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rjac
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biobert-ner-diseases-dataset

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11
[ "Regular", "audiologic", "evaluation", "is", "imperative", "in", "all", "thalassemic", "patients", "so", "that", "early", "changes", "may", "be", "recognized", "and", "treatment", "may", "be", "judiciously", "adjusted", "in", "order", "to", "prevent", "or", "reverse", "hearing", "impairment", "." ]
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BC5CDR-1178
[ "Individual", "differences", "in", "renal", "ACE", "activity", "in", "healthy", "rats", "predict", "susceptibility", "to", "adriamycin", "-", "induced", "renal", "damage", "." ]
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BC5CDR-1179
[ "The", "implications", "of", "these", "findings", "are", "discussed", "with", "particular", "emphasis", "upon", "conducting", "psychopharmacological", "challenge", "tests", "in", "rodents", "." ]
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BC5CDR-118
[ "BACKGROUND", ":", "In", "man", ",", "differences", "in", "angiotensin", "-", "converting", "enzyme", "(", "ACE", ")", "levels", ",", "related", "to", "ACE", "(", "I", "/", "D", ")", "genotype", ",", "are", "associated", "with", "renal", "prognosis", "." ]
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BC5CDR-1180
[ "This", "raises", "the", "hypothesis", "that", "individual", "differences", "in", "renal", "ACE", "activity", "are", "involved", "in", "renal", "susceptibility", "to", "inflicted", "damage", "." ]
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BC5CDR-1181
[ "Therefore", ",", "we", "studied", "the", "predictive", "effect", "of", "renal", "ACE", "activity", "for", "the", "severity", "of", "renal", "damage", "induced", "by", "a", "single", "injection", "of", "adriamycin", "in", "rats", "." ]
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BC5CDR-1182
[ "METHODS", ":", "Renal", "ACE", "activity", "(", "Hip", "-", "His", "-", "Leu", "cleavage", "by", "cortical", "homogenates", ")", "was", "determined", "by", "renal", "biopsy", "in", "27", "adult", "male", "Wistar", "rats", "." ]
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BC5CDR-1183
[ "After", "1", "week", "of", "recovery", ",", "proteinuria", "was", "induced", "by", "adriamycin", "[", "1", ".", "5", "mg", "/", "kg", "intravenously", "(", "i", ".", "v", ".", ")", "n", "=", "18", ";", "controls", ",", "saline", "i", ".", "v", ".", "n", "=", "9", "]", "." ]
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BC5CDR-1184
[ "Proteinuria", "was", "measured", "every", "2", "weeks", "." ]
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BC5CDR-1185
[ "After", "12", "weeks", ",", "rats", "were", "sacrificed", "and", "their", "kidneys", "harvested", "." ]
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BC5CDR-1186
[ "RESULTS", ":", "As", "anticipated", ",", "adriamycin", "elicited", "nephrotic", "range", "proteinuria", ",", "renal", "interstitial", "damage", "and", "mild", "focal", "glomerulosclerosis", "." ]
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BC5CDR-1187
[ "Baseline", "renal", "ACE", "positively", "correlated", "with", "the", "relative", "rise", "in", "proteinuria", "after", "adriamycin", "(", "r", "=", "0", ".", "62", ",", "P", "<", "0", ".", "01", ")", ",", "renal", "interstitial", "alpha", "-", "smooth", "muscle", "actin", "(", "r", "=", "0", ".", "49", ",", "P", "<", "0", ".", "05", ")", ",", "interstitial", "macrophage", "influx", "(", "r", "=", "0", ".", "56", ",", "P", "<", "0", ".", "05", ")", ",", "interstitial", "collagen", "III", "(", "r", "=", "0", ".", "53", ",", "P", "<", "0", ".", "05", ")", ",", "glomerular", "alpha", "-", "smooth", "muscle", "actin", "(", "r", "=", "0", ".", "74", ",", "P", "<", "0", ".", "01", ")", "and", "glomerular", "desmin", "(", "r", "=", "0", ".", "48", ",", "P", "<", "0", ".", "05", ")", "." ]
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BC5CDR-1188
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BC5CDR-1189
[ "Hemolysis", "of", "human", "erythrocytes", "induced", "by", "tamoxifen", "is", "related", "to", "disruption", "of", "membrane", "structure", "." ]
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BC5CDR-119
