Datasets:

huy-nh-2000

/

instructUIE

like 0

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{ "id": "200", "sentence": "Chronic myelogenous leukemia evolves in two clinically distinct stages: a chronic and a blast crisis phase .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "201", "sentence": "The molecular changes associated with chronic phase to blast crisis transition are largely unknown.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "202", "sentence": "We have identified a cDNA clone , DR-nm23 , differentially expressed in a blast-crisis cDNA library, which has approximately 70% sequence similarity to the putative metastatic suppressor genes , nm23-H1 and nm23-H2 .", "label": " ( DNA: putative metastatic suppressor genes, None) , ( protein: DR-nm23, None) , ( DNA: nm23-H2, None) , ( DNA: cDNA clone, None) , ( DNA: blast-crisis cDNA library,, None) , ( DNA: nm23-H1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: putative metastatic suppressor genes, None) , ( protein: DR-nm23, None) , ( DNA: nm23-H2, None) , ( DNA: cDNA clone, None) , ( DNA: blast-crisis cDNA library,, None) , ( DNA: nm23-H1, None) " }

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{ "id": "203", "sentence": "The deduced amino acid sequence similarity to the proteins encoded by these two latter genes is approximately 65% and includes domains and amino acid residues (the leucine zipper-like and the RGD domain , a serine and a histidine residue in the NH2- and in the COOH-terminal portion of the protein, respectively) postulated to be important for nm23 function .", "label": " ( protein: nm23, None) , ( protein: COOH-terminal portion, None) , ( protein: amino acid sequence, None) , ( protein: NH2-, None) , ( protein: leucine zipper-like, None) , ( protein: RGD domain, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nm23, None) , ( protein: COOH-terminal portion, None) , ( protein: amino acid sequence, None) , ( protein: NH2-, None) , ( protein: leucine zipper-like, None) , ( protein: RGD domain, None) " }

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{ "id": "204", "sentence": "DR-nm23 mRNA is preferentially expressed at early stages of myeloid differentiation of highly purified CD34+ cells .", "label": " ( RNA: DR-nm23 mRNA, None) , ( cell line: highly purified CD34+ cells, None) , ( protein: DR-nm23, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: DR-nm23 mRNA, None) , ( cell line: highly purified CD34+ cells, None) , ( protein: DR-nm23, None) " }

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{ "id": "205", "sentence": "Its constitutive expression in the myeloid precursor 32Dc13 cell line , which is growth-factor dependent for both proliferation and differentiation , results in inhibition of granulocytic differentiation induced by granulocyte colony-stimulating factor and causes apoptotic cell death .", "label": " ( cell type: granulocyte, None) , ( cell line: myeloid precursor 32Dc13 cell line, None) , ( protein: granulocyte colony-stimulating factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: granulocyte, None) , ( cell line: myeloid precursor 32Dc13 cell line, None) , ( protein: granulocyte colony-stimulating factor, None) " }

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{ "id": "206", "sentence": "These results are consistent with a role for DR-nm23 in normal hematopoiesis and raise the possibility that its overexpression contributes to differentiation arrest , a feature of blastic transformation in chronic myelogenous leukemia .", "label": " ( protein: DR-nm23, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: DR-nm23, None) " }

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{ "id": "207", "sentence": "An interferon-gamma activation sequence mediates the transcriptional regulation of the IgG Fc receptor type IC gene by interferon-gamma .", "label": " ( DNA: interferon-gamma activation sequence, None) , ( DNA: IgG Fc receptor type IC gene, None) , ( protein: IgG Fc receptor, None) , ( protein: interferon-gamma, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: interferon-gamma activation sequence, None) , ( DNA: IgG Fc receptor type IC gene, None) , ( protein: IgG Fc receptor, None) , ( protein: interferon-gamma, None) " }

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{ "id": "208", "sentence": "Expression of the IgG Fc receptor type I ( Fc gamma RI ) on myeloid cells is dramatically increased by treatment with interferon-gamma ( IFN-gamma ).", "label": " ( protein: IgG Fc receptor type I, None) , ( protein: interferon-gamma, None) , ( protein: Fc gamma RI, None) , ( protein: IgG Fc receptor, None) , ( protein: IFN-gamma, None) , ( cell type: myeloid cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IgG Fc receptor type I, None) , ( protein: interferon-gamma, None) , ( protein: Fc gamma RI, None) , ( protein: IgG Fc receptor, None) , ( protein: IFN-gamma, None) , ( cell type: myeloid cells, None) " }

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{ "id": "209", "sentence": "We observed that Fc gamma RI transcript levels in monoblast-like U937 cells were elevated within 3 hr and peaked 12 hr after exposure to IFN-gamma .", "label": " ( cell line: monoblast-like U937 cells, None) , ( protein: IFN-gamma, None) , ( protein: Fc gamma RI, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: monoblast-like U937 cells, None) , ( protein: IFN-gamma, None) , ( protein: Fc gamma RI, None) " }

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{ "id": "210", "sentence": "Treatment of U937 with IFN-gamma for 9 hr in the presence of cycloheximide led to super-induction of Fc gamma RI expression.", "label": " ( protein: Fc gamma RI, None) , ( protein: IFN-gamma, None) , ( cell line: U937, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Fc gamma RI, None) , ( protein: IFN-gamma, None) , ( cell line: U937, None) " }

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{ "id": "211", "sentence": "Nuclear run-on analysis revealed that the rate of Fc gamma RI transcription was increased by IFN-gamma .", "label": " ( protein: IFN-gamma, None) , ( protein: Fc gamma RI, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IFN-gamma, None) , ( protein: Fc gamma RI, None) " }

