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Agentic Health, Inc. 3

https://www.semanticscholar.org/paper/99a6c3a6fd407307fd0c2a4b675902ac3ef18e3e

Correction: The Importance of Nutrigenetics and Microbiota in Personalized Medicine: From Phenotype to Genotype

Cureus

87c855fc-c59a-4443-832a-e5b1ca14b9f3

Correction: The Importance of Nutrigenetics and Microbiota in Personalized Medicine: From Phenotype to Genotype .

https://www.semanticscholar.org/paper/dd9d8477b00b19b5474ba97e008f7f33ef6244bf

Possible acute rejection associated with the use of the new anti-hepatitis C virus medications

Avicenna Journal of Medicine

bb61e75c-9a23-408d-b354-aee8d192cb8f

Possible acute rejection associated with the use of the new anti-hepatitis C virus medications Abstract Hepatitis C virus infection is associated with increased morbidity and mortality. It remains a major challenge for management and treatment, especially in patients with renal transplant. The new directacting antiviral agents gave big hopes to both clinicians and patients that they can overcome this challenge without major side effects. Studies recently have supported this claim; however, they are still few, limited, and may give false hopes. In the following case report, we present a case, supported by histological evidence about a possible acute rejection of kidney transplant after treatment with these new medications. This case is limited by the absence of donorspecific antibodies. This report is aimed to increase awareness about the urgent need for further studies.

https://www.semanticscholar.org/paper/0b9b9314a74dd1ed822c3a4c9e4df2df5447f888

Multi-drug resistant Pseudomonas aeruginosa keratitis and its effective treatment with topical colistimethate

Indian Journal of Ophthalmology

2bbc1e45-4074-471d-b003-2c8f5a99cdb0

Multi-drug resistant Pseudomonas aeruginosa keratitis and its effective treatment with topical colistimethate The purpose was to evaluate the clinical outcome in multi-drug resistant Pseudomonas aeruginosa (MDR-PA) bacterial keratitis and report the successful use of an alternative antibiotic, topical colistimethate in some of them. The medical records of 12 culture-proven MDR-PA keratitis patients, all exhibiting in vitro resistance by Kirby–Bauer disc diffusion method to ≥ three classes of routinely used topical antibiotics were reviewed. Eight patients were treated with 0.3% ciprofloxacin or ofloxacin, 1 patient with 5% imipenem/cilastatin and 3 patients with 1.6% colistimethate. The outcomes in 8 eyes treated with only fluoroquinolones were evisceration in 4 eyes, therapeutic corneal graft in 1 eye, phthisis bulbi in 1 eye, and no improvement in 2 eyes. The eye treated with imipenem/cilastin required a therapeutic corneal graft. All the three eyes treated with 1.6% colistimethate healed. Colistimethate may prove to be an effective alternative antibiotic in the treatment of MDR-PA keratitis.

https://www.semanticscholar.org/paper/843e81ca645766d6dc79123da2ccfa383ecc2b88

Changes in Radiologia Brasileira for 2015

Radiologia Brasileira

a400c3b0-f84c-49ff-9983-2e2ae4283061

Changes in Radiologia Brasileira for 2015 Radiol Bras. 2015 Jan/Fev;48(1):V The year has begun with encouraging news about the indexing of our journal. PubMed Central has approved the scientific merit of Radiologia Brasileira, opening the way to the final indexing in PubMed and later in ISI. The journal indexing in internationally recognized databases has been a top priority of the editors and members of the current and recent boards of directors of Colégio Brasileiro de Radiologia e Diagnóstico por Imagem. Such an objective has been shared with practically all the most important national and international medical journals. Researchers in the field of Radiology, particularly those participating in stricto sensu post-graduation programs evaluated by Capes, benefit greatly from such advances in the journal qualifying, not only with the evaluation of the programs which they belong to, but also with their personal evaluation as they apply for research scholarships to funding bodies. As a counterpart, the community may contribute to the development of this process: the only way up to ranking, improving the journal impact is that it be increasingly cited in our scientific papers published by other indexed journals. This is the way for the journal to get solid and consistent recognition in the international scientific scenario. Also, a range of measures were required for the journal to comply with international models. One of the most recent measures is the end of the case reports. Most of American, European and Asian journals do not publish case reports anymore, opening space for publication of more elaborate articles considered as more relevant, such as original articles and review articles. However, the reported cases are not devoid of value: many readers appreciate them and benefit from the information provided by case reports. In an attempt to not completely deprive the read-

https://www.semanticscholar.org/paper/628f8f5392b05d60b16258aad7bf5c86b00eb0b8

Correction: Trypanosoma cruzi: Role of δ-Amastin on Extracellular Amastigote Cell Invasion and Differentiation

PLoS ONE

0aed7a40-85f3-4c66-9e1b-c1556c57001b

Correction: Trypanosoma cruzi: Role of δ-Amastin on Extracellular Amastigote Cell Invasion and Differentiation There were errors in the legend of Supporting Information Figure S2. The correct text of that legend is available below. Figure S2 Specificity controls on western blots. A: anti-GST: 1) 10 µg of recombinant GST- δ-AmastinH; 2) 10 µg of GST. B: anti-GFP: 1) Total extract of epimastigote of G_pTREX-Amastin-GFP; 2: Total extract of epimastigote of G_pTREX-GFP; 3) Total extract of WT G strain epimastigote. C: anti- GST- δ-AmastinH: 1) 10 µg of recombinant GST- δ-AmastinH; 2) 10 µg of GST. D: Left Panel: anti- GST-δ-AmastinH: 1) 10 µg, GST; 2) 4 µg of recombinant GST-δ-AmastinH; 3) Total extract of WT EA of CL strain; 4) Total extract of WT epimastigotes of CL strain; 5) Total extract of WT EA of G strain; 6) Total extract of WT epimastigote of G strain. Right Panel: Coomassie loading control of D.

https://www.semanticscholar.org/paper/22644044b805b3395d88ef7709a1d0d7430b93ee

Erratum to “Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells” [Biomol. Ther. 22 (2014) 355–362]

Biomolecules & Therapeutics

ecec6464-e573-4ad6-a9d4-645c0607840f

Erratum to “Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells” .

https://www.semanticscholar.org/paper/fe6a1852768ffc2b07d2bcd01908c3417b4420e8

The Book World of Medicine and Science

The Hospital

965d752e-3d99-47a6-bf0f-de96ba26b1f3

The Book World of Medicine and Science Medical Partnerships, Transfers, and Assist as tsiiips, by William Barnard, M.A., LL.B., and G. Bertram Stocker. (London : Stevens and Sons. 1895. Pp. 249. Price 10s. 6d.) Simple as it may seem to take a partner, to transfer a practice, or to engage an assistant, it is certain that in each of these proceedings there are many pitfalls, and it is impossible to read this very useful handbook without seeing the importance of securing good legal advice when any such matters are in question. Even in the case of those, however, who would never think of moving without the assistance of a lawyer, the volume before us will be found of great assistance whenever such an event has to be discussed; for a considera-

https://www.semanticscholar.org/paper/bf4be3da37cba6726a8d259a2112550fa774eae4

A Historical Perspective on Commerce and the Spread of Disease

Journal of Microbiology & Biology Education

8f3490ca-f5fd-4c5e-a984-98f685d7f164

A Historical Perspective on Commerce and the Spread of Disease Review of: Contagion: How Commerce Has Spread Disease; Mark Harrison; (2012). Yale University Press, New Haven, CT. Hardcover, 376 pages.

https://www.semanticscholar.org/paper/b85cae00084a7a5961d558a7d82379c2dbd7788b

Trends of Surgical Service Utilization for Lumbar Spinal Stenosis in South Korea: A 10-Year (2010–2019) Cross-Sectional Analysis of the Health Insurance Review and Assessment Service—National Patient Sample Data

Medicina

1f732346-014b-468b-af67-371e4fd031b4

Trends of Surgical Service Utilization for Lumbar Spinal Stenosis in South Korea: A 10-Year (2010–2019) Cross-Sectional Analysis of the Health Insurance Review and Assessment Service—National Patient Sample Data Background and Objectives: This retrospective, cross-sectional, and descriptive study used claims data from the Korean Health Insurance Review and Assessment Service (HIRA) between 2010 and 2019 to analyze the trend of surgical service utilization in patients with lumbar spinal stenosis (LSS). Materials and Methods: The national patient sample data provided by the HIRA, which consisted of a 2% sample of the entire Korean population, was used to assess all patients who underwent decompression or fusion surgery at least once in Korea, with LSS as the main diagnosis from January 2010 to December 2019. An in-depth analysis was conducted to examine the utilization of surgical services, taking into account various demographic characteristics of patients, the frequency of claims for different types of surgeries, reoperation rates, the specific types of inpatient care associated with each surgery type, prescribed medications, and the overall expense of healthcare services. Results: A total of 6194 claims and 6074 patients were analyzed. The number of HIRA claims for patients increased from 393 (2010) to 417 (2019) for decompression, and from 230 (2010) to 244 (2019) for fusion. As for the medical expenses of surgery, there was an increase from United States dollar (USD) 867,549.31 (2010) to USD 1,153,078.94 (2019) for decompression and from USD 1,330,440.37 (2010) to USD 1,780,026.48 (2019) for fusion. Decompression accounted for the highest proportion (65.8%) of the first surgeries, but more patients underwent fusion (50.6%) than decompression (49.4%) in the second surgery. Across all sex and age groups, patients who underwent fusion procedures experienced longer hospital stays and incurred higher medical expenses for their inpatient care. Conclusion: The surgical service utilization of patients with LSS and the prescribing rate of opioids and non-opioid analgesics for surgical patients increased in 2019 compared to 2010. From mid-2010 onward, claims for fusion showed a gradual decrease, whereas those for decompression showed a continuously increasing trend. The findings of this study are expected to provide basic research data for clinicians, researchers, and policymakers.

https://www.semanticscholar.org/paper/c93ae5227fe322dca19e2175062c1fbcd1b9ea2a

3-[(Benzo-1,3-dioxol-5-yl)amino]-4-methoxycyclobut-3-ene-1,2-dione: polymorphism and twinning of a precursor to an antimycobacterial squaramide.

Acta Crystallographica Section C Structural Chemistry

1ebd1e5e-4e33-479c-be43-9dae6b0a128f

3--4-methoxycyclobut-3-ene-1,2-dione: polymorphism and twinning of a precursor to an antimycobacterial squaramide. 3--4-methoxycyclobut-3-ene-1,2-dione forms concomitant polymorphs, namely, block-shaped crystals of a monoclinic form I (space group P21/c, Z = 8, Z′ = 2) and needle-shaped crystals of a triclinic form II (space group P, Z = 4, Z′ = 2), the latter of which exhibits twinning by pseudomerohedry.

https://www.semanticscholar.org/paper/66e29dbf417cc9872aaa0f21e93f351f6ce77529

Nomogram for predicting difficult total laparoscopic hysterectomy: a multi-institutional, retrospective model development and validation study

International Journal of Surgery

b181ba74-e507-4d46-a2f9-d2ae419d7151

Nomogram for predicting difficult total laparoscopic hysterectomy: a multi-institutional, retrospective model development and validation study Background: Total laparoscopic hysterectomy (TLH) is the most commonly performed gynaecological surgery. However, the difficulty of the operation varies depending on the patient and surgeon. Subsequently, patient’s outcomes and surgical efficiency are affected. The authors aimed to develop and validate a preoperative nomogram to predict the operative difficulty in patients undergoing TLH. Methods: This retrospective study included 663 patients with TLH from Southwest Hospital and 102 patients from 958th Hospital in Chongqing, China. A multivariate logistic regression analysis was used to identify the independent predictors of operative difficulty, and a nomogram was constructed. The performance of the nomogram was validated internally and externally. Results: The uterine weight, history of pelvic surgery, presence of adenomyosis, surgeon’s years of practice, and annual hysterectomy volume were identified as significant independent predictors of operative difficulty. The nomogram demonstrated good discrimination in the training dataset , internal validation dataset , and external validation dataset . The calibration curves showed good agreement between the predictions and observations for both internal and external validations. Conclusion: The developed nomogram accurately predicted the operative difficulty of TLH, facilitated preoperative planning and patient counselling, and optimized surgical training. Further prospective multicenter clinical studies are required to optimize and validate this model.

https://www.semanticscholar.org/paper/50004b5c97ccaedf3bd6bea2ee6cffbcbbd0e7c1

How Does Chronic Back Pain Influence Quality of Life in Koreans: A Cross-Sectional Study

Asian Spine Journal

df6f7290-1c6f-4097-8b1c-3630ef93279b

How Does Chronic Back Pain Influence Quality of Life in Koreans: A Cross-Sectional Study Study Design A cross-sectional study. Purpose To explore the impact of chronic low back pain (CLBP) on individuals' quality of life; to understand current treatment practices and level of satisfaction with treatment in patients with CLBP. Overview of Literature Assessing subjective, patient-reported outcomes such as quality of life is essential to health care research. Methods Influences of the CLBP were analyzed via a questionnaire, which contained the character of CLBP, effect of pain management, Korean version Oswestry Disability Index (K-ODI) and Korean version of 12-item Short Form Health Survey (SF-12v2). Results Of 3,121 subjects who responded, 67.3% had moderate to severe pain; 43.5% presented prolonged CLBP of more than two years; and 32.4% had suffered from sleep disturbance due to pain. 22.8% of the patients were not satisfied with current pain management. The mean K-ODI score was 37.63; and it was positively correlated with the mean pain intensity (r=0.6, p<0.001). The SF-12v2 result was negatively correlated with mean pain intensity (PCS: r=-0.5, p<0.001; MCS: r=-0.4, p<0.001) and also negatively correlated with the K-ODI score (PCS: r=-0.75, p<0.001; MCS: r=-0.5, p<0.001). The conformity between patients and doctors in pain assessment was fair (κ=0.2463). Conclusions CLBP negatively affects quality of life. Of total 22.8% of the patients were not satisfied with current pain management. Such needs to be taken more seriously by doctors for improvement of satisfaction and quality of life in patients with CLBP.

https://www.semanticscholar.org/paper/d9f2a2ec20e845d00ecd61e04a888052f8798949

Nursing leaders' perceptions of the state of nursing leadership and the need for nursing leadership education reform: A qualitative content analysis from South Korea

Journal of Nursing Management

c1446c41-c9b1-4403-b8f2-4e136c534ff1

Nursing leaders' perceptions of the state of nursing leadership and the need for nursing leadership education reform: A qualitative content analysis from South Korea Abstract Aim This study aimed to clarify nursing leaders' perceptions of nursing leadership education and practice. Background Leadership is an essential competency that is required in nursing practice. It is also necessary to pay more attention to the development of nurses' leadership to improve patient safety and outcomes. Methods Participants were 15 nursing leaders. We adopted qualitative content analysis for data collected through individual and/or focus group interviews and analysed using the process of coding, condensing and categorizing. Results The results revealed the following five major themes with categories: (1) nursing leadership—commitment to nurses, the nursing profession and the organisation; (2) nursing leadership abilities—competency and compatibility, personality and traits; (3) importance of nursing leadership education to enhance educational efficiency and to nurture next‐generation nursing leaders; (4) difficulties in nursing leadership education: lack of perception and difficulty of implementation; and (5) strategies for nursing leadership education: contents and methods. Conclusions Nursing leaders' perception of nursing leadership was extended to nurses, organisations and nursing professions. Competency, capability, innate personality and traits are required nursing abilities that are acquired through education. Implications for Nursing Management Experience and theoretical‐based nursing leadership education should be introduced gradually and systematically from the beginning of nurses' careers.

https://www.semanticscholar.org/paper/67b23e1c8be66fb14baf1f03e00c5ea36c9b3659

Out With the Old; in With the New

Trauma Monthly

263ffb38-3d50-43b7-bd6b-f79b7f13a6e0

Out With the Old; in With the New Rapid advancements and research in the fields of medicine and the growing number of specialists are narrowing the spectrum of healthcare that general practitioners (GPs) can provide. In order to provide patients with an accurate diagnosis and proper treatment care, GPs have to refer their patients to the relevant specialist. This is why more and more GPs are inclined to pursue a specialty and more specialists are inclined to pursue a subspecialty. This trend as well as the daily increase of medical doctors is why fewer patients refer to GPs. This is the primary basis for upgrading journals of general medicine to more specialized ones. Having said that, it is with great pride that I introduce the initiation of the journal Trauma Monthly (TM) formerly known as the Kowsar Medical Journal (KMJ). KMJ was a persian medical journal targeting GPs as the primary readers and was not international; it failed to provide a worldwide forum to address issues of a specific field. In accord with the new policy adopted by our ministry of health, KMJ was upgraded to TM. This necessitated a total revamp of the journal with new editors, consultants and an international editorial board. This process was a time-taking, pain-staking undertaking by which the new English Medical journal TM evolved. TM seeks to provide scientists, specialists and traumatologists a medium to publish contemporary research in the fields of Trauma, Surgery and Emergency Medicine. It is an international peer-reviewed medical journal indexed in Scopus and Embase. TM aims to publish high-impact papers within a short time frame both in print and online. As the field of trauma is a vast one, submissions in the form of Original Articles, Reviews, Case Reports, Short Communications, Technical Reports, Iatrogenic Trauma, Surgical Pathology and Letters-to-the-Editor are accepted. All submissions are reviewed by the relevant section editor and peer reviewers. In order to expedite the publication process we have expanded the number of our reviewers. Because publication time is an important factor for contributing authors accepted manuscripts are immediately slated for publication. There are no fees of any sort for authors or institutions and all articles are permanently available online free of charge. I would like to take the opportunity here to thank the journal team for their endeavors. I hope TM meets the high expectations of our readers and remains up to par in upholding international standards.