[ "In", "controls", ",", "no", "predictive", "values", "for", "renal", "parameters", "were", "observed", "." ]
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BC5CDR-1190
[ "CONCLUSION", ":", "Individual", "differences", "in", "renal", "ACE", "activity", "predict", "the", "severity", "of", "adriamycin", "-", "induced", "renal", "damage", "in", "this", "outbred", "rat", "strain", "." ]
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BC5CDR-1191
[ "This", "supports", "the", "assumption", "that", "differences", "in", "renal", "ACE", "activity", "predispose", "to", "a", "less", "favourable", "course", "of", "renal", "damage", "." ]
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BC5CDR-1192
[ "Recurrent", "acute", "interstitial", "nephritis", "induced", "by", "azithromycin", "." ]
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BC5CDR-1193
[ "A", "14", "-", "year", "-", "old", "girl", "is", "reported", "with", "recurrent", ",", "azithromycin", "-", "induced", ",", "acute", "interstitial", "nephritis", "." ]
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BC5CDR-1194
[ "The", "second", "episode", "was", "more", "severe", "than", "the", "first", ";", "and", "although", "both", "were", "treated", "with", "intensive", "corticosteroid", "therapy", ",", "renal", "function", "remained", "impaired", "." ]
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BC5CDR-1195
[ "Although", "most", "cases", "of", "antibiotic", "induced", "acute", "interstitial", "nephritis", "are", "benign", "and", "self", "-", "limited", ",", "some", "patients", "are", "at", "risk", "for", "permanent", "renal", "injury", "." ]
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BC5CDR-1196
[ "Spironolactone", "-", "induced", "renal", "insufficiency", "and", "hyperkalemia", "in", "patients", "with", "heart", "failure", "." ]
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BC5CDR-1197
[ "BACKGROUND", ":", "A", "previous", "randomized", "controlled", "trial", "evaluating", "the", "use", "of", "spironolactone", "in", "heart", "failure", "patients", "reported", "a", "low", "risk", "of", "hyperkalemia", "(", "2", "%", ")", "and", "renal", "insufficiency", "(", "0", "%", ")", "." ]
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BC5CDR-1198
[ "Because", "treatments", "for", "heart", "failure", "have", "changed", "since", "the", "benefits", "of", "spironolactone", "were", "reported", ",", "the", "prevalence", "of", "these", "complications", "may", "differ", "in", "current", "clinical", "practice", "." ]
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BC5CDR-1199
[ "Further", "studies", "on", "effects", "of", "irrigation", "solutions", "on", "rat", "bladders", "." ]
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BC5CDR-12
[ "Tamoxifen", "(", "TAM", ")", ",", "the", "antiestrogenic", "drug", "most", "widely", "prescribed", "in", "the", "chemotherapy", "of", "breast", "cancer", ",", "induces", "changes", "in", "normal", "discoid", "shape", "of", "erythrocytes", "and", "hemolytic", "anemia", "." ]
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BC5CDR-120
[ "We", "therefore", "sought", "to", "determine", "the", "prevalence", "and", "clinical", "associations", "of", "hyperkalemia", "and", "renal", "insufficiency", "in", "heart", "failure", "patients", "treated", "with", "spironolactone", "." ]
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BC5CDR-1200
[ "METHODS", ":", "We", "performed", "a", "case", "control", "study", "of", "heart", "failure", "patients", "treated", "with", "spironolactone", "in", "our", "clinical", "practice", "." ]
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BC5CDR-1201
[ "Cases", "were", "patients", "who", "developed", "hyperkalemia", "(", "K", "(", "+", ")", ">", "5", ".", "0", "mEq", "/", "L", ")", "or", "renal", "insufficiency", "(", "Cr", ">", "or", "=", "2", ".", "5", "mg", "/", "dL", ")", ",", "and", "they", "were", "compared", "to", "2", "randomly", "selected", "controls", "per", "case", "." ]
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BC5CDR-1202
[ "Clinical", "characteristics", ",", "medications", ",", "and", "serum", "chemistries", "at", "baseline", "and", "follow", "-", "up", "time", "periods", "were", "compared", "." ]
