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Using 7-(4-fluorophenyl)-8-(pyridin-4-yl)-1,2,3,4-tetrahydropyrazolo[5,1-c][1,2,4]triazine, 2-(1H-indol-3-yl)acetic acid to produce 1-(7-(4-fluorophenyl)-8-(pyridin-4-yl)-3,4-dihydropyrazolo[5,1-c][1,2,4]triazin-2(1H)-yl)-2-(1H-indol-3-yl)ethan-1-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O", "O"], "agent": ["CCN=C=NCCCN(C)C", "On1nnc2ccccc21"]} |
Using 7-(benzyloxy)-2-ethyl-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazo[4,5-c]quinoline to produce 2-ethyl-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazo[4,5-c]quinolin-7-ol, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC#N", "CO"], "agent": ["[Pd]"]} |
Using dimethyl 4-(2-nitrophenoxy)phthalate to produce dimethyl 4-(2-aminophenoxy)phthalate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["ClCCl"], "agent": ["[Pd]"]} |
Using 3-bromo-2,2,3-trifluoropropanoic acid, 5-(3-chloro-4-isopropoxyphenyl)-3-(1H-indol-5-yl)-1,2,4-oxadiazole to produce 3-(5-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indol-1-yl)-2,2,3-trifluoropropanoic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["O=C([O-])[O-]", "[Cs+]"]} |
Using 2-fluoro-6-hydroxybenzaldehyde, 2-iodopropane to produce 2-fluoro-6-isopropoxybenzaldehyde, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O", "CCOCC"], "agent": ["O=C([O-])[O-]", "[K+]", "[Cs+]"]} |
Using methanolate, 8-bromo-N2-pentyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2,6-diamine to produce 8-methoxy-N2-pentyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2,6-diamine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["[Na+]"]} |
Using 6-bromo-2,3-dihydrobenzofuran, n,n-dimethylformamide to produce 2,3-dihydrobenzofuran-6-carbaldehyde, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["[Li]CCCC"]} |
Using ethyl (3-(7-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indol-3-yl)propanoyl)glycinate to produce (3-(7-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-1H-indol-3-yl)propanoyl)glycine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["[Na+]", "Cl", "[OH-]"]} |
Using ethyl 2-((tert-butoxycarbonyl)amino)-4-methylthiazole-5-carboxylate to produce 2-((tert-butoxycarbonyl)amino)-4-methylthiazole-5-carboxylic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["[Na+]", "[OH-]"]} |
Using 2-(4-fluorophenyl)-1-(4-morpholino-2-(2-phenoxypyrimidine-4-carbonyl)pyrazolidin-1-yl)ethan-1-one to produce 2-(4-fluorophenyl)-6-morpholino-3-(2-phenoxypyrimidin-4-yl)-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["[Na+]", "[H-]"]} |
Using 3-((3-fluorophenyl)ethynyl)-6,7-dihydro-11H-pyrido[2,1-b]quinazoline-8,11(9H)-dione to produce 3-((3-fluorophenyl)ethynyl)-8-hydroxy-6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazolin-11-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["[Na+]", "[BH4-]"]} |
Using 1-bromopyrrolidine-2,5-dione, 2-(tert-butyl)-1-fluoro-4-methylbenzene to produce 4-(bromomethyl)-2-(tert-butyl)-1-fluorobenzene, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["ClC(Cl)(Cl)Cl"], "agent": ["O=C(OOC(=O)c1ccccc1)c1ccccc1"]} |
Using 2-fluorobenzoic acid, 4-nitro-1-(piperidin-4-yloxy)isoquinoline to produce (2-fluorophenyl)(4-((4-nitroisoquinolin-1-yl)oxy)piperidin-1-yl)methanone, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["On1nnc2ccccc21", "C(=NC1CCCCC1)=NC1CCCCC1"]} |
