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ESGBERT 33

We work with local and global partners to raise awareness and offer training, screening and reducedcost treatment, as applicable.

> Ethics and transparency: we seek to create positive societal impact and embed ethical behaviour in all our business activities, markets and value chain.

The Supervisory Board notes that, in its opinion, gender is only one element of diversity, and that experience, background, knowledge, skills and insight are equally important and relevant criteria in selecting new members as is also reflected in its profile.

To address this risk, we have launched an internal well-being programme.

Nevertheless, it is not possible to rule out a lack of availability of IT infrastructure or a breach in data security.

For example, UNLEASH is a new talent management programme launched in Africa, Middle East & Eastern Europe (AMEE) region.

The Executive Director Global Audit has direct access to the Audit Committee, primarily through its Chairperson.

The Group’s Human Resources dashboard allows data at all locations, including key metrics such as employee age, gender, ethnicity, and length of service.

We drive accessibility of medicines for diverse, equitable and inclusive patient groups through company policy and programming, including core pricing principles and access programmes.

So far, we have identified fair wage gaps for our direct employees in seven operating companies and already closed these gaps in the majority of them.

There are annual performance evaluations to ensure employee development is aligned with business goals and we empower managers to recognise individual successes throughout the year.

Our sustainability approach Our ambition is to harness the power of science and innovation in ways that have a positive impact on society, patients, healthcare systems and the environment, through actions for the long term.

We actively encourage everyone to Speak Up when they have questions or concerns about potential misconduct such as fraud, discrimination, harassment or corruption, also anonymously.

The people and governance committee reviews workforce policies and practices and their alignment with Company’s strategy, purpose, values and culture and conducts workforce engagement measures.

Various regulators, U.S. states and territories are considering similar requirements or have adopted laws, rules and regulations pertaining to privacy and/or information and cyber security that may be more stringent and/or expansive than federal requirements.

We would like to extend our deepest condolences to his family and friends.

Communication of policy commitments: workers and external stakeholders Our Code of Business Conduct, Human Rights Policy and Supplier Code are available in all relevant languages (around information is accessible to intended audiences.

Aim and wellbeing of our employees, contractors and local communities.

These laws and regulations include, but are not limited to: trade, transportation and logistic laws, including tariffs and import and export regulations; tax laws and regulations; product and consumer safety laws; anti-bribery and corruption laws; employment and labor laws; antitrust or competition laws; data privacy laws; and environmental regulations.

As would be expected from an international business, ethnic diversity varies between the Group’s office locations.

Such data could be wrongfully accessed or used by employees, customers, suppliers or third parties, or lost, disclosed or improperly processed in breach of data protection regulations.

Our unique culture places significant emphasis on empowering employees, together with an overarching focus on wellbeing.

Awareness and focus on human rights risks has increased significantly throughout the last three years.

In addition, the Remuneration Committee discussed and prepared a revision of the Remuneration Policy for the Executive Board to include ESG-related performance measures in the Long-term incentive plan (LTIP).

This analysis includes actual employee population and salary details in an operating company.

The evaluation identified the need for continued education and briefing sessions to develop further Board members’ knowledge and understanding of rare diseases and Alexion, Company Rare Disease, acknowledging that the appointment of two new Board members from Alexion during underpin the Board’s level of expertise in this area.

– Sustainable volume: measured in accordance with the Sustainable Agriculture Initiative (SAI): The efficient production of safe, high quality agricultural products, in a way that protects and improves the natural environment, social and economic conditions of farmers, their employees and local communities, and safeguards the health and welfare of all farmed species.

However, when changes in base salary are considered, broader factors are taken into account, including but not limited to the individual and business performance and the internal pay relativities.

We take every opportunity to raise awareness and keep our employees engaged through continuous communications on our responsible business conduct principles.

Third-party vendors fail to comply with our Vendor Code of Conduct or any third parties with which we have a business relationship with fail to represent our brands in a manner consistent with our brand image.

The Company is committed to providing a safe working environment for our people, as well as supporting our people in achieving and maintaining their health and well-being goals.

Having said that, we are cognisant of the Parker Review recommendations regarding ethnic diversity and will also take these considerations into account in our future appointments The Board is pleased to confirm that it has achieved the Hampton-Alexander Review target of on the Board.

Any errors, failures or delays in complying with AML and counter-terrorist financing laws, perceived deficiencies in our AML programs or association of our business with money laundering, terrorist financing, tax fraud or other illicit activity can give rise to significant supervisory, criminal and civil proceedings and lawsuits, which could result in significant penalties and forfeiture of assets, loss of licenses or restrictions on business activities, or other enforcement actions.