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{ "id": "212", "sentence": "Genomic sequence upstream of the Fc gamma RIC gene was cloned and subjected to primer extension analysis , which demonstrated a single transcription initiation site without a TATA box .", "label": " ( DNA: Fc gamma RIC gene, None) , ( DNA: transcription initiation site, None) , ( DNA: TATA box, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Fc gamma RIC gene, None) , ( DNA: transcription initiation site, None) , ( DNA: TATA box, None) " }

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{ "id": "213", "sentence": "Transient transfections of CAT reporter gene constructs containing various Fc gamma RIC promoter sequences into U937 cells revealed that a 20-bp region surrounding the transcription start site (-7 to +13) was capable of mediating transcription initiation and that an IFN-gamma responsive element ( GIRE ) was present within 74 bp upstream of the transcription initiation site .", "label": " ( DNA: CAT reporter gene constructs, None) , ( DNA: 20-bp region, None) , ( DNA: transcription start site, None) , ( DNA: reporter gene constructs, None) , ( cell line: U937 cells, None) , ( DNA: Fc gamma RIC promoter sequences, None) , ( DNA: IFN-gamma responsive element, None) , ( DNA: 74 bp upstream, None) , ( DNA: GIRE, None) , ( DNA: transcription initiation site, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: CAT reporter gene constructs, None) , ( DNA: 20-bp region, None) , ( DNA: transcription start site, None) , ( DNA: reporter gene constructs, None) , ( cell line: U937 cells, None) , ( DNA: Fc gamma RIC promoter sequences, None) , ( DNA: IFN-gamma responsive element, None) , ( DNA: 74 bp upstream, None) , ( DNA: GIRE, None) , ( DNA: transcription initiation site, None) " }

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{ "id": "214", "sentence": "A 17-bp sequence between positions -51 and -35 conferred IFN-gamma responsiveness on a heterologous promoter .", "label": " ( DNA: 17-bp sequence, None) , ( protein: IFN-gamma, None) , ( DNA: heterologous promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: 17-bp sequence, None) , ( protein: IFN-gamma, None) , ( DNA: heterologous promoter, None) " }

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{ "id": "215", "sentence": "Double-stranded GIRE sequence , but not a scrambled sequence , was specifically bound by nuclear proteins from IFN-gamma treated U937 cells .", "label": " ( protein: nuclear proteins, None) , ( DNA: Double-stranded GIRE sequence, None) , ( DNA: scrambled sequence, None) , ( cell line: IFN-gamma treated U937 cells, None) , ( protein: IFN-gamma, None) , ( cell line: U937 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear proteins, None) , ( DNA: Double-stranded GIRE sequence, None) , ( DNA: scrambled sequence, None) , ( cell line: IFN-gamma treated U937 cells, None) , ( protein: IFN-gamma, None) , ( cell line: U937 cells, None) " }

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{ "id": "216", "sentence": "Gel shift experiments further showed that the STAT1 alpha protein bound to the Fc gamma RIC GIRE in response to IFN-gamma treatment of U937 cells .", "label": " ( protein: STAT1 alpha protein, None) , ( DNA: Fc gamma RIC GIRE, None) , ( cell line: U937 cells, None) , ( protein: IFN-gamma, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: STAT1 alpha protein, None) , ( DNA: Fc gamma RIC GIRE, None) , ( cell line: U937 cells, None) , ( protein: IFN-gamma, None) " }

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{ "id": "217", "sentence": "The Fc gamma RIC GIRE is homologous to the IFN-gamma activation sequence ( GAS ) of the guanylate binding protein and to X box elements of class II MHC genes .", "label": " ( DNA: Fc gamma RIC GIRE, None) , ( protein: guanylate binding protein, None) , ( DNA: IFN-gamma activation sequence, None) , ( DNA: class II MHC genes, None) , ( DNA: GAS, None) , ( DNA: X box elements, None) , ( protein: IFN-gamma, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Fc gamma RIC GIRE, None) , ( protein: guanylate binding protein, None) , ( DNA: IFN-gamma activation sequence, None) , ( DNA: class II MHC genes, None) , ( DNA: GAS, None) , ( DNA: X box elements, None) , ( protein: IFN-gamma, None) " }

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{ "id": "218", "sentence": "Our results demonstrate that transcriptional regulation of the Fc gamma RIC gene by IFN-gamma involves the binding of STAT1 alpha to a 17-bp GAS homology in the proximal promoter .", "label": " ( protein: IFN-gamma, None) , ( DNA: Fc gamma RIC gene, None) , ( DNA: 17-bp GAS homology, None) , ( DNA: proximal promoter, None) , ( protein: STAT1 alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IFN-gamma, None) , ( DNA: Fc gamma RIC gene, None) , ( DNA: 17-bp GAS homology, None) , ( DNA: proximal promoter, None) , ( protein: STAT1 alpha, None) " }

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{ "id": "219", "sentence": "Constitutively activated Jak -STAT pathway in T cells transformed with HTLV-I .", "label": " ( protein: Jak, None) , ( cell type: T cells, None) , ( protein: -STAT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Jak, None) , ( cell type: T cells, None) , ( protein: -STAT, None) " }

