diff --git "a/train_MK_books.csv" "b/train_MK_books.csv" new file mode 100644--- /dev/null +++ "b/train_MK_books.csv" @@ -0,0 +1,60745 @@ +text +"DR. MICHIO KAMI + +PROFESSOR OF THEORETICAL PHYSICS +CITY UNIVERSITY OI : NEW YORK + +THE SCIENTIFIC QUEST TO UNDERSTAND +ENHANCE, AND EMPOWER THE MIND + +DOUBLEPAY + +NEW YORK LONDON TORONTO + +SYDNEY AUCKLAND + +Copyright © 2014 by Michio Kaku + +All rights reserved. Published in the United States by Doubleday, a division of Random House, +LLC, New York, and in Canada by Random House of Canada Limited, Toronto, Penguin Random +House companies. + +www.doubleday.com + +doubleday and the portrayal of an anchor with a dolphin are registered trademarks of Random +House, LLC. + +Illustrations by Jeffrey L. Ward +Jacket design by Michael J. Windsor + + Jacket illustration © CLIP AREA/Custom media/Shutterstock +LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA +Kaku, Michio. + +The future of the mind : the scientific quest to understand, enhance, and empower the mind / +Dr. Michio Kaku, professor of Theoretical Physics, City University of New York. — First edition, +pages cm + +Includes bibliographical references." +"Includes bibliographical references. + +1. Neuropsychology. 2. Mind and body—Research. + +3. Brain—Mathematical models. 4. Cognitive neuroscience. + +5. Brain-computer interfaces. I. Title. +qp360.k 325 2014 +612.8—dc23 + +2013017338 + +ISBN 978-0-385-53082-8 (hardcover) ISBN 978-0-385-53083-5 (eBook) + +v3.1 + +This book is dedicated to my loving wife, Shizue, + +and my daughters, Michelle and Alyson + +CONTENTS + +Cover + +Title Page + +Copyright + +Dedication + +ACKNOWLEDGMENTS + +INTRODUCTION + + BOOK I: THE MIND AND CONSCIOUSNESS + +1 UNLOCKING THE MIND + +2 CONSCIOUSNESS—A PHYSICIST’S VIEWPOINT + +BOOK II: MIND OVER MATTER + +3 TELEPATHY: A PENNY FOR YOUR THOUGHTS + +4 TELEKINESIS: MIND CONTROLLING MATTER + +5 MEMORIES AND THOUGHTS MADE TO ORDER + +6 EINSTEIN’S BRAIN AND ENHANCING OUR INTELLIGENCE + +BOOK III: ALTERED CONSCIOUSNESS + +7 IN YOUR DREAMS + +8 CAN THE MIND BE CONTROLLED? + +9 ALTERED STATES OF CONSCIOUSNESS + +10 THE ARTIFICIAL MIND AND SILICON CONSCIOUSNESS + +11 REVERSE ENGINEERING THE BRAIN" +"10 THE ARTIFICIAL MIND AND SILICON CONSCIOUSNESS + +11 REVERSE ENGINEERING THE BRAIN + +12 THE FUTURE: MIND BEYOND MATTER + +13 THE MIND AS PURE ENERGY + +14 THE ALIEN MIND + +15 CONCLUDING REMARKS + +APPENDIX: QUANTUM CONSCIOUSNESS? + +NOTES + +SUGGESTED READING +ILLUSTRATION CREDITS +A Note About the Author + +Other Books by This Author + +ACKNOWLEDGMENTS + + It has been my great pleasure to have interviewed and interacted with +the following prominent scientists, all of them leaders in their fields. I +would like to thank them for graciously giving up their time for +interviews and discussions about the future of science. They have given +me guidance and inspiration, as well as a firm foundation in their +respective fields. + +I would like to thank these pioneers and trailblazers, especially those +who have agreed to appear on my TV specials for the BBC, Discovery, +and Science TV channels, and also on my national radio shows, Science +Fantastic and Explorations." +"Peter Doherty, Nobel laureate, St. Jude Children’s Research Hospital + +Gerald Edelman, Nobel laureate, Scripps Research Institute + +Leon Lederman, Nobel laureate, Illinois Institute of Technology + +Murray Gell-Mann, Nobel laureate, Santa Fe Institute and Cal Tech + +the late Henry Kendall, Nobel laureate, MIT + +Walter Gilbert, Nobel laureate, Harvard University + +David Gross, Nobel laureate, Kavli Institute for Theoretical Physics + +Joseph Rotblat, Nobel laureate, St. Bartholomew’s Hospital + +Yoichiro Nambu, Nobel laureate, University of Chicago + +Steven Weinberg, Nobel laureate, University of Texas at Austin + +Frank Wilczek, Nobel laureate, MIT + +Amir Aczel, author of Uranium Wars + +Buzz Aldrin, NASA astronaut, second man to walk on the moon +Geoff Andersen, U.S. Air Force Academy, author of The Telescope + +Jay Barbree, author of Moon Shot + +John Barrow, physicist, Cambridge University, author of Impossibility + +Marcia Bartusiak, author of Einstein’s Unfinished Symphony" +"Marcia Bartusiak, author of Einstein’s Unfinished Symphony + + Jim Bell, Cornell University astronomer + +Jeffrey Bennet, author of Beyond UFOs + +Bob Berman, astronomer, author The Secrets of the Night Sky + +Leslie Biesecker, National Institutes of Health + +Piers Bizony, author of How to Build Your Own Starship + +Michael Blaese, National Institutes of Health + +Alex Boese, founder of Museum of Hoaxes + +Nick Bostrom, transhumanist, Oxford University + +Lt. Col. Robert Bowman, Institute for Space and Security Studies + +Cynthia Breazeal, artificial intelligence, MIT Media Lab + +Lawrence Brody, National Institutes of Health + +Rodney Brooks, director of the MIT Artificial Intelligence Laboratory +Lester Brown, Earth Policy Institute +Michael Brown, astronomer, Cal Tech +James Canton, author of The Extreme Future + +Arthur Caplan, director of the Center for Bioethics at the University of +Pennsylvania" +"Arthur Caplan, director of the Center for Bioethics at the University of +Pennsylvania + +Fritjof Capra, author of The Science of Leonardo +Sean Carroll, cosmologist, Cal Tech +Andrew Chaikin, author of A Man on the Moon +Leroy Chiao, NASA astronaut + +Eric Chivian, International Physicians for the Prevention of Nuclear +War + +Deepak Chopra, author of Super Brain + +George Church, director of Harvard’s Center for Computational +Genetics + +Thomas Cochran, physicist, Natural Resources Defense Council + +Christopher Cokinos, astronomer, author of Fallen Sky + + Francis Collins, National Institutes of Health + +Vicki Colvin, nanotechnologist, University of Texas + +Neal Comins, author of Hazards of Space Travel + +Steve Cook, NASA spokesperson + +Christine Cosgrove, author of Normal at Any Cost + +Steve Cousins, CEO of Willow Garage Personal Robots Program + +Phillip Coyle, former assistant secretary of defense for the U.S. Defense +Department + +Daniel Crevier, AI, CEO of Coreco" +"Daniel Crevier, AI, CEO of Coreco + +Ken Croswell, astronomer, author of Magnificent Universe + +Steven Cummer, computer science, Duke University + +Mark Cutkowsky, mechanical engineering, Stanford University + +Paul Davies, physicist, author of Superforce + +Daniel Dennet, philosopher, Tufts University + +the late Michael Dertouzos, computer science, MIT + +Jared Diamond, Pulitzer Prize winner, UCLA + +Marriot DiChristina, Scientific American + +Peter Dilworth, MIT AI Lab + +John Donoghue, creator of Braingate, Brown University +Ann Druyan, widow of Carl Sagan, Cosmos Studios +Freeman Dyson, Institute for Advanced Study, Princeton University +David Eagleman, neuroscientist, Baylor College of Medicine +John Ellis, CERN physicist + +Paul Erlich, environmentalist, Stanford University +Daniel Fairbanks, author of Relics of Eden + +Timothy Ferris, University of California, author of Coming of Age in the +Milky Way Galaxy + +Maria Finitzo, stem cell expert, Peabody Award winner + + Robert Finkelstein, AI expert" +"Maria Finitzo, stem cell expert, Peabody Award winner + + Robert Finkelstein, AI expert + +Christopher Flavin, World Watch Institute + +Louis Friedman, cofounder of the Planetary Society + +Jack Gallant, neuroscientist, University of California at Berkeley + +James Garwin, NASA chief scientist + +Evelyn Gates, author of Einstein’s Telescope + +Michael Gazzaniga, neurologist, University of California at Santa +Barbara + +Jack Geiger, cofounder, Physicians for Social Responsibility + +David Gelertner, computer scientist, Yale University, University of +California + +Neal Gershenfeld, MIT Media Lab + +Daniel Gilbert, psychologist, Harvard University + +Paul Gilster, author of Centauri Dreams + +Rebecca Goldberg, Environmental Defense Fund + +Don Goldsmith, astronomer, author of Runaway Universe + +David Goodstein, assistant provost of Cal Tech + +J. Richard Gott III, Princeton University, author of Time Travel in +Einstein’s Universe + +Late Stephen Jay Gould, biologist, Harvard University" +"Late Stephen Jay Gould, biologist, Harvard University + +Ambassador Thomas Graham, spy satellites and intelligence gathering + +John Grant, author of Corrupted Science + +Eric Green, National Institutes of Health + +Ronald Green, author of Babies by Design + +Brian Greene, Columbia University, author of The Elegant Universe +Alan Guth, physicist, MIT, author of The Inflationary Universe + + William Hanson, author of The Edge of Medicine + +Leonard Hayflick, University of California at San Francisco Medical +School + +Donald Hillebrand, Argonne National Labs, future of the car +Frank N. von Hippel, physicist, Princeton University + +Allan Hobson, psychiatrist, Harvard University +Jeffrey Hoffman, NASA astronaut, MIT + +Douglas Hofstadter, Pulitzer Prize winner, Indiana University, author +of Godel, Escher, Bach + +John Horgan, Stevens Institute of Technology, author of The End of +Science + +Jamie Hyneman, host of MythBusters + +Chris Impey, astronomer, author of The Living Cosmos + +Robert Irie, AI Lab, MIT" +"Chris Impey, astronomer, author of The Living Cosmos + +Robert Irie, AI Lab, MIT + +P. J. Jacobowitz, PC magazine + +Jay Jaroslav, MIT AI Lab + +Donald Johanson, anthropologist, discoverer of Lucy +George Johnson, New York Times science journalist +Tom Jones, NASA astronaut +Steve Kates, astronomer + +Jack Kessler, stem cell expert, Peabody Award winner +Robert Kirshner, astronomer, Harvard University +Kris Koenig, astronomer + +Lawrence Krauss, Arizona State University, author of Physics of Star +Trek + +Lawrence Kuhn, filmmaker and philosopher, Closer to Truth + +Ray Kurzweil, inventor, author of The Age of Spiritual Machines + +Robert Lanza, biotechnology, Advanced Cell Technologies + +Roger Launius, author of Robots in Space + + Stan Lee, creator of Marvel Comics and Spider-Man + +Michael Lemonick, senior science editor of Time + +Arthur Lerner-Lam, geologist, volcanist + +Simon LeVay, author of When Science Goes Wrong + +John Lewis, astronomer, University of Arizona + +Alan Lightman, MIT, author of Einstein’s Dreams" +"John Lewis, astronomer, University of Arizona + +Alan Lightman, MIT, author of Einstein’s Dreams + +George Linehan, author of Space One + +Seth Lloyd, MIT, author of Programming the Universe + +Werner R. Loewenstein, former director of Cell Physics Laboratory, +Columbia University + +Joseph Lykken, physicist, Fermi National Laboratory + +Pattie Maes, MIT Media Lab + +Robert Mann, author of Forensic Detective + +Michael Paul Mason, author of Head Cases: Stories of Brain Injury and +Its Aftermath + +Patrick McCray, author of Keep Watching the Skies + +Glenn McGee, author of The Perfect Baby + +James McLurkin, MIT, AI Lab + +Paul McMillan, director of Space Watch + +Fulvia Melia, astronomer, University of Arizona + +William Meller, author of Evolution Rx + +Paul Meltzer, National Institutes of Health + +Marvin Minsky, MIT, author of The Society of Minds + +Hans Moravec, author of Robot + +Late Phillip Morrison, physicist, MIT" +"Hans Moravec, author of Robot + +Late Phillip Morrison, physicist, MIT + + Richard Muller, astrophysicist, University of California at Berkeley +David Nahamoo, IBM Human Language Technology +Christina Neal, volcanist + +Miguel Nicolelis, neuroscientist, Duke University + +Shinji Nishimoto, neurologist, University of California at Berkeley + +Michael Novacek, American Museum of Natural History + +Michael Oppenheimer, environmentalist, Princeton University + +Dean Ornish, cancer and heart disease specialist + +Peter Palese, virologist, Mount Sinai School of Medicine + +Charles Pellerin, NASA official + +Sidney Perkowitz, author of Hollywood Science + +John Pike, GlobalSecurity.org + +Jena Pincott, author of Do Gentlemen Really Prefer Blondes? + +Steven Pinker, psychologist, Harvard University +Thomas Poggio, MIT, artificial intelligence +Correy Powell, editor of Discover magazine +John Powell, founder of JP Aerospace" +"Richard Preston, author of Hot Zone and Demon in the Freezer +Raman Prinja, astronomer, University College London + +David Quammen, evolutionary biologist, author of The Reluctant Mr. +Darwin + +Katherine Ramsland, forensic scientist + +Lisa Randall, Harvard University, author of Warped Passages + +Sir Martin Rees, Royal Astronomer of Great Britain, Cambridge +University, author of Before the Beginning + +Jeremy Rifkin, Foundation for Economic Trends +David Riquier, MIT Media Lab +Jane Rissler, Union of Concerned Scientists +Steven Rosenberg, National Institutes of Health + + Oliver Sacks, neurologist, Columbia University +Paul Saffo, futurist, Institute of the Future +Late Carl Sagan, Cornell University, author of Cosmos +Nick Sagan, coauthor of You Call This the Future? + +Michael H. Salamon, NASA’s Beyond Einstein program +Adam Savage, host of MythBusters + +Peter Schwartz, futurist, founder of Global Business Network + +Michael Shermer, founder of Skeptic Society and Skeptic magazine" +"Michael Shermer, founder of Skeptic Society and Skeptic magazine + +Donna Shirley, NASA Mars program + +Seth Shostak, SETI Institute + +Neil Shubin, author of Your Inner Fish + +Paul Shurch, SETI League + +Peter Singer, author of Wired for War + +Simon Singh, author of The Big Bang + +Gary Small, author of iBrain + +Paul Spudis, author of Odyssey Moon Limited + +Stephen Squyres, astronomer, Cornell University + +Paul Steinhardt, Princeton University, author of Endless Universe + +Jack Stern, stem cell surgeon + +Gregory Stock, UCLA, author of Redesigning Humans +Richard Stone, author of NEOs and Tunguska +Brian Sullivan, Hayden Planetarium +Leonard Susskind, physicist, Stanford University +Daniel Tammet, author of Bom on a Blue Day +Geoffrey Taylor, physicist, University of Melbourne +Late Ted Taylor, designer of U.S. nuclear warheads +Max Tegmark, cosmologist, MIT +Alvin Toffler, author of The Third Wave +Patrick Tucker, World Future Society" +"Chris Turney, University of Wollongong, author of Ice, Mud and Blood +Neil de Grasse Tyson, director of Hayden Planetarium +Sesh Velamoor, Foundation for the Future + + Robert Wallace, author of Spycraft + +Kevin Warwick, human cyborgs, University of Reading, UK +Fred Watson, astronomer, author of Stargazer +Late Mark Weiser, Xerox PARC +Alan Weisman, author of The World Without Us + +Daniel Wertheimer, SETI at Home, University of California at Berkeley +Mike Wessler, MIT AI Lab + +Roger Wiens, astronomer, Los Alamos National Laboratory +Author Wiggins, author of The Joy of Physics + +Anthony Wynshaw-Boris, National Institutes of Health +Carl Zimmer, biologist, author of Evolution +Robert Zimmerman, author of Leaving Earth +Robert Zubrin, founder of Mars Society" +"I would also like to thank my agent, Stuart Krichevsky, who has been +at my side all these years and has given me helpful advice about my +books. I have always benefited from his sound judgment. In addition, I +would like to thank my editors, Edward Kastenmeier and Melissa +Danaczko, who have guided my book and provided invaluable editorial +advice. And I would like to thank Dr. Michelle Kaku, my daughter and a +neurology resident at Mount Sinai Hospital in New York, for stimulating, +thoughtful, and fruitful discussions about the future of neurology. Her +careful and thorough reading of the manuscript has greatly enhanced the +presentation and content of this book. + +INTRODUCTION" +"INTRODUCTION + +The two greatest mysteries in all of nature are the mind and the +universe. With our vast technology, we have been able to photograph +galaxies billions of light-years away, manipulate the genes that control +life, and probe the inner sanctum of the atom, but the mind and the +universe still elude and tantalize us. They are the most mysterious and +fascinating frontiers known to science. + +If you want to appreciate the majesty of the universe, just turn your +gaze to the heavens at night, ablaze with billions of stars. Ever since our +ancestors first gasped at the splendor of the starry sky, we have puzzled +over these eternal questions: Where did it all come from? What does it +all mean?" +"To witness the mystery of our mind, all we have to do is stare at +ourselves in the mirror and wonder, What lurks behind our eyes? This +raises haunting questions like: Do we have a soul? What happens to us +after we die? Who am “I” anyway? And most important, this brings us to +the ultimate question: Where do we fit into this great cosmic scheme? As +the great Victorian biologist Thomas Huxley once said, “The question of +all questions for humanity, the problem which lies behind all others and +is more interesting than any of them, is that of the determination of +man’s place in Nature and his relation to the Cosmos.”" +"There are 100 billion stars in the Milky Way galaxy, roughly the same +as the number of neurons in our brain. You may have to travel twenty- +four trillion miles, to the first star outside our solar system, to find an +object as complex as what is sitting on your shoulders. The mind and the +universe pose the greatest scientific challenge of all, but they also share +a curious relationship. On one hand they are polar opposites. One is +concerned with the vastness of outer space, where we encounter strange +denizens like black holes, exploding stars, and colliding galaxies. The +other is concerned with inner space, where we find our most intimate +and private hopes and desires. The mind is no farther than our next + +thought, yet we are often clueless when asked to articulate and explain +it." +"thought, yet we are often clueless when asked to articulate and explain +it. + +But although they may be opposites in this respect, they also have a +common history and narrative. Both were shrouded in superstition and +magic since time immemorial. Astrologers and phrenologists claimed to +find the meaning of the universe in every constellation of the zodiac and +in every bump on your head. Meanwhile, mind readers and seers have +been alternately celebrated and vilified over the years." +"The universe and the mind continue to intersect in a variety of ways, +thanks in no small part to some of the eye-opening ideas we often +encounter in science fiction. Reading these books as a child, I would +daydream about being a member of the Sian, a race of telepaths created +by A. E. van Vogt. I marveled at how a mutant called the Mule could +unleash his vast telepathic powers and nearly seize control of the +Galactic Empire in Isaac Asimov’s Foundation Trilogy. And in the movie +Forbidden Planet, I wondered how an advanced civilization millions of +years beyond ours could channel its enormous telekinetic powers to +reshape reality to its whims and wishes." +"Then when I was about ten, “The Amazing Dunninger” appeared on +TV. He would dazzle his audience with his spectacular magic tricks. His +motto was “For those who believe, no explanation is necessary; for those +who do not believe, no explanation will suffice.” One day, he declared +that he would send his thoughts to millions of people throughout the + + country. He closed his eyes and began to concentrate, stating that he was +beaming the name of a president of the United States. He asked people +to write down the name that popped into their heads on a postcard and +mail it in. The next week, he announced triumphantly that thousands of +postcards had come pouring in with the name “Roosevelt,” the very +same name he was “beaming” across the United States." +"I wasn’t impressed. Back then, the legacy of Roosevelt was strong +among those who had lived through the Depression and World War II, so +this came as no surprise. (I thought to myself that it would have been +truly amazing if he had been thinking of President Millard Fillmore.) + +Still, it stoked my imagination, and I couldn’t resist experimenting +with telepathy on my own, trying to read other people’s minds by +concentrating as hard as I could. Closing my eyes and focusing intently, I +would attempt to “listen” to other people’s thoughts and telekinetically + +move objects around my room. + +I failed." +"move objects around my room. + +I failed. + +Maybe somewhere telepaths walked the Earth, but I wasn’t one of +them. In the process, I began to realize that the wondrous exploits of +telepaths were probably impossible—at least without outside assistance. +But in the years that followed, I also slowly learned another lesson: to +fathom the greatest secrets in the universe, one did not need telepathic +or superhuman abilities. One just had to have an open, determined, and +curious mind. In particular, in order to understand whether the fantastic +devices of science fiction are possible, you have to immerse yourself in +advanced physics. To understand the precise point when the possible +becomes the impossible, you have to appreciate and understand the laws +of physics." +"These two passions have fired up my imagination all these years: to +understand the fundamental laws of physics, and to see how science will +shape the future of our lives. To illustrate this and to share my +excitement in probing the ultimate laws of physics, I have written the +books Hyperspace , Beyond Einstein, and Parallel Worlds. And to express +my fascination with the future, I have written Visions, Physics of the +Impossible, and Physics of the Future. Over the course of writing and +researching these books, I was continually reminded that the human +mind is still one of the greatest and most mysterious forces in the world. + +Indeed, we’ve been at a loss to understand what it is or how it works +for most of history. The ancient Egyptians, for all their glorious +accomplishments in the arts and sciences, believed the brain to be a +useless organ and threw it away when embalming their pharaohs." +"Aristotle was convinced that the soul resided in the heart, not the brain, +whose only function was to cool down the cardiovascular system. +Others, like Descartes, thought that the soul entered the body through +the tiny pineal gland of the brain. But in the absence of any solid +evidence, none of these theories could be proven. + +This “dark age” persisted for thousands of years, and with good +reason. The brain weighs only three pounds, yet it is the most complex +object in the solar system. Although it occupies only 2 percent of the +body’s weight, the brain has a ravenous appetite, consuming fully 20 +percent of our total energy (in newborns, the brain consumes an +astonishing 65 percent of the baby’s energy), while fully 80 percent of + +our genes are coded for the brain. There are an estimated 100 billion +neurons residing inside the skull with an exponential amount of neural +connections and pathways." +"Back in 1977, when the astronomer Carl Sagan wrote his Pulitzer +Prize-winning book, The Dragons of Eden, he broadly summarized what +was known about the brain up to that time. His book was beautifully +written and tried to represent the state of the art in neuroscience, which +at that time relied heavily on three main sources. The first was +comparing our brains with those of other species. This was tedious and +difficult because it involved dissecting the brains of thousands of +animals. The second method was equally indirect: analyzing victims of +strokes and disease, who often exhibit bizarre behavior because of their +illness. Only an autopsy performed after their death could reveal which +part of the brain was malfunctioning. Third, scientists could use +electrodes to probe the brain and slowly and painfully piece together +which part of the brain influenced which behavior." +"But the basic tools of neuroscience did not provide a systematic way of +analyzing the brain. You could not simply requisition a stroke victim +with damage in the specific area you wanted to study. Since the brain is +a living, dynamic system, autopsies often did not uncover the most +interesting features, such as how the parts of the brain interact, let alone +how they produced such diverse thoughts as love, hate, jealousy, and +curiosity. + +TWIN REVOLUTIONS + +Four hundred years ago, the telescope was invented, and almost +overnight, this new, miraculous instrument peered into the heart of the +celestial bodies. It was one of the most revolutionary (and seditious) +instruments of all time. All of a sudden, with your own two eyes, you" +"could see the myths and dogma of the past evaporate like the morning +mist. Instead of being perfect examples of divine wisdom, the moon had +jagged craters, the sun had black spots, Jupiter had moons, Venus had +phases, and Saturn had rings. More was learned about the universe in +the fifteen years after the invention of the telescope than in all human +history put together. + +Like the invention of the telescope, the introduction of MRI machines +and a variety of advanced brain scans in the mid-1990s and 2000s has +transformed neuroscience. We have learned more about the brain in the +last fifteen years than in all prior human history, and the mind, once +considered out of reach, is finally assuming center stage." +"Nobel laureate Eric R. Kandel of the Max Planck Institute in Tubingen, +Germany, writes, “The most valuable insights into the human mind to +emerge during this period did not come from the disciplines traditionally +concerned with the mind—philosophy, psychology, or psycho-analysis. +Instead they came from a merger of these disciplines with the biology of +the brain....” + +Physicists have played a pivotal role in this endeavor, providing a +flood of new tools with acronyms like MRI, EEG, PET, CAT, TCM, TES, +and DBS that have dramatically changed the study of the brain. +Suddenly with these machines we could see thoughts moving within the +living, thinking brain. As neurologist V. S. Ramachandran of the +University of California, San Diego, says, “All of these questions that +philosophers have been studying for millennia, we scientists can begin to +explore by doing brain imaging and by studying patients and asking the +right questions.”" +"Looking back, some of my initial forays into the world of physics +intersected with the very technologies that are now opening up the mind +for science. In high school, for instance, I became aware of a new form +of matter, called antimatter, and decided to conduct a science project on +the topic. As it is one of the most exotic substances on Earth, I had to +appeal to the old Atomic Energy Commission just to obtain a tiny +quantity of sodium-22, a substance that naturally emits a positive +electron (anti-electron, or positron). With my small sample in hand, I +was able to build a cloud chamber and powerful magnetic field that +allowed me to photograph the trails of vapor left by antimatter particles. +I didn’t know it at the time, but sodium-22 would soon become +instrumental in a new technology, called PET (positron emission +tomography), which has since given us startling new insights into the +thinking brain." +"Yet another technology I experimented with in high school was +magnetic resonance. I attended a lecture by Felix Bloch of Stanford + + University, who shared the 1952 Nobel Prize for Physics with Edward + +Purcell for the discovery of nuclear magnetic resonance. Dr. Bloch +explained to us high school kids that if you had a powerful magnetic +field, the atoms would align vertically in that field like compass needles. +Then if you applied a radio pulse to these atoms at a precise resonant +frequency, you could make them flip over. When they eventually flipped +back, they would emit another pulse, like an echo, which would allow +you to determine the identity of these atoms. (Later, I used the principle +of magnetic resonance to build a 2.3-million-electron-volt particle +accelerator in my mom’s garage.)" +"Just a couple of years later, as a freshman at Harvard University, it +was an honor to have Dr. Purcell teach me electrodynamics. Around that +same time, I also had a summer job and got a chance to work with Dr. +Richard Ernst, who was trying to generalize the work of Bloch and +Purcell on magnetic resonance. He succeeded spectacularly and would +eventually win the Nobel Prize for Physics in 1991 for laying the +foundation for the modern MRI (magnetic resonance imaging) machine. +The MRI machine, in turn, has given us detailed photographs of the +living brain in even finer detail than PET scans. + +EMPOWERING THE MIND" +"EMPOWERING THE MIND + +Eventually I became a professor of theoretical physics, but my +fascination with the mind remained. It is thrilling to see that, just within +the last decade, advances in physics have made possible some of the +feats of mentalism that excited me when I was a child. Using MRI scans, +scientists can now read thoughts circulating in our brains. Scientists can +also insert a chip into the brain of a patient who is totally paralyzed and +connect it to a computer, so that through thought alone that patient can +surf the web, read and write e-mails, play video games, control their +wheelchair, operate household appliances, and manipulate mechanical +arms. In fact, such patients can do anything a normal person can do via +a computer." +"Scientists are now going even further, by connecting the brain directly +to an exoskeleton that these patients can wear around their paralyzed +limbs. Quadriplegics may one day lead near-normal lives. Such +exoskeletons may also give us superpowers enabling us to handle deadly + +emergencies. One day, our astronauts may even explore the planets by +mentally controlling mechanical surrogates from the comfort of their + + living rooms." +"living rooms. + +As in the movie The Matrix, we might one day be able to download +memories and skills using computers. In animal studies, scientists have +already been able to insert memories into the brain. Perhaps it’s only a +matter of time before we, too, can insert artificial memories into our +brains to learn new subjects, vacation in new places, and master new +hobbies. And if technical skills can be downloaded into the minds of +workers and scientists, this may even affect the world economy. We +might even be able to share these memories as well. One day, scientists +might construct an “Internet of the mind,” or a brain-net, where +thoughts and emotions are sent electronically around the world. Even +dreams will be videotaped and then “brain-mailed” across the Internet." +"Technology may also give us the power to enhance our intelligence. +Progress has been made in understanding the extraordinary powers of +“savants” whose mental, artistic, and mathematical abilities are truly +astonishing. Furthermore, the genes that separate us from the apes are +now being sequenced, giving us an unparalleled glimpse into the +evolutionary origins of the brain. Genes have already been isolated in +animals that can increase their memory and mental performance." +"The excitement and promise generated by these eye-opening advances +are so enormous that they have also caught the attention of the +politicians. In fact, brain science has suddenly become the source of a +transatlantic rivalry between the greatest economic powers on the +planet. In January 2013, both President Barack Obama and the European +Union announced what could eventually become multibillion-dollar +funding for two independent projects that would reverse engineer the +brain. Deciphering the intricate neural circuitry of the brain, once +considered hopelessly beyond the scope of modern science, is now the +focus of two crash projects that, like the Human Genome Project, will +change the scientific and medical landscape. Not only will this give us +unparalleled insight into the mind, it will also generate new industries, +spur economic activity, and open up new vistas for neuroscience." +"Once the neural pathways of the brain are finally decoded, one can +envision understanding the precise origins of mental illness, perhaps +leading to a cure for this ancient affliction. This decoding also makes it + +possible to create a copy of the brain, which raises philosophical and +ethical questions. Who are we, if our consciousness can be uploaded into +a computer? We can also toy with the concept of immortality. Our +bodies may eventually decay and die, but can our consciousness live +forever? + +And beyond that, perhaps one day in the distant future the mind will + + be freed of its bodily constraints and roam among the stars, as several +scientists have speculated. Centuries from now, one can imagine placing +our entire neural blueprint on laser beams, which will then be sent into +deep space, perhaps the most convenient way for our consciousness to +explore the stars." +"A brilliant new scientific landscape that will reshape human destiny is +now truly opening up. We are now entering a new golden age of +neuroscience. + +In making these predictions, I have had the invaluable assistance of +scientists who graciously allowed me to interview them, broadcast their +ideas on national radio, and even take a TV crew into their laboratories. +These are the scientists who are laying the foundation for the future of +the mind. For their ideas to be incorporated into this book, I made only +two requirements: (1) their predictions must rigorously obey the laws of +physics; and (2) prototypes must exist to show proof-of-principle for +these far-reaching ideas. + +TOUCHED BY MENTAL ILLN ESS" +"TOUCHED BY MENTAL ILLN ESS + +I once wrote a biography of Albert Einstein, called Einstein’s Cosmos, and +had to delve into the minute details of his private life. I had known that +Einstein’s youngest son was afflicted with schizophrenia, but did not +realize the enormous emotional toll that it had taken on the great +scientist’s life. Einstein was also touched by mental illness in another +way; one of his closest colleagues was the physicist Paul Ehrenfest, who +helped Einstein create the theory of general relativity. After suffering +bouts of depression, Ehrenfest tragically killed his own son, who had +Down’s syndrome, and then committed suicide. Over the years, I have +found that many of my colleagues and friends have struggled to manage +mental illness in their families." +"Mental illness has also deeply touched my own life. Several years ago, +my mother died after a long battle with Alzheimer’s disease. It was +heartbreaking to see her gradually lose her memories of her loved ones, +to gaze into her eyes and realize that she did not know who I was. I +could see the glimmer of humanity slowly being extinguished. She had +spent a lifetime struggling to raise a family, and instead of enjoying her +golden years, she was robbed of all the memories she held dear. + +As the baby boomers age, the sad experience that I and many others +have had will be repeated across the world. My wish is that rapid +advances in neuroscience will one day alleviate the suffering felt by +those afflicted with mental illness and dementia. + + WHAT IS DRIVING THIS REVOLUTION?" +"WHAT IS DRIVING THIS REVOLUTION? + +The data pouring in from brain scans are now being decoded, and the +progress is stunning. Several times a year, headlines herald a fresh +breakthrough. It took 350 years, since the invention of the telescope, to +enter the space age, but it has taken only fifteen years since the +introduction of the MRI and advanced brain scans to actively connect +the brain to the outside world. Why so quickly , and how much is there to +come?" +"Part of this rapid progress has occurred because physicists today have +a good understanding of electromagnetism, which governs the electrical +signals racing through our neurons. The mathematical equations of +James Clerk Maxwell, which are used to calculate the physics of +antennas, radar, radio receivers, and microwave towers, form the very +cornerstone of MRI technology. It took centuries to finally solve the +secret of electromagnetism, but neuroscience can enjoy the fruits of this +grand endeavor. In Book I, I will survey the history of the brain and +explain how a galaxy of new instruments has left the physics labs and +given us glorious color pictures of the mechanics of thought. Because +consciousness plays so central a role in any discussion of the mind, I also +give a physicist’s perspective, offering a definition of consciousness that +includes the animal kingdom as well. In fact, I provide a ranking of +consciousness, showing how it is possible to assign a number to various" +"consciousness, showing how it is possible to assign a number to various +types of consciousness." +"But to fully answer the question of how this technology will advance, +we also have to look at Moore’s law, which states that computer power +doubles every two years. I often surprise people with the simple fact that +your cell phone today has more computer power than all of NASA when +it put two men on the moon in 1969. Computers are now powerful +enough to record the electrical signals emanating from the brain and +partially decode them into a familiar digital language. This makes it +possible for the brain to directly interface with computers to control any +object around it. The fast-growing field is called BMI (brain-machine +interface), and the key technology is the computer. In Book II, I’ll +explore this new technology, which has made recording memories, mind +reading, videotaping our dreams, and telekinesis possible." +"In Book III, I’ll investigate alternate forms of consciousness, from +dreams, drugs, and mental illness to robots and even aliens from outer +space. Here we’ll also learn about the potential to control and +manipulate the brain to manage diseases such as depression, Parkinson’s, +Alzheimer’s, and many more. I will also elaborate on the Brain Research +Through Advancing Innovative Neurotechnologies (or BRAIN) project + + announced by President Obama, and the Human Brain Project of the +European Union, which will potentially allocate billions of dollars to +decode the pathways of the brain, all the way down to the neural level. +These two crash programs will undoubtedly open up entirely new +research areas, giving us new ways to treat mental illness and also +revealing the deepest secrets of consciousness." +"After we have given a definition of consciousness, we can use it to +explore nonhuman consciousness as well (i.e., the consciousness of +robots). How advanced can robots become? Can they have emotions? +Will they pose a threat? And we can also explore the consciousness of +aliens, who may have goals totally different from ours. + +In the Appendix, I will discuss perhaps the strangest idea in all of +science, the concept from quantum physics that consciousness may be +the fundamental basis for reality. + +There is no shortage of proposals for this exploding field. Only time +will tell which ones are mere pipe dreams created by the overheated +imagination of science-fiction writers and which ones represent solid +avenues for future scientific research. Progress in neuroscience has been +astronomical, and in many ways the key has been modern physics, + +which uses the full power of the electromagnetic and nuclear forces to +probe the great secrets hidden within our minds." +"I should stress that I am not a neuroscientist. I am a theoretical +physicist with an enduring interest in the mind. I hope that the vantage +point of a physicist can help further enrich our knowledge and give a +fresh new understanding of the most familiar and alien object in the +universe: our mind. + +But given the dizzying pace with which radically new perspectives are +being developed, it is important that we have a firm grasp on how the +brain is put together. + +So let us first discuss the origins of modern neuroscience, which some +historians believe began when an iron spike sailed through the brain of a +certain Phineas Gage. This seminal event set off a chain reaction that +helped open the brain to serious scientific investigation. Although it was +an unfortunate event for Mr. Gage, it paved the way for modern science. + +BOOK I THE MIND AND CONSCIOUSNESS + +My fundamental premise about the brain is that its workings—" +"BOOK I THE MIND AND CONSCIOUSNESS + +My fundamental premise about the brain is that its workings— + + what we sometimes call “mind”—are a consequence of its +anatomy and physiology, and nothing more. + +—CARL SAGAN + +1 UNLOCKING THE MIND + +In 1848, Phineas Gage was working as a railroad foreman in Vermont, +when dynamite accidentally went off, propelling a three-foot, seven-inch +spike straight into his face, through the front part of his brain, and out +the top of his skull, eventually landing eighty feet away. His fellow +workers, shocked to see part of their foreman’s brain blown off, +immediately called for a doctor. To the workers’ (and even the doctor’s) +amazement, Mr. Gage did not die on-site." +"He was semiconscious for weeks, but eventually made what seemed +like a full recovery. (A rare photograph of Gage surfaced in 2009, +showing a handsome, confident man, with an injury to his head and left +eye, holding the iron rod.) But after this incident, his coworkers began to +notice a sharp change in his personality. A normally cheerful, helpful +foreman, Gage became abusive, hostile, and selfish. Ladies were warned +to stay clear of him. Dr. John Harlow, the doctor who treated him, +observed that Gage was “capricious and vacillating, devising many plans +of future operations, which are no sooner arranged than they are +abandoned in turn for others appearing more feasible. A child in his +intellectual capacity and manifestations, yet with the animal passions of +a strong man.” Dr. Harlow noted that he was “radically changed” and +that his fellow workers said that “he was no longer Gage.” After Gage’s +death in 1860, Dr. Harlow preserved both his skull and the rod that had" +"death in 1860, Dr. Harlow preserved both his skull and the rod that had +smashed into it. Detailed X-ray scans of the skull have since confirmed +that the iron rod caused massive destruction in the area of the brain +behind the forehead known as the frontal lobe, in both the left and right +cerebral hemispheres." +"This incredible accident would not only change the life of Phineas +Gage, it would alter the course of science as well. Previously, the +dominant thinking was that the brain and the soul were two separate +entities, a philosophy called dualism. But it became increasingly clear +that damage to the frontal lobe of his brain had caused abrupt changes + +in Gage’s personality. This, in turn, created a paradigm shift in scientific +thinking: perhaps specific areas of the brain could be traced to certain +behaviors. + + broca’s brain" +"broca’s brain + +In 1861, just a year after Gage’s death, this view was further cemented +through the work of Pierre Paul Broca, a physician in Paris who +documented a patient who appeared normal except that he had a severe +speech deficit. The patient could understand and comprehend speech +perfectly, but he could utter only one sound, the word “tan.” After the +patient died, Dr. Broca confirmed during the autopsy that the patient +suffered from a lesion in his left temporal lobe, a region of the brain near +his left ear. Dr. Broca would later confirm twelve similar cases of +patients with damage to this specific area of the brain. Today patients +who have damage to the temporal lobe, usually in the left hemisphere, +are said to suffer from Broca’s aphasia. (In general, patients with this +disorder can understand speech but cannot say anything, or else they +drop many words when speaking.)" +"Soon afterward, in 1874, German physician Carl Wernicke described +patients who suffered from the opposite problem. They could articulate +clearly, but they could not understand written or spoken speech. Often +these patients could speak fluently with correct grammar and syntax, but +with nonsensical words and meaningless jargon. Sadly, these patients +often didn’t know they were spouting gibberish. Wernicke confirmed +after performing autopsies that these patients had suffered damage to a +slightly different area of the left temporal lobe. + +The works of Broca and Wernicke were landmark studies in +neuroscience, establishing a clear link between behavioral problems, +such as speech and language impairment, and damage to specific regions +of the brain." +"Another breakthrough took place amid the chaos of war. Throughout +history, there were many religious taboos prohibiting the dissection of +the human body, which severely restricted progress in medicine. In +warfare, however, with tens of thousands of bleeding soldiers dying on +the battlefield, it became an urgent mission for doctors to develop any + +medical treatment that worked. During the Prusso-Danish War in 1864, +German doctor Gustav Fritsch treated many soldiers with gaping wounds +to the brain and happened to notice that when he touched one +hemisphere of the brain, the opposite side of the body often twitched. +Later Fritsch systematically showed that, when he electrically stimulated +the brain, the left hemisphere controlled the right side of the body, and +vice versa. This was a stunning discovery, demonstrating that the brain +was basically electrical in nature and that a particular region of the +brain controlled a part on the other side of the body. (Curiously, the use" +"of electrical probes on the brain was first recorded a couple of thousand +years earlier by the Romans. In the year A.D. 43, records show that the +court doctor to the emperor Claudius used electrically charged torpedo +fish, which were applied to the head of a patient suffering from severe +headaches.) + +The realization that there were electrical pathways connecting the +brain to the body wasn’t systematically analyzed until the 1930s, when +Dr. Wilder Penfield began working with epilepsy patients, who often +suffered from debilitating convulsions and seizures that were potentially +life-threatening. For them, the last option was to have brain surgery, +which involved removing parts of the skull and exposing the brain. +(Since the brain has no pain sensors, a person can be conscious during +this entire procedure, so Dr. Penfield used only a local anesthetic during +the operation.)" +"Dr. Penfield noticed that when he stimulated certain parts of the +cortex with an electrode, different parts of the body would respond. He +suddenly realized that he could draw a rough one-to-one correspondence +between specific regions of the cortex and the human body. His +drawings were so accurate that they are still used today in almost +unaltered form. They had an immediate impact on both the scientific +community and the general public. In one diagram, you could see which +region of the brain roughly controlled which function, and how +important each function was. For example, because our hands and +mouth are so vital for survival, a considerable amount of brain power is +devoted to controlling them, while the sensors in our back hardly +register at all. + +Furthermore, Penfield found that by stimulating parts of the temporal +lobe, his patients suddenly relived long-forgotten memories in a crystal-" +"clear fashion. He was shocked when a patient, in the middle of brain +surgery, suddenly blurted out, “It was like ... standing in the doorway at +[my] high school.... I heard my mother talking on the phone, telling my +aunt to come over that night.” Penfield realized that he was tapping into +memories buried deep inside the brain. When he published his results in +1951, they created another transformation in our understanding of the +brain. + +Figure 1. This is the map of the motor cortex that was created by Dr. Wilder Penfield, showing which +region of the brain + +controls which part of the body, (illustration credit 1.1) + + A MAP OF THE BRAIN + +By the 1950s and ’60s, it was possible to create a crude map of the brain, +locating different regions and even identifying the functions of a few of +them." +"In Figure 2, we see the neocortex, which is the outer layer of the +brain, divided into four lobes. It is highly developed in humans. All the +lobes of the brain are devoted to processing signals from our senses, +except for one: the frontal lobe, located behind the forehead. The +prefrontal cortex, the foremost part of the frontal lobe, is where most +rational thought is processed. The information you are reading right now +is being processed in your prefrontal cortex. Damage to this area can +impair your ability to plan or contemplate the future, as in the case of +Phineas Gage. This is the region where information from our senses is +evaluated and a future course of action is carried out. + +FRONTAL +LOBE + +PARIETAL +LOBE + +OCCIPITAL + +LOBE + +TEMPORAL + +LOBE + + Figure 2. The four lobes of the neocortex of the brain are responsible for different, though related, +functions, (illustration + +credit 1.2)" +"credit 1.2) + +The parietal lobe is located at the top of our brains. The right +hemisphere controls sensory attention and body image; the left +hemisphere controls skilled movements and some aspects of language. +Damage to this area can cause many problems, such as difficulty in +locating parts of your own body. + +The occipital lobe is located at the very back of the brain and +processes visual information from the eyes. Damage to this area can +cause blindness and visual impairment. + +The temporal lobe controls language (on the left side only), as well as +the visual recognition of faces and certain emotional feelings. Damage to +this lobe can leave us speechless or without the ability to recognize +familiar faces. + +THE EVOLVING BRAIN" +"THE EVOLVING BRAIN + +When you look at other organs of the body, such as our muscles, bones, +and lungs, there seems to be an obvious rhyme and reason to them that +we can immediately see. But the structure of the brain might seem +slapped together in a rather chaotic fashion. In fact, trying to map the +brain has often been called “cartography for fools.”" +"To make sense of the seemingly random structure of the brain, in 1967 +Dr. Paul MacLean of the National Institute of Mental Health applied +Charles Darwin’s theory of evolution to the brain. He divided the brain +into three parts. (Since then, studies have shown that there are +refinements to this model, but we will use it as a rough organizing +principle to explain the overall structure of the brain.) First, he noticed +that the back and center part of our brains, containing the brain stem, +cerebellum, and basal ganglia, are almost identical to the brains of +reptiles. Known as the “reptilian brain,” these are the oldest structures of +the brain, governing basic animal functions such as balance, breathing, +digestion, heartbeat, and blood pressure. They also control behaviors +such as fighting, hunting, mating, and territoriality, which are necessary +for survival and reproduction. The reptilian brain can be traced back +about 500 million years. (See Figure 3.)" +"But as we evolved from reptiles to mammals, the brain also became +more complex, evolving outward and creating entirely new structures. + + Here we encounter the “mammalian brain,” or the limbic system, which +is located near the center of the brain, surrounding parts of the reptilian +brain. The limbic system is prominent among animals living in social +groups, such as the apes. It also contains structures that are involved in +emotions. Since the dynamics of social groups can be quite complex, the +limbic system is essential in sorting out potential enemies, allies, and +rivals. + +HUMAN + +BRAIN + +Hypothalamus + +MAMMALIAN +L BRAIN . + +REPTILIAN + +BRAIN + +Corpus callosum + +Cingulate gyrus + +Frontal lobe + +Hippocampus + +Forn + +Cerebellum + +Brain stem + +Pituitary + + gland" +"Frontal lobe + +Hippocampus + +Forn + +Cerebellum + +Brain stem + +Pituitary + + gland + +Figure 3. The evolutionary history of the brain, with the reptilian brain, the limbic system (the +mammalian brain), and the +neocortex (the human brain). Roughly speaking, one can argue that the path of our brain’s evolution +passed from the +reptilian brain to the mammalian brain to the human brain, (illustration credit 1.3) + +The different parts of the limbic system that control behaviors crucial +for social animals are: + +• The hippocampus. This is the gateway to memory, where short-term +memories are processed into long-term memories. Its name means +“seahorse,” which describes its strange shape. Damage here will +destroy the ability to make new long-term memories. You are left a +prisoner of the present. + +• The amygdala. This is the seat of emotions, especially fear, where +emotions are first registered and generated. Its name means +“almond.”" +"• The thalamus. This is like a relay station, gathering sensory signals +from the brain stem and then sending them out to the various +cortices. Its name means “inner chamber.” + +• The hypothalamus. This regulates body temperature, our circadian +rhythm, hunger, thirst, and aspects of reproduction and pleasure. It +lies below the thalamus—hence its name. + +Finally, we have the third and most recent region of the mammalian +brain, the cerebral cortex, which is the outer layer of the brain. The +latest evolutionary structure within the cerebral cortex is the neocortex +(meaning “new bark”), which governs higher cognitive behavior. It is +most highly developed in humans: it makes up 80 percent of our brain’s +mass, yet is only as thick as a napkin. In rats the neocortex is smooth, +but it is highly convoluted in humans, which allows a large amount of +surface area to be crammed into the human skull." +"In some sense, the human brain is like a museum containing remnants +of all the previous stages in our evolution over millions of years, +exploding outward and forward in size and function. (This is also +roughly the path taken when an infant is born. The infant brain expands +outward and toward the front, perhaps mimicking the stages of our +evolution.) + +Although the neocortex seems unassuming, looks are deceiving. Under +a microscope you can appreciate the intricate architecture of the brain. +The gray matter of the brain consists of billions of tiny brain cells called +neurons. Like a gigantic telephone network, they receive messages from +other neurons via dendrites, which are like tendrils sprouting from one +end of the neuron. At the other end of the neuron, there is a long fiber +called the axon. Eventually the axon connects to as many as ten" +"thousand other neurons via their dendrites. At the juncture between the +two, there is a tiny gap called the synapse. These synapses act like gates, +regulating the flow of information within the brain. Special chemicals +called neurotransmitters can enter the synapse and alter the flow of +signals. Because neurotransmitters like dopamine, serotonin, and +noradrenaline help control the stream of information moving across the +myriad pathways of the brain, they exert a powerful effect on our +moods, emotions, thoughts, and state of mind. (See Figure 4.) + +This description of the brain roughly represented the state of +knowledge through the 1980s. In the 1990s, however, with the +introduction of new technologies from the field of physics, the +mechanics of thought began to be revealed in exquisite detail, +unleashing the current explosion of scientific discovery. One of the +workhorses of this revolution has been the MRI machine." +"Figure 4. Diagram of a neuron. Electrical signals travel along the axon of the neuron until they hit the +synapse. +Neurotransmitters can regulate the flow of electrical signals past the synapse, (illustration credit 1.4) + +THE MRI: WINDOW INTO THE BRAIN + +To understand the reason why this radical new technology has helped +decode the thinking brain, we have to turn our attention to some basic +principles of physics. + +Radio waves, a type of electromagnetic radiation, can pass right + + through tissue without doing damage. MRI machines take advantage of +this fact, allowing electromagnetic waves to freely penetrate the skull. In +the process, this technology has given us glorious photographs of +something once thought to be impossible to capture: the inner workings + +of the brain as it experiences sensations and emotions. Watching the +dance of lights flickering in a MRI machine, one can trace out the +thoughts moving within the brain. It’s like being able to see the inside of +a clock as it ticks." +"The first thing you notice about an MRI machine is the huge, +cylindrical magnetic coils, which can produce a magnetic field twenty to +sixty thousand times greater than the strength of Earth’s. The giant +magnet is one of the principal reasons why an MRI machine can weigh a +ton, fill up an entire room, and cost several million dollars. (MRI +machines are safer than X-ray machines because they don’t create +harmful ions. CT scans, which can also create 3-D pictures, flood the +body with many times the dosage from an ordinary X-ray, and hence +have to be carefully regulated. By contrast, MRI machines are safe when +used properly. One problem, however, is the carelessness of workers. +The magnetic field is powerful enough to send tools hurling through the +air at high velocity when turned on at the wrong time. People have been +injured and even killed in this way.)" +"MRI machines work as follows: Patients lie flat and are inserted into a +cylinder containing two large coils, which create the magnetic field. +When the magnetic field is turned on, the nuclei of the atoms inside your +body act very much like a compass needle: they align horizontally along +the direction of the field. Then a small pulse of radio energy is +generated, which causes some of the nuclei in our body to flip upside +down. When the nuclei later revert back to their normal position, they +emit a secondary pulse of radio energy, which is then analyzed by the +MRI machine. By analyzing these tiny “echoes,” one can then reconstruct +the location and nature of these atoms. Like a bat, which uses echoes to +determine the position of objects in its path, the echoes created by the +MRI machine allow scientists to re-create a remarkable image of the +inside of the brain. Computers then reconstruct the position of the +atoms, giving us beautiful diagrams in three dimensions." +"When MRIs were originally introduced, they were able to show the +static structure of the brain and its various regions. However, in the mid- +1990s, a new type of MRI was invented, called “functional” MRI, or +fMRI, which detected the presence of oxygen in the blood in the brain. +(For different types of MRI machines, scientists sometimes put a +lowercase letter in front of “MRI,” but we will use the abbreviation MRI + + to denote all the various types of MRI machines.) MRI scans cannot +directly detect the flow of electricity in the neurons, but since oxygen is +necessary to provide the energy for the neurons, oxygenated blood can +indirectly trace the flow of electrical energy in the neurons and show +how various regions of the brain interact with one another." +"Already these MRI scans have definitively disproven the idea that +thinking is concentrated in a single center. Instead, one can see electrical +energy circulating across different parts of the brain as it thinks. By +tracing the path taken by our thoughts, MRI scans have shed new light +into the nature of Alzheimer’s, Parkinson’s, schizophrenia, and a host of +other mental diseases. + +The great advantage of MRI machines is their exquisite ability to +locate minute parts of the brain, down to a fraction of a millimeter in +size. An MRI scan will create not just dots on a two-dimensional screen, +called pixels, but dots in three-dimensional space, called “voxels,” +yielding a bright collection of tens of thousands of colored dots in 3-D, in +the shape of a brain." +"Since different chemical elements respond to different frequencies of +radio, you can change the frequency of the radio pulse and therefore +identify different elements of the body. As noted, fMRI machines zero in +on the oxygen atom contained within blood in order to measure blood +flow, but MRI machines can also be tuned to identify other atoms. In just +the last decade, a new form of MRI was introduced called “diffusion +tensor imaging” MRI, which detects the flow of water in the brain. Since +water follows the neural pathways of the brain, DTI yields beautiful +pictures that resemble networks of vines growing in a garden. Scientists +can now instantly determine how certain parts of the brain are hooked +up with other parts." +"There are a couple of drawbacks to MRI technology, however. +Although they are unparalleled in spatial resolution, locating voxels +down to the size of a pinpoint in three dimensions, MRIs are not that +good in temporal resolution. It takes almost a full second to follow the +path of blood in the brain, which may not sound like a lot, but +remember that electrical signals travel almost instantly throughout the +brain, and hence MRI scans can miss some of the intricate details of +thought patterns. + +Another snag is the cost, which runs in the millions of dollars, so + +doctors often have to share the machines. But like most technology, +developments should bring down the cost over time." +"In the meantime, exorbitant costs haven’t stalled the hunt for +commercial applications. One idea is to use MRI scans as lie detectors, +which, according to some studies, can identify lies with 95 percent +accuracy or higher. The level of accuracy is still controversial, but the +basic idea is that when a person tells a lie, he simultaneously has to +know the truth, concoct the lie, and rapidly analyze the consistency of +this lie with previously known facts. Today some companies are claiming +that MRI technology shows that the prefrontal and parietal lobes light up +when someone tells a lie. More specifically, the “orbitofrontal cortex” +(which can serve, among other functions, as the brain’s “fact-checker” to +warn us when something is wrong) becomes active. This area is located +right behind the orbits of our eyes, and hence the name. The theory goes +that the orbitofrontal cortex understands the difference between the +truth and a lie and kicks into overdrive as a result. (Other areas of the" +"truth and a lie and kicks into overdrive as a result. (Other areas of the +brain also light up when someone tells a lie, such as the superiormedial +and inferolateral prefrontal cortices, which are involved in cognition.)" +"Already there are several commercial firms offering MRI machines as +lie detectors, and cases involving these machines are entering the court +system. But it’s important to note that these MRI scans indicate increased +brain activity only in certain areas. While DNA results can sometimes +have an accuracy of one part in 10 billion or better, MRI scans cannot, +because it takes many areas of the brain to concoct a lie, and these same +areas of the brain are responsible for processing other kinds of thoughts +as well. + +EEG SCANS + +Another useful tool to probe deep inside the brain is the EEG, the +electroencephalogram. The EEG was introduced all the way back in +1924, but only recently has it been possible to employ computers to +make sense out of all the data pouring in from each electrode. + +To use the EEG machine, the patient usually puts on a futuristic- +looking helmet with scores of electrodes on the surface. (More advanced +versions place a hairnet over the head containing a series of tiny" +"electrodes.) These electrodes detect the tiny electrical signals that are +circulating in the brain. + +(illustration credit 1.5) + + Figure 5. At the top, we see an image taken by a functional MRI machine, showing regions of high +mental activity. In the + +bottom image, we see the flowerlike pattern created by a diffusion MRI machine, which can follow the +neural pathways + +and connections of the brain, (illustration credit 1.5a)" +"An EEG scan differs from an MRI scan in several crucial ways. The +MRI scan, as we have seen, shoots radio pulses into the brain and then +analyzes the “echoes” that come back. This means you can vary the +radio pulse to select different atoms for analysis, making it quite +versatile. The EEG machine, however, is strictly passive; that is, it +analyzes the tiny electromagnetic signals the brain naturally emits. The +EEG excels at recording the broad electromagnetic signals that surge +across the entire brain, which allows scientists to measure the overall +activity of the brain as it sleeps, concentrates, relaxes, dreams, etc. +Different states of consciousness vibrate at different frequencies. For +example, deep sleep corresponds to delta waves, which vibrate at .1 to 4 +cycles per second. Active mental states, such as problem solving, +correspond to beta waves, vibrating from 12 to 30 cycles per second. +These vibrations allow various parts of the brain to share information" +"These vibrations allow various parts of the brain to share information +and communicate with one another, even if they are located on opposite +sides of the brain. And while MRI scans measuring blood flow can be +taken only several times a second, EEG scans measure electrical activity +instantly." +"The greatest advantage of the EEG scan, though, is its convenience +and cost. Even high school students have done experiments in their +living rooms with EEG sensors placed over their heads. + +However, the main drawback to the EEG, which has held up its +development for decades, is its very poor spatial resolution. The EEG +picks up electrical signals that have already been diffused after passing +through the skull, making it difficult to detect abnormal activity when it +originates deep in the brain. Looking at the output of the muddled EEG +signals, it is almost impossible to say for sure which part of the brain +created it. Furthermore, slight motions, like moving a finger, can distort +the signal, sometimes rendering it useless. + +PET SCANS + + Yet another useful tool from the world of physics is the positron +emission topography (PET) scan, which calculates the flow of energy in" +"the brain by locating the presence of glucose, the sugar molecule that +fuels cells. Like the cloud chamber I made as a high school student, PET +scans make use of the subatomic particles emitted from sodium-22 +within the glucose. To start the PET scan, a special solution containing +slightly radioactive sugar is injected into the patient. The sodium atoms +inside the sugar molecules have been replaced by radioactive sodium-22 +atoms. Every time a sodium atom decays, it emits a positive electron, or +positron, which is easily detected by sensors. By following the path of +the radioactive sodium atoms in sugar, one can then trace out the energy +flow within the living brain. + +The PET scan shares many of the same advantages of MRI scans but +does not have the fine spatial resolution of an MRI photo. However, +instead of measuring blood flow, which is only an indirect indicator of +energy consumption in the body, PET scans measure energy +consumption, so it is more closely related to neural activity." +"There is another drawback to PET scans, however. Unlike MRI and +EEG scans, PET scans are slightly radioactive, so patients cannot +continually take them. In general, a person is not allowed to have a PET +scan more than once a year because of the risk from radiation. + +MAGNETISM IN THE BRAIN + +Within the last decade, many new high-tech devices have entered the +tool kit of neuroscientists, including the transcranial electromagnetic +scanner (TES), magnetoencephalography (MEG), near-infrared +spectroscopy (NIRS), and optogenetics, among others." +"In particular, magnetism has been used to systematically shut down +specific parts of the brain without cutting it open. The basic physics +behind these new tools is that a rapidly changing electric field can create +a magnetic field, and vice versa. MEGs passively measure the magnetic +fields produced by the changing electric fields of the brain. These +magnetic fields are weak and extremely tiny, only a billionth of Earth’s +magnetic field. Like the EEG, the MEG is extremely good at time +resolution, down to a thousandth of a second. Its spatial resolution, +however, is only a cubic centimeter. + +Unlike the passive measurement of the MEG, the TES generates a large + + pulse of electricity, which in turn creates a burst of magnetic energy. +The TES is placed next to the brain, so the magnetic pulse penetrates the +skull and creates yet another electric pulse inside the brain. This +secondary electrical pulse, in turn, is sufficient to turn off or dampen the +activity of selected areas of the brain." +"Historically, scientists had to rely on strokes or tumors to silence +certain parts of the brain and hence determine what they do. But with +the TES, one can harmlessly turn off or dampen parts of the brain at will. +By shooting magnetic energy at a particular spot in the brain, one can +determine its function by simply watching how a person’s behavior has +changed. (For example, by shooting magnetic pulses into the left +temporal lobe, one can see that this adversely affects our ability to talk.)" +"One potential drawback of the TES is that these magnetic fields do not +penetrate very far into the interior of the brain (because magnetic fields +decrease much faster than the usual inverse square law for electricity). +TES is quite useful in turning off parts of the brain near the skull, but the +magnetic field cannot reach important centers located deep in the brain, +such as the limbic system. But future generations of TES devices may +overcome this technical problem by increasing the intensity and +precision of the magnetic field. + +Wire coil + +Pulsed magnetic field + +Stimulated +brain region + +Positioning + +frame + +Figure 6. We see the transcranial electromagnetic scanner and the magnetoencephalograph, which uses +magnetism rather +than radio waves to penetrate the skull and determine the nature of thoughts within the brain. +Magnetism can +temporarily silence parts of the brain, allowing scientists to safely determine how these regions perform +without relying" +"on stroke victims, (illustration credit 1.6) + +DEEP BRAIN STIMULATION + +Yet another tool that has proven vital to neurologists is deep brain +stimulation (DBS). The probes originally used by Dr. Penfield were +relatively crude. Today these electrodes can be hairlike and reach +specific areas of the brain deep within its interior. Not only has DBS +allowed scientists to locate the function of various parts of the brain, it +can also be used to treat mental disorders. DBS has already proven its + +worth with Parkinson’s disease, in which certain regions of the brain are +overactive and often create uncontrollable shaking of the hands. + +More recently, these electrodes have targeted a new area of the brain +(called Brodmann’s area number 25) that is often overactive in +depressed patients who do not respond to psychotherapy or drugs. Deep +brain stimulation has given almost miraculous relief after decades of +torment and agony for these long-suffering patients." +"Every year, new uses for deep brain stimulation are being found. In +fact, nearly all the major disorders of the brain are being reexamined in +light of this and other new brain-scanning technologies. This promises to +be an exciting new area for diagnosing and even treating illnesses. + +OPTOGENETICS—LIGHTING UP THE BRAIN + +But perhaps the newest and most exciting instrument in the neurologist’s +tool kit is optogenetics, which was once considered science fiction. Like +a magic wand, it allows you to activate certain pathways controlling +behavior by shining a light beam on the brain. + +Incredibly, a light-sensitive gene that causes a cell to fire can be +inserted, with surgical precision, directly into a neuron. Then, by turning +on a light beam, the neuron is activated. More importantly, this allows +scientists to excite these pathways, so that you can turn on and off +certain behaviors by flicking a switch." +"Although this technology is only a decade old, optogenetics has +already proven successful in controlling certain animal behaviors. By + + turning on a light switch, it is possible to make fruit flies suddenly fly +off, worms stop wiggling, and mice run around madly in circles. Monkey +trials are now beginning, and even human trials are in discussion. There +is great hope that this technology will have a direct application in +treating disorders like Parkinson’s and depression. + +THE TRANSPARENT BRAIN + +Like optogenetics, another spectacular new development is making the +brain fully transparent so that its neural pathways are exposed to the +naked eye. In 2013, scientists at Stanford University announced that + +they had successfully made the entire brain of a mouse transparent, as +well as parts of a human brain. The announcement was so stunning that +it made the front page of the New York Times, with the headline “Brain +as Clear as Jell-0 for Scientists to Explore.”" +"At the cellular level, cells seen individually are transparent, with all +their microscopic components fully exposed. However, once billions of +cells come together to form organs like the brain, the addition of lipids +(fats, oils, waxes, and chemicals not soluble in water) helps make the +organ opaque. The key to the new technique is to remove the lipids +while keeping the neurons intact. The scientists at Stanford did this by +placing the brain in hydrogel (a gel-like substance mainly made of +water), which binds to all the brain’s molecules except the lipids. By +placing the brain in a soapy solution with an electric field, the solution +can be flushed out of the brain, carrying along the lipids, leaving the +brain transparent. The addition of dyes can then make the neural +pathways visible. This will help to identify and map the many neural +pathways of the brain." +"Making tissue transparent is not new, but getting precisely the right +conditions necessary to make the entire brain transparent took a lot of +ingenuity. “I burned and melted more than a hundred brains,” confessed +Dr. Kwanghun Chung, one of the lead scientists in the study. The new +technique, called Clarity, can also be applied to other organs (and even +organs preserved years ago in chemicals like formalin). He has already +created transparent livers, lungs, and hearts. This new technique has +startling applications across all of medicine. In particular, it will +accelerate locating the neural pathways of the brain, which is the focus +of intense research and funding. + +FOUR FUNDAMENTAL FORCES" +"FOUR FUNDAMENTAL FORCES + + The success of this first generation of brain scans has been nothing less +than spectacular. Before their introduction, only about thirty or so +regions of the brain were known with any certainty. Now the MRI +machine alone can identify two to three hundred regions of the brain, +opening up entirely new frontiers for brain science. With so many new +scanning technologies being introduced from physics just within the last + +fifteen years, one might wonder: Are there more? The answer is yes, but +they will be variations and refinements of the previous ones, not +radically new technologies. This is because there are only four +fundamental forces—gravitational, electromagnetic, weak nuclear, and +strong nuclear—that rule the universe. (Physicists have tried to find +evidence for a fifth force, but so far all such attempts have failed.)" +"The electromagnetic force, which lights up our cities and represents +the energy of electricity and magnetism, is the source of almost all the +new scanning technologies (with the exception of the PET scan, which is +governed by the weak nuclear force). Because physicists have had over +150 years of experience working with the electromagnetic force, there is +no mystery in creating new electric and magnetic fields, so any new +brain-scanning technology will most likely be a novel modification of +existing technologies, rather than being something entirely new. As with +most technology, the size and cost of these machines will drop, vastly +increasing the widespread use of these sophisticated instruments. +Already physicists are doing the basic calculations necessary to make an +MRI machine fit into a cell phone. At the same time, the fundamental +challenge facing these brain scans is resolution, both spatial and +temporal. The spatial resolution of MRI scans will increase as the" +"temporal. The spatial resolution of MRI scans will increase as the +magnetic field becomes more uniform and as the electronics become +more sensitive. At present, MRI scans can see only dots or voxels within +a fraction of a millimeter. But each dot may contain hundreds of +thousands of neurons. New scanning technology should reduce this even +further. The holy grail of this approach would be to create an MRI-like +machine that could identify individual neurons and their connections." +"The temporal resolution of MRI machines is also limited because they +analyze the flow of oxygenated blood in the brain. The machine itself +has very good temporal resolution, but tracing the flow of blood slows it +down. In the future, other MRI machines will be able to locate different +substances that are more directly connected to the firing of neurons, +thereby allowing real-time analysis of mental processes. No matter how +spectacular the successes of the past fifteen years, then, they were just a +taste of the future. + +NEW MODELS OF THE BRAIN + + Historically, with each new scientific discovery, a new model of the +brain has emerged. One of the earliest models of the brain was the +“homunculus,” a little man who lived inside the brain and made all the +decisions. This picture was not very helpful, since it did not explain what +was happening in the brain of the homunculus. Perhaps there was a +homunculus hiding inside the homunculus." +"With the arrival of simple mechanical devices, another model of the +brain was proposed: that of a machine, such as a clock, with mechanical +wheels and gears. This analogy was useful for scientists and inventors +like Leonardo da Vinci, who actually designed a mechanical man." +"During the late 1800s, when steam power was carving out new +empires, another analogy emerged, that of a steam engine, with flows of +energy competing with one another. This hydraulic model, historians +have conjectured, affected Sigmund Freud’s picture of the brain, in +which there was a continual struggle between three forces: the ego +(representing the self and rational thought), the id (representing +repressed desires), and the superego (representing our conscience). In +this model, if too much pressure built up because of a conflict among +these three, there could be a regression or general breakdown of the +entire system. This model was ingenious, but as even Freud himself +admitted, it required detailed studies of the brain at the neuronal level, +which would take another century." +"Early in the last century, with the rise of the telephone, another +analogy surfaced—that of a giant switchboard. The brain was a mesh of +telephone lines connected into a vast network. Consciousness was a long +row of telephone operators sitting in front of a large panel of switches, +constantly plugging and unplugging wires. Unfortunately, this model +said nothing about how these messages were wired together to form the +brain. + +With the rise of the transistor, yet another model became fashionable: +the computer. The old-fashioned switching stations were replaced by +microchips containing hundreds of millions of transistors. Perhaps the +“mind” was just a software program running on “wetware” (i.e., brain +tissue rather than transistors). This model is an enduring one, even +today, but it has limitations. The transistor model cannot explain how +the brain performs computations that would require a computer the size +of New York City. Plus the brain has no programming, no Windows" +"operating system or Pentium chip. (Also, a PC with a Pentium chip is +extremely fast, but it has a bottleneck. All calculations must pass + + through this single processor. The brain is the opposite. The firing of +each neuron is relatively slow, but it more than makes up for this by +having 100 billion neurons processing data simultaneously. Therefore a +slow parallel processor can trump a very fast single processor.) + +The most recent analogy is that of the Internet, which lashes together +billions of computers. Consciousness, in this picture, is an “emergent” +phenomenon, miraculously arising out of the collective action of billions +of neurons. (The problem with this picture is that it says absolutely +nothing about how this miracle occurs. It brushes all the complexity of +the brain under the rug of chaos theory.)" +"No doubt each of these analogies has kernels of truth, but none of +them truly captures the complexity of the brain. However, one analogy +for the brain that I have found useful (albeit still imperfect) is that of a +large corporation. In this analogy, there is a huge bureaucracy and lines +of authority, with vast flows of information channeled between different +offices. But the important information eventually winds up at the +command center with the CEO. There the final decisions are made. + +If this analogy of the brain to a large corporation is valid, then it +should be able to explain certain peculiar features of the brain:" +"• Most information is “subconscious” —that is, the CEO is blissfully +unaware of the vast, complex information that is constantly flowing +inside the bureaucracy. In fact, only a tiny amount of information +finally reaches the desk of the CEO, who can be compared to the +prefrontal cortex. The CEO just has to know information important +enough to get his attention; otherwise, he would be paralyzed by an +avalanche of extraneous information. + +This arrangement is probably a by-product of evolution, since our +ancestors would have been overwhelmed with superfluous, +subconscious information flooding their brains when facing an +emergency. We are all mercifully unaware of the trillions of +calculations being processed in our brains. Upon encountering a +tiger in the forest, one does not have to be bothered with the status +of our stomach, toes, hair, etc. All one has to know is how to run. + +• “Emotions” are rapid decisions made independently at a lower" +"• “Emotions” are rapid decisions made independently at a lower + +level. Since rational thought takes many seconds, this means that it +is often impossible to make a reasoned response to an emergency; +hence lower-level brain regions must rapidly assess the situation and +make a decision, an emotion, without permission from the top. + +So emotions (fear, anger, horror, etc.) are instantaneous red flags + + made at a lower level, generated by evolution, to warn the +command center of possibly dangerous or serious situations. We +have little conscious control over emotions. For example, no matter +how much we practice giving a speech to a large audience, we still +feel nervous. + +Rita Carter, author of Mapping the Mind, writes, “Emotions are not +feelings at all but a set of body-rooted survival mechanisms that +have evolved to turn us away from danger and propel us forward to +things that may be of benefit.” + +• There is a constant clamoring for the attention of the CEO." +"• There is a constant clamoring for the attention of the CEO. + +There is no single homunculus, CPU, or Pentium chip making +decisions; instead, the various subcenters within the command +center are in constant competition with one another, vying for the +attention of the CEO. So there is no smooth, steady continuity of +thought, but the cacophony of different feedback loops competing +with one another. The concept of “I,” as a single, unified whole +making all decisions continuously, is an illusion created by our own +subconscious minds. + +Mentally we feel that our mind is a single entity, continuously and +smoothly processing information, totally in charge of our decisions. +But the picture emerging from brain scans is quite different from the +perception we have of our own mind. + +MIT professor Marvin Minsky, one of the founding fathers of +artificial intelligence, told me that the mind is more like a “society +of minds,” with different submodules, each trying to compete with +the others." +"When I interviewed Steven Pinker, a psychologist at Harvard +University, I asked him how consciousness emerges out of this mess. +He said that consciousness was like a storm raging in our brain. He +elaborated on this when he wrote that “the intuitive feeling we have +that there’s an executive T that sits in a control room of our brain, + +scanning the screens of the senses and pushing the buttons of our +muscles, is an illusion. Consciousness turns out to consist of a +maelstrom of events distributed across the brain. These events +compete for attention, and as one process outshouts the others, the +brain rationalizes the outcome after the fact and concocts the +impression that a single self was in charge all along.” + +• Final decisions are made by the CEO in the command center." +"• Final decisions are made by the CEO in the command center. + + Almost all the bureaucracy is devoted to accumulating and +assembling information for the CEO, who meets only with the +directors of each division. The CEO tries to mediate all the +conflicting information pouring into the command center. The buck +stops here. The CEO, located in the prefrontal cortex, has to make +the final decision. While most decisions are made by instinct in +animals, humans make higher-level decisions after sifting through +different bodies of information from our senses. + +• Information flows are hierarchical. Because of the vast amount of +information that must flow upward toward the CEO’s office, or +downward to the support staff, information must be arranged in +complex arrays of nested networks, with many branches. Think of a +pine tree, with the command center on top and a pyramid of +branches flowing downward, branching out into many subcenters." +"There are, of course, differences between a bureaucracy and the +structure of thought. The first rule of any bureaucracy is that “it +expands to fill the space allotted to it.” But wasting energy is a +luxury the brain cannot afford. The brain consumes only about +twenty watts of power (the power of a dim lightbulb), but that is +probably the maximum energy it can consume before the body +becomes dysfunctional. If it generates more heat, it will cause tissue +damage. Therefore the brain is constantly using shortcuts to +conserve energy. We will see throughout this book the clever and +ingenious devices that evolution has crafted, without our +knowledge, to cut corners. + +IS “REALITY” REALLY REAL? + +Everyone knows the expression “seeing is believing.” Yet much of what" +"IS “REALITY” REALLY REAL? + +Everyone knows the expression “seeing is believing.” Yet much of what + +we see is actually an illusion. For example, when we see a typical +landscape, it seems like a smooth, movielike panorama. In reality, there +is a gaping hole in our field of vision, corresponding to the location of +the optic nerve in the retina. We should see this large ugly black spot +wherever we look. But our brains fill in that hole by papering it over, by +averaging it out. This means that part of our vision is actually fake, +generated by our subconscious minds to deceive us. + +Also, we see only the center of our field of vision, called the fovea, +with clarity. The peripheral part is blurry, in order to save energy. But +the fovea is very small. To capture as much information as possible with +the tiny fovea, the eye darts around constantly. This rapid, jiggling +motion of our eyes is called saccades. All this is done subconsciously," +"giving us the false impression that our field of vision is clear and +focused. + +When I was a child and first saw a diagram showing the +electromagnetic spectrum in its true glory, I was shocked. I had been +totally unaware that huge parts of the EM spectrum (e.g., infrared light, +UV light, X-rays, gamma rays) were totally invisible to us. I began to +realize that what I saw with my eyes was only a tiny, crude +approximation of reality. (There is an old saying: “If appearance and +essence were the same thing, there would be no need for science.”) We +have sensors in the retina that can detect only red, green, and blue. This +means that we’ve never actually seen yellow, brown, orange, and a host +of other colors. These colors do exist, but our brain can approximate +each of them only by mixing different amounts of red, green, and blue. +(You can see this if you look at an old color-TV screen very carefully. +You see only a collection of red, green, and blue dots. Color TV is +actually an illusion.)" +"Our eyes also fool us into thinking we can see depth. The retinas of +our eyes are two-dimensional, but because we have two eyes separated +by a few inches, the left and right brain merge these two images, giving +us the false sense of a third dimension. For more distant objects, we can +judge how far an object is by observing how they move when we move +our head. This is called parallax. + +(This parallax explains the fact that children sometimes complain that +“the moon is following me.” Because the brain has difficulty +comprehending the parallax of an object as distant as the moon, it + +appears as if the moon is always a fixed distance “behind” them, but it’s +just an illusion caused by the brain taking a shortcut.) + +THE SPLIT-BRAIN PARADOX" +"THE SPLIT-BRAIN PARADOX + +One way in which this picture, based on the corporate hierarchy of a +company, deviates from the actual structure of the brain can be seen in +the curious case of split-brain patients. One unusual feature of the brain +is that it has two nearly identical halves, or hemispheres, the left and +right. Scientists have long wondered why the brain has this unnecessary +redundancy, since the brain can operate even if one entire hemisphere is +completely removed. No normal corporate hierarchy has this strange +feature. Furthermore, if each hemisphere has consciousness, does this +mean that we have two separate centers of consciousness inside one +skull?" +"Dr. Roger W. Sperry of the California Institute of Technology won the +Nobel Prize in 1981 for showing that the two hemispheres of the brain +are not exact carbon copies of each other, but actually perform different +duties. This result created a sensation in neurology (and also spawned a +cottage industry of dubious self-help books that claim to apply the left- +brain, right-brain dichotomy to your life). + +Dr. Sperry was treating epileptics, who sometimes suffer from grand +mal seizures often caused by feedback loops between the two +hemispheres that go out of control. Like a microphone screeching in our +ears because of a feedback loop, these seizures can become life- +threatening. Dr. Sperry began by severing the corpus callosum, which +connects the two hemispheres of the brain, so that they no longer +communicated and shared information between the left and right side of +the body. This usually stopped the feedback loop and the seizures." +"At first, these split-brain patients seemed perfectly normal. They were +alert and could carry on a natural conversation as if nothing had +happened. But a careful analysis of these individuals showed that +something was very different about them. + +Normally the hemispheres complement each other as thoughts move +back and forth between the two. The left brain is more analytical and +logical. It is where verbal skills are found, while the right brain is more + +holistic and artistic. But the left brain is the dominant one and makes the +final decisions. Commands pass from the left brain to the right brain via +the corpus callosum. But if that connection is cut, it means that the right +brain is now free from the dictatorship of the left brain. Perhaps the +right brain can have a will of its own, contradicting the wishes of the +dominant left brain." +"In short, there could be two wills acting within one skull, sometimes +struggling for control of the body. This creates the bizarre situation +where the left hand (controlled by the right brain) starts to behave +independently of your wishes, as if it were an alien appendage. + +There is one documented case in which a man was about to hug his +wife with one hand, only to find that the other hand had an entirely +different agenda. It delivered a right hook to her face. Another woman +reported that she would pick out a dress with one hand, only to see her +other hand grab an entirely different outfit. Meanwhile, one man had +difficulty sleeping at night thinking that his other rebellious hand might +strangle him. + +At times, split-brain people think they are living in a cartoon, where +one hand struggles to control the other. Physicians sometimes call this + + the Dr. Strangelove syndrome, because of a scene in the movie in which +one hand has to fight against the other hand." +"Dr. Sperry, after detailed studies of split-brain patients, finally +concluded that there could be two distinct minds operating in a single +brain. He wrote that each hemisphere is “indeed a conscious system in +its own right, perceiving, thinking, remembering, reasoning, willing, and +emoting, all at a characteristically human level, and ... both the left and +right hemisphere may be conscious simultaneously in different, even in +mutually conflicting, mental experiences that run along in parallel.”" +"When I interviewed Dr. Michael Gazzaniga of the University of +California, Santa Barbara, an authority on split-brain patients, I asked +him how experiments can be done to test this theory. There are a variety +of ways to communicate separately to each hemisphere without the +knowledge of the other hemisphere. One can, for example, have the +subject wear special glasses on which questions can be shown to each +eye separately, so that directing questions to each hemisphere is easy. +The hard part is trying to get an answer from each hemisphere. Since the +right brain cannot speak (the speech centers are located only in the left + +brain), it is difficult to get answers from the right brain. Dr. Gazzaniga +told me that to find out what the right brain was thinking, he created an +experiment in which the (mute) right brain could “talk” by using +Scrabble letters." +"He began by asking the patient’s left brain what he would do after +graduation. The patient replied that he wanted to become a draftsman. +But things got interesting when the (mute) right brain was asked the +same question. The right brain spelled out the words: “automobile +racer.” Unknown to the dominant left brain, the right brain secretly had +a completely different agenda for the future. The right brain literally had +a mind of its own. + +Rita Carter writes, “The possible implications of this are mind- +boggling. It suggests that we might all be carrying around in our skulls a +mute prisoner with a personality, ambition, and self-awareness quite +different from the day-to-day entity we believe ourselves to be.”" +"Perhaps there is truth to the oft-heard statement that “inside him, +there is someone yearning to be free.” This means that the two +hemispheres may even have different beliefs. For example, the +neurologist V. S. Ramanchandran describes one split-brain patient who, +when asked if he was a believer or not, said he was an atheist, but his +right brain declared he was a believer. Apparently, it is possible to have +two opposing religious beliefs residing in the same brain. Ramachandran +continues: “If that person dies, what happens? Does one hemisphere go + + to heaven and the other go to hell? I don’t know the answer to that.” + +(It is conceivable, therefore, that a person with a split-brain +personality might be both Republican and Democrat at the same time. If +you ask him whom he will vote for, he will give you the candidate of the +left brain, since the right brain cannot speak. But you can imagine the +chaos in the voting booth when he has to pull the lever with one hand.) + +WHO IS IN CHARGE?" +"WHO IS IN CHARGE? + +One person who has spent considerable time and done much research to +understand the problem of the subconscious mind is Dr. David +Eagleman, a neuroscientist at the Baylor College of Medicine. When I +interviewed him, I asked him, If most of our mental processes are + +subconscious, then why are we ignorant of this important fact? He gave +an example of a young king who inherits the throne and takes credit for +everything in the kingdom, but hasn’t the slightest clue about the +thousands of staff, soldiers, and peasants necessary to maintain the +throne." +"Our choice of politicians, marriage partners, friends, and future +occupations are all influenced by things that we are not conscious of. +(For example, it is an odd result, he says, that “people named Denise or +Dennis are disproportionately likely to become dentists, while people +named Laura or Lawrence are more likely to become lawyers, and +people with names like George or Georgina to become geologists.”) This +also means that what we consider to be “reality” is only an +approximation that the brain makes to fill in the gaps. Each of us sees +reality in a slightly different way. For example, he pointed out, “at least +15 percent of human females possess a genetic mutation that gives them +an extra (fourth) type of color photoreceptor—and this allows them to +discriminate between colors that look identical to the majority of us with +a mere three types of color photoreceptors.”" +"Clearly, the more we understand the mechanics of thought, the more +questions arise. Precisely what happens in the command center of the +mind when confronted with a rebellious shadow command center? What +do we mean by “consciousness” anyway, if it can be split in half? And +what is the relationship between consciousness and “self” and “self- +awareness”? + +If we can answer these difficult questions, then perhaps it will pave +the way for understanding nonhuman consciousness, the consciousness +of robots and aliens from outer space, for example, which may be + + entirely different from ours. + +So let us now propose a clear answer to this deceptively complex +question: What is consciousness? + +The mind of man is capable of anything ... because everything +is in it, all the past as well as all the future. + +—JOSEPH CONRAD + +Consciousness can reduce even the most fastidious thinker to +blabbering incoherence. + +—COLIN MCGINN + +2 CONSCIOUSNESS—A PHYSICIST’S VIEWPOINT" +"—COLIN MCGINN + +2 CONSCIOUSNESS—A PHYSICIST’S VIEWPOINT + +The idea of consciousness has intrigued philosophers for centuries, but +it has resisted a simple definition, even to this day. The philosopher +David Chalmers has cataloged more than twenty thousand papers +written on the subject; nowhere in science have so many devoted so +much to create so little consensus. The seventeenth-century thinker +Gottfried Leibniz once wrote, “If you could blow the brain up to the size +of a mill and walk about inside, you would not find consciousness.” + +Some philosophers doubt that a theory of consciousness is even +possible. They claim that consciousness can never be explained since an +object can never understand itself, so we don’t even have the mental +firepower to solve this perplexing question. Harvard psychologist Steven +Pinker writes, “We cannot see ultraviolet light. We cannot mentally +rotate an object in the fourth dimension. And perhaps we cannot solve +conundrums like free will and sentience.”" +"In fact, for most of the twentieth century, one of the dominant theories +of psychology, behaviorism, denied the importance of consciousness +entirely. Behaviorism is based on the idea that only the objective +behavior of animals and people is worthy of study, not the subjective, +internal states of the mind. + +Others have given up trying to define consciousness, and try simply to +describe it. Psychiatrist Giulio Tononi has said, “Everybody knows what +consciousness is: it is what abandons you every night when you fall into +dreamless sleep and returns the next morning when you wake up.” + + Although the nature of consciousness has been debated for centuries, +there has been little resolution. Given that physicists created many of the +inventions that have made the explosive advancements in brain science +possible, perhaps it will be useful to follow an example from physics in +reexamining this ancient question. + +HOW PHYSICISTS UNDERSTAND THE UNIVERSE" +"HOW PHYSICISTS UNDERSTAND THE UNIVERSE + +When a physicist tries to understand something, first he collects data and +then he proposes a “model,” a simplified version of the object he is +studying that captures its essential features. In physics, the model is +described by a series of parameters (e.g., temperature, energy, time). +Then the physicist uses the model to predict its future evolution by +simulating its motions. In fact, some of the world’s largest +supercomputers are used to simulate the evolution of models, which can +describe protons, nuclear explosions, weather patterns, the big bang, and +the center of black holes. Then you create a better model, using more +sophisticated parameters, and simulate it in time as well." +"For example, when Isaac Newton was puzzling over the motion of the +moon, he created a simple model that would eventually change the +course of human history: he envisioned throwing an apple in the air. The +faster you threw the apple, he reasoned, the farther it would travel. If +you threw it fast enough, in fact, it would encircle the Earth entirely, +and might even return to its original point. Then, Newton claimed, this +model represented the path of the moon, so the forces that guided the +motion of the apple circling the Earth were identical to the forces +guiding the moon." +"But the model, by itself, was still useless. The key breakthrough came +when Newton was able to use his new theory to simulate the future, to +calculate the future position of moving objects. This was a difficult +problem, requiring him to create an entirely new branch of mathematics, +called calculus. Using this new mathematics, Newton was then able to +predict the trajectory of not just the moon, but also Halley’s Comet and +the planets. Since then, scientists have used Newton’s laws to simulate +the future path of moving objects, from cannonballs, machines, +automobiles, and rockets to asteroids and meteors, and even stars and +galaxies. + +The success or failure of a model depends on how faithfully it +reproduces the basic parameters of the original. In this case, the basic +parameter was the location of the apple and the moon in space and time. +By allowing this parameter to evolve (i.e., letting time move forward), +Newton unlocked, for the first time in history, the action of moving" +"bodies, which is one of the most important discoveries in science. + +Models are useful, until they are replaced by even more accurate +models described by better parameters. Einstein replaced Newton’s + +picture of forces acting on apples and moons with a new model based on +a new parameter, the curvature of space and time. An apple moved not +because the Earth exerted a force on it, but because the fabric of space +and time was stretched by the Earth, so the apple was simply moving +along the surface of a curved space-time. From this, Einstein could then +simulate the future of the entire universe. Now, with computers, we can +run simulations of this model into the future and create gorgeous +pictures presenting the collisions of black holes. + +Let us now incorporate this basic strategy into a new theory of +consciousness. + +DEFINITION OF CONSCIOUSNESS" +"DEFINITION OF CONSCIOUSNESS + +I’ve taken bits and pieces from previous descriptions of consciousness in +the fields of neurology and biology in order to define consciousness as +follows: + +Consciousness is the process of creating a model of the world +using multiple feedback loops in various parameters (e.g., in +temperature, space, time, and in relation to others), in order to +accomplish a goal (e.g., find mates, food, shelter). + +I call this the “space-time theory of consciousness,” because it +emphasizes the idea that animals create a model of the world mainly in +relation to space, and to one another, while humans go beyond and +create a model of the world in relation to time, both forward and +backward." +"For example, the lowest level of consciousness is Level 0, where an +organism is stationary or has limited mobility and creates a model of its +place using feedback loops in a few parameters (e.g., temperature). For +example, the simplest level of consciousness is a thermostat. It +automatically turns on an air conditioner or heater to adjust the +temperature in a room, without any help. The key is a feedback loop +that turns on a switch if the temperature gets too hot or cold. (For +example, metals expand when heated, so a thermostat can turn on a +switch if a metal strip expands beyond a certain point.) + + Each feedback loop registers “one unit of consciousness,” so a +thermostat would have a single unit of Level 0 consciousness, that is, +Level 0:1." +"In this way, we can rank consciousness numerically, on the basis of +the number and complexity of the feedback loops used to create a model +of the world. Consciousness is then no longer a vague collection of +undefined, circular concepts, but a system of hierarchies that can be +ranked numerically. For example, a bacterium or a flower has many +more feedback loops, so they would have a higher level of Level 0 +consciousness. A flower with ten feedback loops (which measure +temperature, moisture, sunlight, gravity, etc.), would have a Level 0:10 +consciousness." +"Organisms that are mobile and have a central nervous system have +Level I consciousness, which includes a new set of parameters to +measure their changing location. One example of Level I consciousness +would be reptiles. They have so many feedback loops that they +developed a central nervous system to handle them. The reptilian brain +would have perhaps one hundred or more feedback loops (governing +their sense of smell, balance, touch, sound, sight, blood pressure, etc., +and each of these contains more feedback loops). For example, eyesight +alone involves a large number of feedback loops, since the eye can +recognize color, movement, shapes, light intensity, and shadows. +Similarly, the reptile’s other senses, such as hearing and taste, require +additional feedback loops. The totality of these numerous feedback loops +creates a mental picture of where the reptile is located in the world, and +where other animals (e.g., prey) are located as well. Level I" +"where other animals (e.g., prey) are located as well. Level I +consciousness, in turn, is governed mainly by the reptilian brain, located +in the back and center of the human head." +"Next we have Level II consciousness, where organisms create a model +of their place not only in space but also with respect to others (i.e., they +are social animals with emotions). The number of feedback loops for +Level II consciousness explodes exponentially, so it is useful to introduce +a new numerical ranking for this type of consciousness. Forming allies, +detecting enemies, serving the alpha male, etc., are all very complex +behaviors requiring a vastly expanded brain, so Level II consciousness +coincides with the formation of new structures of the brain in the form +of the limbic system. As noted earlier, the limbic system includes the + +hippocampus (for memories), amygdala (for emotions), and the +thalamus (for sensory information), all of which provide new parameters +for creating models in relation to others. The number and type of +feedback loops therefore change." +"We define the degree of Level II consciousness as the total number of +distinct feedback loops required for an animal to interact socially with +members of its grouping. Unfortunately, studies of animal consciousness +are extremely limited, so little work has been done to catalog all the +ways in which animals communicate socially with one another. But to a +crude first approximation, we can estimate Level II consciousness by +counting the number of fellow animals in its pack or tribe and then +listing the total number of ways in which the animal interacts +emotionally with each one. This would include recognizing rivals and +friends, forming bonds with others, reciprocating favors, building +coalitions, understanding your status and the social ranking of others, +respecting the status of your superiors, displaying your power over your +inferiors, plotting to rise on the social ladder, etc. (We exclude insects +from Level II, because although they have social relations with members" +"from Level II, because although they have social relations with members +of their hive or group, they have no emotions as far as we can tell.)" +"Despite the lack of empirical studies of animal behaviors, we can give +a very rough numerical rank to Level II consciousness by listing the total +number of distinct emotions and social behaviors that the animal can +exhibit. For example, if a wolf pack consists of ten wolves, and each wolf +interacts with all the others with fifteen different emotions and gestures, +then its level of consciousness, to a first approximation, is given by the +product of the two, or 150, so it would have Level 11:150 consciousness. +This number takes into account both the number of other animals it has +to interact with as well as the number of ways it can communicate with +each one. This number only approximates the total number of social +interactions that the animal can display, and will undoubtedly change as +we learn more about its behavior." +"(Of course, because evolution is never clean and precise, there are +caveats that we have to explain, such as the level of consciousness of +social animals that are solitary hunters. We will do so in the notes.) + +LEVEL III CONSCIOUSNESS: SIMULATING THE FUTURE + +With this framework for consciousness, we see that humans are not +unique, and that there is a continuum of consciousness. As Charles +Darwin once commented, “The difference between man and the higher +animals, great as it is, is certainly one of degree and not of kind.” But +what separates human consciousness from the consciousness of animals? +Humans are alone in the animal kingdom in understanding the concept +of tomorrow. Unlike animals, we constantly ask ourselves “What if?” +weeks, months, and even years into the future, so I believe that Level III +consciousness creates a model of its place in the world and then +simulates it into the future, by making rough predictions. We can +summarize this as follows:" +"Human consciousness is a specific form of consciousness that +creates a model of the world and then simulates it in time, by +evaluating the past to simulate the future. This requires +mediating and evaluating many feedback loops in order to +make a decision to achieve a goal. + +By the time we reach Level III consciousness, there are so many +feedback loops that we need a CEO to sift through them in order to +simulate the future and make a final decision. Accordingly, our brains +differ from those of other animals, especially in the expanded prefrontal +cortex, located just behind the forehead, which allows us to “see” into +the future." +"Dr. Daniel Gilbert, a Harvard psychologist, has written, “The greatest +achievement of the human brain is its ability to imagine objects and +episodes that do not exist in the realm of the real, and it is this ability +that allows us to think about the future. As one philosopher noted, the +human brain is an ‘anticipation machine,’ and ‘making the future’ is the +most important thing it does.” + +Using brain scans, we can even propose a candidate for the precise +area of the brain where simulation of the future takes place. Neurologist +Michael Gazzaniga notes that “area 10 (the internal granular layer IV), +in the lateral prefrontal cortex, is almost twice as large in humans as in +apes. Area 10 is involved with memory and planning, cognitive +flexibility, abstract thinking, initiating appropriate behavior, and +inhibiting inappropriate behavior, learning rules, and picking out" +"relevant information from what is perceived through the senses.” (For +this book, we will refer to this area, in which decision making is +concentrated, as the dorsolateral prefrontal cortex, although there is +some overlap with other areas of the brain.) + +Although animals may have a well-defined understanding of their +place in space and some have a degree of awareness of others, it is not +clear if they systematically plan for the future and have an +understanding of “tomorrow.” Most animals, even social animals with +well-developed limbic systems, react to situations (e.g., the presence of +predators or potential mates) by relying mainly on instinct, rather than +systematically planning into the future." +"For instance, mammals do not plan for the winter by preparing to +hibernate, but largely follow instinct as the temperature drops. There is +a feedback loop that regulates their hibernation. Their consciousness is +dominated by messages coming in from their senses. There is no +evidence that they systemically sift through various plans and schemes + + as they prepare to hibernate. Predators, when they use cunning and +disguise to stalk an unsuspecting prey, do anticipate future events, but +this planning is limited only to instinct and the duration of the hunt. +Primates are adept at devising short-term plans (e.g., finding food), but +there is no indication that they plan more than a few hours ahead." +"Humans are different. Although we do rely on instinct and emotions in +many situations, we also constantly analyze and evaluate information +from many feedback loops. We do this by running simulations sometimes +even beyond our own life span and even thousands of years into the +future. The point of running simulations is to evaluate various +possibilities to make the best decision to fulfill a goal. This occurs in the +prefrontal cortex, which allows us to simulate the future and evaluate +the possibilities in order to chart the best course of action. + +This ability evolved for several reasons. First, having the ability to +peer into the future has enormous evolutionary benefits, such as evading +predators and finding food and mates. Second, it allows us to choose +among several different outcomes and to select the best one." +"Third, the number of feedback loops explodes exponentially as we go +from Level 0 to Level I to Level II, so we need a “CEO” to evaluate all +these conflicting, competing messages. Instinct is no longer enough. +There has to be a central body that evaluates each of these feedback + +loops. This distinguishes human consciousness from that of the animals. +These feedback loops are evaluated, in turn, by simulating them into the +future to obtain the best outcome. If we didn’t have a CEO, chaos would +ensue and we would have sensory overload. + +A simple experiment can demonstrate this. David Eagleman describes +how you can take a male stickleback fish and have a female fish trespass +on its territory. The male gets confused, because it wants to mate with +the female, but it also wants to defend its territory. As a result, the male +stickleback fish will simultaneously attack the female while initiating +courtship behavior. The male is driven into a frenzy, trying to woo and +kill the female at the same time." +"This works for mice as well. Put an electrode in front of a piece of +cheese. If the mouse gets too close, the electrode will shock it. One +feedback loop tells the mouse to eat the cheese, but another one tells the +mouse to stay away and avoid being shocked. By adjusting the location +of the electrode, you can get the mouse to oscillate, torn between two +conflicting feedback loops. While a human has a CEO in its brain to +evaluate the pros and cons of the situation, the mouse, governed by two +conflicting feedback loops, goes back and forth. (This is like the proverb +about the donkey that starves to death because it is placed between two + + equal bales of hay.)" +"equal bales of hay.) + +Precisely how does the brain simulate the future? The human brain is +flooded by a large amount of sensory and emotional data. But the key is +to simulate the future by making causal links between events—that is, if +A happens, then B happens. But if B happens, then C and D might result. +This sets off a chain reaction of events, eventually creating a tree of +possible cascading futures with many branches. The CEO in the +prefrontal cortex evaluates the results of these causal trees in order to +make the ultimate decision. + +Let’s say you want to rob a bank. How many realistic simulations of +this event can you make? To do this, you have to think of the various +causal links involving the police, bystanders, alarm systems, relations +with fellow criminals, traffic conditions, the DA’s office, etc. For a +successful simulation of the robbery, hundreds of causal links may have +to be evaluated." +"It is also possible to measure this level of consciousness numerically. +Let’s say that a person is given a series of different situations like the one + +above and is asked to simulate the future of each. The sum total number +of causal links that the person can make for all these situations can be +tabulated. (One complication is that there are an unlimited number of +causal links that a person might make for a variety of conceivable +situations. To get around this complication, we divide this number by +the average number of causal links obtained from a large control group. +Like the IQ exam, one may multiply this number by 100. So a person’s +level of consciousness, for example, might be Level 111:100, meaning that +the person can simulate future events just like the average person.) + +We summarize these levels of consciousness in the following diagram: + +LEVELS OF CONSCIOUSNESS FOR DIFFERENT SPECIES + +LEVEL + +SPECIES + +PARAMETER + +BRAIN STRUCTURE + +0 + +| Plants + + | Temperature, sunshine + +None + +1" +"SPECIES + +PARAMETER + +BRAIN STRUCTURE + +0 + +| Plants + + | Temperature, sunshine + +None + +1 + +Reptiles + +j Space + +Brain stem + +II + +| Mammals + +| Social relations + +j Limbic system + +III + +j Humans + +| Time (esp. future) + +j Prefrontal cortex + +Space-time theory of consciousness. We define consciousness as the process of creating a model of the +world using +multiple feedback loops in various parameters (e.g., in space, time, and in relation to others), in order to +accomplish a +goal. Human consciousness is a particular type that involves mediating between these feedback loops +by simulating the + +future and evaluating the past." +"future and evaluating the past. + +(Notice that these categories correspond to the rough evolutionary +levels we find in nature—e.g., reptiles, mammals, and humans. However, +there are also gray areas, such as animals that might possess tiny aspects +of different levels of consciousness, animals that do some rudimentary +planning, or even single cells that communicate with one another. This +chart is meant only to give you the larger, global picture of how +consciousness is organized across the animal kingdom.) + +WHAT IS HUMOR? WHY DO WE HAVE EMOTIONS? + + All theories have to be falsifiable. The challenge for the space-time +theory of consciousness is to explain all aspects of human consciousness" +"in this framework. It can be falsified if there are patterns of thought that +cannot be brought into this theory. A critic might say that surely our +sense of humor is so quixotic and ephemeral that it is beyond +explanation. We spend a great deal of time laughing with our friends or +at comedians, yet it seems that humor has nothing to do with our +simulations of the future. But consider this. Much of humor, such as +telling a joke, depends on the punch line." +"When hearing a joke, we can’t help but simulate the future and +complete the story ourselves (even if we’re unaware that we’re doing +so). We know enough about the physical and social world that we can +anticipate the ending, so we burst out with laughter when the punch line +gives us a totally unexpected conclusion. The essence of humor is when +our simulation of the future is suddenly disrupted in surprising ways. +(This was historically important for our evolution since success depends, +in part, on our ability to simulate future events. Since life in the jungle is +full of unanticipated events, anyone who can foresee unexpected +outcomes has a better chance at survival. In this way, having a well- +developed sense of humor is actually one indication of our Level III +consciousness and intelligence; that is, the ability to simulate the future.)" +"For example, W. C. Fields was once asked a question about social +activities for youth. He was asked, “Do you believe in clubs for young +people?” He replied, “Only when kindness fails.” + +The joke has a punch line only because we mentally simulate a future +in which children have social clubs, while W. C. Fields simulates a +different future involving clubs as a weapon. (Of course, if a joke is +deconstructed, it loses its power, since we have already simulated +various possible futures in our minds.) + +This also explains what every comedian knows: timing is the key to +humor. If the punch line is delivered too quickly, then the brain hasn’t +had time to simulate the future, so there is no experience of the +unanticipated. If the punch line is delivered too late, the brain has +already had time to simulate various possible futures, so again the punch +line loses the element of surprise." +"(Humor has other functions, of course, such as bonding with fellow +members of our tribe. In fact, we use our sense of humor as a way to size +up the character of others. This, in turn, is essential to determine our +status within society. So in addition, laughter helps define our position + + in the social world, i.e., Level II consciousness.) + +WHY DO WE GOSSIP AND PLAY? + +Even seemingly trivial activities, such as engaging in idle gossip or +horsing around with our friends, must be explained in this framework. +(If a Martian were to visit a supermarket checkout line and view the +huge display of gossip magazines, it might conclude that gossip is the +main activity of humans. This observation would not be far off.)" +"Gossiping is essential for survival because the complex mechanics of +social interactions are constantly changing, so we have to make sense of +this ever-shifting social terrain. This is Level II consciousness at work. +But once we hear a piece of gossip, we immediately run simulations to +determine how this will affect our own standing in the community, +which moves us to Level III consciousness. Thousands of years ago, in +fact, gossip was the only way to obtain vital information about the tribe. +One’s very life often depended on knowing the latest gossip." +"Something as superfluous as “play” is also an essential feature of +consciousness. If you ask children why they like to play, they will say, +“Because it’s fun.” But that invites the next question: What is fun? +Actually, when children play, they are often trying to reenact complex +human interactions in simplified form. Human society is extremely +sophisticated, much too involved for the developing brains of young +children, so children run simplified simulations of adult society, playing +games such as doctor, cops and robber, and school. Each game is a +model that allows children to experiment with a small segment of adult +behavior and then run simulations into the future. (Similarly, when +adults engage in play, such as a game of poker, the brain constantly +creates a model of what cards the various players possess, and then +projects that model into the future, using previous data about people’s +personality, ability to bluff, etc. The key to games like chess, cards, and" +"personality, ability to bluff, etc. The key to games like chess, cards, and +gambling is the ability to simulate the future. Animals, which live +largely in the present, are not as good at games as humans are, +especially if they involve planning. Infant mammals do engage in a form +of play, but this is more for exercise, testing one another, practicing +future battles, and establishing the coming social pecking order rather" +"than simulating the future.) + +My space-time theory of consciousness might also shed light on + + another controversial topic: intelligence. Although IQ exams claim to +measure “intelligence,” IQ exams actually give no definition of +intelligence in the first place. In fact, a cynic may claim, with some +justification, that IQ is a measure of “how well you do on IQ exams,” +which is circular. In addition, IQ exams have been criticized for being +too culturally biased. In this new framework, however, intelligence may +be viewed as the complexity of our simulations of the future. Hence, a +master criminal, who may be a dropout and functionally illiterate and +score dismally low on an IQ exam, may also far outstrip the ability of the +police. Outwitting the cops may entail simply being able to run more +sophisticated simulations of the future. + +LEVEL I: STREAM OF CONSCIOUSNESS" +"LEVEL I: STREAM OF CONSCIOUSNESS + +Humans are probably alone on this planet in being able to operate on all +levels of consciousness. Using MRI scans, we can break down the +different structures involved in each level of consciousness." +"For us, Level I stream of consciousness is largely the interplay between +the prefrontal cortex and the thalamus. When taking a leisurely stroll in +the park, we are aware of the smells of the plants, the sensation of a +gentle breeze, the visual stimuli from the sun, and so on. Our senses send +signals to the spinal cord, the brain stem, and then to the thalamus, +which operates like a relay station, sorting out the stimuli and sending +them on to the various cortices of the brain. The images of the park, for +example, are sent to the occipital cortex in the back of the brain, while +the sense of touch from the wind is sent to the parietal lobe. The signals +are processed in appropriate cortices, and then sent to the prefrontal +cortex, where we finally become conscious of all these sensations. + +This is illustrated in Figure 7. + +LEVEL II: FINDING OUR PLACE IN SOCIETY" +"This is illustrated in Figure 7. + +LEVEL II: FINDING OUR PLACE IN SOCIETY + +While Level I consciousness uses sensations to create a model of our +physical location in space, Level II consciousness creates a model of our + +place in society. + +Let’s say we are going to an important cocktail party, in which people +essential to our job will be present. As we scan the room, trying to +identify people from our workplace, there is an intense interplay +between the hippocampus (which processes memories), the amygdala +(which processes emotions), and the prefrontal cortex (which puts all + + this information together). + +Figure 7. In Level I consciousness, sensory information travels through the brain stem, past the +thalamus, onto the various +cortices of the brain, and finally to the prefrontal cortex. Thus this stream of Level I consciousness is +created by the flow +of information from the thalamus to the prefrontal cortex, (illustration credit 2.1)" +"With each image, the brain automatically attaches an emotion, such as +happiness, fear, anger, or jealousy, and processes the emotion in the + +amygdala. + +If you spot your chief rival, whom you suspect of stabbing you in the +back, the emotion of fear is processed by the amygdala, which sends an +urgent message to the prefrontal cortex, alerting it to possible danger. At +the same time, signals are sent to your endocrine system to start +pumping adrenaline and other hormones into the blood, thereby +increasing your heartbeat and preparing you for a possible fight-or-flight +response. + +This is illustrated in Figure 8." +"This is illustrated in Figure 8. + +But beyond simply recognizing other people, the brain has the +uncanny ability to guess what other people are thinking about. This is +called the Theory of Mind, a theory first proposed by Dr. David Premack +of the University of Pennsylvania, which is the ability to infer the +thoughts of others. In any complex society, anyone with the ability to +correctly guess the intentions, motives, and plans of other people has a +tremendous survival advantage over those who can’t. The Theory of +Mind allows you to form alliances with others, isolate your enemies, and +solidify your friendships, which vastly increases your power and chances +of survival and mating. Some anthropologists even believe that the +mastery of the Theory of Mind was essential in the evolution of the +brain." +"Figure 8. Emotions originate and are processed in the limbic system. In Level II consciousness, we are +continually +bombarded with sensory information, but emotions are rapid-fire responses to emergencies from the +limbic system that + + do not need permission from the prefrontal cortex. The hippocampus is also important for processing +memories. So Level +II consciousness, at its core, involves the reaction of the amygdala, hippocampus, and prefrontal cortex, +(illustration + +credit 2.2) + +But how is the Theory of Mind accomplished? One clue came in 1996, +with the discovery of “mirror neurons” by Drs. Giacomo Rizzolatti, +Leonardo Fogassi, and Vittorio Gallese. These neurons fire when you are +performing a certain task and also when you see someone else +performing that same task. (Mirror neurons also fire for emotions as well +as physical acts. If you feel a certain emotion, and think another is +feeling that same emotion, then the mirror neurons will fire.)" +"Mirror neurons are essential for mimicry and also for empathy, giving + +us the ability not only to copy the complex tasks performed by others +but also to experience the emotions that person must be feeling. Mirror +neurons were thus probably essential for our evolution as human beings, +since cooperation is essential for holding the tribe together." +"Mirror neurons were first found in the premotor areas of monkey +brains. But since then, they have been found in humans in the prefrontal +cortex. Dr. V. S. Ramachandran believes that mirror neurons were +essential in giving us the power of self-awareness and concludes, “I +predict that mirror neurons will do for psychology what DNA did for +biology: they will provide a unifying framework and help explain a host +of mental abilities that have hitherto remained mysterious and +inaccessible to experiments.” (We should point out, however, that all +scientific results have to be tested and reconfirmed. There is no doubt +that certain neurons are performing this crucial behavior involved with +empathy, mimicry, etc., but there is some debate about the identity of +these mirror neurons. For example, some critics claim that perhaps these +behaviors are common to many neurons, and that there is not a single +class of neurons dedicated to this behavior.) + +LEVEL III: SIMULATING THE FUTURE" +"LEVEL III: SIMULATING THE FUTURE + +The highest level of consciousness, which is associated primarily with +Homo sapiens, is Level III consciousness, in which we take our model of +the world and then run simulations into the future. We do this by +analyzing past memories of people and events, and then simulating the + + future by making many causal links to form a “causal” tree. As we look +at the various faces at the cocktail party, we begin to ask ourselves +simple questions: How can this individual help me? How will the gossip +floating in the room play out in the future? Is anyone out to get me? + +Let’s say that you just lost your job and you are desperately looking +for a new one. In this case, as you talk to various people at the cocktail +party, your mind is feverishly simulating the future with each person +you talk to. You ask yourself, How can I impress this person? What +topics should I bring out to present my best case? Can he offer me a job?" +"Figure 9. Simulating the future, the heart of Level III consciousness, is mediated by the dorsolateral +prefrontal cortex, the +CEO of the brain, with competition between the pleasure center and the orbitofrontal cortex (which acts +to check our +impulses). This roughly resembles the outline given by Freud of the struggle between our conscience +and desires. The +actual process of simulating the future takes place when the prefrontal cortex accesses the memories of +the past in order + +to approximate future events, (illustration credit 2.3)" +"to approximate future events, (illustration credit 2.3) + +Recent brain scans have shed partial light on how the brain simulates +the future. These simulations are done mainly in the dorsolateral +prefrontal cortex, the CEO of the brain, using memories of the past. On +one hand, simulations of the future may produce outcomes that are +desirable and pleasurable, in which case the pleasure centers of the brain +light up (in the nucleus accumbens and hypothalamus). On the other +hand, these outcomes may also have a downside to them, so the +orbitofrontal cortex kicks in to warn us of possible dangers. There is a + +struggle, then, between different parts of the brain concerning the +future, which may have desirable and undesirable outcomes. Ultimately +it is the dorsolateral prefrontal cortex that mediates between these and +makes the final decisions. (See Figure 9.) (Some neurologists have +pointed out that this struggle resembles, in a crude way, the dynamics +between Freud’s ego, id, and superego.)" +"THE MYSTERY OF SELF-AWARENESS + + If the space-time theory of consciousness is correct, then it also gives us +a rigorous definition of self-awareness. Instead of vague, circular +references, we should be able to give a definition that is testable and +useful. We’ll define self-awareness as follows: + +Self-awareness is creating a model of the world and simulating + +the future in which you appear. + +Animals therefore have some self-awareness, since they have to know +where they are located if they are going to survive and mate, but it is +limited largely by instinct. + +When most animals are placed in front of a mirror, they either ignore +it or attack it, not realizing that it is an image of themselves. (This is +called the “mirror test,” which goes all the way back to Darwin.) +However, animals like elephants, the great apes, bottlenose dolphins, +orcas, and European magpies can figure out that the image they see in +the mirror represents themselves." +"Humans, however, take a giant step forward and constantly run future +simulations in which we appear as a principal actor. We constantly +imagine ourselves faced with different situations—going on a date, +applying for a job, changing careers—none of which is determined by +instinct. It is extremely difficult to stop your brain from simulating the +future, though elaborate methods have been devised (for instance, +meditation) to attempt to do so. + +Daydreaming, as an example, consists largely of our acting out +different possible futures to attain a goal. Since we pride ourselves in +knowing our limitations and strengths, it is not hard to put ourselves + +inside the model and hit the “play” button so we begin to act out +hypothetical scenarios, like being an actor in a virtual play. + +WHERE AM “I”?" +"WHERE AM “I”? + +There is probably a specific part of the brain whose job it is to unify the +signals from the two hemispheres to create a smooth, coherent sense of +self. Dr. Todd Heatherton, a psychologist at Dartmouth College, believes +that this region is located within the prefrontal cortex, in what is called +the medial prefrontal cortex. Biologist Dr. Carl Zimmer writes, “The +medial prefrontal cortex may play the same role for the self as the +hippocampus plays in memory ... [it] could be continually stitching +together a sense of who we are.” In other words, this may be the +gateway to the concept of “I,” the central region of the brain that fuses, + + integrates, and concocts a unified narrative of who we are. (This does +not mean, however, that the medial prefrontal cortext is the homunculus +sitting in our brain that controls everything.)" +"If this theory is true, then the resting brain, when we are idly +daydreaming about our friends and ourselves, should be more active +than normal, even when other parts of the brain’s sensory regions are +quiet. In fact, brain scans bear this out. Dr. Heatherton concludes, “Most +of the time we daydream—we think about something that happened to +us or what we think about other people. All this involves self-reflection.” + +The space-time theory says that consciousness is cobbled together +from many subunits of the brain, each competing with the others to +create a model of the world, and yet our consciousness feels smooth and +continuous. How can this be, when we all have the feeling that our “self” +is uninterrupted and always in charge?" +"In the previous chapter, we met the plight of split-brain patients, who +sometimes struggle with alien hands that literally have a mind of their +own. It does appear that there are two centers of consciousness living +within the same brain. So how does all this create the sense that we have +a unified, cohesive “self’ existing within our brains? + +I asked one person who may have the answer: Dr. Michael Gazzaniga, +who has spent several decades studying the strange behavior of split- +brain patients. He noticed that the left brain of split-brain patients, when" +"confronted with the fact that there seem to be two separate centers of +consciousness residing in the same skull, would simply make up strange +explanations, no matter how silly. He told me that, when presented with +an obvious paradox, the left brain will “confabulate” an answer to +explain inconvenient facts. Dr. Gazzaniga believes that this gives us the +false sense that we are unified and whole. He calls the left brain the +“interpreter,” which is constantly thinking up ideas to paper over +inconsistencies and gaps in our consciousness." +"For example, in one experiment, he flashed the word “red” to just the +left brain of a patient, and the word “banana” to just the right brain. +(Notice that the dominant left brain therefore does not know about the +banana.) Then the subject was asked to pick up a pen with his left hand +(which is governed by the right brain) and draw a picture. Naturally he +drew a picture of a banana. Remember that the right brain could do this, +because it had seen the banana, but the left brain had no clue that the +banana had been flashed to the right brain. + +Then he was asked why he had drawn the banana. Because only the +left brain controls speech, and because the left brain did not know" +"anything about a banana, the patient should have said, “I don’t know.” +Instead he said, “It is easiest to draw with this hand because this hand +can pull down easier.” Dr. Gazzaniga noted that the left brain was trying +to find some excuse for this inconvenient fact, even though the patient +was clueless about why his right hand drew the banana. + +Dr. Gazzaniga concludes, “It is the left hemisphere that engages in the +human tendency to find order in chaos, that tries to fit everything into a +story and put it into a context. It seems that it is driven to hypothesize +about the structure of the world even in the face of evidence that no +pattern exists.”" +"This is where our sense of a unified “self’ comes from. Although +consciousness is a patchwork of competing and often contradictory +tendencies, the left brain ignores inconsistencies and papers over +obvious gaps in order to give us a smooth sense of a single “I.” In other +words, the left brain is constantly making excuses, some of them +harebrained and preposterous, to make sense of the world. It is +constantly asking “Why?” and dreaming up excuses even if the question +has no answer. + +(There is probably an evolutionary reason that we evolved our split" +"(There is probably an evolutionary reason that we evolved our split + +brains. A seasoned CEO will often encourage his aides to take opposing +sides of an issue, to encourage thorough and thoughtful debate. +Oftentimes, the correct view emerges out of intense interaction with +incorrect ideas. Similarly, the two halves of the brain complement each +other, offering pessimistic/optimistic or analytical/holistic analysis of +the same idea. The two halves of the brain therefore play off each other. +Indeed, as we shall see, certain forms of mental illness may arise when +this interplay between the two brains goes awry.)" +"Now that we have a working theory of consciousness, the time has come +to utilize it to understand how neuroscience will evolve in the future. +There is a vast and remarkable set of experiments now being done in +neuroscience that are fundamentally altering the entire scientific +landscape. Using the power of electromagnetism, scientists can now +probe people’s thoughts, send telepathic messages, telekinetically control +objects around us, record memories, and perhaps enhance our +intelligence. + +Perhaps the most immediate and practical application of this new +technology is something once considered to be hopelessly impossible: +telepathy. + + BOOK II MIND OVER MATTER + +The brain, like it or not, is a machine. Scientists have come to +that conclusion, not because they are mechanistic killjoys, but +because they have amassed evidence that every aspect of +consciousness can be tied to the brain. + +—STEVEN PINKER + +3 TELEPATHY A PENNY FOR YOUR THOUGHTS" +"—STEVEN PINKER + +3 TELEPATHY A PENNY FOR YOUR THOUGHTS + +Harry Houdini, some historians believe, was the greatest magician +who ever lived. His breathtaking escapes from locked, sealed chambers +and death-defying stunts left audiences gasping. He could make people +disappear and then reemerge in the most unexpected places. And he +could read people’s minds. + +Or at least it seemed that way. + +Houdini took pains to explain that everything he did was an illusion, a +series of clever sleight-of-hand tricks. Mind reading, he would remind +people, was impossible. He was so outraged that unscrupulous magicians +would cheat wealthy patrons by performing cheap parlor tricks and +seances that he even went around the country exposing fakes by +pledging he could duplicate any feat of mind reading performed by these +charlatans. He was even on a committee organized by Scientific American +that offered a generous reward to anyone who could positively prove +they had psychic power. (No one ever picked up the reward.)" +"Houdini believed that telepathy was impossible. But science is proving +Houdini wrong. + +Telepathy is now the subject of intense research at universities around +the world, where scientists have already been able to use advanced +sensors to read individual words, images, and thoughts in a person’s +brain. This could alter the way we communicate with stroke and +accident victims who are “locked in” their bodies, unable to articulate +their thoughts except through blinks. But that’s just the start. Telepathy +might also radically change the way we interact with computers and the +outside world. + +Indeed, in a recent “Next 5 in 5 Forecast,” which predicts five +revolutionary developments in the next five years, IBM scientists claimed +that we will be able to mentally communicate with computers, perhaps + + replacing the mouse and voice commands. This means using the power +of the mind to call people on the phone, pay credit card bills, drive cars," +"make appointments, create beautiful symphonies and works of art, etc. +The possibilities are endless, and it seems that everyone—from computer +giants, educators, video game companies, and music studios to the +Pentagon—is converging on this technology." +"True telepathy, found in science-fiction and fantasy novels, is not +possible without outside assistance. As we know, the brain is electrical. +In general, anytime an electron is accelerated, it gives off +electromagnetic radiation. The same holds true for electrons oscillating +inside the brain, which broadcasts radio waves. But these signals are too +faint to be detected by others, and even if we could perceive these radio +waves, it would be difficult to make sense of them. Evolution has not +given us the ability to decipher this collection of random radio signals, +but computers can. Scientists have been able to get crude +approximations of a person’s thoughts using EEG scans. Subjects would +put on a helmet with EEG sensors and concentrate on certain pictures— +say, the image of a car. The EEG signals were then recorded for each +image and eventually a rudimentary dictionary of thought was created, +with a one-to-one correspondence between a person’s thoughts and the" +"with a one-to-one correspondence between a person’s thoughts and the +EEG image. Then, when a person was shown a picture of another car, +the computer would recognize the EEG pattern as being from a car." +"The advantage of EEG sensors is that they are noninvasive and quick. +You simply put a helmet containing many electrodes onto the surface of +the brain and the EEG can rapidly identify signals that change every +millisecond. But the problem with EEG sensors, as we have seen, is that +electromagnetic waves deteriorate as they pass through the skull, and it +is difficult to locate their precise source. This method can tell if you are +thinking of a car or a house, but it cannot re-create an image of the car. +That is where Dr. Jack Gallant’s work comes in. + +VIDEOS OF THE MIND + +The epicenter for much of this research is the University of California at +Berkeley, where I received my own Ph.D. in theoretical physics years +ago. I had the pleasure of touring the laboratory of Dr. Gallant, whose +group has accomplished a feat once considered to be impossible: +videotaping people’s thoughts. “This is a major leap forward + +reconstructing internal imagery. We are opening a window into the" +"reconstructing internal imagery. We are opening a window into the + + movies in our mind,” says Gallant. + +When I visited his laboratory, the first thing I noticed was the team of +young, eager postdoctoral and graduate students huddled in front of +their computer screens, looking intently at video images that were +reconstructed from someone’s brain scan. Talking to Gallant’s team, you +feel as though you are witnessing scientific history in the making." +"Gallant explained to me that first the subject lies flat on a stretcher, +which is slowly inserted headfirst into a huge, state-of-the-art MRI +machine, costing upward of $3 million. The subject is then shown +several movie clips (such as movie trailers readily available on +YouTube). To accumulate enough data, the subject has to sit motionless +for hours watching these clips, a truly arduous task. I asked one of the +postdocs, Dr. Shinji Nishimoto, how they found volunteers who were +willing to lie still for hours on end with only fragments of video footage +to occupy the time. He said the people in the room, the grad students +and postdocs, volunteered to be guinea pigs for their own research." +"As the subject watches the movies, the MRI machine creates a 3-D +image of the blood flow within the brain. The MRI image looks like a +vast collection of thirty thousand dots, or voxels. Each voxel represents a +pinpoint of neural energy, and the color of the dot corresponds to the +intensity of the signal and blood flow. Red dots represent points of large +neural activity, while blue dots represent points of less activity. (The +final image looks very much like thousands of Christmas lights in the +shape of the brain. Immediately you can see that the brain is +concentrating most of its mental energy in the visual cortex, which is +located at the back of the brain, while watching these videos.)" +"Gallant’s MRI machine is so powerful it can identify two to three +hundred distinct regions of the brain and, on average, can take snapshots +that have one hundred dots per region of the brain. (One goal for future +generations of MRI technology is to provide an even sharper resolution +by increasing the number of dots per region of the brain.) + +At first, this 3-D collection of colored dots looks like gibberish. But +after years of research, Dr. Gallant and his colleagues have developed a +mathematical formula that begins to find relationships between certain +features of a picture (edges, textures, intensity, etc.) and the MRI voxels. +For example, if you look at a boundary, you’ll notice it’s a region" +"separating lighter and darker areas, and hence the edge generates a +certain pattern of voxels. By having subject after subject view such a +large library of movie clips, this mathematical formula is refined, +allowing the computer to analyze how all sorts of images are converted +into MRI voxels. Eventually the scientists were able to ascertain a direct + + correlation between certain MRI patterns of voxels and features within +each picture." +"correlation between certain MRI patterns of voxels and features within +each picture. + +At this point, the subject is then shown another movie trailer. The +computer analyzes the voxels generated during this viewing and re¬ +creates a rough approximation of the original image. (The computer +selects images from one hundred movie clips that most closely resemble +the one that the subject just saw and then merges images to create a +close approximation.) In this way, the computer is able to create a fuzzy +video of the visual imagery going through your mind. Dr. Gallant’s +mathematical formula is so versatile that it can take a collection of MRI +voxels and convert it into a picture, or it can do the reverse, taking a +picture and then converting it to MRI voxels." +"I had a chance to view the video created by Dr. Gallant’s group, and it +was very impressive. Watching it was like viewing a movie with faces, +animals, street scenes, and buildings through dark glasses. Although you +could not see the details within each face or animal, you could clearly +identify the kind of object you were seeing." +"Not only can this program decode what you are looking at, it can also +decode imaginary images circulating in your head. Let’s say you are +asked to think of the Mona Lisa. We know from MRI scans that even +though you’re not viewing the painting with your eyes, the visual cortex +of your brain will light up. Dr. Gallant’s program then scans your brain +while you are thinking of the Mona Lisa and flips through its data files of +pictures, trying to find the closest match. In one experiment I saw, the +computer selected a picture of the actress Salma Hayek as the closest +approximation to the Mona Lisa. Of course, the average person can easily +recognize hundreds of faces, but the fact that the computer analyzed an +image within a person’s brain and then picked out this picture from +millions of random pictures at its disposal is still impressive." +"The goal of this whole process is to create an accurate dictionary that +allows you to rapidly match an object in the real world with the MRI +pattern in your brain. In general, a detailed match is very difficult and + +will take years, but some categories are actually easy to read just by +flipping through some photographs. Dr. Stanislas Dehaene of the College +de France in Paris was examining MRI scans of the parietal lobe, where +numbers are recognized, when one of his postdocs casually mentioned +that just by quickly scanning the MRI pattern, he could tell what number +the subject was looking at. In fact, certain numbers created distinctive +patterns on the MRI scan. He notes, “If you take 200 voxels in this area, +and look at which of them are active and which are inactive, you can +construct a machine-learning device that decodes which number is being +held in memory.”" +"This leaves open the question of when we might be able to have +picture-quality videos of our thoughts. Unfortunately, information is lost +when a person is visualizing an image. Brain scans corroborate this. +When you compare the MRI scan of the brain as it is looking at a flower +to an MRI scan as the brain is thinking about a flower, you immediately +see that the second image has far fewer dots than the first. So although +this technology will vastly improve in the coming years, it will never be +perfect. (I once read a short story in which a man meets a genie who +offers to create anything that the person can imagine. The man +immediately asks for a luxury car, a jet plane, and a million dollars. At +first, the man is ecstatic. But when he looks at these items in detail, he +sees that the car and the plane have no engines, and the image on the +cash is all blurred. Everything is useless. This is because our memories +are only approximations of the real thing.)" +"But given the rapidity with which scientists are beginning to decode +the MRI patterns in the brain, will we soon be able to actually read +words and thoughts circulating in the mind? + +READING THE MIND + +In fact, in a building next to Gallant’s laboratory, Dr. Brian Pasley and +his colleagues are literally reading thoughts—at least in principle. One of +the postdocs there, Dr. Sara Szczepanski, explained to me how they are +able to identify words inside the mind. + +The scientists used what is called ECOG (electrocorticogram) +technology, which is a vast improvement over the jumble of signals that + +EEG scans produce. ECOG scans are unprecedented in accuracy and +resolution, since signals are directly recorded from the brain and do not +pass through the skull. The flipside is that one has to remove a portion +of the skull to place a mesh, containing sixty-four electrodes in an eight- +by-eight grid, directly on top of the exposed brain." +"Luckily they were able to get permission to conduct experiments with +ECOG scans on epileptic patients, who were suffering from debilitating +seizures. The ECOG mesh was placed on the patients’ brains while open- +brain surgery was being performed by doctors at the nearby University +of California at San Francisco. + +As the patients hear various words, signals from their brains pass +through the electrodes and are then recorded. Eventually a dictionary is +formed, matching the word with the signals emanating from the + + electrodes in the brain. Later, when a word is uttered, one can see the +same electrical pattern. This correspondence also means that if one is +thinking of a certain word, the computer can pick up the characteristic +signals and identify it." +"With this technology, it might be possible to have a conversation that +takes place entirely telepathically. Also, stroke victims who are totally +paralyzed may be able to “talk” through a voice synthesizer that +recognizes the brain patterns of individual words. + +Not surprisingly, BMI (brain-machine interface) has become a hot +field, with groups around the country making significant breakthroughs. +Similar results were obtained by scientists at the University of Utah in +2011. They placed grids, each containing sixteen electrodes, over the +facial motor cortex (which controls movements of the mouth, lips, +tongue, and face) and Wernicke’s area, which processes information +about language." +"The person was then asked to say ten common words, such as “yes” +and “no,” “hot” and “cold,” “hungry” and “thirsty,” “hello” and “good¬ +bye,” and “more” and “less.” Using a computer to record the brain +signals when these words were uttered, the scientists were able to create +a rough one-to-one correspondence between spoken words and computer +signals from the brain. Later, when the patient voiced certain words, +they were able to correctly identify each one with an accuracy ranging +from 76 percent to 90 percent. The next step is to use grids with 121 +electrodes to get better resolution. + +In the future, this procedure may prove useful for individuals suffering +from strokes or paralyzing illnesses such as Lou Gehrig’s disease, who +would be able to speak using the brain-to-computer technique. + +TYPING WITH THE MIND" +"TYPING WITH THE MIND + +At the Mayo Clinic in Minnesota, Dr. Jerry Shih has hooked up epileptic +patients via ECOG sensors so they can learn how to type with the mind. +The calibration of this device is simple. The patient is first shown a +series of letters and is told to focus mentally on each symbol. A +computer records the signals emanating from the brain as it scans each +letter. As with the other experiments, once this one-to-one dictionary is +created, it is then a simple matter for the person to merely think of the +letter and for the letter to be typed on a screen, using only the power of +the mind. + +Dr. Shih, the leader of this project, says that the accuracy of his + + machine is nearly 100 percent. Dr. Shih believes that he can next create +a machine to record images, not just words, that patients conceive in +their minds. This could have applications for artists and architects, but +the big drawback of ECOG technology, as we have mentioned, is that it +requires opening up patients’ brains." +"Meanwhile, EEG typewriters, because they are noninvasive, are +entering the marketplace. They are not as accurate or precise as ECOG +typewriters, but they have the advantage that they can be sold over the +counter. Guger Technologies, based in Austria, recently demonstrated an +EEG typewriter at a trade show. According to their officials, it takes only +ten minutes or so for people to learn how to use this machine, and they +can then type at the rate of five to ten words per minute. + +TELEPATHIC DICTATION AND MUSIC + +The next step might be to transmit entire conversations, which could +rapidly speed up telepathic transmission. The problem, however, is that +it would require making a one-to-one map between thousands of words +and their EEG, MRI, or ECOG signals. But if one can, for example, +identify the brain signals of several hundred select words, then one" +"might be able to rapidly transmit words found in a common +conversation. This means that one would think of the words in entire +sentences and paragraphs of a conversation and a computer would print +them out. + +This could be extremely useful for journalists, writers, novelists, and +poets, who could simply think and have a computer take dictation. The +computer would also become a mental secretary. You would mentally +give instructions to the robo-secretary about a dinner, plane trip, or +vacation, and it would fill in all the details about the reservations." +"Not only dictation but also music may one day be transcribed in this +way. Musicians would simply hum a few melodies in their head and a +computer would print them out, in musical notation. To do this, you +would ask someone to mentally hum a series of notes, which would +generate certain electrical signals for each one. A dictionary would again +be created in this way, so that when you think of a musical note, the +computer would print it out in musical notation. + +In science fiction, telepaths often communicate across language +barriers, since thoughts are considered to be universal. However, this +might not be true. Emotions and feelings may well be nonverbal and +universal, so that one could telepathically send them to anyone, but + + rational thinking is so closely tied to language that it is very unlikely +that complex thoughts could be sent across language barriers. Words will +still be sent telepathically in their original language. + +TELEPATHY HELMETS" +"TELEPATHY HELMETS + +In science fiction, we also often encounter telepathy helmets. Put them +on, and—presto!