Using hexa-1,5-diene, chlorodimethylsilane to produce chloro(hex-1-en-1-yl)dimethylsilane, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["Cc1ccccc1C"], "agent": ["[Pt]"]} |
Using N-(5-bromo-2-propoxybenzyl)ethanamine, 6-chloropyridazine-3-carbonitrile to produce 6-((5-bromo-2-propoxybenzyl)(ethyl)amino)pyridazine-3-carbonitrile, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O", "CN1CCCC1=O"], "agent": ["[Na+]", "Cl", "O=C([O-])O"]} |
Using (S)-2-((tert-butoxycarbonyl)amino)-3-(pyridin-4-yl)propanoic acid, n-ethyl-n-isopropylpropan-2-amine to produce tert-butyl (R)-(1-oxo-3-(pyridin-4-yl)-1-(pyrrolidin-1-yl)propan-2-yl)carbamate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCNC1", "ClCCl"], "agent": ["CC(C)COC(=O)Cl"]} |
Using 3-(chloromethyl)benzoic acid, 4-((but-3-en-1-yloxy)methyl)benzoic acid to produce 3-(propoxymethyl)benzoic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCCO"], "agent": ["[Na+]", "[H-]"]} |
Using benzhydryl 8a-(((6-(2-ethoxy-2-oxoethoxy)-7-hydroxytetrahydro-2,5-methanofuro[2,3-d][1,3]dioxol-2-yl)oxy)methyl)-4-formyl-3-isopropyl-7-methyl-4,4a,5,6,7,7a,8,8a-octahydro-1,4-methano-s-indacene-3a(1H)-carboxylate to produce 8a-(((6-(2-ethoxy-2-oxoethoxy)-7-hydroxytetrahydro-2,5-methanofuro[2,3-d][1,3]dioxol-2-yl)oxy)methyl)-4-formyl-3-isopropyl-7-methyl-4,4a,5,6,7,7a,8,8a-octahydro-1,4-methano-s-indacene-3a(1H)-carboxylic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O"], "agent": ["[C]", "[Pd]"]} |
Using benzhydryl (6R)-3-(bromomethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate, 4-hydroxybutanoate to produce benzhydryl (6R)-3-(((4-hydroxybutanoyl)oxy)methyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O", "CN(C)P(=O)(N(C)C)N(C)C"], "agent": ["[Na+]"]} |
Using 2,2,2-trichloroethyl carbonochloridate, 3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-amine to produce 2,2,2-trichloroethyl (3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)carbamate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O", "O"], "agent": ["[Na+]", "Cl", "[OH-]"]} |
Using ethyl 2-(3,4-dihydroisoquinolin-2(1H)-yl)-4,6-dimethylpyrimidine-5-carboxylate to produce 2-(3,4-dihydroisoquinolin-2(1H)-yl)-4,6-dimethylpyrimidine-5-carboxylic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCO", "O"], "agent": ["[Na+]", "[OH-]"]} |
Using tert-butyl 4-formylpiperidine-1-carboxylate, 7-(propylamino)-5,6,7,8-tetrahydronaphthalen-2-ol to produce tert-butyl 4-(((7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)methyl)piperidine-1-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC(Cl)Cl"], "agent": ["CC(=O)O[BH-](OC(C)=O)OC(C)=O", "[Na+]"]} |
Using N-((1R,2S)-2-(allyloxy)-6-methoxy-2,3-dihydro-1H-inden-1-yl)-2,2,2-trifluoroacetamide to produce (1R,2S)-2-(allyloxy)-6-methoxy-2,3-dihydro-1H-inden-1-amine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using n,n-dimethylformamide, 1-(3-fluorophenyl)-3-methyl-1H-pyrazole to produce 1-(3-fluorophenyl)-3-methyl-1H-pyrazole-4-carbaldehyde, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O=P(Cl)(Cl)Cl"], "agent": ["[Na+]", "O=C([O-])O"]} |
Using L-cysteine, O-methyl S-(3-(2-oxo-5-phenylimidazolidin-1-yl)propyl) carbonothioate to produce S-((3-(2-oxo-5-phenylimidazolidin-1-yl)propyl)thio)-L-cysteine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "CO"], "agent": ["Cl"]} |
