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18,219,583 | {
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"DOI": "10.1080/08927010701730311",
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"url": "https://repositorium.sdum.uminho.pt/bitstream/1822/10363/1/Simoes_Biofouling.pdf"
} | The effect of the anionic surfactant sodium dodecyl sulfate (SDS) on Pseudomonas fluorescens biofilms was investigated using flow cell reactors with stainless steel substrata, under turbulent (Re = 5200) and laminar (Re = 2000) flow. Steady-state biofilms were exposed to SDS in single doses (0.5, 1, 3 and 7 mM) and biofilm respiratory activity and mass measured at 0, 3, 7 and 12 h after the SDS application. The effect of SDS on biofilm mechanical stability was assessed using a rotating bioreactor. Whilst high concentrations (7 mM) of SDS promoted significant biofilm inactivation, it did not significantly reduce biofouling. Turbulent and laminar flow-generated biofilms had comparable susceptibility to SDS application. Following SDS exposure, biofilms rapidly recovered over the following 12 h, achieving higher respiratory activity values than before treatment. This phenomenon of post-treatment recovery was more pronounced for turbulent flow-generated biofilms, with an increase in SDS concentration. The mechanical stability of the biofilms increased with surfactant application, except for SDS concentrations near the critical micellar concentration, as measured by biofilm removal due to an increase in external shear stress forces. The data suggest that although SDS exerts antimicrobial action against P. fluorescens biofilms, even if only partial and reversible, it had only limited antifouling efficacy, increasing biofilm mechanical stability at low concentrations and allowing significant and rapid recovery of turbulent flow-generated biofilms. | 2022-12-23T02:23:11.246Z |
216,219,465 | {
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"DOI": "10.7717/peerj-cs.266",
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"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.7717/peerj-cs.266"
} | Anti-forgery information, transaction verification, and smart contract are functionalities of blockchain technology that can change the traditional business processes of IT applications. These functionalities increase the data transparency, and trust of users in the new application models, thus resolving many different social problems today. In this work, we take all the advantages of this technology to build a blockchain-based authentication system (called the Vietnamese Educational Certification blockchain, which stands for VECefblock) to deal with the delimitation of fake certificate issues in Vietnam. In this direction, firstly, we categorize and analyze blockchain research and application trends to make out our contributions in this domain. Our motivating factor is to curb fake certificates in Vietnam by applying the suitability of blockchain technology to the problem domain. This study proposed some blockchain-based application development principles in order to build a step by step VECefblock with the following procedures: designing overall architecture along with business processes, data mapping structure and implementing the decentralized application that can meet the specific Vietnamese requirements. To test system functionalities, we used Hyperledger Fabric as a blockchain platform that is deployed on the Amazon EC2 cloud. Through performance evaluations, we proved the operability of VECefblock in the practical deployment environment. This experiment also shows the feasibility of our proposal, thus promoting the application of blockchain technology to deal with social problems in general as well as certificate management in Vietnam. | 2022-12-25T04:17:27.930Z |
27,561,129 | {
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"DOI": "10.1080/00015458.2004.11679638",
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} | Abstract Pedal artery bypass has proven to be a safe, simple and durable procedure. Failure of a pedal artery reconstruction seldom results in an amputation that is more proximal than it would have been without previous attempted bypass. Thus an aggressive strategy in the revascularisation of the forefoot in case if critical ischemia based on tibial occlusive disease is worthwhile. | 2022-09-15T16:34:31.212Z |
248,529,279 | {
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"DOI": "10.1515/ijcre-2022-0019",
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} | Abstract The traditional combined model of a mixed flow reactor and a plug flow reactor in series with a dead zone has been commonly used to characterize tundish flows in continuous casting of steel. However, there are noticeable differences in residence time distribution curve profile between model predictions and the corresponding experimental measurements. In order to pursue a better characterization of typical tundish flows, two new combined models are outlined in the current work: One involves uniform tanks and a plug flow reactor in series with a dead zone, while the other features two non-uniform tanks and a plug flow reactor in series with a dead zone. The application of the models to a tundish with a turbulence inhibitor in the pouring compartment reveals that both of the two new models can provide a much better representation of the experimental measurements in comparison with the traditional model. Regarding the two new models, the one with two non-uniform tanks is seen to perform better than that with uniform tanks. | 2022-10-31T13:20:39.295Z |
252,983,387 | {
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"DOI": "10.26788/riepg.v6i1.53",
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"url": "http://revistas.unap.edu.pe/epg/index.php/investigaciones/article/download/53/74"
} | RESUMENLas inversiones mineras y su impacto en la sociedad es un tema de análisis que ha sido abordado desde diferentes ópticas; el Perú es considerado como país minero y dentro de América Latina se ha constituido en uno de los mayores promotores de grandes inversiones como modelo de desarrollo. El estudio tiene como objetivo determinar el nivel de impacto de las inversiones en minería, en los indicadores macroeconómicos de la economía peruana; la relación con los conflictos socioambientales, y los índices de desarrollo humano, establecer el nivel de impacto del modelo de desarrollo. Para lograr este propósito se aplicó estadística y software especializado; evaluándose, de manera retrospectiva, información oficial del Ministerio de Energía y Minas, Defensoria de Pueblo, INEI y otras vinculadas, considerándose a todas las regiones del país. Los resultados encontrados muestran una asociación directa para todas las variables macroeconómicas de estudio, destacándose las exportaciones, los ingresos del país y las trasferencias a los gobiernos regionales y locales; por su parte las inversiones con los conflictos tienen una correlación positiva alta y una baja correlación para inversiones y las variables de índice de desarrollo humano; lo que permite concluir que la actividad minera en las regiones constituye el sector que aporta económicamente de manera significativa, aunque esto no se traduce en indicadores directos de desarrollo humano.Palabras clave: Conflictividad social, desarrollo sostenible, desarrollo económico, índice de desarrollo humano, inversiones mineras | 2022-11-25T00:28:44.289Z |
143,978,097 | {
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"DOI": "10.1590/S1414-98932002000400011",
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} | Este estudo descreve as representacoes sociais de profissionais da area de Recursos Humanos do Banco do Brasil sobre prazer e sofrimento no trabalho. A pesquisa tem fundamentacao teorica na Psicodinâmica do Trabalho e na Teoria das Representacoes Sociais. A metodologia adotada e de orientacao qualitativa, utilizando-se a tecnica do grupo focal como principal meio de coleta dos dados. Os participantes da pesquisa reconhecem a existencia de situacoes que geram prazer e sofrimento no Banco do Brasil e admitem que e papel dos profissionais de Recursos Humanos intervir nas situacoes de sofrimento, com o objetivo de diminui-lo e de potencializar as vivencias de prazer na Organizacao. | 2022-12-10T09:10:31.642Z |
344,324 | {
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"ArXiv": null,
"DOI": "10.1111/j.1572-0241.1998.00347.x",
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} | The cause of Ménétrier's disease is unknown, although various autoimmune, allergic, and infective causes have been postulated. This case report describes a 37-yr-old man with Ménétrier's disease associated with protein-losing enteropathy and Helicobacter pylori infection. Clinical, endoscopic, histological, and biochemical resolution occurred after treatment of Helicobacter pylori infection. The improvement observed in this case supports an etiological role for H. pylori infection in Ménétrier's disease. | 2022-12-10T12:07:23.609Z |
231,826,421 | {
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"DOI": "10.1109/ISOCC50952.2020.9333001",
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} | A scalable low power consumption high-voltage driver comprising only standard low-voltage CMOS transistors is proposed. The circuit is a Stacked MOSFET high-voltage driver. The proposed design stands out for its low power consumption (in the order of microwatts), small area, scalability and self-sufficiency. The main setbacks to be considered are its low switching speed, in the order of microseconds, and the fact that its applicability is limited to capacitive loads and high resistive loads. This paper reports simulation results obtained through the implementation of multiple designs in 0.18 um CMOS technology. | 2022-12-12T01:05:45.151Z |
234,028,047 | {
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"ArXiv": null,
"DOI": "10.1039/D1RA90036F",
"MAG": "3122084845",
"PubMedCentral": "8694640"
},
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} | Retraction of ‘PKM2 overexpression protects against 6-hydroxydopamine-induced cell injury in the PC12 cell model of Parkinson’s disease via regulation of the brahma-related gene 1/STAT3 pathway’ by Lei Jiang et al., RSC Adv., 2019, 9, 14834–14840, DOI: 10.1039/C9RA01760G. | 2022-12-16T21:32:47.252Z |
196,212,375 | {
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"DOI": "10.21107/JPGPAUD.V4I2.3571",
"MAG": "2949485381",
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} | This study aims to produce multimedia products to recognize the concept and symbol of PAUD numbers are feasible to use in the learning process. The feasibility of multimedia learning in terms of material aspects, learning, display and programming with validation of material experts and media experts. In the implementation phase of feasibility in terms of attractiveness, ease of use and clarity assessed by the child. This research method is research and development method of R & D with ADDIE learning design model that is (1) Analysis (2) Design (3) Development (4) Implementation (5) Evaluation. The result of the feasibility of multimedia data obtained from the average validation of material experts is 0.90 with the category "very high" and the average media expert validation is 0.94 with the category "very high". The result of implementation in PAUD Mutiara Kasih Kebumen viewed from the aspect of attractiveness, easiness and clarity of multimedia product with the average field test result of each aspect is 93,3% with "very high" category. Based on the results of validation of material experts and media experts and field trials concluded that multimedia learning products using adobe flash CS6 program is feasible to be used in the learning process to know the concept and symbol of the numbers for early childhood. | 2022-12-17T16:56:38.134Z |
128,598,677 | {
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"DOI": "10.6165/TAI.2000.45(1).107",
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} | This study focused on a remnant of lowland rain forest in the Nanjenshan Reserve of southern Taiwan. During 1989-1994, two long-term plots of 2.1 and 3 ha were set up at Lanjenchi (hill) and Nanjenshan (valley) sites, and forest composition, structure and species diversity were compared between the two plots. In the Lanjenchi plot, the most important families (sum of basal areas of all species within that family) were Fagaceae, Theaceae, Aquifoliaceae, Illiciaceae, Lauraceae and Myrtaceae, while in the Nanjenshan plot, the most important families were Euphorbiaceae, following by Moraceae, Meliaceae, Lauraceae, Aquifoilaceae, Urticaceae and Lythraceae, which bore some similarities to the tropical rain forests both in physiognomy and structure. Both TWINSPAN classification and DCA ordination separated the windward forest from the leeward forest stands in the Lanjenchi plot, but no such pattern could be recognized for the Nanjenshan plot. In the Lanjenchi plot, both species composition and forest structure changed dramatically with exposure due to chronic monsoon wind-stress. As wind stress increased, canopy height decreased from 15-20 m in the creek bottom to 3-5 m in the most exposed windward habitat. Stem density increased steadily with increasing exposure, and mean similarity among quadrats become higher as well. Total basal areas were comparable between the plots and forest stands. Dominance-diversity curve for each of the forests conformed to a lognormal distribution. There was a strong tendency for species diversity to be higher in the less exposed forests. | 2022-12-26T21:39:22.198Z |
133,796,152 | {
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"DOI": "10.5445/KSP/1000003344",
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} | Windschutzstreifen werden seit langem angelegt, um insbesondere landwirtschaftlich genutzte Flachen vor Windangriffen zu schutzen. Aufgrund eines steigenden Umweltbewusstseins und infolge von erhohten Anforderungen im Emissionsschutz gewinnen Windschutzanlagen heutzutage vor allem an der stadtisch-industriellen Schnittstelle zunehmend an Bedeutung.
Als Windschutzanlagen kommen dabei oftmals einzelne linienformige, ebenerdige (wallose) oder wallbehaftete Geholzstreifen zum Einsatz, deren Wirksamkeit als hinreichend erforscht angesehen werden kann.
Daruber hinaus werden jedoch immer haufiger ganze Industrieflachen von einer Windschutzanlage umgeben. Dies geschieht bevorzugt z. B. bei Deponien und Umschlagplatzen von Schuttgutern oder bei Produktionsstatten, bei denen unter Umstanden sogar schwermetallhaltige Schwebstoffe erzeugt werden. Derartige Windschutzanlagen sind vor allem in dichtbesiedelten Gebieten anzutreffen.
Industrieflachen werden windberuhigt, indem durch geeignete Windschutzanlagen eine Reduktion konvektiver Stromungsgrosen im Schutzgebiet erzielt wird. Dadurch werden gleichzeitig angrenzende Siedlungsgebiete vor starken Immissionen geschutzt.
Im Gegensatz zu einzelnen linienformigen Windschutzstreifen war der Wissensstand uber die Stromungszustande bei einer Doppelanordnung, d.h. bei Anordnung je eines Streifens luv- und leeseits einer windzuberuhigenden Flache, zu Beginn dieser Studie sehr luckenhaft. Durch systematische Windkanaluntersuchungen sollten daher grundlegende Beziehungen zwischen den relevanten Einflussparametern einer Windschutzanlage (Porositat der Bewuchsstreifen, Boschungswinkel, Verhaltnis Bewuchshohe zu Sockelwallhohe und Abstand der begrenzenden Streifen) und deren Schutzwirksamkeit erfasst werden. Zu Validierungszwecken wurden auch numerische Berechnungen mit einem k-Epsilon Turbulenzmodell durchgefuhrt.
