values. | <TAMBOCOR, mechanism, propranolol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The effects of concomitant administration of TAMBOCOR and propranolol on the PR interval were less than additive. | <TAMBOCOR, effect, propranolol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nevertheless, the possibility of additive negative inotropic effects of beta blockers and flecainide should be recognized. | <beta blockers, effect, flecainide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Limited data in patients receiving known enzyme inducers ( phenytoin, phenobarbital, carbamazepine ) indicate only a 30% increase in the rate of flecainide elimination. | <phenytoin, mechanism, flecainide>, <phenobarbital, mechanism, flecainide>, <carbamazepine, mechanism, flecainide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In healthy subjects receiving cimetidine (1 gm daily) for one week, plasma flecainide levels increased by about 30% and half-life increased by about 10%. | <cimetidine, mechanism, flecainide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When amiodarone is added to flecainide therapy, plasma flecainide levels may increase two-fold or more in some patients, if flecainide dosage is not reduced. | <amiodarone, mechanism, flecainide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Drugs that inhibit cytochrome P450IID6, such as quinidine , might increase the plasma concentrations of flecainide in patients that are on chronic flecainide therapy; | <quinidine, mechanism, flecainide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Because both of these drugs have negative inotropic properties and the effects of coadministration with TAMBOCOR are unknown, neither disopyramide nor verapamil should be administered concurrently with TAMBOCOR unless, in the judgment of the physician, the benefits of this combination outweigh the risks. | <disopyramide, advise, TAMBOCOR>, <verapamil, advise, TAMBOCOR> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Caution should be observed when anileridine is coadministered with other opioids, sedatives, phenothiazines, or anesthetics, as these agents may increase respiratory and circulatory depression. | <anileridine, advise, opioids>, <anileridine, advise, sedatives>, <anileridine, advise, phenothiazines>, <anileridine, advise, anesthetics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Vasoconstrictors: D.H.E. 45 (dihydroergotamine mesylate) Injection, USP should not be used with peripheral vasoconstrictors because the combination may cause synergistic elevation of blood pressure. | <D.H.E. 45, effect, peripheral vasoconstrictors>, <dihydroergotamine mesylate, effect, peripheral vasoconstrictors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Sumatriptan: Sumatriptan has been reported to cause coronary artery vasospasm, and its effect could be additive with D.H.E. 45 (dihydroergotamine mesylate) Injection, USP. | <Sumatriptan, effect, D.H.E. 45>, <Sumatriptan, effect, dihydroergotamine mesylate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Sumatriptan and D.H.E. 45 (dihydroergotamine mesylate) Injection, USP should not be taken within 24 hours of each other.. | <Sumatriptan, advise, D.H.E. 45>, <Sumatriptan, advise, dihydroergotamine mesylate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Beta Blockers: Although the results of a clinical study did not indicate a safe problem associated with the administration of D.H.E. 45 (dihydroergotamine mesylate) Injection, USP to subjects already receiving propranolol, there have been reports that propranolol may potentiate the vasoconstrictive action of ergotamine by blocking the vasodilating property of epinephrine. | <propranolol, effect, ergotamine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nicotine: Nicotine may provoke vasoconstriction in some patients, predisposing to a greater ischemic response to ergot therapy. | <Nicotine, effect, ergot> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Macrolide Antibiotics (e. g. erythromycin and troleandomycin): Agents of the ergot alkaloid class, of which D.H.E. 45 (dihydroergotamine mesylate) Injection, USP is a member, have been shown to interact with antibiotics of the macrolide class, resulting in increased plasma levels of unchanged alkaloids and peripheral vasoconstriction. | <ergot alkaloid class, mechanism, macrolide class>, <D.H.E. 45, mechanism, macrolide class>, <dihydroergotamine mesylate, mechanism, macrolide class> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Vasospastic reactions have been reported with therapeutic doses of ergotamine-containing drugs when co-administered with these antibiotics. | <ergotamine, effect, antibiotics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | SSRIs: Weakness hyperreflexia, and incoordination have been reported rarely when 5-HT1 agonists have been co-administered with SSRIs (e. g. | <5-HT1 agonists, effect, SSRIs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In a study in which patients with active RA were treated for up to 24 weeks with concurrent Kineret and etanercept therapy, a 7% rate of serious infections was observed, which was higher than that observed with etanercept alone (0%). | <Kineret, effect, etanercept> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Two