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BC5CDR-1203
[ "RESULTS", ":", "Sixty", "-", "seven", "of", "926", "patients", "(", "7", ".", "2", "%", ")", "required", "discontinuation", "of", "spironolactone", "due", "to", "hyperkalemia", "(", "n", "=", "33", ")", "or", "renal", "failure", "(", "n", "=", "34", ")", "." ]
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BC5CDR-1204
[ "Patients", "who", "developed", "hyperkalemia", "were", "older", "and", "more", "likely", "to", "have", "diabetes", ",", "had", "higher", "baseline", "serum", "potassium", "levels", "and", "lower", "baseline", "potassium", "supplement", "doses", ",", "and", "were", "more", "likely", "to", "be", "treated", "with", "beta", "-", "blockers", "than", "controls", "(", "n", "=", "134", ")", "." ]
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BC5CDR-1205
[ "Patients", "who", "developed", "renal", "insufficiency", "had", "lower", "baseline", "body", "weight", "and", "higher", "baseline", "serum", "creatinine", ",", "required", "higher", "doses", "of", "loop", "diuretics", ",", "and", "were", "more", "likely", "to", "be", "treated", "with", "thiazide", "diuretics", "than", "controls", "." ]
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BC5CDR-1206
[ "CONCLUSIONS", ":", "Spironolactone", "-", "induced", "hyperkalemia", "and", "renal", "insufficiency", "are", "more", "common", "in", "our", "clinical", "experience", "than", "reported", "previously", "." ]
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BC5CDR-1207
[ "This", "difference", "is", "explained", "by", "patient", "comorbidities", "and", "more", "frequent", "use", "of", "beta", "-", "blockers", "." ]
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BC5CDR-1208
[ "Acute", "reserpine", "and", "subchronic", "haloperidol", "treatments", "change", "synaptosomal", "brain", "glutamate", "uptake", "and", "elicit", "orofacial", "dyskinesia", "in", "rats", "." ]
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BC5CDR-1209
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BC5CDR-121
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BC5CDR-1210
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BC5CDR-1211
[ "Reserpine", "injection", "(", "one", "dose", "of", "1", "mg", "/", "kg", "s", ".", "c", ".", ")", "every", "other", "day", "for", "3", "days", "caused", "a", "significant", "increase", "in", "vacuous", "chewing", ",", "tongue", "protrusion", "and", "duration", "of", "facial", "twitching", ",", "compared", "to", "the", "control", "." ]
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BC5CDR-1212
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BC5CDR-1213
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BC5CDR-1214
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BC5CDR-1215
[ "Importantly", ",", "a", "decrease", "in", "glutamate", "uptake", "correlates", "negatively", "with", "an", "increase", "in", "the", "incidence", "of", "orofacial", "diskinesia", "." ]
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BC5CDR-1216
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BC5CDR-1217
[ "Ceftriaxone", "-", "associated", "biliary", "pseudolithiasis", "in", "paediatric", "surgical", "patients", "." ]
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BC5CDR-1218
[ "It", "is", "well", "known", "that", "ceftriaxone", "leads", "to", "pseudolithiasis", "in", "some", "patients", "." ]
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BC5CDR-1219
[ "TAM", "induces", "hemolysis", "of", "erythrocytes", "as", "a", "function", "of", "concentration", "." ]
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BC5CDR-122
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BC5CDR-1220
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BC5CDR-1221
[ "Fifty", "children", "who", "were", "given", "ceftriaxone", "were", "evaluated", "by", "serial", "abdominal", "sonograms", "." ]
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BC5CDR-1222
[ "Of", "those", ",", "13", "(", "26", "%", ")", "developed", "biliary", "pathology", "." ]
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BC5CDR-1223
