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DS.d1450 | 18832097 | [
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"In the LNCaP prostate cancer cell line, induction of apoptosis and caspase-3/7 activities by staurosporine (STS) abolished ((3)H) 1,25-dihydroxy vitamin D (3) binding and VDR protein, suggesting that the VDR may be targeted for inactivation by caspases during apoptosis."
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}
] | [] | [] | [] |
DS.d1451 | 18832102 | [
{
"id": "DS.d1451.s0",
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"text": [
"The use of lipoproteins as a substrate for progesterone synthesis remains unclear, and the expression of lipoprotein receptors (very-low-density lipoprotein receptor (VLDLR), low-density lipoprotein receptor (LDLR), and scavenger receptor-BI (SR-BI 12 h) has not been characterized."
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}
] | [] | [] | [] |
DS.d1452 | 18832185 | [
{
"id": "DS.d1452.s0",
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"id": "DS.d1452.s1",
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"As this effect might be related to deregulation of connexin 43 (Cx43) synthesis, trafficking, or degradation, we investigated the impact of PCB 153 on these events."
],
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126,
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]
},
{
"id": "DS.d1452.s2",
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"Inhibition of either proteasomes or lysosomes with their specific inhibitors largely restored total Cx43 protein levels, thus suggesting that both proteasomes and lysosomes may participate in the PCB 153-enhanced Cx43 internalization and degradation."
],
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291,
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},
{
"id": "DS.d1452.s3",
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"Finally, PCB 153 also interfered with restoration of gap junction plaques following the inhibition of Cx43 transport to plasma membrane."
],
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},
{
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"Taken together, multiple modes of action seem to contribute to downregulation of Cx43 in PCB 153-treated rat liver epithelial cells."
],
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] | [] | [] | [
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},
{
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},
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{
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}
] |
DS.d1453 | 18832295 | [
{
"id": "DS.d1453.s0",
"type": "",
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"Vildagliptin demonstrates potent inhibition of DPP-4 activity with excellent tolerability at doses of up to and including 200 mg qd."
],
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0,
132
]
]
}
] | [
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},
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],
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]
}
] | [] | [] | [
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}
] |
DS.d1454 | 18832330 | [
{
"id": "DS.d1454.s0",
"type": "",
"text": [
"The accelerated rate of kindling was partially repressed by inhibiting N-methyl-D-aspartic acid receptor (NMDAR) with MK-801 or mGluR5 receptor with 2-methyl-6-(phenylethynyl)-pyridine (MPEP)."
],
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]
]
}
] | [
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]
},
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] |
DS.d1455 | 18832453 | [
{
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DS.d1457 | 18832476 | [
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] | [] | [] | [] |
DS.d1458 | 18832480 | [
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DS.d1459 | 18832589 | [
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DS.d1460 | 18832593 | [
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DS.d1461 | 18832596 | [
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DS.d1462 | 18832659 | [
{
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] |
DS.d1463 | 18832772 | [
{
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DS.d1464 | 18832826 | [
{
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}
] | [] | [] | [] |
DS.d1465 | 18834674 | [
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DS.d1466 | 18834690 | [
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DS.d1467 | 18834707 | [
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DS.d1468 | 18834868 | [
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DS.d1469 | 18834871 | [
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DS.d1470 | 18834900 | [
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DS.d1471 | 18834946 | [
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] |
DS.d1472 | 18834950 | [
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] |
DS.d1473 | 18834958 | [
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DS.d1481 | 18835362 | [
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DS.d1482 | 18835442 | [
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DS.d1483 | 18835585 | [
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DS.d1484 | 18835652 | [
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DS.d1485 | 18835662 | [
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] | [] | [] | [] |
DS.d1486 | 18835763 | [
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DS.d1488 | 18835830 | [
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] | [] | [] | [] |
DS.d1489 | 18835831 | [
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DS.d1490 | 18835926 | [
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] | [] | [] | [] |
DS.d1491 | 18835976 | [
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DS.d1492 | 18835979 | [
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DS.d1495 | 18836137 | [
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DS.d1496 | 18836482 | [
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DS.d1497 | 18836681 | [
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DS.d1498 | 18836710 | [
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DS.d1499 | 18836740 | [
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DS.d1500 | 18836843 | [
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DS.d1501 | 18836851 | [
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DS.d1503 | 18837008 | [
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DS.d1510 | 18838089 | [
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DS.d1511 | 18838102 | [
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DS.d1512 | 18838266 | [
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DS.d1513 | 18838482 | [
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DS.d1514 | 18838483 | [
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DS.d1515 | 18838503 | [
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DS.d1516 | 18838506 | [
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] | [] | [] | [
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] |
DS.d1517 | 18838523 | [
{
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] |
DS.d1518 | 18838739 | [
{
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}
] | [] | [] | [] |
DS.d1519 | 18839053 | [
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] | [] | [] | [] |
DS.d1521 | 18839068 | [
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] | [
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] | [] | [] | [
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] |
DS.d1522 | 18839150 | [
{
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},
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482,
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] | [
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{
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}
] | [] | [] | [
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] |
DS.d1523 | 18839155 | [
{
"id": "DS.d1523.s0",
"type": "",
"text": [
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],
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}
] | [
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DS.d1524 | 18839173 | [
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DS.d1525 | 18839216 | [
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DS.d1526 | 18839315 | [
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DS.d1527 | 18839328 | [
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DS.d1528 | 18839335 | [
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DS.d1529 | 18839360 | [
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DS.d1530 | 18839361 | [
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DS.d1531 | 18839419 | [
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DS.d1532 | 18840097 | [
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DS.d1533 | 18840413 | [
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DS.d1534 | 18840446 | [
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DS.d1535 | 18840462 | [
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DS.d1536 | 18840470 | [
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DS.d1539 | 18840501 | [
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DS.d1540 | 18840514 | [
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DS.d1541 | 18840516 | [
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DS.d1542 | 18840548 | [
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DS.d1543 | 18840610 | [
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235,
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] | [
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DS.d1544 | 18840670 | [
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DS.d1548 | 18840765 | [
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] | [] | [] | [] |
DS.d1549 | 18840783 | [
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DS.d1550 | 18840785 | [
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],
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215,
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