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Using 1-(tert-butyl) 3-methyl 4-oxopiperidine-1,3-dicarboxylate to produce 1-(tert-butyl) 3-methyl 4-hydroxypiperidine-1,3-dicarboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCN(CC)CC", "CO"], "agent": ["[Na+]", "Cl", "[BH4-]"]} |
Using 7H-benzo[3,4]azepino[1,2-a]indole-6,10-dicarboxamide to produce 5H-benzo[3,4]azepino[1,2-a]indole-6,10-dicarboxamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["[Pd]"]} |
Using 5-(4-(benzyloxy)phenoxy)quinazoline-2,4-diamine to produce 4-((2,4-diaminoquinazolin-5-yl)oxy)phenol, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC(=O)N(C)C"], "agent": ["[Pd]"]} |
Using 3,4-dihydroquinolin-2(1H)-one, benzoylchloride to produce 6-benzoyl-3,4-dihydroquinolin-2(1H)-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["[Al+3]", "[Cl-]", "Cl"]} |
Using azide, 2-chloro-8-methylquinoxaline to produce 9-methyltetrazolo[1,5-a]quinoxaline, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCO"], "agent": ["[Na+]", "Cl"]} |
Using 2,3,5,6-tetrachloropyridine to produce 2,3,5-trichloropyridine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O"], "agent": ["[Zn]"]} |
Using (3S)-5-([1,1'-biphenyl]-4-ylmethyl)-3-benzoyl-1-((E)-styryl)pyrrolidin-2-one to produce (R,E)-5-([1,1'-biphenyl]-4-ylmethyl)-3-methylene-1-styrylpyrrolidin-2-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["O=C([O-])[O-]", "[K+]", "C=O"]} |
Using tert-butyl (S)-3-(4-(3-(benzhydryloxy)-2-((tert-butoxycarbonyl)amino)-3-oxopropyl)phenyl)acrylate to produce (S)-3-(4-(3-(tert-butoxy)-3-oxopropyl)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC(C)(C)O"], "agent": ["[H][H]", "[Pd]"]} |
Using 4-(6-((methylsulfonyl)oxy)-3-(4-(2-(pyrrolidin-1-yl)ethoxy)benzoyl)benzo[b]thiophen-2-yl)phenyl methanesulfonate to produce (6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)methanone, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCO"], "agent": ["[Na+]", "Cl", "[OH-]"]} |
Using 2-(3-(pyridin-4-yl)propyl)isoindoline-1,3-dione to produce 3-(pyridin-4-yl)propan-1-amine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["NN"]} |
Using 1,5-dimethyl-N-(3-(2-oxoindoline-6-carbonyl)phenyl)-1H-pyrazole-4-carboxamide, ethylformate to produce N-(3-(3-(hydroxymethylene)-2-oxoindoline-6-carbonyl)phenyl)-1,5-dimethyl-1H-pyrazole-4-carboxamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCO"], "agent": ["[Na+]", "Cl", "CC[O-]"]} |
Using ethanol, 4-(4-amino-3-nitropyridin-1(2H)-yl)benzonitrile to produce 4-((3-aminopyridin-4-yl)amino)benzonitrile, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O"], "agent": ["Cl[Sn]Cl"]} |
Using ethyl 2-(diethoxyphosphoryl)acetate, tert-butyl 4-oxopiperidine-1-carboxylate to produce tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["[Na+]", "[H-]"]} |
Using iodomethane, benzyl cyclopropylcarbamate to produce benzyl cyclopropyl(methyl)carbamate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O", "C1CCOC1"], "agent": ["[Na+]", "[H-]"]} |
Using methyl 3-((2-amino-2-oxoethyl)thio)-2-chloropropanoate to produce methyl 2-chloro-3-((cyanomethyl)thio)propanoate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O"], "agent": ["Cc1ccc(S(=O)(=O)Cl)cc1"]} |
Using (4-formylphenyl)boronic acid, 5-bromo-3-(1H-indol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine to produce 4-(3-(1H-indol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzaldehyde, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC#N"], "agent": ["O=C([O-])[O-]", "[Na+]"]} |