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{ "id": "220", "sentence": "Human T cell lymphotropic virus I ( HTLV-I ) is the etiological agent for adult T cell leukemia and tropical spastic paraparesis (also termed HTLV-I -associated myelopathy ).", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "221", "sentence": "HTLV-I -infected peripheral blood T cells exhibit an initial phase of interleukin-2 ( IL-2 )-dependent growth ; over time, by an unknown mechanism, the cells become IL-2 -independent .", "label": " ( cell type: HTLV-I -infected peripheral blood T cells, None) , ( protein: interleukin-2, None) , ( protein: IL-2, None) , ( cell type: T cells, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: HTLV-I -infected peripheral blood T cells, None) , ( protein: interleukin-2, None) , ( protein: IL-2, None) , ( cell type: T cells, None) , ( protein: IL-2, None) " }

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{ "id": "222", "sentence": "Whereas the Jak kinases Jak1 and Jak3 and the signal transducer and activator of transcription proteins Stat3 and Stat5 are activated in normal T cells in response to IL-2 , this signaling pathway was constitutively activated in HTLV-I -transformed cells .", "label": " ( cell type: T cells, None) , ( protein: Stat5, None) , ( protein: Stat3, None) , ( protein: Jak3, None) , ( cell line: HTLV-I -transformed cells, None) , ( cell type: normal T cells, None) , ( protein: transcription proteins, None) , ( protein: Jak1, None) , ( protein: Jak kinases, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: Stat5, None) , ( protein: Stat3, None) , ( protein: Jak3, None) , ( cell line: HTLV-I -transformed cells, None) , ( cell type: normal T cells, None) , ( protein: transcription proteins, None) , ( protein: Jak1, None) , ( protein: Jak kinases, None) , ( protein: IL-2, None) " }

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{ "id": "223", "sentence": "In HTLV-I -infected cord blood lymphocytes , the transition from IL-2 -dependent to IL-2 -independent growth correlated with the acquisition of a constitutively activated Jak -STAT pathway , which suggests that this pathway participates in HTLV-I -mediated T cell transformation .", "label": " ( protein: Jak, None) , ( protein: -STAT, None) , ( protein: IL-2, None) , ( protein: IL-2, None) , ( cell line: HTLV-I -infected cord blood lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Jak, None) , ( protein: -STAT, None) , ( protein: IL-2, None) , ( protein: IL-2, None) , ( cell line: HTLV-I -infected cord blood lymphocytes, None) " }

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{ "id": "224", "sentence": "Nitric oxide decreases cytokine -induced endothelial activation .", "label": " ( protein: cytokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokine, None) " }

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{ "id": "225", "sentence": "Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines .", "label": " ( protein: proinflammatory cytokines, None) , ( protein: adhesion molecules, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: proinflammatory cytokines, None) , ( protein: adhesion molecules, None) " }

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{ "id": "226", "sentence": "To test the hypothesis that nitric oxide ( NO ) limits endothelial activation , we treated cytokine-stimulated human saphenous vein endothelial cells with several NO donors and assessed their effects on the inducible expression of vascular cell adhesion molecule-1 ( VCAM-1 ).", "label": " ( cell line: cytokine-stimulated human saphenous vein endothelial cells, None) , ( protein: VCAM-1, None) , ( protein: vascular cell adhesion molecule-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: cytokine-stimulated human saphenous vein endothelial cells, None) , ( protein: VCAM-1, None) , ( protein: vascular cell adhesion molecule-1, None) " }

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{ "id": "227", "sentence": "In a concentration-dependent manner , NO inhibited interleukin (IL)-1 alpha-stimulated VCAM-1 expression by 35-55% as determined by cell surface enzyme immunoassays and flow cytometry .", "label": " ( protein: interleukin (IL)-1, None) , ( protein: VCAM-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: interleukin (IL)-1, None) , ( protein: VCAM-1, None) " }

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{ "id": "228", "sentence": "This inhibition was paralleled by reduced monocyte adhesion to endothelial monolayers in nonstatic assays , was unaffected by cGMP analogues , and was quantitatively similar after stimulation by either IL-1 alpha , IL-1 beta , IL-4 , tumor necrosis factor ( TNF alpha ), or bacterial lipopolysaccharide .", "label": " ( protein: TNF alpha, None) , ( protein: IL-1 beta, None) , ( protein: IL-4, None) , ( protein: IL-1 alpha, None) , ( protein: tumor necrosis factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TNF alpha, None) , ( protein: IL-1 beta, None) , ( protein: IL-4, None) , ( protein: IL-1 alpha, None) , ( protein: tumor necrosis factor, None) " }

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{ "id": "229", "sentence": "NO also decreased the endothelial expression of other leukocyte adhesion molecules ( E-selectin and to a lesser extent, intercellular adhesion molecule-1 ) and secretable cytokines ( IL-6 and IL-8 ).", "label": " ( protein: cytokines, None) , ( protein: E-selectin, None) , ( protein: IL-8, None) , ( protein: leukocyte adhesion molecules, None) , ( protein: intercellular adhesion molecule-1, None) , ( protein: adhesion molecules, None) , ( protein: IL-6, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokines, None) , ( protein: E-selectin, None) , ( protein: IL-8, None) , ( protein: leukocyte adhesion molecules, None) , ( protein: intercellular adhesion molecule-1, None) , ( protein: adhesion molecules, None) , ( protein: IL-6, None) " }

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{ "id": "230", "sentence": "Inhibition of endogenous NO production by L-N-monomethyl-arginine also induced the expression of VCAM-1 , but did not augment cytokine-induced VCAM-1 expression .", "label": " ( protein: VCAM-1, None) , ( protein: VCAM-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: VCAM-1, None) , ( protein: VCAM-1, None) " }