https://www.semanticscholar.org/paper/718569d09c10dc8d50a5b336d3e2ca243fc8b537

Anatomy of the anterior cruciate ligament and the common autograft specimens for anterior cruciate ligament reconstruction

Annals of Joint

db040656-e799-428b-8e92-1d557a8bf200

Anatomy of the anterior cruciate ligament and the common autograft specimens for anterior cruciate ligament reconstruction A thorough understanding of the anatomical properties of the native anterior cruciate ligament (ACL), as well as the native specimens that are most commonly considered as viable autograft choices for anterior cruciate ligament reconstruction (ACLR), is warranted for continuing to pursue the best-possible graft choice for patients undergoing ACLR. While a wide variety of graft choices remain available to the operating surgeon, choosing the correct graft choice remains a consideration and discussion with patients on the pros and cons of each option. This article combines a review of the current literature on the quantitative and qualitative anatomy of the native ACL and common autograft specimens with the expert consensus of the senior author on the surgically-pertinent anatomy of these structures. The purpose of this article is to review the anatomy pertaining to the native ACL, along with the distal anatomy of the hamstring tendons, patellar tendon and quadriceps tendon (QT). Multiple tendinous and ligamentous structures exist around the knee that serve as viable candidates for use as autologous grafts for ACLR, and the anatomy of these distal extents of these structures are discussed thoroughly, including bony attachments, quantitative and relational anatomy, cross sectional area, and histological features of these structures.

https://www.semanticscholar.org/paper/3923c53be7f950c2b18926a4ca6d317394a40953

Retracted: Impact of Systematic Holistic Nursing Combined with Narrative Nursing Intervention for Patients with Advanced Gastric Cancer on Complications and Negative Emotions

Evidence-Based Complementary and Alternative Medicine

8bbffbf0-5dfc-4485-b4b1-d177fd330b21

Retracted: Impact of Systematic Holistic Nursing Combined with Narrative Nursing Intervention for Patients with Advanced Gastric Cancer on Complications and Negative Emotions .

https://www.semanticscholar.org/paper/a1f5d860f4a07d343c5afc7823ecc68617dfb32d

Provider Governance; A Basic Blackbox Seldom Looked at Properly: A Response to Recent Commentaries

International Journal of Health Policy and Management

081d6bfa-54a8-4f97-9d4b-2c66a335f798

Provider Governance; A Basic Blackbox Seldom Looked at Properly: A Response to Recent Commentaries The five commentaries on our initial article (1) provide valuable insights into the complex process of re-framing the relationships involved in provider side decision-making in the health sector...

https://www.semanticscholar.org/paper/619cbb09172f3e7b06ae251dfa6101981308af46

Advanced Thinking: Potable Reuse Strategies Gain Traction

Environmental Health Perspectives

74dbb751-54d9-4be5-baa6-52a5e58ea8dd

Advanced Thinking: Potable Reuse Strategies Gain Traction In 2011 city officials watched anxiously as the water supply for Wichita Falls, Texas, began to disappear. It was near the beginning of a historically severe drought that afflicts Texas and much of the Southwest to this day. For decades, Wichita Falls had drawn nearly all its drinking water from two reservoir lakes—Lake Arrowhead and Lake Kickapoo—but now water levels in those bodies had dropped from 88% of capacity to 55%.1 Advanced treatment capabilities enable cities to augment drinking water supplies with purified wastewater. This image shows treated water feeding into a microfiltration unit, part of the Orange County Groundwater Replenishment System. The Wichita Falls city leaders enacted the first of what would become five increasingly tough mandatory restrictions on residential water use. But as the lakes’ shorelines continued to recede, they realized the time had come to take bolder action. “We approached the TCEQ , and we said, ‘If this continues, our projections indicate that we could be out of water by 2014,’” recalls Daniel Nix, operations manager for the Wichita Falls Public Works Department. They needed a new water source, and they had one in mind: municipal wastewater. Following an earlier drought, the city had begun supplementing its drinking water supply with poorer-quality, high-saline water from two other lakes, Kemp and Diversion, which was treated using advanced treatment technologies including microfiltration and reverse osmosis.2 Nix was confident the same technologies could be used to produce potable water from wastewater. There was just one problem: neither Texas nor the federal government had any regulations governing such direct conversion of wastewater into drinking water—a process known as direct potable reuse (DPR). However, given the situation in Wichita Falls—a serious emergency coupled with readily available technology with the potential to deal with it—TCEQ said yes to trying DPR.3 “We sat down and worked with TCEQ to develop guidelines … that set the levels of treatment to ensure this water was completely safe for human consumption,” Nix says. When that was done, Wichita Falls spent $13 million to build a 12-mile pipeline connecting the wastewater treatment plant to the drinking water treatment facility.4 The treated effluent would be further purified using advanced treatment, then blended with reservoir water at a 50/50 ratio and treated once again. Then it would be stored for approximately 24 hours in a ground storage tank before being distributed to the public. The system went into operation on 9 July 2014, pumping million of gallons of blended water per day.5 “The vast majority of the people I’ve heard from say the water tastes great, that it’s actually better than the one-hundred-percent lake water,” Nix says. “The quality’s good, nobody’s gotten sick, and we haven’t had any problem with the plants. I’m very pleased with how Wichita Falls has put this together, and I think we’re showing that this can be done in the United States.”

https://www.semanticscholar.org/paper/6edf0e425b90dbbe8b2bd411d69f72e155e6b4b1

A Nordic Perspective on Patient Online Record Access and the European Health Data Space

Journal of Medical Internet Research

2baad992-2268-4c38-9120-e453622f2eeb

A Nordic Perspective on Patient Online Record Access and the European Health Data Space The Nordic countries are, together with the United States, forerunners in online record access (ORA), which has now become widespread. The importance of accessible and structured health data has also been highlighted by policy makers internationally. To ensure the full realization of ORA’s potential in the short and long term, there is a pressing need to study ORA from a cross-disciplinary, clinical, humanistic, and social sciences perspective that looks beyond strictly technical aspects. In this viewpoint paper, we explore the policy changes in the European Health Data Space (EHDS) proposal to advance ORA across the European Union, informed by our research in a Nordic-led project that carries out the first of its kind, large-scale international investigation of patients’ ORA—NORDeHEALTH (Nordic eHealth for Patients: Benchmarking and Developing for the Future). We argue that the EHDS proposal will pave the way for patients to access and control third-party access to their electronic health records. In our analysis of the proposal, we have identified five key principles for ORA: (1) the right to access, (2) proxy access, (3) patient input of their own data, (4) error and omission rectification, and (5) access control. ORA implementation today is fragmented throughout Europe, and the EHDS proposal aims to ensure all European citizens have equal online access to their health data. However, we argue that in order to implement the EHDS, we need more research evidence on the key ORA principles we have identified in our analysis. Results from the NORDeHEALTH project provide some of that evidence, but we have also identified important knowledge gaps that still need further exploration.

https://www.semanticscholar.org/paper/0282041c826b4c06cef0b3e45557f802586a52b3

The CONSORT statement

Saudi Journal of Anaesthesia

35b91fe4-8259-4f9a-8420-95dd06960d83

The CONSORT statement Randomized control trials (RCT's) are the gold standard in evaluating and efficiently translating research data into clinical practice. The CONSORT statement was conceptualized in order to help ascertain standardization and reproducibility of RCT's. The articles publishing the CONSORT 2010 statement along with their bibliographies were identified and thoroughly reviewed. The CONSORT statement is made up of a 25-item checklist that provides the author with a solid backbone around which to construct and present an RCT. It sets standards on the trial's design, analysis, and interpretation of the results.

https://www.semanticscholar.org/paper/17045af118b8e5dde74ebbdb868312a3c5168c02

Lived experiences of students with virological failure on antiretrovirals at a university in Limpopo

Curationis

8e8157fa-0793-4401-9209-829a5af05944

Lived experiences of students with virological failure on antiretrovirals at a university in Limpopo Background Human immunodeficiency virus (HIV)-positive students at a rural university in Limpopo province are followed-up according to the national guidelines for the treatment of HIV. Blood monitoring revealed that some students on antiretroviral (ARV) treatment were not virologically suppressed despite adherence and compliance being emphasised at every visit. Objectives The study sought to identify the students’ experiences that were hindering the viral load from improving. Method A two-phase qualitative, explorative, descriptive study design was followed. Convenience purposive sampling methods were taken on. By means of a semi-structured interview guide, face-to-face interviews were directed. Thematic content analysis was applied. Results Non-disclosure, noisy ARV packaging, stigma, and service delivery played a role in determining levels of student adherence and compliance with ARVs in the study sample. Conclusion Study findings suggest practical recommendations to improve compliance among students on ARVs: provision of HIV education to all students to help reduce stigma and make it easier to disclose HIV status; use of user-friendly noise-free packaging by pharmaceutical companies to enclose medication, such as blister packs; a supermarket approach in service delivery points to reduce the stigmatising effects of consulting rooms for ARV services. Contribution There is scope to examine the relevance of these findings for other students in the country, to compare them, and to use material from larger studies to guide targeted interventions that could improve adherence among young people.

https://www.semanticscholar.org/paper/1d107b87675abe12d32bc9dd323cc0890f49b592

Use of child safety seats during transportation of newborns

Korean Journal of Pediatrics

4c33f2a1-bd50-468d-93c1-40d5635baaa2

Use of child safety seats during transportation of newborns Purpose Child safety seats (CSS) are critical for the protection of children, in case of motor vehicle accidents. Although the national legislation mandates that all newborns must be placed in an appropriately installed CSS during transportation, people often do not perceive the importance of CSS and do not use it as recommended. The purpose of this survey was to understand the use of CSS for the safe transport of newborns from hospital to home. Methods We interviewed parents of newborn infants, using a structured questionnaire, at the time of their discharge from Cheil General Hospital & Women’s Health Care Center, between May 2014 and July 2014. Results A total of 403 participants were interviewed. The rate of CSS use was only 14.9%. Overall, 76.4% of the families interviewed were not aware about the recommendations on CSS use for newborns when travelling in a car. The provision of education on using CSS significantly influenced their rate of use. Parents who were educated about mounting the CSS in a car used it more as compared with others (25.7% vs. 12.2%) (P=0.002). Furthermore, if parents had heard about the importance or necessity of CSS, they used it more than others did (19.5% vs. 10.6%, P=0.032). Conclusion Despite the legal regulation, most parents transport their newborn infants without a CSS while traveling from hospital to their home. The rate of CSS use was influenced by parental education and their knowledge about its necessity. Education programs for parents must be reinforced to increase the CSS use.

https://www.semanticscholar.org/paper/8a63393e67b7db5b4741ea9216b9f7a5d78913ca

Retracted: The Use of Internet of Things and Cloud Computing Technology in the Performance Appraisal Management of Innovation Capability of University Scientific Research Team

Computational Intelligence and Neuroscience

f32b7322-b69c-4e63-801d-8f50784ef778

Retracted: The Use of Internet of Things and Cloud Computing Technology in the Performance Appraisal Management of Innovation Capability of University Scientific Research Team .

https://www.semanticscholar.org/paper/d4d6f53d36f77e0cabf31facde87d0943b3ffcb3

Nonpharmacological Modality of Treating Opioid Withdrawal

Indian Journal of Palliative Care

95fec493-b604-4ec1-bd0e-cb97eae6e598

Nonpharmacological Modality of Treating Opioid Withdrawal Sir, Opioid dependence is an alarming situation when a person is physiologically and psychologically addicted to an opioid. Opioid withdrawal is characterized by pupillary dilatation, severe muscle cramps, profuse diarrhea, abdominal cramps, yawning, piloerection, rhinorrhea, lacrimation, hypertension, tachycardia, temperature dysregulation, dementia, and delirium. Opioid withdrawal manifests in a palliative care patient if the opioid is not available on time or patient who was earlier dependent on it has stopped using it. Reason for stopping of opioid could be interruption of supply, financial issues, or due to intolerable adverse effects. Another reason of manifestation of withdrawal is when a route of administration of an opioid is changed (for example, tablet morphine is now changed to transdermal fentanyl patch for better patient compliance).

https://www.semanticscholar.org/paper/5969da496b42462163dc4713e144419af2b833df

Nanoencapsulation as a Promising Platform for the Delivery of the Morin-Cu(II) Complex: Antibacterial and Anticancer Potential

ACS Omega

d516f81c-009b-445d-b748-c827efa137d3

Nanoencapsulation as a Promising Platform for the Delivery of the Morin-Cu(II) Complex: Antibacterial and Anticancer Potential Nanoencapsulation has emerged as a promising approach for the effective delivery of poorly aqueous soluble compounds. The current study focuses on the preparation of human serum albumin (HSA)-based nanoparticles (NPs) and poly lactic-co-glycolic acid (PLGA)-based nanoparticles for effective delivery of the morin-Cu(II) complex. The NPs were analyzed based on different parameters such as particle size, surface charge, morphology, encapsulation efficiency, and in vitro release properties. The average particle sizes were found to be 214 ± 6 nm for Mor-Cu-HSA-NPs and 185 ± 7.5 nm for Mor-Cu-PLGA-NPs. The release of the morin-Cu(II) complex from both the NPs (Mor-Cu-HSA-NPs and Mor-Cu-PLGA-NPs) followed a biphasic behavior, which comprises an early burst release followed by a sustained and controlled release. The resulting NPs also exhibit free radical scavenging activity confirmed by a standard antioxidant assay. The antibacterial activities of the NPs were investigated using a disk diffusion technique, and it was observed that both the NPs showed better antibacterial activity than morin and the morin-Cu(II) complex. The anticancer activities of the prepared NPs were examined on MDA-MB-468 breast cancer cell lines using a cytotoxicity assay, and the mode of cell death was visualized using fluorescence microscopy. Our results revealed that NPs kill the cancer cells with greater efficiency than free morin and the morin-Cu(II) complex. Thus, both HSA-based NPs and PLGA-based NPs can act as promising delivery systems for the morin-Cu(II) complex and can be utilized for further biomedical applications.

https://www.semanticscholar.org/paper/f1d7c716f892370591bff2192543e46bfa5b5647

Broccoli aptamer allows quantitative transcription regulation studies in vitro

PLoS ONE

0aed7a40-85f3-4c66-9e1b-c1556c57001b

Broccoli aptamer allows quantitative transcription regulation studies in vitro Quantitative transcription regulation studies in vivo and in vitro often make use of reporter proteins. Here we show that using Broccoli aptamers, quantitative study of transcription in various regulatory scenarios is possible without a translational step. To explore the method we studied several regulatory scenarios that we analyzed using thermodynamic occupancy-based models, and found excellent agreement with previous studies. In the next step we show that non-coding DNA can have a dramatic effect on the level of transcription, similar to the influence of the lac repressor with a strong affinity to operator sites. Finally, we point out the limitations of the method in terms of delay times coupled to the folding of the aptamer. We conclude that the Broccoli aptamer is suitable for quantitative transcription measurements.

https://www.semanticscholar.org/paper/4ca1c45c798049f0c9ef61e36a72af803916ff82

40 Years Hard Labour

Ulster medical journal

aa6d27d0-f046-4ee6-af2c-460c46a888d0

40 Years Hard Labour I'm sorry to say that there's hardly a word that is research based in this “40 years hard labour”, but what surprises me is that my observation and experience is sometimes supported by subsequent research. This is an anecdotal account which I hope you will enjoy and find peppered with controversy, pearls of wisdom, and food for thought, but I expect it will not add one jot to the body of your knowledge, and most of you have probably not heard a lecture like this for some time. Not for my generation the PowerPoint lecture, but one written in longhand, which the author then performs. It is based on a chapter I was asked to write last year on essentially the same theme for a textbook for midwives.

https://www.semanticscholar.org/paper/96bc97b6e76acffec921602df5273b1f87516cda

A critique on nuclear factor-kappa B and signal transducer and activator of transcription 3: The key transcription factors in periodontal pathogenesis

Journal of Indian Society of Periodontology

8c7575fd-6f5a-484f-a247-3cbd44f72c79

A critique on nuclear factor-kappa B and signal transducer and activator of transcription 3: The key transcription factors in periodontal pathogenesis Periodontal disease is initiated by microorganisms in dental plaque, and host immunoinflammatory response to the microbial challenge helps in disease progression. Conventional periodontal therapy was mainly targeted on the elimination of microbial component. However, a better understanding of molecular aspects in host response will enable the clinicians to formulate effective host modulation therapy (HMT) for the periodontal management. Inflammatory mediators were the main targets for HMT in the past. Transcription factors can regulate the production of multiple mediators simultaneously, and inhibition of these factors will be more beneficial than blocking individual molecule. Two important transcription factors implicated in chronic inflammatory diseases are nuclear factor kappa B (NF-κB) and signal transducers and activators of transcription 3. The role of these factors in periodontal disease is a less explored area. This comprehensive review is aimed at unveiling the critical role of NF-κB and signal transducers and activators of transcription 3 in periodontal pathogenesis. An online search was performed using MEDLINE/PubMed database. All publications till 2016 related to NF-κB, signal transducer and activator of transcription 3 (STAT3), and inflammation were included in writing this review. A total of 27,390 references were published based on the search terms used. Out of these, 507 were related to the periodontal research published in English till 2016. Relevant papers were chosen after carefully reading the abstract. This review has attempted to comprehend the existing knowledge regarding the role of transcription factors NF-κB and STAT3 in periodontal disease. Moreover, it also provides a connecting molecular link for the periodontal medicine concept.