Using 5'-methyl-[1,1':3',1''-terphenyl]-2'-ol, (1,2,3,4,5-pentamethylcyclopenta-2,4-dien-1-yl)titanium(IV) chloride to produce ((5'-methyl-[1,1':3',1''-terphenyl]-2'-yl)oxy)(1,2,3,4,5-pentamethylcyclopenta-2,4-dien-1-yl)titanium(IV) chloride, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["Cc1ccccc1"], "agent": ["[Na+]", "[H-]"]} |
Using tert-butyl ((1r,4r)-4-(2-(methylsulfonyl)vinyl)cyclohexyl)carbamate to produce tert-butyl ((1r,4r)-4-(2-(methylsulfonyl)ethyl)cyclohexyl)carbamate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["[Pd]"]} |
Using 1H-benzo[d]imidazole-2-thiol, 2-bromo-1-phenylethan-1-one to produce 2-((1H-benzo[d]imidazol-2-yl)thio)-1-phenylethan-1-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["[Na+]", "[OH-]"]} |
Using 5-(tributylstannyl)thiazole, 4-(2-chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine to produce 4-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-2-(thiazol-5-yl)thieno[3,2-d]pyrimidin-4-yl)morpholine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC(=O)N(C)C"], "agent": ["c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1"]} |
Using ammonium, ethyl 1-((2R,3S)-3-hydroxy-1-(naphthalen-1-ylthio)butan-2-yl)-1H-imidazole-4-carboxylate to produce 1-((2R,3S)-3-hydroxy-1-(naphthalen-1-ylthio)butan-2-yl)-1H-imidazole-4-carboxamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["COCCOC"], "agent": ["[OH-]"]} |
Using 4-(trifluoromethyl)benzaldehyde, methyl 4-iodobenzoate to produce methyl 4-(hydroxy(4-(trifluoromethyl)phenyl)methyl)benzoate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["CC(C)[Mg]Cl", "N#N"]} |
Using carbon dioxide, 5-bromo-3-(3-fluorophenyl)-4-methoxy-1H-indazole to produce 3-(3-fluorophenyl)-4-methoxy-1H-indazole-5-carboxylic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCCCCC", "C1CCOC1"], "agent": ["[Cl-]", "[NH4+]", "[Li]CCCC"]} |
Using 1-bromo-2-fluoroethane, 4-chloro-5H-pyrrolo[3,2-d]pyrimidine to produce 4-chloro-5-(2-fluoroethyl)-5H-pyrrolo[3,2-d]pyrimidine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O", "O"], "agent": ["O=C([O-])[O-]", "[Cs+]"]} |
Using 2-chloro-5-(3-((trimethylsilyl)oxy)cyclopent-2-en-1-yl)pyridine to produce 3-(6-chloropyridin-3-yl)cyclopentan-1-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O", "C1CCOC1"], "agent": ["[Na+]", "Cl", "O=C([O-])O"]} |
Using (S)-2-amino-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoic acid, phenylalanine to produce prop-2-yn-1-yl 2-amino-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "CO"], "agent": ["[Na+]", "Cl", "[OH-]"]} |
Using diethyl (4-(((benzyloxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoyl)-D-glutamate to produce diethyl (4-amino-5-(tert-butoxy)-5-oxopentanoyl)-D-glutamate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCO"], "agent": ["[Pd]"]} |
Using 4-((3-(azidomethyl)-5-((3,5-dichlorophenyl)thio)-1-isopropyl-1H-pyrazol-4-yl)methyl)pyridine to produce (5-((3,5-dichlorophenyl)thio)-1-isopropyl-4-(pyridin-4-ylmethyl)-1H-pyrazol-3-yl)methanamine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O"], "agent": ["[Pd]"]} |
Using 1,2,3-trifluoro-4-nitrobenzene, ethylacetoacetate to produce 1-(2,3-difluoro-6-nitrophenyl)propan-2-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["[Na+]", "[H-]"]} |