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{ "id": "231", "sentence": "Nuclear run-on assays , transfection studies using various VCAM-1 promoter reporter gene constructs , and electrophoretic mobility shift assays indicated that NO represses VCAM-1 gene transcription , in part, by inhibiting NF-kappa B .", "label": " ( protein: VCAM-1, None) , ( DNA: VCAM-1 promoter reporter gene constructs, None) , ( protein: VCAM-1, None) , ( protein: NF-kappa B, None) , ( DNA: reporter gene constructs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: VCAM-1, None) , ( DNA: VCAM-1 promoter reporter gene constructs, None) , ( protein: VCAM-1, None) , ( protein: NF-kappa B, None) , ( DNA: reporter gene constructs, None) " }

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{ "id": "232", "sentence": "We propose that NO 's ability to limit endothelial activation and inhibit monocyte adhesion may contribute to some of its antiatherogenic and antiinflammatory properties within the vessel wall .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "233", "sentence": "MIP1 alpha nuclear protein ( MNP ), a novel transcription factor expressed in hematopoietic cells that is crucial for transcription of the human MIP-1 alpha gene .", "label": " ( protein: MIP1 alpha nuclear protein, None) , ( protein: MNP, None) , ( protein: transcription factor, None) , ( DNA: human MIP-1 alpha gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: MIP1 alpha nuclear protein, None) , ( protein: MNP, None) , ( protein: transcription factor, None) , ( DNA: human MIP-1 alpha gene, None) " }

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{ "id": "234", "sentence": "Murine macrophage inflammatory protein 1 alpha ( MIP-1 alpha ) and its human equivalent ( GOS19 , LD78 , or AT464 ) are members of the -C-C family of low-molecular-weight chemokines .", "label": " ( protein: LD78, None) , ( protein: MIP-1 alpha, None) , ( protein: low-molecular-weight chemokines, None) , ( protein: human equivalent, None) , ( protein: Murine macrophage inflammatory protein 1 alpha, None) , ( protein: GOS19, None) , ( protein: -C-C family, None) , ( protein: AT464, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LD78, None) , ( protein: MIP-1 alpha, None) , ( protein: low-molecular-weight chemokines, None) , ( protein: human equivalent, None) , ( protein: Murine macrophage inflammatory protein 1 alpha, None) , ( protein: GOS19, None) , ( protein: -C-C family, None) , ( protein: AT464, None) " }

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{ "id": "235", "sentence": "Secreted from activated T cells and macrophages , bone marrow-derived MIP-1 alpha /GOS19 inhibits primitive hematopoietic stem cells and appears to be involved in the homeostatic control of stem cell proliferation .", "label": " ( protein: marrow-derived MIP-1 alpha /GOS19, None) , ( protein: MIP-1 alpha, None) , ( protein: /GOS19, None) , ( cell type: macrophages, None) , ( cell type: T cells, None) , ( cell type: stem cell, None) , ( cell type: activated T cells, None) , ( cell type: primitive hematopoietic stem cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: marrow-derived MIP-1 alpha /GOS19, None) , ( protein: MIP-1 alpha, None) , ( protein: /GOS19, None) , ( cell type: macrophages, None) , ( cell type: T cells, None) , ( cell type: stem cell, None) , ( cell type: activated T cells, None) , ( cell type: primitive hematopoietic stem cells, None) " }

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{ "id": "236", "sentence": "It also induces chemotaxis and inflammatory responses in mature cell types .", "label": " ( cell type: mature cell types, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: mature cell types, None) " }

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{ "id": "237", "sentence": "Therefore, it is important to understand the mechanisms which control the expression of MIP-1 alpha /GOS19 .", "label": " ( protein: MIP-1 alpha, None) , ( protein: /GOS19, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: MIP-1 alpha, None) , ( protein: /GOS19, None) " }

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{ "id": "238", "sentence": "Previous work has shown that in Jurkat T cells , a set of widely expressed transcription factors (the ICK-1 family ) affect the GOS19 promoter .", "label": " ( protein: ICK-1 family, None) , ( cell line: Jurkat T cells, None) , ( cell type: T cells, None) , ( DNA: GOS19 promoter, None) , ( protein: GOS19, None) , ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ICK-1 family, None) , ( cell line: Jurkat T cells, None) , ( cell type: T cells, None) , ( DNA: GOS19 promoter, None) , ( protein: GOS19, None) , ( protein: transcription factors, None) " }

[]

{ "id": "239", "sentence": "One member, ICK-1A , behaves as a strong negative regulator .", "label": " ( protein: strong negative regulator, None) , ( protein: ICK-1A, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: strong negative regulator, None) , ( protein: ICK-1A, None) " }

[]

{ "id": "240", "sentence": "In this communication, we provide evidence that the pathway of induction in the macrophage cell line U937 is different from that in Jurkat cells .", "label": " ( cell line: Jurkat cells, None) , ( cell line: macrophage cell line, None) , ( cell line: U937, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Jurkat cells, None) , ( cell line: macrophage cell line, None) , ( cell line: U937, None) " }

[]

{ "id": "241", "sentence": "Furthermore, we show that the ICK-1 binding site does not confer negative regulation in U937 cells .", "label": " ( cell line: U937 cells, None) , ( DNA: ICK-1 binding site, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: U937 cells, None) , ( DNA: ICK-1 binding site, None) " }

[]

{ "id": "242", "sentence": "We provide evidence for an additional binding site , the MIP-1 alpha nuclear protein (MNP) site , which overlaps the ICK-1 site .", "label": " ( DNA: ICK-1 site, None) , ( protein: MIP-1 alpha, None) , ( DNA: binding site, None) , ( DNA: MIP-1 alpha nuclear protein (MNP) site, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: ICK-1 site, None) , ( protein: MIP-1 alpha, None) , ( DNA: binding site, None) , ( DNA: MIP-1 alpha nuclear protein (MNP) site, None) " }

