collij22/adesplit · Datasets at Hugging Face

text stringlengths 7 573	label int64 0 1
Phenytoin, verapamil, and acetazolamide were ineffective, but tocainide yielded good results.	0
Indeed, the reported annual number of imported malaria cases increased to not less than 100.	0
rEpo was administered by i.v. injection three times a week for at least four weeks.	0
Exposures to 4-hydroxycyclophosphamide, the combination of thiotepa/tepa and carboplatin were 94%, 117% and 71% higher than the median respective exposures in a non-obese population of patients ( n=24) receiving similar doses.	0
When patch test are performed with several drugs of the same family, results seem to indicate an absence of cross-sensitivity, but in several patients, oral provocation test were needed because patch test gave no conclusive information.	0
We describe the first documented case of azathioprine-induced severe myelosuppression due to thiopurine methyltransferase deficiency in autoimmune liver disease.	1
Mycophenolate mofetil-induced neutropenia in liver transplantation.	1
Pathogenesis of methotrexate-induced papular eruption in psoriasis may involve immune mechanisms other than those of methotrexate-induced cutaneous vasculitis in collagen vascular disease.	1
The patient developed unusually severe hematological toxicity to chemotherapy as compared to nonsmall cell lung cancer patients without the GD defect.	0
Only one report links phenylpropanolamine consumption to an intracerebral hemorrhage in a patient with an AVM.	1
ADH hypersecretion in relation to plasma osmolality was reversed by mizoribin withdrawal, suggesting that bredinin might adversely induce SIADH.	1
We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib.	1
However, cyclosporine dependency is associated with the risk of nephrotoxicity.	1
INTRODUCTION: We describe the neurointensive care (NIC) management of a patient with severe cerebral swelling and raised intracranial pressure (ICP) after severe sodium valproic acid (VPA) intoxication.	1
An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate.	1
Hemorrhagic cystitis is a significant toxic effect of cyclophosphamide therapy.	1
Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.	1
The patient was discharged with a diagnosis of HCV-related active chronic hepatitis, skin porphyria, and type 2 diabetes.	0
Postmortem examination revealed only minimal neoplastic infiltration of the meninges.	0
The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay.	1
The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.	1
Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.	1
Fatal interstitial lung disease after erlotinib administration in a patient with radiation fibrosis.	1
With either discontinuation or decreased dosage of the drug the symptoms disappeared and did not recur.	0
Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage.	1
Herein, we present a patient with severe and prolonged hypoglycemia after long-acting octreotide treatment.	1
He had been receiving L-thyroxine therapy following mitral valve surgery.	0
Two months later, hyponatremia was diagnosed, most likely syndrome of inappropriate antidiuretic hormone secretion.	0
The majority of the induced lesions is in the distal ileum, sigmoid colon, or rectum.	0
OBJECTIVE: To report the finding of squamous metaplasia within endometrial glands occurring as a result of progestin therapy of hyperplasia.	1
We describe 3 AS patients treated with etanercept for active AS who developed new onset of CD while AS related symptoms responded well to etanercept.	1
Two cases of malignant hyperthermia (MH) are presented.	0
Paroxysmal supraventricular tachycardia during treatment with cisplatin and etoposide combination.	1
Three patients were treated with aminocaproic acid for medically uncontrolled hyphemas that developed after cataract extractions.	0
OBJECTIVE: To describe onset of syndrome of inappropriate antidiuretic hormone (SIADH) associated with vinorelbine therapy for advanced breast cancer.	1
Moreover, in the appropriate clinical setting, even in the absence of pulmonary signs or symptoms, diffuse pulmonary uptake of labeled leukocytes should alert the physician to the possibility of drug-induced pneumonitis.	0
Posttransplant lymphoproliferative disorder of the nasopharynx.	0
We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.	1
The eighth exhibited concentric constriction.	0
Pathology evaluation of a specimen revealed a high-grade osteoblastic osteosarcoma.	0
The cancer developed on a very thin endometrium and transvaginal ultrasonography failed to detect it.	0
A patient developed restless legs symptoms paralleling the course of interferon-alpha (IFN alpha) therapy for chronic hepatitis C.	1
Ulcer became worse after tobramycin and gentamycin treatment for 2 days.	1
Removal of a well-fixed metal-metal hip resurfacing acetabular component.	0
MR detected brain abnormalities in four patients, three of whom had concomitant neurologic dysfunction.	0
Bortezomib-induced paralytic ileus is a potential gastrointestinal side effect of this first-in-class anticancer proteasome inhibitor.	1
The use of cyclosporin has been associated with the development of cholelithiasis in transplant recipients.	1
Multiple keratoacanthomas after megavoltage radiation therapy.	0
A patient with ocular syphilis is presented.	0
Possible mechanisms by which clonidine decreases spasticity are described, probable mechanisms of induced bradycardia are reviewed, and specific treatment recommendations for the use of clonidine in spinal cord injured patients are presented.	1
Systemic vasculitis complicating hairy cell leukaemia treatment with cladribine.	1
One patient had MRI T2 abnormalities compatible with cyclosporin neurotoxicity.	1
The mortality rate has been estimated at about 10%.	0