https://www.semanticscholar.org/paper/fb326a1cbe51599f708d7cd0a2a50e8bb39de5bf

Oncology Patient Interest in the Use of New Technologies to Manage Their Disease: Cross-Sectional Survey

Journal of Medical Internet Research

2baad992-2268-4c38-9120-e453622f2eeb

Oncology Patient Interest in the Use of New Technologies to Manage Their Disease: Cross-Sectional Survey Background Information and communication technologies (ICTs) in oncology can revolutionize the medical care of cancer patients. ICTs can promote patients’ empowerment and real-time disease monitoring. There is limited information about the impact of ICTs in cancer patients or their level of interest in using these tools for greater management of their condition. Objective This study aimed to understand the ICT usage profile in hematology-oncology patients to identify their needs and determine their level of interest in these technologies as a means of managing their disease. Methods A 28-item questionnaire was drawn up by a multidisciplinary team including pharmacists and oncologists. The questions were organized into 3 blocks, which were as follows: block A—sociodemographic characteristics; block B—use of ICTs when searching for health-related information; and block C—usage preferences for health apps. Hematology-oncology patients receiving treatment between May and July 2017 were included. A paper copy of the questionnaire was handed over to patients in either the day hospital or the pharmaceutical care consultancy in pharmacy services. Results A total of 650 questionnaires were handed out, with a participation of 94.0% (611/650). Patient sociodemographic characteristics were as follows: mean age was 57.8 years (age range: 19-91). Of 611 participants, 40.7% (249/611) had a university education, and 45.1% (276/611) of participants reported their overall state of health to be good. Results from use of ICTs when searching for health-related information were as follows: 87.1% (532/611) of participants were interested in being informed about health-related matters. Of all participants, 75.5% (532/611) sought information from health professionals and 61.3% (375/611) on the internet. Before going to their doctor’s appointment, 21.8% (133/611) of patients looked up information about their disease or treatment on the internet. This access to the internet rose to 50.9% (311/611) after their first medical appointment with their oncologist. Usage preferences for health apps were as follows: 82.7% (505/611) had a smartphone, whereas 20.3% (124/611) had a health app installed. Overall, 81.5% (498/611) would use an app if their health professional recommended it to them, but 39.6% (242/611) were not willing to pay for it. Conclusions The hematology-oncology patients showed a great deal of interest in searching for health-related information by means of ICTs, especially using smartphones and apps. The issues that drew the most interest in terms of apps were appointment management, advice on disease management, and communication with health professionals. Free access to these features and the recommendation by a health professional are important factors when it comes to their use. Therefore, the health care provider is a key element in the recommendation of ICTs, providing their knowledge and experience concerning their correct usage.

https://www.semanticscholar.org/paper/debb640a7c5a32bb715f62a4380c8e725daf2735

Impact of natural disaster on oral health: A scoping review.

Medicine

2ae18de8-1e0b-4f92-9aa3-866ffc4f36e7

Impact of natural disaster on oral health: A scoping review. Natural disasters may affect oral health as a result of serious damage to social function and public health. However, no article has systematically summarized the impact of natural disasters on oral health. This review aimed to map the existing literature on the impact of natural disasters on oral health. Targeted literature was searched using PubMed, Web of Science, Cochrane Library, and CINAHL databases with the keywords “disaster” and “oral health.” Eligibility criteria were established based on the Participant-Concept-Context model, and eligible studies were identified based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 flow diagram. Eight eligible studies related to earthquakes were included in this review. Of these, 7 studies were related to the 2011 Great East Japan Earthquake. Oral health status of victims of disaster was analyzed by assessing the following parameters: questionnaire surveys; examination for fungal infection; and analyses of the teeth, periodontal, and oral hygiene condition. Six studies suggested that natural disasters had a negative impact on oral health. Two studies could not determine the impact of natural disasters on oral health. Only 1 study analyzed the impact of disasters on oral health based on pre- and postdisaster surveys. This scoping review found that there was insufficient evidence to suggest a relationship between natural disasters and oral health and that there are biases in geographical areas and types of natural disasters in this research field. Further research is needed to promote evidence-based support by dental professionals during different disaster phases.

https://www.semanticscholar.org/paper/6c3fa9487df9e535c5a23ef2eff8c392705ba6ca

The medical profession and social reform, 1885–1945

Medicina e historia

01e1b869-8faa-4deb-8cd9-48453c0c239e

The medical profession and social reform, 1885–1945 of Surgeons of England, and Dr. Thomas's catalogue of it was published in 1970. The present work, however, is much more than an expanded and more detailed list of the holdings. It is a history of anaesthetics from the point of view of the pieces of apparatus used and the pioneers who devised them. There are sections on ether, chloroform, and nitrous oxide anaesthesia, on insufflation and endotracheal apparatus, on mixed vapours, analgesia, and on face-masks and drop methods. Each has a historical introduction and is beautifully illustrated (there are more than 230 illustrations altogether), and the well-written text is supported by many references to the literature. Although the author is dealing primarily with individual examples in the Collection he does compare them with contemporary pieces elsewhere which adds a useful comparative dimension. In view of the fact that most anaesthetic apparatus carries the name of its inventor this book will allow those interested to read a description of the original and an account of the man whose eponymous name may be in everyday use. When convenient he will then be able to examine the piece in the Collection. There is no other catalogue in the history of medicine akin to this one for it acts as a history of anaesthesia and of instrumental ingenuity, and at the same time is a scholarly guide to the artefacts themselves. It will be received enthusiastically by all those interested in the history of anaesthetics and by historians of medicine in general. Curators of museum collections, medical and non-medical, can take it as a prototype for the production of similar guides. The Association of Anaesthetists of Great Britain and Ireland are to be congratulated on their wish to have an inventory in this enlightened form, and also for selecting Dr. Bryn Thomas to produce it. He has produced a new kind of book and set high standards of excellence. The Collection, and therefore the book, does not proceed beyond World War II, but recent acquisitions will, it is hoped, make a further survey necessary. This will be received with equal indebtedness.

https://www.semanticscholar.org/paper/5d89756eb365c84e8d1d287892fec42de7db5a49

Extraosseous 99mTc-methylene diphosphonate uptake on bone scan: Unusual scenario

Indian Journal of Nuclear Medicine

71576d28-ad6e-4140-8387-29e01fef3b1c

Extraosseous 99mTc-methylene diphosphonate uptake on bone scan: Unusual scenario In nuclear medicine, 99mTc-methylene diphosphonate. (MDP) bone scan is one of the most commonly performed procedures. MDP uptake in nonosseous tissues is occasionally found in bone scan, and the knowledge of these kinds of extraosseous uptakes is of much clinical relevance. We report here two cases where bone scan showed extraosseous MDP uptake either hepatic or splenic apart from the physiological skeletal uptake.

https://www.semanticscholar.org/paper/f8a922d8804535030a049a1ea89d1ed240f73483

The Current Status of the Use of Internet Hospitals for Outpatients With Pain: Retrospective Study

Journal of Medical Internet Research

2baad992-2268-4c38-9120-e453622f2eeb

The Current Status of the Use of Internet Hospitals for Outpatients With Pain: Retrospective Study Background The national “Internet +” policies and the emergence of internet hospitals have created a new direction for the management of pain outside of the hospital. Nevertheless, there are no consolidated studies conducted by pain physicians on the current state of internet hospital–based online medical services used by patients with pain outside of a hospital setting. Objective In this retrospective study, we aimed to examine the status of the use of internet hospitals by patients who experience pain. Moreover, we identified the factors that influenced patients' decisions to make an online visit through the internet hospital. Methods Detailed information was collected online and offline from outpatients with pain at the information technology center of West China Hospital of Sichuan University from February 2020 to April 2022. Binary logistic regression analysis was conducted to identify the determinants that influenced patients' decisions to make an online visit to the internet hospital. Results Over a 2-year period, 85,266 pain-related clinic visits were recorded. Ultimately, 39,260 patients were enrolled for the analysis, with 12.9% (5088/39,260) having online visits. Both online and offline clinics had a greater number of visits by women than men. The average age of patients attending the online clinic was 46.85 (SD 16.56) years, whereas the average age of patients attending the offline clinic was 51.48 (SD 16.12) years. The majority of online clinic visitors (3059/5088, 60.1%) were employed, and one of the most common occupations was farming (721/5088, 14.2%). In addition, 51.8% (2635/5088) of patients who participated in the online clinics lived outside the hospital vicinity. Young (odds ratio 1.35, 95% CI 1.01-1.81; P=.045) and middle-aged (OR 1.98, 95% CI 1.81-2.16; P<.001) patients, employed patients (OR 1.11, 95% CI 1.04-1.18; P=.002), nonlocal patients (OR 1.57, 95% CI 1.48-1.67; P<.001), and the ordinary staff (OR 1.19, 95%CI 1.01-1.39; P=.03) were more likely to have the intention to choose online visits through the internet hospitals. Conclusions Internet hospitals are flourishing as a more efficient and promising method of pain management and follow-up for patients with pain outside the hospital. People with pain who are young, working, and not in the vicinity of hospitals are more likely to visit internet hospitals.

https://www.semanticscholar.org/paper/79c7774ebb632f8d49438547ccaa38eb325e0fed

2358. Acute Flaccid Myelitis Among Hospitalized Children in Texas, 2016

Open Forum Infectious Diseases

f20432ac-3c14-4779-bc66-2f24e1b2715e

2358. Acute Flaccid Myelitis Among Hospitalized Children in Texas, 2016 Abstract Background This is a multisite study of cases of acute flaccid myelitis (AFM) in Texas during the year 2016 among 6 children’s hospitals. AFM is a newly recognized and poorly understood disease. Information related particularly to pathogenesis, treatment, and recovery are lacking. Methods Children age 0–18 years admitted with AFM defined as acute onset limb weakness with spinal cord lesions on MRI primarily involving gray matter during January 1–December 31, 2016, were reviewed. Abstracted information included demographics, presentation, laboratory findings, treatments, and long-term outcomes up to 18 months after onset of weakness (range 3.5–18 months; median 15 months). Results 22 patients from 5 hospitals were included. Median age was 4.9 years. Upper extremity involvement was common (77%), with all extremities being involved in 36%. Enterovirus D68 was identified in 3 cases. Other pathogens identified included human parechovirus (n = 2), human herpesvirus 6 (n = 1), non-D68 enterovirus (n = 2), rhinovirus (n = 1), Mycoplasma pneumoniae (n = 1), Bartonella henselae (n = 1), and influenza B (n = 1). In total, 32% recovered fully in strength and function, and 45% had full recovery of function. 18% remain completely dependent on caregivers. All extremities were involved in 8 patients. 6 had significant residual weakness, ranging from flaccidity in one extremity to complete caregiver dependence. One was lost to follow-up after discharge. None of the three patients with Enterovirus D-68 made a full recovery, and all three remain largely dependent on caregivers. Treatments varied, but most commonly included methylprednisolone (n = 14) or intravenous immunoglobulin (IVIG) (n = 13). All cases of full recovery were treated with steroids, IVIG, or both. 4 patients were not treated; 2 with eventual recovery of function (Figure 1). Response to IVIG and steroids was variable; no harm was noted in response to IVIG (Figure 2). Conclusion Our findings overall show more promising outcomes than those seen in the 2014 nationwide outbreak of AFM. Specific treatments were not associated with better outcomes. IVIG appeared to be helpful in several cases and, at the very least, was not harmful. Patients with all extremities involved and/or enterovirus D68 appear to have poorer outcomes. Disclosures All authors: No reported disclosures.

https://www.semanticscholar.org/paper/1f510d46c5b522f2434f8321b472a819586a1108

Reciprocity in Low Back Pain Care and Its Role in Power Dynamics: A Give-and-Take Approach

Physical Therapy

d72d7ef7-93f2-45e7-a0de-f97f34bdacff

Reciprocity in Low Back Pain Care and Its Role in Power Dynamics: A Give-and-Take Approach Abstract Objective The shift toward patient-centered care in physical therapy fostered a deeper consideration of power-sharing in clinical interactions. Elements of reciprocity may enhance such power considerations between physical therapist and patients, but there has been little investigation into how reciprocity is enacted in physical therapy, its value, and how to improve it if required. This study investigates forms of reciprocity during physical therapist–patient interactions in low back pain (LBP) care with the aim of enhancing patient-centered approaches. Methods The qualitative design involved (1) ethnographic observations at a fee-for-service practice in Australia, and (2) reflexive discussions between researchers and participating clinicians. To understand reciprocity, the analysis drew from the concepts of “accepting’”(or “blocking”) “offers” that have been previously applied to physical therapy interactions. The analysis is a sub-study using a larger dataset and analyses in which we partnered with physical therapists and people living with LBP. Results Forty-nine observations and 13 reflexive discussions were undertaken with 42 people with LBP and 10 physical therapists. Analysis developed 3 themes suggesting that forms of reciprocity depended on physical therapists accepting or blocking patients’ offers, inviting patients to make an offer, and offering personal stories. These elements of reciprocity are relevant to power-sharing during interactions and may impact patient-centered care. Conclusion Our results suggest that attending to forms of reciprocity can help physical therapists shift power in clinical interactions. By inviting and accepting “offers,” physical therapists may build collaborative interactions, support individuals to guide the treatment narrative, and shift away from biomedically centered management approaches. Such recommendations create reciprocal environments that might enhance patient-centered care. Impact This is one of the few studies to explore how reciprocity is enacted in interactions between physical therapists and s with LBP. Our findings highlight how engaging with the concept of reciprocity could assist with sharing power, improving physical therapist–patient relationships, and enhancing patient-centered care.

https://www.semanticscholar.org/paper/82fca2baa998121d7a706aa14f9a83db9355641d

Data-driven approach for the delineation of the irritative zone in epilepsy in MEG

PLoS ONE

0aed7a40-85f3-4c66-9e1b-c1556c57001b

Data-driven approach for the delineation of the irritative zone in epilepsy in MEG The reliable identification of the irritative zone (IZ) is a prerequisite for the correct clinical evaluation of medically refractory patients affected by epilepsy. Given the complexity of MEG data, visual analysis of epileptiform neurophysiological activity is highly time consuming and might leave clinically relevant information undetected. We recorded and analyzed the interictal activity from seven patients affected by epilepsy (Vectorview Neuromag), who successfully underwent epilepsy surgery (Engel > = II). We visually marked and localized characteristic epileptiform activity (VIS). We implemented a two-stage pipeline for the detection of interictal spikes and the delineation of the IZ. First, we detected candidate events from peaky ICA components, and then clustered events around spatio-temporal patterns identified by convolutional sparse coding. We used the average of clustered events to create IZ maps computed at the amplitude peak (PEAK), and at the 50% of the peak ascending slope (SLOPE). We validated our approach by computing the distance of the estimated IZ (VIS, SLOPE and PEAK) from the border of the surgically resected area (RA). We identified 25 spatiotemporal patterns mimicking the underlying interictal activity (3.6 clusters/patient). Each cluster was populated on average by 22.1 spikes. The predicted IZ maps had an average distance from the resection margin of 8.4 ± 9.3 mm for visual analysis, 12.0 ± 16.5 mm for SLOPE and 22.7 ±. 16.4 mm for PEAK. The consideration of the source spread at the ascending slope provided an IZ closer to RA and resembled the analysis of an expert observer. We validated here the performance of a data-driven approach for the automated detection of interictal spikes and delineation of the IZ. This computational framework provides the basis for reproducible and bias-free analysis of MEG recordings in epilepsy.

https://www.semanticscholar.org/paper/ee05658f61ac79c761584d57e8f6cbc053f1aa0f

Melatonin decreases androgen-sensitive prostate cancer growth by suppressing SENP1 expression

Translational Andrology and Urology

d5fbf520-f611-4526-b564-b6fa362d68e9

Melatonin decreases androgen-sensitive prostate cancer growth by suppressing SENP1 expression Background Melatonin is a hormone naturally produced by the pineal gland in the brain. In addition to modulating circadian rhythms, it has pleiotropic biological effects including antioxidant, immunomodulatory, and anti-cancer effects. Herein, we report that melatonin has the ability to decrease the growth and metastasis of androgen-dependent prostate cancer. Methods To evaluate the anti-cancer effect of melatonin on androgen-sensitive prostate cancer in vitro or in vivo, the effects of cell proliferation, apoptosis, migration and invasion were analyzed by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), colony formation, flow cytometry, Transwell assay, and immunohistochemistry (IHC), respectively. Next, the interaction between androgen receptor (AR) and SUMO specific protease 1 (SENP1) was detected by real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blotting, and confirmed by luciferase reporter assay. Furthermore, the Small Ubiquitin-like Modifier (SUMO) proteins are a group of small proteins that are covalently attached to and detached from other proteins in cells to modify their function. (SUMOylation) of histone deacetylases 1 (HDAC1) was measured by proximity ligation assay (PLA). Results The treatment of melatonin cripples the transcriptional activity of AR, which is essential for the growth of the androgen-dependent prostate cancer cell, LNCaP. The lower activity of AR was dependent on melatonin induced SUMOylation of HDAC1, which has been established as a key factor for the transcriptional activity of AR. Mechanistically, the effect of melatonin on AR was due to the decreased SENP1 protein level and the subsequent increased HDAC1 SUMOylation level. The overexpression of SENP1 abrogated the anti-cancer ability of melatonin on LNCaP cells. Conclusions These findings indicate that melatonin is a suppressor of androgen-dependent prostate cancer tumorigenesis.