[ "Comparison", "of", "the", "patients", "with", "or", "without", "pseudolithiasis", "revealed", "no", "significant", "difference", "with", "respect", "to", "age", ",", "sex", ",", "duration", "of", "the", "treatment", "and", "starvation", "variables", "." ]
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BC5CDR-1224
[ "After", "cessation", "of", "the", "treatment", ",", "pseudolithiasis", "resolved", "spontaneously", "within", "a", "short", "period", "." ]
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BC5CDR-1225
[ "The", "incidence", "of", "pseudolithiasis", "is", "not", "affected", "by", "fasting", "." ]
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BC5CDR-1226
[ "Coronary", "aneurysm", "after", "implantation", "of", "a", "paclitaxel", "-", "eluting", "stent", "." ]
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BC5CDR-1227
[ "Formation", "of", "coronary", "aneurysm", "is", "a", "rare", "complication", "of", "stenting", "with", "bare", "metal", "stents", ",", "but", "based", "on", "experimental", "studies", "drug", "-", "eluting", "stents", "may", "induce", "toxic", "effects", "on", "the", "vessel", "wall", "with", "incomplete", "stent", "apposition", ",", "aneurysm", "formation", "and", "with", "the", "potential", "of", "stent", "thrombosis", "or", "vessel", "rupture", "." ]
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BC5CDR-1228
[ "We", "present", "a", "43", "-", "year", "-", "old", "man", "who", "developed", "a", "coronary", "aneurysm", "in", "the", "right", "coronary", "artery", "6", "months", "after", "receiving", "a", "paclitaxel", "-", "eluting", "stent", "." ]
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BC5CDR-1229
[ "The", "extension", "of", "hemolysis", "is", "variable", "with", "erythrocyte", "samples", ",", "but", "12", ".", "5", "microM", "TAM", "induces", "total", "hemolysis", "of", "all", "tested", "suspensions", "." ]
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BC5CDR-123
[ "The", "patient", "was", "asymptomatic", "and", "the", "aneurysm", "was", "detected", "in", "a", "routine", "control", "." ]
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BC5CDR-1230
[ "Angiography", "and", "intracoronary", "ultrasound", "demonstrated", "lack", "of", "contact", "between", "stent", "and", "vessel", "wall", "in", "a", "15", "-", "mm", "long", "segment", "with", "maximal", "aneurysm", "diameter", "of", "6", ".", "0", "mm", "." ]
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BC5CDR-1231
[ "The", "patient", "was", "successfully", "treated", "with", "a", "graft", "stent", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
BC5CDR-1232
[ "Causes", "of", "acute", "thrombotic", "microangiopathy", "in", "patients", "receiving", "kidney", "transplantation", "." ]
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BC5CDR-1233
[ "OBJECTIVES", ":", "Thrombotic", "microangiopathy", "is", "a", "well", "-", "known", "problem", "in", "patients", "following", "renal", "transplantation", "." ]
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BC5CDR-1234
[ "In", "postrenal", "transplantation", ",", "thrombotic", "microangiopathy", "is", "often", "a", "reflection", "of", "hemolytic", "uremic", "syndrome", "." ]
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BC5CDR-1235
[ "We", "aimed", "to", "determine", "the", "causes", "of", "thrombotic", "microangiopathy", "in", "a", "population", "of", "renal", "transplantation", "recipients", "and", "discuss", "the", "literature", "." ]
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BC5CDR-1236
[ "MATERIALS", "AND", "METHODS", ":", "We", "investigated", "the", "causes", "of", "thrombotic", "microangiopathy", "during", "a", "1", "-", "year", "period", ",", "from", "June", "2003", "to", "June", "2004", ",", "at", "the", "King", "Fahad", "National", "Guard", "Hospital", "in", "Riyadh", ",", "Saudi", "Arabia", ",", "by", "reviewing", "the", "slides", "of", "all", "transplant", "biopsies", "(", "n", "=", "25", ")", "performed", "during", "this", "interval", "." ]
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BC5CDR-1237
[ "Pre", "-", "and", "posttransplant", "crossmatching", "was", "done", "when", "possible", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
BC5CDR-1238
[ "RESULTS", ":", "Five", "cases", "of", "thrombotic", "microangiopathy", "were", "found", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 0, 0, 0 ]