BACKGROUND: Fluticasone propionate was introduced in 1993 in the UK as a potentially safer inhaled corticosteroid than those already in use.	0
There is yet no explanation for the occurrence of hallucinations or psychosis.	0
Gastric tumor, endometrial carcinoma and cervical adenocarcinoma in situ were detected after treatment with tamoxifen for breast cancer.	1
An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.	1
More than 50 cases of tuberculous peritonitis complicating CAPD that have been reported in the English-language literature since the initial case was reported in 1980 are reviewed.	0
OBJECTIVE: To report 2 cases of nonconvulsive status epilepticus (NCSE) following infusion of ifosfamide.	1
Primary Central Nervous System Lymphoma (PCNSL) was seen in 2% of the liver, and 2% of the heart recipients.	0
Warfarin-associated thoracic aortic dissection in an elderly woman.	1
Ventricular fibrillation during transesophageal atrial pacing in an infant with Wolff-Parkinson-White syndrome.	0
Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed.	1
We report the case of a 27-year-old Indian woman who developed maculopapular rash and angioedema secondary to carbamazepine administration.	1
RESULTS: Both patients experienced a previously unreported side effect--falling backward--associated with bupropion use.	1
A woman with a 20-year history of acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs, developed a B-cell lymphoma of the lip following 4 1/2 years of treatment with razoxane.	1
We report a case of a recurrent Listeria monocytogenes bacteraemia in a 46 year-old liver transplant patient.	0
Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.	1
The nephrotic syndrome was treated successfully with prednisolone.	0
Acute psychosis associated with levetiracetam.	1
This paper reports an autopsy case of a 78-year-old male with multiple nodules in the liver developed after long-termed administration of phosphate diethylstilbestrol (PDES) for prostatic cancer.	1
Electron microscopy showed diffuse effacement of the glomerular epithelial foot processes, leading to a diagnosis of minimal change nephrotic syndrome with interstitial nephritis.	0
Flurbiprofen-associated acute tubulointerstitial nephritis.	1
We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding.	1
Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide.	1
We report a case with chronic hepatitis C (CHC) who developed sarcoidosis after the treatment by interferon alpha and ribavirin.	1
In the same period, healthcare professionals submitted 10 635 reports, concerning 16 722 ADRs.	0
Serial hemograms were characterized by persistent thrombocytosis (platelet count, 577,000 to 1,200,000/microl) with abnormal platelet morphology.	0
Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.	1
Thiopurine methyltransferase deficiency occurs at a frequency of one in 300 and is associated with profound myelosuppression after a short course of azathioprine.	1
The neonate weighed 884 g and died 1 h after birth.	0
We postulate that the patient's hearing loss was the result of ketoralac's direct and indirect ototoxic effects that were potentiated as a result of her underlying illness and medications.	0
After 6 weeks of oral Sildenafil treatment, her serum albumin and the fecal alpha-1-antitrypsin levels normalized, and her exercise tolerance had increased.	0
DISCUSSION: Both cases met Stembach's criteria for serotonin syndrome and had serious extrapyramidal movement disorders.	0
When the skin lesions had improved, phlebitis was found at the injection site of the peripheral vein catheter.	0
In the second case, five cardiac arrests due to ventricular tachycardia and fibrillation occurred during several hours after beginning a trial of bretylium maintenance therapy for complex ventricular ectopy.	1
PURPOSE: Platinum-based therapy is the cornerstone of ovarian cancer treatment.	0
We report a cytomegalovirus (CMV) IgG +ve 56-year-old patient who underwent autologous rescue with CD34(+) selected peripheral blood stem cells as part of consolidation therapy for multiple myeloma and subsequently developed CMV colitis.	0
Toxic epidermal necrolysis resulted after 19 days of treatment with 5-fluorocytosine and amphotericin B.	1
CONCLUSIONS: With increasing clinical use of terlipressin and an increasing incidence of obesity and non-alcoholic fatty liver disease-related cirrhosis, the incidence of these serious complications is likely to rise.	0
Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.	1
Hemorrhage from a falx meningioma after internal use of low-dose aspirin.	1
OBJECTIVES: The authors described a case of Hashimoto's disease during interferon-alpha (IFN-alpha) treatment for chronic viral C hepatitis in a patient with the specific genetic susceptibility associated with the thyroid disease.	1
After a six-week course of low-dose cyclosporine A, she developed a severe but reversible loss of glomerular filtration rate and effective renal plasma flow despite of low cyclosporine A plasma levels.	1
Two cases of long term dopamine D2 receptor blockade after depot neuroleptics.	0
Woman interrupted gestation, by labour induction.	0
OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.	1
After the addition of citalopram, a desmethylclomipramine plasma level increase and an 8-hydroacy-desmethylclomipramine plasma level decrease were observed.	1
Although other nitrites induce methemoglobinemia, exposure to methyl nitrite during phenylpropanolamine production appears to be a new cause of occupational methemoglobinemia.	1
Data obtained from animal studies support the established hypothesis that lactate is distributed like other weak organic acids at steady-state; hence, alkalemia should favor a shift of lactate from the intracellular fluid (ICF) to the extracellular fluid (ECF).	0