—you can read other people’s minds. The U.S. Army, in +fact, has expressed interest in this technology. In a firefight, with +explosions going off and bullets whizzing overhead, a telepathy helmet +could be a lifesaver, since it can be difficult to communicate orders amid +the sound and fury of the battlefield. (I can personally testify to this. +Years ago, during the Vietnam War, I served in the U.S. Infantry at Fort +Benning, outside Atlanta, Georgia. During machine-gun training, the +sound of hand grenades and rounds of bullets going off on the battlefield +next to my ear was deafening; it was so intense I could not hear anything + +else. Later, there was a loud ringing in my ear that lasted for three full +days.) With a telepathy helmet, a soldier could mentally communicate +with his platoon amid all the thunder and noise." +"Recently, the army gave a $6.3 million grant to Dr. Gerwin Schalk at +Albany Medical College, but it knows that a fully functional telepathy +helmet is still years away. Dr. Schalk experiments with ECOG +technology, which, as we have seen, requires placing a mesh of +electrodes directly on top of the exposed brain. With this method, his +computers have been able to recognize vowels and thirty-six individual +words inside the thinking brain. In some of his experiments, he +approached 100 percent accuracy. But at present, this is still impractical +for the U.S. Army, since it requires removing part of the skull in the +clean, sterile environment of a hospital. And even then, recognizing +vowels and a handful of words is a far cry from sending urgent messages +to headquarters in a firefight. But his ECOG experiments have +demonstrated that it is possible to communicate mentally on the +battlefield." +"Another method is being explored by Dr. David Poeppel of New York +University. Instead of opening up the skulls of his subjects, he employs +MEG technology, using tiny bursts of magnetic energy rather than +electrodes to create electrical charges in the brain. Besides being +noninvasive, the advantage of MEG technology is that it can precisely +measure fleeting neural activity, in contrast to the slower MRI scans. In +his experiments, Poeppel has been able to successfully record electrical +activity in the auditory cortex when people think silently of a certain +word. But the drawback is that this recording still requires the use of + + large, table-size machines to generate a magnetic pulse. + +Obviously, one wants a method that is noninvasive, portable, and +accurate. Dr. Poeppel hopes his work with MEG technology will +complement the work being done using EEG sensors. But true telepathy +helmets are still many years away, because MEG and EEG scans lack +accuracy. + +MRI IN A CELL PHONE" +"MRI IN A CELL PHONE + +At present, we are hindered by the relatively crude nature of the existing + +instruments. But, as time goes by, more and more sophisticated +instruments will probe deeper into the mind. The next big breakthrough +may be MRI machines that are handheld." +"The reason why MRI machines have to be so huge right now is that +one needs a uniform magnetic field to get good resolution. The larger +the magnet, the more uniform one can make the field, and the better +accuracy one finds in the final pictures. However, physicists know the +exact mathematical properties of magnetic fields (they were worked out +by physicist James Clerk Maxwell back in the 1860S). In 1993 in +Germany, Dr. Bernhard Bliimich and his colleagues created the world’s +smallest MRI machine, which is the size of a briefcase. It uses a weak +and distorted magnetic field, but supercomputers can analyze the +magnetic field and correct for this so that the device produces realistic 3- +D pictures. Since computer power doubles roughly every two years, they +are now powerful enough to analyze the magnetic field created by the +briefcase-sized device and compensate for its distortion." +"As a demonstration of their machine, in 2006 Dr. Bliimich and his +colleagues were able to take MRI scans of Otzi, the “Iceman,” who was +frozen in ice about 5,300 years ago toward the end of the last ice age. +Because Otzi was frozen in an awkward position, with his arms spread +apart, it was difficult to cram him inside the small cylinder of a +conventional MRI machine, but Dr. Bliimich’s portable machine easily +took MRI photographs. + +These physicists estimate that, with increasing computer power, an +MRI machine of the future might be the size of a cell phone. The raw +data from this cell phone would be sent wirelessly to a supercomputer, +which would process the data from the weak magnetic field and then +create a 3-D image. (The weakness of the magnetic field is compensated +for by the increase in computer power.) This then could vastly accelerate +research. “Perhaps something like the Star Trek tricorder is not so far off" +"after all,” Dr. Bliimich has said. (The tricorder is a small, handheld +scanning device that gives an instant diagnosis of any illness.) In the +future, you may have more computer power in your medicine cabinet +than there is in a modern university hospital today. Instead of waiting to +get permission from a hospital or university to use an expensive MRI +machine, you could gather data in your own living room by simply +waving the portable MRI over yourself and then e-mailing the results to + +a lab for analysis." +"a lab for analysis. + +It could also mean that, at some point in the future, an MRI telepathy +helmet might be possible, with vastly better resolution than an EEG +scan. Here is how it may work in the coming decades. Inside the helmet, +there would be electromagnetic coils to produce a weak magnetic field +and radio pulses that probe the brain. The raw MRI signals would then +be sent to a pocketsize computer placed in your belt. The information +would then be radioed to a server located far from the battlefield. The +final processing of the data would be done by a supercomputer in a +distant city. Then the message would be radioed back to your troops on +the battlefield. The troops would hear the message either through +speakers or through electrodes placed in the auditory cortex of their +brains. + +DARPA AND HUMAN ENHANCEMENT" +"DARPA AND HUMAN ENHANCEMENT + +Given the costs of all this research, it is legitimate to ask: Who is paying +for it? Private companies have only recently shown interest in this +cutting-edge technology, but it’s still a big gamble for many of them to +fund research that may never pay off. Instead, one of the main backers is +DARPA, the Pentagon’s Defense Advanced Research Projects Agency, +which has spearheaded some of the most important technologies of the +twentieth century. + +DARPA was originally set up by President Dwight Eisenhower after +the Russians sent Sputnik into orbit in 1957 and shocked the world. +Realizing that the United States might quickly be outpaced by the +Soviets in high technology, Eisenhower hastily established this agency to +keep the country competitive with the Russians. Over the years, the +numerous projects it started grew so large that they became independent +entities by themselves. One of its first spinoffs was NASA." +"DARPA’s strategic plan reads like something from science fiction: its +“only charter is radical innovation.” The only justification for its +existence is “to accelerate the future into being.” DARPA scientists are +constantly pushing the boundaries of what is physically possible. As + + former DARPA official Michael Goldblatt says, they try not to violate the +laws of physics, “or at least not knowingly. Or at least not more than one + +per program.”" +"per program.” + +But what separates DARPA from science fiction is its track record, +which is truly astounding. One of its early projects in the 1960s was +Arpanet, which was a war-fighting telecommunications network that +would electronically connect scientists and officials during and after +World War III. In 1989, the National Science Foundation decided that, in +light of the breakup of the Soviet bloc, it was unnecessary to keep it a +secret, so it declassified this hush-hush military technology and +essentially gave codes and blueprints away for free. Arpanet would +eventually become the Internet. + +When the U.S. Air Force needed a way to guide its ballistic missiles in +space, DARPA helped create Project 57, a top-secret project that was +designed to place H-bombs on hardened Soviet missile silos in a +thermonuclear exchange. It would later become the foundation for the +Global Positioning System (GPS). Instead of guiding missiles, today it +guides lost motorists." +"DARPA has been a key player in a series of inventions that have +altered the twentieth and twenty-first centuries, including cell phones, +night-vision goggles, telecommunications advances, and weather +satellites. I have had a chance to interact with DARPA scientists and +officials on several occasions. I once had lunch with one of the agency’s +former directors at a reception filled with many scientists and futurists. I +asked him a question that had always bothered me: Why do we have to +rely on dogs to sniff our luggage for the presence of high explosives? +Surely our sensors are sensitive enough to pick up the telltale signature +of explosive chemicals. He replied that DARPA had actively looked into +this same question but had come up against some severe technical +problems. The olfactory sensors of dogs, he said, had evolved over +millions of years to be able to detect a handful of molecules, and that +kind of sensitivity is extremely difficult to match, even with our most" +"kind of sensitivity is extremely difficult to match, even with our most +finely tuned sensors. It’s likely that we will continue to rely on dogs at +airports for the foreseeable future." +"On another occasion, a group of DARPA physicists and engineers came +to a talk I gave about the future of technology. Later I asked them if they +had any concerns of their own. One concern, they said, was their public +image. Most people have never heard of DARPA, but some link it to +dark, nefarious government conspiracies, everything from UFO cover- + + ups, Area 51, and Roswell to weather control, etc. They sighed. If only +these rumors were true, they could certainly use help from alien +technology to jump-start their research!" +"With a budget of $3 billion, DARPA has now set its sights on the +brain-machine interface. When discussing the potential applications, +former DARPA official Michael Goldblatt pushes the boundary of the +imagination. He says, “Imagine if soldiers could communicate by +thought alone.... Imagine the threat of biological attack being +inconsequential. And contemplate, for a moment, a world in which +learning is as easy as eating, and the replacement of damaged body parts +as convenient as a fast-food drive-through. As impossible as these visions +sound or as difficult as you might think the task would be, these visions +are the everyday work of the Defense Sciences Office [a branch of +DARPA].”" +"Goldblatt believes that historians will conclude that the long-term +legacy of DARPA will be human enhancement, “our future historical +strength.” He notes that the famous army slogan “Be All You Can Be” +takes on a new meaning when contemplating the implications of human +enhancement. Perhaps it is no accident that Michael Goldblatt is pushing +human enhancement so vigorously at DARPA. His own daughter suffers +from cerebral palsy and has been confined to a wheelchair all her life. +Since she requires outside help, her illness has slowed her down, but she +has always risen above adversity. She is going to college and dreaming +of starting her own company. Goldblatt acknowledges that his daughter +is his inspiration. As Washington Post editor Joel Garreau has noted, +“What he is doing is spending untold millions of dollars to create what +might well be the next step in human evolution. And yet, it has occurred +to him that the technology he is helping create might someday allow his" +"to him that the technology he is helping create might someday allow his +daughter not just to walk, but to transcend.”" +"PRIVACY ISSUES + +When hearing of mind-reading machines for the first time, the average +person might be concerned about privacy. The idea that a machine +concealed somewhere may be reading our intimate thoughts without our +permission is unnerving. Human consciousness, as we have stressed, + +involves constantly running simulations of the future. In order for these +simulations to be accurate, we sometimes imagine scenarios that wade +into immoral or illegal territory, but whether or not we act on these +plans, we prefer to keep them private. + +For scientists, life would be easier if they could simply read people’s + + thoughts from a distance using portable devices (rather than by using +clumsy helmets or surgically opening up the skull), but the laws of +physics make this exceedingly difficult." +"When I asked Dr. Nishimoto, who works in Dr. Gallant’s Berkeley lab, +about the question of privacy, he smiled and replied that radio signals +degrade quite rapidly outside the brain, so these signals would be too +diffuse and weak to make any sense to anyone standing more than a few +feet away. (In school, we learned about Newton’s laws and that gravity +diminishes as the square of the distance, so that if you doubled your +distance from a star, the gravity field diminishes by a factor of four. But +magnetic fields diminish much faster than the square of the distance. +Most signals decrease by the cube or quartic of the distance, so if you +double the distance from an MRI machine, the magnetic field goes down +by a factor of eight or more.)" +"Furthermore, there would be interference from the outside world, +which would mask the faint signals coming from the brain. This is one +reason why scientists require strict laboratory conditions to do their +work, and even then they are able to extract only a few letters, words, or +images from the thinking brain at any given time. The technology is not +adequate to record the avalanche of thoughts that often circulate in our +brain as we simultaneously consider several letters, words, phrases, or +sensory information, so using these devices for mind reading as seen in +the movies is not possible today, and won’t be for decades to come." +"For the foreseeable future, brain scans will continue to require direct +access to the human brain in laboratory conditions. But in the highly +unlikely event that someone in the future finds a way to read thoughts +from a distance, there are still countermeasures you can take. To keep +your most important thoughts private, you might use a shield to block +brain waves from entering the wrong hands. This can be done with +something called a Faraday cage, invented by the great British physicist +Michael Faraday in 1836, although the effect was first observed by +Benjamin Franklin. Basically, electricity will rapidly disperse around a" +"metal cage, such that the electric field inside the cage is zero. To +demonstrate this, physicists (like myself) have entered a metallic cage on +which huge electrical bolts are fired. Miraculously, we are unscratched. +This is why airplanes can be hit by lightning bolts and not suffer +damage, and why cable wires are covered with metallic threads. +Similarly, a telepathy shield would consist of thin metal foil placed +around the brain. + +TELEPATHY VIA NANOPROBES IN THE BRAIN" +"TELEPATHY VIA NANOPROBES IN THE BRAIN + + There is another way to partially solve the privacy issue, as well as the +difficulty of placing ECOG sensors into the brain. In the future, it may be +possible to exploit nanotechnology, the ability to manipulate individual +atoms, to insert a web of nanoprobes into the brain that can tap into +your thoughts. These nanoprobes might be made of carbon nanotubes, +which conduct electricity and are as thin as the laws of atomic physics +allow. These nanotubes are made of individual carbon atoms arrayed in +a tube a few molecules thick. (They are the subject of intense scientific +interest, and are expected in the coming decades to revolutionize the +way scientists probe the brain.)" +"The nanoprobes would be placed precisely in those areas of the brain +devoted to certain activities. In order to convey speech and language, +they would be placed in the left temporal lobes. In order to process +visual images, they would be placed in the thalamus and visual cortex. +Emotions would be sent via nanoprobes in the amygdala and limbic +system. The signals from these nanoprobes would be sent to a small +computer, which would process the signals and wirelessly send +information to a server and then the Internet. + +Privacy issues would be partially solved, since you would completely +control when your thoughts are being sent over cables or the Internet. +Radio signals can be detected by any bystander with a receiver, but +electrical signals sent along a cable cannot. The problem of opening up +the skull to use messy ECOG meshes is also solved, because the +nanoprobes can be inserted via microsurgery." +"Some science-fiction writers have conjectured that when babies are +born in the future, these nanoprobes might be painlessly implanted, so + +that telepathy becomes a way of life for them. In Star Trek, for example, +implants are routinely placed into the children of the Borg at birth so +that they can telepathically communicate with others. These children +cannot imagine a world where telepathy does not exist. They take it for +granted that telepathy is the norm. + +Because these nanoprobes are tiny, they would be invisible to the +outside world, so there would be no social ostracism. Although society +might be repulsed at the idea of inserting probes permanently into the +brain, these science-fiction writers assume that people will get used to +the idea because the nanoprobes would be so useful, just like test-tube +babies have been accepted by society today after the initial controversy +surrounding them. + +LEGAL ISSUES" +"LEGAL ISSUES + + For the foreseeable future, the question is not whether someone will be +able to read our thoughts secretly from a remote, concealed device, but +whether we will willingly allow our thoughts to be recorded. What +happens, then, if some unscrupulous person gets unauthorized access to +those files? This raises the issue of ethics, since we would not want our +thoughts to be read against our will. Dr. Brian Pasley says, “There are +ethical concerns, not with the current research, but with the possible +extensions of it. There has to be a balance. If we are somehow able to +decode someone’s thoughts instantaneously that might have great +benefits for the thousands of severely disabled people who are unable to +communicate right now. On the other hand, there are great concerns if +this were applied to people who didn’t want that.”" +"Once it becomes possible to read people’s minds and make recordings, +a host of other ethical and legal questions will arise. This happens +whenever any new technology is introduced. Historically it often takes +years before the law is fully able to address their implications. + +For instance, copyright laws may have to be rewritten. What happens +if someone steals your invention by reading your thoughts? Can you +patent your thoughts? Who actually owns the idea? + +Another problem occurs if the government is involved. As John Perry +Barlow, poet and lyricist for the Grateful Dead, once said, “Relying on" +"the government to protect your privacy is like asking a peeping tom to +install your window blinds.” Would the police be allowed to read your +thoughts when you are being interrogated? Already courts have been +ruling on cases where an alleged criminal refused to submit his DNA as +evidence. In the future, will the government be allowed to read your +thoughts without your consent, and if so, will they be admissible in +court? How reliable would they be? In the same way that MRI lie +detectors measure only increased brain activity, it’s important to note +that thinking about a crime and actually committing one are two +different things. During cross-examination, a defense lawyer might argue +that these thoughts were just random musings and nothing more." +"Another gray area concerns the rights of people who are paralyzed. If +they are drafting a will or legal document, can a brain scan be sufficient +to create a legal document? Assume that a totally paralyzed person has a +sharp, active mind and wants to sign a contract or manage his funds. Are +these documents legal, given that the technology may not be perfect? + +There is no law of physics that can resolve these ethical questions. +Ultimately, as this technology matures, these issues will have to be + + settled in court by judges and juries." +"settled in court by judges and juries. + +Meanwhile, governments and corporations might have to invent new +ways to prevent mental espionage. Industrial espionage is already a +multimillion-dollar industry, with governments and corporations +building expensive “safe rooms” that have been scanned for bugs and +listening devices. In the future (assuming that a method can be devised +to listen to brain waves from a distance), safe rooms may have to be +designed so that brain signals are not accidentally leaked to the outside +world. These safe rooms would be surrounded by metallic walls, which +would form a Faraday cage shielding the interior of the room from the +outside world." +"Every time a new form of radiation has been exploited, spies have +tried to use it for espionage, and brain waves are probably no exception. +The most famous case involved a tiny microwave device hidden in the +Great Seal of the United States in the U.S. embassy in Moscow. From +1945 until 1952, it was transmitting top-secret messages from U.S. +diplomats directly to the Soviets. Even during the Berlin Crisis of 1948 +and the Korean War, the Soviets used this bug to decipher what the +United States was planning. It might have continued to leak secrets even" +"today, changing the course of the Cold War and world history, but it was +accidentally discovered when a British engineer heard secret +conversations on an open radio band. U.S. engineers were shocked when +they picked apart the bug; they failed to detect it for years because it +was passive, requiring no energy source. (The Soviets cleverly evaded +detection because the bug was energized by microwave beams from a +remote source.) It is possible that future espionage devices will be made +to intercept brain waves as well. + +Although much of this technology is still primitive, telepathy is slowly +becoming a fact of life. In the future, we may interact with the world via +the mind. But scientists want to go beyond just reading the mind, which +is passive. They want to take an active role—to move objects with the +mind. Telekinesis is a power usually ascribed to the gods. It is the divine +power to shape reality to your wishes. It is the ultimate expression of our +thoughts and desires." +"We will soon have it. + +It is the business of the future to be dangerous.... The major +advances in civilization are processes that all but wreck the +societies in which they occur. + + —ALFRED NORTH WHITEHEAD + +4 TELEKINESIS MIND CONTROLLING MATTER + +Cathy Hutchinson is trapped inside her body. + +She was paralyzed fourteen years ago by a massive stroke. A +quadriplegic, she is like thousands of “locked-in” patients who have lost +control over most of their muscles and bodily functions. Most of the day, +she lies helpless, requiring continual nursing care, yet her mind is clear. +She is a prisoner in her own body." +"But in May 2012, her fortunes changed radically. Scientists at Brown +University placed a tiny chip on top of her brain, called Braingate, which +is connected by wires to a computer. Signals from her brain are relayed +through the computer to a mechanical robotic arm. By simply thinking, +she gradually learns to control the motion of the arm so that it can, for +instance, grab a bottled drink and bring it to her mouth. For the first +time, she is able to have some control of the world around her." +"Because she is paralyzed and cannot talk, she had to communicate her +excitement by making eye movements. A device tracks her eyes and then +translates her movements into a typed message. When she was asked +how she felt, after years of being imprisoned inside a shell called her +body, she replied, “Ecstatic!” Looking forward to the day when her other +limbs are connected to her brain via computer, she added, “I would love +to have a robotic leg support.” Before her stroke, she loved to cook and +tend her garden. “I know that someday this will happen again,” she +added. At the rate at which the field of cyber prosthetics is moving, she +might have her wish soon." +"Professor John Donoghue and his colleagues at Brown University and +also at the University of Utah have created a tiny sensor that acts like a +bridge to the outside world for those who can no longer communicate. +When I interviewed him, he told me, “We have taken a tiny sensor, the +size of a baby aspirin, or four millimeters, and implanted it onto the +surface of the brain. Because of ninety-six little ‘hairs’ or electrodes that +pick up brain impulses, it can pick up signals of your intention to move + +your arm. We target the arm because of its importance.” Because the +motor cortex has been carefully mapped over the decades, it is possible +to place the chip directly on top of the neurons that control specific +limbs." +"The key to Braingate lies in translating neural signals from the chip +into meaningful commands that can move objects in the real world, +starting with the cursor of a computer screen. Donoghue told me that he +does this by asking the patient to imagine moving the cursor of a +computer screen in a certain way, e.g., moving it to the right. It takes +only a few minutes to record the brain signals corresponding to this task. +In this way, the computer recognizes that whenever it detects a brain +signal like that, it should move the cursor to the right. + +Then, whenever that person thinks of moving the cursor to the right, +the computer actually moves the cursor in that direction. In this way, +there is a one-to-one map between certain actions that the patient +imagines and the actual action itself. A patient can immediately start to +control the movement of the cursor, practically on the first try." +"Braingate opens the door to a new world of neuroprosthetics, allowing +a paralyzed person to move artificial limbs with the mind. In addition, it +lets the patient communicate directly with their loved ones. The first +version of this chip, tested in 2004, was designed so that paralyzed +patients could communicate with a laptop computer. Soon afterward, +these patients were surfing the web, reading and writing e-mails, and +controlling their wheelchairs. + +More recently, the cosmologist Stephen Hawking had a +neuroprosthetic device attached to his glasses. Like an EEG sensor, it can +connect his thoughts to a computer so that he can maintain some contact +with the outside world. It is rather primitive, but eventually devices +similar to it will become much more sophisticated, with more channels +and greater sensitivity." +"All this, Dr. Donoghue told me, could have a profound impact on the +lives of these patients: “Another useful thing is that you can connect this +computer to any device—a toaster, a coffee maker, an air conditioner, a +light switch, a typewriter. It’s really quite easy to do these things these +days, and it’s very inexpensive. For a quadriplegic who can’t get around, +they will be able to change the TV channel, turn the lights on, and do all +those things without anybody coming into the room and doing it for + +them.” Eventually, they will be able to do anything a normal person can +do, via computers. + +FIXING SPINAL CORD INJURIES + +A number of other groups are entering the fray. Another breakthrough +was made by scientists at Northwestern University who have connected" +"a monkey’s brain directly to his own arm, bypassing an injured spinal +cord. In 1995, there was the sad story of Christopher Reeve, who soared +into outer space in the Superman movies but was completely paralyzed +due to an injury to his spinal cord. Unfortunately, he was thrown off a +horse and landed on his neck, so the spinal cord was damaged just +beneath his head. If he had lived longer, he might have seen the work of +scientists who want to use computers to replace broken spinal cords. In +the United States alone, more than two hundred thousand people have +some form of spinal cord injury. In an earlier age, these individuals +might have died soon after the accident, but because of advances in +acute trauma care, the number of people who survive these sorts of +injuries has actually grown in recent years. We are also haunted by the +images of thousands of wounded warriors who were victims of roadside +bombs in Iraq and Afghanistan. And if you include the number of" +"bombs in Iraq and Afghanistan. And if you include the number of +patients paralyzed by strokes and other illnesses, like amyotropic lateral +sclerosis (ALS), the number of patients swells to two million." +"The scientists at Northwestern used a one-hundred-electrode chip, +which was placed directly on the brain of a monkey. The signals from +the brain were carefully recorded as the monkey grasped a ball, lifted it, +and released it into a tube. Since each task corresponds to a specific +firing of neurons, the scientists could gradually decode these signals. + +When the monkey wanted to move his arm, the signals were processed +by a computer using this code, and, instead of sending the messages to a +mechanical arm, they sent the signals directly to the nerves of the +monkey’s real arm. “We are eavesdropping on the natural electrical +signals from the brain that tell the arm and hand how to move, and +sending those signals directly to the muscles,” says Dr. Lee Miller. + +By trial and error, the monkey learned to coordinate the muscles in his +arm. “There is a process of motor learning that is very similar to the" +"process you go through when you learn to use a new computer, mouse, +or a different tennis racquet,” adds Dr. Miller. + +(It is remarkable that the monkey was able to master so many motions +of his arm, given the fact that there are only one hundred electrodes on +this brain chip. Dr. Miller points out that millions of neurons are +involved in controlling the arm. The reason that one hundred electrodes +can give a reasonable approximation to the output of millions of neurons +is that the chip connects to the output neurons, after all the complex +processing has already been done by the brain. With the sophisticated +analysis out of the way, the one hundred electrodes are responsible +simply for feeding that information to the arm.) + +This device is one of several being devised at Northwestern that will" +"This device is one of several being devised at Northwestern that will + + allow patients to bypass their injured spinal cords. Another neural +prosthesis uses the motion of the shoulders to control the arm. An +upward shrug causes the hand to close. A downward shrug causes the +hand to open. The patient also has the ability to curl his fingers around +an object like a cup, or manipulate a key that is grasped between the +thumb and index finger. + +Dr. Miller concludes, “This connection from brain to muscles might +someday be used to help patients paralyzed due to spinal cord injury +perform activities of daily living and achieve greater independence.” + +REVOLUTIONIZING PROSTHETICS" +"REVOLUTIONIZING PROSTHETICS + +Much of the funding driving these remarkable developments comes from +a DARPA project called Revolutionizing Prosthetics, a $150 million +effort that has been bankrolling these efforts since 2006. One of the +driving forces behind Revolutionizing Prosthetics is retired U.S. Army +colonel Geoffrey Ling, who is a neurologist with several tours of duty in +Iraq and Afghanistan. He was appalled at the human carnage he +witnessed on the battlefield caused by roadside bombs. In previous wars, +many of these brave service members would have died on the spot. But +today, with helicopters and an extensive medical evacuation +infrastructure, many of them survive but still suffer from serious bodily +injuries. More than 1,300 service members have lost limbs after coming +back from the Middle East." +"Dr. Ling asked himself whether there was a scientific way to replace +these lost limbs. Backed by funding from the Pentagon, he asked his staff +to come up with concrete solutions within five years. When he made that +request, he was met with incredulity. He recalled, “They thought we +were crazy. But it’s in insanity that things happen.” + +Spurred into action by Dr. Ling’s boundless enthusiasm, his crew has +created miracles in the laboratory. For example, Revolutionary +Prosthetics funded scientists at the Johns Hopkins Applied Physics +Laboratory who have created the most advanced mechanical arm on +Earth, which can duplicate nearly all the delicate motions of the fingers, +hand, and arm in three dimensions. It is the same size and has the same +strength and agility as a real arm. Although it is made of steel, if you +covered it up with flesh-colored plastic, it would be nearly +indistinguishable from a real arm." +"This arm was attached to Jan Sherman, a quadriplegic who had +suffered from a genetic disease that damaged the connection between +her brain and her body, leaving her completely paralyzed from the neck + + down. At the University of Pittsburgh, electrodes were placed directly on +top of her brain, which were then connected to a computer and then to a +mechanical arm. Five months after surgery to attach the arm, she +appeared on 60 Minutes. Before a national audience, she cheerfully used +her new arm to wave, greet the host, and shake his hand. She even gave +him a fist bump to show how sophisticated the arm was. + +Dr. Ling says, “In my dream, we will be able to take this into all sorts +of patients, patients with strokes, cerebral palsy, and the elderly.” + +TELEKINESIS IN YOUR LIFE" +"TELEKINESIS IN YOUR LIFE + +Not only scientists but also entrepreneurs are looking at brain-machine +interface (BMI). They wish to incorporate many of these dazzling +inventions as a permanent part of their business plans. BMI has already +penetrated the youth market, in the form of video games and toys that +use EEG sensors so that you can control objects with the mind in both +virtual reality and the real world. In 2009, NeuroSky marketed the first +toy, Mindflex, specifically designed to use EEG sensors to move a ball +through a maze. Concentrating while wearing the Mindflex EEG device + +increases the speed of a fan within the maze and propels a tiny ball +down a pathway." +"increases the speed of a fan within the maze and propels a tiny ball +down a pathway. + +Mind-controlled video games are also blossoming. Seventeen hundred +software developers are working with NeuroSky, many of them on the +company’s $129 million Mindwave Mobile headset. These video games +use a small, portable EEG sensor wrapped around your forehead that +allows you to navigate in virtual reality, where the movements of your +avatar are controlled mentally. As you maneuver your avatar on the +video screen, you can fire weapons, evade enemies, rise to new levels, +score points, etc., as in an ordinary video game, except that everything is +hands-free. + +“There’s going to be a whole ecosystem of new players, and NeuroSky +is very well positioned to be like the Intel of this new industry,” claims +Alvaro Fernandez of SharpBrains, a market research firm." +"Besides firing virtual weapons, the EEG helmet can also detect when +your attention begins to flatten out. NeuroSky has been getting inquiries +from companies concerned about injuries to workers who lose +concentration while operating a dangerous machine or who fall asleep at +the wheel. This technology could be a lifesaver, alerting the worker or +driver that he is losing his focus. The EEG helmet would set off an alarm +when the wearer dozes off. (In Japan, this headset is already creating a + + fad among partygoers. The EEG sensors look like cat ears when you put +them on your head. The ears suddenly rise when your attention is +focused and then flatten out when it fades. At parties, people can express +romantic interest just by thinking, so you know if you are impressing +someone.)" +"But perhaps the most novel applications of this technology are being +pursued by Dr. Miguel Nicolelis of Duke University. When I interviewed +him, he told me that he thinks he can duplicate many of the devices +found only in science fiction. + +SMART HANDS AND MIND MELDS + +Dr. Nicolelis has shown that this brain-machine interface can be done +across continents. He places a monkey on a treadmill. A chip is +positioned on the monkey’s brain, which is connected to the Internet. On + +the other side of the planet, in Kyoto, Japan, signals from the monkey +are used to control a robot that can walk. By walking on the treadmill in +North Carolina, the monkey controls a robot in Japan, which executes +the same walking motion. Using only his brain sensors and the reward of +a food pellet, Dr. Nicolelis has trained these monkeys to control a +humanoid robot called CB-1 halfway around the world." +"He is also tackling one of the main problems with brain-machine +interface: the lack of feeling. Today’s prosthetic hands don’t have a sense +of touch, and hence they feel foreign; because there’s no feedback, they +might accidentally crush someone’s fingers while engaging in a +handshake. Picking up an eggshell with a mechanical arm would be +nearly impossible. + +Nicolelis hopes to circumvent this problem by having a direct brain-to- +brain interface. Messages would be sent from the brain to a mechanical +arm that has sensors, which would then send messages directly back to +the brain, thereby bypassing the stem altogether. This brain-machine- +brain interface (BMBI) could enable a clean, direct feedback mechanism +to allow for the sensation of touch." +"Dr. Nicolelis started by connecting the motor cortex of rhesus monkeys +to mechanical arms. These mechanical arms have sensors on them, +which then send signals back to the brain by electrodes connected to the +somatosensory cortex (which registers the sensation of touch). The +monkeys were given a reward after every successful trial; they learned +how to use this apparatus within four to nine trials. + + To do this, Dr. Nicolelis had to invent a new code that would +represent different surfaces (which were rough or smooth). “After a +month of practice,” he told me, “this part of the brain learns this new +code, and starts to associate this new artificial code that we created with +different textures. So this is the first demonstration that we can create a +sensory channel” that can simulate sensations of the skin." +"I mentioned to him that this idea sounds like the “holodeck” of Star +Trek, where you wander in a virtual world but feel sensations when you +bump into virtual objects, just as if they were real. This is called “haptic +technology,” which uses digital technology to simulate the sense of +touch. Nicolelis replied, “Yes, I think this is the first demonstration that +something like the holodeck will be possible in the near future.” + +The holodeck of the future might use a combination of two + +technologies. First, people in the holodeck would wear Internet contact +lenses, so that they would see an entirely new virtual world everywhere +they looked. The scenery in your contact lens would change instantly +with the push of a button. And if you touched any object in this world, +signals sent into the brain would simulate the sensation of touch, using +BMBI technology. In this way, objects in the virtual world you see inside +your contact lens would feel solid." +"Brain-to-brain interface would make possible not only haptic +technology, but also an “Internet of the mind,” or brain-net, with direct +brain-to-brain contact. In 2013, Dr. Nicolelis was able to accomplish +something straight out of Star Trek, a “mind meld” between two brains. +He started with two groups of rats, one at Duke University, the other in +Natal, Brazil. The first group learned to press a lever when seeing a red +light. The second group learned to press a lever when their brains were +stimulated by a signal sent via an implant. Their reward for pressing the +lever was a sip of water. Then Dr. Nicolelis connected the motor cortices +of the brains of both groups via a fine wire through the Internet." +"When the first group of rats saw the red light, a signal was sent over +the Internet to Brazil to the second group, which then pressed the lever. +In seven out of ten trials, the second group of rats correctly responded to +the signals sent by the first group. This was the first demonstration that +signals could be transferred and also interpreted correctly between two +brains. It’s still a far cry from the mind meld of science fiction, where +two minds merge into one, because this is still primitive and the sample +size is small, but it is a proof of principle that a brain-net might be +possible. + +In 2013, the next important step was taken when scientists went +beyond animal studies and demonstrated the first direct human brain-to- + + brain communication, with one human brain sending a message to +another via the Internet." +"brain communication, with one human brain sending a message to +another via the Internet. + +This milestone was achieved at the University of Washington, with +one scientist sending a brain signal (move your right arm) to another +scientist. The first scientist wore an EEG helmet and played a video +game. He fired a cannon by imagining moving his right arm, but was +careful not to move it physically. + +The signal from the EEG helmet was sent over the Internet to another +scientist, who was wearing a transcranial magnetic helmet carefully + +placed over the part of his brain that controlled his right arm. When the +signal reached the second scientist, the helmet would send a magnetic +pulse into his brain, which made his right arm move involuntarily, all by +itself. Thus, by remote control, one human brain could control the +movement of another." +"This breakthrough opens up a number of possibilities, such as +exchanging nonverbal messages via the Internet. You might one day be +able to send the experience of dancing the tango, bungee jumping, or +skydiving to the people on your e-mail list. Not just physical activity, but +emotions and feelings as well might be sent via brain-to-brain +communication." +"Nicolelis envisions a day when people all over the world could +participate in social networks not via keyboards, but directly through +their minds. Instead of just sending e-mails, people on the brain-net +would be able to telepathically exchange thoughts, emotions, and ideas +in real time. Today a phone call conveys only the information of the +conversation and the tone of voice, nothing more. Video conferencing is +a bit better, since you can read the body language of the person on the +other end. But a brain-net would be the ultimate in communications, +making it possible to share the totality of mental information in a +conversation, including emotions, nuances, and reservations. Minds +would be able to share their most intimate thoughts and feelings. + +TOTAL IMMERSION ENTERTAINMENT" +"TOTAL IMMERSION ENTERTAINMENT + +Developing a brain-net may also have an impact on the multibillion- +dollar entertainment industry. Back in the 1920s, the technology of tape¬ +recording sound as well as light was perfected. This set off a +transformation in the entertainment industry as it made the transition +from silent movies to the “talkies.” This basic formula of combining +sound and sight hasn’t changed much for the past century. But in the + + future, the entertainment industry may make the next transition, +recording all five senses, including smell, taste, and touch, as well as the +full range of emotions. Telepathic probes would be able to handle the +full range of senses and emotions that circulate in the brain, producing a +complete immersion of the audience in the story. Watching a romantic" +"movie or an action thriller, we would be swimming in an ocean of +sensations, as if we were really there, experiencing all the rush of +feelings and the emotions of the actors. We would smell the perfume of +the heroine, feel the terror of the victims in a horror movie, and relish +the vanquishing of the bad guys." +"This immersion would involve a radical shift in how movies are made. +First, actors would have to be trained to act out their roles with +EEG/MRI sensors and nanoprobes recording their sensations and +emotions. (This would place an added burden on the actors, who would +have to act out each scene by simulating all five senses. In the same way +that some actors could not make the transition from silent movies to the +talkies, perhaps a new generation of actors will emerge who can act out +scenes with all five senses.) Editing would require not just cutting and +splicing film, but also combining tapes of the various sensations within +each scene. And finally the audience, as they sit in their seats, would +have all these electrical signals fed into their brains. Instead of 3-D +glasses, the audience would wear brain sensors of some sort. Movie +theaters would also have to be retrofitted to process this data and then +send it to the people in the audience. + +CREATING A BRAIN-NET" +"CREATING A BRAIN-NET + +Creating a brain-net that can transmit such information would have to +be done in stages. The first step would be inserting nanoprobes into +important parts of the brain, such as the left temporal lobe, which +governs speech, and the occipital lobe, which governs vision. Then +computers would analyze these signals and decode them. This +information in turn could be sent over the Internet by fiber-optic cables. + +More difficult would be to insert these signals back into another +person’s brain, where they could be processed by the receiver. So far, +progress in this area has focused only on the hippocampus, but in the +future it should be possible to insert messages directly into other parts of +the brain corresponding to our sense of hearing, light, touch, etc. So +there is plenty of work to be done as scientists try to map the cortices of +the brain involved in these senses. Once these cortices have been +mapped—such as the hippocampus, which we’ll discuss in the next" +"chapter—it should be possible to insert words, thoughts, memories, and +experiences into another brain. + +Dr. Nicolelis writes, “It is not inconceivable that our human progeny +may indeed muster the skills, technology, and ethics needed to establish +a functional brain-net, a medium through which billions of human +beings consensually establish temporary direct contacts with fellow +human beings through thought alone. What such a colossus of collective +consciousness may look like, feel like, or do, neither I nor anyone in our +present time can possibly conceive or utter.” + +THE BRAIN-NET AND CIVILIZATION" +"A brain-net may even change the course of civilization itself. Each time a +new communication system has been introduced, it has irrevocably +accelerated changes in society, lifting us from one era to the next. In +prehistoric times, for thousands of years our ancestors were nomads +wandering in small tribes, communicating with one another through +body language and grunts. The coming of language allowed us for the +first time to communicate symbols and complex ideas, which facilitated +the rise of villages and eventually cities. Within the last few thousand +years, written language has enabled us to accumulate knowledge and +culture across generations, allowing for the rise of science, the arts, +architecture, and huge empires. The coming of the telephone, radio, and +TV extended the reach of communication across continents. The Internet +now makes possible the rise of a planetary civilization that will link all +the continents and peoples of the world. The next giant step might be a" +"the continents and peoples of the world. The next giant step might be a +planetary brain-net, in which the full spectrum of senses, emotions, +memories, and thoughts are exchanged on a global scale." +"‘WE WILL BE PART OF THEIR OPERATING SYSTEM' + +When I interviewed Dr. Nicolelis, he told me that he became interested +in science at an early age while growing up in his native Brazil. He +remembers watching the Apollo moon shot, which captured the world’s +attention. To him, it was an amazing feat. And now, he told me, his own +“moon shot” is making it possible to move any object with the mind. + +He became interested in the brain while still in high school, where he +came across a 1964 book by Isaac Asimov titled The Human Brain. But he +was disappointed by the end of the book. There was no discussion about +how all these structures interacted with one another to create the mind + + (because no one knew the answer back then). It was a life-changing +moment and he realized that his own destiny might lie in trying to +understand the secrets of the brain." +"About ten years ago, he told me, he began to look seriously into doing +research on his childhood dream. He started by taking a mouse and +letting it control a mechanical device. “We placed sensors into the mouse +which read the electrical signals from the brain. Then we transmitted +these signals to a little robotic lever that could bring water from a +fountain back to the mouse’s mouth. So the animal had to learn how to +mentally move the robotic device to bring the water back. That was the +first-ever demonstration that you could connect an animal to a machine +so that it could operate a machine without moving its own body,” he +explained to me." +"Today he can analyze not just fifty but one thousand neurons in the +brain of a monkey, which can reproduce various movements in different +parts of the monkey’s body. Then the monkey can control various +devices, such as mechanical arms, or even virtual images in cyberspace. +“We even have a monkey avatar that can be controlled by the monkey’s +thoughts without the monkey making any movement,” he told me. This +is done by having the monkey watch a video in which he sees an avatar +that represents his body. Then, by mentally commanding his body to +move, the monkey makes the avatar move in the corresponding way. + +Nicolelis envisions a day in the very near future when we will play +video games and control computers and appliances with our minds. “We + +will be part of their operating system. We will be immersed in them with +mechanisms that are very similar to the experiments that I am +describing.” + +EXOSKELETONS" +"EXOSKELETONS + +The next undertaking for Dr. Nicolelis is the Walk Again Project. Its goal +is nothing less than a complete exoskeleton for the body controlled by +the mind. At first, an exoskeleton conjures up an image of something +from the Iron Man movies. Actually, it is a special suit that encases the +entire body so that the arms and legs can move via motors. He calls it a +“wearable robot.” (See Figure 10.) + +His goal, he said, is to help the paralyzed “walk by thinking.” He plans +to use wireless technology, “so there’s nothing sticking out of the head. +... We are going to record twenty to thirty thousand neurons, to +command a whole body robotic vest, so he can think and walk again and + + move and grab objects.”" +"move and grab objects.” + +Nicolelis realizes that a series of hurdles must be overcome before the +exoskeleton becomes a reality. First, a new generation of microchips +must be created that can be placed in the brain safely and reliably for +years at a time. Second, wireless sensors must be created so the +exoskeleton can roam freely. The signals from the brain would be +received wirelessly by a computer the size of a cell phone that would +probably be attached to your belt. Third, new advances must be made in +deciphering and interpreting signals from the brain via computers. For +the monkeys, a few hundred neurons were necessary to control the +mechanical arms. For a human, you need, at minimum, several thousand +neurons to control an arm or leg. And fourth, a power supply must be +found that is portable and powerful enough to energize the entire +exoskeleton. + +Figure 10. This is the exoskeleton that Dr. Nicolelis hopes will be controlled by the mind of a totally +paralyzed person." +"(illustration credit 4.1) + +Nicolelis’s goal is a lofty one: to have a working exoskeleton suit ready +for the 2014 World Cup in Brazil, where a quadriplegic Brazilian will +deliver the opening kick. He told me proudly, “This is our Brazilian +moon shot.” + +AVATARS AND SURROGATES + +In the movie Surrogates, Bruce Willis plays an FBI agent who is +investigating mysterious murders. Scientists have created exoskeletons so +perfect that they exceed human capabilities. These mechanical creatures +are super strong, with perfect bodies. In fact, they are so perfect that +humanity has become dependent on them. People live their entire life in +pods, mentally controlling their handsome, beautiful surrogate with" +"wireless technology. Everywhere you go, you see busy “people” at work, +except they are all perfectly shaped surrogates. Their aging masters are +conveniently hidden from view. The plot takes a sharp twist, however, +when Bruce Willis discovers that the person behind these murders might +be linked to the same scientist who invented these surrogates in the first +place. That forces him to wonder whether the surrogates are a blessing +or a curse." +"And in the blockbuster movie Avatar, in the year 2154 Earth has +depleted most of its minerals, so a mining company has journeyed to a +distant moon called Pandora in the Alpha Centauri star system in search +of a rare metal, unobtanium. There are native people who inhabit this +distant moon, called the Na’vi, who live in harmony with their lush +environment. In order to communicate with the native people, specially +trained workers are placed in pods, where they learn to mentally control +the body of a genetically engineered native. Although the atmosphere is +poisonous and the environment differs radically from Earth’s, avatars +have no difficulty living in this alien world. This uneasy relationship, +however, soon collapses when the mining company finds a rich deposit +of unobtainium underneath the Na’vi’s sacred ceremonial tree. Inevitably +a conflict arises between the mining company, which wants to destroy +the sacred tree and strip-mine the land for its rare metal, and the" +"the sacred tree and strip-mine the land for its rare metal, and the +natives, who worship it. It looks like a lost cause for the natives until one +of the specially trained workers switches sides and leads the Na’vi to +victory." +"Avatars and surrogates are the stuff of science fiction today, but one +day they may become an essential tool for science. The human body is +frail, perhaps too delicate for the rigors of many dangerous missions, +including space travel. Although science fiction is filled with the heroic +exploits of brave astronauts traveling to the farthest reaches of our +galaxy, the reality is much different. Radiation in deep space is so +intense that our astronauts will have to be shielded or else face +premature aging, radiation sickness, and even cancer. Solar flares shot +from the sun can bathe a spacecraft in lethal radiation. A simple +transatlantic flight from the United States to Europe exposes you to a +millirem of radiation per hour, or roughly the same as a dental X-ray. +But in outer space, the radiation could be many times more intense, +especially in the presence of cosmic rays and solar bursts. (During" +"intense solar storms, NASA has actually warned astronauts in the space +station to move to sections where there is more shielding against +radiation.) + +In addition, there are many other dangers awaiting us in outer space, +such as micrometeorites, the effects of prolonged weightlessness, and the +problems of adjusting to different gravity fields. After just a few months +in weightlessness, the body loses a large fraction of its calcium and +minerals, leaving the astronauts incredibly weak, even if they exercise +every day. After a year in outer space, Russian astronauts had to crawl +out of their space capsules like worms. Furthermore, it is believed that +some of the effects of muscle and bone loss are permanent, so that +astronauts will feel the consequences of prolonged weightlessness for the +rest of their lives." +"The dangers of micrometeorites and intense radiation fields on the +moon are so great that many scientists have proposed using a gigantic +underground cave as a permanent lunar space station to protect our +astronauts. These caves form naturally as lava tubes near extinct +volcanoes. But the safest way of building a moon base is to have our +astronauts sit in the comfort of their living rooms. This way they would +be shielded from all the hazards found on the moon, yet through +surrogates they would be able to perform the same tasks. This could +vastly reduce the cost of manned space travel, since providing life +support for human astronauts is very expensive. + +Perhaps when the first interplanetary ship reaches a distant planet, +and an astronaut’s surrogate sets foot on this alien terrain, he or she +might start with “One small step for the mind ...”" +"One possible problem with this approach is that it takes time for +messages to go to the moon and beyond. In a little over a second, a radio +message can travel from Earth to the moon, so surrogates on the moon +could be easily controlled by astronauts on Earth. More difficult would +be communicating with surrogates on Mars, since it can take twenty +minutes or more for radio signals to reach the Red Planet. + +But surrogates have practical implications closer to home. In Japan, +the Fukushima reactor accident in 2011 caused billions of dollars in +damages. Because workers can’t enter areas with lethal levels of +radiation for more than a few minutes, the final cleanup may take up to +forty years. Unfortunately, robots are not sufficiently advanced to go" +"into these blistering radiation fields and make needed repairs. In fact, +the only robots used at Fukushima are quite primitive, basically simple +cameras placed on top of a computer sitting on wheels. A full-blown +automaton that can think for itself (or be controlled by a remote +operator) and make repairs in high-radiation fields is many decades +away." +"The lack of industrial robots caused an acute problem for the Soviets +as well during the 1986 Chernobyl accident in the Ukraine. Workers sent +directly to the accident site to put out the flames died horrible deaths +due to lethal exposure to radiation. Eventually Mikhail Gorbachev +ordered the air force to “sand bag” the reactor, dropping five thousand +tons of borated sand and cement by helicopter. Radiation levels were so +high that 250,000 workers were recruited to finally contain the accident. +Each worker could spend only a few minutes inside the reactor building +doing repairs. Many received the maximum lifetime allowed dose of +radiation. Each one got a medal. This massive project was the largest +civil engineering feat ever undertaken. It could not have been done by +today’s robots." +"The Honda Corporation has, in fact, built a robot that may eventually +go into deadly radioactive environments, but it is not ready yet. Honda’s +scientists have placed an EEG sensor on the head of a worker, which is +connected to a computer that analyzes his brain waves. The computer is +then connected to a radio that sends messages to the robot, called +ASIMO (Advanced Step in Innovative Mobility). Hence, by altering his +own brain waves, a worker can control ASIMO by pure thought. + +Unfortunately, this robot is incapable of making repairs at Fukushima +right now, since it can execute only four basic motions (all of which +involve moving its head and shoulders) while hundreds of motions are +required to make repairs at a shattered nuclear power plant. This system +is not developed enough to handle simple tasks such as turning a +screwdriver or swinging a hammer." +"Other groups have also explored the possibility of mentally controlled +robots. At the University of Washington, Dr. Rajesh Rao has created a +similar robot that is controlled by a person wearing an EEG helmet. This +shiny humanoid robot is two feet tall and is called Morpheus (after a +character in the movie The Matrix, as well as the Greek god of dreams). +A student puts on the EEG helmet and then makes certain gestures, such" +"as moving a hand, which creates an EEG signal that is recorded by a +computer. Eventually the computer has a library of such EEG signals, +each one corresponding to a specific motion of a limb. Then the robot is +programmed to move its hand whenever that EEG signal is sent to it. In +this way, if you think about moving your hand, the robot Morpheus +moves its hand as well. When you put on the EEG helmet for the first +time, it takes about ten minutes for the computer to calibrate to your +brain signals. Eventually you get the hang of making gestures with your +mind that control the robot. For example, you can have it walk toward +you, pick up a block from a table, walk six feet to another table, and +then place the block there." +"Research is also progressing rapidly in Europe. In 2012, scientists in +Switzerland at the Ecole Poly technique Federate de Lausanne unveiled +their latest achievement, a robot controlled telepathically by EEG sensors +whose controller is located sixty miles away. The robot itself looks like +the Roomba robotic vacuum cleaner now found in many living rooms. +But it is actually a highly sophisticated robot equipped with a camera +that can navigate its way through a crowded office. A paralyzed patient +can, for example, look at a computer screen, which is connected to a +video camera on the robot many miles away, and see through the eyes of +the robot. Then, by thinking, the patient is able to control the motion of +the robot as it moves past obstacles." +"In the future, one can imagine the most dangerous jobs being done by +robots controlled by humans in this fashion. Dr. Nicolelis says, “We will +likely be able to operate remotely controlled envoys and ambassadors, +robots and airships of many shapes and sizes, sent on our behalf to +explore other planets and stars in distant corners of the universe.” + +For example, in 2010 the world looked on in horror as 5 million +barrels of crude oil spilled unabated into the Gulf of Mexico. The +Deepwater Horizon spill was one of the largest oil disasters in history, +yet engineers were largely helpless for three months. Robotic subs, +which are controlled remotely, floundered for weeks trying to cap the +well because they lacked the dexterity and versatility necessary for this +underwater mission. If surrogate subs, which are much more sensitive in +manipulating tools, had been available, they might have capped the well +in the first few days of the spill, preventing billions in property damage +and lawsuits." +"Another possibility is that surrogate submarines might one day enter +the human body and perform delicate surgery from the inside. This idea +was explored in the movie Fantastic Voyage, starring Raquel Welch, in +which a submarine was shrunk down to the size of a blood cell and then +injected into the bloodstream of someone who had a blood clot in his +brain. Shrinking atoms violates the laws of quantum physics, but one +day MEMS (micro-electrical-mechanical systems) the size of cells might +be able to enter a person’s bloodstream. MEMS are incredibly small +machines that can easily fit on a pinpoint. MEMS employ the same +etching technology used in Silicon Valley, which can put hundreds of +millions of transistors on a wafer the size of your fingernail. An +elaborate machine with gears, levers, pulleys, and even motors can be +made smaller than the period at the end of this sentence. One day a +person may be able to put on a telepathy helmet and then command a" +"person may be able to put on a telepathy helmet and then command a +MEMS submarine using wireless technology to perform surgery inside a +patient." +"So MEMS technology may open up an entirely new field of medicine, +based on microscopic machines entering the body. These MEMS +submarines might even guide nanoprobes as they enter the brain so that +they connect precisely to the neurons that are of interest. In this way, +nanoprobes might be able to receive and transmit signals from the +handful of neurons that are involved in specific behaviors. The hit-or- +miss approach of inserting electrodes into the brain will be eliminated. + +THE FUTURE + +In the short term, all these remarkable advances taking place in + + laboratories around the world may alleviate the suffering of those +afflicted by paralysis and other disabilities. Using the power of their +minds, they will be able to communicate with loved ones, control their +wheelchairs and beds, walk by mentally guiding mechanical limbs, +manipulate household appliances, and lead seminormal lives." +"But in the long term, these advances could have profound economic +and practical implications for the world. By mid-century, it could +become commonplace to interact with computers directly with the mind. +Since the computer business is a multitrillion-dollar industry that can + +create young billionaires and corporations almost overnight, advances in +the mind-computer interface will reverberate on Wall Street—and also in +your living room. + +All the devices we use to communicate with computers (the mouse, +keyboards, etc.) may eventually disappear. In the future, we may simply +give mental commands and our wishes will be silently carried out by +tiny chips hidden in the environment. While sitting in our offices, taking +a stroll in the park, doing window-shopping, or just relaxing, our minds +could be interacting with scores of hidden chips, allowing us to mentally +balance our finances, arrange for theater tickets, or make a reservation." +"Artists may also make good use of this technology. If they can +visualize their artwork in their minds, then the image can be displayed +via EEG sensors on a holographic screen in 3-D. Since the image in the +mind is not as precise as the original object, the artist could then make +improvements on the 3-D image and dream up the next iteration. After +several cycles, the artist could print out the final image on a 3-D printer. + +Similarly, engineers would be able to create scale models of bridges, +tunnels, and airports by simply using their imagination. They could also +rapidly make changes in their blueprints through thought alone. +Machine parts could fly off the computer screen and into a 3-D printer." +"Some critics, however, have claimed that these telekinetic powers +have one great limitation: the lack of energy. In the movies, super beings +have the power to move mountains using their thoughts. In the movie X- +Men: The Last Stand, the super villain Magneto had the ability to move +the Golden Gate Bridge simply by pointing his fingers, but the human +body can muster only about one-fifth of a horsepower on average, which +is much too little power to perform the feats we see in the comic books. +Therefore, all the herculean feats of telekinetic super beings appear to be +pure fantasy. + +There is one solution to this energy problem, however. You may be +able to connect your thoughts to a power source, which would then" +"magnify your power millions of times. In this way, you could +approximate the power of a god. In one episode of Star Trek, the crew +journeys to a distant planet and meets a godlike creature who claims to +be Apollo, the Greek god of the sun. He can perform feats of magic that +dazzle the crew. He even claims to have visited Earth eons ago, where +the earthlings worshipped him. But the crew, not believing in gods, + +suspect a fraud. Later they figure out that this “god” just mentally +controls a hidden power source, which then performs all the magic +tricks. When this power source is destroyed, he becomes a mere mortal." +"Similarly, in the future our minds may mentally control a power +source that will then give us superpowers. For example, a construction +worker might telepathically exploit a power source that energizes heavy +machinery. Then a single worker might be able to build complex +buildings and houses just by using the power of his mind. All the heavy +lifting would be done by the power source, and the construction worker +would resemble a conductor, able to orchestrate the motion of colossal +cranes and powerful bulldozers through thought alone. + +Science is beginning to catch up to science fiction in yet another way. +The Star Wars saga was supposed to take place in a time when +civilizations span the entire galaxy. The peace of the galaxy, in turn, is +maintained by the Jedi Knights, a highly trained cadre of warriors who +use the power of the “Force” to read minds and guide their lightsabers." +"However, one need not wait until we have colonized the entire galaxy +to begin contemplating the Force. As we’ve seen, some aspects of the +Force are possible today, such as being able to tap into the thoughts of +others using ECOG electrodes or EEG helmets. But the telekinetic powers +of the Jedi Knights will also become a possibility as we learn to harness +a power source with our minds. The Jedi Knights, for example, can +summon a light-saber simply by waving their hands, but we can already +accomplish the same feat by exploiting the power of magnetism (much +as the magnet in an MRI machine can hurl a hammer across a room). By +mentally activating the power source, you can grab lightsabers from +across the room with today’s technology. + +THE POWER OF A GOD" +"THE POWER OF A GOD + +Telekinesis is a power usually reserved for a deity or a superhero. In the +universe of superheros appearing in blockbuster Hollywood movies, +perhaps the most powerful character is Phoenix, a telekinetic woman +who can move any object at will. As a member of the X-Men, she can lift +heavy machinery, hold back floods, or raise jet airplanes via the power + + of her mind. (However, when she is finally consumed by the dark side of + +her power, she goes on a cosmic rampage, capable of incinerating entire +solar systems and destroying stars. Her power is so great and +uncontrollable that it leads to her eventual self-destruction.) + +But how far can science go in harnessing telekinetic powers?" +"But how far can science go in harnessing telekinetic powers? + +In the future, even with an external power source to magnify our +thoughts, it is unlikely that people with telekinetic powers will be able +to move basic objects like a pencil or mug of coffee on command. As we +mentioned, there are only four known forces that rule the universe, and +none of them can move objects unless there is an external power source. +(Magnetism comes close, but magnetism can move only magnetic +objects. Objects made of plastic, water, or wood can easily pass through +magnetic fields.) Simple levitation, a trick found in most magicians’ +shows, is beyond our scientific capability. + +So even with an external power supply, is it unlikely that a telekinetic +person would be able to move the objects around them at will. However, +there is a technology that may come close, and that involves the ability +to change one object into another." +"The technology is called “programmable matter,” and it has become a +subject of intense research for the Intel Corporation. The idea behind +programmable matter is to create objects made of tiny “catoms,” which +are microscopic computer chips. Each catom can be controlled +wirelessly; it can be programmed to change the electrical charge on its +surface so it can bind with other catoms in different ways. By +programming the electric charges one way, the catoms bind together to +form, say, a cell phone. Push a button to change their programming, and +the catoms rearrange themselves to re-form into another object, like a +laptop." +"I saw a demonstration of this technology at Carnegie Mellon +University in Pittsburgh, where scientists have been able to create a chip +the size of a pinpoint. To exam these catoms, I had to enter a “clean +room” wearing a special white uniform, plastic boots, and a cap to +prevent even the smallest dust particle from entering. Then, under a +microscope, I could see the intricate circuitry inside each catom, which +makes it possible to program it wirelessly to change the electrical charge +on its surface. In the same way we can program software today, in the +future it may be possible to program hardware. + +The next step is to determine if these catoms can combine to form" +"The next step is to determine if these catoms can combine to form + + useful objects, and to see if they can be changed or morphed into +another object at will. It may take until mid-century before we have +working prototypes of programmable matter. Because of the complexity +of programming billions of catoms, a special computer would have to be +created to orchestrate the charge on each catom. Perhaps by the end of +this century, it will be possible to mentally control this computer so that +we can change one object into another. We would not have to memorize +the charges and configuration within an object. We would just give the +mental command to the computer to change one object into another." +"Eventually we might have catalogs listing all the various objects that +are programmable, such as furniture, appliances, and electronics. Then +by telepathically communicating with the computer, it should be +possible to change one object into another. Redecorating your living +room, remodeling your kitchen, and buying Christmas presents could all +be done mentally. + +A MORALITY TALE + +Having every wish come true is something that only a divinity can +accomplish. However, there is also a downside to this celestial power. +All technologies can be used for good or for evil. Ultimately, science is a +double-edged sword. One side of the sword can cut against poverty, +disease, and ignorance. But the other side can cut against people, in +several ways." +"These technologies could conceivably make wars even more vicious. +Perhaps one day, all hand-to-hand combat will be between two +surrogates, armed with a battery of high-tech weapons. The actual +warriors, sitting safely thousands of miles away, would unleash a +barrage of the latest high-tech weaponry with little regard for the +collateral damage they are inflicting on civilians. Although wars fought +with surrogates may preserve the lives of the soldiers themselves, they +might also cause horrendous civilian and property damage. + +The bigger problem is that this power may also be too great for any +common mortal to control. In the novel Carrie, Stephen King explored +the world of a young girl who was constantly taunted by her peers. She +was ostracized by the in-crowd and her life became a never-ending series + +of insults and humiliations. However, her tormentors did not know one +thing about her: she was telekinetic. + +After enduring the taunts and having blood splashed all over her dress" +"After enduring the taunts and having blood splashed all over her dress + + at the prom, she finally cracks. She summons all her telekinetic power to +trap her classmates and then annihilate them one by one. In a final +gesture, she decides to burn the entire school down. But her telekinetic +power was too great to control. She ultimately perishes in the fire that +she started. + +Not only can the awesome power of telekinesis backfire, but there is +another problem as well. Even if you have taken all the precautions to +understand and harness this power, it could still destroy you if, +ironically enough, it is too obedient to your thoughts and commands. +Then the very thoughts you conceive may spell your doom." +"The movie Forbidden Planet (1956) is based on a play by William +Shakespeare, The Tempest, which begins with a sorcerer and his daughter +stranded on a deserted island. But in Forbidden Planet, a professor and his +daughter are stranded on a distant planet that was once the home of the +Krell, a civilization millions of years more advanced than ours. Their +greatest achievement was to create a device that gave them the ultimate +power of telekinesis, the power to control matter in all its forms by the +mind. Anything they desired suddenly materialized before them. This +was the power to reshape reality itself to their whims. + +Yet on the eve of their greatest triumph, as they were turning on this +device the Krell disappeared without a trace. What could have possibly +destroyed this most advanced civilization?" +"When a crew of earthmen land on the planet to rescue the man and +his daughter, they find that there is a hideous monster haunting the +planet, slaughtering crew members at will. Finally, one crew member +discovers the secret behind both the Krell and the monster. Before he +dies, he gasps, “Monsters from the id.” + +Then the shocking truth suddenly dawns on the professor. The very +night that the Krell turned on their telekinesis machine, they fell asleep. +All the repressed desires from their ids then suddenly materialized. +Buried in the subconscious of these highly developed creatures were the +long-suppressed animal urges and desires of their ancient past. Every +fantasy, every dream of revenge suddenly came true, so this great +civilization destroyed itself overnight. They had conquered many worlds, + +but there was one thing they could not control: their own subconscious +minds." +"but there was one thing they could not control: their own subconscious +minds. + +That is a lesson for anyone who desires to unleash the power of the +mind. Within the mind, you find the noblest achievements and thoughts +of humanity. But you will also find monsters from the id. + + CHANGING WHO WE ARE: OUR MEMORIES AND INTELLIGENCE + +So far, we have discussed the power of science to extend our mental +abilities via telepathy and telekinesis. We basically remain the same; +these developments do nothing to change the essence of who we are. +However, there is an entirely new frontier opening up that alters the +very nature of what it means to be human. Using the very latest in +genetics, electromagnetics, and drug therapy, it may become possible in +the near future to alter our memories and even enhance our intelligence. +The idea of downloading a memory, learning complex skills overnight, +and becoming super intelligent is slowly leaving the realm of science +fiction." +"Without our memories, we are lost, cast adrift in an aimless sea of +pointless stimuli, unable to understand the past or ourselves. So what +happens if one day we can input artificial memories into our brains? +What happens when we can become a master of any discipline simply by +downloading the file into our memory? And what happens if we cannot +tell the difference between real and fake memories? Then who are we? + +Scientists are moving past being passive observers of nature to actively +shaping and molding nature. This means that we might be able to +manipulate memories, thoughts, intelligence, and consciousness. Instead +of simply witnessing the intricate mechanics of the mind, in the future it +will be possible to orchestrate them. + +So let us now answer this question: Can we download memories? + +If our brains were simple enough to be understood, we +wouldn’t be smart enough to understand them. + +—ANONYMOUS + +5 MEMORIES AND THOUGHTS MADE TO ORDER" +"—ANONYMOUS + +5 MEMORIES AND THOUGHTS MADE TO ORDER + +Neo is The One. Only he can lead a defeated humanity to victory +against the Machines. Only Neo can destroy the Matrix, which has +implanted false memories into our brains as a means to control us. + +In a now-classic scene from the film The Matrix, the evil Sentinels, +who guard the Matrix, have finally cornered Neo. It looks like +humanity’s last hope is about to be terminated. But previously Neo had + + had an electrode jacked into the back of his neck that could instantly +download martial-arts skills into his brain. In seconds, he becomes a +karate master able to take down the Sentinels with breathtaking aerial +kicks and well-placed strikes. + +In The Matrix, learning the amazing skills of a black-belt karate master +is no harder than slipping an electrode into your brain and pushing the +“download” button. Perhaps one day we, too, may be able to download +memories, which will vastly increase our abilities." +"But what happens when the memories downloaded into your brain are +false? In the movie Total Recall, Arnold Schwarzenegger has fake +memories placed into his brain, so that the distinction between reality +and fiction becomes totally blurred. He valiantly fights off the bad guys +on Mars until the end of the movie, when he suddenly realizes that he +himself is their leader. He is shocked to find that his memories of being a +normal, law-abiding citizen are totally manufactured. + +Hollywood is fond of movies that explore the fascinating but fictional +world of artificial memories. All this is impossible, of course, with +today’s technology, but one can envision a day, a few decades from now, +when artificial memories may indeed be inserted into the brain. + +HOW WE REMEMBER + +Like Phineas Gage’s, the strange case of Henry Gustav Molaison, known +in the scientific literature as simply HM, created a sensation in the field" +"of neurology that led to many fundamental breakthroughs in +understanding the importance of the hippocampus in formulating +memories." +"At the age of nine, HM suffered head injuries in an accident that +caused debilitating convulsions. In 1953, when he was twenty-five years +old, he underwent an operation that successfully relieved his symptoms. +But another problem surfaced because surgeons mistakenly cut out part +of his hippocampus. At first, HM appeared normal, but it soon became +apparent that something was terribly wrong; he could not retain new +memories. Instead, he constantly lived in the present, greeting the same +people several times a day with the same expressions, as if he were +seeing them for the first time. Everything that went into his memory +lasted only a few minutes before it disappeared. Like Bill Murray in the +movie Groundhog Day, HM was doomed to relive the same day, over and +over, for the rest of his life. But unlike Bill Murray’s character, he was +unable to recall the previous iterations. His long-term memory, however," +"was relatively intact and could remember his life before the surgery. But +without a functioning hippocampus, HM was unable to record new +experiences. For example, he would be horrified when looking in a +mirror, since he saw the face of an old man but thought he was still +twenty-five. But mercifully, the memory of being horrified would also +soon disappear into the fog. In some sense, HM was like an animal with +Level II consciousness, unable to recall the immediate past or simulate +the future. Without a functioning hippocampus, he regressed from Level +III down to Level II consciousness. + +Today, further advances in neuroscience have given us the clearest +picture yet of how memories are formed, stored, and then recalled. “It +has all come together just in the past few years, due to two technical +developments—computers and modern brain scanning,” says Dr. +Stephen Kosslyn, a neuroscientist at Harvard." +"As we know, sensory information (e.g., vision, touch, taste) must first +pass through the brain stem and onto the thalamus, which acts like a +relay station, directing the signals to the various sensory lobes of the +brain, where they are evaluated. The processed information reaches the +prefrontal cortex, where it enters our consciousness and forms what we +consider our short-term memory, which can range from several seconds +to minutes. (See Figure 11.)" +"To store these memories for a longer duration, the information must +then run through the hippocampus, where memories are broken down +into different categories. Rather than storing all memories in one area of +the brain like a tape recorder or hard drive, the hippocampus redirects +the fragments to various cortices. (Storing memories in this way is +actually more efficient than storing them sequentially. If human +memories were stored sequentially, like on computer tape, a vast +amount of memory storage would br required. In fact, in the future, even +digital storage systems may adopt this trick from the living brain, rather +than storing whole memories sequentially.) For instance, emotional +memories are stored in the amygdala, but words are recorded in the +temporal lobe. Meanwhile, colors and other visual information are +collected in the occipital lobe, and the sense of touch and movement +reside in the parietal lobe. So far, scientists have identified more than" +"reside in the parietal lobe. So far, scientists have identified more than +twenty categories of memories that are stored in different parts of the +brain, including fruits and vegetables, plants, animals, body parts, +colors, numbers, letters, nouns, verbs, proper names, faces, facial +expressions, and various emotions and sounds." +"Figure 11. This shows the path taken to create memories. Impulses from the senses pass through the +brain stem, to the + + thalamus, out to the various cortices, and then to the prefrontal cortex. They then pass to the +hippocampus to form long¬ +term memories, (illustration credit 5.1) + +A single memory—for instance, a walk in the park—involves +information that is broken down and stored in various regions of the +brain, but reliving just one aspect of the memory (e.g., the smell of +freshly cut grass) can suddenly send the brain racing to pull the +fragments together to form a cohesive recollection. The ultimate goal of +memory research is, then, to figure out how these scattered fragments +are somehow reassembled when we recall an experience. This is called +the “binding problem,” and a solution could potentially explain many +puzzling aspects of memory. For instance, Dr. Antonio Damasio has +analyzed stroke patients who are incapable of identifying a single" +"category, even though they are able to recall everything else. This is +because the stroke has affected just one particular area of the brain, +where that certain category was stored. + +The binding problem is further complicated because all our memories +and experiences are highly personal. Memories might be customized for +the individual, so that the categories of memories for one person may +not correlate with the categories of memories for another. Wine tasters, +for example, may have many categories for labeling subtle variations in +taste, while physicists may have other categories for certain equations. +Categories, after all, are by-products of experience, and different people +may therefore have different categories." +"One novel solution to the binding problem uses the fact that there are +electromagnetic vibrations oscillating across the entire brain at roughly +forty cycles per second, which can be picked up by EEG scans. One +fragment of memory might vibrate at a very precise frequency and +stimulate another fragment of memory stored in a distant part of the +brain. Previously it was thought that memories might be stored +physically close to one another, but this new theory says that memories +are not linked spatially but rather temporally, by vibrating in unison. If +this theory holds up, it means that there are electromagnetic vibrations +constantly flowing through the entire brain, linking up different regions +and thereby re-creating entire memories. Hence the constant flow of +information between the hippocampus, the prefrontal cortex, the +thalamus, and the different cortices might not be entirely neural after +all. Some of this flow may be in the form of resonance across different +brain structures." +"RECORDING A MEMORY + + Sadly, HM died in 2008 at the age of eighty-two, before he could take +advantage of some sensational results achieved by science: the ability to +create an artificial hippocampus and then insert memories into the brain. +This is something straight out of science fiction, but scientists at Wake +Forest University and the University of Southern California made history +in 2011 when they were able to record a memory made by mice and +store it digitally in a computer. This was a proof-of-principle experiment, + +in which they showed that the dream of downloading memories into the +brain might one day become reality." +"At first, the very idea of downloading memories into the brain seems +like an impossible dream, because, as we have seen, memories are +created by processing a variety of sensory experiences, which are then +stored in multiple places in the neocortex and limbic system. But as we +know from HM, there is one place through which all memories flow and +are converted into long-term memories: the hippocampus. Team leader +Dr. Theodore Berger of USC says, “If you can’t do it with the +hippocampus, you can’t do it anywhere.”" +"The scientists at Wake Forest and USC first started with the +observation, garnered from brain scans, that there are at least two sets of +neurons in a mouse’s hippocampus, called CA1 and CA3, which +communicate with each other as a new task is learned. After training +mice to press two bars, one after the other, in order to get water, the +scientists reviewed the findings and attempted to decode these messages, +which proved frustrating at first since the signals between these two sets +of neurons didn’t appear to follow a pattern. But by monitoring the +signals millions of times, they were eventually able to determine which +electrical input created which output. With the use of probes in the +mice’s hippocampi, the scientists were able to record the signals between +CA1 and CA3 when the mice learned to press the two bars in sequence." +"Then the scientists injected the mice with a special chemical, making +them forget the task. Finally they played back the memory into the same +mouse’s brain. Remarkably, the memory of the task returned, and the +mice could successfully reproduce the original task. Essentially, they had +created an artificial hippocampus with the ability to duplicate digital +memory. “Turn the switch on, the animal has the memory; turn it off +and they don’t,” says Dr. Berger. “It’s a very important step because it’s +the first time we have put all the pieces together.” + +As Joel Davis of the Office of the Chief of Naval Operations, which +sponsored this work, said, “Using implantables to enhance competency is +down the road. It’s only a matter of time.”" +"Not surprisingly, with so much at stake, this area of research is +moving very rapidly. In 2013, yet another breakthrough was made, this +time at MIT, by scientists who were able to implant not just ordinary +memories into a mouse, but false ones as well. This means that, one day, + +memories of events that never took place may be implanted into the +brain, which would have a profound impact on fields like education and +entertainment. + +The MIT scientists used a technique called optogenetics (which we will +discuss more in Chapter 8), which allows you to shine a light on specific +neurons to activate them. Using this powerful method, scientists can +identify the specific neurons responsible for certain memories." +"Let’s say that a mouse enters a room and is given a shock. The neurons +responsible for the memory of that painful event can actually be isolated +and recorded by analyzing the hippocampus. Then the mouse is placed +in an entirely different room that is totally harmless. By turning on a +light on an optical fiber, one can use optogenetics to activate the +memory of the shock, and the mouse exhibits a fear response, although +the second room is totally safe. + +In this way, the MIT scientists were able not only to implant ordinary +memories, but also memories of events that never took place. One day, +this technique may give educators the ability to implant memories of +new skills to retrain workers, or give Hollywood an entirely new form of +entertainment. + +AN ARTIFICIAL HIPPOCAMPUS" +"AN ARTIFICIAL HIPPOCAMPUS + +At present, the artificial hippocampus is primitive, able to record only a +single memory at a time. But these scientists plan to increase the +complexity of their artificial hippocampus so that it can store a variety +of memories and record them for different animals, eventually working +up to monkeys. They also plan to make this technology wireless by +replacing the wires with tiny radios so that memories can be +downloaded remotely without the need for clumsy electrodes implanted +into the brain. + +Because the hippocampus is involved with memory processing in +humans, scientists see a vast potential application in treating strokes, +dementia, Alzheimer’s, and a host of other problems that occur when +there is damage or deterioration in this region of the brain. + + Many hurdles have to be negotiated, of course. Despite all we have +learned about the hippocampus since HM, it still remains something of a" +"black box whose inner workings are largely unknown. As a result, it is +not possible to construct a memory from scratch, but once a task has +been performed and the memory processed, it is possible to record it and +play it back. + +FUTURE DIRECTIONS + +Working with the hippocampus of primates and even humans will be +more difficult, since their hippocampi are much larger and more +complex. The first step is to create a detailed neural map of the +hippocampus. This means placing electrodes at different parts of the +hippocampus to record the signals that are constantly being exchanged +between different regions. This will establish the flow of information +that constantly moves across the hippocampus. The hippocampus has +four basic divisions, CA1 to CA4, and hence scientists will record the +signals that are exchanged between them." +"The second step involves the subject performing certain tasks, after +which scientists will record the impulses that flow across the various +regions of the hippocampus, thereby recording the memory. For +example, the memory of learning a certain task, such as jumping +through a hoop, will create electrical activity in the hippocampus that +can be recorded and carefully analyzed. Then a dictionary can be +created matching the memory with the flow of information across the +hippocampus. + +Finally, step three involves making a recording of this memory and +feeding the electrical signal into the hippocampus of another subject via +electrodes, to see if that memory can been uploaded. In this fashion, the +subject may learn to jump through a hoop although it has never done so +before. If successful, scientists would gradually create a library +containing recordings of certain memories." +"It may take decades to work all the way up to human memories, but +one can envision how it might work. In the future, people may be hired +to create certain memories, like a luxury vacation or a fictitious battle. +Nanoelectrodes will be placed at various places in their brain to record +the memory. These electrodes must be extremely small so that they do +not interfere with the formation of the memory. + +The information from these electrodes will then be sent wirelessly to a + + computer and then recorded. Later a subject who wants to experience +these memories will have similar electrodes placed in his hippocampus, +and the memory will be inserted into the brain." +"(There are complications to this idea, of course. If we try to insert the +memory of physical activity, such as a martial art, we have the problem +of “muscle memory.” For example, when walking, we do not consciously +think about putting one leg in front of the other. Walking has become +second nature to us because we do it so often, and from an early age. +This means that the signals controlling our legs no longer originate +entirely in the hippocampus, but also in the motor cortex, the +cerebellum, and the basal ganglia. In the future, if we wish to insert +memories involving sports, scientists may have to decipher the way in +which memories are partially stored in other areas of the brain as well.) + +VISION AND HUMAN MEMORIES" +"VISION AND HUMAN MEMORIES + +The formation of memories is quite complex, but the approach we have +been discussing takes a shortcut by eavesdropping on the signals moving +through the hippocampus, where the sensory impulses have already +been processed. In The Matrix, however, an electrode is placed in the +back of the head to upload memories directly into the brain. This +assumes that one can decode the raw, unprocessed impulses coming in +from the eyes, ears, skin, etc., that are moving up the spinal cord and +brain stem and into the thalamus. This is much more elaborate and +difficult than analyzing the processed messages circulating in the +hippocampus." +"To give you a sense of the sheer volume of unprocessed information +that comes up the spinal cord into the thalamus, let’s consider just one +aspect: vision, since many of our memories are encoded this way. There +are roughly 130 million cells in the eye’s retina, called cones and rods; +they process and record 100 million bits of information from the +landscape at any time. + +This vast amount of data is then collected and sent down the optic +nerve, which transports 9 million bits of information per second, and on +to the thalamus. From there, the information reaches the occipital lobe, + +at the very back of the brain. This visual cortex, in turn, begins the +arduous process of analyzing this mountain of data. The visual cortex +consists of several patches at the back of the brain, each of which is +designed for a specific task. They are labeled VI to V8. + +Remarkably, the area called VI is like a screen; it actually creates a" +"Remarkably, the area called VI is like a screen; it actually creates a + + pattern on the back of your brain very similar in shape and form to the +original image. This image bears a striking resemblance to the original, +except that the very center of your eye, the fovea, occupies a much +larger area in VI (since the fovea has the highest concentration of +neurons). The image cast on VI is therefore not a perfect replica of the +landscape but is distorted, with the central region of the image taking up +most of the space. + +Besides VI, other areas of the occipital lobe process different aspects +of the image, including: + +• Stereo vision. These neurons compare the images coming in from +each eye. This is done in area V2. + +• Distance. These neurons calculate the distance to an object, using +shadows and other information from both eyes. This is done in area +V3. + +• Colors are processed in area V4." +"• Colors are processed in area V4. + +• Motion. Different circuits can pick out different classes of motion, +including straight-line, spiral, and expanding motion. This is done in +area V5. + +More than thirty different neural circuits involved with vision have +been identified, but there are probably many more. + +From the occipital lobe, the information is sent to the prefrontal +cortex, where you finally “see” the image and form your short-term +memory. The information is then sent to the hippocampus, which +processes it and stores it for up to twenty-four hours. The memory is +then chopped up and scattered among the various cortices. + +The point here is that vision, which we think happens effortlessly, +requires billions of neurons firing in sequence, transmitting millions of +bits of information per second. And remember that we have signals from +five sense organs, plus emotions associated with each image. All this" +"information is processed by the hippocampus to create a simple memory +of an image. At present, no machine can match the sophistication of this +process, so replicating it presents an enormous challenge for scientists +who want to create an artificial hippocampus for the human brain. + +REMEMBERING THE FUTURE + + If encoding the memory of just one of the senses is such a complex +process, then how did we evolve the ability to store such vast amounts of +information in our long-term memory? Instinct, for the most part, guides +the behavior of animals, which do not appear to have much of a long¬ +term memory. But as neurobiologist Dr. James McGaugh of the +University of California at Irvine says, “The purpose of memory is to +predict the future,” which raises an interesting possibility. Perhaps long¬ +term memory evolved because it was useful for simulating the future. In +other words, the fact that we can remember back into the distant past is +due to the demands and advantages of simulating the future." +"Indeed, brain scans done by scientists at Washington University in St. +Louis indicate that areas used to recall memories are the same as those +involved in simulating the future. In particular, the link between the +dorsolateral prefrontal cortex and the hippocampus lights up when a +person is engaged in planning for the future and remembering the past. +In some sense, the brain is trying to “recall the future,” drawing upon +memories of the past in order to determine how something will evolve +into the future. This may also explain the curious fact that people who +suffer from amnesia—such as HM—are often unable to visualize what +they will be doing in the future or even the very next day." +"“You might look at it as mental time travel—the ability to take +thoughts about ourselves and project them either into the past or into +the future,” says Dr. Kathleen McDermott of Washington University. She +also notes that their study proves a “tentative answer to a longstanding +question regarding the evolutionary usefulness of memory. It may just be +that the reason we can recollect the past in vivid detail is that this set of +processes is important for being able to envision ourselves in future +scenarios. This ability to envision the future has clear and compelling +adaptive significance.” For an animal, the past is largely a waste of + +precious resources, since it gives them little evolutionary advantage. But +simulating the future, given the lessons of the past, is an essential reason +why humans became intelligent. + +AN ARTIFICIAL CORTEX" +"AN ARTIFICIAL CORTEX + +In 2012 the same scientists from Wake Forest Baptist Medical Center and +the University of Southern California who created an artificial +hippocampus in mice announced an even more far-reaching experiment. +Instead of recording a memory in the mouse hippocampus, they +duplicated the much more sophisticated thinking process of the cortex of +a primate." +"They took five rhesus monkeys and inserted tiny electrodes into two +layers of their cortex, called the L2/3 and L5 layers. They then recorded +neural signals that went between these two layers as the monkeys +learned a task. (This task involved the monkeys seeing a set of pictures, +and then being rewarded if they could pick out these same pictures from +a much larger set.) With practice, the monkeys could perform the task +with 75 percent accuracy. But if the scientists fed the signal back into +the cortex as the monkey was performing the test, its performance +increased by 10 percent. When certain chemicals were given to the +monkey, its performance dropped by 20 percent. But if the recording +was fed back into the cortex, its performance exceeded its normal level. +Although this was a small sample size and there was only a modest +improvement in performance, the study still suggests that the scientists’ +recording accurately captured the decision-making process of the cortex." +"Because this study was done on primates rather than mice and +involved the cortex and not the hippocampus, it could have vast +implications when human trials begin. Dr. Sam A. Deadwyler of Wake +Forest says, “The whole idea is that the device would generate an output +pattern that bypasses the damaged area, proving an alternative +connection” in the brain. This experiment has a possible application for +patients whose neocortex has been damaged. Like a crutch, this device +would perform the thinking operation of the damaged area. + +AN ARTIFICIAL CEREBELLUM + +It should also be pointed out that the artificial hippocampus and +neocortex are but the first steps. Eventually, other parts of the brain will +have artificial counterparts. For example, scientists at Tel Aviv +University in Israel have already created an artificial cerebellum for a +rat. The cerebellum is an essential part of the reptilian brain that +controls our balance and other basic bodily functions." +"Usually when a puff of air is directed at a rat’s face, it blinks. If a +sound is made at the same time, the rat can be conditioned to blink just +by hearing the sound. The goal of the Israeli scientists was to create an +artificial cerebellum that could duplicate this feat. + +First the scientists recorded the signals entering the brain stem when +the puff of air hit the rat’s face and the sound was heard. Then the signal +was processed and sent back to the brain stem at another location. As +expected, the rats blinked upon receiving the signal. Not only is this the +first time that an artificial cerebellum functioned correctly, it is the first +time that messages were received from one part of the brain, processed, +and then uploaded into a different part of the brain." +"Commenting on this work, Francesco Sepulveda of the University of +Essex says, “This demonstrates how far we have come towards creating +circuitry that could one day replace damaged brain areas and even +enhance the power of the healthy brain.” + +He also sees great potential for artificial brains in the future, adding, +“It will likely take us several decades to get there, but my bet is that +specific, well-organized brain parts such as the hippocampus or the +visual cortex will have synthetic correlates before the end of the +century.” + +Although progress in creating artificial replacements for the brain is +moving remarkably fast given the complexity of the process, it is a race +against time when one considers the greatest threat facing our public +health system, the declining mental abilities of people with Alzheimer’s. + +ALZHEIMER’S—DESTROYER OF MEMORY" +"ALZHEIMER’S—DESTROYER OF MEMORY + +Alzheimer’s disease, some people claim, might be the disease of the +century. There are 5.3 million Americans who currently have +Alzheimer’s, and the number is expected to quadruple by 2050. Five + +percent of people from age sixty-five to seventy-four have Alzheimer’s, +but more than 50 percent of those over eighty-five have it, even if they +have no obvious risk factors. (Back in 1900, life expectancy in the +United States was forty-nine, so Alzheimer’s was not a significant +problem. But now, people over eighty are one of the fastest-growing +demographic groups in the country.)" +"In the early stages of Alzheimer’s, the hippocampus, the part of the +brain through which memories are processed, begins to deteriorate. +Indeed, brain scans clearly show that the hippocampus shrinks in +Alzheimer’s patients, but the wiring linking the prefrontal cortex to the +hippocampus also thins, leaving the brain unable to properly process +short-term memories. Long-term memories already stored throughout +the cortices of the brain remain relatively intact, at least at first. This +creates a situation where you may not remember what you just did a few +minutes ago but can clearly recall events that took place decades ago. + +Eventually, the disease progresses to the point where even basic long¬ +term memories are destroyed. The person is unable to recognize their +children or spouse and to remember who they are, and can even fall into +a comalike vegetative state. + +Sadly, the basic mechanisms for Alzheimer’s have only recently begun" +"Sadly, the basic mechanisms for Alzheimer’s have only recently begun + + to be understood. One major breakthrough came in 2012, when it was +revealed that Alzheimer’s begins with the formation of tau amyloid +proteins, which in turn accelerates the formation of beta amyloid, a +gummy, gluelike substance that clogs up the brain. (Before, it was not +clear if Alzheimer’s was caused by these plaques or whether perhaps +these plaques were by-products of a more fundamental disorder.)" +"What makes these amyloid plaques so difficult to target with drugs is +that they are most likely made of “prions,” which are misshapen protein +molecules. They are not bacteria or viruses, but nevertheless they can +reproduce. When viewed atomically, a protein molecule resembles a +jungle of ribbons of atoms tied together. This tangle of atoms must fold +onto itself correctly for the protein to assume the proper shape and +function. But prions are misshapen proteins that have folded incorrectly. +Worse, when they bump into healthy proteins, they cause them to fold +incorrectly as well. Hence one prion can cause a cascade of misshapen +proteins, creating a chain reaction that contaminates billions more. + +At present, there is no known way to stop the inexorable progression" +"At present, there is no known way to stop the inexorable progression + +of Alzheimer’s. Now that the basic mechanics behind Alzheimer’s are +being unraveled, however, one promising method is to create antibodies +or a vaccine that might specifically target these misshapen protein +molecules. Another way might be to create an artificial hippocampus for +these individuals so that their short-term memory can be restored. + +Yet another approach is to see if we can directly increase the brain’s +ability to create memories using genetics. Perhaps there are genes that +can improve our memory. The future of memory research may lie in the +“smart mouse.” + +THE SMART MOUSE" +"THE SMART MOUSE + +In 1999, Dr. Joseph Tsien and colleagues at Princeton, MIT, and +Washington University found that adding a single extra gene +dramatically boosted a mouse’s memory and ability. These “smart mice” +could navigate mazes faster, remember events better, and outperform +other mice in a wide variety of tests. They were dubbed “Doogie mice,” +after the precocious character on the TV show Doogie Howser, M.D. + +Dr. Tsien began by analyzing the gene NR2B, which acts like a switch +controlling the brain’s ability to associate one event with another. +(Scientists know this because when the gene is silenced or rendered +inactive, mice lose this ability.) All learning depends on NR2B, because +it controls the communication between memory cells of the" +"hippocampus. First Dr. Tsien created a strain of mice that lacked NR2B, +and they showed impaired memory and learning disabilities. Then he +created a strain of mice that had more copies of NR2B than normal, and +found that the new mice had superior mental capabilities. Placed in a +shallow pan of water and forced to swim, normal mice would swim +randomly about. They had forgotten from just a few days before that +there was a hidden underwater platform. The smart mice, however, went +straight to the hidden platform on the first try. + +Since then, researchers have been able to confirm these results in +other labs and create even smarter strains of mice. In 2009, Dr. Tsien +published a paper announcing yet another strain of smart mice, dubbed +“Hobbie-J” (named after a character in Chinese cartoons). Hobbie-J was +able to remember novel facts (such as the location of toys) three times" +"longer than the genetically modified strain of mouse previously thought +to be the smartest. “This adds to the notion that NR2B is a universal +switch for memory formation,” remarked Dr. Tsien. “It’s like taking +Michael Jordon and making him a super Michael Jordan,” said graduate +student Deheng Wang. + +There are limits, however, even to this new mice strain. When these +mice were given a choice to take a left or right turn to get a chocolate +reward, Hobbie-J was able to remember the correct path for much +longer than the normal mice, but after five minutes he, too, forgot. “We +can never turn it into a mathematician. They are rats, after all,” says Dr. +Tsien. + +It should also be pointed out that some of the strains of smart mice +were exceptionally timid compared to normal mice. Some suspect that, if +your memory becomes too great, you also remember all the failures and +hurts as well, perhaps making you hesitant. So there is also a potential +downside to remembering too much." +"Next, scientists hope to generalize their results to dogs, since we share +so many genes, and perhaps also to humans. + +SMART FLIES AND DUMB MICE + +The NR2B gene is not the only gene being studied by scientists for its +impact on memory. In yet another groundbreaking series of experiments, +scientists have been able to breed a strain of fruit flies with +“photographic memory,” and also a strain of mice that are amnesiac. +These experiments may eventually explain many mysteries of our long¬ +term memory, such as why cramming for an exam is not the best way to + + study, and why we remember events if they are emotionally charged. +Scientists have found that there are two important genes, the CREB +activator (which stimulates the formation of new connections between +neurons) and the CREB repressor (which suppresses the formation of +new memories)." +"Dr. Jerry Yin and Timothy Tully of Cold Spring Harbor have been +doing interesting experiments with fruit flies. Normally it takes ten trials +for them to learn a certain task (e.g., detecting an odor, avoiding a +shock). Fruit flies with an extra CREB repressor gene could not form + +lasting memories at all, but the real surprise came when they tested fruit +flies with an extra CREB activator gene. They learned the task in just one +session. “This implies these flies have a photographic memory,” says Dr. +Tully. He said they are just like students “who could read a chapter of a +book once, see it in their mind, and tell you that the answer is in +paragraph three of page two seventy-four.”" +"This effect is not just restricted to fruit flies. Dr. Alcino Silva, also at +Cold Spring Harbor, has been experimenting with mice. He found that +mice with a defect in their CREB activator gene were virtually incapable +of forming long-term memories. They were amnesiac mice. But even +these forgetful mice could learn a bit if they had short lessons with rest +in between. Scientists theorize that we have a fixed amount of CREB +activator in the brain that can limit the amount we can learn in any +specific time. If we try to cram before a test, it means that we quickly +exhaust the amount of CREB activators, and hence we cannot learn any +more—at least until we take a break to replenish the CREB activators. + +“We can now give you a biological reason why cramming doesn’t +work,” says Dr. Tully. The best way to prepare for a final exam is to +mentally review the material periodically during the day, until the +material becomes part of your long-term memory." +"This may also explain why emotionally charged memories are so vivid +and can last for decades. The CREB repressor gene is like a filter, +cleaning out useless information. But if a memory is associated with a +strong emotion, it can either remove the CREB repressor gene or increase +levels of the CREB activator gene. + +In the future, we can expect more breakthroughs in understanding the +genetic basis of memory. Not just one but a sophisticated combination of +genes is probably required to shape the enormous capabilities of the +brain. These genes, in turn, have counterparts in the human genome, so +it is a distinct possibility that we can also enhance our memory and +mental skills genetically." +"However, don’t think that you will be able to get a brain boost +anytime soon. Many hurdles still remain. First, it is not clear if these +results apply to humans. Often therapies that show great promise in +mice do not translate well to our species. Second, even if these results +can be applied to humans, we do not know what their impact will be. +For example, these genes may help improve our memory but not affect" +"our general intelligence. Third, gene therapy (i.e., fixing broken genes) is +more difficult than previously thought. Only a small handful of genetic +diseases can be cured with this method. Even though scientists use +harmless viruses to infect cells with the “good” gene, the body still sends +antibodies to attack the intruder, often rendering the therapy useless. It’s +possible that the insertion of a gene to enhance memory would face a +similar fate. (In addition, the field of gene therapy suffered a major +setback a few years ago when a patient died at the University of +Pennsylvania during a gene therapy procedure. The work of modifying +human genes therefore faces many ethical and even legal questions.)" +"Human trials, then, will progress much more slowly than animal trials. +However, one can foresee the day when this procedure might be +perfected and become a reality. Altering our genes in this way would +require no more than a simple shot in the arm. A harmless virus would +then enter our blood, which would then infect normal cells by injecting +its genes. Once the “smart gene” is successfully incorporated into our +cells, the gene becomes active and releases proteins that would increase +our memory and cognitive skills by affecting the hippocampus and +memory formation. + +If the insertion of genes becomes too difficult, another possibility is to +insert the proper proteins directly into the body, bypassing the use of +gene therapy. Instead of getting a shot, we would swallow a pill. + +A SMART PILL" +"A SMART PILL + +Ultimately, one goal of this research is to create a “smart pill” that could +boost concentration, improve memory, and maybe increase our +intelligence. Pharmaceutical companies have experimented with several +drugs, such as MEM 1003 and MEM 1414, that do seem to enhance +mental function. + +Scientists have found that in animal studies, long-term memories are +made possible by the interaction of enzymes and genes. Learning takes +place when certain neural pathways are reinforced as specific genes are +activated, such as the CREB gene, which in turn emits a corresponding +protein. Basically, the more CREB proteins circulating in the brain, the + + faster long-term memories are formed. This has been verified in studies + +on sea mollusks, fruit flies, and mice. The key property of MEM 1414 is +that it accelerates the production of the CREB proteins. In lab tests, aged +animals given MEM 1414 were able to form long-term memories +significantly faster than a control group." +"Scientists are also beginning to isolate the precise biochemistry +required in the formation of long-term memories, at both the genetic and +the molecular level. Once the process of memory formation is completely +understood, therapies will be devised to accelerate and strengthen this +key process. Not only the aged and Alzheimer’s patients but eventually +the average person may well benefit from this “brain boost.” + +CAN MEMORIES BE ERASED?" +"CAN MEMORIES BE ERASED? + +Alzheimer’s may destroy memories indiscriminately, but what about +selectively erasing them? Amnesia is one of Hollywood’s favorite plot +devices. In The Bourne Identity, Jason Bourne (played by Matt Damon), a +skilled CIA agent, is found floating in the water, left for dead. When he +is revived, he has severe memory loss. He is being relentlessly chased by +assassins who want to kill him, but he does not know who he is, what +happened, or why they want him dead. The only clue to his memory is +his uncanny ability to instinctively engage in combat like a secret agent." +"It is well documented that amnesia can occur accidentally through +trauma, such as a blow on the head. But can memories be selectively +erased? In the film Eternal Sunshine of the Spotless Mind, starring Jim +Carrey, two people meet accidentally on a train and are immediately +attracted to each other. However, they are shocked to find that they +were actually lovers years ago but have no memory of it. They learn that +they paid a company to wipe memories of each other after a particularly +bad fight. Apparently, fate has given them a second chance at love. + +Selective amnesia was taken to an entirely new level in Men in Black, +in which Will Smith plays an agent from a shadowy, secret organization +that uses the “neuralizer” to selectively erase inconvenient memories of +UFOs and alien encounters. There is even a dial to determine how far +back the memories should be erased. + +All these make for thrilling plot lines and box-office hits, but are any +of them really possible, even in the future?" +"We know that amnesia is, indeed, possible, and that there are two +basic types, depending on whether short- or long-term memory has been +affected. “Retrograde amnesia” occurs when there is some trauma or +damage to the brain and preexisting memories are lost, usually dating +from the event that caused the amnesia. This would be similar to the +amnesia faced by Jason Bourne, who lost all memories from before he +was left for dead in the water. Here the hippocampus is still intact, so +new memories can be formed even though long-term memory has been +damaged. “Anterograde amnesia” occurs when short-term memory is +damaged, so the person has difficulty forming new memories after the +event that caused the amnesia. Usually, amnesia may last for minutes to +hours due to damage to the hippocampus. (Anterograde amnesia was +featured prominently in the movie Memento, where a man is bent on +revenge for the death of his wife. The problem, however, is that his" +"revenge for the death of his wife. The problem, however, is that his +memory lasts only about fifteen minutes, so he has to continually write +messages on scraps of papers, photos, and even tattoos in order to +remember the clues he has uncovered about the murderer. By painfully +reading this trail of messages he has written to himself, he can +accumulate crucial evidence that he would have soon forgotten.)" +"The point here is that memory loss dates back to the time of the +trauma or disease, which would make the selective amnesia of +Hollywood highly improbable. Movies like Men in Black assume that +memories are stored sequentially, as in a hard disk, so you just hit the +“erase” button after a designated point in time. However, we know that +memories are actually broken up, with separate pieces stored in different +places in the brain. + +A FORGETFUL DRUG + +Meanwhile, scientists are studying certain drugs that may erase +traumatic memories that continue to haunt and disturb us. In 2009, +Dutch scientists, led by Dr. Merel Kindt, announced that they had found +new uses for an old drug called propranolol, which could act like a +“miracle” drug to ease the pain associated with traumatic memories. The +drug did not induce amnesia that begins at a specific point in time, but it +did make the pain more manageable—and in just three days, the study + +claimed." +"claimed. + +The discovery caused a flurry of headlines, in light of the thousands of +victims who suffer from PTSD (post-traumatic stress disorder). Everyone +from war veterans to victims of sexual abuse and horrific accidents could +apparently find relief from their symptoms. But it also seemed to fly in +the face of brain research, which shows that long-term memories are" +"encoded not electrically, but at the level of protein molecules. Recent +experiments, however, suggest that recalling memories requires both the +retrieval and then the reassembly of the memory, so that the protein +structure might actually be rearranged in the process. In other words, +recalling a memory actually changes it. This may be the reason why the +drug works: propranolol is known to interfere with adrenaline +absorption, a key in creating the long-lasting, vivid memories that often +result from traumatic events. “Propranolol sits on that nerve cell and +blocks it. So adrenaline can be present, but it can’t do its job,” says Dr. +James McGaugh of the University of California at Irvine. In other words, +without adrenaline, the memory fades." +"Controlled tests done on individuals with traumatic memories showed +very promising results. But the drug hit a brick wall when it came to the +ethics of erasing memory. Some ethicists did not dispute its +effectiveness, but they frowned on the very idea of a forgetfulness drug, +since memories are there for a purpose: to teach us the lessons of life. +Even unpleasant memories, they said, serve some larger purpose. The +drug got a thumbs-down from the President’s Council on Bioethics. Its +report concluded that “dulling our memory of terrible things [would] +make us too comfortable with the world, unmoved by suffering, +wrongdoing, or cruelty.... Can we become numb to life’s sharpest +sorrows without also becoming numb to its greatest joys?” + +Dr. David Magus of Stanford University’s Center for Biomedical Ethics +says, “Our breakups, our relationships, as painful as they are, we learn +from some of those painful experiences. They make us better people.”" +"Others disagree. Dr. Roger Pitman of Harvard University says that if a +doctor encounters an accident victim who is in intense pain, “should we +deprive them of morphine because we might be taking away the full +emotional experience? Who would ever argue with that? Why should +psychiatry be different? I think that somehow behind this argument +lurks the notion that mental disorders are not the same as physical + +disorders.” + +How this debate is ultimately resolved could have direct bearing on +the next generation of drugs, since propranolol is not the only one +involved. + +In 2008, two independent groups, both working with animals, +announced other drugs that could actually erase memories, not just +manage the pain they cause. Dr. Joe Tsien of the Medical College of +Georgia and his colleagues in Shanghai stated that they had actually +eliminated a memory in mice using a protein called CaMKII, while +scientists at SUNY Downstate Medical Center in Brooklyn found that the" +"molecule PKMzeta could also erase memories. Dr. Andre Fenson, one of +the authors of this second study, said, “If further work confirms this +view, we can expect to one day see therapies based on PKMzeta memory +erasure.” Not only may the drug erase painful memories, it also “might +be useful in treating depression, general anxiety, phobias, post-traumatic +stress, and addictions,” he added. + +So far, research has been limited to animals, but human trials will +begin soon. If the results transfer from animals to humans, then a +forgetful pill may be a real possibility. It will not be the kind of pill seen +in Hollywood movies (which conveniently creates amnesia at a precise, +opportune time) but could have vast medical applications in the real +world for people haunted by traumatic memories. It remains to be seen, +though, how selective this memory erasure might be in humans. + +WHAT CAN GO WRONG?" +"WHAT CAN GO WRONG? + +There may come a day, however, when we can carefully register all the +signals passing through the hippocampus, thalamus, and the rest of the +limbic system and make a faithful record. Then, by feeding this +information into our brains, we might be able to reexperience the +totality of what another person went through. Then the question is: +What can go wrong? + +In fact, the implications of this idea were explored in a movie, +Brainstorm (1983), starring Natalie Wood, which was far ahead of its +time. In the movie, scientists create the Hat, a helmet full of electrodes +that can faithfully record all the sensations a person is experiencing." +"Later, a person can have precisely the same sensory experience by +playing that tape back into his brain. For fun, one person puts on the Hat +when he is making love and tape-records the experience. Then the tape +is put into a loop so the experience is greatly magnified. But when +another person unknowingly inserts the experience into his brain, he +nearly dies because of a sensory overload. Later, one of the scientists +experiences a fatal heart attack. But before she dies, she records her final +moments on tape. When another person plays the death tape into his +brain, he, too, has a sudden heart attack and dies. + +When news of this powerful machine finally leaks out, the military +wants to seize control. This sets off a power struggle between the +military, which views it as a powerful weapon, and the original +scientists, who want to use it to unlock the secrets of the mind. + +Brainstorm prophetically highlighted not only the promise of this" +"Brainstorm prophetically highlighted not only the promise of this + + technology but also its potential pitfalls. It was meant to be science +fiction, but some scientists believe that sometime in the future, these +very issues may play out in our headlines and in our courts. + +Earlier, we saw that there have been promising developments in +recording a single memory created by a mouse. It may take until mid¬ +century before we can reliably record a variety of memories in primates +and humans. But creating the Hat, which can record the totality of +stimulation entering into the brain, requires tapping into the raw, +sensory data surging up the spinal cord and into the thalamus. It may be +late in this century before this can be done. + +SOCIAL AND LEGAL ISSUES" +"SOCIAL AND LEGAL ISSUES + +Some aspects of this dilemma may play out in our lifetimes. On one +hand, we may reach a point where we can learn calculus by simply +uploading the skill. The educational system would be turned upside +down; perhaps it would free teachers to spend more time mentoring +students and giving them one-on-one attention in areas of cognition that +are less skill-based and cannot be mastered by hitting a button. The rote +memorization necessary to become a professional doctor, lawyer, or +scientist could also be drastically reduced through this method. + +In principle, it might even give us memories of vacations that never" +"In principle, it might even give us memories of vacations that never + +happened, prizes that we never won, lovers whom we never loved, or +families that we never had. It could make up for deficiencies, creating +perfect memories of a life never lived. Parents would love this, since +they could teach their children lessons taken from real memories. The +demand for such a device could be enormous. Some ethicists fear that +these fake memories would be so vivid that we would prefer to relive +imaginary lives rather than experiencing our real ones." +"The unemployed may also benefit from being able to learn new +marketable skills by having memories implanted. Historically, millions +of workers were left behind every time a new technology was +introduced, often without any safety net. That’s why we don’t have +many blacksmiths or wagon makers anymore. They turned into +autoworkers and other industrial workers. But retraining requires a large +amount of time and commitment. If skills can be implanted into the +brain, there would be an immediate impact on the world economic +system, since we wouldn’t have to waste so much human capital. (To +some degree, the value of a certain skill may be devalued if memories +can be uploaded into anyone, but this is compensated for by the fact that +the number and quality of skilled workers would vastly increase.)" +"The tourism industry will also experience a tremendous boost. One +barrier to foreign travel is the pain of learning new customs and +conversing with new phrases. Tourists would be able to share in the +experience of living in a foreign land, rather than getting bogged down +trying to master the local currency and the details of the transportation +system. (Although uploading an entire language, with tens of thousands +of words and expressions, would be difficult, it might be possible to +upload enough information to carry on a decent conversation.)" +"Inevitably, these memory tapes will find their way onto social media. +In the future, you might be able to record a memory and upload it to the +Internet for millions to feel and experience. Previously, we discussed a +brain-net through which you can send thoughts. But if memories can be +recorded and created, you might also be able to send entire experiences. +If you just won a gold medal at the Olympic Games, why not share the +agony and the ecstasy of victory by putting your memories on the web? +Maybe the experience will go viral and billions can share in your +moment’s glory. (Children, who are often at the forefront of video games +and social media, may make a habit of recording memorable experiences" +"and uploading them onto the Internet. Like taking a picture with a cell +phone, it would be second nature to them to record entire memories. +This would require both the sender and the receiver to have nearly +invisible nanowires connecting to their hippocampus. The information +would then be sent wirelessly to a server, which would convert the +message to a digital signal that can be carried by the Internet. In this +way, you could have blogs, message boards, social media, and chat +rooms where, instead of uploading pictures and videos, you would +upload memories and emotions.) + +A LIBRARY OF SOULS" +"A LIBRARY OF SOULS + +People may also want to have a geneology of memories. When searching +records of our ancestors, we see only a one-dimensional portrait of their +lives. Throughout human history, people have lived, loved, and died +without leaving a substantial record of their existence. Mostly we just +find the birth and death dates of our relatives, with little in between. +Today we leave a long trail of electronic documents (credit card receipts, +bills, e-mails, bank statements, etc.). By default, the web is becoming a +giant repository of all the documents that describe our lives, but this still +doesn’t tell anyone much about what we were thinking or feeling. +Perhaps in the far future, the web could become a giant library +chronicling not just the details of our lives but also our consciousness." +"In the future, people might routinely record their memories so their +descendants can share the same experiences. Visiting the library of +memories for your clan, you would be able to see and feel how they +lived, and also how you fit into the larger scheme of things. + +This means that anyone could replay our lives, long after we have +died, by hitting the “play” button. If this vision is correct, it means that +we might be able to “bring back” our ancestors for an afternoon chat, +simply by inserting a disk into the library and pushing a button. + +Meanwhile, if you want to share in the experiences of your favorite +historical figures, you might be able to have an intimate look into how +they felt as they confronted major crises in their lives. If you have a role +model and wish to know how they negotiated and survived the great +defeats of their life, you could experience their memory tapes and gain" +"valuable insight. Imagine being able to share the memories of a Nobel +Prize-winning scientist. You might get clues about how great discoveries +are made. Or you might be able to share the memories of great +politicians and statesmen as they made crucial decisions that affected +world history. + +Dr. Miguel Nicolelis believes all this will one day become reality. He +says, “Each of these perennial records would be revered as a uniquely +precious jewel, one among billions of equally exclusive minds that once +lived, loved, suffered, and prospered, until they, too, become +immortalized, not clad in cold and silent gravestones, but released +through vivid thoughts, intensely lived loves, and mutually endured +sorrows.” + +THE DARK SIDE OF TECHNOLOGY" +"THE DARK SIDE OF TECHNOLOGY + +Some scientists have pondered the ethical implications of this +technology. Almost every new medical discovery caused ethical concerns +when it was introduced. Some of them had to be restricted or banned +when proven harmful (like the sleeping drug thalidomide, which caused +birth defects). Others have been so successful they changed our +conception of who we are, such as test-tube babies. When Louise Brown, +the first test-tube baby, was born in 1978, it created such a media storm +that even the pope issued a document critical of this technology. But +today, perhaps your sibling, child, spouse, or even you may be a product +of in vitro fertilization. Like many technologies, eventually the public +will simply get used to the idea that memories can be recorded and +shared." +"Other bioethicists have different worries. What happens if memories +are given to us without our permission? What happens if these memories +are painful or destructive? Or what about Alzheimer’s patients, who are +eligible for memory uploads but are too sick to give permission? + +The late Bernard Williams, a philosopher at Oxford University, +worried that this device might disturb the natural order of things, which +is to forget. “Forgetting is the most beneficial process we possess,” he +says. + +If memories can be implanted like uploading computer files, it could" +"If memories can be implanted like uploading computer files, it could + +also shake the foundation of our legal system. One of the pillars of +justice is the eyewitness account, but what would happen if fake +memories were implanted? Also, if the memory of a crime can be +created, then it might secretly be implanted into the brain of an innocent +person. Or, if a criminal needs an alibi, he could secretly implant a +memory into another person’s brain, convincing him that they were +together when the crime was being committed. Furthermore, not just +verbal testimony but also legal documents would be suspect, since when +we sign affidavits and legal documents, we depend on our memory to +clarify what is true and false." +"Safeguards would have to be introduced. Laws will have to be passed +that clearly define the limits of granting or denying access to memories. +Just as there are laws limiting the ability of the police or third parties to +enter your home, there would be laws to prevent people from accessing +your memories without your permission. There would also have to be a +way to mark these memories so that the person realizes that they are +fake. Thus, he would still be able to enjoy the memory of a nice +vacation, but he would also know that it never happened." +"Taping, storing, and uploading our memories may allow us to record +the past and master new skills. But doing so will not alter our innate +ability to digest and process this large body of information. To do that, +we need to enhance our intelligence. Progress in this direction is +hindered by the fact that there is no universally accepted definition of +intelligence. However, there is one example of genius and intelligence +that no one can dispute, and that is Albert Einstein. Remarkably, sixty +years after his death, his brain is still yielding invaluable clues to the +nature of intelligence. + +Some scientists believe that, using a combination of electromagnetics, +genetics, and drug therapy, it may be possible to boost our intelligence +to the genius level. They cite the fact that random injuries to the brain +have been documented that can suddenly change a person of normal +ability into a “savant,” one whose spectacular mental and artistic ability" +"is off the scale. This can be achieved now by random accidents, but what +happens when science intervenes and illuminates the secret of this +process? + +The brain is wider than the sky +For, put them side by side +The one the other will contain +With ease, and you beside. + +—EMILY DICKINSON + +Talent hits a target no one else can hit. Genius hits a target no +one else can see. + +—ARTHUR SCHOPENHAUER + +6 EINSTEIN’S BRAIN AND ENHANCING OUR +INTELLIGENCE + +Albert Einstein’s brain is missing. + +Or, at least it was for fifty years, until the heirs of the doctor who +spirited it away shortly after his death in 1955 finally returned it to the +National Museum of Health and Medicine in 2010. Analysis of his brain +may help clarify these questions: What is genius? How do you measure +intelligence and its relationship to success in life? There are also +philosophical questions: Is genius a function of our genes, or is it more a +question of personal struggle and achievement?" +"And, finally, Einstein’s brain may help answer the key question: Can +we boost our own intelligence? + +The word “Einstein” is no longer a proper noun that refers to a specific +person. It now simply means “genius.” The picture that the name +conjures up (baggy pants, flaming white hair, disheveled looks) is +equally iconic and instantly recognizable. + +The legacy of Einstein has been enormous. When some physicists in +2011 raised the possibility that he was wrong, that particles could break +the light barrier, it created a firestorm of controversy in the physics +world that spilled over into the popular press. The very idea that +relativity, which forms the cornerstone of modern physics, could be +wrong had physicists around the world shaking their heads. As expected, +once the result was recalibrated, Einstein was shown to be right once + + again. It is always dangerous to go up against Einstein." +"again. It is always dangerous to go up against Einstein. + +One way to gain insight into the question “What is genius?” is to +analyze Einstein’s brain. Apparently on the spur of the moment, Dr. +Thomas Harvey, the doctor at the Princeton hospital who was +performing the autopsy on Einstein, decided to secretly preserve his +brain, against the knowledge and wishes of Einstein’s family. + +Perhaps he preserved Einstein’s brain with the vague notion that one +day it might unlock the secret of genius. Perhaps he thought, like many + +others, that there was a peculiar part of Einstein’s brain that was the seat +of his vast intelligence. Brian Burrell, in his book Postcards from the Brain +Museum, speculates that perhaps Dr. Harvey “got caught up in the +moment and was transfixed in the presence of greatness. What he +quickly discovered was that he had bitten off more than he could chew.”" +"What happened to Einstein’s brain after that sounds more like a +comedy than a science story. Over the years, Dr. Harvey promised to +publish his results of analyzing Einstein’s brain. But he was no brain +specialist, and kept making excuses. For decades, the brain sat in two +large mason jars filled with formaldehyde and placed in a cider box, +under a beer cooler. He had a technician slice the brain into 240 pieces, +and on rare occasions he would mail a few to scientists who wanted to +study them. Once, pieces were mailed to a scientist at Berkeley in a +mayonnaise container." +"Forty years later, Dr. Harvey drove across the country in a Buick +Skylark carrying Einstein’s brain in a Tupperware container, hoping to +return it to Einstein’s granddaughter Evelyn. She refused to accept it. +After Dr. Harvey’s death in 2007, it was left to his heirs to properly +donate his collection of slides and portions of Einstein’s brain to science. +The history of Einstein’s brain is so unusual that a TV documentary was +filmed about it. + +(It should be pointed out that Einstein’s brain was not the only one to +be preserved for posterity. The brain of one of the greatest geniuses of +mathematics, Carl Friedrich Gauss, often called the Prince of +Mathematicians, was also preserved by a doctor a century earlier. Back +then, the anatomy of the brain was largely unexplored, and no +conclusions could be drawn other than the fact that it had unusually +large convolutions or folds.)" +"One might expect that Einstein’s brain was far beyond an ordinary +human’s, that it must have been huge, perhaps with areas that were +abnormally large. In fact, the opposite has been found (it is slightly +smaller, not larger, than normal). Overall, Einstein’s brain is quite + + ordinary. If a neurologist did not know that this was Einstein��s brain, he +probably would not give it a second thought. + +The only differences found in Einstein’s brain were rather minor. A +certain part of his brain, called the angular gyri, was larger than normal, +with the inferior parietal regions of both hemispheres 15 percent wider" +"than average. Notably, these parts of the brain are involved in abstract +thought, in the manipulation of symbols such as writing and +mathematics, and in visual-spatial processing. But his brain was still +within the norm, so it is not clear whether the genius of Einstein lay in +the organic structure of his brain or in the force of his personality, his +outlook, and the times. In a biography that I once wrote of Einstein, +titled Einstein’s Cosmos, it was clear to me that certain features of his life +were just as important as any anomaly in his brain. Perhaps Einstein +himself said it best when he said, “I have no special talents.... I am only +passionately curious.” In fact, Einstein would confess that he had to +struggle with mathematics in his youth. To one group of schoolchildren, +he once confided, “No matter what difficulties you may have with +mathematics, mine were greater.” So why was Einstein Einstein?" +"First, Einstein spent most of his time thinking via “thought +experiments.” He was a theoretical physicist, not an experimental one, +so he was continually running sophisticated simulations of the future in +his head. In other words, his laboratory was his mind." +"Second, he was known to spend up to ten years or more on a single +thought experiment. From the age of sixteen to twenty-six, he focused on +the problem of light and whether it was possible to outrace a light beam. +This led to the birth of special relativity, which eventually revealed the +secret of the stars and gave us the atomic bomb. From the age of twenty- +six to thirty-six, he focused on a theory of gravity, which eventually gave +us black holes and the big-bang theory of the universe. And then from +the age of thirty-six to the end of his life, he tried to find a theory of +everything to unify all of physics. Clearly, the ability to spend ten or +more years on a single problem showed the tenacity with which he +would simulate experiments in his head." +"Third, his personality was important. He was a bohemian, so it was +natural for him to rebel against the establishment in physics. Not every +physicist had the nerve or the imagination to challenge the prevailing +theory of Isaac Newton, which had held sway for two hundred years +before Einstein. + +Fourth, the time was right for the emergence of an Einstein. In 1905, +the old physical world of Newton was crumbling in light of experiments +that clearly suggested a new physics was about to be born, waiting for a + + genius to show the way. For example, the mysterious substance called + +radium glowed in the dark all by itself indefinitely, as if energy was +being created out of thin air, violating the theory of conservation of +energy. In other words, Einstein was the right man for the times. If +somehow it becomes possible to clone Einstein from the cells in his +preserved brain, I suspect that the clone would not be the next Einstein. +The historic circumstances must also be right to create a genius." +"The point here is that genius is perhaps a combination of being born +with certain mental abilities and also the determination and drive to +achieve great things. The essence of Einstein’s genius was probably his +extraordinary ability to simulate the future through thought +experiments, creating new physical principles via pictures. As Einstein +himself once said, “The true sign of intelligence is not knowledge, but +imagination.” And to Einstein, imagination meant shattering the +boundaries of the known and entering the domain of the unknown. + +All of us are born with certain abilities that are programmed into our +genes and the structure of our brains. That is the luck of the draw. But +how we arrange our thoughts and experiences and simulate the future is +something that is totally within our control. Charles Darwin himself once +wrote, “I have always maintained that, excepting fools, men did not +differ much in intellect, only in zeal and hard work.” + +CAN GENIUS BE LEARNED?" +"CAN GENIUS BE LEARNED? + +This rekindles the question, Are geniuses made or born? How does the +nature/nurture debate solve the mystery of intelligence? Can an ordinary +person become a genius? + +Since brain cells are notoriously hard to grow, it was once thought +that intelligence was fixed by the time we became young adults. But one +thing is becoming increasingly clear with new brain research: the brain +itself can change when it learns. Although brain cells are not being +added in the cortex, the connections between neurons are changing +every time a new task is learned. + +For example, scientists in 2011 analyzed the brains of London’s +famous taxicab drivers, who have to laboriously memorize twenty-five +thousand streets in the dizzying maze that makes up modern London. It +takes three to four years to prepare for this arduous test, and only half + + the trainees pass." +"the trainees pass. + +Scientists at University College London studied the brains of these +drivers before they took the test, and then tested them again three to +four years afterward. Those trainees who passed the test had a larger +volume of gray matter than before, in an area called the posterior and +the anterior hippocampus. The hippocampus, as we’ve seen, is where +memories are processed. (Curiously, tests also showed that these taxicab +drivers scored less than normal on processing visual information, so +perhaps there is a trade-off, a price to pay for learning this volume of +information.) + +“The human brain remains ‘plastic,’ even in adult life, allowing it to +adapt when we learn new tasks,” says Eleanor Maguire of the Wellcome +Trust, which funded the study. “This offers encouragement for adults +who want to learn new skills later in life.”" +"Similarly, the brains of mice that have learned many tasks are slightly +different from the brains of other mice that have not learned these tasks. +It is not so much that the number of neurons has changed, but rather +that the nature of the neural connections has been altered by the +learning process. In other words, learning actually changes the structure +of the brain. + +This raises the old adage “practice makes perfect.” Canadian +psychologist Dr. Donald Hebb discovered an important fact about the +wiring of the brain: the more we exercise certain skills, the more certain +pathways in our brains become reinforced, so the task becomes easier. +Unlike a digital computer, which is just as dumb today as it was +yesterday, the brain is a learning machine with the ability to rewire its +neural pathways every time it learns something. This is a fundamental +difference between a digital computer and the brain." +"This lesson applies not only to London taxicab drivers, but also to +accomplished concert musicians as well. According to psychologist Dr. K. +Anders Ericsson and colleagues, who studied master violinists at Berlin’s +elite Academy of Music, top concert violinists could easily rack up ten +thousand hours of grueling practice by the time they were twenty years +old, practicing more than thirty hours per week. By contrast, he found +that students who were merely exceptional studied only eight thousand +hours or fewer, and future music teachers practiced only a total of four +thousand hours. Neurologist Daniel Levitin says, “The emerging picture + +from such studies is that ten thousand hours of practice is required to +achieve the level of mastery associated with being a world-class expert— +in anything.... In study after study, of composers, basketball players, +fiction writers, ice skaters, concert pianists, chess players, master" +"criminals, and what have you, this number comes up again and again.” +Malcolm Gladwell, writing in the book Outliers, calls this the “10,000- +hour rule.” + +HOW DO YOU MEASURE INTELLIGENCE? + +But how do you measure intelligence? For centuries, any discussion of +intelligence relied on hearsay and anecdote. But now MRI studies have +shown that the principal activity of the brain while performing these +mathematical puzzles involves the pathway connecting the prefrontal +cortex (which engages in rational thought) with the parietal lobes +(which processes numbers). This correlates with the anatomical studies +of Einstein’s brain, which showed that his inferior parietal lobes were +larger than normal. So it is conceivable that mathematical ability +correlates with increased information flows between the prefrontal +cortex and the parietal lobes. But did the brain increase in size in this +area because of hard work and study, or was Einstein born that way? +The answer is still not clear." +"The key problem is that there is no uniformly accepted definition of +intelligence, let alone a consensus among scientists as to its origin. But +the answer may prove critical if we wish to enhance it. + +IQ EXAMS AND DR. TERMAN + +By default, the most widely used measure of intelligence is the IQ exam, +pioneered by Dr. Lewis Terman of Stanford University, who in 1916 +revised an earlier test devised by Alfred Binet for the French +government. For the next several decades, it became the gold standard +by which to measure intelligence. Terman, in fact, dedicated his life to +the proposition that intelligence could be measured and inherited, and +was the strongest predictor of success in life. + +Five years later, Terman started a landmark study on schoolchildren," +"Five years later, Terman started a landmark study on schoolchildren, + +The Genetic Studies of Genius. It was an ambitious project, whose scope +and duration were unprecedented back in the 1920s. It set the tone for +research in this field for an entire generation. He methodically +chronicled the successes and failures of these individuals throughout +their lives, compiling thick files of their achievements. These high-IQ +students were dubbed the “Termites.” + +At first, Dr. Terman’s idea seemed to be a resounding success. It" +"At first, Dr. Terman’s idea seemed to be a resounding success. It + + became the standard by which both children and other tests were +measured. During World War I, 1.7 million soldiers were given this test. +But over the years, a different profile began to slowly emerge. Decades +later, children who scored high on the IQ exam were only moderately +more successful than those who did not. Terman could proudly point to +some of his students who went on to win awards and secure well-paying +jobs. But he became increasingly disturbed by the large number of his +brightest students whom society would consider to be failures, taking +menial, dead-end jobs, engaging in crime, or leading lives on the +margins of society. These results were quite upsetting to Dr. Terman, +who had dedicated his life to proving that high IQ meant success in life. + +SUCCESS IN LIFE AND DELAYED GRATIFICATION" +"SUCCESS IN LIFE AND DELAYED GRATIFICATION + +A different approach was taken in 1972 by Dr. Walter Mischel, also of +Stanford, who analyzed yet another characteristic among children: the +ability to delay gratification. He pioneered the use of the “marshmallow +test,” that is, would children prefer one marshmallow now, or the +prospect of two marsh-mallows twenty minutes later? Six hundred +children, aged four to six, participated in this experiment. When Mischel +revisited the participants in 1988, he found that those who could delay +gratification were more competent than those who could not." +"In 1990, another study showed a direct correlation between those who +could delay gratification and SAT scores. And a study done in 2011 +indicated that this characteristic continued throughout a person’s life. +The results of these and other studies were eye-opening. The children +who exhibited delayed gratification scored higher on almost every +measure of success in life: higher-paying jobs, lower rates of drug +addiction, higher test scores, higher educational attainment, better social + +integration, etc." +"integration, etc. + +But what was most intriguing was that brain scans of these individuals +revealed a definite pattern. They showed a distinct difference in the way +the prefrontal cortex interacted with the ventral striatum, a region +involved in addiction. (This is not surprising, since the ventral striatum +contains the nucleus accumbens, known as the “pleasure center.” So +there seems to be a struggle here between the pleasure-seeking part of +the brain and the rational part to control temptation, as we saw in +Chapter 2.) + +This difference was no fluke. The result has been tested by many +independent groups over the years, with nearly identical results. Other +studies have also verified the difference in the frontal-striatal circuitry of + + the brain, which appears to govern delayed gratification. It seems that +the one characteristic most closely correlated with success in life, which +has persisted over the decades, is the ability to delay gratification." +"Although this is a gross simplification, what these brain scans show is +that the connection between the prefrontal and parietal lobes seems to +be important for mathematical and abstract thought, while the +connection between the prefrontal and limbic system (involving the +conscious control of our emotions and pleasure center) seems to be +essential for success in life. + +Dr. Richard Davidson, a neuroscientist at the University of Wisconsin- +Madison, concludes, “Your grades in school, your scores on the SAT, +mean less for life success than your capacity to co-operate, your ability +to regulate your emotions, your capacity to delay your gratification, and +your capacity to focus your attention. Those skills are far more +important—all the data indicate—for life success than your IQ or your +grades.” + +NEW MEASURES OF INTELLIGENCE" +"NEW MEASURES OF INTELLIGENCE + +Clearly there have to be new ways to measure intelligence and success in +life. IQ exams are not useless, but they measure only one limited form of +intelligence. Dr. Michael Sweeney, author of Brain: The Complete Mind, +notes, “Tests don’t measure motivation, persistence, social skills, and a +host of other attributes of a life that’s well lived.”" +"The problem with many of these standardized tests is that there may +also be a subconscious bias due to cultural influences. In addition, these +tests are evaluating only one particular form of intelligence, which some +psychologists call “convergent” intelligence. Convergent intelligence +focuses on one line of thought, ignoring the more complex “divergent” +form of intelligence, which involves measuring differing factors. For +example, during World War II, the U.S. Army Air Forces asked scientists +to devise a psychological exam that would measure a pilot’s intelligence +and ability to handle difficult, unexpected situations. One question was: +If you are shot down deep in enemy territory and must somehow make it +back to friendly lines, what do you do? The results contradicted +conventional thinking." +"Most psychologists expected that the air force study would show that +pilots with high IQs would score highly on this test as well. Actually, the +reverse was true. The pilots who scored highest were the ones with +higher levels of divergent thinking, who could see through many +different lines of thought. Pilots who excelled at this, for example, were +able to think up a variety of unorthodox and imaginative methods to + + escape after they were captured behind enemy lines." +"escape after they were captured behind enemy lines. + +The difference between convergent and divergent thinking is also +reflected in studies on split-brain patients, which clearly show that each +hemisphere of the brain is principally hardwired for one or the other. Dr. +Ulrich Kraft of Fulda, Germany, writes, “The left hemisphere is +responsible for convergent thinking and the right hemisphere for +divergent thinking. The left side examines details and processes them +logically and analytically but lacks a sense of overriding, abstract +connections. The right side is more imaginative and intuitive and tends +to work holistically, integrating pieces of an informational puzzle into a +whole.”" +"In this book, I take the position that human consciousness involves the +ability to create a model of the world and then simulate the model into +the future, in order to attain a goal. Pilots who demonstrated divergent +thinking were able to simulate many possible future events accurately +and with more complexity. Similarly, the children who mastered delayed +gratification in the famous marshmallow test appear to be the ones who +had the most ability to simulate the future, to see the long-term rewards +and not just the short-term, get-rich-quick schemes." +"A more sophisticated intelligence exam that directly quantifies a +person’s ability to simulate the future would be difficult but not +impossible to create. A person could be asked to create as many realistic +scenarios for the future as possible to win a game, with a score assigned +depending on the number of simulations the person can imagine and the +number of causal links involved with each one. Instead of measuring a +person’s ability to simply assimilate information, this new method would +measure a person’s ability to manipulate and mold this information to +achieve a higher goal. For example, a person might be asked to figure +out how to escape from a deserted island full of hungry wild animals and +poisonous snakes. He would have to list all the various ways to survive, +fend off the dangerous animals, and leave the island, creating an +elaborate causal tree of possible outcomes and futures." +"So we see that there is a common thread running through all this +discussion, and that is that intelligence seems to be correlated with the +complexity with which we can simulate future events, which correlates +with our earlier discussion of consciousness. + +But given the rapid advances taking place in the world’s laboratories +concerning electromagnetic fields, genetics, and drug therapies, is it +possible not just to measure our intelligence, but to enhance it as well— +to become another Einstein? + + BOOSTING OUR INTELLIGENCE + +This possibility was explored in the novel Flowers for Algernon (1958), +later made into the Academy Award-winning movie Charly (1968). In it, +we follow the sad life of Charly Gordon, who has an IQ of 68 and a +menial job in a bakery. He lives a simple life, fails to understand that his +fellow workers are constantly making fun of him, and does not even +know how to spell his own name." +"His only friend is Alice, a teacher who takes pity on him and tries to +teach him to read. But one day, scientists discover a new procedure that +can suddenly make ordinary mice intelligent. Alice hears about this and +decides to introduce Charly to these scientists, who agree to perform the +procedure on their first human subject. Within weeks, Charly has +noticeably changed. His vocabulary increases, he devours books from the + +library, he becomes something of a ladies’ man, and his room explodes +with modern art. Soon he begins to read about relativity and the +quantum theory, pushing the boundaries of advanced physics. He and +Alice even become lovers." +"But then the doctors notice that the mice have slowly lost their ability +and died. Realizing that he, too, might lose everything, Charly furiously +tries to use his superior intellect to find a cure, but instead he’s forced to +witness his own inexorable decline. His vocabulary shrinks, he forgets +mathematics and physics, and he slowly reverts back to his old self. In +the final scene, a heartbroken Alice watches as Charly plays with +children. + +The novel and movie, although poignant and critically acclaimed, +were dismissed as sheer science fiction. The plot was moving and +original, but the idea of boosting one’s intelligence was considered +preposterous. Brain cells cannot regenerate, scientists said, so this +movie’s plot was obviously impossible. + +But not anymore." +"But not anymore. + +Although it is still impossible to boost your intelligence, rapid +advances are being made in electromagnetic sensors, genetics, and stem +cells that may one day make this a real possibility. In particular, +scientific interest has focused on “autistic savants,” who possess +phenomenal, superhuman abilities that stagger the imagination. More +important, due to specific injuries to the brain, normal people can +rapidly acquire such near-miraculous powers. Some scientists even +believe that these uncanny abilities might be induced using +electromagnetic fields. + + SAVANTS: SUPER GENIUSES? + +A bullet went crashing through the skull of Mr. Z when he was nine +years old. It did not kill him, as his doctors feared, but wreaked +extensive damage to the left side of his brain, causing paralysis of the +right side of his body and leaving him permanently deaf and mute." +"However, the bullet also had a bizarre side effect. Mr. Z developed +supernormal mechanical abilities and a prodigious memory, typical of +“savants.” + +Mr. Z is not alone. In 1979, a ten-year-old boy named Orlando Serrell +was knocked unconscious by a baseball that hit the left side of his head. +At first, he complained of severe headaches. But after the pain subsided, +he was able to do remarkable mathematical calculations and had a near¬ +photographic memory of certain events happening in his life. He could +calculate dates thousands of years into the future. + +In the entire world of roughly seven billion people, there are only +about one hundred documented cases of these astounding savants. (The +number is much larger if we include those whose mental skills are still +extraordinary but not superhuman. It is believed that about 10 percent +of autistic individuals show some savant capabilities.) These +extraordinary savants possess abilities far beyond our current scientific +understanding." +"There are several types of savants that have recently elicited the +curiosity of scientists. About half of savants have some form of autism +(the other half display other forms of mental illness or psychological +disorder). They often have profound problems interacting socially, +leading to deep isolation. + +Then there is the “acquired savant syndrome,” in which people who +appear perfectly normal suffer from some extreme trauma later in life +(e.g., hitting their head on the bottom of a swimming pool or being +struck by a baseball or a bullet), almost always on the left side of their +brain. Some scientists, however, suggest that this distinction is +misleading, that perhaps all savant skills are acquired. Since autistic +savants begin to show their abilities around age three or four, perhaps +their autism (like a blow to their head) is the origin of their abilities." +"There is scientific disagreement about the origin of these extraordinary +abilities. Some believe that these individuals are simply born this way +and hence are unique, one-of-a-kind anomalies. Their skills, even if + + awakened by a bullet, are hardwired into their brains from birth. If so, +then perhaps this skill can never be learned or transferred. + +Others claim that such hardwiring violates the theory of evolution, +which takes place incrementally over long periods of time. If savant +geniuses exist, then the rest of us must also possess similar abilities, +although they are latent. Does this mean, then, that one day we might be +able to turn on these miraculous powers at will? Some believe so, and +there are even published papers claiming that some savant skills are" +"latent in all of us and can be brought to light using the magnetic fields +generated by an electromagnetic scanner (TES). Or perhaps there is a +genetic basis to this skill, in which case gene therapy might re-create +these astonishing abilities. It might also be possible to cultivate stem +cells that would allow neurons to grow in the prefrontal cortex and other +key centers of the brain. Then we might be able to increase our mental +abilities. + +All these avenues are the source of much speculation and research. +Not only might they allow doctors to reverse the ravages of diseases like +Alzheimer’s, but they could also enable us to enhance our own +intelligence. The possibilities are intriguing." +"The first documented case of a savant was recorded in 1789 by Dr. +Benjamin Rush, who studied an individual who seemed to be mentally +handicapped. Yet when he was asked how many seconds a man had +lived (who was seventy years, seventeen days, and twelve hours old), it +took him only ninety seconds to give the correct answer of +2,210,500,800. + +Dr. Darold Treffert, a Wisconsin physician, has studied these savants at +length. He recites one story of a blind savant who was asked a simple +question. If you put one corn kernel in the first square of a chess board, +two kernels in the second, four in the next, and keep doubling after that, +how many kernels would you have on the sixty-fourth square? It took +him just forty-five seconds to correctly reply: +18,446,744,073,709,551,616." +"Perhaps the best-known example of a savant was the late Kim Peek, +who was the inspiration for the movie Rain Man, starring Dustin +Hoffman and Tom Cruise. Although Kim Peek was severely mentally +handicapped (he was incapable of living by himself and could barely tie +his shoelaces or button his shirt), he memorized about twelve thousand +books and could recite lines from them, word for word, on any particular +page. It took him about eight seconds to read a page. (He could +memorize a book in about half an hour, but he read them in an unusual +way. He could read both pages simultaneously, using each eye to read a + + different page at the same time.) Although incredibly shy, he eventually +began to enjoy performing dazzling feats of mathematics before curious +onlookers, who would try to challenge him with tricky questions. + +Scientists, of course, have to be careful in distinguishing true savant" +"skills from simple memorization tricks. Their skills are not just +mathematical—they also extend to incredible musical, artistic, and +mechanical capabilities. Since autistic savants have great difficulty +verbally expressing their mental processes, another avenue is to +investigate individuals who have Asperger’s syndrome, which is a milder +form of autism. Only in 1994 was Asperger’s syndrome recognized as a +distinct psychological condition, so there is very little solid research in +this area. Like autistic individuals, people with Asperger’s have a +difficult time interacting socially with others. However, with proper +training, they can learn enough social skills to hold down a job and +articulate their mental processes. And a fraction of them have +remarkable savant skills. Some scientists believe that many great +scientists had Asperger’s syndrome. This might explain the strange, +reclusive nature of physicists like Isaac Newton and Paul Dirac (one of" +"reclusive nature of physicists like Isaac Newton and Paul Dirac (one of +the founders of the quantum theory). Newton, in particular, was +pathologically incapable of small talk." +"I had the pleasure of interviewing one such individual, Daniel +Tammet, who has written a best seller, Bom on a Blue Day. Almost alone +among these remarkable savants, he is able to articulate his thoughts in +books, on the radio, and in TV interviews. For someone who had such +difficulty relating to others as a child, he now has a superb grasp of +communication skills. + +Daniel has the distinction of setting a world record for memorizing pi, +a fundamental number in geometry. He was able to memorize it to +22,514 decimal places. I asked him how he prepared for such a +herculean feat. Daniel told me that he associates a color or texture with +every number. Then I asked him the key question: If every digit has a +color or texture, then how does he remember tens of thousands of them? +Sadly, at that point he said he doesn’t know. It just comes to him. +Numbers have been his life ever since he was a child, and hence they +simply appear in his mind. His mind is a constant mixture of numbers +and colors." +"ASPERGER’S AND SILICON VALLEY + +So far, this discussion may seem abstract, without any direct bearing on + + our daily lives. But the impact of people with mild autism and Asperger’s +may be more widespread than previously thought, especially in certain +high-tech fields. + +In the hit television series The Big Bang Theory, we follow the antics of +several young scientists, mainly nerdy physicists, in their awkward quest +for female companionship. In every episode, there is a hilarious incident +that reveals how clueless and pathetic they are in this endeavor." +"There is a tacit assumption running through the series that their +intellectual brilliance is matched only by their geekiness. And +anecdotally, people have noticed that among the high-tech gurus in +Silicon Valley, a higher percentage than normal seem to lack some social +skills. (There is a saying among women scientists who attend highly +specialized engineering universities, where the girl-to-guy ratio is +decidedly in their favor: “The odds are good, but the goods are odd.”) + +Scientists set out to investigate this suspicion. The hypothesis is that +people with Asperger’s and other mild forms of autism have mental skills +ideally suited for certain fields, like the information technology industry. +Scientists at University College London examined sixteen people who +were diagnosed with a mild form of autism and compared them with +sixteen normal individuals. Both groups were shown slides containing +random numbers and letters arranged in increasingly complex patterns." +"Their results showed that people with autism had a superior ability to +focus on the task. In fact, as the tasks became harder, the gap between +the intellectual skills of both groups began to widen, with the autistic +individuals performing significantly better than the control group. (The +test, however, also showed that these individuals were more easily +distracted by outside noises and blinking lights than the control group.) + +Dr. Nilli Lavie says, “Our study confirms our hypothesis that people +with autism have higher perceptual capacity compared to the typical +population.... People with autism are able to perceive significantly more +information than the typical adult.” + +This certainly does not prove that all people who are intellectually +brilliant have some form of Asperger’s. But it does indicate that fields +requiring the ability to focus intellectually might have a higher +proportion of people with Asperger’s. + +BRAIN SCANS OF SAVANTS" +"BRAIN SCANS OF SAVANTS + + The subject of savants has always been shrouded in hearsay and amazing +anecdotal stories. But recently, the entire field has been turned upside +down with the development of MRI and other brain scans. + +Kim Peek’s brain, for example, was unusual. MRI scans show that it +lacked the corpus callosum connecting the left and right brain, which is +probably why he could read two pages at the same time. His poor motor +skills were reflected in a deformed cerebellum, the area that controls +balance. Unfortunately, MRI scans could not reveal the exact origin of +his extraordinary abilities and photographic memory. But in general, +brain scans have shown that many suffering from acquired savant +syndrome have experienced damage to their left brain." +"In particular, interest has focused on the left anterior temporal and +orbitofrontal cortices. Some believe that perhaps all savant skills +(autistic, acquired, and Asperger’s) arise from damage to this very +specific spot in the left temporal lobe. This area can act like a “censor” +that periodically flushes out irrelevant memories. But after damage +occurs to the left hemisphere, the right hemisphere starts to take over. +The right brain is much more precise than the left brain, which often +distorts reality and confabulates. In fact, it is believed that the right +brain must work extra hard because of damage to the left brain, and +hence savant skills develop as a consequence. For example, the right +brain is much more artistic than the left brain. Normally, the left brain +restricts this talent and holds it in check. But if the left brain is injured in +a certain way, it may unleash the artistic abilities latent in the right +brain, causing an explosion of artistic talent. So the key to unleashing" +"brain, causing an explosion of artistic talent. So the key to unleashing +savant capabilities might be to dampen the left brain so that it can no +longer restrain the natural talents of the right brain. This is sometimes +referred to as “left brain injury, right brain compensation.”" +"In 1998, Dr. Bruce Miller of the University of California at San +Francisco performed a series of studies that seem to back this idea up. +He and coworkers studied five normal individuals who began to show +signs of frontotemporal dementia (FTD). As their dementia started to +progress, savant abilities gradually began to emerge. As their dementia +got worse, several of these individuals began to exhibit even more +extraordinary artistic ability, although none had shown gifts in this area + +before. Moreover, the abilities they exhibited were typical of savant +behavior. Their abilities were visual, not auditory, and their artworks, +remarkable as they were, were just copies lacking any original, abstract, +or symbolic qualities. (One patient actually got better during the study. +But her emerging savant skills were also reduced as a consequence. This +suggests a close relationship between emerging disorders of the left +temporal lobe and emerging savant skills.)" +"Dr. Miller’s analysis seemed to show that degeneration of the left +anterior temporal and orbitofrontal cortices probably decreased +inhibition of the visual systems in the right hemisphere, thereby +increasing artistic abilities. Again, damaging the left hemisphere in a +particular location forced the right hemisphere to take over and develop." +"In addition to the savants, MRI scans have also been done on people +with hyperthymestic syndrome, who also have photographic memories. +These people do not suffer from autism and mental disorders, but they +share some of their skills. In the entire United States, there are only four +documented cases of true photographic memory. One of them is Jill +Price, a school administrator in Los Angeles. She can recall precisely +what she was doing on any particular day going back decades. But she +complains that she finds it difficult to erase certain thoughts. Indeed, her +brain seems to be “stuck on autopilot.” She compares her memory to +watching the world through a split screen, in which the past and present +are constantly competing for her attention." +"Since 2000, scientists at the University of California at Irvine have +scanned her brain, and they’ve found it to be unusual. Several regions +were larger than normal, such as the caudate nuclei (which is involved +with forming habits) and the temporal lobe (which stores facts and +figures). It is theorized that these two areas work in tandem to create her +photographic memory. Her brain is therefore different from the brains of +savants who suffer an injury or damage to their left temporal lobe. The +reason is unknown, but it points to another path by which one may +obtain these fantastic mental abilities. + +CAN WE BECOME SAVANTS? + +All this raises the intriguing possibility that one might be able to + +deliberately deactivate parts of the left brain and thereby increase the +activity of the right brain, forcing it to acquire savant capabilities." +"We recall that transcranial magnetic stimulation, or TMS, allows one +to effectively silence parts of the brain. If so, then why can’t we silence +this part of the left anterior temporal and orbitofrontal cortices using the +TMS and turn on a savantlike genius at will? + +This idea has actually been tried. Dr. Allan Snyder of the University of +Sydney, Australia, made headlines a few years ago when he claimed +that, by applying the TMS to a certain part of the left brain, his subjects +could suddenly perform savantlike feats. By directing low-frequency +magnetic waves into the left hemisphere, one can in principle turn off" +"this dominant region of the brain so that the right hemisphere takes +over. Dr. Synder and his colleagues did an experiment with eleven male +volunteers. They applied the TMS to the subjects’ left frontotemporal +region while the subjects were performing tests involving reading and +drawing. This did not produce savant skills among the subjects, but two +of them had significant improvements in their ability to proofread words +and recognize duplicated words. In another experiment, Dr. R. L. Young +and his colleagues gave a battery of psychological tests to seventeen +individuals. The tests were specifically designed to test for savant skills. +(Tests of this sort analyze a person’s ability to memorize facts, +manipulate numbers and dates, create artwork, or perform music.) Five +of the subjects reported improvement in savantlike skills after treatment +with TMS." +"Dr. Michael Sweeney has observed, “When applied to the prefrontal +lobes, TMS has been shown to enhance the speed and agility of cognitive +processing. The TMS bursts are like a localized jolt of caffeine, but +nobody knows for sure how the magnets actually do their work.” These +experiments hint, but by no means prove, that silencing a part of the left +frontotemporal region could initiate some enhanced skills. These skills +are a far cry from savant abilities, and we should also be careful to point +out that other groups have looked into these experiments, and the results +have been inconclusive. More experimental work must be done, so it is +still too early to render a final judgment one way or the other. + +TMS probes are the easiest and most convenient instrument to use for +this purpose, since they can selectively silence various parts of the brain +at will without relying on brain damage and traumatic accidents. But it" +"should also be noted that TMS probes are still crude, silencing millions +of neurons at a time. Magnetic fields, unlike electrical probes, are not +precise but spread out over several centimeters. We know that the left +anterior temporal and orbitofrontal cortices are damaged in savants and +likely responsible, at least in some part, for their unique abilities, but +perhaps the specific area that must be dampened is an even smaller +subregion. So each jolt of TMS might inadvertently deactivate some of +the areas that need to remain intact in order to produce savantlike skills." +"In the future, with TMS probes we might be able to narrow down the +region of the brain involved with eliciting savant skills. Once this region +is identified, the next step would be to use highly accurate electrical +probes, like those used in deep brain stimulation, to dampen these areas +even more precisely. Then, with the push of a button, it might be +possible to use these probes to silence this tiny portion of the brain in +order to bring out savantlike skills. + + FORGETTING TO FORGET AND PHOTOGRAPHIC MEMORY + +Although savant skills may be initiated by some sort of injury to the left +brain (leading to right brain compensation), this still does not explain +precisely how the right brain can perform these miraculous feats of +memory. By what neural mechanism does photographic memory +emerge? The answer to this question may determine whether we can +become savants." +"Until recently, it was thought that photographic memory was due to +the special ability of certain brains to remember. If so, then it might be +difficult for the average person to learn these memory skills, since only +exceptional brains are capable of them. But in 2012, a new study showed +that precisely the opposite may be true. + +The key to photographic memory may not be the ability of remarkable +brains to learn; on the contrary, it may be their inability to forget. If this +is true, then perhaps photographic memory is not such a mysterious +thing after all. + +The new study was done by scientists at the Scripps Research Institute +in Florida who were working with fruit flies. They found an interesting +way in which these fruit flies learn, which may overturn a cherished idea + +of how memories are formed and forgotten. The fruit flies were exposed +to different smells and were given positive reinforcement (with food) or +negative reinforcement (with electric shocks)." +"The scientists knew that the neurotransmitter dopamine was important +to forming memories. To their surprise, they found that dopamine +actively regulates both the formation and the forgetting of new +memories. In the process of creating new memories, the dCAl receptor +was activated. By contrast, forgetting was initiated by the activation of +the DAMB receptor. + +Previously, it was thought that forgetting might be simply the +degradation of memories with time, which happens passively by itself. +This new study shows that forgetting is an active process, requiring +intervention by dopamine. + +To prove their point, they showed that by interfering with the action +of the dCAl and DAMB receptors, they could, at will, increase or +decrease the ability of fruit flies to remember and forget. A mutation in +the dCAl receptor, for example, impaired the ability of the fruit flies to +remember. A mutation in the DAMB receptor decreased their ability to +forget." +"The researchers speculate that this effect, in turn, may be partially +responsible for savants’ skills. Perhaps there is a deficiency in their +ability to forget. One of the graduate students involved in the study, +Jacob Berry, says, “Savants have a high capacity for memory. But maybe +it isn’t memory that gives them this capacity; maybe they have a bad +forgetting mechanism. This might also be the strategy for developing +drugs to promote cognition and memory—what about drugs that inhibit +forgetting as a cognitive enhancers?” + +Assuming that this result holds up in human experiments as well, it +could encourage scientists to develop new drugs and neurotransmitters +that are able to dampen the forgetting process. One might thus be able +to selectively turn on photographic memories when needed by +neutralizing the forgetting process. In this way, we wouldn’t have the +continuous overflow of extraneous, useless information, which hinders +the thinking of people with savant syndrome." +"What is also exciting is the possibility that the BRAIN project, which is +being championed by the Obama administration, might be able to +identify the specific pathways involved with acquired savant syndrome. + +Transcranial magnetic fields are still too crude to pin down the handful +of neurons that may be involved. But using nanoprobes and the latest in +scanning technologies, the BRAIN project might be able to isolate the +precise neural pathways that make possible photographic memory and +incredible computational, artistic, and musical skills. Billions of research +dollars will be channeled into identifying the specific neural pathways +involved with mental disease and other afflictions of the brain, and the +secret of savant skills may be revealed in the process. Then it might be +possible to take normal individuals and make savants out of them. This +has happened many times in the past because of random accidents. In +the future, this may become a precise medical process. Time will tell." +"So far, the methods analyzed here do not alter the nature of the brain +or the body. The hope is that through the use of magnetic fields, we will +be able to unleash the potential that already exists in our brains but is +latent. The philosophy underlying this idea is that we are all savants +waiting to happen, and it will just take some slight alteration of our +neural circuits to unleash this hidden talent. + +Yet another tactic is to directly alter the brain and the genes, using the +latest in brain science and also genetics. One promising method is to use +stem cells. + +STEM CELLS FOR THE BRAIN" +"STEM CELLS FOR THE BRAIN + + It was dogma for many decades that brain cells do not regenerate. It +seemed impossible that you could repair old, dying brain cells, or grow +new ones to boost your abilities, but all this changed in 1998. That year, +it was discovered that adult stem cells could be found in the +hippocampus, the olfactory bulb, and the caudate nucleus. In brief, stem +cells are the “mother of all cells.” Embryonic stem cells, for instance, can +readily develop into any other cell. Although each of our cells contains +all the genetic material necessary to construct a human being, only +embryonic stem cells have the ability to actually differentiate into any +type of cell in the body. + +Adult stem cells have lost that chameleon-like ability, but they can +still reproduce and replace old, dying cells. As far as memory +enhancement goes, interest has focused on adult stem cells in the" +"hippocampus. It turns out that thousands of new hippocampus cells are +born naturally each day, but most die soon afterward. However, it was +shown that rats that learned new skills retained more of their new cells. +A combination of exercise and mood-elevating chemicals can also boost +the survival rate of new hippocampus cells. It turns out that stress, on +the contrary, accelerates the death of new neurons." +"In 2007, a breakthrough occurred when scientists in Wisconsin and +Japan were able to take ordinary human skin cells, reprogram their +genes, and turn them into stem cells. The hope is that these stem cells, +either found naturally or converted using genetic engineering, can one +day be injected into the brains of Alzheimer’s patients to replace dying +cells. (These new brain cells, because they do not yet have the proper +connections, would not be integrated into the brain’s neural architecture. +This means that a person would have to relearn certain skills to +incorporate these fresh new neurons.) + +Stem cell research is naturally one of the most active areas in brain +research. “Stem cell research and regenerative medicine are in an +extremely exciting phase right now. We are gaining knowledge very fast +and many companies are being formed and are starting clinical trials in +different areas,” says Sweden’s Jonas Frisen of the Karolinska Institute. + +GENETICS OF INTELLIGENCE" +"GENETICS OF INTELLIGENCE + +In addition to stem cells, another avenue of exploration involves +isolating the genes responsible for human intelligence. Biologists note +that we are about 98.5 percent genetically identical to a chimpanzee, yet + + we live twice as long and have exploded in intellectual skills in the past +six million years. So among a handful of genes there must be the ones +responsible for giving us the human brain. Within a few years, scientists +will have a complete map of all these genetic differences, and the secret +to human longevity and enhanced intelligence may be found within this +tiny set. Scientists have focused on a few genes that possibly drove the +evolution of the human brain. + +So perhaps the clue to revealing the secret of intelligence lies in our +understanding of our apelike ancestors. This raises another question: Can +this research make possible the Planet of the Apes ?" +"In this long-running series of movies, a nuclear war destroys modern +civilization. Humanity is reduced to barbarism, but the radiation +somehow accelerates the evolution of the other primates, so that they +become the dominant species on the planet. They create an advanced +civilization, while humans are reduced to scruffy, smelly savages +roaming half naked in the forest. At best, humans become zoo animals. +The tables have turned on the humans, so the apes gawk at us outside +the bars of our cages." +"In the latest installment, The Rise of the Planet of the Apes, scientists are +looking for a cure for Alzheimer’s disease. Along the way, they stumble +on a virus that has the unintended consequence of increasing a +chimpanzee’s intelligence. Unfortunately, one of these enhanced apes is +treated cruelly when placed in a shelter for primates. Using his increased +intelligence, the ape breaks free, infects the other lab animals with the +virus to raise their intelligence, and then frees all of them from their +cages. Soon a caravan of shouting, intelligent apes runs amok on the +Golden Gate Bridge, completely overwhelming local and state police. +After a spectacular, harrowing confrontation with the authorities, the +movie ends with the apes peacefully finding refuge in a redwood forest +north of the bridge." +"Is such a scenario realistic? In the short term, no, but it can’t be ruled +out in the future, since scientists in the coming years should be able to +catalog all the genetic changes that created Homo sapiens. But many +more mysteries have to be solved before we have intelligent apes. + +One scientist who has been fascinated not by science fiction, but by +the genetics of what makes us “human,” is Dr. Katherine Pollard, an +expert in a field called “bioinformatics,” which barely existed a decade +ago. In this field of biology, instead of cutting open animals to +understand how they are put together, researchers use the vast power of +computers to mathematically analyze the genes in animals’ bodies. She +has been at the forefront of finding the genes that define the essence of +what separates us from the apes. Back in 2003, as a freshly minted Ph.D. + + from the University of California at Berkeley, she got her chance." +"from the University of California at Berkeley, she got her chance. + +“I jumped at the opportunity to join the international team that was +identifying the sequence of DNA bases, or ‘letters,’ in the genome of the +common chimpanzee,” she recalled. Her goal was clear. She knew that +only fifteen million base pairs, or “letters,” that make up our genome + +(out of three billion base pairs) separate us from the chimps, our closest +genetic neighbor. (Each “letter” in our genetic code refers to a nucleic +acid, of which there are four, labeled A,T,C, and G. So our genome +consists of three billion letters, arranged like ATTCCAGGG....) + +“I was determined to find them,” she wrote." +"“I was determined to find them,” she wrote. + +Isolating these genes could have enormous implications for our future. +Once we know the genes that gave rise to Homo sapiens, it becomes +possible to determine how humans evolved. The secret of intelligence +might lie in these genes. It might even be possible to accelerate the path +taken by evolution and even enhance our intelligence. But even fifteen +million base pairs is a huge number to analyze. How can you find a +handful of genetic needles out of this genetic haystack?" +"Dr. Pollard knew that most of our genome is made of “junk DNA” that +does not contain any genes and was largely unaffected by evolution. This +junk DNA slowly mutates at a known rate (roughly 1 percent of it +changes over four million years). Since we differ from the chimps in our +DNA by 1.5 percent, this means that we probably separated from the +chimpanzees about six million years ago. Hence there is a “molecular +clock” in each of our cells. And since evolution accelerates this mutation +rate, analyzing where this acceleration took place allows you to tell +which genes are driving evolution. + +Dr. Pollard reasoned that if she could write a computer program that +could find where most of these accelerated changes are located in our +genome, she could isolate precisely the genes that gave birth to Homo +sapiens. After months of hard work and debugging, she finally placed her +program into the giant computers located at the University of California +at Santa Cruz. Anxiously she awaited the results." +"When the computer printout finally arrived, it showed what she was +looking for: there are 201 regions of our genome showing accelerated +change. But the first one on her list caught her attention. + +“With my mentor David Haussler leaning over my shoulder, I looked +at the top hit, a stretch of 118 bases that together became known as +human accelerated region 1 (HAR1),” she recalled. + + She was ecstatic. Bingo! + +“We had hit the jackpot,” she would write. It was a dream come true. + +She was staring at an area of our genome containing only 118 base +pairs, with the largest divergence of mutations separating us from the + +apes. Of these base pairs, only eighteen mutations were altered since we +became human. Her remarkable discovery showed that a small handful +of mutations could be responsible for raising us from the swamp of our +genetic past." +"Next she and her colleagues tried to decipher the precise nature of this +mysterious cluster called HAR1. They found that HAR1 was remarkably +stable across millions of years of evolution. Primates separated from +chickens about three hundred million years ago, yet only two base pairs +differ between chimps and chickens. So HAR1 was virtually unchanged +for several hundred million years, with only two changes, in the letters G +and C. Yet in just six million years, HAR1 mutated eighteen times, +representing a huge acceleration in our evolution." +"But what was more intriguing was the role HAR1 played in controlling +the overall layout of the cerebral cortex, which is famous for its wrinkled +appearance. A defect in the HAR1 region causes a disorder called +“lissencephaly,” or “smooth brain,” causing the cortex to fold +incorrectly. (Defects in this region are also linked to schizophrenia.) +Besides the large size of our cerebral cortex, one of its main +characteristics is that it is highly wrinkled and convoluted, vastly +increasing its surface area and hence its computational power. Dr. +Pollard’s work showed that changing just eighteen letters in our genome +was partially responsible for one of the major, defining genetic changes +in human history, vastly increasing our intelligence. (Recall that the +brain of Carl Friedrich Gauss, one of the greatest mathematicians in +history, was preserved after his death and showed unusual wrinkling.)" +"Dr. Pollard’s list went even further and identified a few hundred other +areas that also showed accelerated change, some of which were already +known. FOX2, for example, is crucial for the development of speech, +another key characteristic of humans. (Individuals with a defective FOX2 +gene have difficulty making the facial movements necessary for speech.) +Another region called HAR2 gives our fingers the dexterity required to +manipulate delicate tools. + +Furthermore, since the genome of the Neanderthal has been +sequenced, it is possible to compare our genetic makeup with a species +even closer to us than the chimpanzees. (When analyzing the FOX2 gene +in Neanderthals, scientists found that we shared the same gene with + + them. This means that there is a possibility that the Neanderthal could + +vocalize and create speech, as we do.)" +"vocalize and create speech, as we do.) + +Another crucial gene is called ASPM, which is thought to be +responsible for the explosive growth of our brain capacity. Some +scientists believe that this and other genes may reveal why humans +became intelligent but the apes did not. (People with a defective version +of the ASPM gene often suffer from microcephaly, a severe form of +mental retardation, because they have a tiny skull, about the size of one +of our ancestors, Australopithecus.)" +"Scientists have tracked the number of mutations within the ASPM +gene and found that it has mutated about fifteen times in the last five to +six million years, since we separated from the chimpanzee. More recent +mutations in these genes seem to be correlated with milestones in our +evolution. For example, one mutation occurred over one hundred +thousand years ago, when modern humans emerged in Africa, +indistinguishable in appearance from us. And the last mutation was +5,800 years ago, which coincides with the introduction of the written +language and agriculture. + +Because these mutations coincide with periods of rapid growth in +intellect, it is tantalizing to speculate that ASPM is among the handful of +genes responsible for our increased intelligence. If this is true, then +perhaps we can determine whether these genes are still active today, and +whether they will continue to shape human evolution into the future." +"All this research raises a question: Can manipulating a handful of +genes increase our intelligence? + +Quite possibly. + +Scientists are rapidly determining the precise mechanism by which +these genes gave rise to intelligence. In particular, genetic regions and +genes like HAR1 and ASPM could help solve a mystery concerning the +brain. If there are roughly twenty-three thousand genes in your genome, +then how can they possibly control the connections linking one hundred +billion neurons, containing a quadrillion total connections (1 with fifteen +zeros after it)? It seems mathematically impossible. The human genome +is about a trillion times too small to code for all our neural connections. +So our very existence seems to be a mathematical impossibility. + +The answer may be that nature takes numerous shortcuts in creating +the brain. First, many neurons are connected randomly, so that a +detailed blueprint is not necessary, which means that these randomly" +"connected regions organize themselves after a baby is born and starts to +interact with the environment. + +And second, nature also uses modules that repeat themselves over and +over again. Once nature discovers something useful, she often repeats it. +This may explain why only a handful of genetic changes are responsible +for most of our explosive growth in intelligence in the last six million +years. + +Size does matter in this case, then. If we tweak the ASPM and a few +other genes, the brain might become larger and more complex, thereby +making it possible to increase our intelligence. (Increasing our brain size +is not sufficient to do this, since how the brain is organized is also +crucially important. But increasing the gray matter of our brain is a +necessary precondition to increasing our intelligence.) + +APES, GENES, AND GENIUS" +"APES, GENES, AND GENIUS + +Dr. Pollard’s research focused on areas of our genome that we share with +the chimpanzees but that are mutated. It is also possible that there are +areas in our genome found only in humans, independent of the apes. +One such gene was discovered recently, in November 2012. Scientists, +led by a team at the University of Edinburgh, isolated the RIM-941 gene, +which is the only gene ever discovered that is found strictly in Homo +sapiens and not in other primates. Also, geneticists can show that the +gene emerged between one and six million years ago (after the time +when humans and chimpanzees split about six million years ago)." +"Unfortunately, this discovery also set off a huge firestorm in science +newsletters and blogs as misleading headlines blared across the Internet. +Breathless articles appeared claiming that scientists had found a single +gene that could, in principle, make chimpanzees intelligent. The essence +of “humanness” had finally been isolated at the genetic level, the +headlines shouted. + +Reputable scientists soon stepped in and tried to calm things down. In +all likelihood, a series of genes, acting together in complex ways, is +responsible for human intelligence. No single gene can make a chimp +suddenly have human intelligence, they said. + +Although these headlines were highly exaggerated, they did raise a + +serious question: How realistic is Planet of the Apes ?" +"There are a series of complications. If the HAR1 and ASPM genes are +tweaked so that the size and structure of the chimp brain suddenly +expand, then a series of other genes would have to be modified as well. +First, you would have to strengthen the chimp’s neck muscles and +increase its body size to support the larger head. But a large brain would +be useless unless it could control fingers capable of exploiting tools. So +the HAR2 gene would also have to be altered to increase their dexterity. +But since chimps often walk on their hands, another gene would have to +be altered so that the backbone would straighten out and an upright +posture would free up the hands. Intelligence is also useless unless +chimps can communicate with other members of the species. So the +FOX2 gene would also have to be mutated so that humanlike speech +would become possible. And lastly, if you want to create a species of +intelligent apes, you would have to modify the birth canal, since it is not" +"intelligent apes, you would have to modify the birth canal, since it is not +large enough to accommodate the larger skull. You could either perform +caesarians to cut the fetus out or genetically alter the birth canal of the +chimps to accommodate the larger brain." +"After all these necessary genetic adjustments, we are left with a +creature that would look very much like us. In other words, it may be +anatomically impossible to create intelligent apes, as in the movies, +without their also mutating into something closely resembling human +beings. + +Clearly, creating intelligent apes is no simple matter, then. The +intelligent apes we see in Hollywood movies are actually monkey suits +with humans inside, or are computer-generated graphics, so all these +issues are conveniently brushed under the rug. But if scientists could +seriously use gene therapy to create intelligent apes, then they might +closely resemble us, with hands that can use tools, vocal cords that can +create speech, backbones that can support an upright posture, and large +neck muscles to support large heads, as we have." +"All this raises ethical issues as well. Although society may allow +genetic studies of apes, it may not tolerate the manipulation of +intelligent creatures that can feel pain and distress. These creatures, after +all, would be intelligent and articulate enough to complain about their +situation and their fate, and their views would be heard in society. + +Not surprisingly, this area of bioethics is so new that it is totally + +unexplored. The technology is not yet ready, but in the coming decades, +as we identify all the genes and their functions that separate us from the +apes, the treatment of these enhanced animals could become a key +question." +"We can see, therefore, that it is only a matter of time before all the +tiny genetic differences between us and the chimpanzees are carefully +sequenced, analyzed, and interpreted. But this still does not explain a +deeper question: What were the evolutionary forces that gave us this +genetic heritage after we separated from the apes? Why did genes like +ASPM, HAR1, and FOX2 develop in the first place? In other words, +genetics gives us the ability to understand how we became intelligent, +but it does not explain why this happened. + +If we can understand this issue, it might provide clues as to how we +might evolve in the future. This takes us to the heart of the ongoing +debate: What is the origin of intelligence? + +THE ORIGIN OF INTELLIGENCE + +Many theories have been proposed as to why humans developed greater +intelligence, going all the way back to Charles Darwin." +"According to one theory, the evolution of the human brain probably +took place in stages, with the earliest phase initiated by climate change +in Africa. As the weather cooled, the forests began to recede, forcing our +ancestors onto the open plains and savannahs, where they were exposed +to predators and the elements. To survive in this new, hostile +environment, they were forced to hunt and walk upright, which freed up +their hands and opposable thumbs to use tools. This in turn put a +premium on a larger brain to coordinate tool making. According to this +theory, ancient man did not simply make tools—“tools made man.”" +"Our ancestors did not suddenly pick up tools and become intelligent. It +was the other way around. Those humans who picked up tools could +survive in the grasslands, while those who did not gradually died off. +The humans who then survived and thrived in the grasslands were those +who, through mutations, became increasingly adept at tool making, +which required an increasingly larger brain. + +Another theory places a premium on our social, collective nature." +"Another theory places a premium on our social, collective nature. + +Humans can easily coordinate the behavior of over a hundred other +individuals involved in hunting, farming, warring, and building, groups +that are much larger than those found in other primates, which gave +humans an advantage over other animals. It takes a larger brain, +according to this theory, to be able to assess and control the behavior of +so many individuals. (The flip side of this theory is that it took a larger +brain to scheme, plot, deceive, and manipulate other intelligent beings +in your tribe. Individuals who could understand the motives of others + + and then exploit them would have an advantage over those who could +not. This is the Machiavellian theory of intelligence.)" +"Another theory maintains that the development of language, which +came later, helped accelerate the rise of intelligence. With language +comes abstract thought and the ability to plan, organize society, create +maps, etc. Humans have an extensive vocabulary unmatched by any +other animal, with words numbering in the tens of thousands for an +average person. With language, humans could coordinate and focus the +activities of scores of individuals, as well as manipulate abstract +concepts and ideas. Language meant you could manage teams of people +on a hunt, which is a great advantage when pursuing the woolly +mammoth. It meant you could tell others where game was plentiful or +where danger lurked." +"Yet another theory is “sexual selection,” the idea that females prefer to +mate with intelligent males. In the animal kingdom, such as in a wolf +pack, the alpha male holds the pack together by brute force. Any +challenger to the alpha male has to be soundly beaten back by tooth and +claw. But millions of years ago, as humans became gradually more +intelligent, strength alone could not keep the tribe together. Anyone +with cunning and intelligence could ambush, lie or cheat, or form +factions within the tribe to take down the alpha male. Hence the new +generation of alpha males would not necessarily be the strongest. Over +time, the leader would become the most intelligent and cunning. This is +probably the reason why females choose smart males (not necessarily +nerdy smart, but “quarterback smart”). Sexual selection in turn +accelerated our evolution to become intelligent. So in this case the +engine that drove the expansion of our brain would be females who" +"engine that drove the expansion of our brain would be females who +chose men who could strategize, become leaders of the tribe, and outwit +other males, which requires a large brain." +"These are just a few of the theories about the origin of intelligence, +and each has its pros and cons. The common theme seems to be the +ability to simulate the future. For example, the purpose of the leader is +to choose the correct path for the tribe in the future. This means any +leader has to understand the intentions of others in order to plan +strategy for the future. Hence simulating the future was perhaps one of +the driving forces behind the evolution of our large brain and +intelligence. And the person who can best simulate the future is the one +who can plot, scheme, read the minds of many of his fellow tribesmen, +and win the arms race with his fellow man. + +Similarly, language allows you to simulate the future. Animals possess +a rudimentary language, but it is mainly in the present tense. Their +language may warn them of an immediate threat, such as a predator +hiding among the trees. However, animal language apparently has no" +"future or past tense. Animals do not conjugate their verbs. So perhaps +the ability to express the past and future tense was a key breakthrough +in the development of intelligence. + +Dr. Daniel Gilbert, a psychologist at Harvard, writes, “For the first few +hundred million years after their initial appearance on our planet, our +brains were stuck in the permanent present, and most brains still are +today. But not yours and not mine, because two or three million years +ago our ancestors began a great escape from the here and now....” + +THE FUTURE OF EVOLUTION + +So far, we have seen that there are intriguing results indicating that one +can increase one’s memory and intelligence, largely by making the brain +more efficient and maximizing its natural capacity. A variety of methods +are being studied, such as certain drugs, genes, or devices (TES, for +example) that might increase the capabilities of our neurons." +"So the concept of altering the brain size and capacity of the apes is a +distinct, though difficult, possibility. Gene therapy on this scale is still +many decades away. But this raises another difficult question: How far +can this go? Can one extend the intelligence of an organism indefinitely? +Or is there a limit to brain modification imposed by the laws of physics? + +Surprisingly, the answer is yes. The laws of physics put an upper limit + +to what can be done with genetic modification of the human brain, +given certain restraints. To see this limit, it is instructive to first examine +whether evolution is still increasing human intelligence, and then what +can be done to accelerate this natural process." +"In popular culture, there is the notion that evolution will give us big +brains and small, hairless bodies in the future. Likewise, aliens from +space, because they are supposed to possess a superior level of +intelligence, are often portrayed in this fashion. Go to any novelty shop +and you will see the same extraterrestrial face, with big bug eyes, a huge +head, and green skin. + +Actually, there are indications that gross human evolution (i.e., our +basic body shape and intelligence) has largely come to a halt. There are +several factors supporting this. First of all, since we are bipedal +mammals who walk upright, there are limitations to the maximum size +of an infant’s skull that can pass through the birth canal. Second, the rise +of modern technology has removed many of the harsh evolutionary +pressures faced by our ancestors." +"However, evolution on a genetic and molecular basis continues +unabated. Although it’s difficult to see with the naked eye, there is +evidence that human biochemistry has changed to adjust to +environmental challenges, such as combating malaria in tropical areas. +Also, humans recently evolved enzymes to digest lactose sugar as we +learned to domesticate cows and drink milk. Mutations have occurred as +humans adjusted to a diet created by the agricultural revolution. +Moreover, people still choose to mate with others who are healthy and +fit, and so evolution continues to eliminate unsuitable genes at this level. +None of these mutations, however, has changed our basic body plan or +increased our brain size. (Modern technology is also influencing our +evolution to some degree. For example, there is no longer any selection +pressure on nearsighted people, since anyone today can be outfitted with +glasses or contact lenses.) + +PHYSICS OF THE BRAIN" +"PHYSICS OF THE BRAIN + +So from an evolutionary and biological point of view, evolution is no +longer selecting for more intelligent people, at least not as rapidly as it + +did thousands of years ago. + +There are also indications from the laws of physics that we have +reached the maximum natural limit of intelligence, so that any +enhancement of our intelligence would have to come from external +means. Physicists who have studied the neurology of the brain conclude +that there are trade-offs preventing us from getting much smarter. Every +time we envision a brain that is larger, or denser, or more complex, we +bump up against these negative trade-offs." +"The first principle of physics that we can apply to the brain is the +conservation of matter and energy; that is, the law stating that the total +amount of matter and energy in a system remains constant. In particular, +in order to carry out its incredible feats of mental gymnastics, the brain +has to conserve energy, and hence it takes many shortcuts. As we saw in +Chapter 1, what we see with our eyes is actually cobbled together using +energy-saving tricks. It would take too much time and energy for a +thoughtful analysis of every crisis, so the brain saves energy by making +snap judgments in the form of emotions. Forgetting is an alternative way +of saving energy. The conscious brain has access to only a tiny portion of +the memories that have an impact on the brain. + +So the question is: Would increased brain size or density of neurons +give us more intelligence?" +"So the question is: Would increased brain size or density of neurons +give us more intelligence? + + Probably not. “Cortical gray matter neurons are working with axons +that are pretty close to the physical limit,” says Dr. Simon Laughlin of +Cambridge University. There are several ways in which one can increase +the intelligence of the brain using the laws of physics, but each has its +own problems: + +• One can increase brain size and extend the length of neurons. The +problem here is that the brain now consumes more energy. This +generates more heat in the process, which is detrimental to our +survival. If the brain uses up more energy, it gets hotter, and tissue +damage results if the body temperature becomes too high. (The +chemical reactions of the human body and our metabolism require +temperatures to be in a precise range.) Also, longer neurons means +that it takes longer for signals to go across the brain, which slows +down the thinking process." +"• One can pack more neurons into the same space by making them + +thinner. But if neurons become thinner and thinner, the complex +chemical/electrical reactions that must take place inside the axons +fail, and eventually they begin to misfire more easily. Douglas Fox, +writing in Scientific American, says, “You might call it the mother of +all limitations: the proteins that neurons use to generate electrical +pulses, called ion channels, are inherently unstable.” + +• One can increase the speed of the signal by making the neurons +thicker. But this also increases energy consumption and generates +more heat. It also increases the size of the brain, which increases the +time it takes for the signals to reach their destination. + +• One can add more connections between neurons. But this again +increases energy consumption and heat generation, making the +brain larger and slower in the process." +"So each time we tinker with the brain, we are checkmated. The laws +of physics seem to indicate that we have maxed out the intelligence that +we humans can attain in this way. Unless we can suddenly increase the +size of our skulls or the very nature of neurons in our brains, it seems we +are at the maximum level of intelligence. If we are to increase our +intelligence, it has to be done by making our brains more efficient (via +drugs, genes, and possibly TES-type machines). + +PARTING THOUGHTS + +In summary, it may be possible in the coming decades to use a" +"PARTING THOUGHTS + +In summary, it may be possible in the coming decades to use a + + combination of gene therapy, drugs, and magnetic devices to increase +our intelligence. There are several avenues of exploration that are +revealing the secrets of intelligence and how it may be modified or +enhanced. But what would it do to society, though, if we could enhance +our intelligence and get a “brain boost”? Ethicists have seriously +contemplated this question, since the basic science is growing so rapidly. +The big fear is that society may bifurcate, with only the rich and +powerful having access to this technology, which they could use to +further solidify their exalted position in society. Meanwhile, the poor +won’t have access to additional brain power, making it more difficult to +move up in society." +"This is certainly a valid concern, but it flies in the face of the history +of technology. Many of the technologies of the past were indeed initially +the province of the rich and powerful, but eventually mass production, +competition, better transportation, and improvements in technology +drove down the costs, so the average person could afford them. (For +example, we take for granted that we eat foods for breakfast that the +king of England could not have procured a century ago. Technology has +made it possible to purchase delicacies from around the world at any +supermarket that would be the envy of the aristocrats of the Victorian +era.) So if it becomes possible to increase our intelligence, the price of +this technology will gradually fall. Technology is never the monopoly of +the privileged rich. Sooner or later ingenuity, hard work, and simple +market forces will drive down its cost." +"There is also the fear that the human race will split into those who +want their intelligence to be boosted and those who prefer to remain the +same, resulting in the nightmare of having a class of super-intelligent +brahmins lord over the masses of the less gifted. + +But again, perhaps the fear of boosting intelligence has been +exaggerated. The average person has absolutely no interest in being able +to solve the complex tensor equations for a black hole. The average +person sees nothing to gain by mastering the mathematics of +hyperspatial dimensions or the physics of the quantum theory. On the +contrary, the average person may find such activities rather boring and +useless. So most of us are not going to become mathematical geniuses if +given the opportunity, because it is not in our character, and we see +nothing to gain from it." +"Keep in mind that society already has a class of accomplished +mathematicians and physicists, and they are paid significantly less than +ordinary businessmen and wield much less power than average +politicians. Being super smart does not guarantee financial success in +life. In fact, being super smart may actually pigeonhole you in the lower +rungs of a society that values athletes, movie stars, comedians, and + + entertainers more. + +No one ever got rich doing relativity. + +Also, a lot depends on precisely which traits are enhanced. There are +other forms of intelligence besides using mathematics. (Some argue that +intelligence must include artistic genius as well. In this case, one can + +conceivably use this talent to make a comfortable living.)" +"conceivably use this talent to make a comfortable living.) + +Anxious parents of high school children may want to boost the IQ of +their kids as they prepare for standardized exams. But IQ, as we have +seen, does not necessarily correspond to success in life. Likewise, people +may want to enhance their memory, but, as we have seen with savants, +having a photographic memory can be a blessing as well as a curse. And +in both cases, enhancement is unlikely to contribute to a society splitting +in two. + +Society as a whole, however, may benefit from this technology. +Workers with an enhanced intelligence would be better prepared to face +an ever-changing job market. Retraining workers for the jobs of the +future would be less of a drain on society. Furthermore, the public will +be able to make informed decisions about major technological issues of +the future (e.g., climate change, nuclear energy, space exploration) +because they will grasp these complex issues better." +"Also, this technology may help even out the playing field. Children +today who go to exclusive private schools and have personal tutors are +better prepared for the job market because they have more opportunities +to master difficult materials. But if everyone has had their intelligence +enhanced, the fault lines within society will be evened out. Then how far +someone goes in life would be more related to their drive, ambition, +imagination, and resourcefulness rather than to being born with a silver +spoon in their mouth. + +In addition, raising our intelligence may help speed up technological +innovation. Increased intelligence would mean a greater ability to +simulate the future, which would be invaluable in making scientific +discoveries. Often, science stagnates in certain areas because of a lack of +fresh new ideas to stimulate new avenues of research. Having an ability +to simulate different possible futures would vastly increase the rate of +scientific breakthroughs." +"These scientific discoveries, in turn, could generate new industries, +which could enrich all of society, creating new markets, new jobs, and +new opportunities. History is full of technological breakthroughs +creating entirely new industries that benefited not just the few, but all of + + society (think of the transistor and the laser, which today form the +foundation of the world economy). + +However, in science fiction, there is the recurring theme of the super + +criminal, who uses his superior brain power to embark on a crime spree +and thwart the superhero. Every Superman has his Lex Luthor, every +Spider-Man has his Green Goblin. Although it is certainly possible that a +criminal mind will use a brain booster to create super weapons and plan +the crime of the century, realize that members of the police force can +also have their intelligence boosted to outwit the evil mastermind. So +super criminals are dangerous only if they are the only ones in +possession of enhanced intelligence." +"So far, we have examined the possibility that we can enhance or alter +our mental capabilities via telepathy, telekinesis, uploading memories, +or brain boosts. Such enhancement basically means modifying and +augmenting the mental capabilities of our consciousness. This tacitly +assumes that our normal consciousness is the only one, but I’d like to +explore whether there are different forms of consciousness. If so, there +could be other ways of thinking that lead to totally different outcomes +and consequences. Within our own thoughts, there are altered states of +consciousness, such as dreams, drug-induced hallucinations, and mental +illness. There is also nonhuman consciousness, the consciousness of +robots, and even that of aliens from outer space. We have to give up the +chauvinistic notion that our human consciousness is the only one. There +is more than one way to create a model of our world, and more than one +way to simulate its future." +"Dreams, for example, are one of the most ancient forms of +consciousness and were studied by the ancients, yet very little progress +has been made in understanding them until recently. Perhaps dreams are +not silly, random events spliced together by the sleeping brain but +phenomena that may give insight into the meaning of consciousness. +Dreams may be a key to understanding altered states of consciousness. + +BOOK III ALTEHED CONSCIOUSNESS + +The future belongs to those who believe in the beauty of their +dreams. + +—ELEANOR ROOSEVELT + + 7 IN YOUR DREAMS + +Dreams can determine destiny." +"—ELEANOR ROOSEVELT + + 7 IN YOUR DREAMS + +Dreams can determine destiny. + +Perhaps the most famous dream in antiquity took place in the year +A.D. 312, when the Roman emperor Constantine engaged in one of the +greatest battles of his life. Faced with a rival army twice the size of his +own, he realized that he probably would die in battle the next day. But +in a dream he had that night, an angel appeared before him bearing the +image of a cross, uttering the fateful words “By this symbol, you shall +conquer.” Immediately he ordered the shields of his troops adorned with +the symbol of the cross." +"History records that he emerged triumphant the next day, cementing +his hold on the Roman Empire. He vowed to repay the blood debt to this +relatively obscure religion, Christianity, that had been persecuted for +centuries by previous Roman emperors and whose adherents were +regularly fed to the lions in the Colosseum. He signed laws that would +eventually pave the way for it to become an official religion of one of +the greatest empires in the world." +"For thousands of years, kings and queens, as well as beggars and +thieves, have all wondered about dreams. The ancients considered +dreams to be omens about the future, so there have been countless +attempts throughout history to interpret them. The Bible records in +Genesis 41 the rise of Joseph, who was able to correctly interpret the +dreams of the Pharaoh of Egypt thousands of years ago. When the +Pharaoh dreamed about seven fat cows, followed by seven lean cows, he +was so disturbed by the imagery that he asked scribes and mystics +throughout the kingdom to find its meaning. All failed to give a +convincing explanation, until Joseph finally interpreted the dream to +mean that Egypt would have seven years of good harvests, followed by +seven years of drought and famine. So, said Joseph, Egypt must begin +stockpiling grain and supplies now, in preparation for the coming years +of want and desperation. When this came to pass, Joseph was considered + +to be a prophet." +"to be a prophet. + +Dreams have long been associated with prophesy, but in more recent +times they’ve also been known to stimulate scientific discovery. The idea +that neurotransmitters could facilitate the movement of information past +a synapse, which forms the foundation of neuroscience, came to +pharmacologist Otto Loewi in a dream. Similarly, in 1865, August +Kekule had a dream about benzene, in which the bonds of carbon atoms +formed a chain that eventually wrapped around and finally formed a + + circle, just like a snake biting its tail. This dream would unlock the +atomic structure of the benzene molecule. He concluded, “Let us learn to +dream!”" +"Dreams have also been interpreted as a window onto our true +thoughts and intentions. The great Renaissance writer and essayist +Michel de Montaigne once wrote, “I believe it to be true that dreams are +the true interpretations of our inclinations, but there is art required to +sort and understand them.” More recently, Sigmund Freud proposed a +theory to explain the origin of dreams. In his signature work, The +Interpretation of Dreams, he claimed that they were manifestations of our +subconscious desires, which were often repressed by the waking mind +but which run wild every night. Dreams were not just the random +figments of our overheated imaginations but could actually uncover +deep secrets and truths about ourselves. “Dreams are the royal road to +the unconscious,” he wrote. Since then, people have amassed huge +encyclopedias that claim to reveal the hidden meaning behind every +disturbing image in terms of Freudian theory." +"Hollywood takes advantage of our continuing fascination with dreams. +A favorite scene in many movies is when the hero experiences a +terrifying dream sequence and then suddenly wakes up from the +nightmare in a cold sweat. In the blockbuster movie Inception, Leonardo +DiCaprio plays a petty thief who steals intimate secrets from the most +unlikely of all places, people’s dreams. With a new invention, he is able +to enter people’s dreams and deceive them into giving up their financial +secrets. Corporations spend millions of dollars protecting industrial +secrets and patents. Billionaires jealously guard their wealth using +elaborate codes. His job is to steal them. The plot quickly escalates as +the characters enter dreams in which a person falls asleep and dreams +again. So these criminals descend deeper and deeper into multiple layers + +of the subconscious." +"of the subconscious. + +But although dreams have always haunted and mystified us, only in +the last decade or so have scientists been able to peel away the mysteries +of dreams. In fact, scientists can now do something once considered +impossible: they are able to take rough photographs and videotapes of +dreams with MRI machines. One day, you may be able to view a video of +the dream you had the previous night and gain insight into your own +subconscious mind. With proper training, you might be able to +consciously control the nature of your dreams. And perhaps, like +DiCaprio’s character, with advanced technology you might even be able +to enter someone else’s dream. + +THE NATURE OF DREAMS" +"THE NATURE OF DREAMS + + As mysterious as they are, dreams are not a superfluous luxury, the +useless ruminations of the idle brain. Dreams, in fact, are essential for +survival. Using brain scans, it is possible to show that certain animals +exhibit dreamlike brain activity. If deprived of dreams, these animals +would often die faster than they would by starvation, because such +deprivation severely disrupts their metabolism. Unfortunately, science +does not know exactly why this is the case. + +Dreaming is an essential feature of our sleep cycle as well. We spend +roughly two hours a night dreaming when we sleep, with each dream +lasting five to twenty minutes. In fact, we spend about six years +dreaming during an average lifetime." +"Dreams are also universal across the human race. Looking across +different cultures, scientists find common themes in dreams. Fifty +thousand dreams were recorded over a forty-year time period by +psychology professor Calvin Hall. He followed this up with one thousand +dream reports from college students. Not surprisingly, he found that +most people dreamed of the same things, such as personal experiences +from the previous days or week. (However, animals apparently dream +differently than we do. In the dolphin, for example, only one hemisphere +at a time sleeps in order to prevent drowning, because they are air- +breathing mammals, not fish. So if they dream, it is probably in only one +hemisphere at a time.)" +"The brain, as we have seen, is not a digital computer, but rather a +neural network of some sort that constantly rewires itself after learning +new tasks. Scientists who work with neural networks noticed something +interesting, though. Often these systems would become saturated after +learning too much, and instead of processing more information they +would enter a “dream” state, whereby random memories would +sometimes drift and join together as the neural networks tried to digest +all the new material. Dreams, then, might reflect “house cleaning,” in +which the brain tries to organize its memories in a more coherent way. +(If this is true, then possibly all neural networks, including all organisms +that can learn, might enter a dream state in order to sort out their +memories. So dreams probably serve a purpose. Some scientists have +speculated that this might imply that robots that learn from experience +might also eventually dream as well.)" +"Neurological studies seem to back up this conclusion. Studies have +shown that retaining memories can be improved by getting sufficient +sleep between the time of activity and a test. Neuroimaging shows that +the areas of the brain that are activated during sleep are the same as +those involved in learning a new task. Dreaming is perhaps useful in + + consolidating this new information. + +Also, some dreams can incorporate events that happened a few hours +earlier, just before sleep. But dreams mostly incorporate memories that +are a few days old. For example, experiments have shown that if you put +rose-colored glasses on a person, it takes a few days before the dreams +become rose-colored as well. + +BRAIN SCANS OF DREAMS" +"BRAIN SCANS OF DREAMS + +Brain scans are now unveiling some of the mystery of dreams. Normally +EEG scans show that the brain is emitting steady electromagnetic waves +while we are awake. However, as we gradually fall asleep, our EEG +signals begin to change frequency. When we finally dream, waves of +electrical energy emanate from the brain stem that surge upward, rising +into the cortical areas of the brain, especially the visual cortex. This +confirms that visual images are an important component of dreams. +Finally, we enter a dream state, and our brain waves are typified by + +rapid eye movements (REM). (Since some mammals also enter REM +sleep, we can infer that they might dream as well.)" +"While the visual areas of the brain are active, other areas involved +with smell, taste, and touch are largely shut down. Almost all the images +and sensations processed by the body are self-generated, originating +from the electromagnetic vibrations from our brain stem, not from +external stimuli. The body is largely isolated from the outside world. +Also, when we dream, we are more or less paralyzed. (Perhaps this +paralysis is to prevent us from physically acting out our dreams, which +could be disastrous. About 6 percent of people suffer from “sleep +paralysis” disorder, in which they wake up from a dream still paralyzed. +Often these individuals wake up frightened and believing that there are +creatures pinning down their chest, arms, and legs. There are paintings +from the Victorian era of women waking up with a terrifying goblin +sitting on their chest glaring down at them. Some psychologists believe +that sleep paralysis could explain the origin of the alien abduction +syndrome.)" +"The hippocampus is active when we dream, suggesting that dreams +draw upon our storehouse of memories. The amygdala and anterior +cingulate are also active, meaning that dreams can be highly emotional, +often involving fear. + +But more revealing are the areas of the brain that are shut down, +including the dorsolateral prefrontal cortex (which is the command + + center of the brain), the orbitofrontal cortex (which can act like a censor +or fact-checker), and the temporoparietal region (which processes +sensory motor signals and spatial awareness)." +"When the dorsolateral prefrontal cortex is shut down, we can’t count +on the rational, planning center of the brain. Instead, we drift aimlessly +in our dreams, with the visual center giving us images without rational +control. The orbitofrontal cortex, or the fact-checker, is also inactive. +Hence dreams are allowed to blissfully evolve without any constraints +from the laws of physics or common sense. And the temporoparietal +lobe, which helps coordinate our sense of where we are located using +signals from our eyes and inner ear, is also shut down, which may +explain our out-of-body experiences while we dream. + +As we have emphasized, human consciousness mainly represents the +brain constantly creating models of the outside world and simulating + +them into the future. If so, then dreams represent an alternate way in +which the future is simulated, one in which the laws of nature and social +interactions are temporarily suspended. + +HOW DO WE DREAM?" +"HOW DO WE DREAM? + +But that leaves open this question: What generates our dreams? One of +the world’s authorities on dreams is Dr. Allan Hobson, a psychiatrist at +Harvard Medical School. He has devoted decades of his life to unveiling +the secrets of dreams. He claims that dreams, especially REM sleep, can +be studied at the neurological level, and that dreams arise when the +brain tries to make sense of the largely random signals emanating from +the brain stem. + +When I interviewed him, he told me that after many decades of +cataloging dreams, he found five basic characteristics: + +1. Intense emotions—this is due to the activation of the amygdala, +causing emotions such as fear. + +2. Illogical content—dreams can rapidly shift from one scene to +another, in defiance of logic. + +3. Apparent sensory impressions—dreams give us false sensations that +are internally generated. + +4. Uncritical acceptance of dream events—we uncritically accept the +illogical nature of the dream." +"5. Difficulty in being remembered—dreams are soon forgotten, within +minutes of waking up. + +Dr. Hobson (with Dr. Robert McCarley) made history by proposing the +first serious challenge to Freud’s theory of dreams, called the “activation +synthesis theory.” In 1977, they proposed the idea that dreams originate +from random neural firings in the brain stem, which travel up to the +cortex, which then tries to make sense of these random signals. + +The key to dreams lies in nodes found in the brain stem, the oldest +part of the brain, which squirts out special chemicals, called adrenergics, +that keep us alert. As we go to sleep, the brain stem activates another + +system, the cholinergic, which emits chemicals that put us in a dream +state." +"system, the cholinergic, which emits chemicals that put us in a dream +state. + +As we dream, cholinergic neurons in the brain stem begin to fire, +setting off erratic pulses of electrical energy called PGO (pontine- +geniculate-occipital) waves. These waves travel up the brain stem into +the visual cortex, stimulating it to create dreams. Cells in the visual +cortex begin to resonate hundreds of times per second in an irregular +fashion, which is perhaps responsible for the sometimes incoherent +nature of dreams. + +This system also emits chemicals that decouple parts of the brain +involved with reason and logic. The lack of checks coming from the +prefrontal and orbitofrontal cortices, along with the brain becoming +extremely sensitive to stray thoughts, may account for the bizarre, +erratic nature of dreams." +"Studies have shown that it is possible to enter the cholinergic state +without sleep. Dr. Edgar Garcia-Rill of the University of Arkansas claims +that meditation, worrying, or being placed in an isolation tank can +induce this cholinergic state. Pilots and drivers facing the monotony of a +blank windshield for many hours may also enter this state. In his +research, he has found that schizophrenics have an unusually large +number of cholinergic neurons in their brain stem, which may explain +some of their hallucinations. + +To make his studies more efficient, Dr. Allan Hobson had his subjects +put on a special nightcap that can automatically record data during a +dream. One sensor connected to the nightcap registers the movements of +a person’s head (because head movements usually occur when dreams +end). Another sensor measures movements of the eyelids (because REM +sleep causes eyelids to move). When his subjects wake up, they +immediately record what they dreamed about, and the information from" +"the nightcap is fed into a computer. + +In this way, Dr. Hobson has accumulated a vast amount of information +about dreams. So what is the meaning of dreams? I asked him. He +dismisses what he calls the “mystique of fortune-cookie dream +interpretation.” He does not see any hidden message from the cosmos in +dreams. + +Instead, he believes that after the PGO waves surge from the brain +stem into the cortical areas, the cortex is trying to make sense of these + +erratic signals and winds up creating a narrative out of them: a dream. + +PHOTOGRAPHING A DREAM" +"erratic signals and winds up creating a narrative out of them: a dream. + +PHOTOGRAPHING A DREAM + +In the past, most scientists avoided the study of dreams, since they are so +subjective and have such a long historical association with mystics and +psychics. But with MRI scans, dreams are now revealing their secrets. In +fact, since the brain centers that control dreaming are nearly identical to +the ones that control vision, it is therefore possible to photograph a +dream. This pioneering work is being done in Kyoto, Japan, by scientists +at the ATR Computational and Neuroscience Laboratories." +"Subjects are first placed in an MRI machine and shown four hundred +black-and-white images, each consisting of a set of dots within a ten-by- +ten-pixel framework. One picture is flashed at a time, and the MRI +records how the brain responds to each collection of pixels. As with +other groups working in this field of BMI, the scientists eventually create +an encyclopedia of images, with each image of pixels corresponding to a +specific MRI pattern. Here the scientists are able to work backward, to +correctly reconstruct self-generated images from MRI brain scans taken +while the subject dreams. + +ATR chief scientist Yukiyasu Kamitani says, “This technology can also +be applied to senses other than vision. In the future, it may also be +possible to read feelings and complicated emotional states.” In fact, any +mental state of the brain might be imaged in this way, including dreams, +as long as a one-to-one map can be made between a certain mental state +and an MRI scan." +"The Kyoto scientists have concentrated on analyzing still photographs +generated by the mind. In Chapter 3, we encountered a similar approach +pioneered by Dr. Jack Gallant, in which the voxels from 3-D MRI scans +of the brain can be used to reconstruct the actual image seen by the eye +with the help of a complex formula. A similar process has allowed Dr. + + Gallant and his team to create a crude video of a dream. When I visited +the laboratory in Berkeley, I talked to a postdoctoral staff member, Dr. +Shinji Nishimoto, who allowed me to watch the video of one of his +dreams, one of the first ever done. I saw a series of faces flickering +across the computer screen, meaning that the subject (in this case Dr." +"Nishimoto himself) was dreaming of people, rather than animals or +objects. This was amazing. Unfortunately, the technology is not yet good +enough to see the precise facial features of the people appearing in his +dream, so the next step is to increase the number of pixels so that more +complex images can be identified. Another advance will be to reproduce +images in color rather than black and white. + +I then asked Dr. Nishimoto the crucial question: How do you know the +video is accurate? How do you know that the machine isn’t just making +things up? He was a bit sheepish when he replied that this was a weak +point in his research. Normally, you have only a few minutes after +waking up to record a dream. After that, most dreams are lost in the fog +of our consciousness, so it is not easy to verify the results." +"Dr. Gallant told me that this research on videotaping dreams was still +a work in progress, and that is why it’s not ready for publication. There +is still a ways to go before we can watch a videotape of last night’s +dream. + +LUCID DREAMS + +Scientists are also investigating a form of dreaming that was once +thought to be a myth: lucid dreaming, or dreaming while you are +conscious. This sounds like a contradiction in terms, but it has been +verified in brain scans. In lucid dreaming, dreamers are aware that they +are dreaming and can consciously control the direction of the dream. +Although science has only recently begun to experiment with lucid +dreaming, there are references to this phenomenon dating back +centuries. In Buddhism, for example, there are books that refer to lucid +dreamers and how to train yourself to become one. Over the centuries, +several people in Europe have written detailed accounts of their lucid +dreams." +"Brain scans of lucid dreamers show that this phenomenon is real; +during REM sleep, their dorsolateral prefrontal cortex, which is usually +dormant when a normal person dreams, is active, indicating that the +person is partially conscious while dreaming. In fact, the more lucid the +dream, the more active the dorsolateral prefrontal cortex. Since the +dorsolateral prefrontal cortex represents the conscious part of the brain, + + the dreamer must be aware while he or she is dreaming." +"the dreamer must be aware while he or she is dreaming. + +Dr. Hobson told me that anyone can learn to do lucid dreaming by +practicing certain techniques. In particular, people who do lucid +dreaming should keep a notebook of dreams. Before going to sleep, they +should remind themselves that they will “wake up” in the middle of the +dream and realize that they are moving in a dream world. It is important +to have this frame of mind before hitting the pillow. Since the body is +largely paralyzed during REM sleep, it is difficult for the dreaming +person to send a signal to the outside world that he has entered a dream, +but Dr. Stephen LaBerge at Stanford University has studied lucid +dreamers (including himself) who can signal the outside world while +dreaming." +"In 2011, for the first time, scientists used MRI and EEG sensors to +measure dream content and even make contact with a dreaming person. +At the Max Planck Institute in Munich and Leipzig, scientists enlisted the +help of lucid dreamers, who were fitted with EEG sensors on their heads +to help the scientists determine the moment they entered REM sleep; +they were then placed in an MRI machine. Before falling asleep, the +dreamers agreed to initiate a set of eye movements and breathing +patterns when dreaming, like a Morse code. They were told that once +they started dreaming, they should clench their right fist and then their +left one for ten seconds. That was the signal that they were dreaming." +"The scientists found that, once the subjects entered their dream state, +the sensorimotor cortex of the brain (responsible for controlling motor +actions like clenching your fists) was activated. The MRI scans could +pick up that the fists were being clenched and which fist was being +clenched first. Then, using another sensor (a near-infrared spectrometer) +they were able to confirm that there was increased brain activity in the +region that controls the planning of movements. + +“Our dreams are therefore not a ‘sleep cinema’ in which we merely +observe an event passively, but involve activity in the regions of the +brain that are relevant to the dream content,” says Michael Czisch, a +group leader at the Max Planck Institute. + +ENTERING A DREAM + +If we can communicate with a dreaming person, then is it also possible +to alter someone’s dream from the outside? Quite possibly. + +First, as we have seen, scientists have already made the initial steps in" +"First, as we have seen, scientists have already made the initial steps in + + videotaping a person’s dream, and in the coming years, it should be +possible to create much more accurate pictures and videos of dreams. +Since scientists have already been able to establish a communication link +between the real world and the lucid dreamer in the fantasy world, then, +in principle, scientists should be able to deliberately alter the course of a +dream. Let’s say that scientists are viewing the video of a dream using an +MRI machine as the dream unfolds in real time. As the person wanders +around the dreamscape, the scientists can tell where he is going and give +directions for him to move in different ways. + +So in the near future, it might be possible to watch a video of a +person’s dream and actually influence its general direction. But in the +movie Inception, Leonardo DiCaprio goes much further. He is able not +only to watch another person’s dream, but also to enter it. Is this +possible?" +"We saw earlier that we are paralyzed when we dream so that we don’t +carry out our dream fantasies, which might be disastrous. However, +when people are sleepwalking, they often have their eyes open (although +their eyes look glazed over). So sleepwalkers live in a hybrid world, part +real and part dreamlike. There are many documented instances of people +walking around their homes, driving cars, cutting wood, and even +committing homicides while in this dream state, where reality and the +fantasy world are mixed. Hence it is possible that physical images that +the eye actually sees can freely interact with the fictitious images that +the brain is concocting during a dream." +"The way to enter someone’s dream, then, might be to have the subject +wear contact lenses that can project images directly onto their retinas. +Already, prototypes of Internet contact lenses are being developed at the +University of Washington in Seattle. So if the observer wanted to enter +the subject’s dream, first he would sit in a studio and have a video +camera film him. His image could then be projected onto the contact +lenses of the dreamer, creating a composite image (the image of the +observer superimposed upon the imaginary image the brain is +manufacturing). + +The observer could actually see this dream world as he wanders + +around the dream, since he, too, would be wearing Internet contact +lenses. The MRI image of the subject’s dream, after it has been +deciphered by computer, would be sent directly into the observer’s +contact lenses." +"Furthermore, you could actually change the direction of the dream +you have entered. As you walk around in the empty studio, you would +see the dream unfold in your contact lens, so you could start to interact + + with the objects and people appearing in the dream. This would be quite +an experience, since the background would change without warning, +images would appear and disappear without reason, and the laws of +physics would be suspended. Anything goes." +"Further into the future, it might even be possible to enter another +person’s dream by directly connecting two sleeping brains. Each brain +would have to be connected to MRI scanners that were connected to a +central computer, which would merge the two dreams into a single one. +The computer would first decipher each person’s MRI scans into a video +image. Then the dream of one person would be sent into the sensory +areas of the other person’s brain, so that the other dreamer’s dream +would merge with the first dreamer’s dream. However, the technology of +videotaping and interpreting dreams would have to become much more +advanced before this could become a possibility." +"But this raises another question: If it’s possible to alter the course of +someone’s dream, is it possible to control not only that person’s dream +but that person’s mind as well? During the Cold War, this became a +serious issue as both the Soviet Union and the United States played a +deadly game, trying to use psychological techniques to control other +people’s wills. + +Minds are simply what brains do. + +—MARVIN MINSKY + +8 CAN THE MIND BE CONTROLLED?" +"Minds are simply what brains do. + +—MARVIN MINSKY + +8 CAN THE MIND BE CONTROLLED? + +A raging bull is released into an empty arena in Cordoba, Spain. For +generations, this ferocious beast has been carefully bred to maximize its +killer instinct. Then a Yale professor calmly enters the same arena. +Rather than donning a tweed jacket, he is dressed like a dashing +matador, wearing a bright golden jacket and waving a red cape defiantly +in front of the bull, egging him on. Instead of running away in terror, the +professor looks calm, confident, and even detached. To a bystander, it +appears as if the professor has gone mad and wants to commit suicide." +"Enraged, the bull locks onto the professor. Suddenly the bull charges, +aiming his deadly horns at him. The professor does not run away in fear. +Instead, he holds a small box in his hand. Then, in front of the cameras, +he presses a button on the box, and the bull stops dead in his tracks. The +professor is so confident of himself that he has risked his life to prove a +point, that he has mastered the art of controlling the mind of a mad bull. + + The Yale professor is Dr. Jose Delgado, who was years ahead of his +time. He pioneered a series of remarkable but unsettling animal +experiments in the 1960s, in which he put electrodes into their brains +with the aim of trying to control their movement. To stop the bull, he +inserted electrodes into the striatum of the basal ganglia at the base of +the brain, which is involved with motor coordination." +"He also did a series of other experiments on monkeys to see if he could +rearrange their social hierarchy with the push of a button. After +implanting electrodes into the caudate nucleus (a region associated with +motor control) of the alpha male within the group, Delgado could reduce +the aggressive tendencies of the leader on command. Without threats of +retaliation, the delta males began to assert themselves, taking over the +territory and privileges normally reserved for the alpha male. The alpha +male, meanwhile, appeared to have lost interest in defending his +territory. + +Then Dr. Delgado pressed another button, and the alpha male + +instantly sprung back to normal, resuming his aggressive behavior and +reestablishing his power as the king of the hill. The delta males +scrambled in fear. + +Dr. Delgado was the first person in history to show that it was possible +to control the minds of animals in this way. The professor became the +puppet master, pulling the strings of living puppets." +"As expected, the scientific community looked at Dr. Delgado’s work +with unease. To make matters worse, he wrote a book in 1969 with the +provocative title Physical Control of the Mind: Toward a Psychocivilized +Society. It raised an unsettling question: If scientists like Dr. Delgado are +pulling the strings, then who controls the puppet master?" +"Dr. Delgado’s work puts into sharp focus the enormous promise and +perils of this technology. In the hands of an unscrupulous dictator, this +technology might be used to deceive and control his unfortunate +subjects. But it can also be used to free millions of people who are +trapped in mental illness, hounded by their hallucinations, or crushed by +their anxieties. (Years later, Dr. Delgado was asked by a journalist why +he initiated these controversial experiments. He said that he wanted to +correct the horrendous abuses being suffered by the mentally ill. They +often underwent radical lobotomies, in which the prefrontal cortex was +scrambled by a knife resembling an ice pick, which was hammered into +the brain above the eye socket. The results were often tragic, and some +of the horrors were exposed in Ken Kesey’s novel One Flew Over the +Cuckoo’s Nest, which was made into a movie with Jack Nicholson. Some" +"patients became calm and relaxed, but many others became zombies: +lethargic, indifferent to pain and feelings, and emotionally vacuous. The +practice was so widespread that in 1949, Antonio Moniz won the Nobel +Prize for perfecting the lobotomy. Ironically, in 1950, the Soviet Union +banned this technology, stating that “it was contrary to the principles of +humanity.” Lobotomies, the Soviet Union charged, turned “an insane +person into an idiot.” In total, it is estimated that forty thousand +lobotomies were performed in the United States alone over two +decades.) + +MIND CONTROL AND THE COLD WAR + +Another reason for the chilly reception of Dr. Delgado’s work was the +political climate of the time. It was the height of the Cold War, with +painful memories of captured U.S. soldiers being paraded in front of +cameras during the Korean War. With blank stares, they would admit +they were on secret spy missions, confess to horrific war crimes, and +denounce U.S. imperialism." +"To make sense of this, the press used the term “brainwashing,” the +idea that the communists had developed secret drugs and techniques to +turn U.S. soldiers into pliable zombies. In this charged political climate, +Frank Sinatra starred in the 1962 Cold War thriller The Manchurian +Candidate, in which he tries to expose a secret communist “sleeper” +agent whose mission is to assassinate the president of the United States. +But there is a twist. The assassin is actually a trusted U.S. war hero, +someone who was captured and then brainwashed by the communists. +Coming from a well-connected family, the agent seems above suspicion +and is almost impossible to stop. The Manchurian Candidate mirrored the +anxieties of many Americans at that time." +"Many of these fears were also stoked by Aldous Huxley’s prophetic +1931 novel Brave New World. In this dystopia, there are large test-tube- +baby factories that produce clones. By selectively depriving oxygen from +these fetuses, it is possible to produce children of different levels of brain +damage. At the top are the alphas, who suffer no brain damage and are +bred to rule society. At the bottom are the epsilons, who suffer +significant brain damage and are used as disposable, obedient workers. +In between are additional levels made up of other workers and the +bureaucracy. The elite then control society by flooding it with mind- +altering drugs, free love, and constant brainwashing. In this way, peace, +tranquility, and harmony are maintained, but the novel asked a +disturbing question that resonates even today: How much of our freedom +and basic humanity do we want to sacrifice in the name of peace and +social order? + + CIA MIND-CONTROL EXPERIMENTS" +"CIA MIND-CONTROL EXPERIMENTS + +The Cold War hysteria eventually reached the highest levels of the CIA. +Convinced that the Soviets were far ahead in the science of brainwashing + +and unorthodox scientific methods, the CIA embarked upon a variety of +classified projects, such as MKULTRA, which began in 1953, to explore +bizarre, fringe ideas. (In 1973, as the Watergate scandal spread panic +throughout the government, CIA director Richard Helms canceled +MKULTRA and hurriedly ordered all documents pertaining to the project +destroyed. However, a cache of twenty thousand documents somehow +survived the purge and were declassified in 1977 under the Freedom of +Information Act, revealing the full scope of this massive effort.)" +"It is now known that, from 1953 to 1973, MULTRA funded 80 +institutions, including 44 universities and colleges, and scores of +hospitals, pharmaceutical companies, and prisons, often experimenting +on unsuspecting people without their permission, in 150 secret +operations. At one point, fully 6 percent of the entire CIA budget went +into MKULTRA. + +Some of these mind-control projects included: + +• developing a “truth serum” so prisoners would spill their secrets + +• erasing memories via a U.S. Navy project called “Subproject 54” + +• using hypnosis and a wide variety of drugs, especially LSD, to +control behavior + +• investigating the use of mind-control drugs against foreign leaders, +e.g., Fidel Castro + +• perfecting a variety of interrogation methods against prisoners + +• developing a knockout drug that was fast working and left no trace + +• altering people’s personality via drugs to make them more pliable" +"• altering people’s personality via drugs to make them more pliable + +Although some scientists questioned the validity of these studies, +others went along willingly. People from a wide range of disciplines +were recruited, including psychics, physicists, and computer scientists, to +investigate a variety of unorthodox projects: experimenting with mind- +altering drugs such as LSD, asking psychics to locate the position of +Soviet submarines patrolling the deep oceans, etc. In one sad incident, a + + U.S. Army scientist was secretly given LSD. According to some reports, +he became so violently disoriented that he committed suicide by +jumping out a window." +"Most of these experiments were justified on the grounds that the +Soviets were already ahead of us in terms of mind control. The U.S. +Senate was briefed in another secret report that the Soviets were +experimenting with beaming microwave radiation directly into the +brains of test subjects. Rather than denouncing the act, the United States +saw “great potential for development into a system for disorienting or +disrupting the behavior pattern of military or diplomatic personnel.” The +U.S. Army even claimed that it might be able to beam entire words and +speeches into the minds of the enemy: “One decoy and deception +concept ... is to remotely create noise in the heads of personnel by +exposing them to low power, pulsed microwaves.... By proper choice of +pulse characteristics, intelligible speech may be created.... Thus, it may +be possible to ‘talk’ to selected adversaries in a fashion that would be +most disturbing to them,” the report said." +"Unfortunately, none of these experiments was peer-reviewed, so +millions of taxpayer dollars were spent on projects like this one, which +most likely violated the laws of physics, since the human brain cannot +receive microwave radiation and, more important, does not have the +ability to decode microwave messages. Dr. Steve Rose, a biologist at the +Open University, has called this far-fetched scheme a “neuro-scientific +impossibility.” + +But for all the millions of dollars spent on these “black projects,” +apparently not a single piece of reliable science emerged. The use of +mind-altering drugs did, in fact, create disorientation and even panic +among the subjects who were tested, but the Pentagon failed to +accomplish the key goal: control of the conscious mind of another +person." +"Also, according to psychologist Robert Jay Lifton, brainwashing by the +communists had little long-term effect. Most of the American troops who +denounced the United States during the Korean War reverted back to +their normal personalities soon after being released. In addition, studies +done on people who have been brainwashed by certain cults also show +that they revert back to their normal personality after leaving the cult. +So it seems that, in the long run, one’s basic personality is not affected +by brainwashing. + +Of course, the military was not the first to experiment with mind +control. In ancient times, sorcerers and seers would claim that giving + + magic potions to captured soldiers would make them talk or turn against +their leaders. One of the earliest of these mind-control methods was +hypnotism. + +YOU ARE GETTING SLEEPY...." +"YOU ARE GETTING SLEEPY.... + +As a child, I remember seeing TV specials devoted to hypnosis. In one +show, a person was placed in a hypnotic trance and told that when he +woke up, he would be a chicken. The audience gasped as he began to +cluck and flap his arms around the stage. As dramatic as this +demonstration was, it’s simply an example of “stage hypnosis.” Books +written by professional magicians and showmen explain that they use +shills planted in the audience, the power of suggestion, and even the +willingness of the victim to play along with the ruse. + +I once hosted a BBC/Discovery TV documentary called Time, and the +subject of long-lost memories came up. Is it possible to evoke such +distant memories through hypnosis? And if it is, can you then impose +your will on another? To test some of these ideas, I had myself +hypnotized for TV." +"BBC hired a skilled professional hypnotist to begin the process. I was +asked to lie down on a bed in a quiet, darkened room. The hypnotist +spoke to me in slow, gentle tones, gradually making me relax. After a +while, he asked me to think back into the past, to perhaps a certain place +or incident that stood out even after all these years. And then he asked +me to reenter that place, reexperiencing its sights, sounds, and smells. +Remarkably, I did begin to see places and people’s faces that I had +forgotten about decades ago. It was like watching a blurred movie that +was slowly coming into focus. But then the recollections stopped. At a +certain point, I could not recapture any more memories. There was +clearly a limit to what hypnosis could do." +"EEG and MRI scans show that during hypnosis the subject has minimal +sensory stimulation in the sensory cortices from the outside. In this way, +hypnosis can allow one to access some memories that are buried, but it +certainly cannot change one’s personality, goals, or wishes. A secret +1966 Pentagon document corroborates this, explaining that hypnotism +cannot be trusted as a military weapon. “It is probably significant that in + +the long history of hypnosis, where the potential application to +intelligence has always been known, there are no reliable accounts of its +effective use by an intelligence service,” it read." +"It should also be noted that brain scans show that hypnotism is not a +new state of consciousness, like dreaming and REM sleep. If we define +human consciousness as the process of continually building models of +the outside world and then simulating how they evolve into the future to +carry out a goal, we see that hypnosis cannot alter this basic process. +Hypnosis can accentuate certain aspects of consciousness and help +retrieve certain memories, but it cannot make you squawk like a chicken +without your permission. + +MIND-ALTERING DRUGS AND TRUTH SERUMS + +One of the goals of MKULTRA was the creation of a truth serum so that +spies and prisoners would reveal their secrets. Although MKULTRA was +canceled in 1973, U.S. Army and CIA interrogation manuals declassified +by the Pentagon in 1996 still recommended the use of truth serums +(although the U.S. Supreme Court ruled that confessions obtained in this +way were “unconstitutionally coerced” and hence inadmissible in court)." +"Anyone who watches Hollywood movies knows that sodium pentathol +is the truth serum of choice used by spies (as in the movies True Lies +with Arnold Schwarzenegger and Meet the Fockers with Robert De Niro). +Sodium pentathol is part of a larger class of barbiturates, sedatives, and +hypnotics that can evade the blood-brain barrier, which prevents most +harmful chemicals in the bloodstream from entering the brain." +"Not surprisingly, most mind-altering drugs, such as alcohol, affect us +powerfully because they can evade this barrier. Sodium pentathol +depresses activity in the prefrontal cortex, so that a person becomes +more relaxed, talkative, and uninhibited. However, this does not mean +that they tell the truth. On the contrary, people under the influence of +sodium pentathol, like those who have imbibed a few too many, are +fully capable of lying. The “secrets” that come spilling out of the mouth +of someone under this drug may be total fabrications, so even the CIA +eventually gave up on drugs like this. + +But this still leaves open the possibility that, one day, a wonder drug" +"But this still leaves open the possibility that, one day, a wonder drug + +might be found that could alter our basic consciousness. This drug would +work by changing the synapses between our nerve fibers by targeting +neurotransmitters that operate in this area, such as dopamine, serotonin, +or acetylcholine. If we think of the synapses as a series of tollbooths +along a superhighway, then certain drugs (such as stimulants like +cocaine) can open the tollbooth and let messages pass by unimpeded. +The sudden rush that drug addicts feel is caused when these tollbooths +are opened all at once, causing an avalanche of signals to flood by. But + + when all the synapses have fired in unison, they cannot fire again until +hours later. It’s as if the tolls have closed, and this causes the sudden +depression one feels after the rush. The body’s desire to reexperience the +sudden rush then causes addiction. + +HOW DRUGS ALTER THE MIND" +"HOW DRUGS ALTER THE MIND + +Although the biochemical basis for mind-altering drugs was not known +when the CIA first conducted its experiments on unsuspecting subjects, +since then the molecular basis of drug addiction has been studied in +detail. Studies in animals demonstrate how powerful drug addiction is: +rats, mice, and primates will, given the chance, take drugs like cocaine, +heroin, and amphetamines until they drop from exhaustion or die from +it." +"To see how widespread this problem has become, consider that by +2007, thirteen million Americans aged twelve or over (or 5 percent of +the entire teen and adult population of the United States) had tried or +become addicted to methamphetamines. Drug addiction not only +destroys entire lives, it also systematically destroys the brain. MRI scans +of the brains of meth addicts show an 11 percent reduction in the size of +the limbic system, which processes emotions, and an 8 percent loss of +tissue in the hippocampus, which is the gateway for memory. MRI scans +show that the damage in some ways is comparable to that found in +Alzheimer’s patients. But no matter how much meth destroys the brain, +addicts crave it because its high is up to twelve times the rush caused by +eating a delicious meal or even having sex. + +Basically, the “high” of drug addiction is due to the drug’s hijacking of +the brain’s own pleasure/reward system located in the limbic system." +"This pleasure/reward circuit is very primitive, dating back millions of +years in evolutionary history, but it is still extremely important for +human survival because it rewards beneficial behavior and punishes +harmful acts. Once this circuit is taken over by drugs, however, the +result can be widespread havoc. These drugs first penetrate the blood- +brain barrier and then cause the overproduction of neurotransmitters +like dopamine, which then floods the nucleus accumbens, a tiny pleasure +center located deep in the brain near the amygdala. The dopamine, in +turn, is produced by certain brain cells in the ventral tegmental area, +called VTA cells. + +All drugs basically work the same way: by crippling the VTA-nucleus +accumbens circuit, which controls the flow of dopamine and other +neurotransmitters to the pleasure center. Drugs differ only in the way in" +"which this process takes place. There are at least three main drugs that +stimulate the pleasure center of the brain: dopamine, serotonin, and +noradrenaline; all of them give feelings of pleasure, euphoria, and false +confidence, and also produce a burst of energy. + +Cocaine and other stimulants, for example, work in two ways. First, +they directly stimulate the VTA cells to produce more dopamine, hence +causing excess dopamine to flood into the nucleus accumbens. Second, +they prevent the VTA cells from going back to their “off” position, thus +keeping them continually producing dopamine. They also impede the +uptake of serotonin and noradrenaline. The simultaneous flooding of +neural circuits from all three of these neurotransmitters, then, creates +the tremendous high associated with cocaine. + +Heroin and other opiates, by contrast, work by neutralizing the cells in +the VTA that can reduce the production of dopamine, thus causing the +VTA to overproduce dopamine." +"Drugs like LSD operate by stimulating the production of serotonin, +inducing a feeling of well-being, purpose, and affection. But they also +activate areas of the temporal lobe involved in creating hallucinations. +(Only fifty micrograms of LSD can cause hallucinations. LSD binds so +tightly, in fact, that further increasing the dosage has no effect.) + +Over time, the CIA came to realize that mind-altering drugs were not +the magic bullet they were looking for. The hallucinations and +addictions that accompany these drugs made them too unstable and +unpredictable, and they could cause more trouble than they were worth + +in delicate political situations." +"(It should be pointed out that just in the last few years, MRI brain +scans of drug addicts have indicated a novel way to possibly cure or +treat some forms of addiction. By accident, it was noticed that stroke +victims who have damage to the insula [located deep in the brain, +between the prefrontal cortex and the temporal cortex] have a +significantly easier time quitting smoking than the average smoker. This +result has also been verified among drug abusers using cocaine, alcohol, +opiates, and nicotine. If this result holds up, it might mean that one may +be able to dampen the activity of the insula using electrodes or magnetic +stimulators and hence treat addiction. “This is the first time we’ve shown +anything like this, that damage to a specific brain area could remove the +problem of addiction entirely. It’s mind-boggling,” says Dr. Nora +Volkow, director of the National Institute on Drug Abuse. At present, no +one knows how this works, because the insula is involved in a" +"one knows how this works, because the insula is involved in a +bewildering variety of brain functions, including perception, motor +control, and self-awareness. But if this result bears out, it could change" +"the entire landscape of addiction studies.) + +PROBING THE BRAIN WITH OPTOGENETICS + +These mind-control experiments were done mainly in an era when the +brain was largely a mystery, with hit-or-miss methods that often failed. +However, because of the explosion in devices that can probe the brain, +new opportunities have arisen that will both help us understand the +brain as well as possibly teach us how to control it. + +Optogenetics, as we have seen, is one of the fastest-developing fields +in science today. The basic goal is to identify precisely which neural +pathway corresponds to which mode of behavior. Optogenetics starts +with a gene called opsin, which is quite unusual because it is sensitive to +light. (It is believed that the appearance of this gene hundreds of +millions of years ago was responsible for creating the first eye. In this +theory, a simple patch of skin sensitive to light due to opsin evolved into +the retina of the eye.)" +"When the opsin gene is inserted into a neuron and exposed to light, +the neuron will fire on command. By flipping a switch, one can instantly + +recognize the neural pathway for certain behaviors because the proteins +manufactured by opsin conduct electricity and will fire. + +The hard part, though, is to insert this gene into a single neuron. To +do this, one uses a technique borrowed from genetic engineering. The +opsin gene is inserted into a harmless virus (which has had its bad genes +removed), and, using precision tools, it is then possible to apply this +virus to a single neuron. The virus then infects the neuron by inserting +its genes into the genes of the neuron. Then, when a light beam is +flashed onto neural tissue, the neuron is turned on. In this way, one can +establish the precise pathway that certain messages take." +"Not only does optogenetics identify certain pathways by shining a +light beam on them, it also enables scientists to control behavior. +Already this method has been a proven success. It was long suspected +that a simple neural circuit must be responsible for fruit flies escaping +and flying away. Using this method, it was possible to finally identify the +precise pathway behind the quick getaway. By simply shining a beam +onto these fruit flies, they bolt on demand. + +Scientists are also now able to make worms stop wiggling by flashing +light, and in 2011 yet another breakthrough was made. Scientists at +Stanford were able to insert the opsin gene into a precise region of the + + amygdala of mice. These mice, which were specially bred to be timid, +cowered in their cage. But when a beam of light was flashed into their +brains, the mice suddenly lost their timidity and began to explore their +cage." +"The implications are enormous. While fruit flies may have simple +reflex mechanisms involving a handful of neurons, mice have complete +limbic systems with counterparts in the human brain. Although many +experiments that work with mice do not translate to human beings, this +still holds out the possibility that scientists may one day find the precise +neural pathways for certain mental illnesses, and then be able to treat +them without any side effects. As Dr. Edward Boyden of MIT says, “If +you want to turn off a brain circuit and the alternative is surgical +removal of a brain region, optical fiber implants might seem preferable.” + +One practical application is in treating Parkinson’s disease. As we have +seen, it can be treated by deep brain stimulation, but because the +positioning of electrodes in the brain lacks precision, there is always the +danger of strokes, bleeding, infections, etc. Deep brain stimulation can" +"also cause side effects such as dizziness and muscle contractions, because +the electrodes can accidentally stimulate the wrong neurons. +Optogenetics may improve deep brain stimulation by identifying the +precise neural pathways that are misfiring, at the level of individual +neurons. + +Victims of paralysis might also benefit from this new technology. As +we saw in Chapter 4, some paralyzed individuals have been hooked up +to a computer in order to control a mechanical arm, but because they +have no sense of touch, they often wind up dropping or crushing the +object they wish to grab. “By feeding information from sensors on the +prosthetic fingertips directly back to the brain using optogenetics, one +could in principle provide a high-fidelity sense of touch,” says Dr. +Krishna Shenoy of Stanford." +"Optogenetics will also help clarify which neural pathways are involved +with human behavior. In fact, plans have already been drawn up to +experiment with this technique on human brains, especially with regard +to mental illness. There will be hurdles, of course. First, the technique +requires opening up the skull, and if the neurons that one wishes to +study are located deep inside the brain, the procedure will be even more +invasive. Lastly, one has to insert tiny wires into the brain that can shine +a light on this modified neuron so that it triggers the desired behavior. + +Once these neural pathways have been deciphered, you can also +stimulate them, making animals perform strange behaviors (for example, +mice will run around in circles). Although scientists are just beginning to" +"trace the neural pathways governing simple animal behaviors, in the +future they should have an encyclopedia of such behaviors, including +those of humans. In the wrong hands, however, optogenetics could +potentially be used to control human behavior. + +In the main, the benefits of optogenetics greatly outweigh its +drawbacks. It can literally reveal the pathways of the brain in order to +treat mental illness and other diseases. This may then give scientists the +tools by which to repair the damage, perhaps curing diseases once +thought to be incurable. In the near future, then, the benefits are all +positive. But further in the future, once the pathways of human +behaviors are also understood, optogenetics could also be used to control +or at least modify human behavior as well. + +MIND CONTROL AND THE FUTURE" +"MIND CONTROL AND THE FUTURE + +In summary, the use of drugs and hypnotism by the CIA was a flop. +These techniques were too unstable and unpredictable to be of any use +to the military. They can be used to induce hallucinations and +dependency, but they have failed to cleanly erase memories, make +people more pliant, or force people to perform acts against their will. +Governments will keep trying, but the goal is elusive. So far, drugs are +simply too blunt an instrument to allow you to control someone’s +behavior. + +But this is also a cautionary tale. Carl Sagan mentions one nightmare +scenario that might actually work. He envisions a dictator taking +children and putting electrodes into their “pain” and “pleasure” centers. +These electrodes are then connected wirelessly to computers, so that the +dictator can control his subjects with the push of a button." +"Another nightmare might involve probes placed in the brain that +could override our wishes and seize control of our muscles, forcing us to +perform tasks we don’t want to do. The work of Dr. Delgado was crude, +but it showed that bursts of electricity applied to motor areas of the +brain can overrule our conscious thoughts, so that our muscles are no +longer under our control. He was able to identify only a few behaviors in +animals that could be controlled with electric probes. In the future, it +may be possible to find a wide variety of behaviors that can be +controlled electronically with a switch." +"If you are the person being controlled, it would be an unpleasant +experience. Although you may think you are master of your own body, +your muscles would actually fire without your permission, so you would +do things against your will. The electric impulse being fed into your +brain could be larger than the impulses you consciously send into your +muscles, so that it would appear as if someone had hijacked your body. + + Your own body would become a foreign object. + +In principle, some version of this nightmare might be possible in the +future. But there are several factors that may prevent this as well. First, +this is still an infant technology and it is not known how it will be +applied to human behavior, so there is still plenty of time to monitor its +development and perhaps create safeguards to see that it is not misused. +Second, a dictator might simply decide that propaganda and coercion," +"the usual methods of controlling a population, are cheaper and more +effective than putting electrodes into the brains of millions of children, +which would be costly and invasive. And third, in democratic societies, a +vigorous public debate would probably emerge concerning the promise +and limitations of this powerful technology. Laws would have to be +passed to prevent the abuse of these methods without impairing their +ability to reduce human suffering. Soon science will give us unparalleled +insight into the detailed neural pathways of the brain. A fine line has to +be drawn between technologies that can benefit society and technologies +that can control it. And the key to passing these laws is an educated, +informed public." +"But the real impact of this technology, I believe, will be to liberate the +mind, not enslave it. These technologies can give hope to those who are +trapped in mental illness. Although there is as yet no permanent cure for +mental illness, these new technologies have given us deep insight into +how such disorders form and how they progress. One day, through +genetics, drugs, and a combination of high-tech methods, we will find a +way to manage and eventually cure these ancient diseases. + +One of the recent attempts to exploit this new knowledge of the brain +is to understand historical personalities. Perhaps the insights from +modern science can help explain the mental states of those in the past. + +And one of the most mystifying figures being analyzed today is Joan +of Arc. + +Lovers and madmen have such seething brains.. +The lunatic, the lover, and the poet +Are of imagination all compact. + +-WILLIAM SHAKESPEARE, A MIDSUMMER NIGHT S DREAM + +9 ALTERED STATES OF CONSCIOUSNESS" +"-WILLIAM SHAKESPEARE, A MIDSUMMER NIGHT S DREAM + +9 ALTERED STATES OF CONSCIOUSNESS + + She was just an illiterate peasant girl who claimed to hear voices +directly from God. But Joan of Arc would rise from obscurity to lead a +demoralized army to victories that would change the course of nations, +making her one of the most fascinating, compelling, and tragic figures in +history." +"During the chaos of the Hundred Years’ War, when northern France +was decimated by English troops and the French monarchy was in +retreat, a young girl from Orleans claimed to have divine instructions to +lead the French army to victory. With nothing to lose, Charles VII +allowed her to command some of his troops. To everyone’s shock and +wonder, she scored a series of triumphs over the English. News rapidly +spread about this remarkable young girl. With each victory, her +reputation began to grow, until she became a folk heroine, rallying the +French around her. French troops, once on the verge of total collapse, +scored decisive victories that paved the way for the coronation of the +new king." +"However, she was betrayed and captured by the English. They realized +what a threat she posed to them, since she was a potent symbol for the +French and claimed guidance directly from God Himself, so they +subjected her to a show trial. After an elaborate interrogation, she was +found guilty of heresy and burned at the stake at the age of nineteen in +1431. + +In the centuries that followed, hundreds of attempts have been made +to understand this remarkable teenager. Was she a prophet, a saint, or a +madwoman? More recently, scientists have tried to use modern +psychiatry and neuroscience to explain the lives of historical figures such +as Joan of Arc. + +Few question her sincerity about claims of divine inspiration. But +many scientists have written that she might have suffered from +schizophrenia, since she heard voices. Others have disputed this fact," +"since the surviving records of her trial reveal a person of rational +thought and speech. The English laid several theological traps for her. +They asked, for example, if she was in God’s grace. If she answered yes, +then she would be a heretic, since no one can know for certain if they +are in God’s grace. If she said no, then she was confessing her guilt, and +that she was a fraud. Either way, she would lose. + +In a response that stunned the audience, she answered, “If I am not, +may God put me there; and if I am, may God so keep me.” The court +notary, in the records, wrote, “Those who were interrogating her were + + stupefied.” + +In fact, the transcripts of her interrogation are so remarkable that +George Bernard Shaw put literal translations of the court record in his +play Saint Joan." +"More recently, another theory has emerged about this exceptional +woman: perhaps she actually suffered from temporal lobe epilepsy. +People who have this condition sometimes experience seizures, but some +of them also experience a curious side effect that may shed some light on +the structure of human beliefs. These patients suffer from +“hyperreligiosity,” and can’t help thinking that there is a spirit or +presence behind everything. Random events are never random, but have +some deep religious significance. Some psychologists have speculated +that a number of history’s prophets suffered from these temporal lobe +epileptic lesions, since they were convinced they talked to God. The +neuroscientist Dr. David Eagleman says, “Some fraction of history’s +prophets, martyrs, and leaders appear to have had temporal lobe +epilepsy. Consider Joan of Arc, the sixteen-year-old girl who managed to +turn the tide of the Hundred Years’ War because she believed (and" +"turn the tide of the Hundred Years’ War because she believed (and +convinced the French soldiers) that she was hearing voices from Saint +Michael the archangel, Saint Catherine of Alexandria, Saint Margaret, +and Saint Gabriel.”" +"This curious effect was noticed as far back as 1892, when textbooks on +mental illness noted a link between “religious emotionalism” and +epilepsy. It was first clinically described in 1975 by neurologist Norman +Geschwind of Boston Veterans Administration Hospital. He noticed that +epileptics who had electrical misfirings in their left temporal lobes often +had religious experiences, and he speculated that the electrical storm in +the brain somehow was the cause of these religious obsessions. + +Dr. V. S. Ramachandran estimates that 30 to 40 percent of all the +temporal lobe epileptics whom he has seen suffer from hyperreligiosity. +He notes, “Sometimes it’s a personal God, sometimes it’s a more diffuse +feeling of being one with the cosmos. Everything seems suffused with +meaning. The patient will say, ‘Finally, I see what it is all really about, +Doctor. I really understand God. I understand my place in the universe— +the cosmic scheme.’ ”" +"He also notes that many of these individuals are extremely adamant +and convincing in their beliefs. He says, “I sometimes wonder whether +such patients who have temporal lobe epilepsy have access to another +dimension of reality, a wormhole of sorts into a parallel universe. But I +usually don’t say this to my colleagues, lest they doubt my sanity.” He +has experimented on patients with temporal lobe epilepsy, and +confirmed that these individuals had a strong emotional reaction to the + + word “God” but not to neutral words. This means that the link between +hyperreligiosity and temporal lobe epilepsy is real, not just anecdotal. + +Psychologist Michael Persinger asserts that a certain type of +transcranial electrical stimulation (called transcranial magnetic +simulation, or TMS) can deliberately induce the effect of these epileptic +lesions. If this is so, is it possible that magnetic fields can be used to alter +one’s religious beliefs?" +"In Dr. Persinger’s studies, the subject places a helmet on his head +(dubbed the “God helmet”), which contains a device that can send +magnetism into particular parts of the brain. Afterward, when the +subject is interviewed, he will often claim that he was in the presence of +some great spirit. David Biello, writing in Scientific American, says, +“During the three-minute bursts of stimulation, the affected subjects +translated this perception of the divine into their own cultural and +religious language—terming it God, Buddha, a benevolent presence, or +the wonder of the universe.” Since this effect is reproducible on demand, +it indicates that perhaps the brain is hardwired in some way to respond +to religious feelings." +"Some scientists have gone further and have speculated that there is a +“God gene” that predisposes the brain to be religious. Since most +societies have created a religion of some sort, it seems plausible that our +ability to respond to religious feelings might be genetically programmed +into our genome. (Meanwhile, some evolutionary theorists have tried to + +explain these facts by claiming that religion served to increase the +chances of survival for early humans. Religion helped bond bickering +individuals into a cohesive tribe with a common mythology, which +increased the chances that the tribe would stick together and survive.) + +Would an experiment like the one using the “God helmet” shake a +person’s religious beliefs? And can an MRI machine record the brain +activity of someone who experiences a religious awakening?" +"To test these ideas, Dr. Mario Beauregard of the University of +Montreal recruited a group of fifteen Carmelite nuns who agreed to put +their heads into an MRI machine. To qualify for the experiment, all of +them must “have had an experience of intense union with God.” + +Originally, Dr. Beauregard had hoped that the nuns would have a +mystical communion with God, which could then be recorded by an MRI +scan. However, being shoved into an MRI machine, where you are +surrounded by tons of magnetic coils of wire and high-tech equipment, is +not an ideal setting for a religious epiphany. The best they could do was +to evoke memories of previous religious experiences. “God cannot be + + summoned at will,” explained one of the nuns. + +The final result was mixed and inconclusive, but several regions of the +brain clearly lit up during this experiment: + +• The caudate nucleus, which is involved with learning and possibly +falling in love. (Perhaps the nuns were feeling the unconditional +love of God?)" +"• The insula, which monitors body sensations and social emotions. +(Perhaps the nuns were feeling close to the other nuns as they were +reaching out to God?) + +• The parietal lobe, which helps process spatial awareness. (Perhaps +the nuns felt they were in the physical presence of God?) + +Dr. Beauregard had to admit that so many areas of the brain were +activated, with so many different possible interpretations, that he could +not say for sure whether hyperreligiosity could be induced. However, it +was clear to him that the nuns’ religious feelings were reflected in their +brain scans. + +But did this experiment shake the nuns’ belief in God? No. In fact, the + +nuns concluded that God placed this “radio” in the brain so that we +could communicate with Him." +"nuns concluded that God placed this “radio” in the brain so that we +could communicate with Him. + +Their conclusion was that God created humans to have this ability, so +the brain has a divine antenna given to us by God so that we can feel His +presence. David Biello concludes, “Although atheists might argue that +finding spirituality in the brain implies that religion is nothing more +than divine delusion, the nuns were thrilled by their brain scans for +precisely the opposite reason: they seemed to provide confirmation of +God’s interactions with them.” Dr. Beauregard concluded, “If you are an +atheist and you live a certain kind of experience, you will relate it to the +magnificence of the universe. If you are a Christian, you will associate it +with God. Who knows. Perhaps they are the same thing.” + +Similarly, Dr. Richard Dawkins, a biologist at Oxford University and +an outspoken atheist, was once placed in the God helmet to see if his +religious beliefs would change. + +They did not." +"They did not. + +So in conclusion, although hyperreligiosity may be induced via +temporal lobe epilepsy and even magnetic fields, there is no convincing +evidence that magnetic fields can alter one’s religious views. + + MENTAL ILLNESS + +But there is another altered state of consciousness that brings great +suffering, both to the person experiencing it and to his or her family, and +this is mental illness. Can brain scans and high technology reveal the +origin of this affliction and perhaps lead to a cure? If so, one of the +largest sources of human suffering could be eliminated." +"For example, throughout history, the treatment of schizophrenia was +brutal and crude. People who suffer from this debilitating mental +disorder, which afflicts about 1 percent of the population, typically hear +imaginary voices and suffer from paranoid delusions and disorganized +thinking. Throughout history, they were considered to be “possessed” by +the devil and were banished, killed, or locked up. Gothic novels +sometimes refer to the strange, demented relative who lives in the +darkness of a hidden room or basement. The Bible even mentions an +incident when Jesus encountered two demoniacs. The demons begged + +Jesus to drive them into a herd of swine. He said, “Go then.” When the +demons entered the swine, the whole herd rushed down the bank and +drowned in the sea." +"Even today, you still see people with classic symptoms of +schizophrenia walking around having arguments with themselves. The +first indicators usually surface in the late teens (for men) or early +twenties (for women). Some schizophrenics have led normal lives and +even performed remarkable feats before the voices finally took over. The +most famous case is that of the 1994 Nobel Prize winner in economics, +John Nash, who was played by Russell Crowe in the movie A Beautiful +Mind. In his twenties, Nash did pioneering work in economics, game +theory, and pure mathematics at Princeton University. One of his +advisers wrote him a letter of recommendation with just one line: “This +man is a genius.” Remarkably, he was able to perform at such a high +intellectual level even while being hounded by delusions. He was finally +hospitalized when he had a breakdown at age thirty-one, and spent +many years in institutions or wandering around the world, fearing that +communist agents would kill him." +"At present, there is no precise, universally accepted way to diagnose +mental illness. There is hope, however, that one day scientists will use +brain scans and other high-tech devices to create accurate diagnostic +tools. Progress in treating mental illness, therefore, has been painfully +slow. After centuries of suffering, victims of schizophrenia had their first +sign of relief when antipsychotic drugs like thorazine were found + + accidentally in the 1950s that could miraculously control or even at +times eliminate the voices that haunted the mentally ill." +"It is believed that these drugs work by regulating the level of certain +neurotransmitters, such as dopamine. Specifically, the theory is that +these drugs block the functioning of D2 receptors of certain nerve cells, +thereby reducing the level of dopamine. (This theory, that hallucinations +were in part caused by excess dopamine levels in the limbic system and +prefrontal cortex, also explained why people taking amphetamines +experienced similar hallucinations.) + +Dopamine, because it is so essential for the synapses of the brain, has +been implicated in other disorders as well. One theory holds that +Parkinson’s disease is aggravated by a lack of dopamine in the synapses, +while Tourette’s syndrome can be triggered by an overabundance of it. + +(People with Tourette’s syndrome have tics and unusual facial +movements. A small minority of them uncontrollably speak obscene +words and make profane, derogatory remarks.)" +"More recently, scientists have zeroed in on another possible culprit: +abnormal glutamate levels in the brain. One reason for believing these +levels are involved is that PCP (angel dust) is known to create +hallucinations similar to those of schizophrenics by blocking a glutamate +receptor called NMDA. Clozapine, a relatively new drug for +schizophrenia that stimulates the production of glutamate, shows great +promise. + +However, these antipsychotic drugs are not a cure-all. In about 20 +percent of cases, such drugs stop all symptoms. About two-thirds find +some relief from their symptoms, but the rest are totally unaffected. +(According to one theory, antipsychotic drugs mimic a natural chemical +that is missing in schizophrenics’ brains, but it is not an exact copy. +Hence a patient has to try a variety of these antipsychotic drugs, almost +by trial and error. Moreover, they can have unpleasant side effects, so +schizophrenics often stop taking them and suffer a relapse.)" +"Recently, brain scans of schizophrenics taken while they were having +auditory hallucinations have helped explain this ancient disorder. For +example, when we silently talk to ourselves, certain parts of the brain +light up on an MRI scan, especially in the temporal lobe (such as in +Wernicke’s area). When a schizophrenic hears voices, the very same +areas of the brain light up. The brain works hard to construct a +consistent narrative, so schizophrenics try to make sense of these +unauthorized voices, believing they originate from strange sources, such +as Martians secretly beaming thoughts into their brains. Dr. Michael +Sweeney of Ohio State writes, “Neurons wired for the sensation of sound + + fire on their own, like gas-soaked rags igniting spontaneously in a hot, +dark garage. In the absence of sights and sounds in the surrounding +environment, the schizophrenic’s brain creates a powerful illusion of +reality.”" +"Notably, these voices seem to be coming from a third party, who often +gives the subject commands, which are mostly mundane but sometimes +violent. Meanwhile, the simulation centers in the prefrontal cortex seem +to be on automatic pilot, so in a way it’s as though the consciousness of +a schizophrenic is running the same sort of simulations we all do, except + +they’re done without his permission. The person is literally talking to +himself without his knowledge. + +HALLUCINATIONS + +The mind constantly generates hallucinations of its own, but for the +most part they are easily controlled. We see images that don’t exist or +hear spurious sounds, for example, so the anterior cingulate cortex is +vital to distinguish the real from the manufactured. This part of the +brain helps us distinguish between stimuli that are external and those +that are internally generated by the mind itself." +"However, in schizophrenics, it is believed that this system is damaged, +so that the person cannot distinguish real from imaginary voices. (The +anterior cingulate cortex is vital because it lies in a strategic place, +between the prefrontal cortex and the limbic system. The link between +these two areas is one of the most important in the brain, since one area +governs rational thinking, and the other emotions.) + +Hallucinations, to some extent, can be created on demand. +Hallucinations occur naturally if you place someone in a pitch-black +room, an isolation chamber, or a creepy environment with strange +noises. These are examples of “our eyes playing tricks on us.” Actually, +the brain is tricking itself, internally creating false images, trying to +make sense of the world and identify threats. This effect is called +“pareidolia.” Every time we look at clouds in the sky, we see images of +animals, people, or our favorite cartoon characters. We have no choice. +It is hardwired into our brains." +"In a sense, all images we see, both real and virtual, are hallucinations, +because the brain is constantly creating false images to “fill in the gaps.” +As we’ve seen, even real images are partly manufactured. But in the +mentally ill, regions of the brain such as the anterior cingulate cortex are +perhaps damaged, so the brain confuses reality and fantasy. + + THE OBSESSIVE MIND + +Another disorder in which drugs may be used to heal the mind is OCD +(obsessive-compulsive disorder). As we saw earlier, human + +consciousness involves mediating between a number of feedback +mechanisms. Sometimes, however, the feedback mechanisms are stuck in +the “on” position." +"One in forty Americans suffers from OCD. Cases can be mild, so that, +for example, people have to constantly go home to check that they +locked the door. The detective Adrian Monk on the TV show Monk has a +mild case of OCD. But OCD can also be so severe that people +compulsively scratch or wash their skin until it is left bleeding and raw. +Some people with OCD have been known to repeat obsessive behaviors +for hours, making it difficult to keep a job or have a family. + +Normally these types of compulsive behaviors, in moderation, are +actually good for us, since they help us keep clean, healthy, and safe. +That is why we evolved these behaviors in the first place. But someone +with OCD cannot stop this behavior, and it spirals out of control." +"Brain scans are now revealing how this takes place. They show that at +least three areas of the brain that normally help us keep ourselves +healthy get stuck in a feedback loop. First, there is the orbitofrontal +cortex, which we saw in Chapter 1 can act as a fact-checker, making sure +that we have properly locked the doors and washed our hands. It tells +us, “Hmm, something is wrong.” Second, the caudate nucleus, located in +the basal ganglia, governs learned activities that are automatic. It tells +the body to “do something.” And finally, we have the cingulate cortex, +which registers conscious emotions, including discomfort. It says, “I still +feel awful.”" +"Psychiatry professor Jeffrey Schwartz of UCLA has tried to put this all +together to explain how OCD gets out of hand. Imagine you have the +urge to wash your hands. The orbitofrontal cortex recognizes that +something is wrong, that your hands are dirty. The caudate nucleus kicks +in and causes you to automatically wash your hands. Then the cingulate +cortex registers satisfaction that your hands are clean. + +But in someone with OCD, this loop is altered. Even after he notices +that his hands are dirty and he washes them, he still has the +discomforting feeling that something is wrong, that they are still dirty. +So he is stuck in a feedback loop that won’t stop. + + In the 1960s, the drug clomipramine hydrochloride began to give OCD +patients some relief. This and other drugs developed since then raise +levels of the neurotransmitter serotonin in the body. They can reduce" +"symptoms of OCD by as much as 60 percent in clinical trials. Dr. +Schwartz says, “The brain’s gonna do what the brain’s gonna do, but you +don’t have to let it push you around.” These drugs are certainly not a +cure, but they have brought some relief to the sufferers of OCD. + +BIPOLAR DISORDER + +Another common form of mental illness is bipolar disorder, in which a +person suffers from extreme bouts of wild, delusional optimism, followed +by a crash and then periods of deep depression. Bipolar disorder also +seems to run in families and, curiously, strikes frequently in artists; +perhaps their great works of art were created during bursts of creativity +and optimism. A list of creative people who were afflicted by bipolar +disorder reads like a Who’s Who of Hollywood celebrities, musicians, +artists, and writers. Although the drug lithium seems to control many of +the symptoms of bipolar disorder, the causes are not entirely clear." +"One theory states that bipolar disorder may be caused by an +imbalance between the left and right hemispheres. Dr. Michael Sweeney +notes, “Brain scans have led researchers to generally assign negative +emotions such as sadness to the right hemisphere and positive emotions +such as joy to the left hemisphere. For at least a century, neuroscientists +have noticed a link between damage to the brain’s left hemisphere and +negative moods, including depression and uncontrollable crying. +Damage to the right, however, has been associated with a broad array of +positive emotions.”" +"So the left hemisphere, which is analytical and controls language, +tends to become manic if left to itself. The right hemisphere, on the +contrary, is holistic and tends to check this mania. Dr. V. S. +Ramachandran writes, “If left unchecked, the left hemisphere would +likely render a person delusional or manic.... So it seems reasonable to +postulate a ‘devil’s advocate’ in the right hemisphere that allows ‘you’ to +adopt a detached, objective (allocentric) view of yourself.” + +If human consciousness involves simulating the future, it has to +compute the outcomes of future events with certain probabilities. It +needs, therefore, a delicate balance between optimism and pessimism to +estimate the chances of success or failures for certain courses of action." +"But in some sense, depression is the price we pay for being able to +simulate the future. Our consciousness has the ability to conjure up all +sorts of horrific outcomes for the future, and is therefore aware of all the +bad things that could happen, even if they are not realistic." +"It is hard to verify many of these theories, since brain scans of people +who are clinically depressed indicate that many brain areas are affected. +It is difficult to pinpoint the source of the problem, but among the +clinically depressed, activity in the parietal and temporal lobes seems to +be suppressed, perhaps indicating that the person is withdrawn from the +outside world and living in their own internal world. In particular, the +ventromedial cortex seems to play an important role. This area +apparently creates the feeling that there is a sense of meaning and +wholeness to the world, so that everything seems to have a purpose. +Overactivity in this area can cause mania, in which people think they are +omnipotent. Underactivity in this area is associated with depression and +the feeling that life is pointless. So it is possible that a defect in this area +may be responsible for some mood swings. + +A THEORY OF CONSCIOUSNESS AND MENTAL ILLNESS" +"A THEORY OF CONSCIOUSNESS AND MENTAL ILLNESS + +So how does the space-time theory of consciousness apply to mental +illness? Can it give us a deeper insight into this disorder? As we +mentioned before, we define human consciousness as the process of +creating a model of our world in space and time (especially the future) +by evaluating many feedback loops in various parameters in order to +achieve a goal." +"We have proposed that the key function of human consciousness is to +simulate the future, but this is not a trivial task. The brain accomplishes +it by having these feedback loops check and balance one another. For +example, a skillful CEO at a board meeting tries to draw out the +disagreement among staff members and to sharpen competing points of +view in order to sift through the various arguments and then make a +final decision. In the same way, various regions of the brain make +diverging assessments of the future, which are given to the dorsolateral +prefrontal cortex, the CEO of the brain. These competing assessments are +then evaluated and weighed until a balanced final decision is made. + +We can now apply the space-time theory of consciousness to give us a +definition of most forms of mental illness: + +Mental illness is largely caused by the disruption of the +delicate checks and balances between competing feedback" +"loops that simulate the future (usually because one region of +the brain is overactive or underactive). + +Because the CEO of the mind (the dorsolateral prefrontal cortex) no +longer has a balanced assessment of the facts, due to this disruption in +feedback loops, it begins to make strange conclusions and act in bizarre +ways. The advantage of this theory is that it is testable. One has to +perform MRI scans of the brain of someone who is mentally ill as it +exhibits dysfunctional behavior, evaluating how its feedback loops are +performing, and compare it to the MRI scans of normal people. If this +theory is correct, the dysfunctional behavior (for example, hearing +voices or becoming obsessed) can be traced back to a malfunctioning of +the checks and balances between feedback loops. The theory can be +disproven if this dysfunctional behavior is totally independent of the +interplay between these regions of the brain." +"Given this new theory of mental illness, we can now apply it to +various forms of mental disorders, summarizing the previous discussion +in this new light. + +We saw earlier that the obsessive behavior of people suffering from +OCD might arise when the checks and balances between several +feedback loops are thrown out of balance: one registering something as +amiss, another carrying out corrective action, and another one signaling +that the matter has been taken care of. The failure of the checks and +balances within this loop can cause the brain to be locked into a vicious +cycle, so the mind never believes that the problem has been resolved." +"The voices heard by schizophrenics might arise when several feedback +loops are no longer balancing one another. One feedback loop generates +spurious voices in the temporal cortex (i.e., the brain is talking to itself). +Auditory and visual hallucinations are often checked by the anterior +cingulate cortex, so a normal person can differentiate between real and +fictitious voices. But if this region of the brain is not working properly, +the brain is flooded with disembodied voices that it believes are real. + +This can cause schizophrenic behavior. + +Similarly, the manic-depressive swings of someone with bipolar +disorder might be traced to an imbalance between the left and right +hemispheres. The necessary interplay between optimistic and pessimistic +assessments is thrown off balance, and the person oscillates wildly +between these two diverging moods." +"Paranoia may also be viewed in this light. It results from an imbalance +between the amygdala (which registers fear and exaggerates threats) and +the prefrontal cortex, which evaluates these threats and puts them into + + perspective. + +We should also stress that evolution has given us these feedback loops +for a reason: to protect us. They keep us clean, healthy, and socially +connected. The problem occurs when the dynamic between opposing +feedback loops is disrupted. + +This theory can be roughly summarized as follows: + +MENTAL ILLNESS + +Paranoia + +FEEDBACK LOOP #1 + +Perceiving a threat + +FEEDBACK LOOP #2 + +Discounting threats + +BRAIN REGION AFFECTED + +Amygdala/prefrontal lobe + +MENTAL ILLNESS + +Schizophrenia + +FEEDBACK LOOP #1 + +Creating voices + +FEEDBACK LOOP #2 + +Discounting voices + +BRAIN REGION AFFECTED + +Left temporal lobe/anterior cingulate cortex + +MENTAL ILLNESS + +Bipolar disorder + + FEEDBACK LOOP #1 + +Optimism + +FEEDBACK LOOP #2 + +Pessimism + +BRAIN REGION AFFECTED + +Left/right hemisphere" +"Optimism + +FEEDBACK LOOP #2 + +Pessimism + +BRAIN REGION AFFECTED + +Left/right hemisphere + +MENTAL ILLNESS + +OCD + +FEEDBACK LOOP #1 + +Anxiety + +FEEDBACK LOOP #2 + +Satisfaction + +BRAIN REGION AFFECTED + +Orbitofrontal cortex/caudate nucleus/cingulate cortex + +According to the space-time theory of consciousness, many forms of mental illness are typified by the +disruption of the +checks and balances of opposing feedback loops in the brain that simulate the future. Brain scans are +gradually +identifying which regions these are. A more complete understanding of mental illness will undoubtedly +reveal the +involvement of many more regions of the brain. This is only a preliminary sketch. + +DEEP BRAIN STIMULATION + +Although the space-time theory of consciousness may give us insight into +the origin of mental illness, it doesn’t tell us how to create new therapies +and remedies." +"How will science deal with mental illness in the future? This is hard to +predict, since we now realize that mental illness is not just one category, +but an entire range of illnesses that can afflict the mind in a bewildering +number of ways. Furthermore, the science behind mental illness is still in + + its infancy, with huge areas totally unexplored and unexplained. + +But a new method is being tried today to treat the unending agony of +people suffering from one of the most common yet stubbornly persistent +forms of mental disorder, depression, which afflicts twenty million +people in the United States. Ten percent of them, in turn, suffer from an +incurable form of depression that has resisted all medical advances. One +direct way of treating them, which holds much promise, is to place +probes deep inside certain regions of the brain." +"An important clue to this disorder was discovered by Dr. Helen +Mayberg and colleagues, then doing research at Washington University +Medical School. Using brain scans, they identified an area of the brain, +called Brodmann area 25 (also called the subcallosal cingulate region), +in the cerebral cortex that is consistently hyperactive in depressed +individuals for whom all other forms of treatment have been +unsuccessful." +"These scientists used deep brain stimulation (DBS) in this area, +inserting a small probe into the brain and applying an electrical shock, +much like a pacemaker. The success of DBS has been astonishing in the +treatment of various disorders. In the past decade, DBS has been used on +forty thousand patients for motor-related diseases, such as Parkinson’s +and epilepsy, which cause uncontrolled movements of the body. +Between 60 and 100 percent of patients report significant improvement +in controlling their shaking hands. More than 250 hospitals in the United +States alone now perform DBS treatments. + +But then Dr. Mayberg had the idea of applying DBS directly to +Brodmann area 25 to treat depression as well. Her team took twelve +patients who were clinically depressed and had shown no improvement +after exhaustive use of drugs, psychotherapy, and electroshock therapy." +"They found that eight of these chronically depressed individuals +immediately showed progress. Their success was so astonishing, in fact, +that other groups raced to duplicate these results and apply DBS to other +mental disorders. At present, DBS is being applied to thirty-five patients +at Emory University, and thirty at other institutions. + +Dr. Mayberg says, “Depression 1.0 was psychotherapy—people +arguing about whose fault it was. Depression 2.0 was the idea that it’s a +chemical imbalance. This is Depression 3.0. What has captured +everyone’s imagination is that, by dissecting a complex behavior + +disorder into its component systems, you have a new way of thinking +about it.”" +"disorder into its component systems, you have a new way of thinking +about it.” + + Although the success of DBS in treating depressed individuals is +remarkable, much more research needs to be done. First, it is not clear +why DBS works. It is thought that DBS destroys or impairs overactive +areas of the brain (as in Parkinson’s and Brodmann area 25) and is hence +effective only against ailments caused by such overactivity. Second, the +precision of this tool needs to be improved. Although this treatment has +been used to treat a variety of brain diseases, such as phantom limb pain +(when a person feels pain from a limb that has been amputated), +Tourette’s syndrome, and obsessive-compulsive disorder, the electrode +inserted into the brain is not precise, thus affecting perhaps several +million neurons rather than just the handful that are the source of +distress." +"Time will only improve the effectiveness of this therapy. Using MEM +technology, one can create microscopic electrodes able to stimulate only +a few neurons at a time. Nanotechnology may also make possible neural +nanoprobes that are one molecule thick, as in carbon nanotubes. And as +MRI sensitivity increases, our capability to guide these electrodes to +more specific areas of the brain should grow more precise. + +WAKING UP FROM A COMA + +Deep brain stimulation has branched into several different avenues of +research, including a beneficial side effect: increasing the number of +memory cells within the hippocampus. Yet another application is to +revive some individuals in a coma." +"Comas represent perhaps one of the most controversial forms of +consciousness, and often results in national headlines. The case of Terri +Schiavo, for example, riveted the public. Due to a heart attack, she +suffered a lack of oxygen, which caused massive brain injury. As a result, +Schiavo went into a coma in 1990. Her husband, with the approval of +doctors, wanted to allow her the dignity of dying peacefully. But her +family said this was cruelly pulling the plug on someone who still had +some responses to stimuli and might one day be miraculously revived. +They pointed out that there had been sensational cases in the past when + +coma patients suddenly regained consciousness after many years in a +vegetative state. + +Brain scans were used to settle the question. In 2003, most +neurologists, examining the CAT scans, concluded that the damage to +Schiavo’s brain was so extensive that she could never be revived, and +that she was in a permanent vegetative state (PVS). After she died in" +"2005, an autopsy confirmed these results—there was no chance of +revival. + +In some other cases involving coma patients, however, brain scans +show that the damage is not so severe, so there is a slim chance of +recovery. In the summer of 2007, a man in Cleveland woke up and +greeted his mother after undergoing deep brain stimulation. The man +had suffered extensive brain damage eight years earlier and fell into a +deep coma known as a minimally conscious state." +"Dr. Ali Rezai led the team of surgeons who performed the operation. +They inserted a pair of wires into the patient’s brain until they reached +the thalamus, which, as we have seen, is the gateway where sensory +information is first processed. By sending a low-voltage current through +these wires, the doctors were able to stimulate the thalamus, which in +turn woke the man up from his deep coma. (Usually, sending electricity +into the brain causes that part of the brain to shut down, but under +certain circumstances it can act to jolt neurons into action.)" +"Improvements in DBS technology should increase the number of +success stories in different fields. Today a DBS electrode is about 1.5 +millimeters in diameter, but it touches up to a million neurons when +inserted into the brain, which can cause bleeding and damage to blood +vessels. One to three percent of DBS patients in fact have bleeding that +can progress to a stroke. The electric charge carried by DBS probes is +also still very crude, pulsing at a constant rate. Eventually, surgeons will +be able to adjust the electrical charge carried by the electrodes so that +each probe is made for a specific person and a specific ailment. The next +generation of DBS probes is bound to be safer and more precise. + +THE GENETICS OF MENTAL ILLNESS + +Another attempt to understand and eventually treat mental illness" +"Another attempt to understand and eventually treat mental illness + +involves tracing its genetic roots. Many attempts have been made in this +area, with disappointing, mixed results. There is considerable evidence +that schizophrenia and bipolar disorder run in families, but attempts to +find the genes common to all these individuals have not been conclusive. +Occasionally scientists have followed the family trees of certain +individuals afflicted by mental illness and found a gene that is prevalent. +But attempts to generalize this result to other families have often failed. +At best, scientists have concluded that environmental factors as well as a +combination of several genes are necessary to trigger mental illness. +However, it has generally been accepted that each disorder has its own +genetic basis." +"In 2012, however, one of the most comprehensive studies ever done +showed that there could in fact be a common genetic factor to mental +illness after all. Scientists from the Harvard Medical School and +Massachusetts General Hospital analyzed sixty thousand people +worldwide and found that there was a genetic link between five major +mental illnesses: schizophrenia, bipolar disorder, autism, major +depression, and attention deficit hyperactivity disorder (ADHD). +Together they represent a significant fraction of all mentally ill patients." +"After an exhaustive analysis of the subjects’ DNA, scientists found that +four genes increased the risk of mental illness. Two of them involved the +regulation of calcium channels in neurons. (Calcium is an essential +chemical involved in the processing of neural signals.) Dr. Jordan +Smoller of the Harvard Medical School says, “The calcium channels +findings suggest that perhaps—and that is a big if—treatments to affect +calcium channeling functioning might have effects across a range of +disorders.” Already, calcium channel blockers are being used to treat +people with bipolar disorder. In the future, these blockers may be used +to treat other mental illnesses as well. + +This new result could help explain the curious fact that when mental +illness runs in a family, members may manifest different forms of +disorders. For example, if one twin has schizophrenia, then the other +twin might have a totally different disorder, such as bipolar disorder." +"The point here is that although each mental illness has its own triggers +and genes, there could be a common thread running through them as +well. Isolating the common factors among these diseases could give us a +clue to which drugs might be most effective against them. + +“What we have identified here is probably just the tip of the iceberg,” +says Dr. Smoller. “As these studies grow, we expect to find additional +genes that might overlap.” If more genes are found among these five +disorders, it could open up an entirely new approach to mental illness. + +If more common genes are found, it could mean that gene therapy +might be able to repair the damage caused by defective genes. Or it +might give rise to new drugs that could treat the illness at the neural +level. + +FUTURE AVENUES + +So at present, there is no cure for patients with mental illness. +Historically, doctors were helpless in treating them. But modern" +"medicine has given us a variety of new possibilities and therapies to +tackle this ancient problem. Just a few of them include: + +1. Finding new neurotransmitters and new drugs that regulate the +signaling of neurons. + +2. Locating the genes linked to various mental illnesses, and perhaps +using gene therapy. + +3. Using deep brain stimulation to dampen or increase neural activity +in certain areas. + +4. Using EEG, MRI, MEG, and TES to understand precisely how the +brain malfunctions. + +5. And in the chapter on reverse engineering the brain, we will +explore yet another promising avenue, imaging the entire brain and +all its neural pathways. This may finally unravel the mystery of +mental illnesses. + +But to make sense of the wide variety of mental illnesses, some +scientists believe that mental illnesses can be grouped into at least two +major groups, each one requiring a different approach: + +1. Mental disorders involving injury to the brain" +"1. Mental disorders involving injury to the brain + +2. Mental disorders triggered by incorrect wiring within the brain + +The first type includes Parkinson’s, epilepsy, Alzheimer’s, and a wide +variety of disorders caused by strokes and tumors, in which brain tissue +is actually injured or malfunctioning. In the case of Parkinson’s and +epilepsy, there are neurons in a precise area of the brain that are +overactive. In Alzheimer’s, a buildup of amyloid plaque destroys brain +tissue, including the hippocampus. In strokes and tumors, certain parts +of the brain are silenced, causing numerous behavioral problems. Each +of these disorders has to be treated differently, since each injury is +different. Parkinson’s and epilepsy may require probes to silence the +overactive areas, while damage from Alzheimer’s, strokes, and tumors is +often incurable." +"In the future, there will be advances in methods to deal with these +injured parts of the brain besides deep brain stimulation and magnetic +fields. One day stem cells may replace brain tissue that has been +damaged. Or perhaps artificial replacements can be found to compensate +for these injured areas using computers. In this case, the injured tissue is +removed or replaced, either organically or electronically. + + The second category involves disorders caused by a miswiring of the +brain. Disorders like schizophrenia, OCD, depression, and bipolar +disorder might fall into this category. Each region of the brain may be +relatively healthy and intact, but one or more of them may be miswired, +causing messages to be processed incorrectly. This category is difficult to +treat, since the wiring of the brain is not well understood. So far, the +main way to deal with these disorders is through drugs that influence +neurotransmitters, but there is still a lot of hit or miss involved here." +"But there is another altered state of consciousness that has given us +new insights into the working mind. It has also provided new +perspectives on how the brain works and what might happen if there is a +disorder. This is the field of AI, artificial intelligence. Although it is still +in its infancy, it has opened profound insights into the thinking process +and has even deepened our understanding of human consciousness. So +the questions are: Can silicon consciousness be achieved? If so, how +might it differ from human consciousness? And will it try one day to +control us? + +No, I’m not interested in developing a powerful brain. All I’m +after is just a mediocre brain, something like the President of +the American Telephone and Telegraph Company. + +—ALAN TURING + +10 THE ARTIFICIAL MIND AND SILICON +CONSCIOUSNESS + +In February 2011, history was made." +"10 THE ARTIFICIAL MIND AND SILICON +CONSCIOUSNESS + +In February 2011, history was made. + +An IBM computer called Watson did what many critics thought was +impossible: it beat two contestants on a TV game show called Jeopardy! +Millions of viewers were glued to the screen as Watson methodically +annihilated its opponents on national TV, answering questions that +stumped the rival contestants, and thereby claiming the $1 million prize +money. + +IBM pulled out all the stops in assembling a machine with a truly +monumental amount of computational firepower. Watson can process +data at the astonishing rate of five hundred gigabytes per second (or the +equivalent of a million books per second) with sixteen trillion bytes of +RAM memory. It also had access to two hundred million pages of +material in its memory, including the entire storehouse of knowledge + + within Wikipedia. Watson could then analyze this mountain of +information on live TV." +"within Wikipedia. Watson could then analyze this mountain of +information on live TV. + +Watson is just the latest generation of “expert systems,” software +programs that use formal logic to access vast amounts of specialized +information. (When you talk on the phone to a machine that gives you a +menu of choices, this is a primitive expert system.) Expert systems will +continue to evolve, making our lives more convenient and efficient. + +For example, engineers are currently working to create a “robo-doc,” +which will appear on your wristwatch or wall screen and give you basic +medical advice with 99 percent accuracy almost for free. You’d talk to it +about your symptoms, and it would access the databanks of the world’s +leading medical centers for the latest scientific information. This will +reduce unnecessary visits to the doctor, eliminate costly false alarms, +and make it effortless to have regular conversations with a doctor." +"Eventually we might have robot lawyers that can answer all common +legal questions, or a robo-secretary that can plan vacations, trips, and + +dinners. (Of course, for specialized services requiring professional +advice, you would still need to see a real doctor, lawyer, etc., but for +common, everyday advice, these programs would suffice.) + +In addition, scientists have created “chat-bots” that can mimic +ordinary conversations. The average person may know tens of thousands +of words. Reading the newspaper may require about two thousand words +or more, but a casual conversation usually involves only a few hundred. +Robots can be programmed to converse with this limited vocabulary (as +long as the conversation is limited to certain well-defined subjects). + +MEDIA HYPE—THE ROBOTS ARE COMING" +"MEDIA HYPE—THE ROBOTS ARE COMING + +Soon after Watson won that contest, some pundits were wringing their +hands, mourning the day when the machines will take over. Ken +Jennings, one of the contestants defeated by Watson, remarked to the +press, “I for one welcome our new computer overlords.” The pundits +asked, If Watson could defeat seasoned game show contestants in a +head-to-machine contest, then what chance do the rest of us mortals +have to stand up to the machines? Half jokingly, Jennings said, “Brad +[the other contestant] and I were the first knowledge-industry workers +put out of work by the new generation of ‘thinking’ machines.” + +The commentators, however, forgot to mention that you could not go +up to Watson and congratulate it for winning. You could not slap it on" +"its back, or share a champagne toast with it. It wouldn’t know what any +of that meant, and in fact Watson was totally unaware that it had won at +all. All the hype aside, the truth is that Watson is a highly sophisticated +adding machine, able to add (or search data files) billions of times faster +than the human brain, but it is totally lacking in self-awareness or +common sense. + +On one hand, progress in artificial intelligence has been astounding, +especially in the area of raw computational power. Someone from the +year 1900, viewing the calculations performed by computers today, +would consider these machines to be miracles. But in another sense, +progress has been painstakingly slow in building machines that can think +for themselves (i.e., true automatons, without a puppet master, a +controller with a joystick, or someone with a remote-control panel). + +Robots are totally unaware that they are robots." +"Robots are totally unaware that they are robots. + +Given the fact that computer power has been doubling every two years +for the past fifty years under Moore’s law, some say it is only a matter of +time before machines eventually acquire self-awareness that rivals +human intelligence. No one knows when this will happen, but humanity +should be prepared for the moment when machine consciousness leaves +the laboratory and enters the real world. How we deal with robot +consciousness could decide the future of the human race. + +BOOM AND BUST CYCLES IN AI" +"BOOM AND BUST CYCLES IN AI + +It is difficult to foretell the fate of AI, since it has gone through three +cycles of boom and bust. Back in the 1950s, it seemed as if mechanical +maids and butlers were just around the corner. Machines were being +built that could play checkers and solve algebra problems. Robot arms +were developed that could recognize and pick up blocks. At Stanford +University, a robot was built called Shakey—basically a computer sitting +on top of wheels with a camera—which could wander around a room by +itself, avoiding obstacles." +"Breathless articles were soon published in science magazines heralding +the coming of the robot companion. Some predictions were too +conservative. In 1949, Popular Mechanics stated that “in the future, +computers will weigh no more than 1.5 tons.” But others were wildly +optimistic in proclaiming that the day of the robots was near. Shakey +would one day become a mechanical maid or butler that would vacuum +our carpets and open our doors. Movies like 2001: A Space Odyssey +convinced us that robots would soon be piloting our rocket ships to +Jupiter and chatting with our astronauts. In 1965, Dr. Herbert Simon, + + one of the founders of AI, said flatly, “Machines will be capable, within +20 years, of doing any work a man can do.” Two years later, another +founding father of AI, Dr. Marvin Minsky, said that “within a +generation ... the problem of creating ‘artificial intelligence’ will +substantially be solved.”" +"But all this unbounded optimism collapsed in the 1970s. Checker¬ +playing machines could only play checkers, nothing more. Mechanical +arms could pick up blocks, but nothing else. They were like one-trick + +ponies. The most advanced robots took hours just to walk across a room. +Shakey, placed in an unfamiliar environment, would easily get lost. And +scientists were nowhere near understanding consciousness. In 1974, AI +suffered a huge blow when both the U.S. and British governments +substantially curtailed funding in the field." +"But as computer power steadily increased in the 1980s, a new gold +rush occurred in AI, fueled mainly by Pentagon planners hoping to put +robot soldiers on the battlefield. Funding for AI hit a billion dollars by +1985, with hundreds of millions of dollars spent on projects like the +Smart Truck, which was supposed to be an intelligent, autonomous truck +that could enter enemy lines, do reconnaissance by itself, perform +missions (such as rescuing prisoners), and then return to friendly +territory. Unfortunately, the only thing that the Smart Truck did was get +lost. The visible failures of these costly projects created yet another AI +winter in the 1990s. + +Paul Abrahams, commenting about the years he spent at MIT as a +graduate student, has said, “It’s as though a group of people had +proposed to build a tower to the moon. Each year, they point with pride +at how much higher the tower is than it was the previous year. The only +trouble is that the moon isn’t getting much closer.”" +"But now, with the relentless march of computer power, a new AI +renaissance has begun, and slow but substantial progress has been made. +In 1997, IBM’s Deep Blue computer beat world chess champion Garry +Kasparov. In 2005, a robot car from Stanford won the DARPA Grand +Challenge for a driverless car. Milestones continue to be reached. + +This question remains: Is the third try the charm? + +Scientists now realize that they vastly underestimated the problem, +because most human thought is actually subconscious. The conscious +part of our thoughts, in fact, represents only the tiniest portion of our +computations. + +Dr. Steve Pinker says, “I would pay a lot for a robot that would put + + away the dishes or run simple errands, but I can’t, because all of the +little problems that you’d need to solve to build a robot do to that, like +recognizing objects, reasoning about the world, and controlling hands +and feet, are unsolved engineering problems.”" +"Although Hollywood movies tell us that terrifying Terminator robots +may be just around the corner, the task of creating an artificial mind has + +been much more difficult than previously thought. I once asked Dr. +Minsky when machines would equal and perhaps even surpass human +intelligence. He said that he was confident this would happen but that +he doesn’t make predictions about dates anymore. Given the roller¬ +coaster history of AI, perhaps this is the wisest approach, to map out the +future of AI without setting a specific timetable. + +PATTERN RECOGNITION AND COMMON SENSE + +There are at least two basic problems confronting AI: pattern recognition +and common sense." +"There are at least two basic problems confronting AI: pattern recognition +and common sense. + +Our best robots can barely recognize simple objects like a cup or a +ball. The robot’s eye may see details better than a natural eye, but the +robot brain cannot recognize what it is seeing. If you place a robot on a +strange, busy street, it quickly becomes disoriented and gets lost. Pattern +recognition (e.g., identifying objects) has progressed much more slowly +than previously estimated because of this problem." +"When a robot walks into a room, it has to perform trillions of +calculations, breaking down the objects it sees into pixels, lines, circles, +squares, and triangles, and then trying to make a match with the +thousands of images stored in its memory. For instance, robots see a +chair as a hodgepodge of lines and dots, but they cannot easily identify +the essence of “chairness.” Even if a robot is able to successfully match +an object to an image in its database, a slight rotation (like a chair that’s +been knocked over on the floor) or change in perspective (viewing the +chair from a different angle) will mystify the robot. Our brains, however, +automatically take different perspectives and variations into account. +Our brains are subconsciously performing trillions of calculations, but +the process seems effortless to us." +"Robots also have a problem with common sense. They do not +understand simple facts about the physical and biological world. There +isn’t an equation that can confirm something as self-evident (to us +humans) as “muggy weather is uncomfortable” or “mothers are older +than their daughters.” There has been some progress made in translating + + this sort of information into mathematical logic, but to catalog the +common sense of a four-year-old child would require hundreds of + +millions of lines of computer code. As Voltaire once said, “Common +sense is not so common.” + +For example, one of our most advanced robots is called ASIMO, built +in Japan (where 30 percent of all industrial robots are made) by the +Honda Corporation. This marvelous robot, about the size of a young boy, +can walk, run, climb stairs, speak different languages, and dance (much +better than I do, in fact). I have interacted with ASIMO on TV several +times, and was very impressed by its abilities." +"However, I met privately with the creators of ASIMO and asked them +this key question: How smart is ASIMO, if we compare it to an animal? +They admitted to me that it has the intelligence of a bug. All the walking +and talking is mostly for the press. The problem is that ASIMO is, by and +large, a big tape recorder. It has only a modest list of truly autonomous +functions, so almost every speech or motion has to be carefully scripted +ahead of time. For example, it took about three hours to film a short +sequence of me interacting with ASIMO, because the hand gesture and +other movement had to be programmed by a team of handlers." +"If we consider this in relation to our definition of human +consciousness, it seems that our current robots are stuck at a very +primitive level, simply trying to make sense of the physical and social +world by learning basic facts. As a consequence, robots are not even at +the stage where they can plot realistic simulations of the future. Asking a +robot to craft a plan to rob a bank, for instance, assumes that the robot +knows all the fundamentals about banks, such as where the money is +stored, what sort of security system is in place, and how the police and +bystanders will react to the situation. Some of this can be programmed, +but there are hundreds of nuances that the human mind naturally +understands but robots do not." +"Where robots excel is in simulating the future in just one precise field, +such as playing chess, modeling the weather, tracing the collision of +galaxies, etc. Since the laws of chess and gravity have been well known +for centuries, it is only a matter of raw computer power to simulate the +future of a chess game or a solar system. + +Attempts to move beyond this level using brute force have also +floundered. One ambitious program, called CYC, was designed to solve +the commonsense problem. CYC would include millions of lines of +computer code containing all the information of common sense and + + knowledge necessary to understand its physical and social environment. +Although CYC can process hundreds of thousands of facts and millions of +statements, it still cannot reproduce the level of thought of a four-year- +old human. Unfortunately, after some optimistic press releases, the effort +has stagnated. Many of its programmers left, deadlines have come and +gone, and yet the project still continues." +"IS THE BRAIN A COMPUTER? + +Where did we go wrong? For the past fifty years, scientists working in AI +have tried to model the brain by following the analogy with digital +computers. But perhaps this was too simplistic. As Joseph Campbell once +said, “Computers are like Old Testament gods; lots of rules and no +mercy.” If you remove a single transistor from a Pentium chip, the +computer will crash immediately. But the human brain can perform +quite well even if half of it is missing." +"This is because the brain is not a digital computer at all, but a highly +sophisticated neural network of some sort. Unlike a digital computer, +which has a fixed architecture (input, output, and processor), neural +networks are collections of neurons that constantly rewire and reinforce +themselves after learning a new task. The brain has no programming, no +operating system, no Windows, no central processor. Instead, its neural +networks are massively parallel, with one hundred billion neurons firing +at the same time in order to accomplish a single goal: to learn." +"In light of this, AI researchers are beginning to reexamine the “top- +down approach” they have followed for the last fifty years (e.g., putting +all the rules of common sense on a CD). Now AI researchers are giving +the “bottom-up approach” a second look. This approach tries to follow +Mother Nature, which has created intelligent beings (us) via evolution, +starting with simple animals like worms and fish and then creating more +complex ones. Neural networks must learn the hard way, by bumping +into things and making mistakes. + +Dr. Rodney Brooks, former director of the famed MIT Artificial +Intelligence Laboratory, and cofounder of iRobot, which makes those +mechanical vacuum cleaners found in many living rooms, introduced an +entirely new approach to AI. Instead of designing big, clumsy robots," +"why not build small, compact, insectlike robots that have to learn how +to walk, just as in nature?When I interviewed him, he told me that he +used to marvel at the mosquito, which had a nearly microscopic brain +with very few neurons, yet was able to maneuver in space better than + + any robot airplane. He built a series of remarkably simple robots, +affectionately called “insectoids” or “bugbots,” which scurried around +the floors of MIT and could run circles around the more traditional +robots. The goal was to create robots that follow the trial-and-error +method of Mother Nature. In other words, these robots learn by bumping +into things. + +(At first, it may seem that this requires a lot of programming. The +irony, however, is that neural networks require no programming at all. +The only thing that the neural network does is rewire itself, by changing +the strength of certain pathways each time it makes a right decision. So +programming is nothing; changing the network is everything.)" +"Science-fiction writers once envisioned that robots on Mars would be +sophisticated humanoids, walking and moving just like us, with complex +programming that gave them human intelligence. The opposite has +happened. Today the grandchildren of this approach—like the Mars +Curiosity rover—are now roaming over the surface of Mars. They are not +programmed to walk like a human. Instead, they have the intelligence of +a bug, but they do quite fine in this terrain. These Mars rovers have +relatively little programming; instead, they learn as they bump into +obstacles. + +ARE ROBOTS CONSCIOUS?" +"ARE ROBOTS CONSCIOUS? + +Perhaps the clearest way to see why true robot automatons do not yet +exist is to rank their level of consciousness. As we have seen in Chapter +2, we can rank consciousness in four levels. Level 0 consciousness +describes thermostats and plants; that is, it involves a few feedback loops +in a handful of simple parameters such as temperature or sunlight. Level +I consciousness describes insects and reptiles, which are mobile and have +a central nervous system; it involves creating a model of your world in +relationship to a new parameter, space. Then we have Level II +consciousness, which creates a model of the world in relationship to + +others of its kind, requiring emotions. Finally we have Level III +consciousness, which describes humans, who incorporate time and self- +awareness to simulate how things will evolve in the future and +determine our own place in these models." +"We can use this theory to rank the robots of today. The first +generation of robots were at Level 0, since they were static, without +wheels or treads. Today’s robots are at Level I, since they are mobile, but +they are at a very low echelon because they have tremendous difficulty +navigating in the real world. Their consciousness can be compared to +that of a worm or slow insect. To fully produce Level I consciousness, + + scientists will have to create robots that can realistically duplicate the +consciousness of insects and reptiles. Even insects have abilities that +current robots do not have, such as rapidly finding hiding places, +locating mates in the forest, recognizing and evading predators, or +finding food and shelter." +"As we mentioned earlier, we can numerically rank consciousness by +the number of feedback loops at each level. Robots that can see, for +example, may have several feedback loops because they have visual +sensors that can detect shadows, edges, curves, geometric shapes, etc., in +three-dimensional space. Similarly, robots that can hear require sensors +that can detect frequency, intensity, stress, pauses, etc. The total number +of these feedback loops may total ten or so (while an insect, because it +can forage in the wild, find mates, locate shelter, etc., may have fifty or +more feedback loops). A typical robot, therefore, may have Level 1:10 +consciousness." +"Robots will have to be able to create a model of the world in relation +to others if they are to enter Level II consciousness. As we mentioned +before, Level II consciousness, to a first approximation, is computed by +multiplying the number of members of its group times the number of +emotions and gestures that are used to communicate between them. +Robots would thus have a consciousness of Level 11:0. But hopefully, the +emotional robots being built in labs today may soon raise that number. + +Current robots view humans as simply a collection of pixels moving on +their TV sensors, but some AI researchers are beginning to create robots +that can recognize emotions in our facial expressions and tone of voice. +This is a first step toward robots’ realizing that humans are more than +just random pixels, and that they have emotional states." +"In the next few decades, robots will gradually rise in Level II +consciousness, becoming as intelligent as a mouse, rat, rabbit, and then a +cat. Perhaps late in this century, they will be as intelligent as a monkey, +and will begin to create goals of their own. + +Once robots have a working knowledge of common sense and the +Theory of Mind, they will be able to run complex simulations into the +future featuring themselves as the principal actors and thus enter Level +III consciousness. They will leave the world of the present and enter the +world of the future. This is many decades beyond the capability of any +robot today. Running simulations of the future means that you have a +firm grasp of the laws of nature, causality, and common sense, so that +you can anticipate future events. It also means that you understand +human intentions and motivations, so you can predict their future +behavior as well." +"The numerical value of Level III consciousness, as we mentioned, is +calculated by the total number of causal links one can make in +simulating the future in a variety of real-life situations, divided by the +average value of a control group. Computers today are able to make +limited simulations in a few parameters (e.g., the collision of two +galaxies, the flow of air around an airplane, the shaking of buildings in +an earthquake), but they are totally unprepared to simulate the future in +complex, real-life situations, so their level of consciousness would be +something like Level III: 5. + +As we can see, it may take many decades of hard work before we have +a robot that can function normally in human society. + +SPEED BUMPS ON THE WAY" +"SPEED BUMPS ON THE WAY + +So when might robots finally match and exceed humans in intelligence? +No one knows, but there have been many predictions. Most of them rely +on Moore’s law extending decades into the future. However, Moore’s law +is not a law at all, and in fact it ultimately violates a fundamental +physical law: the quantum theory. + +As such, Moore’s law cannot last forever. In fact, we can already see it +slowing down now. It might flatten out by the end of this or the next +decade, and the consequences could be dire, especially for Silicon Valley." +"The problem is simple. Right now, you can place hundreds of millions +of silicon transistors on a chip the size of your fingernail, but there is a +limit to how much you can cram onto these chips. Today the smallest +layer of silicon in your Pentium chip is about twenty atoms in width, +and by 2020 that layer might be five atoms across. But then Heisenberg’s +uncertainty principle kicks in, and you wouldn’t be able to determine +precisely where the electron is and it could “leak out” of the wire. (See +the Appendix, where we discuss the quantum theory and the uncertainty +principle in more detail.) The chip would short-circuit. In addition, it +would generate enough heat to fry an egg on it. So leakage and heat will +eventually doom Moore’s law, and a replacement will soon be necessary." +"If packing transistors on flat chips is maxing out in computing power, +Intel is making a multibillion-dollar bet that chips will rise into the third +dimension. Time will tell if this gamble pays off (one major problem +with 3-D chips is that the heat generated rises rapidly with the height of +the chip). + +Microsoft is looking into other options, such as expanding into 2-D +with parallel processing. One possibility is to spread chips horizontally + + in a row. Then you break up a software problem into pieces, sort out +each piece on a small chip, and reassemble it at the end. However, it +may be a difficult process, and software grows at a much slower pace +than the supercharged exponential rate we are accustomed to with +Moore’s law." +"These stopgap measures may add years to Moore’s law. But eventually, +all this must pass, too: the quantum theory inevitably takes over. This +means that physicists are experimenting with a wide variety of +alternatives after the Age of Silicon draws to a close, such as quantum +computers, molecular computers, nanocomputers, DNA computers, +optical computers, etc. None of these technologies, however, is ready for +prime time. + +THE UNCANNY VALLEY + +But assume for the moment that one day we will coexist with incredibly +sophisticated robots, perhaps using chips with molecular transistors +instead of silicon. How closely do we want our robots to look like us?" +"Japan is the world’s leader in creating robots that resemble cuddly pets +and children, but their designers are careful not to make their robots +appear too human, which can be unnerving. This phenomenon was first +studied by Dr. Masahiro Mori in Japan in 1970, and is called the +“uncanny valley.” It posits that robots look creepy if they look too much +like humans. (The effect was actually first mentioned by Darwin in 1839 +in The Voyage of the Beagle and again by Freud in 1919 in an essay titled +“The Uncanny.”) Since then, it has been studied very carefully not just +by AI researchers but also by animators, advertisers, and anyone +promoting a product involving humanlike figures. For instance, in a +review of the movie The Polar Express, a CNN writer noted, “Those +human characters in the film come across as downright ... well, creepy. +So The Polar Express is at best disconcerting, and at worst, a wee bit +horrifying.”" +"According to Dr. Mori, the more a robot looks like a human, the more +we feel empathy toward it, but only up to a point. There is a dip in +empathy as the robot approaches actual human appearance—hence the +uncanny valley. If the robot looks very similar to us save for a few +features that are “uncanny,” it creates a feeling of revulsion and fear. If +the robot appears 100 percent human, indistinguishable from you and +me, then we’ll register positive emotions again. + +This has practical implications. For example, should robots smile? At +first, it seems obvious that robots should smile to greet people and make" +"them feel comfortable. Smiling is a universal gesture that signals warmth +and welcome. But if the robot smile is too realistic, it makes people’s +skin crawl. (For example, Halloween masks often feature fiendish- +looking ghouls that are grinning.) So robots should smile only if they are +childlike (i.e., with big eyes and a round face) or are perfectly human, +and nothing in between. (When we force a smile, we activate facial +muscles with our prefrontal cortex. But when we smile because we are in +a good mood, our nerves are controlled by our limbic system, which +activates a slightly different set of muscles. Our brains can tell the subtle +difference between the two, which was beneficial for our evolution.) + +This effect can also be studied using brain scans. Let’s say that a +subject is placed into an MRI machine and is shown a picture of a robot +that looks perfectly human, except that its bodily motions are slightly +jerky and mechanical. The brain, whenever it sees anything, tries to" +"predict that object’s motion into the future. So when looking at a robot +that appears to be human, the brain predicts that it will move like a +human. But when the robot moves like a machine, there is a mismatch, +which makes us uncomfortable. In particular, the parietal lobe lights up +(specifically, the part of the lobe where the motor cortex connects with +the visual cortex). It is believed that mirror neurons exist in this area of +the parietal lobe. This makes sense, because the visual cortex picks up +the image of the humanlike robot, and its motions are predicted via the +motor cortex and by mirror neurons. Finally, it is likely that the +orbitofrontal cortex, located right behind the eyes, puts everything +together and says, “Hmmm, something is not quite right.”" +"Hollywood filmmakers are aware of this effect. When spending +millions on making a horror movie, they realize that the scariest scene is +not when a gigantic blob or Frankenstein’s monster pounces out of the +bushes. The scariest scene is when there is a perversion of the ordinary. +Think of the movie The Exorcist What scene made moviegoers vomit as +they ran to escape the theater or faint right in their seats? Was it the +scene when a demon appears? No. Theaters across the world erupted in +shrill screams and loud sobs when Linda Blair turned her head +completely around." +"This effect can also be demonstrated in young monkeys. If you show +them pictures of Dracula or Frankenstein, they simply laugh and rip the +pictures apart. But what sends these young monkeys screaming in terror +is a picture of a decapitated monkey. Once again, it is the perversion of +the ordinary that elicits the greatest fear. (In Chapter 2, we mentioned +that the space-time theory of consciousness explains the nature of +humor, since the brain simulates the future of a joke, and then is +surprised to hear the punch line. This also explains the nature of horror. +The brain simulates the future of an ordinary, mundane event, but then + + is shocked when things suddenly become horribly perverted.) + +For this reason, robots will continue to look somewhat childlike in +appearance, even as they approach human intelligence. Only when +robots can act realistically like humans will their designers make them +look fully human. + +SILICON CONSCIOUSNESS" +"SILICON CONSCIOUSNESS + +As we’ve seen, human consciousness is an imperfect patchwork of +different abilities developed over millions of years of evolution. Given +information about their physical and social world, robots may be able to +create simulations similar (or in some respects, even superior) to ours, +but silicon consciousness might differ from ours in two key areas: +emotions and goals. + +Historically, AI researchers ignored the problem of emotions, +considering it a secondary issue. The goal was to create a robot that was +logical and rational, not scatterbrained and impulsive. Hence, the +science fiction of the 1950s and ’60s stressed robots (and humanoids like +Spock on Star Trek ) that had perfect, logical brains." +"We saw with the uncanny valley that robots will have to look a certain +way if they’re to enter our homes, but some people argue that robots +must also have emotions so that we can bond with, take care of, and +interact productively with them. In other words, robots will need Level II +consciousness. To accomplish this, robots will first have to recognize the +full spectrum of human emotions. By analyzing subtle facial movements +of the eyebrows, eyelids, lips, cheeks, etc., a robot will be able to +identify the emotional state of a human, such as its owner. One +institution that has excelled in creating robots that recognize and mimic +emotion is the MIT Media Laboratory. I have had the pleasure of visiting +the laboratory, outside Boston, on several occasions, and it is like +visiting a toy factory for grown-ups. Everywhere you look, you see +futuristic, high-tech devices designed to make our lives more interesting, +enjoyable, and convenient." +"As I looked around the room, I saw many of the high-tech graphics +that eventually found their way into Hollywood movies like Minority +Report and AI. As I wandered through this playground of the future, I +came across two intriguing robots, Huggable and Nexi. Their creator, Dr. +Cynthia Breazeal, explained to me that these robots have specific goals. +Huggable is a cute teddy bear-like robot that can bond with children. It +can identify the emotions of children; it has video cameras for eyes, a +speaker for its mouth, and sensors in its skin (so it can tell when it is +being tickled, poked, or hugged). Eventually, a robot like this might +become a tutor, babysitter, nurse’s aide, or a playmate. + + Nexi, on the other hand, can bond with adults. It looks a little like the +Pillsbury Doughboy. It has a round, puffy, friendly face, with large eyes" +"that can roll around. It has already been tested in a nursing home, and +the elderly patients all loved it. Once the seniors got accustomed to Nexi, +they would kiss it, talk to it, and miss it when it had to leave. (See +Figure 12.) + +Dr. Breazeal told me she designed Huggable and Nexi because she was +not satisfied with earlier robots, which looked like tin cans full of wires, +gears, and motors. In order to design a robot that could interact +emotionally with people, she needed to figure out how she could get it +to perform and bond like us. Plus, she wanted robots that weren’t stuck +on a laboratory shelf but could venture out into the real world. The +former director of MIT’s Media Lab, Dr. Frank Moss, says, “That is why +Breazeal decided in 2004 that it was time to create a new generation of +social robots that could live anywhere: homes, schools, hospitals, elder +care facilities, and so on.”" +"At Waseda University in Japan, scientists are working on a robot that +has upper-body motions representing emotions (fear, anger, surprise, +joy, disgust, sadness) and can hear, smell, see, and touch. It has been +programmed to carry out simple goals, such as satisfying its hunger for +energy and avoiding dangerous situations. Their goal is to integrate the +senses with the emotions, so that the robot acts appropriately in +different situations. + +Figure 12. Huggable (top) and Nexi (bottom), two robots built at the MIT Media Laboratory that were +explicitly designed + +to interact with humans via emotions, (illustration credit 10.1) + +(illustration credit 10.2) + +Not to be outdone, the European Commission is funding an ongoing +project, called Feelix Growing, which seeks to promote artificial +intelligence in the UK, France, Switzerland, Greece, and Denmark. + +EMOTIONAL ROBOTS + + Meet Nao." +"EMOTIONAL ROBOTS + + Meet Nao. + +When he’s happy, he will stretch out his arms to greet you, wanting a +big hug. When he’s sad, he turns his head downward and appears +forlorn, with his shoulders hunched forward. When he’s scared, he +cowers in fear, until someone pats him reassuringly on the head. + +He’s just like a one-year-old boy, except that he’s a robot. Nao is about +one and a half feet tall, and looks very much like some of the robots you +see in a toy store, like the Tranformers, except he’s one of the most +advanced emotional robots on earth. He was built by scientists at the + +UK’s University of Hertfordshire, whose research was funded by the +European Union. + +His creators have programmed him to show emotions like happiness, +sadness, fear, excitement, and pride. While other robots have +rudimentary facial and verbal gestures that communicate their emotions, +Nao excels in body language, such as posture and gesture. Nao even +dances." +"Unlike other robots, which specialize in mastering just one area of the +emotions, Nao has mastered a wide range of emotional responses. First, +Nao locks onto visitors’ faces, identifies them, and remembers his +previous interactions with each of them. Second, he begins to follow +their movements. For example, he can follow their gaze and tell what +they are looking at. Third, he begins to bond with them and learns to +respond to their gestures. For example, if you smile at him, or pat him +on his head, he knows that this is a positive sign. Because his brain has +neural networks, he learns from interactions with humans. Fourth, Nao +exhibits emotions in response to his interactions with people. (His +emotional responses are all preprogrammed, like a tape recorder, but he +decides which emotion to choose to fit the situation.) And lastly, the +more Nao interacts with a human, the better he gets at understanding +the moods of that person and the stronger the bond becomes." +"Not only does Nao have a personality, he can actually have several of +them. Because he learns from his interactions with humans and each +interaction is unique, eventually different personalities begin to emerge. +For example, one personality might be quite independent, not requiring +much human guidance. Another personality might be timid and fearful, +scared of objects in a room, constantly requiring human intervention. + +The project leader for Nao is Dr. Lola Canamero, a computer scientist +at the University of Hertfordshire. To start this ambitious project, she +analyzed the interactions of chimpanzees. Her goal was to reproduce, as +closely as she could, the emotional behavior of a one-year-old + + chimpanzee." +"chimpanzee. + +She sees immediate applications for these emotional robots. Like Dr. +Breazeal, she wants to use these robots to relieve the anxiety of young +children who are in hospitals. She says, “We want to explore different +roles—the robots will help the children to understand their treatment, +explain what they have to do. We want to help the children to control + +their anxiety.” + +Another possibility is that the robots will become companions at +nursing homes. Nao could become a valuable addition to the staff of a +hospital. At some point, robots like these might become playmates to +children and a part of the family." +"“It’s hard to predict the future, but it won’t be too long before the +computer in front of you will be a social robot. You’ll be able to talk to +it, flirt with it, or even get angry and yell at it—and it will understand +you and your emotions,” says Dr. Terrence Sejnowski of the Salk +Institute, near San Diego. This is the easy part. The hard part is to gauge +the response of the robot, given this information. If the owner is angry +or displeased, the robot has to be able to factor this into its response. + +EMOTIONS: DETERMINING WHAT IS IMPORTANT" +"EMOTIONS: DETERMINING WHAT IS IMPORTANT + +What’s more, AI researchers have begun to realize that emotions may be +a key to consciousness. Neuroscientists like Dr. Antonio Damasio have +found that when the link between the prefrontal lobe (which governs +rational thought) and the emotional centers (e.g., the limbic system) is +damaged, patients cannot make value judgments. They are paralyzed +when making the simplest of decisions (what things to buy, when to set +an appointment, which color pen to use) because everything has the +same value to them. Hence, emotions are not a luxury; they are +absolutely essential, and without them a robot will have difficulty +determining what is important and what is not. So emotions, instead of +being peripheral to the progress of artificial intelligence, are now +assuming central importance." +"If a robot encounters a raging fire, it might rescue the computer files +first, not the people, since its programming might say that valuable +documents cannot be replaced but workers always can be. It is crucial +that robots be programmed to distinguish between what is important +and what is not, and emotions are shortcuts the brain uses to rapidly +determine this. Robots would thus have to be programmed to have a +value system—that human life is more important than material objects, + + that children should be rescued first in an emergency, that objects with a +higher price are more valuable than objects with a lower price, etc. Since + +robots do not come equipped with values, a huge list of value judgments +must be uploaded into them." +"The problem with emotions, however, is that they are sometimes +irrational, while robots are mathematically precise. So silicon +consciousness may differ from human consciousness in key ways. For +example, humans have little control over emotions, since they happen so +rapidly and because they originate in the limbic system, not the +prefrontal cortex of the brain. Furthermore, our emotions are often +biased. Numerous tests have shown that we tend to overestimate the +abilities of people who are handsome or pretty. Good-looking people +tend to rise higher in society and have better jobs, although they may +not be as talented as others. As the expression goes, “Beauty has its +privileges.”" +"Similarly, silicon consciousness may not take into account subtle cues +that humans use when they meet one another, such as body language. +When people enter a room, young people usually defer to older ones and +low-ranked staff members show extra courtesy to senior officials. We +show our deference in the way we move our bodies, our choice of words, +and our gestures. Because body language is older than language itself, it +is hardwired into the brain in subtle ways. Robots, if they are to interact +socially with people, will have to learn these unconscious cues. + +Our consciousness is influenced by peculiarities in our evolutionary +past, which robots will not have, so silicon consciousness may not have +the same gaps or quirks as ours. + +A MENU OF EMOTIONS + +Since emotions have to be programmed into robots from the outside, +manufacturers may offer a menu of emotions carefully chosen on the +basis of whether they are necessary, useful, or will increase bonding +with the owner." +"In all likelihood, robots will be programmed to have only a few +human emotions, depending on the situation. Perhaps the emotion most +valued by the robot’s owner will be loyalty. One wants a robot that +faithfully carries out its commands without complaints, that understands +the needs of the master and anticipates them. The last thing an owner + + will want is a robot with an attitude, one that talks back, criticizes +people, and whines. Helpful criticisms are important, but they must be +made in a constructive, tactful way. Also, if humans give it conflicting +commands, the robot should know to ignore all of them except those +coming from its owner. + +Empathy will be another emotion that will be valued by the owner. +Robots that have empathy will understand the problems of others and +will come to their aid. By interpreting facial movements and listening to +tone of voice, robots will be able to identify when a person is in distress +and will provide assistance when possible." +"Strangely, fear is another emotion that is desirable. Evolution gave us +the feeling of fear for a reason, to avoid certain things that are +dangerous to us. Even though robots will be made of steel, they should +fear certain things that can damage them, like falling off tall buildings or +entering a raging fire. A totally fearless robot is a useless one if it +destroys itself. + +But certain emotions may have to be deleted, forbidden, or highly +regulated, such as anger. Given that robots could be built to have great +physical strength, an angry robot could create tremendous problems in +the home and workplace. Anger could get in the way of its duties and +cause great damage to property. (The original evolutionary purpose of +anger was to show our dissatisfaction. This can be done in a rational, +dispassionate way, without getting angry.)" +"Another emotion that should be deleted is the desire to be in +command. A bossy robot will only make trouble and might challenge the +judgment and wishes of the owner. (This point will also be important +later, when we discuss whether robots will one day take over from +humans.) Hence the robot will have to defer to the wishes of the owner, +even if this may not be the best path. + +But perhaps the most difficult emotion to convey is humor, which is a +glue that can bond total strangers together. A simple joke can defuse a +tense situation or inflame it. The basic mechanics of humor are simple: +they involve a punch line that is unanticipated. But the subtleties of +humor can be enormous. In fact, we often size up other people on the +basis of how they react to certain jokes. If humans use humor as a gauge +to measure other humans, then one can appreciate the difficulty of +creating a robot that can tell if a joke is funny or not. President Ronald" +"Reagan, for example, was famous for defusing the most difficult +questions with a quip. In fact, he accumulated a large card catalog of +jokes, barbs, and wisecracks, because he understood the power of + + humor. (Some pundits concluded that he won the presidential debate +against Walter Mondale when he was asked if he was too old to be +president. Reagan replied that he would not hold the youth of his +opponent against him.) Also, laughing inappropriately could have +disastrous consequences (and is, in fact, sometimes a sign of mental +illness). The robot has to know the difference between laughing with or +at someone. (Actors are well aware of the diverse nature of laughter. +They are skilled enough to create laughter that can represent horror, +cynicism, joy, anger, sadness, etc.) So, at least until the theory of +artificial intelligence becomes more developed, robots should stay away +from humor and laughter. + +PROGRAMMING EMOTIONS" +"PROGRAMMING EMOTIONS + +In this discussion we have so far avoided the difficult question of +precisely how these emotions would be programmed into a computer. +Because of their complexity, emotions will probably have to be +programmed in stages. + +First, the easiest part is identifying an emotion by analyzing the +gestures in a person’s face, lips, eyebrows, and tone of voice. Today’s +facial recognition technology is already capable of creating a dictionary +of emotions, so that certain facial expressions mean certain things. This +process actually goes back to Charles Darwin, who spent a considerable +amount of time cataloging emotions common to animals and humans. + +Second, the robot must respond rapidly to this emotion. This is also +easy. If someone is laughing, the robot will grin. If someone is angry, the +robot will get out of his way and avoid conflict. The robot would have a +large encyclopedia of emotions programmed into it, and hence would +know how to make a rapid response to each one." +"The third stage is perhaps the most complex because it involves trying +to determine the underlying motivation behind the original emotion. +This is difficult, since a variety of situations can trigger a single emotion. +Laughter may mean that someone is happy, heard a joke, or watched + +someone fall. Or it might mean that a person is nervous, anxious, or +insulting someone. Likewise, if someone is screaming, there may be an +emergency, or perhaps someone is just reacting with joy and surprise. +Determining the reason behind an emotion is a skill that even humans +have difficulty with. To do this, the robot will have to list the various +possible reasons behind an emotion and try to determine the reason that +makes the most sense. This means trying to find a reason behind the +emotion that fits the data best." +"And fourth, once the robot has determined the origin of this emotion, +it has to make the appropriate response. This is also difficult, since there +are often several possible responses, and the wrong one may make the +situation worse. The robot already has, within its programming, a list of +possible responses to the original emotion. It has to calculate which one +will best serve the situation, which means simulating the future. + +WILL ROBOTS LIE? + +Normally, we might think of robots as being coldly analytical and +rational, always telling the truth. But once robots become integrated into +society, they will probably have to learn to lie or at least tactfully +restrain their comments." +"In our own lives, several times in a typical day we are confronted with +situations where we have to tell a white lie. If people ask us how they +look, we often dare not tell the truth. White lies, in fact, are like a grease +that makes society run smoothly. If we were suddenly forced to tell the +whole truth (like Jim Carrey in Liar Liar), we most likely would wind up +creating chaos and hurting people. People would be insulted if you told +them what they really looked like or how you really felt. Bosses would +fire you. Lovers would dump you. Friends would abandon you. Strangers +would slap you. Some thoughts are better kept confidential." +"In the same way, robots may have to learn how to lie or conceal the +truth, or else they might wind up offending people and being +decommissioned by their owners. At a party, if a robot tells the truth, it +could reflect badly on its owner and create an uproar. So if someone asks +for its opinion, it will have to learn how to be evasive, diplomatic, and +tactful. It must either dodge the question, change the subject, give + +platitudes for answers, reply with a question, or tell white lies (all things +that today’s chat-bots are increasingly good at). This means that the +robot has already been programmed to have a list of possible evasive +responses, and must choose the one that creates the fewest +complications." +"One of the few times that a robot would tell the entire truth would be +if asked a direct question by its owner, who understands that the answer +might be brutally honest. Perhaps the only other time when the robot +will tell the truth is when there is a police investigation and the absolute +truth is necessary. Other than that, robots will be able to freely lie or +conceal the whole truth to keep the wheels of society functioning. + + In other words, robots have to be socialized, just like teenagers. + +CAN ROBOTS FEEL PAIN? + +Robots, in general, will be assigned to do types of tasks that are dull, +dirty, and dangerous. There is no reason why robots can’t do repetitive +or dirty jobs indefinitely, since we wouldn’t program them to feel +boredom or disgust. The real problem emerges when robots are faced +with dangerous jobs. At that point, we might actually want to program +them to feel pain." +"We evolved the sense of pain because it helped us survive in a +dangerous environment. There is a genetic defect in which children are +born without the ability to feel pain. This is called congenital analgesia. +At first glance, this may seem to be a blessing, since these children do +not cry when they experience injury, but it is actually more of a curse. +Children with this affliction have serious problems, such as biting off +parts of their tongue, suffering severe skin burns, and cutting +themselves, often leading to amputations of their fingers. Pain alerts us +to danger, telling us when to move our hand away from the burning +stove or to stop running on a twisted ankle." +"At some point robots must be programmed to feel pain, or else they +will not know when to avoid precarious situations. The first sense of +pain they must have is hunger (i.e., a craving for electrical energy). As +their batteries run out, they will get more desperate and urgent, +realizing that soon their circuits will shut down, leaving all their work in + +disarray. The closer they are to running out of power, the more anxious +they will become. + +Also, regardless of how strong they are, robots may accidentally pick +up an object that is too heavy, which could cause their limbs to break. +Or they may suffer overheating by working with molten metal in a steel +factory, or by entering a burning building to help firemen. Sensors for +temperature and stress would alert them that their design specifications +are being exceeded." +"But once the sensation of pain is added to their menu of emotions, this +immediately raises ethical issues. Many people believe that we should +not inflict unnecessary pain on animals, and people may feel the same +about robots as well. This opens the door to robots’ rights. Laws may +have to be passed to restrict the amount of pain and danger that a robot +is allowed to face. People will not care if a robot is performing dull or +dirty tasks, but if they feel pain doing a dangerous one, they may begin + + to lobby for laws to protect robots. This may even start a legal conflict, +with owners and manufacturers of robots arguing for increasing the level +of pain that robots can endure, while ethicists may argue for lowering it." +"This, in turn, may set off other ethical debates about other robot +rights. Can robots own property? What happens if they accidentally hurt +someone? Can they be sued or punished? Who is responsible in a +lawsuit? Can a robot own another robot? This discussion raises another +sticky question: Should robots be given a sense of ethics? + +ETHICAL ROBOTS + +At first, the idea of ethical robots seems like a waste of time and effort. +However, this question takes on a sense of urgency when we realize that +robots will make life-and-death decisions. Since they will be physically +strong and have the capability of saving lives, they will have to make +split-second ethical choices about whom to save first." +"Let’s say there is a catastrophic earthquake and children are trapped in +a rapidly crumbling building. How should the robot allocate its energy? +Should it try to save the largest number of children? Or the youngest? Or +the most vulnerable? If the debris is too heavy, the robot may damage its +electronics. So the robot has to decide yet another ethical question: How + +does it weigh the number of children it saves versus the amount of +damage that it will sustain to its electronics? + +Without proper programming, the robot may simply halt, waiting for a +human to make the final decision, wasting valuable time. So someone +will have to program it ahead of time so that the robot automatically +makes the “right” decision." +"These ethical decisions will have to be preprogrammed into the +computer from the start, since there is no law of mathematics that can +put a value on saving a group of children. Within its programming, there +has to be a long list of things, ranked in terms of how important they +are. This is tedious business. In fact, it sometimes takes a human a +lifetime to learn these ethical lessons, but a robot has to learn them +rapidly, before it leaves the factory, if it is to safely enter society. + +Only people can do this, and even then ethical dilemmas sometimes +confound us. But this raises questions: Who will make the decisions? +Who decides the order in which robots save human lives? + +The question of how decisions will ultimately be made will probably" +"The question of how decisions will ultimately be made will probably + + be resolved via a combination of the law and the marketplace. Laws will +have to be passed so that there is, at minimum, a ranking of importance +of whom to save in an emergency. But beyond that, there are thousands +of finer ethical questions. These subtler decisions may be decided by the +marketplace and common sense. + +If you work for a security firm guarding important people, you will +have to tell the robot how to save people in a precise order in different +situations, based on considerations such as fulfilling the primary duty +but also doing it within budget." +"What happens if a criminal buys a robot and wants the robot to +commit a crime? This raises a question: Should a robot be allowed to +defy its owner if it is asked to break the law? We saw from the previous +example that robots must be programmed to understand the law and +also make ethical decisions. So if it decides that it is being asked to +break the law, it must be allowed to disobey its master. + +There is also the ethical dilemma posed by robots reflecting the beliefs +of their owners, who may have diverging morals and social norms. The +“culture wars” that we see in society today will only be magnified when +we have robots that reflect the opinions and beliefs of their owners. In +some sense, this conflict is inevitable. Robots are mechanical extensions + +of the dreams and wishes of their creators, and when robots are +sophisticated enough to make moral decisions, they will do so." +"The fault lines of society may be stressed when robots begin to exhibit +behaviors that challenge our values and goals. Robots owned by youth +leaving a noisy, raucus rock concert may conflict with robots owned by +elderly residents of a quiet neighborhood. The first set of robots may be +programmed to amplify the sounds of the latest bands, while the second +set may be programmed to keep noise levels to an absolute minimum. +Robots owned by devout, churchgoing fundamentalists may get into +arguments with robots owned by atheists. Robots from different nations +and cultures may be designed to reflect the mores of their society, which +may clash (even for humans, let alone robots). + +So how does one program robots to eliminate these conflicts?" +"So how does one program robots to eliminate these conflicts? + +You can’t. Robots will simply reflect the biases and prejudices of their +creators. Ultimately, the cultural and ethical differences between these +robots will have to be settled in the courts. There is no law of physics or +science that determines these moral questions, so eventually laws will +have to be written to handle these social conflicts. Robots cannot solve +the moral dilemmas created by humans. In fact, robots may amplify +them. + + But if robots can make ethical and legal decisions, can they also feel +and understand sensations? If they succeed in saving someone, can they +experience joy? Or can they even feel things like the color red? Coldly +analyzing the ethics of whom to save is one thing, but understanding +and feeling is another. So can robots feel? + +CAN ROBOTS UNDERSTAND OR FEEL?" +"CAN ROBOTS UNDERSTAND OR FEEL? + +Over the centuries, a great many theories have been advanced about +whether a machine can think and feel. My own philosophy is called +“constructivism”; that is, instead of endlessly debating the question, +which is pointless, we should be devoting our energy to creating an +automaton to see how far we can get. Otherwise we wind up in endless +philosophical debates that are never ultimately resolved. The advantage +of science is that, once everything is said and done, one can perform +experiments to settle a question decisively." +"Thus, to settle the question of whether a robot can think, the final +resolution may be to build one. Some, however, have argued that +machines will never be able to think like a human. Their strongest +argument is that, although a robot can manipulate facts faster than a +human, it does not “understand” what it is manipulating. Although it +can process senses (e.g., color, sound) better than a human, it cannot +truly “feel” or “experience” the essence of these senses. + +For example, philosopher David Chalmers has divided the problems of +AI into two categories, the Easy Problems and the Hard Problems. To +him, the Easy Problems are creating machines that can mimic more and +more human abilities, such as playing chess, adding numbers, +recognizing certain patterns, etc. The Hard Problems involve creating +machines that can understand feelings and subjective sensations, which +are called “qualia.”" +"Just as it is impossible to teach the meaning of the color red to a blind +person, a robot will never be able to experience the subjective sensation +of the color red, they say. Or a computer might be able to translate +Chinese words into English with great fluency, but it will never be able +to understand what it is translating. In this picture, robots are like +glorified tape recorders or adding machines, able to recite and +manipulate information with incredible precision, but without any +understanding whatsoever. + +These arguments have to be taken seriously, but there is also another +way of looking at the question of qualia and subjective experience. In" +"the future, a machine most likely will be able to process a sensation, +such as the color red, much better than any human. It will be able to +describe the physical properties of red and even use it poetically in a +sentence better than a human. Does the robot “feel” the color red? The +point becomes irrelevant, since the word “feel” is not well defined. At +some point, a robot’s description of the color red may exceed a human’s, +and the robot may rightly ask: Do humans really understand the color +red? Perhaps humans cannot really understand the color red with all the +nuances and subtly that a robot can. + +As behaviorist B. F. Skinner once said, “The real problem is not +whether machines think, but whether men do.” + +Similarly, it is only a matter of time before a robot will be able to +define Chinese words and use them in context much better than any" +"human. At that point, it becomes irrelevant whether the robot +“understands” the Chinese language. For all practical purposes, the +computer will know the Chinese language better than any human. In +other words, the word “understand” is not well defined. + +One day, as robots surpass our ability to manipulate these words and +sensations, it will become irrelevant whether the robot “understands” or +“feels” them. The question will cease to have any importance. + +As mathematician John von Neumann said, “In mathematics, you +don’t understand things. You just get used to them.” + +So the problem lies not in the hardware but in the nature of human +language, in which words that are not well defined mean different things +to different people. The great quantum physicist Niels Bohr was once +asked how one could understand the deep paradoxes of the quantum +theory. The answer, he replied, lies in how you define the word +“understand.”" +"Dr. Daniel Dennett, a philosopher at Tufts University, has written, +“There could not be an objective test to distinguish a clever robot from a +conscious person. Now you have a choice: you can either cling to the +Hard Problem, or you can shake your head in wonder and dismiss it. +Just let go.” + +In other words, there is no such thing as the Hard Problem. + +To the constructivist philosophy, the point is not to debate whether a +machine can experience the color red, but to construct the machine. In +this picture, there is a continuum of levels describing the words +“understand” and “feel.” (This means that it might even be possible to" +"give numerical values to the degree of understanding and feeling.) At +one end we have the clumsy robots of today, which can manipulate a +few symbols but not much more. At the other end we have humans, who +pride themselves on feeling qualia. But as time goes by, robots will +eventually be able to describe sensations better than us on any level. +Then it will be obvious that robots understand. + +This was the philosophy behind Alan Turing’s famous Turing test. He +predicted that one day a machine would be built that could answer any +question, so that it would be indistinguishable from a human. He said, +“A computer would deserve to be called intelligent if it could deceive a +human into believing that it was human.” + +Physicist and Nobel laureate Francis Crick said it best. In the last" +"Physicist and Nobel laureate Francis Crick said it best. In the last + +century, he noted, biologists had heated debates over the question “What +is life?” Now, with our understanding of DNA, scientists realize that the +question is not well defined. There are many variations, layers, and +complexities to that simple question. The question “What is life?” simply +faded away. The same may eventually apply to feeling and +understanding. + +SELF-AWARE ROBOTS + +What steps must be taken before computers like Watson have self- +awareness? To answer this question, we have to refer back to our +definition of self-awareness: the ability to put one’s self inside a model of +the environment, and then run simulations of this model into the future +to achieve a goal. This first step requires a very high level of common +sense in order to anticipate a variety of events. Then the robot has to put +itself inside this model, which requires an understanding of the various +courses of action it may take." +"At Meiji University, scientists have taken the first steps to create a +robot with self-awareness. This is a tall order, but they think they can do +it by creating robots with a Theory of Mind. They started by building +two robots. The first was programmed to execute certain motions. The +second was programmed to observe the first robot, and then to copy it. +They were able to create a second robot that could systematically mimic +the behavior of the first just by watching it. This is the first time in +history that a robot has been built specifically to have some sense of self- +awareness. The second robot has a Theory of Mind; that is, it is capable +of watching another robot and then mimicking its motions. + +In 2012, the next step was taken by scientists at Yale University who" +"In 2012, the next step was taken by scientists at Yale University who + + created a robot that passed the mirror test. When animals are placed in +front of a mirror, most of them think the image in the mirror is that of +another animal. As we recall, only a few animals have passed the mirror +test, realizing that the mirror image was a reflection of themselves. The +scientists at Yale created a robot called Nico that resembles a gangly +skeleton made of twisted wires, with mechanical arms and two bulging +eyes sitting on top. When placed in front of a mirror, Nico not only +recognized itself but could also deduce the location of objects in a room + +by looking at their images in the mirror. This is similar to what we do +when we look into a rearview mirror and infer the location of objects +behind us." +"Nico’s programmer, Justin Hart, says, “To our knowledge, this is the +first robotic system to attempt to use a mirror in this way, representing a +significant step towards a cohesive architecture that allows robots to +learn about their bodies and appearance through self-observation, and +an important capability required in order to pass the mirror test.” + +Because the robots at Meiji University and Yale University represent +the state of the art in terms of building robots with self-awareness, it is +easy to see that scientists have a long ways to go before they can create +robots with humanlike self-awareness. + +Their work is just the first step, because our definition of self- +awareness demands that the robot use this information to create +simulations of the future. This is far beyond the capability of Nico or any +other robot." +"This raises the important question: How can a computer gain full self- +awareness? In science fiction, we often encounter a situation where the +Internet suddenly becomes self-aware, as in the movie The Terminator. +Since the Internet is connected to the entire infrastructure of modern +society (e.g., our sewer system, our electricity, our telecommunications, +our weapons), it would be easy for a self-aware Internet to seize control +of society. We would be left helpless in this situation. Scientists have +written that this may happen as an example of an “emergent +phenomenon” (i.e., when you amass a sufficiently large number of +computers together, there can be a sudden phase transition to a higher +stage, without any input from the outside). + +However, this says everything and it says nothing, because it leaves +out all the important steps in between. It’s like saying that a highway +can suddenly become self-aware if there are enough roads." +"But in this book we have given a definition of consciousness and self- +awareness, so it should be possible to list the steps by which the Internet + + can become self-aware. + +First, an intelligent Internet would have to continually make models of +its place in the world. In principle, this information can be programmed +into the Internet from the outside. This would involve describing the +outside world (i.e., Earth, its cities, and its computers), all of which can + +be found on the Internet itself. + +Second, it would have to place itself in the model. This information is +also easily obtained. It would involve giving all the specifications of the +Internet (the number of computers, nodes, transmission lines, etc.) and +its relationship to the outside world." +"But step three is by far the most difficult. It means continually running +simulations of this model into the future, consistent with a goal. This is +where we hit a brick wall. The Internet is not capable of running +simulations into the future, and it has no goals. Even in the scientific +world, simulations into the future are usually done in just a few +parameters (e.g., simulating the collision of two black holes). Running a +simulation of the model of the world containing the Internet is far +beyond the programming available today. It would have to incorporate +all the laws of common sense, all the laws of physics, chemistry, and +biology, as well as facts about human behavior and human society. + +In addition, this intelligent Internet would have to have a goal. Today +it is just a passive highway, without any direction or purpose. Of course, +one can in principle impose a goal on the Internet. But let us consider +the following problem: Can you create an Internet whose goal is self- +preservation?" +"This would be the simplest possible goal, but no one knows how to +program even this simple task. Such a program, for example, would have +to stop any attempt to shut down the Internet by pulling the plug. At +present, the Internet is totally incapable of recognizing a threat to its +existence, let alone plotting ways to prevent it. (For example, an Internet +capable of detecting threats to its existence would have to be able to +identify attempts to shut down its power, cut lines of communication, +destroy its servers, disable its fiber-optic and satellite connections, etc. +Furthermore, an Internet capable of defending itself against these attacks +would have to have countermeasures for each scenario and then run +these attempts into the future. No computer on Earth is capable of doing +even a fraction of such things.) + +In other words, one day it may be possible to create self-aware robots, +even a self-aware Internet, but that day is far into the future, perhaps at +the end of this century." +"But assume for the moment that the day has arrived, that self-aware +robots walk among us. If a self-aware robot has goals that are + +compatible with our own, then this type of artificial intelligence will not +pose a problem. But what happens if the goals are different? The fear is +that humans may be outwitted by self-aware robots and then may be +enslaved. Because of their superior ability to simulate the future, the +robots could plot the outcomes of many scenarios to find the best way to +overthrow humanity. + +One way this possibility may be controlled is to make sure that the +goals of these robots are benevolent. As we have seen, simulating the +future is not enough. These simulations must serve some final goal. If a +robot’s goal is merely to preserve itself, then it would react defensively +to any attempt to pull the plug, which could spell trouble for mankind. + +WILL ROBOTS TAKE OVER?" +"WILL ROBOTS TAKE OVER? + +In almost all science-fiction tales, the robots become dangerous because +of their desire to take over. The word “robot,” in fact, comes from the +Czech word for “worker,” first seen in the 1920 play R.U.R. (Rossum’s +Universal Robots) by Karel Capek, in which scientists create a new race of +mechanical beings that look identical to humans. Soon there are +thousands of these robots performing menial and dangerous tasks. +However, humans mistreat them badly, and one day they rebel and +destroy the human race. Although these robots have taken over Earth, +they have one defect: they cannot reproduce. But at the end of the play, +two robots fall in love. So perhaps a new branch of “humanity” emerges +once again." +"A more realistic scenario comes from the movie The Terminator, in +which the military has created a supercomputer network called Skynet +that controls the entire U.S. nuclear stockpile. One day, it wakes up and +becomes sentient. The military tries to shut down Skynet but then +realizes there is a flaw in its programming: it is designed to protect itself, +and the only way to do so is by eliminating the problem—humanity. It +starts a nuclear war, which reduces humanity to a ragtag bunch of +misfits and rebels fighting the juggernaut of the machines. + +It is certainly possible that robots could become a threat. The current +Predator drone can target its victims with deadly accuracy, but it is +controlled by someone with a joystick thousands of miles away." +"According to the New York Times, the orders to fire come directly from +the president of the United States. But in the future, a Predator might +have face recognition technology and permission to fire if it is 99 +percent confident of the identity of its target. Without human +intervention, it could automatically use this technology to fire at anyone +who fits the profile. + +Now assume that such a drone suffers a breakdown, such that its facial +recognition software malfunctions. Then it becomes a rogue robot, with +permission to kill anyone in sight. Worse, imagine a fleet of such robots +controlled by a central command. If a single transistor were to blow out +in this central computer and malfunction, then the entire fleet might go +on a killing spree." +"A more subtle problem is when robots perform perfectly well, without +any malfunctions, yet there is a tiny but fatal flaw in their programming +and goals. For a robot, self-preservation is one important goal. But so is +being helpful to humans. The real problem arises when these goals +contradict each other. + +In the movie 1 , Robot, the computer system decides that humans are +self-destructive, with their never-ending wars and atrocities, and that the +only way to protect the human race is to take over and create a +benevolent dictatorship of the machine. The contradiction here is not +between two goals, but within a single goal that is not realistic. These +murderous robots do not malfunction—they logically conclude that the +only way to preserve humanity is to take control of society." +"One solution to this problem is to create a hierarchy of goals. For +example, the desire to help humans must outrank self-preservation. This +theme was explored in the movie 2001 . The computer system HAL 9000 +was a sentient computer capable of conversing easily with humans. But +the orders given to HAL 9000 were self-contradictory and could not be +logically carried out. By attempting to execute an impossible goal, it fell +off the mesa; it went crazy, and the only solution to obeying +contradictory commands from imperfect humans was to eliminate the +humans. + +The best solution might be to create a new law of robotics, which +would state that robots cannot do harm to the human race, even if there +are contradictions within their previous directives. They must be +programmed to ignore lower-level contradictions within their orders and" +"always preserve the supreme law. But this might still be an imperfect +system at best. (For example, if the robots’ central goal is to protect +humanity to the exclusion of all other goals, then it all depends on how + + the robots define the word “protect.” Their mechanical definition of this +word may differ from ours.) + +Instead of reacting with terror, some scientists, such as Dr. Douglas +Hofstadter, a cognitive scientist at Indiana University, do not fear this +possibility. When I interviewed him, he told me that robots are our +children, so why shouldn’t we love them like our own? His attitude, he +told me, is that we love our children, even though we know that they +will take over." +"When I interviewed Dr. Hans Moravec, former director of the AI +Laboratory at Carnegie Mellon University, he agreed with Dr. Hofstadter. +In his book Robot, he writes, “Unleashed from the plodding pace of +biological evolution, the children of our minds will be free to grow to +confront immense and fundamental challenges in the larger universe. +... We humans will benefit for a time from their labors, but ... like +natural children, they will seek their own fortunes, while we, their aged +parents, silently fade away.” + +Others, on the contrary, think that this is a horrible solution. Perhaps +the problem can be solved if we make changes in our goals and priorities +now, before it is too late. Since these robots are our children, we should +“teach” them to be benevolent. + +FRIENDLY AI" +"FRIENDLY AI + +Robots are mechanical creatures that we make in the laboratory, so +whether we have killer robots or friendly robots depends on the +direction of AI research. Much of the funding comes from the military, +which is specifically mandated to win wars, so killer robots are a definite +possibility. + +However, since 30 percent of all commercial robots are manufactured +in Japan, there is another possibility: robots will be designed to become +helpful playmates and workers from the very beginning. This goal is +feasible if the consumer sector dominates robotics research. The +philosophy of “friendly AI” is that inventors should create robots that, + +from the very first steps, are programmed to be beneficial to humans." +"from the very first steps, are programmed to be beneficial to humans. + +Culturally, the Japanese approach to robots is different from the +West’s. While kids in the West might feel terror watching rampaging +Terminatortype robots, kids in Japan are steeped in the Shinto religion, +which believes spirits live in all things, even mechanical robots. Instead +of being uncomfortable at the sight of robots, Japanese children squeal" +"with delight upon encountering them. It’s no wonder, therefore, that +these robots in Japan are proliferating in the marketplace and in homes. +They greet you at department stores and educate you on TV. There is +even a serious play in Japan featuring a robot. (Japan has another +reason for embracing robots. These are the future robot nurses for an +aging country. Twenty-one percent of the population is over sixty-five, +and Japan is aging faster than any other nation. In some sense, Japan is +a train wreck in slow motion. Three demographic factors are at work. +First, Japanese women have the longest life expectancy of any ethnic +group in the world. Second, Japan has one of the world’s lowest +birthrates. Third, it has a strict immigration policy, with over 99 percent +of the population being pure Japanese. Without young immigrants to +take care of the elderly, Japan may rely on robot nurses. This problem is +not restricted to Japan; Europe is next. Italy, Germany, Switzerland, and" +"not restricted to Japan; Europe is next. Italy, Germany, Switzerland, and +other European nations face similar demographic pressures. The +populations of Japan and Europe could experience severe shrinkage by +mid-century. The United States is not far behind. The birthrate of native- +born U.S. citizens has also fallen dramatically in the last few decades, +but immigration will keep the United States expanding into this century. +In other words, it could be a trilliondollar gamble to see if robots can +save us from these three demographic nightmares.)" +"Japan leads the world in creating robots that can enter our personal +lives. The Japanese have built robots that can cook (one can make a +bowl of noodles in a minute and forty seconds). When you go to a +restaurant, you can place your order on a tablet computer and the robot +cook springs into action. It consists of two large, mechanical arms, which +grab the bowls, spoons, and knives and prepare the food for you. Some +robotic cooks even resemble human ones. + +There are also musical robots for entertainment. One such robot +actually has accordion-like “lungs” by which it can generate music by +pumping air through an instrument. There are also robot maids. If you" +"carefully prepare your laundry, it can fold it in front of you. There is +even a robot that can talk because it has artificial lungs, lips, tongue, +and nasal cavity. The Sony Corporation, for example, built the AIBO +robot, which resembles a dog and can register a number of emotions if +you pet it. Some futurists predict that the robotics industry may one day +become as large as the automobile industry is today. + +The point here is that robots are not necessarily programmed to +destroy and dominate. The future of AI is up to us. + +But some critics of friendly AI claim that robots may take over not +because they are aggressive, but because we are sloppy in creating them. +In other words, if the robots take over, it will be because we + + programmed them to have conflicting goals. + +“I AM A MACHINE”" +"programmed them to have conflicting goals. + +“I AM A MACHINE” + +When I interviewed Dr. Rodney Brooks, former director of the MIT +Artificial Intelligence Lab and cofounder of iRobot, I asked him if he +thought machines would one day take over. He told me that we just +have to accept that we are machines ourselves. This means that one day, +we will be able to build machines that are just as alive as we are. But, he +cautioned, we will have to give up the concept of our “specialness.” + +This evolution in human perspective started with Nicolaus Copernicus +when he realized that the Earth was not the center of the universe, but +rather goes around the sun. It continued with Darwin, who showed that +we were similar to the animals in our evolution. And it will continue +into the future, he told me, when we realize that we are machines, +except that we are made of wetware and not hardware." +"It’s going to represent a major change in our world outlook to accept +that we, too, are machines, he believes. He writes, “We don’t like to give +up our specialness, so you know, having the idea that robots could really +have emotions, or that robots could be living creatures—I think is going +to be hard for us to accept. But we’re going to come to accept it over the +next fifty years.” + +But on the question of whether the robots will eventually take over, he +says that this will probably not happen, for a variety of reasons. First, no +one is going to accidentally build a robot that wants to rule the world. + +He says that creating a robot that can suddenly take over is like someone +accidentally building a 747 jetliner. Plus, there will be plenty of time to +stop this from happening. Before someone builds a “super-bad robot,” +someone has to build a “mildly bad robot,” and before that a “not-so-bad +robot.”" +"His philosophy is summed up when he says, “The robots are coming, +but we don’t have too much to worry about. It’s going to be a lot of fun.” +To him, the robot revolution is a certainty, and he foresees the day when +robots will surpass human intelligence. The only question is when. But +there is nothing to fear, since we will have created them. We have the +choice to create them to help, and not hinder, us. + +MERGE WITH THEM? + + If you ask Dr. Brooks how we can coexist with these super-smart robots, +his reply is straightforward: we will merge with them. With advances in +robotics and neuroprosthetics, it becomes possible to incorporate AI into +our own bodies. + +Dr. Brooks notes that the process, in some sense, has already begun. +Today, about twenty thousand people have had cochlear implants, +which have given them the gift of hearing. Sounds are picked up by a +tiny receiver, which converts sound waves to electrical signals, which +are then sent directly to the auditory nerves of the ear." +"Similarly, at the University of Southern California and elsewhere, it is +possible to take a patient who is blind and implant an artificial retina. +One method places a mini video camera in eyeglasses, which converts an +image into digital signals. These are sent wirelessly to a chip placed in +the person’s retina. The chip activates the retina’s nerves, which then +send messages down the optic nerve to the occipital lobe of the brain. In +this way, a person who is totally blind can see a rough image of familiar +objects. Another design has a light-sensitive chip placed on the retina +itself, which then sends signals directly to the optic nerve. This design +does not need an external camera. + +This also means that we can go even further and enhance ordinary +senses and abilities. With cochlear implants, it will be possible to hear +high frequencies that we have never heard before. Already with infrared" +"glasses, one can see the specific type of light that emanates from hot +objects in the dark and that is normally invisible to the human eye. With +artificial retinas, it may be possible to enhance our ability to see +ultraviolet or infrared light. (Bees, for example, can see UV light because +they have to lock onto the sun in order to navigate to a flower bed.) + +Some scientists even dream of the day when exoskeletons will have +superpowers like those found in comic books, with super strength, super +senses, and super abilities. We’d become a cyborg like Iron Man, a +normal human with superhuman abilities and powers. This means that +we might not have to worry about super-intelligent robots taking over. +We’d simply merge with them." +"This, of course, is for the distant future. But some scientists, frustrated +that robots are not leaving the factory and entering our lives, point out +that Mother Nature has already created the human mind, so why not +copy it? Their strategy is to take the brain apart, neuron by neuron, and +then reassemble it. + +But reverse engineering entails more than just creating a vast + + blueprint to create a living brain. If the brain can be duplicated down to +the last neuron, perhaps we can upload our consciousness into a +computer. We’d have the ability to leave our mortal bodies behind. This +is beyond mind over matter. This is mind without matter. + +I’m as fond of my body as anyone, but if I can be 200 with a +body of silicon, I’ll take it. + +—DANIEL HILL, COFOUNDER OF THINKING MACHINES CORP. + +11 REVERSE ENGINEERING THE BRAIN" +"—DANIEL HILL, COFOUNDER OF THINKING MACHINES CORP. + +11 REVERSE ENGINEERING THE BRAIN + +In January 2013, two bombshells were dropped that could alter the +medical and scientific landscape forever. Overnight, reverse engineering +the brain, once considered to be too complex to solve, suddenly became +a focal point of scientific rivalry and pride between the greatest +economic powers on Earth." +"First, in his State of the Union address, President Barack Obama +stunned the scientific community by announcing that federal research +funds, perhaps to the tune of $3 billion, might be allocated to the Brain +Research Through Advancing Innovative Neurotechnologies (or BRAIN) +Initiative. Like the Human Genome Project, which opened the floodgates +for genetic research, BRAIN will pry open the secrets of the brain at the +neural level by mapping its electrical pathways. Once the brain is +mapped, a host of intractable diseases like Alzheimer’s, Parkinson’s, +schizophrenia, dementia, and bipolar disorder might be understood and +possibly cured. To jump-start BRAIN, $100 million might be allocated in +2014 toward the project." +"Almost simultaneously, the European Commission announced that the +Human Brain Project would be awarded 1.19 billion euros (about $1.6 +billion) to create a computer simulation of the human brain. Using the +power of the biggest supercomputers on the planet, the Human Brain +Project will create a copy of the human brain made of transistors and +steel. + +Proponents of both projects stressed the enormous benefits of these +endeavors. President Obama was quick to point out that not only would +BRAIN alleviate the suffering of millions of people, it will also generate +new revenue streams. For every dollar spent on the Human Genome +Project, he claimed, about $140 of economic activity was generated. +Entire industries, in fact, sprouted with the completion of the Human +Genome Project. For the taxpayer, BRAIN, like the Human Genome + + Project, will be a win-win situation." +"Project, will be a win-win situation. + +Although Obama’s speech did not give details, scientists quickly filled +in many of the gaps. Neurologists pointed out that, on one hand, it is +now possible to use delicate instruments to monitor the electrical +activity of single neurons. On the other hand, using MRI machines, it is +possible to monitor the global behavior of the entire brain. What is +missing, they pointed out, is the middle ground, where most of the +interesting brain activity takes place. It is in this middle ground, +involving the pathways of thousands to millions of neurons, that there +are huge gaps in our understanding of mental disease and behavior." +"To tackle this enormous problem, scientists laid out a tentative fifteen- +year program. In the first five years, neurologists hope to monitor the +electrical activity of tens of thousands of neurons. The short-term goals +might include reconstructing the electrical activity of important parts of +animal brains, such as the medulla of the Drosophila fruit fly or the +ganglion cells in a mouse retina (which has fifty thousand neurons). + +Within ten years, that number should increase to hundreds of +thousands of neurons. This could include imaging the entire Drosophila +brain (135,000 neurons) or even the cortex of the Etruscan shrew, the +smallest known mammal, with a million neurons. + +Finally, within fifteen years, it should be possible to monitor millions +of neurons, comparable to the zebrafish brain or the entire neocortex of +a mouse. This could pave the way toward imaging parts of the brains of +primates." +"Meanwhile, in Europe, the Human Brain Project would tackle the +problem from a different point of view. Over a ten-year period, it will +use supercomputers to simulate the basic functioning of the brains of +different animals, starting with mice and working up to humans. Instead +of dealing with individual neurons, the Human Brain Project will use +transistors to mimic their behavior, so that there will be computer +modules that can act like the neocortex, the thalamus, and other parts of +the brain. + +In the end, the rivalry between these two gigantic projects could +create a windfall by generating new discoveries for treating incurable +diseases and spawning new industries. But there is also another, unstated +goal. If one can eventually simulate a human brain, does it mean that +the brain can become immortal? Does it mean that consciousness can +now exist outside the body? Some of the thorniest theological and + + metaphysical questions are raised by these ambitious projects. + +BUILDING A BRAIN" +"metaphysical questions are raised by these ambitious projects. + +BUILDING A BRAIN + +Like many other children, I used to love taking apart clocks, +disassembling them, screw for screw, and then trying to see how the +whole thing fit together. I would trace each part mentally, seeing how +one gear connected to the next one, until the whole thing fit together. I +realized the mainspring turned the main gear, which then fed a sequence +of smaller gears, which eventually turned the hands of the clock. + +Today, on a much larger scale, computer scientists and neurologists +are trying to take apart an infinitely more complex object, the most +sophisticated object we know about in the universe: the human brain. +Moreover, they wish to reassemble it, neuron by neuron." +"Because of rapid advances in automation, robotics, nanotechnology, +and neuroscience, reverse engineering the human brain is no longer idle +speculation for polite after-dinner banter. In the United States and +Europe, billions of dollars will soon be flowing into projects once +considered preposterous. Today a small band of visionary scientists are +dedicating their professional lives to a project that they may not live to +see completed. Tomorrow their ranks could swell into an entire army, +generously funded by the United States and the nations of Europe. + +If successful, these scientists could alter the course of human history. +Not only might they find new cures and therapies for mental illnesses, +they might also unlock the secret of consciousness and perhaps upload it +into a computer." +"It is a daunting task. The human brain consists of over one hundred +billion neurons, approximately as many stars as there are in the Milky +Way galaxy. Each neuron, in turn, is connected to perhaps ten thousand +other neurons, so altogether there are a total of ten million billion +possible connections (and that does not begin to compute the number of +pathways there are among this thicket of neurons). The number of +“thoughts” that a human brain can conceive of is therefore truly +astronomical and beyond human ken. + +Yet that has not stopped a small bunch of fiercely dedicated scientists +from attempting to reconstruct the brain from scratch. There is an old + +Chinese proverb, “A journey of a thousand miles begins with the first +step.” That first step was actually taken when scientists decoded, neuron +for neuron, the nervous system of a nematode worm. This tiny creature," +"called C. elegans, has 302 neurons and 7,000 synapses, all of which have +been precisely recorded. A complete blueprint of its nervous system can +be found on the Internet. (Even today, it is the only living organism to +have its entire neural structure decoded in this way.) + +At first, it was thought that the complete reverse engineering of this +simple organism would open the door to the human brain. Ironically, the +opposite has happened. Although the nematode’s neurons were finite in +number, the network is still so complex and sophisticated that it has +taken years to understand even simple facts about worm behavior, such +as which pathways are responsible for which behaviors. If even the +lowly nematode worm could elude our scientific understanding, +scientists were forced to appreciate how complex a human brain must +be. + +THREE APPROACHES TO THE BRAIN" +"THREE APPROACHES TO THE BRAIN + +Because the brain is so complex, there are at least three distinct ways in +which it can be taken apart, neuron by neuron. The first is to simulate +the brain electronically with supercomputers, which is the approach +being taken by the Europeans. The second is to map out the neural +pathways of living brains, as in BRAIN. (This task, in turn, can be further +subdivided, depending on how these neurons are analyzed—either +anatomically, neuron by neuron, or by function and activity.) And third, +one can decipher the genes that control the development of the brain, +which is an approach pioneered by billionaire Paul Allen of Microsoft." +"The first approach, simulating the brain using transistors and +computers, is forging ahead by reverse engineering the brains of animals +in a certain sequence: first a mouse, then a rat, rabbit, and a cat. The +Europeans are following the rough trail of evolution, starting with +simple brains and working upward. To a computer scientist, the solution +is raw computing power—the more, the better. And this means using +some of the largest computers on Earth to decipher the brains of mice +and men." +"Their first target is the brain of a mouse, which is one-thousandth the +size of a human brain, containing about one hundred million neurons. +The thinking process behind a mouse brain is being analyzed by the IBM +Blue Gene computer, located at the Lawrence Livermore National +Laboratory in California, where some of the biggest computers in the +world are located; they’re used to design hydrogen warheads for the +Pentagon. This colossal collection of transistors, chips, and wires +contains 147,456 processors with a staggering 150,000 gigabytes of +memory. (A typical PC may have one processor and a few gigabytes of + + memory.) + +Progress has been slow but steady. Instead of modeling the entire +brain, scientists try to duplicate just the connections between the cortex +and the thalamus, where much of brain activity is concentrated. (This +means that the sensory connections to the outside world are missing in +this simulation.)" +"In 2006, Dr. Dharmendra Modha of IBM partially simulated the mouse +brain in this way with 512 processors. In 2007, his group simulated the +rat brain with 2,048 processors. In 2009, the cat brain, with 1.6 billion +neurons and nine trillion connections, was simulated with 24,576 +processors. + +Today, using the full power of the Blue Gene computer, IBM scientists +have simulated 4.5 percent of the human brain’s neurons and synapses. +To begin a partial simulation of the human brain, one would need +880,000 processors, which might be possible around 2020. + +I had a chance to film the Blue Gene computer. To get to the +laboratory, I had to go through layers and layers of security, since it is +the nation’s premier weapons laboratory, but once you have cleared all +the checkpoints, you enter a huge, air-conditioned room housing Blue +Gene." +"The computer is truly a magnificent piece of hardware. It consists of +racks and racks of large black cabinets full of switches and blinking +lights, each about eight feet tall and roughly fifteen feet long. As I +walked among the cabinets that make up Blue Gene, I wondered what +kinds of operations it was performing. Most likely, it was modeling the +interior of a proton, calculating the decay of plutonium triggers, +simulating the collision of two black holes, and thinking of a mouse, all +at once. + +Then I was told that even this supercomputer is giving way to the next +generation, the Blue Gene/Q Sequoia, which will take computing to a +new level. In June 2012, it set the world’s record for the fastest +supercomputer. At peak speed, it can perform operations at 20.1 PFLOPS +(or 20.1 trillion floating point operations per second). It covers an area +of three thousand square feet, and gobbles up electrical energy at the +rate of 7.9 megawatts, enough power to light up a small city." +"But with all this massive computational firepower concentrated in one +computer, is it enough to rival the human brain? + +Unfortunately, no. + + These computer simulations try only to duplicate the interactions +between the cortex and the thalamus. Huge chunks of the brain are +therefore missing. Dr. Modha understands the enormity of his project. +His ambitious research has allowed him to estimate what it would take +to create a working model of the entire human brain, and not just a +portion or a pale version of it, complete with all parts of the neocortex +and connections to the senses. He envisions using not just a single Blue +Gene computer but thousands of them, which would fill up not just a +room but an entire city block. The energy consumption would be so +great that you would need a thousand-megawatt nuclear power plant to +generate all the electricity. And then, to cool off this monstrous +computer so it wouldn’t melt, you would need to divert a river and send +it through the computer circuits." +"It is remarkable that a gigantic, city-size computer is required to +simulate a piece of human tissue that weighs three pounds, fits inside +your skull, raises your body temperature by only a few degrees, uses +twenty watts of power, and needs only a few hamburgers to keep it +going. + +BUILDING A BRAIN + +But perhaps the most ambitious scientist who has joined this campaign is +Dr. Henry Markram of the Ecole Polytechnique Federate de Lausanne, in +Switzerland. He is the driving force behind the Human Brain Project, +which has received over a billion dollars of funding from the European +Commission. He has spent the last seventeen years of his life trying to + +decode the brain’s neural wiring. He, too, is using the Blue Gene +computer to reverse engineer the brain. At present, his Human Brain +Project is running up a bill of $140 million from the European Union, +and that represents only a fraction of the computer firepower he will +need in the coming decade." +"Dr. Markram believes that this is no longer a science project but an +engineering endeavor, requiring vast sums of money. He says, “To build +this—the supercomputers, the software, the research—we need around +one billion dollars. This is not expensive when one considers that the +global burden of brain disease will exceed twenty percent of the world +gross domestic project very soon.” To him, a billion dollars is nothing, +just a pittance compared to the hundreds of billions in bills stemming +from Alzheimer’s, Parkinson’s, and other related diseases when the baby +boomers retire. + +So to Dr. Markram, the solution is one of scale. Throw enough money + + at the project, and the human brain will emerge. Now that he has won +the coveted billion-dollar prize from the