https://www.semanticscholar.org/paper/6ca0d4e7b68616cc770b5378f0d84b3cf4ae1acf

Reduction of Enterococcus faecalis in curved root canals after various sizes and tapers of canal preparation

Journal of Conservative Dentistry

6210b338-b111-468c-8194-ea3f187883ab

Reduction of Enterococcus faecalis in curved root canals after various sizes and tapers of canal preparation Aims: The aim of this study was to evaluate the reduction of Enterococcus faecalis in curved root canals after various sizes and tapers of the canal preparation. Materials and Methods: Mandibular first molars (n = 103) with curved mesiobuccal canals were divided into one control (n = 5) and 7 experimental (n = 14) groups, were inoculated with E. faecalis (ATTC 29212) and prepared with the following RaCe files (FKG Dentaire) as master apical file: Groups: 25.04, 25.06, 30.04, 30.06, 35.04, 35.06 and 40.06. All the experimental groups were irrigated with 2 mL of 1% sodium hypochlorite during instrumentation and finally rinsed with 17% ethylenediaminetetraacetic acid (EDTA) (2 mL) followed by 5.25% NaOCl (2 mL) and sterile distilled water. Colony counting was performed after incubation. Statistical Analysis Used: Resulting data were analyzed using one-way ANOVA and Tukey's post-hoc test, (P < 0.05). Results and Conclusions: All the experimental groups showed significant bacterial reduction (P < 0.001). Although the greater the size/taper or both led to more decreased amount of bacteria, differences between the groups with the identical size and different tapers, and among the groups with the same taper and different sizes were not significant. Based on this study, 25.04 along with using 2 mL of 1% NaOCl during instrumentation, and using 17% EDTA and 5.25% NaOCl as final rinse successively after the termination of preparation, can effectively reduce intra-canal bacteria and preserve root structure.

https://www.semanticscholar.org/paper/088b995b683b1e14ea8817049f8f153068dafa48

Epidemiology, Public Health, and Public Policy

Preventing Chronic Disease

5124ec7c-50cc-4843-a2c5-2947fa56354b

Epidemiology, Public Health, and Public Policy I left the Centers for Disease Control and Prevention (CDC) more than 4 years ago to go to the Robert Wood Johnson Foundation (RWJF). RWJF had gone through a time of substantial rethinking about its role in society and come to the conclusion that the focus should not be grantmaking; it should be creating social change for health. This could just as easily be said about public health — creating societal change to improve the health of the public. At its core, public policy is the way a society frames what it wishes to become. Does it want all children immunized? Does it want to limit the use of tobacco? Policy doesn't have to be federal legislation or regulation; it can be corporate or local or state. But an organization, a field, or groups that are about social change will find they are often about influencing public policy. How does this fit with epidemiology and its history, and the history of CDC? It is unlikely that John Snow would be revered in public health if he had merely studied cholera. His defining moment was when he removed the pump handle from the contaminated well that was the source of the epidemic. That intervention is honored with an award called the Pump Handle Award that is given by the Council of State and Territorial Epidemiologists. Our heroes have been tied to action. In 1983, giving the Wade Hampton Frost Lecture at the American Public Health Association meeting, Bill Foege, former CDC director, coined the term consequential epidemiology. Foege was taking sides in an active debate of the time by saying that epidemiology "is a tool to change the world, not merely to study the world" (unpublished material, 1983). The debate that Foege was speaking to was whether epidemiologists should engage in the political process. Should they advocate solutions about what should happen based on the science or merely do the science and let the advocates and policy makers use the science? Some people said that scientists would lose their objectivity if they took on this more activist role. This discussion has come back, quite strongly, in recent times in the context of the politicization of science. Politics and public policy can be tough business, especially recently. Bill Foege was of a very different opinion. It was his conviction that public health was inherently political, inescapably political. Foege argued that public health work occurs in a political context and that, divorced from that context, our science is stillborn, a missed opportunity. To pretend otherwise is self-delusion and a failure of vision and responsibility. The purpose of this essay is to reaffirm that connection to activism. I state this not despite recent concerns about politicization of science but because of them. We must embrace both 1) activism and commitment to social change as central to public health, and 2) the central purpose of epidemiologic science, which is to find, assess, and confirm truth, regardless of past findings or beliefs. These are different roles, and the space between them is where the real excitement is. Actions are being taken based on the science as it is known today, but the actions will change as the science advances. We are entering a period of economic pressure that is likely to change the nature of America's medical care, the largest industry in our nation. We now spend about twice as much as other developed countries per capita per year. Despite the importance of biological science as the basis for improvements in diagnosis and therapy, it is impossible to think of major changes in the medical care system that will not play out in public policy changes. The public's health and the societal factors that affect health span a much greater proportion of our economy and our society than even medical care does. This means that public health will have to address issues that have political implications. Yet the science behind what can be done does not mean it will be done. Our policy makers and the public have not been nearly as committed to the understanding that how our society is organized, what our policies foster or inhibit, what our communities encourage and our institutions support are fundamental causes of good or ill health, just like biological causes, and they warrant study and action. If societal forces are not in alignment, scientific advances stall, and the value realized is a meager fraction of its potential. Scientific understanding about any disease that is not widely applied to people in need is ultimately wasted. Similarly, widespread application of practices and policies that have no scientific evidence of effectiveness are just as futile. Scientific discovery and widespread application must never be separated. This is a defining tension for all of public health. Scientists never feel they know enough to act. Practitioners and activists say the health problems are so significant we must act now; we can't wait for the science to be finalized. Both are right. Organizations only responsible for research will worry less about whether the findings are widely applied or are feasible and practical. Organizations only responsible for programs will likely hold to outmoded ways that are ineffective if their staff and clients like the program. Managed well, the combined responsibilities make both science and program better.

https://www.semanticscholar.org/paper/966465ae0abd2d90ac7f2f583cfcfd2ef0f6ca4e

Alcohol-impaired driving among adults—USA, 2014–2018

Injury Prevention

dc811d66-51f0-49c7-a652-62e4da8433a3

Alcohol-impaired driving among adults—USA, 2014–2018 Introduction Alcohol-impaired driving (AID) crashes accounted for 10 511 deaths in the USA in 2018, or 29% of all motor vehicle-related crash deaths. This study describes self-reported AID in the USA during 2014, 2016 and 2018 and determines AID-related demographic and behavioural characteristics. Methods Data were from the nationally representative Behavioral Risk Factor Surveillance System. Adults were asked ‘During the past 30 days, how many times have you driven when you have had perhaps too much to drink?’ AID prevalence, episode counts and rates per 1000 population were estimated using annualised individual AID episodes and weighted survey population estimates. Results were stratified by characteristics including gender, binge drinking, seatbelt use and healthcare engagement. Results Nationally, 1.7% of adults engaged in AID during the preceding 30 days in 2014, 2.1% in 2016 and 1.7% in 2018. Estimated annual number of AID episodes varied across year (2014: 111 million, 2016: 186 million, 2018: 147 million) and represented 3.7 million, 4.9 million and 4.0 million adults, respectively. Corresponding yearly episode rates (95% CIs) were 452 (412–492) in 2014, 741 (676–806) in 2016 and 574 (491–657) in 2018 per 1000 population. Among those reporting AID in 2018, 80% were men, 86% reported binge drinking, 47% did not always use seatbelts and 60% saw physicians for routine check-ups within the past year. Conclusions Although AID episodes declined from 2016 to 2018, AID was still prevalent and more common among men and those who binge drink. Most reporting AID received routine healthcare. Proven AID-reducing strategies exist.

https://www.semanticscholar.org/paper/37a89fd089ce1d01c7b6d06a0d770d62e62d90ae

Exercise preconditioning exhibits neuroprotective effects on hippocampal CA1 neuronal damage after cerebral ischemia

Neural Regeneration Research

18b45ae1-2727-4c68-afd1-a9c56e174c48

Exercise preconditioning exhibits neuroprotective effects on hippocampal CA1 neuronal damage after cerebral ischemia Recent evidence has suggested the neuroprotective effects of physical exercise on cerebral ischemic injury. However, the role of physical exercise in cerebral ischemia-induced hippocampal damage remains controversial. The aim of the present study was to evaluate the effects of pre-ischemia treadmill training on hippocampal CA1 neuronal damage after cerebral ischemia. Male adult rats were randomly divided into control, ischemia and exercise + ischemia groups. In the exercise + ischemia group, rats were subjected to running on a treadmill in a designated time schedule (5 days per week for 4 weeks). Then rats underwent cerebral ischemia induction through occlusion of common carotids followed by reperfusion. At 4 days after cerebral ischemia, rat learning and memory abilities were evaluated using passive avoidance memory test and rat hippocampal neuronal damage was detected using Nissl and TUNEL staining. Pre-ischemic exercise significantly reduced the number of TUNEL-positive cells and necrotic cell death in the hippocampal CA1 region as compared to the ischemia group. Moreover, pre-ischemic exercise significantly prevented ischemia-induced memory dysfunction. Pre-ischemic exercise mighct prevent memory deficits after cerebral ischemia through rescuing hippocampal CA1 neurons from ischemia-induced degeneration.

https://www.semanticscholar.org/paper/9f323acc94d31ce9c2221fd7a995f951cc6c352b

Retracted: Correlation between Serum LP-PLA2 and sST2 Levels and the Condition of Patients with Acute Heart Failure and Their Prognostic Value

Evidence-Based Complementary and Alternative Medicine

8bbffbf0-5dfc-4485-b4b1-d177fd330b21

Retracted: Correlation between Serum LP-PLA2 and sST2 Levels and the Condition of Patients with Acute Heart Failure and Their Prognostic Value .

https://www.semanticscholar.org/paper/414ebf0d9853f6a21005d1fbcd7492818bdfa38e

Involvement of DNA mismatch repair in the maintenance of heterochromatic DNA stability in Saccharomyces cerevisiae

PLoS Genetics

22203759-0bc9-4429-8b67-4140ab209cef

Involvement of DNA mismatch repair in the maintenance of heterochromatic DNA stability in Saccharomyces cerevisiae Heterochromatin contains a significant part of nuclear DNA. Little is known about the mechanisms that govern heterochromatic DNA stability. We show here that in the yeast Saccharomyces cerevisiae (i) DNA mismatch repair (MMR) is required for the maintenance of heterochromatic DNA stability, (ii) MutLα (Mlh1-Pms1 heterodimer), MutSα (Msh2-Msh6 heterodimer), MutSβ (Msh2-Msh3 heterodimer), and Exo1 are involved in MMR at heterochromatin, (iii) Exo1-independent MMR at heterochromatin frequently leads to the formation of Pol ζ-dependent mutations, (iv) MMR cooperates with the proofreading activity of Pol ε and the histone acetyltransferase Rtt109 in the maintenance of heterochromatic DNA stability, (v) repair of base-base mismatches at heterochromatin is less efficient than repair of base-base mismatches at euchromatin, and (vi) the efficiency of repair of 1-nt insertion/deletion loops at heterochromatin is similar to the efficiency of repair of 1-nt insertion/deletion loops at euchromatin.

https://www.semanticscholar.org/paper/3b4dff465c9977a3506b3e9e7eeb09e5c9de86ec

Introduction to Present Day Psychology

Mental Health

Introduction to Present Day Psychology Any writer of an introduction to psychology is now faced with something of a dilemma. He can discuss fairly intensively certain basic problems and discoveries so as to make their nature clear to the ordinary reader, or he can make an all-embracing survey of the extensive field of modern psychology with illustrative reference to a landmark here and a signpost there. Dr. Boenheim has chosen the latter course. The book is based on a

https://www.semanticscholar.org/paper/b9ff3f866c2cee37a4045c3adadc51dcb1ea9288

Falling for a Balance Partner

Frontiers in Public Health

d3dd5449-daa1-4d57-9412-9add6037584f

Falling for a Balance Partner The growing accumulation of knowledge about fall prevention strategies primarily reflects a research perspective where intervention data are rigorously collected and analyzed. However, the voices of program deliverers or participants who are part of these interventions are often aggregated and thus muted. With recognition of the growing importance of patient-centered care, we wanted to provide a personal reflection on the Balance Partner program, a CDC funded project to train peer leaders in fall prevention. In the story below, Sara was trained as a Balance Partner using a curriculum developed at The University of North Carolina’s Center for Health Promotion and Disease Prevention. The Balance Partner Program provides training and support to community volunteers who are paired with a peer who is at risk for falls. Together, Balance Partners plan strategies to decrease the likelihood of a fall – strategies that could include joining a balance exercise program, improving home safety, or getting a vision check-up. By addressing social and emotional factors alongside knowledge about falls, the Balance Partner Program aims to increase older adults’ overall adherence to fall prevention activities above the 50% rate reported in literature (1). Sara, a 69-year-old volunteer, was paired with Georgia, who screened at high risk for falls during a Building Better Balance Screening in Asheville, NC, USA. As of this writing, Sara and Georgia had worked together for almost 6 months to implement strategies to reduce their falls risk.

https://www.semanticscholar.org/paper/4f829d07dd0738c0f49b41955cde7c7df6614e84

Correction: Derivation and validation of a clinical prediction model for risk-stratification of children hospitalized with severe pneumonia in Bangladesh

PLOS Global Public Health

832296cf-d6ac-4f46-9515-ed955025395e

Correction: Derivation and validation of a clinical prediction model for risk-stratification of children hospitalized with severe pneumonia in Bangladesh .

https://www.semanticscholar.org/paper/9eb45f9fa4eae727b47c98d282f10032b9144b2b

PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation

bioRxiv

027ffd21-ebb0-4af8-baf5-911124292fd0

PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation The platelet-derived growth factor receptor (PDGFR) family of receptor tyrosine kinases allows cells to communicate with one another by binding to growth factors at the plasma membrane and activating intracellular signaling pathways to elicit responses such as migration, proliferation, survival and differentiation. The PDGFR family consists of two receptors, PDGFRα and PDGFRβ, that dimerize to form PDGFRα homodimers, PDGFRα/β heterodimers and PDGFRβ homodimers. Here, we overcame prior technical limitations in visualizing and purifying PDGFRα/β heterodimers by generating a cell line stably expressing C-terminal fusions of PDGFRα and PDGFRβ with bimolecular fluorescence complementation fragments corresponding to the N-terminal and C-terminal regions of the Venus fluorescent protein, respectively. We found that these receptors heterodimerize relatively quickly in response to PDGF-BB ligand treatment, with a peak of receptor autophosphorylation following 5 minutes of ligand stimulation. Moreover, we demonstrated that PDGFRα/β heterodimers are rapidly internalized into early endosomes, particularly signaling endosomes, where they dwell for extended lengths of time. We showed that PDGFRα/β heterodimer activation does not induce downstream phosphorylation of ERK1/2 and significantly inhibits cell proliferation. Further, we characterized the PDGFR dimer-specific interactome and identified MYO1D as a novel protein that preferentially binds PDGFRα/β heterodimers. We demonstrated that knockdown of MYO1D leads to retention of PDGFRα/β heterodimers at the plasma membrane, resulting in increased phosphorylation of ERK1/2 and increased cell proliferation. Collectively, our findings impart valuable insight into the molecular mechanisms by which specificity is introduced downstream of PDGFR activation to differentially propagate signaling and generate distinct cellular responses. One-sentence summary PDGFRα/β heterodimer binding to MYO1D contributes to rapid internalization of the dimerized receptors, thereby negatively affecting downstream ERK1/2 signaling and cellular proliferation.

https://www.semanticscholar.org/paper/5f8fc79c77ebc536ccfd5d01f4b01b5bba39b037

Facial Candling for the Treatment of Allergic Rhinitis in Young Adults: A Qualitative Study

Journal of Pharmacy and Bioallied Sciences

78f0693c-2254-425e-9816-0af30e467821

Facial Candling for the Treatment of Allergic Rhinitis in Young Adults: A Qualitative Study Aims: Facial candling is one of the traditional treatments that is claimed to be able to help in curing or reducing various allergy and inflammation conditions such as allergic rhinitis. We aimed to explore the perceptions of participants with allergic rhinitis toward their disease conditions and facial candling treatment. Materials and Methods: The study used a qualitative exploratory design, comprising 12 in-depth interviews. A semi-structured topic guide was used to explore all relevant aspects of the topic, which were audio recorded, transcribed verbatim. All the interviews were conducted in a few beauty salons in purposively selected city areas in the state of Kedah, Malaysia. Results: Of the 12 patients, seven (58%) reported a positive experience of facial candling treatment, with improvement in the condition of their allergic rhinitis. Specific themes about the experience of facial candling treatment that were identified within the transcript data included knowledge about facial candling, options for disease treatment, effectiveness of facial candling, sources of information, comparison, application of treatment, treatment budget, and safety. The major strength lies in the fact that reasons for using facial candling were uncovered from the perspectives of people with allergic rhinitis through the in-depth interviews. Conclusions: The motives of these participants for using facial candling are mainly due to cultural influence and its low cost of treatment. There were mixed responses from the participants about the usefulness of facial candling. Most of the respondents had not assessed the safety of prolonged use of facial candling and regarded it as a safe procedure as this has been practiced for generations.

