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- ---
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- license: apache-2.0
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- ---
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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+ ---
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+ license: apache-2.0
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+ library_name: transformers
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+ pipeline_tag: text-generation
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+ tags:
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+ - biology
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+ - text-generation-inference
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+ ---
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+
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+ ## AptaGPT
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+
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+ AptaGPT is a generative pre-trained language model for aptamer design. The model focuses on the generation of a new sequence space of aptamers, trained and fine-tuned using the third and sixth round of SELEX data for B cell maturation antigen (BCMA).
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+
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+ ## Dataset
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+
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+ AptaGPT was pre-trained using a large dataset consisting of 108,229,900 sequences from the third round of the SELEX process targeting BCMA. This extensive dataset provided a robust foundation for learning generalized patterns in aptamer sequences. For fine-tuning, the model utilized 9,350 sequences from the sixth round of SELEX. All aptamer sequences used for both pre-training and fine-tuning are 35 nucleotides in length.
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+
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+ ## Requirements
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+
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+ Before running the AptaGPT model, the following Python dependencies need to be installed:
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+ ```bash
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+ pip install transformers sentencepiece
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+ ```
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+
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+ ## Usage Examples
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+
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+ To load the model form hugging face:
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+
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+ ```python
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+ from transformers import pipeline
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+ model = pipeline('text-generation', model="tmbj-aidd/aptagpt-bcma")
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+ ```
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+
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+ To generate aptamer sequences:
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+
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+ ```python
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+ sequences = model("<|endoftext|>",
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+ max_length=15,
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+ do_sample=True,
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+ top_k=700,
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+ repetition_penalty=1.2,
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+ num_return_sequences=10,
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+ )
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+ print(sequences)
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+ ```