Using n,n-dimethylformamide, triphenylamine to produce 4-(diphenylamino)benzaldehyde, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O=P(Cl)(Cl)Cl"], "agent": ["[Na+]", "[OH-]"]} |
Using 4-vinylpyridine, ammonium to produce 2-(pyridin-4-yl)ethan-1-amine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O"], "agent": ["[Cl-]", "[Na+]", "[OH-]"]} |
Using methyl 2-methoxy-5-nitrobenzoate to produce methyl 5-amino-2-methoxybenzoate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["ClCCl", "CO"], "agent": ["[Pd]"]} |
Using 3-(4-bromophenyl)propanoic acid to produce 3-(4-bromophenyl)propan-1-ol, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["O=C([O-])[O-]", "[K+]", "B"]} |
Using ethyl 4-bromobenzoate, ethynyltrimethylsilane to produce ethyl 4-((trimethylsilyl)ethynyl)benzoate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC#N", "CCN(CC)CC"], "agent": ["[Cu]I", "Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1"]} |
Using (2,4-difluorophenyl)magnesium bromide, (R)-3-((tert-butyldimethylsilyl)oxy)-1-chlorobutan-2-one to produce 3-((tert-butyldimethylsilyl)oxy)-1-chloro-2-(2,4-difluorophenyl)butan-2-ol, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "C1CCOC1"], "agent": ["[Cl-]", "[NH4+]"]} |
Using 3,4-dihydro-2H-pyran, 4-bromo-3,5-dimethylphenol to produce 2-(4-bromo-3,5-dimethylphenoxy)tetrahydro-2H-pyran, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["ClC(Cl)Cl"], "agent": ["c1cc[nH+]cc1", "Cc1ccc(S(=O)(=O)[O-])cc1"]} |
Using 1-(4-nitrobenzyl)piperidine to produce 4-(piperidin-1-ylmethyl)aniline, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["[Pd]"]} |
Using 1,4-dimethoxybenzene, (E)-2-methylbut-2-enoyl chloride to produce 4,7-dimethoxy-2,3-dimethyl-2,3-dihydro-1H-inden-1-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["ClCCl"], "agent": ["[Al+3]", "[Cl-]", "Cl"]} |
Using 4,6-dichloropyrimidine, methanethiolate to produce 4-chloro-6-(methylthio)pyrimidine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["[Na+]"]} |
Using 4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-(methylsulfonyl)pyridazin-3(2H)-one, hydroxide to produce 4-(2,6-diethyl-4-methylphenyl)-5-hydroxy-2,6-dimethylpyridazin-3(2H)-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "Cc1ccccc1"], "agent": ["C[N+](C)(C)Cc1ccccc1", "[Cl-]", "[Na+]"]} |
Using cyanate, 2-chloro-5-methoxyaniline to produce 1-(2-chloro-5-methoxyphenyl)urea, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC(=O)O", "O"], "agent": ["[K+]", "Cl"]} |
Using 2,6-dimethylaniline, 2-chloroacetyl chloride to produce 2-chloro-N-(2,6-dimethylphenyl)acetamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "Cc1ccccc1"], "agent": ["O=C([O-])[O-]", "[Na+]"]} |
Using (3aR,7R,7aR)-7-fluoro-4,4-diphenyloctahydro-1H-isoindole, 2-(2-(pyrrolidin-1-yl)phenyl)acetic acid to produce 1-((3aR,7R,7aR)-7-fluoro-4,4-diphenyloctahydro-2H-isoindol-2-yl)-2-(2-(pyrrolidin-1-yl)phenyl)ethan-1-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["ClCCl", "CCN(CC)CC"], "agent": ["O=C(n1ccnc1)n1ccnc1", "Cl"]} |
Using tert-butylchlorodimethylsilane, 6-bromohexan-1-ol to produce ((6-bromohexyl)oxy)(tert-butyl)dimethylsilane, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "CN(C)C=O"], "agent": ["c1c[nH]cn1"]} |
Using tert-butyl 4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate, methyl 3-(bromomethyl)benzoate to produce tert-butyl 3-(3-(methoxycarbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O", "CN(C)C=O"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using N,N-dimethylprop-2-yn-1-amine, (Z)-5-fluoro-4-iodo-3-((4-methyl-1H-imidazol-5-yl)methylene)indolin-2-one to produce (Z)-4-(3-(dimethylamino)prop-1-yn-1-yl)-5-fluoro-3-((4-methyl-1H-imidazol-5-yl)methylene)indolin-2-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O", "CCN(CC)CC"], "agent": ["[Cu]I", "c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1"]} |