https://www.semanticscholar.org/paper/16e6f877fb1ae44d2c8c97560d148b53eb8aa1ce

Principles and Practice of Chemotherapy: With Special Reference to the Specific and General Treatment of Syphilis

The Indian medical gazette

7bc8c601-4efa-400f-972e-164343190429

Principles and Practice of Chemotherapy: With Special Reference to the Specific and General Treatment of Syphilis The: chemotherapy and general treatment of syphilis is here dealt with in considerable detail, because of the great practical importance of the subject, and because the greatest advance in this new field of therapeutic science has been made in the treatment of syphilis. It is true that most advance has been made in the treatment of syphilis, relapsing fever, framboesia tropica and other spirochetal infections, in trypanosomiasis, leishmaniasis, schistosomiasis, piroplasmosis, malaria, amoebic and other protozoal and metazoal infections but some real progress, with practical applications, has also been made in the great and important field of bacterial diseases, and especially when chemotherapy is employed for the treatment of local as well as of systemic infections. Chemotherapy commands a large share of attention and effort in medical research to-day, and this volume is of service to both the investigator and the practising physician.

https://www.semanticscholar.org/paper/de79d89b7c3fe8f02e688511d9343aae079a5bf8

Round the Hospitals

The Hospital

965d752e-3d99-47a6-bf0f-de96ba26b1f3

Round the Hospitals The annual meeting of the College of Nursing held on June 18 at Manchester was in all respects a very notable function. The choice of this locality for the gathering was justified by our excellent attendance. Many members came from London, some from Brighton, Truro, and every part of England and Wales, some even from the north of Scotland and from Ireland. Over 300 nursing sisters were present and the traditional hospitality of Manchester was well illustrated in the reception they received at the hands of the Local Centre in that town, and of the Lord Mayor and Lady Mayoress'. The high educational ideas of the

https://www.semanticscholar.org/paper/c1c1519d41e2e7a37f8de90e199a84f19f642a17

[μ-Bis(diphenylphosphanyl)acetonitrile-κ2 P:P]bis[chloridogold(I)]

Acta Crystallographica Section E

3764f162-def2-425e-a8d5-f015eb75ff7a

bis The title complex, , has an intra-molecular Au⋯Au inter-action of 3.1669 (4) Å, but no inter-molecular Au⋯Au inter-actions in the solid state. The Cl-Au-P bond angle of 176.84 (7)° is slightly distorted from linearity. The P-C bond length to the phenyl group is shorter than the P-C bond length to the bridging carbon, indicative of the flexibility of the bidentate bite of the ligand. The C-C N fragment is essentially linear at 179.5 (9)° and the C N bond length of 1.125 (11) Å indicates predominantly triple-bond character. In the crystal packing, there are no hydrogen-bonding or aurophilic inter-actions between the mol-ecules.

https://www.semanticscholar.org/paper/41ce1377af2ec186e2578eee04289ba37528fdcd

Interleukin-35 mitigates the function of murine transplanted islet cells via regulation of Treg/Th17 ratio

PLoS ONE

0aed7a40-85f3-4c66-9e1b-c1556c57001b

Interleukin-35 mitigates the function of murine transplanted islet cells via regulation of Treg/Th17 ratio Pancreatic islet transplantation is a promising treatment for type 1 diabetes (T1D). Interleukin-35 (IL-35) is a recently discovered cytokine that exhibits potent immunosuppressive functions. However, the role of IL-35 in islet transplant rejection remains to be elucidated. In this study, we isolated islet cells of BALB/c mouse and purified CD4+ T cell subsets of a C57BL/6 mouse. The model for islet transplantation was established in vitro by co-culture of the islet cells and CD4+ T cells. IL-35 (20 ng/ml) was administered every other day. Following co-culture, the islet function and Treg/Th17 ratio were analyzed on days 1, 3, and 5. Furthermore, the Th17/Treg ratio was modulated (1:0–2), and the function of islet cells as well as proliferation of Th17 cells were analyzed. T cell sorting was performed using the magnetic bead sorting method; Treg and Th17 count using flow cytometry; cell proliferation detection using the carboxyfluorescein diacetate succinimidyl ester (CFSE) method, and islet function test using the sugar stimulation test. Results showed that Th17 counts increased in the co-culture system. However, after administration of IL-35, the number of Treg cells increased significantly compared to that in the control group (50.7% of total CD4+ T cells on day 5 in IL-35 group vs. 9.5% in control group) whereas the proliferation rate of Th17 cells was significantly inhibited (0.3% in IL-35 group vs. 7.2% in control group on day 5). Reducing the Th17/Treg ratio significantly improved the function of transplanted islets. Treg inhibited Th17 proliferation and IL-35 enhanced this inhibitory effect. IL-35 mitigates the function of murine transplanted islet cells via regulation of the Treg/Th17 ratio. This might serve as a potential therapeutic strategy for in-vivo islet transplant rejection and T1D.

https://www.semanticscholar.org/paper/4a3e17f36aef6933bc4cc88cdac4076d5210a7e1

Effect of phenylbutazone on insulin secretion in horses with insulin dysregulation

Journal of Veterinary Internal Medicine

d9f5053c-a9db-4874-9131-2d2e304206cc

Effect of phenylbutazone on insulin secretion in horses with insulin dysregulation Abstract Background Phenylbutazone is often prescribed to manage pain caused by hyperinsulinemia‐associated laminitis, but in diabetic people nonsteroidal anti‐inflammatory drugs increase insulin secretion and pancreatic activity. Hypothesis/Objectives Investigate the effect of phenylbutazone administration on insulin secretion in horses. It was hypothesized that phenylbutazone will increase insulin secretion in horses with insulin dysregulation (ID). Animals Sixteen light breed horses, including 7 with ID. Methods Randomized cross‐over study design. Horses underwent an oral glucose test (OGT) after 9 days of treatment with phenylbutazone (4.4 mg/kg IV q24h) or placebo (5 mL 0.9% saline). After a 10‐day washout period, horses received the alternative treatment, and a second OGT was performed. Insulin and glucose responses were compared between groups (ID or controls) and treatments using paired t test and analyses of variance with P < .05 considered significant. Results In horses with ID, phenylbutazone treatment significantly decreased glucose concentration (P = .02), glucose area under the curve (2429 ± 501.5 vs 2847 ± 486.1 mmol/L × min, P = .02), insulin concentration (P = .03) and insulin area under the curve (17 710 ± 6676 vs 22 930 ± 8788 μIU/mL × min, P = .03) in response to an OGT. No significant effect was detected in control horses. Conclusion and Clinical Importance Phenylbutazone administration in horses with ID decreases glucose and insulin concentrations in response to an OGT warranting further investigation of a therapeutic potential of phenylbutazone in the management of hyperinsulinemia‐associated laminitis beyond analgesia.

https://www.semanticscholar.org/paper/248c9fa66d53e72f97b0c245203e7a7a807bcc0a

Retracted: Clinical Efficacy of Ulinastatin Combined with Meglumine Adenosine Cyclophosphate in the Treatment of Acute Myocardial Infarction

Computational and Mathematical Methods in Medicine

2ca1e2ac-8c3b-4251-94ed-24846d391d3b

Retracted: Clinical Efficacy of Ulinastatin Combined with Meglumine Adenosine Cyclophosphate in the Treatment of Acute Myocardial Infarction .

https://www.semanticscholar.org/paper/1799070a56a878d4c27face2ee89510e2507525a

Comparative Evaluation of Efficacy of Protaper Universal Retreatment System, R-Endo System and Hedstrom File in Gutta Percha Removal During Root Canal Retreatment- An In Vitro Study

Journal of Pharmacy and Bioallied Sciences

78f0693c-2254-425e-9816-0af30e467821

Comparative Evaluation of Efficacy of Protaper Universal Retreatment System, R-Endo System and Hedstrom File in Gutta Percha Removal During Root Canal Retreatment- An In Vitro Study Background: The complete removal of residual filling materials from the root canal determines the success of root canal retreatment. Aim: To evaluate and correlate the efficacy of ProTaper retreatment system, R-Endo retreatment system, and Hedstrom file in the removal of gutta-percha and sealer from root canal during endodontic retreatment in addition to the period desired for the elimination of gutta-percha and sealer. Methodology: Thirty extracted premolars were prepared and filled by cold lateral compaction with gutta-percha and sealer. Retreatment was finished with ProTaper retreatment files, R-Endo files, Hedstrom files with Endosolv E as the solvent for 10 specimens each. Each half of the root was imaged using the image analyzer software Chroma allied to a stereomicroscope with 10× magnification via a charge-coupled device sensor. For statistical analysis, parametric one-way ANOVA test and Scheffe post hoc multiple range test were utilized at a significance level of P < 0.05. Results: There is no significant difference among the three groups at P < 0.0001 in removing filling material. However, the rotary files needed significantly less time for removing gutta-percha along with sealer than H-file (P < 0.0001). Conclusion: The gutta-percha and sealer were found in the root canal subsequent to all the retreatment techniques, especially in the apical third. Retreatment time was less only for the rotary system.

https://www.semanticscholar.org/paper/eb1293244fed6a2983e70aee5aa51f70274ecbae

Correction: Evaluating the role of land cover and climate uncertainties in computing gross primary production in Hawaiian Island ecosystems

PLoS ONE

0aed7a40-85f3-4c66-9e1b-c1556c57001b

Correction: Evaluating the role of land cover and climate uncertainties in computing gross primary production in Hawaiian Island ecosystems .

https://www.semanticscholar.org/paper/8a6a8a2857164fd0f8d568c3fce87beabc15c32a

Molecular mechanisms and evolutionary robustness of a color switch in proteorhodopsins

Science Advances

cb30f0c9-2980-4b7d-bbcb-68fc5472b97c

Molecular mechanisms and evolutionary robustness of a color switch in proteorhodopsins Proteorhodopsins are widely distributed photoreceptors from marine bacteria. Their discovery revealed a high degree of evolutionary adaptation to ambient light, resulting in blue- and green-absorbing variants that correlate with a conserved glutamine/leucine at position 105. On the basis of an integrated approach combining sensitivity-enhanced solid-state nuclear magnetic resonance (ssNMR) spectroscopy and linear-scaling quantum mechanics/molecular mechanics (QM/MM) methods, this single residue is shown to be responsible for a variety of synergistically coupled structural and electrostatic changes along the retinal polyene chain, ionone ring, and within the binding pocket. They collectively explain the observed color shift. Furthermore, analysis of the differences in chemical shift between nuclei within the same residues in green and blue proteorhodopsins also reveals a correlation with the respective degree of conservation. Our data show that the highly conserved color change mainly affects other highly conserved residues, illustrating a high degree of robustness of the color phenotype to sequence variation.

https://www.semanticscholar.org/paper/eff19b11ddf946d180c9c7d5d7867811a743e82a

Erratum: Correction of Ethics Statement: Discordance between Physician and the General Public Perceptions of Prognostic Disclosure to Children with Serious Illness: a Korean Nationwide Study

Journal of Korean medical science

234eed58-91c0-4682-ac5e-2a86d6d3acdc

Erratum: Correction of Ethics Statement: Discordance between Physician and the General Public Perceptions of Prognostic Disclosure to Children with Serious Illness: a Korean Nationwide Study .

https://www.semanticscholar.org/paper/040d78804090b62f21b7c462629eccc90129aada

Evaluation of levetiracetam as a pre-operative anxiolytic: A randomized, double-blind, placebo-controlled study

Indian Journal of Anaesthesia

38d0873f-b21e-4365-b630-42c46122e640

Evaluation of levetiracetam as a pre-operative anxiolytic: A randomized, double-blind, placebo-controlled study Pre-operative anxiety has been described as a subjective feeling of apprehension, fear, and nervousness. Many pharmacological and non-pharmacological methods have been used to allay anxiety in the pre-operative period. Anticonvulsants such as gabapentin and pregabalin are used effectively to attenuate pre-operative anxiety. Levetiracetam that is a novel antiepileptic drug has also shown anxiolysis property in various studies. To date, no clinical study has evaluated the efficacy of levetiracetam in reducing pre-operative anxiety. We conducted this study to assess the effects of levetiracetam on attenuating pre-operative anxiety.

https://www.semanticscholar.org/paper/17851cb50e8425651be1f72a884e3c9a71548db1

Correction: Neural Activity During Audiovisual Speech Processing: Protocol For a Functional Neuroimaging Study

JMIR Research Protocols

278131df-030d-4e6c-b083-d57f3b740dc4

Correction: Neural Activity During Audiovisual Speech Processing: Protocol For a Functional Neuroimaging Study .

https://www.semanticscholar.org/paper/e2f0fc44cc8cb82155135c94b526b4489b1ebddb

Deprescribing Blood Pressure Treatment in VA Long-Term Care Residents

Innovation in aging

6d6a372b-cc95-4ba3-85d8-165d6d96da48

Deprescribing Blood Pressure Treatment in VA Long-Term Care Residents Abstract There is growing interest in deprescribing of antihypertensive medications in response to adverse effects, or when a patient’s situation evolves such that the benefits are outweighed by the harms. We conducted a retrospective cohort study to evaluate the incidence and predictors of deprescribing of antihypertensive medication among VA long-term care residents ≥ 65 years admitted between 2006 and 2017. Data were extracted from the VA electronic health record, CMS Minimum Data Set, and Bar Code Medication Administration. Deprescribing was defined as a reduction in the number of antihypertensive medications, sustained for 2 weeks. Potentially triggering events for deprescribing included low blood pressure (<90/60 mmHg), acute renal impairment (creatinine increase of 50%), electrolyte imbalance (potassium below 3.5 mEq/L, sodium decrease by 5 mEq/L), and fall in the past 30 days. Among 22,826 VA nursing home residents on antihypertensive medication, 57% had describing event during their stay (median length of stay = 6 months). Deprescribing events were most common in the first 4 weeks after admission and the last 4 weeks of life. Among potentially triggering events, acute renal impairment was associated with greatest increase in the likelihood of deprescribing over the subsequent 4 weeks: among residents with this event, 32.7% were described compared to 7.3% in those without (risk difference = 25.5%, p<0.001). Falls were associated with the smallest increased risk of deprescribing (risk difference = 2.1%, p<0.001) of the events considered. Deprescribing of antihypertensive medications is common among VA nursing home residents, especially after a potential renal adverse event.

https://www.semanticscholar.org/paper/930500c6641313ed739d5a5b6b15d7c6fc2b5369

A Cross-Sectional Study on the Effect of Chronic Noise Exposure on the Vestibular Function of Traffic Policemen and Automobile Drivers

Noise and Health

1e089ba0-8bed-4bc0-a768-738800fe9153

A Cross-Sectional Study on the Effect of Chronic Noise Exposure on the Vestibular Function of Traffic Policemen and Automobile Drivers Abstract Introduction: Noise is a preventable occupational hazard for certain professions like automobile drivers and traffic police personnel. The harmful auditory effects of noise are well known. However, little is known about the status of the vestibular function in chronic noise exposure without noise induced hearing loss. Our objective was to assess the vestibular function in chronic noise exposure. Methodology: The study was conducted with a sample size of 242 (chronic noise exposure group − 121, group without chronic noise exposure − 121). Noise estimation was carried out across various traffic intersections to assess the noise exposure levels of the exposed group. All participants underwent a detailed vestibular evaluation in the clinical vestibulometry laboratory. Results: There was no difference in nystagmus, saccades, caloric function between the two groups. The latency and amplitude of vestibular evoked myogenic potentials (VEMP) were similar in both the groups. However, dynamic posturography showed a significant difference in the Adaptation test between the two groups (P < 0.05). We also found a statistically significant difference between the static and dynamic subjective visual vertical (SVV) and the dynamic visual acuity (DVA) between the two groups (P < 0.05). Conclusion: We did not find any clinical evidence of vestibular dysfunction in the noise exposed group. However, the statistical significance of SVV and DVA as seen in this study needs to be evaluated further as an early marker for vestibular dysfunction. It remains to be seen whether the statistically significant prolongation is reversible after the noise exposure is withdrawn.

https://www.semanticscholar.org/paper/e3f4260d3a98735ba45902a2569d48551b476991

A computerized doughty predictor framework for corona virus disease: Combined deep learning based approach

IET Image Processing

409a4f56-7785-415a-8fa6-32fde080b401

A computerized doughty predictor framework for corona virus disease: Combined deep learning based approach Abstract Due to a technical error, the following article was published in error on Wiley Online Library as an Accepted Article on 5 December 2022. The article has been temporarily removed. Wiley would like to apologize to the authors and the academic community for this error. Ramya, P. and Babu, S.V. (2022), A computerized doughty predictor framework for corona virus disease: Combined deep learning based approach. IET Image Process. Accepted Author Manuscript.

