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Enelpol 10

Which is the most common editing modification in eukaryotic mRNA?

One of the most common forms of pre-mRNA editing is A-to-I editing, in which adenosine is deaminated to inosine, which is read as guanosine during translation.

Which histone modifications are associated with constitutive heterochromatin?

Strong methylation at H3 lysine 9 occurred preferentially in heterochromatic chromocenters of Arabidopsis nuclei. In general, heterochromatin has been linked to trimethylation of H3 at lysine 9 and parsimony analysis reveal that histone H3K9 methylation is, next to histone deacetylation, the evolutionary most stable heterochromatic mark. Classical histone modifications associated with heterochromatin also include H3K27me1 and H3K27me2. H3K36me3 function is not restricted to actively transcribed regions only and may contribute to the composition of heterochromatin. Other histone methylation marks usually found in constitutive heterochromatin are H4K20me3, H3K9me3, and H3K79me3. H3S10P is a good marker of pericentromeric heterochromatin.

Is Downs syndrome associated with decreased risk of leukemia?

No, multiple studies have established the incidence of leukemia in Down's syndrome patients to be 10- to 20-fold higher than that in the general population.

Which enzyme is inhibited by Imetelstat?

Imetelstat works by inhibiting telomerase.

When did delafloxacin receive its first approval in the USA for acute bacterial skin and skin structure infections?

Delafoxacin received approval in the USA for the treatment of acute bacterial skin and skin structure infections in 2017.

What are the end products of the shikimate pathway?

The shikimate pathway responsible for the generation of aromatic amino acids

Dasatinib and Blinatumomab are used for treatment of which disease?

Dasatinib and Blinatumomab produces molecular responses in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.

Which genes are responsible for the high-altitude adaptation of Tibetans?

Recent studies have identified genes involved in high-altitude adaptation in Tibetans. Genetic variants/haplotypes within regions containing three of these genes (EPAS1, EGLN1, and PPARA) are associated with relatively decreased hemoglobin levels observed in Tibetans at high altitude, providing corroborative evidence for genetic adaptation to this extreme environment. A gene (HMOX2) involved in heme catabolism, harbors potentially adaptive variants in Tibetans.

What is included in the fourth generation HIV test?

Fourth generation assays detect simultaneously antibodies for HIV and the p24 antigen. It identifies HIV infection earlier than previous generation tests.

Is butterfly rash a symptom of Systemic lupus erythematosus?

Yes, butterfly rash is symptom of Systemic lupus erythematosus.

Is stop codon bypass possible?

In 1999, proof-of-concept for treating these disorders was obtained in a mouse model of muscular dystrophy, when administration of aminoglycosides restored protein translation by inducing the ribosome to bypass a PTC. Aminoglycosides can bypass nonsense mutations and are the prototypic agents for translational bypass therapy (TBT). Expression of retroviral replication enzymes (Pol) requires a controlled translational recoding event to bypass the stop codon at the end of gag. This recoding event occurs either by direct suppression of termination via the insertion of an amino acid at the stop codon (readthrough) or by alteration of the mRNA reading frame (frameshift).

Do thyroid hormone receptors change after brain injury?

thyroid hormone receptors increase after brain injury

Which R/bioconductor package utilizes the Hilbert curve in order to visualize genomic data?

The so-called Hilbert curve visualization can complement genome browsers and help to get further insights into the structure of one's data. An open-source application, called HilbertVis, has been developed for R/bioconductor that allows the user to produce and interactively explore such plots.

What is being measured with an accelerometer in back pain patients

Accelerometer assessment measuring overall physical activity (PAL), constant strain postures (CSP), standing time (ST) and lying time (LT)... The following parameters of physical activity were recorded: time upright (standing or walking), time standing, time walking, and step count.

Can parasite infections by Schistosoma japonicum prevent or improve asthma?

A peptide named as SJMHE1 from Schistosoma japonicum can suppress asthma in mice.

Are CpG islands located close to housekeeping genes?