Die Ergebnisse zeigen, dass der Abstand der beiden Windschutzstreifen und die Porositat der Bewuchsstreifen einen grosen Einfluss auf die Windschutzwirkung der Anlage ausuben, wahrend der Einfluss der Sockelwallgeometrie gering ist. Ein variiertes Verhaltnis von Bewuchs- zu Sockelwallhohe wirkt sich bei undurchlassigen Windschutzstreifen konstanter Gesamthohe ebenfalls nur wenig aus. Die Schutzwirkung eines Walls ohne Bewuchs ist jedoch deutlich schlechter. Bei mitteldichten Bewuchsstreifen bewirkt ein variiertes Hohenverhaltnis vor allem im nahen Lee der Streifen starke Veranderungen. Mit den abgeleiteten Schutzvolumen, welche die Grose geschutzter Bereiche abhangig von der Art und vom Grad der Schutzwirkung beschreiben, wird dem planenden Ingenieur eine Bemessungsgrundlage fur solch doppelt angeordnete Windschutzanlagen geliefert. | 2022-03-07T23:13:15.697Z |
94,397,745 | {
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"DOI": "10.1039/C39790000792",
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} | The synthesis of 1-(nonafluoro-t-butyl)-3-trifluoromethylpyrazoles (3) from hexafluoroacetone azine (1) and alkoxyacetylenes is described; the reaction involves an azomethine imide intermediate which rearranges by apparent [1,4] migration of a trifluoromethyl group. | 2022-09-27T16:47:38.341Z |
101,606,103 | {
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"DOI": "10.6023/CJOC201301065",
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} | The oxidation of tertiary amines is an improtant process in nature. In chemistry, organic chemists have made great efforts to study on the simulation of enzymatic funtion of oxidation with transition metal catalyst. It provide us new and efficient protocols for the synthesis of nitrogen compounds. The catalytic reactions also enhances our understanding the mechanism of the oxidation of tertiary amins in living system. During this decade, significant progress has been made in the transition metal catalyzed oxidation of tertiary amines. This review is summarized by five types of oxidative transformation of tertiary amines: (1) synthesis of N-oxides of tertiary amines; (2) oxidative Mannich reaction of tertiary amines; (3) oxidative demethylation of tertiary amines; (4) oxidative amidation of tertiary amines; (5) oxidative transformation of the substituents of tertiary amines. | 2022-10-01T16:04:27.949Z |
22,929,119 | {
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"DOI": "10.1021/jp503285w",
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} | Processes involved between colliding droplets were investigated using simultaneous analysis of spectra and images of Raman-scattered light emitted by irradiation with a pulsed laser. This enabled spatially and temporally resolved Raman spectra of the colliding droplets to be obtained. Colliding droplets of ethanol and water produce a characteristic protrusion from the contact point to the antipode of the water droplet in the course of interaction. From its Raman spectrum, the protrusion is seen to be composed of water. This result supports our surface-tension release model previously proposed to describe the mechanism of protrusion formation because the protrusion is the result of positive interference of a capillary wave propagating over the surface of the water droplet in this model. | 2022-12-09T10:34:48.659Z |
56,040,931 | {
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"DOI": "10.1590/S0001-37652011000400009",
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} | The limits between sea and land were estimated at "Pulso" beach located in the Southeastern Brazilian shelf (φ = 23°33/17.4886"S; Λ = 045° 13'13.0504"W - WGS84), between the island of Sao Sebastiao and the city of Ubatuba, SP, Brazil. The relative sea level of the year 1831 at "Pulso" beach, as per Brazilian law Number 9760 dated from 1946, was estimated and materialized. The retro-estimation allowed the demarcation of the Legal Sea-Land Limits at "Pulso" beach as per the terms of the law. The accuracy of the procedure for the transference of the long-term sea level from the research station of Ubatuba to "Pulso" beach was assessed by parallel work of geometrical leveling referred to the IBGE (Brazilian Institute of Geography and Statistics) geodetic network. The motivation, the hypotheses (Brest, Cananeia and IPCC) and the methods here used are described, together with a short history of the Legal Sea-Land Limits. The results indicated that the legal Sea-Land Limits at "Pulso" beach are well within the beach area. They were determined as per law 9760, and there is the need to reactivate the national network of sea level gauge. | 2022-12-10T09:07:50.375Z |
234,211,612 | {
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"DOI": "10.30734/JPE.V8I1.1501",
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} | Entrepreneurial women are those who run a business innovatively, they are also very confident, creative and able to achieve economic independence both individually and collectively with others and increase their active role in economic activities. Entrepreneurship that exists within individuals arises from objective realities that exist in society, which will continue to develop and interact and acculturate so that it will create a new identity for the person concerned so that this raises questions and needs to be studied more deeply about the process of significance in the process. the lessons that women entrepreneurs take towards their business success. This research was conducted in an effort to comprehensively reveal the existence of women entrepreneurs in their activities by using a qualitative approach in order to obtain deeper results. The way in which women entrepreneurs experience the learning process is found in terms of internal locus of control. Learning is important in entrepreneurship, because entrepreneurship reflects the complex interactions between individuals and business situations that are always changing. | 2022-08-20T10:08:03.749Z |
24,109,858 | {
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"DOI": "10.1080/02640414.2012.671532",
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} | Abstract The aim of this study was to quantify joint compression and shear forces at L4/L5 during exercises used to overload the hips. Nine men performed 36 “walking” trials using two modalities: (1) sled towing and (2) exercise bands placed around the ankles. Participants completed forward, backward, and lateral trials with bent and straight legs at three separate loads. Surface electromyography (EMG) was recorded bilaterally from eight torso and thigh sites, upper body and lumbar spine motion were quantified, and hand forces were measured. An EMG-driven musculoskeletal model was used to estimate the muscular contribution to joint compression and shear. Peak reaction, muscle and joint compression and shear forces, and peak gluteus medius and maximus activity were calculated. Significant differences were noted in each dependent measure; however, they were dependent on direction of travel, leg position, and load. The highest joint compression and shear forces for the sled and band conditions were 4378 N and 626 N, and 3306 N and 713 N, respectively. In general, increasing the band tension had little effect on all dependent measures, although a load-response was found during the sled conditions. Before using any exercise to improve hip function, the potential benefits should be weighed against “costs” to neighbouring joints. | 2022-09-02T09:14:44.282Z |
8,935,060 | {
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"DOI": "10.1063/1.4802433",
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"url": "http://liu.diva-portal.org/smash/get/diva2:618950/FULLTEXT01"
} | Arc plasma from Ti-Si compound cathodes with up to 25 at. % Si was characterized in a DC arc system with respect to chemistry and charge-state-resolved ion energy. The plasma ion composition showed a lower Si content, diverging up to 12 at. % compared to the cathode composition, yet concurrently deposited films were in accordance with the cathode stoichiometry. Significant contribution to film growth from neutrals is inferred besides ions, since the contribution from macroparticles, estimated by scanning electron microscopy, cannot alone account for the compositional difference between cathode, plasma, and film. The average ion charge states for Ti and Si were higher than reference data for elemental cathodes. This result is likely related to TiSix phases of higher cohesive energies in the compound cathodes and higher effective electron temperature in plasma formation. The ion energy distributions extended up to ∼200 and ∼130 eV for Ti and Si, respectively, with corresponding average energies of ∼60 and ∼... | 2022-09-22T21:09:32.974Z |
30,404,091 | {
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"DOI": "10.2519/jospt.2008.2726",
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} | STUDY DESIGN
Preinstruction and postinstruction testing in a laboratory setting.
OBJECTIVES
To examine the predictive relationship between lower extremity muscle strength and the immediate postinstruction changes in landing patterns of female athletes. We hypothesized that greater strength would be associated with larger postinstruction improvements in landing patterns.
BACKGROUND
Female athletes in high-demand sports may be predisposed to anterior cruciate ligament injury because of poor landing patterns. Instruction has been shown to improve landing patterns. Lower extremity muscular strength may determine the potential for instruction to alter landing patterns.
METHODS AND MEASURES
Thirty-seven female collegiate athletes in high-demand sports participated. Strength was assessed in the following muscle groups: trunk extensors and flexors, hip abductors and extensors, knee flexors and extensors, and ankle plantar flexors. Strength testing was followed by kinetic and kinematic analysis of a drop vertical jump task. Athletes then received verbal instruction on how to improve their landing technique and were retested. Landing variables of interest were force absorption time, peak vertical ground reaction force (vGRF), peak knee flexion and abduction angle, and peak external knee abduction moment. Preinstruction and postinstruction landing variables data were compared. Linear regression models were created with strength values as independent variables and landing variables as dependent variables.
RESULTS
After instruction, athletes significantly increased their force absorption time and peak knee flexion angle, while decreasing their peak vGRF, peak knee abduction angle, and peak external knee abduction moment (P<.001). None of the regression models were statistically significant (P>.05).
CONCLUSIONS
A brief instructional session promotes short-term improvements in the landing patterns of collegiate female athletes, but muscular strength was a poor predictor of the improvements. | 2022-12-10T09:38:09.452Z |
8,523,974 | {
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"DOI": "10.1002/cncr.27473",
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} | For this article, the authors examined the cost implications of the prospective surveillance model (PSM) for breast cancer (BC) survivors, a comprehensive framework designed to preemptively reduce the incidence and virulence of common impairments. The model clearly has the potential of providing significant benefits. However, its accompanying costs and resource requirements remain unclear and may be substantial. Thus, it is critical to examine which BC survivors may benefit from the PSM, how much they will benefit, and the costs of this benefit before its implementation. Because the PSM is not rigidly prescriptive, its examination must allow for different scenarios with emphasis on 4 critical determinants of cost—whether all or only high‐risk BC survivors participate, assessment frequencies and locations, the credentials of the assessors, and requirements for supportive equipment. Another issue is the distribution of its cost: hypothetical implementation strategies vary widely in their distribution of fiscal burden across key stakeholders—survivors, providers, and payers—whose financial responsibilities will be an important factor in whether and how rapidly they adopt the PSM. Accurate valuation of the PSM will require capture of direct and indirect cost savings and benefits. Currently, a lack of data regarding these parameters, as well as outcomes that can be reliably attributed to the PSM, impedes cost‐effectiveness analyses. Because the PSM may enhance many health state characteristics, assessments that integrate overall composite measures with evaluations of common, discrete impairments may be required to comprehensively assess its benefits. Cancer 2012;118(8 suppl):. © 2012 American Cancer Society. | 2022-12-21T03:02:39.729Z |
25,340,501 | {
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"DOI": "10.3892/mmr.2016.5030",
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"url": "https://www.spandidos-publications.com/10.3892/mmr.2016.5030/download"
} | Oxidative stress has been demonstrated to be important during myocardial ischemia/reperfusion injury (MIRI). The lazaroid U83836E, which combines the amino functionalities of the 21‑aminosteroids with the antioxidant ring portion of vitamin E, is a reactive oxygen species scavenger. The aim of the current study was to investigate the effect of U83836E on MIRI and its mechanisms of action. Rat hearts were subjected to 30 min ligation of the left anterior descending coronary artery, followed by 2 h reperfusion. The results demonstrated that at 5 mg/kg, U83836E markedly protected cardiac function in ischemia/reperfusion rat models, decreased the malondialdehyde content and creatinine kinase activity, while increasing superoxide dismutase and glutathione peroxidase activity. Additionally, U83836E significantly decreased the histological damage to the myocardium, reduced the area of myocardial infarction in the left ventricle and modified the mitochondrial dysfunction. Furthermore, U83836E enhanced the translocation of protein kinase Cε (PKCε) from the cytoplasm to the membrane. However, the cardioprotective effects of U83836E were reduced in the presence of the PKC inhibitor, chelerythrine (1 mg/kg). Therefore, the results of the present study suggest that U83836E has a potent protective effect against MIRI in rat models through the direct anti‑oxidative stress mechanisms and the activation of PKC signaling. | 2022-12-25T04:20:31.045Z |
212,712,878 | {
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} | Introduction. Camptocormia is an extreme flexion of the toracolumbar spine that exacerbates by walking and is relieved in the supine position. It is described with increasing frequency in association with Parkinson disease (PD). Its pathogenesis remains unclear. One of the hypotheses proposed defends that when associated with PD probably it is a focal action dystonia of the paraspinal muscles. Dystonia may be accompanied of a “geste antagoniste”. It is a kind of trick that enables the patient to alleviate dystonic posture. We present two cases in which the patients use sensory tricks to alleviate their posture during gait. Case Reports. Patient 1: A 74-year–old woman, with a 2-year of PD. Clinical examination disclosed parkinsonian signs and camptocormia. She was able to partially overcome it by pushing her hands against her thighs. Patient 2: A 80-year-old woman, with a 1-year probable PD. Neurological examination revealed postural instability, freezing gait and camptocormia that partially remits when she pushes a bar at the level of her waist. Conclusions. The particularity of these cases is that patients are able to improve camptocormia during gait by specific tricks. This clinical improvement supports the hypothesis that camptocormia in PD is a focal dystonia of the paraspinal muscles. | 2022-02-08T02:52:46.234Z |
72,081,924 | {
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} | Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC
The Cancer Genome Atlas Project (TCGA) has produced a wide array of omic data on glioblastoma multiforme (GBM) tumors, and has resulted in several works on the molecular subtyping of GBM tumors. Despite its richness, the TCGA dataset currently contains very limited data for low-grade gliomas and progressive GBMs, preventing analysis of progression models and prognostic biomarker discovery for these tumor types. A complementary dataset, the NCI Repository for Molecular Brain Neoplasia Data (REMBRANDT), includes a collection of samples for low-grade and progressive gliomas. This data contains some paired tumors that progressed to GBM and like TCGA, includes pathological and survival information. Our in silico study of low-grade and progressive gliomas has leveraged this complementary data to examine the progression of low-grade gliomas to GBM. The REMBRANDT dataset includes 176 samples with survival outcome data, including 101 grade IV GBM, 32 astrocytomas, and 43 oligodendrogliomas. Of the astrocytomas and oligodendrogliomas, there are 31 grade II samples and 31 grade III samples, with the remainder lacking grade data. We have investigated the gene expression profiles of the REMBRANDT samples to compare them to the established classes from TCGA and other studies. Candidate prognostic biomarkers have been identified to predict the progression of low-grade gliomas. We have found that the TCGA Proneural subtype predicts improved clinical outcome for low-grade oligodendrogliomas, with significantly better survival among all 176 low and high-grade samples (log rank test p = 1.27e-08). Moreover, analysis of 62 grade II and grade III samples determined that the Proneural class still has significantly better outcome (p= 0.0033). Further sub-analysis to control for oligodendrogliomas and grade, found that grade III oligodendrogliomas with the Proneural signature still had significantly improved survival (p < 0.05, n = 12). Stratification using the signatures developed by Li et al that define six oligodendrioma and glioma subtypes demonstrated that the OA subclass had significantly better survival (log rank test p = 9.14e-08). However, these signatures were not significant in multivariate analysis after controlling for grade and disease subtype. Thus, the gene expression patterns identified in the TCGA analysis of GMB has intrinsic prognostic value for low-grade oligondendriomas, and likely represents important differences in tumor biology with implications for treatment and therapy.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 113. | 2022-02-11T10:15:03.189Z |
98,202,230 | {
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} | Internodal growth of bamboo was characterized by analyzing chemical composition, X-ray diffraction and CP/MAS solid state 13 C-NMR. When the longest (17th) internode of an 6m-high immature moso-bamboo (Phyllostachys pubescens Mazel), 29.8 cm in length, was sliced into 28 rings and subjected to the analyses, growth of bamboo was concluded to occur upward from the secondary meristem localized at 1.06-2.13 cm above the node. CP/MAS solid state 13 C-NMR proved to be useful in a rapid determination of the exact position of the secondary meristem. | 2022-02-10T12:54:35.962Z |
145,294,989 | {
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} | The dramatic changes in the political, economic, cultural and religious panorama in Eastern Europe between 1989 and 1991 demanded new responses from both churches and ecumenical bodies. Also in Estonia the churches were suddenly faced with changes in legislation on religious denominations and church-state relations were entailed to provide for the restitution of church property. Other questions at stake were: how do churches understand themselves in the new circumstances? How are their relations to one another? And what is their role in the new society? In addition the churches in Estonia also had to struggle with the answers in a profound secular context. As a country in the former communist Eastern Europe Estonia tells its own newsworthy story. This article highlights the ecumenical relations and developments since 1991 in Estonia. | 2022-02-09T06:35:05.298Z |
54,923,965 | {
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"DOI": "10.22436/jmcs.016.03.14",
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"url": "https://www.isr-publications.com/jmcs/1326/download-on-the-solution-of-linear-and-nonlinear-partial-differential-equations-applications-of-local-fractional-sumudu-variational-method"
} | In this paper, the local fractional Sumudu variational iteration method is being used to investigate the solutions of partial differential equations containing the local fractional derivatives. The present technique is the combination of the local fractional Sumudu transform and fractional variational iteration method. Three illustrative examples are given to demonstrate the efficiency of the method. c ©2016 all rights reserved. | 2022-02-11T20:25:56.627Z |
168,147,771 | {
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"DOI": "10.1002/NVSM.1546",
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} | In this paper, we examine the characteristics of charities that have generated substantive increases in their fundraising income. We interviewed 25 fundraising directors and team members, from organizations experiencing rapid growth, adopting a “decoding the discipline” approach to identify how each organization had overcome key barriers to its success. We identify that fundraising leaders in these exceptional nonprofits focus particularly on matters connected to their team, organizational structures that support that team, and the development of an organization-wide learning culture. We also find that these teams were successful because of the “systems” way in which they understood and coped with the complexities of decision making. They were exceptional in isolating the right problems and exceptional too in the processes they adopted to solve them.
Copyright © 2016 John Wiley & Sons, Ltd. | 2022-09-14T18:09:31.230Z |
1,295,907 | {
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"DOI": "10.1209/EPL/I1999-00305-X",
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} | The flow of granular matter such as sand is often characterized by the motion of a thin superficial layer near the free surface, while the bulk of the solid remains immobile. A pair of equations called the BCRE equations (Bouchaud J-P., Cates M. E., Ravi Prakash J. and Edwards S. F. J. Phys. 4 (1994) 1383) have been proposed to model these flows and account for the dynamic exchange of mass between moving and stationary grains using the simplest kinematic considerations. We uncover a new conservation law for the BCRE equations and its variants that unifies a variety of recent special solutions and show that these equations support simple waves, and are capable of finite time singularities that correspond to propagating erosion fronts. | 2022-09-16T08:37:21.006Z |
96,726,134 | {
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"DOI": "10.1051/ATA:2007026",
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} | La fibrose systemique nephrogenique (FSN) est une pathologie rare, d'etiologie inconnue, observee chez des patients souffrant d'insuffisance renale severe. Cette pathologie systemique, dont la morbidite est elevee, affecte principalement la peau. Plusieurs publications recentes evoquent un lien de causalite entre l 'exposition aux produits de contraste a base de gadolinium utilises en imagerie medicale et le developpement de la FSN. Nous decrivons un cas de FSN, confirmee par une biopsie cutanee, chez une patiente de 62 ans en insuffisance renale et sous hemodialyse. De nombreuses injections de produits de contraste contenant des chelates de gadolinium ont ete pratiquees chez cette patiente. Ce cas de FSN est le premier associe a des dosages de gadolinium ( l57 Gd) dans le plasma et le sang total, mais egalement dans les cheveux et les ongles. Les concentrations et teneurs en l57 Gd, mesurees avec une technique utilisant une torche a plasma couplee a un spectrometre de masse (ICP-MS), sont tres elevees. Les resultats obtenus illustrent une nouvelle fois l'association probable entre l'exposition au gadolinium et la fibrose systemique nephrogenique chez des sujets en insuffisance renale terminale. Le dosage du gadolinium dans les milieux biologiques pourrait avoir un interet probant chez les patients insuffisants renaux ayant necessite un examen d'imagerie medicale avec injection de gadolinium. | 2022-11-11T08:02:26.912Z |
248,700,584 | {
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"DOI": "10.3389/fninf.2022.895290",
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"url": "https://www.frontiersin.org/articles/10.3389/fninf.2022.895290/pdf"
} | Accurate labeling is essential for supervised deep learning methods. However, it is almost impossible to accurately and manually annotate thousands of images, which results in many labeling errors for most datasets. We proposes a local label point correction (LLPC) method to improve annotation quality for edge detection and image segmentation tasks. Our algorithm contains three steps: gradient-guided point correction, point interpolation, and local point smoothing. We correct the labels of object contours by moving the annotated points to the pixel gradient peaks. This can improve the edge localization accuracy, but it also causes unsmooth contours due to the interference of image noise. Therefore, we design a point smoothing method based on local linear fitting to smooth the corrected edge. To verify the effectiveness of our LLPC, we construct a largest overlapping cervical cell edge detection dataset (CCEDD) with higher precision label corrected by our label correction method. Our LLPC only needs to set three parameters, but yields 30–40% average precision improvement on multiple networks. The qualitative and quantitative experimental results show that our LLPC can improve the quality of manual labels and the accuracy of overlapping cell edge detection. We hope that our study will give a strong boost to the development of the label correction for edge detection and image segmentation. We will release the dataset and code at: https://github.com/nachifur/LLPC. | 2022-12-14T09:14:04.469Z |
58,793,206 | {
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} | Providing medical care to the underprivileged is a mission of the Sisters of St. Joseph at St. Joseph Hospital in Orange, California. An outpatient family medical clinic was established to serve this population, a majority of whom do not have health insurance or access to government-sponsored prescription assistance programs. To provide medications to patients and to help reduce medication costs, the pharmacy department opened a medication room in the clinic and staffed it with a pharmacist and a pharmacy technician. This effort involved maximizing the use of pharmaceutical companies’ patient assistance programs, which provide free medications to qualified indigent patients. The project also incorporated pharmacist-regulated involvement; the development of and compliance with a formulary; strict inventory controls on the purchase of medications; and identification of patients who qualify for government health service programs. A computer database program that simplified the tracking, reporting, and organizing of patient information and provided financial reports was implemented. Within three years of operation, medication costs decreased from $328,000 to $32,800. The presence of a pharmacist in this setting was advantageous in both the financial and clinical arenas. The pharmacist was intimately involved in medication provision by evaluating appropriate medication use in a cost-effective manner and providing education to health care providers and patients. | 2022-09-12T03:27:38.019Z |
245,013,404 | {
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"DOI": "10.1182/hematology.2021000256",
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"url": "https://ashpublications.org/hematology/article-pdf/2021/1/247/1851712/247epperla.pdf"
} | The approval of brentuximab vedotin (BV) and checkpoint inhibitors (CPI) has revolutionized the management of relapsed/refractory classical Hodgkin lymphoma (cHL) patients. In recent years these agents have rapidly moved to earlier lines of therapy, including post-autologous hematopoietic cell transplant (auto-HCT) consolidation, pre-HCT salvage, and the frontline treatment setting. This shift in practice means that double-refractory (refractory to both BV and CPI) cHL is becoming an increasingly common clinical problem. In patients who are not eligible for clinical trials, conventional cytotoxic and targeted therapies (off label) may be a potential option. In patients who are transplant eligible, early referral to allogeneic HCT should be considered given the significant improvement in transplant outcomes in the contemporary era. Cellular therapy options including CD30.chimeric antigen receptor T cells, Epstein-Barr virus-directed cytotoxic T cells, and CD16A/30 bispecific natural killer cell engagers appear promising and are currently in clinical trials. | 2022-11-18T08:10:29.957Z |
86,714,365 | {
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"DOI": "10.4319/LO.1980.25.3.0549",
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} | A direct positive relationship was demonstrated between egg size and naupliar size in the calanoid copepod Diaptomus clavipes Schacht. Number of eggs per clutch and total clutch volume were inversely associated with measures of egg and naupliar size (egg volume, maximum egg length, naupliar volume, and maximum naupliar length). Thus, small clutches with large eggs give rise to large nauplii. | 2022-11-23T18:21:21.278Z |
121,489,417 | {
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"DOI": "10.1115/DSCC2014-6185",
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} | This paper considers the optimization of discrete-time control systems for power generation from stochastically-excited linear dynamical systems, characterized by infinite-dimensional dynamics. Weiner-Hopf theory is used to determine the physical upper bound on stationary power generation. The resultant expressions for power generation do not require a finite-dimensional state-space model to be specified at any point in the analysis. However, the constraint that the controller be causal leads to the need to perform spectral factorizations on two associated power spectra. In many cases, analytical solutions to these factorizations are intractable, and approximate numerical techniques must be used. This paper makes use of subspace identification techniques for approximate spectral factorization. The concepts are illustrated in a wave energy conversion example.Copyright © 2014 by ASME | 2022-12-03T20:32:58.322Z |
220,306,901 | {
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"DOI": "10.3390/biomedicines8070184",
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"url": "https://www.mdpi.com/2227-9059/8/7/184/pdf?version=1595381156"
} | Developmental genes are important regulators of fat distribution and adipose tissue (AT) function. In humans, the expression of homeobox c9 (HOXC9) is significantly higher in subcutaneous compared to omental AT and correlates with body fat mass. To gain more mechanistic insights into the role of Hoxc9 in AT, we generated Fabp4-Cre-mediated Hoxc9 knockout mice (ATHoxc9-/-). Male and female ATHoxc9-/- mice were studied together with littermate controls both under chow diet (CD) and high-fat diet (HFD) conditions. Under HFD, only male ATHoxc9-/- mice gained less body weight and exhibited improved glucose tolerance. In both male and female mice, body weight, as well as the parameters of glucose metabolism and AT function were not significantly different between ATHoxc9-/- and littermate control CD fed mice. We found that crossing Hoxc9 floxed mice with Fabp4-Cre mice did not produce a biologically relevant ablation of Hoxc9 in AT. However, we hypothesized that even subtle reductions of the generally low AT Hoxc9 expression may cause the leaner and metabolically healthier phenotype of male HFD-challenged ATHoxc9-/- mice. Different models of in vitro adipogenesis revealed that Hoxc9 expression precedes the expression of Fabp4, suggesting that ablation of Hoxc9 expression in AT needs to be achieved by targeting earlier stages of AT development. | 2022-12-02T11:20:45.143Z |