BC5CDR-1239
[ "Despite", "inducing", "extensive", "erythrocyte", "lysis", ",", "TAM", "does", "not", "shift", "the", "osmotic", "fragility", "curves", "of", "erythrocytes", "." ]
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BC5CDR-124
[ "Three", "of", "these", "cases", "were", "from", "the", "25", "transplantations", "performed", "at", "King", "Fahad", "National", "Guard", "Hospital", ",", "while", "the", "other", "2", "transplantations", "had", "been", "performed", "abroad", "and", "were", "referred", "to", "us", "for", "follow", "-", "up", "." ]
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BC5CDR-1240
[ "Three", "cases", "were", "related", "to", "cyclosporine", ",", "and", "1", "case", "was", "secondary", "to", "both", "cyclosporine", "and", "tacrolimus", "." ]
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BC5CDR-1241
[ "The", "fifth", "case", "had", "features", "of", "thrombotic", "microangiopathy", "related", "to", "an", "antiphospholipid", "syndrome", "in", "a", "patient", "with", "systemic", "lupus", "erythematosus", "." ]
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BC5CDR-1242
[ "CONCLUSIONS", ":", "In", "the", "literature", ",", "the", "most", "-", "frequent", "cause", "of", "hemolytic", "uremic", "syndrome", "in", "patients", "following", "renal", "transplantation", "is", "recurrence", "of", "the", "hemolytic", "uremic", "syndrome", "." ]
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BC5CDR-1243
[ "Other", "causes", "include", "drug", "-", "related", "(", "cyclosporine", ",", "tacrolimus", ")", "toxicity", ",", "procoagulant", "status", ",", "and", "antibody", "-", "mediated", "rejection", "." ]
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BC5CDR-1244
[ "We", "found", "that", "the", "most", "-", "frequent", "cause", "of", "thrombotic", "microangiopathy", "was", "drug", "related", ",", "secondary", "mainly", "to", "cyclosporine", "." ]
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BC5CDR-1245
[ "In", "the", "current", "study", ",", "the", "frequency", "of", "thrombotic", "microangiopathy", "was", "similar", "to", "the", "percentage", "reported", "in", "the", "literature", "(", "20", "%", ")", "." ]
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BC5CDR-1246
[ "Comparison", "of", "developmental", "toxicity", "of", "selective", "and", "non", "-", "selective", "cyclooxygenase", "-", "2", "inhibitors", "in", "CRL", ":", "(", "WI", ")", "WUBR", "Wistar", "rats", "-", "-", "DFU", "and", "piroxicam", "study", "." ]
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BC5CDR-1247
[ "BACKGROUND", ":", "Cyclooxygenase", "(", "COX", ")", "inhibitors", "are", "one", "of", "the", "most", "often", "ingested", "drugs", "during", "pregnancy", "." ]
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BC5CDR-1248
[ "Unlike", "general", "toxicity", "data", ",", "their", "prenatal", "toxic", "effects", "were", "not", "extensively", "studied", "before", "." ]
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BC5CDR-1249
[ "The", "hemolytic", "effect", "of", "TAM", "is", "prevented", "by", "low", "concentrations", "of", "alpha", "-", "tocopherol", "(", "alpha", "-", "T", ")", "and", "alpha", "-", "tocopherol", "acetate", "(", "alpha", "-", "TAc", ")", "(", "inactivated", "functional", "hydroxyl", ")", "indicating", "that", "TAM", "-", "induced", "hemolysis", "is", "not", "related", "to", "oxidative", "membrane", "damage", "." ]
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BC5CDR-125
[ "The", "aim", "of", "the", "experiment", "was", "to", "evaluate", "the", "developmental", "toxicity", "of", "the", "non", "-", "selective", "(", "piroxicam", ")", "and", "selective", "(", "DFU", ";", "5", ",", "5", "-", "dimethyl", "-", "3", "-", "(", "3", "-", "fluorophenyl", ")", "-", "4", "-", "(", "4", "-", "methylsulphonyl", ")", "phenyl", "-", "2", "(", "5H", ")", "-", "furanon", ")", "COX", "-", "2", "inhibitors", "." ]
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BC5CDR-1250
[ "METHODS", ":", "Drugs", "were", "separately", ",", "orally", "once", "daily", "dosed", "to", "pregnant", "rats", "from", "day", "8", "to", "21", "(", "GD1", "=", "plug", "day", ")", "." ]
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BC5CDR-1251