Our analysis indicates that the association of CGIs with housekeeping genes is not as strong as previously estimated. These regions represent about 1% of genomic DNA and are generally found in the promoter region of housekeeping genes. In housekeeping and many tissue-specific genes, the promoter is embedded in a so-called CpG island. Methylation-free CpG clusters, so-called HTF islands, are most often associated with the promoter regions of housekeeping genes, whereas genes expressed in a single-cell type are usually deficient in these sequences. All housekeeping and widely expressed genes have a CpG island covering the transcription start, whereas 40% of the genes with a tissue-specific or limited expression are associated with islands. It has been envisaged that CpG islands are often observed near the transcriptional start sites (TSS) of housekeeping genes. CpG islands, which are found almost exclusively at the 5'-end of housekeeping genes. CpG islands were associated with the 5' ends of all housekeeping genes and many tissue-specific genes, and with the 3' ends of some tissue-specific genes.

Which translocation is the hallmark of Ewing sarcoma?

Tumours defined as Ewing sarcoma (ES) constitute a group of highly malignant neoplasms that most often affect children and young adults in the first 2 decades of life. The EWS/Fli-1 fusion gene, a product of the translocation t(11;22) (q24; 12), is detected in 95% of ES patients

What is the advantage of using long nano columns in proteomics?

The longer the columns, the longer gradients are applied and finally more proteins (increased peak capacity) are identified in a complex proteomic experiment

Which T-UCR has been implicated in prostate cancer?

Transcribed ultraconserved region Uc.63+ promotes resistance to docetaxel through regulation of androgen receptor signaling in prostate cancer. Docetaxel is the standard chemotherapy for metastatic castration-resistant prostate cancer ( CRPC). However, nearly all patients ultimately become refractory due to the development of docetaxel resistance.

On what chromosome would the MKKS gene for McKusick-Kaufman(AKA Kaufman-McKusick) syndrome be found?

The MKKS gene is mapped to chromosome 20

What is the relationship between thyroid hormone and inflammatory markers in heart failure patients?

There is an inverse correlation between inflammatory markers (IL-6 and TNF alfa and PCR) and FT3 levels in patients with heart failure

How is the sequence variability defined in antibodies?

The variability at each position of the polypeptide chain is defined as: Variability = number of different amino acids at a given position / frequency of the most common amino acid at given position.

Is there any software for automated analysis of immuno-histochemistry images?

In some studies of breast cancer, quantitation of immunohistochemically highlighted microvessel ‘hot spots’ has been shown to be a powerful prognostic tool. However, the antibody used, the number and size of the ‘hot spots’ assessed, and the stratification of patients into high and low vascular groups vary between studies. Furthermore, little is known about the relationship between microvessel density and other vascular parameters. These uncertainties and the laborious nature of the technique make it unsuitable for diagnostic practice. Both manual and computerized image analysis techniques were used in this study to examine the relationship between microvessel density and the vascular parameters in different sized microscopic fields in a pilot series of 30 invasive breast carcinomas. Automated pixel analysis of immunohistochemical staining, Chalkley point counting, and observer subjective vascular grading were also assessed as more rapid methods of measuring tumour vascularity

List proteins with RING domain.

RING1 TRIM proteins TRAF6 UHRF1 MARCH7 SINA BRCA1

What is the mechanism of action of Pitolisant?

Pitolisant is an antagonist/inverse agonist of the human histamine H3 receptor thus increasing histaminergic tone in the wake promoting system of the brain. It is used for the treatment of narcolepsy.

Can Logic Alignment Free (LAF) be used for bacterial genomes classification?

Yes. Logic Alignment Free (LAF), a method that combines alignment-free techniques and rule-based classification algorithms can be used in order to assign biological samples to their taxa.

Can DNA intercalators function as topoisomerase inhibitors?

The DNA unwinding suggests DNA intercalation, which could explain the inhibition of topoisomerase II. Among its many properties, amiloride is a DNA intercalator and topoisomerase II inhibitor. Amsacrine, a DNA intercalator and topoisomerase II inhibitor, is efficacious as an antileukemogenic agent. AQ4N (1,4-bis[[2-(dimethylamino)ethyl] amino]-5,8-dihydroxyanthracene-9, 10-dione bis-N-oxide dihydrochloride) is a prodrug which is selectively activated within hypoxic tissues to AQ4, a topoisomerase II inhibitor and DNA intercalator. Amonafide is a DNA intercalator and topoisomerase II inhibitor in clinical development for the treatment of neoplastic diseases.