percent of patients treated concurrently with Kineret and etanercept developed neutropenia (ANC 1 x 109/L). | <Kineret, effect, etanercept> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | With oral dapsone treatment, folic acid antagonists such as pyrimethamine have been noted to possibly increase the likelihood of hematologic reactions | <dapsone, effect, folic acid antagonists>, <dapsone, effect, pyrimethamine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Drugs That Should Not Be Coadministered With VIRACEPT Antiarrhythmics: amiodarone, quinidine Antihistamines: astemizole, terfenadine Antimigraine: ergot derivatives Antimycobacterial agents: rifampin Benzodiazepines midazolam, triazolam GI motility agents: cisapride | <VIRACEPT, advise, Antiarrhythmics>, <VIRACEPT, advise, amiodarone>, <VIRACEPT, advise, quinidine>, <VIRACEPT, advise, Antihistamines>, <VIRACEPT, advise, astemizole>, <VIRACEPT, advise, terfenadine>, <VIRACEPT, advise, ergot derivatives>, <VIRACEPT, advise, Antimycobacterial agents>, <VIRACEPT, advise, rifampin>, <VIRACEPT, advise, Benzodiazepines>, <VIRACEPT, advise, midazolam>, <VIRACEPT, advise, triazolam>, <VIRACEPT, advise, cisapride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Drugs Which Require a Dose Reduction When Coadminstered With VIRACEPT Antimycobacterial agents: rifabutin | <VIRACEPT, advise, Antimycobacterial agents>, <VIRACEPT, advise, rifabutin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | therefore, VIRACEPT should not be administered concurrently with terfenadine because of the potential for serious and/or life-threatening cardiac arrhythmias. | <VIRACEPT, advise, terfenadine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Because a similar interaction is likely, VIRACEPT should also not be administered concurrently with astemizole. | <VIRACEPT, advise, astemizole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Indinavir: Coadministration of indinavir with VIRACEPT resulted in an 83% increase in nelfinavir plasma AUC and a 51% increase in indinavir plasma A.C. | <indinavir, mechanism, VIRACEPT> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ritonavir: Coadministration of ritonavir with VIRACEPT resulted in a 152% increase in nelfinavir plasma AUC and very little change in ritonavir plasma A.C. | <ritonavir, mechanism, VIRACEPT> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Saquinavir: Coadministration of saquinavir (using an experimental soft-gelatin capsule formulation of saquinavir 1200mg) with VIRACEPT resulted in an 18% increase in nelfinavir plasma AUC and a 4-fold increase in saquinavir plasma A.C. | <saquinavir, mechanism, VIRACEPT> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ketoconazole: Coadministration of ketoconazole with VIRACEPT resulted in a 35% increase in nelfinavir plasma A.C. | <ketoconazole, mechanism, VIRACEPT> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | therefore, nelfinavir should be administered (with food) one hour after or more than two hours before didanosine. | <nelfinavir, advise, didanosine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | A dose adjustment is not needed when zidovudine is administered with VIRACEPT. | <zidovudine, advise, VIRACEPT> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Rifabutin: Coadministration of rifabutin and VIRACEPT resulted in a 32% decrease in nelfinavir plasma AUC and a 207% increase in rifabutin plasma A.C. | <rifabutin, mechanism, VIRACEPT> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It is recommended that the dose of rifabutin be reduced to one-half the usual dose when administered with VIRACEPT. | <rifabutin, advise, VIRACEPT> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Rifampin: Coadministration of rifampin and VIRACEPT resulted in an 82% decrease in nelfinavir plasma A.C. | <rifampin, mechanism, VIRACEPT> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | VIRACEPT and rifampin should not be coadministered. | <VIRACEPT, advise, rifampin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ethinyl Estradiol and Norethindrone: Coadministration of VIRACEPT with OVCON-35 resulted in a 47% decrease in ethinyl estradiol and an 18% decrease in norethindrone plasma concentrations. | <VIRACEPT, mechanism, OVCON-35> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In an in vitro study in human liver microsomes, inhibition of CYP2A6 hydroxylation of coumarin by fondaparinux (200 m m M i.e., 350 mg/L) was 17-28%. | <coumarin, mechanism, fondaparinux> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Taking a rauwolfia alkaloid while you are taking or within 2 weeks of taking MAO inhibitors may increase the risk of central nervous system depression or may cause a severe high blood pressure reaction. | <rauwolfia alkaloid, effect, MAO inhibitors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Tissue culture and animal studies indicate that ELSPAR can diminish or abolish the effect of methotrexate on malignant cells.14 This effect on methotrexate activity persists as long as plasma asparagine levels are suppressed. | <ELSPAR, effect, methotrexate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | These results would seem to dictate against the clinical use of methotrexate with ELSPAR, or during the period following ELSPAR therapy when