Using 5-(4-hydroxybenzyl)-3-tritylthiazolidine-2,4-dione, (3-([1,1'-biphenyl]-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-2-yl)methanol to produce 5-(4-((3-([1,1'-biphenyl]-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-2-yl)methoxy)benzyl)-3-tritylthiazolidine-2,4-dione, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["c1ccccc1"], "agent": ["CCCCP(CCCC)CCCC", "O=C(N=NC(=O)N1CCCCC1)N1CCCCC1"]} |
Using hexane-2,5-dione, 5-bromopyridin-2-amine to produce 5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC(=O)O", "C1CCCCC1"], "agent": ["C"]} |
Using 6-(4-amino-2-methoxyphenyl)-3-cyclohexyl-1-methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, 2-chloroethyl carbonochloridate to produce 3-(4-(3-cyclohexyl-1-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-3-methoxyphenyl)oxazolidin-2-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1", "CCN(CC)CC"], "agent": ["[Na+]", "O=C([O-])O"]} |
Using benzyl ((R)-1-((2R,3S)-1-(1,3-bis(4-methoxyphenyl)propan-2-yl)-2-((R)-1-((tert-butyldimethylsilyl)oxy)propan-2-yl)-4-oxoazetidin-3-yl)ethyl) carbonate to produce benzyl ((R)-1-((2R,3S)-1-(1,3-bis(4-methoxyphenyl)propan-2-yl)-2-((R)-1-hydroxypropan-2-yl)-4-oxoazetidin-3-yl)ethyl) carbonate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O", "CO"], "agent": ["Cl"]} |
Using 2-(4-chloro-2-methylphenoxy)acetic acid to produce 2-(4-chloro-2-methylphenoxy)acetate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["[K+]", "[OH-]"]} |
Using 2-((ethoxymethyl)amino)-N-((5-phenoxythiophen-2-yl)methyl)nicotinamide to produce 2-(methylamino)-N-((5-phenoxythiophen-2-yl)methyl)nicotinamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "CS(C)=O"], "agent": ["[Na+]", "[BH4-]"]} |
Using ethyl 3-((2,6-difluorophenyl)sulfonamido)-4-fluorobenzoate, 2-chloro-4-methylpyrimidine to produce N-(5-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["C[Si](C)(C)[N-][Si](C)(C)C", "[Li+]"]} |
Using 2,2,2-trichloroethan-1-ol, 3-(4-(2-((tert-butylsilyl)oxy)propan-2-yl)phenyl)-2-ethoxypropanoic acid to produce 2,2,2-trichloroethyl 3-(4-(2-((tert-butylsilyl)oxy)propan-2-yl)phenyl)-2-ethoxypropanoate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["ClCCl", "ClCCCl"], "agent": ["CN(C)c1ccncc1", "Cl"]} |
Using 3-((1H-benzo[d]imidazol-2-yl)((1-methylpiperidin-4-yl)oxy)methyl)benzaldehyde to produce (3-((1H-benzo[d]imidazol-2-yl)((1-methylpiperidin-4-yl)oxy)methyl)phenyl)methanol, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["[Na+]", "[BH4-]"]} |
Using ethyl 5-tosyl-4,5-dihydro-1H-pyrimido[5,4-b]indole-2-carboxylate to produce 5H-pyrimido[5,4-b]indole-2-carboxylic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["Cc1ccccc1C"], "agent": ["[C]", "[Pd]"]} |
Using 1-(3-(2-chloroethoxy)-5-((naphthalen-1-ylsulfonyl)methyl)-4-nitrophenyl)-4-methylpiperazine to produce 2-(2-chloroethoxy)-4-(4-methylpiperazin-1-yl)-6-((naphthalen-1-ylsulfonyl)methyl)aniline, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1", "CO"], "agent": ["[Pd]"]} |
Using 1-chloro-2,3-epoxypropane, 1-(3-(4-bromophenyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one to produce 1-(3-(4-bromophenyl)-1-(oxiran-2-ylmethyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O", "CN(C)C=O"], "agent": ["O=C([O-])[O-]", "[Cs+]"]} |