Which is the neurodevelopmental disorder associated to mutations in the X- linked gene mecp2?

The neurodevelopmental disorder named Rett syndrome, originally termed as cerebroatrophic hyperammonemia. Although most exclusively affects females, has also been found in male patients.

Which are the available biomedical text mining tools for the detection of protein-protein interactions?

Protein-protein interactions (PPI) can be extracted from biomedical literature using text mining approaches. These approaches have been classified into two categories, the statistical calculation of the co-occurrence of proteins and the computational linguistic method. Moreover, bioinformatics methods based on sequence, structural, or evolutionary information have been developed to predict protein-protein interactions. The available state-of-the-art biomedical text mining tools are: eFIP (Extracting Functional Impact of Phosphorylation), a system for text mining of protein interaction networks of phosphorylated proteins; GeneView, a suite of state-of-the-art text-mining tools designed for the automated identification of protein–protein interactions; PPI finder, a text mining tool for human protein-protein interactions based on computational linguistic methods. PPI Finder system consists of the Information Retrieval module and Information Extraction module; PreBIND and Textomy are two components of a biomedical literature-mining system optimized to discover protein-protein interactions using a support vector machine; BioMap system is optimized for the identification of protein-protein interactions from large biomedical literature datasets; Protopia searches for and integrates protein-protein interactions and the information about them contained in five different Protein Interaction Web Databases; STRING uses Natural Language Processing to extract a subset of semantically specified known and predicted protein-protein interactions.

Is Doxorubicin cardiotoxic?

Doxorubicin (DOXO) is widely used to treat solid tumors. However, its clinical use is limited by side effects including serious cardiotoxicity due to cardiomyocyte damage

Does Groucho related gene 5 (GRG5) have a role only in late development?

Groucho related gene 5 (GRG5) has been described as a multifunctional protein that has been implicated in late embryonic and postnatal mouse development. By both loss and gain of function approaches ablation of GRG5 has been shown to deregulate the Embryonic Stem Cell (ESC) pluripotent state whereas its overexpression leads to enhanced self-renewal and acquisition of cancer cell-like properties. The malignant characteristics of teratomas generated by ESCs that overexpress GRG5 reveal its pro-oncogenic potential.

Is there any protein that undergoes both mono-ubiquitination and poly-ubiquitination?

Yes, there are some rare cases where a protein can be both mono-ubiquitinated and poly-ubiquitinated.

What are there sex differences in SAMHD1 activity?

The host restriction factor SAMHD1 exists in a hyperphosphorylated, less active state in male-derived macrophages. SAMHD1 is an essential modulator of infectivity in a sex-dependent manner in macrophages, constituting a novel component of sex differences in innate immune control of HIV-1.

Is Impetigo a viral infection that affects the skin?

No, impetigo is a highly contagious bacterial skin infection

What is the outcome of TAF10 interacting with the GATA1 transcription factor?

TAF10 Interacts with the GATA1 Transcription Factor and Controls Mouse Erythropoiesis.

Is factor XI deficient in Hemophilia C?

Factor XI deficiency is associated with a bleeding tendency called Hemophilia C.

What is the Arnold-Chiari syndrome?

Arnold Chiari syndrome is a condition characterized by herniation of the cerebellar tonsils through the foramen magnum, manifesting usually with downbeat nystagmus, palsy of the caudal cerebral nerves, headache, and vertigo.

How many genera comprise the Flaviviridae family?

The family Flaviviridae is comprised of three genera: Flavivirus, Pestivirus and Hepacivirus.

Does simvastatin improve outcomes of aneurysmal subarachnoid hemorrhage?

No. Simvastatin showed no benefits in decreasing the incidence of vasospasm, DCI, or all-cause mortality after aneurysmal subarachnoid hemorrhage. Patients with aneurysmal subarachnoid hemorrhage should not be treated routinely with simvastatin during the acute stage.

