Predicted Entities,flag,username,timestamp
"[{""token"": ""\nDr. "", ""class_or_confidence"": null}, {""token"": ""Paul Hammond"", ""class_or_confidence"": ""neurologist""}, {""token"": """", ""class_or_confidence"": null}, {""token"": ""Paul Hammond"", ""class_or_confidence"": ""scientist""}, {""token"": "", a renowned neurologist at "", ""class_or_confidence"": null}, {""token"": ""Johns Hopkins University"", ""class_or_confidence"": ""university""}, {""token"": "", has recently published a paper in the prestigious journal \""Nature "", ""class_or_confidence"": null}, {""token"": ""Neuroscience"", ""class_or_confidence"": ""journal""}, {""token"": ""\"". His research focuses on a rare genetic mutation, found in less than 0.01% of the population, that appears to prevent the development of "", ""class_or_confidence"": null}, {""token"": ""Alzheimer's disease"", ""class_or_confidence"": ""disease""}, {""token"": "". Collaborating with researchers at the "", ""class_or_confidence"": null}, {""token"": ""University of California"", ""class_or_confidence"": ""university""}, {""token"": "", "", ""class_or_confidence"": null}, {""token"": ""San Francisco"", ""class_or_confidence"": ""city""}, {""token"": "", the team is now working to understand the mechanism by which this mutation confers its protective effect. Funded by the National Institutes of Health, their research could potentially open new avenues for "", ""class_or_confidence"": null}, {""token"": ""Alzheimer's"", ""class_or_confidence"": ""disease""}, {""token"": "" treatment.\n"", ""class_or_confidence"": null}]",,,2024-06-04 11:47:18.269343
"[{""token"": ""\n\""I recently purchased the "", ""class_or_confidence"": null}, {""token"": ""Sony WH-1000XM4 Wireless Noise-Canceling Headphones"", ""class_or_confidence"": ""product""}, {""token"": "" from "", ""class_or_confidence"": null}, {""token"": ""Amazon"", ""class_or_confidence"": ""brand""}, {""token"": "" and I must say, I'm thoroughly impressed. The package arrived in "", ""class_or_confidence"": null}, {""token"": ""New York"", ""class_or_confidence"": ""location""}, {""token"": "" within 2 days, thanks to Amazon Prime's expedited shipping.\n\nThe headphones themselves are remarkable. The "", ""class_or_confidence"": null}, {""token"": ""noise-canceling"", ""class_or_confidence"": ""features""}, {""token"": "" feature works like a charm in the bustling city environment, and the 30-hour battery life means I don't have to charge them every day. Connecting them to my "", ""class_or_confidence"": null}, {""token"": ""Samsung Galaxy S21"", ""class_or_confidence"": ""product""}, {""token"": "" was a breeze, and the sound quality is second to none.\n\nI also appreciated the customer service from "", ""class_or_confidence"": null}, {""token"": ""Amazon"", ""class_or_confidence"": ""brand""}, {""token"": "" when I had a question about the warranty. They responded within an hour and provided all the information I needed.\n\nHowever, the headphones did not come with a hard case, which was listed in the product description. I contacted "", ""class_or_confidence"": null}, {""token"": ""Amazon"", ""class_or_confidence"": ""brand""}, {""token"": "", and they offered a 10% discount on my next purchase as an apology.\n\nOverall, I'd give these headphones a "", ""class_or_confidence"": null}, {""token"": ""4.5/5"", ""class_or_confidence"": ""rating""}, {""token"": "" rating and highly recommend them to anyone looking for top-notch quality in both product and service."", ""class_or_confidence"": null}]",,,2024-06-04 11:47:19.259341
"[{""token"": ""\nSeveral studies have reported its pharmacological activities, including anti-inflammatory, antimicrobial, and antitumoral effects.\nThe effect of E-anethole was studied in the "", ""class_or_confidence"": null}, {""token"": ""osteosarcoma MG-63 cell line"", ""class_or_confidence"": ""cell line""}, {""token"": "", and the antiproliferative activity was evaluated by an MTT assay.\nIt showed a GI50 value of 60.25 \u03bcM with apoptosis induction through the mitochondrial-mediated pathway. Additionally, it induced cell cycle arrest at the G0/G1 phase, up-regulated the expression of "", ""class_or_confidence"": null}, {""token"": ""p53"", ""class_or_confidence"": ""protein""}, {""token"": "", "", ""class_or_confidence"": null}, {""token"": ""caspase-3"", ""class_or_confidence"": ""protein""}, {""token"": "", and "", ""class_or_confidence"": null}, {""token"": ""caspase-9"", ""class_or_confidence"": ""protein""}, {""token"": "", and down-regulated "", ""class_or_confidence"": null}, {""token"": ""Bcl-xL"", ""class_or_confidence"": ""protein""}, {""token"": "" expression.\nMoreover, the antitumoral activity of anethole was assessed against oral tumor Ca9-22 cells, and the cytotoxic effects were evaluated by MTT and LDH assays.\nIt demonstrated a LD50 value of 8 \u03bcM, and cellular proliferation was 42.7% and 5.2% at anethole concentrations of 3 \u03bcM and 30 \u03bcM, respectively.\nIt was reported that it could selectively and in a dose-dependent manner decrease cell proliferation and induce apoptosis, as well as induce autophagy, decrease ROS production, and increase glutathione activity. The cytotoxic effect was mediated through "", ""class_or_confidence"": null}, {""token"": ""NF-kB"", ""class_or_confidence"": ""protein""}, {""token"": "", "", ""class_or_confidence"": null}, {""token"": ""MAP kinases"", ""class_or_confidence"": ""protein""}, {""token"": "", "", ""class_or_confidence"": null}, {""token"": ""Wnt"", ""class_or_confidence"": ""protein""}, {""token"": "", "", ""class_or_confidence"": null}, {""token"": ""caspase-3"", ""class_or_confidence"": ""protein""}, {""token"": "" and -"", ""class_or_confidence"": null}, {""token"": ""9"", ""class_or_confidence"": ""protein""}, {""token"": "", and "", ""class_or_confidence"": null}, {""token"": ""PARP1"", ""class_or_confidence"": ""protein""}, {""token"": "" pathways. Additionally, treatment with anethole inhibited cyclin D1 oncogene expression, increased cyclin-dependent kinase inhibitor "", ""class_or_confidence"": null}, {""token"": ""p21WAF1"", ""class_or_confidence"": ""protein""}, {""token"": "", up-regulated "", ""class_or_confidence"": null}, {""token"": ""p53"", ""class_or_confidence"": ""protein""}, {""token"": "" expression, and inhibited the EMT markers.\n"", ""class_or_confidence"": null}]",,,2024-06-04 11:47:20.387343