Using 4-chloropyridine, ethyl piperidine-4-carboxylate to produce ethyl 1-(pyridin-4-yl)piperidine-4-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN1CCCC1=O", "CN1CCOCC1"], "agent": ["Cl"]} |
Using 6-methoxy-4-(4-nitrophenoxy)quinolin-7-ol, 4-nitrophenyl trifluoromethanesulfonate to produce 6-methoxy-4-(4-nitrophenoxy)quinolin-7-yl trifluoromethanesulfonate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using aceticanhydride, 1,4-bis(2,2,2-trifluoroethoxy)benzene to produce 1-(2,5-bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCCCCC", "ClCCl"], "agent": ["[Al+3]", "[Cl-]", "Cl"]} |
Using 1,3-dichloroisoquinoline to produce 3-chloroisoquinoline, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCO", "O"], "agent": ["NN"]} |
Using 6-methyl-5-((trimethylsilyl)ethynyl)pyridin-2-amine to produce 5-ethynyl-6-methylpyridin-2-amine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using N-(3-ethynylphenyl)-6-nitroquinazolin-4-amine to produce N4-(3-ethynylphenyl)quinazoline-4,6-diamine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O", "O"], "agent": ["[Na+]", "O=C([O-])O", "Cl[Sn]Cl"]} |
Using 3-fluoro-4-hydroxy-5-methoxybenzaldehyde to produce 3-fluoro-4,5-dihydroxybenzaldehyde, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["ClCCl", "c1ccncc1"], "agent": ["[Al+3]", "[Cl-]"]} |
Using tert-butylchlorodimethylsilane, 2-(4-bromophenoxy)ethan-1-ol to produce (2-(4-bromophenoxy)ethoxy)(tert-butyl)dimethylsilane, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["ClCCl", "CCN(CC)CC"], "agent": ["CN(C)c1ccncc1"]} |
Using (R)-oxiran-2-ylmethyl 4-methylbenzenesulfonate, 5-bromo-2-hydroxybenzaldehyde to produce (R)-5-bromo-2-(oxiran-2-ylmethoxy)benzaldehyde, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O", "O"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using N-cyclopropyl-3-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide, methyl 6-chloronicotinate to produce 6-(5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl)nicotinic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC(C)O"], "agent": ["[Na+]", "O=C([O-])O"]} |
Using 2-((1r,4r)-4-(dibenzylamino)cyclohexyl)propan-2-ol to produce 2-((1r,4r)-4-aminocyclohexyl)propan-2-ol, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCO"], "agent": ["[OH-]", "[Pd+2]"]} |
Using 2-hydrazineyl-3,5-dinitropyridine to produce 3,5-dinitropyridine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "CO"], "agent": ["CC(=O)[O-]", "[Ag+]"]} |
Using 3,4-dimethoxybenzoic acid, methyl (S)-2-((3S,8S)-3-(4-((3,4-dichlorobenzyl)oxy)phenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carboxamido)-3-(4-((2,3-dimethylpyridin-4-yl)oxy)phenyl)propanoate to produce (S)-2-((3S,8S)-3-(4-((3,4-dichlorobenzyl)oxy)phenyl)-7-(3,4-dimethoxybenzoyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carboxamido)-3-(4-((2,3-dimethylpyridin-4-yl)oxy)phenyl)propanoic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["ClCCl"], "agent": ["CCN=C=NCCCN(C)C"]} |
Using tert-butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate to produce tert-butyl 4-(4-amino-2-cyanophenyl)piperazine-1-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "CCO"], "agent": ["[Cl-]", "[Fe]", "[NH4+]"]} |