Which are the main G1/S transcription factors in yeast?

MBF/SBF is the major transcriptional repressor of G1/S genes in Saccharomyces cerevisiae.

Which is the main CHEK2 genetic variant, thought to be involved in familial breast cancer?

CHEK2 1100delC mutation is recurrently detected in the general population and is thought to confer a moderate risk for breast cancer.

What is crenezumab?

Crenezumab is a humanized antibody targeting Amyloid-β (Aβ) which is currently tested in multiple clinical trials for the prevention of Alzheimer's disease. It strongly reacts with amyloid plaques and detects N-terminally modified Aβ peptides Aβ4-42 and pyroglutamate Aβ3-42.

What is the half-life of epimutations across generations of C. elegans?

In C. elegans, epimutations typically have short half-lives of two to three generations. Nevertheless, some epimutations last at least ten generations.

List the drug targets of Faricimab?

Faricimab, a bispecific antibody that inhibits VEGF-A and Ang-2.

How large is the SARS-CoV proteome?

The severe acute respiratory syndrome coronavirus (SARS-CoV) genome is predicted to encode 14 functional open reading frames, leading to the expression of up to 30 structural and non-structural protein products.

Which clinical trials led to the first approval of Volanesorsen by the EU?

The approval of Volanesorsen by the EU was based on the positive results from the multinational, phase III APPROACH and COMPASS studies.

List diseases associated with the Dopamine Receptor D4 (DRD4).

The 5-repeat allele of a common length polymorphism in the gene that encodes the dopamine D4 receptor (DRD4) is robustly associated with the risk of attention deficit hyperactivity disorder (ADHD).

What are the most common side effects of amantadine ER?

The most common side effects of amantadine ER are hallucination, dizziness, orthostatic hypotension and pedal edema.

How can DUF families be deciphered?

The genome projects have unearthed an enormous diversity of genes of unknown function that are still awaiting biological and biochemical characterization. These genes, as most others, can be grouped into families based on sequence similarity. The PFAM database currently contains over 2,200 such families, referred to as domains of unknown function (DUF). Critically examining domain covariation across metagenomic datasets can grant new perspectives on the roles and associations of DUFs in an ecological setting. Targeted attempts at DUF characterization in the laboratory or in silico may draw from these insights and opportunities to discover new associations and corroborate existing ones will arise as more large-scale metagenomic datasets emerge. In a coordinated effort, the four large-scale centers of the NIH Protein Structure Initiative have determined the first three-dimensional structures for more than 250 of these DUF families.

Which proteins does the p85α interact with?

p85α interacts with itself, with p110α and with p110d

Can vitamin B1 deficiency cause encephalopathy?

Wernicke's encephalopathy (WE) is a severe neurological syndrome caused by thiamine (vitamin B1) deficiency and clinically characterized by the sudden onset of mental status changes, ocular abnormalities, and ataxia. It is commonly associated with heavy alcohol consumption. Other clinical associations are with hyperemesis gravidarum (HG), starvation, and prolonged intravenous feeding.

Can radius fracture cause carpal tunnel syndrome?

Yes, carpal tunnel syndrome is a common complication associated with distal radius fractures.

Is NOD1 activated in inflammation?

Nod proteins fight off bacterial infections by stimulating proinflammatory signaling and cytokine networks and by inducing antimicrobial effectors, such as nitric oxide and antimicrobial peptides. NOD1 engagement generates an inflammatory response via activation of NFκB and MAPK pathways and several inflammatory disorders, such as Crohn's disease and asthma, are linked to genetic changes in either Nod1 or Nod2. Nod1 is also critically implicated in shaping adaptive immune responses towards bacterial-derived constituents. Together, Nod1 and Nod2 represent central players in the control of immune responses to bacterial infections and inflammation. Mice deficient for both Nod1 and Nod2 had attenuated inflammatory pathology, reduced levels of inflammatory cytokines, and increased colonization of the mucosal tissue

What is known about thalidomide therapy and survival of glioblastoma patients?