European Commission, his +dream may become a reality." +"He has a ready answer when asked what the average taxpayer will get +from this billion-dollar investment. There are three reasons, he says, for +embarking on this lonely but expensive quest. First, “It’s essential for us +to understand the human brain if we want to get along in society, and I +think that it is a key step in evolution. The second reason is, we cannot +keep doing animal experimentation forever.... It’s like a Noah’s Ark. It’s +like an archive. And the third reason is that there are two billion people +on this planet that are affected by mental disorder....” + +To him, it is a scandal that so little is known about mental diseases, +which cause so much suffering to millions of people. He says, “There’s +not a single neurological disease today in which anybody knows what is +malfunctioning in this circuit—which pathway, which synapse, which +neuron, which receptor. This is shocking.”" +"At first, it may sound impossible to complete this project, with so +many neurons and so many connections. It seems like a fool’s errand. +But these scientists think they have an ace in the hole. + +The human genome consists of roughly twenty-three thousand genes, +yet it can somehow create the brain, which consists of one hundred +billion neurons. It seems to be a mathematical impossibility to create the + +human brain from our genes, yet it happens every time an embryo is +conceived. How can so much information be crammed into something so +small? + +The answer, Dr. Markram believes, is that nature uses shortcuts. The +key to his approach is that certain modules of neurons are repeated over +and over again once Mother Nature finds a good template. If you look at +microscopic slices of the brain, at first you see nothing but a random +tangle of neurons. But upon closer examination, patterns of modules that +are repeated over and over appear." +"(Modules, in fact, are one reason why it is possible to assemble large +skyscrapers so rapidly. Once a single module is designed, it is possible to +repeat it endlessly on the assembly line. Then you can rapidly stack +them on top of one another to create the skyscraper. Once the +paperwork is all signed, an apartment building can be assembled using +modules in a few months.) + +The key to Dr. Markram’s Blue Brain project is the “neocortical +column,” a module that is repeated over and over in the brain. In + + humans, each column is about two millimeters tall, with a diameter of +half a millimeter, and contains sixty thousand neurons. (As a point of +comparison, rat neural modules contain only ten thousand neurons +each.) It took ten years, from 1995 to 2005, for Dr. Markram to map the +neurons in such a column and to figure out how it worked. Once that +was deciphered, he then went to IBM to create massive iterations of +these columns." +"He is the eternal optimist. In 2009, at a TED conference, he claimed he +could finish the project in ten years. (Most likely, this will be for a +stripped-down version of the human brain without any attachment to +the other lobes or to the senses.) But he has claimed, “If we build it +correctly, it should speak and have an intelligence and behave very +much as a human does.” + +Dr. Markram is a skilled defender of his work. He has an answer for +everything. When critics say that he is treading on forbidden territory, +he counters, “As scientists, we need to be not afraid of the truth. We +need to understand our brain. It’s natural that people would think that +the brain is sacred, that we shouldn’t tamper with it because it may be +where the secrets of the soul are. But I think, quite honestly, that if the +planet understood how the brain functions, we would resolve conflicts" +"everywhere. Because people would understand how trivial and how +deterministic and how controlled conflicts and reactions and +misunderstandings are.” + +When faced with the final criticism that he is “playing God,” he says, +“I think we’re far from playing God. God created the whole universe. +We’re just trying to build a little model.” + +IS IT REALLY A BRAIN? + +Although these scientists claim that their computer simulation of the +brain will begin to reach the capability of the human brain by around +2020, the main question is, How realistic is this simulation? Can the cat +simulation, for example, catch a mouse? Or play with a ball of yarn?" +"The answer is no. These computer simulations try to match the sheer +power of the neurons firing in the cat brain, but they cannot duplicate +the way in which the regions of the brain are hooked together. The IBM +simulation is only for the thalamocortical system (i.e., the channel that +connects the thalamus to the cortex). The system does not have a +physical body, and hence all the complex interactions between the brain +and the environment are missing. The brain has no parietal lobe, so it + + has no sensory or motor connections with the outside world. And even +within the thalamocortical system, the basic wiring does not respect the +thinking process of a cat. There are no feedback loops and memory +circuits for stalking prey or finding a mate. The computerized cat brain +is a blank slate, devoid of any memories or instinctual drives. In other +words, it cannot catch a mouse." +"So even if it is possible to simulate a human brain by around 2020, +you will not be able to have a simple conversation with it. Without a +parietal lobe, it would be like a blank slate without sensations, devoid of +any knowledge of itself, people, and the world around it. Without a +temporal lobe, it would not be able to talk. Without a limbic system, it +would not have any emotions. In fact, it would have less brain power +than a newborn infant. + +The challenge of hooking up the brain to the world of sensations, +emotions, language, and culture is just beginning. + +THE SLICE-AND-DICE APPROACH + +The next approach, favored by the Obama administration, is to map the +neurons of the brain directly. Instead of using transistors, this approach +analyzes the actual neural pathways of the brain. There are several +components to it." +"One way to proceed is to physically identify each and every neuron +and synapse of the brain. (The neurons are usually destroyed by this +process.) This is called the anatomical approach. Another path is to +decipher the ways in which electrical signals flow across neurons when +the brain is performing certain functions. (The latter approach, which +stresses identifying the pathways of the living brain, is the one that +seems to be favored by the Obama administration.)" +"The anatomical approach is to take apart the cells of an animal brain, +neuron by neuron, using the “slice-and-dice” method. In this way, the +full complexity of the environment, the body, and memories are already +encoded in the model. Instead of approximating a human brain by +assembling a huge number of transistors, these scientists want to identify +each neuron of the brain. After that, perhaps each neuron can be +simulated by a collection of transistors so that you’d have an exact +replica of the human brain, complete with memory, personality, and +connection to the senses. Once someone’s brain is fully reversed +engineered in this way, you should be able to have an informative +conversation with that person, complete with memories and a +personality." +"No new physics is required to finish the project. Using a device similar +to a meat sheer in a delicatessen, Dr. Gerry Rubin of the Howard Hughes +Medical Institute has been slicing the brain of a fruit fly. This is not an +easy task, since the fruit fly brain is only three hundred micrometers +across, a tiny speck compared to the human brain. The fruit fly brain +contains about 150,000 neurons. Each slice, which is only fifty-billionths +of a meter across, is meticulously photographed with an electron +microscope, and the images are fed into a computer. Then a computer +program tries to reconstruct the wiring, neuron by neuron. At the +present rate, Dr. Rubin will be able to identify every neuron in the fruit +fly brain in twenty years. + +The snail-like pace is due, in part, to current photographic technology," +"The snail-like pace is due, in part, to current photographic technology, + +since a standard scanning microscope operates at about ten million +pixels per second. (That is about a third of the resolution achieved by a +standard TV screen per second.) The goal is to have an imaging machine +that can process ten billion pixels per second, which would be a world +record. + +The problem of how to store the data pouring in from the microscope +is also staggering. Once his project gets up to speed, Rubin expects to +scan about a million gigabytes of data per day for just a single fruit fly, +so he envisions filling up huge warehouses full of hard drives. On top of +that, since every fruit fly brain is slightly different, he has to scan +hundreds of fruit fly brains in order to get an accurate approximation of +one." +"Based on working with the fruit fly brain, how long will it take to +eventually slice up the human brain? “In a hundred years, I’d like to +know how human consciousness works. The ten- or twenty-year goal is +to understand the fruit fly brain,” he says. + +This method can be speeded up with several technical advances. One +possibility is to use an automated device, so that the tedious process of +slicing the brain and analyzing each slide is done by machine. This could +rapidly reduce the time for the project. Automation, for example, vastly +reduced the cost of the Human Genome Project (although it was +budgeted at $3 billion, it was accomplished ahead of time and under +budget, which is unheard of in Washington). Another method is to use a +large variety of dyes that will tag different neurons and pathways, +making them easier to see. An alternative approach would be to create +an automated super microscope that can scan neurons one by one with +unparalleled detail." +"Given that a complete mapping of the brain and all its senses will take +up to a hundred years, these scientists feel somewhat like the medieval + + architects who designed the cathedrals of Europe, knowing that their +grandchildren would finally complete the project. + +In addition to constructing an anatomical map of the brain, neuron by +neuron, there is a parallel effort called the “Human Connectome +Project,” which uses brain scans to reconstruct the pathways connecting +various regions of the brain. + +THE HUMAN CONNECTOME PROJECT" +"THE HUMAN CONNECTOME PROJECT + +In 2010, the National Institutes of Health announced that it was +allocating $30 million, spread out over five years, to a consortium of +universities (including Washington University in St. Louis and the +University of Minnesota), and a $8.5 million grant over three years to a +consortium led by Harvard University, Massachusetts General Hospital, +and UCLA. With this level of short-term funding, of course, researchers +cannot fully sequence the entire brain, but the funding was meant to +jump-start the effort." +"Most likely, this effort will be folded into the BRAIN project, which +will vastly accelerate this work. The goal is to produce a neuronal map +of the human brain’s pathways that will elucidate brain disorders such as +autism and schizophrenia. One of the leaders of the Connectome Project, +Dr. Sebastian Seung, says, “Researchers have conjectured that the +neurons themselves are healthy, but maybe they are just wired together +in an abnormal way. But we’ve never had the technology to test that +hypothesis until now.” If these diseases are actually caused by the +miswiring of the brain, then the Human Connectome Project may give us +an invaluable clue as to how to treat these conditions." +"When considering the ultimate goal of imaging the entire human +brain, sometimes Dr. Seung despairs of ever finishing this project. He +says, “In the seventeenth century, the mathematician and philosopher +Blaise Pascal wrote of his dread of the infinite, his feeling of +insignificance at contemplating the vast reaches of outer space. And as a +scientist, I’m not supposed to talk about my feelings.... I feel curiosity, +and I feel wonder, but at times I have also felt despair.” But he and +others like him persist, even if their project will take multiple +generations to finish. They have reason to hope, since one day +automated microscopes will tirelessly take the photographs and +artificially intelligent machines will analyze them twenty-four hours a +day. But right now, just imaging the human brain with ordinary electron +microscopes would consume about one zettabyte of data, which is +equivalent to all the data compiled in the world today on the web." +"Dr. Seung even invites the public to participate in this great project by + + visiting a website called EyeWire. There, the average “citizen scientist” +can view a mass of neural pathways and is asked to color them in + +(staying within their boundaries). It’s like a virtual coloring book, except +images are of the actual neurons in the retina of an eye, taken by an +electron microscope. + +THE ALLEN BRAIN ATLAS + +Finally, there is a third way to map the brain. Instead of analyzing the +brain by using computer simulations or by identifying all the neural +pathways, yet another approach was taken with a generous grant of +$100 million from Microsoft billionaire Paul Allen. The goal was to +construct a map or atlas of the mouse brain, with the emphasis on +identifying the genes responsible for creating the brain." +"It is hoped that this understanding of how genes are expressed in the +brain will help in understanding autism, Parkinson’s, Alzheimer’s, and +other disabilities. Since a large number of mouse genes are found in +humans, it’s possible that findings here will give us insight into the +human brain. + +With this sudden infusion of funds, the project was completed in 2006, +and its results are freely available on the web. A follow-up project, the +Allen Human Brain Atlas, was announced soon afterward, with the hope +of creating an anatomically and genetically complete 3-D map of the +human brain. In 2011, the Allen Institute announced that it had mapped +the biochemistry of two human brains, finding one thousand anatomical +sites with one hundred million data points detailing how genes are +expressed in the underlying biochemistry. The study confirmed that 82 +percent of our genes are expressed in the brain." +"“Until now, a definitive map of the human brain, at this level of detail, +simply hasn’t existed,” says Dr. Allen Jones of the Allen Institute. “The +Allen Human Brain Atlas provides never-before-seen views into our most +complex and most important organ,” he adds. + +OBJECTIONS TO REVERSE ENGINEERING + +Scientists who have dedicated their lives to reverse engineering the brain +realize that decades of hard work lie ahead of them. But they are also +convinced of the practical implications of their work. They feel that even + + partial results will help decode the mystery of mental diseases that have +afflicted humans throughout our history." +"The cynics, however, may claim that, after this arduous task is +finished, we will have a mountain of data with no understanding of how +it all fits together. For example, imagine a Neanderthal who one day +comes across the complete blueprint for an IBM Blue Gene computer. All +the details are there in the blueprint, down to the very last transistor. +The blueprint is huge, taking up thousands of square feet of paper. The +Neanderthal may be dimly aware that this blueprint is the secret of a +super-powerful machine, but the sheer mass of technical data means +nothing to him. + +Similarly, the fear is that, after spending billions deciphering the +location of every neuron of the brain, we won’t be able to understand +what it all means. It may take many more decades of hard work to see +how the whole thing functions." +"For example, the Human Genome Project was a smashing success in +sequencing all the genes that make up the human genome, but it was a +huge disappointment for those who expected immediate cures for +genetic diseases. The Human Genome Project was like a gigantic +dictionary, with twenty-three thousand entries but no definitions. Page +after page of this dictionary is blank, yet the spelling of each gene is +perfect. The project was a breakthrough, but at the same time it’s just +the first step in a long journey to figure out what these genes do and +how they interact. + +Similarly, just having a complete map of every single neural +connection in the brain does not guarantee that we will know what these +neurons are doing and how they react. Reverse engineering is the easy +part; after that, the hard part begins—making sense of all this data. + +THE FUTURE" +"THE FUTURE + +But assume for now that the moment has finally arrived. With much +fanfare, scientists solemnly announce that they have successfully reverse +engineered the entire human brain. + +Then what? + +One immediate application is to find the origins of certain mental + + diseases. It’s thought that many mental diseases are not caused by the +massive destruction of neurons, but by a simple misconnection. Think of +genetic diseases that are caused by a single mutation, like Huntington’s +disease, Tay-Sachs, or cystic fibrosis. Out of three billion base pairs, a +single misspelling (or repetition) can cause uncontrollable flailing of +your limbs and convulsions, as in Huntington’s disease. Even if the +genome is 99.9999999 percent accurate, a tiny flaw might invalidate the +entire sequence. That is why gene therapy has targeted these single +mutations as possible genetic diseases that can be fixed." +"Likewise, once the brain is reverse engineered, it might be possible to +run simulations of the brain, deliberately disrupting a few connections to +see if you can induce certain illnesses. Only a handful of neurons may be +responsible for major disruptions of our cognition. Locating this tiny +collection of misfiring neurons may be one of the jobs of the reverse- +engineered brain." +"One example might be Capgras delusion, in which you see someone +you recognize as your mother, but you believe that person to be an +impostor. According to Dr. V. S. Ramachandran, this rare disease might +be due to a misconnection between two parts of the brain. The fusiform +gyrus in the temporal lobe is responsible for recognizing the face of your +mother, but the amygdala is responsible for your emotional response in +seeing your mother. When the connection between these two centers is +disrupted, an individual can recognize his mother’s face perfectly well, +but, since there is no emotional response, he is also convinced that she is +an impostor." +"Another use for the reverse-engineered brain is to pinpoint precisely +which cluster of neurons is misfiring. Deep brain stimulation, as we’ve +seen, involves using tiny probes to dampen the activity of a tiny portion +of the brain, such as Broadmann’s area 25, in the case of certain severe +forms of depression. Using the reverse-engineered map, it might be +possible to find precisely where the neurons are misfiring, which may +involve only a handful of neurons. + +A reversed-engineered brain would also be of great help to AI. Vision +and face recognition are done effortlessly by the brain, but they still +elude our most advanced computers. For example, computers can +recognize with 95 percent or greater accuracy human faces that look +straight ahead and are part of a small data bank, but if you show the" +"computer the same face from different angles or a face that’s not in the +database, the computer will most likely fail. Within .1 seconds, we can +recognize familiar faces from different angles; it’s so easy for our brains +that we are not even aware we are doing it. Reverse engineering the +brain may reveal the mystery of how this is done. + + More complicated would be diseases that involve multiple failures of +the brain, such as schizophrenia. This disorder involves several genes, +plus interactions with the environment, which in turn cause unusual +activity in several areas of the brain. But even there, a reverse- +engineered brain would be able to tell precisely how certain symptoms +(such as hallucinations) are formed, and this might pave the way for a +possible cure." +"A reverse-engineered brain would also solve such basic but unresolved +questions as how long-term memories are stored. It is known that certain +parts of the brain, such as the hippocampus and amygdala, store +memories, but how the memory is dispersed through various cortices +and then reassembled to create a memory is still unclear. + +Once the reverse-engineered brain is fully functional, then it will be +time to turn on all its circuits to see if it can respond like a human (i.e., +to see if it can pass the Turing test). Since long-term memory is already +encoded in the neurons of the reverse-engineered brain, it should be +obvious very quickly whether the brain can respond in a way +indistinguishable from a human. + +Finally, there is one impact of reverse engineering the brain that is +rarely discussed but is on many people’s minds: immortality. If +consciousness can be transferred into a computer, does that mean we +don’t have to die?" +"Speculation is never a waste of time. It clears away the +deadwood in the thickets of deduction. + +—ELIZABETH PETERS + +We are a scientific civilization.... That means a civilization in +which knowledge and its integrity are crucial. Science is only a +Latin word for knowledge.... Knowledge is our destiny. + +—JACOB BRONOWSKI + +12 THE FUTURE MIND BEYOND MATTER + +Can consciousness exist by itself, free from the constraints of the +physical body? Can we leave our mortal body and, like spirits, wander +around this playground called the universe? This was explored on Star" +"Trek, when Captain Kirk of the starship Enterprise encounters a +superhuman race, almost a million years more advanced than the +Federation of Planets. They are so advanced that they have long since +abandoned their frail, mortal bodies, and now inhabit pulsating globes of +pure energy. It has been millennia since they could feel intoxicating +sensations, such as breathing fresh air, touching another’s hand, or +feeling physical love. Their leader, Sargon, welcomes the Enterprise to +their planet. Captain Kirk accepts the invitation, acutely aware that this +civilization could instantly vaporize the Enterprise if it wanted to. + +But unknown to the crew, these super beings have a fatal weakness. +For all their advanced technology, they have been severed for hundreds +of thousands of years from their physical bodies. As such, they yearn to +feel the rush of physical sensations and long to become human again." +"One of these super beings, in fact, is evil and determined to gain +possession of the physical bodies of the crew. He wants to live like a +human, even if it means destroying the mind of the body’s owner. Soon a +battle breaks out on the deck of the Enterprise, as the evil entity seizes +control of Spock’s body and the crew fights back. + +Scientists have asked themselves, Is there a law of physics preventing +the mind from existing without the body? In particular, if the conscious +human mind is a device that constantly creates models of the world and +simulates them into the future, is it possible to create a machine that can +simulate this entire process? + +Previously, we mentioned the possibility of having our bodies placed +in pods, as in the movie Surrogates, while we mentally control a robot. +The problem here is that our natural body will still gradually wither +away, even if our robot surrogate keeps on going. Serious scientists are" +"contemplating whether we can actually transfer our minds into a robot +so we can become truly immortal. And who wouldn’t want a chance at +eternal life? As Woody Allen once said, “I don’t want to live forever +through my works. I want to live forever by not dying.” + +Actually, millions of people already claim that it is possible for the +mind to leave the body. In fact, many insist that they have done it +themselves. + +OUT-OF-BODY EXPERIENCES + +The idea of minds without bodies is perhaps the oldest of our +superstitions, embedded deep within our myths, folklore, dreams, and + + perhaps even our genes. Every society, it seems, has some tale of ghosts +and demons who can enter and leave the body at will." +"Sadly, many innocents were persecuted to exorcize the demons that +were supposedly possessing their bodies. They probably suffered from +mental illness, such as schizophrenia, in which victims are often haunted +by voices generated by their own minds. Historians believe that one of +the Salem witches who was hung in 1692 for being possessed probably +had a rare genetic condition, called Huntington’s disease, that causes +uncontrolled flailing of the limbs. + +Today some people claim that they have entered a trancelike state in +which their consciousness has left their body and is free to roam +throughout space, even able to look back at their mortal body. In a poll +of thirteen thousand Europeans, 5.8 percent claimed they had had an +out-of-body experience. Interviews with people in the United States +show similar numbers." +"Nobel laureate Richard Feynman, always curious about new +phenomena, once placed himself in a sensory deprivation tank and tried +to leave his physical body. He was successful. He would later write that +he felt that he had left his body, drifted into space, and saw his +motionless body when he looked back. However, Feynman later +concluded that this was probably just his imagination, caused by sensory +deprivation. + +Neurologists who have studied this phenomenon have a more prosaic +explanation. Dr. Olaf Blanke and his colleagues in Switzerland may have" +"located the precise place in the brain that generates out-of-body +experiences. One of his patients was a forty-three-year-old woman who +suffered from debilitating seizures that came from her right temporal +lobe. A grid of about one hundred electrodes was placed over her brain +in order to locate the region responsible for her seizures. When the +electrodes stimulated the area between the parietal and temporal lobes, +she immediately had the sensation of leaving her body. “I see myself +lying in bed, from above, but I only see my legs and lower trunk!” she +exclaimed. She felt she was floating six feet above her body." +"When the electrodes were turned off, however, the out-of-body +sensation disappeared immediately. In fact, Dr. Blanke found that he +could turn the out-of-body sensation on and off, like a light switch, by +repeatedly stimulating this area of the brain. As we saw in Chapter 9, +temporal lobe epileptic lesions can induce the feeling that there are evil +spirits behind every misfortune, so the concept of spirits leaving the +body is perhaps part of our neural makeup. (This may also explain the +presence of supernatural beings. When Dr. Blanke analyzed a twenty- + + two-year-old woman who was suffering from intractable seizures, he +found that, by stimulating the temporoparietal area of the brain, he +could induce the sensation that there was a shadowy presence behind +her. She could describe this person, who even grabbed her arms, in +detail. His position would change with each appearance, but he would +always appear behind her.)" +"Human consciousness, I believe, is the process of continually forming +a model of the world, in order to simulate the future and carry out a +goal. In particular, the brain is receiving sensations from the eyes and +inner ear to create a model of where we are in space. However, when +the signals from our eyes and ears are in contradiction, we become +confused about our location. We often get nauseous and throw up. For +example, many people develop sea sickness when they are on a rocking +boat because their eyes, looking at the cabin walls, tell them that they +are stationary, but their inner ear tells them that they are swaying. The +mismatch between these signals causes them to become nauseous. The +remedy is to look out at the horizon so that the visual image matches the +signals from the inner ear. (This same sense of nausea can be induced +even if you are stationary. If you look at a spinning garbage can with +bright vertical stripes painted on it, the stripes seem to move" +"horizontally across your eyes, giving you the sensation that you are +moving. But your inner ear says you are stationary. The resulting +mismatch causes you to throw up after a few minutes, even if you are +sitting in a chair.) + +The messages from the eyes and inner ear can also be disrupted +electrically, at the boundary of the temporal and parietal lobes, and this +is the origin of out-of-body experiences. When this sensitive area is +touched, the brain gets confused about where it is located in space. +(Notably, temporary loss of blood or oxygen or excess carbon dioxide in +the blood can also cause a disruption in the temporoparietal region and +induce out-of-body experiences, which may explain the prevalence of +these sensations during accidents, emergencies, heart attacks, etc.) + +NEAR-DEATH EXPERIENCES" +"NEAR-DEATH EXPERIENCES + +But perhaps the most dramatic category of out-of-body experiences are +the near-death stories of individuals who have been declared dead but +then mysteriously regained consciousness. In fact, 6 to 12 percent of +survivors of cardiac arrest report having near-death experiences. It’s as +though they have cheated death itself. When interviewed, they have +dramatic tales of the same experience: they left their body and drifted +toward a bright light at the end of a long tunnel." +"The media have seized upon this, with numerous best sellers and TV +documentaries devoted to these theatrical stories. Many bizarre theories +have been proposed to explain near-death experiences. In a poll of two +thousand people, fully 42 percent believed that near-death experiences +were proof of contact with the spiritual world that lies beyond death. +(Some believe that the body releases endorphins—natural narcotics— +before death. This may explain the euphoria that people feel, but not the +tunnel and the bright lights.) Carl Sagan even speculated that near-death +experiences were a reliving of the trauma of birth. The fact that these +individuals recount very similar experiences doesn’t necessarily +corroborate their glimpses into the afterlife; in fact, it seems to indicate +that there is some deep neurological event happening. + +Neurologists have looked into this phenomenon seriously and suspect +that the key may be the decrease of blood flow to the brain that often" +"accompanies near-death cases, and which also occurs in fainting. Dr. +Thomas Lempert, a neurologist at the Castle Park Clinic in Berlin, +conducted a series of experiments on forty-two healthy individuals, +causing them to faint under controlled laboratory conditions. Sixty +percent of them had visual hallucinations (e.g., bright lights and colored +patches). Forty-seven percent of them felt that they were entering +another world. Twenty percent claimed to have encountered a +supernatural being. Seventeen percent saw a bright light. Eight percent +saw a tunnel. So fainting can mimic all the sensations people have in +near-death experiences. But precisely how does this happen?" +"The mystery of how fainting can simulate near-death experiences may +be solved by analyzing the experiences of military pilots. The U.S. Air +Force, for example, contacted neurophysiologist Dr. Edward Lambert to +analyze military pilots who blacked out when experiencing high g forces +(i.e., when executing a tight turn in a jet or pulling out of a dive). Dr. +Lampert placed pilots in an ultracentrifuge at the Mayo Clinic in +Rochester, Minnesota, which spun them around in a circle until they +experienced high g forces. As blood drained from their brain, they would +become unconscious after fifteen seconds of experiencing several g’s of +acceleration." +"He found that after only five seconds, the blood flow to the pilots’ eyes +diminished, so that their peripheral vision dimmed, creating the image +of a long tunnel. This could explain the tunnel that is often seen by +people having a near-death experience. If the periphery of your vision +blacks out, all you see is the narrow tunnel in front of you. But because +Dr. Lampert could carefully adjust the velocity of the centrifuge by +turning a dial, he found he could keep the pilots in this state indefinitely, +allowing him to prove that this tunnel vision is caused by loss of blood +flow to the periphery of the eye. + + CAN CONSCIOUSNESS LEAVE YOUR BODY? + +Some scientists who have investigated near-death and out-of-body +experiences are convinced that they are by-products of the brain itself +when it is placed under stressful conditions and its wiring gets confused. +However, there are other scientists who believe that one day, when our" +"technology is sufficiently advanced decades from now, one’s +consciousness may truly be able to leave the body. Several controversial +methods have been suggested." +"One method has been pioneered by futurist and inventor Dr. Ray +Kurzweil, who believes that consciousness may one day be uploaded into +a supercomputer. We once spoke at a conference together, and he told +me his fascination with computers and artificial intelligence began when +he was five years old and his parents bought him all sorts of mechanical +devices and toys. He loved to tinker with these devices, and even as a +child he knew he was destined to become an inventor. At MIT, he +received his doctorate under Dr. Marvin Minsky, one of the founders of +AI. Afterward, he cut his teeth applying pattern-recognition technology +to musical instruments and text-to-sound machines. He was able to +translate AI research in these areas into a string of companies. (He sold +his first company when he was only twenty.) His optical reader, which +could recognize text and convert it into sound, was heralded as an aid +for the blind, and was even mentioned by Walter Cronkite on the +evening news." +"In order to be a successful inventor, he said to me, you always have to +be ahead of the curve, to anticipate change, not react to it. Indeed, Dr. +Kurzweil loves to make predictions, and many of them have mirrored +the remarkable exponential growth of digital technology. He made the +following predictions: + +• By 2019, a $1,000 PC will have the computing power of the human +brain—twenty million billion calculations per second. (This number +is obtained by taking the one hundred billion neurons of the brain, +multiplying one thousand connections per neuron, and two hundred +calculations per second per connection.) + +• By 2029, a $1,000 PC will be a thousand times more powerful than +the human brain; the human brain itself will be successfully +reversed engineered. + +• By 2055, $1,000 of computing power will equal the processing + + power of all the humans on the planet. (He adds modestly, “I may +be off by a year or two.”)" +"power of all the humans on the planet. (He adds modestly, “I may +be off by a year or two.”) + +In particular, the year 2045 looms as an important one for Dr. +Kurzweil, since that is when he believes the “singularity” will take hold. +By then, he claims, machines will have surpassed humans in intelligence +and in fact will have created next-generation robots even smarter than +themselves. Since this process can continue indefinitely, it means, +according to Dr. Kurzweil, a never-ending acceleration of the power of +machines. In this scenario, we should either merge with our creations or +step out of their way. (Although these dates are in the far future, he told +me that he wants to live long enough to see the day when humans +finally become immortal; that is, he wants to live long enough to live +forever.)" +"As we know from Moore’s law, at a certain point computer power can +no longer advance by creating smaller and smaller transistors. In +Kurzweil’s opinion, the only way to expand computing power further +would be to increase overall size, which would leave robots scavenging +for more computer power by devouring the minerals of the Earth. Once +the planet has become a gigantic computer, robots may be forced to go +into outer space, searching for more sources of computer power. +Eventually, they may consume the power of entire stars. + +I once asked him if this cosmic growth of computers could alter the +cosmos itself. Yes, he replied. He told me that he sometimes looks at the +night sky, wondering if on some distant planet intelligent beings have +already attained the singularity. If so, then perhaps they should leave +some mark on the stars themselves that might be visible to the naked +eye." +"One limitation he told me, is the speed of light. Unless these machines +can break the light barrier, this exponential rise in power may hit a +ceiling. When that happens, says Kurzweil, perhaps they will alter the +laws of physics themselves. + +Anyone who makes predictions with such precision and scope +naturally invites criticism like a lightning rod, but it doesn’t seem to faze +him. People can quibble about this or that prediction, since Kurzweil has +missed some of his deadlines, but he is mainly concerned about the +thrust of his ideas, which predict the exponential growth of technology. +To be fair, most people working in the field of AI whom I have +interviewed agree that some form of a singularity will happen, but they +disagree sharply on when it might occur and how it will unfold. For" +"example, Bill Gates, cofounder of Microsoft, believes that no one alive +today will live to see the day when computers are smart enough to pass +for a human. Kevin Kelly, an editor for Wired magazine, has said, +“People who predict a very utopian future always predict that it is going +to happen before they die.” + +Indeed, one of Kurzweil’s many goals is to bring his father back to life. +Or rather, he wants to create a realistic simulation. There are several +possibilities, but all are still highly speculative. + +Kurzweil proposes that perhaps DNA can be extracted from his father +(from his grave site, relatives, or organic materials he left behind). +Contained within roughly twenty-three thousand genes would be a +complete blueprint to re-create the body of that individual. Then a clone +could be grown from the DNA." +"This is certainly a possibility. I once asked Dr. Robert Lanza of the +company Advanced Cell Technology how he was able to bring a long- +dead creature “back to life,” making history in the process. He told me +that the San Diego Zoo asked him to create a clone of a banteng, an +oxlike creature that had died out about twenty-five years earlier. The +hard part was extracting a usable cell for the purpose of cloning. +However, he was successful, and then he FedExed the cell to a farm, +where it was implanted into a female cow, which then gave birth to this +animal. Although no primate has ever been cloned, let alone a human, +Lanza feels it’s a technical problem, and that it’s only a matter of time +before someone clones a human." +"This would be the easy part, though. The clone would be genetically +equivalent to the original, but without its memories. Artificial memories +might be uploaded to the brain using the pioneering methods described +in Chapter 5, such as inserting probes into the hippocampus or creating +an artificial hippocampus, but Kurzweil’s father has long passed, so it’s +impossible to make the recording in the first place. The best one can do +is to assemble piecemeal all historical data about that person, such as by +interviewing others who possess relevant memories, or accessing their +credit card transactions, etc., and then inputting them into the program. + +A more practical way of inserting a person’s personality and memory +would be to create a large data file containing all known information +about a person’s habits and life. For example, today it is possible to store +all your e-mail, credit card transactions, records, schedules, electronic" +"diaries, and life history onto a single file, which can create a remarkably +accurate picture of who you are. This file would represent your entire +“digital signature,” representing everything that is known about you. It +would be remarkably accurate and intimate, detailing what wines you +like, how you spend vacations, what kind of soap you use, your favorite + + singer, and so on." +"Also, with a questionnaire, it would be possible to create a rough +approximation of Kurzweil’s father’s personality. His friends, relatives, +and associates would fill out a questionnaire containing scores of +questions about his personality, such as whether he was shy, curious, +honest, hardworking, etc. Then they would assign a number to each trait +(e.g., a “10” would mean that you are very honest). This would create a +string of hundreds of numbers, each one ranking a specific personality +trait. Once this vast set of numbers was compiled, a computer program +would take these data and approximate how he would behave in +hypothetical situations. Let’s say that you are giving a speech and are +confronted with an especially obnoxious heckler. The computer program +would then scan the numbers and then predict one of several possible +outcomes (e.g., ignore the heckler, heckle back, or get into a brawl with +the heckler). In other words, his basic personality would be reduced to a" +"the heckler). In other words, his basic personality would be reduced to a +long string of numbers, each from 1 to 10, which can be used by a +computer to predict how he would react to new situations." +"The result would be a vast computer program that would respond to +new situations roughly the way the original person would have, using +the same verbal expressions and having the same quirks, all tempered +with the memories of that person. + +Another possibility would be to forgo the whole cloning process and +simply create a robot resembling the original person. It would then be +straightforward to insert this program into a mechanical device that +looks like you, talks with the same accent and mannerisms, and moves +its arms and limbs the same way that you do. Adding your favorite +expressions (e.g., “you know ...”) would also be easy. + +Of course, today it would be easy to detect that this robot is a fake. +However, in the coming decades, it may be possible to get closer and +closer to the original, so it might be good enough to fool some people. + +But this raises a philosophical question. Is this “person” really the +same as the original? The original is still dead, so the clone or robot is," +"strictly speaking, still an impostor. A tape recorder, for example, might +reproduce a conversation we have with perfect fidelity, but that tape +recorder is certainly not the original. Can a clone or robot that behaves +just like the original be a valid substitute? + +IMMORTALITY + + These methods have been criticized because this process does not +realistically input your true personality and memories. A more faithful +way of putting a mind into a machine is via the Connectome Project, +which we discussed in the last chapter and which seeks to duplicate, +neuron for neuron, all the cellular pathways of your brain. All your +memories and personality quirks are already embedded in the +connectome." +"The Connectome Project’s Dr. Sebastian Seung notes that some people +pay $100,000 or more to have their brains frozen in liquid nitrogen. +Certain animals, like fish and frogs, can be frozen solid in a block of ice +in winter yet be perfectly healthy after thawing out in spring. This is +because they use glucose as an antifreeze to alter the freezing point of +water in their blood. Thus their blood remains liquid, even though they +are encased in solid ice. This high concentration of glucose in the human +body, however, would probably be fatal, so freezing the human brain in +liquid nitrogen is a dubious pursuit because expanding ice crystals would +rupture the cell wall from the inside (and also, as brain cells die, calcium +ions rush in, causing the brain cells to expand until they finally rupture). +In either case, brain cells would most likely not survive the freezing +process." +"Rather than freezing the body and having the cells rupture, a more +reliable process to attain immortality might be to have your connectome +completed. In this scenario, your doctor would have all your neural +connections on a hard drive. Basically, your soul would now be on a +disk, reduced to information. Then at a future point, someone would be +able to resurrect your connectome and, in principle, use either a clone or +a tangle of transistors to bring you back to life. + +The Connectome Project, as we mentioned, is still far from being able +to record a human’s neural connections. But as Dr. Seung says, “Should + +we ridicule the modern seekers of immortality, calling them fools? Or +will they someday chuckle over our graves?” + +MENTAL ILLNESS AND IMMORTALITY" +"MENTAL ILLNESS AND IMMORTALITY + +Immortality may have its drawbacks, however. The electronic brains +being built so far contain only the connections between the cortex and +the thalamus. The reverse-engineered brain, lacking a body, might begin +to suffer from sensory isolation and even manifest signs of mental illness, +as prisoners do when they are placed into solitary confinement. Perhaps +the price of creating an immortal, reverse-engineered brain is madness." +"Subjects who are placed in isolation chambers, where they are +deprived of any contact with the outside world, eventually hallucinate. +In 2008, BBC-TV aired a science program titled Total Isolation, in which +they followed six volunteers as they were placed inside a nuclear bunker, +alone and in complete darkness. After just two days, three of the +volunteers began to see and hear things—snakes, cars, zebras, and +oysters. After they were released, doctors found that all of them suffered +from mental deterioration. One subject’s memory suffered a 36 percent +drop. One can imagine that, after a few weeks or months of this, most of +them might go insane." +"To maintain the sanity of a reverse-engineered brain, it might be +essential to connect it to sensors that receive signals from the +environment so it would be able to see and feel sensations from the +outside world. But then another problem arises: it might feel that it is a +grotesque freak, an unwieldy scientific guinea pig living at the mercy of +a science experiment. Because this brain has the same memory and +personality as the original human, it would crave human contact. And +yet, lurking inside the memory of some supercomputer, with a macabre +jungle of electrodes dangling outside, the reverse-engineered brain +would be repulsive to any human. Bonding with it would be impossible. +Its friends would turn away. + +THE CAVEMAN PRINCIPLE + +At this point, what I call the Caveman Principle starts to kick in. Why do + +so many reasonable predictions fail? And why would someone not want +to live forever inside a computer?" +"The Caveman Principle is this: given a choice between high-tech or +high-touch, we opt for high-touch every time. For example, if we are +given a choice between tickets to see our favorite musician live or a CD +of the same musician in concert, which would we choose? Or if we are +given a choice between tickets to visit the Taj Mahal or just seeing a +beautiful picture of it, which would we prefer? More than likely the live +concert and the airplane tickets. + +This is because we have inherited the consciousness of our apelike +ancestors. Some of our basic personality has probably not changed much +in the last one hundred thousand years, since the first modern humans +emerged in Africa. A large portion of our consciousness is devoted to +looking good and trying to impress members of the opposite sex and our +peers. This is hardwired into our brains. + + More likely, given our basic, apelike consciousness, we will merge +with computers only if this enhances but does not totally replace our +present-day body." +"The Caveman Principle probably explains why some reasonable +predictions about the future never materialized, such as “the paperless +office.” Computers were supposed to banish paper from the office; +ironically, computers have actually created even more paper. This is +because we are descended from hunters who need “proof of the kill” +(i.e., we trust concrete evidence, not ephemeral electrons dancing on a +computer screen that vanish when you turn it off). Likewise, the +“peopleless city,” where people would use virtual reality to go to +meetings instead of commuting, never materialized. Commuting to cities +is worse than ever. Why? Because we are social animals who like to +bond with others. Videoconferencing, although useful, cannot pick up +the full spectrum of subtle information offered via body language. A +boss, for example, may want to ferret out problems in his staff and +therefore wants to see them squirm and sweat under interrogation. You +can do this only in person. + +CAVEMEN AND NEUROSCIENCE" +"CAVEMEN AND NEUROSCIENCE + +When I was a child, I read Isaac Asimov’s Foundation Trilogy and was +deeply influenced by it. First, it forced me to ask a simple question: +What will technology look like fifty thousand years in the future, when +we have a galactic empire? I also couldn’t help wondering throughout +the novel, Why do humans look and act the same as they do now? I +thought that surely thousands of years into the future humans should +have cyborg bodies with superhuman abilities. They should have given +up their puny human forms millennia ago." +"I came up with two answers. First, Asimov wanted to appeal to a +young audience willing to buy his book, so he had to create characters +that those people could identify with, including all their faults. Second, +perhaps people in the future will have the option to have superpowered +bodies but prefer to look normal most of the time. This would be +because their minds have not changed since humans first emerged from +the forest, and so acceptance from their peers and the opposite sex still +determines what they look like and what they want out of life. + +So now let us apply the Caveman Principle to the neuroscience of the +future. At the minimum, it means that any modification of the basic +human form would have to be nearly invisible on the outside. We don’t +want to resemble a refugee from a science-fiction movie, with electrodes +dangling from our head. Brain implants that might insert memories or +increase our intelligence will be adopted only if nanotechnology can" +"make microscopic sensors and probes that are invisible to the naked eye. +In the future, it might be possible to make nanofibers, perhaps made of +carbon nanotubes one molecule thick, so thin that they would be able to +make contact with neurons with surgical precision and yet leave our +appearance unaltered, with our mental capabilities enhanced. + +Meanwhile, if we need to be connected to a supercomputer to upload +information, we won’t want to be tied to a cable jacked into our spinal +cord, as in The Matrix. The connection will have to be wireless so we can +access vast amounts of computer power simply by mentally locating the +nearest server. + +Today we have cochlear implants and artificial retinas that can give +the gift of sound and sight to patients, but in the future our senses will +be enhanced using nanotechnology while we preserve our basic human +form. For instance, we might have the option of enhancing our muscles, +via genetic modification or exoskeletons. There could be a human body" +"shop from which we could order new spare parts as the old ones wear +out, but these and other physical enhancements of the body would have +to avoid abandoning the human form. + +Another way to use this technology in accordance with the Caveman +Principle is to use it as an option, rather than a permanent way of life. +One might want the option of plugging into this technology and then +unplugging soon afterward. Scientists may want to boost their +intelligence to solve a particularly tricky problem. But afterward, they +will be able to take off their helmets or implants and go about their +business. In this way, we are not caught looking like a space cadet to our +friends. The point is that no one would force you to do any of this. We +would want the option of enjoying the benefits of this technology +without the downside of looking silly." +"So in the centuries to come, it is likely our bodies will look very +similar to the ones we possess today, except that they will be perfect and +have enhanced powers. It is a relic of our apelike past that our +consciousness is dominated by ancient desires and wishes. + +But what about immortality? As we have seen, a reverse-engineered +brain, with all the personality quirks of the original person, would +eventually go mad if placed inside a computer. Furthermore, connecting +this brain to external sensors so it could feel sensations from its +environment would create a grotesque monstrosity. One partial solution +to this problem is to connect the reverse-engineered brain to an +exoskeleton. If the exoskeleton acts like a surrogate, then the reverse- +engineered brain would be able to enjoy sensations such as touch and +sight without looking grotesque. Eventually the exoskeleton would go" +"wireless, so that it would act like a human but be controlled by a +reverse-engineered brain “living” inside a computer. + +This surrogate would have the best of both worlds. Being an +exoskeleton, it would be perfect. It would possess superpowers. Since it +would be wirelessly connected to a reverse-engineered brain inside a +large computer, it would also be immortal. And lastly, since it would +sense the environment and look appealingly like a real human, it would +not have as many problems interacting with humans, many of whom +will also have probably opted for this procedure. So the actual +connectome would reside in a stationary supercomputer, although its +consciousness would manifest itself in a perfect, mobile surrogate body. + +All this would require a level of technology far beyond anything that +is attainable today. However, given the rapid pace of scientific progress, +this could become a reality by the end of the century. + +GRADUAL TRANSFERENCE" +"GRADUAL TRANSFERENCE + +Right now the process of reverse engineering involves transferring the +information within the brain, neuron for neuron. The brain has to be cut +up into thin slices, since MRI scans are not yet refined enough to identify +the precise neural architecture of the living brain. So until that can be +done, the obvious disadvantage of this approach is that you have to die +before you can be reversed engineered. Since the brain degenerates +rapidly after death, its preservation would have to take place +immediately, which is very difficult to accomplish." +"But there may be one way to attain immortality without having to die +first. This idea was pioneered by Dr. Hans Moravec, former director of +the Artificial Intelligence Laboratory at Carnegie Mellon University. +When I interviewed him, he told me that he envisions a time in the +distant future when we will be able to reverse engineer the brain for a +specific purpose: to transfer the mind into an immortal robotic body +even while a person is still conscious. If we can reverse engineer every +neuron of the brain, why not create a copy made of transistors, +duplicating precisely the thought processes of the mind? In this way, you +do not have to die in order to live forever. You can be conscious +throughout the entire process." +"He told me that this process would have to be done in steps. First, you +lie on a stretcher, next to a robot lacking a brain. Next, a robotic surgeon +extracts a few neurons from your brain, and then duplicates these +neurons with some transistors located in the robot. Wires connect your +brain to the transistors in the robot’s empty head. The neurons are then + + thrown away and replaced by the transistor circuit. Since your brain +remains connected to these transistors via wires, it functions normally +and you are fully conscious during this process. Then the super surgeon +removes more and more neurons from your brain, each time duplicating +these neurons with transistors in the robot. Midway through the +operation, half of your brain is empty; the other half is connected by + +wires to a large collection of transistors inside the robot’s head. +Eventually all the neurons in your brain have been removed, leaving a +robot brain that is an exact duplicate of your original brain, neuron for +neuron." +"At the end of this process, however, you rise from the stretcher and +find that your body is perfectly formed. You are handsome and beautiful +beyond your dreams, with superhuman powers and abilities. As a perk, +you are also immortal. You gaze back at your original mortal body, +which is just an aging shell without a mind. + +This technology, of course, is far ahead of our time. We cannot reverse +engineer the human brain, let alone make a carbon copy made of +transistors. (One of the main criticisms of this approach is that a +transistorized brain may not fit inside the skull. In fact, given the size of +electronic components, the transistorized brain may be the size of a huge +supercomputer. In this sense, this proposal begins to resemble the +previous one, in which the reverse-engineered brain is stored in a huge +supercomputer, which in turn controls a surrogate. But the great +advantage of this approach is that you don’t have to die; you’d be fully +conscious during the process.)" +"One’s head spins contemplating these possibilities. All of them seem to +be consistent with the laws of physics, but the technological barriers to +achieving them are truly formidable. All these proposals for uploading +consciousness into a computer require a technology that is far into the +future. + +But there is one last proposal for attaining immortality that does not +require reverse engineering the brain at all. It requires simply a +microscopic “nanobot” that can manipulate individual atoms. So why +not live forever in your own natural body, but with a periodic “tune-up” +that makes it immortal? + +WHAT IS AGING? + +This new approach incorporates the latest research into the aging +process. Traditionally there has been no consensus among biologists + + about the source of the aging process. But within the last decade, a new +theory has gained gradual acceptance and has unified many strands of" +"research into aging. Basically, aging is the buildup of errors, at the +genetic and cellular level. As cells get older, errors begin to build up in +their DNA and cellular debris also starts to accumulate, which makes +cells sluggish. As cells begin to slowly malfunction, skin begins to sag, +bones become frail, hair falls out, and our immune system deteriorates. +Eventually, we die. + +But cells also have error-correcting mechanisms. Over time, however, +even these error-correcting mechanisms begin to fail, and aging +accelerates. The goal, therefore, is to strengthen the natural cell-repair +mechanisms, which can be done via gene therapy and the creation of +new enzymes. But there is also another way: using “nanobot” +assemblers." +"One of the linchpins of this futuristic technology is something called +the “nanobot,” or an atomic machine, which patrols the bloodstream, +zapping cancer cells, repairing the damage from the aging process, and +keeping us forever young and healthy. Nature has already created some +nanobots, in the form of immune cells that patrol the body in the blood. +But these immune cells attack viruses and foreign bodies, not the aging +process. + +Immortality is within reach if these nanobots can reverse the ravages +of the aging process at the molecular and cellular level. In this vision, +nanobots are like immune cells, tiny police patrolling your bloodstream. +They attack any cancer cells, neutralize viruses, and clean out the debris +and mutations. Then the possibility of immortality would be within +reach using our own bodies, not some robot or clone. + +NANOBOTS—REAL OR FANTASY?" +"NANOBOTS—REAL OR FANTASY? + +My own personal philosophy is that if something is consistent with the +laws of physics, then it becomes an engineering and economics problem +to build it. The engineering and economic hurdles may be formidable, of +course, making it impractical for the present, but nonetheless it is still +possible. + +On the surface, the nanobot is simple: an atomic machine with arms +and clippers that grabs molecules, cuts them at specific points, and then +splices them back together. By cutting and pasting various atoms, the" +"nanobot can create almost any known molecule, like a magician pulling +something out of a hat. It can also self-reproduce, so it is necessary to +build only one nanobot. This nanobot will then take raw materials, +digest them, and create millions of other nanobots. This could trigger a +second Industrial Revolution, as the cost of building materials plummets. +One day, perhaps every home will have its own personal molecular +assembler, so you can have anything you want just by asking for it." +"But the key question is: Are nanobots consistent with the laws of +physics? Back in 2001, two visionaries practically came to blows over +this crucial question. At stake was nothing less than a vision of the entire +future of technology. On one side was the late Richard Smalley, a Nobel +laureate in chemistry and skeptical of nanobots. On the other side was +Eric Drexler, one of the founding fathers of nanotechnology. Their +titanic, tit-for-tat battle played out in the pages of several scientific +magazines from 2001 to 2003." +"Smalley said that, at the atomic scale, new quantum forces emerge +that make nanobots impossible. The error made by Drexler and others, +he claimed, is that the nanobot, with its clippers and arms, cannot +function at the atomic scale. There are novel forces (e.g., the Casimir +force) that cause atoms to repel or attract one another. He called this the +“sticky, fat fingers” problem, because the fingers of the nanobot are not +like delicate, precise pliers and wrenches. Quantum forces get in the +way, so it’s like trying to weld metals together while wearing gloves that +are many inches thick. Furthermore, every time you try to weld two +pieces of metal together, these pieces are either repelled or stick to you, +so you can never grab one properly." +"Drexler then fired back, stating that nanobots are not science fiction— +they actually exist. Think of the ribosomes in our own body. They are +essential in creating and molding DNA molecules. They can cut and +splice DNA molecules at specific points, which makes possible the +creation of new DNA strands. + +But Smalley wasn’t satisfied, stating that ribosomes are not all-purpose +machines that can cut and paste anything you want; they work +specifically on DNA molecules. Moreover, ribosomes are organic +chemicals that need enzymes to speed up the reaction, which occurs +only in a watery environment. Transistors are made of silicon, not water, +so these enzymes would never work, he concluded. Drexel, in turn, + +mentioned that catalysts can work even without water. This heated +exchange went back and forth through several rounds. In the end, like +two evenly matched prizefighters, both sides seemed exhausted. Drexler +had to admit that the analogy to workers with cutters and blowtorches" +"was too simplistic, that quantum forces do get in the way sometimes. But +Smalley had to concede that he was unable to score a knockout blow. +Nature had at least one way of evading the “sticky, fat fingers” problem, +with ribosomes, and perhaps there might be other subtle, unforeseen +ways as well. + +Regardless of the details of this debate, Ray Kurzweil is convinced that +these nanobots, whether or not they have fat, sticky fingers, will one day +shape not just molecules, but society itself. He summarized his vision +when he said, “I’m not planning to die.... I see it, ultimately, as an +awakening of the whole universe. I think the whole universe right now is +basically made up of dumb matter and energy and I think it will wake +up. But if it becomes transformed into this sublimely intelligent matter +and energy, I hope to be part of that.”" +"As fantastic as these speculations are, they are only a preface to the +next leap in speculation. Perhaps one day the mind will not only be free +of its material body, it will also be able to explore the universe as a +being of pure energy. The idea that consciousness will one day be free to +roam among the stars is the ultimate dream. As incredible as it may +sound, this is well within the laws of physics. + +13 THE MIND AS PURE ENERGY + +The idea that one day consciousness may spread throughout the +universe has been considered seriously by physicists. Sir Martin Rees, the +Royal Astronomer of Great Britain, has written, “Wormholes, extra +dimensions, and quantum computers open up speculative scenarios that +could transform our entire universe eventually into a ‘living cosmos’!”" +"But will the mind one day be freed of its material body to explore the +entire universe? This was the theme explored in Isaac Asimov’s classic +science-fiction tale “The Last Question.” (He would fondly recall that this +was his favorite science-fiction short story of all the ones he had +written.) In it, billions of years into the future, humans will have placed +their physical bodies in pods on an obscure planet, freeing their minds to +control pure energy throughout the galaxy. Instead of surrogates made +of steel and silicon, these surrogates are pure energy beings that can +effortlessly roam the distant reaches of space, past exploding stars, +colliding galaxies, and other wonders of the universe. But no matter how +powerful humanity has become, it is helpless as it witnesses the ultimate +death of the universe itself in the Big Freeze. In desperation, humanity +constructs a supercomputer to answer the final question: Can the death" +"constructs a supercomputer to answer the final question: Can the death +of the universe be reversed? The computer is so large and complex that +it has to be placed in hyperspace. But the computer simply responds that +there is insufficient information to give an answer." +"Eons later, as the stars begin to turn dark, all life in the universe is +about to die. But then the supercomputer finally discovers a way to +reverse the death of the universe. It collects dead stars from across the +universe, combines them into one gigantic cosmic ball, and ignites it. As +the ball explodes, the supercomputer announces, “Let there be light!” + +And there was light. + +So humanity, once freed of the physical body, is capable of playing +God and creating a new universe. + +At first, Asimov’s fantastic tale of beings made of pure energy roaming + +across the universe sounds impossible. We are accustomed to thinking of +beings made of flesh and blood, which are at the mercy of the laws of +physics and biology, living and breathing on Earth, and bound by the +gravity of our planet. The concept of conscious entities of energy, +soaring across the galaxy, unimpeded by the limitations of material +bodies, is a strange one." +"Yet this dream of exploring the universe as beings of pure energy is +well within the laws of physics. Think of the most familiar form of pure +energy, a laser beam, which is capable of containing vast amounts of +information. Today trillions of signals in the form of phone calls, data +packages, videos, and e-mail messages are transmitted routinely by fiber¬ +optic cables carrying laser beams. One day, perhaps sometime in the +next century, we will be able to transmit the consciousness of our brains +throughout the solar system by placing our entire connectomes onto +powerful laser beams. A century beyond that, we may be able to send +our connectome to the stars, riding on a light beam." +"(This is possible because the wavelength of a laser beam is +microscopic, i.e., measured in millionths of a meter. That means you can +compress vast amounts of information on its wave pattern. Think of +Morse code. The dots and dashes of Morse code can easily be +superimposed on the wave pattern of a laser beam. Even more +information can be transferred onto a beam of X-rays, which has a +wavelength even smaller than an atom.) + +One way to explore the galaxy, unbound by the messy restrictions of +ordinary matter, is to place our connectomes onto laser beams directed +at the moon, the planets, and even the stars. Given the crash program to +find the pathways of the brain, the complete connectome of the human +brain will be available late in this century, and a form of the connectome +capable of being placed on a laser beam might be available in the next +century." +"The laser beam would contain all the information necessary to +reassemble a conscious being. Although it may take years or even +centuries for the laser beam to reach its destination, from the point of +view of the person riding on the laser beam, the trip would be +instantaneous. Our consciousness is essentially frozen on the laser beam +as it soars through empty space, so the trip to the other side of the +galaxy appears to take place in the blink of an eye." +"In this way, we avoid all the unpleasant features of interplanetary and +interstellar travel. First, there is no need to build colossal booster +rockets. Instead, you simply press the “on” button of a laser. Second, +there are no powerful g forces crushing your body as you accelerate into +space. Instead, you are boosted instantly to the speed of light, since you +are immaterial. Third, you don’t have to suffer the hazards of outer +space, such as meteor impacts and deadly cosmic rays, since asteroids +and radiation pass right through you harmlessly. Fourth, you don’t have +to freeze your body or endure years of boredom as you lumber tediously +inside a conventional rocket. Instead, you zip across space at the fastest +velocity in the universe, frozen in time." +"Once we reach our destination, there would have to be a receiving +station to transfer the data of the laser beam onto a mainframe +computer, which then brings the conscious being back to life. The code +that was imprinted onto the laser beam now takes control of the +computer and redirects its programming. The connectome directs the +mainframe computer to begin simulating the future to attain its goals +(i.e., it becomes conscious). + +This conscious being inside the mainframe then sends signals +wirelessly to a robotic surrogate body, which has been waiting for us at +the destination. In this way, we suddenly “wake up” on a distant planet +or star, as if the trip took place in the blink of an eye, inside the robotic +body of our surrogate. All the complex computations take place in a +large mainframe computer, which directs the movements of a surrogate +to carry on with our business on a distant star. We are oblivious to the +hazards of space travel, as if nothing had happened." +"Now imagine a vast network of these stations spread out over the solar +system and even the galaxy. From our point of view, hopping from star +to star would be almost effortless, traveling at the speed of light in +journeys that are instantaneous. At each station, there is a robotic +surrogate waiting for us to enter its body, just like an empty hotel room +waiting for us to check in. We arrive at our destination refreshed and +equipped with a superhuman body. + +The type of surrogate robotic body that awaits us at the end of this + + journey would depend on the mission. If the job is to explore a new +world, then the surrogate body would have to work in harsh conditions. +It would have to adjust to a different gravitational field, a poisonous + +atmosphere, freezing-cold or blistering-hot temperatures, different day- +night cycles, and a constant rain of deadly radiation. To survive under +these harsh conditions, the surrogate body would have to have super +strength and super senses." +"If the surrogate body is purely for relaxation, then it would be +designed for leisurely activities. It would maximize the pleasure of +soaring through space on skis, surfboards, kites, gliders, or planes, or of +sending a ball through space propelled by the swing of a bat, club, or +racket. + +Or if the job is to mingle with and study the local natives, then the +surrogate would approximate the bodily characteristics of the indigenous +population (as in the movie Avatar )." +"Admittedly, in order to create this network of laser stations in the first +place, it might be necessary first to travel to the planets and stars in the +old-fashioned way, in more conventional rocket ships. Then one could +build the first set of these laser stations. (Perhaps the fastest, cheapest, +and most efficient way of creating this interstellar network would be to +send self-replicating robotic probes throughout the galaxy. Because they +can make copies of themselves, starting with one such probe, after many +generations there would be billions of such probes streaming out in all +directions, each one creating a laser station wherever it lands. We will +discuss this further in the next chapter.) + +But once the network is fully established, one can conceive of a +continual stream of conscious beings roaming the galaxy, so that at any +time crowds of people are leaving and arriving from distant parts of the +galaxy. Any laser station in the network might look like Grand Central +Station." +"As futuristic as this may sound, the basic physics for this concept are +already well established. This includes placing vast amounts of data onto +laser beams, sending this information across thousands of miles, and +then decoding the information at the other end. The major problems +facing this idea are therefore not in the physics, but in the engineering. +Because of this, it may take us until the next century to send our entire +connectome on laser beams powerful enough to reach the planets. It +might take us still another century to beam our minds to the stars. + +To see if this is feasible, it is instructive to do a few simple, back-of- +the-envelope calculations. The first problem is that the photons inside a" +"pencil-thin laser beam, although they appear to be in perfectly parallel +formation, actually diverge slightly in space. (When I was a child, I used +to shine a flashlight at the moon and wonder if the light ever reached it. +The answer is yes. The atmosphere absorbs over 90 percent of the +original beam, leaving some remaining to reach the moon. But the real +problem is that the image the flashlight finally casts on the moon is +miles across. This is because of the uncertainty principle; even laser +beams must diverge slowly. Since you cannot know the precise location +of the laser beam, it must, by the laws of quantum physics, slowly spread +out over time.)" +"But beaming our connectomes to the moon does not give us much +advantage, since it’s easier simply to remain on Earth and control the +lunar surrogate directly by radio. The delay is only about a second when +issuing commands to the surrogate. The real advantage comes when +controlling surrogates on the planets, since a radio message may take +hours to reach a surrogate there. The process of issuing a series of radio +commands to a surrogate, waiting for a response, and issuing another +command would be painfully slow, taking days on end. + +If you want to send a laser beam to the planets, you first have to +establish a battery of lasers on the moon, well above the atmosphere, so +there is no air to absorb the signal. Shot from the moon, a laser beam to +the planets could arrive in a matter of minutes to a few hours. Once the +laser beam has sent the connectome to the planets, then it’s possible to +directly control the surrogate without any delay factors at all." +"So establishing a network of these laser stations throughout the solar +system could be accomplished by the next century. But the problems are +magnified when we try sending the beam to the stars. This means that +we must have relay stations placed on asteroids and space stations along +the way, in order to amplify the signal, reduce errors, and send the +message to the next relay station. This could potentially be done by +using the comets that lie between our sun and the nearby stars. For +example, extending about a light-year from the sun (or one-quarter of +the distance to the nearest star) is the Oort cloud of comets. It is a +spherical shell of billions of comets, many of which lie motionless in +empty space. There is probably a similar Oort cloud of comets +surrounding the Centauri star system, which is our nearest stellar +neighbor. Assuming that this Oort cloud also extends a light-year from" +"those stars, then fully half the distance from our solar system to the next +contains stationary comets on which we can build laser relay stations. + + Another problem is the sheer amount of data that must be sent by +laser beam. The total information contained in one’s connectome, +according to Dr. Sebastian Seung, is roughly one zettabyte (that is, a 1 +with twenty-one zeros after it). This is roughly equivalent to the total +information contained in the World Wide Web today. Now consider +shooting a battery of laser beams into space carrying this vast mountain +of information. Optical fibers can carry terabytes of data per second (a 1 +with twelve zeros after it). Within the next century, advances in +information storage, data compression, and bundling of laser beams may +increase this efficiency by a factor of a million. This means that it would +take a few hours or so to send the beam into space carrying all the +information contained within the brain." +"So the problem is not the sheer amount of data sent on laser beams. In +principle, laser beams can carry an unlimited amount of data. The real +bottlenecks are the receiving stations at either end, which must have +switches that rapidly manipulate this amount of data at blinding speed. +Silicon transistors may not be fast enough to handle this volume of data. +Instead, we might have to use quantum computers, which compute not +on silicon transistors but on individual atoms. At present, quantum +computers are at a primitive level, but by the next century they might be +powerful enough to handle zettabytes of information. + +FLOATING BEINGS OF ENERGY" +"FLOATING BEINGS OF ENERGY + +Another advantage of using quantum computers to process this +mountain of data is the chance to create beings of energy that can hover +and float in the air, which appear frequently in science fiction and +fantasy. These beings would represent consciousness in its purest form. +At first, however, they may seem to violate the laws of physics, since +light always travels at the speed of light. + +But in the last decade, headlines were made by physicists at Harvard +University who announced that they were able to stop a beam of light +dead in its tracks. These physicists apparently accomplished the +impossible, slowing down a light beam to a leisurely pace until it could" +"be placed in a bottle. Capturing a light beam in a bottle is not so +fantastic if you look carefully at a glass of water. As a light beam enters +the water, it slows down, bending as it enters the water at an angle. +Similarly, light bends as it enters glass, making telescopes and +microscopes possible. The reason for all this comes from the quantum +theory. + +Think of the old Pony Express, which delivered the mail in the" +"Think of the old Pony Express, which delivered the mail in the + + nineteenth century in the American West. Each pony could sprint +between relay stations at great speed. But the bottleneck was the delay +factor at each relay station, where the mail, rider, and pony had to be +exchanged. This slowed down the average velocity of the mail +considerably. In the same way, in the vacuum between atoms, light still +travels at c, the speed of light, which is roughly 186,282 miles per second. +However, when it hits atoms, light is delayed; it is briefly absorbed and +then reemitted by atoms, sending it on its way a fraction of a second +later. This slight delay is responsible for light beams, on average, +apparently slowing down in glass or water." +"The Harvard scientists exploited this phenomenon, taking a container +of gas and carefully cooling it down to near absolute zero. At these +freezing temperatures, the gas atoms absorbed a light beam for longer +and longer time periods before reemitting it. Thus, by increasing this +delay factor, they could slow down the light beam until it came to rest. +The light beam still traveled at the speed of light between the gas atoms, +but it spent an increasing amount of time being absorbed by them. + +This raises the possibility that a conscious being, instead of assuming +control of a surrogate, may prefer to remain in the form of pure energy +and roam, almost ghostlike, as pure energy." +"So in the future, as laser beams are sent to the stars containing our +connectomes, the beam may be transferred into a cloud of gas molecules +and then contained in a bottle. This “bottle of light” is very similar to a +quantum computer. Both of them have a collection of atoms vibrating in +unison, in which the atoms are in phase with one another. And both of +them can do complex computations that are far beyond an ordinary +computer’s capability. So if the problems of quantum computers can be +solved, it may also give us the ability to manipulate these “bottles of +light.” + +FASTER THAN LIGHT? + +We see, then, that all these problems are ones of engineering. There is no +law of physics preventing traveling on an energy beam in the next +century or beyond. So this is perhaps the most convenient way of +visiting the planets and stars. Instead of riding on a light beam, as the +poets dreamed, we become the light beam." +"To truly realize the vision expressed in Asimov’s science-fiction tale, +we need to ask if faster-than-light intergalactic travel is truly possible. In +his short story, beings of immense power move freely between galaxies +separated by millions of light-years. + + Is this possible? To answer this question, we have to push the very +boundaries of modern quantum physics. Ultimately, things called +“wormholes” may provide a shortcut through the vastness of space and +time. And beings made of pure energy rather than matter would have a +decisive advantage in passing through them." +"Einstein, in some sense, is like the cop on the block, stating that you +cannot go faster than light, the ultimate velocity in the universe. +Traveling across the Milky Way galaxy, for example, would take one +hundred thousand years, even sailing on a laser beam. Although only an +instant of time has passed for the traveler, the time on the home planet +has progressed one hundred thousand years. And passing between +galaxies involves millions to billions of light-years. + +But Einstein himself left a loophole in his work. In his general theory +of relativity of 1915, he showed that gravity arose from the warping of +space-time. Gravity is not the “pull” of a mysterious invisible force, as +Newton once thought, but actually a “push” caused by space itself +bending around an object. Not only did this brilliantly explain the +bending of starlight passing near stars and the expansion of the universe, +it left open the possibility of the fabric of space-time stretching until it +ripped." +"In 1935, Einstein and his student Nathan Rosen introduced the +possibility that two black-hole solutions could be joined back to back, +like Siamese twins, so if you fell into one black hole, you could, in +principle, pass out of the other one. (Imagine joining two funnels at their +ends. Water that drains through one funnel emerges from the other.) +This “wormhole,” also called the Einstein-Rosen Bridge, introduced the + +possibility of portals or gateways between universes. Einstein himself +dismissed the possibility that you could pass through a black hole, since +you would be crushed in the process, but several subsequent +developments have raised the possibility of faster-than-light travel +through a wormhole." +"First, in 1963, mathematician Roy Kerr discovered that a spinning +black hole does not collapse into a single dot, as previously thought, but +into a rotating ring, spinning so fast that centrifugal forces prevent it +from collapsing. If you fell through the ring, then you could pass into +another universe. The gravitational forces would be large, but not +infinite. This would be like Alice’s Looking Glass, where you could pass +your hand through the mirror and enter a parallel universe. The rim of +the Looking Glass would be the ring forming the black hole itself. Since +Kerr’s discovery, scores of other solutions of Einstein’s equations have +shown that you can, in principle, pass between universes without being +immediately crushed. Since every black hole seen so far in space is + + spinning rapidly (some of them clocked at one million miles per hour), +this means that these cosmic gateways could be commonplace." +"In 1988, physicist Dr. Kip Thorne of Cal Tech and his colleagues +showed that, with enough “negative energy,” it might be possible to +stabilize a black hole so that a wormhole becomes “transversable” (i.e., +you can freely pass through it both ways without being crushed). +Negative energy is perhaps the most exotic substance in the universe, +but it actually exists and can be created (in microscopic quantities) in +the laboratory. + +So here is the new paradigm. First, an advanced civilization would +concentrate enough positive energy at a single point, comparable to a +black hole, to open up a hole through space connecting two distant +points. Second, it would amass enough negative energy to keep the +gateway open, so that it is stable and does not close the instant you enter +it." +"We can now put this idea into proper perspective. Mapping the entire +human connectome should be possible late in this century. An +interplanetary laser network could be established early in the next +century, so that consciousness can be beamed across the solar system. No +new law of physics would be required. A laser network that can go +between the stars may have to wait until the century after that. But a + +civilization that can play with wormholes will have to be thousands of +years ahead of us in technology, stretching the boundaries of known +physics." +"All this, then, has direct implications for whether consciousness can +pass between universes. If matter comes close to a black hole, the gravity +becomes so intense that your body becomes “spaghettified.” The gravity +pulling on your leg is greater than the gravity pulling on your head, so +your body is stretched by tidal forces. In fact, as you approach the black +hole, even the atoms of your body are stretched until the electrons are +ripped from the nuclei, causing your atoms to disintegrate." +"(To see the power of tidal forces, just look at the tides of Earth and the +rings of Saturn. The gravity of the moon and sun exert a pull on Earth, +causing the oceans to rise several feet during high tide. And if a moon +comes too close to a giant planet like Saturn, the tidal forces will stretch +the moon and eventually tear it apart. The distance at which moons get +ripped apart by tidal forces is called the Roche limit. The rings of Saturn +lie exactly at the Roche limit, so they might have been caused by a moon +that wandered too close to the mother planet.) + +Even if we enter a spinning black hole and use negative energy to + + stabilize it, then, the gravity fields still might be so powerful that we’d +be spaghettified." +"stabilize it, then, the gravity fields still might be so powerful that we’d +be spaghettified. + +But here is where laser beams have an important advantage over +matter when passing through a wormhole. Laser light is immaterial, so it +cannot be stretched by tidal forces as it passes near a black hole. Instead, +light becomes “blue-shifted” (i.e., it gains energy and its frequency +increases). Even though the laser beam is distorted, the information +stored on it is untouched. For example, a message in Morse code carried +by a laser beam becomes compressed, but the information content +remains unchanged. Digital information is untouched by tidal forces. So +gravitational forces, which can be fatal to beings made of matter, may be +harmless to beings traveling on light beams. + +In this way, consciousness carried by a laser beam, because it is +immaterial, has a decisive advantage over matter in passing through a +wormhole." +"Laser beams have another advantage over matter when passing +through a wormhole. Some physicists have calculated that a microscopic +wormhole, perhaps the size of an atom, might be easier to create. Matter + +would not be able to pass through such a tiny wormhole. But X-ray +lasers, with a wavelength smaller than an atom, might possibly be able +to pass through without difficulty." +"Although Asimov’s brilliant short story was clearly a work of fantasy, +ironically a vast interstellar network of laser stations might already exist +within the galaxy, yet we are so primitive that we are totally unaware of +it. To a civilization thousands of years ahead of us, the technology to +digitalize their connectomes and send them to the stars would be child’s +play. In that case, it is conceivable that intelligent beings are already +zapping their consciousness across a vast network of laser beams in the +galaxy. Nothing we observe with our most advanced telescopes and +satellites prepares us to detect such an intergalactic network. + +Carl Sagan once lamented the possibility that we might live in a world +surrounded by alien civilizations and not have the technology to realize +it. + +Then the next question is: What lurks in the alien mind?" +"Then the next question is: What lurks in the alien mind? + +If we were to encounter such an advanced civilization, what kind of +consciousness might it have? One day, the destiny of the human race +may rest on answering this question. + + Sometimes I think that the surest sign that intelligent life exists +elsewhere in the universe is that none of it has tried to contact +us. + +—BILL WATTERSON + +Either intelligent life exists in outer space or it doesn’t. Either +thought is frightening. + +—ARTHUR C. CLARKE + +14 THE ALIEN MIND" +"—ARTHUR C. CLARKE + +14 THE ALIEN MIND + +In War of the Worlds by H. G. Wells, aliens from Mars attack Earth +because their home planet is dying. Armed with death rays and giant +walking machines, they quickly incinerate many cities and are on the +verge of seizing control of Earth’s major capitals. Just as the Martians +are crushing all signs of resistance and our civilization is about to be +reduced to rubble, they are mysteriously stopped cold in their tracks. +With all their advanced science and weaponry, they failed to factor in an +onslaught from the lowliest of creatures: our germs." +"That single novel created an entire genre, launching a thousand +movies like Earth vs. the Flying Saucers and Independence Day. Most +scientists cringe, however, when they see how the aliens are described. +In the movies, aliens are often depicted as creatures with some sense of +human values and emotions. Even with glowing green skin and huge +heads, they still look like us to a certain degree. They also tend to speak +perfect English. + +But, as many scientists have pointed out, we may have much more in +common with a lobster or a sea slug than we do with an alien from +space." +"As with silicon consciousness, alien consciousness will most likely +have the general features described in our space-time theory; that is, the +ability to make a model of the world and then calculate how it will +evolve in time to achieve a goal. But while robots can be programmed so +that they emotionally bond with humans and have goals compatible +with ours, alien consciousness may have neither. It’s likely to have its +own set of values and goals, independent of humanity. One can only +speculate what these might be. + +Physicist Dr. Freeman Dyson of the Institute for Advanced Study at + + Princeton was a consultant to the movie 2001 . When he finally saw the +movie, he was delighted, not because of its dazzling special effects, but +because it was the first Hollywood movie ever to present an alien" +"consciousness, with desires, goals, and intentions totally foreign to ours. +For the first time, the aliens were not simply human actors flailing +about, trying to act menacing in cheesy monster costumes. Instead, alien +consciousness was presented as something totally orthogonal to human +experience, something entirely outside our ken. + +In 2011, Stephen Hawking raised another question. The noted +cosmologist made headlines when he said that we must be prepared for +a possible alien attack. He said that if we ever encounter an alien +civilization, it will be more advanced than ours and hence will pose a +mortal threat to our very existence." +"We have only to see what happened to the Aztecs when they +encountered the bloodthirsty Hernan Cortes and his conquistadors to +imagine what might happen with such a fateful encounter. Armed with +technology that the Bronze Age Aztecs had never seen before, such as +iron swords, gunpowder, and the horse, this small band of cutthroats +was able to crush the ancient Aztec civilization in a matter of months in +1521. + +All this raises these questions: What will alien consciousness be like? +How will their thinking process and goals differ from ours? What do +they want? + +FIRST CONTACT IN THIS CENTURY + +This is not an academic question. Given the remarkable advances in +astrophysics, we may actually make contact with an alien intelligence in +the coming decades. How we respond to them could determine one of +the most pivotal events in human history. + +Several advances are making this day possible." +"Several advances are making this day possible. + +First, in 2011 the Kepler satellite, for the first time in history, gave +scientists a “census” of the Milky Way galaxy. After analyzing light from +thousands of stars, the Kepler satellite found that one in two hundred +might harbor an earthlike planet in the habitable zone. For the first time, +we can therefore calculate how many stars within the Milky Way galaxy +might be earthlike: about a billion. As we look at the distant stars, we +have genuine reason to wonder if anyone is looking back at us. + + So far, more than one thousand exoplanets have been analyzed in" +"So far, more than one thousand exoplanets have been analyzed in + +detail by earthbound telescopes. (Astronomers find them at the rate of +about two exoplanets per week.) Unfortunately, nearly all of them are +Jupiter-size planets, probably devoid of any earthlike creatures, but +there are a handful of “super earths,” rocky planets that are a few times +larger than Earth. Already, the Kepler satellite has identified about 2,500 +candidate exoplanets in space, a handful of which look very much like +Earth. These planets are at just the right distance from their mother stars +so that liquid oceans can exist. And liquid water is the “universal +solvent” that dissolves most organic chemicals like DNA and proteins." +"In 2013, NASA scientists announced their most spectacular discovery +using the Kepler satellite: two exoplanets that are near twins of Earth. +They are located 1,200 light-years away in the constellation Lyra. They +are only 60 percent and 40 percent larger than Earth. More important, +both lie within the habitable zone of their mother star, so there is a +possibility that they have liquid oceans. Of all the planets analyzed so +far, they are the closest to being mirror images of Earth. + +Furthermore, the Hubble Space Telescope has given us an estimate of +the total number of galaxies in the visible universe: one hundred billion. +Therefore, we can calculate the number of earthlike planets in the visible +universe: one billion times one hundred billion, or one hundred +quintillion earthlike planets." +"This is a truly astronomical number, so the odds of life existing in the +universe are astronomically large, especially when you consider that the +universe is 13.8 billion years old, and there has been plenty of time for +intelligent empires to rise—and perhaps fall. In fact, it would be more +miraculous if another advanced civilization did not exist. + +SETI AND ALIEN CIVILIZATIONS + +Second, radio telescope technology is becoming more sophisticated. So +far, only about one thousand stars have been closely analyzed for signs +of intelligent life, but in the coming decade this number could rise by a +factor of one million. + +Using radio telescopes to hunt for alien civilizations dates back to +1960, when astronomer Frank Drake initiated Project Ozma (after the +Queen of Oz), using the twenty-five-meter radio telescope in Green" +"Bank, West Virginia. This marked the birth of the SETI project (the +Search for Extraterrestrial Intelligence). Unfortunately, no signals from +aliens were picked up, but in 1971 NASA proposed Project Cyclops, +which was supposed to have 1,500 radio telescopes at a cost of $10 +billion. + +Not surprisingly, it never went anywhere. Congress was not amused. + +Funding did become available for a much more modest proposal: to +send a carefully coded message in 1971 to aliens in outer space. A coded +message containing 1,679 bits of information was transmitted via the +giant Arecibo radio telescope in Puerto Rico toward the Globular Cluster +Ml 3, about 25,100 light-years away. It was the world’s first cosmic +greeting card, containing relevant information about the human race. +But no reply message was received. Perhaps the aliens were not +impressed with us, or possibly the speed of light got in the way. Given +the large distances involved, the earliest date for a reply message would +be 52,174 years from now." +"Since then, some scientists have expressed misgivings about +advertising our existence to aliens in space, at least until we know their +intentions toward us. They disagree with the proponents of the METI +Project (Messaging to Extra-Terrestrial Intelligence) who actively +promote sending signals to alien civilizations in space. The reasoning +behind the METI Project is that Earth already sends vast amounts of +radio and TV signals into outer space, so a few more messages from the +METI Project will not make much difference. But the critics of METI +believe that we should not needlessly increase our chances of being +discovered by potentially hostile aliens." +"In 1995, astronomers turned to private sources to start the SETI +Institute in Mountain View, California, to centralize research and initiate +Project Phoenix, which is trying to study one thousand nearby sunlike +stars in the l,200-to-3,000-megahertz radio range. The equipment is so +sensitive that it can pick up the emissions from an airport radar system +two hundred light-years away. Since its founding, the SETI Institute has +scanned more than one thousand stars at a cost of $5 million per year, +but still no luck. + +A more novel approach is the SETI@home project, initiated by +astronomers at the University of California at Berkeley in 1999, which +uses an informal army of millions of amateur PC owners. Anyone can + +join in this historic hunt. While you are sleeping at night, your screen +saver crunches some of the data pouring in from the Arecibo radio +telescope in Puerto Rico. So far, it has signed up 5.2 million users in 234 +countries; perhaps these amateurs dream that they will be the first in" +"human history to make contact with alien life. Like Columbus’s, their +names may go down in history. The SETI @home project has grown so +rapidly that it is, in fact, the largest computer project of this type ever +undertaken. + +When I interviewed Dr. Dan Wertheimer, director of SETI@home, I +asked him how they can distinguish false messages from real ones. He +said something that surprised me. He told me that they sometimes +deliberately “seed” the data from radio telescopes with fake signals from +an imaginary intelligent civilization. If no one picks up these fake +messages, then they know that there is something wrong with their +software. The lesson here is that if your PC screen saver announces that +it has deciphered a message from an alien civilization, please do not +immediately call the police or the president of the United States. It might +be a fake message. + +ALIEN HUNTERS" +"ALIEN HUNTERS + +One colleague of mine who has dedicated his life to finding intelligent +life in outer space is Dr. Seth Shostak, director of the SETI Institute. With +his Ph.D. in physics from the California Institute of Technology, I might +have expected him to become a distinguished physics professor lecturing +to eager Ph.D. students, but instead he spends his time in an entirely +different fashion: asking for donations to the SETI Institute from wealthy +individuals, poring over possible signals from outer space, and doing a +radio show. I once asked him about the “giggle factor”—do fellow +scientists giggle when he tells them that he listens to aliens from outer +space? Not anymore, he claims. With all the new discoveries in +astronomy, the tide has turned." +"In fact, he even sticks his neck out and says flatly that we will make +contact with an alien civilization in the very near future. He has gone on +record as proclaiming that the 350-antenna Allen Telescope Array now +being built “will trip across a signal by the year 2025.” + +Isn’t that a bit risky, I asked him? What makes him so sure? One factor +working in his favor has been the explosion in the number of radio +telescopes in the last few years. Although the U.S. government does not +fund his project, the SETI Institute recently hit pay dirt when it +convinced Paul Allen (the Microsoft billionaire) to donate over $30 +million in funds to start the Allen Telescope Array at Hat Creek, +California, 290 miles north of San Francisco. It currently scans the +heavens with 42 radio telescopes, and eventually will reach up to 350. +(One problem, however, is the chronic lack of funding for these scientific +experiments. To make up for budget cuts, the Hat Creek facility is kept" +"alive through partial funding from the military.) + +One thing, he confessed to me, makes him squirm a bit, and that is +when people confuse the SETI Project with UFO hunters. The former, he +claims, is based on solid physics and astronomy, using the latest in +technology. The latter, however, base their theories on anecdotal +hearsay evidence that may or may not be based on truth. The problem is +that the mass of UFO sightings he gets in the mail are not reproducible +or testable. He urges anyone who claims to have been abducted by aliens +in a flying saucer to steal something—an alien pen or paperweight, for +example—to prove your case. Never leave a UFO empty-handed, he told +me." +"He also concludes that there is no firm evidence that aliens have +visited our planet. I then asked him whether he thought the U.S. +government was deliberately covering up evidence of an alien +encounter, as many conspiracy theorists believe. He replied, “Would +they really be so efficient at covering up a big thing like this? +Remember, this is the same government that runs the post office.” + +DRAKE’S EQUATION + +When I asked Dr. Wertheimer why he is so sure that there is alien life in +outer space, he replied that the numbers are in his favor. Back in 1961, +astronomer Frank Drake tried to estimate the number of such intelligent +civilizations by making plausible assumptions. If we start with the +number one hundred billion, the number of stars in the Milky Way +galaxy, then we can estimate the fraction of them that are similar to our" +"sun. We can reduce that number further by estimating the fraction of +them that have planets, the fraction of them that have earthlike planets, +etc. After making a number of reasonable assumptions, we come up with +an estimate of ten thousand advanced civilizations in our own Milky +Way galaxy. (Carl Sagan, with a different set of estimates, came up with +the number one million.)" +"Since then, scientists have been able to make much better estimates of +the number of advanced civilizations in our galaxy. For example, we +know there are more planets orbiting stars than Drake originally +expected, and more earthlike planets as well. But we still face a problem. +Even if we know how many earthlike twins there are in space, we still +don’t know how many of them support intelligent life. Even on Earth, it +took 4.5 billion years before intelligent beings (us) finally arose from the +swamp. For about 3.5 billion years, life-forms have existed on Earth, but +only in the last one hundred thousand years or so have intelligent beings + + like us emerged. So even on an earthlike planet like Earth itself, the rise +of truly intelligent life has been very difficult. + +WHY DON’T THEY VISIT US?" +"WHY DON’T THEY VISIT US? + +But then I asked Dr. Seth Shostak of SETI this killer question: If there are +so many stars in the galaxy, and so many alien civilizations, then why +don’t they visit us? This is the Fermi paradox, named for Enrico Fermi, +the Nobel laureate who helped build the atomic bomb and unlocked the +secrets of the nucleus of the atom. + +Many theories have been proposed. For one, the distance between +stars might be too great. It would take about seventy thousand years for +our most powerful chemical rockets to reach the stars nearest to Earth. +Perhaps a civilization thousands to millions of years more advanced than +ours may solve this problem, but there’s another possibility. Maybe they +annihilated themselves in a nuclear war. As John F. Kennedy once said, +“I am sorry to say there is too much point to the wisecrack that life is +extinct on other planets because their scientists were more advanced +than ours.”" +"But perhaps the most logical reason is this: Imagine walking down a +country road and encountering an ant hill. Do we go down to the ants + +and say, “I bring you trinkets. I bring you beads. I give you nuclear +energy. I will create an ant paradise for you. Take me to your leader”? + +Probably not. + +Now imagine that workers are building an eight-lane superhighway +next to the anthill. Would the ants know what frequency the workers are +talking on? Would they even know what an eight-lane superhighway +was? In the same fashion, any intelligent civilization that can reach +Earth from the stars would be thousands of years to millions of years +ahead of us, and we may have nothing to offer them. In other words, we +are arrogant to believe that aliens will travel trillions upon trillions of +miles just to see us. + +More than likely, we are not on their radar screen. Ironically, the +galaxy could be teaming with intelligent life-forms and we are so +primitive that we are oblivious of them. + +FIRST CONTACT" +"FIRST CONTACT + + But assume for the moment that the time will come, perhaps sooner +rather than later, when we make contact with an alien civilization. This +moment could be a turning point in the history of humanity. So the next +questions are: What do they want, and what will their consciousness be +like? + +In the movies and in science-fiction novels, the aliens often want to +eat us, conquer us, mate with us, enslave us, or strip our planet of +valuable resources. But all this is highly improbable. + +Our first contact with an alien civilization will probably not begin +with a flying saucer landing on the White House lawn. More likely, it +will happen when some teenager, running a screen saver from the +SETI@home project, announces that his or her PC has decoded signals +from the Arecibo radio telescope in Puerto Rico. Or perhaps when the +SETI project at Hat Creek detects a message that indicates intelligence." +"Our first encounter will therefore be a one-way event. We will be able +to eavesdrop on intelligent messages, but a return message may take +decades or centuries to reach them. + +The conversations that we hear on the radio may give us valuable +insight into this alien civilization. But most of the message will likely be + +gossip, entertainment, music, etc., with little scientific content. + +Then I asked Dr. Shostak the next key question: Will you keep it a +secret once First Contact is made? After all, won’t it cause mass panic, +religious hysteria, chaos, and spontaneous evacuations? I was a bit +surprised when he said no. They would give all the data to the +governments of the world and to the people. + +The next questions are: What will they be like? How do they think? + +To understand alien consciousness, perhaps it is instructive to analyze +another consciousness that is quite alien to us, the consciousness of +animals. We live with them, yet we are totally ignorant of what goes on +in their minds." +"Understanding animal consciousness, in turn, may help us understand +alien consciousness. + +ANIMAL CONSCIOUSNESS + + Do animals think? And if so, what do they think about? This question +has perplexed the greatest minds in history for thousands of years. The +Greek writers and historians Plutarch and Pliny both wrote about a +famous question that remains unsolved even today. Over the centuries, +many solutions have been given by the giants of philosophy. + +A dog is traveling down a road, looking for its master, when it +encounters a fork that branches in three directions. The dog first takes +the left path, sniffs around, and then returns, knowing that his master +has not taken that road. Then it takes the right path, sniffs, and realizes +that his master has not taken this road either. But this time, the dog +triumphantly takes the middle road, without sniffing." +"What was going on in the dog’s mind? Some of the greatest +philosophers have tackled this question, to no avail. The French +philosopher and essayist Michel de Montaigne wrote that the dog +obviously concluded that the only possible solution was to take the +middle road, a conclusion showing that dogs are capable of abstract +thought. + +But St. Thomas Aquinas, arguing in the thirteenth century, said the +opposite—that the appearance of abstract thought is not the same thing +as genuine thinking. We can be fooled by superficial appearances of + +intelligence, he claimed. + +Centuries later, there was also a famous exchange between John Locke +and George Berkeley about animal consciousness. “Beasts abstract not,” +proclaimed Locke flatly. To which Bishop Berkeley responded, “If the +fact that brutes abstract not be made the distinguishing property of that +sort of animal, I fear a great many of those that pass for man must be +reckoned into their number.”" +"Philosophers down the ages have tried to analyze this question in the +same manner: by imposing human consciousness on the dog. This is the +mistake of anthropomorphism, or assuming that animals think and +behave like us. But perhaps the real solution might be to look at this +question from the dog’s point of view, which could be quite alien. + +In Chapter 2, I gave a definition of consciousness in which animals +were part of a continuum of consciousness. Animals can differ from us in +the parameters they use to create a model of the world. Dr. David +Eagleman says that psychologists call this “umwelt,” or the reality +perceived by other animals. He notes, “In the blind and deaf world of the +tick, the important signals are temperature and the odor of butyric acid. +For the black ghost knifefish, it’s electrical fields. For the echo locating +bat, air-compressed waves. Each organism inhabits its own umwelt, + + which it presumably assumes to be the entire objective reality ‘out +there.’ ”" +"which it presumably assumes to be the entire objective reality ‘out +there.’ ” + +Consider the brain of a dog, which is constantly living in a swirl of +odors, by which it hunts for food or locates a mate. From these smells, +the dog then constructs a mental map of what exists in its surroundings. +This map of smells is totally different from the one we get from our eyes +and conveys an entirely different set of information. (Recall from +Chapter 1 that Dr. Penfield constructed a map of the cerebral cortex, +showing the distorted self-image of the body. Now imagine a Penfield +diagram of a dog’s brain. Most of it would be devoted to its nose, not its +fingers. Animals would have a totally different Penfield diagram. Aliens +in space would likely have an even stranger Penfield diagram.)" +"Unfortunately, we tend to assign human consciousness to animals, +even though animals may have a totally different world outlook. For +example, when a dog faithfully follows its master’s orders, we +subconsciously assume that the dog is man’s best friend because he likes +us and respects us. But since the dog is descended from Cards lupus (the + +gray wolf), which hunts in packs with a rigid pecking order, more than +likely the dog sees you as some sort of alpha male, or the leader of the +pack. You are, in some sense, the Top Dog. (This is probably one reason +why puppies are much easier to train than older dogs; it is likely easier +to imprint one’s presence on a puppy’s brain, while more mature dogs +realize that humans are not part of their pack.)" +"Also, when a cat enters a new room and urinates all over the carpet, +we assume that the cat is angry or nervous, and we try to find out the +reason why the cat is upset. But perhaps the cat is simply marking its +territory with the smell of its urine to ward off other cats. So the cat is +not upset at all; it’s simply warning other cats to stay out of the house, +because the house belongs to it. + +And if the cat purrs and rubs itself against your legs, we assume that it +is grateful to you for taking care of it, that this is a sign of warmth and +affection. More than likely, the cat is rubbing its hormone onto you to +claim ownership of its possession (i.e., you), to ward off other cats. In +the cat’s viewpoint, you are a servant of some sort, trained to give it +food several times a day, and rubbing its scent on you warns other cats +to stay away from this servant." +"As the sixteenth-century philosopher Michel de Montaigne once wrote, +“When I play with my cat, how do I know that she is not playing with +me rather than I with her?” + +And if the cat then stalks off to be alone, it is not necessarily a sign of +anger or aloofness. The cat is descended from the wildcat, which is a + + solitary hunter, unlike the dog. There is no alpha male to slobber over, +as in the case of the dog. The proliferation of various “animal whisperer” +programs on TV is probably a sign of the problems we encounter when +we force human consciousness and intentions onto animals." +"A bat would also have a much different consciousness, which would +be dominated by sounds. Almost blind, the bat requires constant +feedback from tiny squeaks it makes, which allow it to locate insects, +obstacles, and other bats via sonar. The Penfield map of its brain would +be quite alien to us, with a huge portion devoted to its ears. Similarly, +dolphins have a different consciousness than humans, which is also +based on sonar. Because dolphins have a smaller frontal cortex, it was +once thought that they were not so intelligent, but the dolphin +compensates for this by having a larger brain mass. If you unfold the + +neocortex of the dolphin brain, it would cover six magazine pages, while +if you unfold the neocortex of a human, it would measure only four +magazine pages. Dolphins also have very well-developed parietal and +temporal cortices to analyze sonar signals in the water and are one of +the few animals that can recognize themselves in a mirror, probably +because of this fact." +"In addition, the dolphin brain is actually structured differently from +humans’ because dolphin and human lineages diverged about ninety-five +million years ago. Dolphins have no need for a nose, so their olfactory +bulb disappears soon after birth. But thirty million years ago, their +auditory cortex exploded in size because dolphins learned to use +echolocation, or sonar, to find food. Like bats’, their world must be one +of whirling echoes and vibrations. Compared to humans, dolphins have +an extra lobe in their limbic system, called the “paralimbic” region, +which probably helps them forge strong social relations." +"Meanwhile, dolphins also have a language that is intelligent. I once +swam in a pool of dolphins for a TV special for the Science Channel. I +put sonar sensors in the pool that could pick up the clicks and whistles +used by dolphins to talk to one another. These signals were recorded and +then analyzed by computer. There is a simple way to discern if there is +an intelligence lurking among this random set of squeals and chirps. In +the English language, for example, the letter e is the most commonly +used letter of the alphabet. In fact, we can create a list of all the letters +of the alphabet and how frequently they occur. No matter what book in +English we analyze by computer, it will roughly obey the same list of +commonly found letters of the alphabet. + +Similarly, this computer program can be used to analyze the dolphins’ +language. Sure enough, we find a similar pattern indicating intelligence. +However, as we go to other mammals, the pattern begins to break down," +"and it finally collapses completely as we approach lower animals with +small brain sizes. Then the signals become nearly random. + +INTELLIGENT BEES? + +To get a sense of what alien consciousness might be like, consider the +strategies adopted by nature to reproduce life on Earth. There are two + +basic reproductive strategies nature has taken, with profound +implications for evolution and consciousness. + +The first, the strategy used by mammals, is to produce a small number +of young offspring and then carefully nurse each one to maturity. This is +a risky strategy, because only a few progeny are produced in each +generation, so it assumes that nurturing will even out the odds. This +means that every life is cherished and carefully nurtured for a length of +time." +"But there is another, much older strategy that is used by much of the +plant and animal kingdom, including insects, reptiles, and most other +life-forms on Earth. This involves creating a large number of eggs or +seeds and then letting them fend for themselves. Without nurturing, +most of the offspring never survive, so only a few hardy individuals will +make it into the next generation. This means that the energy invested in +each generation by the parents is nil, and reproduction relies on the law +of averages to propagate the species." +"These two strategies produce startlingly different attitudes toward life +and intelligence. The first strategy treasures each and every individual. +Love, nurturing, affection, and attachment are at a premium in this +group. This reproductive strategy can work only if the parents invest a +considerable amount of precious energy to preserve their young. The +second strategy, however, does not treasure the individual at all, but +rather emphasizes the survival of the species or group as a whole. To +them, individuality means nothing." +"Furthermore, reproductive strategy has profound implications for the +evolution of intelligence. When two ants meet each other, for example, +they exchange a limited amount of information using chemical scents +and gestures. Although the information shared by two ants is minimal, +with this information they are capable of creating elaborate tunnels and +chambers necessary to build an anthill. Similarly, although honeybees +communicate with one another by performing a dance, they can +collectively create complex honeycombs and locate distant flower beds. +So their intelligence arises not so much from the individual, but from the + + holistic interaction of the entire colony and from their genes. + +So consider an intelligent extraterrestrial civilization based on the +second strategy, such as an intelligent race of honeybees. In this society, +the worker bees that fly out each day in search of pollen are expendable." +"Worker bees do not reproduce at all, but instead live for one purpose, to +serve the hive and the queen, for which they willingly sacrifice +themselves. The bonds that link mammals together mean nothing to +them. + +Hypothetically, this might affect the development of their space +program. Since we treasure the life of every astronaut, considerable +resources are devoted to bringing them back alive. Much of the cost of +space travel goes into life support so the astronauts can make the return +voyage home and reenter the atmosphere. But for a civilization of +intelligent honeybees, each worker’s life may not be worth that much, so +their space program would cost considerably less. Their workers would +not have to come back. Every voyage might be a one-way trip, and that +would represent significant savings." +"Now imagine if we were to encounter an alien from space that was +actually similar to a honeybee worker. Normally, if we encounter a +honeybee in the forest, chances are it will completely ignore us, unless +we threaten it or the hive. It’s as if we did not exist. Similarly, this +worker would most likely not have the slightest interest in making +contact with us or sharing its knowledge. It would go on with its primary +mission and ignore us. Moreover, the values that we cherish would mean +little to it. + +Back in the 1970s, there were two medallions put aboard the Pioneer +10 and 11 probes, containing crucial information about our world and +society. The medallions exalted the diversity and richness of life on +Earth. Scientists back then assumed that alien civilizations in space +would be like us, curious and interested in making contact. But if such +an alien worker bee were to find our medallion, chances are that it +would mean nothing to it." +"Furthermore, each worker need not be very intelligent. They need to +be only intelligent enough to serve the interest of the hive. So if we were +to send a message to a planet of intelligent bees, chances are that they +would show little interest in sending a message back. + +Even if contact could be made with such a civilization, it might be +difficult communicating with them. For example, when we communicate +with one another, we break ideas down into sentences, with a subject- +verb structure, in order to build a narrative, often a personal story. Most + + of our sentences have the following structure: “I did this” or “They did + +that.” In fact, most of our literature and conversations use storytelling, +often involving experiences and adventures that we or our role models +have had. This presupposes that our personal experiences are the +dominant way to convey information." +"However, a civilization based on intelligent honeybees may not have +the least interest in personal narratives and storytelling. Being highly +collective, their messages may not be personal, but matter-of-fact, +containing vital information necessary for the hive rather than personal +trivia and gossip that might advance an individual’s social position. In +fact, they might find our storytelling language to be a bit repulsive, since +it puts the role of the individual before the needs of the collective. + +Also, worker bees would have a totally different sense of time. Since +worker bees are expendable, they might not have a long life span. They +might only take on projects that are short and well defined." +"However, humans live much longer, but we also have a tacit sense of +time; we take on projects and occupations that we can reasonably see to +the end within our lifetimes. We subconsciously pace our projects, our +relations with others, and our goals to accommodate a finite life span. In +other words, we live our lives in distinct phases: being single, married, +raising children, and eventually retiring. Often without being conscious +of it, we assume that we will live and eventually die within a finite time +frame." +"But imagine beings that can live for thousands of years, or are perhaps +immortal. Their priorities, their goals, and their ambitions would be +completely different. They could take on projects that would normally +require scores of human lifetimes. Interstellar travel is often dismissed as +pure science fiction because, as we have seen, the time it takes for a +conventional rocket to reach nearby stars is roughly seventy thousand +years. For us, this is prohibitively long. But for an alien life-form, that +time may be totally irrelevant. For example, they might be able to +hibernate, slow down their metabolism, or simply live for an indefinite +amount of time. + +WHAT DO THEY LOOK LIKE? + +Our first translations of these alien messages will probably give us some" +"Our first translations of these alien messages will probably give us some + + insight into the aliens’ culture and way of life. For example, it is likely +that the aliens will have evolved from predators and hence still share +some of their characteristics. (In general, predators on Earth are smarter +than prey. Hunters like tigers, lions, cats, and dogs use their cunning to +stalk, ambush, and hide, all of which require intelligence. All these +predators have eyes on the front of the face, for stereo vision as they +focus their attention. Prey, which have eyes to the sides of the face to +spot a predator, have only to run. That is why we say “sly as a fox” and +“dumb bunny.”) The alien life-forms may have outgrown many of the +predator instincts of their distant ancestors, but it is likely that they will +still have some of a predator’s consciousness (i.e., territoriality, +expansion, and violence when necessary)." +"If we examine the human race, we see that there were at least three +basic ingredients that set the stage for our becoming intelligent: + +1 . the opposable thumb, which gives us the ability to manipulate and + +reshape our environment via tools + +2. stereo eyes or the 3-D eyes of a hunter + +3. language, which allows us to accumulate knowledge, culture, and + +wisdom across generations + +When we compare these three ingredients with the traits found in the +animal kingdom, we see that very few animals meet these criteria for +intelligence. Cats and dogs, for example, do not have grasping ability or +a complex language. Octopi have sophisticated tentacles, but they don’t +see well and don’t have a complex language." +"There may be variations of these three criteria. Instead of an +opposable thumb, an alien might have claws or tentacles. (The only +prerequisite is that they should be able to manipulate their environment +with tools created by these appendages.) Instead of having two eyes, +they may have many more, like insects. Or they may have sensors that +detect sound or UV light rather than visible light. More than likely, they +will have the stereo eyes of a hunter, because predators generally have a +higher level of intelligence than prey. Also, instead of a language based +on sounds, they may communicate via different forms of vibrations. (The +only requirement is that they exchange information among themselves to + +create a culture spanning many generations.) + +But beyond these three criteria, anything goes." +"Next, the aliens may have a consciousness colored by their +environment. Astronomers now realize that the most plentiful habitat for +life in the universe may not be earthlike planets, where they can bask in +the warm sunlight of the mother star, but on icy-cold satellites orbiting +Jupiter-size planets billions of miles from the star. It is widely believed +that Europa, an ice-covered moon of Jupiter, has a liquid ocean beneath +the icy surface, heated by tidal forces. Because Europa tumbles as it +orbits Jupiter, it is squeezed in different directions by the huge +gravitational pull of Jupiter, which causes friction deep inside the moon. +This generates heat, forming volcanoes and ocean vents that melt the ice +and create liquid oceans. It is estimated that the oceans of Europa are +quite deep, and that their volume may be many times the volume of the +oceans of Earth. Since 50 percent of all stars in the heavens may have +Jupiter-size planets (a hundred times more plentiful than earthlike" +"Jupiter-size planets (a hundred times more plentiful than earthlike +planets), the most plentiful form of life may be on the icy moons of gas +giants like Jupiter." +"Therefore, when we encounter our first alien civilization in space, +more than likely it will have an aquatic origin. (Also, it is likely that +they will have migrated from the ocean and learned to live on the icy +surface of their moon away from the water, for several reasons. First, +any species that lives perpetually under the ice will have a quite limited +view of the universe. They will never develop astronomy or a space +program if they think that the universe is just the ocean underneath the +ice cover. Second, because water short-circuits electrical components, +they will never develop radio or TV if they stay underwater. If this +civilization is to advance, it must master electronics, which cannot exist +in the oceans. So, most likely, these aliens will have learned to leave the +oceans and survive on the land, as we did.)" +"But what happens if this life-form evolves to create a space-faring +civilization, capable of reaching Earth? Will they still be biological +organisms like us, or will they be post-biological? + +THE POST-BIOLOGICAL ERA + +One person who has spent considerable time thinking about these +questions is my colleague Dr. Paul Davies of Arizona State University, +near Phoenix. When I interviewed him, he told me that we have to +expand our own horizon to contemplate what a civilization that is +thousands or more years ahead of us may look like. + +Given the dangers of space travel, he believes that such beings will +have abandoned their biological form, much like the bodiless minds we +considered in the previous chapter. He writes, “My conclusion is a +startling one. I think it very likely—in fact inevitable—that biological" +"intelligence is only a transitory phenomenon, a fleeting phase in the +evolution of intelligence in the universe. If we ever encounter +extraterrestrial intelligence, I believe it is overwhelmingly likely to be +post-biological in nature, a conclusion that has obvious and far-reaching +ramifications for SETI.” + +In fact, if the aliens are thousands of years ahead of us, chances are +that they have abandoned their biological bodies eons ago to create the +most efficient computational body: a planet whose entire surface is +completely covered with computers. Dr. Davies says, “It isn’t hard to +envision the entire surface of a planet being covered with a single +integrated processing system.... Ray Bradbury has coined the term +‘Matrioshka brains’ for these awesome entities.”" +"So to Dr. Davies, alien consciousness may lose the concept of “self” +and be absorbed into the collective World Wide Web of Minds, which +blankets the entire surface of the planet. Dr. Davies adds, “A powerful +computer network with no sense of self would have an enormous +advantage over human intelligence because it could redesign ‘itself,’ +fearlessly make changes, merge with whole systems, and grow. ‘Feeling +personal’ about it would be a distinct impediment to progress.” + +So in the name of efficiency and increased computational ability, he +envisions members of this advanced civilization giving up their identity +and being absorbed into a collective consciousness. + +Dr. Davies acknowledges that critics of his idea may find this concept +rather repulsive. It appears as if this alien species is sacrificing +individuality and creativity to the greater good of the collective or the +hive. This is not inevitable, he cautions, but it is the most efficient +option for civilization." +"Dr. Davies also has a conjecture that he admits is rather depressing. + +When I asked him why these civilizations don’t visit us, he gave me a +strange answer. He said that any civilization that advanced would also +have developed virtual realities far more interesting and challenging +than reality. The virtual reality of today would be a children’s toy +compared to the virtual reality of a civilization thousands of years more +advanced than us. + +This means that perhaps their finest minds might have decided to play +out imaginary lives in different virtual worlds. It’s a discouraging +thought, he admitted, but certainly a possibility. In fact, it might even be +a warning for us as we perfect virtual reality. + + WHAT DO THEY WANT?" +"WHAT DO THEY WANT? + +In the movie The Matrix, the machines take over and put humans into +pods, where they exploit us as batteries to energize themselves. That is +why they keep us alive. But since a single electrical plant produces more +power than the bodies of millions of humans, any alien looking for an +energy source would quickly see there is no need for human batteries. +(This seems to be lost on the machine overlords in the Matrix, but +hopefully aliens would see reason.)" +"Another possibility is that they might want to eat us. This was +explored in an episode of The Twilight Zone, in which aliens land on +Earth and promise us the benefits of their advanced technology. They +even ask for volunteers to visit their beautiful home planet. The aliens +accidentally leave behind a book, called To Serve Man, which scientists +anxiously try to decipher in order to discover what wonders the aliens +will share with us. Instead, the scientists find out that the book is +actually a cookbook. (But since we will be made of entirely different +DNA and proteins from theirs, we could be difficult for their digestive +tracts to process.)" +"Another possibility is that the aliens will want to strip Earth of +resources and valuable minerals. There may be some truth to this +argument, but if the aliens are advanced enough to travel effortlessly +from the stars, then there are plenty of uninhabited planets to plunder +for resources, without having to worry about restive natives. From their +point of view, it would be a waste of time to try to colonize an inhabited + +planet when there are easy alternatives." +"planet when there are easy alternatives. + +So if the aliens do not want to enslave us or plunder our resources, +then what danger do they pose? Think of deer in a forest. Whom should +they fear the most—the ferocious hunter armed with a shotgun, or the +mild-mannered developer armed with a blueprint? Although the hunter +may scare the deer, only a few deer are threatened by him. More +dangerous to the deer is the developer, because the deer are not even on +his radar screen. The developer may not even think about the deer at all, +concentrating instead on developing the forest into usable property. In +view of this, what would an invasion actually look like?" +"In Hollywood movies, there is one glaring flaw: the aliens are only a +century or so ahead of us, so we can usually devise a secret weapon or +exploit a simple weakness in their armor to fight them off, as in Earth vs. +the Flying Saucers. But as SETI director Dr. Seth Shostak once told me, a +battle with an advanced alien civilization will be like a battle between +Bambi and Godzilla. + + In reality, the aliens might be millennia to millions of years ahead of +us in their weaponry. So, for the most part, there will be little we can do +to defend ourselves. But perhaps we can learn from the barbarians who +defeated the greatest military empire of its time, the Roman Empire. + +The Romans were masters of engineering, able to create weapons that +could flatten barbarian villages and roads to supply distant military +outposts of a vast empire. The barbarians, who were barely emerging +from a nomadic existence, had little chance when encountering the +juggernaut of the Roman Imperial Army." +"But history records that as the empire expanded, it was spread too +thin, with too many battles to fight, too many treaties bogging it down, +and not enough of an economy to support all this, especially with a +gradual decline in population. Moreover, the empire, always short on +recruits, had to enlist young barbarian soldiers and promote them to +leadership positions. Inevitably, the superior technology of the empire +began to filter down to the barbarians as well. In time, the barbarians +began to master the very military technologies that at first had +conquered them. + +Toward the end, the empire, weakened by internal palace intrigues, +severe crop shortages, civil wars, and an overstretched army, faced +barbarians who were able to fight the Roman Imperial Army to a + +standstill. The sacking of Rome in A.D. 410 and 455 paved the way for +the empire’s ultimate fall in A.D. 476." +"In the same way, it is likely that earthlings will initially offer no real +threat to an alien invasion, but over time earthlings could learn the weak +points of the alien army, its power supplies, its command centers, and +most of all its weaponry. In order to control the human population, the +aliens will have to recruit collaborators and promote them. This will +result in a diffusion of their technology to the humans. + +Then a ragtag army of earthlings might be able to mount a +counterattack. In Eastern military strategy, like the classic teachings of +Sun Tzu in The Art of War, there is a way to defeat even a superior army. +You first allow it to enter your territory. Once it has entered unfamiliar +land and its ranks are diffused, you can counterattack where they are +weakest." +"Another technique is to use the enemy’s strength against it. In judo, +the principal strategy is to turn the momentum of the attacker to your +advantage. You let the enemy attack, and then trip them or throw them +off guard, exploiting the enemy’s own mass and energy. The bigger they + + are, the harder they fall. In the same way, perhaps the only way to fight +a superior alien army is to allow it to invade your territory, learn its +weaponry and military secrets, and turn those very weapons and secrets +against it. + +So a superior alien army cannot be defeated head-on. But it will +withdraw if it cannot win and the cost of a stalemate is too high. Success +means depriving the enemy of a victory." +"But more than likely, I believe the aliens will be benevolent and, for +the most part, ignore us. We simply have nothing to offer them. If they +visit us, then it will be mainly out of curiosity or for reconnaissance. +(Since curiosity was an essential feature in our becoming intelligent, it is +likely that any alien species will be curious, and hence want to analyze +us, but not necessarily to make contact.) + +MEETING AN ALIEN ASTRONAUT + +Unlike in the movies, we will probably not meet the flesh-and-blood +alien creatures themselves. It would simply be too dangerous and + +unnecessary. In the same way that we sent the Mars Rover to explore, +aliens will more than likely send organic/mechanical surrogates or +avatars instead, which can better handle the stresses of interstellar +travel. In this way, the “aliens” we meet on the White House lawn may +look nothing like their masters back on the home planet. Instead, the +masters will project their consciousness into space through proxies." +"More than likely, though, they will send a robotic probe to our moon, +which is geologically stable, with no erosion. These probes are self- +replicating; that is, they will create a factory and manufacture, say, a +thousand copies of themselves. (These are called von Neumann probes, +after mathematician John von Neumann, who laid the foundation for +digital computers. Von Neumann was the first mathematician to +seriously consider the problem of machines that could reproduce +themselves.) These second-generation probes are then launched to other +star systems, where each one in turn creates a thousand more third- +generation probes, making a total of a million. Then these probes fan out +and create more factories, making a billion probes. Starting with just one +probe, we have one thousand, then a million, then a billion. Within five +generations, we have a quadrillion probes. Soon we have a gigantic +sphere, expanding at near light speed, containing trillions upon trillions" +"sphere, expanding at near light speed, containing trillions upon trillions +of probes, colonizing the entire galaxy within a few hundred thousand +years." +"Dr. Davies takes this idea of self-replicating von Neumann probes so +seriously that he has actually applied for funding to search the surface of +the moon for evidence of a previous alien visitation. He wishes to scan +the moon for radio emissions or radiation anomalies that would indicate +evidence of an alien visitation, perhaps millions of years ago. He wrote a +paper with Dr. Robert Wagner in the scientific journal Acta Astronautica +calling for a close examination of the photos from the Lunar +Reconnaissance Orbiter down to a resolution of about 1.5 feet." +"They wrote, “Although there is only a tiny probability that alien +technology would have left traces on the moon in the form of an artifact +or surface modification of lunar features, this location has the virtue of +being close,” and also traces of an alien technology would remain +preserved over long periods of time. Since there is no erosion on the +moon, treadmarks left by aliens would still be visible (in the same way +that footprints left by our astronauts in the 1970s could, in principle, last + +for billions of years). + +One problem is that the von Neumann probe might be very small. +Nanoprobes use molecular machines and MEMs, and hence it might be +only as big as a bread box, he said to me, or even smaller. (In fact, if +such a probe landed on Earth in someone’s backyard, the owner might +not even notice.)" +"This method, however, represents the most efficient way of colonizing +the galaxy, using the exponential growth of self-replicating von +Neumann probes. (This is also the way in which a virus infects our body. +Starting with a handful of viruses, they land on our cells, hijack the +reproductive machinery, and convert our cells into factories to create +more viruses. Within two weeks, a single virus can infect trillions of +cells, and we eventually sneeze.)" +"If this scenario is correct, it means that our own moon is the most +likely place for an alien visitation. This is also the basis of the movie +2001: A Space Odyssey, which even today represents the most plausible +encounter with an extraterrestrial civilization. In the movie, a probe was +placed on our moon millions of years ago, mainly to observe the +evolution of life on Earth. At times, it interferes in our evolution and +gives us an added boost. This information is then sent to Jupiter, which +is a relay station, before heading to the home planet of this ancient alien +civilization. + +From the point of view of this advanced civilization, which can +simultaneously scan billions of star systems, we can see that they have a +considerable choice in what planetary systems to colonize. Given the +sheer enormity of the galaxy, they can collect data and then best choose + + which planets or moons would yield the best resources. From their +perspective, they might not find Earth very appealing." +"The empires of the future will be empires of the mind. + +—WINSTON CHURCHILL + +If we continue to develop our technology without wisdom +prudence, our servant may prove to be our executioner. + +—GENERAL OMAR BRADLEY + +15 CONCLUDING REMARKS + +In 2000, a raging controversy erupted in the scientific community. +One of the founders of Sun Computers, Bill Joy, wrote an inflammatory +article denouncing the mortal threat we face from advanced technology. +In an article in Wired magazine with the provocative title “The Future +Does Not Need Us,” he wrote, “Our most powerful 21st century +technologies—robotics, genetic engineering, and nanotech—are +threatening to make humans an endangered species.” That incendiary +article questioned the very morality of hundreds of dedicated scientists +toiling in their labs on the cutting edge of science. He challenged the +very core of their research, stating that the benefits of these technologies +were vastly overshadowed by the enormous threats they posed to +humanity." +"He described a macabre dystopia in which all our technologies +conspire to destroy civilization. Three of our key creations will +eventually turn on us, he warned: + +• One day, bioengineered germs may escape from the laboratory and +wreak havoc on the world. Since you cannot recapture these life- +forms, they might proliferate wildly and unleash a fatal plague on +the planet worse than those of the Middle Ages. Biotechnology may +even alter human evolution, creating “several separate and unequal +species ... that would threaten the notion of equality that is the very +cornerstone of our democracy.” + +• One day, nanobots may go berserk and spew out unlimited +quantities of “gray goo,” which will blanket Earth, smothering all +life. Since these nanobots “digest” ordinary matter and create new +forms of matter, malfunctioning nanobots could run amok and" +"digest much of Earth. “Gray goo would surely be a depressing +ending to our human adventure on Earth, far worse than mere fire +or ice, and one that could stem from a simple laboratory accident. + +Oops,” he wrote. + +• One day, the robots will take over and replace humanity. They will +become so intelligent that they will simply push humanity aside. We +will be left as an evolutionary footnote. “The robots would in no +sense be our children.... On this path our humanity may well be +lost,” he wrote." +"Joy claimed that the dangers unleashed by these three technologies +dwarfed the dangers posed by the atomic bomb in the 1940s. Back then, +Einstein warned of the power of nuclear technology to destroy +civilization: “It has become appallingly obvious that our technology has +exceeded our humanity.” But the atomic bomb was built by a huge +government program that could be tightly regulated, while these +technologies are being developed by private companies that are lightly +regulated, if at all, Joy pointed out. + +Sure, he conceded, these technologies may alleviate some suffering in +the short term. But in the long term, the benefits are overwhelmed by +the fact that they may unleash a scientific Armageddon that may doom +the human race." +"Joy even accused scientists of being selfish and naive as they try to +create a better society. He wrote, “A traditional utopia is a good society +and a good life. A good life involves other people. This techno utopia is +all about ‘I don’t get diseases; I don’t die; I get to have better eyesight +and be smarter’ and all this. If you described this to Socrates or Plato, +they would laugh at you.” + +He concluded by stating, “I think it is no exaggeration to say we are +on the cusp of the further perfection of extreme evil, an evil whose +possibility spreads well beyond that which weapons of mass destruction +bequeathed to the nation-states....” + +The conclusion to all this? “Something like extinction,” he warned. + +As expected, the article sparked a firestorm of controversy." +"As expected, the article sparked a firestorm of controversy. + +That article was written over a decade ago. In terms of high +technology, that is a lifetime. It is now possible to view certain of its +predictions with some hindsight. Looking back at the article and putting +his warnings into perspective, we can easily see that Bill Joy exaggerated +many of the threats coming from these technologies, but he also spurred + + scientists to face up to the ethical, moral, and societal consequences of + +their work, which is always a good thing. + +And his article opened up a discussion about who we are. In +unraveling the molecular, genetic, and neural secrets of the brain, +haven’t we in some sense dehumanized humanity, reducing it to a +bucket of atoms and neurons? If we completely map every neuron of the +brain and trace every neural pathway, doesn’t that remove the mystery +and magic of who we are? + +A RESPONSE TO BILL JOY" +"A RESPONSE TO BILL JOY + +In retrospect, the threats from robotics and nanotechnology are more +distant than Bill Joy thought, and I would argue that with enough +warning, we can take a variety of countermeasures, such as banning +certain avenues of research if they lead to uncontrollable robots, placing +chips in them to shut them off if they become dangerous, and creating +fail-safe devices to immobilize all of them in an emergency. + +More immediate is the threat from biotechnology, where there is the +realistic danger of biogerms that might escape the laboratory. In fact, +Ray Kurzweil and Bill Joy jointly wrote an article criticizing the +publication of the complete genome of the 1918 Spanish flu virus, one of +the most lethal germs in modern history, which killed more people than +World War I. Scientists were able to reassemble the long-dead virus by +examining the corpses and blood of its victims and sequencing its genes, +and then they published it on the web." +"Safeguards already exist against the release of such a dangerous virus, +but steps must be taken to further strengthen them and add new layers +of security. In particular, if a new virus suddenly erupts in some distant +place on Earth, scientists must strengthen rapid-response teams that can +isolate the virus in the wild, sequence its genes, and then quickly +prepare a vaccine to prevent its spread. + +IMPLICATIONS FOR THE FUTURE OF THE MIND + +This debate also has a direct impact on the future of the mind. At +present, neuroscience is still rather primitive. Scientists can read and +videotape simple thoughts from the living brain, record a few memories, + + connect the brain to mechanical arms, enable locked-in patients to +control machines around them, silence specific regions of the brain via +magnetism, and identify the regions of the brain that malfunction in +mental illness." +"In the coming decades, however, the power of neuroscience may +become explosive. Current research is on the threshold of new scientific +discoveries that will likely leave us breathless. One day, we might +routinely control objects around us with the power of the mind, +download memories, cure mental illness, enhance our intelligence, +understand the brain neuron by neuron, create backup copies of the +brain, and communicate with one another telepathically. The world of +the future will be the world of the mind." +"Bill Joy did not dispute the potential of this technology to relieve +human suffering and pain. But what made him look on it with horror +was the prospect of enhanced individuals who might cause the human +species to split apart. In the article, he painted a dismal dystopia in +which only a tiny elite have their intelligence and mental processes +enhanced, while the masses of people live in ignorance and poverty. He +worried that the human race would fission in two, or perhaps cease to be +human at all. + +But as we have pointed out, almost all technologies when they are first +introduced are expensive and hence exclusively for the well-off. Because +of mass production, the falling cost of computers, competition, and +cheaper shipping, technologies inevitably filter down to the poor as well. +This was also the trajectory taken by phonographs, radio, TV, PCs, +laptops, and cell phones." +"Far from creating a world of haves and have-nots, science has been the +engine of prosperity. Of all the tools that humanity has harnessed since +the dawn of time, by far the most powerful and productive has been +science. The incredible wealth we see all around us is directly due to +science. To appreciate how technology reduces, rather than accentuates, +societal fault lines, consider the lives of our ancestors around 1900. Life +expectancy in the United States back then was forty-nine years. Many +children died in infancy. Communicating with a neighbor involved +yelling out the window. The mail was delivered by horse, if it came at +all. Medicine was largely snake oil. The only treatments that actually +worked were amputations (without anesthetics) and morphine to deaden + +the pain. Food rotted within days. Plumbing was nonexistent. Disease +was a constant threat. And the economy could support only a handful of +the rich and a tiny middle class." +"Technology has changed everything. We no longer have to hunt for +our food; we simply go to the supermarket. We no longer have to carry +back-breaking supplies but instead simply get into our cars. (In fact, the +main threat we face from technology, one that has killed millions of +people, is not murderous robots or mad nanobots run amok—it’s our +indulgent lifestyle, which has created near-epidemic levels of diabetes, +obesity, heart disease, cancer, etc. And this problem is self-inflicted.) + +We also see this on the global level. In the last few decades the world +has witnessed hundreds of millions of people being lifted out of grinding +poverty for the first time in history. If we view the bigger picture, we see +that a significant fraction of the human race has left the punishing +lifestyle of sustenance farming and entered the ranks of the middle class." +"It took several hundred years for Western nations to industrialize, yet +China and India are doing it within a few decades, all due to the spread +of high technology. With wireless technology and the Internet, these +nations can leapfrog past other, more developed nations that have +laboriously wired their cities. While the West struggles with an aging, +decaying urban infrastructure, developing nations are building entire +cities with sparkling, state-of-the-art technology." +"(When I was a graduate student getting my Ph.D., my counterparts in +China and India would have to wait several months to a year for +scientific journals to come in the mail. Plus, they had almost no direct +contact with scientists and engineers in the West, because few if any +could afford to travel here. This vastly impeded the flow of technology, +which moved at a glacial pace for these nations. Today, however, +scientists can read one another’s papers as soon as they are posted on the +Internet, and can electronically collaborate with other scientists around +the world. This has vastly accelerated the flow of information. And with +this technology comes progress and prosperity.)" +"Furthermore, it’s not clear that having some form of enhanced +intelligence will cause a catastrophic splitting of the human race, even if +many people are unable to afford this procedure. For the most part, +being able to solve complex mathematical equations or have perfect +recall does not guarantee a higher income, respect from your peers, or + +more popularity with the opposite sex, which are the incentives that +motivate most people. The Caveman Principle trumps having a brain +boost. + +As Dr. Michael Gazzaniga notes, “The idea that we are messin’ with +our innards is disturbing to many. And just what would we do with +expanded intelligence? Are we going to use it for solving problems, or +will it just allow us to have longer Christmas card lists ...?”" +"But as we discussed in Chapter 5, unemployed workers may benefit +from this technology, drastically reducing the time required to master +new technologies and skills. This might not only reduce the problems +associated with unemployment, it could also have an impact on the +world economy, making it more efficient and responsive to change. + +WISDOM AND DEMOCRATIC DEBATE + +In responding to Joy’s article, some critics pointed out that the debate is +not about a struggle between scientists and nature, as portrayed in the +article. The debate is actually between three parties: scientists, nature, +and society." +"Computer scientists Drs. John Brown and Paul Duguid responded to +the article by stating, “Technologies—such as gunpowder, the printing +press, the railroad, the telegraph, and the Internet—can change society +in profound ways. But on the other hand, social systems—in the form of +governments, the courts, formal and informal organizations, social +movements, professional networks, local communities, market +institutions, and so forth—shape, moderate, and redirect the raw power +of technologies.” + +The point is to analyze them in terms of society, and ultimately it is up +to us to adopt a new vision of the future that incorporates all the best +ideas. + +To me, the ultimate source of wisdom in this respect comes from +vigorous democratic debate. In the coming decades, the public will be +asked to vote on a number of crucial scientific issues. Technology cannot +be debated in a vacuum. + +PHILOSOPHICAL QUESTIONS" +"PHILOSOPHICAL QUESTIONS + +Lastly, some critics have claimed that the march of science has gone too +far in unveiling the secrets of the mind, an unveiling that has become +dehumanizing and degrading. Why bother to rejoice at discovering +something new, learning a new skill, or enjoying a leisurely vacation +when it can all be reduced to a few neurotransmitters activating a few +neural circuits? + +In other words, just as astronomy has reduced us to insignificant +pieces of cosmic dust floating in an uncaring universe, neuroscience has +reduced us to electrical signals circulating within neural circuits. But is +this really true?" +"We began our discussion by highlighting the two greatest mysteries in +all of science: the mind and the universe. Not only do they have a +common history and narrative, they also share a similar philosophy and +perhaps even destiny. Science, with all its power to peer into the heart of +black holes and land on distant planets, has given birth to two +overarching philosophies about the mind and the universe: the +Copernican Principle and the Anthropic Principle. Both are consistent +with everything known about science, but they are diametrical +opposites. + +The first great philosophy, the Copernican Principle, was born with +the discovery of the telescope more than four hundred years ago. It +states that there is no privileged position for humanity. Such a +deceptively simple idea has overthrown thousands of years of cherished +myths and entrenched philosophies." +"Ever since the biblical tale of Adam and Eve being exiled from the +Garden of Eden for biting into the Apple of Knowledge, there has been a +series of humiliating dethronements. First, the telescope of Galileo +clearly showed that Earth was not the center of the solar system—the +sun was. This picture was then overthrown when it was realized that the +solar system was just a speck in the Milky Way galaxy circulating about +thirty thousand light-years from the center. Then in the 1920s, Edwin +Hubble discovered there was a multitude of galaxies. The universe +suddenly got billions of times bigger. Now the Hubble Space Telescope +can reveal the presence of up to one hundred billion galaxies in the +visible universe. Our own Milky Way galaxy has been reduced to a +pinpoint in a much larger cosmic arena. + +More recent cosmological theories further downgrade the position of" +"More recent cosmological theories further downgrade the position of + +humanity in the universe. The inflationary universe theory states that +our visible universe, with its one hundred billion galaxies, is just a +pinprick on a much larger, inflated universe that is so big that most light +has not had time to reach us yet from distant regions. There are vast +reaches of space that we cannot see with our telescopes and will never +be able to visit because we cannot go faster than light. And if string +theory (my specialty) is correct, it means that even the entire universe +coexists with other universes in eleven-dimensional hyperspace. So even +three-dimensional space is not the final word. The true arena for +physical phenomena is the multiverse of universes, full of floating +bubble universes. + +The science-fiction writer Douglas Adams tried to summarize the sense +of being constantly overthrown by inventing the Total Perspective +Vortex in The Hitchhiker’s Guide to the Galaxy. It was designed to drive" +"any sane person insane. When you enter the chamber, all you see is a +gigantic map of the entire universe. And on the map there is a tiny, +almost invisible arrow that says, “You are here.” + +So on one hand, the Copernican Principle indicates that we are just +insignificant cosmic debris drifting aimlessly among the stars. But on the +other hand, all the latest cosmological data are consistent with yet +another theory, which gives us the opposite philosophy: the Anthropic +Principle. + +This theory states that the universe is compatible with life. Again, this +deceptively simple statement has profound implications. On one hand, it +is impossible to dispute that life exists in the universe. But it’s clear that +the forces of the universe must be calibrated to a remarkable degree to +make life possible. As physicist Freeman Dyson once said, “The universe +seemed to know that we were coming.”" +"For example, if the nuclear force were just a bit stronger, the sun +would have burned out billions of years ago, too soon to allow DNA to +get off the ground. If the nuclear force were a bit weaker, then the sun +would never have ignited to begin with, and we still would not be here. + +Likewise, if gravity were stronger, the universe would have collapsed +into a Big Crunch billions of years ago, and we would all be roasted to +death. If it were a bit weaker, then the universe would have expanded so +fast it would have reached the Big Freeze, so we would all have frozen to +death. + +This fine-tuning extends to every atom of the body. Physics says that +we are made of star dust, that the atoms we see all around us were +forged in the heat of a star. We are literally children of the stars." +"But the nuclear reactions that burned hydrogen to create the higher +elements of our body are very complex and could have been derailed at +any number of points. Then it would have been impossible to create the +higher elements of our bodies, and the atoms of DNA and life would not +exist. + +In other words, life is precious and a miracle. + +There are so many parameters that have to be fine-tuned that some +claim this is not a coincidence. The weak form of the Anthropic Principle +implies that the existence of life forces the physical parameters of the +universe to be defined in a very precise way. The strong form of the +Anthropic Principle goes even further, stating that God or some designer +had to create a universe “just right” to make life possible. + + PHILOSOPHY AND NEUROSCIENCE" +"PHILOSOPHY AND NEUROSCIENCE + +The debate between the Copernican Principle and the Anthropic +Principle also resonates in neuroscience. For example, some claim that +humans can be reduced to atoms, molecules, and neurons, and hence +there is no distinguished place for humanity in the universe. + +Dr. David Eagleman writes, “The you that all your friends know and +love cannot exist unless the transistors and screws of our brain are in +place. If you don’t believe this, step into any neurology ward in any +hospital. Damage to even small parts of the brain can lead to the loss of +shockingly specific abilities; the ability to name animals, or to hear +music, or to manage risky behavior, or to distinguish colors, or to +arbitrate simple decisions.” + +It seems that the brain cannot function without all its “transistors and +screws.” He concludes, “Our reality depends on what our biology is up +to.”" +"So on one hand, our place in the universe seems to be diminished if +we can be reduced, like robots, to (biological) nuts and bolts. We are just +wetware, running software called the mind, nothing more or less. Our +thoughts, desires, hopes, and aspirations can be reduced to electrical + +impulses circulating in some region of the prefrontal cortex. That is the +Copernican Principle applied to the mind. + +But the Anthropic Principle can also be applied to the mind, and we +then reach the opposite conclusion. It simply says that conditions of the +universe make consciousness possible, even though it is extraordinarily +difficult to create the mind out of random events. The great Victorian +biologist Thomas Huxley said, “How it is that anything so remarkable as +a state of consciousness comes about as a result of irritating nervous +tissue, is just as unaccountable as the appearance of the Djinn, when +Aladdin rubbed his lamp.”" +"Furthermore, most astronomers believe that although one day we may +find life on other planets, it will most likely be microbial life, which +ruled our oceans for billions of years. Instead of seeing great cities and +empires, we might only find oceans of drifting microorganisms. + +When I interviewed the late Harvard biologist Stephen Jay Gould +about this, he explained to me his thinking as follows. If we were to +somehow create a twin of Earth as it was 4.5 billion years ago, would it +turn out the same way 4.5 billion years later? Most likely not. There is a + + large probability that DNA and life would never have gotten off the +ground, and an even larger probability that intelligent life with +consciousness would never have risen from the swamp." +"Gould wrote, “Homo sapiens is one small twig [on the tree of life]. +... Yet our twig, for better or worse, has developed the most +extraordinary new quality in all the history of multicellular life since the +Cambrian explosion (500 million years ago). We have invented +consciousness with all its sequelae from Hamlet to Hiroshima.”" +"In fact, in the history of Earth, there are many times when intelligent +life was almost extinguished. In addition to the mass extinctions that +wiped out the dinosaurs and most life on Earth, humans have faced +additional near extinctions. For example, humans are all genetically +related to one another to a considerable degree, much closer than two +typical animals of the same species. Although humans may look diverse +from the outside, our genes and internal chemistry tell a different story. +In fact, any two humans are so closely related genetically that we can +actually do the math and calculate when a “genetic Eve” or “genetic +Adam” gave birth to the entire human race. Moreover, we can calculate +how many of us there were in the past." +"The numbers are remarkable. Genetics shows that there were only a +few hundred to a few thousand humans alive about seventy to one +hundred thousand years ago and that they gave birth to the entire +human race. (One theory holds that the titanic explosion of the Toba +volcano in Indonesia about seventy thousand years ago caused +temperatures to drop so dramatically that most of the human race +perished, leaving only a handful to populate Earth.) From that small +band of humans came the adventurers and explorers who would +eventually colonize the entire planet. + +Repeatedly in the history of Earth, intelligent life might have come to +a dead end. It is a miracle we survived. We can also conclude that +although life may exist on other planets, conscious life may exist on only +a tiny fraction of them. So we should treasure the consciousness that is +found on Earth. It is the highest form of complexity known in the +universe, and probably also the rarest." +"Sometimes, when contemplating the future destiny of the human race, +I have to come to grips with the distinct possibility of its self-destruction. +Although volcanic eruptions and earthquakes could spell doom for the +human race, our worst fears may be realized through man-made +disasters, such as nuclear wars or bioengineered germs. If so, then +perhaps the only conscious life-form in this sector of the Milky Way +galaxy might be extinguished. This, I feel, would be a tragedy not just +for us, but for the universe as well. We take for granted that we are + + conscious, but we don’t understand the long, tortuous sequence of +biological events that have transpired to make this possible. Psychologist +Steven Pinker writes, “I would argue that nothing gives life more +purpose than the realization that every moment of consciousness is a +precious and fragile gift.” + +THE MIRACLE OF CONSCIOUSNESS" +"THE MIRACLE OF CONSCIOUSNESS + +Lastly, there is the criticism of science that says to understand something +is to remove its mystery and magic. Science, by lifting the veil +concealing the secrets of the mind, is also making it more ordinary and +mundane. However, the more I learn about the sheer complexity of the +brain, the more amazed I am that something that sits on our shoulders is + +the most sophisticated object we know about in the universe. As Dr. +David Eagleman says, “What a perplexing masterpiece the brain is, and +how lucky we are to be in a generation that has the technology and the +will to turn our attention to it. It is the most wondrous thing we have +discovered in the universe, and it is us.” Instead of diminishing the sense +of wonder, learning about the brain only increases it. + +More than two thousand years ago, Socrates said, “To know thyself is +the beginning of wisdom.” We are on a long journey to complete his +wishes. + +APPENDIX + +QUANTUM CONSCIOUSNESS?" +"APPENDIX + +QUANTUM CONSCIOUSNESS? + +In spite of all the miraculous advances in brain scans and high +technology, some people claim that we will never understand the secret +of consciousness, since consciousness is beyond our puny technology. In +fact, in their view consciousness is more fundamental than atoms, +molecules, and neurons and determines the nature of reality itself. To +them, consciousness is the fundamental entity out of which the material +world is created. And to prove their point, they refer to one of the +greatest paradoxes in all of science, which challenges our very definition +of reality: the Schrodinger’s Cat paradox. Even today, there is no +universal consensus on the question, with Nobel laureates taking +divergent stances. What is at stake is nothing less than the nature of +reality and thought." +"The Schrodinger’s Cat paradox cuts to the very foundation of quantum +mechanics, a field that makes lasers, MRI scans, radio and TV, modern +electronics, the GPS, and telecommunications possible, upon which the +world economy depends. Many of quantum theory’s predictions have +been tested to an accuracy of one part in one hundred billion. + +I have spent my entire professional career working on the quantum +theory. Yet I realize that it has feet of clay. It’s an unsettling feeling +knowing my life’s work is based on a theory whose very foundation is +based on a paradox." +"This debate was sparked by Austrian physicist Erwin Schrodinger, who +was one of the founding fathers of the quantum theory. He was trying to +explain the strange behavior of electrons, which seemed to exhibit both +wave and particle properties. How can an electron, a point particle, have +two divergent behaviors? Sometimes electrons acted like a particle, +creating well-defined tracks in a cloud chamber. Other times, electrons +acted like a wave, passing through tiny holes and creating wavelike +interference patterns, like those on the surface of a pond. + +In 1925, Schrodinger put forward his celebrated wave equation, which" +"In 1925, Schrodinger put forward his celebrated wave equation, which + +bears his name and is one of the most important equations ever written. +It was an instant sensation, and won him the Nobel Prize in 1933. The +Schrodinger equation accurately described the wavelike behavior of +electrons and, when applied to the hydrogen atom, explained its strange +properties. Miraculously, it could also be applied to any atom and +explain most of the features of the periodic table of elements. It seemed +as if all chemistry (and hence all biology) were nothing but solutions of +this wave equation. Some physicists even claimed that the entire +universe, including all the stars, planets, and even us, was nothing but a +solution of this equation. + +But then physicists began to ask a problematic question that resonates +even today: If the electron is described by a wave equation, then what is +waving?" +"In 1927, Werner Heisenberg proposed a new principle that split the +physics community down the middle. Heisenberg’s celebrated +uncertainty principle states that you cannot know both the location and +the momentum of an electron with certainty. This uncertainty was not a +function of how crude your instruments were but was inherent in +physics itself. Even God or some celestial being could not know the +precise location and momentum of an electron. + +So the wave function of Schrodinger actually described the probability +of finding the electron. Scientists had spent thousands of years painfully + + trying to eliminate chance and probabilities in their work, and now +Heisenberg was allowing it in through the back door. + +The new philosophy can be summed up as follows: the electron is a +point particle, but the probability of finding it is given by a wave. And +this wave obeys Schrodinger’s equation and gives rise to the uncertainty +principle." +"The physics community cracked in half. On one side, we had +physicists like Niels Bohr, Werner Heisenberg, and most atomic +physicists eagerly adopting this new formulation. Almost daily, they +were announcing new breakthroughs in understanding the properties of +matter. Nobel Prizes were being handed out to quantum physicists like +Oscars. Quantum mechanics was becoming a cookbook. You did not +need to be a master physicist to make stellar contributions—you just +followed the recipes given by quantum mechanics and you would make +stunning breakthroughs. + +On the other side, we had aging Nobel laureates like Albert Einstein, +Erwin Schrodinger, and Louis de Broglie who were raising philosophical +objections. Schrodinger, whose work helped start this whole process, +grumbled that if he had known that his equation would introduce +probability into physics, he would never have created it in the first +place." +"Physicists embarked on an eighty-year debate that continues even +today. On one hand, Einstein would proclaim that “God does not play +dice with the world.” Niels Bohr, on the other hand, reportedly replied, +“Stop telling God what to do.” + +In 1935, to demolish the quantum physicists once and for all, +Schrodinger proposed his celebrated cat problem. Place a cat in a sealed +box, with a container of poison gas. In the box, there is a lump of +uranium. The uranium atom is unstable and emits particles that can be +detected by a Geiger counter. The counter triggers a hammer, which falls +and breaks the glass, releasing the gas, which can kill the cat." +"How do you describe the cat? A quantum physicist would say that the +uranium atom is described by a wave, which can either decay or not +decay. Therefore you have to add the two waves together. If the uranium +fires, then the cat dies, so that is described by one wave. If the uranium +does not fire, then the cat lives, and that is also described by a wave. To +describe the cat, you therefore have to add the wave of a dead cat to the +wave of a live cat. + +This means that the cat is neither dead nor alive! The cat is in a +netherworld, between life and death, the sum of the wave describing a + + dead cat with the wave of a live cat. + +This is the crux of the problem, which has reverberated in the halls of +physics for almost a century. So how do you resolve this paradox? There +are at least three ways (and hundreds of variations on these three)." +"The first is the original Copenhagen interpretation proposed by Bohr +and Heisenberg, the one that is quoted in textbooks around the world. (It +is the one that I start with when I teach quantum mechanics.) It says that +to determine the state of the cat, you must open the box and make a +measurement. The cat’s wave (which was the sum of a dead cat and a +live cat) now “collapses” into a single wave, so the cat is now known to +be alive (or dead). Thus, observation determines the existence and state +of the cat. The measurement process is thus responsible for two waves + +magically dissolving into a single wave." +"magically dissolving into a single wave. + +Einstein hated this. For centuries, scientists have battled something +called “solipsism” or “subjective idealism,” which claims that objects +cannot exist unless there is someone there to observe them. Only the +mind is real—the material world exists only as ideas in the mind. Thus, +say the solipsists (such as Bishop George Berkeley), if a tree falls in the +forest but no one is there to observe it, perhaps the tree never fell. +Einstein, who thought all this was pure nonsense, promoted an opposing +theory called “objective reality,” which says simply that the universe +exists in a unique, definite state independent of any human observation. +It is the commonsense view of most people." +"Objective reality goes back to Isaac Newton. In this scenario, the atom +and subatomic particles are like tiny steel balls, which exist at definite +points in space and time. There is no ambiguity or chance in locating the +position of these balls, whose motions can be determined by using the +laws of motion. Objective reality was spectacularly successful in +describing the motions of planets, stars, and galaxies. Using relativity, +this idea can also describe black holes and the expanding universe. But +there is one place where it fails miserably, and that is inside the atom. + +Classical physicists like Newton and Einstein thought that objective +reality finally banished solipsism from physics. Walter Lippmann, the +columnist, summed it up when he wrote, “The radical novelty of modern +science lies precisely in the rejection of the belief ... that the forces +which move the stars and atoms are contingent upon the preferences of +the human heart.”" +"But quantum mechanics allowed a new form of solipsism back into +physics. In this picture, before it is observed, a tree can exist in any +possible state (e.g., sapling, burned, sawdust, toothpicks, decayed). But + + when you look at it, the wave suddenly collapses and it looks like a tree. +The original solipsists talked about trees that either fell or didn’t. The +new quantum solipsists were introducing all possible states of a tree. + +This was too much for Einstein. He would ask guests at his house, +“Does the moon exist because a mouse looks at it?” To a quantum +physicist, in some sense the answer might be yes. + +Einstein and his colleagues would challenge Bohr by asking: How can +the quantum microworld (with cats being dead and alive +simultaneously) coexist with the commonsense world we see around us?" +"The answer was that there is a “wall” that separates our world from the +atomic world. On one side of the wall, common sense rules. On the other +side of the wall, the quantum theory rules. You can move the wall if you +want and the results are still the same. + +This interpretation, no matter how strange, has been taught for eighty +years by quantum physicists. More recently, there have been some +doubts cast on the Copenhagen interpretation. Today we have +nanotechnology, with which we can manipulate individual atoms at will. +On a scanning tunneling microscope screen, atoms appear to be fuzzy +tennis balls. (For BBC-TV, I had a chance to fly out to IBM’s Almaden +Lab in San Jose, California, and actually push individual atoms around +with a tiny probe. It is now possible to play with atoms, which were +once thought to be so small they could never be seen.)" +"As we’ve discussed, the Age of Silicon is slowly coming to an end, and +some believe that molecular transistors will replace silicon transistors. If +so, then the paradoxes of the quantum theory may lie at the very heart +of every computer of the future. The world economy may eventually rest +on these paradoxes. + +COSMIC CONSCIOUSNESS AND MULTIPLE UNIVERSES + +There are two alternate interpretations of the cat paradox, which take us +to the strangest realms in all science: the realm of God and multiple +universes. + +In 1967, the second resolution to the cat problem was formulated by +Nobel laureate Eugene Wigner, whose work was pivotal in laying the +foundation of quantum mechanics and also building the atomic bomb. +He said that only a conscious person can make an observation that +collapses the wave function. But who is to say that this person exists? +You cannot separate the observer from the observed, so maybe this" +"person is also dead and alive. In other words, there has to be a new +wave function that includes both the cat and the observer. To make sure +that the observer is alive, you need a second observer to watch the first +observer. This second observer is called “Wigner’s friend,” and is +necessary to watch the first observer so that all waves collapse. But how +do we know that the second observer is alive? The second observer has + +to be included in a still-larger wave function to make sure he is alive, +but this can be continued indefinitely. Since you need an infinite number +of “friends” to collapse the previous wave function to make sure they are +alive, you need some form of “cosmic consciousness,” or God. + +Wigner concluded: “It was not possible to formulate the laws (of +quantum theory) in a fully consistent way without reference to +consciousness.” Toward the end of his life, he even became interested in +the Vedanta philosophy of Hinduism." +"In this approach, God or some eternal consciousness watches over all +of us, collapsing our wave functions so that we can say we are alive. This +interpretation yields the same physical results as the Copenhagen +interpretation, so this theory cannot be disproven. But the implication is +that consciousness is the fundamental entity in the universe, more +fundamental than atoms. The material world may come and go, but +consciousness remains as the defining element, which means that +consciousness, in some sense, creates reality. The very existence of the +atoms we see around us is based on our ability to see and touch them." +"(At this point, it’s important to note that some people think that +because consciousness determines existence, then consciousness can +therefore control existence, perhaps by meditation. They think that we +can create reality according to our wishes. This thinking, as attractive as +it might sound, goes against quantum mechanics. In quantum physics, +consciousness makes observations and therefore determines the state of +reality, but consciousness cannot choose ahead of time which state of +reality actually exists. Quantum mechanics allows you only to determine +the chance of finding one state, but we cannot bend reality to our +wishes. For example, in gambling, it is possible to mathematically +calculate the chances of getting a royal flush. However, this does not +mean that you can somehow control the cards to get the royal flush. You +cannot pick and choose universes, just as we have no control over +whether the cat is dead or alive.) + +MULTIPLE UNIVERSES" +"MULTIPLE UNIVERSES + +The third way to resolve the paradox is the Everett, or many-worlds, + + interpretation, which was proposed in 1957 by Hugh Everett. It is the + +strangest theory of all. It says that the universe is constantly splitting +apart into a multiverse of universes. In one universe, we have a dead cat. +In another universe, we have a live cat. This approach can be +summarized as follows: wave functions never collapse, they just split. +The Everett many-worlds theory differs from the Copenhagen +interpretation only in that it drops the final assumption: the collapse of +the wave function. In some sense, it is the simplest formulation of +quantum mechanics, but also the most disturbing. + +There are profound consequences to this third approach. It means that +all possible universes might exist, even ones that are bizarre and +seemingly impossible. (However, the more bizarre the universe, the +more unlikely it is.)" +"This means people who have died in our universe are still alive in +another universe. And these dead people insist that their universe is the +correct one, and that our universe (in which they are dead) is fake. But if +these “ghosts” of dead people are still alive somewhere, then why can’t +we meet them? Why can’t we touch these parallel worlds? (As strange as +it may seem, in this picture Elvis is still alive in one of these universes.)" +"What’s more, some of these universes may be dead, without any life, +but others may look exactly like ours, except for one key difference. For +example, the collision of a single cosmic ray is a tiny quantum event. But +what happens if this cosmic ray goes through Adolf Hitler’s mother, and +the infant Hitler dies in a miscarriage? Then a tiny quantum event, the +collision of a single cosmic ray, causes the universe to split in half. In +one universe, World War II never happened, and sixty million people did +not have to die. In the other universe, we’ve had the ravages of World +War II. These two universes grow to be quite far apart, yet they are +initially separated by one tiny quantum event." +"This phenomenon was explored by science-fiction writer Philip K. Dick +in his novel The Man in the High Tower, where a parallel universe opens +up because of a single event: a bullet is fired at Franklin Roosevelt, who +is killed by an assassin. This pivotal event means that the United States +is not prepared for World War II, and the Nazis and Japanese are +victorious and eventually partition the United States in half. + +But whether the bullet fires or misfires depends, in turn, on whether a +microscopic spark is set off in the gunpowder, which itself depends on +complex molecular reactions involving the motions of electrons. So + + perhaps quantum fluctuations in the gunpowder may determine whether +the gun fires or misfires, which in turn determines whether the Allies or +the Nazis emerge victorious during World War II." +"So there is no “wall” separating the quantum world and the +macroworld. The bizarre features of the quantum theory can creep into +our “commonsense” world. These wave functions never collapse—they +keep splitting endlessly into parallel realities. The creation of alternative +universes never stops. The paradoxes of the microworld (i.e., being dead +and alive simultaneously, being in two places at the same time, +disappearing and reappearing somewhere else) now enter into our world +as well. + +But if the wave function is continually splitting apart, creating entirely +new universes in the process, then why can’t we visit them?" +"Nobel laureate Steven Weinberg compares this to listening to the radio +in your living room. There are hundreds of radio waves simultaneously +filling up your room from all over the world, but your radio dial is tuned +to only one frequency. In other words, your radio has “decohered” from +all the other stations. (Coherence is when all waves vibrate in perfect +unison, as in a laser beam. Decoherence is when these waves begin to +fall out of phase, so they no longer vibrate in unison.) These other +frequencies all exist, but your radio cannot pick them up because they +are not vibrating at the same frequency that we are anymore. They have +decoupled; that is, they have decohered from us." +"In the same way, the wave function of the dead and alive cat have +decohered as time goes on. The implications are rather staggering. In +your living room, you coexist with the waves of dinosaurs, pirates, aliens +from space, and monsters. Yet you are blissfully unaware that you are +sharing the same space as these strange denizens of quantum space, +because your atoms are no longer vibrating in unison with them. These +parallel universes do not exist in some distant never-never land. They +exist in your living room. + +Entering one of these parallel worlds is called “quantum jumping” or +“sliding” and is a favorite gimmick of science fiction. To enter a parallel +universe, we need to take a quantum jump into it. (There was even a TV +series called Sliders where people slide back and forth between parallel +universes. The series began when a young boy read a book. That book is +actually my book Hyperspace, but I take no responsibility for the physics + +behind that series.)" +"behind that series.) + +Actually, it’s not so simple to jump between universes. One problem +we sometimes give our Ph.D. students is to calculate the probability that + + you will jump through a brick wall and wind up on the other side. The +result is sobering. You would have to wait longer than the lifetime of the +universe to experience jumping or sliding through a brick wall. + +LOOKING IN THE MIRROR" +"LOOKING IN THE MIRROR + +When I look at myself in a mirror, I don’t really see myself as I truly am. +First, I see myself about a billionth of a second ago, since that is the time +that it takes a light beam to leave my face, hit a mirror, and enter my +eyes. Second, the image I see is really an average over billions and +billions of wave functions. This average certainly does resemble my +image, but it is not exact. Surrounding me are multiple images of myself +oozing in all directions. I am continually surrounded by alternate +universes, forever branching into different worlds, but the probability of +sliding between them is so tiny that Newtonian mechanics seems to be +correct." +"At this point, some people ask this question: Why don’t scientists +simply do an experiment to determine which interpretation is valid? If +we run an experiment with an electron, all three interpretations will +yield the same result. All three are therefore serious, viable +interpretations of quantum mechanics, with the same underlying +quantum theory. What is different is how we explain the results. + +Hundreds of years in the future, physicists and philosophers may still +be debating this question, with no resolution, because all three +interpretations yield the same physical results. But perhaps there is one +way in which this philosophical debate touches on the brain, and that is +the question of free will, which in turn affects the moral foundation of +human society. + +FREE W ILT. + +Our entire civilization is based on the concept of free will, which +impacts on the notions of reward, punishment, and personal" +"responsibility. But does free will really exist? Or is it a clever way of +keeping society together although it violates scientific principles? The +controversy goes to the very heart of quantum mechanics itself. + +It is safe to say that more and more neuroscientists are gradually +coming to the conclusion that free will does not exist, at least not in the +usual sense. If certain bizarre behaviors can be linked to precise defects + + in the brain, then a person is not scientifically responsible for the crimes +he might commit. He might be too dangerous to be left walking the +streets and must be locked up in an institution of some sort, but +punishing someone for having a stroke or tumor in the brain is +misguided, they say. What that person needs is medical and +psychological help. Perhaps the brain damage can be treated (e.g., by +removing a tumor), and the person can become a productive member of +society." +"For example, when I interviewed Dr. Simon Baron-Cohen, a +psychologist at Cambridge University, he told me that many (but not all) +pathological killers have a brain anomaly. Their brain scans show that +they lack empathy when seeing someone else in pain, and in fact they +might even take pleasure in watching this suffering (in these individuals, +the amygdala and the nucleus accumbens, the pleasure center, light up +when they view videos of people experiencing pain). + +The conclusion some might draw from this is that these people are not +truly responsible for their heinous acts, although they should still be +removed from society. They need help, not punishment, because of a +problem with their brain. In a sense, they may not be acting with free +will when they commit their crimes." +"An experiment done by Dr. Benjamin Libet in 1985 casts doubt on the +very existence of free will. Let’s say that you are asking subjects to watch +a clock and then to note precisely when they decide to move a finger. +Using EEG scans, one can detect exactly when the brain makes this +decision. When you compare the two times, you will find a mismatch. +The EEG scans show that the brain has actually made the decision about +three hundred milliseconds before the person becomes aware of it. + +This means that, in some sense, free will is a fake. Decisions are made +ahead of time by the brain, without the input of consciousness, and then +later the brain tries to cover this up (as it’s wont to do) by claiming that +the decision was conscious. Dr. Michael Sweeney concludes, “Libet’s + +findings suggested that the brain knows what a person will decide before +the person does.... The world must reassess not only the idea of +movements divided between voluntary and involuntary, but also the +very idea of free will.”" +"All this seems to indicate that free will, the cornerstone of society, is a +fiction, an illusion created by our left brain. So are we masters of our +fate, or just pawns in a swindle perpetuated by the brain? + +There are several ways to approach this sticky question. Free will goes +against a philosophy called determinism, which simply says that all + + future events are determined by physical laws. According to Newton +himself, the universe was some sort of clock, ticking away since the +beginning of time, obeying the laws of motion. Hence all events are +predictable. + +The question is: Are we part of this clock? Are all our actions also +determined? These questions have philosophical and theological +implications. For example, most religions adhere to some form of +determinism and predestination. Since God is omnipotent, omniscient, +and omnipresent, He knows the future, and hence the future is +determined ahead of time. He knows even before you are born whether +you will go to Heaven or Hell." +"The Catholic Church split in half on this precise question during the +Protestant revolution. According to Catholic doctrine at that time, one +could change one’s ultimate fate with an indulgence, usually by making +generous financial donations to the Church. In other words, determinism +could be altered by the size of your wallet. Martin Luther specifically +singled out the corruption of the Church over indulgences when he +tacked his 95 Theses on the door of a church in 1517, triggering the +Protestant Reformation. This was one of the key reasons why the Church +split down the middle, causing casualties in the millions and laying +waste to entire regions of Europe." +"But after 1925, uncertainty was introduced into physics via quantum +mechanics. Suddenly everything became uncertain; all you could +calculate was probabilities. In this sense, perhaps free will does exist, +and it’s a manifestation of quantum mechanics. So some claim that the +quantum theory reestablishes the concept of free will. The determinists +have fought back, however, claiming that quantum effects are extremely +small (at the level of atoms), too small to account for the free will of + +large human beings. + +The situation today is actually rather muddled. Perhaps the question +“Does free will exist?” is like the question “What is life?” The discovery +of DNA has rendered that question about life obsolete. We now realize +that the question has many layers and complexities. Perhaps the same +applies to free will, and there are many types." +"If so, the very definition of “free will” becomes ambiguous. For +example, one way to define free will is to ask whether behavior can be +predicted. If free will exists, then behavior cannot be determined ahead +of time. Let’s say you watch a movie, for example. The plot is completely +determined, with no free will whatsoever. So the movie is completely +predictable. But our world cannot be like a movie, for two reasons. The +first is the quantum theory, as we have seen. The movie represents only + + one possible timeline. The second reason is chaos theory. Although +classical physics says that all of the motions of atoms are completely +determined and predictable, in practice it is impossible to predict their +motions because there are so many atoms involved. The slightest +disturbance of a single atom can have a ripple effect, which can cascade +down to create enormous disturbances." +"Think of the weather. In principle, if you knew the behavior of every +atom in the air, you could predict the weather a century from now if you +had a big enough computer. But in practice, this is impossible. After just +a few hours, the weather becomes so turbulent and complex that any +computer simulation is rendered useless. + +This creates what is called the “butterfly effect,” which means that +even the beat of butterfly wings can cause tiny ripples in the +atmosphere, which grow and in turn can escalate into a thunderstorm. +So if even the flapping of butterfly wings can create thunderstorms, the +hope of accurately predicting the weather is far-fetched. + +Let’s go back to the thought experiment described to me by Stephen +Jay Gould. He asked me to imagine Earth 4.5 billion years ago, when it +was born. Now imagine you could somehow create an identical copy of +Earth, and let it evolve. Would we still be here on this different Earth 4.5 +billion years later?" +"One could easily imagine, due to quantum effects or the chaotic nature +of the weather and oceans, that humanity would never evolve into +precisely the same creatures on this version of Earth. So ultimately, it + +seems a combination of uncertainty and chaos makes a perfectly +deterministic world impossible. + +THE QUANTUM BRAIN + +This debate also affects the reverse engineering of the brain. If you can +successfully reverse engineer a brain made of transistors, this success +implies that the brain is deterministic and predictable. Ask it any +question and it repeats the exact same answer. Computers are +deterministic in this way, since they always give the same answer for +any question. + +So it seems we have a problem. On one hand, quantum mechanics and +chaos theory claim that the universe is not predictable, and therefore, +free will seems to exist. But a reverse-engineered brain, made of +transistors, would by definition be predictable. Since the reverse-" +"engineered brain is theoretically identical to a living brain, then the +human brain is also deterministic and there is no free will. Clearly, this +contradicts the first statement." +"A minority of scientists claim that you cannot authentically reverse +engineer the brain, or ever create a true thinking machine, because of +the quantum theory. The brain, they argue, is a quantum device, not just +a collection of transistors. Hence this project is doomed to fail. In this +camp is Oxford physicist Dr. Roger Penrose, an authority on Einstein’s +theory of relativity, who claims that it is quantum processes that may +account for the consciousness of the human brain. Penrose starts by +saying that mathematician Kurt Godel has proven that arithmetic is +incomplete; that is, that there are true statements in arithmetic that +cannot be proven using the axioms of arithmetic. Similarly, not only is +mathematics incomplete, but so is physics. He concludes by stating that +the brain is basically a quantum mechanical device and there are +problems that no machine can solve because of Godel’s incompleteness +theorem. Humans, however, can make sense of these conundrums using +intuition." +"Similarly, the reverse-engineered brain, no matter how complex, is +still a collection of transistors and wires. In such a deterministic system, +you can accurately predict its future behavior because the laws of + +motion are well known. In a quantum system, however, the system is +inherently unpredictable. All you can calculate are the chances that +something will occur, because of the uncertainty principle. + +If it turns out that the reverse-engineered brain cannot reproduce +human behavior, then scientists may be forced to admit that there are +unpredictable forces at work (i.e., quantum effects inside the brain). Dr. +Penrose argues that inside the neuron there are tiny structures, called +microtubules, where quantum processes dominate." +"At present, there is no consensus on this problem. Judging from the +reaction to Penrose’s idea when it was first proposed, it would be safe to +say that most of the scientific community is skeptical of his approach. +Science, however, is never conducted as a popularity contest, but instead +advances through testable, reproducible, and falsifiable theories. + +For my own part, I believe transistors cannot truly model all the +behaviors of neurons, which carry out both analog and digital +calculations. We know that neurons are messy. They can leak, misfire, +age, die, and are sensitive to the environment. To me, this suggests that +a collection of transistors can only approximately model the behavior of +neurons. For example, we saw earlier, in discussing the physics of the +brain, that if the axon of the neuron becomes thinner, then it begins to" +"leak and also does not carry out chemical reactions that well. Some of +this leakage and these misfires will be due to quantum effects. As you try +to imagine neurons that are thinner, denser, and faster, quantum effects +become more obvious. This means that even for normal neurons there +are problems of leakage and instabilities, and these problems exist both +classically and quantum mechanically. + +In conclusion, a reverse-engineered robot will give a good but not +perfect approximation of the human brain. Unlike Penrose, I think it is +possible to create a deterministic robot out of transistors that gives the +appearance of consciousness, but without any free will. It will pass the +Turing test. But I think there will be differences between such a robot +and humans due to these tiny quantum effects." +"Ultimately, I think free will probably does exist, but it is not the free +will envisioned by rugged individualists who claim they are complete +masters of their fate. The brain is influenced by thousands of +unconscious factors that predispose us to make certain choices ahead of +time, even if we think we made them ourselves. This does not + +necessarily mean that we are actors in a film that can be rewound +anytime. The end of the movie hasn’t been written yet, so strict +determinism is destroyed by a subtle combination of quantum effects +and chaos theory. In the end, we are still masters of our destiny. + +NOTES + +INTRODUCTION" +"NOTES + +INTRODUCTION + +1 You may have to travel: To see this, define “complex” in terms of the +total amount of information that can be stored. The closest rival to the +brain might be the information contained within our DNA. There are +three billion base pairs in our DNA, each one containing one of four +nucleic acids, labeled A,T,C,G. Therefore the total amount of +information we can store in our DNA is four raised to the three- +billionth power. But the brain can store much more information +among its one hundred billion neurons, which can either fire or not +fire. Hence, there are two raised to the one-hundred-billionth power +possible initial states of the human brain. But while DNA is static, the +states of the brain change every few milliseconds. A simple thought +may contain one hundred generations of neural firings. Hence, there +are two raised to one hundred billion, all raised to the hundredth +power, possible thoughts contained in one hundred generations. But" +"our brains are continually firing, day and night, ceaselessly +computing. Therefore the total number of thoughts possible within N +generations is two raised to the one-hundred-billionth power, all +raised to the Nth power, which is truly astronomical. Therefore the +amount of information that we can store in our brains far exceeds the +information stored within our DNA by a wide margin. In fact, it is the +largest amount of information that we can store in our solar system, +and even possibly in our sector of the Milky Way galaxy. + +2 “The most valuable insights”: Boleyn-Fitzgerald, p. 89. + +3 “All of these questions that philosophers”: Boleyn-Fitzgerald, p. +137. + +CHAPTER 1: UNLOCKING THE MIND + +1 He was semiconscious for weeks: See Sweeney, pp. 207-8. + +2 Dr. John Harlow, the doctor who treated: Carter, p. 24. + +3 In the year A.D. 43, records show: Horstman, p. 87. + +4 “It was like ... standing in the doorway”: Carter, p. 28. + +5 The Transparent Brain: New York Times, April 10, 2013, p. 1." +"5 The Transparent Brain: New York Times, April 10, 2013, p. 1. + +6 “Emotions are not feelings at all”: Carter, p. 83. + +7 the mind is more like a “society of minds”: Interview with Dr. +Minsky for the BBC-TV series Visions of the Future, February 2007. +Also, interview for Science Fantastic national radio broadcast, +November 2009. + +8 consciousness was like a storm raging: Interview with Dr. Pinker in +September 2003 for Exploration national radio broadcast. + +9 “the intuitive feeling we have”: Pinker, “The Riddle of Knowing +You’re Here,” in Your Brain: A User’s Guide (New York: Time Inc. +Specials, 2011). + +10 Consciousness turns out to consist of: Boleyn-Fitzgerald, p. 111. + +11 “indeed a conscious system in its own right”: Carter, p. 52. + +12 I asked him how experiments: Interview with Dr. Michael +Gazzaniga in September 2012 for Science Fantastic national radio +broadcast. + + 13 “The possible implications of this”: Carter, p. 53. + +14 “If that person dies, what happens?”: Boleyn-Fitzgerald, p. 119." +"14 “If that person dies, what happens?”: Boleyn-Fitzgerald, p. 119. + +15 a young king who inherits: Interview with Dr. David Eagleman in +May 2012 for Science Fantastic national radio broadcast. + +16 “people named Denise or Dennis”: Eagleman, p. 63. + +17 “at least 15 % of human females”: Eagleman, p. 43. + +CHAPTER 2: CONSCIOUSNESS—A PHYSICIST’S VIEWPOINT + +1 “We cannot see ultraviolet light”: Pinker, How the Mind Works, pp. +561-65. + +2 “Everybody knows what consciousness is”: Biological Bulletin 215, +no. 3 (December 2008): 216." +"2 “Everybody knows what consciousness is”: Biological Bulletin 215, +no. 3 (December 2008): 216. + +3 We will do so in the notes: Level II consciousness can be counted by +listing the total number of distinct feedback loops when an animal +interacts with members of its species. As a rough guess, Level II +consciousness can be approximated by multiplying the number of +others in an animal’s pack or tribe, multiplied by the total number of +distinct emotions or gestures it uses to communicate with others. +There are caveats to this ranking, however, since this is just a first +guess. + +For example, animals like the wildcat are social, but they are also +solitary hunters, so it appears as if the number of animals in its pack is +one. But that is true only when it is hunting. When it is time to +reproduce, wildcats engage in complex mating rituals, so its Level II +consciousness must take this into account." +"Furthermore, when female wildcats give birth to litters of kittens, +which have to be nursed and fed, the number of social interactions +increases as a consequence. So even for solitary hunters, the number +of members of its species that it interacts with is not one, and the total +number of distinct feedback loops can be quite large. + +Also, if the number of wolves in the pack decreases, then it appears +as if its Level II number decreases correspondingly. To account for +this, we have to introduce the concept of an average Level II number +that is common for the entire species, as well as a specific Level II +consciousness for an individual animal. + + The average Level II number for a given species does not change if +the pack gets smaller, because it is common for the entire species, but +the individual Level II number (because it measures individual mental +activity and consciousness) does change." +"When applied to humans, the average Level II number must take +into account the Dunbar number, which is 150, and represents roughly + +the number of people in our social grouping that we can keep track of. +So the Level II number for humans as a species would be the total +number of distinct emotions and gestures we use to communicate, +multiplied by the Dunbar number of 150. (Individuals can have +different levels of Level II consciousness, since their circle of friends +and the ways they interact with them can vary considerably.) + +We should also note that certain Level I organisms (like insects and +reptiles) can exhibit social behaviors. Ants, when they bump into one +another, exchange information via chemical scents, and bees dance to +communicate the location of flower beds. Reptiles even have a +primitive limbic system. But in the main, they do not exhibit +emotions. + +4 “The difference between man”: Gazzaniga, p. 27. + +5 “The greatest achievement of the human brain”: Gilbert, p. 5." +"5 “The greatest achievement of the human brain”: Gilbert, p. 5. + +6 “area 10 (the internal granular layer IV)”: Gazzaniga, p. 20. + +7 The male gets confused, because it wants: Eagleman, p. 144. + +8 “I predict that mirror neurons”: Brockman, p. xiii. + +9 Biologist Carl Zimmer writes: Bloom, p. 51. + +10 “Most of the time we daydream”: Bloom, p. 51. + +Ill asked one person who may: Interview with Dr. Michael Gazzaniga +in September 2012 for Science Fantastic national radio broadcast. + +12 “It is the left hemisphere”: Gazzaniga, p. 85. + +CHAPTER 3: TELEPATHY—A PENNY FOR YOUR THOUGHTS + +1 Indeed, in a recent “Next 5 in 5”: http://www.ibm.com/5in5. + +2 I had the pleasure of touring: Interview with Dr. Gallant on July 11, + + 2012, at the University of California, Berkeley. Also, interview with +Dr. Gallant on Science Fantastic for national radio, July 2012. + +3 “This is a major leap forward”: Berkeleyan Newsletter, September +22, 2011, http://newscenter.berkeley.edu/2011/09/22/brain-movies." +"4 “If you take 200 voxels”: Brockman, p. 236. + +5 Dr. Brian Pasley and his colleagues: Visit to Dr. Pasley’s laboratory +on July 11, 2012, at the University of California, Berkeley. + +6 Similar results were obtained: The Brain Institute, University of +Utah, Salt Lake City, http://brain.utah.edu. + +7 This could have applications for artists: http://io9/543338/a- +device-that-lets-io9.com/543338/a-device-that-lets-ou-type-with-your- +mind. + +8 According to their officials: http://news.discovery.com/tech/type- +with-your-mind-110309.html. + +9 being explored by Dr. David Poeppel: Discover Magazine Presents the +Brain, Spring 2012, p. 43. + +10 In 1993 in Germany: Scientific American, November 2008, p. 68. + +11 The only justification for its existence: Garreau, pp. 23-24. + +12 I once had lunch with: Symposium on the future of science +sponsored by the Science Fiction Channel at the Chabot Pace and +Science Center, Oakland, California, in May 2004." +"13 On another occasion: Conference in Anaheim, California, April +2009. + +14 He says, “Imagine if soldiers”: Garreau, p. 22. + +15 “What he is doing is spending”: Ibid., p. 19. + +16 When I asked Dr. Nishimoto: Visit to Dr. Gallant’s laboratory at the +University of California, Berkeley, on July 11, 2012. + +17 “There are ethical concerns”: http://www.nbcnews.com/ +id/47447302/ns/health-health_care/t/paralyzed-woman-gets-robotic- +arm.html. + +CHAPTER 4: TELEKINESIS: MIND CONTROLLING MATTER + + 1 “I would love to have”: New York Times, May 17, 2012, p. A17 and +http://www.msnbc.mns.eom/id/47447302/ns/health-health_care/t/ +parallyzed-woman-gets-robotic-arm.html. + +2 “We have taken a tiny sensor”: Interview with Dr. John Donoghue in +November 2009 for Science Fantastic national radio broadcast. + +3 In the United States alone, more than two hundred thousand: + +Centers for Disease Control and Prevention, Washington, D.C. http:// +www. ede. go v/traumatiebraininj ury/scifacts. html ." +"4 When the monkey wanted to move: + +http://physio.northwestern.edu/faculty/miller.htm; http://www. + +northwestern.edu/newscenter/stories/2012/04/miller-paralyzed- + +technology.html. + +5 “We are eavesdropping on the natural”: http://www.northwestern. +edu/newscenter/stories/2012/04/miller-paralyzed-technology.html. + +6 More than 1,300 service members: http://www.darpa.mil/Our_ +Work/DSO/Programs/Revolutionizing_Prosthetics.aspx. CBS 60 +Minutes, broadcast on December 30, 2012. + +7 “They thought we were crazy”: Ibid. + +8 she appeared on 60 Minutes: Ibid. + +9 “There’s going to be a whole ecosystem”: Wall Street Journal, May +29, 2012. + +10 But perhaps the most novel applications: Interview with Dr. +Nicolelis in April 2011 for Science Fantastic national radio broadcast." +"11 Smart Hands and Mind Melds: New York Times, March 13, 2013, +http://nytimes.com/2013/03/01/science/new-research-suggests-two- +rat-brains-can-be-linked. See also Huffington Post, February 28, 2013, +http://www.huffingtonpost.com/2013/02/28/mind-melds-brain- +communication_n_2781609.html. + +12 In 2013, the next important step: USA Today, August 8, 2013, p. +ID. + + 13 About ten years ago: Interview with Dr. Nicolelis in April 2011. + +14 “so there’s nothing sticking out”: For a full discussion of the +exoskeleton, see Nicolelis, pp. 303-7. + +15 The Honda Corporation has: http://www.asimo.honda.com. Also, +interview with the creators of ASIMO in April 2007 for the BBC-TV +series Visions of the Future. + +16 Eventually, you get the hang: http://discovermagazine.com/2007/ +may/re vie w-test- driving- the -future . + +17 Then, by thinking, the patient: Discover, December 9, 2011, http:// +discovermagazine.com/2011/dec/09-mind-over-motor-controlling- +robots-with-your-thoughts." +"18 “We will likely be able to operate”: Nicolelis, p. 315. + +19 I saw a demonstration of this: Interview with the scientists at +Carnegie Mellon in August 2010 for the Discovery/Science Channel TV +series Sci Fi Science. + +CHAPTER 5: MEMORIES AND THOUGHTS MADE TO ORDER + +1 “It has all come together”: Wade, p. 89. + +2 So far, scientists have identified: Ibid., p. 91. + +3 For instance, Dr. Antonio Damasio: Damasio, pp. 130-53. + +4 One fragment of memory might: Wade, p. 232. + +5 “If you can’t do it”: http://www.newscientist.com/article/dn3488. + +6 “Turn the switch on”: http://www.eurekalert.org/pub_releases/2011- +06/uosc-rmr06211 .php. + +7 “Using implantables to enhance competency”: http://hplus +magazine.com/2009/03/18/artificial-hipppocampus. + +8 Not surprisingly, with so much at stake: http://articles. +washingtonpost.com/2013-07-12/national/40863765_l_brain-cells- +mice-new-memories." +"9 If encoding the memory: This brings up the question of whether +carrier pigeons, migratory birds, whales, etc., have a long-term +memory, given that they can migrate over hundreds to thousands of + + miles in search of feeding and breeding grounds. Science knows little +about this question. But it is believed that their long-term memory is +based on locating certain landmarks along the way, rather than +recalling elaborate memories of past events. In other words, they do +not use memory of past events to help them simulate the future. Their +long-term memory consists of just a series of markers. Apparently, +only in humans are long-term memories used to help simulate the +future. + +10 “The purpose of memory is”: Michael Lemonick, “Your Brain: A +User’s Guide,” Time, December 2011, p. 78. + +11 “You might look at it”: http://sciencedaily.com/videos/2007/0210- +brain_scans_of_the_future.htm. + +12 their study proves a “tentative answer”: http://www.sciencedaily. +com/videos/2007/0710." +"12 their study proves a “tentative answer”: http://www.sciencedaily. +com/videos/2007/0710. + +13 “The whole idea is that the device”: New York Times, September + +12, 2012, p. A18. + +14 “It will likely take us”: http://www.tgdaily.com/general-sciences- +features/58736-artificial-cerebellum-restores-rats. + +15 There are 5.3 million Americans: Alzheimer’s Foundation of +America, http://www.alzfdn.org. + +16 “This adds to the notion”: ScienceDaily.com, October 2009, http:// +www.sciencedaily.com/releases/2009/10/091019122647.htm. + +17 “We can never turn it into”: Ibid. + +18 “This implies these flies have”: Wade, p. 113. + +19 This effect is not just restricted: Ibid. + +20 “We can now give you”: Ibid., p. 114. + +21 Basically, the more CREB proteins: Bloom, p. 244. + +22 “Propranolol sits on that nerve cell”: SATI e-News, June 28, 2007, +http://www.mysati.com/enews/June2007/ptsd.htm. + +23 Its report concluded: Boleyn-Fitzgerald, p. 104. + +24 “Our breakups, our relationships”: Ibid." +"23 Its report concluded: Boleyn-Fitzgerald, p. 104. + +24 “Our breakups, our relationships”: Ibid. + + 25 “should we deprive them of morphine”: Ibid., p. 105. + +26 “If further work confirms this view”: Ibid., p. 106. + +27 “Each of these perennial records”: Nicolelis, p. 318. + +28 “Forgetting is the most beneficial process”: New Scientist, March +12, 2003, http://www.newscientists.com/article/dn3488. + +CHAPTER 6: EINSTEIN’S BRAIN AND ENHANCING INTELLIGENCE + +1 “got caught up in the moment”: + +http://abcnews.go.com/blogs/headlines/2012/03/einsteins-brain- + +arrives-in-london-after-odd-journey. + +2 “I have always maintained that”: Gould, p. 109. + +3 “The human brain remains ‘plastic’ ”: www.sciencedaily.com/ +releases/2011/12/111208257120.htm. + +4 “The emerging picture from such studies”: Gladwell, p. 40. + +5 Five years later, Terman started: See C. K. Holahan and R.R. Sears, +The Gifted Group in Later Maturity (Stanford, CA: Stanford University +Press, 1995)." +"6 “Your grades in school”: Boleyn-Fitzgerald, p. 48. + +7 “Tests don’t measure motivation”: Sweeney, p. 26. + +8 The pilots who scored highest: Bloom, p. 12. + +9 “The left hemisphere is responsible”: Ibid., p. 15. + +10 Dr. Darold Treffert, a Wisconsin physician: http://www.darold +treffert.com. + +11 It took him just forty-five seconds: Tammet, p. 4. + +12 I had the pleasure of interviewing: Interview with Mr. Daniel +Tammet in October 2007 for Science Fantastic national radio broadcast. + +13 “Our study confirms”: Science Daily, March 2012, http://www. +sciencedaily.com/releases/2012/03/120322100313.htm. + + 14 Kim Peek’s brain: AP wire story, November 8, 2004, http://www. +Space.com. + +15 In 1998 , Dr. Bruce Miller: Neurology 51 (October 1998): pp. 978- +82. See also http://www.wisconsinmedicalsociety.org/savant_ +syndrome/savant-articles/acquired_savant. + +16 In addition to the savants: Sweeney, p. 252." +"16 In addition to the savants: Sweeney, p. 252. + +17 This idea has actually been tried: Center of the Mind, Sydney, +Australia, http://www.centerofthemind.com. + +18 In another experiment, Dr. R. L. Young: R. L. Young, M. C. +Ridding, and T. L. Morrell, “Switching Skills on by Turning Off Part of +the Brain,” Neurocase 10 (2004): 215, 222. + +19 “When applied to the prefrontal lobes”: Sweeney, p. 311. + +20 Until recently, it was thought: Science Daily, May 2012, http:// +www.sciencedaily.com/releases/2012/05/120509180113.htm. + +21 “Savants have a high capacity”: Ibid. + +22 In 2007 , a breakthrough occurred: Sweeney, p. 294. + +23 “Stem cell research and regenerative medicine”: Sweeney, p. 295. + +24 Scientists have focused on a few genes: Katherine S. Pollard, +“What Makes Us Different,” Scientific American Special Collectors Edition +(Winter 2013): 31-35. + +25 “I jumped at the opportunity”: Ibid. + +26 “With my mentor David Haussler”: Ibid." +"25 “I jumped at the opportunity”: Ibid. + +26 “With my mentor David Haussler”: Ibid. + +27 One such gene was discovered: TG Daily, November 15, 2012. +http://www.tgdaily.com/general-sciences-features/67503-new-found- +gene-separates-man-from-apes. + +28 Many theories have been proposed: See, for example, Gazzaniga, +Human: The Science Behind What Makes Us Unique. + +29 “For the first few hundred million years”: Gilbert, p. 15. + +30 “Cortical gray matter neurons are working”: Douglas Fox, “The +Limits of Intelligence,” Scientific American, July 2011, p. 43. + +31 “You might call it the mother”: Ibid., p. 42. + + CHAPTER 7: IN YOUR DREAMS + +1 He followed this up with one thousand: C. Hall and R. Van de + +Castle, The Content Analysis of Dreams (New York: Appleton-Century- +Crofts, 1966). + +2 When I interviewed him, he told me: Interview with Dr. Allan +Hobson in July 2012 for Science Fantastic national radio broadcast. + +3 Studies have shown that it is possible: Wade, p. 229." +"3 Studies have shown that it is possible: Wade, p. 229. + +4 ATR chief scientist Yukiyasu Kamitani: New Scientist, December 12, + +2008, http://www.newscientist.com/article/dnl 6267-mindreading- + +software-could-record-your-dreams.html#.UvE9P0Qi07s. + +5 When I visited the laboratory: Visit to Dr. Gallant’s laboratory on +July 11, 2012. + +6 “Our dreams are therefore not”: Science Daily, October 28, 2011, +http://www.sciencedaily.com/releases/2011/10/111028113626.htm. + +7 Already, prototypes of Internet contact lenses: See the work of Dr. +Babak Parviz, http://www.wearable-technologies.com/262. + +CHAPTER 8: CAN THE MIND BE CONTROLLED? + +1 A raging bull is released: Miguel Nicolelis, Beyond Boundaries (New +York: Henry Holt, 2011), pp. 228-32. + +2 The cold war hysteria eventually reached: “Project MKUltra, the" +"2 The cold war hysteria eventually reached: “Project MKUltra, the + +CIA’s Program of Research into Behavioral Modification. Joint +Hearings Before the Select Committee on Human Resources, U.S. +Senate, 95th Congress, First Session,” Government Printing Office, +August 8, 1977, Washington, D.C., http://www.nytimes.com/ + +packages/pdf/national/13inmate_ProjectMKULTRA.pdf; “CIA Says It +Found More Secret Papers on Behavior Control,” New York Times, +September 3, 1977; “Government Mind Control Records of MKUltra +and Bluebird/Artichoke,” http://wanttoknow.info/mindcontrol.shtml; +“The Select Committee to Study Governmental Operations with" +"Respect to Intelligence Activities, Foreign and Military Intelligence.” +The Church Committee Report No. 94-755, 94th Congress, 2nd +Session, p. 392, Government Printing Office, Washington, D.C., 1976; +“Project MKUltra, the CIA’s Program of Research in Behavior +Modification,” http://scribd.com/doc/75512716/Project-MKUltra- +The-CIA-s-Program-of-Research-in-Behavior-Modification. + +3 “great potential for development”: Rose, p. 292. + +4 “neuro-scientific impossibility”: Ibid., p. 293. + +5 “It is probably significant that”: “Hypnosis in Intelligence,” Black +Vault Freedom of Information Act Archive, 2008, http://documents. +theblackvault.com/documents/mindcontrol/hypnosisinintelligence. +pdf. + +6 To see how widespread this problem: Boleyn-Fitzgerald, p. 57. + +7 Drugs like LSD: Sweeney, p. 200. + +8 “This is the first time we’ve shown”: Boleyn-Fitzgerald, p. 58. + +9 “If you want to turn off”: http://www.nytimes.com/2011/05/17/ +science/17optics.html." +"9 “If you want to turn off”: http://www.nytimes.com/2011/05/17/ +science/17optics.html. + +10 “By feeding information from sensors”: New York Times, March 17, +2011, http://nytimes.com/2011/05/17/science/17optics.html. + +CHAPTER 9: ALTERED STATES OF CONSCIOUSNESS + +1 “Some fraction of history’s prophets”: Eagleman, p. 207. + +2 “Sometimes it’s a personal God”: Boleyn-Fitzgerald, p. 122. + +3 “ ‘Finally, I see what it is’ ”: Ramachandran, p. 280. + +4 “During the three minute bursts”: David Biello, Scientific American, +p. 41, www.sciammind.com. + +5 To test these ideas: Ibid., p. 42. + +6 “Although atheists might argue”: Ibid., p. 45. + +7 “If you are an atheist”: Ibid., p. 44. + +8 One theory holds that Parkinson’s: Sweeney, p. 166. + + 9 “Neurons wired for the sensation”: Ibid., p. 90. + +10 “The brain’s gonna do what”: Ibid., p. 165. + +11 “Brain scans have led researchers”: Ibid., p. 208. + +12 “If left unchecked, the left hemisphere”: Ramachandran, p. 267. + +13 Underactivity in this area: Carter, pp. 100-103." +"13 Underactivity in this area: Carter, pp. 100-103. + +14 Ten percent of them, in turn: Baker, pp. 46-53. + +15 “Depression 1.0 was psychotherapy”: Ibid., p. 3. + +16 One to three percent of DBS patients: Carter, p. 98. + +17 “The calcium channels findings suggest”: New York Times, + +February 26, 2013, http://www.nytimes.com/2013/03/01/ + +health/study-finds-genetic-risk-factors-shared-by-5-psychiatric- +disorders.html. + +18 “What we have identified here”: Ibid. + +CHAPTER 10: THE ARTIFICIAL MIND AND SILICON CONSCIOUSNESS + +1 “Machines will be capable”: Crevier, p. 109. + +2 “within a generation ... the problem”: Ibid. + +3 “It’s as though a group of people”: Kaku, p. 79. + +4 “I would pay a lot for a robot”: Brockman, p. 2. + +5 However, I met privately with: Interview with the creators of ASIMO +during a visit to Honda’s laboratory in Nagoya, Japan, in April 2007 +for the BBC-TV series Visions of the Future." +"6 he used to marvel at the mosquito: Interview with Dr. Rodney +Brooks in April 2002 for Exploration national radio broadcast. + +7 I have had the pleasure of visiting: Visit to MIT Media Laboratory +for the Discovery/Science Channel TV series Sci Fi Science, April 13, +2010 . + +8 “That is why Breazeal decided”: Moss, p. 168. + + 9 At Waseda University: Gazzaniga, p. 352. + +10 Their goal is to integrate: Ibid., p. 252. + +11 Meet Nao: Guardian, August 9, 2010, http://www.theguardian.com/ +technology/2010/aug/09/nao-robot-develop-display-emotions. + +12 “It’s hard to predict the future”: http://cosmomagazine.com/news/ +4177/reverse-engineering-brain. + +13 Neuroscientists like Dr. Antonio Damasio: Damasio, pp. 108-29. + +14 “In mathematics, you don’t understand”: Kurzweil, p. 248. + +15 “There could not be an objective test”: Pinker, “The Riddle of +Knowing You’re Here,” Your Brain: A User’s Guide, Winter, 2011, p. 19. + +16 At Meiji University: Gazzaniga, p. 352." +"16 At Meiji University: Gazzaniga, p. 352. + +17 “To our knowledge, this is the first”: Kurzweil.net, August 24, + +2012, http://www.kurzweilai.net/robot-learns-self-awareness. See also +Yale Daily News, September 25, 2012, + +http://yaledailynews.com/blog/2012/09/25/first-self-aware-robot- +created. + +18 When I interviewed Dr. Hans Moravec: Interview with Dr. Hans +Moravec in November 1998 for Exploration national radio broadcast. + +19 “Unleashed from the plodding pace”: Sweeney, p. 316. + +20 When I interviewed Dr. Rodney Brooks: Interview with Dr. Brooks +in April 2002 for Exploration national radio broadcast. + +21 “We don’t like to give up”: TEDTalks, http://www.ted.com/talks/ +lang/en/rodney_brooks_on_robots.html. + +22 Similarly, at the University of Southern California: http://phys. +org/news205059692.html. + +CHAPTER 11: REVERSE ENGINEERING THE BRAIN + +1 Almost simultaneously, the European Commission: http://actu. +epfl.ch/news/the-human-brain-project-wins-top-european-science." +"2 “It’s essential for us to understand”: + +http://blog.ted.eom/2009/l 0/15/supercomputing. + +3 “There’s not a single neurological disease”: Kushner, p. 19. + +4 “I think we’re far from playing God”: Ibid., p. 2. + +5 “In a hundred years, I’d like”: Sally Adee, “Reverse Engineering the +Brain,” IEEE Spectrum, http://spectrum.ieee.org/biomedical/ethics/ +reverse-engineering-the-brain. + +6 “Researchers have conjectured”: + +http://www.cnn.corn/2012/03/01/tech/innovation/brain-map- + +connectome. + +“In the seventeenth century”: + +http: //www. ted. com/talks/lang/en/sebastian_seung .html . + +8 “The Allen Human Brain Atlas provides”: http://ts-si.org/ +neuroscience/29735-allen-human-brain-atlas-updates-with- +comprehensive). + +9 According to Dr. V. S. Ramachandran: TED Talks, January 2010, +http://www.ted.com. + +CHAPTER 12: THE FUTURE: MIND BEYOND MATTER + +1 5.8 percent claimed they had an out-of-body: Nelson, p. 137. + +2 “I see myself lying in bed”: Ibid., p. 140." +"2 “I see myself lying in bed”: Ibid., p. 140. + +3 Notably, temporary loss of blood: National Geographic News, April 8, +2010, http://news.nationalgeographic.eom/news/2010/04/100408- +near-death-experiences-blood-carbon-dioxide; Nelson, p. 126 + +4 Dr. Thomas Lempert, neurologist: Nelson, p. 126. + +5 The U.S. Air Force, for example: Ibid., p. 128. + +6 We once spoke at a conference: Dubai, United Arab Emirates, +November 2012. Interviewed in February 2003 for Exploration +national radio broadcast. Interviewed in October 2012 for Science + + Fantastic national radio broadcast. + +7 By 2055, $1,000 of computing power: Bloom, p. 191. + +8 For example, Bill Gates, cofounder: Sweeney, p. 298. + +9 “People who predict a very utopian future”: Carter, p. 298. + +10 He told me that the San Diego Zoo: Interview with Dr. Robert +Lanza in September 2009 for Exploration national radio broadcast. + +11 “Should we ridicule the modern seekers”: Sebastian Seung, +TEDTalks, http://www.ted.com/talks/lang/en/sebastian_seung.html ." +"12 In 2008, BBC-TV aired: http://www.bbc.co.uk/sn/tvradio/ +programmes/horizon/broadband/tx/isolation/timeline. + +13 we will be able to reverse engineer: Interview with Dr. Moravec in +November 1998 for Exploration national radio broadcast. + +14 On the other side was Eric Drexler: See a series of letter in +Chemical and Engineering News from 2003 to 2004. + +15 “I’m not planning to die”: Garreau, p. 128. + +CHAPTER 13: THE MIND AS PURE ENERGY + +1 “Wormholes, extra dimensions”: Sir Martin Rees, Our Final Hour +(New York: Perseus Books, 2003), p. 182. + +CHAPTER 14: THE ALIEN MIND + +1 So far, more than one thousand: Kepler Web Page, http://kepler. +nasa.gov. + +2 In 2013, NASA scientists announced: Ibid. + +3 how they can distinguish false messages: Interview with Dr. +Wertheimer in June 1999 for Exploration national radio broadcast. + +4 I once asked him about the giggle factor: Interview with Dr. Seth +Shostak in May 2012 for Science Fantastic national radio broadcast. + +5 He has gone on record: Ibid." +"5 He has gone on record: Ibid. + + 6 “Remember, this is the same government”: Davies, p. 22. + +7 The Greek writers: Sagan, p. 221. + +8 But St. Thomas Aquinas: Ibid. + +9 We can be fooled: Ibid. + +10 “If the fact that brutes abstract”: Ibid., p. 113. + +11 “In the blind and deaf world”: Eagleman, p. 77. + +12 we have to expand our own horizon: Interview with Dr. Paul +Davies in April 2012 for Science Fantastic national radio broadcast. + +13 “My conclusion is a startling one”: Davies, p. 159. + +14 “Although there is only a tiny probability”: Discovery News, +December 27, 2011, http://news.discovery.com/space/seti-to-scour- +the-moon-for-alien-tech-111227.htm. + +CHAPTER 15: CONCLUDING REMARKS + +1 In an article in Wired: Wired, April 2000, http://www.wired.com/ +wired/archive/8.04/joy.html. + +2 “several separate and unequal species”: Garreau, p. 139. + +3 “This techno utopia is all about”: Ibid., p. 180. + +4 “The idea that we are messin’ ”: Ibid., p. 353. + +5 “Technologies—such as gunpowder”: Ibid., p. 182." +"5 “Technologies—such as gunpowder”: Ibid., p. 182. + +6 “The you that all your friends know”: Eagleman, p. 205. + +7 “Our reality depends on what”: Ibid., p. 208. + +8 “How it is that anything so remarkable”: Pinker, p. 132. + +9 somehow create a twin of the Earth: Interview with Dr. Stephen Jay +Gould in November 1996 for Exploration national radio broadcast. + +10 “ Homo sapiens is one small twig”: Pinker, p. 133. + +11 “nothing gives life more purpose”: Pinker, “The Riddle of Knowing +You’re Here,” Time: Your Brain: A User’s Guide (Winter 2011), p. 19. + + 12 “What a perplexing masterpiece”: Eagleman, p. 224. + +APPENDIX: QUANTUM CONSCIOUSNESS? + +1 many (but not all) pathological killers: Interview with Dr. Simon +Baron-Cohen in July 2005 for Exploration national radio broadcast. + +2 Dr. Michael Sweeney concludes, “Libet’s findings”: Sweeney, p. +150. + +SUGGESTED READING + +Baker, Sherry. “Helen Mayberg.” Discover Magazine Presents the Brain. +Waukesha, WI: Kalmbach Publishing Co., Fall 2012." +"Bloom, Floyd. Best of the Brain from Scientific American: Mind, Matter, and +Tomorrow’s Brain. New York: Dana Press, 2007. + +Boleyn-Fitzgerald, Miriam. Pictures of the Mind: What the New +Neuroscience Tells Us About Who We Are. Upper Saddle River, N.J.: +Pearson Education, 2010. + +Brockman, John, ed. The Mind: Leading Scientists Explore the Brain, +Memory, Personality, and Happiness. New York: Harper Perennial, 2011. + +Calvin, William H. A Brief History of the Mind. New York: Oxford +University Press, 2004. + +Carter, Rita. Mapping the Mind. Berkeley: University of California Press, +2010 . + +Crevier, Daniel. AT. The Tumultuous History of the Search for Artificial +Intelligence. New York: Basic Books, 1993. + +Crick, Francis. The Astonishing Hypothesis: The Science Search for the Soul. +New York: Touchstone, 1994. + +Damasio, Antonio. Self Comes to Mind: Constructing the Conscious Brain. +New York: Pantheon Books, 2010." +"Davies, Paul. The Eerie Silence: Renewing Our Search for Alien Intelligence. +New York: Houghton Mifflin Harcourt, 2010. + +Dennet, Daniel C. Breaking the Spell: Religion as a Natural Phenomenon. +New York: Viking, 2006. + + -. Conscious Explained. New York: Back Bay Books, 1991. + +DeSalle, Rob, and Ian Tattersall. The Brain: Big Bangs, Behaviors, and +Beliefs. New Haven, CT: Yale University Press, 2012. + +Eagleman, David. Incognito: The Secret Lives of the Brain. New York: + +Pantheon Books, 2011. + +Fox, Douglas. “The Limits of Intelligence,” Scientific American, July 2011. + +Garreau, Joel. Radical Evolution: The Promise and Peril of Enhancing Our +Minds , Our Bodies—and What It Means to Be Human. New York: +Random House, 2005. + +Gazzaniga, Michael S. Human: The Science Behind What Makes Us Unique. +New York: HarperCollins, 2008. + +Gilbert, Daniel. Stumbling on Happiness. New York: Alfred A. Knopf, + +2006. + +Gladwell, Malcolm. Outliers: The Story of Success. New York: Back Bay +Books, 2008." +"2006. + +Gladwell, Malcolm. Outliers: The Story of Success. New York: Back Bay +Books, 2008. + +Gould, Stephen Jay. The Mismeasure of Man. New York: W. W. Norton, +1996. + +Horstman, Judith. The Scientific American Brave New Brain. San +Francisco: John Wiley and Sons, 2010. + +Kaku, Michio. Physics of the Future. New York: Doubleday, 2009. + +Kurzweil, Ray. How to Create a Mind: The Secret of Human Thought +Revealed. New York: Viking Books, 2012. + +Kushner, David. “The Man Who Builds Brains.” Discover Magazine +Presents the Brain. Waukesha, WI: Kalmbach Publishing Co., Fall 2001. + +Moravec, Hans. Mind Children: The Future of Robot and Human +Intelligence. Cambridge, MA: Harvard University Press, 1988. + +Moss, Frank. The Sorcerers and Their Apprentices: How the Digital +Magicians of the MIT Media Lab Are Creating the Innovative Technologies +That Will Transform Our Lives. New York: Crown Business, 2011. + + Nelson, Kevin. The Spiritual Doorway in the Brain. New York: Dutton, +2011." +"Nelson, Kevin. The Spiritual Doorway in the Brain. New York: Dutton, +2011. + +Nicolelis, Miguel. Beyond Boundaries: The New Neuroscience of Connecting +Brains with Machines—and How It Will Change Our Lives. New York: +Henry Holt and Co., 2011. + +Pinker, Steven. How the Mind Works. New York: W. W. Norton, 2009. + +-. The Stuff of Thought: Language as a Window into Human + +Nature. New York: Viking, 2007. + +-. “The Riddle of Knowing You’re Here.” In Your Brain: A + +User’s Guide. New York: Time Inc. Specials, 2011. + +Piore, Adam. “The Thought Helmet: The U.S. Army Wants to Train +Soldiers to Communicate Just by Thinking.” The Brain, Discover +Magazine Special, Spring 2012. + +Purves, Dale, et al., eds. Neuroscience. Sunderland, MA: Sinauer +Associates, 2001. + +Ramachandran, V. S. The Tell-Tale Brain: A Neuroscientist’s Quest for What +Makes Us Human. New York: W. W. Norton, 2011." +"Rose, Steven. The Future of the Brain: The Promise and Perils of Tomorrow’s +Neuroscience. Oxford, UK: Oxford University Press, 2005. + +Sagan, Carl. The Dragons of Eden: Speculations on the Evolution of Human +Intelligence. New York: Ballantine Books, 1977. + +Sweeney, Michael S. Brain: The Complete Mind: How It Develops, How It +Works, and How to Keep It Sharp. Washington, D.C.: National +Geographic, 2009. + +Tammet, Daniel. Bom on a Blue Day: Inside the Extraordinary Mind of an +Autistic Savant. New York: Free Press, 2006. + +Wade, Nicholas, ed. The Science Times Book of the Brain. New York: New +York Times Books, 1998. + +ILLUSTRATION CREDITS + + 1.1 Jeffrey L. Ward + +1.2 Jeffrey L. Ward + +1.3 Jeffrey L. Ward + +1.4 Jeffrey L. Ward + +1.5 AP Photo / David Duprey + +1.5a Tom Barrick, Chris Clark / Science Source + +1.6 Jeffrey L. Ward + +2.1 Jeffrey L. Ward + +2.2 Jeffrey L. Ward + +2.3 Jeffrey L. Ward + +4.1 The Laboratory of Dr. Miguel Nicolelis, Duke University + +5.1 Jeffrey L. Ward" +"4.1 The Laboratory of Dr. Miguel Nicolelis, Duke University + +5.1 Jeffrey L. Ward + +10.1 MIT Media Lab, Personal Robots Group + +10.2 MIT Media Lab, Personal Robots Group, Mikey Siegel + +A Note About the Author + +MICHIO KAKU is a professor of theoretical physics at the City College +and City University of New York; cofounder of string field theory; the +author of several widely acclaimed science books, including Hyperspace, +Beyond Einstein, Physics of the Impossible, and Physics of the Future; and +host of numerous TV specials and a national science radio show. + +Other titles by Michio Kaku available in eBook format +Parallel Worlds • 9780385514163 +Physics of the Future • 9780385530811 +Physics of the Impossible • 9780385525442 + +Visions • 9780307794772 + +Visit mkaku.org + +For more information on Doubleday books + + Visit: www.doubleday.com +Like: facebook.com/DoubledayBooks +Follow: @doubledaypub + +ALSO BY THE AUTHOR + +Physics of the Future +Physics of the Impossible +Parallel Worlds +Hyperspace +Visions" +"Physics of the Future +Physics of the Impossible +Parallel Worlds +Hyperspace +Visions + +Einstein’s Cosmos +Beyond Einstein" +"DR. MICHIO KAMI + +PROFESSOR OF THEORETICAL PHYSICS +CITY UNIVERSITY OI : NEW YORK + +THE SCIENTIFIC QUEST TO UNDERSTAND +ENHANCE, AND EMPOWER THE MIND + +DOUBLEPAY + +NEW YORK LONDON TORONTO + +SYDNEY AUCKLAND + +Copyright © 2014 by Michio Kaku + +All rights reserved. Published in the United States by Doubleday, a division of Random House, +LLC, New York, and in Canada by Random House of Canada Limited, Toronto, Penguin Random +House companies. + +www.doubleday.com + +doubleday and the portrayal of an anchor with a dolphin are registered trademarks of Random +House, LLC. + +Illustrations by Jeffrey L. Ward +Jacket design by Michael J. Windsor + + Jacket illustration © CLIP AREA/Custom media/Shutterstock +LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA +Kaku, Michio. + +The future of the mind : the scientific quest to understand, enhance, and empower the mind / +Dr. Michio Kaku, professor of Theoretical Physics, City University of New York. — First edition, +pages cm + +Includes bibliographical references." +"Includes bibliographical references. + +1. Neuropsychology. 2. Mind and body—Research. + +3. Brain—Mathematical models. 4. Cognitive neuroscience. + +5. Brain-computer interfaces. I. Title. +qp360.k 325 2014 +612.8—dc23 + +2013017338 + +ISBN 978-0-385-53082-8 (hardcover) ISBN 978-0-385-53083-5 (eBook) + +v3.1 + +This book is dedicated to my loving wife, Shizue, + +and my daughters, Michelle and Alyson + +CONTENTS + +Cover + +Title Page + +Copyright + +Dedication + +ACKNOWLEDGMENTS + +INTRODUCTION + + BOOK I: THE MIND AND CONSCIOUSNESS + +1 UNLOCKING THE MIND + +2 CONSCIOUSNESS—A PHYSICIST’S VIEWPOINT + +BOOK II: MIND OVER MATTER + +3 TELEPATHY: A PENNY FOR YOUR THOUGHTS + +4 TELEKINESIS: MIND CONTROLLING MATTER + +5 MEMORIES AND THOUGHTS MADE TO ORDER + +6 EINSTEIN’S BRAIN AND ENHANCING OUR INTELLIGENCE + +BOOK III: ALTERED CONSCIOUSNESS + +7 IN YOUR DREAMS + +8 CAN THE MIND BE CONTROLLED? + +9 ALTERED STATES OF CONSCIOUSNESS + +10 THE ARTIFICIAL MIND AND SILICON CONSCIOUSNESS + +11 REVERSE ENGINEERING THE BRAIN" +"10 THE ARTIFICIAL MIND AND SILICON CONSCIOUSNESS + +11 REVERSE ENGINEERING THE BRAIN + +12 THE FUTURE: MIND BEYOND MATTER + +13 THE MIND AS PURE ENERGY + +14 THE ALIEN MIND + +15 CONCLUDING REMARKS + +APPENDIX: QUANTUM CONSCIOUSNESS? + +NOTES + +SUGGESTED READING +ILLUSTRATION CREDITS +A Note About the Author + +Other Books by This Author + +ACKNOWLEDGMENTS + + It has been my great pleasure to have interviewed and interacted with +the following prominent scientists, all of them leaders in their fields. I +would like to thank them for graciously giving up their time for +interviews and discussions about the future of science. They have given +me guidance and inspiration, as well as a firm foundation in their +respective fields. + +I would like to thank these pioneers and trailblazers, especially those +who have agreed to appear on my TV specials for the BBC, Discovery, +and Science TV channels, and also on my national radio shows, Science +Fantastic and Explorations." +"Peter Doherty, Nobel laureate, St. Jude Children’s Research Hospital + +Gerald Edelman, Nobel laureate, Scripps Research Institute + +Leon Lederman, Nobel laureate, Illinois Institute of Technology + +Murray Gell-Mann, Nobel laureate, Santa Fe Institute and Cal Tech + +the late Henry Kendall, Nobel laureate, MIT + +Walter Gilbert, Nobel laureate, Harvard University + +David Gross, Nobel laureate, Kavli Institute for Theoretical Physics + +Joseph Rotblat, Nobel laureate, St. Bartholomew’s Hospital + +Yoichiro Nambu, Nobel laureate, University of Chicago + +Steven Weinberg, Nobel laureate, University of Texas at Austin + +Frank Wilczek, Nobel laureate, MIT + +Amir Aczel, author of Uranium Wars + +Buzz Aldrin, NASA astronaut, second man to walk on the moon +Geoff Andersen, U.S. Air Force Academy, author of The Telescope + +Jay Barbree, author of Moon Shot + +John Barrow, physicist, Cambridge University, author of Impossibility + +Marcia Bartusiak, author of Einstein’s Unfinished Symphony" +"Marcia Bartusiak, author of Einstein’s Unfinished Symphony + + Jim Bell, Cornell University astronomer + +Jeffrey Bennet, author of Beyond UFOs + +Bob Berman, astronomer, author The Secrets of the Night Sky + +Leslie Biesecker, National Institutes of Health + +Piers Bizony, author of How to Build Your Own Starship + +Michael Blaese, National Institutes of Health + +Alex Boese, founder of Museum of Hoaxes + +Nick Bostrom, transhumanist, Oxford University + +Lt. Col. Robert Bowman, Institute for Space and Security Studies + +Cynthia Breazeal, artificial intelligence, MIT Media Lab + +Lawrence Brody, National Institutes of Health + +Rodney Brooks, director of the MIT Artificial Intelligence Laboratory +Lester Brown, Earth Policy Institute +Michael Brown, astronomer, Cal Tech +James Canton, author of The Extreme Future + +Arthur Caplan, director of the Center for Bioethics at the University of +Pennsylvania" +"Arthur Caplan, director of the Center for Bioethics at the University of +Pennsylvania + +Fritjof Capra, author of The Science of Leonardo +Sean Carroll, cosmologist, Cal Tech +Andrew Chaikin, author of A Man on the Moon +Leroy Chiao, NASA astronaut + +Eric Chivian, International Physicians for the Prevention of Nuclear +War + +Deepak Chopra, author of Super Brain + +George Church, director of Harvard’s Center for Computational +Genetics + +Thomas Cochran, physicist, Natural Resources Defense Council + +Christopher Cokinos, astronomer, author of Fallen Sky + + Francis Collins, National Institutes of Health + +Vicki Colvin, nanotechnologist, University of Texas + +Neal Comins, author of Hazards of Space Travel + +Steve Cook, NASA spokesperson + +Christine Cosgrove, author of Normal at Any Cost + +Steve Cousins, CEO of Willow Garage Personal Robots Program + +Phillip Coyle, former assistant secretary of defense for the U.S. Defense +Department + +Daniel Crevier, AI, CEO of Coreco" +"Daniel Crevier, AI, CEO of Coreco + +Ken Croswell, astronomer, author of Magnificent Universe + +Steven Cummer, computer science, Duke University + +Mark Cutkowsky, mechanical engineering, Stanford University + +Paul Davies, physicist, author of Superforce + +Daniel Dennet, philosopher, Tufts University + +the late Michael Dertouzos, computer science, MIT + +Jared Diamond, Pulitzer Prize winner, UCLA + +Marriot DiChristina, Scientific American + +Peter Dilworth, MIT AI Lab + +John Donoghue, creator of Braingate, Brown University +Ann Druyan, widow of Carl Sagan, Cosmos Studios +Freeman Dyson, Institute for Advanced Study, Princeton University +David Eagleman, neuroscientist, Baylor College of Medicine +John Ellis, CERN physicist + +Paul Erlich, environmentalist, Stanford University +Daniel Fairbanks, author of Relics of Eden + +Timothy Ferris, University of California, author of Coming of Age in the +Milky Way Galaxy + +Maria Finitzo, stem cell expert, Peabody Award winner + + Robert Finkelstein, AI expert" +"Maria Finitzo, stem cell expert, Peabody Award winner + + Robert Finkelstein, AI expert + +Christopher Flavin, World Watch Institute + +Louis Friedman, cofounder of the Planetary Society + +Jack Gallant, neuroscientist, University of California at Berkeley + +James Garwin, NASA chief scientist + +Evelyn Gates, author of Einstein’s Telescope + +Michael Gazzaniga, neurologist, University of California at Santa +Barbara + +Jack Geiger, cofounder, Physicians for Social Responsibility + +David Gelertner, computer scientist, Yale University, University of +California + +Neal Gershenfeld, MIT Media Lab + +Daniel Gilbert, psychologist, Harvard University + +Paul Gilster, author of Centauri Dreams + +Rebecca Goldberg, Environmental Defense Fund + +Don Goldsmith, astronomer, author of Runaway Universe + +David Goodstein, assistant provost of Cal Tech + +J. Richard Gott III, Princeton University, author of Time Travel in +Einstein’s Universe + +Late Stephen Jay Gould, biologist, Harvard University" +"Late Stephen Jay Gould, biologist, Harvard University + +Ambassador Thomas Graham, spy satellites and intelligence gathering + +John Grant, author of Corrupted Science + +Eric Green, National Institutes of Health + +Ronald Green, author of Babies by Design + +Brian Greene, Columbia University, author of The Elegant Universe +Alan Guth, physicist, MIT, author of The Inflationary Universe + + William Hanson, author of The Edge of Medicine + +Leonard Hayflick, University of California at San Francisco Medical +School + +Donald Hillebrand, Argonne National Labs, future of the car +Frank N. von Hippel, physicist, Princeton University + +Allan Hobson, psychiatrist, Harvard University +Jeffrey Hoffman, NASA astronaut, MIT + +Douglas Hofstadter, Pulitzer Prize winner, Indiana University, author +of Godel, Escher, Bach + +John Horgan, Stevens Institute of Technology, author of The End of +Science + +Jamie Hyneman, host of MythBusters + +Chris Impey, astronomer, author of The Living Cosmos + +Robert Irie, AI Lab, MIT" +"Chris Impey, astronomer, author of The Living Cosmos + +Robert Irie, AI Lab, MIT + +P. J. Jacobowitz, PC magazine + +Jay Jaroslav, MIT AI Lab + +Donald Johanson, anthropologist, discoverer of Lucy +George Johnson, New York Times science journalist +Tom Jones, NASA astronaut +Steve Kates, astronomer + +Jack Kessler, stem cell expert, Peabody Award winner +Robert Kirshner, astronomer, Harvard University +Kris Koenig, astronomer + +Lawrence Krauss, Arizona State University, author of Physics of Star +Trek + +Lawrence Kuhn, filmmaker and philosopher, Closer to Truth + +Ray Kurzweil, inventor, author of The Age of Spiritual Machines + +Robert Lanza, biotechnology, Advanced Cell Technologies + +Roger Launius, author of Robots in Space + + Stan Lee, creator of Marvel Comics and Spider-Man + +Michael Lemonick, senior science editor of Time + +Arthur Lerner-Lam, geologist, volcanist + +Simon LeVay, author of When Science Goes Wrong + +John Lewis, astronomer, University of Arizona + +Alan Lightman, MIT, author of Einstein’s Dreams" +"John Lewis, astronomer, University of Arizona + +Alan Lightman, MIT, author of Einstein’s Dreams + +George Linehan, author of Space One + +Seth Lloyd, MIT, author of Programming the Universe + +Werner R. Loewenstein, former director of Cell Physics Laboratory, +Columbia University + +Joseph Lykken, physicist, Fermi National Laboratory + +Pattie Maes, MIT Media Lab + +Robert Mann, author of Forensic Detective + +Michael Paul Mason, author of Head Cases: Stories of Brain Injury and +Its Aftermath + +Patrick McCray, author of Keep Watching the Skies + +Glenn McGee, author of The Perfect Baby + +James McLurkin, MIT, AI Lab + +Paul McMillan, director of Space Watch + +Fulvia Melia, astronomer, University of Arizona + +William Meller, author of Evolution Rx + +Paul Meltzer, National Institutes of Health + +Marvin Minsky, MIT, author of The Society of Minds + +Hans Moravec, author of Robot + +Late Phillip Morrison, physicist, MIT" +"Hans Moravec, author of Robot + +Late Phillip Morrison, physicist, MIT + + Richard Muller, astrophysicist, University of California at Berkeley +David Nahamoo, IBM Human Language Technology +Christina Neal, volcanist + +Miguel Nicolelis, neuroscientist, Duke University + +Shinji Nishimoto, neurologist, University of California at Berkeley + +Michael Novacek, American Museum of Natural History + +Michael Oppenheimer, environmentalist, Princeton University + +Dean Ornish, cancer and heart disease specialist + +Peter Palese, virologist, Mount Sinai School of Medicine + +Charles Pellerin, NASA official + +Sidney Perkowitz, author of Hollywood Science + +John Pike, GlobalSecurity.org + +Jena Pincott, author of Do Gentlemen Really Prefer Blondes? + +Steven Pinker, psychologist, Harvard University +Thomas Poggio, MIT, artificial intelligence +Correy Powell, editor of Discover magazine +John Powell, founder of JP Aerospace" +"Richard Preston, author of Hot Zone and Demon in the Freezer +Raman Prinja, astronomer, University College London + +David Quammen, evolutionary biologist, author of The Reluctant Mr. +Darwin + +Katherine Ramsland, forensic scientist + +Lisa Randall, Harvard University, author of Warped Passages + +Sir Martin Rees, Royal Astronomer of Great Britain, Cambridge +University, author of Before the Beginning + +Jeremy Rifkin, Foundation for Economic Trends +David Riquier, MIT Media Lab +Jane Rissler, Union of Concerned Scientists +Steven Rosenberg, National Institutes of Health + + Oliver Sacks, neurologist, Columbia University +Paul Saffo, futurist, Institute of the Future +Late Carl Sagan, Cornell University, author of Cosmos +Nick Sagan, coauthor of You Call This the Future? + +Michael H. Salamon, NASA’s Beyond Einstein program +Adam Savage, host of MythBusters + +Peter Schwartz, futurist, founder of Global Business Network + +Michael Shermer, founder of Skeptic Society and Skeptic magazine" +"Michael Shermer, founder of Skeptic Society and Skeptic magazine + +Donna Shirley, NASA Mars program + +Seth Shostak, SETI Institute + +Neil Shubin, author of Your Inner Fish + +Paul Shurch, SETI League + +Peter Singer, author of Wired for War + +Simon Singh, author of The Big Bang + +Gary Small, author of iBrain + +Paul Spudis, author of Odyssey Moon Limited + +Stephen Squyres, astronomer, Cornell University + +Paul Steinhardt, Princeton University, author of Endless Universe + +Jack Stern, stem cell surgeon + +Gregory Stock, UCLA, author of Redesigning Humans +Richard Stone, author of NEOs and Tunguska +Brian Sullivan, Hayden Planetarium +Leonard Susskind, physicist, Stanford University +Daniel Tammet, author of Bom on a Blue Day +Geoffrey Taylor, physicist, University of Melbourne +Late Ted Taylor, designer of U.S. nuclear warheads +Max Tegmark, cosmologist, MIT +Alvin Toffler, author of The Third Wave +Patrick Tucker, World Future Society" +"Chris Turney, University of Wollongong, author of Ice, Mud and Blood +Neil de Grasse Tyson, director of Hayden Planetarium +Sesh Velamoor, Foundation for the Future + + Robert Wallace, author of Spycraft + +Kevin Warwick, human cyborgs, University of Reading, UK +Fred Watson, astronomer, author of Stargazer +Late Mark Weiser, Xerox PARC +Alan Weisman, author of The World Without Us + +Daniel Wertheimer, SETI at Home, University of California at Berkeley +Mike Wessler, MIT AI Lab + +Roger Wiens, astronomer, Los Alamos National Laboratory +Author Wiggins, author of The Joy of Physics + +Anthony Wynshaw-Boris, National Institutes of Health +Carl Zimmer, biologist, author of Evolution +Robert Zimmerman, author of Leaving Earth +Robert Zubrin, founder of Mars Society" +"I would also like to thank my agent, Stuart Krichevsky, who has been +at my side all these years and has given me helpful advice about my +books. I have always benefited from his sound judgment. In addition, I +would like to thank my editors, Edward Kastenmeier and Melissa +Danaczko, who have guided my book and provided invaluable editorial +advice. And I would like to thank Dr. Michelle Kaku, my daughter and a +neurology resident at Mount Sinai Hospital in New York, for stimulating, +thoughtful, and fruitful discussions about the future of neurology. Her +careful and thorough reading of the manuscript has greatly enhanced the +presentation and content of this book. + +INTRODUCTION" +"INTRODUCTION + +The two greatest mysteries in all of nature are the mind and the +universe. With our vast technology, we have been able to photograph +galaxies billions of light-years away, manipulate the genes that control +life, and probe the inner sanctum of the atom, but the mind and the +universe still elude and tantalize us. They are the most mysterious and +fascinating frontiers known to science. + +If you want to appreciate the majesty of the universe, just turn your +gaze to the heavens at night, ablaze with billions of stars. Ever since our +ancestors first gasped at the splendor of the starry sky, we have puzzled +over these eternal questions: Where did it all come from? What does it +all mean?" +"To witness the mystery of our mind, all we have to do is stare at +ourselves in the mirror and wonder, What lurks behind our eyes? This +raises haunting questions like: Do we have a soul? What happens to us +after we die? Who am “I” anyway? And most important, this brings us to +the ultimate question: Where do we fit into this great cosmic scheme? As +the great Victorian biologist Thomas Huxley once said, “The question of +all questions for humanity, the problem which lies behind all others and +is more interesting than any of them, is that of the determination of +man’s place in Nature and his relation to the Cosmos.”" +"There are 100 billion stars in the Milky Way galaxy, roughly the same +as the number of neurons in our brain. You may have to travel twenty- +four trillion miles, to the first star outside our solar system, to find an +object as complex as what is sitting on your shoulders. The mind and the +universe pose the greatest scientific challenge of all, but they also share +a curious relationship. On one hand they are polar opposites. One is +concerned with the vastness of outer space, where we encounter strange +denizens like black holes, exploding stars, and colliding galaxies. The +other is concerned with inner space, where we find our most intimate +and private hopes and desires. The mind is no farther than our next + +thought, yet we are often clueless when asked to articulate and explain +it." +"thought, yet we are often clueless when asked to articulate and explain +it. + +But although they may be opposites in this respect, they also have a +common history and narrative. Both were shrouded in superstition and +magic since time immemorial. Astrologers and phrenologists claimed to +find the meaning of the universe in every constellation of the zodiac and +in every bump on your head. Meanwhile, mind readers and seers have +been alternately celebrated and vilified over the years." +"The universe and the mind continue to intersect in a variety of ways, +thanks in no small part to some of the eye-opening ideas we often +encounter in science fiction. Reading these books as a child, I would +daydream about being a member of the Sian, a race of telepaths created +by A. E. van Vogt. I marveled at how a mutant called the Mule could +unleash his vast telepathic powers and nearly seize control of the +Galactic Empire in Isaac Asimov’s Foundation Trilogy. And in the movie +Forbidden Planet, I wondered how an advanced civilization millions of +years beyond ours could channel its enormous telekinetic powers to +reshape reality to its whims and wishes." +"Then when I was about ten, “The Amazing Dunninger” appeared on +TV. He would dazzle his audience with his spectacular magic tricks. His +motto was “For those who believe, no explanation is necessary; for those +who do not believe, no explanation will suffice.” One day, he declared +that he would send his thoughts to millions of people throughout the + + country. He closed his eyes and began to concentrate, stating that he was +beaming the name of a president of the United States. He asked people +to write down the name that popped into their heads on a postcard and +mail it in. The next week, he announced triumphantly that thousands of +postcards had come pouring in with the name “Roosevelt,” the very +same name he was “beaming” across the United States." +"I wasn’t impressed. Back then, the legacy of Roosevelt was strong +among those who had lived through the Depression and World War II, so +this came as no surprise. (I thought to myself that it would have been +truly amazing if he had been thinking of President Millard Fillmore.) + +Still, it stoked my imagination, and I couldn’t resist experimenting +with telepathy on my own, trying to read other people’s minds by +concentrating as hard as I could. Closing my eyes and focusing intently, I +would attempt to “listen” to other people’s thoughts and telekinetically + +move objects around my room. + +I failed." +"move objects around my room. + +I failed. + +Maybe somewhere telepaths walked the Earth, but I wasn’t one of +them. In the process, I began to realize that the wondrous exploits of +telepaths were probably impossible—at least without outside assistance. +But in the years that followed, I also slowly learned another lesson: to +fathom the greatest secrets in the universe, one did not need telepathic +or superhuman abilities. One just had to have an open, determined, and +curious mind. In particular, in order to understand whether the fantastic +devices of science fiction are possible, you have to immerse yourself in +advanced physics. To understand the precise point when the possible +becomes the impossible, you have to appreciate and understand the laws +of physics." +"These two passions have fired up my imagination all these years: to +understand the fundamental laws of physics, and to see how science will +shape the future of our lives. To illustrate this and to share my +excitement in probing the ultimate laws of physics, I have written the +books Hyperspace , Beyond Einstein, and Parallel Worlds. And to express +my fascination with the future, I have written Visions, Physics of the +Impossible, and Physics of the Future. Over the course of writing and +researching these books, I was continually reminded that the human +mind is still one of the greatest and most mysterious forces in the world. + +Indeed, we’ve been at a loss to understand what it is or how it works +for most of history. The ancient Egyptians, for all their glorious +accomplishments in the arts and sciences, believed the brain to be a +useless organ and threw it away when embalming their pharaohs." +"Aristotle was convinced that the soul resided in the heart, not the brain, +whose only function was to cool down the cardiovascular system. +Others, like Descartes, thought that the soul entered the body through +the tiny pineal gland of the brain. But in the absence of any solid +evidence, none of these theories could be proven. + +This “dark age” persisted for thousands of years, and with good +reason. The brain weighs only three pounds, yet it is the most complex +object in the solar system. Although it occupies only 2 percent of the +body’s weight, the brain has a ravenous appetite, consuming fully 20 +percent of our total energy (in newborns, the brain consumes an +astonishing 65 percent of the baby’s energy), while fully 80 percent of + +our genes are coded for the brain. There are an estimated 100 billion +neurons residing inside the skull with an exponential amount of neural +connections and pathways." +"Back in 1977, when the astronomer Carl Sagan wrote his Pulitzer +Prize-winning book, The Dragons of Eden, he broadly summarized what +was known about the brain up to that time. His book was beautifully +written and tried to represent the state of the art in neuroscience, which +at that time relied heavily on three main sources. The first was +comparing our brains with those of other species. This was tedious and +difficult because it involved dissecting the brains of thousands of +animals. The second method was equally indirect: analyzing victims of +strokes and disease, who often exhibit bizarre behavior because of their +illness. Only an autopsy performed after their death could reveal which +part of the brain was malfunctioning. Third, scientists could use +electrodes to probe the brain and slowly and painfully piece together +which part of the brain influenced which behavior." +"But the basic tools of neuroscience did not provide a systematic way of +analyzing the brain. You could not simply requisition a stroke victim +with damage in the specific area you wanted to study. Since the brain is +a living, dynamic system, autopsies often did not uncover the most +interesting features, such as how the parts of the brain interact, let alone +how they produced such diverse thoughts as love, hate, jealousy, and +curiosity. + +TWIN REVOLUTIONS + +Four hundred years ago, the telescope was invented, and almost +overnight, this new, miraculous instrument peered into the heart of the +celestial bodies. It was one of the most revolutionary (and seditious) +instruments of all time. All of a sudden, with your own two eyes, you" +"could see the myths and dogma of the past evaporate like the morning +mist. Instead of being perfect examples of divine wisdom, the moon had +jagged craters, the sun had black spots, Jupiter had moons, Venus had +phases, and Saturn had rings. More was learned about the universe in +the fifteen years after the invention of the telescope than in all human +history put together. + +Like the invention of the telescope, the introduction of MRI machines +and a variety of advanced brain scans in the mid-1990s and 2000s has +transformed neuroscience. We have learned more about the brain in the +last fifteen years than in all prior human history, and the mind, once +considered out of reach, is finally assuming center stage." +"Nobel laureate Eric R. Kandel of the Max Planck Institute in Tubingen, +Germany, writes, “The most valuable insights into the human mind to +emerge during this period did not come from the disciplines traditionally +concerned with the mind—philosophy, psychology, or psycho-analysis. +Instead they came from a merger of these disciplines with the biology of +the brain....” + +Physicists have played a pivotal role in this endeavor, providing a +flood of new tools with acronyms like MRI, EEG, PET, CAT, TCM, TES, +and DBS that have dramatically changed the study of the brain. +Suddenly with these machines we could see thoughts moving within the +living, thinking brain. As neurologist V. S. Ramachandran of the +University of California, San Diego, says, “All of these questions that +philosophers have been studying for millennia, we scientists can begin to +explore by doing brain imaging and by studying patients and asking the +right questions.”" +"Looking back, some of my initial forays into the world of physics +intersected with the very technologies that are now opening up the mind +for science. In high school, for instance, I became aware of a new form +of matter, called antimatter, and decided to conduct a science project on +the topic. As it is one of the most exotic substances on Earth, I had to +appeal to the old Atomic Energy Commission just to obtain a tiny +quantity of sodium-22, a substance that naturally emits a positive +electron (anti-electron, or positron). With my small sample in hand, I +was able to build a cloud chamber and powerful magnetic field that +allowed me to photograph the trails of vapor left by antimatter particles. +I didn’t know it at the time, but sodium-22 would soon become +instrumental in a new technology, called PET (positron emission +tomography), which has since given us startling new insights into the +thinking brain." +"Yet another technology I experimented with in high school was +magnetic resonance. I attended a lecture by Felix Bloch of Stanford + + University, who shared the 1952 Nobel Prize for Physics with Edward + +Purcell for the discovery of nuclear magnetic resonance. Dr. Bloch +explained to us high school kids that if you had a powerful magnetic +field, the atoms would align vertically in that field like compass needles. +Then if you applied a radio pulse to these atoms at a precise resonant +frequency, you could make them flip over. When they eventually flipped +back, they would emit another pulse, like an echo, which would allow +you to determine the identity of these atoms. (Later, I used the principle +of magnetic resonance to build a 2.3-million-electron-volt particle +accelerator in my mom’s garage.)" +"Just a couple of years later, as a freshman at Harvard University, it +was an honor to have Dr. Purcell teach me electrodynamics. Around that +same time, I also had a summer job and got a chance to work with Dr. +Richard Ernst, who was trying to generalize the work of Bloch and +Purcell on magnetic resonance. He succeeded spectacularly and would +eventually win the Nobel Prize for Physics in 1991 for laying the +foundation for the modern MRI (magnetic resonance imaging) machine. +The MRI machine, in turn, has given us detailed photographs of the +living brain in even finer detail than PET scans. + +EMPOWERING THE MIND" +"EMPOWERING THE MIND + +Eventually I became a professor of theoretical physics, but my +fascination with the mind remained. It is thrilling to see that, just within +the last decade, advances in physics have made possible some of the +feats of mentalism that excited me when I was a child. Using MRI scans, +scientists can now read thoughts circulating in our brains. Scientists can +also insert a chip into the brain of a patient who is totally paralyzed and +connect it to a computer, so that through thought alone that patient can +surf the web, read and write e-mails, play video games, control their +wheelchair, operate household appliances, and manipulate mechanical +arms. In fact, such patients can do anything a normal person can do via +a computer." +"Scientists are now going even further, by connecting the brain directly +to an exoskeleton that these patients can wear around their paralyzed +limbs. Quadriplegics may one day lead near-normal lives. Such +exoskeletons may also give us superpowers enabling us to handle deadly + +emergencies. One day, our astronauts may even explore the planets by +mentally controlling mechanical surrogates from the comfort of their + + living rooms." +"living rooms. + +As in the movie The Matrix, we might one day be able to download +memories and skills using computers. In animal studies, scientists have +already been able to insert memories into the brain. Perhaps it’s only a +matter of time before we, too, can insert artificial memories into our +brains to learn new subjects, vacation in new places, and master new +hobbies. And if technical skills can be downloaded into the minds of +workers and scientists, this may even affect the world economy. We +might even be able to share these memories as well. One day, scientists +might construct an “Internet of the mind,” or a brain-net, where +thoughts and emotions are sent electronically around the world. Even +dreams will be videotaped and then “brain-mailed” across the Internet." +"Technology may also give us the power to enhance our intelligence. +Progress has been made in understanding the extraordinary powers of +“savants” whose mental, artistic, and mathematical abilities are truly +astonishing. Furthermore, the genes that separate us from the apes are +now being sequenced, giving us an unparalleled glimpse into the +evolutionary origins of the brain. Genes have already been isolated in +animals that can increase their memory and mental performance." +"The excitement and promise generated by these eye-opening advances +are so enormous that they have also caught the attention of the +politicians. In fact, brain science has suddenly become the source of a +transatlantic rivalry between the greatest economic powers on the +planet. In January 2013, both President Barack Obama and the European +Union announced what could eventually become multibillion-dollar +funding for two independent projects that would reverse engineer the +brain. Deciphering the intricate neural circuitry of the brain, once +considered hopelessly beyond the scope of modern science, is now the +focus of two crash projects that, like the Human Genome Project, will +change the scientific and medical landscape. Not only will this give us +unparalleled insight into the mind, it will also generate new industries, +spur economic activity, and open up new vistas for neuroscience." +"Once the neural pathways of the brain are finally decoded, one can +envision understanding the precise origins of mental illness, perhaps +leading to a cure for this ancient affliction. This decoding also makes it + +possible to create a copy of the brain, which raises philosophical and +ethical questions. Who are we, if our consciousness can be uploaded into +a computer? We can also toy with the concept of immortality. Our +bodies may eventually decay and die, but can our consciousness live +forever? + +And beyond that, perhaps one day in the distant future the mind will + + be freed of its bodily constraints and roam among the stars, as several +scientists have speculated. Centuries from now, one can imagine placing +our entire neural blueprint on laser beams, which will then be sent into +deep space, perhaps the most convenient way for our consciousness to +explore the stars." +"A brilliant new scientific landscape that will reshape human destiny is +now truly opening up. We are now entering a new golden age of +neuroscience. + +In making these predictions, I have had the invaluable assistance of +scientists who graciously allowed me to interview them, broadcast their +ideas on national radio, and even take a TV crew into their laboratories. +These are the scientists who are laying the foundation for the future of +the mind. For their ideas to be incorporated into this book, I made only +two requirements: (1) their predictions must rigorously obey the laws of +physics; and (2) prototypes must exist to show proof-of-principle for +these far-reaching ideas. + +TOUCHED BY MENTAL ILLN ESS" +"TOUCHED BY MENTAL ILLN ESS + +I once wrote a biography of Albert Einstein, called Einstein’s Cosmos, and +had to delve into the minute details of his private life. I had known that +Einstein’s youngest son was afflicted with schizophrenia, but did not +realize the enormous emotional toll that it had taken on the great +scientist’s life. Einstein was also touched by mental illness in another +way; one of his closest colleagues was the physicist Paul Ehrenfest, who +helped Einstein create the theory of general relativity. After suffering +bouts of depression, Ehrenfest tragically killed his own son, who had +Down’s syndrome, and then committed suicide. Over the years, I have +found that many of my colleagues and friends have struggled to manage +mental illness in their families." +"Mental illness has also deeply touched my own life. Several years ago, +my mother died after a long battle with Alzheimer’s disease. It was +heartbreaking to see her gradually lose her memories of her loved ones, +to gaze into her eyes and realize that she did not know who I was. I +could see the glimmer of humanity slowly being extinguished. She had +spent a lifetime struggling to raise a family, and instead of enjoying her +golden years, she was robbed of all the memories she held dear. + +As the baby boomers age, the sad experience that I and many others +have had will be repeated across the world. My wish is that rapid +advances in neuroscience will one day alleviate the suffering felt by +those afflicted with mental illness and dementia. + + WHAT IS DRIVING THIS REVOLUTION?" +"WHAT IS DRIVING THIS REVOLUTION? + +The data pouring in from brain scans are now being decoded, and the +progress is stunning. Several times a year, headlines herald a fresh +breakthrough. It took 350 years, since the invention of the telescope, to +enter the space age, but it has taken only fifteen years since the +introduction of the MRI and advanced brain scans to actively connect +the brain to the outside world. Why so quickly , and how much is there to +come?" +"Part of this rapid progress has occurred because physicists today have +a good understanding of electromagnetism, which governs the electrical +signals racing through our neurons. The mathematical equations of +James Clerk Maxwell, which are used to calculate the physics of +antennas, radar, radio receivers, and microwave towers, form the very +cornerstone of MRI technology. It took centuries to finally solve the +secret of electromagnetism, but neuroscience can enjoy the fruits of this +grand endeavor. In Book I, I will survey the history of the brain and +explain how a galaxy of new instruments has left the physics labs and +given us glorious color pictures of the mechanics of thought. Because +consciousness plays so central a role in any discussion of the mind, I also +give a physicist’s perspective, offering a definition of consciousness that +includes the animal kingdom as well. In fact, I provide a ranking of +consciousness, showing how it is possible to assign a number to various" +"consciousness, showing how it is possible to assign a number to various +types of consciousness." +"But to fully answer the question of how this technology will advance, +we also have to look at Moore’s law, which states that computer power +doubles every two years. I often surprise people with the simple fact that +your cell phone today has more computer power than all of NASA when +it put two men on the moon in 1969. Computers are now powerful +enough to record the electrical signals emanating from the brain and +partially decode them into a familiar digital language. This makes it +possible for the brain to directly interface with computers to control any +object around it. The fast-growing field is called BMI (brain-machine +interface), and the key technology is the computer. In Book II, I’ll +explore this new technology, which has made recording memories, mind +reading, videotaping our dreams, and telekinesis possible." +"In Book III, I’ll investigate alternate forms of consciousness, from +dreams, drugs, and mental illness to robots and even aliens from outer +space. Here we’ll also learn about the potential to control and +manipulate the brain to manage diseases such as depression, Parkinson’s, +Alzheimer’s, and many more. I will also elaborate on the Brain Research +Through Advancing Innovative Neurotechnologies (or BRAIN) project + + announced by President Obama, and the Human Brain Project of the +European Union, which will potentially allocate billions of dollars to +decode the pathways of the brain, all the way down to the neural level. +These two crash programs will undoubtedly open up entirely new +research areas, giving us new ways to treat mental illness and also +revealing the deepest secrets of consciousness." +"After we have given a definition of consciousness, we can use it to +explore nonhuman consciousness as well (i.e., the consciousness of +robots). How advanced can robots become? Can they have emotions? +Will they pose a threat? And we can also explore the consciousness of +aliens, who may have goals totally different from ours. + +In the Appendix, I will discuss perhaps the strangest idea in all of +science, the concept from quantum physics that consciousness may be +the fundamental basis for reality. + +There is no shortage of proposals for this exploding field. Only time +will tell which ones are mere pipe dreams created by the overheated +imagination of science-fiction writers and which ones represent solid +avenues for future scientific research. Progress in neuroscience has been +astronomical, and in many ways the key has been modern physics, + +which uses the full power of the electromagnetic and nuclear forces to +probe the great secrets hidden within our minds." +"I should stress that I am not a neuroscientist. I am a theoretical +physicist with an enduring interest in the mind. I hope that the vantage +point of a physicist can help further enrich our knowledge and give a +fresh new understanding of the most familiar and alien object in the +universe: our mind. + +But given the dizzying pace with which radically new perspectives are +being developed, it is important that we have a firm grasp on how the +brain is put together. + +So let us first discuss the origins of modern neuroscience, which some +historians believe began when an iron spike sailed through the brain of a +certain Phineas Gage. This seminal event set off a chain reaction that +helped open the brain to serious scientific investigation. Although it was +an unfortunate event for Mr. Gage, it paved the way for modern science. + +BOOK I THE MIND AND CONSCIOUSNESS + +My fundamental premise about the brain is that its workings—" +"BOOK I THE MIND AND CONSCIOUSNESS + +My fundamental premise about the brain is that its workings— + + what we sometimes call “mind”—are a consequence of its +anatomy and physiology, and nothing more. + +—CARL SAGAN + +1 UNLOCKING THE MIND + +In 1848, Phineas Gage was working as a railroad foreman in Vermont, +when dynamite accidentally went off, propelling a three-foot, seven-inch +spike straight into his face, through the front part of his brain, and out +the top of his skull, eventually landing eighty feet away. His fellow +workers, shocked to see part of their foreman’s brain blown off, +immediately called for a doctor. To the workers’ (and even the doctor’s) +amazement, Mr. Gage did not die on-site." +"He was semiconscious for weeks, but eventually made what seemed +like a full recovery. (A rare photograph of Gage surfaced in 2009, +showing a handsome, confident man, with an injury to his head and left +eye, holding the iron rod.) But after this incident, his coworkers began to +notice a sharp change in his personality. A normally cheerful, helpful +foreman, Gage became abusive, hostile, and selfish. Ladies were warned +to stay clear of him. Dr. John Harlow, the doctor who treated him, +observed that Gage was “capricious and vacillating, devising many plans +of future operations, which are no sooner arranged than they are +abandoned in turn for others appearing more feasible. A child in his +intellectual capacity and manifestations, yet with the animal passions of +a strong man.” Dr. Harlow noted that he was “radically changed” and +that his fellow workers said that “he was no longer Gage.” After Gage’s +death in 1860, Dr. Harlow preserved both his skull and the rod that had" +"death in 1860, Dr. Harlow preserved both his skull and the rod that had +smashed into it. Detailed X-ray scans of the skull have since confirmed +that the iron rod caused massive destruction in the area of the brain +behind the forehead known as the frontal lobe, in both the left and right +cerebral hemispheres." +"This incredible accident would not only change the life of Phineas +Gage, it would alter the course of science as well. Previously, the +dominant thinking was that the brain and the soul were two separate +entities, a philosophy called dualism. But it became increasingly clear +that damage to the frontal lobe of his brain had caused abrupt changes + +in Gage’s personality. This, in turn, created a paradigm shift in scientific +thinking: perhaps specific areas of the brain could be traced to certain +behaviors. + + broca’s brain" +"broca’s brain + +In 1861, just a year after Gage’s death, this view was further cemented +through the work of Pierre Paul Broca, a physician in Paris who +documented a patient who appeared normal except that he had a severe +speech deficit. The patient could understand and comprehend speech +perfectly, but he could utter only one sound, the word “tan.” After the +patient died, Dr. Broca confirmed during the autopsy that the patient +suffered from a lesion in his left temporal lobe, a region of the brain near +his left ear. Dr. Broca would later confirm twelve similar cases of +patients with damage to this specific area of the brain. Today patients +who have damage to the temporal lobe, usually in the left hemisphere, +are said to suffer from Broca’s aphasia. (In general, patients with this +disorder can understand speech but cannot say anything, or else they +drop many words when speaking.)" +"Soon afterward, in 1874, German physician Carl Wernicke described +patients who suffered from the opposite problem. They could articulate +clearly, but they could not understand written or spoken speech. Often +these patients could speak fluently with correct grammar and syntax, but +with nonsensical words and meaningless jargon. Sadly, these patients +often didn’t know they were spouting gibberish. Wernicke confirmed +after performing autopsies that these patients had suffered damage to a +slightly different area of the left temporal lobe. + +The works of Broca and Wernicke were landmark studies in +neuroscience, establishing a clear link between behavioral problems, +such as speech and language impairment, and damage to specific regions +of the brain." +"Another breakthrough took place amid the chaos of war. Throughout +history, there were many religious taboos prohibiting the dissection of +the human body, which severely restricted progress in medicine. In +warfare, however, with tens of thousands of bleeding soldiers dying on +the battlefield, it became an urgent mission for doctors to develop any + +medical treatment that worked. During the Prusso-Danish War in 1864, +German doctor Gustav Fritsch treated many soldiers with gaping wounds +to the brain and happened to notice that when he touched one +hemisphere of the brain, the opposite side of the body often twitched. +Later Fritsch systematically showed that, when he electrically stimulated +the brain, the left hemisphere controlled the right side of the body, and +vice versa. This was a stunning discovery, demonstrating that the brain +was basically electrical in nature and that a particular region of the +brain controlled a part on the other side of the body. (Curiously, the use" +"of electrical probes on the brain was first recorded a couple of thousand +years earlier by the Romans. In the year A.D. 43, records show that the +court doctor to the emperor Claudius used electrically charged torpedo +fish, which were applied to the head of a patient suffering from severe +headaches.) + +The realization that there were electrical pathways connecting the +brain to the body wasn’t systematically analyzed until the 1930s, when +Dr. Wilder Penfield began working with epilepsy patients, who often +suffered from debilitating convulsions and seizures that were potentially +life-threatening. For them, the last option was to have brain surgery, +which involved removing parts of the skull and exposing the brain. +(Since the brain has no pain sensors, a person can be conscious during +this entire procedure, so Dr. Penfield used only a local anesthetic during +the operation.)" +"Dr. Penfield noticed that when he stimulated certain parts of the +cortex with an electrode, different parts of the body would respond. He +suddenly realized that he could draw a rough one-to-one correspondence +between specific regions of the cortex and the human body. His +drawings were so accurate that they are still used today in almost +unaltered form. They had an immediate impact on both the scientific +community and the general public. In one diagram, you could see which +region of the brain roughly controlled which function, and how +important each function was. For example, because our hands and +mouth are so vital for survival, a considerable amount of brain power is +devoted to controlling them, while the sensors in our back hardly +register at all. + +Furthermore, Penfield found that by stimulating parts of the temporal +lobe, his patients suddenly relived long-forgotten memories in a crystal-" +"clear fashion. He was shocked when a patient, in the middle of brain +surgery, suddenly blurted out, “It was like ... standing in the doorway at +[my] high school.... I heard my mother talking on the phone, telling my +aunt to come over that night.” Penfield realized that he was tapping into +memories buried deep inside the brain. When he published his results in +1951, they created another transformation in our understanding of the +brain. + +Figure 1. This is the map of the motor cortex that was created by Dr. Wilder Penfield, showing which +region of the brain + +controls which part of the body, (illustration credit 1.1) + + A MAP OF THE BRAIN + +By the 1950s and ’60s, it was possible to create a crude map of the brain, +locating different regions and even identifying the functions of a few of +them." +"In Figure 2, we see the neocortex, which is the outer layer of the +brain, divided into four lobes. It is highly developed in humans. All the +lobes of the brain are devoted to processing signals from our senses, +except for one: the frontal lobe, located behind the forehead. The +prefrontal cortex, the foremost part of the frontal lobe, is where most +rational thought is processed. The information you are reading right now +is being processed in your prefrontal cortex. Damage to this area can +impair your ability to plan or contemplate the future, as in the case of +Phineas Gage. This is the region where information from our senses is +evaluated and a future course of action is carried out. + +FRONTAL +LOBE + +PARIETAL +LOBE + +OCCIPITAL + +LOBE + +TEMPORAL + +LOBE + + Figure 2. The four lobes of the neocortex of the brain are responsible for different, though related, +functions, (illustration + +credit 1.2)" +"credit 1.2) + +The parietal lobe is located at the top of our brains. The right +hemisphere controls sensory attention and body image; the left +hemisphere controls skilled movements and some aspects of language. +Damage to this area can cause many problems, such as difficulty in +locating parts of your own body. + +The occipital lobe is located at the very back of the brain and +processes visual information from the eyes. Damage to this area can +cause blindness and visual impairment. + +The temporal lobe controls language (on the left side only), as well as +the visual recognition of faces and certain emotional feelings. Damage to +this lobe can leave us speechless or without the ability to recognize +familiar faces. + +THE EVOLVING BRAIN" +"THE EVOLVING BRAIN + +When you look at other organs of the body, such as our muscles, bones, +and lungs, there seems to be an obvious rhyme and reason to them that +we can immediately see. But the structure of the brain might seem +slapped together in a rather chaotic fashion. In fact, trying to map the +brain has often been called “cartography for fools.”" +"To make sense of the seemingly random structure of the brain, in 1967 +Dr. Paul MacLean of the National Institute of Mental Health applied +Charles Darwin’s theory of evolution to the brain. He divided the brain +into three parts. (Since then, studies have shown that there are +refinements to this model, but we will use it as a rough organizing +principle to explain the overall structure of the brain.) First, he noticed +that the back and center part of our brains, containing the brain stem, +cerebellum, and basal ganglia, are almost identical to the brains of +reptiles. Known as the “reptilian brain,” these are the oldest structures of +the brain, governing basic animal functions such as balance, breathing, +digestion, heartbeat, and blood pressure. They also control behaviors +such as fighting, hunting, mating, and territoriality, which are necessary +for survival and reproduction. The reptilian brain can be traced back +about 500 million years. (See Figure 3.)" +"But as we evolved from reptiles to mammals, the brain also became +more complex, evolving outward and creating entirely new structures. + + Here we encounter the “mammalian brain,” or the limbic system, which +is located near the center of the brain, surrounding parts of the reptilian +brain. The limbic system is prominent among animals living in social +groups, such as the apes. It also contains structures that are involved in +emotions. Since the dynamics of social groups can be quite complex, the +limbic system is essential in sorting out potential enemies, allies, and +rivals. + +HUMAN + +BRAIN + +Hypothalamus + +MAMMALIAN +L BRAIN . + +REPTILIAN + +BRAIN + +Corpus callosum + +Cingulate gyrus + +Frontal lobe + +Hippocampus + +Forn + +Cerebellum + +Brain stem + +Pituitary + + gland" +"Frontal lobe + +Hippocampus + +Forn + +Cerebellum + +Brain stem + +Pituitary + + gland + +Figure 3. The evolutionary history of the brain, with the reptilian brain, the limbic system (the +mammalian brain), and the +neocortex (the human brain). Roughly speaking, one can argue that the path of our brain’s evolution +passed from the +reptilian brain to the mammalian brain to the human brain, (illustration credit 1.3) + +The different parts of the limbic system that control behaviors crucial +for social animals are: + +• The hippocampus. This is the gateway to memory, where short-term +memories are processed into long-term memories. Its name means +“seahorse,” which describes its strange shape. Damage here will +destroy the ability to make new long-term memories. You are left a +prisoner of the present. + +• The amygdala. This is the seat of emotions, especially fear, where +emotions are first registered and generated. Its name means +“almond.”" +"• The thalamus. This is like a relay station, gathering sensory signals +from the brain stem and then sending them out to the various +cortices. Its name means “inner chamber.” + +• The hypothalamus. This regulates body temperature, our circadian +rhythm, hunger, thirst, and aspects of reproduction and pleasure. It +lies below the thalamus—hence its name. + +Finally, we have the third and most recent region of the mammalian +brain, the cerebral cortex, which is the outer layer of the brain. The +latest evolutionary structure within the cerebral cortex is the neocortex +(meaning “new bark”), which governs higher cognitive behavior. It is +most highly developed in humans: it makes up 80 percent of our brain’s +mass, yet is only as thick as a napkin. In rats the neocortex is smooth, +but it is highly convoluted in humans, which allows a large amount of +surface area to be crammed into the human skull." +"In some sense, the human brain is like a museum containing remnants +of all the previous stages in our evolution over millions of years, +exploding outward and forward in size and function. (This is also +roughly the path taken when an infant is born. The infant brain expands +outward and toward the front, perhaps mimicking the stages of our +evolution.) + +Although the neocortex seems unassuming, looks are deceiving. Under +a microscope you can appreciate the intricate architecture of the brain. +The gray matter of the brain consists of billions of tiny brain cells called +neurons. Like a gigantic telephone network, they receive messages from +other neurons via dendrites, which are like tendrils sprouting from one +end of the neuron. At the other end of the neuron, there is a long fiber +called the axon. Eventually the axon connects to as many as ten" +"thousand other neurons via their dendrites. At the juncture between the +two, there is a tiny gap called the synapse. These synapses act like gates, +regulating the flow of information within the brain. Special chemicals +called neurotransmitters can enter the synapse and alter the flow of +signals. Because neurotransmitters like dopamine, serotonin, and +noradrenaline help control the stream of information moving across the +myriad pathways of the brain, they exert a powerful effect on our +moods, emotions, thoughts, and state of mind. (See Figure 4.) + +This description of the brain roughly represented the state of +knowledge through the 1980s. In the 1990s, however, with the +introduction of new technologies from the field of physics, the +mechanics of thought began to be revealed in exquisite detail, +unleashing the current explosion of scientific discovery. One of the +workhorses of this revolution has been the MRI machine." +"Figure 4. Diagram of a neuron. Electrical signals travel along the axon of the neuron until they hit the +synapse. +Neurotransmitters can regulate the flow of electrical signals past the synapse, (illustration credit 1.4) + +THE MRI: WINDOW INTO THE BRAIN + +To understand the reason why this radical new technology has helped +decode the thinking brain, we have to turn our attention to some basic +principles of physics. + +Radio waves, a type of electromagnetic radiation, can pass right + + through tissue without doing damage. MRI machines take advantage of +this fact, allowing electromagnetic waves to freely penetrate the skull. In +the process, this technology has given us glorious photographs of +something once thought to be impossible to capture: the inner workings + +of the brain as it experiences sensations and emotions. Watching the +dance of lights flickering in a MRI machine, one can trace out the +thoughts moving within the brain. It’s like being able to see the inside of +a clock as it ticks." +"The first thing you notice about an MRI machine is the huge, +cylindrical magnetic coils, which can produce a magnetic field twenty to +sixty thousand times greater than the strength of Earth’s. The giant +magnet is one of the principal reasons why an MRI machine can weigh a +ton, fill up an entire room, and cost several million dollars. (MRI +machines are safer than X-ray machines because they don’t create +harmful ions. CT scans, which can also create 3-D pictures, flood the +body with many times the dosage from an ordinary X-ray, and hence +have to be carefully regulated. By contrast, MRI machines are safe when +used properly. One problem, however, is the carelessness of workers. +The magnetic field is powerful enough to send tools hurling through the +air at high velocity when turned on at the wrong time. People have been +injured and even killed in this way.)" +"MRI machines work as follows: Patients lie flat and are inserted into a +cylinder containing two large coils, which create the magnetic field. +When the magnetic field is turned on, the nuclei of the atoms inside your +body act very much like a compass needle: they align horizontally along +the direction of the field. Then a small pulse of radio energy is +generated, which causes some of the nuclei in our body to flip upside +down. When the nuclei later revert back to their normal position, they +emit a secondary pulse of radio energy, which is then analyzed by the +MRI machine. By analyzing these tiny “echoes,” one can then