plasma asparagine levels are below normal. | <methotrexate, advise, ELSPAR> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Metoclopramide: When coadministered with MONUROL, metoclopramide, a drug which increases gastrointestinal motility, lowers the serum concentration and urinary excretion of fosfomycin. | <MONUROL, mechanism, metoclopramide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Etonogestrel may interact with the following medications: acetaminophen (Tylenol), antibiotics such as ampicillin and tetracycline, anticonvulsants (Dilantin, Phenobarbital, Tegretol, Trileptal, Topamax, Felbatol), antifungals (Gris-PEG, Nizoral, Sporanox), atorvastatin (Lipitor), clofibrate (Atromid-S), cyclosporine (Neoral, Sandimmune), HIV drugs classified as protease inhibitors (Agenerase, Crixivan, Fortovase, Invirase, Kaletra, Norvir, Viracept), morphine (Astramorph, Kadian, MS Contin), phenylbutazone, prednisolone (Prelone), rifadin (rifampin), St. Johns wort, temazepam, theophylline (Theo-Dur), and vitamin C. | <Etonogestrel, int, acetaminophen>, <Etonogestrel, int, Tylenol>, <Etonogestrel, int, antibiotics>, <Etonogestrel, int, ampicillin>, <Etonogestrel, int, tetracycline>, <Etonogestrel, int, anticonvulsants>, <Etonogestrel, int, Dilantin>, <Etonogestrel, int, Phenobarbital>, <Etonogestrel, int, Tegretol>, <Etonogestrel, int, Trileptal>, <Etonogestrel, int, Topamax>, <Etonogestrel, int, Felbatol>, <Etonogestrel, int, antifungals>, <Etonogestrel, int, Gris-PEG>, <Etonogestrel, int, Nizoral>, <Etonogestrel, int, Sporanox>, <Etonogestrel, int, atorvastatin>, <Etonogestrel, int, Lipitor>, <Etonogestrel, int, clofibrate>, <Etonogestrel, int, Atromid-S>, <Etonogestrel, int, cyclosporine>, <Etonogestrel, int, Neoral>, <Etonogestrel, int, Sandimmune>, <Etonogestrel, int, protease inhibitors>, <Etonogestrel, int, Agenerase>, <Etonogestrel, int, Crixivan>, <Etonogestrel, int, Fortovase>, <Etonogestrel, int, Invirase>, <Etonogestrel, int, Kaletra>, <Etonogestrel, int, Norvir>, <Etonogestrel, int, Viracept>, <Etonogestrel, int, morphine>, <Etonogestrel, int, Astramorph>, <Etonogestrel, int, Kadian>, <Etonogestrel, int, MS Contin>, <Etonogestrel, int, phenylbutazone>, <Etonogestrel, int, prednisolone>, <Etonogestrel, int, Prelone>, <Etonogestrel, int, rifadin>, <Etonogestrel, int, rifampin>, <Etonogestrel, int, temazepam>, <Etonogestrel, int, theophylline>, <Etonogestrel, int, Theo-Dur>, <Etonogestrel, int, vitamin C> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | For example, when vitamin K antagonists are administered concomitantly with nilutamide, prothrombin time should be carefully monitored and if necessary, the dosage of vitamin K antagonists should be reduced. | <vitamin K antagonists, advise, nilutamide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In a study in which the 2 mg clonazepam orally disintegrating tablet was administered with and without propantheline (an anticholinergic agent with multiple effects on the GI tract) to healthy volunteers, the AUC of clonazepam was 10% lower and the Cmax of clonazepam was 20% lower when the orally disintegrating tablet was given with propantheline compared to when it was given alone. | <clonazepam, mechanism, propantheline>, <clonazepam, mechanism, propantheline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cytochrome P-450 inducers, such as phenytoin, carbamazepine and phenobarbital, induce clonazepam metabolism, causing an approximately 30% decrease in plasma clonazepam levels. | <phenytoin, mechanism, clonazepam>, <carbamazepine, mechanism, clonazepam>, <phenobarbital, mechanism, clonazepam> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although clinical studies have not been performed, based on the involvement of the cytochrome P-450 3A family in clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents, should be used cautiously in patients receiving clonazepam. | <antifungal agents, advise, clonazepam> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Pharmacodynamic Interactions: The CNS-depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs. | <benzodiazepine class, effect, alcohol>, <benzodiazepine class, effect, narcotics>, <benzodiazepine class, effect, barbiturates>, <benzodiazepine class, effect, nonbarbiturate hypnotics>, <benzodiazepine class, effect, antianxiety agents>, <benzodiazepine class, effect, phenothiazines classes of antipsychotic agents>, <benzodiazepine class, effect, thioxanthene classes of antipsychotic agents>, <benzodiazepine class, effect, butyrophenone classes of antipsychotic agents>, <benzodiazepine class, effect, monoamine oxidase inhibitors>, <benzodiazepine class, effect, tricyclic antidepressants>, <benzodiazepine class, effect, anticonvulsant drugs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Human growth hormone - Concomitant use of L-glutamine and human growth hormone may enhance nutrient absorption in those with severe short bowel syndrome. | <L-glutamine, mechanism, human growth hormone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Indomethacin - Concomitant use of L-glutamine and indomethacin may ameliorate increased intestinal permeability caused by indomethacin. | <L-glutamine, effect, indomethacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Methotrexate - There is one report that