https://www.semanticscholar.org/paper/3b6b82b246bff944412259e03a8c9892a1c4bc86

Correction to: “Endogenous Diurnal Patterns of Adrenal and Gonadal Hormones During a 24-Hour Constant Routine After Simulated Shift Work”

Journal of the Endocrine Society

ccbeb193-d73e-4c27-9e78-65553fb9c08a

Correction to: “Endogenous Diurnal Patterns of Adrenal and Gonadal Hormones During a 24-Hour Constant Routine After Simulated Shift Work” .

https://www.semanticscholar.org/paper/2f841d9197a9568d7837c2499219212d375a1975

Prognostic impact of fluorescent lymphography on gastric cancer

International Journal of Surgery

b181ba74-e507-4d46-a2f9-d2ae419d7151

Prognostic impact of fluorescent lymphography on gastric cancer Background: Fluorescent lymphography-guided lymphadenectomy (FL) for gastric cancer is gaining popularity. However, its impact on prognosis is not known. This study aimed to assess the prognostic impact of FL in gastric cancer patients. Materials and methods: This study retrospectively analyzed 5678 gastric cancer patients who underwent gastrectomy from 2013 to 2017. The survival was compared between the FLFL group and the conventional lymphadenectomy (non-FL group) using 1:1 propensity score matching after exclusion. Patients in the FL group underwent gastrectomy with systematic lymphadenectomy after endoscopic peritumoral injection of indocyanine green the day before surgery. Results: After propensity score matching, the FL and non-FL groups each had 1064 patients with similar demographic and clinicopathological characteristics. All matched variables had a standardized mean difference under 0.1. The FL group showed a significantly higher number of retrieved lymph nodes (56.2±20.1) than the non-FL group (46.2±18.2, P<0.001). The FL group also had more stage III patients (P=0.044) than the non-FL group. The FL group demonstrated higher overall survival (P=0.038) and relapse-free survival (P=0.036) in stage III compared with the non-FL group. However, no significant differences in overall and relapse-free survival were observed between the two groups for stages I (P=0.420 and P=0.120, respectively) and II (P=0.200 and P=0.280, respectively). Conclusion: FL demonstrated a higher survival in stage III gastric cancer patients by the more accurate staging resulting from larger lymph node retrieval. Thus, given its potential to improve prognostication by enhancing staging accuracy, it is recommended as an option to consider the use of FL in clinical practice.

https://www.semanticscholar.org/paper/0ea8e4b506b586e75b48b03977d28cf87c6d62f4

Academic practice in ecology and evolution: Soliciting a new category of manuscript

Ecology and Evolution

e940bdf3-601c-415d-95ed-9c0197737d03

Academic practice in ecology and evolution: Soliciting a new category of manuscript We are excited to announce a new category of paper: “Academic Practice in Ecology and Evolution.” As ecologists and evolutionary biologists, we apply scholarly approaches to the myriad roles we have undertaken in our professions. Publishing about such new knowledge and advances in our ‘roles’ (e.g., teaching, service, outreach, professional development, and change) typically occurs in a range of transdisciplinary journals. Tracking down this literature, in what can be disparate fields of research, is timeconsuming and can prevent groundbreaking ideas from being more generally acknowledged and ultimately implemented in the daytoday. Our new category “Academic Practice” is intended to remedy this situation and bring highquality studies in the following broad categories to the attention of our readers:

https://www.semanticscholar.org/paper/baee2be32cc1c7c5580f41e0ede432ec40caf122

Progress in General Surgery

The Hospital

965d752e-3d99-47a6-bf0f-de96ba26b1f3

Progress in General Surgery Fractures and Dislocations.?Upper Extremity.? A very rare instance of fracture through, the neck of the scapula .is reported by Dr. J. Brown.10 The arm was an inch longer than its fellow, and there was flattening over the deltoid with marked prominence of the acromion. The deformity disappeared on pulling the elbow upwards, while rotation of the arm elicited distinct crepitus. On allowing the' arm to hang the deformity disappeared. Pressure over the coracoid caused pain with reappearance of the deformity, and this process could be moved independently of the scapula. Under either the parts were accurately adjusted, and the arm strapped to the side over a firm pad in the axilla. The arm was well supported under the elbow and across the opposite shoulder by strapping, flannel, and plaster bandages. Union was perfect. In reporting two cases of unreduced dislocation of the elbow Loison 11 says that no treatment short of partial resection can have any good result. Passive movement, massage, subcutaneous section of fibrous

https://www.semanticscholar.org/paper/f4193ce2f87dae49bc5b688462c023428082ed0b

Tobacco Use Among Working Adults — United States, 2014–2016

MMWR. Morbidity and mortality weekly report

Tobacco Use Among Working Adults — United States, 2014–2016 Cigarette smoking has declined considerably among U.S. adults over several decades (1); however, increases have occurred in the use of noncigarette tobacco products in recent years, and the use of multiple tobacco products has become common among current users of noncigarette tobacco products (2,3). Differences in tobacco use have also been observed across population subgroups, including among working adults (2,4). CDC analyzed National Health Interview Survey (NHIS) data for 2014-2016 to describe the most recent prevalence estimates of current (every day or some days) tobacco product use among working U.S. adults by industry and occupation. Among working adults, 22.1% (32.7 million) currently used any form of tobacco; 15.4% used cigarettes, 5.8% used other combustible tobacco (cigars, pipes, water pipes or hookahs, very small cigars, and bidis), 3.0% used smokeless tobacco, and 3.6% used electronic cigarettes (e-cigarettes); 4.6% (6.9 million) reported current use of two or more tobacco products. By industry, any tobacco use ranged from 11.0% among education services to 34.3% among construction workers; current use of two or more tobacco products was highest among construction workers (7.1%). By occupation, any tobacco use ranged from 9.3% among life, physical, and social science workers to 37.2% among installation, maintenance, and repair workers; current use of two or more tobacco products was highest among installation, maintenance, and repair workers (10.1%). Proven interventions to prevent and reduce tobacco product use, including current use of multiple products, among working adults are important (5,6). Workplace tobacco-control interventions have been especially effective in reducing cigarette smoking prevalence (7).

https://www.semanticscholar.org/paper/58923a27dd699d359b3b94c4c960512085ae654d

Dams trigger exponential population declines of migratory fish

Science Advances

cb30f0c9-2980-4b7d-bbcb-68fc5472b97c

Dams trigger exponential population declines of migratory fish The impact of dams on global migratory fish stocks is a major challenge and remains seriously underestimated. China has initiated a dozen fish rescue programs for the dams on the Yangtze River, focusing on five flagship species―Chinese sturgeon, Chinese paddlefish, Yangtze sturgeon, Chinese sucker, and Coreius guichenoti. Despite 40 years of effort, these five fishes are on the verge of extinction. Here, we propose an analytical tool that includes a framework of fish migration taxonomy and six life cycle models, the concepts of invalid stock and the dam impact coefficient, and a simplified population model. We then clarify the migration patterns and life cycles of these fishes and show that the Yangtze dams have severely disrupted the life cycle integrity of these species, causing seven types of invalid stocks and their exponential population declines. Last, we discuss six scientific misjudgments underpinning the fish rescue programs and recommend reforms to China’s fish rescue strategy.

https://www.semanticscholar.org/paper/3d778110987723e97e9546c75d2501a2a67567a3

Correction: Estimates of air pollution in Delhi from the burning of firecrackers during the festival of Diwali

PLoS ONE

0aed7a40-85f3-4c66-9e1b-c1556c57001b

Correction: Estimates of air pollution in Delhi from the burning of firecrackers during the festival of Diwali .

https://www.semanticscholar.org/paper/ed85261067c28abbf9a2fdccc8d61b9eb3db018c

Atlas of the I2 Spectrum from 19 000 to 18 000 cm−1

Journal of Research of the National Bureau of Standards Section A Physics and Chemistry

437d0291-70b6-46c2-9135-1f0753dadf1d

Atlas of the I2 Spectrum from 19 000 to 18 000 cm−1 A line identification band atlas is presented for a 1000 cm−1 segment, from 19 000 to 18 000 cm−1, of the molecular iodine absorption spectrum. Each page of the atlas covers a 20 cm−1 region of the spectrum and contains a CALCOMP produced photodensitometer trace of the spectrum together with accompanying tabular identification data. The tabular data includes: line identification numbers, observed wavenumbers, calculated wavenumbers, and rotational and vibrational assignments.

https://www.semanticscholar.org/paper/7f74d15d815ced23dde13637936b7eb778a53895

Dose‐Response Carcinogenicity in Rats on Low‐dose Levels of N‐Ethyl‐N‐nitrosourethane

Japanese journal of cancer research : Gann

Dose‐Response Carcinogenicity in Rats on Low‐dose Levels of N‐Ethyl‐N‐nitrosourethane A dose‐response study on the carcinogenicity of N‐ethyl‐N‐nitrosourethane (ENUR) was undertaken to examine its effect at low doses. Six‐week‐old female F344 rats were divided into 5 groups, each consisting of 40 animals. ENUR was dissolved in distilled water at dose levels of 0 (control), 0.15, 0.6, 2.5 and 10 ppm, and rats were given these solutions ad libitum for 2 years. Significant increase of the total tumor incidences and shortening of the mean survival times were observed in groups given 2.5 and 10 ppm ENUR. In groups given 0.6 ppm or more ENUR, digestive tract tumors were induced dose‐dependently. They were restricted to the upper digestive tract from the oral cavity to the forestomach, and were histologically squamous cell papillomas or carcinomas. Dose‐related differences in the location and incidence of these tumors were found. The virtually safe doses (VSDs) calculated by using the Weibull, Logit and Probit models were 0.365 × 10‐2, 0.110 × 10‐1 and 0.779 × 10‐1 ppm, respectively. The VSDs estimated in the present study are discussed in comparison with those of other carcinogens.

https://www.semanticscholar.org/paper/dd9ac78020e103e4295c86409c8681fe49920c88

The impact of life-long strength versus endurance training on muscle fiber morphology and phenotype composition in older men

Journal of applied physiology

c1910748-cf51-4346-9f09-55d2a5775843

The impact of life-long strength versus endurance training on muscle fiber morphology and phenotype composition in older men Aging is typically associated with decreased muscle strength and rate of force development (RFD), partly explained by motor unit remodeling due to denervation, and subsequent loss of fast-twitch type II myofibers. Exercise is commonly advocated to counteract this detrimental loss. However, it is unclear how life-long strength- versus endurance-training may differentially affect markers of denervation and reinnervation of skeletal myofibers and, in turn, affect the proportion and morphology of fast-twitch type II musculature. Thus, we compared fiber type distribution, fiber type grouping, and the prevalence of atrophic myofibers (≤1494µm2) in strength-trained (OS) versus endurance-trained (OE) master athletes and compared the results to recreationally active older adults (all >70yr, OC) and young habitually active references (<30yr, YC). Immunofluorescent stainings were performed on biopsy samples from vastus lateralis, along with leg press maximal strength and RFD measurements. OS demonstrated similar type II fiber distribution (OS:52.0±16.4%; YC:51.1±14.4%), fiber type grouping, maximal strength (OS:170.0±18.9kg, YC:151.0±24.4kg), and RFD (OS:3993±894N‧s-1, YC:3470±1394N‧s-1) as young, and absence of atrophic myofibers (OS:0.2±0.7%; YC: 0.1±0.4%). In contrast, OE and OC exhibited more atrophic fibers (OE:1.2±1.0%; OC: 1.1±1.4%), more grouped fibers, and smaller proportion of type II fibers (OE:39.3±11.9%; OC: 35.0±12.4%) than OS and YC (all p<0.05). In conclusion, strength-trained master athletes were characterized by similar muscle morphology as young, which was not the case for recreationally active or endurance-trained old. These results indicate that strength training may preserve type II fibers with advancing age in older men, likely as a result of chronic use of high contractile force generation.

https://www.semanticscholar.org/paper/bb190a849672d974cc79206eebfa8932a1f97c59

Identification of key genes and molecular mechanisms of chronic urticaria based on bioinformatics

Skin research and technology

20e167cb-8aa4-4802-8fff-e2513b655f86

Identification of key genes and molecular mechanisms of chronic urticaria based on bioinformatics Chronic urticaria (CU) is characterized by persistent skin hives, redness, and itching, enhanced by immune dysregulation and inflammation. Our main objective is identifying key genes and molecular mechanisms of chronic urticaria based on bioinformatics. We used the Gene Expression Omnibus (GEO) database and retrieved two GEO datasets, GSE57178 and GSE72540. The raw data were extracted, pre‐processed, and analyzed using the GEO2R tool to identify the differentially expressed genes (DEGs). The samples were divided into two groups: healthy samples and CU samples. We defined cut‐off values of log2 fold change ≥1 and p < .05. Analyses were performed in the Kyoto Encyclopaedia of Genes and Genomes (KEGG), the Database for Annotation, Visualization and Integrated Discovery (DAVID), Metascape, Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and CIBERSOFT databases. We obtained 1613 differentially expressed genes. There were 114 overlapping genes in both datasets, out of which 102 genes were up‐regulated while 12 were down‐regulated. The biological processes included activation of myeloid leukocytes, response to inflammations, and response to organic substances. Moreover, the KEGG pathways of CU were enriched in the Nuclear Factor‐Kappa B (NF‐kB) signaling pathway, Tumor Necrosis Factor (TNF) signaling pathway, and Janus kinase/signal transducers and activators of transcription (JAK‐STAT) signaling pathway. We identified 27 hub genes that were implicated in the pathogenesis of CU, such as interleukin‐6 (IL‐6), Prostaglandin‐endoperoxide synthase 2 (PTGS2), and intercellular adhesion molecule‐1 (ICAM1). The complex interplay between immune responses, inflammatory pathways, cytokine networks, and specific genes enhances CU. Understanding these mechanisms paves the way for potential interventions to mitigate symptoms and improve the quality of life of CU patients.

https://www.semanticscholar.org/paper/8bd52a95e10ed947bac75ef91fbb9a53fed04584

Critical Documents on Cow's Milk Allergy and Anaphylaxis: Two Recent WAO Position Papers

The World Allergy Organization Journal

306ec33f-006e-45ef-8992-4bbbfba6f4ea

Critical Documents on Cow's Milk Allergy and Anaphylaxis: Two Recent WAO Position Papers The purpose of this editorial is to highlight the recent ratification as WAO Position Papers of 2 important documents published in the World Allergy Organization Journal (WAO Journal). The "World Allergy Organization (WAO) Guidelines on the Diagnosis and Rationale against Cow's Milk Allergy (DRACMA) Guidelines," ratified as a WAO Position Paper by the WAO House of Delegates, March 21, 2011, involves a significant pediatric food allergy problem and provides invaluable guidelines for the clinician. This impressive collection of information on this worldwide problem will help in the management of cow's milk allergy, which has profound implications for growth and development and the health of children worldwide. Under the able leadership of Professor Alessandro Fiocchi (Italy), the Chair of the WAO Special Committee on Food Allergy, an international group has put together a scholarly and well-appointed review of all the issues related to cow's milk allergy (CMA), ranging from methodology and epidemiology through a variety of other aspects of the clinical syndrome. DRACMA provides the guidelines for diagnosing CMA, and the proper natural history treatment alternatives ranging from avoidance through identification of milk derived from a variety of other sources, including unusual sources, which can be used for dietary supplementation. DRACMA employed evidence-based methodology utilizing the criteria of Grading of Recommendations Assessment, Development and Evaluation (GRADE) in its analysis of the literature. "World Allergy Organization Guidelines for the Assessment and Management of Anaphylaxis," the WAO Position Paper ratified on February 18, 2011, is a thorough, extensive work completed by worldwide anaphylaxis and allergy experts of the WAO Special Committee on Anaphylaxis led by Chair, Professor F. Estelle Simons. In addition to clearly defining, in a concise manner, the syndrome, its severity, and the possibility for treatment, the document has also provided a very clear and detailed management plan for acute anaphylaxis in both high- and low-resource areas. This is an important stride forward and the WAO Journal as always looks to better care for allergy sufferers at risk for anaphylaxis and for significant morbidity and mortality. This position paper is an excellent resource to help those circumstances. The Position Paper series within the WAO Journal is intended to address the needs of the profession worldwide. Along with the 2 most recent documents, and another on the state of sublingual immunotherapy (SLIT), the series also includes a treatise on defining an allergist, basic qualities of an allergist, training required for allergists, and educational requirements--all to impart allergy education to students, residents, and practitioners. The WAO and the WAO Journal will continue to invest in the development and identification of guidelines for treating important, clinically relevant syndromes associated with allergic disease such as cow's milk allergy or anaphylaxis. The recently ratified position papers and other WAO documents published in WAO Journal can be accessed in the following linked list of titles: • World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines • World Allergy Organization Guidelines for the Assessment and Management of Anaphylaxis • Sub-Lingual Immunotherapy: World Allergy Organization Position Paper 2009 • Recommendations for Competency in Allergy Training for Undergraduates Qualifying as Medical Practitioners: A Position Paper of the World Allergy Organization • Requirements for Physician Competencies in Allergy: Key Clinical Competencies Appropriate for the Care of Patients With Allergic or Immunologic Diseases: A Position Statement of the World Allergy Organization • What Is an Allergist?: Reconciled Document Incorporating Member Society Comments, September 3, 2007

https://www.semanticscholar.org/paper/3d5f35a4bf1d9a3d951e2989e7a1cd29be9c2a28

An Association of Patients

Mental health

An Association of Patients Association of Patients on the lines of the Diabetic Association for those who have gone through Mental Hospitals and have recovered ? This would be in no way connected with bodies which aim at revealing the defects in institutional treatment, and expressions of regret about what had happened in the past would be barred. The Association would aim at producing a hopeful and constructive outlook on the future by mutual encouragement and by the enlightenment which might come from the patients' point of view stated objectively. It is to be hoped that it would include medical men. At present those of us who have been in hospitals for mental treatment in the past, have to overcome a sense of shame in admitting this fact. It is difficult to retain faith in our own personality, particularly if we have to express views which are not widely held. Though there has been some progress in educating public opinion by societies such as the N.A.M.H., there is still an attitude towards mental illness which sets it apart from all physical ailments to the detriment of healing processes.