reconstruct +the location and nature of these atoms. Like a bat, which uses echoes to +determine the position of objects in its path, the echoes created by the +MRI machine allow scientists to re-create a remarkable image of the +inside of the brain. Computers then reconstruct the position of the +atoms, giving us beautiful diagrams in three dimensions." +"When MRIs were originally introduced, they were able to show the +static structure of the brain and its various regions. However, in the mid- +1990s, a new type of MRI was invented, called “functional” MRI, or +fMRI, which detected the presence of oxygen in the blood in the brain. +(For different types of MRI machines, scientists sometimes put a +lowercase letter in front of “MRI,” but we will use the abbreviation MRI + + to denote all the various types of MRI machines.) MRI scans cannot +directly detect the flow of electricity in the neurons, but since oxygen is +necessary to provide the energy for the neurons, oxygenated blood can +indirectly trace the flow of electrical energy in the neurons and show +how various regions of the brain interact with one another." +"Already these MRI scans have definitively disproven the idea that +thinking is concentrated in a single center. Instead, one can see electrical +energy circulating across different parts of the brain as it thinks. By +tracing the path taken by our thoughts, MRI scans have shed new light +into the nature of Alzheimer’s, Parkinson’s, schizophrenia, and a host of +other mental diseases. + +The great advantage of MRI machines is their exquisite ability to +locate minute parts of the brain, down to a fraction of a millimeter in +size. An MRI scan will create not just dots on a two-dimensional screen, +called pixels, but dots in three-dimensional space, called “voxels,” +yielding a bright collection of tens of thousands of colored dots in 3-D, in +the shape of a brain." +"Since different chemical elements respond to different frequencies of +radio, you can change the frequency of the radio pulse and therefore +identify different elements of the body. As noted, fMRI machines zero in +on the oxygen atom contained within blood in order to measure blood +flow, but MRI machines can also be tuned to identify other atoms. In just +the last decade, a new form of MRI was introduced called “diffusion +tensor imaging” MRI, which detects the flow of water in the brain. Since +water follows the neural pathways of the brain, DTI yields beautiful +pictures that resemble networks of vines growing in a garden. Scientists +can now instantly determine how certain parts of the brain are hooked +up with other parts." +"There are a couple of drawbacks to MRI technology, however. +Although they are unparalleled in spatial resolution, locating voxels +down to the size of a pinpoint in three dimensions, MRIs are not that +good in temporal resolution. It takes almost a full second to follow the +path of blood in the brain, which may not sound like a lot, but +remember that electrical signals travel almost instantly throughout the +brain, and hence MRI scans can miss some of the intricate details of +thought patterns. + +Another snag is the cost, which runs in the millions of dollars, so + +doctors often have to share the machines. But like most technology, +developments should bring down the cost over time." +"In the meantime, exorbitant costs haven’t stalled the hunt for +commercial applications. One idea is to use MRI scans as lie detectors, +which, according to some studies, can identify lies with 95 percent +accuracy or higher. The level of accuracy is still controversial, but the +basic idea is that when a person tells a lie, he simultaneously has to +know the truth, concoct the lie, and rapidly analyze the consistency of +this lie with previously known facts. Today some companies are claiming +that MRI technology shows that the prefrontal and parietal lobes light up +when someone tells a lie. More specifically, the “orbitofrontal cortex” +(which can serve, among other functions, as the brain’s “fact-checker” to +warn us when something is wrong) becomes active. This area is located +right behind the orbits of our eyes, and hence the name. The theory goes +that the orbitofrontal cortex understands the difference between the +truth and a lie and kicks into overdrive as a result. (Other areas of the" +"truth and a lie and kicks into overdrive as a result. (Other areas of the +brain also light up when someone tells a lie, such as the superiormedial +and inferolateral prefrontal cortices, which are involved in cognition.)" +"Already there are several commercial firms offering MRI machines as +lie detectors, and cases involving these machines are entering the court +system. But it’s important to note that these MRI scans indicate increased +brain activity only in certain areas. While DNA results can sometimes +have an accuracy of one part in 10 billion or better, MRI scans cannot, +because it takes many areas of the brain to concoct a lie, and these same +areas of the brain are responsible for processing other kinds of thoughts +as well. + +EEG SCANS + +Another useful tool to probe deep inside the brain is the EEG, the +electroencephalogram. The EEG was introduced all the way back in +1924, but only recently has it been possible to employ computers to +make sense out of all the data pouring in from each electrode. + +To use the EEG machine, the patient usually puts on a futuristic- +looking helmet with scores of electrodes on the surface. (More advanced +versions place a hairnet over the head containing a series of tiny" +"electrodes.) These electrodes detect the tiny electrical signals that are +circulating in the brain. + +(illustration credit 1.5) + + Figure 5. At the top, we see an image taken by a functional MRI machine, showing regions of high +mental activity. In the + +bottom image, we see the flowerlike pattern created by a diffusion MRI machine, which can follow the +neural pathways + +and connections of the brain, (illustration credit 1.5a)" +"An EEG scan differs from an MRI scan in several crucial ways. The +MRI scan, as we have seen, shoots radio pulses into the brain and then +analyzes the “echoes” that come back. This means you can vary the +radio pulse to select different atoms for analysis, making it quite +versatile. The EEG machine, however, is strictly passive; that is, it +analyzes the tiny electromagnetic signals the brain naturally emits. The +EEG excels at recording the broad electromagnetic signals that surge +across the entire brain, which allows scientists to measure the overall +activity of the brain as it sleeps, concentrates, relaxes, dreams, etc. +Different states of consciousness vibrate at different frequencies. For +example, deep sleep corresponds to delta waves, which vibrate at .1 to 4 +cycles per second. Active mental states, such as problem solving, +correspond to beta waves, vibrating from 12 to 30 cycles per second. +These vibrations allow various parts of the brain to share information" +"These vibrations allow various parts of the brain to share information +and communicate with one another, even if they are located on opposite +sides of the brain. And while MRI scans measuring blood flow can be +taken only several times a second, EEG scans measure electrical activity +instantly." +"The greatest advantage of the EEG scan, though, is its convenience +and cost. Even high school students have done experiments in their +living rooms with EEG sensors placed over their heads. + +However, the main drawback to the EEG, which has held up its +development for decades, is its very poor spatial resolution. The EEG +picks up electrical signals that have already been diffused after passing +through the skull, making it difficult to detect abnormal activity when it +originates deep in the brain. Looking at the output of the muddled EEG +signals, it is almost impossible to say for sure which part of the brain +created it. Furthermore, slight motions, like moving a finger, can distort +the signal, sometimes rendering it useless. + +PET SCANS + + Yet another useful tool from the world of physics is the positron +emission topography (PET) scan, which calculates the flow of energy in" +"the brain by locating the presence of glucose, the sugar molecule that +fuels cells. Like the cloud chamber I made as a high school student, PET +scans make use of the subatomic particles emitted from sodium-22 +within the glucose. To start the PET scan, a special solution containing +slightly radioactive sugar is injected into the patient. The sodium atoms +inside the sugar molecules have been replaced by radioactive sodium-22 +atoms. Every time a sodium atom decays, it emits a positive electron, or +positron, which is easily detected by sensors. By following the path of +the radioactive sodium atoms in sugar, one can then trace out the energy +flow within the living brain. + +The PET scan shares many of the same advantages of MRI scans but +does not have the fine spatial resolution of an MRI photo. However, +instead of measuring blood flow, which is only an indirect indicator of +energy consumption in the body, PET scans measure energy +consumption, so it is more closely related to neural activity." +"There is another drawback to PET scans, however. Unlike MRI and +EEG scans, PET scans are slightly radioactive, so patients cannot +continually take them. In general, a person is not allowed to have a PET +scan more than once a year because of the risk from radiation. + +MAGNETISM IN THE BRAIN + +Within the last decade, many new high-tech devices have entered the +tool kit of neuroscientists, including the transcranial electromagnetic +scanner (TES), magnetoencephalography (MEG), near-infrared +spectroscopy (NIRS), and optogenetics, among others." +"In particular, magnetism has been used to systematically shut down +specific parts of the brain without cutting it open. The basic physics +behind these new tools is that a rapidly changing electric field can create +a magnetic field, and vice versa. MEGs passively measure the magnetic +fields produced by the changing electric fields of the brain. These +magnetic fields are weak and extremely tiny, only a billionth of Earth’s +magnetic field. Like the EEG, the MEG is extremely good at time +resolution, down to a thousandth of a second. Its spatial resolution, +however, is only a cubic centimeter. + +Unlike the passive measurement of the MEG, the TES generates a large + + pulse of electricity, which in turn creates a burst of magnetic energy. +The TES is placed next to the brain, so the magnetic pulse penetrates the +skull and creates yet another electric pulse inside the brain. This +secondary electrical pulse, in turn, is sufficient to turn off or dampen the +activity of selected areas of the brain." +"Historically, scientists had to rely on strokes or tumors to silence +certain parts of the brain and hence determine what they do. But with +the TES, one can harmlessly turn off or dampen parts of the brain at will. +By shooting magnetic energy at a particular spot in the brain, one can +determine its function by simply watching how a person’s behavior has +changed. (For example, by shooting magnetic pulses into the left +temporal lobe, one can see that this adversely affects our ability to talk.)" +"One potential drawback of the TES is that these magnetic fields do not +penetrate very far into the interior of the brain (because magnetic fields +decrease much faster than the usual inverse square law for electricity). +TES is quite useful in turning off parts of the brain near the skull, but the +magnetic field cannot reach important centers located deep in the brain, +such as the limbic system. But future generations of TES devices may +overcome this technical problem by increasing the intensity and +precision of the magnetic field. + +Wire coil + +Pulsed magnetic field + +Stimulated +brain region + +Positioning + +frame + +Figure 6. We see the transcranial electromagnetic scanner and the magnetoencephalograph, which uses +magnetism rather +than radio waves to penetrate the skull and determine the nature of thoughts within the brain. +Magnetism can +temporarily silence parts of the brain, allowing scientists to safely determine how these regions perform +without relying" +"on stroke victims, (illustration credit 1.6) + +DEEP BRAIN STIMULATION + +Yet another tool that has proven vital to neurologists is deep brain +stimulation (DBS). The probes originally used by Dr. Penfield were +relatively crude. Today these electrodes can be hairlike and reach +specific areas of the brain deep within its interior. Not only has DBS +allowed scientists to locate the function of various parts of the brain, it +can also be used to treat mental disorders. DBS has already proven its + +worth with Parkinson’s disease, in which certain regions of the brain are +overactive and often create uncontrollable shaking of the hands. + +More recently, these electrodes have targeted a new area of the brain +(called Brodmann’s area number 25) that is often overactive in +depressed patients who do not respond to psychotherapy or drugs. Deep +brain stimulation has given almost miraculous relief after decades of +torment and agony for these long-suffering patients." +"Every year, new uses for deep brain stimulation are being found. In +fact, nearly all the major disorders of the brain are being reexamined in +light of this and other new brain-scanning technologies. This promises to +be an exciting new area for diagnosing and even treating illnesses. + +OPTOGENETICS—LIGHTING UP THE BRAIN + +But perhaps the newest and most exciting instrument in the neurologist’s +tool kit is optogenetics, which was once considered science fiction. Like +a magic wand, it allows you to activate certain pathways controlling +behavior by shining a light beam on the brain. + +Incredibly, a light-sensitive gene that causes a cell to fire can be +inserted, with surgical precision, directly into a neuron. Then, by turning +on a light beam, the neuron is activated. More importantly, this allows +scientists to excite these pathways, so that you can turn on and off +certain behaviors by flicking a switch." +"Although this technology is only a decade old, optogenetics has +already proven successful in controlling certain animal behaviors. By + + turning on a light switch, it is possible to make fruit flies suddenly fly +off, worms stop wiggling, and mice run around madly in circles. Monkey +trials are now beginning, and even human trials are in discussion. There +is great hope that this technology will have a direct application in +treating disorders like Parkinson’s and depression. + +THE TRANSPARENT BRAIN + +Like optogenetics, another spectacular new development is making the +brain fully transparent so that its neural pathways are exposed to the +naked eye. In 2013, scientists at Stanford University announced that + +they had successfully made the entire brain of a mouse transparent, as +well as parts of a human brain. The announcement was so stunning that +it made the front page of the New York Times, with the headline “Brain +as Clear as Jell-0 for Scientists to Explore.”" +"At the cellular level, cells seen individually are transparent, with all +their microscopic components fully exposed. However, once billions of +cells come together to form organs like the brain, the addition of lipids +(fats, oils, waxes, and chemicals not soluble in water) helps make the +organ opaque. The key to the new technique is to remove the lipids +while keeping the neurons intact. The scientists at Stanford did this by +placing the brain in hydrogel (a gel-like substance mainly made of +water), which binds to all the brain’s molecules except the lipids. By +placing the brain in a soapy solution with an electric field, the solution +can be flushed out of the brain, carrying along the lipids, leaving the +brain transparent. The addition of dyes can then make the neural +pathways visible. This will help to identify and map the many neural +pathways of the brain." +"Making tissue transparent is not new, but getting precisely the right +conditions necessary to make the entire brain transparent took a lot of +ingenuity. “I burned and melted more than a hundred brains,” confessed +Dr. Kwanghun Chung, one of the lead scientists in the study. The new +technique, called Clarity, can also be applied to other organs (and even +organs preserved years ago in chemicals like formalin). He has already +created transparent livers, lungs, and hearts. This new technique has +startling applications across all of medicine. In particular, it will +accelerate locating the neural pathways of the brain, which is the focus +of intense research and funding. + +FOUR FUNDAMENTAL FORCES" +"FOUR FUNDAMENTAL FORCES + + The success of this first generation of brain scans has been nothing less +than spectacular. Before their introduction, only about thirty or so +regions of the brain were known with any certainty. Now the MRI +machine alone can identify two to three hundred regions of the brain, +opening up entirely new frontiers for brain science. With so many new +scanning technologies being introduced from physics just within the last + +fifteen years, one might wonder: Are there more? The answer is yes, but +they will be variations and refinements of the previous ones, not +radically new technologies. This is because there are only four +fundamental forces—gravitational, electromagnetic, weak nuclear, and +strong nuclear—that rule the universe. (Physicists have tried to find +evidence for a fifth force, but so far all such attempts have failed.)" +"The electromagnetic force, which lights up our cities and represents +the energy of electricity and magnetism, is the source of almost all the +new scanning technologies (with the exception of the PET scan, which is +governed by the weak nuclear force). Because physicists have had over +150 years of experience working with the electromagnetic force, there is +no mystery in creating new electric and magnetic fields, so any new +brain-scanning technology will most likely be a novel modification of +existing technologies, rather than being something entirely new. As with +most technology, the size and cost of these machines will drop, vastly +increasing the widespread use of these sophisticated instruments. +Already physicists are doing the basic calculations necessary to make an +MRI machine fit into a cell phone. At the same time, the fundamental +challenge facing these brain scans is resolution, both spatial and +temporal. The spatial resolution of MRI scans will increase as the" +"temporal. The spatial resolution of MRI scans will increase as the +magnetic field becomes more uniform and as the electronics become +more sensitive. At present, MRI scans can see only dots or voxels within +a fraction of a millimeter. But each dot may contain hundreds of +thousands of neurons. New scanning technology should reduce this even +further. The holy grail of this approach would be to create an MRI-like +machine that could identify individual neurons and their connections." +"The temporal resolution of MRI machines is also limited because they +analyze the flow of oxygenated blood in the brain. The machine itself +has very good temporal resolution, but tracing the flow of blood slows it +down. In the future, other MRI machines will be able to locate different +substances that are more directly connected to the firing of neurons, +thereby allowing real-time analysis of mental processes. No matter how +spectacular the successes of the past fifteen years, then, they were just a +taste of the future. + +NEW MODELS OF THE BRAIN + + Historically, with each new scientific discovery, a new model of the +brain has emerged. One of the earliest models of the brain was the +“homunculus,” a little man who lived inside the brain and made all the +decisions. This picture was not very helpful, since it did not explain what +was happening in the brain of the homunculus. Perhaps there was a +homunculus hiding inside the homunculus." +"With the arrival of simple mechanical devices, another model of the +brain was proposed: that of a machine, such as a clock, with mechanical +wheels and gears. This analogy was useful for scientists and inventors +like Leonardo da Vinci, who actually designed a mechanical man." +"During the late 1800s, when steam power was carving out new +empires, another analogy emerged, that of a steam engine, with flows of +energy competing with one another. This hydraulic model, historians +have conjectured, affected Sigmund Freud’s picture of the brain, in +which there was a continual struggle between three forces: the ego +(representing the self and rational thought), the id (representing +repressed desires), and the superego (representing our conscience). In +this model, if too much pressure built up because of a conflict among +these three, there could be a regression or general breakdown of the +entire system. This model was ingenious, but as even Freud himself +admitted, it required detailed studies of the brain at the neuronal level, +which would take another century." +"Early in the last century, with the rise of the telephone, another +analogy surfaced—that of a giant switchboard. The brain was a mesh of +telephone lines connected into a vast network. Consciousness was a long +row of telephone operators sitting in front of a large panel of switches, +constantly plugging and unplugging wires. Unfortunately, this model +said nothing about how these messages were wired together to form the +brain. + +With the rise of the transistor, yet another model became fashionable: +the computer. The old-fashioned switching stations were replaced by +microchips containing hundreds of millions of transistors. Perhaps the +“mind” was just a software program running on “wetware” (i.e., brain +tissue rather than transistors). This model is an enduring one, even +today, but it has limitations. The transistor model cannot explain how +the brain performs computations that would require a computer the size +of New York City. Plus the brain has no programming, no Windows" +"operating system or Pentium chip. (Also, a PC with a Pentium chip is +extremely fast, but it has a bottleneck. All calculations must pass + + through this single processor. The brain is the opposite. The firing of +each neuron is relatively slow, but it more than makes up for this by +having 100 billion neurons processing data simultaneously. Therefore a +slow parallel processor can trump a very fast single processor.) + +The most recent analogy is that of the Internet, which lashes together +billions of computers. Consciousness, in this picture, is an “emergent” +phenomenon, miraculously arising out of the collective action of billions +of neurons. (The problem with this picture is that it says absolutely +nothing about how this miracle occurs. It brushes all the complexity of +the brain under the rug of chaos theory.)" +"No doubt each of these analogies has kernels of truth, but none of +them truly captures the complexity of the brain. However, one analogy +for the brain that I have found useful (albeit still imperfect) is that of a +large corporation. In this analogy, there is a huge bureaucracy and lines +of authority, with vast flows of information channeled between different +offices. But the important information eventually winds up at the +command center with the CEO. There the final decisions are made. + +If this analogy of the brain to a large corporation is valid, then it +should be able to explain certain peculiar features of the brain:" +"• Most information is “subconscious” —that is, the CEO is blissfully +unaware of the vast, complex information that is constantly flowing +inside the bureaucracy. In fact, only a tiny amount of information +finally reaches the desk of the CEO, who can be compared to the +prefrontal cortex. The CEO just has to know information important +enough to get his attention; otherwise, he would be paralyzed by an +avalanche of extraneous information. + +This arrangement is probably a by-product of evolution, since our +ancestors would have been overwhelmed with superfluous, +subconscious information flooding their brains when facing an +emergency. We are all mercifully unaware of the trillions of +calculations being processed in our brains. Upon encountering a +tiger in the forest, one does not have to be bothered with the status +of our stomach, toes, hair, etc. All one has to know is how to run. + +• “Emotions” are rapid decisions made independently at a lower" +"• “Emotions” are rapid decisions made independently at a lower + +level. Since rational thought takes many seconds, this means that it +is often impossible to make a reasoned response to an emergency; +hence lower-level brain regions must rapidly assess the situation and +make a decision, an emotion, without permission from the top. + +So emotions (fear, anger, horror, etc.) are instantaneous red flags + + made at a lower level, generated by evolution, to warn the +command center of possibly dangerous or serious situations. We +have little conscious control over emotions. For example, no matter +how much we practice giving a speech to a large audience, we still +feel nervous. + +Rita Carter, author of Mapping the Mind, writes, “Emotions are not +feelings at all but a set of body-rooted survival mechanisms that +have evolved to turn us away from danger and propel us forward to +things that may be of benefit.” + +• There is a constant clamoring for the attention of the CEO." +"• There is a constant clamoring for the attention of the CEO. + +There is no single homunculus, CPU, or Pentium chip making +decisions; instead, the various subcenters within the command +center are in constant competition with one another, vying for the +attention of the CEO. So there is no smooth, steady continuity of +thought, but the cacophony of different feedback loops competing +with one another. The concept of “I,” as a single, unified whole +making all decisions continuously, is an illusion created by our own +subconscious minds. + +Mentally we feel that our mind is a single entity, continuously and +smoothly processing information, totally in charge of our decisions. +But the picture emerging from brain scans is quite different from the +perception we have of our own mind. + +MIT professor Marvin Minsky, one of the founding fathers of +artificial intelligence, told me that the mind is more like a “society +of minds,” with different submodules, each trying to compete with +the others." +"When I interviewed Steven Pinker, a psychologist at Harvard +University, I asked him how consciousness emerges out of this mess. +He said that consciousness was like a storm raging in our brain. He +elaborated on this when he wrote that “the intuitive feeling we have +that there’s an executive T that sits in a control room of our brain, + +scanning the screens of the senses and pushing the buttons of our +muscles, is an illusion. Consciousness turns out to consist of a +maelstrom of events distributed across the brain. These events +compete for attention, and as one process outshouts the others, the +brain rationalizes the outcome after the fact and concocts the +impression that a single self was in charge all along.” + +• Final decisions are made by the CEO in the command center." +"• Final decisions are made by the CEO in the command center. + + Almost all the bureaucracy is devoted to accumulating and +assembling information for the CEO, who meets only with the +directors of each division. The CEO tries to mediate all the +conflicting information pouring into the command center. The buck +stops here. The CEO, located in the prefrontal cortex, has to make +the final decision. While most decisions are made by instinct in +animals, humans make higher-level decisions after sifting through +different bodies of information from our senses. + +• Information flows are hierarchical. Because of the vast amount of +information that must flow upward toward the CEO’s office, or +downward to the support staff, information must be arranged in +complex arrays of nested networks, with many branches. Think of a +pine tree, with the command center on top and a pyramid of +branches flowing downward, branching out into many subcenters." +"There are, of course, differences between a bureaucracy and the +structure of thought. The first rule of any bureaucracy is that “it +expands to fill the space allotted to it.” But wasting energy is a +luxury the brain cannot afford. The brain consumes only about +twenty watts of power (the power of a dim lightbulb), but that is +probably the maximum energy it can consume before the body +becomes dysfunctional. If it generates more heat, it will cause tissue +damage. Therefore the brain is constantly using shortcuts to +conserve energy. We will see throughout this book the clever and +ingenious devices that evolution has crafted, without our +knowledge, to cut corners. + +IS “REALITY” REALLY REAL? + +Everyone knows the expression “seeing is believing.” Yet much of what" +"IS “REALITY” REALLY REAL? + +Everyone knows the expression “seeing is believing.” Yet much of what + +we see is actually an illusion. For example, when we see a typical +landscape, it seems like a smooth, movielike panorama. In reality, there +is a gaping hole in our field of vision, corresponding to the location of +the optic nerve in the retina. We should see this large ugly black spot +wherever we look. But our brains fill in that hole by papering it over, by +averaging it out. This means that part of our vision is actually fake, +generated by our subconscious minds to deceive us. + +Also, we see only the center of our field of vision, called the fovea, +with clarity. The peripheral part is blurry, in order to save energy. But +the fovea is very small. To capture as much information as possible with +the tiny fovea, the eye darts around constantly. This rapid, jiggling +motion of our eyes is called saccades. All this is done subconsciously," +"giving us the false impression that our field of vision is clear and +focused. + +When I was a child and first saw a diagram showing the +electromagnetic spectrum in its true glory, I was shocked. I had been +totally unaware that huge parts of the EM spectrum (e.g., infrared light, +UV light, X-rays, gamma rays) were totally invisible to us. I began to +realize that what I saw with my eyes was only a tiny, crude +approximation of reality. (There is an old saying: “If appearance and +essence were the same thing, there would be no need for science.”) We +have sensors in the retina that can detect only red, green, and blue. This +means that we’ve never actually seen yellow, brown, orange, and a host +of other colors. These colors do exist, but our brain can approximate +each of them only by mixing different amounts of red, green, and blue. +(You can see this if you look at an old color-TV screen very carefully. +You see only a collection of red, green, and blue dots. Color TV is +actually an illusion.)" +"Our eyes also fool us into thinking we can see depth. The retinas of +our eyes are two-dimensional, but because we have two eyes separated +by a few inches, the left and right brain merge these two images, giving +us the false sense of a third dimension. For more distant objects, we can +judge how far an object is by observing how they move when we move +our head. This is called parallax. + +(This parallax explains the fact that children sometimes complain that +“the moon is following me.” Because the brain has difficulty +comprehending the parallax of an object as distant as the moon, it + +appears as if the moon is always a fixed distance “behind” them, but it’s +just an illusion caused by the brain taking a shortcut.) + +THE SPLIT-BRAIN PARADOX" +"THE SPLIT-BRAIN PARADOX + +One way in which this picture, based on the corporate hierarchy of a +company, deviates from the actual structure of the brain can be seen in +the curious case of split-brain patients. One unusual feature of the brain +is that it has two nearly identical halves, or hemispheres, the left and +right. Scientists have long wondered why the brain has this unnecessary +redundancy, since the brain can operate even if one entire hemisphere is +completely removed. No normal corporate hierarchy has this strange +feature. Furthermore, if each hemisphere has consciousness, does this +mean that we have two separate centers of consciousness inside one +skull?" +"Dr. Roger W. Sperry of the California Institute of Technology won the +Nobel Prize in 1981 for showing that the two hemispheres of the brain +are not exact carbon copies of each other, but actually perform different +duties. This result created a sensation in neurology (and also spawned a +cottage industry of dubious self-help books that claim to apply the left- +brain, right-brain dichotomy to your life). + +Dr. Sperry was treating epileptics, who sometimes suffer from grand +mal seizures often caused by feedback loops between the two +hemispheres that go out of control. Like a microphone screeching in our +ears because of a feedback loop, these seizures can become life- +threatening. Dr. Sperry began by severing the corpus callosum, which +connects the two hemispheres of the brain, so that they no longer +communicated and shared information between the left and right side of +the body. This usually stopped the feedback loop and the seizures." +"At first, these split-brain patients seemed perfectly normal. They were +alert and could carry on a natural conversation as if nothing had +happened. But a careful analysis of these individuals showed that +something was very different about them. + +Normally the hemispheres complement each other as thoughts move +back and forth between the two. The left brain is more analytical and +logical. It is where verbal skills are found, while the right brain is more + +holistic and artistic. But the left brain is the dominant one and makes the +final decisions. Commands pass from the left brain to the right brain via +the corpus callosum. But if that connection is cut, it means that the right +brain is now free from the dictatorship of the left brain. Perhaps the +right brain can have a will of its own, contradicting the wishes of the +dominant left brain." +"In short, there could be two wills acting within one skull, sometimes +struggling for control of the body. This creates the bizarre situation +where the left hand (controlled by the right brain) starts to behave +independently of your wishes, as if it were an alien appendage. + +There is one documented case in which a man was about to hug his +wife with one hand, only to find that the other hand had an entirely +different agenda. It delivered a right hook to her face. Another woman +reported that she would pick out a dress with one hand, only to see her +other hand grab an entirely different outfit. Meanwhile, one man had +difficulty sleeping at night thinking that his other rebellious hand might +strangle him. + +At times, split-brain people think they are living in a cartoon, where +one hand struggles to control the other. Physicians sometimes call this + + the Dr. Strangelove syndrome, because of a scene in the movie in which +one hand has to fight against the other hand." +"Dr. Sperry, after detailed studies of split-brain patients, finally +concluded that there could be two distinct minds operating in a single +brain. He wrote that each hemisphere is “indeed a conscious system in +its own right, perceiving, thinking, remembering, reasoning, willing, and +emoting, all at a characteristically human level, and ... both the left and +right hemisphere may be conscious simultaneously in different, even in +mutually conflicting, mental experiences that run along in parallel.”" +"When I interviewed Dr. Michael Gazzaniga of the University of +California, Santa Barbara, an authority on split-brain patients, I asked +him how experiments can be done to test this theory. There are a variety +of ways to communicate separately to each hemisphere without the +knowledge of the other hemisphere. One can, for example, have the +subject wear special glasses on which questions can be shown to each +eye separately, so that directing questions to each hemisphere is easy. +The hard part is trying to get an answer from each hemisphere. Since the +right brain cannot speak (the speech centers are located only in the left + +brain), it is difficult to get answers from the right brain. Dr. Gazzaniga +told me that to find out what the right brain was thinking, he created an +experiment in which the (mute) right brain could “talk” by using +Scrabble letters." +"He began by asking the patient’s left brain what he would do after +graduation. The patient replied that he wanted to become a draftsman. +But things got interesting when the (mute) right brain was asked the +same question. The right brain spelled out the words: “automobile +racer.” Unknown to the dominant left brain, the right brain secretly had +a completely different agenda for the future. The right brain literally had +a mind of its own. + +Rita Carter writes, “The possible implications of this are mind- +boggling. It suggests that we might all be carrying around in our skulls a +mute prisoner with a personality, ambition, and self-awareness quite +different from the day-to-day entity we believe ourselves to be.”" +"Perhaps there is truth to the oft-heard statement that “inside him, +there is someone yearning to be free.” This means that the two +hemispheres may even have different beliefs. For example, the +neurologist V. S. Ramanchandran describes one split-brain patient who, +when asked if he was a believer or not, said he was an atheist, but his +right brain declared he was a believer. Apparently, it is possible to have +two opposing religious beliefs residing in the same brain. Ramachandran +continues: “If that person dies, what happens? Does one hemisphere go + + to heaven and the other go to hell? I don’t know the answer to that.” + +(It is conceivable, therefore, that a person with a split-brain +personality might be both Republican and Democrat at the same time. If +you ask him whom he will vote for, he will give you the candidate of the +left brain, since the right brain cannot speak. But you can imagine the +chaos in the voting booth when he has to pull the lever with one hand.) + +WHO IS IN CHARGE?" +"WHO IS IN CHARGE? + +One person who has spent considerable time and done much research to +understand the problem of the subconscious mind is Dr. David +Eagleman, a neuroscientist at the Baylor College of Medicine. When I +interviewed him, I asked him, If most of our mental processes are + +subconscious, then why are we ignorant of this important fact? He gave +an example of a young king who inherits the throne and takes credit for +everything in the kingdom, but hasn’t the slightest clue about the +thousands of staff, soldiers, and peasants necessary to maintain the +throne." +"Our choice of politicians, marriage partners, friends, and future +occupations are all influenced by things that we are not conscious of. +(For example, it is an odd result, he says, that “people named Denise or +Dennis are disproportionately likely to become dentists, while people +named Laura or Lawrence are more likely to become lawyers, and +people with names like George or Georgina to become geologists.”) This +also means that what we consider to be “reality” is only an +approximation that the brain makes to fill in the gaps. Each of us sees +reality in a slightly different way. For example, he pointed out, “at least +15 percent of human females possess a genetic mutation that gives them +an extra (fourth) type of color photoreceptor—and this allows them to +discriminate between colors that look identical to the majority of us with +a mere three types of color photoreceptors.”" +"Clearly, the more we understand the mechanics of thought, the more +questions arise. Precisely what happens in the command center of the +mind when confronted with a rebellious shadow command center? What +do we mean by “consciousness” anyway, if it can be split in half? And +what is the relationship between consciousness and “self” and “self- +awareness”? + +If we can answer these difficult questions, then perhaps it will pave +the way for understanding nonhuman consciousness, the consciousness +of robots and aliens from outer space, for example, which may be + + entirely different from ours. + +So let us now propose a clear answer to this deceptively complex +question: What is consciousness? + +The mind of man is capable of anything ... because everything +is in it, all the past as well as all the future. + +—JOSEPH CONRAD + +Consciousness can reduce even the most fastidious thinker to +blabbering incoherence. + +—COLIN MCGINN + +2 CONSCIOUSNESS—A PHYSICIST’S VIEWPOINT" +"—COLIN MCGINN + +2 CONSCIOUSNESS—A PHYSICIST’S VIEWPOINT + +The idea of consciousness has intrigued philosophers for centuries, but +it has resisted a simple definition, even to this day. The philosopher +David Chalmers has cataloged more than twenty thousand papers +written on the subject; nowhere in science have so many devoted so +much to create so little consensus. The seventeenth-century thinker +Gottfried Leibniz once wrote, “If you could blow the brain up to the size +of a mill and walk about inside, you would not find consciousness.” + +Some philosophers doubt that a theory of consciousness is even +possible. They claim that consciousness can never be explained since an +object can never understand itself, so we don’t even have the mental +firepower to solve this perplexing question. Harvard psychologist Steven +Pinker writes, “We cannot see ultraviolet light. We cannot mentally +rotate an object in the fourth dimension. And perhaps we cannot solve +conundrums like free will and sentience.”" +"In fact, for most of the twentieth century, one of the dominant theories +of psychology, behaviorism, denied the importance of consciousness +entirely. Behaviorism is based on the idea that only the objective +behavior of animals and people is worthy of study, not the subjective, +internal states of the mind. + +Others have given up trying to define consciousness, and try simply to +describe it. Psychiatrist Giulio Tononi has said, “Everybody knows what +consciousness is: it is what abandons you every night when you fall into +dreamless sleep and returns the next morning when you wake up.” + + Although the nature of consciousness has been debated for centuries, +there has been little resolution. Given that physicists created many of the +inventions that have made the explosive advancements in brain science +possible, perhaps it will be useful to follow an example from physics in +reexamining this ancient question. + +HOW PHYSICISTS UNDERSTAND THE UNIVERSE" +"HOW PHYSICISTS UNDERSTAND THE UNIVERSE + +When a physicist tries to understand something, first he collects data and +then he proposes a “model,” a simplified version of the object he is +studying that captures its essential features. In physics, the model is +described by a series of parameters (e.g., temperature, energy, time). +Then the physicist uses the model to predict its future evolution by +simulating its motions. In fact, some of the world’s largest +supercomputers are used to simulate the evolution of models, which can +describe protons, nuclear explosions, weather patterns, the big bang, and +the center of black holes. Then you create a better model, using more +sophisticated parameters, and simulate it in time as well." +"For example, when Isaac Newton was puzzling over the motion of the +moon, he created a simple model that would eventually change the +course of human history: he envisioned throwing an apple in the air. The +faster you threw the apple, he reasoned, the farther it would travel. If +you threw it fast enough, in fact, it would encircle the Earth entirely, +and might even return to its original point. Then, Newton claimed, this +model represented the path of the moon, so the forces that guided the +motion of the apple circling the Earth were identical to the forces +guiding the moon." +"But the model, by itself, was still useless. The key breakthrough came +when Newton was able to use his new theory to simulate the future, to +calculate the future position of moving objects. This was a difficult +problem, requiring him to create an entirely new branch of mathematics, +called calculus. Using this new mathematics, Newton was then able to +predict the trajectory of not just the moon, but also Halley’s Comet and +the planets. Since then, scientists have used Newton’s laws to simulate +the future path of moving objects, from cannonballs, machines, +automobiles, and rockets to asteroids and meteors, and even stars and +galaxies. + +The success or failure of a model depends on how faithfully it +reproduces the basic parameters of the original. In this case, the basic +parameter was the location of the apple and the moon in space and time. +By allowing this parameter to evolve (i.e., letting time move forward), +Newton unlocked, for the first time in history, the action of moving" +"bodies, which is one of the most important discoveries in science. + +Models are useful, until they are replaced by even more accurate +models described by better parameters. Einstein replaced Newton’s + +picture of forces acting on apples and moons with a new model based on +a new parameter, the curvature of space and time. An apple moved not +because the Earth exerted a force on it, but because the fabric of space +and time was stretched by the Earth, so the apple was simply moving +along the surface of a curved space-time. From this, Einstein could then +simulate the future of the entire universe. Now, with computers, we can +run simulations of this model into the future and create gorgeous +pictures presenting the collisions of black holes. + +Let us now incorporate this basic strategy into a new theory of +consciousness. + +DEFINITION OF CONSCIOUSNESS" +"DEFINITION OF CONSCIOUSNESS + +I’ve taken bits and pieces from previous descriptions of consciousness in +the fields of neurology and biology in order to define consciousness as +follows: + +Consciousness is the process of creating a model of the world +using multiple feedback loops in various parameters (e.g., in +temperature, space, time, and in relation to others), in order to +accomplish a goal (e.g., find mates, food, shelter). + +I call this the “space-time theory of consciousness,” because it +emphasizes the idea that animals create a model of the world mainly in +relation to space, and to one another, while humans go beyond and +create a model of the world in relation to time, both forward and +backward." +"For example, the lowest level of consciousness is Level 0, where an +organism is stationary or has limited mobility and creates a model of its +place using feedback loops in a few parameters (e.g., temperature). For +example, the simplest level of consciousness is a thermostat. It +automatically turns on an air conditioner or heater to adjust the +temperature in a room, without any help. The key is a feedback loop +that turns on a switch if the temperature gets too hot or cold. (For +example, metals expand when heated, so a thermostat can turn on a +switch if a metal strip expands beyond a certain point.) + + Each feedback loop registers “one unit of consciousness,” so a +thermostat would have a single unit of Level 0 consciousness, that is, +Level 0:1." +"In this way, we can rank consciousness numerically, on the basis of +the number and complexity of the feedback loops used to create a model +of the world. Consciousness is then no longer a vague collection of +undefined, circular concepts, but a system of hierarchies that can be +ranked numerically. For example, a bacterium or a flower has many +more feedback loops, so they would have a higher level of Level 0 +consciousness. A flower with ten feedback loops (which measure +temperature, moisture, sunlight, gravity, etc.), would have a Level 0:10 +consciousness." +"Organisms that are mobile and have a central nervous system have +Level I consciousness, which includes a new set of parameters to +measure their changing location. One example of Level I consciousness +would be reptiles. They have so many feedback loops that they +developed a central nervous system to handle them. The reptilian brain +would have perhaps one hundred or more feedback loops (governing +their sense of smell, balance, touch, sound, sight, blood pressure, etc., +and each of these contains more feedback loops). For example, eyesight +alone involves a large number of feedback loops, since the eye can +recognize color, movement, shapes, light intensity, and shadows. +Similarly, the reptile’s other senses, such as hearing and taste, require +additional feedback loops. The totality of these numerous feedback loops +creates a mental picture of where the reptile is located in the world, and +where other animals (e.g., prey) are located as well. Level I" +"where other animals (e.g., prey) are located as well. Level I +consciousness, in turn, is governed mainly by the reptilian brain, located +in the back and center of the human head." +"Next we have Level II consciousness, where organisms create a model +of their place not only in space but also with respect to others (i.e., they +are social animals with emotions). The number of feedback loops for +Level II consciousness explodes exponentially, so it is useful to introduce +a new numerical ranking for this type of consciousness. Forming allies, +detecting enemies, serving the alpha male, etc., are all very complex +behaviors requiring a vastly expanded brain, so Level II consciousness +coincides with the formation of new structures of the brain in the form +of the limbic system. As noted earlier, the limbic system includes the + +hippocampus (for memories), amygdala (for emotions), and the +thalamus (for sensory information), all of which provide new parameters +for creating models in relation to others. The number and type of +feedback loops therefore change." +"We define the degree of Level II consciousness as the total number of +distinct feedback loops required for an animal to interact socially with +members of its grouping. Unfortunately, studies of animal consciousness +are extremely limited, so little work has been done to catalog all the +ways in which animals communicate socially with one another. But to a +crude first approximation, we can estimate Level II consciousness by +counting the number of fellow animals in its pack or tribe and then +listing the total number of ways in which the animal interacts +emotionally with each one. This would include recognizing rivals and +friends, forming bonds with others, reciprocating favors, building +coalitions, understanding your status and the social ranking of others, +respecting the status of your superiors, displaying your power over your +inferiors, plotting to rise on the social ladder, etc. (We exclude insects +from Level II, because although they have social relations with members" +"from Level II, because although they have social relations with members +of their hive or group, they have no emotions as far as we can tell.)" +"Despite the lack of empirical studies of animal behaviors, we can give +a very rough numerical rank to Level II consciousness by listing the total +number of distinct emotions and social behaviors that the animal can +exhibit. For example, if a wolf pack consists of ten wolves, and each wolf +interacts with all the others with fifteen different emotions and gestures, +then its level of consciousness, to a first approximation, is given by the +product of the two, or 150, so it would have Level 11:150 consciousness. +This number takes into account both the number of other animals it has +to interact with as well as the number of ways it can communicate with +each one. This number only approximates the total number of social +interactions that the animal can display, and will undoubtedly change as +we learn more about its behavior." +"(Of course, because evolution is never clean and precise, there are +caveats that we have to explain, such as the level of consciousness of +social animals that are solitary hunters. We will do so in the notes.) + +LEVEL III CONSCIOUSNESS: SIMULATING THE FUTURE + +With this framework for consciousness, we see that humans are not +unique, and that there is a continuum of consciousness. As Charles +Darwin once commented, “The difference between man and the higher +animals, great as it is, is certainly one of degree and not of kind.” But +what separates human consciousness from the consciousness of animals? +Humans are alone in the animal kingdom in understanding the concept +of tomorrow. Unlike animals, we constantly ask ourselves “What if?” +weeks, months, and even years into the future, so I believe that Level III +consciousness creates a model of its place in the world and then +simulates it into the future, by making rough predictions. We can +summarize this as follows:" +"Human consciousness is a specific form of consciousness that +creates a model of the world and then simulates it in time, by +evaluating the past to simulate the future. This requires +mediating and evaluating many feedback loops in order to +make a decision to achieve a goal. + +By the time we reach Level III consciousness, there are so many +feedback loops that we need a CEO to sift through them in order to +simulate the future and make a final decision. Accordingly, our brains +differ from those of other animals, especially in the expanded prefrontal +cortex, located just behind the forehead, which allows us to “see” into +the future." +"Dr. Daniel Gilbert, a Harvard psychologist, has written, “The greatest +achievement of the human brain is its ability to imagine objects and +episodes that do not exist in the realm of the real, and it is this ability +that allows us to think about the future. As one philosopher noted, the +human brain is an ‘anticipation machine,’ and ‘making the future’ is the +most important thing it does.” + +Using brain scans, we can even propose a candidate for the precise +area of the brain where simulation of the future takes place. Neurologist +Michael Gazzaniga notes that “area 10 (the internal granular layer IV), +in the lateral prefrontal cortex, is almost twice as large in humans as in +apes. Area 10 is involved with memory and planning, cognitive +flexibility, abstract thinking, initiating appropriate behavior, and +inhibiting inappropriate behavior, learning rules, and picking out" +"relevant information from what is perceived through the senses.” (For +this book, we will refer to this area, in which decision making is +concentrated, as the dorsolateral prefrontal cortex, although there is +some overlap with other areas of the brain.) + +Although animals may have a well-defined understanding of their +place in space and some have a degree of awareness of others, it is not +clear if they systematically plan for the future and have an +understanding of “tomorrow.” Most animals, even social animals with +well-developed limbic systems, react to situations (e.g., the presence of +predators or potential mates) by relying mainly on instinct, rather than +systematically planning into the future." +"For instance, mammals do not plan for the winter by preparing to +hibernate, but largely follow instinct as the temperature drops. There is +a feedback loop that regulates their hibernation. Their consciousness is +dominated by messages coming in from their senses. There is no +evidence that they systemically sift through various plans and schemes + + as they prepare to hibernate. Predators, when they use cunning and +disguise to stalk an unsuspecting prey, do anticipate future events, but +this planning is limited only to instinct and the duration of the hunt. +Primates are adept at devising short-term plans (e.g., finding food), but +there is no indication that they plan more than a few hours ahead." +"Humans are different. Although we do rely on instinct and emotions in +many situations, we also constantly analyze and evaluate information +from many feedback loops. We do this by running simulations sometimes +even beyond our own life span and even thousands of years into the +future. The point of running simulations is to evaluate various +possibilities to make the best decision to fulfill a goal. This occurs in the +prefrontal cortex, which allows us to simulate the future and evaluate +the possibilities in order to chart the best course of action. + +This ability evolved for several reasons. First, having the ability to +peer into the future has enormous evolutionary benefits, such as evading +predators and finding food and mates. Second, it allows us to choose +among several different outcomes and to select the best one." +"Third, the number of feedback loops explodes exponentially as we go +from Level 0 to Level I to Level II, so we need a “CEO” to evaluate all +these conflicting, competing messages. Instinct is no longer enough. +There has to be a central body that evaluates each of these feedback + +loops. This distinguishes human consciousness from that of the animals. +These feedback loops are evaluated, in turn, by simulating them into the +future to obtain the best outcome. If we didn’t have a CEO, chaos would +ensue and we would have sensory overload. + +A simple experiment can demonstrate this. David Eagleman describes +how you can take a male stickleback fish and have a female fish trespass +on its territory. The male gets confused, because it wants to mate with +the female, but it also wants to defend its territory. As a result, the male +stickleback fish will simultaneously attack the female while initiating +courtship behavior. The male is driven into a frenzy, trying to woo and +kill the female at the same time." +"This works for mice as well. Put an electrode in front of a piece of +cheese. If the mouse gets too close, the electrode will shock it. One +feedback loop tells the mouse to eat the cheese, but another one tells the +mouse to stay away and avoid being shocked. By adjusting the location +of the electrode, you can get the mouse to oscillate, torn between two +conflicting feedback loops. While a human has a CEO in its brain to +evaluate the pros and cons of the situation, the mouse, governed by two +conflicting feedback loops, goes back and forth. (This is like the proverb +about the donkey that starves to death because it is placed between two + + equal bales of hay.)" +"equal bales of hay.) + +Precisely how does the brain simulate the future? The human brain is +flooded by a large amount of sensory and emotional data. But the key is +to simulate the future by making causal links between events—that is, if +A happens, then B happens. But if B happens, then C and D might result. +This sets off a chain reaction of events, eventually creating a tree of +possible cascading futures with many branches. The CEO in the +prefrontal cortex evaluates the results of these causal trees in order to +make the ultimate decision. + +Let’s say you want to rob a bank. How many realistic simulations of +this event can you make? To do this, you have to think of the various +causal links involving the police, bystanders, alarm systems, relations +with fellow criminals, traffic conditions, the DA’s office, etc. For a +successful simulation of the robbery, hundreds of causal links may have +to be evaluated." +"It is also possible to measure this level of consciousness numerically. +Let’s say that a person is given a series of different situations like the one + +above and is asked to simulate the future of each. The sum total number +of causal links that the person can make for all these situations can be +tabulated. (One complication is that there are an unlimited number of +causal links that a person might make for a variety of conceivable +situations. To get around this complication, we divide this number by +the average number of causal links obtained from a large control group. +Like the IQ exam, one may multiply this number by 100. So a person’s +level of consciousness, for example, might be Level 111:100, meaning that +the person can simulate future events just like the average person.) + +We summarize these levels of consciousness in the following diagram: + +LEVELS OF CONSCIOUSNESS FOR DIFFERENT SPECIES + +LEVEL + +SPECIES + +PARAMETER + +BRAIN STRUCTURE + +0 + +| Plants + + | Temperature, sunshine + +None + +1" +"SPECIES + +PARAMETER + +BRAIN STRUCTURE + +0 + +| Plants + + | Temperature, sunshine + +None + +1 + +Reptiles + +j Space + +Brain stem + +II + +| Mammals + +| Social relations + +j Limbic system + +III + +j Humans + +| Time (esp. future) + +j Prefrontal cortex + +Space-time theory of consciousness. We define consciousness as the process of creating a model of the +world using +multiple feedback loops in various parameters (e.g., in space, time, and in relation to others), in order to +accomplish a +goal. Human consciousness is a particular type that involves mediating between these feedback loops +by simulating the + +future and evaluating the past." +"future and evaluating the past. + +(Notice that these categories correspond to the rough evolutionary +levels we find in nature—e.g., reptiles, mammals, and humans. However, +there are also gray areas, such as animals that might possess tiny aspects +of different levels of consciousness, animals that do some rudimentary +planning, or even single cells that communicate with one another. This +chart is meant only to give you the larger, global picture of how +consciousness is organized across the animal kingdom.) + +WHAT IS HUMOR? WHY DO WE HAVE EMOTIONS? + + All theories have to be falsifiable. The challenge for the space-time +theory of consciousness is to explain all aspects of human consciousness" +"in this framework. It can be falsified if there are patterns of thought that +cannot be brought into this theory. A critic might say that surely our +sense of humor is so quixotic and ephemeral that it is beyond +explanation. We spend a great deal of time laughing with our friends or +at comedians, yet it seems that humor has nothing to do with our +simulations of the future. But consider this. Much of humor, such as +telling a joke, depends on the punch line." +"When hearing a joke, we can’t help but simulate the future and +complete the story ourselves (even if we’re unaware that we’re doing +so). We know enough about the physical and social world that we can +anticipate the ending, so we burst out with laughter when the punch line +gives us a totally unexpected conclusion. The essence of humor is when +our simulation of the future is suddenly disrupted in surprising ways. +(This was historically important for our evolution since success depends, +in part, on our ability to simulate future events. Since life in the jungle is +full of unanticipated events, anyone who can foresee unexpected +outcomes has a better chance at survival. In this way, having a well- +developed sense of humor is actually one indication of our Level III +consciousness and intelligence; that is, the ability to simulate the future.)" +"For example, W. C. Fields was once asked a question about social +activities for youth. He was asked, “Do you believe in clubs for young +people?” He replied, “Only when kindness fails.” + +The joke has a punch line only because we mentally simulate a future +in which children have social clubs, while W. C. Fields simulates a +different future involving clubs as a weapon. (Of course, if a joke is +deconstructed, it loses its power, since we have already simulated +various possible futures in our minds.) + +This also explains what every comedian knows: timing is the key to +humor. If the punch line is delivered too quickly, then the brain hasn’t +had time to simulate the future, so there is no experience of the +unanticipated. If the punch line is delivered too late, the brain has +already had time to simulate various possible futures, so again the punch +line loses the element of surprise." +"(Humor has other functions, of course, such as bonding with fellow +members of our tribe. In fact, we use our sense of humor as a way to size +up the character of others. This, in turn, is essential to determine our +status within society. So in addition, laughter helps define our position + + in the social world, i.e., Level II consciousness.) + +WHY DO WE GOSSIP AND PLAY? + +Even seemingly trivial activities, such as engaging in idle gossip or +horsing around with our friends, must be explained in this framework. +(If a Martian were to visit a supermarket checkout line and view the +huge display of gossip magazines, it might conclude that gossip is the +main activity of humans. This observation would not be far off.)" +"Gossiping is essential for survival because the complex mechanics of +social interactions are constantly changing, so we have to make sense of +this ever-shifting social terrain. This is Level II consciousness at work. +But once we hear a piece of gossip, we immediately run simulations to +determine how this will affect our own standing in the community, +which moves us to Level III consciousness. Thousands of years ago, in +fact, gossip was the only way to obtain vital information about the tribe. +One’s very life often depended on knowing the latest gossip." +"Something as superfluous as “play” is also an essential feature of +consciousness. If you ask children why they like to play, they will say, +“Because it’s fun.” But that invites the next question: What is fun? +Actually, when children play, they are often trying to reenact complex +human interactions in simplified form. Human society is extremely +sophisticated, much too involved for the developing brains of young +children, so children run simplified simulations of adult society, playing +games such as doctor, cops and robber, and school. Each game is a +model that allows children to experiment with a small segment of adult +behavior and then run simulations into the future. (Similarly, when +adults engage in play, such as a game of poker, the brain constantly +creates a model of what cards the various players possess, and then +projects that model into the future, using previous data about people’s +personality, ability to bluff, etc. The key to games like chess, cards, and" +"personality, ability to bluff, etc. The key to games like chess, cards, and +gambling is the ability to simulate the future. Animals, which live +largely in the present, are not as good at games as humans are, +especially if they involve planning. Infant mammals do engage in a form +of play, but this is more for exercise, testing one another, practicing +future battles, and establishing the coming social pecking order rather" +"than simulating the future.) + +My space-time theory of consciousness might also shed light on + + another controversial topic: intelligence. Although IQ exams claim to +measure “intelligence,” IQ exams actually give no definition of +intelligence in the first place. In fact, a cynic may claim, with some +justification, that IQ is a measure of “how well you do on IQ exams,” +which is circular. In addition, IQ exams have been criticized for being +too culturally biased. In this new framework, however, intelligence may +be viewed as the complexity of our simulations of the future. Hence, a +master criminal, who may be a dropout and functionally illiterate and +score dismally low on an IQ exam, may also far outstrip the ability of the +police. Outwitting the cops may entail simply being able to run more +sophisticated simulations of the future. + +LEVEL I: STREAM OF CONSCIOUSNESS" +"LEVEL I: STREAM OF CONSCIOUSNESS + +Humans are probably alone on this planet in being able to operate on all +levels of consciousness. Using MRI scans, we can break down the +different structures involved in each level of consciousness." +"For us, Level I stream of consciousness is largely the interplay between +the prefrontal cortex and the thalamus. When taking a leisurely stroll in +the park, we are aware of the smells of the plants, the sensation of a +gentle breeze, the visual stimuli from the sun, and so on. Our senses send +signals to the spinal cord, the brain stem, and then to the thalamus, +which operates like a relay station, sorting out the stimuli and sending +them on to the various cortices of the brain. The images of the park, for +example, are sent to the occipital cortex in the back of the brain, while +the sense of touch from the wind is sent to the parietal lobe. The signals +are processed in appropriate cortices, and then sent to the prefrontal +cortex, where we finally become conscious of all these sensations. + +This is illustrated in Figure 7. + +LEVEL II: FINDING OUR PLACE IN SOCIETY" +"This is illustrated in Figure 7. + +LEVEL II: FINDING OUR PLACE IN SOCIETY + +While Level I consciousness uses sensations to create a model of our +physical location in space, Level II consciousness creates a model of our + +place in society. + +Let’s say we are going to an important cocktail party, in which people +essential to our job will be present. As we scan the room, trying to +identify people from our workplace, there is an intense interplay +between the hippocampus (which processes memories), the amygdala +(which processes emotions), and the prefrontal cortex (which puts all + + this information together). + +Figure 7. In Level I consciousness, sensory information travels through the brain stem, past the +thalamus, onto the various +cortices of the brain, and finally to the prefrontal cortex. Thus this stream of Level I consciousness is +created by the flow +of information from the thalamus to the prefrontal cortex, (illustration credit 2.1)" +"With each image, the brain automatically attaches an emotion, such as +happiness, fear, anger, or jealousy, and processes the emotion in the + +amygdala. + +If you spot your chief rival, whom you suspect of stabbing you in the +back, the emotion of fear is processed by the amygdala, which sends an +urgent message to the prefrontal cortex, alerting it to possible danger. At +the same time, signals are sent to your endocrine system to start +pumping adrenaline and other hormones into the blood, thereby +increasing your heartbeat and preparing you for a possible fight-or-flight +response. + +This is illustrated in Figure 8." +"This is illustrated in Figure 8. + +But beyond simply recognizing other people, the brain has the +uncanny ability to guess what other people are thinking about. This is +called the Theory of Mind, a theory first proposed by Dr. David Premack +of the University of Pennsylvania, which is the ability to infer the +thoughts of others. In any complex society, anyone with the ability to +correctly guess the intentions, motives, and plans of other people has a +tremendous survival advantage over those who can’t. The Theory of +Mind allows you to form alliances with others, isolate your enemies, and +solidify your friendships, which vastly increases your power and chances +of survival and mating. Some anthropologists even believe that the +mastery of the Theory of Mind was essential in the evolution of the +brain." +"Figure 8. Emotions originate and are processed in the limbic system. In Level II consciousness, we are +continually +bombarded with sensory information, but emotions are rapid-fire responses to emergencies from the +limbic system that + + do not need permission from the prefrontal cortex. The hippocampus is also important for processing +memories. So Level +II consciousness, at its core, involves the reaction of the amygdala, hippocampus, and prefrontal cortex, +(illustration + +credit 2.2) + +But how is the Theory of Mind accomplished? One clue came in 1996, +with the discovery of “mirror neurons” by Drs. Giacomo Rizzolatti, +Leonardo Fogassi, and Vittorio Gallese. These neurons fire when you are +performing a certain task and also when you see someone else +performing that same task. (Mirror neurons also fire for emotions as well +as physical acts. If you feel a certain emotion, and think another is +feeling that same emotion, then the mirror neurons will fire.)" +"Mirror neurons are essential for mimicry and also for empathy, giving + +us the ability not only to copy the complex tasks performed by others +but also to experience the emotions that person must be feeling. Mirror +neurons were thus probably essential for our evolution as human beings, +since cooperation is essential for holding the tribe together." +"Mirror neurons were first found in the premotor areas of monkey +brains. But since then, they have been found in humans in the prefrontal +cortex. Dr. V. S. Ramachandran believes that mirror neurons were +essential in giving us the power of self-awareness and concludes, “I +predict that mirror neurons will do for psychology what DNA did for +biology: they will provide a unifying framework and help explain a host +of mental abilities that have hitherto remained mysterious and +inaccessible to experiments.” (We should point out, however, that all +scientific results have to be tested and reconfirmed. There is no doubt +that certain neurons are performing this crucial behavior involved with +empathy, mimicry, etc., but there is some debate about the identity of +these mirror neurons. For example, some critics claim that perhaps these +behaviors are common to many neurons, and that there is not a single +class of neurons dedicated to this behavior.) + +LEVEL III: SIMULATING THE FUTURE" +"LEVEL III: SIMULATING THE FUTURE + +The highest level of consciousness, which is associated primarily with +Homo sapiens, is Level III consciousness, in which we take our model of +the world and then run simulations into the future. We do this by +analyzing past memories of people and events, and then simulating the + + future by making many causal links to form a “causal” tree. As we look +at the various faces at the cocktail party, we begin to ask ourselves +simple questions: How can this individual help me? How will the gossip +floating in the room play out in the future? Is anyone out to get me? + +Let’s say that you just lost your job and you are desperately looking +for a new one. In this case, as you talk to various people at the cocktail +party, your mind is feverishly simulating the future with each person +you talk to. You ask yourself, How can I impress this person? What +topics should I bring out to present my best case? Can he offer me a job?" +"Figure 9. Simulating the future, the heart of Level III consciousness, is mediated by the dorsolateral +prefrontal cortex, the +CEO of the brain, with competition between the pleasure center and the orbitofrontal cortex (which acts +to check our +impulses). This roughly resembles the outline given by Freud of the struggle between our conscience +and desires. The +actual process of simulating the future takes place when the prefrontal cortex accesses the memories of +the past in order + +to approximate future events, (illustration credit 2.3)" +"to approximate future events, (illustration credit 2.3) + +Recent brain scans have shed partial light on how the brain simulates +the future. These simulations are done mainly in the dorsolateral +prefrontal cortex, the CEO of the brain, using memories of the past. On +one hand, simulations of the future may produce outcomes that are +desirable and pleasurable, in which case the pleasure centers of the brain +light up (in the nucleus accumbens and hypothalamus). On the other +hand, these outcomes may also have a downside to them, so the +orbitofrontal cortex kicks in to warn us of possible dangers. There is a + +struggle, then, between different parts of the brain concerning the +future, which may have desirable and undesirable outcomes. Ultimately +it is the dorsolateral prefrontal cortex that mediates between these and +makes the final decisions. (See Figure 9.) (Some neurologists have +pointed out that this struggle resembles, in a crude way, the dynamics +between Freud’s ego, id, and superego.)" +"THE MYSTERY OF SELF-AWARENESS + + If the space-time theory of consciousness is correct, then it also gives us +a rigorous definition of self-awareness. Instead of vague, circular +references, we should be able to give a definition that is testable and +useful. We’ll define self-awareness as follows: + +Self-awareness is creating a model of the world and simulating + +the future in which you appear. + +Animals therefore have some self-awareness, since they have to know +where they are located if they are going to survive and mate, but it is +limited largely by instinct. + +When most animals are placed in front of a mirror, they either ignore +it or attack it, not realizing that it is an image of themselves. (This is +called the “mirror test,” which goes all the way back to Darwin.) +However, animals like elephants, the great apes, bottlenose dolphins, +orcas, and European magpies can figure out that the image they see in +the mirror represents themselves." +"Humans, however, take a giant step forward and constantly run future +simulations in which we appear as a principal actor. We constantly +imagine ourselves faced with different situations—going on a date, +applying for a job, changing careers—none of which is determined by +instinct. It is extremely difficult to stop your brain from simulating the +future, though elaborate methods have been devised (for instance, +meditation) to attempt to do so. + +Daydreaming, as an example, consists largely of our acting out +different possible futures to attain a goal. Since we pride ourselves in +knowing our limitations and strengths, it is not hard to put ourselves + +inside the model and hit the “play” button so we begin to act out +hypothetical scenarios, like being an actor in a virtual play. + +WHERE AM “I”?" +"WHERE AM “I”? + +There is probably a specific part of the brain whose job it is to unify the +signals from the two hemispheres to create a smooth, coherent sense of +self. Dr. Todd Heatherton, a psychologist at Dartmouth College, believes +that this region is located within the prefrontal cortex, in what is called +the medial prefrontal cortex. Biologist Dr. Carl Zimmer writes, “The +medial prefrontal cortex may play the same role for the self as the +hippocampus plays in memory ... [it] could be continually stitching +together a sense of who we are.” In other words, this may be the +gateway to the concept of “I,” the central region of the brain that fuses, + + integrates, and concocts a unified narrative of who we are. (This does +not mean, however, that the medial prefrontal cortext is the homunculus +sitting in our brain that controls everything.)" +"If this theory is true, then the resting brain, when we are idly +daydreaming about our friends and ourselves, should be more active +than normal, even when other parts of the brain’s sensory regions are +quiet. In fact, brain scans bear this out. Dr. Heatherton concludes, “Most +of the time we daydream—we think about something that happened to +us or what we think about other people. All this involves self-reflection.” + +The space-time theory says that consciousness is cobbled together +from many subunits of the brain, each competing with the others to +create a model of the world, and yet our consciousness feels smooth and +continuous. How can this be, when we all have the feeling that our “self” +is uninterrupted and always in charge?" +"In the previous chapter, we met the plight of split-brain patients, who +sometimes struggle with alien hands that literally have a mind of their +own. It does appear that there are two centers of consciousness living +within the same brain. So how does all this create the sense that we have +a unified, cohesive “self’ existing within our brains? + +I asked one person who may have the answer: Dr. Michael Gazzaniga, +who has spent several decades studying the strange behavior of split- +brain patients. He noticed that the left brain of split-brain patients, when" +"confronted with the fact that there seem to be two separate centers of +consciousness residing in the same skull, would simply make up strange +explanations, no matter how silly. He told me that, when presented with +an obvious paradox, the left brain will “confabulate” an answer to +explain inconvenient facts. Dr. Gazzaniga believes that this gives us the +false sense that we are unified and whole. He calls the left brain the +“interpreter,” which is constantly thinking up ideas to paper over +inconsistencies and gaps in our consciousness." +"For example, in one experiment, he flashed the word “red” to just the +left brain of a patient, and the word “banana” to just the right brain. +(Notice that the dominant left brain therefore does not know about the +banana.) Then the subject was asked to pick up a pen with his left hand +(which is governed by the right brain) and draw a picture. Naturally he +drew a picture of a banana. Remember that the right brain could do this, +because it had seen the banana, but the left brain had no clue that the +banana had been flashed to the right brain. + +Then he was asked why he had drawn the banana. Because only the +left brain controls speech, and because the left brain did not know" +"anything about a banana, the patient should have said, “I don’t know.” +Instead he said, “It is easiest to draw with this hand because this hand +can pull down easier.” Dr. Gazzaniga noted that the left brain was trying +to find some excuse for this inconvenient fact, even though the patient +was clueless about why his right hand drew the banana. + +Dr. Gazzaniga concludes, “It is the left hemisphere that engages in the +human tendency to find order in chaos, that tries to fit everything into a +story and put it into a context. It seems that it is driven to hypothesize +about the structure of the world even in the face of evidence that no +pattern exists.”" +"This is where our sense of a unified “self’ comes from. Although +consciousness is a patchwork of competing and often contradictory +tendencies, the left brain ignores inconsistencies and papers over +obvious gaps in order to give us a smooth sense of a single “I.” In other +words, the left brain is constantly making excuses, some of them +harebrained and preposterous, to make sense of the world. It is +constantly asking “Why?” and dreaming up excuses even if the question +has no answer. + +(There is probably an evolutionary reason that we evolved our split" +"(There is probably an evolutionary reason that we evolved our split + +brains. A seasoned CEO will often encourage his aides to take opposing +sides of an issue, to encourage thorough and thoughtful debate. +Oftentimes, the correct view emerges out of intense interaction with +incorrect ideas. Similarly, the two halves of the brain complement each +other, offering pessimistic/optimistic or analytical/holistic analysis of +the same idea. The two halves of the brain therefore play off each other. +Indeed, as we shall see, certain forms of mental illness may arise when +this interplay between the two brains goes awry.)" +"Now that we have a working theory of consciousness, the time has come +to utilize it to understand how neuroscience will evolve in the future. +There is a vast and remarkable set of experiments now being done in +neuroscience that are fundamentally altering the entire scientific +landscape. Using the power of electromagnetism, scientists can now +probe people’s thoughts, send telepathic messages, telekinetically control +objects around us, record memories, and perhaps enhance our +intelligence. + +Perhaps the most immediate and practical application of this new +technology is something once considered to be hopelessly impossible: +telepathy. + + BOOK II MIND OVER MATTER + +The brain, like it or not, is a machine. Scientists have come to +that conclusion, not because they are mechanistic killjoys, but +because they have amassed evidence that every aspect of +consciousness can be tied to the brain. + +—STEVEN PINKER + +3 TELEPATHY A PENNY FOR YOUR THOUGHTS" +"—STEVEN PINKER + +3 TELEPATHY A PENNY FOR YOUR THOUGHTS + +Harry Houdini, some historians believe, was the greatest magician +who ever lived. His breathtaking escapes from locked, sealed chambers +and death-defying stunts left audiences gasping. He could make people +disappear and then reemerge in the most unexpected places. And he +could read people’s minds. + +Or at least it seemed that way. + +Houdini took pains to explain that everything he did was an illusion, a +series of clever sleight-of-hand tricks. Mind reading, he would remind +people, was impossible. He was so outraged that unscrupulous magicians +would cheat wealthy patrons by performing cheap parlor tricks and +seances that he even went around the country exposing fakes by +pledging he could duplicate any feat of mind reading performed by these +charlatans. He was even on a committee organized by Scientific American +that offered a generous reward to anyone who could positively prove +they had psychic power. (No one ever picked up the reward.)" +"Houdini believed that telepathy was impossible. But science is proving +Houdini wrong. + +Telepathy is now the subject of intense research at universities around +the world, where scientists have already been able to use advanced +sensors to read individual words, images, and thoughts in a person’s +brain. This could alter the way we communicate with stroke and +accident victims who are “locked in” their bodies, unable to articulate +their thoughts except through blinks. But that’s just the start. Telepathy +might also radically change the way we interact with computers and the +outside world. + +Indeed, in a recent “Next 5 in 5 Forecast,” which predicts five +revolutionary developments in the next five years, IBM scientists claimed +that we will be able to mentally communicate with computers, perhaps + + replacing the mouse and voice commands. This means using the power +of the mind to call people on the phone, pay credit card bills, drive cars," +"make appointments, create beautiful symphonies and works of art, etc. +The possibilities are endless, and it seems that everyone—from computer +giants, educators, video game companies, and music studios to the +Pentagon—is converging on this technology." +"True telepathy, found in science-fiction and fantasy novels, is not +possible without outside assistance. As we know, the brain is electrical. +In general, anytime an electron is accelerated, it gives off +electromagnetic radiation. The same holds true for electrons oscillating +inside the brain, which broadcasts radio waves. But these signals are too +faint to be detected by others, and even if we could perceive these radio +waves, it would be difficult to make sense of them. Evolution has not +given us the ability to decipher this collection of random radio signals, +but computers can. Scientists have been able to get crude +approximations of a person’s thoughts using EEG scans. Subjects would +put on a helmet with EEG sensors and concentrate on certain pictures— +say, the image of a car. The EEG signals were then recorded for each +image and eventually a rudimentary dictionary of thought was created, +with a one-to-one correspondence between a person’s thoughts and the" +"with a one-to-one correspondence between a person’s thoughts and the +EEG image. Then, when a person was shown a picture of another car, +the computer would recognize the EEG pattern as being from a car." +"The advantage of EEG sensors is that they are noninvasive and quick. +You simply put a helmet containing many electrodes onto the surface of +the brain and the EEG can rapidly identify signals that change every +millisecond. But the problem with EEG sensors, as we have seen, is that +electromagnetic waves deteriorate as they pass through the skull, and it +is difficult to locate their precise source. This method can tell if you are +thinking of a car or a house, but it cannot re-create an image of the car. +That is where Dr. Jack Gallant’s work comes in. + +VIDEOS OF THE MIND + +The epicenter for much of this research is the University of California at +Berkeley, where I received my own Ph.D. in theoretical physics years +ago. I had the pleasure of touring the laboratory of Dr. Gallant, whose +group has accomplished a feat once considered to be impossible: +videotaping people’s thoughts. “This is a major leap forward + +reconstructing internal imagery. We are opening a window into the" +"reconstructing internal imagery. We are opening a window into the + + movies in our mind,” says Gallant. + +When I visited his laboratory, the first thing I noticed was the team of +young, eager postdoctoral and graduate students huddled in front of +their computer screens, looking intently at video images that were +reconstructed from someone’s brain scan. Talking to Gallant’s team, you +feel as though you are witnessing scientific history in the making." +"Gallant explained to me that first the subject lies flat on a stretcher, +which is slowly inserted headfirst into a huge, state-of-the-art MRI +machine, costing upward of $3 million. The subject is then shown +several movie clips (such as movie trailers readily available on +YouTube). To accumulate enough data, the subject has to sit motionless +for hours watching these clips, a truly arduous task. I asked one of the +postdocs, Dr. Shinji Nishimoto, how they found volunteers who were +willing to lie still for hours on end with only fragments of video footage +to occupy the time. He said the people in the room, the grad students +and postdocs, volunteered to be guinea pigs for their own research." +"As the subject watches the movies, the MRI machine creates a 3-D +image of the blood flow within the brain. The MRI image looks like a +vast collection of thirty thousand dots, or voxels. Each voxel represents a +pinpoint of neural energy, and the color of the dot corresponds to the +intensity of the signal and blood flow. Red dots represent points of large +neural activity, while blue dots represent points of less activity. (The +final image looks very much like thousands of Christmas lights in the +shape of the brain. Immediately you can see that the brain is +concentrating most of its mental energy in the visual cortex, which is +located at the back of the brain, while watching these videos.)" +"Gallant’s MRI machine is so powerful it can identify two to three +hundred distinct regions of the brain and, on average, can take snapshots +that have one hundred dots per region of the brain. (One goal for future +generations of MRI technology is to provide an even sharper resolution +by increasing the number of dots per region of the brain.) + +At first, this 3-D collection of colored dots looks like gibberish. But +after years of research, Dr. Gallant and his colleagues have developed a +mathematical formula that begins to find relationships between certain +features of a picture (edges, textures, intensity, etc.) and the MRI voxels. +For example, if you look at a boundary, you’ll notice it’s a region" +"separating lighter and darker areas, and hence the edge generates a +certain pattern of voxels. By having subject after subject view such a +large library of movie clips, this mathematical formula is refined, +allowing the computer to analyze how all sorts of images are converted +into MRI voxels. Eventually the scientists were able to ascertain a direct + + correlation between certain MRI patterns of voxels and features within +each picture." +"correlation between certain MRI patterns of voxels and features within +each picture. + +At this point, the subject is then shown another movie trailer. The +computer analyzes the voxels generated during this viewing and re¬ +creates a rough approximation of the original image. (The computer +selects images from one hundred movie clips that most closely resemble +the one that the subject just saw and then merges images to create a +close approximation.) In this way, the computer is able to create a fuzzy +video of the visual imagery going through your mind. Dr. Gallant’s +mathematical formula is so versatile that it can take a collection of MRI +voxels and convert it into a picture, or it can do the reverse, taking a +picture and then converting it to MRI voxels." +"I had a chance to view the video created by Dr. Gallant’s group, and it +was very impressive. Watching it was like viewing a movie with faces, +animals, street scenes, and buildings through dark glasses. Although you +could not see the details within each face or animal, you could clearly +identify the kind of object you were seeing." +"Not only can this program decode what you are looking at, it can also +decode imaginary images circulating in your head. Let’s say you are +asked to think of the Mona Lisa. We know from MRI scans that even +though you’re not viewing the painting with your eyes, the visual cortex +of your brain will light up. Dr. Gallant’s program then scans your brain +while you are thinking of the Mona Lisa and flips through its data files of +pictures, trying to find the closest match. In one experiment I saw, the +computer selected a picture of the actress Salma Hayek as the closest +approximation to the Mona Lisa. Of course, the average person can easily +recognize hundreds of faces, but the fact that the computer analyzed an +image within a person’s brain and then picked out this picture from +millions of random pictures at its disposal is still impressive." +"The goal of this whole process is to create an accurate dictionary that +allows you to rapidly match an object in the real world with the MRI +pattern in your brain. In general, a detailed match is very difficult and + +will take years, but some categories are actually easy to read just by +flipping through some photographs. Dr. Stanislas Dehaene of the College +de France in Paris was examining MRI scans of the parietal lobe, where +numbers are recognized, when one of his postdocs casually mentioned +that just by quickly scanning the MRI pattern, he could tell what number +the subject was looking at. In fact, certain numbers created distinctive +patterns on the MRI scan. He notes, “If you take 200 voxels in this area, +and look at which of them are active and which are inactive, you can +construct a machine-learning device that decodes which number is being +held in memory.”" +"This leaves open the question of when we might be able to have +picture-quality videos of our thoughts. Unfortunately, information is lost +when a person is visualizing an image. Brain scans corroborate this. +When you compare the MRI scan of the brain as it is looking at a flower +to an MRI scan as the brain is thinking about a flower, you immediately +see that the second image has far fewer dots than the first. So although +this technology will vastly improve in the coming years, it will never be +perfect. (I once read a short story in which a man meets a genie who +offers to create anything that the person can imagine. The man +immediately asks for a luxury car, a jet plane, and a million dollars. At +first, the man is ecstatic. But when he looks at these items in detail, he +sees that the car and the plane have no engines, and the image on the +cash is all blurred. Everything is useless. This is because our memories +are only approximations of the real thing.)" +"But given the rapidity with which scientists are beginning to decode +the MRI patterns in the brain, will we soon be able to actually read +words and thoughts circulating in the mind? + +READING THE MIND + +In fact, in a building next to Gallant’s laboratory, Dr. Brian Pasley and +his colleagues are literally reading thoughts—at least in principle. One of +the postdocs there, Dr. Sara Szczepanski, explained to me how they are +able to identify words inside the mind. + +The scientists used what is called ECOG (electrocorticogram) +technology, which is a vast improvement over the jumble of signals that + +EEG scans produce. ECOG scans are unprecedented in accuracy and +resolution, since signals are directly recorded from the brain and do not +pass through the skull. The flipside is that one has to remove a portion +of the skull to place a mesh, containing sixty-four electrodes in an eight- +by-eight grid, directly on top of the exposed brain." +"Luckily they were able to get permission to conduct experiments with +ECOG scans on epileptic patients, who were suffering from debilitating +seizures. The ECOG mesh was placed on the patients’ brains while open- +brain surgery was being performed by doctors at the nearby University +of California at San Francisco. + +As the patients hear various words, signals from their brains pass +through the electrodes and are then recorded. Eventually a dictionary is +formed, matching the word with the signals emanating from the + + electrodes in the brain. Later, when a word is uttered, one can see the +same electrical pattern. This correspondence also means that if one is +thinking of a certain word, the computer can pick up the characteristic +signals and identify it." +"With this technology, it might be possible to have a conversation that +takes place entirely telepathically. Also, stroke victims who are totally +paralyzed may be able to “talk” through a voice synthesizer that +recognizes the brain patterns of individual words. + +Not surprisingly, BMI (brain-machine interface) has become a hot +field, with groups around the country making significant breakthroughs. +Similar results were obtained by scientists at the University of Utah in +2011. They placed grids, each containing sixteen electrodes, over the +facial motor cortex (which controls movements of the mouth, lips, +tongue, and face) and Wernicke’s area, which processes information +about language." +"The person was then asked to say ten common words, such as “yes” +and “no,” “hot” and “cold,” “hungry” and “thirsty,” “hello” and “good¬ +bye,” and “more” and “less.” Using a computer to record the brain +signals when these words were uttered, the scientists were able to create +a rough one-to-one correspondence between spoken words and computer +signals from the brain. Later, when the patient voiced certain words, +they were able to correctly identify each one with an accuracy ranging +from 76 percent to 90 percent. The next step is to use grids with 121 +electrodes to get better resolution. + +In the future, this procedure may prove useful for individuals suffering +from strokes or paralyzing illnesses such as Lou Gehrig’s disease, who +would be able to speak using the brain-to-computer technique. + +TYPING WITH THE MIND" +"TYPING WITH THE MIND + +At the Mayo Clinic in Minnesota, Dr. Jerry Shih has hooked up epileptic +patients via ECOG sensors so they can learn how to type with the mind. +The calibration of this device is simple. The patient is first shown a +series of letters and is told to focus mentally on each symbol. A +computer records the signals emanating from the brain as it scans each +letter. As with the other experiments, once this one-to-one dictionary is +created, it is then a simple matter for the person to merely think of the +letter and for the letter to be typed on a screen, using only the power of +the mind. + +Dr. Shih, the leader of this project, says that the accuracy of his + + machine is nearly 100 percent. Dr. Shih believes that he can next create +a machine to record images, not just words, that patients conceive in +their minds. This could have applications for artists and architects, but +the big drawback of ECOG technology, as we have mentioned, is that it +requires opening up patients’ brains." +"Meanwhile, EEG typewriters, because they are noninvasive, are +entering the marketplace. They are not as accurate or precise as ECOG +typewriters, but they have the advantage that they can be sold over the +counter. Guger Technologies, based in Austria, recently demonstrated an +EEG typewriter at a trade show. According to their officials, it takes only +ten minutes or so for people to learn how to use this machine, and they +can then type at the rate of five to ten words per minute. + +TELEPATHIC DICTATION AND MUSIC + +The next step might be to transmit entire conversations, which could +rapidly speed up telepathic transmission. The problem, however, is that +it would require making a one-to-one map between thousands of words +and their EEG, MRI, or ECOG signals. But if one can, for example, +identify the brain signals of several hundred select words, then one" +"might be able to rapidly transmit words found in a common +conversation. This means that one would think of the words in entire +sentences and paragraphs of a conversation and a computer would print +them out. + +This could be extremely useful for journalists, writers, novelists, and +poets, who could simply think and have a computer take dictation. The +computer would also become a mental secretary. You would mentally +give instructions to the robo-secretary about a dinner, plane trip, or +vacation, and it would fill in all the details about the reservations." +"Not only dictation but also music may one day be transcribed in this +way. Musicians would simply hum a few melodies in their head and a +computer would print them out, in musical notation. To do this, you +would ask someone to mentally hum a series of notes, which would +generate certain electrical signals for each one. A dictionary would again +be created in this way, so that when you think of a musical note, the +computer would print it out in musical notation. + +In science fiction, telepaths often communicate across language +barriers, since thoughts are considered to be universal. However, this +might not be true. Emotions and feelings may well be nonverbal and +universal, so that one could telepathically send them to anyone, but + + rational thinking is so closely tied to language that it is very unlikely +that complex thoughts could be sent across language barriers. Words will +still be sent telepathically in their original language. + +TELEPATHY HELMETS" +"TELEPATHY HELMETS + +In science fiction, we also often encounter telepathy helmets. Put them +on, and—presto!—you can read other people’s minds. The U.S. Army, in +fact, has expressed interest in this technology. In a firefight, with +explosions going off and bullets whizzing overhead, a telepathy helmet +could be a lifesaver, since it can be difficult to communicate orders amid +the sound and fury of the battlefield. (I can personally testify to this. +Years ago, during the Vietnam War, I served in the U.S. Infantry at Fort +Benning, outside Atlanta, Georgia. During machine-gun training, the +sound of hand grenades and rounds of bullets going off on the battlefield +next to my ear was deafening; it was so intense I could not hear anything + +else. Later, there was a loud ringing in my ear that lasted for three full +days.) With a telepathy helmet, a soldier could mentally communicate +with his platoon amid all the thunder and noise." +"Recently, the army gave a $6.3 million grant to Dr. Gerwin Schalk at +Albany Medical College, but it knows that a fully functional telepathy +helmet is still years away. Dr. Schalk experiments with ECOG +technology, which, as we have seen, requires placing a mesh of +electrodes directly on top of the exposed brain. With this method, his +computers have been able to recognize vowels and thirty-six individual +words inside the thinking brain. In some of his experiments, he +approached 100 percent accuracy. But at present, this is still impractical +for the U.S. Army, since it requires removing part of the skull in the +clean, sterile environment of a hospital. And even then, recognizing +vowels and a handful of words is a far cry from sending urgent messages +to headquarters in a firefight. But his ECOG experiments have +demonstrated that it is possible to communicate mentally on the +battlefield." +"Another method is being explored by Dr. David Poeppel of New York +University. Instead of opening up the skulls of his subjects, he employs +MEG technology, using tiny bursts of magnetic energy rather than +electrodes to create electrical charges in the brain. Besides being +noninvasive, the advantage of MEG technology is that it can precisely +measure fleeting neural activity, in contrast to the slower MRI scans. In +his experiments, Poeppel has been able to successfully record electrical +activity in the auditory cortex when people think silently of a certain +word. But the drawback is that this recording still requires the use of + + large, table-size machines to generate a magnetic pulse. + +Obviously, one wants a method that is noninvasive, portable, and +accurate. Dr. Poeppel hopes his work with MEG technology will +complement the work being done using EEG sensors. But true telepathy +helmets are still many years away, because MEG and EEG scans lack +accuracy. + +MRI IN A CELL PHONE" +"MRI IN A CELL PHONE + +At present, we are hindered by the relatively crude nature of the existing + +instruments. But, as time goes by, more and more sophisticated +instruments will probe deeper into the mind. The next big breakthrough +may be MRI machines that are handheld." +"The reason why MRI machines have to be so huge right now is that +one needs a uniform magnetic field to get good resolution. The larger +the magnet, the more uniform one can make the field, and the better +accuracy one finds in the final pictures. However, physicists know the +exact mathematical properties of magnetic fields (they were worked out +by physicist James Clerk Maxwell back in the 1860S). In 1993 in +Germany, Dr. Bernhard Bliimich and his colleagues created the world’s +smallest MRI machine, which is the size of a briefcase. It uses a weak +and distorted magnetic field, but supercomputers can analyze the +magnetic field and correct for this so that the device produces realistic 3- +D pictures. Since computer power doubles roughly every two years, they +are now powerful enough to analyze the magnetic field created by the +briefcase-sized device and compensate for its distortion." +"As a demonstration of their machine, in 2006 Dr. Bliimich and his +colleagues were able to take MRI scans of Otzi, the “Iceman,” who was +frozen in ice about 5,300 years ago toward the end of the last ice age. +Because Otzi was frozen in an awkward position, with his arms spread +apart, it was difficult to cram him inside the small cylinder of a +conventional MRI machine, but Dr. Bliimich’s portable machine easily +took MRI photographs. + +These physicists estimate that, with increasing computer power, an +MRI machine of the future might be the size of a cell phone. The raw +data from this cell phone would be sent wirelessly to a supercomputer, +which would process the data from the weak magnetic field and then +create a 3-D image. (The weakness of the magnetic field is compensated +for by the increase in computer power.) This then could vastly accelerate +research. “Perhaps something like the Star Trek tricorder is not so far off" +"after all,” Dr. Bliimich has said. (The tricorder is a small, handheld +scanning device that gives an instant diagnosis of any illness.) In the +future, you may have more computer power in your medicine cabinet +than there is in a modern university hospital today. Instead of waiting to +get permission from a hospital or university to use an expensive MRI +machine, you could gather data in your own living room by simply +waving the portable MRI over yourself and then e-mailing the results to + +a lab for analysis." +"a lab for analysis. + +It could also mean that, at some point in the future, an MRI telepathy +helmet might be possible, with vastly better resolution than an EEG +scan. Here is how it may work in the coming decades. Inside the helmet, +there would be electromagnetic coils to produce a weak magnetic field +and radio pulses that probe the brain. The raw MRI signals would then +be sent to a pocketsize computer placed in your belt. The information +would then be radioed to a server located far from the battlefield. The +final processing of the data would be done by a supercomputer in a +distant city. Then the message would be radioed back to your troops on +the battlefield. The troops would hear the message either through +speakers or through electrodes placed in the auditory cortex of their +brains. + +DARPA AND HUMAN ENHANCEMENT" +"DARPA AND HUMAN ENHANCEMENT + +Given the costs of all this research, it is legitimate to ask: Who is paying +for it? Private companies have only recently shown interest in this +cutting-edge technology, but it’s still a big gamble for many of them to +fund research that may never pay off. Instead, one of the main backers is +DARPA, the Pentagon’s Defense Advanced Research Projects Agency, +which has spearheaded some of the most important technologies of the +twentieth century. + +DARPA was originally set up by President Dwight Eisenhower after +the Russians sent Sputnik into orbit in 1957 and shocked the world. +Realizing that the United States might quickly be outpaced by the +Soviets in high technology, Eisenhower hastily established this agency to +keep the country competitive with the Russians. Over the years, the +numerous projects it started grew so large that they became independent +entities by themselves. One of its first spinoffs was NASA." +"DARPA’s strategic plan reads like something from science fiction: its +“only charter is radical innovation.” The only justification for its +existence is “to accelerate the future into being.” DARPA scientists are +constantly pushing the boundaries of what is physically possible. As + + former DARPA official Michael Goldblatt says, they try not to violate the +laws of physics, “or at least not knowingly. Or at least not more than one + +per program.”" +"per program.” + +But what separates DARPA from science fiction is its track record, +which is truly astounding. One of its early projects in the 1960s was +Arpanet, which was a war-fighting telecommunications network that +would electronically connect scientists and officials during and after +World War III. In 1989, the National Science Foundation decided that, in +light of the breakup of the Soviet bloc, it was unnecessary to keep it a +secret, so it declassified this hush-hush military technology and +essentially gave codes and blueprints away for free. Arpanet would +eventually become the Internet. + +When the U.S. Air Force needed a way to guide its ballistic missiles in +space, DARPA helped create Project 57, a top-secret project that was +designed to place H-bombs on hardened Soviet missile silos in a +thermonuclear exchange. It would later become the foundation for the +Global Positioning System (GPS). Instead of guiding missiles, today it +guides lost motorists." +"DARPA has been a key player in a series of inventions that have +altered the twentieth and twenty-first centuries, including cell phones, +night-vision goggles, telecommunications advances, and weather +satellites. I have had a chance to interact with DARPA scientists and +officials on several occasions. I once had lunch with one of the agency’s +former directors at a reception filled with many scientists and futurists. I +asked him a question that had always bothered me: Why do we have to +rely on dogs to sniff our luggage for the presence of high explosives? +Surely our sensors are sensitive enough to pick up the telltale signature +of explosive chemicals. He replied that DARPA had actively looked into +this same question but had come up against some severe technical +problems. The olfactory sensors of dogs, he said, had evolved over +millions of years to be able to detect a handful of molecules, and that +kind of sensitivity is extremely difficult to match, even with our most" +"kind of sensitivity is extremely difficult to match, even with our most +finely tuned sensors. It’s likely that we will continue to rely on dogs at +airports for the foreseeable future." +"On another occasion, a group of DARPA physicists and engineers came +to a talk I gave about the future of technology. Later I asked them if they +had any concerns of their own. One concern, they said, was their public +image. Most people have never heard of DARPA, but some link it to +dark, nefarious government conspiracies, everything from UFO cover- + + ups, Area 51, and Roswell to weather control, etc. They sighed. If only +these rumors were true, they could certainly use help from alien +technology to jump-start their research!" +"With a budget of $3 billion, DARPA has now set its sights on the +brain-machine interface. When discussing the potential applications, +former DARPA official Michael Goldblatt pushes the boundary of the +imagination. He says, “Imagine if soldiers could communicate by +thought alone.... Imagine the threat of biological attack being +inconsequential. And contemplate, for a moment, a world in which +learning is as easy as eating, and the replacement of damaged body parts +as convenient as a fast-food drive-through. As impossible as these visions +sound or as difficult as you might think the task would be, these visions +are the everyday work of the Defense Sciences Office [a branch of +DARPA].”" +"Goldblatt believes that historians will conclude that the long-term +legacy of DARPA will be human enhancement, “our future historical +strength.” He notes that the famous army slogan “Be All You Can Be” +takes on a new meaning when contemplating the implications of human +enhancement. Perhaps it is no accident that Michael Goldblatt is pushing +human enhancement so vigorously at DARPA. His own daughter suffers +from cerebral palsy and has been confined to a wheelchair all her life. +Since she requires outside help, her illness has slowed her down, but she +has always risen above adversity. She is going to college and dreaming +of starting her own company. Goldblatt acknowledges that his daughter +is his inspiration. As Washington Post editor Joel Garreau has noted, +“What he is doing is spending untold millions of dollars to create what +might well be the next step in human evolution. And yet, it has occurred +to him that the technology he is helping create might someday allow his" +"to him that the technology he is helping create might someday allow his +daughter not just to walk, but to transcend.”" +"PRIVACY ISSUES + +When hearing of mind-reading machines for the first time, the average +person might be concerned about privacy. The idea that a machine +concealed somewhere may be reading our intimate thoughts without our +permission is unnerving. Human consciousness, as we have stressed, + +involves constantly running simulations of the future. In order for these +simulations to be accurate, we sometimes imagine scenarios that wade +into immoral or illegal territory, but whether or not we act on these +plans, we prefer to keep them private. + +For scientists, life would be easier if they could simply read people’s + + thoughts from a distance using portable devices (rather than by using +clumsy helmets or surgically opening up the skull), but the laws of +physics make this exceedingly difficult." +"When I asked Dr. Nishimoto, who works in Dr. Gallant’s Berkeley lab, +about the question of privacy, he smiled and replied that radio signals +degrade quite rapidly outside the brain, so these signals would be too +diffuse and weak to make any sense to anyone standing more than a few +feet away. (In school, we learned about Newton’s laws and that gravity +diminishes as the square of the distance, so that if you doubled your +distance from a star, the gravity field diminishes by a factor of four. But +magnetic fields diminish much faster than the square of the distance. +Most signals decrease by the cube or quartic of the distance, so if you +double the distance from an MRI machine, the magnetic field goes down +by a factor of eight or more.)" +"Furthermore, there would be interference from the outside world, +which would mask the faint signals coming from the brain. This is one +reason why scientists require strict laboratory conditions to do their +work, and even then they are able to extract only a few letters, words, or +images from the thinking brain at any given time. The technology is not +adequate to record the avalanche of thoughts that often circulate in our +brain as we simultaneously consider several letters, words, phrases, or +sensory information, so using these devices for mind reading as seen in +the movies is not possible today, and won’t be for decades to come." +"For the foreseeable future, brain scans will continue to require direct +access to the human brain in laboratory conditions. But in the highly +unlikely event that someone in the future finds a way to read thoughts +from a distance, there are still countermeasures you can take. To keep +your most important thoughts private, you might use a shield to block +brain waves from entering the wrong hands. This can be done with +something called a Faraday cage, invented by the great British physicist +Michael Faraday in 1836, although the effect was first observed by +Benjamin Franklin. Basically, electricity will rapidly disperse around a" +"metal cage, such that the electric field inside the cage is zero. To +demonstrate this, physicists (like myself) have entered a metallic cage on +which huge electrical bolts are fired. Miraculously, we are unscratched. +This is why airplanes can be hit by lightning bolts and not suffer +damage, and why cable wires are covered with metallic threads. +Similarly, a telepathy shield would consist of thin metal foil placed +around the brain. + +TELEPATHY VIA NANOPROBES IN THE BRAIN" +"TELEPATHY VIA NANOPROBES IN THE BRAIN + + There is another way to partially solve the privacy issue, as well as the +difficulty of placing ECOG sensors into the brain. In the future, it may be +possible to exploit nanotechnology, the ability to manipulate individual +atoms, to insert a web of nanoprobes into the brain that can tap into +your thoughts. These nanoprobes might be made of carbon nanotubes, +which conduct electricity and are as thin as the laws of atomic physics +allow. These nanotubes are made of individual carbon atoms arrayed in +a tube a few molecules thick. (They are the subject of intense scientific +interest, and are expected in the coming decades to revolutionize the +way scientists probe the brain.)" +"The nanoprobes would be placed precisely in those areas of the brain +devoted to certain activities. In order to convey speech and language, +they would be placed in the left temporal lobes. In order to process +visual images, they would be placed in the thalamus and visual cortex. +Emotions would be sent via nanoprobes in the amygdala and limbic +system. The signals from these nanoprobes would be sent to a small +computer, which would process the signals and wirelessly send +information to a server and then the Internet. + +Privacy issues would be partially solved, since you would completely +control when your thoughts are being sent over cables or the Internet. +Radio signals can be detected by any bystander with a receiver, but +electrical signals sent along a cable cannot. The problem of opening up +the skull to use messy ECOG meshes is also solved, because the +nanoprobes can be inserted via microsurgery." +"Some science-fiction writers have conjectured that when babies are +born in the future, these nanoprobes might be painlessly implanted, so + +that telepathy becomes a way of life for them. In Star Trek, for example, +implants are routinely placed into the children of the Borg at birth so +that they can telepathically communicate with others. These children +cannot imagine a world where telepathy does not exist. They take it for +granted that telepathy is the norm. + +Because these nanoprobes are tiny, they would be invisible to the +outside world, so there would be no social ostracism. Although society +might be repulsed at the idea of inserting probes permanently into the +brain, these science-fiction writers assume that people will get used to +the idea because the nanoprobes would be so useful, just like test-tube +babies have been accepted by society today after the initial controversy +surrounding them. + +LEGAL ISSUES" +"LEGAL ISSUES + + For the foreseeable future, the question is not whether someone will be +able to read our thoughts secretly from a remote, concealed device, but +whether we will willingly allow our thoughts to be recorded. What +happens, then, if some unscrupulous person gets unauthorized access to +those files? This raises the issue of ethics, since we would not want our +thoughts to be read against our will. Dr. Brian Pasley says, “There are +ethical concerns, not with the current research, but with the possible +extensions of it. There has to be a balance. If we are somehow able to +decode someone’s thoughts instantaneously that might have great +benefits for the thousands of severely disabled people who are unable to +communicate right now. On the other hand, there are great concerns if +this were applied to people who didn’t want that.”" +"Once it becomes possible to read people’s minds and make recordings, +a host of other ethical and legal questions will arise. This happens +whenever any new technology is introduced. Historically it often takes +years before the law is fully able to address their implications. + +For instance, copyright laws may have to be rewritten. What happens +if someone steals your invention by reading your thoughts? Can you +patent your thoughts? Who actually owns the idea? + +Another problem occurs if the government is involved. As John Perry +Barlow, poet and lyricist for the Grateful Dead, once said, “Relying on" +"the government to protect your privacy is like asking a peeping tom to +install your window blinds.” Would the police be allowed to read your +thoughts when you are being interrogated? Already courts have been +ruling on cases where an alleged criminal refused to submit his DNA as +evidence. In the future, will the government be allowed to read your +thoughts without your consent, and if so, will they be admissible in +court? How reliable would they be? In the same way that MRI lie +detectors measure only increased brain activity, it’s important to note +that thinking about a crime and actually committing one are two +different things. During cross-examination, a defense lawyer might argue +that these thoughts were just random musings and nothing more." +"Another gray area concerns the rights of people who are paralyzed. If +they are drafting a will or legal document, can a brain scan be sufficient +to create a legal document? Assume that a totally paralyzed person has a +sharp, active mind and wants to sign a contract or manage his funds. Are +these documents legal, given that the technology may not be perfect? + +There is no law of physics that can resolve these ethical questions. +Ultimately, as this technology matures, these issues will have to be + + settled in court by judges and juries." +"settled in court by judges and juries. + +Meanwhile, governments and corporations might have to invent new +ways to prevent mental espionage. Industrial espionage is already a +multimillion-dollar industry, with governments and corporations +building expensive “safe rooms” that have been scanned for bugs and +listening devices. In the future (assuming that a method can be devised +to listen to brain waves from a distance), safe rooms may have to be +designed so that brain signals are not accidentally leaked to the outside +world. These safe rooms would be surrounded by metallic walls, which +would form a Faraday cage shielding the interior of the room from the +outside world." +"Every time a new form of radiation has been exploited, spies have +tried to use it for espionage, and brain waves are probably no exception. +The most famous case involved a tiny microwave device hidden in the +Great Seal of the United States in the U.S. embassy in Moscow. From +1945 until 1952, it was transmitting top-secret messages from U.S. +diplomats directly to the Soviets. Even during the Berlin Crisis of 1948 +and the Korean War, the Soviets used this bug to decipher what the +United States was planning. It might have continued to leak secrets even" +"today, changing the course of the Cold War and world history, but it was +accidentally discovered when a British engineer heard secret +conversations on an open radio band. U.S. engineers were shocked when +they picked apart the bug; they failed to detect it for years because it +was passive, requiring no energy source. (The Soviets cleverly evaded +detection because the bug was energized by microwave beams from a +remote source.) It is possible that future espionage devices will be made +to intercept brain waves as well. + +Although much of this technology is still primitive, telepathy is slowly +becoming a fact of life. In the future, we may interact with the world via +the mind. But scientists want to go beyond just reading the mind, which +is passive. They want to take an active role—to move objects with the +mind. Telekinesis is a power usually ascribed to the gods. It is the divine +power to shape reality to your wishes. It is the ultimate expression of our +thoughts and desires." +"We will soon have it. + +It is the business of the future to be dangerous.... The major +advances in civilization are processes that all but wreck the +societies in which they occur. + + —ALFRED NORTH WHITEHEAD + +4 TELEKINESIS MIND CONTROLLING MATTER + +Cathy Hutchinson is trapped inside her body. + +She was paralyzed fourteen years ago by a massive stroke. A +quadriplegic, she is like thousands of “locked-in” patients who have lost +control over most of their muscles and bodily functions. Most of the day, +she lies helpless, requiring continual nursing care, yet her mind is clear. +She is a prisoner in her own body." +"But in May 2012, her fortunes changed radically. Scientists at Brown +University placed a tiny chip on top of her brain, called Braingate, which +is connected by wires to a computer. Signals from her brain are relayed +through the computer to a mechanical robotic arm. By simply thinking, +she gradually learns to control the motion of the arm so that it can, for +instance, grab a bottled drink and bring it to her mouth. For the first +time, she is able to have some control of the world around her." +"Because she is paralyzed and cannot talk, she had to communicate her +excitement by making eye movements. A device tracks her eyes and then +translates her movements into a typed message. When she was asked +how she felt, after years of being imprisoned inside a shell called her +body, she replied, “Ecstatic!” Looking forward to the day when her other +limbs are connected to her brain via computer, she added, “I would love +to have a robotic leg support.” Before her stroke, she loved to cook and +tend her garden. “I know that someday this will happen again,” she +added. At the rate at which the field of cyber prosthetics is moving, she +might have her wish soon." +"Professor John Donoghue and his colleagues at Brown University and +also at the University of Utah have created a tiny sensor that acts like a +bridge to the outside world for those who can no longer communicate. +When I interviewed him, he told me, “We have taken a tiny sensor, the +size of a baby aspirin, or four millimeters, and implanted it onto the +surface of the brain. Because of ninety-six little ‘hairs’ or electrodes that +pick up brain impulses, it can pick up signals of your intention to move + +your arm. We target the arm because of its importance.” Because the +motor cortex has been carefully mapped over the decades, it is possible +to place the chip directly on top of the neurons that control specific +limbs." +"The key to Braingate lies in translating neural signals from the chip +into meaningful commands that can move objects in the real world, +starting with the cursor of a computer screen. Donoghue told me that he +does this by asking the patient to imagine moving the cursor of a +computer screen in a certain way, e.g., moving it to the right. It takes +only a few minutes to record the brain signals corresponding to this task. +In this way, the computer recognizes that whenever it detects a brain +signal like that, it should move the cursor to the right. + +Then, whenever that person thinks of moving the cursor to the right, +the computer actually moves the cursor in that direction. In this way, +there is a one-to-one map between certain actions that the patient +imagines and the actual action itself. A patient can immediately start to +control the movement of the cursor, practically on the first try." +"Braingate opens the door to a new world of neuroprosthetics, allowing +a paralyzed person to move artificial limbs with the mind. In addition, it +lets the patient communicate directly with their loved ones. The first +version of this chip, tested in 2004, was designed so that paralyzed +patients could communicate with a laptop computer. Soon afterward, +these patients were surfing the web, reading and writing e-mails, and +controlling their wheelchairs. + +More recently, the cosmologist Stephen Hawking had a +neuroprosthetic device attached to his glasses. Like an EEG sensor, it can +connect his thoughts to a computer so that he can maintain some contact +with the outside world. It is rather primitive, but eventually devices +similar to it will become much more sophisticated, with more channels +and greater sensitivity." +"All this, Dr. Donoghue told me, could have a profound impact on the +lives of these patients: “Another useful thing is that you can connect this +computer to any device—a toaster, a coffee maker, an air conditioner, a +light switch, a typewriter. It’s really quite easy to do these things these +days, and it’s very inexpensive. For a quadriplegic who can’t get around, +they will be able to change the TV channel, turn the lights on, and do all +those things without anybody coming into the room and doing it for + +them.” Eventually, they will be able to do anything a normal person can +do, via computers. + +FIXING SPINAL CORD INJURIES + +A number of other groups are entering the fray. Another breakthrough +was made by scientists at Northwestern University who have connected" +"a monkey’s brain directly to his own arm, bypassing an injured spinal +cord. In 1995, there was the sad story of Christopher Reeve, who soared +into outer space in the Superman movies but was completely paralyzed +due to an injury to his spinal cord. Unfortunately, he was thrown off a +horse and landed on his neck, so the spinal cord was damaged just +beneath his head. If he had lived longer, he might have seen the work of +scientists who want to use computers to replace broken spinal cords. In +the United States alone, more than two hundred thousand people have +some form of spinal cord injury. In an earlier age, these individuals +might have died soon after the accident, but because of advances in +acute trauma care, the number of people who survive these sorts of +injuries has actually grown in recent years. We are also haunted by the +images of thousands of wounded warriors who were victims of roadside +bombs in Iraq and Afghanistan. And if you include the number of" +"bombs in Iraq and Afghanistan. And if you include the number of +patients paralyzed by strokes and other illnesses, like amyotropic lateral +sclerosis (ALS), the number of patients swells to two million." +"The scientists at Northwestern used a one-hundred-electrode chip, +which was placed directly on the brain of a monkey. The signals from +the brain were carefully recorded as the monkey grasped a ball, lifted it, +and released it into a tube. Since each task corresponds to a specific +firing of neurons, the scientists could gradually decode these signals. + +When the monkey wanted to move his arm, the signals were processed +by a computer using this code, and, instead of sending the messages to a +mechanical arm, they sent the signals directly to the nerves of the +monkey’s real arm. “We are eavesdropping on the natural electrical +signals from the brain that tell the arm and hand how to move, and +sending those signals directly to the muscles,” says Dr. Lee Miller. + +By trial and error, the monkey learned to coordinate the muscles in his +arm. “There is a process of motor learning that is very similar to the" +"process you go through when you learn to use a new computer, mouse, +or a different tennis racquet,” adds Dr. Miller. + +(It is remarkable that the monkey was able to master so many motions +of his arm, given the fact that there are only one hundred electrodes on +this brain chip. Dr. Miller points out that millions of neurons are +involved in controlling the arm. The reason that one hundred electrodes +can give a reasonable approximation to the output of millions of neurons +is that the chip connects to the output neurons, after all the complex +processing has already been done by the brain. With the sophisticated +analysis out of the way, the one hundred electrodes are responsible +simply for feeding that information to the arm.) + +This device is one of several being devised at Northwestern that will" +"This device is one of several being devised at Northwestern that will + + allow patients to bypass their injured spinal cords. Another neural +prosthesis uses the motion of the shoulders to control the arm. An +upward shrug causes the hand to close. A downward shrug causes the +hand to open. The patient also has the ability to curl his fingers around +an object like a cup, or manipulate a key that is grasped between the +thumb and index finger. + +Dr. Miller concludes, “This connection from brain to muscles might +someday be used to help patients paralyzed due to spinal cord injury +perform activities of daily living and achieve greater independence.” + +REVOLUTIONIZING PROSTHETICS" +"REVOLUTIONIZING PROSTHETICS + +Much of the funding driving these remarkable developments comes from +a DARPA project called Revolutionizing Prosthetics, a $150 million +effort that has been bankrolling these efforts since 2006. One of the +driving forces behind Revolutionizing Prosthetics is retired U.S. Army +colonel Geoffrey Ling, who is a neurologist with several tours of duty in +Iraq and Afghanistan. He was appalled at the human carnage he +witnessed on the battlefield caused by roadside bombs. In previous wars, +many of these brave service members would have died on the spot. But +today, with helicopters and an extensive medical evacuation +infrastructure, many of them survive but still suffer from serious bodily +injuries. More than 1,300 service members have lost limbs after coming +back from the Middle East." +"Dr. Ling asked himself whether there was a scientific way to replace +these lost limbs. Backed by funding from the Pentagon, he asked his staff +to come up with concrete solutions within five years. When he made that +request, he was met with incredulity. He recalled, “They thought we +were crazy. But it’s in insanity that things happen.” + +Spurred into action by Dr. Ling’s boundless enthusiasm, his crew has +created miracles in the laboratory. For example, Revolutionary +Prosthetics funded scientists at the Johns Hopkins Applied Physics +Laboratory who have created the most advanced mechanical arm on +Earth, which can duplicate nearly all the delicate motions of the fingers, +hand, and arm in three dimensions. It is the same size and has the same +strength and agility as a real arm. Although it is made of steel, if you +covered it up with flesh-colored plastic, it would be nearly +indistinguishable from a real arm." +"This arm was attached to Jan Sherman, a quadriplegic who had +suffered from a genetic disease that damaged the connection between +her brain and her body, leaving her completely paralyzed from the neck + + down. At the University of Pittsburgh, electrodes were placed directly on +top of her brain, which were then connected to a computer and then to a +mechanical arm. Five months after surgery to attach the arm, she +appeared on 60 Minutes. Before a national audience, she cheerfully used +her new arm to wave, greet the host, and shake his hand. She even gave +him a fist bump to show how sophisticated the arm was. + +Dr. Ling says, “In my dream, we will be able to take this into all sorts +of patients, patients with strokes, cerebral palsy, and the elderly.” + +TELEKINESIS IN YOUR LIFE" +"TELEKINESIS IN YOUR LIFE + +Not only scientists but also entrepreneurs are looking at brain-machine +interface (BMI). They wish to incorporate many of these dazzling +inventions as a permanent part of their business plans. BMI has already +penetrated the youth market, in the form of video games and toys that +use EEG sensors so that you can control objects with the mind in both +virtual reality and the real world. In 2009, NeuroSky marketed the first +toy, Mindflex, specifically designed to use EEG sensors to move a ball +through a maze. Concentrating while wearing the Mindflex EEG device + +increases the speed of a fan within the maze and propels a tiny ball +down a pathway." +"increases the speed of a fan within the maze and propels a tiny ball +down a pathway. + +Mind-controlled video games are also blossoming. Seventeen hundred +software developers are working with NeuroSky, many of them on the +company’s $129 million Mindwave Mobile headset. These video games +use a small, portable EEG sensor wrapped around your forehead that +allows you to navigate in virtual reality, where the movements of your +avatar are controlled mentally. As you maneuver your avatar on the +video screen, you can fire weapons, evade enemies, rise to new levels, +score points, etc., as in an ordinary video game, except that everything is +hands-free. + +“There’s going to be a whole ecosystem of new players, and NeuroSky +is very well positioned to be like the Intel of this new industry,” claims +Alvaro Fernandez of SharpBrains, a market research firm." +"Besides firing virtual weapons, the EEG helmet can also detect when +your attention begins to flatten out. NeuroSky has been getting inquiries +from companies concerned about injuries to workers who lose +concentration while operating a dangerous machine or who fall asleep at +the wheel. This technology could be a lifesaver, alerting the worker or +driver that he is losing his focus. The EEG helmet would set off an alarm +when the wearer dozes off. (In Japan, this headset is already creating a + + fad among partygoers. The EEG sensors look like cat ears when you put +them on your head. The ears suddenly rise when your attention is +focused and then flatten out when it fades. At parties, people can express +romantic interest just by thinking, so you know if you are impressing +someone.)" +"But perhaps the most novel applications of this technology are being +pursued by Dr. Miguel Nicolelis of Duke University. When I interviewed +him, he told me that he thinks he can duplicate many of the devices +found only in science fiction. + +SMART HANDS AND MIND MELDS + +Dr. Nicolelis has shown that this brain-machine interface can be done +across continents. He places a monkey on a treadmill. A chip is +positioned on the monkey’s brain, which is connected to the Internet. On + +the other side of the planet, in Kyoto, Japan, signals from the monkey +are used to control a robot that can walk. By walking on the treadmill in +North Carolina, the monkey controls a robot in Japan, which executes +the same walking motion. Using only his brain sensors and the reward of +a food pellet, Dr. Nicolelis has trained these monkeys to control a +humanoid robot called CB-1 halfway around the world." +"He is also tackling one of the main problems with brain-machine +interface: the lack of feeling. Today’s prosthetic hands don’t have a sense +of touch, and hence they feel foreign; because there’s no feedback, they +might accidentally crush someone’s fingers while engaging in a +handshake. Picking up an eggshell with a mechanical arm would be +nearly impossible. + +Nicolelis hopes to circumvent this problem by having a direct brain-to- +brain interface. Messages would be sent from the brain to a mechanical +arm that has sensors, which would then send messages directly back to +the brain, thereby bypassing the stem altogether. This brain-machine- +brain interface (BMBI) could enable a clean, direct feedback mechanism +to allow for the sensation of touch." +"Dr. Nicolelis started by connecting the motor cortex of rhesus monkeys +to mechanical arms. These mechanical arms have sensors on them, +which then send signals back to the brain by electrodes connected to the +somatosensory cortex (which registers the sensation of touch). The +monkeys were given a reward after every successful trial; they learned +how to use this apparatus within four to nine trials. + + To do this, Dr. Nicolelis had to invent a new code that would +represent different surfaces (which were rough or smooth). “After a +month of practice,” he told me, “this part of the brain learns this new +code, and starts to associate this new artificial code that we created with +different textures. So this is the first demonstration that we can create a +sensory channel” that can simulate sensations of the skin." +"I mentioned to him that this idea sounds like the “holodeck” of Star +Trek, where you wander in a virtual world but feel sensations when you +bump into virtual objects, just as if they were real. This is called “haptic +technology,” which uses digital technology to simulate the sense of +touch. Nicolelis replied, “Yes, I think this is the first demonstration that +something like the holodeck will be possible in the near future.” + +The holodeck of the future might use a combination of two + +technologies. First, people in the holodeck would wear Internet contact +lenses, so that they would see an entirely new virtual world everywhere +they looked. The scenery in your contact lens would change instantly +with the push of a button. And if you touched any object in this world, +signals sent into the brain would simulate the sensation of touch, using +BMBI technology. In this way, objects in the virtual world you see inside +your contact lens would feel solid." +"Brain-to-brain interface would make possible not only haptic +technology, but also an “Internet of the mind,” or brain-net, with direct +brain-to-brain contact. In 2013, Dr. Nicolelis was able to accomplish +something straight out of Star Trek, a “mind meld” between two brains. +He started with two groups of rats, one at Duke University, the other in +Natal, Brazil. The first group learned to press a lever when seeing a red +light. The second group learned to press a lever when their brains were +stimulated by a signal sent via an implant. Their reward for pressing the +lever was a sip of water. Then Dr. Nicolelis connected the motor cortices +of the brains of both groups via a fine wire through the Internet." +"When the first group of rats saw the red light, a signal was sent over +the Internet to Brazil to the second group, which then pressed the lever. +In seven out of ten trials, the second group of rats correctly responded to +the signals sent by the first group. This was the first demonstration that +signals could be transferred and also interpreted correctly between two +brains. It’s still a far cry from the mind meld of science fiction, where +two minds merge into one, because this is still primitive and the sample +size is small, but it is a proof of principle that a brain-net might be +possible. + +In 2013, the next important step was taken when scientists went +beyond animal studies and demonstrated the first direct human brain-to- + + brain communication, with one human brain sending a message to +another via the Internet." +"brain communication, with one human brain sending a message to +another via the Internet. + +This milestone was achieved at the University of Washington, with +one scientist sending a brain signal (move your right arm) to another +scientist. The first scientist wore an EEG helmet and played a video +game. He fired a cannon by imagining moving his right arm, but was +careful not to move it physically. + +The signal from the EEG helmet was sent over the Internet to another +scientist, who was wearing a transcranial magnetic helmet carefully + +placed over the part of his brain that controlled his right arm. When the +signal reached the second scientist, the helmet would send a magnetic +pulse into his brain, which made his right arm move involuntarily, all by +itself. Thus, by remote control, one human brain could control the +movement of another." +"This breakthrough opens up a number of possibilities, such as +exchanging nonverbal messages via the Internet. You might one day be +able to send the experience of dancing the tango, bungee jumping, or +skydiving to the people on your e-mail list. Not just physical activity, but +emotions and feelings as well might be sent via brain-to-brain +communication." +"Nicolelis envisions a day when people all over the world could +participate in social networks not via keyboards, but directly through +their minds. Instead of just sending e-mails, people on the brain-net +would be able to telepathically exchange thoughts, emotions, and ideas +in real time. Today a phone call conveys only the information of the +conversation and the tone of voice, nothing more. Video conferencing is +a bit better, since you can read the body language of the person on the +other end. But a brain-net would be the ultimate in communications, +making it possible to share the totality of mental information in a +conversation, including emotions, nuances, and reservations. Minds +would be able to share their most intimate thoughts and feelings. + +TOTAL IMMERSION ENTERTAINMENT" +"TOTAL IMMERSION ENTERTAINMENT + +Developing a brain-net may also have an impact on the multibillion- +dollar entertainment industry. Back in the 1920s, the technology of tape¬ +recording sound as well as light was perfected. This set off a +transformation in the entertainment industry as it made the transition +from silent movies to the “talkies.” This basic formula of combining +sound and sight hasn’t changed much for the past century. But in the + + future, the entertainment industry may make the next transition, +recording all five senses, including smell, taste, and touch, as well as the +full range of emotions. Telepathic probes would be able to handle the +full range of senses and emotions that circulate in the brain, producing a +complete immersion of the audience in the story. Watching a romantic" +"movie or an action thriller, we would be swimming in an ocean of +sensations, as if we were really there, experiencing all the rush of +feelings and the emotions of the actors. We would smell the perfume of +the heroine, feel the terror of the victims in a horror movie, and relish +the vanquishing of the bad guys." +"This immersion would involve a radical shift in how movies are made. +First, actors would have to be trained to act out their roles with +EEG/MRI sensors and nanoprobes recording their sensations and +emotions. (This would place an added burden on the actors, who would +have to act out each scene by simulating all five senses. In the same way +that some actors could not make the transition from silent movies to the +talkies, perhaps a new generation of actors will emerge who can act out +scenes with all five senses.) Editing would require not just cutting and +splicing film, but also combining tapes of the various sensations within +each scene. And finally the audience, as they sit in their seats, would +have all these electrical signals fed into their brains. Instead of 3-D +glasses, the audience would wear brain sensors of some sort. Movie +theaters would also have to be retrofitted to process this data and then +send it to the people in the audience. + +CREATING A BRAIN-NET" +"CREATING A BRAIN-NET + +Creating a brain-net that can transmit such information would have to +be done in stages. The first step would be inserting nanoprobes into +important parts