136,701,621 | {
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} | В Москве 8-10 ноября 2011 г. проходила Деcятая международная специализированная выставка «Криоген-Экспо». Её организатор — выставочная компания «Мир-Экспо». На выставке демонстрировали продукцию и технологии 75 компаний из 15-ти стран. Более половины компаний, участвующих в выставке, были отечественными. По сравнению с предыдущей выставкой на 20 % увеличилась её общая площадь. Выставку посетило 1000 специалистов, представлявших промышленные предприятия, научно-технические организации, исследовательские и учебные заведения. Была проведена Восьмая научно-практическая конференция «Криогенные технологии и оборудование. Перспективы развития» с семинаром «LNG Shipping». На ней российские и зарубежные специалисты сообщили о результатах научных исследований, разработке новых низкотемпературных технологий и видов оборудования. Экспозиции выставки отразили возросший уровень криогенного машиностроения, ознакомили посетителей с инновационными низкотемпературными технологиями. Хорошая организация выставки позволила создать для её участников условия, способствующие налаживанию деловых контактов и партнерских отношений. | 2022-02-09T11:00:19.412Z |
13,067,401 | {
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"DOI": "10.13107/jocr.2250-0685.211",
"MAG": "2487598355",
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} | Journal of Orthopaedic Case Reports | pISSN 2250-0685 | eISSN | Available on www.jocr.co.in | doi: 2321-3817 10.13107/jocr.2250-0685.211 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Social Media and Orthopaedic Surgeon: Concept of Orthopaedic Educational and Academic Network (OCEAN) | 2022-02-13T03:54:23.026Z |
235,587,429 | {
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} | This article aims at discussing the access of deaf individuals to higher education, specifically to the Technology and Tourism Management Course at the Goiás State University, Cora Coralina Campus., based on Law 10,436/02 which guarantees Libras is used as the deaf community official language and the Decree 5,626/05 which regulates the implementation of Libras as a discipline in higher education and as a compulsory instruction language in teaching contexts. Thus, our proposal seeks to demonstrate socialization and acceptance regarding deaf students, assessing how they feel, and their expectations throughout the inclusion process. We carry out this analysis resorting to reflections such as Santos (2016), Costa (2014) and Bisol, Valentini, Simioni e Zanchin (2010). By taking into account such a theoretical survey, we will discuss how deaf individuals are being integrated in higher education. | 2022-05-10T00:28:58.519Z |
9,236,305 | {
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"DOI": "10.15585/mmwr.mm6640a9",
"MAG": null,
"PubMedCentral": "5657936"
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"status": "BRONZE",
"url": "https://www.cdc.gov/mmwr/volumes/66/wr/pdfs/mm6640a9.pdf"
} | During 2012-2015, patients aged ≥65 years with hypertension documented in the medical record accounted for 54% of all office-based physician visits made by patients aged ≥65 years, with a higher percentage of visits in non-MSAs (59%) than MSAs (53%). Among women, the percentage of visits was also higher in non-MSAs than in MSAs (59% versus 53%). The difference among men was not statistically significant. | 2022-06-18T09:35:05.760Z |
40,360,077 | {
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"DOI": "10.1109/LEOS.2005.1548225",
"MAG": "2008384682",
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} | The paper describes the operation and application of thin disk lasers, an innovative laser concept that allows to build diode pumped solid state lasers with highest output power, efficiency and beam quality | 2022-08-25T02:30:49.739Z |
108,577,607 | {
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"DOI": "10.1115/IMECE2004-60516",
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} | Stage pressure ratios in screw compressors, operating without oil injection, are limited by deformation of the rotors, caused by the temperature rise of the compressed gas. Rotor cooling would reduce this restriction. As a result of identification of the main modes of heat transfer both in the rotors and between the rotors and their surroundings and the relative significance of each, a novel procedure is suggested to cool the rotors by injection of minute quantities of a volatile fluid. By this means the compressed gas should attain higher temperatures without rotor distortion. To confirm these concepts and quantify both the heat transfer rates and the rate of liquid injection required for rotor cooling, both a one dimensional flow study and a more complex 3-D numerical analysis were performed, the latter with the aid of a CFD code. The results indicated that the rotors could be maintained at a far lower temperature than that of the discharged gas by flash evaporative cooling, as a result of injecting a fractional percentage by mass of a volatile fluid. This was confirmed by experiment. This technique may be used to operate dry compressors at substantially higher pressure ratios than are currently possible in such machines. It is also shown that only minor design changes are needed to implement it.© 2004 ASME | 2022-09-10T12:48:16.381Z |
45,205,026 | {
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"DOI": "10.1109/ISCAS.2005.1465138",
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} | Current CMOS technology is reaching its scaling limits and thus the CMOS based devices are slowly being replaced by new nanotechnology devices. These nanotechnology devices, however, pose some simulation challenges due to their non-monotonic I-V characteristics and uncertain properties which lead to the negative differential resistance (NDR) problem and the chaotic performance of the simulator. This paper proposes a new circuit simulation approach that can effectively simulate nanotechnology devices, avoiding such problems. The experimental results show a 20-30 times speedup comparing with existing simulators. | 2022-09-11T22:01:24.102Z |
225,128,713 | {
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"DOI": "10.5958/0974-360x.2020.00817.3",
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} | The new realities, such as increased regulatory requirements, introduction of new gene and cellular therapies, and expectations of such therapies to be more affordable in healthcare facilities, require building a cold chain, which is very flexible and more reliable. Finding the most suitable provider of logistics services is an important part of building a cold chain for the pharmaceutical products supply. Selecting a logistics service provider is a decision-making process based on a few criteria and associated with the optimization of conflicting goals, such as quality, cost, and delivery time. A system to support decision on selecting a logistics service provider is suggested in this article, based on the method of analytical hierarchy process (AHP), which is widely used to solve multicriteria tasks. A case study is conducted by the example of a pharmaceutical industry manufacturer in order to validate the choice of the AHP model and to justify the conceptual design of the system to support decision on selecting a logistics service provider. | 2022-09-30T13:24:36.578Z |
172,086,503 | {
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"DOI": "10.7213/1980-5934.30.050.AO07",
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} | Se trata de presentar aquí la fundamentación ontológica de la ética de Patočka gracias a la cual se puede pensar la posibilidad de un cosmopolitismo. Por ello, planteamos el problema del cosmopolitismo, que nos remite al problema del aparecer de la ética en un mundo dominado por la técnica. Esta preocupación por la fenomenalización de la ética conduce a una tematización del sacrificio que nos hace enfrentar una aporía. Sin embargo, mostramos que la concepción asubjetiva de la fenomenología de Patočka permite solucionarla. | 2022-10-07T15:36:36.513Z |
31,052,871 | {
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} | In this paper we design high performance multiple-input-multiple-output (MIMO) receivers for the DFT-Spread-OFDM based long term evolution (LTE) cellular uplink. In the LTE uplink multiple single-antenna users can be scheduled on the same time-frequency resource block via space division multiple access. The designed receivers are also applicable to the LTE-Advanced cellular uplink wherein simultaneous transmission of multiple streams by a single user will be possible. Two types of advanced non-linear receivers are considered and optimized, namely, a receiver based on a two-symbol max-log soft-output demodulator (two-symbol MLD) and a turbo minimum mean squared error successive interference cancelation (turbo MMSE-SIC) receiver. Based on extensive simulations, it is shown that both the two-symbol MLD and the turbo MMSE-SIC receivers exhibit superior performance compared to the conventional linear MMSE (LMMSE) receiver. In general, the turbo MMSE-SIC receiver is robust to timing offsets and offers the best performance but also introduces larger latency and higher computational complexity. Upon employing a proposed new pairing method, the two-symbol MLD based receiver is also found to yield a good performance that is robust to timing offsets and which entails a moderate complexity and latency. | 2022-12-05T16:17:44.680Z |
134,565,572 | {
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"DOI": "10.22449/0233-7584-2017-4-48-60",
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"url": "http://xn--c1agq7a.xn--p1ai/images/files/2017/04/201704_05.pdf"
} | Content and composition of hydrocarbons (mainly the aliphatic ones) in the suspended matter and the bottom sediments in the Gelendzhik Bay, the Big Sochi water area, the Feodosiya Bay and the Black Sea central part are defined and compared with the total organic carbon and chlorophyll a contents. It is shown that the aliphatic hydrocarbon concentrations exceeding the background ones are found only in the coastal zone. Advancing to the pelagic zone is accompanied by sharp decrease of their concentrations. Petroleum and pyrogenic hydrocarbons are mainly manifested in the polycyclic aromatic hydrocarbons composition. Influence of construction of the Olympic facilities upon distribution of hydrocarbons in the Big Sochi water area was of short duration, and already by 2015 the aliphatic hydrocarbons concentration decreased, on the average, up to 24 μg/l in the surface waters, and up to 18 μg/g – in the bottom sediments. Accumulation of hydrocarbons took place in bottom sediments, where their concentrations exceeded the background ones in terms of dry weight. In the Gelendzhik Bay, their content reached 252 μg/g, and in the composition of organic carbon (Corg) > 1 %, which may indicate the contamination of sediments with oil products. In the Feodosiya Bay their part in the composition of Corg did not exceed 0.73 % and was 0.35 % on average. Natural alkanes dominated in the composition of aliphatic hydrocarbons. The bottom sediments are characterized by the predominance of odd high-molecular terrigenous alkanes. The content of polycyclic aromatic hydrocarbons in the studied sediments was rather low: up to 31 ng/g in the Gelendzhik Bay, up to 348 ng/g in the Feodosiya Bay. These concentrations according to the EPA classification are considered background, or minor petroleum hydrocarbons increase the level of aliphatic hydrocarbons in water and sediments, thus creating a modern hydrocarbon background. | 2022-12-20T23:33:06.886Z |
140,645,986 | {
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"DOI": "10.17139/RAAB.1999.002.1.%G",
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} | RESUMEN: Al igual que otras localidades punenas, Santa Rosa de los Pastos Grandes (Departamento Los Andes, provincia de Salta, Argentina) es una poblacion pequena (114 habitantes) y se encuentra parcialmente aislada, por lo que es de interes la evaluacion de sus niveles de endogamia asociados a la microdiferenciacion. Se extrajeron muestras de sangre y se determinaron los grupos sanguineos: ABO, MN, Ss, Cc, Dd, Ee, P, Diego y Kell-Cellano. Se calcularon las frecuencias genicas, genotipicas y haplotipicas, poniendose a prueba la hipotesis del equilibrio. Se obtuvieron medidas de variabilidad y se estimo el Indice de Fijacion (F) para los sistemas MN, Ss, Cc y Ee a fin de detectar efectos de endogamia. Tres sistemas (Dd, Diego y Kell-Cellano) resultaron monomorficos para los alelos D, Di*b y k. El locus ABO presenta los alelos I*O (0,982) y I*B (0,018). Segun datos de familia, los fenotipos I*B son heterozigotos por flujo genico. Tres loci (MN, Ss y Ee) no se encuentran en equilibrio, y presentan deficiencia de heterozigotos. Estos loci presentan Indices de Fijacion (F) positivos y significativamente diferentes de cero, debido a los efectos de endogamia. Es destacable la ausencia de Di*a del Sistema Diego ya que es considerado marcador de poblaciones americanas. Santa Rosa presenta variabilidad genetica reducida: Heterozigosis Media (H) = 0,136. Tres loci monomorficos, la falta de equilibrio en algunos sistemas, y los valores de H y de F, demuestran los efectos de la deriva. Rev. Arg. Antrop. Biol. 2(1): 227-242, 1999. ABSTRACT: Santa Rosa de los Pastos Grandes (Los Andes Department, Province of Salta, Argentina), as well as other localities in the Puna region, constitutes a small population (114 inhabitants). As a semi-isolated population, its endogamy indices are interesting from a micro-differentiation point of view. Blood samples were studied for the following group frequencies: ABO, MN, Ss, Cc, Dd, Ee, P, Diego and Kell-Cellano. The gene, genotypic and haplotypic frequencies were calculated, the equilibrium hypothesis being tested. Variability was measured and fixation index (F) was obtained for MN, Ss, Cc, and Ee systems in order to estimate endogamy effects. Three systems (Dd, Diego and Kell-Cellano) were monomorphic for D, Di*b and k alleles. ABO Locus showed I*O (0,982) and I*B (0,018) alleles. According to family information, I*B phenotypes were heterozygous due to gene flow. MN, Ss and Ee Loci were not in equilibrium, showing an heterozygous deficiency. These loci also presented fixation indices significantly different from zero due to the effects of endogamy. The absence of Di*a is remarkable, considering that it is a marker of American populations. Santa Rosa exhibits a reduced genetic variability (H = 0,136). The results point to the action of genetic drift in this population. Rev. Arg. Antrop. Biol. 2(1): 227-242, 1999. | 2022-02-09T08:57:24.273Z |
250,666,592 | {
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} | The International Conference on Theoretical Physics `Dubna-Nano2008' was held on 7–11 July 2008 at the Bogoliubov Laboratory of Theoretical Physics, Joint Institute for Nuclear Research, Dubna, Moscow region, Russia. The conference provided the opportunity for the presentation and discussion of theoretical and experimental advances in the rapidly growing area of the nanophysics, with the accent on its theoretical aspects. The multidisciplinary character of the conference allowed an effective exchange of ideas between different areas of nanophysics. The following topics were covered: carbon nanosystems (fullerenes, nanotubes, graphene), quantum dots, electron and spin transport, spectroscopy and dynamics of atomic clusters, Josephson junctions, bio-complexes, and applications of nanosystems. Approximately 90 scientists from 16 countries participated in the conference. The program included 48 oral talks and 40 posters. The 51 contributions are included in this proceedings. We would like to express our gratitude to all participants for their presentations and discussions, which made the conference so successful. We are deeply indebted to the members of the International Advisory Committee (Professors T Ando, S Datta, A V Eletskii, J Fabian, F Guinea, P Hawrylak, K Kadowaki, T Koyama, Yu I Latushev, N F Pedersen, P-G Reinhard, J M Rost, A Ya Vul') and the Local Organizing Committee for their fruitful work. The financial support of BLTP JINR, Russian Foundation for Basic Research, Heisenberg-Landau Program and Bogoliubov-Infeld Program was of a great importance. Additional information about `Dubna-Nano2008' is available at the homepage http://theor.jinr.ru/~nano08. Vladimir Osipov, Valentin Nesterenko and Yury Shukrinov Editors | 2022-07-22T12:52:04.359Z |
