Datasets:

RJuro

/

neuro_patents

like 2

2016-02-29

N

Apparatus for calculating term co-occurrence scores for use in a natural language processing method, where a term is a word or a group of consecutive words, in which apparatus at least one text document is analysed and pairs of terms, from terms which occur in the document, are ascribed respective co-occurrence scores to indicate an extent of an association between them, comprises sentence sequence processing means (280) and co-occurrence score set calculation means (230), wherein: the sentence sequence processing means (280) are operable to: for each of all possible sequences of sentences in a document, where the minimum number of sentences in a sequence is one and the maximum number of sentences in a sequence has a predetermined value, determine a weighting value w which is a decreasing function of the number of sentences in the sentence sequence; determine a sentence sequence count value, based on the sum of all the determined weighting values; obtain a document term count value, where the document term count value is the sum of sentence sequence term count values determined for all the sentence sequences, each sentence sequence term count value indicating the frequency with which a term occurs in a sentence sequence and being based on the weighting value for the sentence sequence; and for each of all possible different term pairs in all sentence sequences, where a term pair consists of a term in a sentence sequence paired with another term in the sentence sequence, obtain a term pair count value which is the sum of the weighting values for all sentence sequences in which the term pair occurs; and the co-occurrence score set calculation means (230) are operable to obtain a term co-occurrence score for each term pair using the document term count values for the terms in the pair, the term pair count value for the term pair and the sentence sequence count value. Apparatus for processing sentence pairs is also disclosed.

en

PROBABILISTIC MODEL FOR TERM CO-OCCURRENCE SCORES

49616178_JP

53412440_IE,53418419_IE

G06F 16/3344,G06F 16/3346,G06F 16/93,G06F 40/216,G06F 40/284,G06N 7/005

1997-12-08

N

Human 11cb splice variant polypeptides and DNA (RNA) encoding such an 11cb splice variant and a procedure for producing such polypeptides by recombinant te chniques are disclosed. Also disclosed are methods for utilizing such an 11cb splice vari ant for the treatment of infections, such as bacterial, fungal, protozoan and viral infectio ns, particularly infection caused by HIV-l or HIV-2; pain; cancers; anorexia; bulimia; asthma; Pa rkinson's disease; both acute and congestive heart failure; hypotension; hypertension; uri nary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizop hrenia, manic depression, delirium, dimentia or severe mental retardation; dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others. Antagonist s against such an 11cb splice variant and their use as a therapeutic to treat infections, such as bacterial, fungal, protozoan and viral infections, particularly infaction caused by HIV-1 o r HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; both acute and co ngestive heart failure; hypotension; hypertension; urinary retention; osteoporosis; angin a pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy and psych otic and neurological disorders, including anxiety, schizophrenia, manic depression, deli rium, dementia or severe mental retardation; and dyskinesias, such as Huntington's dis ease or Gilles dela Tourett's syndrome, among others, are also disclosed. Also disclosed are di agnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for det ecting mutations in the polynucleotides encoding the 11cb splice variant and for detect ing altered levels of the polypeptide in a host.

en

NOVEL HUMAN 11 CB SPLICE VARIANT

5494191_US

16551903_US,16546402_US

A61K 38/00,A61P 3/04,A61P 3/08,A61P 9/00,A61P 9/02,A61P 9/12,A61P 11/00,A61P 13/02,A61P 15/00,A61P 25/00,A61P 25/18,A61P 29/00,A61P 31/04,A61P 31/12,A61P 35/00,C07K 14/721,C07K 14/723

1991-04-22

N

A digital echo canceller has a receive path (2) and a send path (3) and comprises combining means (10) for forming a send output signal [r(k)] as the difference between the signal [z(k)] applied to the send input (SI) and a replica signal [ê(t)] used for cancelling an additive echo signal [e(k)] at the send input (SI) that has developed in response to a receive input signal [x(k)] applied to the receive input (RI), which echo canceller at least includes transforming means (13,15) for transforming the receive input signal [x(k)] and the send output signal [r(k)]; transforming means (14) for transforming the replica signal [ê(k)]; a digital adaptive filter (9) which has a number of filter coefficients for generating the replica signal [ê(t)] in response to the receive input signal [x(k)] and the send output signal [r(k)], adaptation means (12) for determining for each block m, adaptation components [A(p;m)] for each of the filter coefficients [W(p;m)] in response to the receive input signal [x(k)] and the send output signal [r(k)]; controllable gate means (17) for selectively passing the adaptation components [A(p;m)] to the adaptive digital filter (9); control means (25-18, 21-24, 16) for determining respective levels of the send output signal [r(k)] and the receive input signal [x(k)] and for generating a control signal for the gate means (17) in response to the levels thus determined, which control signals depend in a predetermined manner on the difference between the levels concerned. The control means (21-28, 16) and gate means (17) operate in the frequency-domain if the transforming means (13, 15, 14) perform an N'-point DOT or N'-point IDOT of each block m of N' points and determine for each of the N' frequency-domain points a separate control signal in dependence on the respective levels of the receive input signal [x(k)] and the send output signal [r(k)] for the frequency-domain point concerned. <IMAGE>

en

Digital echo canceller comprising a double-talk detector.

1501_NL

3028004_NL,3028003_NL,3028005_NL

H04B 3/234

2020-01-14

N

Methods are provided for treating conditions including chronic pelvic pain, in which there are palpable trigger points of local areas of muscle restriction and spasticity that recreate or refer pain of patients complaints upon palpation, chronic pelvic pain syndrome, pelvic floor myalgia, pelvic floor dysfunction, interstitial cystitis, levator ani syndrome, coccygodynia, prostatodynia, piriformis syndrome, anal sphincter pain, bowel movement pain, post bowel movement pain, ejaculatory pain, post ejaculatory pain, sitting pain, post bowel movement pain, rectal pain, tailbone pain, urinary frequency, urinary urgency, urinary hesitancy, post urinary pain, overactive bladder, perineal pain, penile pain, vaginismus, anismus, sexual dysfunction, reduced level of ejaculate or reduced penile erection, myofascial pain in muscle tissue of a patient who has one or more trigger points in the muscle tissue, or the pain/sensitivity of pelvic floor muscle trigger points and specific areas of myofascial restriction detected upon palpation in a patient comprising administering to the one or more trigger points of the patient in need thereof a therapeutically effective amount of a calcium channel blocker, or L-arginine, or a combination of a calcium channel blocker and L-arginine, or pharmaceutically acceptable salts, hydrates, solvates and prodrugs thereof; the application of the topical form of the drug can be applied by the patient regularly as part of a self treatment program to heal muscle related pain and muscle related pelvic pain and each optionally together with a corticosteroid such as cortisone of hydrocortisone. The invention further provides methods for myofascial release, trigger point release, and the use of dilators with and without calcium channel blockers for pain conditions. The invention further provides pharmaceutical compositions, kits and applicator devices useful in the methods of the invention.

en

METHODS FOR TREATING CARPAL TUNNEL PAIN

50011014_US

50011014_US

A61K 9/0031,A61K 9/02,A61K 9/06,A61K 31/167,A61K 31/198,A61K 31/4422,A61K 31/554,A61K 31/573,A61K 45/06,A61K 47/10,A61K 47/14,A61K 47/44,A61M 29/00

2018-10-22

Y

Distributed acoustic sensing system (100), for coupling with an optical sensing fiber (110), which has a selectable fiber length and a down-and-up travel time for an interrogating light to travel down the fiber length and for backscattered light to travel up the fiber length, the down-and-up travel time being associated to the fiber length. The distributed acoustic sensing system (100) has: a coherent light source device (101) configured to repeatedly generate and send into an optical sensing fiber (110) a coherent interrogating light pattern (307, 507, 607, 707), which is out of a plurality of coherent interrogating light patterns and composed of coherent carrier light, during a measurement time duration, which is equal to or greater than one times the down-and-up travel time of the optical sensing fiber (110). The device (100) further has a detection device (114, 116) configured to detect over time light that is backscattered in the optical sensing fiber (110) in response to the repeatedly sent coherent interrogating light patterns and to generate and output a signal that is indicative of the detected backscattered light. The system (100) further has an evaluation device (118) configured to analyse the signal output from the detection device (114, 116). Each coherent interrogating light pattern (307, 507, 607, 707) out of the plurality of coherent interrogating light patterns has similar physical properties, wherein the similarity is in the sense that the light patterns cannot be distinguished on the basis of comparing the physical properties of the backscattered light generated from at least two successive interrogating light patterns (507, 607, 707) as such as detected. The coherent light source device (101) is capable to change the time period between successively sent the first coherent interrogating light patterns (507, 607, 707) after the passing of at least one measurement time duration.

en

DISTRIBUTED ACOUSTIC SENSING DEVICE USING DIFFERENT COHERENT INTERROGATING LIGHT PATTERNS, AND CORRESPONDING SENSING METHOD

52328939_DE

69756617_DE

E21B 47/135,G01D 5/35361,G01H 9/004

2007-09-03

N

This invention relates to compounds and methods for the treatment of a co ndition mediated by CB1 receptor activity in a mammalian subject including a human, which comprises administering to a mammal in need of such treatment a therapeutically effective amount of the compound of formula (I) or pharmac eutically acceptable salts thereof, wherein: A, B, R1, R2 and R3 are each as described herein. These compounds are useful in the treatment of a conditio n mediated by CB2 receptor binding activity such as, but not limited to, inf lammatory pain, nociceptive pain, neuropathic pain, fibromyalgia, chronic lo w back pain, visceral pain, acute cerebral ischemia, pain, chronic pain, acu te pain, post herpetic neuralgia, neuropathies, neuralgia, diabetic neuropat hy, HIV-related neuropathy, nerve injury, rheumatoid arthritic pain, osteoar thritic pain, back pain, cancer pain, dental pain, fibromyalgia, neuritis, s ciatica, inflammation, neurodegenerative disease, spasticity, epilepsy, Tour ette's syndrome, Parkinson's disease, neuroprotection, anxiety, cough, bronc ho constriction, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colitis, cerebrovascular ischemia, cachexia, nausea, emesis, chemothe rapy-induced emesis, rheumatoid arthritis, asthma, Crohn's disease, ulcerati ve colitis, asthma, dermatitis, seasonal allergic rhinitis, gastroesophageal reflux disease (GERD), constipation, diarrhea, functional gastrointestinal disorder, cutaneous T cell lymphoma, multiple sclerosis, osteoarthritis, pso riasis, systemic lupus erythematosus, diabetes, glaucoma, osteoporosis, glom erulonephritis, renal ischemia, nephritis, hepatitis, cerebral stroke, vasod ialation, hypertension, vasculitis, myocardial infarction, cerebral ischemia , reversible airway obstruction, adult respiratory disease syndrome, chronic obstructive pulmonary disease (COPD), cryptogenic fibrosing alveolitis and bronchitis.

en

BENZIMIDAZOLONE DERIVATIVES

12487515_US

13064939_JP,13352771_JP,40416603_US,13365488_US,16136547_JP,13410708_JP

A61K 31/16,A61P 1/00,A61P 1/02,A61P 1/04,A61P 1/10,A61P 1/12,A61P 1/16,A61P 3/10,A61P 7/00,A61P 9/08,A61P 9/10,A61P 9/12,A61P 11/00,A61P 11/02,A61P 11/06,A61P 11/08,A61P 11/14,A61P 13/12,A61P 17/06,A61P 19/00,A61P 19/02,A61P 19/10,A61P 25/00,A61P 25/02,A61P 25/04,A61P 25/08,A61P 25/16,A61P 25/22,A61P 25/28,A61P 27/06,A61P 29/00,A61P 31/18,A61P 35/00,A61P 37/02,A61P 37/08,A61P 43/00,C07D 235/26,C07D 401/06,C07D 403/06,C07D 403/12,C07D 405/06,C07D 413/06,C07D 413/12,C07D 413/14,C07D 471/04

1995-11-28

N

An intrusion-alarmed optical fiber communication system, where light from two or more sources are launched with a planar channel waveguide launcher into two or more modes of a multimode graded-index transmission fiber, is disclosed. Input fibers containing the source light waves and the output fibers are in direct contact with the waveguide channels. Waveguide channels redistribute the light from input channels to output channels by rerouting, crossing, merging, and splitting channels. Waveguide launcher precisely launches data light into the fundamental mode and intrusion monitor light into high order modes of a multimode graded-index fiber. Fiber intrusion attenuates light in high order modes, but much less of the data in the fundamental mode, thereby forming a basis for the intrusion-alarmed system. Waveguide launcher permits light from a plurality of sources to be launched selectively into several types of fibers: singlemode fibers, multimode fibers, multicore fibers, multimode fibers having high refractive-index ring profile within the fiber core boundary. Waveguide channel configuration permits other versatile functions to be performed: these include optical time domain reflectometry, channel feedback stabilization of the diodes, launching light from more than one light source into the fundamental mode of a multimode graded-index fiber, and other functions. Means for launching and propagating the fundamental mode in multimode graded-index fiber in order to increase bandwidth capacity of said fiber are disclosed. Optical-electronic intrusion-alarmed systems with synchronous phase sensitive detection of intrusion are described, including reference recovery means. In order to decrease false alarm rates, information on transmitter light source variations are transmitted to the receiver via digital bit stream. A precise fiber optic sensor system based on the waveguide launcher is disclosed.

en

MULTIPLE MODAL OPTICAL FIBER INTRUSION-ALARMED COMMULTIPLE MODAL OPTICAL FIBER INTRUSION-ALARMED COMMUNICATION AND SENSOR SYSTEMS MUNICATION AND SENSOR SYSTEMS

37730328_US,37730331_US,37730330_US,37730329_US

37730328_US,37730330_US,37730331_US,37730329_US

G02B 6/12007,G02B 6/125,G02B 6/14,G02B 6/30,H04B 10/2581

1980-07-08

Y

The problem is that available automatic objective visual acuity measuring devices are not practical for mass vision testing since they are complex in nature, having considerable electronics and lens systems, and, therefore, expensive. The present invention by eliminating complex lens systems, complicated mechanics and extensive electronics is simple to operate and inexpensive. A visual acuity device measures the visual acuity of a patient's eye (12) by directing a pulsating beam of light (10) on the eye and detecting the resulting reflection. A primary pattern (22) having a pattern formed by transparent and non-transparent portions is positioned in the optical path of the pulsating beam of light. A fixed pair of analyzer or secondary patterns (34 and 36) is positioned in the optical path of the beam of light reflected from the patient's eye. One (34) of these analyzer or secondary patterns has a pattern which substantially corresponds to the pattern of the primary fixation pattern and the other (36) has a pattern which is negative mirror image of the pattern of the first analyzer or secondary pattern. The beam of light reflected from the patient's eye is divided by a beam splitter (32) so that each of the analyzer patterns receives the reflected image of the primary pattern from the patient's eye. A photoelectric device (42 and 44) is associated with each of the analyzer patterns for detecting the reflected beam of light passing through each of these analyzer patterns to generate an electrical output signal. The photoelectric devices are connected to a difference amplifier (58) for eliminating any glare and generating a signal which is determinative of the visual acuity of the patient's eye. Far visual acuity can be measured by using infrared light adding a collimating (52) and compensating (54) lens. Thus, the visual acuity device objectively measures both far and near visual acuity.

en

PULSE PATTERN VISUAL ACUITY DEVICE

37459048_

37459049_US

A61B 3/12

2020-04-10

N

A method, a computer implemented method, and a device, all for adaptively testing a subject's neurological state. The method comprising the steps of: administering one or more seed questions; obtaining one or more answer(s) to the one or more seed questions; calculating a score value of a latent subject trait from the answers to the one or more seed questions; the method comprising an adaptive test loop, comprising: (a) selecting, based on the score value, one or more further questions from a bank of questions; (b) administering the one or more further questions to the subject; (c) updating the score value based on the answers to the one or more further questions; (d) determining whether a test completion criteria has been met; wherein the method repeats steps (a) - (d) in sequence until the test completion criteria has been met, and provides an output of the test based on the score value which is indicative of the subject's neurological state. A method, a computer implemented method, and a device, all for adaptively testing a subject's neurological state. The method comprising the steps of: administering one or more seed questions; obtaining one or more answer(s) to the one or more seed questions; calculating a score value of a latent subject trait from the answers to the one or more seed questions; the method comprising an adaptive test loop, comprising: (a) selecting, based on the score value, one or more further questions from a bank of questions; (b) administering the one or more further questions to the subject; (c) updating the score value based on the answers to the one or more further questions; (d) determining whether a test completion criteria has been met; wherein the method repeats steps (a) - (d) in sequence until the test completion criteria has been met, and provides an output of the test based on the score value which is indicative of the subject's neurological state.

en

Adaptive neurological testing method

55455133_MY

12533509_GB,12533514_GB,77023968_GB,56448060_DE,74165578_GB

A61B 5/165,A61B 5/4088,A61B 5/7275,A61B 5/742,A61B 5/7475,G16H 10/20,G16H 20/70,G16H 50/30

2018-12-27

N

The present invention relates to a device and a method for inducing the promotion of cerebral blood circulation by using PINS to stimulate nerve endings distributed in the epidermal layer or the dermal layer below the skin surface of a carotid artery counterpart or a vertebral artery counterpart of the neck, thereby relaxing blood vessels of the brain. The device for inducing the promotion of cerebral blood circulation, according to the present invention, comprises: a beam emitter including a light source and emitting, according to a beam emission control signal, light at a carotid artery counterpart or a vertebral artery counterpart, which is at the skin surface of the neck in an area including a carotid artery and a vertebral artery for supplying blood and oxygen to the brain; and a beam emission control device for generating the beam emission control signal and transmitting the same to the beam emitter according to setting data including a beam emission time. The beam emitter stimulates the nerve endings distributed in the epidermal layer or the dermal layer below the skin surface of the carotid artery counterpart or the vertebral artery counterpart by emitting light for a preset beam emission time, so as to induce the secretion of a nitric oxide-containing material in nitrergic nerve terminals connected to the stimulated nerve endings and the nervous system, and to allow the secreted material to relax the blood vessels and lymph vessels coming in contact with the nitrergic nerve terminals such that the promotion of cerebral blood circulation and the promotion of lymphatic circulation are induced, and thus oxygen and nutrition are promoted in damaged cells, such as astrocytes, that are responsible for the function of the brain clearance system, thereby slowly restoring the function of the damaged brain clearance system, such that accumulation of amyloid beta plaque is inhibited.

en

DEVICE AND METHOD FOR INDUCING PROMOTION OF CEREBRAL BLOOD CIRCULATION

71132333_KR

64245669_KR,67565015_KR

A61N 5/06,A61N 5/0622,A61N2005/0626,A61N2005/0643,A61N2005/0651,A61N2005/0662

1982-11-16

Y

1. A hydrostatic-mechanical transmission with input split power, comprising two three-shaft planetary gear sets I and II, in which one difference shaft (annulus 2') of the planetary gear set I forms a unit, and, together with the sum shaft (cage s') of the planetary gear set II, forms the drive shaft, in which the second difference shaft (sun wheel 1') of the planetary gear set I is coupled with one difference shaft (sun wheel 1') of the planetary gear set II and is connected via a hydrostatic transmission (b) with the drive shaft (1), and in which the sum shaft (cage s) of the planetary gear set I on the one hand and the second difference shaft (annulus 2') of the planetary gear set II on the other hand can act alternately, by way of output coupling stages, upon the driven shaft (2), so that several unstepped gearchange ranges in series (1 to 4 and R) form the total gearchange ratio range, with the output coupling stages exhibiting at any given instant the same transmission ratio for two adjacent gearchange ranges, beginning with gearchange range 1 which follows the starting range, with the output coupling stages for the odd-number gearchange ranges (1 and 3) being coupled to the sum shaft (cage s) of the planetary gear set I and the output coupling stages for the even-number gearchange ranges (2 and 4) being coupled to the difference shaft (annulus 2') of the planetary gear set II, and with the output coupling stages being adjusted in their ratios in such a way that changes of gearchange range take place synchronously without load and without interruption of tractive power, characterised by the combination of the following features, known in themselves : a. that for starting a friction clutch (K) is provided between the motor and the drive shaft b. that the output coupling stages consist of spurgear stages c. that the output coupling stages are connected to jaw clutch couplings.

en

HYDROSTATIC-MECHANICAL TRANSMISSION WITH INPUT SPLIT POWER

2333405_DE

2333407_DE,2333408_DE,2333406_DE

F16H 47/04,F16H2037/0886

2021-03-27

Y

A remote sensing image classification method for multi-task iterative learning and memorizing is provided and includes: initializing previous parameters, a fixed weight, and a temporary weight, performing a prediction performance; calculating a sensitivity of each parameter; training the model by using a modified loss function to thereby learn the previous parameters, when the model learns a new task; developing a new neuron to learn a new class in the new task, re-initializing the temporary weight to learn the temporary weight, performing the prediction performance; calculating the sensitivity matrix of parameters added in a loss function for a training of a next task by using the sensitivity matrix of the parameters by using training data of the new task; repeating the above steps when the new task is coming for training; performing a remote sensing image classification by using the classifier of the model as trained. start initializing previous parameters of a classifier of a model, a fixed weight of the classifier, and a temporary weight of the classifier, obtaining the and the by training, assigning the to the , and performing a prediction performance by using the and the calculating sensitivity matrix of parameters modifying an original loss function and adding a regularization term, when the model learns a new task, and learning the previous parameters of the classifier developing a new neuron, re-initializing the temporary weight of the classifier, training the model to obtain the , assigning the to the , and performing the prediction performance by using the and the calculating the sensitivity matrix of the parameters of a current task by the model; accumulating and averaging the sensitivity matrix of the parameters of the current task and the sensitivity matrix as previously calculated to obtain the sensitivity matrixes of the parameters as new a new task is coming end

en

REMOTE SENSING IMAGE CLASSIFICATION METHOD FOR MULTI-TASK ITERATIVE LEARNING AND MEMORIZING

18138654_CN

53097368_,14737137_,80315972_,37839718_,79893537_

G06K 9/6256,G06K 9/6267,G06V 20/13

2008-02-19

N

Disclosed are 4-alkyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indol]-4-amine derivatives as represented by the general formula (I), wherein R1 and R2 independently of one another represent H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, or the radicals R1 and R2 together form a morpholine or piperazine ring system; R3 represents alkyl which may be saturated or unsaturated, branched or unbranched, unsubstituted or substituted by one or more F, Cl, Br, I, CN, NH2, NO2, SH, cyclopentyl, cyclohexyl, CF3, OH, OCH3, OC2H5 or dimethylamino; X represents O, S, SO, SO2 or NR17; and wherein the remaining substituents are as defined herein. Further disclosed is a medicament which comprises at least one spirocyclic cyclohexane derivative as defined above and optionally comprising one or more suitable additives and/or auxiliary substances and/or additional active ingredients for the treatment of one or more of anxiety, stress, depression, epilepsy, Alzheimer's disease, senile dementia, general cognitive dysfunctions, learning and memory disorders, withdrawal symptoms, alcohol and/or drug and/or medicament abuse and/or dependency, sexual dysfunctions, cardiovascular diseases, hypotension, hypertension, tinnitus, pruritus, migraine, impaired hearing, deficient intestinal motility, impaired food intake, anorexia, obesity, locomotor disorders, diarrhoea, cachexia, urinary incontinence or as a muscle relaxant, anticonvulsive or anaesthetic or for co-administration in the case of treatment with an opioid analgesic or with an anaesthetic, for diuresis or antinatriuresis, anxiolysis, for modulation of motor activity, for modulation of neurotransmitter secretion and treatment of one or more neurodegenerative diseases associated therewith, for the treatment of withdrawal symptoms and/or for reducing the addictive potential of one or more opioids.

en

SPIROCYCLIC CYCLOHEXANE DERIVATIVES

12680714_

15016541_,33998848_,15044093_,15081771_,40515868_

A61K 31/407,A61P 1/00,A61P 1/06,A61P 1/10,A61P 3/04,A61P 7/00,A61P 9/00,A61P 9/12,A61P 13/02,A61P 13/10,A61P 15/10,A61P 17/04,A61P 21/00,A61P 21/02,A61P 23/00,A61P 25/00,A61P 25/04,A61P 25/06,A61P 25/08,A61P 25/18,A61P 25/22,A61P 25/24,A61P 25/28,A61P 25/30,A61P 25/32,A61P 25/36,A61P 27/16,A61P 29/00,A61P 43/00,C07D 471/10,C07D 491/107,C07D 495/10

2000-03-16

Y

An in-focus image of an information-bearing region within and/or on a substance is discriminated from an out-of-focus image so as to reduce errors in image information of the substance by producing a probe beam and a reference beam from a wideband point source, producing antisymmetric spatial properties in the reference beam, converting the probe beam to a beam focused to a line in the region, producing an in-focus return probe beam, and producing antisymmetric spatial properties in the in-focus return probe beam. Then the in-focus return probe beam is spatially filtered and focused to a line image in a detector plane of a detector system. The reference beam is spatially filtered and focus to a line image in the detector plane. A beam from an out-of focus image point is spatially filtered. The line image of the spatially filtered reference beam is interfered with the spatially filtered beam from the out-of-focus image point and the line image of the spatially filtered in-focus return probe beam. A complex amplitude of the spatially filtered in-focus return probe beam is detected as an interference term between line image of the spatially filtered reference beam and the line image of the spatially filtered in-focus return probe beam by means of the detector system. An amplitude of an interference term between the spatially filtered out-of-focus image beam and the line image of the spatially filtered reference beam is thereby substantially reduced, and reduces statistical and systematic errors in data produced by the detector system to represent the image information of the region. The image information is acquired as either one-dimensional or two-dimensional data arrays wherein the elements of the arrays are obtained substantially simultaneously. The substance is scanned to generate images of dimensionalities greater than the one-dimensional or two-dimensional data arrays.

en

Multiple layer confocal interference microscopy using wavenumber domain reflectometry and background amplitude reduction and compensation

5529709_US

5529710_US

G01B 9/02027,G01B 9/02042,G01B 9/04,G02B 21/004,G02B 21/0056,G02B 21/006,G02B 21/0068,G02B 21/008,G11B 7/005,G11B 7/14

2018-11-23

Y

Text segmentation has a long history going back to few of the earliest attempts. However, segmenting informal text has resulted in information loss with less 5 accuracy. Embodiments of the present disclosure provide systems and methods for segmenting interactive session text that includes a plurality of input text posts using the information bottleneck method, augmented with sequential continuity constraints. Furthermore, the present disclosure and its embodiments utilize critical non-textual clues such as time between two consecutive posts and people mentions 10 within the posts to reduce information loss. Using the fusion of all textual and non textual information from the input text posts in the proposed information bottleneck approach for text segmentation allows to exploit non-textual information collectively with the text involved in the conversations to achieve better segmentation. I ULI INU. U1 011VVL5. I4 Obtaining a plurality of input text posts pertaining to a 202 plurality of users Computing a distance value for one or more criteria comprising (i) a first criteria that is indicative of a plurality of pairs of adjacent input text posts from the plurality of input text posts, (ii) a second criteria that is indicative of a time - 204 difference between at least two consecutive input text posts, and (iii) a third criteria that is indicative of one or more users from the plurality of users Assigning a weightage to each distance value computed for the one or more criteria 206 Computing a weighted sum based on the assigned 208 weightage Generating based on the one or more criteria, using a corresponding distance value obtained from the weighted sum, a segmented interactive session text from the plurality of input text posts Updating the distance value associated with each of the two or more adjacent input text posts, the time difference and the 212 one or more users

en

SYSTEMS AND METHODS FOR SEGMENTING INTERACTIVE SESSION TEXT

6182385_IN

71412468_,53922387_,48992766_,53816745_

G06F 16/355,G06F 16/358,G06F 40/103,G06F 40/131,G06F 40/20,G06F 40/289,G06F 40/30,G06N 3/0445,G06N 3/0454,G06N 7/005

2007-05-22

N

Principles from the analogous field of cardiac electrophysiology are translated to neuro electrophysiology whereby electrically competent catheters and introducing devices are threaded intravascularly through large vessel access (e.g., leg or arm) into the arterial or more typically the venous system to or within the brain tissue, possibly targeting a specific region that needs to be functionally mapped. After passive recording and mapping of important activity exactly to a 3-dimensional, high resolution brain image taken either before or during the procedure, electrical stimulation paradigms are triggered to both evoke responses to help map regions vital to the epileptic network or pathologically functioning networks in other neurological and/or psychiatric conditions, and then to map brain function in specific regions during motor, sensory, emotional, psychiatric and cognitive testing, in order to localize these functions in relation to the epileptic network. Once this pathological and functional map has been created, clinicians can then either proceed to: (1) subdural and intraparenchymal electrode placement, for chronic ictal recording, based upon the maps, (2) use of the catheter-based system to ablate regions vital to generating seizures, using either electrical stimulation or another therapy, (3) placement or chronic electrodes, effector devices, drugs, sensors, etc. to be used as part of an implantable diagnostic/therapeutic device, and/or (4) more chronic diagnostic recording by leaving behind other sensors. Principles for chronic monitoring and activating implantable devices are implemented using acutely or chronically placed sensors on, within or around tissues electrically coupled to and not in contact with the brain to work in concert with devices focused on diagnosis and/or treatment of syncope, epilepsy, and other neurological and psychiatric disorders.

en

METHOD AND DEVICE FOR THE RECORDING, LOCALIZATION AND STIMULATION-BASED MAPPING OF EPILEPTIC SEIZURES AND BRAIN FUNCTION UTILIZING THE INTRACRANIAL AND EXTRACRANIAL CEREBRAL VASCULATURE AND/OR CENTRAL AND/OR PERIPHERAL NERVOUS SYSTEM

9810433_US,5223267_US

8493866_US,9810434_US

A61B 5/291,A61B 5/377,A61B 5/4094,A61B 90/37,A61B2034/2051,A61N 1/056,A61N 1/36017,A61N 1/36053,A61N 1/36064,A61N 1/36135

2013-02-27

Y

PURPOSE: An emotional control system of audio and lighting, using a mobile device and a method thereof are provided to transfer sound source files which an individual possesses to an audio system through wireless telecommunications, play the files in the audio system, and download sound sources in the audio system to a mobile device. CONSTITUTION: Wireless communications units (11,21,51) are equipped to send audio data to a mobile device or to receive audio control data from a mobile device. Control units (12,54) analyze the transmitted audio control data to sound source data, and generate a control signal controlling an audio and lighting emotional control system. Sound source storages (13,55) store and extract sound source data according to the control signal of the audio control unit. A sound source playing unit (14) plays the sound source data. Characteristic detecting units (15,5) extract the characteristics of sound tones, rhythm and intensity based on the played sound source when a sound source emotion evaluation is set. Emotion evaluation units (16,58) judge the emotional index of emotional data preset in the sound source based on the extracted characteristic. Lamp color converters (17,59) generate a lamp color control signal matching by the emotional index. A transmission signal converter transmits a lamp converting control signal to a lighting device. [Reference numerals] (10) Audio/lamp control device; (11,21) Wireless communications unit; (12) Control unit; (13,24) Sound source storage unit; (14) Sound source playing unit; (15) Characteristic of sound source extracting unit; (16) Emotion of sound source evaluation unit; (17) Multi-emotional index lamp color converter unit; (18) Limp control signal converter unit; (20) Mobile device; (22) User input unit; (23) Screen display unit; (25) Ambiance control unit; (30) Speaker device; (40) Full COLOR lamp device

en

SYSTEM AND METHOD FOR AUDIO AND LIGHTING EMOTIONAL CONTROL USING MOBILE DEVICE

12571541_KR

33016893_KR,41456801_KR,12643678_KR

G10L 25/48,H05B 47/19

1986-04-01

Y

A combination of a transmitter and implantable receiver are disclosed wherein data is conveyed from transmitter to receiver utilizing a data format in which each channel to be stimulated is adapted to convey information in monopolar, bipolar or analog form. The data format includes two types of code words: transition words in which one bit is assigned to each channel and can be used to create monopolar pulsatile or bipolar pulsatile waveforms; and amplitude words that can create analog waveforms one channel at a time. An essential element of the output system is a current source digital to analog converter which responds to the code words to form the appropriate output on each channel. Each output is composed of a set of eight current sources, four with one polarity of current and the other four with the opposite polarity of current. In each group of four, the current sources are binarily related, I, 2I, 4I and 8I. In this arrangement each channel can supply 16 amplitudes times two polarities of current; meaning 32 current levels. This channel is simply a 5-bit digit to analog converter. The output circuitry contains charge balance switches. These switches are designed to recover residual charge when the current sources are off. They are also designed to current limit during charge recovery if the excess charge is too great so that they do not cause neural damage. Each channel charge balances (will not pass DC current or charge) and charge limits to prevent electrode damage and bone growth. The charge balancing is performed by the charge balancing switches and by the blocking capacitor. The charge limiting is performed by the blocking capacitor only. The charge level on each channel is defined using a switch network ladder which combines a plurality of parallel connected switches; closure of each switch doubles the current level handed off from the previous switch.

en

MULTI-CHANNEL IMPLANTABLE NEURAL STIMULATOR

16128628_US

13383208_US

A61N 1/36038

2014-05-27

N

The present invention provides a method for determining the binding ability of a G-protein coupled receptor, hereinafter referred to as GPCR, and a mutateable ligand, said method comprising the steps of: a) providing a well microtiter plate having the wells disposed in a array having a first number of rows and a second number of columns; b) providing a GPCR, such as rhodopsin, in each of said wells; c) providing a number of mutants of the parent ligand, wherein the parent ligand being one that binds to the GPCR when the GPCR is residing in a particular conformation; d) bringing the mutants of the parent ligand in the wells into contact with the GPCR under conditions where the parent ligand would couple to the GPCR; and e) determining for each mutant whether the mutant ligand has a weaker or stronger binding ability as compared to the standard binding ability of the parent ligand and the GPCR by determining the amount of coupled mutant-GPCR complex in said wells. In an assay, rhodopsin binding of 403 mutants covering the complete arrestin sequence has been investigated. This information provides a functional 4th dimension to the crystal structures of inactive, preactivated and active arrestins. The resulting single amino acid resolution functional maps reveal a series of critical interactions in the polar core and along the C-tail of arrestin that are interrupted during arrestin activation. Our data further reveals several patches of amino acids that strongly reduce binding and act as direct binding interfaces to rhodopsin. This information in combination with computational molecular docking of active arrestin4 and light-activated rhodopsin allows to develop a model of the arrestin-rhodopsin complex. Combination of mutants allows modification of binding affinity and stability of the GPCR-ligand complex for diagnostic purposes or pharmacological intervention.

en

METHOD FOR DETERMINING MUTATEABLE LIGAND-GPCR BINDING AT SINGLE AMINO ACID RESOLUTION AND PAIRS OF MUTATED LIGAND AND GPCR

6210933_CH

23402192_DE,48867259_DE,48842184_CH

C07K 14/723,G01N 33/74,G01N2333/726,G01N2500/04

1999-04-29

Y

Mental abilities are labeled with terms such as memory, problem solving, spelling, etc. and can be measured by psychological measures such as recall score, etc. The physical correlates of brain functioning employ such measures as blood flow, electrophysiological events, etc. The relationship between these different scientific domains is called the mind-body problem. The submitted patent addresses the empirically obtained correlative relationships between a number of cognitive capabilities and the Quantitative EFG (QEEG) measures (coherence, phase, magnitude, etc.) during cognitive activation conditions. The QEEG measures reflect the electrophysiology of the gray matter of the brain underlying the scalp. The cognitive abilities addressed include memory for auditory (paragraphs, word lists) and visual (faces, Korean characters, reading material) information (immediate and delayed recall ability), spatial problem solving (Raven's Matrices), spelling, mathematical ability (multiplication, internal spatial addition), pronunciation of nonsense (not real) words, memory for autobiographical information, intentions and where objects have been placed. The patent addresses the different patterns which are responsible for effective cognitive functioning in the adult and child population as well as the normal response patterns across the tasks for the two groups. The relationship between cognitive success of auditory memory ability (paragraphs, word lists) was examined for the eyes closed and auditor, attention condition. The analysis reflected the positive relationship between certain QEEG variables across different cognitive conditions. The value of the patent resides in providing the specific QEEG parameters which are responsible for specitic cognitive abilities. These QEEG variables can be effectively changed through an operant biofeedback conditioning methodology.

en

Method for improving memory by identifying and using QEEG parameters correlated to specific cognitive functioning

7444817_US

7444818_US

A61B 5/374,A61B 5/377,A61B 5/4088

2011-06-06

N

Disclosed herein are nitrogen containing heteroaryl compounds of general formula (I), wherein the substituents are as defined within the specification, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful in the treatment or prophylaxis of psychotic disorders, schizophrenia, positive, negative and/or cognitive symptoms associated with schizophrenia, delusional disorder, substance-induced psychotic disorder, anxiety disorders, panic disorder, obsessive/compulsive disorders, acute stress disorder, generalized anxiety disorder, drug addictions, movement disorders, Parkinson's disease, restless leg syndrome, cognition deficiency disorders, Alzheimer's disease, multi-infarct dementia, mood disorders, depression, bipolar disorders, neuropsychiatric conditions, psychosis, attention-deficitihyperactivity disorder, attentional disorders, diabetes and related disorders, type 2 diabetes mellitus, neurodegenerative disorders, Huntington's disease, multiple sclerosis, stroke, spinal cord injury, solid tumors, hematological malignancies, renal cell carcinoma or breast cancer. Particularly preferred compounds include: 6-Cyclopropyl-N-(4-cyclopropylcarbamoyl-pyridin-3-yl)-3-(pyrimidin-5-ylamino)-pyridine-2-carboximidic acid, 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid (2,3-difluoro-6-methylcarbamoyl-phenyl)-amide, 3-(Pyrimidin-5-ylamino)-6-(tetrahydro-furan-3-yl)-pyrazine-2-carboxylic acid (1-methyl-5-methylcarbamoyl-1H-pyrazol-4-yl)-amide, 2-Isopropyl-5-(pyrimidin-5-ylamino)-pyrimidine-4-carboxylic acid (1-methyl-3-methylcarbamoyl-1H-pyrazol-4-yl)-amide, 6-Morpholin-4-yl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid (1-methyl-5-methylcarbamoyl-1H-pyrazol-4-yl)-amide, 6-Azetidin-1-yl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid (1-methyl-5-methylcarbamoyl-lH-pyrazol-4-yl)-amide.

en

NITROGEN CONTAINING HETEROARYL COMPOUNDS

8529723_

14999448_,25592984_,14978935_,15076670_,44338219_,25604298_,25589935_,25582945_

A61K 31/506,A61P 3/10,A61P 9/00,A61P 25/00,A61P 25/14,A61P 25/16,A61P 25/18,A61P 25/22,A61P 25/24,A61P 25/28,A61P 25/30,A61P 25/36,A61P 29/00,A61P 35/00,A61P 35/02,C07D 401/14,C07D 403/12,C07D 403/14,C07D 409/14,C07D 413/14,C07D 417/14

2000-01-25

N

The compounds of formula (I) may be used in medicaments for use as serotonin-reuptake inhibitors in the treatment of depression, obsessive-compulsive disorders, phobias, impulsive disorders associated with drug abuse, bulimia nervosa and anxiety. In formula (I): R1 and R2 are independently H or a linear or branched (C1-C6)alkyl group; A represents a linear or branched (C1-C6) alkylene group, a linear or branched (C2-C6)-alkenylene group or a linear or branched (C2-C6)alkynylene group; and G1 represents a grouping -N(R3)(R4), wherein R3 and R4 are independently H, a linear or branched (C1-C6)alkyl group, a (C3-C8)cycloalkyl group, a (C3-C8)cycloalkyl-(C1-C6)alkyl group in which the alkyl moiety is linear or branched, an optionally substituted aryl group, an optionally substituted aryl-(C1-C6)alkyl group in which the alkyl moiety is linear or branched, an optionally substituted heteroaryl group, or an optionally substituted heteroaryl-(C1-6) alkyl group in which the alkyl moiety is linear or branched; or G1 represents a heterocycloalkyl group, bonded to A by any one of the ring junctions and optionally substituted at any one of the ring positions by a linear or branched (C1-C6)alkyl group, a (C3-C8)cycloalkyl group, a (C3-C8)cycloalkyl-(C1-6)alkyl group in which the alkyl moiety is linear or branched, a nitrile group, a carboxy group, a linear or branched (C1-C6)alkoxy-carbonyl group, a carbamoyl group (optionally substituted by one or two substituents: linear or branched (C1-C6)alkyl, (C3-C8)cycloalkyl, optionally substituted phenyl and/or optionally substituted benzyl), an optionally substituted aryl group, an optionally substituted aryl(C1-C6)alkyl group in which the alkyl moiety is linear or branched, an optionally substituted heteroaryl group, or an optionally substituted heteroaryl-(C1-C6)alkyl group in which the alkyl moiety is linear or branched.

en

Cyano-indole serotonin-reuptake inhibitor compounds

12652651_

29362973_,33464495_,29335281_,33935964_,15088999_,13206567_

A61P 25/00,A61P 25/22,A61P 25/24,A61P 25/28,A61P 25/30,A61P 43/00,C07D 209/00,C07D 209/08,C07D 401/12,C07D 403/06,C07D 403/12,C07D 403/14,C07D 513/04

2018-02-23

N

REAL-WORLD VIEW OF LOCATION-ASSOCIATED SOCIAL DATA Particular embodiments maintain social-networking information associated with a user, wherein the user is represented by a user node in a social graph. One or more nodes of the social graph may be associated with respective locations. A request for social information related to a location may be received from a computing device. The request may comprise a location of the computing device, an orientation of the computing device, and an identifier for the user. A relevance score may be determined for one or more proximate nodes based on the request, the social-networking information associated with the user, and the location information for the respective proximate node. Each proximate node may be associated with at least one location within a threshold distance from the location of the computing device. Particular embodiments may provide social-networking information associated with at least one of the proximate nodes for display in conjunction with an image. 210 Maintaining social-networking information for a user 220 - ~\ Associating one or more nodes n a social graph with respective locations - ----- - . Receiving a request for social information related to a location, the request 230 comprising a location, an orientation, and user identity info 2 Determining a relevance score for each proximate node based on the request, 240 the user's social-networking information, and the proximate node's location 250 Ranki ng the proximate nodes by their respective relevance scores 260 Providing information associated with at least one proximate node for display on a computing device in conjunction with an image - .- -- - - - .- -- - - -- - -.-. .- - -- -- - --- . . . 270 iRceing indication of an action by the user associated with a proximate node Updating thesocilgraph in response to the received indication -- .

en

Real-world view of location-associated social data

12509098_US

50272993_,47666661_,47510529_

G06F 3/14,G06F 3/1423,G06Q 30/02,G06Q 50/01,G09G2370/022,G09G2370/16,H04L 65/403,H04L 67/306,H04L 67/52

2005-10-21

N

An expert decision-making method is emulated based on a history of behaviors by experts in a variety of observed situations. The history of behaviors is built up from observations of actions taken by experts in analyzing a plurality of situations. Situation data representative of a situation to be processed is received, and situation features are extracted from the situation data. Each situation feature is associated with an expert behavior method used to process the situation. A behavior method is recognized from a pattern of situation features. Recognizing a behavior method is based on feature/method separation data in multidimensional space of features into areas with each area associated with a method used by experts. Parameter values for parameters in the recognized behavior method are calculated based on the situation features. The calculation of parameter values is accomplished by recognizing parameter calculation rules and calculating the parameter values using the rules. A parameter calculation rule for each parameter in the behavior method is recognized from a pattern of situation features. Recognizing a parameter calculation rule is based on feature/parameter-calculation-rules separation data of multidimensional space of features into areas with each area associated with a parameter calculation rule used by experts. The recognized behavior method is executed on the situation data using the calculated parameter values to recommend a solution for the situation. The recommended solution has solution data representing a plan of action to provide the solution and remainder data representing unprocessed situation data. A test detects whether the remainder data is in a target range. If the remainder data is not in the target range, the actions to recommend a solution are repeated until the test detects the remainder data is in the target range.

en

MULTI-DIMENSIONAL, EXPERT, BEHAVIOR-EMULATION SYSTEM

39764503_RU,13092437_US,39764507_RU,39764505_RU,39764504_RU,39764502_US,39764506_RU

39764505_RU,39764504_RU,39764506_RU,39764502_US,39764503_RU,39764507_RU

G06N 5/047

2018-12-04

Y

A geographical multivariate flow data spatio-temporal autocorrelation analysis method based on a cellular automaton is provided. The spatio-temporality and complexity of geographical data are expressed by adopting an improved cellular automaton dynamic model, and a transformation rule and spatial heterogeneity of asynchronous evolution of a cell (geographic region) are considered to analyze geographical multivariate flow data of a non-linear structure based on a complex network more accurately. A cellular automaton model parameter is obtained more accurately by analyzing a cellular unit and extracting a plurality of influence factors, and is accurate and high in efficiency; the transformation rule obtained by using an ANN algorithm is more dynamic than the fixed transformation rule of the whole model, more describable, and conforms to an actual cellular changing situation; the correlation between cells is expressed by Moran's I to reflect a spatio-temporal distribution situation of geographical data better and more clearly, thereby facilitating subsequent simulation and prediction of spatio-temporal data model , and achieving the simulation and prediction more accurately. Fig. 2 rule/transformation tie st function Cell attribute neighborhood ni oho celsae information state ifatiut geographical space Fig 1 land use data of hi storical years image data randomly sampled obtaining transformation rule | lasification training data based on ANN algorithm influence factor data transformation rule data of distance at fdsac tatistical unit quantity of cell from city of cel fro - - - - (btaining through Cellular automatonfas downtown mirodneighborhood window) modelfas actual land use precision simulation result data assessment lan suang precision complies? yes spati-temoral Improved Moran's I -A ST I prediction result - data of future land use change Fig 2

en

Geographical multivariate flow data spatio-temporal autocorrelation analysis method based on cellular automaton

17942545_CN

63878429_,58940663_

G06K 9/00536,G06N 3/0481,G06Q 10/04,G06T2207/10032,G06T2207/20081,G06T2207/20084,G06T2207/30188,G06V 20/182,G06V 20/188

1981-03-09

Y

DYNAMIC DATA DISPLAY SYSTEM, AS FOR USE WITH EEG A dynamic display system is disclosed for discrete events of complex data that are carried by discrete electrical signals which indicate values in three coordinates as triads. One of the values may be an independent variable, e.g., time. A cathode ray tube display apparatus (television monitor) with a plane surface is actuated by format signals to exhibit a pictorial three-dimensional perspective field of reference somewhat in the figure of an elongate box viewed in perspective. The discrete electrical signals representative of data are processed to develop display signals to provide representative images in the field of reference. Specifically, as disclosed, the data events or elements are manifest in the form of lines or linear symbols that indicate coordinate values by symbol height and position. As disclosed, the independent variable, time, is scaled from an origin line in the field of reference to extend along the depth of perspective so that the linear symbols advance along the path of perspective to accomplish a dynamic display with the illusion of motion. The specific system herein displays EEG waves, effectively indicating the magnitude and frequency of individual brain waves with respect to time of occurrence. Consequently, a marching display is provided revealing fresh information together with a recent history of events in chronological order and in a concise and readily perceivable form. Additionally, recorded data may be later played back affording examination of a past history of EEG. Furthermore, color is utilized in the display to add still another dimension, stressing the ranges of frequency. A conventional television format is employed in which the linear symbols are formed along scanning lines of the television raster pattern, to provide a discrete and clear presentation.

en

DYNAMIC DATA DISPLAY SYSTEM, AS FOR USE WITH EEG

16038770_,16060158_

16038770_,16060158_

A61B 5/339,A61B 5/369,G01R 13/206,G01R 13/22,G09G 1/162

2000-07-25

N

Circuitry is provided for detecting threshold crossings of an input signal (V1), which is generally sinusoidal or otherwise periodic, but which is subject to either high-frequency noise which would cause erroneous multiple threshold crossings, or low-frequency noise which would cause erroneous failure to detect a threshold crossing. Two detection elements (U1, U2) detect the crossing of two different threshold values and produce detection signals reflecting whether the input signal is above or below their thresholds. For noisy input signals, these detection signals may be bouncy. High- (A, C) and low-true (B, D) versions of the detection signals are logically combined (U3, U4) to produce a first signal (E) which is active only while the input signal (V1) moves in one direction, and is masked from the active state while the input signal (V1) moves in the other direction. Likewise, a second signal (F) is produced which is active the opposite way. The first and second signals set and reset a latch (V5), whose output state represents the threshold crossing. Because of the logic masking of activity on the second signal due to noise on the input signal, once the first signal (E) puts the latch (V5) in one state, the latch (V5) is not immediately put back to the other state by the second signal (F). Rather, the latch (V5) remains in the one state until the input signal (V1) changes direction, at which time the first signal (E) is masked but the second signal (F) is enabled. Hysteresis circuitry (R1, R2, C1, C2, L1) allows the two detection elements to operate on different threshold values. Also, low-frequency noise is reduced by making the hysteresis circuitry frequency dependent. Preferably, the circuitry is low-pass (C2, L1), so that the hysteresis effect is reduced for higher-frequency input signals affected by lower frequency noise. <IMAGE>

en

Anti-glitch system and method for laser interferometers using frequency dependent hysteresis

116690_US

804240_US

G01B 9/02083

2000-03-20

N

The use of a drug for which the major clearance mechanism in humans is CYP2D6 mediated oxidative biotransformation selected from the group consisting of NMDA receptor antagonist containing a primary, secondary or tertiary alkylamine moiety and a neurokinin-1 (NK-1) receptor antagonist containing a primary, secondary or tertiary alkylamine moiety; and a CYP2D6 inhibitor in the manufacture of a medicament for the treatment of a human in need thereof wherein the drug and the inhibitor are not the same compound. The said drug for which the major clearance mechanism in humans is CYP2D6 mediated oxidative biotransformation may be further selected from the group consisting of mequitazine, tamsulosin, oxybutynin, ritonavir, iloperidone, ibogaine, delavirdine, tolteridine, promethazine, pimozide, epinastine, tramodol, procainamide, methamphetamine, tamoxifen, nicergoline, fluoxetine, alprenolol, amiflamine, amitriptyline, aprindine, brofaromine, buturalol, cinnarizine, clomipramine, codeine, debrisoquine, desipramine, desmethylcitalopram, dexfenfluramine, dextromethorphan, dihydrocodine, dolasetron, encainide, ethylmorphine, flecainide, flunarizine, fluvoxamine, guanoxan, haloperidol, hydrocodone, indoramine, imipramine, maprotiline, methoxyamphetamine, methoxyphenamine, methylenedioxymethamphetamine, metoprolol, mexiletine, mianserin, minaprine, procodeine, nortriptyline, N-propylajmaline, ondansetron, oxycodone, paroxetine, perhexiline, perphenazine, phenformine, promethazine, propafenone, propanolol, risperidone, sparteine, thioridazine, timolol, tomoxetine, tropisetron, venlafaxine or zuclopenthixol; and wherein the CYP2D6 inhibitor may be selected from the group consisting of quinidine, ajmalacine, sertraline, venlafaxine, dexmedetomidine, tripennelamine, premethazine, hydroxyzine, halofrintane, chloroquine, moclobemide or St John's wort.

en

Use of CYP2D6 inhibitors in combination therapies

12651345_

33978748_

A61K 31/137,A61K 31/445,A61K 31/4745,A61K 31/498,A61K 31/542,A61K 31/7056,A61K 36/38,A61K 45/06,A61P 43/00

2020-07-06

N

An objective of the present invention is to provide a brain-computer interface text input apparatus which allows an ERP based text input system to rapidly recognize correct letter (target text) and maintain high recognition rate of a system using probability based visual simulation dynamic optimization technology presenting optimized stimulation to a user based on classifier results updated each time minimal stimulation is repeated, a method thereof. The brain-computer interface text input apparatus using probability based visual simulation dynamic optimization technology comprises: a memory to store a program for performing a brain-computer interface text input method; and a program to executing the program. The processor performs: a first step of presenting a visual stimulation group configured by a character array including a plurality of characters as a predetermined stimunaiton number by executing the program and measuring a brain signal of a measured person generated corresponding to each character to detect a probability of a target character by each character; a second step of excluding an optional character from a vitual stimulation group when a probability of a detected optional character is significantly lower than a probability of remaining characters to select the remaining characters as a candidate character group; a third step of determining wheter to continuously measure a brain signal according to a reset dynamic stopping criterion; and a fourth step of relocating a candidate character group as each flash group configuring the visual stimulation group when it is determined to continously measure the brain signal. Until stopping measuring of the brain signal in the third step, the first step to the fourth step are repeated N times. One of candidate character groups in (N-1) times is determined as a target character.

en

- BRAIN-COMPUTER INTERFACE SPELLING APPARATUS AND METHOD USING DYNAMIC OPTIMIZATION TECHNOLOGY OF VISUAL STIMULATION BASED ON PROBABILITY

64807294_KR

59317410_,70926863_,70253334_,70327859_

A61B 5/30,G06F 3/015,G06F 3/0233

1999-10-26

Y

The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins. The rat cerebellum-derived and human brain-derived G protein coupled receptor proteins and the like are useful: (1) for determination of a ligand to the receptor protein of the present invention (ligand peptide of the present invention) (agonist), (2) as an agent for the prevention and/or treatment of diseases associated with dysfunction of the G protein coupled receptor protein of the present invention, (3) as a genetic diagnostic agent, (4) for quantification of a ligand to the G protein coupled receptor protein of the present invention, (5) for screening of a compound (agonist, antagonist, etc.) that alters the binding property between the G protein coupled receptor protein of the present invention and a ligand (ligand peptide of the present invention), (6) as a agent for the prevention and/or treatment of various diseases, comprising a compound (agonist, antagonist, etc.) that alters the binding property between the G protein coupled receptor protein of the present invention and a ligand (ligand peptide of the present invention), (7) for quantification of the receptor protein, its partial peptide or salts of the present invention, (8) for neutralization by antibodies to the receptor protein, its partial peptide or salts of the present invention and (9) for preparation of a non-human animal bearing the DNA encoding the G protein coupled receptor protein of the present invention.

en

NOVEL G PROTEIN-COUPLED RECEPTOR PROTEINS, DNAS THEREOF AND LIGANDS TO THE SAME

7724_JP

4052149_JP,4052150_JP,4052151_JP,1111107_JP,945306_JP,595547_JP

A61K 38/00,A61P 15/06,A61P 35/00,C07K 14/705,G01N 33/566,G01N2333/726,G01N2500/02

1971-12-15

Y

An empathy game comprises several series of cards and means for counting empathic responses. The cards of one series are identity cards and each card of this series bears indicia corresponding to a role to be taken by a player in the course of play. The cards of another series are situation cards and each card of this series bears indicia corresponding to a situation with which the role-taking player is confronted. Two series of reaction cards are provided from which the role-taking player may select his reaction to the situation presented. Prior to the start of play, one series of reaction cards is dealt to a first player and the other series of reaction cards is dealt to a second player. To play the game, a player takes a card from a deck formed from the identity cards and another card from another deck formed from the situation cards, displaying both cards. The first player then chooses, and plays face down, a reaction card from one of the series of reaction cards previously dealt to him as his reaction to the situation presented by the situation card in the role indicated by the identity card. The other player then selects a reaction card from his set of reaction cards which he believes to correspond to the reaction of the first player. If he judges correctly, one accurate empathic reaction is scored on the counting means. The counting means may include a pair of rods which extend transversely across a playing board and are advanceable lengthwise therealong. Notched flanges extending lengthwise along the edges of the board are adapted to receive and disengageably hold the ends of the rods at discrete locations along the board. Transparent sheets extending from each end of the board with their free ends attached to said rods cover areas corresponding to the number of accurate scores as the rods are advanced from notch to notch.

en

EMPATHY GAME

38831848_

38831848_

A63F 1/00,A63F 9/00,Y10S 273/26

2010-11-08

N

A system and method for gathering, processing, and analyzing data to determine the risk associated with driving behavior is disclosed. A crash risk factor can be assigned to a driver behavior in a database (710), where the crash risk factor has a value related to a crash scenario. The crash scenario can be a crash type or a crash severity. A trip length input for the vehicle can be received from a sensor (720). The trip length input can be a distance traveled for the trip or a time duration for the trip. The trip length can be segmented into a plurality of intervals. The interval can be a distance segment of the trip or a time segment of the trip. The sensor can either be an integrated vehicle sensor integrated with the vehicle or a portable sensor contained in the vehicle. The portable sensor contained in the vehicle can be a mobile phone or other mobile communication device. The integrated vehicle sensor can be an on-board sensor that is configured to communicate with the portable wireless device. A base-line value for the crash risk factor for each interval of the trip can be determined (730) where the base-line value represents a value for safe driving without the crash risk factor. The occurrence of driver behavior corresponding to the crash risk factor for each interval can be determined. A crash risk mileage value for each interval of the trip can be calculated (740) by multiplying the base-line value by an interval length and the crash risk factor applicable to the interval. A total crash risk mileage value for the trip can be determined by combining (750) the crash risk mileage value for each interval. At least one of the total crash risk mileage value and the driver behavior for the trip can be transmitted (760) to a remote server with a mobile communication device to allow driver behavior-related risk to be analyzed.

en

METHOD FOR GATHERING, PROCESSING, AND ANALYZING DATA TO DETERMINE THE RISK ASSOCIATED WITH DRIVING BEHAVIOR

12332727_US,11727168_US,12332729_US,12332728_US

12332727_US,12332729_US,12332728_US,11727168_US

G06Q 40/00

1999-04-22

Y

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein A is C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, arylC1-6alkyl, aryl, S(O)pR1, OR1 or NR1R12; B is optionally substituted 5- or 6-membered heteroaromatic ring or C(O)NR10R11; R1 is hydrogen, optionally substituted C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl or C3-6cycloalkenyl, optionally substituted aryl, arylC1-6alkyl, arylC2-6alkenyl or arylC2-6alkynyl or an optionally substituted 5- or 6-membered heteroaromatic ring; R2 and R3 are hydrogen or C1-6alkyl; R4 is hydrogen, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, aryl or CH2(CO)mNR8R9; R5 is NR6R7, C1-6alkyl or C1-6alkoxy; R6 is independently as defined for R4; R7 is aryl optionally substituted by halogen, nitro or cyano; R8 is hydrogen, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkenyl, C2-6alkenyl, C2-6alkynyl; arylC1-6alkyl, arylC2-6alkenyl or arylC2-6alkynyl optionally substituted on the aryl ring by halogen, nitro or cyano; thiophene or pyridine; R9 is C1-6alkyl; C2-alkenyl; C2-6alkynyl; or phenyl optionally substituted by one, two or three substituents independently chosen from halogen, CF3, OCH3, nitro and cyano; R10 and R11 are individually hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl or C3-8cycloalkyl or R10 and R11, together with the nitrogen atom to which they are attached, form a saturated 4 to 8 membered ring optionally containing an oxygen atom or a further nitrogen atom as a ring member, the further nitrogen atom being unsubstituted or substituted by C1-4alkyl, C2-4alkenyl or C2-4alkynyl; R12 is hydrogen or C1-6alkyl; m is zero or 1; p is zero, 1 or 2; q is 0, 1 or 2; and r is 0, 1 or 2; the preparation of these compounds, their use in enhancing cognition in disease states, particularly Alzheimer's disease, and methods of treatment using them.

en

Substituted thienobenzisoxazole derivatives for enhancing cognition

7295867_GB

5669580_GB,6517959_GB

C07D 498/04

1992-04-15

Y

Novel compounds of the formula <IMAGE> wherein n is an integer from 1 to 4 inclusive; R1 represents a mono-or disubstituent of hydrogen, lower alkyl(C1-C3), lower alkoxy(C1-C3), halogen, nitro or trifluoromethyl; R2 is cyano, carboxamido, ethyl carboxylate or halogen; R3 is hydrogen, straight or branched chain lower alkyl(C1-C3), alkenyl(C2-C3), alkynyl(C2-C3), cycloalkyl(C3-C6), hydroxyalkyl(C1-C3), dimethylaminoalkyl(C1-C3), ethylcarboxylate, alkyl(C1-C13)carbonyl, 1-(methylethyl)acetamide, cyclohexylethyl, phenyl, mono-or disubstituted phenyl (wherein the phenyl substituent is halogen, trifluoromethyl, lower alkyl(C1-C3) or lower alkoxy(C1-C3)), benzyl, mono-or disubstituted benzyl (wherein the benzyl substituent is halogen, lower alkyl(C1-C3), lower alkoxy(C1-C3) or trifluoromethyl), benzoyl, 4-methoxybenzoyl, straight or branched chain alkyl(C2-C3)phenyl, 4-chlorophenylphenylmethyl, 1,3-benzodioxol-5-ylmethyl, 1,3-benzodioxol-5-yl, 2-furanylcarbonyl, 2-pyrimidinyl, 2-pyridinyl, 4-morpholinyl-2-oxoethyl, 1-pyrrolidinyl-2-oxoethyl, bis(4-fluorophenyl)methyl, phenylcarboxamido, mono- and disubstituted phenylcarboximido (wherein the phenyl substituents is halogen, trifluoromethyl or lower alkyl(C1-C3)), adamantanoyl, 3-phenoxypropyl,5-chloro-2-methoxyphenylacetamide, (2-oxo-1-pyrrolidinyl)-2-butynyl, phenylmethylcarboxylate, or (2-phenyl-2_H-1,2,3-triazol-4-yl)methyl; R4 and R5 are independently hydrogen or lower alkyl(C1-C3); the dotted line between positions 6 and 7 of the pyrimidine ring represents the presence or absence of a double bond; and the pharmacologically acceptable salts thereof: methods of producing them; therapeutic compositions containing them: and methods of using them to treat anxiety, hypertension, depression, senile dementia, cognitive defects and other neural behavior problems in warm-blooded animals.

en

Method of treating cognitive and related neural behavioral problems

5243642_US

6546548_US,6348835_US,7056552_US

C07D 487/04

2013-02-28

N

The present invention relates to a system for measuring a consumer emotion model and, particularly, to a system for providing a guideline for product production or service provision by measuring an emotion model of a consumer being targeted. The system for measuring a consumer emotion model, according to the present invention, comprises: a questionnaire provision unit (110) for providing a questionnaire for extracting design elements, consumer psychology elements and activity elements; a questionnaire response reception unit (120) for receiving, from sample consumers, answers corresponding to a report; a score calculation unit (130) for calculating total scores for each item category by multiplying the weighted values for each item with the inputted answers, and for calculating percentage values of the total scores; and an emotion model determination unit (140) for matching consumer emotions to one emotion model among preset emotion models on the basis of the calculated percentage values for each item category. The system for measuring the consumer emotion model, according to the present invention, understands a consumption propensity or the preferential tendencies of a consumer and, especially, is necessary for quantitatively understanding the emotions of emotional and various consumers. To this end, the system calculates a result value by giving a weighted value according to a correlation between the respective questionnaires through the questionnaire on consumer psychology reflecting design elements and consumer psychology and activity elements, and quantitatively measures the types of consumer emotions on the basis of a maximum value element of the extracted result value, so as to classify the consumer emotions by the emotion model, thereby enhancing design competitiveness and improving the added value in the future.

en

SYSTEM FOR MEASURING CONSUMER EMOTION MODEL

48740286_KR

48819943_KR

G06Q 30/02,G06Q 50/30

2017-10-12

Y

2016P01192EP Abstract Computer system (100), computer-implemented method and computer program product are provided for providing SPaT messages to a vehicle (501) wherein the SPaT messages include reliable timing parameters to influence the operation of the vehicle,. The system has an interface component (110) configured to receive switching state data from one or more traffic lights wherein switching state data (SD1) of a particular traffic light includes signal states comprising at least a pass-state (SD1p) and a stop-state (SD1s) of the particular traffic light at respective sampling time points, and further configured to provide a SPaT message (402) to the vehicle. Further, a signal analyzer component (140) of the system is configured to perform a sequence of analysis steps for predefined prediction intervals having the same length as the sampling intervals by: identifying the current signal state (SD1s, SD1p) of the one or more traffic lights (S1 to S4); deriving, from a statistical model (130) trained on the basis of historic state transitions of the one or more traffic lights, probabilities for future state transitions from the current state into a different state for one or more future prediction intervals; and determining a minimum end time for a state transition from the current state to the different state as the start of the nearest future prediction interval where the probability of the current state falls below a predefined first threshold value. A message composer component (150) of the system is configured to compose the SPaT message including the determined minimum end time. S1 SD~p SD~s 501 S3| S4 SD1s SD~p S2 SPaT Interface 110 100 I Training Message Imodule120 I composer moue10Probability15 module 141 Statistical minEdTie model 130 odule142 MaxEndTime module143 LikelyTime module144 signal analyzer 140

en

COMPUTER SYSTEM AND METHOD FOR DETERMINING RELIABLE VEHICLE CONTROL INSTRUCTIONS

63931916_DE

57095077_,55018079_

G05D 1/0088,G06N 5/04,G06N 7/08,G06N 20/00,G08G 1/0129,G08G 1/0141,G08G 1/091,G08G 1/096716,G08G 1/096725,G08G 1/096783

2019-05-03

Y

The present invention relates to a brain-computer interface system and a method for analyzing a brainwave signal expressed by motor imagery. The method comprises: (a) a step of acquiring a source brainwave signal expressed in motor imagery during a preset measurement time, and filtering the source brainwave signal in a base frequency band associated with motor imagery to generate a brainwave signal; (b) a step of performing an optimal performance search algorithm for calculating a time range and an optimal expression frequency domain of a brainwave feature pattern for the brainwave signal to divide the brainwave signal into preset frequency intervals to convert the brainwave signal into n sub-band signals and then detect a maximum performance time range for each of the sub-band signals; (c) a step of extracting a brainwave feature based on the maximum performance time range for each sub-band signal, using the extracted brainwave feature to generate a classification model for recognizing a motion imagined or intended by a user, and then calculating the accuracy for a classification result of the classification model to perform classification performance evaluation; and (d) a step of detecting an optimal sub-band signal having the highest performance based on result values of the classification performance evaluation, and a maximum performance time range linked to the optimal sub-band signal to provide the optimal sub-band signal and the maximum performance time range in an optimized motor imagery frequency-time domain for each user. The optimal performance search algorithm performs performance evaluation in a plurality of time ranges generated by setting a time search window having a preset time range and applying the time search window at preset critical time intervals in the measurement time of each sub-band signal.

en

- BRAIN-COMPUTER INTERFACE SYSTEMS AND METHOD FOR ANALYSING BRAIN WAVE SIGNALS EXPRESSED BY MOTOR IMAGERY

64807294_KR

75878015_,59317410_,70327859_,74942703_

A61B 5/372,A61B 5/7225,G06F 3/015,G06N 20/00

2015-11-04

N

Figure 1 shows the components of the measuring apparatus for recognizing and locating emotions and thoughts by measuring the infrared pulse radiation in the sequence of the measured value preprocessing: localization tube 1, infrared detector 2, amplifier 3, analogue/digital conversion 4, analysis program 5 and display 6, wherein the components of the measuring apparatus have the following features: the localization tube 1 records only the infrared pulses which are emitted by a small surface and are produced by changes in the body heat of a creature, partially repeatedly reflects said infrared pulses at the inner wall and focuses said pulses on the infrared detector 2; the infrared detector 2 which is designed to be able to receive only AC voltage signals and not DC voltage signals converts the infrared beams into electrical signals; the amplifier 3 amplifies these signals; the signals are digitized during the analogue/digital conversion 4; the analysis program 5 creates time signals, absolute value spectra and differential spectra for the total measuring time or for time sections for different mental states of the creature being investigated and creates a characteristic mental spectrum in the pulse frequency range of approximately 0.01 to 10 Hz; the results for the different mental states of the creature being investigated can be seen on the display 6 and can be compared, with the result that different emotions such as joy or sorrow can be recognized, for example. In addition to the measuring apparatus, it is possible to use a transmitter which flashes on a small body surface and the light pulses from which contain infrared components. This has the advantage of amplifying pulse frequencies which have already occurred and of allowing the pulse frequencies which have not yet appeared during mental activity to emerge.

en

APPARATUS FOR RECOGNIZING AND LOCATING EMOTIONS AND THOUGHTS BY MEASURING THE INFRARED PULSE RADIATION

40543460_DE

40543460_DE

A61B 5/0064,A61B 5/0075,A61B 5/0077,A61B 5/015,A61B 5/0261,A61B 5/165,A61B 5/7225,A61B 5/725,A61B 5/7278,A61B 5/742,A61B2562/0233,A61B2562/0271,A61B2576/00

2016-04-29

N

The present invention relates to a system for detecting a brain nerve activity signal of an animal model, and an automatic control method using the same. The system for detecting a brain nerve activity signal of an animal model comprises: a pair of light sources which are installed on one side of a sensing unit and are spaced from each other at a predetermined interval; a photographing unit, installed on the top of the light sources, for photographing the light sources at a constant cycle for a preset time period and obtaining a plurality of images of the light sources; a rotational connector which is rotatably disposed between the sensing unit and a brain nerve activity signal storage unit and is electrically connected to the sensing unit and the brain nerve activity signal storage unit; a rotational force provision means of which one end is connected to one end of the rotational connector so as to provide a rotational force to the rotational connector; a photographing unit, installed on the top of the light sources, for photographing the light sources and obtaining images of the light sources; and a processor for analyzing the plurality of images obtained by the photographing units, computing rotation information with respect to the rotational direction and rotational angle of the light sources, and controlling the rotational force provision means on the basis of the computed rotation information. The present invention rotates, in response to the number of rotations of an animal model, the rotational connector connected to a cable even when the animal model, which can freely move, rotates and the cable is rotated together. Thus, the present invention has effects of preventing the cable from being twisted and also preventing the movement of the animal model from being interrupted due to the twisting of the cable.

en

SYSTEM FOR DETECTING BRAIN NERVE ACTIVITY SIGNAL OF ANIMAL MODEL, AND METHOD FOR DETECTING BRAIN NERVE ACTIVITY SIGNAL OF ANIMAL MODEL USING SAME

68575668_KR

63984970_KR,69682799_KR

A61B 5/00

2018-09-18

Y

TECHNIQUES FOR CORRECTING LINGUISTIC TRAINING BIAS IN TRAINING DATA In automated assistant systems, a deep-learning model in form of a long short term memory (LSTM) classifier is used for mapping questions to classes, with each class having a manually curated answer. A team of experts manually create the training data used to train this classifier. Relying on human curation often results in such linguistic training biases creeping into training data, since every individual has a specific style of writing natural language and uses some words in specific context only. Deep models end up learning these biases, instead of the core concept words of the target classes. In order to correct these biases, meaningful sentences are automatically generated using a generative model, and then used for training a classification model. For example, a variational autoencoder (VAE) is used as the generative model for generating novel sentences and a language model (LM) is utilized for selecting sentences based on likelihood. RECEIVE A QUERY FROM A USER 502 GENERATE A SET OF QUERIES ASSOCIATED WITH THE RECEIVED QUERY USING A LONG SHORT-TERM MEMORY VARIATIONAL AUTOENCODER (LSTM-VAE) AT AN INFERENCETME 504 DISCARD ONE ORMOREQUERES COMPRISING CONSECUTIVELY REPEATING WORDS FROM THE SET OF GENERA TED QUERIES TO CREATE A SUBSET OF THE GENERATED QUERIES SELECT ONE OR MORE QUERIES FROM TIHE SUBSET OF THE GENE RATED QUERIES BASED ON LIKELIHOOD VIA A L ANGUAGE CLASSIFY THE ONE OR MORE SELECTED QUERIES AS QUERIES THAT EXISTS IN THE FIRST SET OF TRAINING DATA AND NEW 510 QUERIES USING A FIRST CLASSIFIER MODEL AUGMENT THE FIRST SET OF TRAINING DATA WIT H THENEW 512 QUERIES TO OBTAIN A SECOND SET OFT RAINING DATA TRAIN A SECOND CLASSIFIE R MODEL USING THE SECOND SET OF TRAINING DATA, THUS CORRECTING LINGUISTIC TRAINING BIAS 514 IN TRAINING DATA

en

Techniques for correcting linguistic training bias in training data

6182385_IN

71016239_,48992766_,15030891_,53816745_

G06F 16/2455,G06N 3/0445,G06N 3/0454,G06N 3/0472,G06N 3/08,G06N 5/046

2019-12-13

N

The present invention relates to a system for the automatic diagnosis of uterine cervical cancer, wherein the system classifies and machine-learns uterine cervix data, necessary for automatically diagnosing uterine cervical cancer, according to accurate criteria, and automatically diagnoses uterine cervical cancer on the basis of the machine learning. The system is characterized by including: a training data generation unit which, in a learning mode, classifies unclassified captured image data on the uterine cervix, transmitted from an external device or a storage unit, according to a multi-stage combination of classification criteria, and generates new training data for each classification criterion; a captured image preprocessing unit which pre-processes captured uterine cervix images; auterine cervical cancer diagnosis unit including a machine-learning model which is for uterine cervical cancer and learns features of the training data generated for each classification criterion inthe learning mode, wherein, in a diagnosis mode, the machine-learning model generates, for the captured and pre-processed uterine cervix image, diagnosis information about whether uterine cervical cancer has developed; a screen display control unit which displays the diagnosis information, and displays and outputs a user interface screen through which evaluation information can be input by a radiologist; a re-training data generation unit which extracts information necessary for re-training from the evaluation information input through the user interface screen, and requests re-training of themachine-learning model; and a diagnosis and evaluation information storage unit which stores the diagnosis information about whether uterine cervical cancer has developed, and the evaluation information input through the user interface screen.

en

SYSTEM FOR AUTOMATIC DIAGNOSIS OF UTERINE CERVICAL CANCER

79738434_

73214403_

A61B 5/0033,A61B 5/7275,G16H 30/40,G16H 50/20,G16H 50/70

2016-09-14

N

The invention relates to carbohydrate ligands and moieties, respectively, mimicking glycoepitopes comprised by glycosphingolipids of the nervous system, particularly glycoepitopes comprised by glycosphingolipids of the cerebroside, the globoside-, the ganglioside- and the sulfoglucuronyl paragloboside type, which are bound by anti-glycan antibodies associated with neurological diseases. The invention further relates to the use of these carbohydrate ligands/moieties, in diagnosis as well as for the treatment of neurological diseases associated with anti-glycan antibodies. In particular, the invention relates to compounds of formula (I) and (II) and to therapeutically acceptable polymers comprising a multitude of these compounds, including polymers with loading of one compound of formula (I) or (II) or combinations of several compounds of formula (I), and/or (II). The compounds of formula (I) are defined as: formula (I), wherein RI1 is Z or (AA) or (BB) or (CC) or (DD); wherein RI2 is H, SO3H, or (EE) or (FF) or (GG) or (HH) or (JJ) or (KK) or (LL), wherein RI3 is H or (MM); wherein RI4 is H or (NN) or (OO), wherein RI5 and RI6 are independently H or (EE); wherein RI7 is H or (EE) or (FF) and compounds of formula (II) are defined as: formula (II), wherein RII1 is Z or (PP), wherein RII2 is Z or (QQ) or (RR) or (SS) or (TT), wherein Z is -N(Ra)-A-B-CH2-(CH2)q-SH, wherein Ra is H, C1-C4-alkyl, C1-C4-alkoxy, CH2C6H5, CH2CH2C6H5, OCH2C6H5, or OCH2CH2C6H5; A is C1-C7-alkylene, C1-C7-alkoxy, C1-C4-alkyl–(OCH2CH2)pO–C1-C4-alkyl, or C1-C7-alkoxy-Rb, wherein Rb is an optionally substituted aryl or an optionally substituted heteroaryl, and wherein p is 0 to 6, preferably p is 1, 2 or 3, and further preferably p is 1; B is NHC(O), S or CH2; q is 0 to 6, preferably q is 1, 2, 3 or 4, and further preferably q is 1 or 2.

en

CARBOHYDRATE LIGANDS THAT BIND TO ANTIBODIES AGAINST GLYCOEPITOPES OF GLYCOSPHINGOLIPIDS

47704062_CH

55256472_CH,13469724_CH,55601845_CH,51907891_CH,51984056_CH

A61P 25/00,C07H 15/12,C08G 69/48

2017-12-25

N

The invention can be used to obtain information about a psychophysiological state of a person in different fields, including biometrics, psychophysiology, functional diagnostics and psychology. For this purpose, the following primary psychophysiological characteristics are determined: an energy characteristic, as an indicator of the energy given off by a person, and an information characteristic, as an indicator of the efficiency of information exchange. A person's current psychophysiological state is determined in real time, and additionally the pattern of change in the person's current psychophysiological state over a monitoring period is evaluated. The evaluation of a change in the person's psychophysiological state is carried out in a system of coordinates formed by the primary psychophysiological characteristics, where the pattern of change in the person's psychophysiological state over the entire monitoring period is evaluated according to the change in direction of a vector characteristic in the form of the path of a graph consisting of consecutively interconnected directed segments characterizing the change in direction and magnitude of the primary psychophysiological characteristics for each recorded time interval of the monitoring period. The present method provides an increase in the functional possibilities of a method of evaluating a person's psychophysiological state as a result of the additional analysis of psychophysiological characteristics based on information about the pattern of change in the direction of a vector of the person's unconscious response during the monitoring process, and establishment of a correlation between the change in direction of the psychophysiological response vector and a set of primary physiological parameters determining the person's psychophysiological state.

en

METHOD OF EVALUATING A PSYCHOPHYSIOLOGICAL STATE OF A PERSON

74676518_RU

74790701_RU

A61B 5/11,A61B 5/165,A61B 5/72

2020-08-28

N

A schizophrenia classification and identification method, an operation control apparatus, and medical equipment. The method comprises: acquiring a data sample, and preprocessing the data sample to obtain a functional connection matrix (S100); inputting the functional connection matrix into a convolutional layer of a multi-kernel capsule network, providing several convolutional kernels of different sizes in the convolutional layer, and extracting connection information from the functional connection matrix by means of each convolutional kernel to obtain capsules, wherein the capsules are represented in the form of vectors, the directions of the vectors represent attributes, and the lengths of the vectors represent the probabilities of the corresponding attributes (S200); inputting the capsules into a capsule layer of the multi-kernel capsule network, iteratively updating a weighting matrix on the basis of a random capsule inactivation strategy and by using a routing protocol algorithm, and then converting the capsules into prediction vectors by means of the weighting matrix (S300); carrying out weighted summation on the prediction vectors and then inputting same into a classification capsule layer of the multi-kernel capsule network, and according to an edge loss function, updating a network connection weight value by using a backpropagation algorithm (S400); and performing training according to the multi-kernel capsule network to obtain a final weight value, and then performing calculation according to the final weight value to obtain a classification result of the data sample, so as to classify schizophrenia therefrom. The method can realize the classification and identification of schizophrenia, improve the classification accuracy, and improve the performance and robustness of a classification method.

en

SCHIZOPHRENIA CLASSIFICATION AND IDENTIFICATION METHOD, OPERATION CONTROL APPARATUS, AND MEDICAL EQUIPMENT

79299765_CN

18021299_CN,18903096_CN

A61B 5/055,A61B 5/165,A61B 5/7267,G06N 3/0454,G16H 50/20,G16H 50/70

2015-03-04

Y

FIELD: information technology.SUBSTANCE: group of inventions refers to a computer-implemented method and system for testing and/or training user functions or skills in the visual, cognitive and/or visual coordination of hand movements. Use on the computer a method and system for testing and/or training visual, cognitive and coordination functions using a computer or data processing device, having a touch screen. At the same time at least one linear form object is represented on the touch screen and the user must draw with repetition the line(s) of the represented object, and the line(s) drawn with a repetition is evaluated, in order to determine a characteristic or parameter relating to deviations and / or correspondence between the represented at least one linear form object and the line(s), drawn by the user with repetition. Characteristic is determined on the basis of the following evaluation steps: estimate the average distance in the image elements for the image elements, drawn with the removal from the nearest original image element; estimate the average variance, how far the drawing has been consistently performed; estimate the length of the curve as compared to the length of the original curve; estimating the average inverse distance in the image elements, containing information on how far the original image element is from the nearest drawn image element; estimate the time, required for drawing with repetition of the line(s) of the represented object.EFFECT: group of inventions allows to test or train the cognitive functions of the user by using a system for testing and/or training visual, cognitive and coordination functions, taking into account the assessment or determination of conformity/deviation by linear or nonlinear summation or integration of collected values by deviation.18 cl, 9 dwg

en

COMPUTER METHOD AND SYSTEM OF TESTING OR TRAINING OF USER COGNITIVE FUNCTIONS

64997266_US

67225369_DE,64997266_US

A61B 3/02,A61B 3/032,A61B 5/103,A61B 5/16,A61B 5/168,G06T 11/203,G09B 7/02,G09B 11/00,G09B 11/04,G09B 19/003

1987-03-10

Y

OBSTRUCTED-FIELD-INDICIA-SENSING DEVICE An apparatus for monitoring the phasing relationship of a moving web of material of the type having a repeating series of graphics patterns thereon which repeat at ordinarily constant distance repeat length intervals of web travel and which contain separate repeating indicia portions which define a repeating indicia set which are positioned in a repeating indicia path extending longitudinally of the web comprising: an indicia detection device for providing an indicia detection pulse signal; a web travel sensing device for providing a web movement signal; an indicia profiling device for processing the indicia pulse signal and the web monitoring signal for generating a unique indicia image for each of the repeating indicia in a selected repeat length portion of the web; an indicia image storage device for identifying and storing the indicia images from a first selected repeat length portion of the web; a register indicia designation device for initially designating one of the repeating indicia to be register indicia; a register indicia sensing device for providing a register indicia pulse signal having pulses which in normal operation corresponds to the detection of the selected register indicia; a register indicia verification device for verifying that the repeating indicia which is in synchronization with said register indicia pulse signal is the currently designated register indicia; and a register indicia correction device for designating the indicia that is in synchronization with said register indicia pulse signal as the register indicia and replacing the previously designated register indicia therewith when the indicia image of the current register indicia is not verified to be the indicia which is in synchronization with the register indicia pulse signal.

en

OBSTRUCTED FIELD INDICIA SENSING DEVICE

16169054_US

16169054_US,16169055_US

B65H 23/046,G06K 7/016,G06K 7/14

2019-11-14

N

Disclosed are a facial recognition model evaluation method and apparatus, and a storage medium and a computer device, relating to the technical field of artificial intelligence. The method comprises: constructing n positive test samples (S102); constructing n negative test samples (S104); inputting the n negative test samples into a facial recognition model (S106); receiving a feature vector corresponding to a scene photograph and a feature vector corresponding to a base image which are output by the facial recognition model, calculating the cosine similarity between the feature vector corresponding to the scene photograph and the feature vector corresponding to the base image, and determining the similarity between the scene photograph and the base image of each negative test sample of the n negative test samples according to the cosine similarity obtained through calculation (S108); sorting the n negative test samples according to the similarity between the scene photograph and the base image of each negative test sample of the n negative test samples to obtain a sorting result (S110); acquiring a preset error recognition rate (S112); determining a target similarity according to the preset error recognition rate and the sorting result (S114); calculating a passing rate of the n positive test samples according to the target similarity (S116); generating an evaluation result of the facial recognition model according to the passing rate of the n positive test samples, wherein the evaluation result is used for evaluating the recognition accuracy of the facial recognition model (S118); and outputting the evaluation result of the facial recognition model (S120). The method can solve the problem in the prior art of being unable to evaluate a facial recognition model according to the recognition accuracy.

en

FACIAL RECOGNITION MODEL EVALUATION METHOD AND APPARATUS, AND STORAGE MEDIUM AND COMPUTER DEVICE

63942312_CN

76989324_CN

G06K 9/00

2007-04-20

N

The invention is directed to the use of at least one CB<SUB>x</SUB> modulator wherein the CB<SUB>x</SUB> modulator is selected from the group consisting of CB<SUB>1</SUB> agonists; CB<SUB>2</SUB> agonists; CB<SUB>2 </SUB>partial agonists; CB<SUB>2</SUB> antagonists; CB<SUB>2</SUB> inverse agonists; and dually acting compounds which are both a CB<SUB>1</SUB> agonist and a CB<SUB>2</SUB> agonist; and mixtures thereof, as K<SUB>ATP</SUB> channel modulator for the prophylaxis, treatment, delayed progression, delayed onset and/or inhibition of a variety of disease conditions including obesity, diabetes mellitus, metabolic syndrome, syndrome X, insulinoma, familial hyperinsulemic hypoglycemia, male pattern baldness, detrusor hyperreactivity, asthma, neuroprotection, epilepsy, analgesia, cardioprotection, angina, cardioplegia, arrhythmia, coronary spasm, peripheral vascular disease, cerebral vasospasm, appetite regulation, neurodegeneration, pain - including neuropathic pain and chronic pain - and impotence in mammals and humans. The invention further relates to methods of treating, preventing, delaying progression of, delaying onset of and/or inhibiting a variety of disease conditions including obesity, diabetes mellitus, metabolic syndrome, syndrome X, insulinoma, familial hyperinsulemic hypoglycemia, male pattern baldness, detrusor hyperreactivity, asthma, neuroprotection, epilepsy, analgesia, cardioprotection, angina, cardioplegia, arrhythmia, coronary spasm, peripheral vascular disease, cerebral vasospasm, appetite regulation, neurodegeneration, pain - including neuropathic pain and chronic pain - and impotence in mammals and humans comprising administering to a subject in need thereof an effective amount of at least one CB<SUB>x</SUB> modulator having K<SUB>ATP</SUB> channel modulating properties.

en

USE OF CBX CANNABINOID RECEPTOR MODULATORS AS POTASSIUM CHANNEL MODULATORS

12524183_DE,12524187_DE,12524186_DE,12524185_DE,6743883_DE,12708201_DE

12708201_DE,12524186_DE,12524187_DE,12524185_DE,12524183_DE

A61K 31/09,A61K 31/353,A61K 31/415,A61K 31/425,A61K 31/454,A61K 31/5415,A61K 31/542,A61P 3/00,A61P 3/04,A61P 3/06,A61P 3/10,A61P 9/00,A61P 9/06,A61P 9/10,A61P 9/12,A61P 11/06,A61P 13/00,A61P 13/10,A61P 15/00,A61P 15/10,A61P 17/00,A61P 17/14,A61P 19/06,A61P 25/00,A61P 25/04,A61P 25/08,A61P 25/28,A61P 35/00,A61P 43/00

1994-09-09

Y

An improved error control coding scheme is implemented in low bit rate coders in order to improve their performance in the presence of transmission errors typical of the digital cellular channel. The error control coding scheme exploits the nonlinear block codes (NBCs) for purposes of tailoring those codes to a fading channel in order to provide superior error protection to the compressed half rate speech data. For a half rate speech codec assumed to have a frame size of 40 ms, the speech encoder puts out a fixed number of bits per 40 ms. These bits are divided into three distinct classes, referred to as Class 1, Class 2 and Class 3 bits. A subset of the Class 1 bits are further protected by a CRC for error detection purposes. The Class 1 bits and the CRC bits are encoded by a rate 1/2 Nordstrom Robinson code with codeword length of 16. The Class 2 bits are encoded by a punctured version of the Nordstrom Robinson code. It has an effective rate of 8/14 with a codeword length 14. The Class 3 bits are left unprotected. The coded Class 1 plus CRC bits, coded Class 2 bits, and the Class 3 bits are mixed in an interleaving array of size 16x17 and interleaved over two slots in a manner that optimally divides each codeword between the two slots. At the receiver the coded Class 1 plus CRC bits, coded Class 2 bits, and Class 3 bits are extracted after de-interleaving. Maximum likelihood techniques using soft decision are employed to decode the Class 1 plus CRC bits as well as the Class 2 bits. The CRC is also used to further reduce the bit error rate (BER) of the subset of Class 1 bits over which it was applied by using generalized decoding techniques. In addition to the CRC based bad frame indication flag, raw channel bit error rate estimates for each codeword are also sent to the decoder as well. <IMAGE>

en

High performance error control coding in channel encoders and decoders

12606_US

3378541_US,3378540_US,3378539_US,3277004_US

H03M 13/09,H03M 13/21,H03M 13/27,H03M 13/29,H03M 13/2903,H03M 13/2927,H03M 13/35,H04L 1/0054,H04L 1/0065,H04L 1/007,H04L 1/201,H04L 1/208

2004-09-21

N

An original composite eye diagram is reformulated by deliberately re-alignin g its component eye diagrams according to some appropriate standard. This 'forced-alignment' shifts the components in one or both of the time and voltage ayes. Notice is taken of the shift(s) fo r each channel, and that shift data is appended to the data structures for the original components. The content of the data structure can be read in its original form, or, read and force-aligned. A force-aligned composite eye diagram created from the re-aligned components can then be displayed, investigated and evaluated with any of the existing tools that are used to analyze eye diagrams, simply by instructing the process that reads a component eye diagram data structure to reform that component as it is being read. Automatic forced-alignment of the component eye diagrams involves two steps. First, fo r each component eye diagram some specified property an 'earmark' having a (time, voltage) value is measured. Individual earmarks may be the centroid of an eye opening for each channel in the group, or representative point of transition. Second, each component is offset in time, voltage, or both, according to the difference between its earmark and some forced-alignment reference that is associated with the enti re group of channels.That forced-alignment reference may be the earmark of a selected component eye diagram or an average of all of the earmarks in the group. Manual shifting of each component eye diagram by the operator is also possible. The forced-alignment shift data is appended to the eye diagram dat a structures. Patterns in the forced-alignment data can be discovered by inspection of a report showing th e amounts of forced-alignment shifting. Channels in the report can be sorted according to their degree of alignment.

en

FORCED-ALIGNMENT MEASUREMENT TOOLS FOR COMPOSITE EYE DIAGRAMS

16687085_US

16710500_US

G01R 13/029,H04L 1/24

1998-01-09

Y

A method for improving the associating articles of information or stories with topics associated with specific subjects (subject topics) and with a general topic of words that are not associated with any subject. The inventive method is trained using Hidden Markov Models (HMM) to represent each story with each state in the HMM representing each topic. A standard Expectation and Maximization algorithm, as are known in this art field can be used to maximize the expected likelihood to the method relating the words associated with each topic to that topic. In the method, the probability that each word in a story is related to a subject topic is determined and evaluated, and the subject topics with the lowest probability are discarded. The remaining subject topics are evaluated and a sub-set of subject topics with the highest probabilities over all the words in a story are considered to be the 'correct' subject topic set. The method utilizes only the positive information and words related to other topics are not taken as negative evidence for a topic being evaluated. The technique has particular application to text that is derived from speech via a speech recognizer or any other techniques that results in a text file. The use of a general topic category enhances the results since most words in any story are not keywords that are associated with any given subject topic. The removal of the general words reduces the numbers of words being considered as keywords related to any given subject topic. The reduced number of words being processed allows the method to enhance the discrimination between the fewer words as related to the subject topics. The topics can range from general, for example 'the U.S. economy', to very specific, for example, 'the relationship of the yen to the dollar in the U.S. economy.'

en

Topic indexing method

5298395_US

5298396_JP,5298397_US

G06F 40/211,G06F 40/279,G10L 15/183,Y10S 707/99936

2008-05-08

N

There is provided a dictionary registration system which makes it possible to register a word into a user dictionary while minimizing an adverse effect that the word may have on natural language processing, if any. The dictionary registration system performs natural language processing by using a user dictionary, and includes a data processing apparatus that performs the natural language processing by managing and using the user dictionary and a storage apparatus that retains system dictionary information and user dictionary information for use in the natural language processing. The storage apparatus includes the system dictionary information for use in the natural language processing, and the user dictionary. The data processing apparatus includes: a word information registering init that registers information on an input word into the user dictionary; a difference creating unit that creates differences in a result of processing between a first result of processing when the natural language processing is performed, by using the system dictionary, information and a second result of processing when the natural language processing is performed by using the system dictionary information and the user dictionary information; a correct-incorrect accepting unit that accepts correct-incorrect judgments as to whether changes from the first result of processing to the second result of processing are correct or incorrect, the changes corresponding to the differences created by the difference creating unit; and dictionary registration unit that registers registration information on the accepted word into the user dictionary along with part or all of pairs of the correct-incorrect judgments accepted and input sentences from which the differences given the respective correct-incorrect judgments are created.

en

DICTIONARY REGISTERING SYSTEM, DICTIONARY REGISTERING METHOD, AND DICTIONARY REGISTERING PROGRAM

7458803_JP,10867938_JP,5217703_JP

10867938_JP,7458803_JP

G06F 40/242

2018-03-16

N

Hearing difficulties are the most commonly reported disabilities among Veterans. Blast exposures during explosive events likely play a role, given their propensity to directly damage both peripheral auditory system (PAS) and central auditory system (CAS) components. Post-blast PAS pathophysiology has been well-documented in both clinical case reports and laboratory investigations. In contrast, blast-induced CAS dysfunction remains under-studied, but has been hypothesized to contribute to an array of common Veteran behavioral complaints including learning, memory, communication, and emotional regulation. This investigation compared the effects of acute blast and non-blast acoustic impulse trauma in adult male Sprague-Dawley rats. An array of audiometric tests were utilized, including distortion product otoacoustic emissions (DPOAE), auditory brainstem responses (ABR), middle latency responses (MLR), and envelope following responses (EFR). Generally, more severe and persistent post-injury central auditory processing (CAP) deficits were observed in blast-exposed animals throughout the auditory neuraxis, spanning from the cochlea to the cortex. DPOAE and ABR results captured cochlear and auditory nerve/brainstem deficits, respectively. EFRs demonstrated temporal processing impairments suggestive of functional damage to regions in the auditory brainstem and the inferior colliculus. MLRs captured thalamocortical transmission and cortical activation impairments. Taken together, the results suggest blast-induced CAS dysfunction may play a complementary pathophysiologic role to maladaptive neuroplasticity of PAS origin. Even mild blasts can produce lasting hearing impairments that can be assessed with non-invasive electrophysiology, allowing these measurements to serve as simple, effective diagnostics.

en

CHANGES IN AUDITORY EVOKED RESPONSES AS SIMPLE, RAPID BIOMARKERS FOR BLAST INJURY AND OTHER TRAUMATIC BRAIN INJURIES

5210860_US

57994476_US,58065025_US,58067863_US,6362225_US

A61B 5/125,A61B 5/374,A61B 5/38,A61B 5/4064,A61B 5/7257,A61B 5/7278

2021-09-08

N

The present disclosure provides a vehicle control device that enables a driver to utilize an ADAS more effectively. A vehicle control device 10 is mounted in a vehicle and is connected to an information processing device 20 external to the vehicle, in such a way that information can be communicated. The vehicle is provided with: an external environment sensor 1 for sensing external environment information around the vehicle; a vehicle sensor 2 for sensing vehicle information relating to the traveling state of the vehicle; a position sensor 3 for sensing position information of the vehicle; and an ADAS actuator 7 for carrying out driving assistance of the vehicle. The vehicle control device 10 includes a proficiency level processing unit 12, an assistance difficulty calculating unit 13, a travel history processing unit 14, and an advice content determining unit 15. The proficiency level processing unit 12 calculates a driving tendency and a proficiency level for the driver of the vehicle on the basis of the external environment information and the vehicle information. The assistance difficulty calculating unit 13 calculates an assistance difficulty on the basis of the driving tendency and the vehicle information. The travel history processing unit 14 acquires, from the information processing device 20, the proficiency level, a driving assistance intervention frequency, a driving assistance usage rate, and a behavior variation, for the drivers of a plurality of vehicles. The advice content determining unit 15 calculates an assistance utilization degree on the basis of the assistance difficulty, the driving assistance usage rate, the behavior variation, and the intervention frequency, and causes advice content based on the assistance difficulty and the assistance utilization degree to be uttered.

en

VEHICLE CONTROL DEVICE, INFORMATION PROCESSING DEVICE, AND VEHICLE CONTROL SYSTEM PRODUCTION METHOD

64042531_JP

85339828_JP

B60W 40/02,B60W 50/14,G08G 1/00,G08G 1/16

1997-09-30

Y

Cytosolic extracts from a human lymphoblastoid B cell line, RPMI 8392, established from a patient with acute lymphocytic leukemia, contain two major forms of cyclic nucleotide phosphodiesterase (PDE): Ca2+-calmodulin dependent PDE (PDE1) and cAMP specific PDE4 subtypes. In contrast, normal quiescent human peripheral blood lymphocytes (HPBL) are devoid of PDE1 activity. Using reverse transcription-polymerase chain reaction (RT-PCR), the mRNA encoding the 63 kDa form of PDE1 (PDE1B1) is expressed in RPMI 8392 cells, but not in normal, resting HPBL. This mRNA is, however, induced in HPBL following mitogenic stimulation by phytohemagglutinin (PHA). Also using RT-PCR, the full open reading frame for human PDE1B1 cDNA was cloned from RPMI 8392 cells and it encodes a protein of 536 amino acids with 96% identity to bovine, rat and mouse species. RT-PCR also identifies the presence of PDE1B1 in other human lymphoblastoid and leukemic cell lines. The PHA induced increase in PDE1B1, PDE4A and PDE4D mRNA is mimicked by incubation of HPBL with dibutyryl cAMP (dbcAMP) and 1-methyl-3-isobutylxanthine (IBMX). Inhibition of PDE1 or PDE4 activity by selective inhibitors induced RPMI 8392 cells, as well as the other cell lines, to undergo apoptosis. Culture of RPMI 8392 cells with an 18 nucleotide phosphorothioate antisense oligodeoxynucleotide, targeted against the translation initiation region of the RPMI 8392 mRNA, led to a specific reduction in the amount of PDE1B1 mRNA after 1 day, and its disappearance after 2 days, and induced apoptosis in these cells in a sequence specific manner. This suggests that PDEs, particularly PDE1B1 and some of the subtypes of PDE4, may be useful therapeutic targets for inducing the death of leukemic cells and for treatment of immoproliferative disorders and immune dysfunction.

en

Antisense oligodeoxynucleotide against phosphodiesterase

10575040_US

10575041_US

A61K 38/00,C12N 9/16,C12N 15/1137,C12N2310/315,C12Q 1/68,C12Q 1/6886,C12Q2600/158

2019-11-25

N

The present disclosure provides a fast approximate as well as exact hierarchical network storage and retrieval system and method for encoding and indexing graphs or networks as well as for identifying substructure matches or analogs within graph data. Cognitive Memory encodes graphs via generalized combinatorial maps and a new quantum inspired Q-Hashing algorithm to summarize local structures of the graph along with a contraction and graph property calculation to build an index data structure called the Cognitive Signature for property based, analog based or structure or sub-structure based search. The system and method of the present invention is ideally suited to store and index all or parts or substructures or analogs of graphs as well as dynamically changing graphs such as traffic graphs or flows and motion picture sequences of graphs. The system and method has the advantage that properties of the Cognitive Signature of the graph can be used in correlations to the properties of the underlying data making the system ideal for semantic indexing of massive scale graph data sets. WO 2016/154460 PCT/US2016/024060 nt-- 0 COGNITIVE SIGNATURE: GUID = gmaplT= as~ss- ((0.5823)0,(0.5981i),(0.6773)2,(0.7659)3,(0.8115)4,(0.8921)5, (0.8921)6) u t G ((0.1001)o, (0.1501)1, (0.2533)2, (0.3738)3, (0.6738)4, (0.9738), u )i (0.9738)6))F=(1,1, 1, 1,1, 1,00,0, 0, 1, 1, 1)S= A s [ab,c,d,e,f,m,n,o,p,q,r,s,t,u; ( 'D DUNRC = 4895928170784910768550999108 DCNRC = 316855913034227244594501010500 DATA Q-MEDOIDS COMPILE INTO NETWORK BLOOMFILTER COGNITIVE INDEX SIGNATURE RANKED COMPARE TO MATCHES AND COGNITIVE SIGNATURES IN NO MATCH ANALOGS COGNITIVE MEMORY COGNITIVE MEMORY-LEVE K (RDBMS TABLES AND MVP-REE) COGNITIVE MEMORY-LEVEL-K-1 (RDBMS TABLES AND MVP-TREE` COGNITIVE MEMORY-L-EVEL-1 (GMAP, RDBMS TABLES AND MVP-TREE)

en

HUMAN-AIDED GEO-RECTIFICATION OF GEOSPATIAL METADATA IN VIDEO USING A GRAPHICAL INTERFACE

5986734_US

79918749_,79839872_,79777750_,16126624_

G01C 21/32,G01C 21/3673,G06V 20/17,G06V 20/176,G06V 20/182,G06V 20/20

2019-11-25

N

The present disclosure provides a fast approximate as well as exact hierarchical network storage and retrieval system and method for encoding and indexing graphs or networks as well as for identifying substructure matches or analogs within graph data. Cognitive Memory encodes graphs via generalized combinatorial maps and a new quantum inspired Q-Hashing algorithm to summarize local structures of the graph along with a contraction and graph property calculation to build an index data structure called the Cognitive Signature for property based, analog based or structure or sub-structure based search. The system and method of the present invention is ideally suited to store and index all or parts or substructures or analogs of graphs as well as dynamically changing graphs such as traffic graphs or flows and motion picture sequences of graphs. The system and method has the advantage that properties of the Cognitive Signature of the graph can be used in correlations to the properties of the underlying data making the system ideal for semantic indexing of massive scale graph data sets. WO 2016/154460 PCT/US2016/024060 nt-- 0 COGNITIVE SIGNATURE: GUID = gmaplT= as~ss- ((0.5823)0,(0.5981i),(0.6773)2,(0.7659)3,(0.8115)4,(0.8921)5, (0.8921)6) u t G ((0.1001)o, (0.1501)1, (0.2533)2, (0.3738)3, (0.6738)4, (0.9738), u )i (0.9738)6))F=(1,1, 1, 1,1, 1,00,0, 0, 1, 1, 1)S= A s [ab,c,d,e,f,m,n,o,p,q,r,s,t,u; ( 'D DUNRC = 4895928170784910768550999108 DCNRC = 316855913034227244594501010500 DATA Q-MEDOIDS COMPILE INTO NETWORK BLOOMFILTER COGNITIVE INDEX SIGNATURE RANKED COMPARE TO MATCHES AND COGNITIVE SIGNATURES IN NO MATCH ANALOGS COGNITIVE MEMORY COGNITIVE MEMORY-LEVE K (RDBMS TABLES AND MVP-REE) COGNITIVE MEMORY-LEVEL-K-1 (RDBMS TABLES AND MVP-TREE` COGNITIVE MEMORY-L-EVEL-1 (GMAP, RDBMS TABLES AND MVP-TREE)

en

COGNITIVE MEMORY GRAPH INDEXING, STORAGE AND RETRIEVAL

53276498_US

55255081_

G06F 16/2228,G06F 16/28,G06F 16/9024,G06N 10/00

1998-10-05

N

A 3-substituted tetrahydropyridopyrimidione derivative of the formula shown as a therapeutic composition having a high affinity for 5-HT1B, 5-HT1D and 5-HT1A serotonin receptors. The compounds are suitable for treating pathological states in which the serotonin concentration is reduced such as depression, mood disturbances with central nervous causation (dysthymia), anxiety such as panic attacks, sociophobia, obsessive-compulsive neuroses and post-traumatic stress symptoms, memory disturbances such as dementia, amnesias and age-related loss of memory and psychogenic eating disorders such as anorexia nervosa and bulimia nervosa. Wherein; one of the two radicals X and Y is CH2 and the other is NR1, R1 is hydrogen, C1-6alkyl branched or unbranched, CO-C1-4alkyl, CO2tBu, CO-phenyl and a phenylalkyl-C1-4 radical which in turn may be substituted on the aromatic system by F, Cl, Br, I, C1-4alkyl, C1-4alkoxy, trifluoromethyl, hydroxyl, amino, cyano or nitro, A is branched or unbranched C1-10alkylene or straight-chain or branched C2-10alkylene which comprises at least one group Z which is selected from O, S, NR2, cyclopropyl, CO2, CHOH, a double or triple bond, R2 is hydrogen and C1-4alkyl, B is 4-piperidine, 4-tetrahydro-1,2,3,6 pyridine, 4-piperazine or the corresponding cyclic compounds enlarged by one methylene group, with the linkage to A being via an N atom of B, and Ar is phenyl which is unsubstituted or substituted by C1-6alkyl branched or unbranched, O-C1-6alkyl branched or unbranched, OH, F, Cl, Br, I, trifluoromethyl, NR22, CO2R2, cyano or phenyl, or is tetralin, indan, naphthalene which is unsubstituted or substituted by C1-4alkyl or O-C1-4alkyl, anthracene or 5- or 6-membered aromatic heterocycles having 1 or 2 heteroatoms which are selected, independently of one another, from O and N.

en

Serotonin antagonists 3-substituted tetrahydropyridopyrimidinone derivatives for treating 5HT, depression and related disorders

6671312_

33969116_,33951017_,33967955_,33951019_,33947631_,25396300_,33968014_,15019356_,13222683_

A61P 1/00,A61P 1/14,A61P 3/04,A61P 5/00,A61P 9/12,A61P 15/00,A61P 25/00,A61P 25/22,A61P 25/24,A61P 25/28,A61P 43/00,C07D 471/04

2016-06-20

N

The claimed invention relates to a system for human motor function recovery created based on a robotic kinetic trainer containing a whole-body controlled exoskeleton, as well as to a method of human motor function recovery based on adaptive kinesitherapy techniques. A system for human motor function recovery is offered, implemented as a robotic kinetic trainer with a whole-body exoskeleton, formed by a controlled movable frame, consisting of kinematically interconnected orthopaedic modules with a suspension system that correspond to body parts, actuated by the drives subsystem, and an outer rigid fixed frame, kinematically connected to the controlled movable frame and forming a two-layer exoskeleton together with it. Electromechanical drives subsystem, where each of the drives is connected to the corresponding orthopaedic module by flexible communication, is located on the outer fixed frame. Orthopaedic modules and human body physiological indicators sensors are connected to the control software and hardware for spatial position change of each orthopaedic module via the outer fixed frame. The hardware and software are also equipped with a virtual reality imaging subsystem configured to co-operate with the electromechanical drives subsystem. The two-layer exoskeleton is equipped with the initial suspension position fixation device with support in the hip area and/or in the upper body area. A method of human motor function recovery is also offered, where the recovery of the system described above is carried out in two stages, where at the first stage, stable motion pattern matrices are created or restored in the central nervous system, and at the second stage, the connections between the surrounding events and the recovered motion pattern matrices are restored as responses to these events.

en

SYSTEM AND METHOD FOR RESTORING HUMAN MOTOR ACTIVITY

57746053_RU

57699642_BY,57700857_BY

A61F 4/00,A61H 1/00,A61H 1/0262,A61H2001/0211,A63B 23/00,A63B 23/0405,A63B 24/00,A63B 24/0003,A63B 24/0062,A63B 24/0075,G16H 20/30,G16H 20/40

2000-09-08

Y

A system and method responsive to input stimuli is provided by incorporating a computer software program, hardware processing engine, or a specialized ASIC chip processor apparatus to capture concurrent inputs that are responsive to training stimulation, store a model representing a synthesis of the captured inputs, and use the stored model to generate outputs in response to real-world stimulation. Human user forced-choice approval/disapproval generated descriptions and decisions may be dynamically mapped with conventionally presented information and sensor and control data. The model mapping is stored into and out of a conventional mass storage device, such as is used in a relational database for use in generating a response to the stimuli. By accessing commonly stored mappings, the system can be incorporated into a mixture of multiple domains and disciplines of users and can create a common understanding of knowledge and design concept contained within it through mutual interaction, and subsequent automatic modifications to a common relational database. The system and method is applicable to conventional storage and presentation devices, making it easily incorporated into a variety of commercial products, utilizing current commercial human-machine interfaces (e.g. Human-Machine Interface graphical user interface, or Graphical User Interface) and current mass storage devices. The system uses N-dimensional descriptions of observations and concepts in an infinitely expandable space, embracing elements of human thought. This allows the user to tailor this system to control operation of automated devices and appliances to reflect the individual's wishes and desires as a dynamic representation and mapping of user descriptions and decisions with information, sensor data, and device controls.

en

System and method for dynamic knowledge construction

9375425_US

9375426_US

G06K 9/6232,G06N 3/02,G06V 10/7715

2019-01-24

N

The present disclosure provides a method for, in order to achieve a predetermined goal, determining a goal achievement prediction probability at a particular time point in process of a conversation session between one user terminal among multiple user terminals and a conversation understanding AI service server on a conversation understanding AI service server configured to process a natural language conversation for each of the multiple user terminals. A method according to the present disclosure comprises the steps of: receiving a natural language input from a user terminal at a particular time point; determining an intent corresponding to the received natural language input; determining a conversation history at the particular time point, wherein the conversation history indicates a flow of intents between the user terminal and a conversation understanding AI service server generated to the particular time point in a conversation session and includes an intent determined at the end of the flow of the intents; determining at least one conversation pattern including the conversation history among conversation patterns on the basis of the conversation history and a template prepared in advance for the conversation understanding AI service server, wherein the template includes multiple conversation patterns, each of which represents a flow of corresponding intents, and each conversation pattern has the number of times of goal achievement success and the number of times of goal achievement failure; and determining a goal achievement prediction probability at the particular time point on the basis of the corresponding number of times of the goal achievement success and the corresponding number of times of the goal achievement failure of the determined at least one conversation pattern.

en

METHOD FOR DETERMINING OPTIMAL CONVERSATION PATTERN FOR GOAL ACHIEVEMENT AT PARTICULAR TIME POINT DURING CONVERSATION SESSION ASSOCIATED WITH CONVERSATION UNDERSTANDING AI SERVICE SYSTEM, METHOD FOR DETERMINING GOAL ACHIEVEMENT PREDICTION PROBABILITY, AND COMPUTER-READABLE RECORDING MEDIUM

71917131_KR

71944318_KR,65188703_KR

G06F 40/35,G10L 15/06,G10L 15/18,G10L 15/1822,G10L 15/22,G10L 15/30

2019-12-20

N

A three-dimensional display module based on light-emergent-limiting pixel block-aperture pairs (10, 10', 10', 10'', 10''). The three-dimensional display module comprises more than one light-emergent-limiting pixel block-aperture pair (10, 10', 10', 10'', 10''). By combining the divergence angle constraint and vector guidance of a projected light beam from each pixel of pixel blocks (11, 11', 11', 11'', 11'') in each light-emergent-limiting pixel block-aperture pair (10, 10', 10', 10'', 10'') with the isolation, regarding optical crosstalk, by a spatial gap between adjacent pixel block-aperture pairs (10, 10', 10', 10'', 10''), projected light of the pixel blocks (11, 11', 11', 11'', 11'') of each light-emergent-limiting pixel block-aperture pair (10, 10', 10', 10'', 10'') is only emergent and transmitted by means of apertures (12, 12', 12', 12'', 12'') of the pixel block-aperture pairs (10, 10', 10', 10'', 10''). On the basis of the technological path of a Maxwellian view and/or the technological path of monocular multiple views, the focusing-convergence conflict is overcome. The spatial arrangement multiplexing of a plurality of light-emergent-limiting pixel block-aperture pairs (10, 10', 10', 10'', 10'') solves the problem of a limited aperture dimension of a near-to-eye three-dimensional display module limiting a viewing angle; and the vector guidance of the projected light of the light-emergent-limiting pixel block-aperture pairs (10, 10', 10', 10'', 10'') and the spatial isolation between the light-emergent-limiting pixel block-aperture pairs (10, 10', 10', 10'', 10'') solve the problem of crosstalk between displayed information of the display module, and the combination of the two makes the display module have the display characteristics of a large viewing angle and low noise.

en

THREE-DIMENSIONAL DISPLAY MODULE BASED ON LIGHT-EMERGENT-LIMITING PIXEL BLOCK-APERTURE PAIR

63752135_CN

67873909_CN,63773215_CN

G02B 27/01,G02B 30/30

2017-07-11

N

A method and system for transforming low-quality projection data into higher quality projection data, using of a machine learning model. Regions are extracted from an input projection image acquired, for example, at a reduced x-ray radiation dose (lower-dose), and pixel values in the region are entered into the machine learning model as input. The output of the machine learning model is a region that corresponds to the input region. The output information is arranged to form an output high-quality projection image. A reconstruction algorithm reconstructs high-quality tomographic images from the output high-quality projection images. The machine learning model is trained with matched pairs of projection images, namely, input lower-quality (lower-dose) projection images together with corresponding desired higher-quality (higher-dose) projection images. Through the training, the machine learning model learns to transform lower-quality (lower-dose) projection images to higher-quality (higher-dose) projection images. Once trained, the trained machine learning model does not require the higher-quality (higher-dose) projection images anymore. When a new lower-quality (low radiation dose) projection image is entered, the trained machine learning model would output a region similar to its desired region, in other words, it would output simulated high-quality (high-dose) projection images where noise and artifacts due to low radiation dose are substantially reduced, i.e., a higher image quality. The reconstruction algorithm reconstructs simulated high-quality (high-dose) tomographic images from the output high-quality (high-dose) projection images. With the simulated high-quality (high-dose) tomographic images, the detectability of lesions and clinically important findings can be improved.

en

TRANSFORMING PROJECTION DATA IN TOMOGRAPHY BY MEANS OF MACHINE LEARNING

50053097_US

50053097_US

A61B 6/03,A61B 6/032,A61B 6/5205,A61B 6/563,G06N 3/0454,G06N 3/084,G06N 5/003,G06N 7/005,G06N 20/00,G06N 20/10,G06N 20/20,G06T 3/4046,G06T 3/4053,G06T 7/11,G06T 11/008

1994-07-12

N

High output power, high gain, and low noise are achieved in a two-stage optical amplifier, suitable for use as a repeater for a long haul lightwave communication system, in accordance with the principles of the invention, by employing a first amplifying stage having a signal gain sufficiently small to prevent self-saturation by amplified stimulated emission (ASE) that uses counter-propagating pump light to cause maximum inversion of the first stage amplifying medium. In an illustrative embodiment of the invention, EDFAs are used in each of two amplifying stages. The length of the EDFA in the first stage is short enough to ensure nearly complete inversion of the EDFA from pump light that counter-propagates with the signal. The counter-propagating pump light allows the invention to advantageously avoid the significant noise figure penalty from the input loss associated with co-propagating pump light. And, noise figure is improved becausecomplete inversion is achieved throughout the EDFA, and, at the input where the noise figure is most sensitive to inversion. The short length also eliminates self-saturation of the EDFA from ASE which degrades the noise figure. However, the length, and hence the gain, of the EDFA in the first stage is long enough to provide sufficient gain so that the noise figure of the two-stage amplifier, as a whole, is determined primarily by that of the first stage. A second EDFA in the second stage of the amplifier may then be configured using co-propagating or counter-propagating pump light for additional signal amplification to provide the required output power and gain for long haul lightwave systems. Other aspects of illustrative embodiments of the invention include the use of passive optical elements including filters, isolators, and attenuators. (FIG. 1)

en

HIGH POWER, HIGH GAIN, LOW NOISE, TWO-STAGE OPTICAL AMPLIFIERS

5895256_US

16456054_US,16393262_US,16370928_US,16456053_US,16292391_US,16292392_US

H01S 3/0078,H01S 3/06758,H01S 3/094061,H01S 3/09408,H01S2301/02,H04B 10/29,H04B 10/291,H04B2210/003

1996-02-12

Y

Compsns. for oxidn. dyeing of keratinic fibres, esp. human hair, contain at least one developer; at least one 4-hydroxyindole coupler of formula (I); and at least one heterocyclic coupler selected from indoles of formula (II), benzimidazole derivs. of formula (III), benzomorpholines of formula (IV), pyridines of formula (V), 6-hydroxy-, 6-amino-, or 5,6-dihydroxy-indoline, quinoline derivs. of formula (VI), sesamol derivs. of formula (VII), and their acid-addn. salts. R1 = H or 1-4C alkyl; R2, R3 = H, 1-4C alkyl, COOH or 2-5C alkoxycarbonyl; X = H, halo, 1-4C alkyl, 1-18C alkoxy or acetylamino; R4, R5 = H or 1-4C alkyl; R6 = H, 1-4C alkyl or OH; Y = OH or NHR7; R7 = H, 1-4C alkyl or 1-4C hydroxyalkyl; provided that (a) when R6 = OH it is in the 6 position, Y = 5-OH and R4, R5 = H; (b) when Y = OH it is in position 6 or 7 and R6 is not OH; and (c) when Y = NH2 it is in position 4, 6 or 7; R8 = H or 1-4C alkyl; R9 = H, 1-4C alkyl or phenyl; R10 = OH, NH2 or OMe; R11 = H, OH, OMe or 1-4C alkyl; provided that (a) R10 is in the 4 position when it = NH2; (b) R11 is in the 7 position when R10 is in the 4 position; and (c) R11 is in the 6 position when R10 is in the 5 position; R12, R13 = H or 1-4C alkyl; Z = OH or NH2; R14 = H, OH, 1-4C alkoxy, 1-4C monohydroxyalkyl, 2-4C polyhydroxyalkyl, NH2 or OCH2CH2COCH2CH2OH; R15, R17 = H, OH, NH2 or 1-4C alkyl; but must be NH2 when R14 = polyhydroxyalkyl or OCH2CH2COCH2CH2OH; R16 = H or 1-4C alkyl; R18 = H, OH, 1-4C alkoxy, 1-4C monohydroxyalkyl, 2-4C polyhydroxyalkyl or NH2; provided that cpds. (V) do not contain more than two NH2 gps. or more than two OH gps. or more than one NH2 gp. and one OH gp., and that these NH2 and/or OH gps. must be meta to each other; R19 = OH or 1-4C alkoxy; R20 = H or NH2; R21 = OH or NH2; R22 = halo or 1-4C alkoxy.

en

Keratinous fibers oxidation dyeing composition comprising an oxidation base, an indolic coupler and an additional heterocyclic coupler and dyeing process

80_FR

469948_FR,469936_FR

A61K 8/492,A61Q 5/10

2020-09-28

N

The present invention provides a big data collection apparatus for artificial intelligence learning for face recognition, which can photograph a face image of a subject at various angles. The big data collection apparatus for artificial intelligence learning for face recognition to collect big data for artificial intelligence learning for face recognition using cameras having different identifications (IDs) comprises: a front camera installed on a middle portion to photograph a front portion of the face of a subject; a frame for vertical movement connected from an upper side to a lower side past the middle portion with respect to the middle portion, and having a shape in which the middle portion is bent towards the rear surface; upper and lower cameras connected to the frame for vertical movement to be moved on a first line connecting from the upper side to the lower side past the middle portion, and connected to be moved only up to a portion adjacent to the front camera to perform tilting photographing through a movement on the first line to photograph the face of the subject; a frame for left/right movement connected from a left side to a right side past the middle portion with respect to the middle portion, and having a shape in which the middle portion is bent towards the rear surface; and left and right cameras connected to the frame for left/right movement to be moved on a second line connecting from the left side to the right side past the middle portion, and connected to be moved only up to a portion adjacent to the front camera to perform panning photographing through a movement on the second line to photograph the face of the subject. The upper, lower, left, and right cameras photograph the face of the subject through movements at preset time intervals to collect data.

en

APPARATUS FOR COLLECTING A BIG DATA USING FACE-RECOGNITION FOR AN ARTIFICIAL INTELLIGENCE

80735076_KR

75805767_

G06N 20/00,G06V 40/161,H04N 5/2259,H04N 5/23299

1990-04-24

N

RAN 4008/347 The known compounds of the general formula I wherein A together with the two carbon atoms denoted by .alpha. and .beta. signifies the group (a) (b) or (c), R1 signifies halogen, cyano, lower alkyl. lower 1-alkenyl, lower alkoxymethyl or the group -COOR6 or -C?C-R7, R2 signifies hydrogen and R3 signifies lower alkyl or R2 and R3 together signify dimethylene or trimethylene, R4 and R5 each signify hydrogen, halogen, trifluoromethyl or lower alkyl, R6 signifies lower alkyl, C3-C7-cyclo-alkyl or C3-7-cycloalkyl-lower alkyl and R7 signifies hydrogen, lower alkyl, lower hydroxyalkyl. lower alkoxyalkyl, C3-7-cycloalkyl-lower alkyl, C3-7-cycloalkyl-lower hydroxyalkyl, C3-7-cyclo-alkyl-lower alkoxyalkyl, (C3-7-cycloalkyl-lower alkoxy)-lowec alkyl, (aryl-lower alkoxy)-lower alkyl, lower alkanoyloxy-lower alkyl, (C3-7-cycloalkyl- -lower alkanoyloxy)-lower alkyl, C3-7-cycloalkyl-carbonyloxy-lower alkyl, (aryl-lower alkanoyloxy) -lower alkyl, arylcarbonyloxy-lower alkyl, lower alkenyl, lower hydroxyalkenyl, lower alkoxy-lower alkenyl, (C3-7-cycloalkyl-lower alkoxy)-lower alkenyl, (aryl-lower alkoxy)-lower alkenyl, lower alkanoyloxy-lower alkenyl, (C3-7-cycloalkyl-lower alkanoyloxy)-lower alkenyl, C3-7-cycloalkylcarbonyl-oxy-lower alkenyl, (aryl-lower alkanoyloxy)-lower alkenyl, arylcarbonyloxy-lower alkenyl, C3-7-cyclo-alkyl, hydroxy-C4-7-cycloalkyl or lower alkoxy -C4-7-cycloalkyl, the compounds of formula I having the (S)- or (R,S)-configuration with respect to the carbon atom denoted by .gamma. when R2 and R3 together signify dimethylene or trimethylene, can be used in the treatment of neurological symptoms which are associated with circulatory disorders of the brain, especially in the treatment of neurological symptoms which are associated with cerebrovascular seizures.

en

IMIDAZODIAZEPINES FOR THE TREATMENT OF NEUROLOGICAL SYMPTOMS

16286738_CH

16286739_CH

A61K 31/55,A61P 25/00,A61P 25/28

1999-11-12

N

The present invention relates to a new and useful learning system. A computer-based system permits a user to create and manipulate basic elements within an environment. The system then represents relationships within the environment. The system and user cooperate to provide a learning opportunity for the user. As the user makes or reviews changes of basic elements, he or she can learn how different aspects of an element affect the overall interactions. Two specific embodiments are disclosed. In a first embodiment, the system is used for exploring geometric patterns. The basic elements are tiles which are formed and manipulated through operations of geometric symmetry. The tiles can be combined into different repeating patterns. Multiple tiles can be used within a pattern. Also, new tiles can be created from portions of the pattern. Thus through simple interactions using basic operations and simple parts, complex effects emerge. In other embodiments, the system is used for exploring sociodynamics. The basic elements are creatures with sets of defined behaviors. The system determines interactions between creatures or groups of creatures based upon a complete set of behaviors within the group. The user and the system can manipulate the behaviors, creatures, and interactions. Again, through simple interactions using basic operations and simple parts, complex effects emerge. Finally, a user interface is disclosed which can be used with the system of the present invention. The interface includes display areas for creation of basic elements, interactions between basic elements, and selectable elements or components of elements. The interface also includes a set of selectable functions for operating on specific basic elements or upon the interactions within the environment. <IMAGE>

en

System and methods for constructive-dialogic learning

40597_JP

3958213_US,3807723_US,3958212_US

G09B 5/02,G09B 5/065,G09B 7/04,G09B 23/04,G09B 23/06

2007-12-19

Y

Preparation of oxidation-reduction (redox) nano-medicine quantum dot room temperature superconductor quantum bit (qubit) networks includes processes of making unitary, binary, ternary, an d/or quaternary liquid pharmaceutical ingredients of an antioxidase antioxidant, a β-adrenergic receptor agonist, a P2-purinergic receptor agonist, and/or a phenylalkylamine calcium channel blocker in combination with either 1:20 xanthine oxidase (XO):xanthine (X) or X alone in a liquid phase by using the L16(2)15 and L9(3)4 orthogonal optimization design protocols and modulating spatial distance constraint from about 0.1 Å to about 200 Å as well as a 10 class clean bottom-up self-assembly approach. Redox nano-drug quantum dot superconductor qubit network can be identified at room temperature by Planck constant (ℏ︀)-related qubit metrology of electron spins and polaritons (the quantum state of photon-exciton hybrid or photoelectron coupling/co-tunneling) through conducting atomic force microscopy (C-AFM) and/or laser micro-photoluminescence (PL) spectrum standard measurement method, wherein ℏ︀-related quantum continuous variables (QCVs) are derived from faster Fourier transformation (FFT) of average current-voltage (I-V) curves and PL spectra, their first derivatives of relative phases in frequency and time domains (dr/df=ΔE/ℏ︀ and dr/dt=ΔE/ℏ︀) and their FFTs to acquire Σ(2n), Σ(2n·2n), Σ(2n+1), Σ(2n·2n), Σ(22n+1·22n+1) and/or Σ(22n+1) binary superconductor qubit matrix networks. Uses of this invention cover room temperature superconductor (resistance loss, insulator with conductor or ∞ conductance) quantum devices and quantum biology metrology, implanted nano-drug quantum dot diagnostic and therapeutic nanodevices and/or nano-bio-electrochemistry sensors with target-recognized functions.

en

Process of constructing oxidation-reduction nanomedicine quantum dots room temperature quantum bit networks

5330319_CN,5330320_CN

5330320_CN

A61K 41/0004

2004-05-13

N

The present invention provides a new sleep analysis technique with which sleep analysis with relatively high reliability can be simply and speedily performed by using sleeping depth data. An appearance ratio conversion processing portion reads sleeping depth data (qualitative variable) stored in a RAM to calculate a movement appearance ratio n-M.A.R. (quantitative variable) meeting a relation of sleeping depth=2 (deep sleep: SWS). Then, an evaluation result calculation processing portion reads the calculated movement appearance ratio data (quantitative variable) from the RAM, and processes the calculated movement appearance ratio data in accordance with an evaluation rule in an evaluation rule storage portion to calculate an evaluation score for the evaluation factor concerned. When the evaluation factor is 'rapidity of falling asleep' for example, a time period from a point when a person goes to bed to a point when the movement appearance ratio n-M.A.R. of the SWS rises is detected from the movement appearance ratio n-M.A.R. of the SWS. Then, an evaluation score corresponding to a length of a time period of the rising is acquired from a corresponding score table. According to the present invention, the sleeping depth data expressed as the qualitative variable is converted into the data related to the appearance ratio of the sleeping depth and expressed as the quantitative variable, and the evaluation factors are analyzed and evaluated using the data after the conversion. Thus, various evaluation factors such as 'rhythm of sleep', 'mental recovery', 'physical recovery' and 'rapidity of falling asleep' can be quantitatively evaluated. As a result, simplification for the processing can be realized and at the same time, highly reliable sleep analysis results can be provided.

en

Sleep analyzer and program product for giving sleep analysis function to computer

37169679_US

18088204_JP,19577049_JP,19577050_JP,19577048_JP

A61B 5/02055,A61B 5/0816,A61B 5/318,A61B 5/369,A61B 5/4812

1998-09-15

N

The present invention relates to a new and useful learning system. A computer-based system permits a user to create and manipulate basic elements within an environment. The system then represents relationships within the environment. The system and user cooperate to provide a learning opportunity for the user. As the user makes or reviews changes of basic elements, he or she can learn how different aspects of an element affect the overall interactions. Two specific embodiments are disclosed. In a first embodiment, the system is used for exploring geometric patterns. The basic elements are tiles which are formed and manipulated through operations of geometric symmetry. The tiles can be combined into different repeating patterns. Multiple tiles can be used within a pattern. Also, new tiles can be created from portions of the pattern. Thus through simple interactions using basic operations and simple parts, complex effects emerge. In a second embodiment, the system is used for exploring a sociodynamic system. The basic elements are creatures with sets of defined behaviors. The system determines interactions between creatures or groups of creatures based upon a complete set of behaviors within the group. The user and the system can manipulate the behaviors, creatures, and interactions. Again, through simple interactions using basic operations and simple parts, complex effects emerge. Finally, a user interface is disclosed which can be used with the system of present invention. The interface includes display areas for creation of basic elements, interactions between basic elements, and selectable elements or components of elements. The interface also includes a set of selectable functions for operating on specific basic elements or upon the interactions within the environment.

en

Systems and methods for constructive-dialogic learning

40597_JP

3807721_US,3807722_US,3807723_US

G09B 5/02,G09B 5/065,G09B 7/04

2006-05-18

N

In one embodiment, the invention relates to a method for generating several single-color images from a multicolor image of a sample or object defined by intensity pixels (I<SUB>a</SUB>(x,y), I<SUB>ß</SUB>(x,y), I<SUB>?</SUB>(x,y)) of at least two color channels (a, ß, ?) in order to identify properties of structures of the object or sample or/and identify inherent colors of the object or sample or colors added thereto by a coloring treatment. The single-color images are defined by intensity pixels of only one of the color channels, intensity pixels of several of the color channels having the same intensity ratio among the color channels for all intensity pixels, or intensity pixels of only one resulting color channel that corresponds to a defined combination of the color channels. The multicolor image at least for the intensity pixels of at least one group of intensity pixels is based on an overlay of overlay contributions that are assigned to different original colors, especially at least approximately additive intensity contributions or intensity percentages or/and at least approximately subtractive intensity contributions or intensity percentages. According to the invention, the single-color images represent overlay contributions allocated to different original colors and are generated based on hypothetical or predefined characteristic intensity ratios or characteristic intensity ratios obtained from a calibration or derived from the multicolor image, said characteristic intensity ratios representing ratios between at least two intensity contributions or intensity percentages which are assigned to another one of the color channels, respectively, and are associated with the same property or structure of the object or sample or the same color of the object or sample.

en

SEPARATION OF SPECTRALLY OVERLAID OR COLOR-OVERLAID IMAGE CONTRIBUTIONS IN A MULTICOLOR IMAGE, ESPECIALLY TRANSMISSION MICROSCOPIC MULTICOLOR IMAGES

25196345_DE,25196346_DE

25196346_DE

G01N 21/6458,G06T 7/90,H04N 9/64

1998-09-17

N

To develop a neural model of a dynamic system with a nonlinear stoichiometric behavior, the system behavior is modeled for a forecast as a time sequence of at least one influence value of the system. The influence value is formed as an additive combination from a deterministic start value (y asterisk ) of a recurrent neural network (NN) and a linear modeled system fault ( epsilon ). At an initial time point, the recurrent neural network is adapted with the fault model adaptation fault, as a difference between the measured influence value at the first time point and the system fault. In an Independent claim an assembly identifies a recurrent neural network (NN) for the prognosis of at least one influence value on the system. It can produce a fault model (L) of a system fault ( epsilon ) of the dynamic system. It can show an adaptation fault for an initial time point. It can adapt the recurrent neural network with the adaptation fault, at least by training the neural network with the system behavior. Preferred Features: The system fault ( epsilon ) is modeled with a Kalman filter, where a missing measurement value in the time sequence is modeled infinitely with a variance, and a measurement value in the time sequence is modeled with a zero variance. The operation uses the equations: and the measurement value equation: where epsilon t and delta t are the additive noises with Yt asterisk the response, Yt the influence value and Xt the system fault. The recurrent neural network (NN) is trained with the real time learning protocol for neural networks. The linear fault model (L) is adapted with forwards/backwards Kalman filter equations. The neural network (NN) is a multi-layer Perceptron, with a hidden layer of three neurons. The measured blood sugar value can be inserted.

en

Method and device for the neuronal modelling of a dynamic system with non-linear stochastic behavior

220_DE

3800756_DE,3808018_DE

G06N 3/049

2017-05-09

Y

A method and system are disclosed for improving a policy for a stochastic control problem, the stochastic control problem being characterized by a set of actions, a set of states, a reward structure as a function of states and actions, and a plurality of decision epochs, the method comprising using a sampling device obtaining data representative of sample configurations of a Boltzmann machine, obtaining initialization data and an initial policy for the stochastic control problem; assigning data representative of an initial weight and a bias of respectively each coupler and each node and the transverse field strength of the Boltzmann machine to the sampling device; until a stopping criterion is met generating a present-epoch state-action pair, amending data representative of none or at least one coupler and at least one bias, performing a sampling corresponding to the present-epoch state-action pair to obtain first sampling empirical means, obtaining an approximation of a value of a Q-function at the present-epoch state-action, obtaining a future-epoch state-action pair, wherein the state is obtained through a stochastic state process, and further wherein the obtaining of the actioncomprises performing a stochastic optimization test on the plurality of all state-action pairs comprising the future-epoch state and any possible action to thereby provide the action at the future-epoch and update the policy for the future-epoch state; amending data representative of none or at least one coupler and at least one bias, performing a sampling corresponding to the future-epoch state-action pair, obtaining an approximation of a value of the Q-function at the future-epoch state-action, updating each weight and each bias and providing the policy when the stopping criterion is met.

en

METHOD AND SYSTEM FOR IMPROVING POLICY FOR STOCHASTIC CONTROL PROBLEM

58116945_

62810779_,69531965_,62604766_

G06E 3/005,G06N 3/0445,G06N 3/0472,G06N 3/08,G06N 3/088,G06N 7/005,G06N 10/00,G06N 20/00

1986-02-05

N

A distributed sensor system including an optical source (100) having a short coherence length for optionally continuously monitoring each sensor in the system. In one preferred embodiment, an array of fiber-optic sensors (110) are organized in a ladder configuration, with the sensors positioned in spaced relation and defining the rungs of the ladder. Light transmitted through the sensors is multiplexed onto a return arm (114) of the ladder, with sensor spacing being such that interference between light from different sensors is prevented. The multiplexed signals are received by an optical fiber receiver (118, 120) which couples the multiplexed light with an interfering optical reference signal to produce a phase difference signal representing conditions influencing selected sensors. Embodiments are disclosed for use of either pulsed or continuous wave light sources In another preferred embodiment, the sensors comprise a plurality of Mach-Zehnder interferometers (404,406) connected in series configuration by a common optical fiber (402), which provides multiplexed output signals from the sensors to a plurality of Mach-Zehnder interferometers (418, 420) comprising receivers. The optical path length differences between the arms (409, 410, 411 and 412) of each of the sensors (404, 406) are selected to prevent interference between the multiplexed sensor output signals from various sensors. The optical path lengths through the sensors (404, 406) and receivers (418, 420) are structured so that each receiver (418, 420) produces a phase difference signal relating to conditions affecting light transmission through a specific sensor (404,406). A phase and amplitude modulation technique is disclosed for providing heterodyned output signals from the dristributed sensor system.

en

COHERENT DISTRIBUTED SENSOR AND METHOD USING SHORT COHERENCE LENGTH SOURCES

2229713_US

2346389_US,2565182_GB,2565187_US,2565186_US,2503990_US

G01D 5/35383,G01J 9/00

2004-12-18

N

The present invention provides a method for diagnosing, detecting and monitoring brain function, especially neurological diseases and disorders. This invention examines the output of a neurological monitoring device such as an electroencephalography (EEG) recording. The EEG recording is often taken while a person is engaged in a specific neurological task such as delayed recognition. This invention provides for two methods for the diagnosis, detection and brain monitoring based on the EEG recording. The first is the use of the person as their own baseline for comparison. The efficacy of a person's brain function is measured by comparing a portion of their EEG recording with a different portion. Each of these portions is taken from the same EEG recording of a single neurological task performance. The second method is the minimal use of monitoring device output, such as an EEG recording, in a manner congruent with the neurological task being performed by the person. For example, to test a person's delayed recognition memory; a person would first be required to perform a delayed recognition memory task. Then, the EEG recording for two electrodes, P3 and P4 would be examined for the first 150 milliseconds after recognition memory stimulus onset. Then the EEG recording for two other electrodes, T7FPp1 and T8Fp2 would be examined for the next 150 milliseconds. Since this choice of electrodes and times is congruent with the neurological task of delayed recognition, the data is highly relevant to the monitoring of the person's delayed recognition memory. This method, combined with using a person as their own baseline allows this invention to provide high accuracy in the detection, diagnosis and monitoring of brain function, especially neurological diseases and disorders.

en

Method for diagnosing, detecting, and monitoring brain function including neurological disease and disorders

37181511_

37181509_US

A61B 5/16,A61B 5/4088

2019-03-08

N

The present invention relates to an apparatus and a method for diagnosing a body malalignment syndrome by using a plantar pressure and physical movement information, which can time-synchronize physical movement information and a plantar pressure during natural walking, collect the time-synchronized physical movement information and plantar pressure, and then accurately detect characteristics of a walking motion through independent analysis and linkage analysis according to a walking process, so as to more accurately diagnose a malalignment syndrome. In the present invention, a plantar pressure, movement of a patient's upper and lower body, and movement of the patient's musculoskeletal system related to a pressure change in the patient's foot in a stage-specific process for walking can be linked and analyzed with reference to time on the basis of information obtained by measuring the patient's walking in real time through a plantar pressure sensor and a 3D sensor, and thus a malalignment syndrome can be diagnosed more accurately and quickly and according to quantitative criteria, so that a reliable and objective diagnosis can be achieved. Further, 3D information on movement of a human body according to measurement by the 3D sensor can be compensated on the basis of a plantar pressure change according to a walking stage and a walking stage-specific pattern, through the plantar pressure sensor despite use of the 3D sensor, measurement by which is limited, and thus the reliability of the quantitative size of information necessary to determine a malalignment syndrome can be improved so that equipment enabling a detailed diagnosis of a malalignment syndrome can be manufactured at relatively low cost and can be easily provided to a place where the equipment is needed.

en

APPARATUS AND METHOD FOR DIAGNOSING BODY MALALIGNMENT SYNDROME BY USING PLANTAR PRESSURE AND PHYSICAL MOVEMENT INFORMATION

68361959_KR

68361959_KR,68591005_KR,73934838_KR

A61B 5/1038,A61B 5/1123,A61B 5/4538,A61B2562/02

2002-07-25

N

The invention relates to the use of: (a) an isolated gene sequence that is down-regulated in the spinal cord of a mammal in response to mechanistically distinct first and second models of neuropath ic or central sensitization pain; (b) an isolated gene sequence comprising a nucleic acid sequence of any of Tables I to VI; (c) an isolated gene sequence having at least 80% sequence identity with a nucleic acid sequence of any of Tables I to VI; (d) an isolated nucleic acid sequence that is hybridizable to any of the gen e sequences according to (a), (b) or (c) under stringent hybridisation conditions; (e) a recombinant vector comprising a gene sequence or nucleic acid sequence according to any one of (a) to (d); (f) a host cell containing the vector according to (e); (g) a non-human animal having in its genome an introduced gene sequence or nucleic acid sequence or a removed or down-regulated gene sequence or nucleic acid sequence according to any one of (a) to (d); (h) an isolated polypeptide comprising an amino acid sequence at least 90% identical to an amino acid sequence encoded by a nucleotide sequence according to any one of (a) to (d), or a variant polypeptide thereof with sequential amino acid deletions from the C terminus and/or the N-terminus; (i) an isolated polypeptide encoded by anucleotide sequence according to any one of (a) to (d); or (j) an isolated antibody that binds specifically to a polypeptide according to (h) or (i); in the screening of compounds for the treatment of pain, or for the diagnosi s of pain. The invention also relates to the use of naturally occurring compounds such as peptide ligands of the expression products of the above gene sequences and their associated signal transduction pathways for use in the treatment of pain.</S DOAB>

en

IDENTIFICATION AND USE OF MOLECULES IMPLICATED IN PAIN

5355881_US

13071938_GB,16715133_GB,13004289_GB,16715134_GB

A01K2217/05,A01K2217/075,A61K 38/00,A61P 29/00,C07K 14/47,C07K 14/4702,C07K 14/705,C12N 9/00,C12N 9/12,C12N 9/16,C12N 9/6421,C12Q 1/6883,C12Q2600/158

2005-01-13

N

System and method for measurement of optical parameters and characterization of multiport optical devices constituted by process control systems, one or more sources of optical test signal (11) (tunable laser source), optical circuit including optical fiber and several other optical components arrange d so as to constitute an interferometric optical arrangement, optical connectors, optoeletronic interfaces, photodetectors, analogical electronic; circuits, digital electronic circuits for digital signal processing and electronic circuits for data acquisition, the test and reference optical signals traversing paths with any lengths, that can be identical or distinct , the optical signal traversing at least one of said paths of interferometer being phase- and/or frequency-modulated. The signals of both interferometer arms are summed at a same photodetector (26) that translates to the electric domain the heterodyning of the optic signals, which contain the information of the optical characteristics of the DUT (17) (device under test), the transfe r of the optical signals between the diverse ports of the DUT being described by means of the Optical 'S'-Parameters where each 'Sxy' parameter is represente d using the formalism of Jones (Jones matrix) and/or the formalism of Muller (Muller matrix) and where all the determinations of the optical characteristics of the DUT (17) (bandwidth, phase, time delay, chromatic dispersion, 2nd order chromatic dispersion, reflectance, reflection coefficient, transmittance of the port 'y' to the port 'x' and vice versa, transmission coefficient of the port 'y' to the port 'x' and vice versa, insertion loss, polarization dependent loss, polarization mode dispersion (DGD/PMD), 2nd order DGD, etc.) are based on said 'Sxy' parameters.

en

SYSTEM AND METHOD FOR MEASUREMENT OF OPTICAL PARAMETERS AND CHARACTERIZATION OF MULTIPORT OPTICAL DEVICES

16890121_BR

13512573_BR,15815293_BR,15815294_BR,15815295_BR

G01M 11/3136,G01M 11/331,G01M 11/333,G01M 11/335,G01M 11/337,G01M 11/338,G01M 11/39

1996-11-14

Y

In accordance with the present invention, a novel class of substituted aryl compounds (containing ether, ester, amide, ketone or thioether substitution) that promote the release of ligands involved in neurotransmission have been discovered. In a particular aspect, compounds of the present invention are capable of modulating acetylcholine receptors. The compounds of the present invention are capable of displacing one or more acetylcholine receptor ligands, e.g., <3>H-nicotine, from mammalian neuronal membrane binding sites. Invention compounds may act as agonists, partial agonists, antagonists or allosteric modulators of acetylcholine receptors. Therapeutic indications for compounds with activity at acetylcholine receptors include diseases of the central nervous system such as Alzheimer's disease and other diseases involving memory loss and/or dementia (including AIDS dementia); cognitive dysfunction (including disorders of attention, focus and concentration), disorders of extrapyramidal motor function such as Parkinson's disease, progressive supramuscular palsy, Huntington's disease, Gilles de la Tourette syndrome and tardive dyskinesia; mood and emotional disorders such as depression, anxiety and psychosis; substance abuse including withdrawal symptoms and substitution therapy; neurocrine disorders and dysregulation of food intake, including bulimia and anorexia; disorders or nociception and control of pain; autonomic disorders including dysfunction of gastrointestinal motility and function such as inflammatory bowel disease, irritable bowel syndrome, diarrhea, constipation, gastric acid secretion and ulcers; pheochromocytoma, cardiovascular dysfunction including hypertension and cardiac arrhythmias, as well as co-medication uses in surgical applications.

en

NOVEL SUBSTITUTED ARYL COMPOUNDS USEFUL AS MODULATORS OF ACETYLCHOLINE RECEPTORS

48506_US

3654776_US,949143_US

A61P 1/00,A61P 25/00,A61P 25/04,A61P 25/16,A61P 25/28,A61P 43/00,C07D 207/08,C07D 207/12,C07D 209/94,C07D 211/54

1981-12-18

Y

An optical test chart for testing binocular vision. The chart has three lines of text, with the middle line printed or marked in letters or characters which have no polarizing effect. The line above this middle line is marked in letters or characters which have the effect of polarizing light reflected from them, in a plane of polarization in one direction, while the line below the middle line is similarly marked with letters or characters having the effect of polarizing reflected light but with the plane of polarization in a different direction at a substantial angle, preferably a right angle, to the direction of polarization caused by the upper line. The person whose vision is being tested views the test chart through polarizing spectacles, the spectacle in front of one eye having a plane of polarization corresponding to that of the upper line of text on the chart, and the spectacle in front of the other eye having a plane of polarization corresponding to that of the lower line of the text. If the person being tested perceives all three lines of the text with equal contrast, he has normal binocular vision or reading ability. If he perceives a difference in contrast between the different lines on the chart, or if he is unable to read either the top or bottom line, his binocular reading ability is impaired, and the kind of impairment can be determined by determining what he is able to read. Preferably a series of such test charts with the text in letters of different size are mounted displaceably on a lectern or easel, so that the chart sheets may be selectively turned to test the subject with lettering of different size, to determine the minimum size which the subject can read, thus establishing his visual acuity as well as his binocular reading ability.

en

Optical test chart for testing binocular reading ability

5282985_DE

7600987_DE,7600986_DE

A61B 3/08

1997-02-07

N

Alterations in the cellular redox state play a critical role in cell signaling a nd cell activation, suggesting that administration of sulflhydryl-reactive agents h ave important modulatory effects on the inflammatory response. Intracellular thiol depletion attenuates the pulmonary inflammatory response following intratracheal administration of endotoxin (LPS), and this attenuation supersedes the reduction in antioxidant defenses associated with depletion of the endogenous antioxidant, glutathione (GSH). Sprague Dawley rats were administered diethylmaleate (DEM, 6 mmole/kg), a rapidly acting GSH-depleting agent, followed by intratracheal administration of LPS. Lung injury was assessed by measuring the transpulmonary flux of 125l albumin and expressed as a permeability index (Pl). Administration of DEM reduced lung GSH levels from 1310~114 to 185~48 nmoles/g. This was associated with a reduction in the Pl following LPS treatment (LPS: 0.22~0.03 vs LPS+DEM: 0.03~0.01). Bronchoalveolar lavage fluid PMN counts were markedly reduced in animals pretreated with DEM (LPS: 90.5~24x106 vs LPS+DEM: 1 .9~0.4x106). The reduction in lung neutrophil sequestration was not due to an effect on the neutrophil, as peripheral blood PMN isolated from DEM-treated anim als had equivalent chemotactic responses to fMLP, and normal upregulation of CD11b. DEM pretreatment mitigated LPS induced upregulation of lung lCAM-1 protein and mRNA expression as demonstrated by immunohistochemistry and Northern analysis, respectively. DEM attenuates LPS-induced lung injury by preventing lun g PMN sequestration. This effect appears to be mediated through abrogation of endothelial lCAM-1 upregulation in response to LPS. These data suggest that intracellular thiols modulate lCAM-1 expression.

en

ANTI-INFLAMMATORY AGENT

16524936_CA,16524937_CA

16524937_CA,16524936_CA

A61K 31/00

2003-10-31

N

The present invention relates to a signal processing method and system for correcting organ motion artifacts for cardiac and brain imaging. A plurality of sets of MRI measurement data indicative of at least an image of an object is received. Each set correspon ds to one row k x of a k -space matrix of at least a k -space matrix. For each set a k -space matri x of the at least a k - space matrix is determined for allocation thereto based on motion informatio n of the object occurring during acquisition of the plurality of sets of the MRI measurement data. In a following step a location within the allocated k -space matrix corresponding to a row of the k -space matrix allocated thereto is determined for each set. At least a k -space matrix is then generated by re- arranging the plurality of sets. Each of the at least a k -space matrix comprises the sets of the plurality of sets of the MRI measurement data allocated thereto. Inverse Fourier transforming of the plurality of k -space matrices provides at least a reconstructed image. Through careful selection of the phases of the cardiac and respiratory cycles and corresponding ranges MRI data acquisition periods are of the order of seconds or a few minutes. Furthermor e, integration of motion artifact free MRI images of different phases of organ motionusing the coherent k -space synthesis according to the invention allows provision of an animation showin g different phases of a cardiac or lung cycle. In an embodiment for correcting motion artifacts for brain imaging a motion vector describing translational and rotational motion of a patient's head is tracked during the MRI data acquisition process. The motion artifacts are then corrected based on coherent k space synthesis using the motion vector data.

en

METHOD AND DEVICE FOR CORRECTING ORGAN MOTION ARTIFACTS IN MRI SYSTEMS

16470967_CA

13045974_DE,16250117_CA,12975158_CA,16774324_DE,16250116_CA

G01R 33/56325,G01R 33/5673

2014-07-28

Y

FIELD: chemistry.SUBSTANCE: invention relates to the field of organic chemistry, namely to heterocyclic compounds of formula I or pharmaceutically acceptable acid addition salt thereof, wherein Ris phenyl substituted by one, two or three substituents selected from halogen, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen, cyano or S(O)-lower alkyl, or represents morpholinyl, dihydropyranyl, pyridinyl or piperidinyl, wherein pyridinyl and piperidinyl are substituted with halogen, or is C(O)O-lower alkyl, Ris hydrogen; Ris hydrogen, lower alkyl substituted by halogen, -(CH)-S(O)-lower alkyl, -(CH)-cycloalkyl, -(CH2)-lower alkoxy or -benzyl-S (O)-lower alkyl; Ris hydrogen or lower alkyl, n is 1 or 2. Invention also relates to specific derivatives of 1,7-naphthyridine-3-carboxamide, a pharmaceutical composition based on the disclosed compounds and their use..EFFECT: new derivatives of 1,7-naphthyridine-3-carboxamide, stimulating neurogenesis and useful in the treatment of schizophrenia, obsessive-compulsive personality disorder, depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retina degeneration, traumatic brain injury, spinal cord injuries, post-traumatic stress disorder, panic disorder, Parkinson's disease, dementia, Alzheimer's disease, cognitive impairment, chemotherapy-induced cognitive dysfunction, Down Syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, stroke, disturbances due to radiation therapy, chronic stress, optic neuropathy or macular degeneration, abuse of neuro-active drugs, selected from alcohol, opiates, methamphetamine, phencyclidine and cocaine.11 cl, 1 tbl, 28 ex

en

1,7-NAPHTHRIDINE-3-CARBOXAMIDE DERIVATIVES, USEFUL AS NEUROGENISIS AGENTS

64403040_CH

67938850_DE,67792330_DE,69648053_DE,66842984_DE,67169751_CH

A61K 31/4375,A61K 31/4427,A61K 31/5377,A61P 9/10,A61P 21/02,A61P 25/00,A61P 25/08,A61P 25/14,A61P 25/16,A61P 25/18,A61P 25/22,A61P 25/24,A61P 25/28,A61P 25/32,A61P 25/36,A61P 27/02,A61P 27/16,C07D 401/04,C07D 471/04,C07D 498/04

2004-04-26

Y

A device and method for decoding neuronal responses wherein sequences of potentials from neurons are monitored while specific motor tasks are carried out, and these sequences are characterized using order statistics and subsequently the order statistics are used to decode action potentials representing unidentified motor tasks to determine the desired motor task. The method of the invention comprises the steps of monitoring action potentials caused by a motor task being requested by the brain, calculating a spike density function and order tasks for each distinct motor task, to relate action potentials to their specific motor task. The invention also offers methods of formulating instructions for a prosthetic device. This method comprises the steps of learning the neuronal responses of distinct motor tasks by monitoring action potentials caused by a motor task being requested by the brain, calculating a cumulative density function for each distinct motor task, and using order statistics to relate action potentials to their respective motor tasks; monitoring action potentials from at least one neuron of said user wherein the action potentials are caused by the request for an unknown motor task; using said learned neuronal responses to determine which motor task is being requested by the monitored neuron; and formulating instructions on how to carry out the requested motor task. The device of the invention comprises a prosthetic limb, a device capable of making said prosthetic limb carry out motor tasks, a device capable of recording action potentials from neurons, and a device containing instructions for monitoring neurons, calculating cumulative density functions, utilizing order statistics, and determining instructions for various motor tasks.

en

Decoding algorithm for neuronal responses

5223030_US

7137001_US,7137002_US

A61F 2/72

2015-10-30

Y

A magnetic resonance imaging protocol includes an acquisition segment to control an acquisition sequence to acquire magnetic resonance signals at a lower main magnetic field strength. A reconstruction segment controls reconstruction of a diagnostic magnetic resonance image from the magnetic resonance signals at a lower main magnetic field strength. A segmentation segment to control segmentation of a pre-determined image- detail of the diagnostic magnetic resonance image. In the magnetic resonance imaging protocol: the acquisition sequence has a set of imaging parameters that cause the image quality of the diagnostic magnetic resonance to be similar to the image quality of the magnetic resonance training images. The segmentation segment comprises: an initialisation portion which controls (i) access to a set of magnetic resonance training images acquired at main magnetic field of a higher main magnetic field strength (ii)registration of the diagnostic magnetic resonance image to one or more of the magnetic resonance training images and (iii) a segmentation proper applied to the diagnostic image to segment the pre-determined detail from the registered diagnostic magnetic resonance image. The one or more magnetic resonance training images includes an image detail corresponding to the pre-determined image detail in the diagnostic magnetic resonance image. Notably, the magnetic resonance training magnetic resonance images are acquired at a high magnetic field strength at 7T and its level of detail facilitates the accurate segmentation of notably the hippocampus from diagnostic magnetic resonance images at lower field strength of 3T. The diagnostic magnetic resonance images are acquired such that they resemble the training magnetic resonance images.

en

Magnetic resonance imaging protocol for segmentation of an image detail

18087805_NL

56398945_NL,42554587_NL,56546311_NL

A61B 5/055,G01R 33/445,G01R 33/54,G01R 33/56,G01R 33/5608,G01R 33/561,G01R 33/5611,G01R 33/5617

2000-10-03

N

A system and a method for reverse link power control in a wireless communications network generates power adjust commands for mobiles being served by a network base station in a centralized manner by considering overall system performance when an increased interference condition is detected. In one implementation, a base station power control processor adopts a modified reverse inner loop power control (RILPC) and/or a reverse outer loop power control (ROLPC) algorithm when an increased interference condition is detected. According to the modified RILPC algorithm, a percentage of power-up adjust commands which would normally be generated when E b/N o measurements for served mobiles do not meet target E b/N o levels are converted to power down-adjust commands, thereby forcing some mobiles to reduce transmit power, at least temporarily, to constrain interference. When the increased interference condition persists, the percentage of power-up adjust commands which are converted to power-down commands may be changed. According to the modified ROLPC algorithm, the power control processor adjusts target E b/N o levels in a centralized manner based on an overall system state so that only a limited number of target E b/N o levels are allowed to increase when frame erasures occur. By preventing a percentage of target E b/N o level increases, at least temporarily, when frame erasures occur, a percentage of power up-adjust commands are avoided. Therefore, a similar effect to that achieved by the modified RILPC is achieved. In accordance with still a further implementation of the present invention, the modified RILPC algorithm may be used in combination with the modified ROLPC algorithm to provide greater resistance to increased interference conditions.