[]

{ "id": "243", "sentence": "Interaction of nuclear extracts from various cell lines and tissue with the MNP site leads to the formation of fast-migrating protein-DNA complexes with similar but distinct electrophoretic mobilities .", "label": " ( protein: fast-migrating protein-DNA complexes, None) , ( DNA: MNP site, None) , ( cell line: various cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: fast-migrating protein-DNA complexes, None) , ( DNA: MNP site, None) , ( cell line: various cell lines, None) " }

[]

{ "id": "244", "sentence": "A mutation of the MNP site which does not abrogate ICK-1 binding inactivates the GOS19.1 promoter in U937 cells and reduces its activity by fourfold in Jurkat cells .", "label": " ( cell line: Jurkat cells, None) , ( DNA: MNP site, None) , ( cell line: U937 cells, None) , ( DNA: GOS19.1 promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Jurkat cells, None) , ( DNA: MNP site, None) , ( cell line: U937 cells, None) , ( DNA: GOS19.1 promoter, None) " }

[]

{ "id": "245", "sentence": "We propose that the MNP protein (s) binding at the MNP site constitutes a novel transcription factor (s) expressed in hematopoietic cells .", "label": " ( DNA: MNP site, None) , ( protein: MNP protein, None) , ( protein: transcription factor, None) , ( cell type: hematopoietic cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: MNP site, None) , ( protein: MNP protein, None) , ( protein: transcription factor, None) , ( cell type: hematopoietic cells, None) " }

[]

{ "id": "246", "sentence": "The effect of Toremifene on the expression of some genes in human mononuclear cells .", "label": " ( cell type: human mononuclear cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human mononuclear cells, None) " }

[]

{ "id": "247", "sentence": "Toremifene exerts multiple and varied effects on the gene expression of human peripheral mononuclear cells .", "label": " ( cell type: human peripheral mononuclear cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human peripheral mononuclear cells, None) " }

[]

{ "id": "248", "sentence": "After short-term, in vitro exposure to therapeutical levels , distinct changes in P-glycoprotein , steroid receptors , p53 and Bcl-2 expression take place.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "249", "sentence": "In view of the increasing use of antiestrogens in cancer therapy and prevention , there is obvious merit in long-term in vivo studies to be conducted.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "250", "sentence": "The interleukin-5 /receptor interaction activates Lyn and Jak2 tyrosine kinases and propagates signals via the Ras-Raf-1-MAP kinase and the Jak -STAT pathways in eosinophils .", "label": " ( protein: Jak, None) , ( protein: -STAT, None) , ( protein: interleukin-5, None) , ( cell type: eosinophils, None) , ( protein: Ras-Raf-1-MAP kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Jak, None) , ( protein: -STAT, None) , ( protein: interleukin-5, None) , ( cell type: eosinophils, None) , ( protein: Ras-Raf-1-MAP kinase, None) " }

[]

{ "id": "251", "sentence": "We have shown that the interaction of interleukin (IL)-5 with the receptor activates Lyn tyrosine kinase within 1 min and Jak2 tyrosine kinase within 1-3 min.", "label": " ( protein: interleukin (IL)-5, None) , ( protein: Lyn tyrosine kinase, None) , ( protein: Jak2 tyrosine kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: interleukin (IL)-5, None) , ( protein: Lyn tyrosine kinase, None) , ( protein: Jak2 tyrosine kinase, None) " }

[]

{ "id": "252", "sentence": "IL-5 also stimulates GTP binding to p21ras .", "label": " ( protein: p21ras, None) , ( protein: IL-5, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p21ras, None) , ( protein: IL-5, None) " }

[]

{ "id": "253", "sentence": "The signal is subsequently propagated through the activation of Raf-1 , MEK , and MAP kinases as shown by their increased autophosphorylation in vitro and phosphorylation in situ.", "label": " ( protein: MEK, None) , ( protein: Raf-1, None) , ( protein: MAP kinases, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: MEK, None) , ( protein: Raf-1, None) , ( protein: MAP kinases, None) " }

[]

{ "id": "254", "sentence": "Jak2 kinase has been shown to phosphorylate STAT nuclear proteins .", "label": " ( protein: nuclear proteins, None) , ( protein: Jak2 kinase, None) , ( protein: STAT nuclear proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear proteins, None) , ( protein: Jak2 kinase, None) , ( protein: STAT nuclear proteins, None) " }

[]

{ "id": "255", "sentence": "The activation of STAT nuclear factors was studied by electrophoretic mobility shift assay using a gamma activation site ( GAS ) probe .", "label": " ( DNA: gamma activation site, None) , ( protein: STAT nuclear factors, None) , ( DNA: GAS, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: gamma activation site, None) , ( protein: STAT nuclear factors, None) , ( DNA: GAS, None) " }

[]

{ "id": "256", "sentence": "We found that IL-5 induces two GAS-binding proteins in eosinophils , one of which is STAT1 .", "label": " ( protein: IL-5, None) , ( protein: GAS-binding proteins, None) , ( cell type: eosinophils, None) , ( protein: STAT1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-5, None) , ( protein: GAS-binding proteins, None) , ( cell type: eosinophils, None) , ( protein: STAT1, None) " }

[]