212,913,383 | {
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} | A partir d’une etude cyber-ethnographique d’une communaute virtuelle de maitres supplementaires travaillant a l’ecole primaire constituee sur les reseaux sociaux, nous avons cherche a identifier et comprendre les usages de cet outil technologique favorisant la communication a distance et asynchrone. L’analyse des discussions entre maitres supplementaires sur le groupe virtuel a permis de saisir au moins trois usages. Premierement, le groupe Facebook constitue un espace de socialisation professionnelle entre pairs, afin de s’acculturer a une culture commune de maitre supplementaire. Deuxiemement, les membres semblent utiliser ce groupe comme un espace d’echanges et de circulation de savoirs, favorisant leur interessement et leur enrolement au sein du dispositif « Plus de maitres que de classes ». Enfin, l’analyse des discussions permet d’identifier ce groupe comme un espace de soutien social et emotionnel, par l’intermediaire duquel certains maitres supplementaires en profitent pour partager des difficultes professionnelles liees a l’exercice de leur fonction. | 2022-08-25T01:41:38.689Z |
46,249,970 | {
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"DOI": "10.1090/dimacs/055/04",
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} | A cooking oven having at least the bottom wall and the two sides, and the rear wall, formed of embossed metal with a layer of vitreous porcelain enamel of dark porous matte finish covering the exposed surface of the embossed metal to have the continuous cleaning property during normal cooking operations of diminishing the accumulation of carbonaceous residue which results from the exposure to grease spatters during cooking. | 2022-09-02T15:08:20.041Z |
55,590,088 | {
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} | Embora alguns trabalhos pioneiros sobre a neotectonica no Brasil tenham vindo a lume ha mais de 40anos, o real interesse por este assunto foi despertado somente na decada de 70 devido a construcao denumerosas e gigantescas obras de engenharia civil, tais como as usinas hidreletricas e termonucleares.O papel mais relevante da neotectonica na evolucao do litoral brasileiro pode ser demonstrado, demaneira inquestionavel, pelas bacias marginais, que sao uma evidencia de macro-escala (ou escalacontinental). Essas bacias foram mais ativas do Cretaceo ao Terciario, mas as falhas principais estao ativasate hoje.O Rift Continental do Sudeste Brasileiro, compreendendo as bacias de Curitiba, Sao Paulo, Taubate,Resende e Volta Redonda, representaria outro importante testemunho de meso-escala (ou escala regional)do papel da neotectonica na evolucao da costa brasileira. Esta feicao foi originada durante o Paleogeno econtinuou ativa durante o Neogeno e Quaternario ate hoje, como uma manifestacao tardia e mais interior daReativacao Pos-paleozoica, cuja consequencia mais importante foi a origem do Oceano Atlântico Sul,simultaneamente a formacao das bacias marginais.Alem disso, as origens das nitidas diferenciacoes entre as porcoes norte e sul da linha costeira paulista,bem como da zona deprimida do Graben da Guanabara, ou as impressionantes feicoes do tipo-ria do NE dacosta do Para e os afloramentos suspensos de rochas praiais do litoral norte-riograndense poderiam estarrelacionadas a movimentos neotectonicos de micro-escala (ou escala local), mas elas necessitam de estudosmais especificos e detalhados.Aparentemente nao ha duvida sobre a relevância do papel desempenhado pela neotectonica na evolucaodo litoral brasileiro, no entanto muitos setores desta costa ainda nao foram suficientemente estudados. Poroutro lado, deve-se reconhecer que muitas dessas feicoes representam fenomeno de tectonica ressurgente,cuja origem remonta ao Pre-cambriano. | 2022-09-06T21:00:48.246Z |
53,494,356 | {
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} | Many river restoration projects fail. Inadequate project planning underpins many of the reasons given for failure (such as setting overly ambitious goals; selecting inappropriate sites and techniques; losing stakeholder motivation; and neglecting to monitor, assess, and document projects). Another major problem is the lack of an agreed guiding image to direct the activities aimed at restoring the necessary biophysical and ecological processes within the logistic constraints of on-ground works. Despite a rich literature defining the components of restoration project planning, restoration ecology currently lacks an explicit and logical means of moving from the initial project vision through to on-ground strategies. Yet this process is fundamental because it directly links the ecological goals of the project to the on-ground strategies used to achieve them. We present a planning process that explicitly uses an interdisciplinary mechanistic model of disturbance drivers and system responses to build from the initial project vision to the implementation of on-ground works. A worked example on the Upper Hunter River in southeastern Australia shows how understanding catchment history can reveal disturbance and response mechanisms, thus facilitating process-based restoration. | 2022-12-10T09:18:56.445Z |
123,508,174 | {
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"DOI": "10.1002/NME.1620200302",
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} | Special quadrature rules are described for elastic finite elements that have rq behaviour (0 < q < 1) directly induced in natural element co-ordinates. In general, the quadrature points and weights can vary with the exponent q. For two-dimensional problems with a square-root singularity (q = 1/2), the use of special quadrature results in significant improvements over regular Gauss quadrature. The development of special quadrature rules for three-dimensional elements is shown to be a difficult task. Several special case rules are developed and tested for a line-type singular element, and a precise rule is given for a point-type singular element in three dimensions. | 2022-12-18T01:37:56.355Z |
15,123,378 | {
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"DOI": "10.1109/TVLSI.2012.2210256",
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} | This brief presents a NAND Flash memory wear-leveling algorithm that explicitly uses memory raw bit error rate (BER) as the optimization target. Although NAND Flash memory wear-leveling has been well studied, all the existing algorithms aim to equalize the number of programming/erase cycles among all the memory blocks. Unfortunately, such a conventional design practice becomes increasingly suboptimal as inter-block variation becomes increasingly significant with the technology scaling. This brief presents a dynamic BER-based greedy wear-leveling algorithm that uses BER statistics as the measurement of memory block wear-out pace, and guides dynamic memory block data swapping to fully maximize the wear-leveling efficiency. Simulations have been carried out to quantitatively demonstrate its advantages over existing wear-leveling algorithms. | 2022-12-19T23:14:04.427Z |
14,071,660 | {
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"DOI": "10.1145/2364527.2364569",
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},
"license": null,
"status": "GREEN",
"url": "https://tel.archives-ouvertes.fr/tel-00624156/file/these.pdf"
} | Unmarshalling primitives in statically typed language require, in order to preserve type safety, to dynamically verify the compatibility between the incoming values and the statically expected type. In the context of programming languages based on parametric polymorphism and uniform data representation, we propose a relation of compatibility between (unmarshalled) memory graphs and types. It is defined as constraints over nodes of the memory graph. Then, we propose an algorithm to check the compatibility between a memory graph and a type. It is described as a constraint solver based on a rewriting system. We have shown that the proposed algorithm is sound and semi-complete in presence of algebraic data types, mutable data, polymorphic sharing, cycles, and functional values, however, in its general form, it may not terminate. We have implemented a prototype tailored for the OCaml compiler [17] that always terminates and still seems sufficiently complete in practice. | 2022-12-23T02:01:38.057Z |
237,422,440 | {
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"DOI": "10.1080/08830185.2021.1974856",
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} | Abstract Lactate used to be considered as a waste product of glucose metabolism. However, accumulating evidence has revealed its crucial role in regulating various biological and pathological processes. Hypoxia, inflammation, viral infection, and tumor promote the production of lactate. Then lactate activates G protein-coupled receptor 81 (GPR81) or shuttles across membranes by monocarboxylate-transporters (MCTs) to execute its intricate effects. Many studies highlighted the function of lactate in regulating dendritic cells, monocytes, natural killer cells, mast cells, T cells, tumor cells, fibroblasts, macrophages polarization, and the differentiation of Th1, Th17, MDSCs, Tregs; all of which play a role in maintaining the immune homeostasis of the host when challenged with the noxious stimuli. In this review, we summarized the influence of lactate in diverse tissue-specific cells, and discuss their effects on viral infection, acute inflammation, chronic inflammation, sepsis, and tumor immunosuppression. The goal of this review is to expose that lactate has a double-edged effect on host immunity and accompanying inflammatory reactions, which could be a potentially effective target for treating the tumor and multiple infectious diseases. GRAPHICAL ABSTRACT | 2022-12-28T18:14:09.089Z |
23,416,590 | {
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"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1469-8137.2010.03478.x"
} | • Lysine is a nutritionally important essential amino acid, but significant elevation of its levels in Arabidopsis seeds, by enhancing its synthesis and blocking its catabolism, causes a retardation of germination. Here, we hypothesized that this negative effect is associated with changes in primary metabolism and gene expression programs that are essential for early germination. • Seeds at different stages of germination sensu stricto of the seed-high-lysine genotype were subjected to detailed analysis of primary metabolism, using GC-MS, as well as microarray analysis and two-dimensional, isoelectric focusing, sodium dodecylsulfate polyacrylamide gel electrophoresis, to detect storage protein mobilization. • Our results exposed a major negative effect of the seed-specific increased lysine synthesis and knockout of its catabolism on the levels of a number of TCA cycle metabolites. This metabolic alteration also influences significantly the transcriptome, primarily attenuating the boost of specific transcriptional programs that are essential for seedling establishment, such as the onset of photosynthesis, as well as the turnover of specific transcriptional programs associated with seed embryonic traits. • Our results indicate that catabolism of the aspartic acid family of amino acids is an important contributor to the energy status of plants, and hence to the onset of autotrophic growth-associated processes during germination. | 2022-12-30T17:50:09.931Z |
88,442,464 | {
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"DOI": "10.2491/JJSTH1970.9.312",
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} | Recently von Willebrand Factor (VIII VWF) has been proved to be localized in vessel wall and in platelets, and synthesized in endothelical cells. We studied the effects of temperature and the time course of VIII VWF movement from platelets in vitro and discussed its significance in thrombogenesis.We observed ristocetin induced aggregation of 4 times washed platelets suspended in Tris buffer and stored at 4°C or 20°C for 48hrs. Platelet suspension stored at 20°C was induced slight aggregation by 1.5mg/ml of ristocetin in two hours and aggregability continued to increase gradually for 20hrs. After 24hrs. this aggregation decreased. Suspention stored at 4°C exhibited, however, a low grade of aggregation induced by 1.5mg/ml of Ristocetin after 20hrs. Aggregation increased after 24hrs. and 48hrs., but it was not intense as that of suspension stored at 20°C.The supernatant of these suspension, collected on 3, 5 and 24hrs. of both temperature was assayed on VIII VWF, VIII-antigen (VIII AGN) and antihemophilic factor (VIII AHF). The platelets from the same source was washed 4 times and disrupted by freezing and thawing. The supernatant of these disrupted platelets were also assayed on the VIII VWF, VIII AGN and VIII AHF (Table 1). Approximately 10% of VIII VWF activity and VIII-antigen were proved to bederivedfrom disrupted platelets. VIII VWF activity in the supernatant of stored platelets was demonstrated time dependent as showing in Table 1 and in Fig. 2.No antigenic activity was demonstrated in the supernatant by the assay method applied, however, we observed the antigenic activity in the supernatant of platelets stored at 20°C for 24hrs. it the concentration of platelets was high enough (106/μl).We also observed the inhibitory effects on its excretion by ASA, and glyclazide; the new antidiabetic agent. ASA (10-3, 10-4M) which inhibit potently the release reaction, did inhibit slightly and glyclazide (10-3, 10-4M) inhibited well this excretion. This result prompted us to imagine of some relation to the mechanism of the effect of this drug on the diabetic retinopathy, whose VIII VWF and VIII AGN increased significantly. We concluded that 1) there is fairly high VIII VWF in platelets, 2) this factor was excreted out of platelet by some mechanism other than the release reaction, 3) this excretion was inhibited by high concentration of ASA, and by glyclazide. | 2022-02-10T20:31:12.577Z |
171,173,966 | {
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"DOI": "10.1484/J.APOCRA.2.300867",
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} | In the middle of an exegetical debate in the Coptic version of the Acta Pilati, an enigmatic sentence refers to the eternal memory of Iobel (XVI,7). A new reading of this passage suggests seeing here an exclamation' By Jupiter Sumanus...' and proposes reinterpreting the historical context of this debate, during the IVth century. | 2022-02-08T16:57:53.797Z |
61,174,650 | {
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"DOI": "10.1109/WCICA.2000.859949",
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} | Robot soccer, as the ideal field for research of AI, robotics, and cybernetics, has become a hot topic among researchers. This paper gives a brief introduction of the RoboCup, including the basic rules of RoboCup, the competition environment, and typical research work over RoboCup. A simple comparison between RoboCup and FIRA is also given. | 2022-02-11T15:44:33.615Z |
1,806,482 | {
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"DOI": "10.1097/00006324-199903000-00016",
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} | BACKGROUND
The literature contains conflicting reports of the effects of topical anesthetics on tear film stability, with some consensus that unpreserved topical anesthetics are less likely to reduce tear film stability than preserved preparations. This experiment investigated the effect of unpreserved 0.4% benoxinate hydrochloride on tear thinning time (TTT), in parallel with "real time" corneal sensitivity assessment.