Using ethyl 2-bromoacetate, 4-hydroxybenzaldehyde to produce ethyl 2-(4-formylphenoxy)acetate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "CN(C)C=O"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using (bromomethyl)benzene, indoline-2,3-dione to produce 1-benzylindoline-2,3-dione, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["[Na+]", "[H-]"]} |
Using 3-methyl-N-phenylbut-2-enamide to produce 4,4-dimethyl-3,4-dihydroquinolin-2(1H)-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["ClCCl"], "agent": ["[Al+3]", "[Cl-]", "Cl"]} |
Using trimethyl((tributylstannyl)ethynyl)silane, ethyl 5-bromo-1-cyclopropyl-6,8-difluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate to produce ethyl 1-cyclopropyl-6,8-difluoro-7-(4-methylpiperazin-1-yl)-4-oxo-5-(trimethylsilyl)-1,4-dihydroquinoline-3-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["Cc1ccccc1"], "agent": ["c1ccc(P(c2ccccc2)c2ccccc2)cc1", "[Pd]"]} |
Using carbonate, 4-hydroxy-2,3-dihydro-1H-inden-1-one to produce 4-methoxy-2,3-dihydro-1H-inden-1-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O", "CI"], "agent": ["[K+]"]} |
Using 5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoic acid to produce 5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC(C)O"], "agent": ["[Na+]", "[OH-]"]} |
Using N-(1-(5-bromopyridin-3-yl)-2,2,2-trifluoroethyl)-2-methylpropane-2-sulfinamide to produce 1-(5-bromopyridin-3-yl)-2,2,2-trifluoroethan-1-amine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["Cl"]} |
Using methyl 1H-indole-5-carboxylate to produce methyl indoline-5-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC(=O)O"], "agent": ["[BH3-]C#N", "[Na+]"]} |
Using 2-bromobenzaldehyde, 1-bromo-4-chlorobenzene to produce (2-bromophenyl)(4-chlorophenyl)methanol, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCCCCC", "C1CCOC1"], "agent": ["[Li]CCCC"]} |
Using methyl 2',4'-difluoro-[1,1'-biphenyl]-4-carboxylate to produce 2',4'-difluoro-[1,1'-biphenyl]-4-carboxylic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1COCCO1"], "agent": ["[Na+]", "Cl", "[OH-]"]} |
Using 2-iodo-5-methoxyphenol, prop-1-yne to produce 6-methoxy-2-methylbenzofuran, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["[Cl-]", "[Na+]", "CN(C)C(=N)N(C)C"]} |
Using 4-((8-cyclohexyloctyl)amino)benzoyl chloride, 4-chlorophenol to produce 4-chlorophenyl 4-((8-cyclohexyloctyl)amino)benzoate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["ClCCl", "CCN(CC)CC"], "agent": ["[Cl-]", "Cl"]} |
Using 1H-imidazole, 2-fluorobenzonitrile to produce 2-(1H-imidazol-1-yl)benzonitrile, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC#N"], "agent": ["[Na]"]} |
Using dimethylsulfamoyl chloride, 1H-pyrazole to produce N,N-dimethyl-1H-pyrazole-1-sulfonamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "C1CCOC1"], "agent": ["[Na+]", "[H-]"]} |
Using 3-(2-methyl-4-nitrophenyl)-1,3-oxazepan-2-one to produce 3-(4-amino-2-methylphenyl)-1,3-oxazepan-2-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["[H][H]", "[Ni]"]} |
Using 2-fluoroethyl 4-methylbenzenesulfonate, tert-butyl 3-oxopiperazine-1-carboxylate to produce tert-butyl 4-(2-fluoroethyl)-3-oxopiperazine-1-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["CC(C)(C)[O-]"]} |
Using nitricacid, 1-bromo-4-(tert-butyl)benzene to produce 1-bromo-4-(tert-butyl)-2-nitrobenzene, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O"], "agent": ["O=S(=O)(O)O"]} |
Using 1-bromohexane, 4-bromophenol to produce 1-bromo-4-(hexyloxy)benzene, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["[Na+]", "N#N", "[H-]"]} |
Using diisopropylamide, N-((4-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)phenethyl)carbamoyl)-4-methylbenzenesulfonamide to produce N-((4-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)phenethyl)carbamoyl)-N,4-dimethylbenzenesulfonamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["[Li+]", "O=P([O-])([O-])[O-]"]} |