Phenytoin, verapamil, and acetazolamide were ineffective, but tocainide yielded good results.

0

Indeed, the reported annual number of imported malaria cases increased to not less than 100.

0

rEpo was administered by i.v. injection three times a week for at least four weeks.

0

Exposures to 4-hydroxycyclophosphamide, the combination of thiotepa/tepa and carboplatin were 94%, 117% and 71% higher than the median respective exposures in a non-obese population of patients ( n=24) receiving similar doses.

0

When patch test are performed with several drugs of the same family, results seem to indicate an absence of cross-sensitivity, but in several patients, oral provocation test were needed because patch test gave no conclusive information.

0

We describe the first documented case of azathioprine-induced severe myelosuppression due to thiopurine methyltransferase deficiency in autoimmune liver disease.

1

Mycophenolate mofetil-induced neutropenia in liver transplantation.

1

Pathogenesis of methotrexate-induced papular eruption in psoriasis may involve immune mechanisms other than those of methotrexate-induced cutaneous vasculitis in collagen vascular disease.

1

The patient developed unusually severe hematological toxicity to chemotherapy as compared to nonsmall cell lung cancer patients without the GD defect.

0

Only one report links phenylpropanolamine consumption to an intracerebral hemorrhage in a patient with an AVM.

1

ADH hypersecretion in relation to plasma osmolality was reversed by mizoribin withdrawal, suggesting that bredinin might adversely induce SIADH.

1

We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib.

1

However, cyclosporine dependency is associated with the risk of nephrotoxicity.

1

INTRODUCTION: We describe the neurointensive care (NIC) management of a patient with severe cerebral swelling and raised intracranial pressure (ICP) after severe sodium valproic acid (VPA) intoxication.

1

An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate.

1

Hemorrhagic cystitis is a significant toxic effect of cyclophosphamide therapy.

1

Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.

1

The patient was discharged with a diagnosis of HCV-related active chronic hepatitis, skin porphyria, and type 2 diabetes.