METHODS
Tear film stability was assessed (HIRCAL grid) in parallel with real time assessment of the pharmacological activity (NCCA) of unpreserved 0.4% benoxinate hydrochloride in normal eyes.
RESULTS
The anesthetic used did not significantly affect tear film stability. This finding is in agreement with previous investigators.
CONCLUSIONS
Unpreserved 0.4% benoxinate hydrochloride could be used to facilitate tear film stability assessment. The experimental protocol used could also be applied to investigate the temporal relationship between anesthesia and tear film stability with preserved topical anesthetics that have been found to decrease tear film stability. | 2022-09-10T10:35:17.748Z |
237,850,444 | {
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"DOI": "10.9734/IJMPCR/2021/V14I230125",
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} | Aim: This report highlights the use of doxycycline therapy other than the more standard regimen that includes an aminoglycoside in the management of enterococcal infection in patients with renal impairment without causing further damages to the kidney due to aminoglycoside therapy.
Presentation of Case: A case of enteroccocal septicemia in a 29-year-old woman who was admitted on account of acute kidney injury secondary to pregnancy induced hypertension in the setting of pre-eclampsia. She was referred from another centre where she had emergency caesarean section done on account of severe pre-eclampsia at 36 weeks gestational age. Blood culture yielded Enterococcus species. When other antibiotic regimen failed, she was started on doxycycline. Patient had good clinical response and was discharged 7 days after commencement of doxycycline.
Discussion: Enteroccoci have emerged as important agent of human disease largely because of their resistance to antimicrobial agents. They are important nosocomial pathogens capable of causing serious and potentially life-threatening infections, including sepsis. The incidence of enteroccocal infections, mainly hospital-acquired, has increased over the past 2 decades and isolates with novel mechanism of resistance to antimicrobial agents are more and more frequent. Furthermore, they have great capacity for transmitting these resistances to other species and even to other genera.
Conclusion: Doxycycline is a safe and effective alternative antibiotic for the treatment of enterococcal sepsis in patients with impaired renal status. | 2022-10-14T00:45:13.020Z |
29,205,251 | {
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"DOI": "10.1002/clc.20440",
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"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/clc.20440"
} | I don't make any claims to be an expert in managing patients after cardiac transplantation, but I do recall 2 patients which I believe make the point that times have changed since the beginning of cardiac transplantation. In 1968, a patient of mine underwent cardiac transplantation. This was the first transplantation done at Johns Hopkins, and I believe it was 99th in the world. This patient survived the surgery very well, left the hospital, and in 4 wk he was dead. Copyright © 2008 Wiley Periodicals, Inc. | 2022-11-18T01:08:46.207Z |
154,978,647 | {
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"DOI": "10.5539/JSD.V4N5P139",
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} | The phenomenal growth of our towns and cities has given rise to conurbation and metropolitan areas, with various planning problems such as traffic congestion, slum, shanty towns, waste management, housing, pollution, poverty and several others. There is no doubt that the impact of rapid population growth on housing development in a developing economy is usually a consequence of the push of the rural areas and the pull of the town. There is always an upsurge and conglomeration of people in city centres with the resultant effects on housing growth arising from acute unemployment. This growth and physical expansion of cities have been accompanied by unplanned urban sprawl, environmental pollution, deterioration, deficiencies in modern basic facilities, and general urban decay. As increased poverty and urbanization exert more pressures on urban facilities, most Nigerian cities tend to have lost their original dignity, social cohesion and administrative efficiency. Land Administration in Lagos State, over the last 25years cannot be described as being sustainable. Though, various tools might have been put in place concerning the administration of land, there are still a whole lot of problems being faced on and matters in the state. Planning for housing and setting standards for the regulation of building construction is a task that seems to overwhelm the relevant government authorities in Nigeria and other parts of the developing world. This paper therefore examines the planning laws and ordinances available in Nigeria, with specific reference to the new Lagos State Urban and Regional Planning and Development Law 2010, the types and levels of the Planning Authorities and Agencies responsible for the implementation of the laws. It also appraises their activities so far in the area of implementation, their challenges and lastly, makes recommendation for improvement. | 2022-11-01T15:32:47.651Z |
19,140,267 | {
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"DOI": "10.1021/acs.orglett.7b00601",
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} | A series of N2O-type benzopyrromethene boron complexes have been synthesized from the condensation of pyrrole, formylisoindole, and various boronic acids. These dyes have red/near-infrared absorption, high solution- and solid-state fluorescence, as well as good solubility in a variety of solvents due to the presence of axial-substituted groups that provide steric protection and prevent their possible aggregations. Two water-soluble derivatives with pyridinium ions were developed as near-infrared excitable mitochondrially localizing fluorescent probes. | 2022-12-12T17:05:15.152Z |
35,245,145 | {
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"DOI": "10.21037/atm.2017.05.01",
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"url": "https://europepmc.org/articles/pmc5599293?pdf=render"
} | Catheter-based interventional procedures have become an increasingly offered treatment option for older and high-risk patients, especially in those contraindicated for surgical heart valve repair or replacement, because of frailty and/or comorbidities. Besides aortic valve pathologies, there is a broad spectrum of diseases (rheumatic, degenerative, ischemic and infectious) that may affect the mitral valve in a population that is increasingly aging. | 2022-12-15T01:20:54.816Z |
52,271,462 | {
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"DOI": "10.2147/IJN.S167670",
"MAG": "2889103770",
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} | Background α-Mangostin is a major active compound of mangosteen (Garcinia mangostana L.) pericarp extract (MPE) that has potent antioxidant activity. Unfortunately, its poor aqueous solubility limits its therapeutic application. Purpose: This paper reports a promising approach to improve the clinical use of this substance through electrospinning technique. Methods Polyvinylpyrrolidone (PVP) was explored as a hydrophilic matrix to carry α-mangostin in MPE. Physicochemical properties of MPE:PVP nanofibers with various extract-to-polymer ratios were studied, including morphology, size, crystallinity, chemical interaction, and thermal behavior. Antioxidant activity and the release of α-mangostin, as the chemical marker of MPE, from the resulting fibers were investigated. Results It was obtained that the MPE:PVP nanofiber mats were flat, bead-free, and in a size range of 387–586 nm. Peak shifts in Fourier-transform infrared spectra of PVP in the presence of MPE suggested hydrogen bond formation between MPE and PVP. The differential scanning calorimetric study revealed a noticeable endothermic event at 119°C in MPE:PVP nanofibers, indicating vaporization of moisture residue. This confirmed hygroscopic property of PVP. The absence of crystalline peaks of MPE at 2θ of 5.99°, 11.62°, and 13.01° in the X-ray diffraction patterns of electrospun MPE:PVP nanofibers showed amorphization of MPE by PVP after being electrospun. The radical scavenging activity of MPE:PVP nanofibers exhibited lower IC50 value (55–67 µg/mL) in comparison with pure MPE (69 µg/mL). The PVP:MPE nanofibers tremendously increased the antioxidant activity of α-mangostin as well as its release rate. Applying high voltage in electrospinning process did not destroy the chemical structure of α-mangostin as indicated by retained in vitro antioxidant activity. The release rate of α-mangostin significantly increased from 35% to over 90% in 60 minutes. The release of α-mangostin from MPE:PVP nanofibers was dependent on α-mangostin concentration and particle size, as confirmed by the first-order kinetic model as well as the Hixson–Crowell kinetic model. Conclusion We successfully synthesized MPE:PVP nanofiber mats with enhanced antioxidant activity and release rate, which can potentially improve the therapeutic effects offered by MPE. | 2022-12-17T12:23:40.408Z |
126,171,352 | {
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"DOI": "10.1163/9789004332966_006",
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} | Although it is not younger than other areas of non-classical logic, paraconsistent logic has received full recognition only in recent years, largely due to the work of, among others, Newton da Costa, Graham Priest, Diderik Batens, and Jerzy Perzanowski. A logical system ? is paraconsistent if there is a set of ?-formulas ? ? {A} such that (i) in ? one may derive from ? both A and its negation, and (ii) the deductive closure of ? with respect to ? is different from the set of all formulas. If from ? one may derive a formula and its negation, ? is said to be syntactically inconsistent. But is every syntactically inconsistent set of formulas contradictory? In classical logic and many non-classical logics, every syntactically inconsistent set is unsatisfiable, that is, semantically inconsistent. If contradictoriness means semantical inconsistency, there is, up to logical equivalence, only one contradiction. In paraconsistent logics, there are usually many non-equivalent formulas representing the semantically unique contradiction in a non-paraconsistent logic. So when is a formula the contradiction of another formula, and, moreover, how does the notion of contradiction relate to the notions of contrariety and negation? | 2022-12-17T19:04:55.781Z |
153,840,603 | {
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"DOI": "10.1080/00905990903517819",
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},
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"url": "https://biblio.ugent.be/publication/839236/file/6825168.pdf"
} | This article examines Yugoslav national programs of ruling political elites and its concrete implementation in education policy in interwar Yugoslavia. It is argued that at the beginning of the period Yugoslavism was not inherently incompatible with or subordinate to Serbian, Croatian or to a lesser degree Slovenian national ideas. However, the concrete ways in which Yugoslavism was formulated and adopted by ruling elites discredited the Yugoslav national idea and resulted in increasing delineation and polarization in the continuum of national ideas available in Yugoslavia. Throughout the three consecutive periods of political rule under scrutiny, ruling elites failed to reach a wider consensus regarding the Yugoslav national idea or to create a framework within which a constructive elaboration of Yugoslav national identity could take place. By the end of the interwar period, the Yugoslav national idea had become linked exclusively to conservatism, centralism, authoritarianism and, for non-Serbian elites at least, Serbian hegemony. Other national ideas gained significance as ideas providing viable alternatives for the regime's Yugoslavism. | 2022-12-18T19:18:17.414Z |
249,137,197 | {
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"DOI": "10.1099/acmi.ac2021.po0069",
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"license": "CCBYNC",
"status": "GOLD",
"url": "https://doi.org/10.1099/acmi.ac2021.po0069"
} | A carbapenem-resistant strain, UL-CPE-01, was isolated from a domestic wastewater treatment plant and subjected to antibiotic susceptibility testing showing resistance to a wide range of antibiotics. Complete genome and bioinformatic analysis of UL-CPE-01 was performed to investigate the nature of its resistance determinants and the strain identified as Citrobacter pasteuriibased onANI score. Citrobacter spp. are part of the normal human and animal intestinal flora and the UL-CPE-01 Citrobacter pasteuriistrain detected here is closely related to Citrobacter freundii, which is an emerging opportunistic nosocomial pathogen. UL-CPE-01 showed both phenotypic and genotypic multiple resistance to aminoglycoside, β-lactams, sulfonamides, fluoroquinolone, rifampicin, phenicol and macrolide antibiotics. The UL-CPE-01 genome revealed 16 acquired antimicrobial resistance gene (ARGs) conferring resistance to eight different antibiotic groups: dfrA12 (trimethoprim); sul1 (sulfonamide); mph(A), mph(E) and msr(E) (macrolide); qnrB4 and aac(6′)-Ib-cr (fluoroquinolone); blaDHA-1, blaOXA-1, blaCMY-77,blaOXA-10, blaTEM-1B, blaKPC-2(β-lactams); arr-3 (rifampicin); catB3 and catA1 (chloramphenicol) and aac(6′)-Ib-cr, aadA2 and ant(2″)-Ia (aminoglycoside). The novel blaKPC-2 determinant was found to be associated with in a Tn4401-like element. | 2022-06-04T14:24:55.735Z |
224,864,898 | {
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"DOI": "10.1155/2020/1215032",
"MAG": "3085730827",
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},
"license": "CCBY",
"status": "GOLD",
"url": "https://downloads.hindawi.com/journals/ijp/2020/1215032.pdf"
} | In the article titled “Expanding Thermal Plasma Chemical Vapour Deposition of ZnO:Al Layers for CIGS Solar Cells” [1], there was an error in the references list, as reference number 4 cited a wrong author’s name (M. Jean) instead of Jonas Lahnemann, who is the actual author of that article [2]. Copyright © 2020 K. Sharma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | 2022-08-26T23:15:58.013Z |
155,010,625 | {
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"DOI": "10.1177/0021989407087828",
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} | This paper examines the 1988 murder of British tourist Julie Ward in Kenya's Maasai Mara Game Reserve. It explores the search for Julie Ward's killers and how it is narrated in the three books on the case: John Ward's The Animals Are Innocent: The Search for Julie's Killers (1991), Michael Hiltzik's A Death in Kenya: The Murder of Julie Ward (1991) and Jeremy Gavron's Darkness in Eden: The Murder of Julie Ward (1994). Both the search for Julie Ward's killers and the narration of the case in the three books are framed within a distinctly British colonial archive, which reads Kenya(ns) through the twin tropes of exoticism and the political jungle of the postcolonial state. The paper argues that their embedding in this colonial archive resulted in an epistemological disarticulation between the British and Kenyan players in the search for Julie Ward's killers, as certain Kenyan textualities remained illegible to the British. | 2022-09-03T10:12:40.091Z |
20,608,512 | {
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"DOI": "10.1203/00006450-197905000-00016",
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"license": null,
"status": "BRONZE",
"url": "https://www.nature.com/articles/pr1979170.pdf"