Using methyl 5-chloro-4-(1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxylate to produce 5-chloro-4-(1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxylic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1", "CO"], "agent": ["[Na+]", "[OH-]"]} |
Using 3-(3-(trifluoromethyl)phenyl)acrylic acid to produce 3-(3-(trifluoromethyl)phenyl)propanoic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["[Pd]"]} |
Using pivaloyl chloride, 6-chloro-N2-ethylpyrimidine-2,4-diamine to produce N-(6-chloro-2-(ethylamino)pyrimidin-4-yl)pivalamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCN(CC)CC"], "agent": ["O=C([O-])[O-]", "[Na+]"]} |
Using hydroxylamine, cyclohexanecarbaldehyde to produce cyclohexanecarbaldehyde oxime, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCO", "c1ccncc1"], "agent": ["Cl"]} |
Using (bromomethyl)benzene, methyl 6-chloro-5-hydroxynicotinate to produce methyl 5-(benzyloxy)-6-chloronicotinate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O", "O"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using nnm, 4-((4-methyl-2-nitrophenyl)thio)benzoic acid to produce 4-((4-methyl-2-nitrophenyl)thio)benzamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "C1CCOC1"], "agent": ["CC(C)COC(=O)Cl", "N"]} |
Using 5-chloro-2-hydroxybenzaldehyde, methyl 2-bromoacetate to produce methyl 2-(4-chloro-2-formylphenoxy)acetate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using tert-butylchlorodimethylsilane, 3-aminopropan-1-ol to produce 3-((tert-butyldimethylsilyl)oxy)propan-1-amine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOCC", "C1CCOC1"], "agent": ["[Na+]", "[H-]"]} |
Using 1-bromopyrrolidine-2,5-dione, methyl 3-bromo-2-methylbenzoate to produce methyl 3-bromo-2-(bromomethyl)benzoate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["ClC(Cl)(Cl)Cl"], "agent": ["O=C(OOC(=O)c1ccccc1)c1ccccc1"]} |
Using 2,5-dichloro-2,5-dimethylhexane, bromobenzene to produce 6-bromo-1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCCCCC", "CCOCC"], "agent": ["[Al+3]", "[Cl-]"]} |
Using 3-(2,4-dichlorophenyl)-1-(1-(propylthio)cyclopropyl)prop-2-en-1-one, dimethylsulfate to produce 2-(2,4-dichlorostyryl)-2-(1-(propylthio)cyclopropyl)oxirane, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CSC", "CC(C)(C)O"], "agent": ["OO", "[K+]", "[OH-]"]} |
Using 1-(4-(3-methoxy-4-nitrophenyl)piperazin-1-yl)ethan-1-one to produce 1-(4-(4-amino-3-methoxyphenyl)piperazin-1-yl)ethan-1-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O", "CCO"], "agent": ["[C]", "[Pd]"]} |
Using methanesulfonyl chloride, (S)-3,4-dihydroxybutanenitrile to produce (S)-3-cyano-2-hydroxypropyl methanesulfonate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["c1ccncc1"], "agent": ["Cl"]} |
Using (tert-butoxycarbonyl)-L-phenylalanine, aniline to produce tert-butyl (S)-(1-oxo-3-phenyl-1-(phenylamino)propan-2-yl)carbamate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["CCN=C=NCCCN(C)C", "Cl"]} |
Using resorcinol, 3-chloropropanoic acid to produce 3-chloro-1-(2,4-dihydroxyphenyl)propan-1-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "ClCCl"], "agent": ["O=S(=O)(O)C(F)(F)F"]} |
Using 3,4-dihydro-2H-pyran, but-2-yne-1,4-diol to produce 4-((tetrahydro-2H-pyran-2-yl)oxy)but-2-yn-1-ol, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOCC"], "agent": ["Cc1ccc(S(=O)(=O)O)cc1"]} |