https://www.semanticscholar.org/paper/9f986ff085824fd73d47ae68bf2e329cea6fe97f

Chinese Medical Personnel: Better Sleep Hygiene Needed

Iranian Journal of Public Health

79f8265a-b1f5-4e2f-b21d-18fba684f0dd

Chinese Medical Personnel: Better Sleep Hygiene Needed China is facing a furious fight to the sleep problem of people in this country. As a specific group, Chinese Medical Personnel should have been given urgent attention. Medical system reform is still a challenge for the Chinese government. At the same time of protecting the legal rights and interests of the medical staff, how to keep their mentally and physically fit during their long career will be an important topic. According to the 2015 China Sleep Quality Index, not only has the number of Chinese suffering from insomnia increased, but also they are going to bed later and later. In today's China, it is still under population pressure, lack of medical workers and the enormous imbalance in medical resource distribution is obvious. The medical personnel's professional sense of honor declined and the doctor-patient relationship becomes more estranged. China Sleep Quality Index published last year by the Chinese Medical Doctor Association reported more than 30% of Chinese residents failed the sleep quality and the medical personnel posted the lowest scores (1). Chinese Psychiatrist Association also has conducted a survey in 2007, involved 2759 doctors from 30 hospitals, aged between 30 ~ 40 years old, which showed that 1914 doctors had sleep disorders (2). The Chinese front-line clinical medical staff often works overtime and has night shifts frequently. Chinese Analysis Report of National Health Services Survey in 2008 shows that medical workers averaging 50.6 hours a week, far more than 40 hours a week of the legal work time, and some staff even have 6 night shifts per month on average (3). Frequent shift work forces medical staff to change their normal schedules, interferes with biological rhythms, social activities and family life and reduces efficiency, increases the probability of errors, easily leads to the occurrence of metabolic syndrome. In South Korea (4), evening chronotype was independently associated with diabetes, metabolic syndrome in an epidemiological sense. The medical staff aged over 40 from a hospital the prevalence rate of metabolic syndrome was 13.75% (5). 9.17% in 1996 medical staff medical personnel suffer metabolic syndrome (6). Medical system reform is still a challenge for the Chinese government. At the same time of protecting the legal rights and interests of the medical staff, how to keep their mentally and physically fit during their long career will be an important topic. Acknowledgements The authors declare that there is no conflict of interests.

https://www.semanticscholar.org/paper/2591c6f7068d02477ef493af5c186275320a725b

Associations between Serotonergic Genes and Escitalopram Treatment Responses in Patients with Depressive Disorder and Acute Coronary Syndrome: The EsDEPACS Study

Psychiatry Investigation

a30b60d8-8a5b-42a4-b504-5fca84f64f73

Associations between Serotonergic Genes and Escitalopram Treatment Responses in Patients with Depressive Disorder and Acute Coronary Syndrome: The EsDEPACS Study Genes related to serotonin are associated with responses to treatment for depression. We examined associations between the serotonin transporter (5-HTT) and serotonin 2a receptor (5-HTR2a) genes and responses to treatment for depressive disorders in acute coronary syndrome (ACS). A total of 255 patients who met the DSM-IV major or minor depressive disorder and recently developed ACS were randomly assigned to the escitalopram (n=127) or placebo (n=128) group in this 24-week double-blind trial (ClinicalTrial.gov identifier: NCT00419471). Remission was defined as a Hamilton Rating Scale for Depression (HAMD) score ≤7. Assays were performed for the 5-HTTLPR, STin2 VNTR, 5-HTR2a 102T/C, and 5-HTR2a 1438A/G genotypes. Escitalopram was superior to placebo for treating depressive disorder with ACS but there were no significant associations between serotonergic genes and treatment responses even when considering ACS severity. The effect of escitalopram was independent of 5-HTT and 5-HTR2a polymorphisms.

https://www.semanticscholar.org/paper/6c72d41c1528ba5f77734a17d4e159277a0fa176

Evaluation of Salivary Alkaline Phosphatase and Glutathione Peroxidase Levels in Diabetic and Nondiabetic Participants With and Without Smoking Habits: A Case–Control Study

Journal of Pharmacy and Bioallied Sciences

78f0693c-2254-425e-9816-0af30e467821

Evaluation of Salivary Alkaline Phosphatase and Glutathione Peroxidase Levels in Diabetic and Nondiabetic Participants With and Without Smoking Habits: A Case–Control Study Background: The majority of the current evidence suggests that tobacco smoking increases the risk of diabetes. Salivary alkaline phosphatase (ALP) and glutathione peroxidase (GSHPx) considered a biomarker to detect various oral diseases. Several studies suggest that smoking habits tend to alter ALP and GSHPx levels. However, at present, there is no much information about these enzymes in smokers with diabetes. Hence, the study aimed to evaluate the status of salivary ALP and GSHPx levels in diabetic and nondiabetic participants with and without smoking habits. Materials and Methods: This case–control study was approved by the Institutional Ethical Committee. A total of 60 male participants between the age group 35–50 years were recruited. Informed consent was obtained from participants. Participants were categorized into four groups: Group I – Smokers with diabetes (n = 15), Group II – Smokers without diabetes (n = 15), Group III – Nonsmoker with diabetes (n = 15), and Group IV – Nonsmoker without diabetes (n = 15). Salivary ALP levels and GSHPx activity were measured by colorimetric assay. Data were compared between groups using the one-way analysis of variance, followed by a Bonferroni post-hoc test. Results: Nonsmoker diabetic participants demonstrated significantly higher ALP levels as compared to other groups (P < 0.05). We observed significantly lower levels of ALP in smokers with diabetes (P < 0.05). We observed a significant decrease in GSHPx activity in smokers with diabetes compared to all other groups (P < 0.05). Conclusions: Salivary ALP can be used as a clinical biomarker to be correlated for evaluating diabetes. GSHPx activity can be used to understand the response of supplementation therapy in smokers with diabetes.

https://www.semanticscholar.org/paper/5d8f360bee690c926e49ce26243190218f38da63

A Methodology to Objectively Assess the Performance of Sound Field Amplification Systems Demonstrated Using 50 Physical Simulations of Classroom Conditions

Noise and Health

1e089ba0-8bed-4bc0-a768-738800fe9153

A Methodology to Objectively Assess the Performance of Sound Field Amplification Systems Demonstrated Using 50 Physical Simulations of Classroom Conditions Introduction: The effect of a sound reinforcement system, in terms of speech intelligibility, has been systematically determined under realistic conditions. Different combinations of ambient and reverberant conditions representative of a classroom environment have been investigated. Materials and Methods: By comparing the measured speech transmission index metric with and without the system in the same space under different room acoustics conditions, it was possible to determine when the system was most effective. A new simple criterion, equivalent noise reduction (ENR), was introduced to determine the effectiveness of the sound reinforcement system which can be used to predict the speech transmission index based on the ambient sound pressure and reverberation time with and without amplification. Results: This criterion had a correlation, R2 > 0.97. It was found that sound reinforcement provided no benefit if the competing noise level was less than 40 dBA. However, the maximum benefit of such a system was equivalent to a 7.7 dBA noise reduction. Conclusion: Using the ENR model, it would be possible to determine the suitability of implementing sound reinforcement systems in any room, thus providing a tool to determine if natural acoustic treatment or sound field amplification would be of most benefit to the occupants of any particular room.

https://www.semanticscholar.org/paper/a8bed5595a908e6d039945e19c9690a64134a732

An unusual case of congenital hypertrophy of retinal pigment epithelium with overlying hemorrhages

Indian Journal of Ophthalmology

2bbc1e45-4074-471d-b003-2c8f5a99cdb0

An unusual case of congenital hypertrophy of retinal pigment epithelium with overlying hemorrhages A 24-year-old asymptomatic female was referred to the vitreoretina services in view of the presence of a pigmented lesion in the right eye. Fundus examination showed the presence of a solitary, hyperpigmented flat lesion with scalloped margins in the inferotemporal quadrant suggestive of congenital hypertrophy of retinal pigment epithelium (CHRPE). Scattered retinal hemorrhages were evident over the lesion . Fundus fluorescein angiography (FFA) showed blocked fluorescence due to pigment epithelial hypertrophy. A small retinal vein within the lesion showed segmented filling suggestive of sluggish flow. Areas of capillary dropout with leakage from smaller venules adjacent to the vein described above were seen . Spectral domain optical coherence tomography (SD-OCT) of the lesion showed thickened hyper-reflective retinal pigment epithelium (RPE) with shadowing, attenuation of the overlying retinal layers, abruptly terminating outer layers at the edge of the lesion and irregular focal hyper-reflective areas in the inner retinal layers corresponding to intraretinal hemorrhages . The above features suggested CHRPE with small vein occlusion.

https://www.semanticscholar.org/paper/988ac7a2b822a97e00782c4c9243ba825fe07458

Lesion Sterilization Tissue Repair: A Review

Journal of Pharmacy and Bioallied Sciences

78f0693c-2254-425e-9816-0af30e467821

Lesion Sterilization Tissue Repair: A Review As part of lesion sterilization and tissue restoration (LSTR), treatment for primary molars affected by extensive periapical pathosis and extreme resorption entails the use of a triple antibiotic mixture in an appropriate medium. In-depth explanation of all components of LSTR is the main focus of this review of the literature.

https://www.semanticscholar.org/paper/e67b0f85186d449144b8711bdc36a27295253b94

Correction to: CIVIC ENGAGEMENT AMONG OLDER MIGRANTS IN EUROPE: EXAMPLES FROM FOUR EUROPEAN COUNTRIES

Innovation in aging

6d6a372b-cc95-4ba3-85d8-165d6d96da48

Correction to: CIVIC ENGAGEMENT AMONG OLDER MIGRANTS IN EUROPE: EXAMPLES FROM FOUR EUROPEAN COUNTRIES .

https://www.semanticscholar.org/paper/1f8b87f33bbb333d9d3b32d5c30d96d0afd2f389

Corrigenda: Cairns SD (2018) Deep-Water Octocorals (Cnidaria, Anthozoa) from the Galápagos and Cocos Islands. Part 1: Suborder Calcaxonia. ZooKeys 729: 1–46. https://doi.org/10.3897/zookeys.729.21779

ZooKeys

e6b4b075-7764-44f6-acaf-99f80f0532fb

Corrigenda: Cairns SD (2018) Deep-Water Octocorals (Cnidaria, Anthozoa) from the Galápagos and Cocos Islands. Part 1: Suborder Calcaxonia. ZooKeys 729: 1–46. .

https://www.semanticscholar.org/paper/e8f48cf5eb22832827a1cb138fb7f409be2963b7

IGLoo: Profiling the Immunoglobulin Heavy chain locus in Lymphoblastoid Cell Lines with PacBio High-Fidelity Sequencing reads

bioRxiv

027ffd21-ebb0-4af8-baf5-911124292fd0

IGLoo: Profiling the Immunoglobulin Heavy chain locus in Lymphoblastoid Cell Lines with PacBio High-Fidelity Sequencing reads New high-quality human genome assemblies derived from lymphoblastoid cell lines (LCLs) provide reference genomes and pangenomes for genomics studies. However, the characteristics of LCLs pose technical challenges to profiling immunoglobulin (IG) genes. IG loci in LCLs contain a mixture of germline and somatically recombined haplotypes, making them difficult to genotype or assemble accurately. To address these challenges, we introduce IGLoo, a software tool that implements novel methods for analyzing sequence data and genome assemblies derived from LCLs. IGLoo characterizes somatic V(D)J recombination events in the sequence data and identifies the breakpoints and missing IG genes in the LCL-based assemblies. Furthermore, IGLoo implements a novel reassembly framework to improve germline assembly quality by integrating information about somatic events and population structural variantions in the IG loci. We applied IGLoo to study the assemblies from the Human Pangenome Reference Consortium, providing new insights into the mechanisms, gene usage, and patterns of V(D)J recombination, causes of assembly fragmentation in the IG heavy chain (IGH) locus, and improved representation of the IGH assemblies.

https://www.semanticscholar.org/paper/07053fd949db9753db5a49039568d5c9e68bdb3a

Evaluation of serum 25‐hydroxyvitamin D, C‐reactive protein, and haptoglobin as biomarkers in dogs newly diagnosed with histoplasmosis

Journal of Veterinary Internal Medicine

d9f5053c-a9db-4874-9131-2d2e304206cc

Evaluation of serum 25‐hydroxyvitamin D, C‐reactive protein, and haptoglobin as biomarkers in dogs newly diagnosed with histoplasmosis Abstract Background Serum 25‐hydroxyvitamin (OH)D, C‐reactive protein (CRP), and haptoglobin are useful biomarkers in various infectious diseases and inflammatory disorders in dogs, but their utility in histoplasmosis is unknown. Objective Determine if serum 25(OH)D, CRP, and haptoglobin concentrations are different in dogs with histoplasmosis compared to healthy controls and whether serum globulin, albumin, CRP, or haptoglobin are associated with 25(OH)D concentration. Animals Twenty‐two client‐owned dogs (histoplasmosis, n = 12; controls, n = 10). Methods Prospective case‐control study. Dogs with histoplasmosis were categorized as pulmonary, disseminated, or gastrointestinal (GI) tract. Serum 25(OH)D was measured using modified high‐performance liquid chromatography (HPLC). Serum CRP and haptoglobin were measured with ELISA assays. Results Dogs with histoplasmosis were grouped as disseminated (n = 8) and GI tract (n = 4). No dogs had pulmonary tract involvement alone. Dogs with histoplasmosis (median, interquartile range ; 11.6 ng/mL, 16.8) had lower serum 25(OH)D concentrations than controls (35.7 ng/mL, 17.6; P < .001). Serum CRP and haptoglobin concentrations were higher in dogs with histoplasmosis (CRP: median, IQR; 63.5 mg/L, 37.1 and haptoglobin: 459.7 mg/dL, 419.6) than controls (CRP: 1.9 mg/L, 2; P < .001 and haptoglobin: 85.5 mg/dL, 106.7; P = .003). Serum 25(OH)D concentration was positively associated with fold change in serum albumin concentration (ρ = 0.77; P < .001), and negatively associated with fold change in serum globulin (ρ = −0.61; P = .003) and CRP concentrations (ρ = −0.56; P = .01). Conclusion and Clinical Importance Assay of serum 25(OH)D, CRP, and haptoglobin could have clinical value in dogs with histoplasmosis.

https://www.semanticscholar.org/paper/3b3d8917b1d702d1b68a43076c03585667382847

The evolving landscape of salivary gland tumors

Ca

7777b179-7a66-44e1-bcc7-b454f2057262

The evolving landscape of salivary gland tumors Salivary gland cancers are a rare, histologically diverse group of tumors. They range from indolent to aggressive and can cause significant morbidity and mortality. Surgical resection remains the mainstay of treatment, but radiation and systemic therapy are also critical parts of the care paradigm. Given the rarity and heterogeneity of these cancers, they are best managed in a multidisciplinary program. In this review, the authors highlight standards of care as well as exciting new research for salivary gland cancers that will strive for better patient outcomes.

https://www.semanticscholar.org/paper/7e360d2324535718e38caaa541303544ef0bb527

Association between clinically probable REM sleep behavior disorder and tetanus in dogs

Journal of Veterinary Internal Medicine

d9f5053c-a9db-4874-9131-2d2e304206cc

Association between clinically probable REM sleep behavior disorder and tetanus in dogs Background Abnormal sleep behavior has been reported in 5 dogs during recovery from tetanus. Hypothesis REM sleep behavior disorder (RBD) is a more common consequence of tetanus than previously reported in veterinary literature and easily confused for epileptic seizures. Animals Sixty‐one client‐owned dogs diagnosed with tetanus at 2 UK referral centers. Methods A retrospective review of medical records was combined with a questionnaire sent to owners of surviving dogs, to identify cases that developed clinically probable RBD and determine its clinical progression and effect on quality of life of affected dogs and their owners. Descriptive statistical evaluation was performed. Results Eleven dogs (18%) died or were euthanized before discharge. At least 46% surviving dogs developed abnormal “dream enactment” clinically consistent with RBD. Twitching, running, and vocalization were new sleep behaviors in 53, 80, and 60% of affected dogs. Clinically probable RBD was described as violent or “nightmare”‐like in 36% affected dogs, and like an epileptic seizure in 40% affected dogs. When trialed, antiepileptic medications were ineffective. Onset occurred before discharge in 25% cases. For dogs that developed clinically probable RBD postdischarge, onset occurred within 2 weeks of discharge in 77% dogs. Clinically probable RBD did not worsen in severity or frequency in any dog, and spontaneously resolved within 6 months in 43% cases. Conclusions and Clinical Importance Clinically probable RBD is a common sequel to canine tetanus with many clinical similarities to epileptic seizure activity. Owners should be made aware of its potential development and care taken to avoid misdiagnosis with epileptic seizure activity.