{ "id": "257", "sentence": "We conclude that IL-5 induced signals are propagated through two distinct pathways: (1) Lyn --> Ras --> Raf-1 --> MEK --> MAP kinase and (2) Jak2 --> STAT1 .", "label": " ( protein: Lyn, None) , ( protein: Jak2, None) , ( protein: STAT1, None) , ( protein: MAP kinase, None) , ( protein: Ras, None) , ( protein: MEK, None) , ( protein: Raf-1, None) , ( protein: IL-5, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Lyn, None) , ( protein: Jak2, None) , ( protein: STAT1, None) , ( protein: MAP kinase, None) , ( protein: Ras, None) , ( protein: MEK, None) , ( protein: Raf-1, None) , ( protein: IL-5, None) " }

[]

{ "id": "258", "sentence": "The retinoblastoma gene product negatively regulates transcriptional activation mediated by the human cytomegalovirus IE2 protein .", "label": " ( protein: transcriptional activation, None) , ( protein: retinoblastoma gene product, None) , ( protein: human cytomegalovirus IE2 protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcriptional activation, None) , ( protein: retinoblastoma gene product, None) , ( protein: human cytomegalovirus IE2 protein, None) " }

[]

{ "id": "259", "sentence": "The IE2 gene product of human cytomegalovirus ( HCMV ) is one of a few viral regulatory proteins expressed immediately upon infection of the host cell .", "label": " ( protein: IE2 gene product, None) , ( cell type: host cell, None) , ( protein: viral regulatory proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IE2 gene product, None) , ( cell type: host cell, None) , ( protein: viral regulatory proteins, None) " }

[]

{ "id": "260", "sentence": "It is a potent transcriptional activator of many viral and cellular promoters .", "label": " ( protein: transcriptional activator, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcriptional activator, None) " }

[]

{ "id": "261", "sentence": "We found that the retinoblastoma susceptibility gene product ( Rb ) dramatically suppressed this IE2 transactivation of various promoters .", "label": " ( DNA: various promoters, None) , ( protein: retinoblastoma susceptibility gene product, None) , ( protein: IE2, None) , ( protein: Rb, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: various promoters, None) , ( protein: retinoblastoma susceptibility gene product, None) , ( protein: IE2, None) , ( protein: Rb, None) " }

[]

{ "id": "262", "sentence": "However, unlike another tumor suppressor protein , p53 , Rb did not have any significant effect on basal levels of transcription , suggesting that Rb specifically interacts with IE2 rather than other cellular factors involved in the general transcription machinery .", "label": " ( protein: p53, None) , ( protein: Rb, None) , ( protein: Rb, None) , ( protein: cellular factors, None) , ( protein: IE2, None) , ( protein: tumor suppressor protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p53, None) , ( protein: Rb, None) , ( protein: Rb, None) , ( protein: cellular factors, None) , ( protein: IE2, None) , ( protein: tumor suppressor protein, None) " }

[]

{ "id": "263", "sentence": "We found by protein-affinity chromatography that Rb in nuclear extracts or produced by in vitro translation directly bound to IE2 .", "label": " ( protein: Rb, None) , ( protein: IE2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Rb, None) , ( protein: IE2, None) " }

[]

{ "id": "264", "sentence": "Our results suggest that Rb may regulate the life cycle of HCMV , which is endemic in the human population .", "label": " ( protein: Rb, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Rb, None) " }

[]

{ "id": "265", "sentence": "Furthermore, these data may provide new insights into the slow rate of HCMV DNA replication in cells and the possible involvement of HCMV in tumorigenesis .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "266", "sentence": "Expression of the nucleoside diphosphate kinase in human skin cancers : an immunohistochemical study .", "label": " ( protein: nucleoside diphosphate kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nucleoside diphosphate kinase, None) " }

[]

{ "id": "267", "sentence": "Expression of nucleoside diphosphate(NDP) kinase , which is homologous to the nm23 gene product in a variety of species, has been found to be inversely associated with metastatic potential .", "label": " ( protein: nucleoside diphosphate(NDP) kinase, None) , ( DNA: nm23 gene, None) , ( protein: nm23 gene product, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nucleoside diphosphate(NDP) kinase, None) , ( DNA: nm23 gene, None) , ( protein: nm23 gene product, None) " }

[]

{ "id": "268", "sentence": "However, the relationship remains controversial according to the tumor cell types and experimental system , with conflicting results from different research groups.", "label": " ( cell type: tumor cell types, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: tumor cell types, None) " }

[]

{ "id": "269", "sentence": "In order to determine whether NDP kinase expression serves as a marker for metastatic potential in human skin cancer , we assessed the levels of NDP kinase expression in 9 keratoacanthomas ( KAs ), 26 squamous cell carcinomas ( SCCs ), and 25 basal cell carcinomas ( BCCs ) using immunohistochemistry .", "label": " ( protein: NDP kinase, None) , ( protein: NDP kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NDP kinase, None) , ( protein: NDP kinase, None) " }

[]

{ "id": "270", "sentence": "The expression of NDP kinase was intense in KA and SCC compared with BCC .", "label": " ( protein: NDP kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NDP kinase, None) " }

[]

{ "id": "271", "sentence": "However, the difference of NDP kinase expression between KA and SCC was not statistically significant.", "label": " ( protein: NDP kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NDP kinase, None) " }

[]

{ "id": "272", "sentence": "And there was no statistically significant difference in NDP kinase expression between SCC with metastasis and SCC without metastasis .", "label": " ( protein: NDP kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NDP kinase, None) " }

[]

{ "id": "273", "sentence": "Our results contradict the hypothesis concerning the possible role of nm23 gene as a metastatic suppressor gene in human skin cancer .", "label": " ( DNA: nm23 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: nm23 gene, None) " }