Findings regarding clinical value of thalidomide in terms of survival in patients with glioblastoma remain mixed. It has been shown that thalidomide can improve survival of recurrent glioblastoma patients. However, other authors have not confirmed these findings. Furthermore, thalidomide did not improve survival of newly diagnosed glioblastoma and pediatric glioblastoma patients.

What is the role of the Ctf4-interacting-peptide or CIP-box?

Crystallographic analysis classifies CIP-boxes into two related groups that target different sites on Ctf4. Mutations in the CIP-box motifs of the Dna2 nuclease or the rDNA-associated protein Tof2 do not perturb DNA synthesis genome-wide, but instead lead to a dramatic shortening of chromosome 12 that contains the large array of rDNA repeats. Data reveal unexpected complexity of Ctf4 function, as a hub that connects multiple accessory factors to the replisome. Most strikingly, Ctf4-dependent recruitment of CIP-box proteins couples other processes to DNA synthesis, including rDNA copy-number regulation.

What micro-RNAs are useful in the diagnosis and prognosis of Heart Failure?

In particular, miR-214, miR-423-5p, appear to be promising for the diagnosis, prognosis and management of HF patients.

List inhibtors targeting the mitochondrial permeability transition pore.

Cyclosporine A Atractyloside N-metyl-4-isoleucine-cyclosporine Sanglifehrin A TRO-19622

What is the mode of inheritance of Facioscapulohumeral muscular dystrophy (FSHD)?

The mode of inheritance of Facioscapulohumeral muscular dystrophy is autosomal dominant.

List fish anti-freeze proteins.

AFP-I AFP-II AFP-III Anti-freeze glycoprotein Thermal hysteresis protein

Describe Heyde syndrome.

Classical Heyde syndrome is described as the association of aortic stenosis, bleeding gastrointestinal angiodysplasia and secondary anemia. A deficiency of high molecular weight multimers of von Willebrand factor (type 2A von Willebrand disease) provides the link between this association.

Is thrombophilia related to increased risk of miscarriage?

Thrombophilia has been found to be considerably more common in women with pregnancy-associated complications in comparison with the general population, and most frequently in conjunction with venous thromboembolism during pregnancy and the postpartum period. In particular there is an increased risk of pregnancy-related venous thrombosis in carriers of severe inherited thrombophilia. When counseling white women with a history of preeclampsia, screening for thrombophilia can be useful for preconceptional counseling and pregnancy management.

When was galcanezumab approved by FDA?

Galcanezumab was approved by the FDA in September 2018.

Does triiodothyronine (T3) has cardiac angiogenic effects?

T3-induced cardiac sprouting angiogenesis in adult hypothyroid mice was associated with PDGF-BB, PDGFR-β and downstream activation of Akt. T(3) administration restored TRbeta mRNA expression level in AAC hearts to the control level. TRbeta in the coronary ECs regulates capillary density during cardiac development, and down-regulation of TRbeta results in coronary microvascular rarefaction during pathological hypertrophy.

Are recessive coding variants responsible for the majority of undiagnosed nonconsanguineous individuals?

No. It is suggested that recessive coding variants account for a small fraction of currently undiagnosed nonconsanguineous individuals, and that the role of noncoding variants, incomplete penetrance, and polygenic mechanisms need further exploration.

How can the fetal Rhesus be determined with non-invasive testing?

The detection of fetal RhD status can be achieved with the non-invasive method of assessing free fetal DNA in the maternal blood.

Which disease is rated using the Fahn-Tolosa-Marin scale?

The Fahn-Tolosa-Marin clinical tremor rating scale is used for essential tremor.

What is the mechanism of action of Vericiguat?

Vericiguat is a stimulator of soluble guanylate cyclase. It was developed for treatment of chronic heart failure with reduced ejection fraction.

Which metabolite activates AtxA?

Upon infection of a mammalian host, Bacillus anthracis responds to host cues, and particularly to elevated temperature (37°C) and bicarbonate/CO2 concentrations, with increased expression of virulence factors that include the anthrax toxins and extracellular capsular layer. Cultures grown with elevated CO(2) /bicarbonate exhibited increased AtxA dimer/monomer ratios and increased AtxA activity, relative to cultures grown without added CO(2) /bicarbonate, suggesting that this host-associated signal enhances AtxA function by shifting the dimer/monomer equilibrium towards the dimeric state. CO2-enhanced toxin gene transcription is not observed in atx4-null mutants. Overall data indicate a clear association of atxA with CO2-enhanced gene expression in B. anthracis and provide evidence that atxA regulates genes other than the structural genes for the anthrax toxin proteins.