Using diisopropyl (2R,3S)-2-benzyl-3-hydroxysuccinate to produce (2R,3S)-2-benzyl-3-hydroxysuccinic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "C1CCOC1"], "agent": ["[K+]", "[OH-]"]} |
Using tert-butyl (R)-2-((tosyloxy)methyl)pyrrolidine-1-carboxylate, 4-(benzyloxy)phenol to produce tert-butyl 2-((4-(benzyloxy)phenoxy)methyl)pyrrolidine-1-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["[Na+]", "[H-]"]} |
Using methanesulfonyl chloride, 4-hydroxybenzenesulfonate to produce 4-((methylsulfonyl)oxy)benzenesulfonate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O"], "agent": ["[Cl-]", "[Na+]", "[OH-]"]} |
Using 2-(piperazin-1-yl)propan-1-ol, N-(3-(3,5-dimethoxyphenethyl)-1H-pyrazol-5-yl)-4-fluorobenzamide to produce N-(3-(3,5-dimethoxyphenethyl)-1H-pyrazol-5-yl)-4-(4-(1-hydroxypropan-2-yl)piperazin-1-yl)benzamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CS(C)=O", "CCN(C(C)C)C(C)C"], "agent": ["Cl"]} |
Using ethyl 1-(5-((tert-butoxycarbonyl)amino)-2,4-difluorophenyl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate, azide to produce ethyl 7-azido-1-(5-((tert-butoxycarbonyl)amino)-2,4-difluorophenyl)-8-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O", "CN(C)C=O"], "agent": ["[Na+]"]} |
Using 3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(2-(tritylthio)acetyl)phenyl)benzamide to produce 3-(2-cyanopropan-2-yl)-N-(3-(2-mercaptoacetyl)-4-methylphenyl)benzamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O=C(O)C(F)(F)F", "ClCCl"], "agent": ["CC[SiH](CC)CC"]} |
Using 5-chlorothiazolo[5,4-b]pyridine-2-thiol, thf to produce 5-chloro-2-(methylthio)thiazolo[5,4-b]pyridine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O", "CI"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using methyl 4-oxo-4-(2,3,4-trimethoxyphenyl)butanoate to produce 4-oxo-4-(2,3,4-trimethoxyphenyl)butanoic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "CO"], "agent": ["[Na+]", "[OH-]"]} |
Using benzoyl isothiocyanate, 4-chloro-3-methoxyaniline to produce 1-(4-chloro-3-methoxyphenyl)thiourea, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "C1CCOC1"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using (S)-7-((tert-butoxycarbonyl)amino)-1-oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, (S)-1-(L-histidyl)pyrrolidine-2-carboxamide to produce tert-butyl ((S)-3-(((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)carbamoyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl)carbamate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O", "CCN(CC)CC"], "agent": ["O=C1CCC(=O)N1O", "C(=NC1CCCCC1)=NC1CCCCC1"]} |
Using methyl 5-chloro-2-methyl-3-((tetrahydro-2H-pyran-4-yl)amino)benzoate, carbonate to produce methyl 5-chloro-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzoate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC#N", "CI"], "agent": ["[Cs+]"]} |
Using chloride, 2-(adamantan-1-yl)acetic acid to produce 2-(3-chloroadamantan-1-yl)acetic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["ClC(Cl)(Cl)Cl", "CC(C)(C)O"], "agent": ["O=S(=O)(O)O", "[Na+]"]} |