If this net revenue reduction was solely due to reductions in oil prices in isolation, it reflects an indicative decrease in the carrying amount of using price assumptions for Brent oil broadly in the middle of the range of prices associated with a pre-publication version (see page the World Business Council for Sustainable Development (WBCSD) 'family' of scenarios considered to be consistent with limiting global average temperature to 1.5°C above pre-industrial levels.

Increasing our focus on parity, Company® announced several upcoming sponsorships of women's sports, including UEFA Women's Football and the Formula 1 W Series.

In the normal course of the group’s business, Company group entities are subject to legal and regulatory proceedings arising out of current and past operations, including matters related to commercial disputes, product liability, antitrust, commodities trading, premises-liability claims, consumer protection, general health, safety, climate change and environmental claims and allegations of exposures of third parties to toxic substances, such as lead pigment in paint, asbestos and other chemicals.

As the availability of quality (emergency) health care services varies across the large number of countries and regions in which we operate, ensuring access to quality medical care to our national and international employees and their family members remains a priority.

Form Furthermore, the global regulatory environment is increasingly complex and demanding with frequent new and changing requirements surrounding , information security and privacy, including the China Cybersecurity Law, the California Consumer Privacy Act, and the European Union’s General Data Protection Regulation.

Recent health trends may lead to an increased risk of consumers making claims.

By calibrating the WBCSD Scenario Catalogue underpinning our strategic planning (for example, oil price or EV demand/utilization), we were able to model the impact of each variable across the full range of scenarios and each scenario family, on associated 2030 expected earnings (adjusted EBITDA) for the business area(s) with which that variable was associated.

Reporting on sustainability We updated our sustainability materiality assessment process in our sustainability frame as well as external developments related to sustainability and environmental, social and governance (ESG) issues.

See the section 'Foundation – Respecting human rights' for more detail on our Supplier Risk management programme.

> Contribution to society – their delivery across access to healthcare, environmental protection, ethics and transparency to lead in sustainability.

Digital and cyber security risk: including user access controls, misuse of information and systems and disruption of business activity.

The board, as a whole, is supportive of the group’s employee-led business resource groups (BRGs) which centre around specific themes including, among others, ethnicity, sexual orientation, working parents and people with disabilities.

> Taking bold action on climate, recognising the interconnection between the health of people, society and our planet.

Company has established ‘Put Safety First’ as its top priority for employees and contractors at all levels.

• Our analysis supports our view that our strategy is resilient to a range of climaterelated oil price scenarios including those consistent with well-below outcomes.a Having identified that oil price associated with the most extreme cases of the family of 1.5°C scenarios was the only variable with the potential to have financial impacts of sufficient materiality to potentially impact the resilience of our strategy, we then considered the resilience of our strategy to this potential downside.

The safety strategy focuses on implementing programmes, processes and tools to address key risks including road safety, contractor safety as well as developing strong health and safety leadership and culture.

Our stance on political activity is defined in our code of conduct.

With social impact, we want to make a positive difference for communities based on what matters most for that community.

Two of the four main board committees are chaired by a female director, one of whom holds the position of senior independent director.

Listening to our employees We treat people equally and fairly and employ, reward and promote, based on the principle of equal opportunity.

In partnership with its customers and associates, the Company is proud to support community partners with a focus on youth mental health and wellness, diversity, equity and inclusion and environmental advocacy.

As a result, the assumptions used to value the liabilities for the Group’s main retirement benefit obligations are updated every quarter.

Our commitments We include targets on our global scorecard to increase representation of women in leadership positions, as well as to increase the percentage of leaders from Emerging Markets and Japan that report into our Senior Executive Team (SET).

With the appointment of Aradhana Sarin as CFO, there are five women on our Board (total).

Benefits consist primarily of retirement, insurance and healthcare plans that are designed to provide a reasonable level of support for the employees and their dependants in case of retirement, disability or death.

Female promotions target Female promotions as a percentage of total annual promotions, with a target of 50% compared to the 2021 baseline of 39%.

A new cultivation protocol has been piloted by two farms to produce barley with a lower environmental footprint without reducing farmers’ income or product quality.

The Code is regularly reviewed and updated as necessary to ensure it reflects the highest standards of behaviour and professionalism necessary to maintain confidence in the Group's integrity.

Sustainable aviation fuel (SAF) is expected to play a critical part in decarbonizing this sector and we are working at pace to promote SAF availability, accessibility and affordability.

The Articles of Association provide entitlement to the directors’ pensions and death and disability benefits to the directors’ relations and dependants respectively.

The Board considered: investors; communities; employees; governments; regulators; patients; the impact of the Company’s operations on the community and environment; the long-term success of the Company; and maintaining high standards of business conduct.