0

Postmortem examination revealed only minimal neoplastic infiltration of the meninges.

0

The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay.

1

The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.

1

Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.

1

Fatal interstitial lung disease after erlotinib administration in a patient with radiation fibrosis.

1

With either discontinuation or decreased dosage of the drug the symptoms disappeared and did not recur.

0

Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage.

1

Herein, we present a patient with severe and prolonged hypoglycemia after long-acting octreotide treatment.

1

He had been receiving L-thyroxine therapy following mitral valve surgery.

0

Two months later, hyponatremia was diagnosed, most likely syndrome of inappropriate antidiuretic hormone secretion.

0

The majority of the induced lesions is in the distal ileum, sigmoid colon, or rectum.

0

OBJECTIVE: To report the finding of squamous metaplasia within endometrial glands occurring as a result of progestin therapy of hyperplasia.

1

We describe 3 AS patients treated with etanercept for active AS who developed new onset of CD while AS related symptoms responded well to etanercept.

1

Two cases of malignant hyperthermia (MH) are presented.

0

Paroxysmal supraventricular tachycardia during treatment with cisplatin and etoposide combination.

1

Three patients were treated with aminocaproic acid for medically uncontrolled hyphemas that developed after cataract extractions.

0

OBJECTIVE: To describe onset of syndrome of inappropriate antidiuretic hormone (SIADH) associated with vinorelbine therapy for advanced breast cancer.

1

Moreover, in the appropriate clinical setting, even in the absence of pulmonary signs or symptoms, diffuse pulmonary uptake of labeled leukocytes should alert the physician to the possibility of drug-induced pneumonitis.

0

Posttransplant lymphoproliferative disorder of the nasopharynx.

0

We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.

1

The eighth exhibited concentric constriction.

0

Pathology evaluation of a specimen revealed a high-grade osteoblastic osteosarcoma.

0

The cancer developed on a very thin endometrium and transvaginal ultrasonography failed to detect it.

0

A patient developed restless legs symptoms paralleling the course of interferon-alpha (IFN alpha) therapy for chronic hepatitis C.

1

Ulcer became worse after tobramycin and gentamycin treatment for 2 days.

1

Removal of a well-fixed metal-metal hip resurfacing acetabular component.

0

MR detected brain abnormalities in four patients, three of whom had concomitant neurologic dysfunction.

0

Bortezomib-induced paralytic ileus is a potential gastrointestinal side effect of this first-in-class anticancer proteasome inhibitor.

1

The use of cyclosporin has been associated with the development of cholelithiasis in transplant recipients.

1

Multiple keratoacanthomas after megavoltage radiation therapy.

0

A patient with ocular syphilis is presented.

0

Possible mechanisms by which clonidine decreases spasticity are described, probable mechanisms of induced bradycardia are reviewed, and specific treatment recommendations for the use of clonidine in spinal cord injured patients are presented.

1

Systemic vasculitis complicating hairy cell leukaemia treatment with cladribine.

1

One patient had MRI T2 abnormalities compatible with cyclosporin neurotoxicity.

1

The mortality rate has been estimated at about 10%.

0

BACKGROUND: Fluticasone propionate was introduced in 1993 in the UK as a potentially safer inhaled corticosteroid than those already in use.

0

There is yet no explanation for the occurrence of hallucinations or psychosis.

0

Gastric tumor, endometrial carcinoma and cervical adenocarcinoma in situ were detected after treatment with tamoxifen for breast cancer.

1

An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.

1

More than 50 cases of tuberculous peritonitis complicating CAPD that have been reported in the English-language literature since the initial case was reported in 1980 are reviewed.

0

OBJECTIVE: To report 2 cases of nonconvulsive status epilepticus (NCSE) following infusion of ifosfamide.

1

Primary Central Nervous System Lymphoma (PCNSL) was seen in 2% of the liver, and 2% of the heart recipients.

0

Warfarin-associated thoracic aortic dissection in an elderly woman.

1

Ventricular fibrillation during transesophageal atrial pacing in an infant with Wolff-Parkinson-White syndrome.

0

Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed.

1

We report the case of a 27-year-old Indian woman who developed maculopapular rash and angioedema secondary to carbamazepine administration.