Using 2-(pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-amine, 4-(ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid to produce ethyl 1-methyl-5-((2-(pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-yl)carbamoyl)-1H-pyrazole-4-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1", "CCN(C(C)C)C(C)C"], "agent": ["CCCP(=O)=O"]} |
Using hexahydroindolizin-7(1H)-one, (3-bromophenyl)hydrazine to produce 8-bromo-2,3,5,10,11,11a-hexahydro-1H-indolizino[7,6-b]indole, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCO"], "agent": ["Cl"]} |
Using 1-bromo-4-(bromomethyl)benzene, 4-bromobut-1-ene to produce 1-bromo-4-(pent-4-en-1-yl)benzene, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["[Mg]", "Cl"]} |
Using methyl [1,2,3]thiadiazolo[5,4-b]pyridine-6-carboxylate to produce [1,2,3]thiadiazolo[5,4-b]pyridine-6-carboxylic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["[Na+]", "[OH-]"]} |
Using 3-(5-(3-(1-methyl-3-pentylureido)phenyl)pyrimidin-2-yl)acrylate to produce 3-(5-(3-(1-methyl-3-pentylureido)phenyl)pyrimidin-2-yl)acrylic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "C1CCOC1"], "agent": ["[Na+]", "[OH-]"]} |
Using 2-chloro-9-(methoxycarbonyl)-10-methylacridin-10-ium to produce methyl 2-chloro-10-methyl-9,10-dihydroacridine-9-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "CO"], "agent": ["[K+]", "[BH4-]", "O=S(=O)([O-])[O-]"]} |
Using 3-(4-fluorophenyl)-1-isopropyl-1H-indole-2-carbaldehyde, diethyl (2-(methoxy(methyl)amino)-2-oxoethyl)phosphonate to produce (E)-3-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-N-methoxy-N-methylacrylamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "C1CCOC1"], "agent": ["[Na+]", "[H-]"]} |
Using 1H-benzo[d][1,2,3]triazol-1-ol, (Z)-4-ethyl-5-((methylthio)(phenylimino)methyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid to produce methyl 2-((2-aminophenyl)carbamoyl)-N-phenyl-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carbimidothioate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O", "CCN(CC)CC"], "agent": ["CCN=C=NCCCN(C)C"]} |
Using 2-chloroacetamide, tert-butyl 4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate to produce tert-butyl 4-(2-carbamoylbenzofuran-5-yl)piperazine-1-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN1CCCC1=O"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using 2-methoxy-6-(4-nitrophenoxy)naphthalene to produce 4-((6-methoxynaphthalen-2-yl)oxy)aniline, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O"], "agent": ["[Pd]"]} |
Using tert-butyl (1-(2-(4-(benzyloxy)-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)carbamate to produce tert-butyl ((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)(1-(2-(4-hydroxy-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1", "CO"], "agent": ["[Pd]"]} |
Using ethyl 4-(((benzyloxy)carbonyl)amino)-2-((6-(bis(tert-butoxycarbonyl)amino)-5-methylpyridin-3-yl)methyl)-3-dihydrophosphoryl-3-hydroxy-5-methylhexanoate to produce 4-(((benzyloxy)carbonyl)amino)-2-((6-((tert-butoxycarbonyl)amino)-5-methylpyridin-3-yl)methyl)-3-dihydrophosphoryl-3-hydroxy-5-methylhexanoic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC#N", "CO"], "agent": ["[Li+]", "[OH-]"]} |
Using 1-iodo-3,3-dimethylbutane, 2-phenylpropanoic acid to produce 2,5,5-trimethyl-2-phenylhexanoic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1"], "agent": ["C[Si](C)(C)[N-][Si](C)(C)C", "[Li+]"]} |