https://www.semanticscholar.org/paper/2e7a93ce8139482b4afaa51f6d5797dd2e648433

Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, lymphocyte to monocyte ratio and Systemic Inflammatory Index in sexually transmitted diseases

Medicine and Pharmacy Reports

a7a9bb88-1841-4875-97b9-4c254629e360

Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, lymphocyte to monocyte ratio and Systemic Inflammatory Index in sexually transmitted diseases Introduction Hematologic biomarkers of inflammation may serve as valuable adjuncts in clinical practice, aiding in several aspects such as differential diagnosis, prognostic assessment for patient stratification and monitoring the efficacy of antimicrobial therapy. The aim of this study was to evaluate the efficacy of Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR), Lymphocyte to Monocyte Ratio (LMR), and Systemic Inflammatory Index (SII) in predicting bacterial sexually transmitted infections (STI). Methods This prospective study was conducted in the north-west region of Romania and included patients from several medical special units such as dermatology, obstetrics-gynecology, urology, and general practice. The study group comprised patients with a high suspicion of STI, while the control group consisted of healthy subjects. Quantitative data are presented as medians (interquartile ranges). Results The median values of SII, NLR, and SIRI were higher in the group of subjects with sexually transmitted diseases compared to the control group . Regarding PLR, the median values were lower in the group of subjects with sexually transmitted diseases compared to the control group . As for LMR, the median values were equal between the two groups . Nevertheless, the differences did not reach the significance level. Conclusion Our study suggests that inflammatory biomarkers might aid in detecting bacterial STIs, but their significance was not statistically confirmed. Further research on alternative laboratory tests is needed for improved STI diagnosis and management.

https://www.semanticscholar.org/paper/8f53f2e18e9bcd715f5659b702e1866c77680398

Carbamazepine-induced hepato-splenomegaly with erythematous rashes in a child

Indian Journal of Pharmacology

98fedc17-01a6-40fe-a923-ca1c45d01c41

Carbamazepine-induced hepato-splenomegaly with erythematous rashes in a child Carbamazepine is an antiepileptic drug. In clinical trials the total incidence of reported adverse reaction to this drug is 4.5 per million at defined daily doses, corresponding to 2.7 per million at prescribed daily doses. Among the adverse reactions of carbamazepine, most often reported are skin reactions (48%), hematological (14%), hepatic disorder (10%). Herein, we present a case with erythematous skin rashes and hepato-splenomegaly.

https://www.semanticscholar.org/paper/5a3dfc347800f7ea4827c7b5cf3733cec0f9a509

Retracted: Construction Means of Soil Microbial Synusiologic Network Based on ANN

Computational Intelligence and Neuroscience

f32b7322-b69c-4e63-801d-8f50784ef778

Retracted: Construction Means of Soil Microbial Synusiologic Network Based on ANN .

https://www.semanticscholar.org/paper/95019069f3589d0f257f671684a0e7de7be8a3f7

Amyloid Beta Leads to Decreased Acetylcholine Levels and Non-Small Cell Lung Cancer Cell Survival via a Mechanism That Involves p38 Mitogen-Activated Protein Kinase and Protein Kinase C in a p53-Dependent and -Independent Manner

International Journal of Molecular Sciences

8506a01a-40b8-4e6f-bbb8-ce2492139c15

Amyloid Beta Leads to Decreased Acetylcholine Levels and Non-Small Cell Lung Cancer Cell Survival via a Mechanism That Involves p38 Mitogen-Activated Protein Kinase and Protein Kinase C in a p53-Dependent and -Independent Manner Several studies have shown an inverse correlation between the likelihood of developing a neurodegenerative disorder and cancer. We previously reported that the levels of amyloid beta (Aβ), at the center of Alzheimer’s disease pathophysiology, are regulated by acetylcholinesterase (AChE) in non-small cell lung cancer (NSCLC). Here, we examined the effect of Aβ or its fragments on the levels of ACh in A549 (p53 wild-type) and H1299 (p53-null) NSCLC cell media. ACh levels were reduced by cell treatment with Aβ 1–42, Aβ 1–40, Aβ 1–28, and Aβ 25–35. AChE and p53 activities increased upon A549 cell treatment with Aβ, while knockdown of p53 in A549 cells increased ACh levels, decreased AChE activity, and diminished the Aβ effects. Aβ increased the ratio of phospho/total p38 MAPK and decreased the activity of PKC. Inhibiting p38 MAPK reduced the activity of p53 in A549 cells and increased ACh levels in the media of both cell lines, while opposite effects were found upon inhibiting PKC. ACh decreased the activity of p53 in A549 cells, decreased p38 MAPK activity, increased PKC activity, and diminished the effect of Aβ on those activities. Moreover, the negative effect of Aβ on cell viability was diminished by cell co-treatment with ACh.

https://www.semanticscholar.org/paper/343a6f84df0c1147e26b5acffefbf25eaa01611d

Improving the Knowledge, Skills and Confidence of Clinicians Towards Mental Health: An Educational Intervention Based on Reflective Practice

BJPsych Open

7e6a8e7b-939b-4d19-af46-0878b11ff420

Improving the Knowledge, Skills and Confidence of Clinicians Towards Mental Health: An Educational Intervention Based on Reflective Practice Aims Mental illness-related stigma, including that which exists in the healthcare system creates serious barriers to access and quality care. People with lived experience of a mental illness commonly report feeling devalued, dismissed, and dehumanized by many of the health professionals with whom they come into contact. While working in the mental health liaison team in a local general hospital I have experienced first-hand these issues. We decided to organise regular reflective sessions for staff to reflect on what the barriers are to being able to manage patients with mental illness better on the wards, raise mental health awareness, improve staff communication skills, and offer teaching sessions to improve the staff knowledge of psychiatric pathology. Methods Before starting, we offered a feedback form to staff to ascertain the value of the project. To ascertain that the learning has taken place, we have delivered a post-session formative quiz to assess the staff's knowledge of managing patients with mental illness. To determine the effectiveness of the project, we decided to use Kirkpatrick's evaluation model and assess the first two levels of the programme outcome: (1) learner satisfaction- through staff feedback; (2) measures of learning- knowledge gained showed in the formative post-session quiz. Results The sessions were carried out on 2 wards in the general hospital • Ward 1: 4 sessions; number of attendees: 12 • Ward 2: 4 sessions; number of attendees: 5 The student evaluation was done through a quiz offered to the participants at the end of each session. 9 quiz questionnaires were completed on ward 1: Correct answers: Q1- 67%; Q2- 89%; Q3- 0%; Q4- 100%. 5 quiz questionnaires were completed on ward 2: Correct answers: Q1- 20%; Q2- 60%; Q3- 0%; Q4- 40%. The programme evaluation was done through a feedback form offered to the participants at the end of each session. 12 forms were completed on ward 1: 50% strongly agreed that the session was useful to their practice; 70% were quite confident in caring for patients with mental illness following the session. 5 forms were completed on ward 2: 20% strongly agreed that the session was beneficial; 75% were quite confident in caring for patients with mental illness following the session. Conclusion Difficult to implement a culture change. Following a meeting with the stakeholders, we agreed on delivering monthly reflective sessions to the staff in their allocated “team time” where attendance is mandatory and we will also take part in a developmental teaching programme for band 5 nursing staff We are in the process of extending our project to the Emergency department

https://www.semanticscholar.org/paper/4fe2fb4a608750bd00b0a7d92219a658bd05e725

Upper eyelid levator-recession and anterior lamella repositioning through the grey-line: Avoiding a skin-crease incision

Indian Journal of Ophthalmology

2bbc1e45-4074-471d-b003-2c8f5a99cdb0

Upper eyelid levator-recession and anterior lamella repositioning through the grey-line: Avoiding a skin-crease incision Purpose: This study aims to report a case series of upper eyelid cicatricial margin entropion with retraction, corrected through a grey-line approach only. We remind readers of the grey-line approach to levator recession (LR) and lamellar repositioning surgery. Methods: A retrospective review of clinic notes and photographs of patients who underwent grey-line split (GLS), LR, release of orbital septum, recession of levator, advancement of posterior lamella and anterior lamellar repositioning without a skin crease incision, from December 2015 to December 2016. Indications for surgery included mild-to-moderate cicatricial margin upper eyelid entropion, tarsal curling, and meibomian gland inversion. Patients requiring spacer interposition to lengthen the posterior lamella were excluded from the study. Parameters of the study included lid margin position, lid height, ocular surface health and symptom improvement. Results: Eleven eyelids of eight patients were included in the study, and underwent the procedure described. Lid margin position measured as the marginal reflex distance lowered (improved) in 72.7% of patients. Lid margin eversion was achieved in all eyes (100%). Corneal punctate epithelial erosions markedly improved, being present in 72.7% of patients preoperatively, and only 9.1% of patients postoperatively. Eight of eleven eyes showed symptomatic improvement, with six (54.5%) being completely asymptomatic and two achieving partial relief. An added observation was a pretarsal show asymmetry in some patients which improved in 36.4% of surgeries postoperatively. Conclusion: Upper eyelid LR with GLS and anterior lamella repositioning can all be performed through the plane of the split, avoiding a skin incision. Normal lid margin apposition was achieved in all eyes with 91% demonstrating a clear cornea and 72% having symptomatic improvement.

https://www.semanticscholar.org/paper/447db30be911ee0cf172db40ed862cff0bf5f842

Diversity of Grammars and Their Diverging Evolutionary and Processing Paths: Evidence From Functional MRI Study of Serbian

Frontiers in Psychology

89097a03-8be6-4e2d-ae2c-a6df64c77a06

Diversity of Grammars and Their Diverging Evolutionary and Processing Paths: Evidence From Functional MRI Study of Serbian We address the puzzle of “unity in diversity” in human languages by advocating the (minimal) common denominator for the diverse expressions of transitivity across human languages, consistent with the view that early in language evolution there was a modest beginning for syntax and that this beginning provided the foundation for the further elaboration of syntactic complexity. This study reports the results of a functional MRI experiment investigating differential patterns of brain activation during processing of sentences with minimal versus fuller syntactic structures. These structural layers have been postulated to represent different stages in the evolution of syntax, potentially engaging different brain networks. We focused on the Serbian “middles,” analyzed as lacking the transitivity (vP) layer, contrasted with matched transitives, containing the transitivity layer. Our main hypothesis was that transitives will produce more activation in the syntactic (Broca's–Basal Ganglia) brain network, in comparison to more rudimentary middles. The participants (n = 14) were healthy adults (Mean age = 33.36; SD = 12.23), native speakers of Serbo-Croatian. The task consisted of reading a series of sentences (middles and transitives; n = 64) presented in blocks of 8, while being engaged in a detection of repetition task. We found that the processing of transitives, compared to middles, was associated with an increase in activation in the basal ganglia bilaterally. Although we did not find an effect in Broca's area, transitives, compared to middles, evoked greater activation in the precentral gyrus (BA 6), proposed to be part of the “Broca's complex.” Our results add to the previous findings that Broca's area is not the sole center for syntactic processing, but rather is part of a larger circuit that involves subcortical structures. We discuss our results in the context of the recent findings concerning the gene-brain-language pathway involving mutations in FOXP2 that likely contributed to the enhancement of the frontal-striatal brain network, facilitating human capacity for complex syntax.

https://www.semanticscholar.org/paper/a1a8d3d2270575583ab3058e92123f4da499c293

Identification of pleiotropic and specific therapeutic targets for cardio-cerebral diseases: A large-scale proteome-wide mendelian randomization and colocalization study

PLoS ONE

0aed7a40-85f3-4c66-9e1b-c1556c57001b

Identification of pleiotropic and specific therapeutic targets for cardio-cerebral diseases: A large-scale proteome-wide mendelian randomization and colocalization study Background The cardiac-brain connection has been identified as the basis for multiple cardio-cerebral diseases. However, effective therapeutic targets for these diseases are still limited. Therefore, this study aimed to identify pleiotropic and specific therapeutic targets for cardio-cerebral diseases using Mendelian randomization (MR) and colocalization analyses. Methods This study included two large protein quantitative trait loci studies with over 4,000 plasma proteins were included in the discovery and replication cohorts, respectively. We initially used MR to estimate the associations between protein and 20 cardio-cerebral diseases. Subsequently, Colocalization analysis was employed to enhance the credibility of the results. Protein target prioritization was based solely on including highly robust significant results from both the discovery and replication phases. Lastly, the Drug-Gene Interaction Database was utilized to investigate protein-gene-drug interactions further. Results A total of 46 target proteins for cardio-cerebral diseases were identified as robust in the discovery and replication phases by MR, comprising 7 pleiotropic therapeutic proteins and 39 specific target proteins. Followed by colocalization analysis and prioritization of evidence grades for target protein, 6 of these protein-disease pairs have achieved the highly recommended level. For instance, the PILRA protein presents a pleiotropic effect on sick sinus syndrome and Alzheimer’s disease, whereas GRN exerts specific effects on the latter. APOL3, LRP4, and F11, on the other hand, have specific effects on cardiomyopathy and ischemic stroke, respectively. Conclusions This study successfully identified important therapeutic targets for cardio-cerebral diseases, which benefits the development of preventive or therapeutic drugs.

https://www.semanticscholar.org/paper/fba59e36843e5d3c9d968825c789b15d5d338388

Hepcidin Expression in Psoriasis Patients

Indian Journal of Dermatology

9dfbd503-d104-4952-88dc-462e8ce2e5c2

Hepcidin Expression in Psoriasis Patients Background: Iron is an essential nutrient for mammals. Accelerated loss of nutrients through hyperproliferation and desquamation from the skin in psoriasis is known. Hepcidin is an important and recently discovered regulator of iron homeostasis. Aims and Objectives: The present study was undertaken to investigate the hepcidin expression in psoriasis patients. Materials and Methods: We examined peripheral blood cell counts, serum Fe, ferritin, interleukin-6 (IL-6) and hepcidin levels using respectively automated hematology analyzer, Iron assay on the AEROSET system, chemiluminescent microparticle immunoassay with automated analyzer, and enzyme-linked immunosorbent assay. Results: The independent comparison of Fe, ferritin, IL-6 and hepcidin levels in psoriasis patients and control group (healthy volunteers) revealed lower Fe and higher IL-6, hepcidin levels in psoriasis patients. No significant difference was seen in the ferritin level between the psoriasis and the control group. Conclusions: We think that studies on hepcidin expression in psoriatic plaques will contribute to our understanding the role of iron and hepcidin in the pathogenesis of psoriasis.

https://www.semanticscholar.org/paper/738f5c7accbaf135a16f0293f28c49ec2738b4a7

The Chelsea Hospital for Women

The Hospital

965d752e-3d99-47a6-bf0f-de96ba26b1f3

The Chelsea Hospital for Women The report just presented to Earl Cadogan, President of the Chelsea Hospital for Women, by the Special Committee appointed to inquire into the mortality which has attended the proceedings of that institution, is a document requiring the most anxious consideration from all who are concerned in hospital management, or who desire that the work of a hospital should combine the maximum of good with the minimum of evil. We publish a full abstract of this report in another column. It is hardly necessary to say that aggregation of the sick is not in itself

https://www.semanticscholar.org/paper/b5153e9cacc3ce71efec24067890f42412a41b14

Challenges in Conducting Studies in Chronic Graft-versus-Host Disease

Clinical Hematology International

d9f6814c-8657-403f-aa93-1489345f15cb

Challenges in Conducting Studies in Chronic Graft-versus-Host Disease The lack of standardized criteria for measuring therapeutic response has been a major obstacle to the development of therapeutic trials in chronic graft-versus-host disease (cGvHD). Nevertheless, recent advances have been made in understanding of the biology and pathophysiology of cGvHD, as well as establishing more precise criteria for the diagnosis and classification of disease manifestations. The momentum has shifted, and currently there is a long list of new potential treatment targets being identified for cGvHD. Consequently, new drugs are being implemented for its prophylaxis and treatment. It is crucial to continue that trend and develop better systems to test new drugs in clinical practice that would eventually translate toward seeking regulatory review and approval. We provide a historical perspective and current challenges in conducting cGvHD clinical trials.

https://www.semanticscholar.org/paper/6f1e8c0c128f41dc22985cd6a911e8a1c75c63e8

Primary myelofibrosis evolving to an aplastic appearing marrow

Clinical Case Reports

2fc41bcb-65e9-40df-b1c3-df9c09e1bede

Primary myelofibrosis evolving to an aplastic appearing marrow Our case highlights a series of bone marrow biopsies from a patient with primary myelofibrosis. Over time, this patient developed an unusual fatty appearance to his marrow, confirmed on multiple biopsies. This finding was supported by a quantitative fat MRI sequence that also shows a fatty appearance to the marrow.