1

RESULTS: Both patients experienced a previously unreported side effect--falling backward--associated with bupropion use.

1

A woman with a 20-year history of acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs, developed a B-cell lymphoma of the lip following 4 1/2 years of treatment with razoxane.

1

We report a case of a recurrent Listeria monocytogenes bacteraemia in a 46 year-old liver transplant patient.

0

Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.

1

The nephrotic syndrome was treated successfully with prednisolone.

0

Acute psychosis associated with levetiracetam.

1

This paper reports an autopsy case of a 78-year-old male with multiple nodules in the liver developed after long-termed administration of phosphate diethylstilbestrol (PDES) for prostatic cancer.

1

Electron microscopy showed diffuse effacement of the glomerular epithelial foot processes, leading to a diagnosis of minimal change nephrotic syndrome with interstitial nephritis.

0

Flurbiprofen-associated acute tubulointerstitial nephritis.

1

We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding.

1

Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide.

1

We report a case with chronic hepatitis C (CHC) who developed sarcoidosis after the treatment by interferon alpha and ribavirin.

1

In the same period, healthcare professionals submitted 10 635 reports, concerning 16 722 ADRs.

0

Serial hemograms were characterized by persistent thrombocytosis (platelet count, 577,000 to 1,200,000/microl) with abnormal platelet morphology.

0

Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.

1

Thiopurine methyltransferase deficiency occurs at a frequency of one in 300 and is associated with profound myelosuppression after a short course of azathioprine.

1

The neonate weighed 884 g and died 1 h after birth.

0

We postulate that the patient's hearing loss was the result of ketoralac's direct and indirect ototoxic effects that were potentiated as a result of her underlying illness and medications.

0

After 6 weeks of oral Sildenafil treatment, her serum albumin and the fecal alpha-1-antitrypsin levels normalized, and her exercise tolerance had increased.

0

DISCUSSION: Both cases met Stembach's criteria for serotonin syndrome and had serious extrapyramidal movement disorders.

0

When the skin lesions had improved, phlebitis was found at the injection site of the peripheral vein catheter.

0

In the second case, five cardiac arrests due to ventricular tachycardia and fibrillation occurred during several hours after beginning a trial of bretylium maintenance therapy for complex ventricular ectopy.

1

PURPOSE: Platinum-based therapy is the cornerstone of ovarian cancer treatment.

0

We report a cytomegalovirus (CMV) IgG +ve 56-year-old patient who underwent autologous rescue with CD34(+) selected peripheral blood stem cells as part of consolidation therapy for multiple myeloma and subsequently developed CMV colitis.

0

Toxic epidermal necrolysis resulted after 19 days of treatment with 5-fluorocytosine and amphotericin B.

1

CONCLUSIONS: With increasing clinical use of terlipressin and an increasing incidence of obesity and non-alcoholic fatty liver disease-related cirrhosis, the incidence of these serious complications is likely to rise.

0

Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.

1

Hemorrhage from a falx meningioma after internal use of low-dose aspirin.

1

OBJECTIVES: The authors described a case of Hashimoto's disease during interferon-alpha (IFN-alpha) treatment for chronic viral C hepatitis in a patient with the specific genetic susceptibility associated with the thyroid disease.

1

After a six-week course of low-dose cyclosporine A, she developed a severe but reversible loss of glomerular filtration rate and effective renal plasma flow despite of low cyclosporine A plasma levels.

1

Two cases of long term dopamine D2 receptor blockade after depot neuroleptics.

0

Woman interrupted gestation, by labour induction.

0

OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.

1

After the addition of citalopram, a desmethylclomipramine plasma level increase and an 8-hydroacy-desmethylclomipramine plasma level decrease were observed.

1

Although other nitrites induce methemoglobinemia, exposure to methyl nitrite during phenylpropanolamine production appears to be a new cause of occupational methemoglobinemia.

1

Data obtained from animal studies support the established hypothesis that lactate is distributed like other weak organic acids at steady-state; hence, alkalemia should favor a shift of lactate from the intracellular fluid (ICF) to the extracellular fluid (ECF).

0