Using 5-methoxy-2-methylaniline, 2-chloroacetyl chloride to produce 2-chloro-N-(5-methoxy-2-methylphenyl)acetamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["C1CCOC1", "CCN(C(C)C)C(C)C"], "agent": ["Cl"]} |
Using (2-azido-5-chlorophenyl)(phenyl)methanone, hydroxylamine to produce (2-azido-5-chlorophenyl)(phenyl)methanone oxime, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCO", "c1ccncc1"], "agent": ["Cl"]} |
Using butanone, 2-(1,2,2-trimethylbicyclo[3.1.0]hexan-3-yl)acetaldehyde to produce 3-methyl-5-(1,2,2-trimethylbicyclo[3.1.0]hexan-3-yl)pent-3-en-2-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "CO"], "agent": ["[K+]", "[OH-]"]} |
Using 2,5-dibromopyridine, (4-(benzyloxy)-3-fluorophenyl)boronic acid to produce 2-(4-(benzyloxy)-3-fluorophenyl)-5-bromopyridine, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCO", "Cc1ccccc1"], "agent": ["O=C([O-])[O-]", "[Na+]", "c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1"]} |
Using methyl 5-((1H-pyrrolo[2,3-b]pyridin-3-yl)methylene)-2-(cyclopropylamino)-4-oxo-4,5-dihydrofuran-3-carboxylate to produce 2-((1H-pyrrolo[2,3-b]pyridin-3-yl)methylene)-5-(cyclopropylamino)furan-3(2H)-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCO"], "agent": ["[K+]", "[OH-]"]} |
Using hydroxylamine, 2-(4-(2-(naphthalen-2-yloxy)ethoxy)phenyl)-2-oxoacetic acid to produce 2-(hydroxyimino)-2-(4-(2-(naphthalen-2-yloxy)ethoxy)phenyl)acetic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["[Na+]", "Cl", "[OH-]"]} |
Using ethyl 2-bromoacetate, 3-(3,4-dichlorobenzyl)quinazoline-2,4(1H,3H)-dione to produce ethyl 2-(3-(3,4-dichlorobenzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["[Na+]", "Cl", "[H-]"]} |
Using 5-(2,6-dibromo-4-nitro-3-(trifluoromethyl)phenoxy)-2-hydroxy-3-isopropylbenzaldehyde to produce 4-(2,6-dibromo-4-nitro-3-(trifluoromethyl)phenoxy)-2-isopropyl-6-methylphenol, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O=C(O)C(F)(F)F"], "agent": ["CC[SiH](CC)CC"]} |
Using benzoquinone, (2-ethoxy-2-oxoethyl)zinc(II) bromide to produce ethyl 2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCOC(C)=O", "C1CCOC1"], "agent": ["Cl"]} |
Using N'-((5-bromothiophen-2-yl)sulfonyl)-N,N-dimethylformimidamide, 3-mercaptopropane-1,2-diol to produce 5-((2,3-dihydroxypropyl)thio)thiophene-2-sulfonamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O", "O"], "agent": ["[Na+]", "[H-]"]} |
Using furo[3,2-c]pyridine-2-carbaldehyde to produce furo[3,2-c]pyridin-2-ylmethanol, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["[Na+]", "[BH4-]"]} |
Using 2-(2-(4-aminophenyl)-1-hydroxyethyl)benzoic acid to produce 2-(2-(4-(dibenzylamino)phenyl)-1-hydroxyethyl)benzoic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["[Pd]"]} |
Using tert-butyl (5-((4-(2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethoxy)phenyl)ethynyl)-2,2-dimethyl-1,3-dioxan-5-yl)carbamate to produce tert-butyl (5-(4-(2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethoxy)phenethyl)-2,2-dimethyl-1,3-dioxan-5-yl)carbamate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCO"], "agent": ["[Pd]"]} |
Using ethyl 3-(5-amino-4-cyano-3-(pyridin-3-yl)-1H-pyrazol-1-yl)propanoate to produce 5-oxo-2-(pyridin-3-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "C1CCOC1"], "agent": ["[Li]CCCC"]} |