What is the catalytic mechanism of DNA (cytosine-5) methyltransferases?

The catalytic mechanism of the DNA (Cytosine-5-)-methyltransferase involves nucleophilic attack of the C6 of the substrate cytosine by the single conserved cysteine of the enzyme, followed by C5 nucleophilic replacement of the methyl group of the cofactor S-adenosyl-L-methionine (AdoMet) to produce 5-methyl-6-Cys-81-S-5,6-dihydrocytosine. It has been also demonstrated that Phe and Glu, which are found in the catalytic motifs I and II of the enzyme are important for AdoMet binding and catalysis.

What is apelin?

Apelin, a small regulatory peptide, is the endogenous ligand for the apelin receptor (APJ) receptor.

Which conditions is caused by mutations in HFE?

Mutations in the HFE gene, encoding the syntaxin binding protein HFE1, are the cause of hereditary hemochromatosis.

Which gene controls the expression of GATA-1 isoforms?

In this study, we report a transcriptional network in which PU.1 positively regulates GATA-1 expression in mast cell development. This isoform contains an alternatively spliced first exon (IB) that is distinct from the first exon (IE) incorporated in the major erythroid mRNA transcript.

What is caused by bi-allelic loss-of-function variants in IPO8?

Bi-allelic loss-of-function variants in IPO8 cause a syndromic form of thoracic aortic aneurysm (TAA) with clinical overlap with Loeys-Dietz and Shprintzen-Goldberg syndromes.

What is CRAO in the context of the eye?

central retinal artery occlusion (CRAO) is an ophthalmological emergency, the retinal analog of a stroke.

What is Neuromedin U (NmU)

Neuromedin U (NmU) is a highly conserved neuropeptide and has multiple physiological and pathophysiological roles detected, ranging from smooth muscle contraction, feeding, energy balance to tumorigenesis, stress responses, and inflammation.

Which drugs are included in the EE-4A regimen for Wilm's tumor?

EE-4A regimen includes dactinomycin and vincristine.

Which company produces the HercepTest?

DAKO is the company producing the companion diagnostic HercepTest.

How many copies of TP53 does the elephant genome contain?

Here, we show that the elephant genome encodes 20 copies of the tumor suppressor gene TP53 and that the increase in TP53 copy number occurred coincident with the evolution of large body sizes, the evolution of extreme sensitivity to genotoxic stress, and a hyperactive TP53 signaling pathway in the elephant (Proboscidean) lineage. While humans have 1 copy (2 alleles) of TP53, African elephants have at least 20 copies (40 alleles), including 19 retrogenes (38 alleles) with evidence of transcriptional activity measured by reverse transcription polymerase chain reaction.

Which protein family is epiregulin a member of?

EREG (epiregulin), a member of the epidermal growth factor (EGF) family.

What is an operon?

An operon is a group of genes linked together in a linear fashion and producing polycistronic mRNA.

What is Piebaldism?

Piebaldism is a rare autosomal dominant disorder of melanocyte development characterized by a congenital white forelock and multiple symmetrical stable hypopigmented or depigmented macules.

What are piRNAs?

PIWI-interacting RNAs (piRNAs) are germline-specific small RNAs that form effector complexes with PIWI proteins (Piwi-piRNA complexes) and play critical roles for preserving genomic integrity by repressing transposable elements (TEs).

What is the role of Lysine 2-hydroxyisobutyrylation?

Lysine 2-hydroxyisobutyrylation (Khib) is a widely distributed active histone mark. This histone mark was initially identified by MS and then validated by chemical and biochemical methods. Histone Khib shows distinct genomic distributions from histone Kac or histone Kcr during male germ cell differentiation. In male germ cells, H4K8hib is associated with active gene transcription in meiotic and post-meiotic cells. In addition, H4K8ac-associated genes are included in and constitute only a subfraction of H4K8hib-labeled genes. The histone Khib mark is conserved and widely distributed, has high stoichiometry and induces a large structural change.