} | Summary: Purine metabolism and phosphoribosylpyrophosphate content of lymphocytes and erythrocytes were studied in an immunocompetent black male child with a total deficiency of erythrocyte and partial deficiency of lymphocyte adenosine deaminase. The partial genetic deficiency of adenosine deaminase was demonstrated in intact lymphocytes, and was approximately one third of the deaminating activity of control lymphocytes. Intact lymphocytes of the patient did not incorporate adenosine at a faster rate than those of control lymphocytes. The patient's erythrocytes deaminating activity was low and adenine ribonucleotide synthesis from adenosine was increased several fold, while adenine incorporation into purine ribonucleotides was comparable to that of control erythrocytes. Transfusion with packed erythrocytes temporarily improved the deaminating capacity of circulating erythrocytes, but did not reduce the elevated incorporation of adenosine into purine ribonucleotides.Phosphoribosylpyrophosphate content of the patient's lymphocytes and erythrocytes was not diminished. Incubation of erythrocytes with adenosine lowered phosphoribosylpyrophosphate content while incubation with phosphate increased phosphoribosylpyrophosphate content to the same extent in mutant and control erythrocytes.Speculation: The finding that the patient's lymphocytes can deaminate adenosine to some extent may explain why the rate of adenosine incorporation into purine ribonucleotides of his lymphocytes is not increased and immune function is not impaired. Deficiency of erythrocyte adenosine deaminase results in increased adenosine incorporation, but does not appear to interfere with immune functions. | 2022-09-07T14:26:39.316Z |
76,911,871 | {
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"DOI": "10.14288/1.0076944",
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} | Physical activity and adequate calcium intake have the potential to increase peak bone mass and reduce the incidence of osteoporosis later in life. This study investigated the effects of 18-months of weight training and calcium supplementation on adolescent bone mineral and bone size and the bone remodeling transient. After screening, 108 female volunteers, mean age 14.1 y, from 4 high schools were assigned to a non-exercise or exercise group, based on the school they attended. Exercise subjects were matched for weight, months past menarche and height to non-exercise subjects. Pairs were randomly given 1000 mg/d calcium supplement or placebo. Calcium and placebo pairs were matched to form blocks of 4 subjects forming 4 treatment groups: exercise/ calcium (EC), exercise/placebo (EP), no exercise/calcium (NC), no exercise/placebo (NP). The PRECEDE PROCEED model of health promotion program planning and evaluation was used to plan the intervention program. Exercise subjects strength trained, 3x/wk in 5 week cycles of 1 easy, 1 moderate, and 3 high intensity weeks. High intensity was 3 sets of 5-7 repetitions to fatigue. The nonexercising group was instructed to continue with their current activity level. Subjects recorded calcium/placebo intake, physical activity, weight training and menstrual cycles. Bone mineral content (BMC) and density (BMD) of whole body, hip and spine were measured using a Norland XR 26 dual-energy X-ray absorbtiometer initially, and at 6 and 18 months. Strength tests, anthropometry, dietary, lifestyle and program compliance questionnaires were also completed. | 2022-09-12T02:48:34.529Z |
121,822,450 | {
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"DOI": "10.1103/PHYSREVLETT.36.603",
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} | The electron-coupled phonon spectrum $alpha$$sup 2$F, lambda, and $mu$* have been determined for polycrystalline and high-purity, single-crystal niobium from tunnel junctions fabricated with three different counterelectrodes. All spectra compare well with phonon spectra extracted from neutron-scattering experiments. Values of lambda are BCS-like and $mu$* is always negative. Computer-modeling studies describing a niobiumlike material cannot generate an acceptable set of strong-coupling parameters. (AIP) | 2022-09-15T10:29:49.979Z |
232,354,982 | {
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"url": "http://minerva-access.unimelb.edu.au/bitstreams/002f46f3-94ef-510d-b392-05c178173a0a/download"
} | The delivery of family-centred practice (FCP) within Early Childhood Intervention Services (ECISs) for young children with a disability or development delay conceptualises that children's learning environments, parenting, family and community supports intersect to have the greatest impact on the developing child. The transdisciplinary key worker model is considered a best-practice approach within ECISs whereby staff work collaboratively across disciplinary boundaries to plan and implement services for children and their families. Research suggests families who have a key worker have better relationships with services, fewer unmet needs, better morale, more information about services, higher parental satisfaction and more parental involvement than those not receiving this service. Using a phenomenological qualitative design this study sought to understand transdisciplinary key workers' perspectives regarding the strengths and challenges to undertaking their role in providing services to children and families accessing an ECIS at a major disability service organisation, in light of the changing policy reform during the roll out of the National Disability Insurance Scheme in Australia. Purposive sampling was used to recruit key workers (n = 13) to participate in semi-structured interviews during 2015. Data were analysed using an inductive, thematic approach. Results revealed four main themes that impact on the effectiveness of key workers' service provision. These are broadly categorised as (a) Engagement with the workplace, (b) Engagement with clients, (c) Professional capacity and (d) Staff Wellbeing. The findings aligned with previous studies identifying sources of support and stress for disability services staff. They also provided new insights into key workers' lack of confidence in addressing parental mental health issues, despite operating under a family-centred approach. These findings informed the development of an intervention trial and evaluation to improve support for parent and staff wellbeing within a Victorian Disability Service with the aim of building their capacity to support children with a disability. | 2022-10-28T00:30:30.783Z |
252,685,934 | {
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"DOI": "10.3389/fcomp.2022.932342",
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"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fcomp.2022.932342/pdf"
} | Motor learning is based on the correct repetition of specific movements for their permanent storage in the central nervous system (CNS). Rehabilitation relies heavily on the repetition of specific movements, and game scenarios are ideal environments to build routines of repetitive exercises that have entertaining characteristics. In this respect, the gamification of the rehabilitation program, through the introduction of game-specific techniques and design concepts, has gained attention as a complementary or alternative to routine rehabilitation programs. A gamified rehabilitation program promises to gain the patient's attention, to reduce the monotony of the process and preserve motivation to attend, and to create virtual incentives through the game, toward maintaining compliance to the “prescribed” program. This is often achieved through goal-oriented tasks and real-time feedback in the form of points and other in-game rewards. This paper describes MILORD rehabilitation platform, an affordable technological solution, which aims to support health professionals and enable remote rehabilitation, while maintaining health service characteristics and monitoring. MILORD is an end-to-end platform that consists of an interactive computer game, utilizing a leap motion sensor, a centralized user management system, an analysis platform that processes the data generated by the game, and an analysis dashboard presenting a set of meaningful features that describe upper limb movement. Our solution facilitates the monitoring of the patients' progress and provides an alternative way to analyze hand movement. The system was tested with normal subjects and patients and experts to record user's experience, receive feedback, identify any problems, and understand the system's value in monitoring and support motion defect and progress. This small-scale study indicated the capacity of the analysis to quantify the movement in a meaningful way and express the differences between normal and pathological movement, and the user experience was positive with both patients and normal subjects. | 2022-10-07T00:25:25.119Z |
33,557,485 | {
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"DOI": "10.1093/HUMREP/14.5.1372",
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} | Heterotopic pregnancies are estimated to be less frequent than one in 30,000 if no assisted reproduction technologies are performed. Here we report a case which occurred in Tanzania. An abdominal pregnancy at term was first misdiagnosed as an ovarian tumour and diagnosed on the first post-partum day of the intrauterine fetus, which was delivered spontaneously. The abdominal pregnancy was then treated by laparotomy and removal of the placenta. The fetus was alive and healthy. The follow-up of the twins was normal. | 2022-12-14T11:15:46.679Z |
205,175,205 | {
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"DOI": "10.1063/1.4766363",
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"url": "https://europepmc.org/articles/pmc4108639?pdf=render"
} | Over 15 years ago, the ability to electrically detect and characterize individual polynucleotides as they are driven through a single protein ion channel was suggested as a potential method for rapidly sequencing DNA, base-by-base, in a ticker tape-like fashion. More recently, a variation of this method was proposed in which a nanopore would instead detect single nucleotides cleaved sequentially by an exonuclease enzyme in close proximity to one pore entrance. We analyze the exonuclease/nanopore-based DNA sequencing engine using analytical theory and computer simulations that describe nucleotide transport. The available data and analytical results suggest that the proposed method will be limited to reading <80 bases, imposed, in part, by the short lifetime each nucleotide spends in the vicinity of the detection element within the pore and the ability to accurately discriminate between the four mononucleotides. | 2022-12-19T13:47:17.717Z |
241,043,660 | {
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"DOI": "10.36628/ijhf.2021.0036",
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"PubMedCentral": "9536687"
},
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"status": "GREEN",
"url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536687"
} | https://e-heartfailure.org There have been continuous efforts to obtain epidemiologic data on heart failure (HF) in Korea. Four representative HF registries have been conducted simultaneously from 1987 until 2011. The Hallym HF registry is considered the first report on the epidemiology of HF in Korea.1) It was a retrospective cohort study involving 4 hospitals between 1987 and 1997 (n=1,657). Despite the long duration of follow-up and discrete prognosis according to the etiology of HF, the study had inherent limitations owing to its retrospective design. The subsequent study, the Korean Multicenter HF study, was a prospective, observational, multicenter registry from 9 hospitals and involved patients with acute HF between 1998 and 2003 (n=1,759).2) It was funded partly by the Korean Society of Cardiology and reported the cumulative 2-year mortality rate to be 76.4%. Subsequently, the Korean Heart Failure (KorHF) registry was conducted for patients with acute HF from 2004 to 2009.3) It was a national, observational, prospective, multicenter registry from 24 hospitals (n=3,200). It reported longer cumulative survival rates by 4 years after discharge. The Korean Society of Circulation equally supported the study in celebration of its 50th Anniversary. Finally, the Korean Acute Heart Failure (KorAHF) registry gathered the data of patients with acute HF from 2011 to 2014.4) It was also a prospective, observational, multicenter cohort study from 10 hospitals and was supported by Research of Korea Centers for Disease Control and Prevention (n=5,625). This study strictly predefined variables and clinical events and an independent committee audited the data, which provided more accurate data collection. These serial registries showed temporal changes in demographics, management, and clinical outcomes of patients hospitalized for HF in Korea. Moreover, over the years, the studies included more patients and longer follow-up duration and outcomes. Through the support of the society and the government, the studies have also expanded in scale. However, except for the KorHF registry, the other studies were limited by the fact that data were collected from only some centers around 10 or tertiary university hospitals, which do not reflect the nationwide actualities of HF in Korea. | 2022-12-20T10:15:07.974Z |
144,648,499 | {
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} | Those who have been involved in the formal education of Indians have assumed that the main purpose of the school is assimilation. The Indian would be better off, it was believed, if he could be induced, or forced, to adpot [sic] the white man's habits, skills, knowledge, language, values, religion, attitudes, and customs—or at least some of them. Assimilation, to be sure, is a reciprocal process, and in the course of it the white man has learned much from the Indian, so that today American culture is immeasurably enriched by items adopted from the Indian. But it was always the white man's way of life which must set the pattern. Formal education has been regarded as the most effective means for bringing about assimilation. (B. Berry, 1968, pp. 15-16). | 2022-12-31T19:17:48.387Z |
234,149,257 | {
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"DOI": "10.37755/JSBI.V17I2.319",
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} | Penelitian ini bertujuan untuk mengetahui bagaimana penerapan Strategi Pembelajaran Kooperatif (SPK) dalam menulis teks prosedur oleh siswa kelas XI SMA Negeri 1 Padang Tualang. Lokasi penelitian ini adalah di SMA Negeri 1 Padang Tualang yang berlokasi di Jalan Besar Batang Serangan Tanjung Putus Padang Tualang Kabupaten Langkat. Jenis penelitian ini adalah penelitian kualitatif, yang berguna untuk menerapkan bagaimana strategi pembelajaran kooperatif (SPK) dalam menulis teks prosedur oleh siswa kelas XI. Penelitian kualitatif ditujukan untuk memahami fenomena-fenomena sosial dari sudut atau perspektif partisipan. Instrumen dalam penelitian ini adalah Lembar pengamatan aktivitas guru dan siswa, Tes Hasil Belajar (THB) dan Angket Respon Siswa (Kuisioner). Hasil dari penelitian ini bahwa Strategi Pembelajaran Kooperatif (SPK) dalam menulis teks prosedur yang telah dilaksanakan di kelas XI SMA Negeri 1 Padang Tualang dapat meningkatkan hasil belajar siswa pada pembelajaran bahasa Indonesia. Hasil belajar siswa dapat terlihat Nilai rata-rata kelas hasil evaluasi akhir pertemuan II sebesar 78 naik sebesar 14 poin dari nilai rata-rata kelas pada pertemuan I sebesar 63,89. Sedangkan presentase ketuntasan belajar pada pertemuan II sebesar 89% naik 36% dari presentase ketuntasan belajar pada pertemuan I sebesar 52,77%. | 2022-01-27T03:04:06.138Z |
141,656,356 | {
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} | Charles and Kay C. Gaffoway were associated with the Institute on Mental Retardation and Inteffectual Development, }. F. Kennedy Center, George Peabody Coffege for Teachers, Nashvilfe, Tennessee, and Clover Bottom State Hospital and School, Donelson, Tennessee, when this articfe was written. Dr. Galfoway is presently Director of Developmental Programs and Mrs. Gaffoway is Speech Therapist at Eastern Nebraska Community Office of Retardation in Omaha. | 2022-08-20T09:46:02.947Z |
144,689,471 | {
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"DOI": "10.1159/000259096",
"MAG": "2070455041",
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} | The coincidence of substance abuse and schizophrenia is about 47% according to US American studies. European studies on the prevalence, consumption, behaviour and pattern are rare. Using a representat | 2022-09-12T22:22:22.580Z |
97,451,339 | {