methotrexate may decrease the possible effectiveness of supplemental L-glutamine for chemotherapy-induced mucositis. | <methotrexate, effect, L-glutamine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In another report, nine patients with breast cancer were reported to have decreased symptoms of methotrexate-related toxicity when given supplemental L-glutamine at a dose of 0.5 gram/kilogram/day. | <methotrexate, effect, L-glutamine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Paclitaxel - In one report, L-glutamine at a dose of 10 grams three times daily, given 24 hours after receiving paclitaxel, appeared to prevent the development of myalgia and arthralgia, adverse reactions of paclitaxel. | <L-glutamine, effect, paclitaxel> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Fenfluramine may increase slightly the effect of antihypertensive drugs, e.g., guanethidine, methyldopa, reserpine. | <Fenfluramine, effect, antihypertensive drugs>, <Fenfluramine, effect, guanethidine>, <Fenfluramine, effect, methyldopa>, <Fenfluramine, effect, reserpine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Other CNS depressant drugs should be used with caution in patients taking fenfluramine, since the effects may be additive. | <CNS depressant drugs, advise, fenfluramine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, co administration of fexofenadine hydrochloride with either ketoconazole or erythromycin led to increased plasma concentrations of fexofenadine. | <fexofenadine hydrochloride, mechanism, ketoconazole>, <fexofenadine hydrochloride, mechanism, erythromycin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | These studies indicate that ketoconazole or erythromycin co-administration enhances fexofenadine gastrointestinal absorption. | <ketoconazole, mechanism, fexofenadine>, <erythromycin, mechanism, fexofenadine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | This observed increase in the bioavailability of fexofenadine may be due to transport-related effects, such as p-glycoprotein. in vivo animal studies also suggest that in addition to enhancing absorption, ketoconazole decreases fexofenadine gastrointestinal secretion, while erythromycin may also decrease biliary excretion. | <ketoconazole, mechanism, fexofenadine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Drug Interactions with Antacids Administration of 120 mg of fexofenadine hydrochloride (2 x 60 mg capsule) within 15 minutes of an aluminum and magnesium containing antacid (Maalox ) decreased fexofenadine AUC by 41% and cmax by 43%. | <fexofenadine hydrochloride, mechanism, aluminum>, <fexofenadine hydrochloride, mechanism, magnesium>, <fexofenadine hydrochloride, mechanism, antacid>, <fexofenadine hydrochloride, mechanism, Maalox> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | ALLEGRA should not be taken closely in time with aluminum and magnesium containing antacids. | <ALLEGRA, advise, aluminum>, <ALLEGRA, advise, magnesium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients receiving other narcotic analgesics, general anesthetics, phenothiazines, tranquilizers, sedative-hypnotics, tricyclic antidepressants or other CNS depressants (including alcohol) concomitantly with DILAUDID may exhibit an additive CNS depression. | <narcotic analgesic, effect, DILAUDID>, <anesthetics, effect, DILAUDID>, <phenothiazines, effect, DILAUDID>, <tranquilizers, effect, DILAUDID>, <sedative-hypnotics, effect, DILAUDID>, <tricyclic antidepressants, effect, DILAUDID>, <CNS depressants, effect, DILAUDID>, <alcohol, effect, DILAUDID> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antacid: When atorvastatin and Maalox TC suspension were coadministered, plasma concentrations of atorvastatin decreased approximately 35%. | <atorvastatin, mechanism, Maalox TC> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Colestipol: Plasma concentrations of atorvastatin decreased approximately 25% when colestipol and atorvastatin were coadministered. | <colestipol, mechanism, atorvastatin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, LDL-C reduction was greater when atorvastatin and colestipol were coadministered than when either drug was given alone. | <atorvastatin, effect, colestipol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Digoxin: When multiple doses of atorvastatin and digoxin were coadministered, steady-state plasma digoxin concentrations increased by approximately 20%. | <atorvastatin, mechanism, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Erythromycin: In healthy individuals, plasma concentrations of atorvastatin increased approximately 40% with coadministration of atorvastatin and erythromycin, a known inhibitor of cytochrome P450 3A4. | <atorvastatin, mechanism, erythromycin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Oral Contraceptives: Coadministration of atorvastatin and an oral contraceptive increased AUC values for norethindrone and ethinyl estradiol by approximately 30% and 20%. | <atorvastatin, mechanism, contraceptive>, <atorvastatin, mechanism, norethindrone>, <atorvastatin, mechanism, ethinyl estradiol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | These increases should be considered when selecting an oral contraceptive for a woman taking atorvastatin. | <contraceptive, advise, atorvastatin> |