Are G-quadruplexes(G4) possible drug targets for glioblastoma?

The 2H2-6M(4)-oxazole telomestatin derivative (6OTD) targets Glioma stem cells through G4 stabilization and promotion of DNA damage responses. Therefore, G4s are promising therapeutic targets for glioblastoma.

What is the 3D tomography imaging technique for diagnosis of eye disease?

Currently, eye care professionals use optical coherence tomography (OCT) scans to help diagnose eye conditions.

Is hydroxyurea usually used to treated infectious disease?

Hydroxyurea represents the only available disease-modifying therapy for Sickle Cell Anemia (SCA).

Which microRNA is the mediator of the obesity phenotype of patients carrying 1p21.3 microdeletions?

MIR137 is the mediator of the obesity phenotype of patients carrying 1p21.3 microdeletions.

List selective estrogen receptor degraders.

Selective estrogen receptor degraders (SERD) are fulvestrant, RAD1901 and ARN-810. Fulvestrant is the only SERD approved for the treatment of breast cancer.

List human diseases involving genomic imprinting.

Prader Willi Syndrome Angelman syndrome Beckwith-Wiedemann syndrome Hydatidiform mole Cancer Silver-Russell syndrome Diabetes

Have mutations in the Polycomb group been found in human diseases?

Yes, different members of the Polycomb family have been found mutated in diseases such as primary microcephaly, nonsyndromic cleft lip and several cancers (including hemotopoietic malignancies, esophageal carcinoma, head and neck cancer or prostate cancer). Exact anser: Yes

What is Quadracel?

Quadracel (diphtheria and tetanus toxoids and acellular pertussis adsorbed and inactivated poliovirus vaccine, Sanofi Pasteur Inc.) is a new vaccination developed to condense the last dose of both DTaP and IPV so they do not have to be given separately, thus reducing the total number of vaccinations required. In a randomized, controlled, phase 3, pivotal trial, Quadracel proved to be as efficacious and safe as Daptacel (diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed, Sanofi Pasteur Inc.) and IPOL (poliovirus vaccine inactivated, Sanofi Pasteur Inc.), given separately, to children between the ages of 4 and 6 years.

Which gene-defect causes the Vel-blood type?

A cohort of 70 Vel- individuals was found to be uniformly homozygous for a 17 nucleotide deletion in the coding sequence of SMIM

Can saponins be used as adjuvant?

Yes, saponin is an ideal adjuvant candidate.

What is known as the cause of subacute thyroiditis?

Most cases of subacute thyroiditis are caused by a variety of viruses, for example, Coxsackie, cytomegalovirus, Epstein-Barr virus, and adenovirus

Is tocilizumab a tumor necrosis factor inhibitor?

No, tocilizumab, is a non-TNFi DMARD.

What is the function of yeast Clr4 on chromatin?

Clr4 is known to regulate silencing and switching at the mating-type loci and to affect chromatin structure at centromeres. The Clr4 methyltransferase determines the subnuclear localization of the mating-type region in fission yeast. Heterochromatin assembly in fission yeast depends on the Clr4 histone methyltransferase, which targets H3K9.

Does physical activity influence gut hormones?

Yes.

What is Hikikomori syndrome?

The 'Hikikomori' syndrome (HS) consists of prolonged and severe social withdrawal.

Which cells secrete lactotransferrin?

We conclude that lactotransferrin represents a late stage differentiation marker of neutrophils, macrophages and distinct subtypes of dendritic cells.

Which are the symptoms of glucose-6-phosphate dehydrogenase (G6PD) deficiency?

Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is the most common red blood cell (RBC) enzyme disorder. The decrease as well as the absence of the enzyme increase RBC vulnerability to oxidative stress caused by exposure to certain medications or intake of fava beans. Among the most common symptoms of this condition are: 1) acute hemolysis, 2) chronic hemolysis, 3) neonatal hyperbilirubinemia.