[]

{ "id": "274", "sentence": "The mechanism of overexpression in various tumor cell types and its biological significance in cutaneous carcinogenesis remain to be determined.", "label": " ( cell type: tumor cell types, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: tumor cell types, None) " }

[]

{ "id": "275", "sentence": "RB and a novel E2F-1 binding protein in MHC class II deficient B-cell lines and normal IFN-gamma induction of the class IL transactivator CIITA in class II non-inducible RB -defective tumor lines .", "label": " ( protein: IFN-gamma, None) , ( cell line: MHC class II deficient B-cell lines, None) , ( cell line: class II non-inducible RB -defective tumor lines, None) , ( DNA: class IL transactivator, None) , ( protein: RB, None) , ( protein: E2F-1 binding protein, None) , ( protein: RB, None) , ( DNA: CIITA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IFN-gamma, None) , ( cell line: MHC class II deficient B-cell lines, None) , ( cell line: class II non-inducible RB -defective tumor lines, None) , ( DNA: class IL transactivator, None) , ( protein: RB, None) , ( protein: E2F-1 binding protein, None) , ( protein: RB, None) , ( DNA: CIITA, None) " }

[]

{ "id": "276", "sentence": "The major histocompatibility (MHC) class II genes encode cell surface proteins that bind antigenic peptide for presentation to T-cells .", "label": " ( cell type: T-cells, None) , ( DNA: major histocompatibility (MHC) class II genes, None) , ( protein: cell surface proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T-cells, None) , ( DNA: major histocompatibility (MHC) class II genes, None) , ( protein: cell surface proteins, None) " }

[]

{ "id": "277", "sentence": "The class II proteins are expressed constitutively on B-cells and EBV-transformed B-cells , and are inducible by IFN-gamma on a wide variety of cell types .", "label": " ( cell type: B-cells, None) , ( cell type: B-cells, None) , ( cell type: cell types, None) , ( protein: IFN-gamma, None) , ( protein: class II proteins, None) , ( cell line: EBV-transformed B-cells ,, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: B-cells, None) , ( cell type: B-cells, None) , ( cell type: cell types, None) , ( protein: IFN-gamma, None) , ( protein: class II proteins, None) , ( cell line: EBV-transformed B-cells ,, None) " }

[]

{ "id": "278", "sentence": "Retinoblastoma protein ( RB ) is a tumor suppressor and functions as a transcriptional repressor by binding and inactivating the transactivator E2F-I .", "label": " ( protein: transcriptional repressor, None) , ( DNA: transactivator E2F-I, None) , ( protein: RB, None) , ( protein: Retinoblastoma protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcriptional repressor, None) , ( DNA: transactivator E2F-I, None) , ( protein: RB, None) , ( protein: Retinoblastoma protein, None) " }

[]

{ "id": "279", "sentence": "RB -defective tumor lines are non-inducible for MHC class II by IFN-gamma , or very weakly inducible, but transfection of 2 different lines with RB expression vectors re-establishes or substantially enhances class II inducibility .", "label": " ( DNA: RB expression vectors, None) , ( protein: RB, None) , ( protein: IFN-gamma, None) , ( cell line: RB -defective tumor lines, None) , ( protein: RB, None) , ( protein: MHC class II, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: RB expression vectors, None) , ( protein: RB, None) , ( protein: IFN-gamma, None) , ( cell line: RB -defective tumor lines, None) , ( protein: RB, None) , ( protein: MHC class II, None) " }

[]

{ "id": "280", "sentence": "Therefore, we examined the RB status of a series of B-cell mutants that are defective in class II expression, generated either in vitro or derived from Bare Lymphocyte Syndrome (BLS) patients.", "label": " ( protein: RB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RB, None) " }

[]

{ "id": "281", "sentence": "Nuclear matrix-bound RB was detectable in all cases, indicating that loss of RB is not responsible for decreased class II expression in these lines.", "label": " ( protein: RB, None) , ( protein: RB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RB, None) , ( protein: RB, None) " }

[]

{ "id": "282", "sentence": "A second E2F-I binding protein, most likely DP-I, was also apparently normal in both class II-positive and -negative B-cell lines.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "283", "sentence": "We also examined the IFN-gamma induction of CIITA in RB -defective lines.", "label": " ( protein: RB, None) , ( protein: IFN-gamma, None) , ( DNA: CIITA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RB, None) , ( protein: IFN-gamma, None) , ( DNA: CIITA, None) " }

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{ "id": "284", "sentence": "CIITA is a class II gene transactivator known to be defective in one form of BLS and to be required for the induction of MHC class II by IFN-gamma .", "label": " ( DNA: CIITA, None) , ( protein: MHC class II, None) , ( DNA: class II gene transactivator, None) , ( protein: IFN-gamma, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: CIITA, None) , ( protein: MHC class II, None) , ( DNA: class II gene transactivator, None) , ( protein: IFN-gamma, None) " }

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{ "id": "285", "sentence": "CIITA mRNA is normally inducible by IFN-gamma in class II non-inducible, RB -defective lines , and in one line, re-expression of RB has no effect on CIITA mRNA induction levels .", "label": " ( protein: RB, None) , ( protein: IFN-gamma, None) , ( protein: RB, None) , ( cell line: class II non-inducible, RB -defective lines, None) , ( RNA: CIITA mRNA, None) , ( RNA: CIITA mRNA, None) , ( DNA: CIITA, None) , ( DNA: CIITA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RB, None) , ( protein: IFN-gamma, None) , ( protein: RB, None) , ( cell line: class II non-inducible, RB -defective lines, None) , ( RNA: CIITA mRNA, None) , ( RNA: CIITA mRNA, None) , ( DNA: CIITA, None) , ( DNA: CIITA, None) " }