[ "Doses", "were", "set", "at", "0", ".", "3", ",", "3", ".", "0", "and", "30", ".", "0mg", "/", "kg", "for", "piroxicam", "and", "0", ".", "2", ",", "2", ".", "0", "and", "20", ".", "0mg", "/", "kg", "for", "DFU", "." ]
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BC5CDR-1252
[ "Fetuses", "were", "delivered", "on", "GD", "21", "and", "routinely", "examined", "." ]
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BC5CDR-1253
[ "Comprehensive", "clinical", "and", "developmental", "measurements", "were", "done", "." ]
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BC5CDR-1254
[ "The", "pooled", "statistical", "analysis", "for", "ventricular", "septal", "(", "VSD", ")", "and", "midline", "(", "MD", ")", "defects", "was", "performed", "for", "rat", "fetuses", "exposed", "to", "piroxicam", ",", "selective", "and", "non", "-", "selective", "COX", "-", "2", "inhibitor", "based", "on", "present", "and", "historic", "data", "." ]
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BC5CDR-1255
[ "RESULTS", ":", "Maternal", "toxicity", ",", "intrauterine", "growth", "retardation", ",", "and", "increase", "of", "external", "and", "skeletal", "variations", "were", "found", "in", "rats", "treated", "with", "the", "highest", "dose", "of", "piroxicam", "." ]
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BC5CDR-1256
[ "Decrease", "of", "fetal", "length", "was", "the", "only", "signs", "of", "the", "DFU", "developmental", "toxicity", "observed", "in", "pups", "exposed", "to", "the", "highest", "compound", "dose", "." ]
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BC5CDR-1257
[ "Lack", "of", "teratogenicity", "was", "found", "in", "piroxicam", "and", "DFU", "-", "exposed", "groups", "." ]
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BC5CDR-1258
[ "Prenatal", "exposure", "to", "non", "-", "selective", "COX", "inhibitors", "increases", "the", "risk", "of", "VSD", "and", "MD", "when", "compared", "to", "historic", "control", "but", "not", "with", "selective", "COX", "-", "2", "inhibitors", "." ]
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BC5CDR-1259
[ "This", "was", "further", "evidenced", "by", "absence", "of", "oxygen", "consumption", "and", "hemoglobin", "oxidation", "both", "determined", "in", "parallel", "with", "TAM", "-", "induced", "hemolysis", "." ]
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BC5CDR-126
[ "CONCLUSION", ":", "Both", "selective", "and", "non", "-", "selective", "COX", "-", "2", "inhibitors", "were", "toxic", "for", "rats", "fetuses", "when", "administered", "in", "the", "highest", "dose", "." ]
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BC5CDR-1260
[ "Unlike", "DFU", ",", "piroxicam", "was", "also", "highly", "toxic", "to", "the", "dams", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
BC5CDR-1261
[ "Prenatal", "exposure", "to", "selective", "COX", "-", "2", "inhibitors", "does", "not", "increase", "the", "risk", "of", "ventricular", "septal", "and", "midline", "defects", "in", "rat", "when", "compared", "to", "non", "-", "selective", "drugs", "and", "historic", "control", "." ]
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BC5CDR-1262
[ "Lone", "atrial", "fibrillation", "associated", "with", "creatine", "monohydrate", "supplementation", "." ]
[ 0, 1, 2, 0, 0, 0, 0, 0, 0 ]
BC5CDR-1263
[ "Atrial", "fibrillation", "in", "young", "patients", "without", "structural", "heart", "disease", "is", "rare", "." ]
[ 1, 2, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0 ]
BC5CDR-1264
[ "Therefore", ",", "when", "the", "arrhythmia", "is", "present", "in", "this", "population", ",", "reversible", "causes", "must", "be", "identified", "and", "resolved", "." ]
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BC5CDR-1265
[ "Thyroid", "disorders", ",", "illicit", "drug", "or", "stimulant", "use", ",", "and", "acute", "alcohol", "intoxication", "are", "among", "these", "causes", "." ]
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BC5CDR-1266
[ "We", "report", "the", "case", "of", "a", "30", "-", "year", "-", "old", "Caucasian", "man", "who", "came", "to", "the", "emergency", "department", "in", "atrial", "fibrillation", "with", "rapid", "ventricular", "response", "." ]
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BC5CDR-1267