Using iodide, benzhydryl (6R)-7-((tert-butoxycarbonyl)amino)-3-((Z)-3-chloroprop-1-en-1-yl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate to produce benzhydryl (6R)-7-((tert-butoxycarbonyl)amino)-3-((E)-3-iodoprop-1-en-1-yl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC(C)=O"], "agent": ["[Na+]"]} |
Using acetophenone to produce (S)-1-phenylethan-1-ol, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC(C)O"], "agent": ["[H][H]"]} |
Using (phenoxycarbonyl)-L-valine, 1-(2-isopropylthiazol-4-yl)-N-methylmethanamine to produce (((2-isopropylthiazol-4-yl)methyl)(methyl)carbamoyl)-L-valine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["Oc1ccccc1", "C1CCOC1"], "agent": ["[Na+]", "[OH-]"]} |
Using 2-amino-5-nitrobenzenesulfonamide to produce 2,5-diaminobenzenesulfonamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1", "CO"], "agent": ["[H][H]", "[Pd]"]} |
Using 2-amino-5-nitrobenzenesulfonamide to produce 2,5-diaminobenzenesulfonamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["[H][H]", "[Pd]"]} |
Using ethylacetoacetate, cinnamaldehyde to produce ethyl 3-oxo-1,2,3,6-tetrahydro-[1,1'-biphenyl]-2-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCO"], "agent": ["[Na]", "Cl"]} |
Using (bromomethyl)benzene, 4-bromophenol to produce 1-(benzyloxy)-4-bromobenzene, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using 2-(2,6-dimethylpiperidin-1-yl)acetic acid, 1-hydroxypyrrolidine-2,5-dione to produce 2,5-dioxopyrrolidin-1-yl 2-(2,6-dimethylpiperidin-1-yl)acetate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["Cl"]} |
Using 5-(benzyloxy)-2-methylpyridin-4(1H)-one to produce 5-hydroxy-2-methylpyridin-4(1H)-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "CO"], "agent": ["[H][H]", "Cl", "[Pd]"]} |
Using 2-benzyl 3-(tert-butyl) 5-oxotetrahydrofuran-2,3-dicarboxylate to produce 3-(tert-butoxycarbonyl)-5-oxotetrahydrofuran-2-carboxylic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O"], "agent": ["[H][H]", "[C]", "[Pd]"]} |
Using ethyl (R)-3-(((benzyloxy)carbonyl)amino)-2,5-dioxopyrrolidine-3-carboxylate to produce ethyl (R)-3-amino-2,5-dioxopyrrolidine-3-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCO"], "agent": ["[Pd]"]} |
Using 6-ethoxybenzo[d]thiazole-2-sulfonamide to produce 6-hydroxybenzo[d]thiazole-2-sulfonamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCCCCCC"], "agent": ["[Al+3]", "[Cl-]"]} |
Using ethyl N-(N-(tert-butoxycarbonyl)-N-methylglycyl)-N-methylglycinate to produce N-(N-(tert-butoxycarbonyl)-N-methylglycyl)-N-methylglycine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["[Na+]", "[OH-]"]} |
Using 2,4-dichlorothiazole, morpholine to produce 4-(4-chlorothiazol-2-yl)morpholine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["O=C([O-])[O-]", "[Cs+]"]} |
Using 3-bromopropan-1-ol, 4-(6-bromoimidazo[1,2-a]pyridin-2-yl)phenol to produce 3-(4-(6-bromoimidazo[1,2-a]pyridin-2-yl)phenoxy)propan-1-ol, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using 1,3-dibromopropane, 3-nitrophenol to produce 1-(3-bromopropoxy)-3-nitrobenzene, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC#N"], "agent": ["O=C([O-])[O-]", "[Cs+]"]} |
Using tert-butyl 4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carboxylate to produce 1-(5-ethyl-3-methylpyridin-2-yl)piperazine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O", "ClC(Cl)Cl"], "agent": ["Cl"]} |
Using 4-bromophenol, 2-bromo-5-methoxybenzoic acid to produce 2-(4-bromophenoxy)-5-methoxybenzoic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O", "Cc1ccccc1"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
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