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"DOI": "10.1002/CBER.19861190231",
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} | Direct O-Acylation of Hydroxylamine and N-Monosubstituted Hydroxylamines by 1-Benzoylimidazole
Under suitable conditions 1-benzoylimidazole (2) reacts with hydroxylamines 3 to give O-benzoylhydroxylamines 4, which are isolated as their hydrochlorides 5 in 55 – 83% yields. | 2022-09-14T20:46:31.084Z |
239,166,006 | {
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"status": "HYBRID",
"url": "http://journal.qitepinmath.org/index.php/seamej/article/view/65/60"
} | This is a companion paper and should be read with the earlier one (White, 2017) that focused mainly on Australian governmental policies. In this paper, a more classroom and student focus will be adopted while summarising a few of the salient points of the first paper. A brief listing of five different types of mathematical literacy is provided. The definition used by the Program for International Student Assessment (PISA) is selected andsome brief remarks are provided on this program. PISA items are presented in the form of word problems. If a country such as Australia or Indonesia wants to improve their PISA results then it would demand that some class time is devoted to the development of the abilities of younger students to handle word problems before they turn fifteen and are subjected to PISA. To support classroom teachers, Newman (1977, 1983) defined five specific mathematical literacy levels as crucial to performance on mathematical wordproblems: reading, comprehension, transformation, process skills, and encoding. Newman's Error Analysis (NEA) provides a framework for considering the reasons that underlay the difficulties students experience with mathematical word problems and a process that assists teachers to determine where misunderstandings occur. NEA also provides directions for where teachers could target effective teaching strategies to overcome them. There is a brief discussion of strategies to assist students improve theirmathematical literacy. | 2022-12-11T05:57:10.879Z |
46,901,706 | {
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"DOI": "10.1029/94JE03079",
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} | The sensitivity of the Martian atmospheric circulation to a number of poorly known or strongly varying parameters (surface roughness length, atmospheric optical depth, CO2 ice albedo, and thermal emissivity) is investigated through experiments performed with the Martian version of the atmospheric general circulation model of Laboratoire de Meteorologie Dynamique, with a rather coarse horizontal resolution (a grid with 32 points in longitude and 24 points in latitude). The results are evaluated primarily on the basis of comparisons with the surface pressure records of the Viking mission. To that end, the records are decomposed into long-period seasonal variations due to mass exchange with the polar caps and latitudinal redistribution of mass, and short-period variations due to transient longitudinally propagating waves. The sensitivity experiments include a 5-year control simulation and shorter simulations (a little longer than 1 year) performed with “perturbed” parameter values. The main conclusions are that (1) a change of horizontal resolution (twice as many points in each direction) mostly affects the transient waves, (2) surface roughness lengths have a significant impact on the near-surface wind and, as a matter of consequence, on the latitudinal redistribution of mass, (3) atmospheric dust optical depth has a significant impact on radiative balance and dynamics, and (4) CO2 ice albedo and thermal emissivity strongly influence mass exchange between the atmosphere and the polar caps. In view of this last conclusion, an automatic procedure is implemented through which the albedo and emissivity of each of the two polar caps are determined, together with the total (i.e., including the caps) atmospheric CO2 content, in such a way as to get the closest fit of the model to the Viking pressure measurements. | 2022-12-19T10:40:18.330Z |
3,884,712 | {
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"DOI": "10.1021/acssynbio.7b00256",
"MAG": "2769934385",
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} | Epidemiological data confirmed a strong correlation between regular consumption of cruciferous vegetables and lower cancer risk. This cancer preventive property is mainly attributed to the glucosinolate products, such as glucoraphanin found in broccoli that is derived from methionine. Here we report the first successful reconstruction of the complete biosynthetic pathway of glucoraphanin from methionine in Escherichia coli via gene selection, pathway design, and protein engineering. We used branched-chain amino transferase 3 to catalyze two transamination steps to ensure the purity of precursor molecules and used cysteine as a sulfur donor to simplify the synthesis pathway. Two chimeric cytochrome P450 enzymes were engineered and expressed in E. coli functionally. The original plant C-S lyase was replaced by the Neurospora crassa hercynylcysteine sulfoxide lyase. Other pathway enzymes were successfully mined from Arabidopsis thaliana, Brassica rapa, and Brassica oleracea. Biosynthesis of glucoraphanin upon coexpression of the optimized enzymes in vivo was confirmed by liquid chromatography-tandem mass spectrometry analysis. No other glucosinolate analogues (except for glucoiberin) were identified that could facilitate the downstream purification processes. Production of glucoraphanin in this study laid the foundation for microbial production of such health-beneficial glucosinolates in a large-scale. | 2022-12-28T16:11:48.902Z |
215,748,230 | {
"externalids": {
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"DOI": "10.1002/cam4.3045",
"MAG": "3015963259",
"PubMedCentral": "7300425"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.3045"
} | Gut microbiota (GM) of patients with liver cancer is disordered, and syet no study reported the GM distribution of liver cirrhosis‐induced HCC (LC‐HCC) and nonliver cirrhosis‐induced HCC (NLC‐HCC). In this study, we aimed to characterize gut dysbiosis of LC‐HCC and NLC‐HCC to elucidate the role of GM in the pathogenesis of HCC. | 2023-01-01T17:50:24.655Z |
187,243,723 | {
"externalids": {
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"ArXiv": null,
"DOI": "10.5965/2357724x06102018103",
"MAG": "2888739251",
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},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://doi.org/10.5965/2357724x06102018103"
} | Este artigo tem como objetivo apresentar o jogo ASMDP como um instrumento para contribuir para o ensino de Expressoes Numericas. Para isso, destacamos os materiais reciclaveis como recurso para construcao do jogo, visto que ha uma preocupacao cada vez maior com a sustentabilidade e em como reutilizar essas materias primas de maneira eficaz. Para fundamentar a analise do jogo com um instrumento para o processo de ensino-aprendizagem das Expressoes Numericas, faremos uso da Teoria da Abordagem Instrumental, proposta por Rabardel (1995). Observamos que este jogo e um aliado importante no estimulo de calculos mentais, pois contribuiu para o desenvolvimento do raciocinio aritmetico, uma vez que ajuda a descobrir propriedades das operacoes e dos numeros, possibilitando a mobilizacao dos conteudos estudados na busca de solucoes para o jogo. | 2022-01-24T22:28:21.527Z |
157,615,594 | {
"externalids": {
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"ArXiv": null,
"DOI": "10.30742/perspektif.v10i2.321",
"MAG": "2625205118",
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},
"license": "CCBYSA",
"status": "HYBRID",
"url": "https://doi.org/10.30742/perspektif.v10i2.321"
} | Subjects involved in criminal law are people and corporation. In banking crime when a corporate involved the law enforcement is frequently less cared about. Therefore, it will be a need to do further study on how a banking law regulates the corporation crime in Indonesia. Corporation in Banking Law has a broader meaning than in Civil Law A form of corporation crime is raising fund from the community without any license from Central Bank of Indonesia, Bank Indonesia. | 2022-01-27T07:49:42.014Z |
76,517,811 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5631/jibirinsuppl1986.1998.Supplement98_10",
"MAG": "2335061185",
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},
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} | The efficacy of conventional drugs has been limited in the treatment of xerostoma, lingual pain and abnormal sensations in the throat due to psychosomatic disorders. In addition to these conventional therapies, various Kampo prescriptions have been administered to patients with uncontrollable diseases of the oral cavity, pharynx and larynx. For example, Bakumondo-to and Byaldcoka-ninjin-to have been used for the treatment of xerostomia, Oren-to for lingual pain, Saiboku-to for abnormal sensations in the throat. Furthermore, Juzen-taiho-to has also been used in cancer patients to improve their immunological status after the primary curative therapy. The underlying mechanisms and clinical efficacy of each type of Kampo medicine were analyzed based on the pharmacological actions of each of the herbal components, and we report here our recent clinical experiences. In addition, the use of Kampo for refractory diseases and complaints resistant to conventional treatments is discussed. | 2022-02-11T06:21:45.953Z |
6,729,945 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/IJC.2910240113",
"MAG": "2057315849",
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},
"license": null,
"status": null,
"url": null
} | Herpesvirus papio (HVP) is an indigenous B‐lymphotropic virus of baboons (Papio sp.) present in latent form in baboon lymphoblastoid cell lines. It shares cross‐reacting viral capsid and early antigens with the Epstein‐Barr virus (EBV), and HVP DNA and EBV DNA show partial sequence homology. EBV‐specific complementary RNA was employed here as a probe to investigate the physical state of the HVP DNA component in baboon lymphoblastoid cells after fractionation of cellular DNA by density gradient centrifugation. Five virus‐producing cultures contained both free and integrated HVP DNA sequences while one non‐producing cell line had two or three viral genome equivalents per cell in an apparently integrated form. Further analysis of one virus‐producing line showed that the free HVP DNA fraction was composed of both linear and circular viral DNA. Contour length measurements of HVP circular DNA molecules by electron microscopy revealed that they were similar in length to the EBV circular DNA present in human lymphoblastoid cells. | 2022-07-27T00:34:52.046Z |
16,379,036 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/HIPC.1997.634499",
"MAG": "2152461443",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | The theoretical available instruction level parallelism in most benchmark is very high. Vulnerability is related to the difficulty with which we can extract this parallelism with finite resources. This study characterizes the vulnerability of parallelism to resource constraints by scheduling dynamic dependence graphs (DDGs) from traces of several benchmarks using different scheduling algorithms and different number of functional units. It is observed that the execution time of the DDGs does not vary significantly with low-level scheduling algorithms like lazy, slack, etc. Measures of vulnerability based on slack and load were also considered. Although Accslk-Load, which uses a combination of accurate slack and load to make a prediction, has a prediction accuracy of about 85%, the prediction rate is only 42%. On the other hand, even though the prediction accuracy of /spl sigma/(L/sup x/), the standard deviation in the load, is not as high, there is a prediction in all the cases. The DDG execution time is also found to be most vulnerable to the functional unit with the greatest /spl sigma/(L/sub x/). | 2022-07-31T04:21:52.770Z |
96,577,326 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1246/BCSJ.58.3395",
"MAG": "2062754828",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | The N-nitroso group on N-nitrososulfonamides was substituted for the acetyl group in chloroform to give N-acetylsulfonamides in moderate yields. | 2022-09-13T05:04:51.477Z |
138,812,866 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2346/1.2167171",
"MAG": "2151744840",
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},
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"url": null
} | Treads made with emulsion styrene butadiene copolymer (SBR), solution SBR, polybutadieme (BR), and a 60, 40 emulsion SBR/BR mixture were built as four-way tread sections on G78-15 belted bias tires, which were driven over both concrete and gravel-textured highways and on a small, circular, concrete test track. The tires were front mounted. When driven on concrete highway, all except the BR tread had either crumbled- or liquid-appearing surfaces, thought to have been formed by mechanical degradation or fatigue. When cornered on concrete, these materials formed small cyindrical particles or rolls. The BR tread had a smooth, granular-textured surface when driven on concrete highway and a ridge or sawtooth abrasion pattern when cornered on concrete. All the materials appeared rough and torn when run on gravel-textured highway. The differences in wear surface formed on BR tread and the other three are thought to be due primarily to the relatively high resilience of BR. /Author/ | 2022-09-15T04:33:27.789Z |
128,773,718 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1029/GL017I004P00477",
"MAG": "2083446786",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | This paper reports N2O measurements obtained by the Airborne Tunable Laser Absorption Spectrometer from 14 flights of the NASA ER-2 aircraft during the 1989 Airborne Arctic Stratospheric Expedition field campaign. In the altitude range expected for ozone loss, N2O has a long photochemical lifetime, making it an excellent tracer of lower stratospheric air motions. As in the southern hemisphere, the zonal wind speed maximum and large gradients of potential vorticity and N2O identify the vortex edge. The N2O profiles inside the vortex indicate net descent relative to outside the vortex and to the summer polar lower stratosphere. The descent of the N2O profile during the Arctic night relative to the summer profile is comparable to the downward shift in the vertical profile observed in the 1987 Antarctic winter vortex. Winter profiles at the poles are very similar above the 435 K potential temperature surface, but divergent below. | 2022-12-09T10:50:11.382Z |
137,400,595 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1745-4603.1996.TB00078.X",
"MAG": "2037799643",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | The structural properties of pasta have been characterized based on sound emisison which generally accompanies rupture of brittle products. This paper presents the principal evolution tendency of the different mechanical and acoustical parameters by varying the relative humidity of the product, and the correlation existing between these two parameters. The correlations suggest that sound emission during rupture may well be utilized to characterize a given product in parallel to or in replacement of commonly measured mechanical properties. | 2022-12-12T10:31:14.576Z |
143,275,639 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/01490409509513239",
"MAG": "1963884752",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Abstract People recreating outdoors (at an urban, park) and people recreating indoors (in their homes) assessed their moods at the start, middle, and end of their brief (less than 2‐hr) leisure experiences. Moods changed slightly but significantly, and some of these changes were consistent with predictions that leisure reduces stress. Contrary to expectations, recreating near nature produced no more restoration than did recreating indoors, away from nature. | 2022-12-13T13:41:37.048Z |
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