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{ "id": "286", "sentence": "Thus, the block in MHC class II inducibility in RB -defective cells is not due to a block in CIITA inducibility .", "label": " ( protein: RB, None) , ( DNA: CIITA, None) , ( cell line: RB -defective cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RB, None) , ( DNA: CIITA, None) , ( cell line: RB -defective cells, None) " }

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{ "id": "287", "sentence": "Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes .", "label": " ( cell type: human lymphocytes, None) , ( protein: Interleukin 12, None) , ( protein: STAT4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human lymphocytes, None) , ( protein: Interleukin 12, None) , ( protein: STAT4, None) " }

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{ "id": "288", "sentence": "Interleukin 12 ( IL-12 ) is an important immunoregulatory cytokine whose receptor is a member of the hematopoietin receptor superfamily .", "label": " ( protein: IL-12, None) , ( protein: hematopoietin receptor superfamily, None) , ( protein: Interleukin 12, None) , ( protein: immunoregulatory cytokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-12, None) , ( protein: hematopoietin receptor superfamily, None) , ( protein: Interleukin 12, None) , ( protein: immunoregulatory cytokine, None) " }

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{ "id": "289", "sentence": "We have recently demonstrated that stimulation of human T and natural killer cells with IL-12 induces tyrosine phosphorylation of the Janus family tyrosine kinase JAK2 and Tyk2 , implicating these kinases in the immediate biochemical response to IL-12 .", "label": " ( protein: JAK2, None) , ( protein: IL-12, None) , ( protein: IL-12, None) , ( protein: Tyk2, None) , ( protein: kinases, None) , ( protein: Janus family tyrosine kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: JAK2, None) , ( protein: IL-12, None) , ( protein: IL-12, None) , ( protein: Tyk2, None) , ( protein: kinases, None) , ( protein: Janus family tyrosine kinase, None) " }

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{ "id": "290", "sentence": "Recently, transcription factors known as STATs ( signal transducers and activators of transcription ) have been shown to be tyrosine phosphorylated and activated in response to a number of cytokines that bind hematopoietin receptors and activate JAK kinases .", "label": " ( protein: signal transducers and activators of transcription, None) , ( protein: transcription factors, None) , ( protein: STATs, None) , ( protein: cytokines, None) , ( protein: hematopoietin receptors, None) , ( protein: JAK kinases, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: signal transducers and activators of transcription, None) , ( protein: transcription factors, None) , ( protein: STATs, None) , ( protein: cytokines, None) , ( protein: hematopoietin receptors, None) , ( protein: JAK kinases, None) " }

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{ "id": "291", "sentence": "In this report we demonstrate that IL-12 induces tyrosine phosphorylation of a recently identified STAT family member , STAT4 , and show that STAT4 expression is regulated by T-cell activation .", "label": " ( protein: STAT family member, None) , ( protein: STAT4, None) , ( protein: STAT4, None) , ( protein: IL-12, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: STAT family member, None) , ( protein: STAT4, None) , ( protein: STAT4, None) , ( protein: IL-12, None) " }

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{ "id": "292", "sentence": "Furthermore, we show that IL-12 stimulates formation of a DNA-binding complex that recognizes a DNA sequence previously shown to bind STAT proteins and that this complex contains STAT4 .", "label": " ( protein: IL-12, None) , ( protein: STAT proteins, None) , ( protein: STAT4, None) , ( protein: DNA-binding complex, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-12, None) , ( protein: STAT proteins, None) , ( protein: STAT4, None) , ( protein: DNA-binding complex, None) " }

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{ "id": "293", "sentence": "These data, and the recent demonstration of JAK phosphorylation by IL-12 , identify a rapid signal-transduction pathway likely to mediate IL-12 -induced gene expression .", "label": " ( protein: IL-12, None) , ( protein: JAK, None) , ( protein: IL-12, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-12, None) , ( protein: JAK, None) , ( protein: IL-12, None) " }

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{ "id": "294", "sentence": "Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock .", "label": " ( protein: glucocorticoid receptor, None) , ( cell type: peripheral blood mononuclear leucocyte, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: glucocorticoid receptor, None) , ( cell type: peripheral blood mononuclear leucocyte, None) " }

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{ "id": "295", "sentence": "OBJECTIVE: Activation of the hypothalamic-pituitary-adrenal axis is of vital importance during critical illness.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "296", "sentence": "We have studied the adaptive mechanisms which occur at the level of the glucocorticoid receptor in glucocorticoid target tissues in patients with sepsis or septic shock .", "label": " ( protein: glucocorticoid receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: glucocorticoid receptor, None) " }

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{ "id": "297", "sentence": "DESIGN: The effects of hypercortisolaemia , hyperthermia and cellular composition on number of glucocorticoid receptors per cell and their affinity were evaluated, both in vitro and in vivo, in peripheral blood mononuclear leucocytes of control subjects and in patients with sepsis or septic shock .", "label": " ( cell type: peripheral blood mononuclear leucocytes, None) , ( protein: glucocorticoid receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: peripheral blood mononuclear leucocytes, None) , ( protein: glucocorticoid receptors, None) " }

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{ "id": "298", "sentence": "SUBJECTS: Fifteen patients (age 25-79) with sepsis or septic shock who were admitted to an intensive care unit were studied.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "299", "sentence": "The control group consisted of 24 healthy laboratory employees.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }