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Optogalvanic effect The is the change in the conductivity of a gas discharge induced by a light source (typically a laser). This effect has found many applications in atomic spectroscopy and laser stabilization. In general, light will couple to atomic transitions if the energy difference between atomic levels is in resonance with some of the frequencies of the incoming light, thereby exchanging energy and momentum. In a gas discharge, the gaseous medium is affected by light on resonance with the atoms or molecules in the gas, thus creating a new balance in the energetic properties of the medium. Since the medium consists of charged particles, it is not surprising that also its electrical properties change. | Natural_sciences | https://en.wikipedia.org/wiki?curid=37820320 | Optogalvanic effect | [
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Alfred James Wilmott (1888–1950) was primarily an English botanist and museum curator. His author standard form is Wilmott and his area of interest was spermatophytes. His father was an academic who taught at Homerton Training College. Wilmott entered St John's College, Cambridge and graduated from University in 1910. His mentor was Charles Edward Moss. Wilmott had an interest in "Salicornia" and did much work for the Natural History Museum. Although botany and museum work was his career he also played table tennis receiving the title for the Veteran Singles Champion in 1934-1935. In table tennis he also introduced a method for testing table tennis balls. | Natural_sciences | https://en.wikipedia.org/wiki?curid=37824899 | Alfred James Wilmott | [
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Hercules A is a bright astronomical radio source within the vicinity of the constellation Hercules corresponding to the galaxy 3C 348. During a survey of bright radio sources in the mid-20th century, astronomers found a very bright radio source in the constellation Hercules. The radio source is strongest in the middle range frequency and emits synchrotron radiation, suggesting the source of radio emission may be gravitational interaction. In 1959, astronomers from the Radio Astronomy Group (later the Cavendish Astrophysics Group) detected the radio source using the Cambridge Interferometer of the Cavendish Observatory in Cambridge University in United Kingdom, including it in the Third Cambridge Catalogue of Radio Sources (3C) as 3C 348, the 348th object detected by the survey. The galaxy, 3C 348, is a supergiant elliptical galaxy. It is classified as type E3 to E4 of the updated Hubble–de Vaucouleurs extended galaxy morphological classification scheme. Little else is known about the galaxy. 3C 348, the galaxy at the image center, appears to be a relatively normal elliptical galaxy in visible light. When imaged in radio waves, however, plasma jets over one million light years long appear. Detailed analyses indicate that the galaxy is actually over 1,000 times more massive (approx. 10 solar masses) than our Milky Way Galaxy, and the central black hole is nearly 1,000 times more massive (approx. 4 billion solar masses) than the black hole at our Milky Way's center, one of the largest known | Natural_sciences | https://en.wikipedia.org/wiki?curid=37849924 | Hercules A | [
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Hercules A The physics that creates the jets is poorly understood, with a likely energy source being matter ejected perpendicular to the accretion disc of the central black hole. | Natural_sciences | https://en.wikipedia.org/wiki?curid=37849924 | Hercules A | [
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Transposon silencing is a form of transcriptional gene silencing targeting transposons. Transcriptional gene silencing is a product of histone modifications that prevent the transcription of a particular area of DNA. Transcriptional silencing of transposons is crucial to the maintenance of a genome. The “jumping” of transposons generates genomic instability and can cause extremely deleterious mutations. Transposable element insertions have been linked to many diseases including hemophilia, severe combined immunodeficiency, and predisposition to cancer. The silencing of transposons is therefore extremely critical in the germline in order to stop transposon mutations from developing and being passed on to the next generation. Additionally, these epigenetic defenses against transposons can be heritable. Studies in "Drosophila", "Arabidopsis thaliana", and mice all indicate that small interfering RNAs are responsible for transposon silencing. In animals, these siRNAS and piRNAs are most active in the gonads. Piwi-interacting RNA (piRNA), the largest class of the small RNAs, are between 26 and 31 nucleotides in length and function through interactions with piwi proteins from the Argonaute protein family (gene silencing proteins). Many piRNAs are derived from transposons and other repeated elements, and therefore lack specific loci. Other piRNAs that do map to specific locations are clustered in areas near the centromeres or telomeres of the chromosome. piRNA clusters make up ~1% of the genome (Khurana, 4) | Natural_sciences | https://en.wikipedia.org/wiki?curid=37879288 | Transposon silencing | [
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Transposon silencing piRNAs were first observed in Drosophila in 1990 (Johnson, 2). In 2003, piRNAs derived largely from repeated sequence elements, including transposons, were found in abundance in male and female "Drosophila" germlines (Theurkauf, 5). Since then, several studies have identified various piRNAs and piwi-pathways involved in transposon silencing in various species. Two such genome defense systems against transposons are the silencing of the MuDR transposon in maize and the silencing of P elements in "Drosophila". In 2006, a study by Margaret Roth Woodhouse, Michael Freeling, and Damon Lisch identified a gene that inhibits the transcription of both transposons and paramuted color gens in maize (Woodhouse, 6). The gene, called "Mediator of paramutation1" (Mop1), codes for an RNA-processing enzyme that is necessary for making the small RNAs that are responsible for silencing the transposon MuDR. A second gene, Mu killer (MuK), is then needed to establish heritable silencing (Gross, 1). P elements are a family of transposons that recently proliferated within the genome of "Drosophila melanogaster". The P elements have an extremely high transposition rate and induce sterility and abnormal gonad development in "D. melanogaster" (Johnson, 2). The flies thus developed a maternally inherited technique for combating the invasive DNA and silencing the transposons, now known as P cytotype | Natural_sciences | https://en.wikipedia.org/wiki?curid=37879288 | Transposon silencing | [
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Transposon silencing P cytotype detects DNA sequences in areas of telomeric heterochromatin and silences those sequences when they are found elsewhere in the genome. This is referred to as the telomeric-silencing effect (TSE) (2). Just two P elements in the telomere are enough to suppress over 80 other copies of the P element in the genome. The cytoplasmic factor used for TSE builds up over generations and suppression of the transposons is not fully effective unless the fly’s female-line ancestors have had the P element for six generations (2). | Natural_sciences | https://en.wikipedia.org/wiki?curid=37879288 | Transposon silencing | [
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Booming Ice Chasm is an ice cave in the Crowsnest Pass area of the Canadian Rockies. It is a cold-trap cave, where cold air enters the cave and is unable to leave, resulting in the entrance pitch and floor being covered in several metres of clear, smooth ice. The name derives from the acoustics of the cave. It was discovered, explored and mapped in 2008 by the Alberta Speleological Society. An expedition led by Nicholaus Vieira was filmed by François-Xavier de Ruydts and became a 19-minute documentary, which takes the viewer inside the cave. | Natural_sciences | https://en.wikipedia.org/wiki?curid=37893194 | Booming Ice Chasm | [
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Prochymal is a stem cell therapy made by Osiris Therapeutics. It is the first stem cell therapy approved by Canada. It is also the first therapy approved by Canada for acute graft-vs-host disease (GvHD). It is an allogenic stem therapy based on mesenchymal stem cells (MSCs) derived from the bone marrow of adult donors. MSCs are purified from the marrow, cultured and packaged, with up to 10,000 doses derived from a single donor. The doses are stored frozen until needed. In May 2012 Health Canada approved the use of for the management of acute GvHD in children who are unresponsive to steroids, with the approval conditional upon further trials being conducted. Preliminary results of a phase III trial for GvHD were released in Sept 2009. | Natural_sciences | https://en.wikipedia.org/wiki?curid=37903929 | Prochymal | [
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HealthCap is a specialized provider of venture capital within life sciences. invests in innovative companies with focus on therapeutics. As of 2017, has invested in over 100 companies since inception and completed initial public offerings of more than 40 companies. has offices in Stockholm, Oslo and Lausanne. The firm was founded in 1996 by Björn Odlander and Peder Fredrikson, and the first fund was started the same year. As of 2017, has established seven funds and financed 106 companies, where 39 have been taken public on nine different markets. The most recent fund, VII, was established in the fall of 2015. In 2017, had approximately 23 employees out of which ten are partners. The team combines venture capital investing experience with competencies and work experiences from small as well as large companies across the healthcare industry, spanning disciplines of scientific research, drug development, clinical practice, investment banking, and industry management. has raised seven main funds. IV-VII are Delaware Limited Partnerships with Swiss general partners. Investors in funds include, among others, European Investment Fund, Skandia Life Insurance, the 4th and 6th Swedish National Pension Funds, The Kresge Foundation, Mayo Clinic, Northwestern University, University of Michigan, Vanderbilt University and Washington University. has committed capital exceeding EUR 1 billion. invests in companies developing disruptive technologies that hold the potential to change clinical practice | Natural_sciences | https://en.wikipedia.org/wiki?curid=37926891 | HealthCap | [
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HealthCap Over the years has invested in more than 100 companies. The portfolio companies have developed more than 20 pharmaceutical products and over 40 med-tech products to the market. Many of these products, such as Firazyr®, Xofigo®, Tracleer®, are breakthrough therapies addressing life-threatening diseases. Examples of technologies financed by are | Natural_sciences | https://en.wikipedia.org/wiki?curid=37926891 | HealthCap | [
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Echelon cracks are a related series of cracks in a planar structure and are a response to shearing forces in the plane of the surface. Such cracks are typically found in asphalt roadways due to aseismic creep and in other planar structures such as walls and building facades due to non-uniform settlement into soft soil. Such cracks in a uniform surface will form at a uniform angle to the general direction of shear and will progress with more-or-less uniform spacing, length, and offset, thus forming the echelon. On a larger scale, a zone between offset strike slip faults may have minor "en echelon" fault strands that accommodate the shearing motion induced in the region. On rock undergoing these shearing stresses en echelon veins may occur as fracture fillings. | Natural_sciences | https://en.wikipedia.org/wiki?curid=37940531 | Echelon cracks | [
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Nb.BbvCI is a nicking endonuclease used to cut one strand of double-stranded DNA. It has been successfully used to incorporate fluorochrome-labeled nucleotides into specific spots of a DNA sequence via nick translation. | Natural_sciences | https://en.wikipedia.org/wiki?curid=37959176 | Nb.BbvCI | [
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AURIGA ("Antenna Ultracriogenica Risonante per l'Indagine Gravitazionale Astronomica") is an ultracryogenic resonant bar gravitational wave detector in Italy. It is at the Laboratori Nazionali di Legnaro of the Istituto Nazionale di Fisica Nucleare, near Padova. It is being used for research into gravitational waves and quantum gravity. When the oscillator gets hit with a burst of gravitational waves, it will excite the oscillator and it will vibrate for a time span longer than the duration of the gravitational wave burst. This allows for the extraction of the signal from the detector. | Natural_sciences | https://en.wikipedia.org/wiki?curid=37965697 | AURIGA | [
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Guido Georg Wilhelm Brause (7 August 1847 in Kochanowitz – 17 December 1922) was a German botanist, specializing in ferns. Brause studied at Koszęcin, in Poland. Along with his botanical career he continued throughout his life a military career, first in the artillery during the Franco-Prussian War of 1870, then as an officer in Charlottenburg, with an expedition to Central Africa in 1907–1908. In retirement, he was associated with the botanical garden and museum in Berlin as well as the "Botanischer Verein der Provinz Brandenburg" (Botanical Association of Brandenburg Province). | Natural_sciences | https://en.wikipedia.org/wiki?curid=37972942 | Guido Georg Wilhelm Brause | [
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Anupam Garg is a professor in the department of Physics & Astronomy at Northwestern University, Illinois. He received his Ph.D. in 1983 from Cornell University. In 2012 he became a Fellow of the American Physical Society (APS) thanks to his work on molecular magnetism and macroscopic quantum phenomena. Garg is best known for formulating the Leggett–Garg inequality, named for Anthony James Leggett and himself, which is a mathematical inequality fulfilled by all macrorealistic physical theories. He is also known for the Garg-Onuchic-Ambegaokar model of charge transfer. His current research interests center around quantum and semi-classical phenomena associated with the orientation of quantum mechanical spin. Garg is the author of a graduate physics textbook, "Classical Electromagnetism in a Nutshell". | Natural_sciences | https://en.wikipedia.org/wiki?curid=37982024 | Anupam Garg | [
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Mark Meier Mark F. Meier (December 19, 1925 – November 25, 2012) was an American glaciologist who was considered a leading expert on the study of rising sea levels due to the melting of glaciers. Meier was the Director of the Institute of Arctic and Alpine Research (INSTAAR) from 1985 to 1994 and remained the institute's director emeritus until his death in 2012. He was also a professor of geological sciences at the University of Colorado - Boulder. Meier was born and raised in Iowa. He resided in Boulder, Colorado, since 1985. In 1956, Meier founded the U.S. Geological Survey's department of glaciology. He obtained doctorate in 1957 from the California Institute of Technology. Meier served as the director of the U.S. Geological Survey's Project Office of Glaciology in Tacoma, Washington, until he became the director of INSTAAR in 1985. Meier was one of the first glaciologists to use remote sensing to study glaciers and rates of melting. He headed several studies of tidewater glacier dynamics in the U.S. state of Alaska. Meier organized the systematic measurement and assessment of glacier mass balance within North America to mark the International Geophysical Year and International Hydrological Decade, which was observed from 1965 to 1975. His numerous recognitions and awards included the Seligman Crystal from the International Glaciological Society in 1985, the Robert E | Natural_sciences | https://en.wikipedia.org/wiki?curid=37989327 | Mark Meier | [
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Mark Meier Horton Medal in 1996, three medals from the USSR Academy of Sciences (now the Russian Academy of Sciences) and the United States Department of the Interior's Distinguished Service Award. Meier died in Boulder, Colorado, on November 25, 2012, at the age of 86. He is survived by his wife, Barbara, his children, Lauren Meier, Gretchen Meier, and Mark S. Meier, and his seven grandchildren. | Natural_sciences | https://en.wikipedia.org/wiki?curid=37989327 | Mark Meier | [
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Road Weather Information System A (RWIS) comprises automatic weather stations (technically referred to as Environmental Sensor Stations (ESS)) in the field, a communication system for data transfer, and central systems to collect field data from numerous ESS. These stations measure real-time atmospheric parameters, pavement conditions, water level conditions, and visibility. Central RWIS hardware and software are used to process observations from ESS to develop nowcasts or forecasts, and display or disseminate road weather information in a format that can be easily interpreted by a manager. RWIS data are used by road operators and maintainers to support decision making. Real-time RWIS data is also used by Automated Warning Systems (AWS). The spatial and temporal resolution can be that of a mesonet. The data is often considered proprietary although it is often ingested into numerical weather prediction models. | Natural_sciences | https://en.wikipedia.org/wiki?curid=37997242 | Road Weather Information System | [
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Frozen star (hypothetical star) In astronomy, a frozen star, besides a disused term for a black hole, is a type of hypothetical star that, according to the astronomers Fred Adams and Gregory P. Laughlin, may appear in the future of the Universe when the metallicity of the interstellar medium is several times the solar value. Frozen stars would belong to a spectral class "H". Due to opacity effects, as metallicity of the interstellar gas increases both the maximum and minimum masses a star can have will decrease. For the latter case, it's expected that an object with a mass of 0.04 solar masses (40 times the mass of Jupiter), that currently would become a brown dwarf unable to fuse hydrogen, could do so ending in the main sequence with a surface temperature of 0 °C (273 K, thus "frozen"), much cooler than the dimmest red dwarfs of today, and ice clouds forming in its atmosphere. The luminosity of these objects would be more than a thousand times lower than the faintest stars currently existing and their lifetimes would also be sensibly longer. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38007267 | Frozen star (hypothetical star) | [
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Natural History Museum of Nepal The is located near the World Heritage Site of Swayambhunath. The museum was established in 1975. Since then the museum has collected 50,000 specimens of Nepal’s flora and fauna. The has been publishing a journal annually since 1977. The journal, entitled the "Journal of Natural History Museum", is the oldest journal on nature in Nepal. The museum has also published numerous books and field guides on Nepal's wildlife. The museum is the scientific authority in fauna for CITES (Convention on International Trade in Endangered Species of Wild Fauna and Flora) in Nepal. It conducts training programs on CITES-related issues for teachers, students, and people working in Nepal’s conservation sector. The museum's huge specimen collection is a treasure trove of Nepal's bio-diversity. There are 14,843 specimens of butterflies and moths; 4,142 of beetles; 1,464 of dragonflies and 1,604 of other insects. It also has six specimens of lower chordates, 890 of fish, 107 amphibians specimens, 390 of reptiles and 1,194 of birds. The museum's mammalian specimens total 225, and it also has 22 specimens of skeletons, besides 964 fossils and animal body parts. The museum also houses 107 models of plastic-clay and 74 of rock and minerals. Equally impressive is the museum's botanical and mycological collection: algae (124), fungi and mushrooms (2,320), lichens (61), bryophytes (1,124), pteridophytes (507), gymnosperms (163), and angiosperms (5,034). The museum also has a specimen of the spiny babbler, Nepal's only endemic bird species | Natural_sciences | https://en.wikipedia.org/wiki?curid=38029018 | Natural History Museum of Nepal | [
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Natural History Museum of Nepal A specimen of the golden pheasant, an exotic bird from China, is also on display. Also on display is a specimen of the Atlas moth, the largest moth species in the world. The museum is now the only place to see a specimen of the mouse deer (Indian chevrotain), which is believed to be extinct in Nepal. The museum has some bizarre specimens, among them an eight-legged embryo of a goat, a four-legged chick, and a two-headed snake. The museum also some relics from the country's prehistoric times. There is a fossilized skull of the "Archidiskodon", a species of elephant that roamed the Sivalik Hills of Nepal. Another ancient specimen is the molar teeth of "Sivapithecus", a hominoid. The skull and the teeth are believed to be from around 3 million years and 8-10 million years old respectively. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38029018 | Natural History Museum of Nepal | [
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Duília de Mello (born 27 November 1963) is a Brazilian astronomer. She is a professor at the Catholic University of America. She is also a research associate at NASA Goddard Space Flight Center. Her research is mainly on galaxies. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38035015 | Duília de Mello | [
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] |
100K Pathogen Genome Project The was launched in July 2012 by Bart Weimer (UC Davis) as an academic, public, and private partnership. It aims to sequence the genomes of 100,000 infectious microorganisms to create a database of bacterial genome sequences for use in public health, outbreak detection, and bacterial pathogen detection. This will speed up the diagnosis of foodborne illnesses and shorten infectious disease outbreaks. The is a public-private collaborative project to sequence the genomes of 100,000 infectious microorganisms. The 100K Genome Project will provide a roadmap for developing tests to identify pathogens and trace their origins more quickly. Partners announced in the launch of the project were UC Davis, Agilent Technologies, and the US Food and Drug Administration, with the US Centers for Disease Control and Prevention and the US Department of Agriculture noted as collaborators. As the project has proceeded, the partnership has evolved to include or replace these founding partners. The was selected by the IBM/Mars Food Safety Consortium for metagenomic sequences. The is conducting high-throughput next-generation sequencing (NGS) to investigate the genomes of targeted microorganisms, with whole genome sequencing to be carried out on a small number of microorganisms for use as a reference genome. Most bacterial strains will be sequenced and assembled as draft genomes; however, the project has also produced closed genomes for a variety of enteric pathogens in the 100K bioproject | Natural_sciences | https://en.wikipedia.org/wiki?curid=38036756 | 100K Pathogen Genome Project | [
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100K Pathogen Genome Project Data from this project is also available for download at the website. This strategy enables worldwide collaboration to identify sets of genetic biomarkers associated with important pathogen traits. This five-year microbial pathogen project will result in a free, public database containing the sequence information for each pathogen's genome. The completed gene sequences will be stored in the National Institutes of Health (NIH)'s National Center for Biotechnology Information (NCBI)'s public database. Using the database, scientists will be able to develop new methods of controlling disease-causing bacteria in the food chain. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38036756 | 100K Pathogen Genome Project | [
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Despeciation is the loss of a unique species of animal due to its combining with another previously distinct species. It is the opposite of speciation and is much more rare. It is similar to extinction in that there is a loss of a unique species but without the associated loss of a biological lineage. has been noted in species of butterflies, sunflowers, mosquitoes, fish, wolves, and even humans. A prime example of despeciation is convergent evolution due to the fact that it causes two species that live in same environment to become the same due to the similar functions and behaviors that it must partake in to survive in that habitat. Common examples of convergent evolution are Mullerian and Batesian mimicry. Batesian mimicry is when one species that is harmless mimics a more threatening, or intimidating, species as to prevent it from being killed. Mullerian mimicry is when two organisms mimic each other as to prevent either species from being killed by predators. also occurs when two diverged species begin to interact in the same region, as in the case of Holarctic and Californian ravens in North America. Holarctic Ravens and Californian Ravens had been two separate species for 1.5 million years until tens of thousands of years ago when their regions overlapped and they began to merge into a new species. This new raven species contains genes coming from both the Holarctic and Californian Raven. This was possible because they occupy the same area of the Western United States | Natural_sciences | https://en.wikipedia.org/wiki?curid=38045209 | Despeciation | [
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Despeciation Another possible cause for despeciation is increased gene flow and hybridization due to changes in the environment. One of these changes could include the loss of essential nourishment resources for each individual species. For example, Taylor et al.'s genetic analysis of three-spined sticklebacks across six lakes in southwestern British Columbia found two distinct species in 1977 and 1988 but only one combined species in data from 1997, 2000, and 2002. The new species is a hybrid and shows an intermediate form of the parental genotype. They concluded that external factors had imperiled the living conditions of the two species, thus eliminating the evolutionary specializations that had kept them unique. Human beings are considered to have undergone despeciation due to the genomes associated with early human remains like the Denisovans and Neanderthals, among others. These genomes show that human ancestors interbred with these other hominins. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38045209 | Despeciation | [
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Leaf scar A leaf scar is the mark left by a leaf after it falls off the twig. It marks the site where the petiole attached to the stem. A leaf scar is typically found below a branch as branches come from axillary buds located above leaf scars. Leaf scars are formed naturally, often at the end of the growing season for deciduous plants when a layer of cells called the abscissa layer forms between the petiole and stem. The abscission layer acts as a point of cleavage and the leaf breaks off leaving a cleanly shaped wound that is quickly healed over with protective cork. Stipules may also leave their own scars if they are present. Bundle scars are circular or barred regions within the leaf scar where bundles of vascular tissue that had connected the leaf and the stem broke off. The number of bundle scars in a leaf scar is sometimes used as an identifying mark as they are often consistent across a species. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38051614 | Leaf scar | [
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Sex reversal is a biological process whereby the pathway directed towards the already determined-sex fate is flipped towards the opposite sex, creating a discordance between the primary sex fate and the sex phenotype expressed. The process of sex reversal occurs during embryonic development or before gonad differentiation. In GSD species sex reversal means that the sexual phenotype is discordant with the genetic/chromosomal sex. In TSD species sex reversal means that the temperature/conditions that usually trigger the differentiation towards one sexual phenotype are producing the opposite sexual phenotype. can occur naturally, by mutations, or can be induced artificially. can be genetically or hormonally induced in laboratory. It can also occur artificially by exposure to endocrine disruptors such as pollutants, including herbicides, which can act as estrogen promoters or inhibitors, for instance by altering aromatase expression. In gonochoristic fishes, the sex can be determined genetically, environmentally or by a combination of both. In fishes, primary sexual fate can be susceptible to alteration by hormones exposure and multiple environmental factors, such as population density, water pH, or temperature. Those conditions can affect the gonad development and differentiation, which can lead to sex reversal. In medaka fish, where sex reversal has been documented show a shared gene related to normal male development, the "dmy" gene | Natural_sciences | https://en.wikipedia.org/wiki?curid=38053611 | Sex reversal | [
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Sex reversal In wild populations, genetically female fate can be phenotypically reversed to males if they carry the "dmy" gene or a mutated "dmy" gene and genetic males can be reversed to females if they lack the "dmy" gene. In aquaculture, sex control is important due to the role of sex in growth and reproduction. In fishes, growth rates can be different between sexes. These differences can affect their economic value. Producing a monosex fish population can improve product quality and therefore generates higher financial profit. Hormone-induced sex reversal is the most frequent method used in aquaculture. It consists of exposing sexually undifferentiated fishes to sex steroids. There are other methods to induced sex reversal in fishes such as chromosomal/genetic manipulation, hybridization, or treatments influencing sex determination or gonad differentiation (e.g. temperature, population density, pH, social factors). Sex is genetically determined in amphibians. Temperature-induced sex reversal has been documented in some species of anuran and caudate amphibians. Temperature only can have an effect on sex differentiation during a window period called thermosensitive period (TSP) which varies among species. Tadpoles or larvae exposed to specific higher or lower temperatures, depending on the temperature thresholds of the species, can differentiate gonads that do not align with their primary sexual fate. Amphibian sex reversal can be also induced by exposure to sex steroid and pollutants | Natural_sciences | https://en.wikipedia.org/wiki?curid=38053611 | Sex reversal | [
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Sex reversal Endocrine disruptors can affect gonad differentiation, and therefore induce sex reversal. Exposure to ethylnyl estradiol (EE) and bisphenol A (BPA) induces feminizing effects. Masculinizing effects can be induced by exposure to the drug trenbolone, used in cattle. Research in wild populations of the North American green frog has demonstrated that sex reversal is common. This work shows that genetic females sex reverse into phenotypic males and that genetic males sex reverse into phenotypic females, providing evidence that sex reversal can be bidirectional in amphibians. While endocrine disrupting chemical contamination is known from laboratory experiments to cause sex reversal in amphibians, sex reversal in green frogs occurs irrespective of contamination, suggesting sex reversal is a natural process in amphibians Sex in reptiles can be determined genetically (GSD), environmentally (ESD) or by an interaction of both. has been documented in detail in wild populations of the central bearded dragon "Pogona vitticeps," and in the eastern three-lined skink "Bassiana duperreyi." In these species, their genetically determined sex is overridden by temperature influence. in reptiles can be induced by hormonal manipulation, treatments influencing sex determination (e.g. temperature) or by inhibition of the aromatase gene (CYP19A1) which causes sex reversal from female to male phenotype. In birds, sex reversal has been documented in natural and experimental conditions | Natural_sciences | https://en.wikipedia.org/wiki?curid=38053611 | Sex reversal | [
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Sex reversal Sex steroid manipulation can induced sex reversal in birds. Aromatase inhibitors injected into chicken eggs before the gonadal differentiation stage induce testis development in ZW embryos. in mammals has been documented in domestic species such as cattle, water buffalo, horses, dogs, cats, pigs, goats, etc. in these species usually relates to genetic changes and the resulting phenotype is often associated with gonadal malformation. Natural sex reversal without disruptive effects on fertility has been documented in several rodents, including "Myopus schisticolor, Dicrostonyx torquatus, Akodon, Mus minutoides, Microtus cabrerae." In these species some individuals genetically determined as males develop typical ovarian structure. In these rodents species, sex reversal mainly occurs after mutational events. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38053611 | Sex reversal | [
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Arwen Colles is an area of small hills on Titan, the largest moon of the planet Saturn. The hills are located near Titan's equator at within the Belet region. is named after Arwen Undómiel, an Elvish princess in J. R. R. Tolkien's fictional world of Middle Earth who appears most prominently in "The Lord of the Rings". The name follows a convention that Titanean colles (hills or small knobs) are named after characters in Tolkien's work. It was formally announced on December 19, 2012. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38061643 | Arwen Colles | [
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Bilbo Colles is an area of small hills on Titan, the largest moon of the planet Saturn. The hills are located near Titan's equator at on western edge of bright region Quivira. is named after Bilbo Baggins, a hobbit in J. R. R. Tolkien's fictional world of Middle Earth who appears most prominently in "The Hobbit". The name follows a convention that Titanean colles (hills or small knobs) are named after characters in Tolkien's work. The name was formally announced on December 19, 2012. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38061687 | Bilbo Colles | [
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Faramir Colles is an area of small hills on Titan, the largest moon of the planet Saturn. The hills are located near Titan's equator at 4° north and 153° east within the Shangri-La region. is named after Faramir, a Gondorian prince in J. R. R. Tolkien's fictional world of Middle Earth who appears most prominently in "The Lord of the Rings". The name follows a convention that Titanean colles (hills or small knobs) are named after characters in Tolkien's work. The name was formally announced on December 19, 2012. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38061717 | Faramir Colles | [
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Karl Rebane Karl K. Rebane (11 April 1926, in Pärnu – 4 November 2007, in Pärnu) was an Estonian physicist. He studied at the Tallinn Technical University from 1947 to 1949, and graduated from Leningrad University in 1952. Rebane received a PhD in Solid State Theory in 1955 from the Leningrad (St. Petersburg) University and a Doctor of Science degree in Theoretical Physics in 1964 from the Institute of Physics of the Belarusian AS at Minsk. He joined Tartu University in 1955 where he held both teaching and administrative positions, including Professor and Chair of the Experimental Physics Department (1958–60), and Professor and Chair of the Joint Department of Laser Optics at the Institute of Physics and Tartu University (1974–1993). He was president of the Estonian Academy of Sciences from 1973 to 1990. He was married to Ljubov Rebane, and had two children, Inna and Aleksander Rebane. He also had three brothers, Jaan, Toomas, and Jüri Rebane. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38069126 | Karl Rebane | [
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WISE 1639−6847 WISE J163940.83−684738.6 (designation is abbreviated to WISE 1639−6847, or W1639) is a brown dwarf of spectral class Y0-Y0.5, located in constellation Triangulum Australe (it's the nearest star / brown dwarf in this constellation) at approximately 16 light-years from Earth. was discovered in 2012 by C. G. Tinney "et al." from data, collected by Wide-field Infrared Survey Explorer (WISE) Earth-orbiting satellite — NASA infrared-wavelength 40 cm (16 in) space telescope, which mission lasted from December 2009 to February 2011. In 2012 Tinney "et al." carried out follow-up observations of using the FourStar infrared mosaic camera mounted on the 6.5 m Magellan Baade telescope at Las Campanas Observatory, Chile (on 2012 May 10–11 (UT)); and spectroscopy using the Folded-port Infrared Echellette (FIRE) also mounted on the 6.5 m Magellan Baade telescope (on 2012 July 10 (UT)). In 2012 Tinney "et al." published a paper in "The Astrophysical Journal", where they presented discovery of a newfound by WISE Y-type brown dwarf (the only brown dwarf discovery, presented in the article): the paper was accepted for publication on 20 September 2012, submitted to arXiv on 27 September 2012, and published in November 2012. has absolute magnitude in "J"-band 22.14 ± 0.22. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38074454 | WISE 1639−6847 | [
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Ljubov Rebane Ljubov A. Rebane (née Chagalova) (September 6, 1929 Leningrad – June 13, 1991 Tallinn) was an Estonian physicist. She graduated from Leningrad University in 1952 and received a PhD in Physics and Mathematics in 1961 from the same University. She received the USSR State Prize (Russian: Госуда́рственная пре́мия СССР) in 1986, together with Rein Avarmaa, Anšel Gorohhovski, Roman Personov, Boris Harlamov, Jevgeni Alšits, Ljudmila Bõkovskaja, Vladimir Maslov, Jaak Kikas and Konstantin Solovjov, for the cycle of articles "High-spectral-resolution spectroscopy and for the persistent spectral hole-burning of molecules and solids" (Russian: Авармаа, Рейн Арнольдович, зав. сектором, Гороховский, Аншель Александрович, Кикас, Яак Вернерович, ст. н. с., Альшиц, Евгений Иосифович, Быковская, Людмила Анатольевна, мл. н. с. Института физики АН ЭССР; Маслов, Владимир Григорьевич, ст. н. с. ГОИ имени С. И. Вавилова; Ребане, Любовь Александровна, ст. н. с. ИХБФАН ЭССР; Соловьёв, Константин Николаевич, зав. лабораторией Института физики АН БССР, — за цикл работ «Фотовыжигание стабильных спектральных провалов и гелективная спектроскопия сложных молекул» (1972—1984)). She married the physicist Karl Rebane. Their children Aleksander and Inna Rebane both became physicists themselves. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38079625 | Ljubov Rebane | [
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North Pennine Batholith The North Pennine Batholith, also known as the Weardale Granite is a granitic batholith lying under northeast England, emplaced around 400 million years ago in the early Devonian. The batholith consists of five plutons, the Tynehead, Scordale, Rowlands Gill, Cornsay and Weardale plutons. The Weardale Granite pluton is the largest and the only one that has been proved (sampled), after the Rookhope Borehole confirmed Martin Bott's hypothesis that a large negative gravity anomaly under Weardale represented a low-density igneous intrusion. In 1934, Kingsley Dunham published a paper proposing that ore deposits in the Alston Block were formed due to a granite intrusion beneath Weardale. This was later tested by a gravity survey, which found a large negative gravity anomaly, supporting the hypothesis. In the early 1960s, a borehole was drilled at Rookhope by Durham University, and proved the existence of the intrusion at a depth of 390 m. The intrusion was found to have a weathered top, so couldn't account for the mineralisation that was the basis of the hypothesis that first suggested its existence. In 2004, a second borehole was drilled in Eastgate, and the granite was reached at 270 m below the surface | Natural_sciences | https://en.wikipedia.org/wiki?curid=38125730 | North Pennine Batholith | [
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] |
Born equation The can be used for estimating the electrostatic component of Gibbs free energy of solvation of an ion. It is an electrostatic model that treats the solvent as a continuous dielectric medium (it is thus one member of a class of methods known as continuum solvation methods). It was derived by Max Born. where: aspects about this equation | Natural_sciences | https://en.wikipedia.org/wiki?curid=38128880 | Born equation | [
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Johann Frederik Eijkman Johan Fredrik Eykman or (19 January 1851 – 7 January 1915) was a Dutch chemist. He is one of the eight children of Christiaan Eijkman, the headmaster of a local school, and Johanna Alida Pool. His brother Christiaan Eijkman (1858–1930) was a physician and professor of physiology whose demonstration that beriberi is caused by poor diet led to the discovery of vitamins. Together with Sir Frederick Hopkins, his brother received the Nobel Prize for Physiology or Medicine. He was hired during the Meiji period, a Japanese era which extended from September 1868 through July 1912. During his stay in Japan, he was the first to isolate shikimic acid in 1885 from the Japanese flower shikimi (シキミ, the Japanese star anise, "Illicium anisatum"). | Natural_sciences | https://en.wikipedia.org/wiki?curid=38130154 | Johann Frederik Eijkman | [
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Mordin Solus is a fictional character in BioWare's "Mass Effect" franchise, who serves as a party member (or "squadmate") in "Mass Effect 2". A salarian (one of "Mass Effect"s alien races) physician and life scientist, Mordin strengthened a weakening artificial sterility plague, named the genophage, used against the krogan—a fast-breeding warlike alien race. Fast-talking and affable, Mordin is guided by scientific principles and logic rather than morals. He returns in "Mass Effect 3", where he has developed a cure for the genophage and intends to distribute it in the atmosphere of Tuchanka, the krogan homeworld. The character is also featured in the ninth issue of "Mass Effect: Foundation", which explores his creation of and the distribution of the strengthened genophage. Mordin is voiced by Michael Beattie in "2" and William Salyers in "3", and was written by Patrick Weekes. His race was conceived as a variant of the gray alien archetype, while the character is designed with clothes that hint towards a labcoat. Inspiration for his face was taken from Clint Eastwood. David Kates composed his musical theme, a highly electronic piece in comparison to some of "2"s more orchestral pieces. The character has been positively received, being nominated for three "Best New Character" awards and earning numerous placements in "top character" lists. In addition, 1UP.com ran an article focusing on how Mordin was "awesome" | Natural_sciences | https://en.wikipedia.org/wiki?curid=38135215 | Mordin Solus | [
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Mordin Solus At one point in the second game, Mordin sings an alternate version of Gilbert and Sullivan's Major-General's Song; numerous critics considered it one of the trilogy's best moments. As with other "Mass Effect" squadmates, merchandise for Mordin has been made, such as a bust. Mordin is a male salarian, nearing the end of a salarian's lifespan. The salarians are warm-blooded amphibians with a hyperactive metabolism, and are known for their relatively short lifespans compared to other races in the galactic community. Salarians are generally known for their observational capability and non-linear thinking, which manifests as an aptitude for research and espionage. He is described as being "guided by scientific principles rather than morals", willing to do what is necessary for the greater good, though nevertheless eccentric. David Kates, creator of his musical theme, believed him to add a little comic relief to the game, calling him "quirky, a little bit disorganized, definitely cerebral, overthinking". However, at the same time he noted Mordin's hard-edge side, something he found fascinating about the character. A brilliant scientist, Mordin is said to have previously worked for the Special Tasks Group (STG), a salarian espionage organisation. While working for them, he modified the genophage, a virus that almost sterilised the krogan (another alien race), after it was revealed the krogan were naturally overcoming it | Natural_sciences | https://en.wikipedia.org/wiki?curid=38135215 | Mordin Solus | [
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Mordin Solus Despite holding some regrets over doing so, working on the genophage proved intellectually challenging, and he believes if he hadn't done it, someone less skilled might have—risking completely sterilizing the krogan by accident. Mordin's race, the salarians, are intended to be a take on the gray alien archetype. Due to his relative old age, Mordin allowed the developers to explore the later lifestages of its aliens. The vocal specifications, given to auditioners, wanted someone able to be both dramatic and comedic, referencing Marshall Flinkman of "Alias". The character was voiced by Michael Beattie in "Mass Effect 2", though was replaced with William Salyers for "3". Ginny McSwain served as the voice director. Initially, Beattie tried a higher-pitched voice, but as all the salarians were pitched-up he ultimately used something more like his natural voice. After being replaced, Beattie wrote an open letter thanking fans who had vied for his return. Beattie has said he would be interested in reprising the character, whether it be in a movie adaptation or a future game. Patrick Weekes wrote the character. When first handed the character's description, the scientist who strengthened the genophage, Weekes' initial reaction was "unrecordable, but translated roughly as 'that jerk, him being a fan of the first game's krogan squadmate Wrex | Natural_sciences | https://en.wikipedia.org/wiki?curid=38135215 | Mordin Solus | [
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Mordin Solus Weekes saw two ways to take the character: either have him as an unlikeable "war criminal", or challenge himself to make a character who believed he had made the hard choice and did the right thing. Mordin's final scene on Tuchanka in the third game, and its variations, was influenced by both Weekes and fellow senior writer John Dombrow, who wrote the genophage arc in the game. Weekes wished to give Mordin a "good send-off" in the scene. Each squadmate in "Mass Effect 2" had music composed for them, intended to convey their character; BioWare gave the composers detailed character studies for each to help. Mordin's theme was composed by David Kates, who also worked on themes for other characters like Garrus. Kates had previously worked on the soundtrack for the first game. He considered Mordin's level one of the most fascinating to do, and it is one of the more electronic pieces. The composition contained many counterpoint elements, as well as "early retro synthesizer qualities". When creating the salarians, early on the designers played around with the general image of the gray alien archetype, having big eyes and grey skin. However, unlike regular gray aliens, salarians ended up with a concave torso and "doglike" legs. Different concepts of salarians were drawn, though many were rejected for being too human-looking. Unlike some of the other races, the salarians are more of "warrior poets" and have a higher sense of culture. The heavy eyelids and long face add more sophistication | Natural_sciences | https://en.wikipedia.org/wiki?curid=38135215 | Mordin Solus | [
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Mordin Solus Their big black eyes express "tranquility" and "alertness". The concave chest is a more alien, unusual structure, and differed from some of the other races. This structure also led to stylistic choices with their clothing, under the idea that they'd stuff fabric there after meeting other races, which art director Matt Rhodes compared to "a bald man wearing a toupée". Mordin's design specifically tried to balance his scientific side and his ability as a combat-ready tech specialist due to time in the salarian special forces. His final appearance resembles a labcoat, and is similar to other medical characters in the series. The metal collar serves to break up his silhouette, though serves no purpose in dialogue or lore. Early sketches explored him as a field medic or very experienced scientist. Other early concepts tried altering his head horns and eyeshape to make him unique. In his finished design, Mordin is missing one horn, unexplained with its origins left to the player's imagination. The missing horn is given alternate in-universe explanations in the second game's "Lair of the Shadow Broker" downloadable content pack and in the "Mass Effect: Foundation" comic series. The design brief for Mordin essentially asked "What would the Clint Eastwood salarian look like?", and to that end one piece of concept art directly took features from a picture of Eastwood and incorporated them on a salarian, leading to Mordin's aged look | Natural_sciences | https://en.wikipedia.org/wiki?curid=38135215 | Mordin Solus | [
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Mordin Solus Compared to other salarians, Mordin's skin color is more mottled and multi-colored, while his eyes are smaller, almost as if in a permanent squint. debuts in 2010's "Mass Effect 2". Commander Shepard, the player character and protagonist of the game, goes to Omega to recruit him as a tech specialist for an assault on the Collector base. Shepard finds him running a clinic and distributing the cure for a currently rampant plague in a sealed-off district of the station. Mordin asks Shepard to reactivate the district's environmental systems, and distribute the cure through them. After this is done, Mordin joins the party and can be talked to aboard the "Normandy", Shepard's spaceship, and brought along for future missions. Each squadmate in "Mass Effect 2" has an optional "loyalty mission". Mordin informs Shepard that his old assistant, Maelon, has been captured by krogan on Tuchanka. During the mission, which takes place in a hospital, Mordin discovers horrific tests by krogan trying to cure the genophage, and the player may have Shepard confront him about his work on it. Eventually, Mordin finds Maelon, who is revealed to have voluntarily joined the krogan due to guilt over helping develop the genophage. Horrified by the brutality of the tests, Mordin may kill Maelon depending on the player's actions. Mordin then discovers Maelon has found valuable data that could prove useful to curing the genophage, and the player can choose whether to destroy it or save it | Natural_sciences | https://en.wikipedia.org/wiki?curid=38135215 | Mordin Solus | [
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Mordin Solus Like every other squadmate, it is possible for Mordin to die during the final mission of the game—the "Suicide Mission"—depending on the player's choices. His chances of dying increase if the player does not complete his loyalty mission. As a scientist, Mordin uses technology abilities in battle, particularly Incinerate and Cryo Blast, which respectively tear through armor and snap freeze enemies. He is armed with a submachine gun and a pistol. However, as he is just a scientist, he is the weakest of all the squad members, with the game's algorithm written to kill Mordin first during the suicide mission's final act should the team's defensive capabilities not be strong enough. Mordin was first confirmed to be appearing in 2012's "Mass Effect 3" during Microsoft's E3 2011 conference, in June. Unless the player imports a save where Mordin died in "Mass Effect 2", Mordin will appear on Sur'Kesh, where Shepard arrives seeking the cure for the genophage to secure an alliance with the krogan. Mordin reveals he is the krogan's informant about the cure, which may be extracted from a cured female (whom Mordin names Eve, after the biblical figure). Mordin comes aboard the Normandy and works on the cure, and can be talked to though is not available as a squadmate. On Tuchanka, Mordin finishes the cure and gets ready to plant it in the Shroud, a salarian construct used to alter the atmosphere of the planet | Natural_sciences | https://en.wikipedia.org/wiki?curid=38135215 | Mordin Solus | [
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Mordin Solus If the player has not already chosen to notify him of it, Mordin will notice salarian sabotage in the Shroud, designed to stop any cure being distributed through it. Depending on the player's choices thus far, they can choose between: letting Mordin go up to fix the sabotage and cure the genophage, at the cost of his life; shooting Mordin to prevent the genophage being cured (while giving the illusion that it was), ensuring salarian support; or convincing Mordin that now is not the right time to cure the genophage, causing him to back down and go into hiding (to fake his death and thus fake the dispersing of the cure). If Mordin survives the game, he will available to talk via holocommunication before the final mission. If a save is imported where Mordin died during the Suicide Mission, his role in the game will be replaced by another salarian named Padok Wiks. The ninth issue of the "Foundation" comic series, published March 2014, focuses on Mordin's creation of the modified genophage prior to the games' events. Mordin is introduced talking with other high-level salarians about the weakening genophage; they agree to Mordin's proposal of strengthening it. Mordin researches and develops the new genophage strain in less than a week, and a month later he and other STG members go to Tuchanka to test it on a krogan colony. The intended deployment site turns out to be occupied by a krogan gathering led by a female rather than being empty, and the krogan notice the STG team and fire upon them | Natural_sciences | https://en.wikipedia.org/wiki?curid=38135215 | Mordin Solus | [
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Mordin Solus The team retreat back to the shuttle, and after the captain volunteers himself as a diversion, Mordin comes up with an alternate plan of planting explosives in a tunnel as a diversion instead while he and his assistant arm the dispersion unit at the original intended site. The female krogan from earlier is waiting there, and Mordin confronts her while his assistant arms the unit. As they talk, Mordin's explosions go off. The female is killed, while Mordin is rescued by the captain. The assistant begins to doubt if they're doing the right thing, but Mordin remains firm in his beliefs that the krogan are a threat if left unchecked. Like other squadmates in the trilogy, Mordin was the subject of different merchandise. Figures for the characters were announced in January 2010, with Mordin and three others being announced for the second set. They were later announced to be releasing concurrently with "Mass Effect 3", in March 2012, coming with free in-game content. An eight-inch tall bust of the character was made available in the BioWare store. Dark Horse released a set of "Mass Effect" playing cards, featuring Mordin as the King of Diamonds and other characters in other roles. Mordin has been positively received. "1UP.com's" Jose Otero wrote an article dedicated to why Mordin was "awesome", saying he "epitomize[d] the coolest nerd in the ME universe: a mysterious, strong-willed, and scarred little scientist who delivers dialogue in quick, direct doses" | Natural_sciences | https://en.wikipedia.org/wiki?curid=38135215 | Mordin Solus | [
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Mordin Solus "GamesRadar", in a piece comparing different voice actors playing the same characters, commented that they could not tell the difference between the two performers. After hearing of a possible future "Mass Effect" film, "Game Informer"s Dan Ryckert looked at the different characters and felt David Hyde Pierce would be their ideal casting choice. Tom Phillips of "Eurogamer" called him one of the most complex characters, and noted how he represented one of the series' "greyest" plotlines. He was nominated for various awards: by IGN as the best Xbox 360 character of 2010 (losing to fellow "ME2" squadmate Thane Krios though winning the "Reader's Choice" version), best new character of 2010 by GameSpot, and by Giant Bomb in their "Game of the Year 2010" best new character award (which he tied first-place with Bayonetta). Since his appearance in "Mass Effect 2", the character has been featured in different "top" lists. "Game Informer"s Kimberley Wallace considered him to be one of the best BioWare characters, calling him lovable and citing "his friendly demeanor and tendency to break into song". IGN listed him as the tenth best "Mass Effect" squadmate, calling him polarizing and fascinating. "Maximum PC" called him one of the 25 best sidekicks in gaming, highlighting the moment where he can give Shepard pointers on safe-sex and interspecies romance | Natural_sciences | https://en.wikipedia.org/wiki?curid=38135215 | Mordin Solus | [
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Mordin Solus "GamesRadar" placed him at number 16 in a list of the 50 best game characters of the generation, describing him as "one of the most distinct, personable crew members to ever set foot on the Normandy". A reader's poll published by "PC Gamer" in 2015 reveal that Mordin was overall the third most popular "Mass Effect" character. In a 2016 article, "PC Gamer" ranked Mordin the second best companion of the "Mass Effect" series. "PC Gamer" staff member Tom Senior said he loves Mordin "because he shows that you don't need stubble, a gravelly voice and a thousand yard stare to be an anti-hero". "Green Man Gaming" included Mordin in their top 5 list of the best characters from the "Mass Effect" franchise. His singing of Gilbert and Sullivan was highlighted. "Kotaku's" Mike Fahey listed it as one of their favourite gaming moments of 2010, while Gergo Vas (also of "Kotaku") called it one of the most iconic moments in the trilogy. It was similarly liked by Martin Gaston of VideoGamer.com, who listed "Mordin singing" as one of the things they'd like to see in the then-upcoming third game. Both IGN's Destin Legarie and the staff of VideoGamer.com included it in lists of "Mass Effect"s top moments. John Newby from "Gamesradar" was inspired by Mordin's singing and included the character in his list of 12 video game characters who would make great teachers | Natural_sciences | https://en.wikipedia.org/wiki?curid=38135215 | Mordin Solus | [
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Mordin Solus Another positively received moment was his potential sacrificial death scene in "Mass Effect 3", also included by Legarie in his top 13 "Mass Effect" moments, commenting "Watching a fan favorite die was difficult for many, and we're willing to bet it brought a tear to an eye or two." "Green Man Gaming" commented on his death scene, "If you don’t cry, you’re broken. Sorry, that’s just how it is". The death scene won "Best Moment" in "Game Informer"s 2012 RPG of the Year Awards. Vas included his "curtain call" also on his "most iconic moments of the "Mass Effect" trilogy" list. One of Mordin's quotes: "Hard to see big picture behind pile of corpses.", was selected by "Gamesradar" as one of the best video game quotes of all time. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38135215 | Mordin Solus | [
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Anna Volkova Anna Feodorovna Volkova (, d. 1876), was a Russian chemist working predominantly with amides. During the late 1860s, she was educated in chemistry through public lectures at St. Petersburg University. She was the first woman to graduate as a chemist (1870), the first woman member of the Russian Chemical Society, the first Russian woman to publish a chemical work, and regarded as the first woman at all to publish her own chemical research from a modern chemical laboratory. From 1869, she worked in the laboratory of Alexander Nikolayevich Engelhardt. She led practical courses for female students in St. Petersburg under the tutelage of Dmitri Mendeleev. In 1870, she was the first chemist to prepare pure orthotoluenesulfonic acid and its acid chloride and amide. She was also the first to prepare paratricresol phosphate, a component of a now-important plasticizer, from para-cresol. One of the craters of Venus is named after her. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38135607 | Anna Volkova | [
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Nadezhda Ziber-Shumova Nadezhda Olimpievna Ziber-Shumova (Russian Надежда Олимпиевна Зибер-Шумова; also Nadine, Nadina, Natalja, N., Sieber, Siber, Ziber-Šumova; born 18 May 1854 or 7 May 1856 in Samara, Russian Empire – died 16 May 1916/17) was a Russian physician and chemist. She was co-founder of the Imperial Institute of Experimental Medicine in St. Petersburg, where she was head of the department of chemistry and biochemistry. She was informally educated in chemistry in Switzerland, where she moved with her spouse, the Marxist Nikolai Ziber in 1872. From 1877, she was active as a scientist, and are regarded to have published more scientific chemistry works than any other woman before 1900. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38136679 | Nadezhda Ziber-Shumova | [
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Sachin Anil Punekar is an Indian botanist and ornithologist and founder President of Biospheres, a non-government organisation working for conservation of biodiversity. He has so far described more than 20 new plant taxa to the science. He did his PhD on 'Flora of Anshi National Park, Karnataka State' from Botanical Survey of India. He is working at Agharkar Research Institute, Pune. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38145512 | Sachin Anil Punekar | [
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World Checklist of Selected Plant Families The (usually abbreviated to WCSP) is an "international collaborative programme that provides the latest peer reviewed and published opinions on the accepted scientific names and synonyms of selected plant families." Maintained by the Royal Botanic Gardens, Kew, it is available online, allowing searches for the names of families, genera and species, as well as the ability to create checklists. The project traces its history to work done in the 1990s by Kew researcher Rafaël Govaerts on a checklist of the genus "Quercus". Influenced by the Global Strategy for Plant Conservation, the project expanded. , 173 families of seed plants were included. Coverage of monocotyledon families is complete; other families are being added. There is a complementary project called the International Plant Names Index (IPNI), in which Kew is also involved. The IPNI aims to provide details of publication and does not aim to determine which are accepted species names. After a delay of about a year, newly published names are automatically added from the IPNI to the WCSP. The WCSP is also one of the underlying databases for The Plant List, created by Kew and the Missouri Botanical Garden, which was unveiled in 2010. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38145616 | World Checklist of Selected Plant Families | [
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Karel Cejp (22 February 1900 – 22 September 1979) was a Czech botanist and mycologist. After finishing highschool (rokycanském gymnáziu), he worked with Bohuslav Horak, an expert in the flora of the Balkan Peninsula and the Mediterranean. Later, he studied at Charles University in Prague with Josef Velenovský. In 1933 he was appointed an associate professorship, and in 1948 became a full professor. Cejp became the editor of the mycological journal "Czech Mycology" in 1948. Fungal taxa named in his honour include "Cejpia", "Cejpomyces" (now "Thanatephorus"), and Cejpomycetaceae (since subsumed in Ceratobasidiaceae). | Natural_sciences | https://en.wikipedia.org/wiki?curid=38163660 | Karel Cejp | [
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SEVENDIP SEVENDIP, which stands for Search for Extraterrestrial Visible Emissions from Nearby Developed Intelligent Populations, was a project developed by the Berkeley SETI Research Center at the University of California, Berkeley that used visible wavelengths to search for extraterrestrial life's intelligent signals from outer space. Between 1997 and 2007, employed a 30-inch automated telescope located in Lafayette, California, to scan the sky for potential optical interstellar communications in the nanosecond time-scale laser pulses. Another instrument was mounted on Berkeley's 0.8-meter automated telescope at Leuschner Observatory. Their sensors have a rise time of 0.7 ns and are sensitive to 300 - 700 nm wavelengths. The target list included mostly nearby F, G, K and M stars, plus a few globular clusters and galaxies. The Leuschner pulse search examined several thousand stars, each for approximately one minute or more. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38179259 | SEVENDIP | [
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NGC 6850 is a spiral galaxy in the constellation Telescopium, discovered by John Herschel in 1836. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38186905 | NGC 6850 | [
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NGC 5477 is a dwarf galaxy located in the constellation of Ursa Major, 20 million light years away from Earth. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38195771 | NGC 5477 | [
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A History of British Birds is a natural history book by Thomas Bewick, published in two volumes. Volume 1, Land Birds, appeared in 1797. Volume 2, Water Birds, appeared in 1804. A supplement was published in 1821. The text in "Land Birds" was written by Ralph Beilby, while Bewick took over the text for the second volume. The book is admired mainly for the beauty and clarity of Bewick's wood-engravings, which are widely considered his finest work, and among the finest in that medium. "British Birds" has been compared to works of poetry and literature. It plays a recurring role in Charlotte Brontë's novel "Jane Eyre". William Wordsworth praised Bewick in the first lines of his poem "The Two Thieves": "Oh now that the genius of Bewick were mine, And the skill which he learned on the banks of the Tyne." The book was effectively the first "field guide" for non-specialists. Bewick provides an accurate illustration of each species, from life if possible, or from skins. The common and scientific name(s) are listed, citing the naming authorities. The bird is described, with its distribution and behaviour, often with extensive quotations from printed sources or correspondents. Those who provided skins or information are acknowledged. The species are grouped into families such as "Of the Falcon", using the limited and conflicting scientific sources of the time | Natural_sciences | https://en.wikipedia.org/wiki?curid=38205844 | A History of British Birds | [
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] |
A History of British Birds The families of land birds are further grouped into birds of prey, omnivorous birds, insectivorous birds, and granivorous birds, while the families of water birds are simply listed, with related families side by side. Each species entry begins on a new page; any spaces at the ends of entries are filled with tail-pieces, small, often humorous woodcuts of country life. "British Birds" remains in print, and has attracted the attention of authors such as Jenny Uglow. Critics note Bewick's skill as a naturalist as well as an engraver. The preface states that "while one of the editors of this work was engaged in preparing the cuts, which are faithfully drawn from Nature, and engraved upon wood, the compilation of the descriptions .. "(of the Land Birds)" was undertaken by the other , subject, however, to the corrections of his friend, whose habits had led him to a more intimate acquaintance with this branch of Natural History", and goes on to mention that the compilation of text was the "production of those hours which could be spared from a laborious employment", namely the long hours of work engraving the minutely detailed wood printing blocks. What the preface does not say is the reason for this statement about the "editors", which was an angry stand-off between Bewick and Beilby, caused by Beilby's intention to have an introduction which merely thanked Bewick for his "assistance", and a title page naming Beilby as the sole author | Natural_sciences | https://en.wikipedia.org/wiki?curid=38205844 | A History of British Birds | [
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] |
A History of British Birds Bewick's friend (and his wife's godfather) Thomas Hornby heard of this, and informed Bewick. An informal trade panel met to judge the matter, and the preface was the result; and Beilby's name did not appear on the title page. Each species of bird is presented in a few pages (generally between two and four; occasionally, as with the mallard or "Common Wild Duck", a few more). First is a woodcut of the bird, always either perched or standing on the ground, even in the case of water birds – such as the smew – that (as winter visitors) do not nest in Britain, and consequently are rarely seen away from water there. Bewick then presents the name, with variations, and the Latin and French equivalents. For example, "The Musk Duck" is also named on the line below as "Cairo, Guinea, or Indian Duck", and the next line "("Anas moschata", Linn.—"Le Canard Musque", Buff.)" provides the scholarly references to the giving of the Latin binomial by Linn[aeus] and a French description by Buff[on]. The text begins by stating the size of the bird. Bewick then describes the bird, typically in one paragraph, naming any notable features such as the colour of the eyes ("irides"), the bill, the legs, and plumage on each part of the body. Next, the origin and distribution of the species are discussed, with notes or quotations from authorities such as John Ray, Gilbert White and Buffon | Natural_sciences | https://en.wikipedia.org/wiki?curid=38205844 | A History of British Birds | [
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] |
A History of British Birds Bewick then mentions any other facts of interest about the bird; in the case of the musk duck, this concerns its "musky smell, which arises from the liquor secreted in the glands on the rump". If the bird hybridizes with other species, this is described, along with whether the hybrids are fertile ("productive"). Finally, Bewick acknowledges anyone who helped. The musk duck is stated to have been drawn from a "living specimen" which was however "excepting the head, entirely white", unlike the "general appearance" shown in the woodcut; the bird "was lent to this work by William Losh, Esq., of Point Pleasant, near Newcastle". Losh, one of Bewick's many collaborators, was a wealthy partner in Losh, Wilson and Bell, manufacturers of chemicals and iron. Many of the birds, especially the rarer species, were necessarily illustrated from skins rather than from life. For example, for the Sabine's snipe, "The author was favoured by N. A. Vigors, Esq., [who had described the supposed species] with a preserved specimen, from which the above figure is taken." In "A Memoir" (posthumously published in 1862), Bewick states that he intended to "stick to nature as closely as I could", but admits that he had "in several cases" to rely on the stuffed "preserved skins" of his neighbour Richard Routledge Wingate. The grouping of species gave Bewick difficulty, as the scientific sources of the time did not agree on how to arrange the species in families, or on a sequence or grouping of those families | Natural_sciences | https://en.wikipedia.org/wiki?curid=38205844 | A History of British Birds | [
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A History of British Birds Bewick for example uses family groups like "Of the Falcon", in which he includes buzzards and sparrowhawks as well as what are now called falcons. The families of land birds are further grouped into birds of prey, omnivorous birds, insectivorous birds, and granivorous birds, while the families of water birds are simply listed, with what seemed to be related families, such as "Of the Anas" (ducks) and "Of the Mergus" (sawbill ducks), side by side. In this way the book takes the form of, and sets a precedent for, modern field guides. Indeed, the French naturalist (1753–1830) assembled a field guide using Bewick's woodcuts as early as 1800. Each account is closed with a miniature woodcut known from its position in the text as a tail-piece. These small artworks depict aspects of country life, often with humorous subjects, but all with Bewick's eye for detail, style, and precision. Some add to the illustration of the bird in question, as for example the heron, where the tail-piece shows one heron catching an eel, and another flying away. The tail-piece for Sabine's snipe, a gamebird, shows a hunter firing, and a small bird falling to the ground. There is no exclusion of human life from the images: one tail-piece depicts a works complete with smoking chimney beside a river. The first volume "containing the History and Description of Land Birds" begins with a preface, an introduction, and a list of technical terms illustrated with Bewick's woodcuts | Natural_sciences | https://en.wikipedia.org/wiki?curid=38205844 | A History of British Birds | [
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A History of British Birds The introduction begins: In no part of the animal creation are the wisdom, the goodness, and the bounty of Providence displayed in a more lively manner than in the structure, formation, and various endowments of the feathered tribes. The birds are divided into granivorous (grain eating) and carnivorous groups, which are explained in some detail. The speed, senses, flight, migration, pairing behaviour and feeding of birds are then discussed, with observations from Spallanzani and Gilbert White, whose "Natural History and Antiquities of Selborne" was published in 1789. The pleasure of watching birds is mentioned: To the practical ornithologist there arises a considerable gratification in being able to ascertain the distinguishing characters of birds as they appear at a distance, whether at rest, or during their flight; for not only every genus has something peculiar to itself, but each species has its own appropriate marks, by which a judicious observer may discriminate almost with certainty. Bewick also mentions conservation, in the context of the probable local extinction of a valuable resource: "Both this and the Great Bustard are excellent eating, and would well repay the trouble of domestication; indeed, it seems surprising, that we should suffer these fine birds to be in danger of total extinction, although, if properly cultivated, they might afford as excellent a repast as our own domestic poultry, or even as the Turkey, for which we are indebted to distant countries | Natural_sciences | https://en.wikipedia.org/wiki?curid=38205844 | A History of British Birds | [
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A History of British Birds " The 1847 edition, revised with additional woodcuts and descriptions, is organized as follows, with the species grouped into families such as the shrikes: The second volume "containing the History and Description of Water Birds" begins with its own preface, and its own introduction. Bewick discusses the question of where many seabirds go to breed, revisits the subject of migration, and concludes with reflections on "an all-wise Providence" as shown in Nature. The 1847 edition is organized as follows: The 'foreign birds' are not grouped but just listed directly as species, from Bearded Vulture to Mino. Fifteen birds are included, with no description, and despite their placement in the table of contents, they appear at the front of the volume as an 'Appendix'. In 1805, the "British Critic" wrote that it was "superfluous to expatiate much on the merits of a work" that everyone liked because of "the aptness of its descriptions, the accuracy of its figures, the spirit of its wood engravings, and the ingenious variety of its vignettes." The 1829 "Magazine of Natural History" commented that "Montagu's "Ornithological Dictionary" and Bewick's "Birds" .. have rendered [the] department of natural history popular throughout the land" | Natural_sciences | https://en.wikipedia.org/wiki?curid=38205844 | A History of British Birds | [
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A History of British Birds "Ibis", reviewing the "Memoir of Thomas Bewick, written by himself" in 1862, compares the effect of Bewick and Gilbert White, writing "It was the pages of Gilbert White and the woodcuts of Bewick which first beguiled the English schoolboy to the observation of our feathered friends", and "how few of our living naturalists but must gratefully acknowledge their early debt to White's 'History' and to the life-like woodcuts of Bewick!" The reviewer judges that "Probably we shall not wrong the cultivated annalist of Selborne by giving the first place to Bewick." However, comparing them as people, "Bewick has not the slightest claim to rank with Gilbert White as a naturalist. White was what Bewick never was, a man of science; but, if no naturalist, Bewick was a lover of nature, a careful observer, and a faithful copier of her ever-varying forms. In this, and in this alone, lies his charm." The "1911 Encyclopædia Britannica"s entry on Thomas Bewick describes "the "British Birds"" as "his great achievement, that with which his name is inseparably associated", observing that "Bewick, from his intimate knowledge of the habits of animals acquired during his constant excursions into the country, was thoroughly qualified to do justice to this great task | Natural_sciences | https://en.wikipedia.org/wiki?curid=38205844 | A History of British Birds | [
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A History of British Birds " "British Birds", reviewing a "lavishly illustrated" British Library book on Bewick, writes that "No ornithologist will ever regard Thomas Bewick, known primarily for The History of British Birds (1797–1804), as a naturalist of the same standing as contemporaries such as Edward Donovan, John Latham and James Bolton", noting however that Bewick helped to define "a certain English Romantic sensibility". More directly, the review notes that "Bewick was aware that his role was to offer a modest guide to birds that the common man not only could afford but would also want to possess." Bewick was not "a scientist, but he was a perfectionist". The book's text was written by "failed author" Ralph Beilby, but the text is "almost extraneous" given Bewick's masterpiece. The Tate Gallery writes that Bewick's " best illustrations ... are in his natural history books. The History of British Birds (2 vols, Newcastle upon Tyne, 1797–1804) reveals Bewick's gifts as a naturalist as well as an engraver (the artist was responsible for the text as well as the illustrations in the second volume)." The article notes that the book makes "extensive use of narrative tailpieces: vignettes in which manifold aspects of north-country life are expressed with affection, humour and a genuine love of nature. In later years these miniature scenes came to be more highly regarded than the figures they accompany | Natural_sciences | https://en.wikipedia.org/wiki?curid=38205844 | A History of British Birds | [
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A History of British Birds " Dissenting from the general tone of praise for Bewick, Jacob Kainen cites claims that "many of the best tailpieces in the "History of British birds" were drawn by Robert Johnson", and that "the greater number of those contained in the second volume were engraved by Clennell. Granted that the outlook and the engraving style were Bewick's, and that these were notable contributions, the fact that the results were so close to his own points more to an effective method of illustration than to the outpourings of genius." Kainen argues that while competent, Bewick "was no Holbein, no Botticelli—it is absurd to think of him in such terms—but he did develop a fresh method of handling wood engraving." The Linnean Society writes that the "History" "shows that he was also an excellent naturalist, a meticulous observer of birds and animals in their habitats." The University of Maryland writes that "The "Birds" is specific to those species indigenous to Britain and is incredibly accurate due to Bewick's personal knowledge of the habits of birds in the wild acquired during his frequent bird-watching expeditions." It adds that "Bewick's woodcarvings are considered a pinnacle example of the medium." Jenny Uglow, writing in "The Guardian", notes that "An added delight was the way he filled the blank spaces with 'tail-pieces', tiny, witty, vivid scenes of ordinary life | Natural_sciences | https://en.wikipedia.org/wiki?curid=38205844 | A History of British Birds | [
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A History of British Birds " She describes the importance of "Birds" in "Jane Eyre", and ends "He worked with precision and insight, in a way that we associate with poets such as Clare and Wordsworth, Gerard Manley Hopkins and Elizabeth Bishop. To Bewick, nature was the source of joy, challenge and perpetual consolation. In his woodcuts of birds and animals as well as his brilliant tail-pieces, we can still feel this today." However, in her biography of Bewick, she adds that "The country might be beautiful but it also stank: in his vignettes men relieve themselves in hedges and ruins, a woman holds her nose as she walks between the cowpats, and a farmyard privy shows that men are as filthy as the pigs they despise." Hilary Spurling, reviewing Uglow's biography of Bewick in "The Observer", writes that when "Birds" appeared, people all over Britain "became his pupils". Spurling cites Charles Kingsley's story of his father's hunting friends from the New Forest mocking him for buying "a book 'about dicky-birds", until, astonished, they saw the book and discovered "things they had known all their lives and never even noticed". John Brewer, writing in the "London Review of Books", says that for his "Birds", "Bewick had acquired national renown as the artist who most truthfully depicted the flora and fauna of the British countryside." He adds that "Bewick's achievement was both technical and aesthetic." In his view, Bewick "reconciled nature, science and art | Natural_sciences | https://en.wikipedia.org/wiki?curid=38205844 | A History of British Birds | [
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A History of British Birds His engravings of British birds, which represent his work at its finest, are almost all rendered with the precision of the ornithologist: but they also portray the animals in their natural habitat – the grouse shelters in his covert, the green woodpecker perches on a gnarled branch, waders strut by streams ..." He observes that "Most of the best engravings include a figure, incident or building which draws the viewer's eye beyond and behind the animal profile in the foreground. Thus the ploughboy in the distant field pulls our gaze past the yellow wagtail ..." The "History" is repeatedly mentioned in Charlotte Brontë's 1847 novel "Jane Eyre". John Reed throws the "History of British Birds" at Jane when she is ten; Jane uses the book as a place to which to escape, away from the painful Reed household; and Jane also bases her artwork on Bewick's illustrations. Jane and Mr Rochester use bird names for each other, including linnet, dove, skylark, eagle, and falcon. Brontë has Jane Eyre explain and quote Bewick: I returned to my book--Bewick's History of British Birds: the letterpress thereof I cared little for, generally speaking; and yet there were certain introductory pages that, child as I was, I could not pass quite as a blank | Natural_sciences | https://en.wikipedia.org/wiki?curid=38205844 | A History of British Birds | [
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A History of British Birds They were those which treat of the haunts of sea-fowl; of 'the solitary rocks and promontories' by them only inhabited; of the coast of Norway, studded with isles from its southern extremity, the Lindeness, or Naze, to the North Cape-- <poem>Where the Northern Ocean, in vast whirls, Boils round the naked, melancholy isles Of farthest Thule; and the Atlantic surge Pours in among the stormy Hebrides.</poem> The English romantic poet William Wordsworth began his 1800 poem "The Two Thieves; or, the Last Stage of Avarice" with the lines <poem>Oh now that the genius of Bewick were mine And the skill which he learned on the banks of the Tyne. Then the Muses might deal with me just as they chose, For I'd take my last leave both of verse and of prose.</poem> Peter Hall's 1974 film "Akenfield" (from the 1969 book by Ronald Blythe) contains a scene where the grandfather as a young man is reaping a cornfield. He weeps when he accidentally crushes a bird's egg, an image derived from Bewick's tail-piece woodcut for the partridge. The woodcut shows a reaper with a scythe, a dead bird and its nest of a dozen eggs on the ground under the scythe, which has just lifted. George Ewart Evans used the image on the title-page of his 1956 book about Blaxhall (near Charsfield, on which 'Akenfield' is probably partly based). A selection of tail-pieces from the book, where they have no captions. Volume 1 first appeared in 1797, and was reprinted several times in 1797, then again in 1798 and 1800. Volume 1 was priced 13s. in boards | Natural_sciences | https://en.wikipedia.org/wiki?curid=38205844 | A History of British Birds | [
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A History of British Birds Volume 2 first appeared in 1804 (price 11. 4s. in boards). The first imprint was "Newcastle : Printed by Sol. Hodgson, for Beilby & Bewick; London: Sold by them, and G.C. and J. Robinson, 1797–1804." The book was reprinted in 1805, 1809, 1816, and 1817. In 1821 a new edition appeared with supplements to both volumes and additional figures, with the imprint "Printed by Edward Walker, Pilgrim-Street, for T. Bewick: sold by him, and E. Charnley, Newcastle; and Longman and co., London, 1821." The book was reprinted in many subsequent versions with a 6th edition in 1826, another in 1832, an 8th edition in 1847, and a royal octavo 'Memorial Edition' in 1885. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38205844 | A History of British Birds | [
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Hermanus Haga Herman Haga (Oldeboorn, 24 January 1852 – Zeist, 11 September 1936) was a Dutch physicist. Haga studied physics from 1871 to 1876 at the University of Leiden. He received his PhD with thesis "Over de absorptie van stralende warmte door waterdamp" (On the absorption of radiant heat by water vapor) under the direction of Pieter L. Rijke. From 1886 to 1921 Haga was professor of physics at the University of Groningen, where he designed and oversaw the building of a new physics laboratory, opened in 1892. From 1900 Haga was also the rector of the University of Gronigen. He performed experiments on the voltage of the Weston cell; these experiments lead to the modern definition of the volt. With Cornelis Wind, Haga passed X-rays through a 15-micrometer slit as a source with a V-shaped narrowing slit as a target. The target slit was 27 micrometers at the opening and nearly 0 micrometers at the output. Haga and Wind interpreted a diffuse broadening of the X-rays emitted at the narrower end of the slit as a diffraction pattern. Haga was one of the founders of the "Nederlandse Natuurkundige Vereniging" (Dutch Physics Association). In addition to Cornelis Harm Wind (1867–1911), Haga's doctoral students include the crystallographer Pieter Terpstra (1886–1973) and Ekko Oosterhuis (1886–1966), who was the second scientist to join the "Philips Natuurkundig Laboratorium". In 1896 Haga became a member of the Royal Netherlands Academy of Arts and Sciences. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38216204 | Hermanus Haga | [
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Bridged nucleic acid A bridged nucleic acid (BNA) is a modified RNA nucleotide. They are sometimes also referred to as constrained or inaccessible RNA molecules. BNA monomers can contain a five-membered, six-membered or even a seven-membered bridged structure with a “fixed” C’-endo sugar puckering. The bridge is synthetically incorporated at the 2’, 4’-position of the ribose to afford a 2’, 4’-BNA monomer. The monomers can be incorporated into oligonucleotide polymeric structures using standard phosphoamidite chemistry. BNAs are structurally rigid oligo-nucleotides with increased binding affinities and stability. Chemical structures of BNA monomers containing a bridge at the 2’, 4’-position of the ribose to afford a 2’, 4’-BNA monomer as synthesized by Takeshi Imanishi's group. The nature of the bridge can vary for different types of monomers. The 3D structures for A-RNA and B-DNA were used as a template for the design of the BNA monomers. The goal for the design was to find derivatives that possess high binding affinities with complementary RNA and/or DNA strands. An increased conformational inflexibility of the sugar moiety in nucleosides (oligonucleotides) results in a gain of high binding affinity with complementary single-stranded RNA and/or double-stranded DNA. The first 2’,4’-BNA (LNA) monomers were first synthesized by Takeshi Imanishi's group in 1997 followed independently by Jesper Wengel's group in 1998. BNA nucleotides can be incorporated into DNA or RNA oligonucleotides at any desired position | Natural_sciences | https://en.wikipedia.org/wiki?curid=38260038 | Bridged nucleic acid | [
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Bridged nucleic acid Such oligomers are synthesized chemically and are now commercially available. The bridged ribose conformation enhances base stacking and pre-organizes the backbone of the oligonucleotide significantly increasing their hybridization properties. The incorporation of BNAs into oligonucleotides allows the production of modified synthetic oligonucleotides with equal or higher binding affinity against an DNA or RNA complement with excellent single-mismatch discriminating power; better RNA selective binding; stronger and more sequence selective triplex-forming characters; pronounced higher nuclease resistance, even higher than Sp-phosphorothioate analogues; and good aqueous solubility of the resulting oligonucleotides when compared to regular DNA or RNA oligonucleotides. New BNA analogs introduced by Imanishi's group were designed by taking the length of the bridged moiety into account. A six-membered bridged structure with a unique structural feature (N-O bond) in the sugar moiety was designed to have a nitrogen atom. This atom improves the formation of duplexes and triplexes by lowering the repulsion between the negatively charged backbone phosphates. These modifications allow to control the affinity towards complementary strands, regulate resistance against nuclease degradation and the synthesis of functional molecules designed for specific applications in genomics. The properties of these analogs were investigated and compared to those of previous 2’,4’-BNA (LNA) modified oligonucleotides by Imanishi's group | Natural_sciences | https://en.wikipedia.org/wiki?curid=38260038 | Bridged nucleic acid | [
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Bridged nucleic acid Imanishi's results show that “2’,4’-BNA-modified oligonucleotides with these profiles show great promise for applications in antisense and antigene technologies.” Yamamoto et al. in 2012 demonstrated that BNA-based antisense therapeutics inhibited hepatic PCSK9 expression, resulting in a strong reduction of the serum LDL-C levels of mice. The findings supported the hypothesis that PCSK9 is a potential therapeutic target for hypercholesterolemia and the researchers were able to show that BNA-based antisense oligonucleotides (AONs) induced cholesterol-lowering action in hypercholesterolemic mice. A moderate increase of aspartate aminotransferase, ALT, and blood urea nitrogen levels was observed whereas the histopathological analysis revealed no severe hepatic toxicities. The same group, also in 2012, reported that the 2’,4’-BNA[NMe] analog when used in antisense oligonucleotides showed significantly stronger inhibitory activities which is more pronounced in shorter (13- to 16mer) oligonucleotides. Their data led the researchers to conclude that the 2’,4’-BNA[NMe] analog may be a better alternative to conventional LNAs | Natural_sciences | https://en.wikipedia.org/wiki?curid=38260038 | Bridged nucleic acid | [
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Bridged nucleic acid Some of the benefits of BNAs include ideal for the detection of short RNA and DNA targets; increase the thermal stability of duplexes; capable of single nucleotide discrimination; increases the thermal stability of triplexes; resistance to exo- and endonucleases resulting in a high stability for "in vivo" and "in vitro" applications; increased target specificity; facilitate Tm normalization; strand invasion enables detection of “hard to access” samples; compatible with standard enzymatic processes. Application of BNAs include small RNA research; design and synthesis of RNA aptamers; siRNA; antisense probes; diagnostics; isolation; microarray analysis; Northern blotting; real-time PCR; "in situ" hybridization; functional analysis; SNP detection and use as antigens and many others nucleotide base applications. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38260038 | Bridged nucleic acid | [
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Sturtian glaciation The was a glaciation, or perhaps multiple glaciations, during the Cryogenian Period when the Earth experienced repeated large-scale glaciations. The duration of the has been variously defined,with dates ranging from 717 to 643 Ma. Stern "et al." place the period at 715 to 680 Ma. According to Eyles and Young, "Glaciogenic rocks figure prominently in the Neoproterozoic stratigraphy of southeastern Australia and the northern Canadian Cordillera. The Sturtian glaciogenic succession (c. 740 Ma) unconformably overlies rocks of the Burra Group." The Sturtian succession includes two major diamictite-mudstone sequences which represent glacial advance and retreat cycles. It is stratigraphically correlated with the Rapitan Group of North America. The Sturtian is named after the Sturt River Gorge, near Bellevue Heights, South Australia. Reusch's Moraine in northern Norway may have been deposited during this period. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38265686 | Sturtian glaciation | [
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William Weymouth William Anderson Weymouth (Launceston, Tasmania, 24 March 1841 – Hobart, Tasmania, 24 May 1928) was a distinguished amateur botanist. He worked as an insurance assessor with the National Mutual Insurance Company. In 1887 he began collecting mosses and lichens, sending them to several European bryologists including Antonio Jatta in Italy, and Viktor Brotherus in Finland. Jatta named a species of lichen in honour of Weymouth called "Ochrolechia weymouthii", and Brotherus named the moss genus "Weymouthia". Weymouth published several papers on mosses from Tasmania. He published a number of papers on Tasmanian bryophytes in 1893 and 1894–1895, including: | Natural_sciences | https://en.wikipedia.org/wiki?curid=38283418 | William Weymouth | [
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McLaughlin (Martian crater) McLaughlin Crater is an old crater in the Oxia Palus quadrangle of Mars, located at . It is in diameter and deep. The crater was named after Dean B. McLaughlin, an American astronomer (1901-1965). The Mars Reconnaissance Orbiter has found evidence that the water came from beneath the surface between 3.7 billion and 4 billion years ago and remained long enough to make carbonate-related clay minerals found in layers. McLaughlin Crater, one of the deepest craters on Mars, contains Mg-Fe clays and carbonates that probably formed in a groundwater-fed alkaline lake. This type of lake could have had a massive biosphere of microscopic organisms. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38283960 | McLaughlin (Martian crater) | [
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] |
UGC 4904 is a barred spiral galaxy in the constellation Lynx, located about 77 million light-years from Earth. On October 20, 2004, a supernova impostor was observed by Japanese amateur astronomer Koichi Itagaki within the galaxy. This same star may have transitioned from a LBV star to a Wolf–Rayet star shortly before it was observed as blowing up as hypernova SN 2006jc on October 11, 2006. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38309955 | UGC 4904 | [
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Plants for Human Health Institute The (PHHI) is a North Carolina State University research and education organization located at the North Carolina Research Campus in Kannapolis, North Carolina, United States. The institute researches food crops, like fruits and vegetables, and the potential health-promoting properties they may convey when consumed. PHHI is part of the North Carolina State University College of Agriculture and Life Sciences, which staffs the institute with faculty from the departments of horticultural science; food, bioprocessing and nutrition sciences; plant and microbial biology; genetics; and agricultural and resource economics. The institute has both research and Cooperative Extension components. Mary Ann Lila, a blueberry researcher, is director of the Plants for Human Health Institute. N.C. State began operations in Kannapolis in 2007 as the Fruit and Vegetable Science Institute. The university was one of the first organizations to join the biotech hub. The program's name was changed to when the N.C. Research Campus was dedicated on October 20, 2008, in order "to more accurately reflect the groundbreaking research approach the institute will take. Institute research will focus on identifying and making available to consumers bioactive compounds in plants that prevent and treat disease." As of January 2020, PHHI has about 100 faculty and staff in Kannapolis, not including seasonal staff. researchers study the potential health-promoting properties of fruits and vegetables. The institute employs twelve lead researchers | Natural_sciences | https://en.wikipedia.org/wiki?curid=38322873 | Plants for Human Health Institute | [
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Plants for Human Health Institute The institute's mission is to discover and deliver plant-based solutions to improve human health, PHHI researchers target naturally occurring chemical compounds in plants and fresh produce, known as phytochemicals, some of which convey health-promoting properties when ingested. Institute director, Lila, and other PHHI researchers have done research into phytochemicals, such as anthocyanins present in blueberries and other crops, indicating they provide health benefits against cancer, diabetes and other chronic human diseases when consumed. In 2013, Lila was a lead researcher in a study involving athletes ingesting blueberry and green tea-infused drinks twice daily during a two-week supplementation period and then for three days of rigorous exercise. Among the results, participants experienced a prolonged spike in their metabolism (up to 14 hours) after exercise. researchers integrate expertise in biochemistry, plant breeding, epigenetics, metabolomics, pharmacogenomics, postharvest physiology and systems biology. PHHI research faculty have: The institute operates three greenhouses. The greenhouse complex provides about 10,000 square feet of space for plant trials on crops like broccoli and strawberry, and allow the institute to rent space or collaborate on research with other campus operations and businesses. Researchers also partner with the Piedmont Research Station, a research farm located near Salisbury, N.C., to grow and test field crops. Funded by a $1 million U.S | Natural_sciences | https://en.wikipedia.org/wiki?curid=38322873 | Plants for Human Health Institute | [
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] |
Plants for Human Health Institute Department of Agriculture – Agriculture & Food Research Initiative (USDA-AFRI) the Kannapolis Scholars was a program for graduate students from multiple disciplines to participate in integrated research. Led by Jack Odle, William Neal Reynolds, Professor of Nutritional Biochemistry at N.C. State, the scholars examined issues in the broad domain of functional foods, bioactive food components and human health. 30 faculty members from eight universities in North Carolina, from multiple disciplines, including food science, nutritional science, plant science, animal science, microbiology, biochemistry and metabolomics act as mentors to the Kannapolis Scholars. The Plant Pathways Elucidation Project, or P2EP, is a $1.9 million program that engaging college students from across North Carolina in education and research. Operating from June 2013 to December 2019, the program was supported by a consortium of academic and industry organizations, including the Plants for Human Health Institute. The program teamed university scientists, industry leaders and college students to explore plant health benefits, prepare student scientists to pursue careers in STEM fields (Science, Technology, Engineering and Math), and create a research knowledge base. The N.C. State Extension houses a multidisciplinary team at the N.C. Research Campus as part of the Plants for Human Health Institute. The team is an education and outreach component of PHHI directed toward STEM Education and Translational Nutrition. Blake Brown, Hugh C | Natural_sciences | https://en.wikipedia.org/wiki?curid=38322873 | Plants for Human Health Institute | [
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Plants for Human Health Institute Kiger Professor in agricultural economics at N.C. State, started the Program for Value-Added and Alternative Agriculture in 2006 with support from the N.C. Tobacco Trust Fund Commission. The program was originally created to assist the transition of tobacco-farm families to other profitable enterprises after the Tobacco Buyout in 2005. As part of N.C. State's development of the N.C. Research Campus, the program relocated to Kannapolis in 2008 as an on-site Cooperative Extension complement to the research personnel and programs with the institute. The program operated under the N.C. MarketReady brand from October 2009 until July 2012. The program has since dropped the name and been fully integrated into the institute as the N.C. State Extension component. The N.C. Research Campus is a public-private venture including eight universities, one community college, the David H. Murdock Research Institute (DHMRI), and corporate entities that collaborate to advance the fields of human health, nutrition and agriculture. It was founded by David H. Murdock, CEO of Dole Foods. The campus is built upon the former site of the Cannon Textile Mill in Kannapolis, about 30 miles north of Charlotte. The research campus represents an effort by the state of North Carolina to revitalize the region following the decline of the textile industry | Natural_sciences | https://en.wikipedia.org/wiki?curid=38322873 | Plants for Human Health Institute | [
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Plants for Human Health Institute It was announced in November 2013 that two new facilities were breaking ground at the Kannapolis campus, including a 50,000-square-foot data center (DataChambers) and a 100,000-square-foot municipal center (the new Kannapolis City Hall). The is housed on the campus in a 105,000-square-foot facility that includes research labs, lab support areas and an Advance II 700 US-2 Magnet nuclear magnetic resonance spectroscope. The institute has received $2.1 million in gift donations and $7.8 million in federal and private competitive grants, $1.42 million from the N.C. Tobacco Trust Fund Commission, $2 million from the N.C. Department of Agriculture and Consumer Services and the U.S. Department of Agriculture, $780,000 from the University of North Carolina General Administration, and $1.05 million from commodity groups and other private sponsors. This funding is in addition to state appropriations. PHHI research programs have also received significant grant funding support from the Bill & Melinda Gates Foundation and the National Institutes of Health. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38322873 | Plants for Human Health Institute | [
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Methylene bridge In organic chemistry, a methylene bridge, methylene spacer, or methanediyl group is any part of a molecule with formula --; namely, a carbon atom bound to two hydrogen atoms and connected by single bonds to two other distinct atoms in the rest of the molecule. It is the repeating unit in the skeleton of the unbranched alkanes. A methylene bridge can also act as a bidentate ligand joining two metals in a coordination compound, such as titanium and aluminum in Tebbe's reagent. A methylene bridge is often called a methylene group or simply methylene, as in "methylene chloride" (dichloromethane ). However, the term methylene group (or "methylidene") properly applies to the group when it is connected to the rest of the molecule by a double bond, giving it chemical properties very distinct from those of a bridging group. Compounds possessing a methylene bridge located between two strong electron withdrawing groups (such as nitro, carbonyl or nitrile groups) are sometimes called active methylene compounds. Treatment of these with strong bases can form enolates or carbanions, which are often used in organic synthesis. Examples include the Knoevenagel condensation and the malonic ester synthesis. Examples of compounds which contain methylene bridges include: Methylstimulant Sweet puff -oxygen isobutane mix 199±Degréss.. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38340996 | Methylene bridge | [
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Rafaël Govaerts Rafaël Herman Anna Govaerts (born 1968) is a Belgian botanist. He is particularly noted for his work on plant taxonomy. He has worked at the Royal Botanic Gardens, Kew since the 1990s, and is the principal contributor to the World Checklist of Selected Plant Families. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38352577 | Rafaël Govaerts | [
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] |
Angular momentum problem The angular momentum problem is a problem in astrophysics identified by Leon Mestel in 1965. It was found that the angular momentum of a protoplanetary disk is misappropriated when compared to models during stellar birth. The Sun and other stars are predicted by models to be rotating considerably faster than they actually are. The Sun, for example, only accounts for about 0.3 percent of the total angular momentum of the Solar System while about 60% is attributed to Jupiter. History of Solar System formation and evolution hypotheses | Natural_sciences | https://en.wikipedia.org/wiki?curid=38367028 | Angular momentum problem | [
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Biotransducer Electrochemical biosensors contain a biorecognition element that selectively reacts with the target analyte and produces an electrical signal that is proportional to the analyte concentration. In general, there are several approaches that can be used to detect electrochemical changes during a biorecognition event and these can be classified as follows: amperometric, potentiometric, impedance, and conductometric. Amperometric transducers detect change in current as a result of electrochemical oxidation or reduction. Typically, the bioreceptor molecule is immobilized on the working electrode (commonly gold, carbon, or platinum). The potential between the working electrode and the reference electrode (usually Ag/AgCl) is fixed at a value and then current is measured with respect to time. The applied potential is the driving force for the electron transfer reaction. The current produced is a direct measure of the rate of electron transfer. The current reflects the reaction occurring between the bioreceptor molecule and analyte and is limited by the mass transport rate of the analyte to the electrode. Potentiometric sensors measure a potential or charge accumulation of an electrochemical cell. The transducer typically comprises an ion selective electrode (ISE) and a reference electrode. The ISE features a membrane that selectively interacts with the charged ion of interest, causing the accumulation of a charge potential compared to the reference electrode | Natural_sciences | https://en.wikipedia.org/wiki?curid=38380954 | Biotransducer | [
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Biotransducer The reference electrode provides a constant half-cell potential that is unaffected by analyte concentration. A high impedance voltmeter is used to measure the electromotive force or potential between the two electrodes when zero or no significant current flows between them. The potentiometric response is governed by the Nernst equation in that the potential is proportional to the logarithm of the concentration of the analyte. Electrochemical impedance spectroscopy (EIS) involves measuring resistive and capacitive changes caused by a biorecognition event. Typically, a small amplitude sinusoidal electrical stimulus is applied, causing current to flow through the biosensor. The frequency is varied over a range to obtain the impedance spectrum. The resistive and capacitive components of impedance are determined from in phase and out of phase current responses. Typically, a conventional three-electrode system is made specific to the analyte by immobilizing a biorecognition element to the surface. A voltage is applied and the current is measured. The interfacial impedance between the electrode and solution changes as a result of the analyte binding. An impedance analyzer can be used to control and apply the stimulus as well as measure the impedance changes. Conductometric sensing involves measuring the change in conductive properties of the sample solution or a medium | Natural_sciences | https://en.wikipedia.org/wiki?curid=38380954 | Biotransducer | [
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Biotransducer The reaction between the biomolecule and analyte changes the ionic species concentration, leading to a change in the solution electrical conductivity or current flow. Two metal electrodes are separated at a certain distance and an AC potential is applied across the electrodes, causing a current flow between the electrodes. During a biorecognition event the ionic composition changes, using an ohmmeter the change in conductance can be measured. Optical biotransducers, used in optical biosensors for signal transduction, use photons in order to collect information about analyte. These are highly sensitive, highly specific, small in size and cost effective. The detection mechanism of optical biotransducer depends upon the enzyme system that converts analyte into products which are either oxidized or reduced at the working electrode. Evanescent field detection principle is most commonly used in an optical biosensor system as the transduction principle . This principle is one of the most sensitive detection methods. It enables the detection of fluorophores exclusively in the close proximity of the optical fiber. Electronic biosensing offers significant advantages over optical, biochemical and biophysical methods, in terms of high sensitivity and new sensing mechanisms, high spatial resolution for localized detection, facile integration with standard wafer-scale semiconductor processing and label-free, real-time detection in a nondestructive manner [6] | Natural_sciences | https://en.wikipedia.org/wiki?curid=38380954 | Biotransducer | [
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Biotransducer Devices based on field-effect transistors (FETs) have attracted great attention because they can directly translate the interactions between target biological molecules and the FET surface into readable electrical signals. In a FET, current flows along the channel which is connected to the source and the drain. The channel conductance between the source and the drain is switched on and off by gate electrode that is capacitively coupled through a thin dielectric layer [6]. In FET-based biosensors, the channel is in direct contact with the environment, and this gives better control over the surface charge. This improves the sensitivity of surface FET-based biosensors as biological events occurring at the channel surface could result in the surface potential variation of the semiconductor channel and then modulate the channel conductance. In addition to ease of on-chip integration of device arrays and the cost-effective device fabrication, the surface ultrasensitivity of FET-based biosensors makes it an attractive alternative to existing biosensor technologies[6]. Gravimetric biosensors use the basic principle of a response to a change in mass. Most gravimetric biosensors use thin piezoelectric quartz crystals, either as resonating crystals (QCM), or as bulk/surface acoustic wave (SAW) devices. In the majority of these the mass response is inversely proportional to the crystal thickness. Thin polymer films are also used in which biomolecules can be added to the surface with known surface mass | Natural_sciences | https://en.wikipedia.org/wiki?curid=38380954 | Biotransducer | [
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Biotransducer Acoustic waves can be projected to the thin film to produce an oscillatory device, which then follows an equation that is nearly identical to the Sauerbrey equation used in the QCM method. Biomolecules, such as proteins or antibodies can bind and its change in mass gives a measureable signal proportional to the presence of the target analyte in the sample. Pyroelectric biosensors generate an electric current as a result of a temperature change. This differential induces a polarization in the substance, producing a dipole moment in the direction of the temperature gradient. The result is a net voltage across the material. This net voltage can be calculated by the following equation. formula_1 formula_2 where V = Voltage, ω = angular frequency of the modulated incident, P = pyroelectric coefficient, L = film thickness, ε = film dielectric constant, A = area of film, r = resistance of the film, C = capacitance of the film, τE = electrical time constant of the detector output. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38380954 | Biotransducer | [
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Turnip crinkle virus (TCV) hairpin H4 In molecular biology, is an RNA hairpin found at the 3' end of the Turnip crinkle virus (TCV) genome. The 3' end of the TCV genome contains the hairpin H4, a T-shaped structure (TSS), which contains hairpins 4a, 4b and hairpin 5 and a promoter hairpin. H4 enhances transcription and translation of the viral genome. | Natural_sciences | https://en.wikipedia.org/wiki?curid=38392431 | Turnip crinkle virus (TCV) hairpin H4 | [
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Animal Coloration (book) Animal Coloration, or in full Animal Coloration: An Account of the Principal Facts and Theories Relating to the Colours and Markings of Animals, is a book by the English zoologist Frank Evers Beddard, published by Swan Sonnenschein in 1892. It formed part of the ongoing debate amongst zoologists about the relevance of Charles Darwin's theory of natural selection to the observed appearance, structure, and behaviour of animals, and vice versa. Beddard states in the book that it contains little that is new, intending instead to give a clear overview of the subject. The main topics covered are camouflage, then called 'protective coloration'; mimicry; and sexual selection. Arguments for and against these aspects of animal coloration are intensively discussed in the book. The book was reviewed in 1892 by the major journals including "The Auk", "Nature", and "Science". The scientist reviewers Joel Asaph Allen, Edward Bagnall Poulton and Robert Wilson Shufeldt took up different positions on the book and accordingly praised or criticized Beddard's work. Modern evaluation of the book is from a variety of perspectives, including the history of Darwinism, the history of the Thayer debate on the purpose of camouflage, the mechanisms of camouflage, sexual selection, and mimicry. Beddard is seen as having covered a wide swath of modern biology with both theory and experiment. Beddard (1858–1925) was an English zoologist specializing in Annelid worms, but writing much more widely on topics including mammals and zoogeography | Natural_sciences | https://en.wikipedia.org/wiki?curid=38398925 | Animal Coloration (book) | [
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Animal Coloration (book) He also contributed articles on earthworms, leeches and nematode worms to the 1911 "Encyclopædia Britannica". His decision to write an accessible book on animal coloration falls into this pattern. Beddard wrote "Animal Coloration" at a time when scientists' confidence in Charles Darwin's theory of evolution by natural selection was at a low ebb. Beddard's book was part of an ongoing debate among zoologists about how far natural selection affected animals, and how far other forces – such as the direct action of light – might be the causes of observed features such as the colours of animals. Edward Bagnall Poulton's far more strongly pro-Darwinian book "The Colours of Animals" had appeared just two years earlier in 1890. Beddard explains in his preface that the book grew from his 1890 Davis Lectures given for the public at London Zoo. The book "contains hardly anything novel, but professes to give some account of the principal phenomena of coloration exhibited by animals." He also notes that since Poulton's recent book "deal[s] with colour almost entirely from the point of view of natural selection, I have attempted to lay some stress upon other aspects of the question." Similarly, because Poulton treated insects in some detail, Beddard chooses to give more attention to other groups, though "it is impossible not to devote a good deal of space to insects" | Natural_sciences | https://en.wikipedia.org/wiki?curid=38398925 | Animal Coloration (book) | [
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