As always, our priority is the safety and wellbeing of our colleagues, and we are also taking steps to back our impacted customers and communities.

Difficulty accessing debt and equity capital on attractive terms, or at all, and a severe disruption and instability in the global financial markets or deterioration in credit and financing conditions may affect our access to capital necessary to fund business operations or address maturing liabilities.

– Assessment: Evaluation of possible pay gap per employee per operating company in scope.

We will use the findings to raise awareness among our suppliers on potential water risks and develop programmes to manage them in the coming years.

The table below illustrates life expectancy assumptions at age expected to retire in 2041 (2020: 2020 and 2040 respectively).

By the end of have a social impact initiative signed-off and have started implementation.

Variable compensation is provided through short-term and long-term incentives based on strategic, financial and ESG objectives, recognizing Group, Business Area and Corporate Function performance as well as individual performance.

Our activities are focused on healthcare in the community and supporting science education.

We use a global cybersecurity framework and a global cybersecurity community to address confidentiality, integrity and availability risks.

Our aim is to ensure that the employees at our sites leave work at the end of each day as healthy as when they arrived.

Contributing to society by improving access to healthcare, environmental protection, and ethics and transparency, as well as delivering our Ambition Zero Carbon programme.

However, there is more to be done across all these areas to better manage the Group’s governance and its impact on the environment and society (generally referred to as ESG) in order to support the Group’s long-term, sustainable growth plans.

Percentage of employees per employee category, by age group, gender and other indicators of diversity (e.g. ethnicity).

(a) Represents mortgage-backed securities guaranteed by Fannie Mae, Freddie Mac or Ginnie Mae. (b) Represents investments in Corporate debt securities and debt securities issued by Community Development Financial Institutions.

Through our Positive Sourcing Programme, we promote ethical behaviour among our suppliers.

We reinforced our commitment to ethical behaviour through our of Ethics training, which was delivered to relevant employees and third parties.

By understanding patients’ unique needs, we can research and develop innovative medicines, support access and advocate for the rare disease community.

Discrimination against Company cards could have a material adverse effect on our business, financial condition and results of operations, particularly where it only or disproportionately impacts credit card usage or card usage generally, our Card Members or our business.

The contractual terms of the hybrid bonds allow the group to defer coupon payments and the repayment of principal indefinitely, however their terms and conditions stipulate that any deferred payments must be made in the event of an announcement of an ordinary share or parity equity dividend distribution or certain share repurchases or redemptions.

One is gender equality when filling leadership roles within the company.

The Company also provided associates with access to vaccinations by hosting multiple vaccine and booster clinics for global home office and distribution center associates.

The actuarial calculations are made by external actuaries based on inputs from observable market data, such as corporate bond returns and yield curves to determine the discount rates used, mortality tables to determine life expectancy and inflation numbers to determine future salary and pension growth assumptions.

In addition, if we are unable to attract and retain talent at the associate level without adequate succession plans, our business could be adversely impacted as competition for such qualified talent is intense, and we cannot be sure we will be able to attract, retain and develop a sufficient number of qualified individuals in future periods.

– Equal pay for equal work between female and male colleagues.

Such meeting shall be held within eight weeks of the request and shall deal with the subjects as stated by those who wish to hold the meeting, failing which the shareholders may seek judicial leave to call a general meeting.

The Customer Safety and Due Diligence department are trained to consider a customer’s age across all of its customer risk profiling, ensuring enhanced protection and care for younger customers.

Our employees want to know they are part of a business that cares about their wellbeing and supports their professional development.

These were mostly digital meetings, but the gradual lifting of lockdown restrictions opened opportunities to visit Company’s new EV charging infrastructure on London’s Park Lane, colleagues in front-line roles during a visit to Aberdeen, and representatives from the local community surrounding our proposed low carbon hydrogen projects on Teesside in England.

Cyber security The severity, sophistication and scale of cyber attacks continues to evolve.

These factors also explain the slight decrease in the share of women in management positions.

Base salary Every year, peer group and base salary levels are reviewed, and the Remuneration Committee may propose adjustments to the Supervisory Board.

While the board aspires to achieve gender parity, progress against diversity targets is sensitive to the size of the board.

To do so, we must offer a brand portfolio that stands out and is impactful in today's society.

Provision is made for employees’ long service leave and annual leave entitlements not expected to be settled wholly within after the end of the annual reporting period in which the employees render the related service.

During the year, as part of our focus on diversity and talent development we launched our inaugural SheLeads development programme for women at feedback from the initial participants.

Growing our female talent pool Achieving our commitment on gender balance among senior management will require a strong pipeline of talents.