en

METHOD AND APPARATUS FOR CONTROLLING REVERSE LINK INTERFERENCE RISE AND POWER CONTROL INSTABILITY IN A WIRELESS SYSTEM

5248976_US

12488887_US,16637841_US,16647775_US,16584724_US,12509767_US

H04B 7/26,H04W 52/146,H04W 52/24

2020-05-20

Y

The present invention relates to a method for analyzing operation reliability of a multi-state power generation system based on a decision diagram, comprising the following steps: step 1. establishing a multi-state power generation system model with reserve according to collected multi-state power generation system characteristic data; step 2. establishing a multi-state decision diagram of a power generation system according to the multi-state power generation system model with reserve established in step 1; and step 3. calculating the occurrence probability of a reliability path in the multi-state decision diagram of the power generation system established in step 2, and calculating the operation reliability of the power generation system according to the occurrence probability of the reliability path in the multi-state decision diagram of the power system. The present invention can be used for power supply systems with different state transfer rates or different state transfer time distributions. Generator sets 321 Number of generator sets States of generator sets Capacities of states of - Generatorsets generator sets /System for analyzing operation reliability of a multi-state power generation system 1. Modeling of a multi-state generator set 2. Establishment of a multi-state decision diagram of a system 3. Calculation of occurrence probability of a reliability path in the decision diagram State transfer 4. Calculation of system operation reliability characteristics of the sets System 0 in the operating mode load State transfer demand characteristics of the sets Firststate in the reserve mode transfer Generator Generator A set 1: 1-+2 esetoN r l-2 0 [setJN: Operation reliability of the multi-state power generation system • •Load ( demand

en

METHOD FOR ANALYZING OPERATION RELIABILITY OF MULTI-STATE POWER GENERATION SYSTEM BASED ON DECISION DIAGRAM

18640725_CN

36960221_,75180579_,72773246_,76466977_,75493647_,74342815_,29339117_

G06Q 50/06,Y04S 10/50

2004-06-18

N

Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combination s of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the field s of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the s ub- micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellul ar machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optic al interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or i n the alternative the principles of LCI and LSS can be combined to result in systems of the present invention

en

SYSTEMS AND METHODS FOR PHASE MEASUREMENTS

5298000_US

13265852_US,16701964_US,12592014_US,16865153_US,16865152_US,16701965_US

G01B 9/02007,G01B 9/0209

2021-06-25

Y

A remote sensing image semantic segmentation method based on self-supervised comparative learning is provided and includes: building a semantic segmentation network model; pre-training an encoder of the semantic segmentation network model by using unlabeled data; performing a supervised semantic segmentation training on labeled samples to obtain a trained network model after the pre-training; performing a semantic segmentation on a remote sensing image by using the trained network model after the supervised semantic segmentation training; and performing a contrastive learning by using a method of combining global style contrast and local matching contrast in a process of the pre-training. The invention applies contrastive self supervised learning to remote sensing semantic segmentation dataset, proposes a framework of global style and local matching contrastive learning, and forms a remote sensing image semantic segmentation method based on contrastive self-supervised learning, which makes the semantic segmentation method have a wide application range and better segmentation effect. 21005ZCM-AUP2 Building a DeepLab V3+ network model Pre-training an encoder of the DeepLab V3+ network model by using unlabeled data Performing a supervised semantic segmentation training on labeled samples to obtain a trained network model after the pre-training Performing a semantic segmentation on a remote sensing image by using the trained network model after the supervised semantic segmentation training Contrast of matched local region patch patch2 Select local feature t g() 1 ~ Center style correspondence _ Contrast of global style Maximize agreement Maximize agreement S g(•) (•(x t - --- - - avg avg Select local feature * patch1 patch2 21005ZCM-AUP2

en

REMOTE SENSING IMAGE SEMANTIC SEGMENTATION METHOD BASED ON CONTRASTIVE SELF-SUPERVISED LEARNING

82783940_CN,18138654_CN

47655582_,82256486_,37839718_,51778313_,37799251_,82302716_,11567555_,82078805_,80116419_

G06K 9/6259,G06N 3/0454,G06N 3/08,G06V 10/267,G06V 10/443,G06V 10/757

2020-05-29

N

A big data-based answer position acquisition method, relating to the field of artificial intelligence. Said method comprises: obtaining text information and question information to be processed, separately performing vectorization on each word in the text information and the question information, and obtaining word vectors corresponding to the text information and word vectors corresponding to the question information (S101); performing feature extraction on the word vectors corresponding to the question information by means of a bidirectional recurrent neural network Bi-LSTM, compressing an extracted multi-dimensional feature matrix to a preset dimension, and obtaining question encoding information (S102); adding a position vector and the question encoding information to each word vector of the text information, and obtaining text encoding information corresponding to the text information (S103); performing feature extraction on the text encoding information by means of multiple preset convolutional layers, and obtaining text feature information corresponding to the text information (S104); performing sequence tagging on the text feature information by means of a bidirectional recurrent neural network Bi-LSTM, and obtaining a first probability and a second probability of each word in the text information (S105); obtaining a word corresponding to a largest first probability value to serve as an answer starting position, and a word corresponding to a largest second probability value to serve as an answer ending position (S106). The present invention implements answer predictive analytics and solves the problem where current question and answer models have a large amount of parameters and a long time is expended on algorithm training.

en

BIG DATA-BASED ANSWER POSITION ACQUISITION METHOD, APPARATUS, DEVICE, AND MEDIUM

63942312_CN

63604368_CN,67315619_CN,81584329_CN

G06F 16/3329,G06F 16/3346,G06F 16/3347

2019-12-05

N

Optical fingerprints for label-free high-throughput (epi)genomics, transcriptomics, and proteomics profiling of single cells. Vibrational spectroscopy signatures combined with a molecular identification algorithm rooted in machine learning enables identification of nucleic acids and amino acids, and their molecular variations, thereby identifying genetic variation by mapping heterogeneity and identifying low copy-number variants. Additional embodiments include the BOCS algorithm which takes measurements of DNA k-mer content from high-throughput single-molecule Raman spectroscopy measurements and maps them to gene databases for probabilistic determination of genetic biomarkers at low coverages. Starting with a log of measured k-mer content blocks (B1 . . . Bn as shown) and a genetic biomarker database (excerpts from the MEGARes antibiotic resistance database are shown), the blocks are individually aligned to each gene in the database based on content. This alignment consists of finding all match locations for the k-mer block content within a gene via translating through the gene one nucleotide at a time and looking at fragments of length k. For each block, a raw probability can be calculated for each gene based on the number of matches for the k-mer block content within the gene, length of the k-mer block, and length of the gene (calculation shown in the schematic). As more blocks are analyzed, probabilities are compounded and genes in the database are ranked. The gene(s) from which the Raman-analyzed k-mer blocks originate quickly generate the top probabilities and can often be determined in coverages <<1.0, meaning that only a small fraction of the gene blocks need to be analyzed for identification of a specific genetic biomarker.

en

SINGLE-MOLECULE OPTICAL SEQUENCE IDENTIFICATION OF NUCLEIC ACIDS AND AMINO ACIDS FOR COMBINED SINGLE-CELL OMICS AND BLOCK OPTICAL CONTENT SCORING (BOCS): DNA K-MER CONTENT AND SCORING FOR RAPID GENETIC BIOMARKER IDENTIFICATION AT LOW COVERAGE

5676118_US

74745258_US,52660121_US,74838110_US,74700608_US

G01J 3/44,G01N 21/658,G06F 17/18,G16B 15/00,G16B 20/00,G16B 30/10,G16B 30/20,G16B 40/10,G16B 40/30

2015-09-09

Y

Fujitsu Ref. No.: 14-01621 A three-dimensional coordinate computing apparatus includes an image selecting unit and a coordinate computing unit. The image selecting unit selects a first selected image from multiple captured images, and selects a second selected image from multiple subsequent images captured by the camera after the first selected image has been captured. The second selected image is selected based on a distance between a position of capture of the first selected image and a position of capture of each of the multiple subsequent images and the number of corresponding feature points, each of which corresponds to one of feature points extracted from the first selected image and one of feature points extracted from each of the multiple subsequent images. The coordinate computing unit computes three-dimensional coordinates of the multiple corresponding feature points based on two-dimensional coordinates of each corresponding feature point in the first and second selected images. CN cy') CN L-U- Q- cl- C/D LU cf3 LU (D LU Lu C)- Lu I F) LU (D Lu D ClU:) C) C) LU F) (If (D AFT (D CD CD U:) C) D Of C:) n LU LU C)_ LU M CO CD LU LU LU C'e) CO CD LU LU LU C) (D I CD 4 LU LU C/D (If x CY) C/D Lu Lu C) LU C) m Q ------- LU CN.-,: LU co Q -< cn OBTAIN IMAGE s11 DETECT MARKER S12 COMPUTE POSITION AND Si 3 ATTITUDE INFORMATION , S14 /CAMERA POSITION DETERMINATION NUMBER /1 0 Si5 ,XTRCT TRACK FEATURE POINT NO IS THERE USER INPUT?: S20 YES S21 STORE AS FIRST IMAGE CE PIOTE E IAGE (--,,l7 -, S21 C OIS CONDITION SATISFIED? REXTRACT FEATURE POINT / NO STOYEA S 22IAG INCREMENT CAMERA POSITION8 STRFSSCNMG DETERMINATION NUMBER COMPUTE COORDINATES OF CORRESPONDING FEATURE POINT , S142 CONVERT COORDINATES, REGISTER ON FEATURE POINT MAP END )

en

Three-dimensional coordinate computing apparatus, three-dimensional coordinate computing method, and non-transitory computer readable recording medium having therein program for three-dimensional coordinate computing

5273619_JP

53112455_,52851270_,53111320_

G06T 7/579,G06T 7/593,G06T 7/73,G06T2207/30208,G06T2207/30244,G06V 10/44

1980-07-04

Y

In a speech processor for controlling a hearing prosthesis, an implanted electrode array stimulates the auditory nerve fibres of a patient by the application of electrical currents to selected electrodes in the array. The processing system comprises means for generating an input signal corresponding to a received speech signal, means for estimating the amplitude and frequency of the fundamental voicing and second formant components of the speech signal, and means for determining whether the speech signal is voiced or unvoiced. Programmable means produce instruction data which in use causes the application of the electrical currents to selected electrodes in the array. The programmable means is programmed with data defining a predetermined relationship between each electrode and a selected range of second formant frequencies based on psychophysical testing of the patient and causing selection of the electrodes based on the estimated-frequency of said second formant component such as to produce the desired percepts in the auditorylike sensations generated in the patient. The selected electrode is stimulated at a frequency dependent on the estimated frequency of said fundamental voicing component for voiced speech signals and at a lower substantially constant frequency for unvoiced speech signals. The programmable means also produces data which determines the level of stimulation of each selected electrode dependent on the estimated amplitude of the second formant component of the speech signal as well as on predetermined data relating to the sensitivity of each electrode implanted in the patient. By providing an output signal in which both formant and prosodic information is present, the production of confusing precepts is avoided.

en

SPEECH PROCESSOR FOR CONTROLLING HEARING PROSTHESIS

16020385_

16048946_,16020587_,16020589_,16020386_,16048947_

A61F 11/04,A61N 1/36038,A61N 1/36039,G10L 25/00,G10L 25/93,H04R 25/505,H04R2225/43

2015-08-31

Y

The present disclosure relates to systems and processes for monitoring attributes of a user's physical activity or inactivity, and for generating user interfaces for displaying the same. One example user interface can include a first indicator that represents an attribute of a user's physical activity that is of a first type and a second indicator that represents an attribute of a user's physical activity that is of a second type. The first type of physical activity can be a physical activity that meets a first set of criteria and the second type of physical activity can be a physical activity that meets a second set of criteria. The user interface can further include a third indicator that represents an attribute of a user's inactivity, which can include the user not performing a specified type of physical activity or not performing a physical activity that meets a third set of criteria. The present disclosure also relates to systems and processes for monitoring a user's workout, and for generating user interfaces for displaying the same. One example process can include monitoring a user's physical activity during a workout (e.g., a session of physical activity or exercise) using activity sensors selected based on the type of workout. The process can further include generating a user interface for displaying one or more attributes of the workout. One example user interface can include a first indicator (e.g., a visual representation) that represents a first attribute of the workout and a second indicator (e.g., a visual representation) that represents a second attribute of the workout. The process can further include providing notifications during the workout to notify the user of significant events associated with the workout.

en

Physical activity and workout monitor

12474688_US

53159305_US,50082180_US,52092543_US,53103611_CA,54244495_US,50063189_US,54311040_US,44430241_US,52973908_US,54337342_US,54329696_US,43327512_US,43120714_GB,51829306_GB

A61B 5/103,A61B 5/1112,A61B 5/1116,A61B 5/1118,A61B 5/1123,A61B 5/6801,A61B 5/7435,A61B2503/10,A63B2024/0068,G06F 3/048,G06F 3/04817,G06F 3/0482,G16H 20/30,G16H 20/40

2003-06-23

N

8-(biaryl) quinolines wherein the bi-aryl group at the 8-position is in a me ta relationship to the quinoline group, are PDE4 inhibitors useful in the treatment of asthma, chronic bronchitis, chronic obstructive pulmonary disease, eosinophilic granuloma, psoriasis and other benign or malignant proliferative skin diseases, endotoxic shock, laminitis in horses, colic in horses, septic shock, ulcerative colitis, Crohn's disease, reperfusion injur y of the myocardium and brain, inflammatory arthritis, chronic glomerulonephritis, atopic dermatitis, urticaria, adult respiratory distress syndrome, chronic obstructive pulmonary disease in animals, diabetes insipidus, allergic rhinitis, allergic conjunctivitis, vernal conjunctivitis , arterial restenosis, ortherosclerosis, atherosclerosis, neurogenic inflammation, pain, cough, rheumatoid arthritis, ankylosing spondylitis, transplant rejection, graft versus host disease, hypersecretion of gastric acid, bacterial, fungal induced sepsis, viral induced sepsis, fungal induced septic shock, viral induced septic shock, inflammation-mediated chronic tiss ue degeneration, cytokine-mediated chronic tissue degeneration, osteoarthritis, cancer, cachexia, muscle wasting, depression, memory impairment, tumour growth, or cancerous invasion of normal tissues.In another aspect, the prese nt invention is directed to a method of enhancing cognition in a healthy subjec t comprising administering a safe cognition enhancing amount of phosphodiesterase-4 inhibitor. In particular, this invention is directed to a method of enhancing memory, learning, retention, recall, awareness and judgement in health subjects comprising administering a safe and cognition enhancing amount of a phosphodiesterase-4 inhibitor.

en

8-(BIARYL) QUINOLINE PDE4 INHIBITORS

7436903_CA

13097740_CA,13097738_CA,13097737_CA,13097741_CA,13011136_CA,13135813_CA,13093847_CA

A61P 1/00,A61P 9/00,A61P 9/10,A61P 11/00,A61P 11/06,A61P 13/12,A61P 19/10,A61P 25/00,A61P 25/16,A61P 25/24,A61P 25/28,A61P 29/00,A61P 31/04,A61P 35/00,A61P 37/08,C07D 215/04,C07D 215/06,C07D 215/12,C07D 215/14,C07D 401/04,C07D 401/10,C07D 401/12,C07D 403/10,C07D 405/10,C07D 407/10,C07D 409/10,C07D 413/10,C07D 413/14,C07D 417/10,C07D 417/12,C07D 471/04,C07F 7/0812,C07F 9/60

2017-07-07

N

The invention discloses an electroencephalogram measuring device combining magneto-acoustic coupling and sound source localization and a monitoring method. The device comprises a power supply which is in charge of supplying power to an N pole electromagnet and an S pole electromagnet, and further comprises a teslameter which is used for detecting magnetic field intensity and a low-frequency acoustic detection array module which is used for detecting a sample acoustic signal, wherein a vibration isolation table and a sound insulating box which is arranged on the vibration isolation table are arranged between the N pole electromagnet and the S pole electromagnet; and a sample is arranged in the sound insulating box. The method comprises the following steps: insulating sound of a laboratory and making the sound insulating box; determining noise of an internal environment of the sound insulating box and saving the noise in a computer; judging whether the noise of the internal environment of the sound insulating box is lower than a preset laboratory noise threshold or not; applying a sound-conducting paste on the sample and keeping the sample in the sound insulating box, and fixing a low-frequency acoustic sensor array to the tested sample; electrifying the electromagnets; acquiring corresponding information on the basis of magneto-acoustic signals and saving the information in the computer; calculating positional information of electroencephalogram signals, so as to obtain a sound distribution image; and acquiring a final sound image. According to the device and the monitoring method provided by the invention, real-time precise localization of the electroencephalogram signals can be achieved by virtue of a plurality of sensors.

en

Electroencephalogram measuring device combining magneto-acoustic coupling and sound source localization and monitoring method

58921041_

60605559_,60997321_,59424095_

A61B 5/242,A61B 5/369,A61B 5/40,A61B2560/06

2001-03-05

Y

The present invention describes novel methods for treating and preventing dementia caused by vascular diseases; dementia associated with Parkinson's disease; Lewy Body dementia; AIDS dementia; mild cognitive impairments; age-associated memory impairments; cognitive impairments and/or dementia associated with neurologic and/or psychiatric conditions, including epilepsy, brain tumors, brain lesions, multiple sclerosis, Down's syndrome, Rett's syndrome, progressive supranuclear palsy, frontal lobe syndrome, and schizophrenia and related psychiatric disorders; cognitive impairments caused by traumatic brain injury, post coronary artery by-pass graft surgery, electroconvulsive shock therapy, and chemotherapy, administering a therapeutically effective amount of at least one of the cholinesterase inhibitor compounds described herein. The present invention also describes novel methods for treating and preventing delirium, Tourette's syndrome, myasthenia gravis, attention deficit hyperactivity disorder, autism, dyslexia, mania, depression, apathy, and myopathy associated with diabetes by administering a therapeutically effective amount of at least one of the cholinesterase inhibitor compounds described herein. The present invention also describes novel methods for delaying the onset of Alzheimer's disease, for enhancing cognitive functions, for treating and preventing sleep apnea, for alleviating tobacco withdrawal syndrome, and for treating the dysfunctions of Huntington's Disease by administering a therapeutically effective amount of at least one of the cholinesterase inhibitor compounds described herein. A preferred cholinesterase inhibitor for use in the methods of the present invention is donepezil hydrochloride or ARICEPT3.

en

NOVEL METHODS USING CHOLINESTERASE INHIBITORS

214639_JP

1116709_US

A61K 31/445,A61P 25/00,A61P 25/16,A61P 25/28

2012-08-21

N

An in vitro method of predicting a response for patients, having neurodevelopmental, neurological or neuropsychiatric disorders, if treated with a compound, targeting the glutamatergic pathway, comprises the steps i) determining the protein concentration of one, two, three, four five or six members of the complement factor H family or a mixture or a combination thereof in a sample of a patient and ii) comparing the protein concentration determined in step i) to a value representative of the protein concentration of one, two three, four, five or six members of complement factor H family in patients, having neurodevelopmental, neurological or neuropsychiatric disorders. A higher protein concentration of one, two three, four five or six members from complement factor H family in the sample of the patient having neurodevelopmental, neurological or neuropsychiatric disorders is indicative for a patient who will derive clinical benefit from this treatment. The method further comprises iii) selecting this treatment for patients having neurodevelopmental, neurological or neuropsychiatric disorders. Also disclosed is an in vitro method of predicting a response for patients, having neurodevelopmental, neurological or neuropsychiatric disorders, if treated with a compound targeting the glutamatergic pathway, wherein the protein concentration of individual members of the complement factor H family or a mixture or a combination thereof are determined by measuring genetic variants of complement factor H family members. Complement factor H family members are useful as predictive markers for patients who are treated with compounds targeting the glutamatergic pathway or for patients who are treated with a glycine reuptake inhibitor.

en

A method for predicting clinical benefit in the treatment of neurodevelopmental, neurological or neuropsychiatric disorders

8529723_

48605249_,32435681_,41977424_,38984740_,43785403_,19745984_,19740811_,48821192_,48723987_,46566064_

C12Q 1/6883,G01N 21/76,G01N 33/543,G01N 33/54366,G01N 33/6896

2013-04-23

N

A multi-core optical fiber comprises a plurality of cores each extending along a predetermined axis and arranged on a cross section perpendicular to the predetermined axis; and a cladding region integrally surrounding each of the cores, wherein the plurality of cores rotate around the predetermined axis, and wherein where an average twist rate defined as an average value of absolute values of angles of rotations of the cores per unit length along a longitudinal direction of the multi-core optical fiber is ³ (rad/m), the shortest distance between centers of the respective cores is A (m), a group index for a fundamental mode in each of the cores is ng, an in-use bending radius defined as a bending radius in use of the multi-core optical fiber is R (m), the speed of light in vacuum is c (m/s), and the ratio of the circumference of a circle to its diameter is À, the multi-core optical fiber satisfies at least one of first to third conditions and satisfies at least either of fourth and fifth conditions, the first condition being defined so that Expression: 2 n g › cR ³À is not more than 7.91×10-12 (s/ml/2), the second condition being defined so that in a state in which the multi-core optical fiber is wound on a bobbin with a radius Rbobbin (m), Expression: 2 n g › cR bobbin ³À is not more than 7.91×10-12×1/Rbobbin (s/m1/2), the third condition being defined so that the shortest distance A is not more than approximately 25×10-6 m and the average twist rate ³ is not less than approximately 4.72 rad/m, the fourth condition being defined so that the shortest distance A is not more than approximately 25×10-6 m, and the fifth condition being defined so that crosstalk between closest adjacent cores is not less than - 15 dB.

en

MULTI-CORE OPTICAL FIBER, MULTI-CORE OPTICAL FIBER CABLE, AND MULTI-CORE OPTICAL FIBER TRANSMISSION SYSTEM

54590601_JP

54540221_JP

G02B 6/02042,G02B 6/4401,G02B 6/4413