Using 6-((5-(1-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)-1H-pyrazol-4-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)methyl)quinoline to produce 2-(4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)-1H-pyrazol-1-yl)ethan-1-ol, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "CO"], "agent": ["Cc1ccc(S(=O)(=O)O)cc1"]} |
Using 1-phenyl-2,3-dihydroquinolin-4(1H)-one, diethylcarbonate to produce ethyl 4-hydroxy-1-phenyl-1,2-dihydroquinoline-3-carboxylate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["c1ccccc1"], "agent": ["[Na+]", "[H-]"]} |
Using N'-acetylacetohydrazide, bis(2-chloroethyl)ether to produce 1,1'-(1,4,5-oxadiazepine-4,5-diyl)bis(ethan-1-one), please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC(C)O", "CS(C)=O"], "agent": ["O=C([O-])[O-]", "[K+]", "[OH-]"]} |
Using tert-butyl 4-(bromomethyl)-3-methoxybenzoate, N-(cyclopentylmethyl)-1-(2-methoxy-4-((phenylsulfonyl)carbamoyl)benzyl)-3-(3-morpholino-3-oxopropyl)-1H-indole-6-carboxamide to produce 4-((6-((cyclopentylmethyl)carbamoyl)-3-(3-morpholino-3-oxopropyl)-1H-indol-1-yl)methyl)-3-methoxybenzoic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "C1COCCN1"], "agent": ["CN(C)c1ccncc1", "Cl"]} |
Using 1-(trimethylsilyl)pyrrolidin-2-one, 1a,2,3,8b-tetrahydrobenzo[b]oxireno[2,3-d]oxepine to produce 1-((4R,5R)-4-hydroxy-2,3,4,5-tetrahydrobenzo[b]oxepin-5-yl)pyrrolidin-2-one, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O", "C1CCOC1"], "agent": ["[F-]", "CCCC[N+](CCCC)(CCCC)CCCC"]} |
Using N-(2-(((7-methoxybenzofuran-2-yl)methyl)amino)ethyl)adamantane-1-carboxamide to produce N-(2-(((7-methoxybenzofuran-2-yl)methyl)(methyl)amino)ethyl)adamantane-1-carboxamide, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CCO", "O"], "agent": ["Cl", "C=O", "[Pd]"]} |
Using iodomethane, ethyl 2-(3-(methoxymethoxy)phenyl)acetate to produce ethyl 2-(3-(methoxymethoxy)phenyl)propanoate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["[Na+]", "[H-]"]} |
Using 2-fluoro-5-(trifluoromethyl)benzonitrile, 2-nitroaniline to produce 2-((2-nitrophenyl)amino)-5-(trifluoromethyl)benzonitrile, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CN(C)C=O"], "agent": ["O=C([O-])[O-]", "[Cs+]", "Cl"]} |
Using 1-ethyl-5-(2-(methylsulfonyl)ethyl)-1H-pyrazole-3-carboxamide to produce 1-ethyl-5-(2-(methylsulfonyl)ethyl)-1H-pyrazole-3-carbonitrile, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["O=P(Cl)(Cl)Cl"], "agent": ["[NH4+]", "[OH-]"]} |
Using benzo[1,2-d:4,5-d']bis([1,3]dithiole)-2,2,6,6-tetrayltetrakis(methylene) tetraacetate to produce benzo[1,2-d:4,5-d']bis([1,3]dithiole)-2,2,6,6-tetrayltetramethanol, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CO"], "agent": ["O=C([O-])[O-]", "[K+]"]} |
Using 2-((9-(3-methoxy-4-((5-methyl-2-phenyloxazol-4-yl)methoxy)benzyl)-9H-carbazol-4-yl)oxy)-2-methylpropanoic acid to produce 2-((9-(3-methoxy-4-((5-methyl-2-phenyloxazol-4-yl)methoxy)benzyl)-9H-carbazol-4-yl)oxy)-2-methylpropanoate, please predict the condition, including solvent and agent in SMILES notation in json format like:
```JSON
{
"solvent": [
"CCN(CC)CC",
"CCOC(C)=O"
],
"agent": [
"On1nnc2ccccc21",
"C(=NC1CCCCC1)=NC1CCCCC1",
"Cl"
]
}
```
| {"solvent": ["CC(C)O"], "agent": ["[Na+]", "[OH-]"]} |
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