of the brain, such as the left temporal lobe, which +governs speech, and the occipital lobe, which governs vision. Then +computers would analyze these signals and decode them. This +information in turn could be sent over the Internet by fiber-optic cables. + +More difficult would be to insert these signals back into another +person’s brain, where they could be processed by the receiver. So far, +progress in this area has focused only on the hippocampus, but in the +future it should be possible to insert messages directly into other parts of +the brain corresponding to our sense of hearing, light, touch, etc. So +there is plenty of work to be done as scientists try to map the cortices of +the brain involved in these senses. Once these cortices have been +mapped—such as the hippocampus, which we’ll discuss in the next" +"chapter—it should be possible to insert words, thoughts, memories, and +experiences into another brain. + +Dr. Nicolelis writes, “It is not inconceivable that our human progeny +may indeed muster the skills, technology, and ethics needed to establish +a functional brain-net, a medium through which billions of human +beings consensually establish temporary direct contacts with fellow +human beings through thought alone. What such a colossus of collective +consciousness may look like, feel like, or do, neither I nor anyone in our +present time can possibly conceive or utter.” + +THE BRAIN-NET AND CIVILIZATION" +"A brain-net may even change the course of civilization itself. Each time a +new communication system has been introduced, it has irrevocably +accelerated changes in society, lifting us from one era to the next. In +prehistoric times, for thousands of years our ancestors were nomads +wandering in small tribes, communicating with one another through +body language and grunts. The coming of language allowed us for the +first time to communicate symbols and complex ideas, which facilitated +the rise of villages and eventually cities. Within the last few thousand +years, written language has enabled us to accumulate knowledge and +culture across generations, allowing for the rise of science, the arts, +architecture, and huge empires. The coming of the telephone, radio, and +TV extended the reach of communication across continents. The Internet +now makes possible the rise of a planetary civilization that will link all +the continents and peoples of the world. The next giant step might be a" +"the continents and peoples of the world. The next giant step might be a +planetary brain-net, in which the full spectrum of senses, emotions, +memories, and thoughts are exchanged on a global scale." +"‘WE WILL BE PART OF THEIR OPERATING SYSTEM' + +When I interviewed Dr. Nicolelis, he told me that he became interested +in science at an early age while growing up in his native Brazil. He +remembers watching the Apollo moon shot, which captured the world’s +attention. To him, it was an amazing feat. And now, he told me, his own +“moon shot” is making it possible to move any object with the mind. + +He became interested in the brain while still in high school, where he +came across a 1964 book by Isaac Asimov titled The Human Brain. But he +was disappointed by the end of the book. There was no discussion about +how all these structures interacted with one another to create the mind + + (because no one knew the answer back then). It was a life-changing +moment and he realized that his own destiny might lie in trying to +understand the secrets of the brain." +"About ten years ago, he told me, he began to look seriously into doing +research on his childhood dream. He started by taking a mouse and +letting it control a mechanical device. “We placed sensors into the mouse +which read the electrical signals from the brain. Then we transmitted +these signals to a little robotic lever that could bring water from a +fountain back to the mouse’s mouth. So the animal had to learn how to +mentally move the robotic device to bring the water back. That was the +first-ever demonstration that you could connect an animal to a machine +so that it could operate a machine without moving its own body,” he +explained to me." +"Today he can analyze not just fifty but one thousand neurons in the +brain of a monkey, which can reproduce various movements in different +parts of the monkey’s body. Then the monkey can control various +devices, such as mechanical arms, or even virtual images in cyberspace. +“We even have a monkey avatar that can be controlled by the monkey’s +thoughts without the monkey making any movement,” he told me. This +is done by having the monkey watch a video in which he sees an avatar +that represents his body. Then, by mentally commanding his body to +move, the monkey makes the avatar move in the corresponding way. + +Nicolelis envisions a day in the very near future when we will play +video games and control computers and appliances with our minds. “We + +will be part of their operating system. We will be immersed in them with +mechanisms that are very similar to the experiments that I am +describing.” + +EXOSKELETONS" +"EXOSKELETONS + +The next undertaking for Dr. Nicolelis is the Walk Again Project. Its goal +is nothing less than a complete exoskeleton for the body controlled by +the mind. At first, an exoskeleton conjures up an image of something +from the Iron Man movies. Actually, it is a special suit that encases the +entire body so that the arms and legs can move via motors. He calls it a +“wearable robot.” (See Figure 10.) + +His goal, he said, is to help the paralyzed “walk by thinking.” He plans +to use wireless technology, “so there’s nothing sticking out of the head. +... We are going to record twenty to thirty thousand neurons, to +command a whole body robotic vest, so he can think and walk again and + + move and grab objects.”" +"move and grab objects.” + +Nicolelis realizes that a series of hurdles must be overcome before the +exoskeleton becomes a reality. First, a new generation of microchips +must be created that can be placed in the brain safely and reliably for +years at a time. Second, wireless sensors must be created so the +exoskeleton can roam freely. The signals from the brain would be +received wirelessly by a computer the size of a cell phone that would +probably be attached to your belt. Third, new advances must be made in +deciphering and interpreting signals from the brain via computers. For +the monkeys, a few hundred neurons were necessary to control the +mechanical arms. For a human, you need, at minimum, several thousand +neurons to control an arm or leg. And fourth, a power supply must be +found that is portable and powerful enough to energize the entire +exoskeleton. + +Figure 10. This is the exoskeleton that Dr. Nicolelis hopes will be controlled by the mind of a totally +paralyzed person." +"(illustration credit 4.1) + +Nicolelis’s goal is a lofty one: to have a working exoskeleton suit ready +for the 2014 World Cup in Brazil, where a quadriplegic Brazilian will +deliver the opening kick. He told me proudly, “This is our Brazilian +moon shot.” + +AVATARS AND SURROGATES + +In the movie Surrogates, Bruce Willis plays an FBI agent who is +investigating mysterious murders. Scientists have created exoskeletons so +perfect that they exceed human capabilities. These mechanical creatures +are super strong, with perfect bodies. In fact, they are so perfect that +humanity has become dependent on them. People live their entire life in +pods, mentally controlling their handsome, beautiful surrogate with" +"wireless technology. Everywhere you go, you see busy “people” at work, +except they are all perfectly shaped surrogates. Their aging masters are +conveniently hidden from view. The plot takes a sharp twist, however, +when Bruce Willis discovers that the person behind these murders might +be linked to the same scientist who invented these surrogates in the first +place. That forces him to wonder whether the surrogates are a blessing +or a curse." +"And in the blockbuster movie Avatar, in the year 2154 Earth has +depleted most of its minerals, so a mining company has journeyed to a +distant moon called Pandora in the Alpha Centauri star system in search +of a rare metal, unobtanium. There are native people who inhabit this +distant moon, called the Na’vi, who live in harmony with their lush +environment. In order to communicate with the native people, specially +trained workers are placed in pods, where they learn to mentally control +the body of a genetically engineered native. Although the atmosphere is +poisonous and the environment differs radically from Earth’s, avatars +have no difficulty living in this alien world. This uneasy relationship, +however, soon collapses when the mining company finds a rich deposit +of unobtainium underneath the Na’vi’s sacred ceremonial tree. Inevitably +a conflict arises between the mining company, which wants to destroy +the sacred tree and strip-mine the land for its rare metal, and the" +"the sacred tree and strip-mine the land for its rare metal, and the +natives, who worship it. It looks like a lost cause for the natives until one +of the specially trained workers switches sides and leads the Na’vi to +victory." +"Avatars and surrogates are the stuff of science fiction today, but one +day they may become an essential tool for science. The human body is +frail, perhaps too delicate for the rigors of many dangerous missions, +including space travel. Although science fiction is filled with the heroic +exploits of brave astronauts traveling to the farthest reaches of our +galaxy, the reality is much different. Radiation in deep space is so +intense that our astronauts will have to be shielded or else face +premature aging, radiation sickness, and even cancer. Solar flares shot +from the sun can bathe a spacecraft in lethal radiation. A simple +transatlantic flight from the United States to Europe exposes you to a +millirem of radiation per hour, or roughly the same as a dental X-ray. +But in outer space, the radiation could be many times more intense, +especially in the presence of cosmic rays and solar bursts. (During" +"intense solar storms, NASA has actually warned astronauts in the space +station to move to sections where there is more shielding against +radiation.) + +In addition, there are many other dangers awaiting us in outer space, +such as micrometeorites, the effects of prolonged weightlessness, and the +problems of adjusting to different gravity fields. After just a few months +in weightlessness, the body loses a large fraction of its calcium and +minerals, leaving the astronauts incredibly weak, even if they exercise +every day. After a year in outer space, Russian astronauts had to crawl +out of their space capsules like worms. Furthermore, it is believed that +some of the effects of muscle and bone loss are permanent, so that +astronauts will feel the consequences of prolonged weightlessness for the +rest of their lives." +"The dangers of micrometeorites and intense radiation fields on the +moon are so great that many scientists have proposed using a gigantic +underground cave as a permanent lunar space station to protect our +astronauts. These caves form naturally as lava tubes near extinct +volcanoes. But the safest way of building a moon base is to have our +astronauts sit in the comfort of their living rooms. This way they would +be shielded from all the hazards found on the moon, yet through +surrogates they would be able to perform the same tasks. This could +vastly reduce the cost of manned space travel, since providing life +support for human astronauts is very expensive. + +Perhaps when the first interplanetary ship reaches a distant planet, +and an astronaut’s surrogate sets foot on this alien terrain, he or she +might start with “One small step for the mind ...”" +"One possible problem with this approach is that it takes time for +messages to go to the moon and beyond. In a little over a second, a radio +message can travel from Earth to the moon, so surrogates on the moon +could be easily controlled by astronauts on Earth. More difficult would +be communicating with surrogates on Mars, since it can take twenty +minutes or more for radio signals to reach the Red Planet. + +But surrogates have practical implications closer to home. In Japan, +the Fukushima reactor accident in 2011 caused billions of dollars in +damages. Because workers can’t enter areas with lethal levels of +radiation for more than a few minutes, the final cleanup may take up to +forty years. Unfortunately, robots are not sufficiently advanced to go" +"into these blistering radiation fields and make needed repairs. In fact, +the only robots used at Fukushima are quite primitive, basically simple +cameras placed on top of a computer sitting on wheels. A full-blown +automaton that can think for itself (or be controlled by a remote +operator) and make repairs in high-radiation fields is many decades +away." +"The lack of industrial robots caused an acute problem for the Soviets +as well during the 1986 Chernobyl accident in the Ukraine. Workers sent +directly to the accident site to put out the flames died horrible deaths +due to lethal exposure to radiation. Eventually Mikhail Gorbachev +ordered the air force to “sand bag” the reactor, dropping five thousand +tons of borated sand and cement by helicopter. Radiation levels were so +high that 250,000 workers were recruited to finally contain the accident. +Each worker could spend only a few minutes inside the reactor building +doing repairs. Many received the maximum lifetime allowed dose of +radiation. Each one got a medal. This massive project was the largest +civil engineering feat ever undertaken. It could not have been done by +today’s robots." +"The Honda Corporation has, in fact, built a robot that may eventually +go into deadly radioactive environments, but it is not ready yet. Honda’s +scientists have placed an EEG sensor on the head of a worker, which is +connected to a computer that analyzes his brain waves. The computer is +then connected to a radio that sends messages to the robot, called +ASIMO (Advanced Step in Innovative Mobility). Hence, by altering his +own brain waves, a worker can control ASIMO by pure thought. + +Unfortunately, this robot is incapable of making repairs at Fukushima +right now, since it can execute only four basic motions (all of which +involve moving its head and shoulders) while hundreds of motions are +required to make repairs at a shattered nuclear power plant. This system +is not developed enough to handle simple tasks such as turning a +screwdriver or swinging a hammer." +"Other groups have also explored the possibility of mentally controlled +robots. At the University of Washington, Dr. Rajesh Rao has created a +similar robot that is controlled by a person wearing an EEG helmet. This +shiny humanoid robot is two feet tall and is called Morpheus (after a +character in the movie The Matrix, as well as the Greek god of dreams). +A student puts on the EEG helmet and then makes certain gestures, such" +"as moving a hand, which creates an EEG signal that is recorded by a +computer. Eventually the computer has a library of such EEG signals, +each one corresponding to a specific motion of a limb. Then the robot is +programmed to move its hand whenever that EEG signal is sent to it. In +this way, if you think about moving your hand, the robot Morpheus +moves its hand as well. When you put on the EEG helmet for the first +time, it takes about ten minutes for the computer to calibrate to your +brain signals. Eventually you get the hang of making gestures with your +mind that control the robot. For example, you can have it walk toward +you, pick up a block from a table, walk six feet to another table, and +then place the block there." +"Research is also progressing rapidly in Europe. In 2012, scientists in +Switzerland at the Ecole Poly technique Federate de Lausanne unveiled +their latest achievement, a robot controlled telepathically by EEG sensors +whose controller is located sixty miles away. The robot itself looks like +the Roomba robotic vacuum cleaner now found in many living rooms. +But it is actually a highly sophisticated robot equipped with a camera +that can navigate its way through a crowded office. A paralyzed patient +can, for example, look at a computer screen, which is connected to a +video camera on the robot many miles away, and see through the eyes of +the robot. Then, by thinking, the patient is able to control the motion of +the robot as it moves past obstacles." +"In the future, one can imagine the most dangerous jobs being done by +robots controlled by humans in this fashion. Dr. Nicolelis says, “We will +likely be able to operate remotely controlled envoys and ambassadors, +robots and airships of many shapes and sizes, sent on our behalf to +explore other planets and stars in distant corners of the universe.” + +For example, in 2010 the world looked on in horror as 5 million +barrels of crude oil spilled unabated into the Gulf of Mexico. The +Deepwater Horizon spill was one of the largest oil disasters in history, +yet engineers were largely helpless for three months. Robotic subs, +which are controlled remotely, floundered for weeks trying to cap the +well because they lacked the dexterity and versatility necessary for this +underwater mission. If surrogate subs, which are much more sensitive in +manipulating tools, had been available, they might have capped the well +in the first few days of the spill, preventing billions in property damage +and lawsuits." +"Another possibility is that surrogate submarines might one day enter +the human body and perform delicate surgery from the inside. This idea +was explored in the movie Fantastic Voyage, starring Raquel Welch, in +which a submarine was shrunk down to the size of a blood cell and then +injected into the bloodstream of someone who had a blood clot in his +brain. Shrinking atoms violates the laws of quantum physics, but one +day MEMS (micro-electrical-mechanical systems) the size of cells might +be able to enter a person’s bloodstream. MEMS are incredibly small +machines that can easily fit on a pinpoint. MEMS employ the same +etching technology used in Silicon Valley, which can put hundreds of +millions of transistors on a wafer the size of your fingernail. An +elaborate machine with gears, levers, pulleys, and even motors can be +made smaller than the period at the end of this sentence. One day a +person may be able to put on a telepathy helmet and then command a" +"person may be able to put on a telepathy helmet and then command a +MEMS submarine using wireless technology to perform surgery inside a +patient." +"So MEMS technology may open up an entirely new field of medicine, +based on microscopic machines entering the body. These MEMS +submarines might even guide nanoprobes as they enter the brain so that +they connect precisely to the neurons that are of interest. In this way, +nanoprobes might be able to receive and transmit signals from the +handful of neurons that are involved in specific behaviors. The hit-or- +miss approach of inserting electrodes into the brain will be eliminated. + +THE FUTURE + +In the short term, all these remarkable advances taking place in + + laboratories around the world may alleviate the suffering of those +afflicted by paralysis and other disabilities. Using the power of their +minds, they will be able to communicate with loved ones, control their +wheelchairs and beds, walk by mentally guiding mechanical limbs, +manipulate household appliances, and lead seminormal lives." +"But in the long term, these advances could have profound economic +and practical implications for the world. By mid-century, it could +become commonplace to interact with computers directly with the mind. +Since the computer business is a multitrillion-dollar industry that can + +create young billionaires and corporations almost overnight, advances in +the mind-computer interface will reverberate on Wall Street—and also in +your living room. + +All the devices we use to communicate with computers (the mouse, +keyboards, etc.) may eventually disappear. In the future, we may simply +give mental commands and our wishes will be silently carried out by +tiny chips hidden in the environment. While sitting in our offices, taking +a stroll in the park, doing window-shopping, or just relaxing, our minds +could be interacting with scores of hidden chips, allowing us to mentally +balance our finances, arrange for theater tickets, or make a reservation." +"Artists may also make good use of this technology. If they can +visualize their artwork in their minds, then the image can be displayed +via EEG sensors on a holographic screen in 3-D. Since the image in the +mind is not as precise as the original object, the artist could then make +improvements on the 3-D image and dream up the next iteration. After +several cycles, the artist could print out the final image on a 3-D printer. + +Similarly, engineers would be able to create scale models of bridges, +tunnels, and airports by simply using their imagination. They could also +rapidly make changes in their blueprints through thought alone. +Machine parts could fly off the computer screen and into a 3-D printer." +"Some critics, however, have claimed that these telekinetic powers +have one great limitation: the lack of energy. In the movies, super beings +have the power to move mountains using their thoughts. In the movie X- +Men: The Last Stand, the super villain Magneto had the ability to move +the Golden Gate Bridge simply by pointing his fingers, but the human +body can muster only about one-fifth of a horsepower on average, which +is much too little power to perform the feats we see in the comic books. +Therefore, all the herculean feats of telekinetic super beings appear to be +pure fantasy. + +There is one solution to this energy problem, however. You may be +able to connect your thoughts to a power source, which would then" +"magnify your power millions of times. In this way, you could +approximate the power of a god. In one episode of Star Trek, the crew +journeys to a distant planet and meets a godlike creature who claims to +be Apollo, the Greek god of the sun. He can perform feats of magic that +dazzle the crew. He even claims to have visited Earth eons ago, where +the earthlings worshipped him. But the crew, not believing in gods, + +suspect a fraud. Later they figure out that this “god” just mentally +controls a hidden power source, which then performs all the magic +tricks. When this power source is destroyed, he becomes a mere mortal." +"Similarly, in the future our minds may mentally control a power +source that will then give us superpowers. For example, a construction +worker might telepathically exploit a power source that energizes heavy +machinery. Then a single worker might be able to build complex +buildings and houses just by using the power of his mind. All the heavy +lifting would be done by the power source, and the construction worker +would resemble a conductor, able to orchestrate the motion of colossal +cranes and powerful bulldozers through thought alone. + +Science is beginning to catch up to science fiction in yet another way. +The Star Wars saga was supposed to take place in a time when +civilizations span the entire galaxy. The peace of the galaxy, in turn, is +maintained by the Jedi Knights, a highly trained cadre of warriors who +use the power of the “Force” to read minds and guide their lightsabers." +"However, one need not wait until we have colonized the entire galaxy +to begin contemplating the Force. As we’ve seen, some aspects of the +Force are possible today, such as being able to tap into the thoughts of +others using ECOG electrodes or EEG helmets. But the telekinetic powers +of the Jedi Knights will also become a possibility as we learn to harness +a power source with our minds. The Jedi Knights, for example, can +summon a light-saber simply by waving their hands, but we can already +accomplish the same feat by exploiting the power of magnetism (much +as the magnet in an MRI machine can hurl a hammer across a room). By +mentally activating the power source, you can grab lightsabers from +across the room with today’s technology. + +THE POWER OF A GOD" +"THE POWER OF A GOD + +Telekinesis is a power usually reserved for a deity or a superhero. In the +universe of superheros appearing in blockbuster Hollywood movies, +perhaps the most powerful character is Phoenix, a telekinetic woman +who can move any object at will. As a member of the X-Men, she can lift +heavy machinery, hold back floods, or raise jet airplanes via the power + + of her mind. (However, when she is finally consumed by the dark side of + +her power, she goes on a cosmic rampage, capable of incinerating entire +solar systems and destroying stars. Her power is so great and +uncontrollable that it leads to her eventual self-destruction.) + +But how far can science go in harnessing telekinetic powers?" +"But how far can science go in harnessing telekinetic powers? + +In the future, even with an external power source to magnify our +thoughts, it is unlikely that people with telekinetic powers will be able +to move basic objects like a pencil or mug of coffee on command. As we +mentioned, there are only four known forces that rule the universe, and +none of them can move objects unless there is an external power source. +(Magnetism comes close, but magnetism can move only magnetic +objects. Objects made of plastic, water, or wood can easily pass through +magnetic fields.) Simple levitation, a trick found in most magicians’ +shows, is beyond our scientific capability. + +So even with an external power supply, is it unlikely that a telekinetic +person would be able to move the objects around them at will. However, +there is a technology that may come close, and that involves the ability +to change one object into another." +"The technology is called “programmable matter,” and it has become a +subject of intense research for the Intel Corporation. The idea behind +programmable matter is to create objects made of tiny “catoms,” which +are microscopic computer chips. Each catom can be controlled +wirelessly; it can be programmed to change the electrical charge on its +surface so it can bind with other catoms in different ways. By +programming the electric charges one way, the catoms bind together to +form, say, a cell phone. Push a button to change their programming, and +the catoms rearrange themselves to re-form into another object, like a +laptop." +"I saw a demonstration of this technology at Carnegie Mellon +University in Pittsburgh, where scientists have been able to create a chip +the size of a pinpoint. To exam these catoms, I had to enter a “clean +room” wearing a special white uniform, plastic boots, and a cap to +prevent even the smallest dust particle from entering. Then, under a +microscope, I could see the intricate circuitry inside each catom, which +makes it possible to program it wirelessly to change the electrical charge +on its surface. In the same way we can program software today, in the +future it may be possible to program hardware. + +The next step is to determine if these catoms can combine to form" +"The next step is to determine if these catoms can combine to form + + useful objects, and to see if they can be changed or morphed into +another object at will. It may take until mid-century before we have +working prototypes of programmable matter. Because of the complexity +of programming billions of catoms, a special computer would have to be +created to orchestrate the charge on each catom. Perhaps by the end of +this century, it will be possible to mentally control this computer so that +we can change one object into another. We would not have to memorize +the charges and configuration within an object. We would just give the +mental command to the computer to change one object into another." +"Eventually we might have catalogs listing all the various objects that +are programmable, such as furniture, appliances, and electronics. Then +by telepathically communicating with the computer, it should be +possible to change one object into another. Redecorating your living +room, remodeling your kitchen, and buying Christmas presents could all +be done mentally. + +A MORALITY TALE + +Having every wish come true is something that only a divinity can +accomplish. However, there is also a downside to this celestial power. +All technologies can be used for good or for evil. Ultimately, science is a +double-edged sword. One side of the sword can cut against poverty, +disease, and ignorance. But the other side can cut against people, in +several ways." +"These technologies could conceivably make wars even more vicious. +Perhaps one day, all hand-to-hand combat will be between two +surrogates, armed with a battery of high-tech weapons. The actual +warriors, sitting safely thousands of miles away, would unleash a +barrage of the latest high-tech weaponry with little regard for the +collateral damage they are inflicting on civilians. Although wars fought +with surrogates may preserve the lives of the soldiers themselves, they +might also cause horrendous civilian and property damage. + +The bigger problem is that this power may also be too great for any +common mortal to control. In the novel Carrie, Stephen King explored +the world of a young girl who was constantly taunted by her peers. She +was ostracized by the in-crowd and her life became a never-ending series + +of insults and humiliations. However, her tormentors did not know one +thing about her: she was telekinetic. + +After enduring the taunts and having blood splashed all over her dress" +"After enduring the taunts and having blood splashed all over her dress + + at the prom, she finally cracks. She summons all her telekinetic power to +trap her classmates and then annihilate them one by one. In a final +gesture, she decides to burn the entire school down. But her telekinetic +power was too great to control. She ultimately perishes in the fire that +she started. + +Not only can the awesome power of telekinesis backfire, but there is +another problem as well. Even if you have taken all the precautions to +understand and harness this power, it could still destroy you if, +ironically enough, it is too obedient to your thoughts and commands. +Then the very thoughts you conceive may spell your doom." +"The movie Forbidden Planet (1956) is based on a play by William +Shakespeare, The Tempest, which begins with a sorcerer and his daughter +stranded on a deserted island. But in Forbidden Planet, a professor and his +daughter are stranded on a distant planet that was once the home of the +Krell, a civilization millions of years more advanced than ours. Their +greatest achievement was to create a device that gave them the ultimate +power of telekinesis, the power to control matter in all its forms by the +mind. Anything they desired suddenly materialized before them. This +was the power to reshape reality itself to their whims. + +Yet on the eve of their greatest triumph, as they were turning on this +device the Krell disappeared without a trace. What could have possibly +destroyed this most advanced civilization?" +"When a crew of earthmen land on the planet to rescue the man and +his daughter, they find that there is a hideous monster haunting the +planet, slaughtering crew members at will. Finally, one crew member +discovers the secret behind both the Krell and the monster. Before he +dies, he gasps, “Monsters from the id.” + +Then the shocking truth suddenly dawns on the professor. The very +night that the Krell turned on their telekinesis machine, they fell asleep. +All the repressed desires from their ids then suddenly materialized. +Buried in the subconscious of these highly developed creatures were the +long-suppressed animal urges and desires of their ancient past. Every +fantasy, every dream of revenge suddenly came true, so this great +civilization destroyed itself overnight. They had conquered many worlds, + +but there was one thing they could not control: their own subconscious +minds." +"but there was one thing they could not control: their own subconscious +minds. + +That is a lesson for anyone who desires to unleash the power of the +mind. Within the mind, you find the noblest achievements and thoughts +of humanity. But you will also find monsters from the id. + + CHANGING WHO WE ARE: OUR MEMORIES AND INTELLIGENCE + +So far, we have discussed the power of science to extend our mental +abilities via telepathy and telekinesis. We basically remain the same; +these developments do nothing to change the essence of who we are. +However, there is an entirely new frontier opening up that alters the +very nature of what it means to be human. Using the very latest in +genetics, electromagnetics, and drug therapy, it may become possible in +the near future to alter our memories and even enhance our intelligence. +The idea of downloading a memory, learning complex skills overnight, +and becoming super intelligent is slowly leaving the realm of science +fiction." +"Without our memories, we are lost, cast adrift in an aimless sea of +pointless stimuli, unable to understand the past or ourselves. So what +happens if one day we can input artificial memories into our brains? +What happens when we can become a master of any discipline simply by +downloading the file into our memory? And what happens if we cannot +tell the difference between real and fake memories? Then who are we? + +Scientists are moving past being passive observers of nature to actively +shaping and molding nature. This means that we might be able to +manipulate memories, thoughts, intelligence, and consciousness. Instead +of simply witnessing the intricate mechanics of the mind, in the future it +will be possible to orchestrate them. + +So let us now answer this question: Can we download memories? + +If our brains were simple enough to be understood, we +wouldn’t be smart enough to understand them. + +—ANONYMOUS + +5 MEMORIES AND THOUGHTS MADE TO ORDER" +"—ANONYMOUS + +5 MEMORIES AND THOUGHTS MADE TO ORDER + +Neo is The One. Only he can lead a defeated humanity to victory +against the Machines. Only Neo can destroy the Matrix, which has +implanted false memories into our brains as a means to control us. + +In a now-classic scene from the film The Matrix, the evil Sentinels, +who guard the Matrix, have finally cornered Neo. It looks like +humanity’s last hope is about to be terminated. But previously Neo had + + had an electrode jacked into the back of his neck that could instantly +download martial-arts skills into his brain. In seconds, he becomes a +karate master able to take down the Sentinels with breathtaking aerial +kicks and well-placed strikes. + +In The Matrix, learning the amazing skills of a black-belt karate master +is no harder than slipping an electrode into your brain and pushing the +“download” button. Perhaps one day we, too, may be able to download +memories, which will vastly increase our abilities." +"But what happens when the memories downloaded into your brain are +false? In the movie Total Recall, Arnold Schwarzenegger has fake +memories placed into his brain, so that the distinction between reality +and fiction becomes totally blurred. He valiantly fights off the bad guys +on Mars until the end of the movie, when he suddenly realizes that he +himself is their leader. He is shocked to find that his memories of being a +normal, law-abiding citizen are totally manufactured. + +Hollywood is fond of movies that explore the fascinating but fictional +world of artificial memories. All this is impossible, of course, with +today’s technology, but one can envision a day, a few decades from now, +when artificial memories may indeed be inserted into the brain. + +HOW WE REMEMBER + +Like Phineas Gage’s, the strange case of Henry Gustav Molaison, known +in the scientific literature as simply HM, created a sensation in the field" +"of neurology that led to many fundamental breakthroughs in +understanding the importance of the hippocampus in formulating +memories." +"At the age of nine, HM suffered head injuries in an accident that +caused debilitating convulsions. In 1953, when he was twenty-five years +old, he underwent an operation that successfully relieved his symptoms. +But another problem surfaced because surgeons mistakenly cut out part +of his hippocampus. At first, HM appeared normal, but it soon became +apparent that something was terribly wrong; he could not retain new +memories. Instead, he constantly lived in the present, greeting the same +people several times a day with the same expressions, as if he were +seeing them for the first time. Everything that went into his memory +lasted only a few minutes before it disappeared. Like Bill Murray in the +movie Groundhog Day, HM was doomed to relive the same day, over and +over, for the rest of his life. But unlike Bill Murray’s character, he was +unable to recall the previous iterations. His long-term memory, however," +"was relatively intact and could remember his life before the surgery. But +without a functioning hippocampus, HM was unable to record new +experiences. For example, he would be horrified when looking in a +mirror, since he saw the face of an old man but thought he was still +twenty-five. But mercifully, the memory of being horrified would also +soon disappear into the fog. In some sense, HM was like an animal with +Level II consciousness, unable to recall the immediate past or simulate +the future. Without a functioning hippocampus, he regressed from Level +III down to Level II consciousness. + +Today, further advances in neuroscience have given us the clearest +picture yet of how memories are formed, stored, and then recalled. “It +has all come together just in the past few years, due to two technical +developments—computers and modern brain scanning,” says Dr. +Stephen Kosslyn, a neuroscientist at Harvard." +"As we know, sensory information (e.g., vision, touch, taste) must first +pass through the brain stem and onto the thalamus, which acts like a +relay station, directing the signals to the various sensory lobes of the +brain, where they are evaluated. The processed information reaches the +prefrontal cortex, where it enters our consciousness and forms what we +consider our short-term memory, which can range from several seconds +to minutes. (See Figure 11.)" +"To store these memories for a longer duration, the information must +then run through the hippocampus, where memories are broken down +into different categories. Rather than storing all memories in one area of +the brain like a tape recorder or hard drive, the hippocampus redirects +the fragments to various cortices. (Storing memories in this way is +actually more efficient than storing them sequentially. If human +memories were stored sequentially, like on computer tape, a vast +amount of memory storage would br required. In fact, in the future, even +digital storage systems may adopt this trick from the living brain, rather +than storing whole memories sequentially.) For instance, emotional +memories are stored in the amygdala, but words are recorded in the +temporal lobe. Meanwhile, colors and other visual information are +collected in the occipital lobe, and the sense of touch and movement +reside in the parietal lobe. So far, scientists have identified more than" +"reside in the parietal lobe. So far, scientists have identified more than +twenty categories of memories that are stored in different parts of the +brain, including fruits and vegetables, plants, animals, body parts, +colors, numbers, letters, nouns, verbs, proper names, faces, facial +expressions, and various emotions and sounds." +"Figure 11. This shows the path taken to create memories. Impulses from the senses pass through the +brain stem, to the + + thalamus, out to the various cortices, and then to the prefrontal cortex. They then pass to the +hippocampus to form long¬ +term memories, (illustration credit 5.1) + +A single memory—for instance, a walk in the park—involves +information that is broken down and stored in various regions of the +brain, but reliving just one aspect of the memory (e.g., the smell of +freshly cut grass) can suddenly send the brain racing to pull the +fragments together to form a cohesive recollection. The ultimate goal of +memory research is, then, to figure out how these scattered fragments +are somehow reassembled when we recall an experience. This is called +the “binding problem,” and a solution could potentially explain many +puzzling aspects of memory. For instance, Dr. Antonio Damasio has +analyzed stroke patients who are incapable of identifying a single" +"category, even though they are able to recall everything else. This is +because the stroke has affected just one particular area of the brain, +where that certain category was stored. + +The binding problem is further complicated because all our memories +and experiences are highly personal. Memories might be customized for +the individual, so that the categories of memories for one person may +not correlate with the categories of memories for another. Wine tasters, +for example, may have many categories for labeling subtle variations in +taste, while physicists may have other categories for certain equations. +Categories, after all, are by-products of experience, and different people +may therefore have different categories." +"One novel solution to the binding problem uses the fact that there are +electromagnetic vibrations oscillating across the entire brain at roughly +forty cycles per second, which can be picked up by EEG scans. One +fragment of memory might vibrate at a very precise frequency and +stimulate another fragment of memory stored in a distant part of the +brain. Previously it was thought that memories might be stored +physically close to one another, but this new theory says that memories +are not linked spatially but rather temporally, by vibrating in unison. If +this theory holds up, it means that there are electromagnetic vibrations +constantly flowing through the entire brain, linking up different regions +and thereby re-creating entire memories. Hence the constant flow of +information between the hippocampus, the prefrontal cortex, the +thalamus, and the different cortices might not be entirely neural after +all. Some of this flow may be in the form of resonance across different +brain structures." +"RECORDING A MEMORY + + Sadly, HM died in 2008 at the age of eighty-two, before he could take +advantage of some sensational results achieved by science: the ability to +create an artificial hippocampus and then insert memories into the brain. +This is something straight out of science fiction, but scientists at Wake +Forest University and the University of Southern California made history +in 2011 when they were able to record a memory made by mice and +store it digitally in a computer. This was a proof-of-principle experiment, + +in which they showed that the dream of downloading memories into the +brain might one day become reality." +"At first, the very idea of downloading memories into the brain seems +like an impossible dream, because, as we have seen, memories are +created by processing a variety of sensory experiences, which are then +stored in multiple places in the neocortex and limbic system. But as we +know from HM, there is one place through which all memories flow and +are converted into long-term memories: the hippocampus. Team leader +Dr. Theodore Berger of USC says, “If you can’t do it with the +hippocampus, you can’t do it anywhere.”" +"The scientists at Wake Forest and USC first started with the +observation, garnered from brain scans, that there are at least two sets of +neurons in a mouse’s hippocampus, called CA1 and CA3, which +communicate with each other as a new task is learned. After training +mice to press two bars, one after the other, in order to get water, the +scientists reviewed the findings and attempted to decode these messages, +which proved frustrating at first since the signals between these two sets +of neurons didn’t appear to follow a pattern. But by monitoring the +signals millions of times, they were eventually able to determine which +electrical input created which output. With the use of probes in the +mice’s hippocampi, the scientists were able to record the signals between +CA1 and CA3 when the mice learned to press the two bars in sequence." +"Then the scientists injected the mice with a special chemical, making +them forget the task. Finally they played back the memory into the same +mouse’s brain. Remarkably, the memory of the task returned, and the +mice could successfully reproduce the original task. Essentially, they had +created an artificial hippocampus with the ability to duplicate digital +memory. “Turn the switch on, the animal has the memory; turn it off +and they don’t,” says Dr. Berger. “It’s a very important step because it’s +the first time we have put all the pieces together.” + +As Joel Davis of the Office of the Chief of Naval Operations, which +sponsored this work, said, “Using implantables to enhance competency is +down the road. It’s only a matter of time.”" +"Not surprisingly, with so much at stake, this area of research is +moving very rapidly. In 2013, yet another breakthrough was made, this +time at MIT, by scientists who were able to implant not just ordinary +memories into a mouse, but false ones as well. This means that, one day, + +memories of events that never took place may be implanted into the +brain, which would have a profound impact on fields like education and +entertainment. + +The MIT scientists used a technique called optogenetics (which we will +discuss more in Chapter 8), which allows you to shine a light on specific +neurons to activate them. Using this powerful method, scientists can +identify the specific neurons responsible for certain memories." +"Let’s say that a mouse enters a room and is given a shock. The neurons +responsible for the memory of that painful event can actually be isolated +and recorded by analyzing the hippocampus. Then the mouse is placed +in an entirely different room that is totally harmless. By turning on a +light on an optical fiber, one can use optogenetics to activate the +memory of the shock, and the mouse exhibits a fear response, although +the second room is totally safe. + +In this way, the MIT scientists were able not only to implant ordinary +memories, but also memories of events that never took place. One day, +this technique may give educators the ability to implant memories of +new skills to retrain workers, or give Hollywood an entirely new form of +entertainment. + +AN ARTIFICIAL HIPPOCAMPUS" +"AN ARTIFICIAL HIPPOCAMPUS + +At present, the artificial hippocampus is primitive, able to record only a +single memory at a time. But these scientists plan to increase the +complexity of their artificial hippocampus so that it can store a variety +of memories and record them for different animals, eventually working +up to monkeys. They also plan to make this technology wireless by +replacing the wires with tiny radios so that memories can be +downloaded remotely without the need for clumsy electrodes implanted +into the brain. + +Because the hippocampus is involved with memory processing in +humans, scientists see a vast potential application in treating strokes, +dementia, Alzheimer’s, and a host of other problems that occur when +there is damage or deterioration in this region of the brain. + + Many hurdles have to be negotiated, of course. Despite all we have +learned about the hippocampus since HM, it still remains something of a" +"black box whose inner workings are largely unknown. As a result, it is +not possible to construct a memory from scratch, but once a task has +been performed and the memory processed, it is possible to record it and +play it back. + +FUTURE DIRECTIONS + +Working with the hippocampus of primates and even humans will be +more difficult, since their hippocampi are much larger and more +complex. The first step is to create a detailed neural map of the +hippocampus. This means placing electrodes at different parts of the +hippocampus to record the signals that are constantly being exchanged +between different regions. This will establish the flow of information +that constantly moves across the hippocampus. The hippocampus has +four basic divisions, CA1 to CA4, and hence scientists will record the +signals that are exchanged between them." +"The second step involves the subject performing certain tasks, after +which scientists will record the impulses that flow across the various +regions of the hippocampus, thereby recording the memory. For +example, the memory of learning a certain task, such as jumping +through a hoop, will create electrical activity in the hippocampus that +can be recorded and carefully analyzed. Then a dictionary can be +created matching the memory with the flow of information across the +hippocampus. + +Finally, step three involves making a recording of this memory and +feeding the electrical signal into the hippocampus of another subject via +electrodes, to see if that memory can been uploaded. In this fashion, the +subject may learn to jump through a hoop although it has never done so +before. If successful, scientists would gradually create a library +containing recordings of certain memories." +"It may take decades to work all the way up to human memories, but +one can envision how it might work. In the future, people may be hired +to create certain memories, like a luxury vacation or a fictitious battle. +Nanoelectrodes will be placed at various places in their brain to record +the memory. These electrodes must be extremely small so that they do +not interfere with the formation of the memory. + +The information from these electrodes will then be sent wirelessly to a + + computer and then recorded. Later a subject who wants to experience +these memories will have similar electrodes placed in his hippocampus, +and the memory will be inserted into the brain." +"(There are complications to this idea, of course. If we try to insert the +memory of physical activity, such as a martial art, we have the problem +of “muscle memory.” For example, when walking, we do not consciously +think about putting one leg in front of the other. Walking has become +second nature to us because we do it so often, and from an early age. +This means that the signals controlling our legs no longer originate +entirely in the hippocampus, but also in the motor cortex, the +cerebellum, and the basal ganglia. In the future, if we wish to insert +memories involving sports, scientists may have to decipher the way in +which memories are partially stored in other areas of the brain as well.) + +VISION AND HUMAN MEMORIES" +"VISION AND HUMAN MEMORIES + +The formation of memories is quite complex, but the approach we have +been discussing takes a shortcut by eavesdropping on the signals moving +through the hippocampus, where the sensory impulses have already +been processed. In The Matrix, however, an electrode is placed in the +back of the head to upload memories directly into the brain. This +assumes that one can decode the raw, unprocessed impulses coming in +from the eyes, ears, skin, etc., that are moving up the spinal cord and +brain stem and into the thalamus. This is much more elaborate and +difficult than analyzing the processed messages circulating in the +hippocampus." +"To give you a sense of the sheer volume of unprocessed information +that comes up the spinal cord into the thalamus, let’s consider just one +aspect: vision, since many of our memories are encoded this way. There +are roughly 130 million cells in the eye’s retina, called cones and rods; +they process and record 100 million bits of information from the +landscape at any time. + +This vast amount of data is then collected and sent down the optic +nerve, which transports 9 million bits of information per second, and on +to the thalamus. From there, the information reaches the occipital lobe, + +at the very back of the brain. This visual cortex, in turn, begins the +arduous process of analyzing this mountain of data. The visual cortex +consists of several patches at the back of the brain, each of which is +designed for a specific task. They are labeled VI to V8. + +Remarkably, the area called VI is like a screen; it actually creates a" +"Remarkably, the area called VI is like a screen; it actually creates a + + pattern on the back of your brain very similar in shape and form to the +original image. This image bears a striking resemblance to the original, +except that the very center of your eye, the fovea, occupies a much +larger area in VI (since the fovea has the highest concentration of +neurons). The image cast on VI is therefore not a perfect replica of the +landscape but is distorted, with the central region of the image taking up +most of the space. + +Besides VI, other areas of the occipital lobe process different aspects +of the image, including: + +• Stereo vision. These neurons compare the images coming in from +each eye. This is done in area V2. + +• Distance. These neurons calculate the distance to an object, using +shadows and other information from both eyes. This is done in area +V3. + +• Colors are processed in area V4." +"• Colors are processed in area V4. + +• Motion. Different circuits can pick out different classes of motion, +including straight-line, spiral, and expanding motion. This is done in +area V5. + +More than thirty different neural circuits involved with vision have +been identified, but there are probably many more. + +From the occipital lobe, the information is sent to the prefrontal +cortex, where you finally “see” the image and form your short-term +memory. The information is then sent to the hippocampus, which +processes it and stores it for up to twenty-four hours. The memory is +then chopped up and scattered among the various cortices. + +The point here is that vision, which we think happens effortlessly, +requires billions of neurons firing in sequence, transmitting millions of +bits of information per second. And remember that we have signals from +five sense organs, plus emotions associated with each image. All this" +"information is processed by the hippocampus to create a simple memory +of an image. At present, no machine can match the sophistication of this +process, so replicating it presents an enormous challenge for scientists +who want to create an artificial hippocampus for the human brain. + +REMEMBERING THE FUTURE + + If encoding the memory of just one of the senses is such a complex +process, then how did we evolve the ability to store such vast amounts of +information in our long-term memory? Instinct, for the most part, guides +the behavior of animals, which do not appear to have much of a long¬ +term memory. But as neurobiologist Dr. James McGaugh of the +University of California at Irvine says, “The purpose of memory is to +predict the future,” which raises an interesting possibility. Perhaps long¬ +term memory evolved because it was useful for simulating the future. In +other words, the fact that we can remember back into the distant past is +due to the demands and advantages of simulating the future." +"Indeed, brain scans done by scientists at Washington University in St. +Louis indicate that areas used to recall memories are the same as those +involved in simulating the future. In particular, the link between the +dorsolateral prefrontal cortex and the hippocampus lights up when a +person is engaged in planning for the future and remembering the past. +In some sense, the brain is trying to “recall the future,” drawing upon +memories of the past in order to determine how something will evolve +into the future. This may also explain the curious fact that people who +suffer from amnesia—such as HM—are often unable to visualize what +they will be doing in the future or even the very next day." +"“You might look at it as mental time travel—the ability to take +thoughts about ourselves and project them either into the past or into +the future,” says Dr. Kathleen McDermott of Washington University. She +also notes that their study proves a “tentative answer to a longstanding +question regarding the evolutionary usefulness of memory. It may just be +that the reason we can recollect the past in vivid detail is that this set of +processes is important for being able to envision ourselves in future +scenarios. This ability to envision the future has clear and compelling +adaptive significance.” For an animal, the past is largely a waste of + +precious resources, since it gives them little evolutionary advantage. But +simulating the future, given the lessons of the past, is an essential reason +why humans became intelligent. + +AN ARTIFICIAL CORTEX" +"AN ARTIFICIAL CORTEX + +In 2012 the same scientists from Wake Forest Baptist Medical Center and +the University of Southern California who created an artificial +hippocampus in mice announced an even more far-reaching experiment. +Instead of recording a memory in the mouse hippocampus, they +duplicated the much more sophisticated thinking process of the cortex of +a primate." +"They took five rhesus monkeys and inserted tiny electrodes into two +layers of their cortex, called the L2/3 and L5 layers. They then recorded +neural signals that went between these two layers as the monkeys +learned a task. (This task involved the monkeys seeing a set of pictures, +and then being rewarded if they could pick out these same pictures from +a much larger set.) With practice, the monkeys could perform the task +with 75 percent accuracy. But if the scientists fed the signal back into +the cortex as the monkey was performing the test, its performance +increased by 10 percent. When certain chemicals were given to the +monkey, its performance dropped by 20 percent. But if the recording +was fed back into the cortex, its performance exceeded its normal level. +Although this was a small sample size and there was only a modest +improvement in performance, the study still suggests that the scientists’ +recording accurately captured the decision-making process of the cortex." +"Because this study was done on primates rather than mice and +involved the cortex and not the hippocampus, it could have vast +implications when human trials begin. Dr. Sam A. Deadwyler of Wake +Forest says, “The whole idea is that the device would generate an output +pattern that bypasses the damaged area, proving an alternative +connection” in the brain. This experiment has a possible application for +patients whose neocortex has been damaged. Like a crutch, this device +would perform the thinking operation of the damaged area. + +AN ARTIFICIAL CEREBELLUM + +It should also be pointed out that the artificial hippocampus and +neocortex are but the first steps. Eventually, other parts of the brain will +have artificial counterparts. For example, scientists at Tel Aviv +University in Israel have already created an artificial cerebellum for a +rat. The cerebellum is an essential part of the reptilian brain that +controls our balance and other basic bodily functions." +"Usually when a puff of air is directed at a rat’s face, it blinks. If a +sound is made at the same time, the rat can be conditioned to blink just +by hearing the sound. The goal of the Israeli scientists was to create an +artificial cerebellum that could duplicate this feat. + +First the scientists recorded the signals entering the brain stem when +the puff of air hit the rat’s face and the sound was heard. Then the signal +was processed and sent back to the brain stem at another location. As +expected, the rats blinked upon receiving the signal. Not only is this the +first time that an artificial cerebellum functioned correctly, it is the first +time that messages were received from one part of the brain, processed, +and then uploaded into a different part of the brain." +"Commenting on this work, Francesco Sepulveda of the University of +Essex says, “This demonstrates how far we have come towards creating +circuitry that could one day replace damaged brain areas and even +enhance the power of the healthy brain.” + +He also sees great potential for artificial brains in the future, adding, +“It will likely take us several decades to get there, but my bet is that +specific, well-organized brain parts such as the hippocampus or the +visual cortex will have synthetic correlates before the end of the +century.” + +Although progress in creating artificial replacements for the brain is +moving remarkably fast given the complexity of the process, it is a race +against time when one considers the greatest threat facing our public +health system, the declining mental abilities of people with Alzheimer’s. + +ALZHEIMER’S—DESTROYER OF MEMORY" +"ALZHEIMER’S—DESTROYER OF MEMORY + +Alzheimer’s disease, some people claim, might be the disease of the +century. There are 5.3 million Americans who currently have +Alzheimer’s, and the number is expected to quadruple by 2050. Five + +percent of people from age sixty-five to seventy-four have Alzheimer’s, +but more than 50 percent of those over eighty-five have it, even if they +have no obvious risk factors. (Back in 1900, life expectancy in the +United States was forty-nine, so Alzheimer’s was not a significant +problem. But now, people over eighty are one of the fastest-growing +demographic groups in the country.)" +"In the early stages of Alzheimer’s, the hippocampus, the part of the +brain through which memories are processed, begins to deteriorate. +Indeed, brain scans clearly show that the hippocampus shrinks in +Alzheimer’s patients, but the wiring linking the prefrontal cortex to the +hippocampus also thins, leaving the brain unable to properly process +short-term memories. Long-term memories already stored throughout +the cortices of the brain remain relatively intact, at least at first. This +creates a situation where you may not remember what you just did a few +minutes ago but can clearly recall events that took place decades ago. + +Eventually, the disease progresses to the point where even basic long¬ +term memories are destroyed. The person is unable to recognize their +children or spouse and to remember who they are, and can even fall into +a comalike vegetative state. + +Sadly, the basic mechanisms for Alzheimer’s have only recently begun" +"Sadly, the basic mechanisms for Alzheimer’s have only recently begun + + to be understood. One major breakthrough came in 2012, when it was +revealed that Alzheimer’s begins with the formation of tau amyloid +proteins, which in turn accelerates the formation of beta amyloid, a +gummy, gluelike substance that clogs up the brain. (Before, it was not +clear if Alzheimer’s was caused by these plaques or whether perhaps +these plaques were by-products of a more fundamental disorder.)" +"What makes these amyloid plaques so difficult to target with drugs is +that they are most likely made of “prions,” which are misshapen protein +molecules. They are not bacteria or viruses, but nevertheless they can +reproduce. When viewed atomically, a protein molecule resembles a +jungle of ribbons of atoms tied together. This tangle of atoms must fold +onto itself correctly for the protein to assume the proper shape and +function. But prions are misshapen proteins that have folded incorrectly. +Worse, when they bump into healthy proteins, they cause them to fold +incorrectly as well. Hence one prion can cause a cascade of misshapen +proteins, creating a chain reaction that contaminates billions more. + +At present, there is no known way to stop the inexorable progression" +"At present, there is no known way to stop the inexorable progression + +of Alzheimer’s. Now that the basic mechanics behind Alzheimer’s are +being unraveled, however, one promising method is to create antibodies +or a vaccine that might specifically target these misshapen protein +molecules. Another way might be to create an artificial hippocampus for +these individuals so that their short-term memory can be restored. + +Yet another approach is to see if we can directly increase the brain’s +ability to create memories using genetics. Perhaps there are genes that +can improve our memory. The future of memory research may lie in the +“smart mouse.” + +THE SMART MOUSE" +"THE SMART MOUSE + +In 1999, Dr. Joseph Tsien and colleagues at Princeton, MIT, and +Washington University found that adding a single extra gene +dramatically boosted a mouse’s memory and ability. These “smart mice” +could navigate mazes faster, remember events better, and outperform +other mice in a wide variety of tests. They were dubbed “Doogie mice,” +after the precocious character on the TV show Doogie Howser, M.D. + +Dr. Tsien began by analyzing the gene NR2B, which acts like a switch +controlling the brain’s ability to associate one event with another. +(Scientists know this because when the gene is silenced or rendered +inactive, mice lose this ability.) All learning depends on NR2B, because +it controls the communication between memory cells of the" +"hippocampus. First Dr. Tsien created a strain of mice that lacked NR2B, +and they showed impaired memory and learning disabilities. Then he +created a strain of mice that had more copies of NR2B than normal, and +found that the new mice had superior mental capabilities. Placed in a +shallow pan of water and forced to swim, normal mice would swim +randomly about. They had forgotten from just a few days before that +there was a hidden underwater platform. The smart mice, however, went +straight to the hidden platform on the first try. + +Since then, researchers have been able to confirm these results in +other labs and create even smarter strains of mice. In 2009, Dr. Tsien +published a paper announcing yet another strain of smart mice, dubbed +“Hobbie-J” (named after a character in Chinese cartoons). Hobbie-J was +able to remember novel facts (such as the location of toys) three times" +"longer than the genetically modified strain of mouse previously thought +to be the smartest. “This adds to the notion that NR2B is a universal +switch for memory formation,” remarked Dr. Tsien. “It’s like taking +Michael Jordon and making him a super Michael Jordan,” said graduate +student Deheng Wang. + +There are limits, however, even to this new mice strain. When these +mice were given a choice to take a left or right turn to get a chocolate +reward, Hobbie-J was able to remember the correct path for much +longer than the normal mice, but after five minutes he, too, forgot. “We +can never turn it into a mathematician. They are rats, after all,” says Dr. +Tsien. + +It should also be pointed out that some of the strains of smart mice +were exceptionally timid compared to normal mice. Some suspect that, if +your memory becomes too great, you also remember all the failures and +hurts as well, perhaps making you hesitant. So there is also a potential +downside to remembering too much." +"Next, scientists hope to generalize their results to dogs, since we share +so many genes, and perhaps also to humans. + +SMART FLIES AND DUMB MICE + +The NR2B gene is not the only gene being studied by scientists for its +impact on memory. In yet another groundbreaking series of experiments, +scientists have been able to breed a strain of fruit flies with +“photographic memory,” and also a strain of mice that are amnesiac. +These experiments may eventually explain many mysteries of our long¬ +term memory, such as why cramming for an exam is not the best way to + + study, and why we remember events if they are emotionally charged. +Scientists have found that there are two important genes, the CREB +activator (which stimulates the formation of new connections between +neurons) and the CREB repressor (which suppresses the formation of +new memories)." +"Dr. Jerry Yin and Timothy Tully of Cold Spring Harbor have been +doing interesting experiments with fruit flies. Normally it takes ten trials +for them to learn a certain task (e.g., detecting an odor, avoiding a +shock). Fruit flies with an extra CREB repressor gene could not form + +lasting memories at all, but the real surprise came when they tested fruit +flies with an extra CREB activator gene. They learned the task in just one +session. “This implies these flies have a photographic memory,” says Dr. +Tully. He said they are just like students “who could read a chapter of a +book once, see it in their mind, and tell you that the answer is in +paragraph three of page two seventy-four.”" +"This effect is not just restricted to fruit flies. Dr. Alcino Silva, also at +Cold Spring Harbor, has been experimenting with mice. He found that +mice with a defect in their CREB activator gene were virtually incapable +of forming long-term memories. They were amnesiac mice. But even +these forgetful mice could learn a bit if they had short lessons with rest +in between. Scientists theorize that we have a fixed amount of CREB +activator in the brain that can limit the amount we can learn in any +specific time. If we try to cram before a test, it means that we quickly +exhaust the amount of CREB activators, and hence we cannot learn any +more—at least until we take a break to replenish the CREB activators. + +“We can now give you a biological reason why cramming doesn’t +work,” says Dr. Tully. The best way to prepare for a final exam is to +mentally review the material periodically during the day, until the +material becomes part of your long-term memory." +"This may also explain why emotionally charged memories are so vivid +and can last for decades. The CREB repressor gene is like a filter, +cleaning out useless information. But if a memory is associated with a +strong emotion, it can either remove the CREB repressor gene or increase +levels of the CREB activator gene. + +In the future, we can expect more breakthroughs in understanding the +genetic basis of memory. Not just one but a sophisticated combination of +genes is probably required to shape the enormous capabilities of the +brain. These genes, in turn, have counterparts in the human genome, so +it is a distinct possibility that we can also enhance our memory and +mental skills genetically." +"However, don’t think that you will be able to get a brain boost +anytime soon. Many hurdles still remain. First, it is not clear if these +results apply to humans. Often therapies that show great promise in +mice do not translate well to our species. Second, even if these results +can be applied to humans, we do not know what their impact will be. +For example, these genes may help improve our memory but not affect" +"our general intelligence. Third, gene therapy (i.e., fixing broken genes) is +more difficult than previously thought. Only a small handful of genetic +diseases can be cured with this method. Even though scientists use +harmless viruses to infect cells with the “good” gene, the body still sends +antibodies to attack the intruder, often rendering the therapy useless. It’s +possible that the insertion of a gene to enhance memory would face a +similar fate. (In addition, the field of gene therapy suffered a major +setback a few years ago when a patient died at the University of +Pennsylvania during a gene therapy procedure. The work of modifying +human genes therefore faces many ethical and even legal questions.)" +"Human trials, then, will progress much more slowly than animal trials. +However, one can foresee the day when this procedure might be +perfected and become a reality. Altering our genes in this way would +require no more than a simple shot in the arm. A harmless virus would +then enter our blood, which would then infect normal cells by injecting +its genes. Once the “smart gene” is successfully incorporated into our +cells, the gene becomes active and releases proteins that would increase +our memory and cognitive skills by affecting the hippocampus and +memory formation. + +If the insertion of genes becomes too difficult, another possibility is to +insert the proper proteins directly into the body, bypassing the use of +gene therapy. Instead of getting a shot, we would swallow a pill. + +A SMART PILL" +"A SMART PILL + +Ultimately, one goal of this research is to create a “smart pill” that could +boost concentration, improve memory, and maybe increase our +intelligence. Pharmaceutical companies have experimented with several +drugs, such as MEM 1003 and MEM 1414, that do seem to enhance +mental function. + +Scientists have found that in animal studies, long-term memories are +made possible by the interaction of enzymes and genes. Learning takes +place when certain neural pathways are reinforced as specific genes are +activated, such as the CREB gene, which in turn emits a corresponding +protein. Basically, the more CREB proteins circulating in the brain, the + + faster long-term memories are formed. This has been verified in studies + +on sea mollusks, fruit flies, and mice. The key property of MEM 1414 is +that it accelerates the production of the CREB proteins. In lab tests, aged +animals given MEM 1414 were able to form long-term memories +significantly faster than a control group." +"Scientists are also beginning to isolate the precise biochemistry +required in the formation of long-term memories, at both the genetic and +the molecular level. Once the process of memory formation is completely +understood, therapies will be devised to accelerate and strengthen this +key process. Not only the aged and Alzheimer’s patients but eventually +the average person may well benefit from this “brain boost.” + +CAN MEMORIES BE ERASED?" +"CAN MEMORIES BE ERASED? + +Alzheimer’s may destroy memories indiscriminately, but what about +selectively erasing them? Amnesia is one of Hollywood’s favorite plot +devices. In The Bourne Identity, Jason Bourne (played by Matt Damon), a +skilled CIA agent, is found floating in the water, left for dead. When he +is revived, he has severe memory loss. He is being relentlessly chased by +assassins who want to kill him, but he does not know who he is, what +happened, or why they want him dead. The only clue to his memory is +his uncanny ability to instinctively engage in combat like a secret agent." +"It is well documented that amnesia can occur accidentally through +trauma, such as a blow on the head. But can memories be selectively +erased? In the film Eternal Sunshine of the Spotless Mind, starring Jim +Carrey, two people meet accidentally on a train and are immediately +attracted to each other. However, they are shocked to find that they +were actually lovers years ago but have no memory of it. They learn that +they paid a company to wipe memories of each other after a particularly +bad fight. Apparently, fate has given them a second chance at love. + +Selective amnesia was taken to an entirely new level in Men in Black, +in which Will Smith plays an agent from a shadowy, secret organization +that uses the “neuralizer” to selectively erase inconvenient memories of +UFOs and alien encounters. There is even a dial to determine how far +back the memories should be erased. + +All these make for thrilling plot lines and box-office hits, but are any +of them really possible, even in the future?" +"We know that amnesia is, indeed, possible, and that there are two +basic types, depending on whether short- or long-term memory has been +affected. “Retrograde amnesia” occurs when there is some trauma or +damage to the brain and preexisting memories are lost, usually dating +from the event that caused the amnesia. This would be similar to the +amnesia faced by Jason Bourne, who lost all memories from before he +was left for dead in the water. Here the hippocampus is still intact, so +new memories can be formed even though long-term memory has been +damaged. “Anterograde amnesia” occurs when short-term memory is +damaged, so the person has difficulty forming new memories after the +event that caused the amnesia. Usually, amnesia may last for minutes to +hours due to damage to the hippocampus. (Anterograde amnesia was +featured prominently in the movie Memento, where a man is bent on +revenge for the death of his wife. The problem, however, is that his" +"revenge for the death of his wife. The problem, however, is that his +memory lasts only about fifteen minutes, so he has to continually write +messages on scraps of papers, photos, and even tattoos in order to +remember the clues he has uncovered about the murderer. By painfully +reading this trail of messages he has written to himself, he can +accumulate crucial evidence that he would have soon forgotten.)" +"The point here is that memory loss dates back to the time of the +trauma or disease, which would make the selective amnesia of +Hollywood highly improbable. Movies like Men in Black assume that +memories are stored sequentially, as in a hard disk, so you just hit the +“erase” button after a designated point in time. However, we know that +memories are actually broken up, with separate pieces stored in different +places in the brain. + +A FORGETFUL DRUG + +Meanwhile, scientists are studying certain drugs that may erase +traumatic memories that continue to haunt and disturb us. In 2009, +Dutch scientists, led by Dr. Merel Kindt, announced that they had found +new uses for an old drug called propranolol, which could act like a +“miracle” drug to ease the pain associated with traumatic memories. The +drug did not induce amnesia that begins at a specific point in time, but it +did make the pain more manageable—and in just three days, the study + +claimed." +"claimed. + +The discovery caused a flurry of headlines, in light of the thousands of +victims who suffer from PTSD (post-traumatic stress disorder). Everyone +from war veterans to victims of sexual abuse and horrific accidents could +apparently find relief from their symptoms. But it also seemed to fly in +the face of brain research, which shows that long-term memories are" +"encoded not electrically, but at the level of protein molecules. Recent +experiments, however, suggest that recalling memories requires both the +retrieval and then the reassembly of the memory, so that the protein +structure might actually be rearranged in the process. In other words, +recalling a memory actually changes it. This may be the reason why the +drug works: propranolol is known to interfere with adrenaline +absorption, a key in creating the long-lasting, vivid memories that often +result from traumatic events. “Propranolol sits on that nerve cell and +blocks it. So adrenaline can be present, but it can’t do its job,” says Dr. +James McGaugh of the University of California at Irvine. In other words, +without adrenaline, the memory fades." +"Controlled tests done on individuals with traumatic memories showed +very promising results. But the drug hit a brick wall when it came to the +ethics of erasing memory. Some ethicists did not dispute its +effectiveness, but they frowned on the very idea of a forgetfulness drug, +since memories are there for a purpose: to teach us the lessons of life. +Even unpleasant memories, they said, serve some larger purpose. The +drug got a thumbs-down from the President’s Council on Bioethics. Its +report concluded that “dulling our memory of terrible things [would] +make us too comfortable with the world, unmoved by suffering, +wrongdoing, or cruelty.... Can we become numb to life’s sharpest +sorrows without also becoming numb to its greatest joys?” + +Dr. David Magus of Stanford University’s Center for Biomedical Ethics +says, “Our breakups, our relationships, as painful as they are, we learn +from some of those painful experiences. They make us better people.”" +"Others disagree. Dr. Roger Pitman of Harvard University says that if a +doctor encounters an accident victim who is in intense pain, “should we +deprive them of morphine because we might be taking away the full +emotional experience? Who would ever argue with that? Why should +psychiatry be different? I think that somehow behind this argument +lurks the notion that mental disorders are not the same as physical + +disorders.” + +How this debate is ultimately resolved could have direct bearing on +the next generation of drugs, since propranolol is not the only one +involved. + +In 2008, two independent groups, both working with animals, +announced other drugs that could actually erase memories, not just +manage the pain they cause. Dr. Joe Tsien of the Medical College of +Georgia and his colleagues in Shanghai stated that they had actually +eliminated a memory in mice using a protein called CaMKII, while +scientists at SUNY Downstate Medical Center in Brooklyn found that the" +"molecule PKMzeta could also erase memories. Dr. Andre Fenson, one of +the authors of this second study, said, “If further work confirms this +view, we can expect to one day see therapies based on PKMzeta memory +erasure.” Not only may the drug erase painful memories, it also “might +be useful in treating depression, general anxiety, phobias, post-traumatic +stress, and addictions,” he added. + +So far, research has been limited to animals, but human trials will +begin soon. If the results transfer from animals to humans, then a +forgetful pill may be a real possibility. It will not be the kind of pill seen +in Hollywood movies (which conveniently creates amnesia at a precise, +opportune time) but could have vast medical applications in the real +world for people haunted by traumatic memories. It remains to be seen, +though, how selective this memory erasure might be in humans. + +WHAT CAN GO WRONG?" +"WHAT CAN GO WRONG? + +There may come a day, however, when we can carefully register all the +signals passing through the hippocampus, thalamus, and the rest of the +limbic system and make a faithful record. Then, by feeding this +information into our brains, we might be able to reexperience the +totality of what another person went through. Then the question is: +What can go wrong? + +In fact, the implications of this idea were explored in a movie, +Brainstorm (1983), starring Natalie Wood, which was far ahead of its +time. In the movie, scientists create the Hat, a helmet full of electrodes +that can faithfully record all the sensations a person is experiencing." +"Later, a person can have precisely the same sensory experience by +playing that tape back into his brain. For fun, one person puts on the Hat +when he is making love and tape-records the experience. Then the tape +is put into a loop so the experience is greatly magnified. But when +another person unknowingly inserts the experience into his brain, he +nearly dies because of a sensory overload. Later, one of the scientists +experiences a fatal heart attack. But before she dies, she records her final +moments on tape. When another person plays the death tape into his +brain, he, too, has a sudden heart attack and dies. + +When news of this powerful machine finally leaks out, the military +wants to seize control. This sets off a power struggle between the +military, which views it as a powerful weapon, and the original +scientists, who want to use it to unlock the secrets of the mind. + +Brainstorm prophetically highlighted not only the promise of this" +"Brainstorm prophetically highlighted not only the promise of this + + technology but also its potential pitfalls. It was meant to be science +fiction, but some scientists believe that sometime in the future, these +very issues may play out in our headlines and in our courts. + +Earlier, we saw that there have been promising developments in +recording a single memory created by a mouse. It may take until mid¬ +century before we can reliably record a variety of memories in primates +and humans. But creating the Hat, which can record the totality of +stimulation entering into the brain, requires tapping into the raw, +sensory data surging up the spinal cord and into the thalamus. It may be +late in this century before this can be done. + +SOCIAL AND LEGAL ISSUES" +"SOCIAL AND LEGAL ISSUES + +Some aspects of this dilemma may play out in our lifetimes. On one +hand, we may reach a point where we can learn calculus by simply +uploading the skill. The educational system would be turned upside +down; perhaps it would free teachers to spend more time mentoring +students and giving them one-on-one attention in areas of cognition that +are less skill-based and cannot be mastered by hitting a button. The rote +memorization necessary to become a professional doctor, lawyer, or +scientist could also be drastically reduced through this method. + +In principle, it might even give us memories of vacations that never" +"In principle, it might even give us memories of vacations that never + +happened, prizes that we never won, lovers whom we never loved, or +families that we never had. It could make up for deficiencies, creating +perfect memories of a life never lived. Parents would love this, since +they could teach their children lessons taken from real memories. The +demand for such a device could be enormous. Some ethicists fear that +these fake memories would be so vivid that we would prefer to relive +imaginary lives rather than experiencing our real ones." +"The unemployed may also benefit from being able to learn new +marketable skills by having memories implanted. Historically, millions +of workers were left behind every time a new technology was +introduced, often without any safety net. That’s why we don’t have +many blacksmiths or wagon makers anymore. They turned into +autoworkers and other industrial workers. But retraining requires a large +amount of time and commitment. If skills can be implanted into the +brain, there would be an immediate impact on the world economic +system, since we wouldn’t have to waste so much human capital. (To +some degree, the value of a certain skill may be devalued if memories +can be uploaded into anyone, but this is compensated for by the fact that +the number and quality of skilled workers would vastly increase.)" +"The tourism industry will also experience a tremendous boost. One +barrier to foreign travel is the pain of learning new customs and +conversing with new phrases. Tourists would be able to share in the +experience of living in a foreign land, rather than getting bogged down +trying to master the local currency and the details of the transportation +system. (Although uploading an entire language, with tens of thousands +of words and expressions, would be difficult, it might be possible to +upload enough information to carry on a decent conversation.)" +"Inevitably, these memory tapes will find their way onto social media. +In the future, you might be able to record a memory and upload it to the +Internet for millions to feel and experience. Previously, we discussed a +brain-net through which you can send thoughts. But if memories can be +recorded and created, you might also be able to send entire experiences. +If you just won a gold medal at the Olympic Games, why not share the +agony and the ecstasy of victory by putting your memories on the web? +Maybe the experience will go viral and billions can share in your +moment’s glory. (Children, who are often at the forefront of video games +and social media, may make a habit of recording memorable experiences" +"and uploading them onto the Internet. Like taking a picture with a cell +phone, it would be second nature to them to record entire memories. +This would require both the sender and the receiver to have nearly +invisible nanowires connecting to their hippocampus. The information +would then be sent wirelessly to a server, which would convert the +message to a digital signal that can be carried by the Internet. In this +way, you could have blogs, message boards, social media, and chat +rooms where, instead of uploading pictures and videos, you would +upload memories and emotions.) + +A LIBRARY OF SOULS" +"A LIBRARY OF SOULS + +People may also want to have a geneology of memories. When searching +records of our ancestors, we see only a one-dimensional portrait of their +lives. Throughout human history, people have lived, loved, and died +without leaving a substantial record of their existence. Mostly we just +find the birth and death dates of our relatives, with little in between. +Today we leave a long trail of electronic documents (credit card receipts, +bills, e-mails, bank statements, etc.). By default, the web is becoming a +giant repository of all the documents that describe our lives, but this still +doesn’t tell anyone much about what we were thinking or feeling. +Perhaps in the far future, the web could become a giant library +chronicling not just the details of our lives but also our consciousness." +"In the future, people might routinely record their memories so their +descendants can share the same experiences. Visiting the library of +memories for your clan, you would be able to see and feel how they +lived, and also how you fit into the larger scheme of things. + +This means that anyone could replay our lives, long after we have +died, by hitting the “play” button. If this vision is correct, it means that +we might be able to “bring back” our ancestors for an afternoon chat, +simply by inserting a disk into the library and pushing a button. + +Meanwhile, if you want to share in the experiences of your favorite +historical figures, you might be able to have an intimate look into how +they felt as they confronted major crises in their lives. If you have a role +model and wish to know how they negotiated and survived the great +defeats of their life, you could experience their memory tapes and gain" +"valuable insight. Imagine being able to share the memories of a Nobel +Prize-winning scientist. You might get clues about how great discoveries +are made. Or you might be able to share the memories of great +politicians and statesmen as they made crucial decisions that affected +world history. + +Dr. Miguel Nicolelis believes all this will one day become reality. He +says, “Each of these perennial records would be revered as a uniquely +precious jewel, one among billions of equally exclusive minds that once +lived, loved, suffered, and prospered, until they, too, become +immortalized, not clad in cold and silent gravestones, but released +through vivid thoughts, intensely lived loves, and mutually endured +sorrows.” + +THE DARK SIDE OF TECHNOLOGY" +"THE DARK SIDE OF TECHNOLOGY + +Some scientists have pondered the ethical implications of this +technology. Almost every new medical discovery caused ethical concerns +when it was introduced. Some of them had to be restricted or banned +when proven harmful (like the sleeping drug thalidomide, which caused +birth defects). Others have been so successful they changed our +conception of who we are, such as test-tube babies. When Louise Brown, +the first test-tube baby, was born in 1978, it created such a media storm +that even the pope issued a document critical of this technology. But +today, perhaps your sibling, child, spouse, or even you may be a product +of in vitro fertilization. Like many technologies, eventually the public +will simply get used to the idea that memories can be recorded and +shared." +"Other bioethicists have different worries. What happens if memories +are given to us without our permission? What happens if these memories +are painful or destructive? Or what about Alzheimer’s patients, who are +eligible for memory uploads but are too sick to give permission? + +The late Bernard Williams, a philosopher at Oxford University, +worried that this device might disturb the natural order of things, which +is to forget. “Forgetting is the most beneficial process we possess,” he +says. + +If memories can be implanted like uploading computer files, it could" +"If memories can be implanted like uploading computer files, it could + +also shake the foundation of our legal system. One of the pillars of +justice is the eyewitness account, but what would happen if fake +memories were implanted? Also, if the memory of a crime can be +created, then it might secretly be implanted into the brain of an innocent +person. Or, if a criminal needs an alibi, he could secretly implant a +memory into another person’s brain, convincing him that they were +together when the crime was being committed. Furthermore, not just +verbal testimony but also legal documents would be suspect, since when +we sign affidavits and legal documents, we depend on our memory to +clarify what is true and false." +"Safeguards would have to be introduced. Laws will have to be passed +that clearly define the limits of granting or denying access to memories. +Just as there are laws limiting the ability of the police or third parties to +enter your home, there would be laws to prevent people from accessing +your memories without your permission. There would also have to be a +way to mark these memories so that the person realizes that they are +fake. Thus, he would still be able to enjoy the memory of a nice +vacation, but he would also know that it never happened." +"Taping, storing, and uploading our memories may allow us to record +the past and master new skills. But doing so will not alter our innate +ability to digest and process this large body of information. To do that, +we need to enhance our intelligence. Progress in this direction is +hindered by the fact that there is no universally accepted definition of +intelligence. However, there is one example of genius and intelligence +that no one can dispute, and that is Albert Einstein. Remarkably, sixty +years after his death, his brain is still yielding invaluable clues to the +nature of intelligence. + +Some scientists believe that, using a combination of electromagnetics, +genetics, and drug therapy, it may be possible to boost our intelligence +to the genius level. They cite the fact that random injuries to the brain +have been documented that can suddenly change a person of normal +ability into a “savant,” one whose spectacular mental and artistic ability" +"is off the scale. This can be achieved now by random accidents, but what +happens when science intervenes and illuminates the secret of this +process? + +The brain is wider than the sky +For, put them side by side +The one the other will contain +With ease, and you beside. + +—EMILY DICKINSON + +Talent hits a target no one else can hit. Genius hits a target no +one else can see. + +—ARTHUR SCHOPENHAUER + +6 EINSTEIN’S BRAIN AND ENHANCING OUR +INTELLIGENCE + +Albert Einstein’s brain is missing. + +Or, at least it was for fifty years, until the heirs of the doctor who +spirited it away shortly after his death in 1955 finally returned it to the +National Museum of Health and Medicine in 2010. Analysis of his brain +may help clarify these questions: What is genius? How do you measure +intelligence and its relationship to success in life? There are also +philosophical questions: Is genius a function of our genes, or is it more a +question of personal struggle and achievement?" +"And, finally, Einstein’s brain may help answer the key question: Can +we boost our own intelligence? + +The word “Einstein” is no longer a proper noun that refers to a specific +person. It now simply means “genius.” The picture that the name +conjures up (baggy pants, flaming white hair, disheveled looks) is +equally iconic and instantly recognizable. + +The legacy of Einstein has been enormous. When some physicists in +2011 raised the possibility that he was wrong, that particles could break +the light barrier, it created a firestorm of controversy in the physics +world that spilled over into the popular press. The very idea that +relativity, which forms the cornerstone of modern physics, could be +wrong had physicists around the world shaking their heads. As expected, +once the result was recalibrated, Einstein was shown to be right once + + again. It is always dangerous to go up against Einstein." +"again. It is always dangerous to go up against Einstein. + +One way to gain insight into the question “What is genius?” is to +analyze Einstein’s brain. Apparently on the spur of the moment, Dr. +Thomas Harvey, the doctor at the Princeton hospital who was +performing the autopsy on Einstein, decided to secretly preserve his +brain, against the knowledge and wishes of Einstein’s family. + +Perhaps he preserved Einstein’s brain with the vague notion that one +day it might unlock the secret of genius. Perhaps he thought, like many + +others, that there was a peculiar part of Einstein’s brain that was the seat +of his vast intelligence. Brian Burrell, in his book Postcards from the Brain +Museum, speculates that perhaps Dr. Harvey “got caught up in the +moment and was transfixed in the presence of greatness. What he +quickly discovered was that he had bitten off more than he could chew.”" +"What happened to Einstein’s brain after that sounds more like a +comedy than a science story. Over the years, Dr. Harvey promised to +publish his results of analyzing Einstein’s brain. But he was no brain +specialist, and kept making excuses. For decades, the brain sat in two +large mason jars filled with formaldehyde and placed in a cider box, +under a beer cooler. He had a technician slice the brain into 240 pieces, +and on rare occasions he would mail a few to scientists who wanted to +study them. Once, pieces were mailed to a scientist at Berkeley in a +mayonnaise container." +"Forty years later, Dr. Harvey drove across the country in a Buick +Skylark carrying Einstein’s brain in a Tupperware container, hoping to +return it to Einstein’s granddaughter Evelyn. She refused to accept it. +After Dr. Harvey’s death in 2007, it was left to his heirs to properly +donate his collection of slides and portions of Einstein’s brain to science. +The history of Einstein’s brain is so unusual that a TV documentary was +filmed about it. + +(It should be pointed out that Einstein’s brain was not the only one to +be preserved for posterity. The brain of one of the greatest geniuses of +mathematics, Carl Friedrich Gauss, often called the Prince of +Mathematicians, was also preserved by a doctor a century earlier. Back +then, the anatomy of the brain was largely unexplored, and no +conclusions could be drawn other than the fact that it had unusually +large convolutions or folds.)" +"One might expect that Einstein’s brain was far beyond an ordinary +human’s, that it must have been huge, perhaps with areas that were +abnormally large. In fact, the opposite has been found (it is slightly +smaller, not larger, than normal). Overall, Einstein’s brain is quite + + ordinary. If a neurologist did not know that this was Einstein’s brain, he +probably would not give it a second thought. + +The only differences found in Einstein’s brain were rather minor. A +certain part of his brain, called the angular gyri, was larger than normal, +with the inferior parietal regions of both hemispheres 15 percent wider" +"than average. Notably, these parts of the brain are involved in abstract +thought, in the manipulation of symbols such as writing and +mathematics, and in visual-spatial processing. But his brain was still +within the norm, so it is not clear whether the genius of Einstein lay in +the organic structure of his brain or in the force of his personality, his +outlook, and the times. In a biography that I once wrote of Einstein, +titled Einstein’s Cosmos, it was clear to me that certain features of his life +were just as important as any anomaly in his brain. Perhaps Einstein +himself said it best when he said, “I have no special talents.... I am only +passionately curious.” In fact, Einstein would confess that he had to +struggle with mathematics in his youth. To one group of schoolchildren, +he once confided, “No matter what difficulties you may have with +mathematics, mine were greater.” So why was Einstein Einstein?" +"First, Einstein spent most of his time thinking via “thought +experiments.” He was a theoretical physicist, not an experimental one, +so he was continually running sophisticated simulations of the future in +his head. In other words, his laboratory was his mind." +"Second, he was known to spend up to ten years or more on a single +thought experiment. From the age of sixteen to twenty-six, he focused on +the problem of light and whether it was possible to outrace a light beam. +This led to the birth of special relativity, which eventually revealed the +secret of the stars and gave us the atomic bomb. From the age of twenty- +six to thirty-six, he focused on a theory of gravity, which eventually gave +us black holes and the big-bang theory of the universe. And then from +the age of thirty-six to the end of his life, he tried to find a theory of +everything to unify all of physics. Clearly, the ability to spend ten or +more years on a single problem showed the tenacity with which he +would simulate experiments in his head." +"Third, his personality was important. He was a bohemian, so it was +natural for him to rebel against the establishment in physics. Not every +physicist had the nerve or the imagination to challenge the prevailing +theory of Isaac Newton, which had held sway for two hundred years +before Einstein. + +Fourth, the time was right for the emergence of an Einstein. In 1905, +the old physical world of Newton was crumbling in light of experiments +that clearly suggested a new physics was about to be born, waiting for a + + genius to show the way. For example, the mysterious substance called + +radium glowed in the dark all by itself indefinitely, as if energy was +being created out of thin air, violating the theory of conservation of +energy. In other words, Einstein was the right man for the times. If +somehow it becomes possible to clone Einstein from the cells in his +preserved brain, I suspect that the clone would not be the next Einstein. +The historic circumstances must also be right to create a genius." +"The point here is that genius is perhaps a combination of being born +with certain mental abilities and also the determination and drive to +achieve great things. The essence of Einstein’s genius was probably his +extraordinary ability to simulate the future through thought +experiments, creating new physical principles via pictures. As Einstein +himself once said, “The true sign of intelligence is not knowledge, but +imagination.” And to Einstein, imagination meant shattering the +boundaries of the known and entering the domain of the unknown. + +All of us are born with certain abilities that are programmed into our +genes and the structure of our brains. That is the luck of the draw. But +how we arrange our thoughts and experiences and simulate the future is +something that is totally within our control. Charles Darwin himself once +wrote, “I have always maintained that, excepting fools, men did not +differ much in intellect, only in zeal and hard work.” + +CAN GENIUS BE LEARNED?" +"CAN GENIUS BE LEARNED? + +This rekindles the question, Are geniuses made or born? How does the +nature/nurture debate solve the mystery of intelligence? Can an ordinary +person become a genius? + +Since brain cells are notoriously hard to grow, it was once thought +that intelligence was fixed by the time we became young adults. But one +thing is becoming increasingly clear with new brain research: the brain +itself can change when it learns. Although brain cells are not being +added in the cortex, the connections between neurons are changing +every time a new task is learned. + +For example, scientists in 2011 analyzed the brains of London’s +famous taxicab drivers, who have to laboriously memorize twenty-five +thousand streets in the dizzying maze that makes up modern London. It +takes three to four years to prepare for this arduous test, and only half + + the trainees pass." +"the trainees pass. + +Scientists at University College London studied the brains of these +drivers before they took the test, and then tested them again three to +four years afterward. Those trainees who passed the test had a larger +volume of gray matter than before, in an area called the posterior and +the anterior hippocampus. The hippocampus, as we’ve seen, is where +memories are processed. (Curiously, tests also showed that these taxicab +drivers scored less than normal on processing visual information, so +perhaps there is a trade-off, a price to pay for learning this volume of +information.) + +“The human brain remains ‘plastic,’ even in adult life, allowing it to +adapt when we learn new tasks,” says Eleanor Maguire of the Wellcome +Trust, which funded the study. “This offers encouragement for adults +who want to learn new skills later in life.”" +"Similarly, the brains of mice that have learned many tasks are slightly +different from the brains of other mice that have not learned these tasks. +It is not so much that the number of neurons has changed, but rather +that the nature of the neural connections has been altered by the +learning process. In other words, learning actually changes the structure +of the brain. + +This raises the old adage “practice makes perfect.” Canadian +psychologist Dr. Donald Hebb discovered an important fact about the +wiring of the brain: the more we exercise certain skills, the more certain +pathways in our brains become reinforced, so the task becomes easier. +Unlike a digital computer, which is just as dumb today as it was +yesterday, the brain is a learning machine with the ability to rewire its +neural pathways every time it learns something. This is a fundamental +difference between a digital computer and the brain." +"This lesson applies not only to London taxicab drivers, but also to +accomplished concert musicians as well. According to psychologist Dr. K. +Anders Ericsson and colleagues, who studied master violinists at Berlin’s +elite Academy of Music, top concert violinists could easily rack up ten +thousand hours of grueling practice by the time they were twenty years +old, practicing more than thirty hours per week. By contrast, he found +that students who were merely exceptional studied only eight thousand +hours or fewer, and future music teachers practiced only a total of four +thousand hours. Neurologist Daniel Levitin says, “The emerging picture + +from such studies is that ten thousand hours of practice is required to +achieve the level of mastery associated with being a world-class expert— +in anything.... In study after study, of composers, basketball players, +fiction writers, ice skaters, concert pianists, chess players, master" +"criminals, and what have you, this number comes up again and again.” +Malcolm Gladwell, writing in the book Outliers, calls this the “10,000- +hour rule.” + +HOW DO YOU MEASURE INTELLIGENCE? + +But how do you measure intelligence? For centuries, any discussion of +intelligence relied on hearsay and anecdote. But now MRI studies have +shown that the principal activity of the brain while performing these +mathematical puzzles involves the pathway connecting the prefrontal +cortex (which engages in rational thought) with the parietal lobes +(which processes numbers). This correlates with the anatomical studies +of Einstein’s brain, which showed that his inferior parietal lobes were +larger than normal. So it is conceivable that mathematical ability +correlates with increased information flows between the prefrontal +cortex and the parietal lobes. But did the brain increase in size in this +area because of hard work and study, or was Einstein born that way? +The answer is still not clear." +"The key problem is that there is no uniformly accepted definition of +intelligence, let alone a consensus among scientists as to its origin. But +the answer may prove critical if we wish to enhance it. + +IQ EXAMS AND DR. TERMAN + +By default, the most widely used measure of intelligence is the IQ exam, +pioneered by Dr. Lewis Terman of Stanford University, who in 1916 +revised an earlier test devised by Alfred Binet for the French +government. For the next several decades, it became the gold standard +by which to measure intelligence. Terman, in fact, dedicated his life to +the proposition that intelligence could be measured and inherited, and +was the strongest predictor of success in life. + +Five years later, Terman started a landmark study on schoolchildren," +"Five years later, Terman started a landmark study on schoolchildren, + +The Genetic Studies of Genius. It was an ambitious project, whose scope +and duration were unprecedented back in the 1920s. It set the tone for +research in this field for an entire generation. He methodically +chronicled the successes and failures of these individuals throughout +their lives, compiling thick files of their achievements. These high-IQ +students were dubbed the “Termites.” + +At first, Dr. Terman’s idea seemed to be a resounding success. It" +"At first, Dr. Terman’s idea seemed to be a resounding success. It + + became the standard by which both children and other tests were +measured. During World War I, 1.7 million soldiers were given this test. +But over the years, a different profile began to slowly emerge. Decades +later, children who scored high on the IQ exam were only moderately +more successful than those who did not. Terman could proudly point to +some of his students who went on to win awards and secure well-paying +jobs. But he became increasingly disturbed by the large number of his +brightest students whom society would consider to be failures, taking +menial, dead-end jobs, engaging in crime, or leading lives on the +margins of society. These results were quite upsetting to Dr. Terman, +who had dedicated his life to proving that high IQ meant success in life. + +SUCCESS IN LIFE AND DELAYED GRATIFICATION" +"SUCCESS IN LIFE AND DELAYED GRATIFICATION + +A different approach was taken in 1972 by Dr. Walter Mischel, also of +Stanford, who analyzed yet another characteristic among children: the +ability to delay gratification. He pioneered the use of the “marshmallow +test,” that is, would children prefer one marshmallow now, or the +prospect of two marsh-mallows twenty minutes later? Six hundred +children, aged four to six, participated in this experiment. When Mischel +revisited the participants in 1988, he found that those who could delay +gratification were more competent than those who could not." +"In 1990, another study showed a direct correlation between those who +could delay gratification and SAT scores. And a study done in 2011 +indicated that this characteristic continued throughout a person’s life. +The results of these and other studies were eye-opening. The children +who exhibited delayed gratification scored higher on almost every +measure of success in life: higher-paying jobs, lower rates of drug +addiction, higher test scores, higher educational attainment, better social + +integration, etc." +"integration, etc. + +But what was most intriguing was that brain scans of these individuals +revealed a definite pattern. They showed a distinct difference in the way +the prefrontal cortex interacted with the ventral striatum, a region +involved in addiction. (This is not surprising, since the ventral striatum +contains the nucleus accumbens, known as the “pleasure center.” So +there seems to be a struggle here between the pleasure-seeking part of +the brain and the rational part to control temptation, as we saw in +Chapter 2.) + +This difference was no fluke. The result has been tested by many +independent groups over the years, with nearly identical results. Other +studies have also verified the difference in the frontal-striatal circuitry of + + the brain, which appears to govern delayed gratification. It seems that +the one characteristic most closely correlated with success in life, which +has persisted over the decades, is the ability to delay gratification." +"Although this is a gross simplification, what these brain scans show is +that the connection between the prefrontal and parietal lobes seems to +be important for mathematical and abstract thought, while the +connection between the prefrontal and limbic system (involving the +conscious control of our emotions and pleasure center) seems to be +essential for success in life. + +Dr. Richard Davidson, a neuroscientist at the University of Wisconsin- +Madison, concludes, “Your grades in school, your scores on the SAT, +mean less for life success than your capacity to co-operate, your ability +to regulate your emotions, your capacity to delay your gratification, and +your capacity to focus your attention. Those skills are far more +important—all the data indicate—for life success than your IQ or your +grades.” + +NEW MEASURES OF INTELLIGENCE" +"NEW MEASURES OF INTELLIGENCE + +Clearly there have to be new ways to measure intelligence and success in +life. IQ exams are not useless, but they measure only one limited form of +intelligence. Dr. Michael Sweeney, author of Brain: The Complete Mind, +notes, “Tests don’t measure motivation, persistence, social skills, and a +host of other attributes of a life that’s well lived.”" +"The problem with many of these standardized tests is that there may +also be a subconscious bias due to cultural influences. In addition, these +tests are evaluating only one particular form of intelligence, which some +psychologists call “convergent” intelligence. Convergent intelligence +focuses on one line of thought, ignoring the more complex “divergent” +form of intelligence, which involves measuring differing factors. For +example, during World War II, the U.S. Army Air Forces asked scientists +to devise a psychological exam that would measure a pilot’s intelligence +and ability to handle difficult, unexpected situations. One question was: +If you are shot down deep in enemy territory and must somehow make it +back to friendly lines, what do you do? The results contradicted +conventional thinking." +"Most psychologists expected that the air force study would show that +pilots with high IQs would score highly on this test as well. Actually, the +reverse was true. The pilots who scored highest were the ones with +higher levels of divergent thinking, who could see through many +different lines of thought. Pilots who excelled at this, for example, were +able to think up a variety of unorthodox and imaginative methods to + + escape after they were captured behind enemy lines." +"escape after they were captured behind enemy lines. + +The difference between convergent and divergent thinking is also +reflected in studies on split-brain patients, which clearly show that each +hemisphere of the brain is principally hardwired for one or the other. Dr. +Ulrich Kraft of Fulda, Germany, writes, “The left hemisphere is +responsible for convergent thinking and the right hemisphere for +divergent thinking. The left side examines details and processes them +logically and analytically but lacks a sense of overriding, abstract +connections. The right side is more imaginative and intuitive and tends +to work holistically, integrating pieces of an informational puzzle into a +whole.”" +"In this book, I take the position that human consciousness involves the +ability to create a model of the world and then simulate the model into +the future, in order to attain a goal. Pilots who demonstrated divergent +thinking were able to simulate many possible future events accurately +and with more complexity. Similarly, the children who mastered delayed +gratification in the famous marshmallow test appear to be the ones who +had the most ability to simulate the future, to see the long-term rewards +and not just the short-term, get-rich-quick schemes." +"A more sophisticated intelligence exam that directly quantifies a +person’s ability to simulate the future would be difficult but not +impossible to create. A person could be asked to create as many realistic +scenarios for the future as possible to win a game, with a score assigned +depending on the number of simulations the person can imagine and the +number of causal links involved with each one. Instead of measuring a +person’s ability to simply assimilate information, this new method would +measure a person’s ability to manipulate and mold this information to +achieve a higher goal. For example, a person might be asked to figure +out how to escape from a deserted island full of hungry wild animals and +poisonous snakes. He would have to list all the various ways to survive, +fend off the dangerous animals, and leave the island, creating an +elaborate causal tree of possible outcomes and futures." +"So we see that there is a common thread running through all this +discussion, and that is that intelligence seems to be correlated with the +complexity with which we can simulate future events, which correlates +with our earlier discussion of consciousness. + +But given the rapid advances taking place in the world’s laboratories +concerning electromagnetic fields, genetics, and drug therapies, is it +possible not just to measure our intelligence, but to enhance it as well— +to become another Einstein? + + BOOSTING OUR INTELLIGENCE + +This possibility was explored in the novel Flowers for Algernon (1958), +later made into the Academy Award-winning movie Charly (1968). In it, +we follow the sad life of Charly Gordon, who has an IQ of 68 and a +menial job in a bakery. He lives a simple life, fails to understand that his +fellow workers are constantly making fun of him, and does not even +know how to spell his own name." +"His only friend is Alice, a teacher who takes pity on him and tries to +teach him to read. But one day, scientists discover a new procedure that +can suddenly make ordinary mice intelligent. Alice hears about this and +decides to introduce Charly to these scientists, who agree to perform the +procedure on their first human subject. Within weeks, Charly has +noticeably changed. His vocabulary increases, he devours books from the + +library, he becomes something of a ladies’ man, and his room explodes +with modern art. Soon he begins to read about relativity and the +quantum theory, pushing the boundaries of advanced physics. He and +Alice even become lovers." +"But then the doctors notice that the mice have slowly lost their ability +and died. Realizing that he, too, might lose everything, Charly furiously +tries to use his superior intellect to find a cure, but instead he’s forced to +witness his own inexorable decline. His vocabulary shrinks, he forgets +mathematics and physics, and he slowly reverts back to his old self. In +the final scene, a heartbroken Alice watches as Charly plays with +children. + +The novel and movie, although poignant and critically acclaimed, +were dismissed as sheer science fiction. The plot was moving and +original, but the idea of boosting one’s intelligence was considered +preposterous. Brain cells cannot regenerate, scientists said, so this +movie’s plot was obviously impossible. + +But not anymore." +"But not anymore. + +Although it is still impossible to boost your intelligence, rapid +advances are being made in electromagnetic sensors, genetics, and stem +cells that may one day make this a real possibility. In particular, +scientific interest has focused on “autistic savants,” who possess +phenomenal, superhuman abilities that stagger the imagination. More +important, due to specific injuries to the brain, normal people can +rapidly acquire such near-miraculous powers. Some scientists even +believe that these uncanny abilities might be induced using +electromagnetic fields. + + SAVANTS: SUPER GENIUSES? + +A bullet went crashing through the skull of Mr. Z when he was nine +years old. It did not kill him, as his doctors feared, but wreaked +extensive damage to the left side of his brain, causing paralysis of the +right side of his body and leaving him permanently deaf and mute." +"However, the bullet also had a bizarre side effect. Mr. Z developed +supernormal mechanical abilities and a prodigious memory, typical of +“savants.” + +Mr. Z is not alone. In 1979, a ten-year-old boy named Orlando Serrell +was knocked unconscious by a baseball that hit the left side of his head. +At first, he complained of severe headaches. But after the pain subsided, +he was able to do remarkable mathematical calculations and had a near¬ +photographic memory of certain events happening in his life. He could +calculate dates thousands of years into the future. + +In the entire world of roughly seven billion people, there are only +about one hundred documented cases of these astounding savants. (The +number is much larger if we include those whose mental skills are still +extraordinary but not superhuman. It is believed that about 10 percent +of autistic individuals show some savant capabilities.) These +extraordinary savants possess abilities far beyond our current scientific +understanding." +"There are several types of savants that have recently elicited the +curiosity of scientists. About half of savants have some form of autism +(the other half display other forms of mental illness or psychological +disorder). They often have profound problems interacting socially, +leading to deep isolation. + +Then there is the “acquired savant syndrome,” in which people who +appear perfectly normal suffer from some extreme trauma later in life +(e.g., hitting their head on the bottom of a swimming pool or being +struck by a baseball or a bullet), almost always on the left side of their +brain. Some scientists, however, suggest that this distinction is +misleading, that perhaps all savant skills are acquired. Since autistic +savants begin to show their abilities around age three or four, perhaps +their autism (like a blow to their head) is the origin of their abilities." +"There is scientific disagreement about the origin of these extraordinary +abilities. Some believe that these individuals are simply born this way +and hence are unique, one-of-a-kind anomalies. Their skills, even if + + awakened by a bullet, are hardwired into their brains from birth. If so, +then perhaps this skill can never be learned or transferred. + +Others claim that such hardwiring violates the theory of evolution, +which takes place incrementally over long periods of time. If savant +geniuses exist, then the rest of us must also possess similar abilities, +although they are latent. Does this mean, then, that one day we might be +able to turn on these miraculous powers at will? Some believe so, and +there are even published papers claiming that some savant skills are" +"latent in all of us and can be brought to light using the magnetic fields +generated by an electromagnetic scanner (TES). Or perhaps there is a +genetic basis to this skill, in which case gene therapy might re-create +these astonishing abilities. It might also be possible to cultivate stem +cells that would allow neurons to grow in the prefrontal cortex and other +key centers of the brain. Then we might be able to increase our mental +abilities. + +All these avenues are the source of much speculation and research. +Not only might they allow doctors to reverse the ravages of diseases like +Alzheimer’s, but they could also enable us to enhance our own +intelligence. The possibilities are intriguing." +"The first documented case of a savant was recorded in 1789 by Dr. +Benjamin Rush, who studied an individual who seemed to be mentally +handicapped. Yet when he was asked how many seconds a man had +lived (who was seventy years, seventeen days, and twelve hours old), it +took him only ninety seconds to give the correct answer of +2,210,500,800. + +Dr. Darold Treffert, a Wisconsin physician, has studied these savants at +length. He recites one story of a blind savant who was asked a simple +question. If you put one corn kernel in the first square of a chess board, +two kernels in the second, four in the next, and keep doubling after that, +how many kernels would you have on the sixty-fourth square? It took +him just forty-five seconds to correctly reply: +18,446,744,073,709,551,616." +"Perhaps the best-known example of a savant was the late Kim Peek, +who was the inspiration for the movie Rain Man, starring Dustin +Hoffman and Tom Cruise. Although Kim Peek was severely mentally +handicapped (he was incapable of living by himself and could barely tie +his shoelaces or button his shirt), he memorized about twelve thousand +books and could recite lines from them, word for word, on any particular +page. It took him about eight seconds to read a page. (He could +memorize a book in about half an hour, but he read them in an unusual +way. He could read both pages simultaneously, using each eye to read a + + different page at the same time.) Although incredibly shy, he eventually +began to enjoy performing dazzling feats of mathematics before curious +onlookers, who would try to challenge him with tricky questions. + +Scientists, of course, have to be careful in distinguishing true savant" +"skills from simple memorization tricks. Their skills are not just +mathematical—they also extend to incredible musical, artistic, and +mechanical capabilities. Since autistic savants have great difficulty +verbally expressing their mental processes, another avenue is to +investigate individuals who have Asperger’s syndrome, which is a milder +form of autism. Only in 1994 was Asperger’s syndrome recognized as a +distinct psychological condition, so there is very little solid research in +this area. Like autistic individuals, people with Asperger’s have a +difficult time interacting socially with others. However, with proper +training, they can learn enough social skills to hold down a job and +articulate their mental processes. And a fraction of them have +remarkable savant skills. Some scientists believe that many great +scientists had Asperger’s syndrome. This might explain the strange, +reclusive nature of physicists like Isaac Newton and Paul Dirac (one of" +"reclusive nature of physicists like Isaac Newton and Paul Dirac (one of +the founders of the quantum theory). Newton, in particular, was +pathologically incapable of small talk." +"I had the pleasure of interviewing one such individual, Daniel +Tammet, who has written a best seller, Bom on a Blue Day. Almost alone +among these remarkable savants, he is able to articulate his thoughts in +books, on the radio, and in TV interviews. For someone who had such +difficulty relating to others as a child, he now has a superb grasp of +communication skills. + +Daniel has the distinction of setting a world record for memorizing pi, +a fundamental number in geometry. He was able to memorize it to +22,514 decimal places. I asked him how he prepared for such a +herculean feat. Daniel told me that he associates a color or texture with +every number. Then I asked him the key question: If every digit has a +color or texture, then how does he remember tens of thousands of them? +Sadly, at that point he said he doesn’t know. It just comes to him. +Numbers have been his life ever since he was a child, and hence they +simply appear in his mind. His mind is a constant mixture of numbers +and colors." +"ASPERGER’S AND SILICON VALLEY + +So far, this discussion may seem abstract, without any direct bearing on + + our daily lives. But the impact of people with mild autism and Asperger’s +may be more widespread than previously thought, especially in certain +high-tech fields. + +In the hit television series The Big Bang Theory, we follow the antics of +several young scientists, mainly nerdy physicists, in their awkward quest +for female companionship. In every episode, there is a hilarious incident +that reveals how clueless and pathetic they are in this endeavor." +"There is a tacit assumption running through the series that their +intellectual brilliance is matched only by their geekiness. And +anecdotally, people have noticed that among the high-tech gurus in +Silicon Valley, a higher percentage than normal seem to lack some social +skills. (There is a saying among women scientists who attend highly +specialized engineering universities, where the girl-to-guy ratio is +decidedly in their favor: “The odds are good, but the goods are odd.”) + +Scientists set out to investigate this suspicion. The hypothesis is that +people with Asperger’s and other mild forms of autism have mental skills +ideally suited for certain fields, like the information technology industry. +Scientists at University College London examined sixteen people who +were diagnosed with a mild form of autism and compared them with +sixteen normal individuals. Both groups were shown slides containing +random numbers and letters arranged in increasingly complex patterns." +"Their results showed that people with autism had a superior ability to +focus on the task. In fact, as the tasks became harder, the gap between +the intellectual skills of both groups began to widen, with the autistic +individuals performing significantly better than the control group. (The +test, however, also showed that these individuals were more easily +distracted by outside noises and blinking lights than the control group.) + +Dr. Nilli Lavie says, “Our study confirms our hypothesis that people +with autism have higher perceptual capacity compared to the typical +population.... People with autism are able to perceive significantly more +information than the typical adult.” + +This certainly does not prove that all people who are intellectually +brilliant have some form of Asperger’s. But it does indicate that fields +requiring the ability to focus intellectually might have a higher +proportion of people with Asperger’s. + +BRAIN SCANS OF SAVANTS" +"BRAIN SCANS OF SAVANTS + + The subject of savants has always been shrouded in hearsay and amazing +anecdotal stories. But recently, the entire field has been turned upside +down with the development of MRI and other brain scans. + +Kim Peek’s brain, for example, was unusual. MRI scans show that it +lacked the corpus callosum connecting the left and right brain, which is +probably why he could read two pages at the same time. His poor motor +skills were reflected in a deformed cerebellum, the area that controls +balance. Unfortunately, MRI scans could not reveal the exact origin of +his extraordinary abilities and photographic memory. But in general, +brain scans have shown that many suffering from acquired savant +syndrome have experienced damage to their left brain." +"In particular, interest has focused on the left anterior temporal and +orbitofrontal cortices. Some believe that perhaps all savant skills +(autistic, acquired, and Asperger’s) arise from damage to this very +specific spot in the left temporal lobe. This area can act like a “censor” +that periodically flushes out irrelevant memories. But after damage +occurs to the left hemisphere, the right hemisphere starts to take over. +The right brain is much more precise than the left brain, which often +distorts reality and confabulates. In fact, it is believed that the right +brain must work extra hard because of damage to the left brain, and +hence savant skills develop as a consequence. For example, the right +brain is much more artistic than the left brain. Normally, the left brain +restricts this talent and holds it in check. But if the left brain is injured in +a certain way, it may unleash the artistic abilities latent in the right +brain, causing an explosion of artistic talent. So the key to unleashing" +"brain, causing an explosion of artistic talent. So the key to unleashing +savant capabilities might be to dampen the left brain so that it can no +longer restrain the natural talents of the right brain. This is sometimes +referred to as “left brain injury, right brain compensation.”" +"In 1998, Dr. Bruce Miller of the University of California at San +Francisco performed a series of studies that seem to back this idea up. +He and coworkers studied five normal individuals who began to show +signs of frontotemporal dementia (FTD). As their dementia started to +progress, savant abilities gradually began to emerge. As their dementia +got worse, several of these individuals began to exhibit even more +extraordinary artistic ability, although none had shown gifts in this area + +before. Moreover, the abilities they exhibited were typical of savant +behavior. Their abilities were visual, not auditory, and their artworks, +remarkable as they were, were just copies lacking any original, abstract, +or symbolic qualities. (One patient actually got better during the study. +But her emerging savant skills were also reduced as a consequence. This +suggests a close relationship between emerging disorders of the left +temporal lobe and emerging savant skills.)" +"Dr. Miller’s analysis seemed to show that degeneration of the left +anterior temporal and orbitofrontal cortices probably decreased +inhibition of the visual systems in the right hemisphere, thereby +increasing artistic abilities. Again, damaging the left hemisphere in a +particular location forced the right hemisphere to take over and develop." +"In addition to the savants, MRI scans have also been done on people +with hyperthymestic syndrome, who also have photographic memories. +These people do not suffer from autism and mental disorders, but they +share some of their skills. In the entire United States, there are only four +documented cases of true photographic memory. One of them is Jill +Price, a school administrator in Los Angeles. She can recall precisely +what she was doing on any particular day going back decades. But she +complains that she finds it difficult to erase certain thoughts. Indeed, her +brain seems to be “stuck on autopilot.” She compares her memory to +watching the world through a split screen, in which the past and present +are constantly competing for her attention." +"Since 2000, scientists at the University of California at Irvine have +scanned her brain, and they’ve found it to be unusual. Several regions +were larger than normal, such as the caudate nuclei (which is involved +with forming habits) and the temporal lobe (which stores facts and +figures). It is theorized that these two areas work in tandem to create her +photographic memory. Her brain is therefore different from the brains of +savants who suffer an injury or damage to their left temporal lobe. The +reason is unknown, but it points to another path by which one may +obtain these fantastic mental abilities. + +CAN WE BECOME SAVANTS? + +All this raises the intriguing possibility that one might be able to + +deliberately deactivate parts of the left brain and thereby increase the +activity of the right brain, forcing it to acquire savant capabilities." +"We recall that transcranial magnetic stimulation, or TMS, allows one +to effectively silence parts of the brain. If so, then why can’t we silence +this part of the left anterior temporal and orbitofrontal cortices using the +TMS and turn on a savantlike genius at will? + +This idea has actually been tried. Dr. Allan Snyder of the University of +Sydney, Australia, made headlines a few years ago when he claimed +that, by applying the TMS to a certain part of the left brain, his subjects +could suddenly perform savantlike feats. By directing low-frequency +magnetic waves into the left hemisphere, one can in principle turn off" +"this dominant region of the brain so that the right hemisphere takes +over. Dr. Synder and his colleagues did an experiment with eleven male +volunteers. They applied the TMS to the subjects’ left frontotemporal +region while the subjects were performing tests involving reading and +drawing. This did not produce savant skills among the subjects, but two +of them had significant improvements in their ability to proofread words +and recognize duplicated words. In another experiment, Dr. R. L. Young +and his colleagues gave a battery of psychological tests to seventeen +individuals. The tests were specifically designed to test for savant skills. +(Tests of this sort analyze a person’s ability to memorize facts, +manipulate numbers and dates, create artwork, or perform music.) Five +of the subjects reported improvement in savantlike skills after treatment +with TMS." +"Dr. Michael Sweeney has observed, “When applied to the prefrontal +lobes, TMS has been shown to enhance the speed and agility of cognitive +processing. The TMS bursts are like a localized jolt of caffeine, but +nobody knows for sure how the magnets actually do their work.” These +experiments hint, but by no means prove, that silencing a part of the left +frontotemporal region could initiate some enhanced skills. These skills +are a far cry from savant abilities, and we should also be careful to point +out that other groups have looked into these experiments, and the results +have been inconclusive. More experimental work must be done, so it is +still too early to render a final judgment one way or the other. + +TMS probes are the easiest and most convenient instrument to use for +this purpose, since they can selectively silence various parts of the brain +at will without relying on brain damage and traumatic accidents. But it" +"should also be noted that TMS probes are still crude, silencing millions +of neurons at a time. Magnetic fields, unlike electrical probes, are not +precise but spread out over several centimeters. We know that the left +anterior temporal and orbitofrontal cortices are damaged in savants and +likely responsible, at least in some part, for their unique abilities, but +perhaps the specific area that must be dampened is an even smaller +subregion. So each jolt of TMS might inadvertently deactivate some of +the areas that need to remain intact in order to produce savantlike skills." +"In the future, with TMS probes we might be able to narrow down the +region of the brain involved with eliciting savant skills. Once this region +is identified, the next step would be to use highly accurate electrical +probes, like those used in deep brain stimulation, to dampen these areas +even more precisely. Then, with the push of a button, it might be +possible to use these probes to silence this tiny portion of the brain in +order to bring out savantlike skills. + + FORGETTING TO FORGET AND PHOTOGRAPHIC MEMORY + +Although savant skills may be initiated by some sort of injury to the left +brain (leading to right brain compensation), this still does not explain +precisely how the right brain can perform these miraculous feats of +memory. By what neural mechanism does photographic memory +emerge? The answer to this question may determine whether we can +become savants." +"Until recently, it was thought that photographic memory was due to +the special ability of certain brains to remember. If so, then it might be +difficult for the average person to learn these memory skills, since only +exceptional brains are capable of them. But in 2012, a new study showed +that precisely the opposite may be true. + +The key to photographic memory may not be the ability of remarkable +brains to learn; on the contrary, it may be their inability to forget. If this +is true, then perhaps photographic memory is not such a mysterious +thing after all. + +The new study was done by scientists at the Scripps Research Institute +in Florida who were working with fruit flies. They found an interesting +way in which these fruit flies learn, which may overturn a cherished idea + +of how memories are formed and forgotten. The fruit flies were exposed +to different smells and were given positive reinforcement (with food) or +negative reinforcement (with electric shocks)." +"The scientists knew that the neurotransmitter dopamine was important +to forming memories. To their surprise, they found that dopamine +actively regulates both the formation and the forgetting of new +memories. In the process of creating new memories, the dCAl receptor +was activated. By contrast, forgetting was initiated by the activation of +the DAMB receptor. + +Previously, it was thought that forgetting might be simply the +degradation of memories with time, which happens passively by itself. +This new study shows that forgetting is an active process, requiring +intervention by dopamine. + +To prove their point, they showed that by interfering with the action +of the dCAl and DAMB receptors, they could, at will, increase or +decrease the ability of fruit flies to remember and forget. A mutation in +the dCAl receptor, for example, impaired the ability of the fruit flies to +remember. A mutation in the DAMB receptor decreased their ability to +forget." +"The researchers speculate that this effect, in turn, may be partially +responsible for savants’ skills. Perhaps there is a deficiency in their +ability to forget. One of the graduate students involved in the study, +Jacob Berry, says, “Savants have a high capacity for memory. But maybe +it isn’t memory that gives them this capacity; maybe they have a bad +forgetting mechanism. This might also be the strategy for developing +drugs to promote cognition and memory—what about drugs that inhibit +forgetting as a cognitive enhancers?” + +Assuming that this result holds up in human experiments as well, it +could encourage scientists to develop new drugs and neurotransmitters +that are able to dampen the forgetting process. One might thus be able +to selectively turn on photographic memories when needed by +neutralizing the forgetting process. In this way, we wouldn’t have the +continuous overflow of extraneous, useless information, which hinders +the thinking of people with savant syndrome." +"What is also exciting is the possibility that the BRAIN project, which is +being championed by the Obama administration, might be able to +identify the specific pathways involved with acquired savant syndrome. + +Transcranial magnetic fields are still too crude to pin down the handful +of neurons that may be involved. But using nanoprobes and the latest in +scanning technologies, the BRAIN project might be able to isolate the +precise neural pathways that make possible photographic memory and +incredible computational, artistic, and musical skills. Billions of research +dollars will be channeled into identifying the specific neural pathways +involved with mental disease and other afflictions of the brain, and the +secret of savant skills may be revealed in the process. Then it might be +possible to take normal individuals and make savants out of them. This +has happened many times in the past because of random accidents. In +the future, this may become a precise medical process. Time will tell." +"So far, the methods analyzed here do not alter the nature of the brain +or the body. The hope is that through the use of magnetic fields, we will +be able to unleash the potential that already exists in our brains but is +latent. The philosophy underlying this idea is that we are all savants +waiting to happen, and it will just take some slight alteration of our +neural circuits to unleash this hidden talent. + +Yet another tactic is to directly alter the brain and the genes, using the +latest in brain science and also genetics. One promising method is to use +stem cells. + +STEM CELLS FOR THE BRAIN" +"STEM CELLS FOR THE BRAIN + + It was dogma for many decades that brain cells do not regenerate. It +seemed impossible that you could repair old, dying brain cells, or grow +new ones to boost your abilities, but all this changed in 1998. That year, +it was discovered that adult stem cells could be found in the +hippocampus, the olfactory bulb, and the caudate nucleus. In brief, stem +cells are the “mother of all cells.” Embryonic stem cells, for instance, can +readily develop into any other cell. Although each of our cells contains +all the genetic material necessary to construct a human being, only +embryonic stem cells have the ability to actually differentiate into any +type of cell in the body. + +Adult stem cells have lost that chameleon-like ability, but they can +still reproduce and replace old, dying cells. As far as memory +enhancement goes, interest has focused on adult stem cells in the" +"hippocampus. It turns out that thousands of new hippocampus cells are +born naturally each day, but most die soon afterward. However, it was +shown that rats that learned new skills retained more of their new cells. +A combination of exercise and mood-elevating chemicals can also boost +the survival rate of new hippocampus cells. It turns out that stress, on +the contrary, accelerates the death of new neurons." +"In 2007, a breakthrough occurred when scientists in Wisconsin and +Japan were able to take ordinary human skin cells, reprogram their +genes, and turn them into stem cells. The hope is that these stem cells, +either found naturally or converted using genetic engineering, can one +day be injected into the brains of Alzheimer’s patients to replace dying +cells. (These new brain cells, because they do not yet have the proper +connections, would not be integrated into the brain’s neural architecture. +This means that a person would have to relearn certain skills to +incorporate these fresh new neurons.) + +Stem cell research is naturally one of the most active areas in brain +research. “Stem cell research and regenerative medicine are in an +extremely exciting phase right now. We are gaining knowledge very fast +and many companies are being formed and are starting clinical trials in +different areas,” says Sweden’s Jonas Frisen of the Karolinska Institute. + +GENETICS OF INTELLIGENCE" +"GENETICS OF INTELLIGENCE + +In addition to stem cells, another avenue of exploration involves +isolating the genes responsible for human intelligence. Biologists note +that we are about 98.5 percent genetically identical to a chimpanzee, yet + + we live twice as long and have exploded in intellectual skills in the past +six million years. So among a handful of genes there must be the ones +responsible for giving us the human brain. Within a few years, scientists +will have a complete map of all these genetic differences, and the secret +to human longevity and enhanced intelligence may be found within this +tiny set. Scientists have focused on a few genes that possibly drove the +evolution of the human brain. + +So perhaps the clue to revealing the secret of intelligence lies in our +understanding of our apelike ancestors. This raises another question: Can +this research make possible the Planet of the Apes ?" +"In this long-running series of movies, a nuclear war destroys modern +civilization. Humanity is reduced to barbarism, but the radiation +somehow accelerates the evolution of the other primates, so that they +become the dominant species on the planet. They create an advanced +civilization, while humans are reduced to scruffy, smelly savages +roaming half naked in the forest. At best, humans become zoo animals. +The tables have turned on the humans, so the apes gawk at us outside +the bars of our cages." +"In the latest installment, The Rise of the Planet of the Apes, scientists are +looking for a cure for Alzheimer’s disease. Along the way, they stumble +on a virus that has the unintended consequence of increasing a +chimpanzee’s intelligence. Unfortunately, one of these enhanced apes is +treated cruelly when placed in a shelter for primates. Using his increased +intelligence, the ape breaks free, infects the other lab animals with the +virus to raise their intelligence, and then frees all of them from their +cages. Soon a caravan of shouting, intelligent apes runs amok on the +Golden Gate Bridge, completely overwhelming local and state police. +After a spectacular, harrowing confrontation with the authorities, the +movie ends with the apes peacefully finding refuge in a redwood forest +north of the bridge." +"Is such a scenario realistic? In the short term, no, but it can’t be ruled +out in the future, since scientists in the coming years should be able to +catalog all the genetic changes that created Homo sapiens. But many +more mysteries have to be solved before we have intelligent apes. + +One scientist who has been fascinated not by science fiction, but by +the genetics of what makes us “human,” is Dr. Katherine Pollard, an +expert in a field called “bioinformatics,” which barely existed a decade +ago. In this field of biology, instead of cutting open animals to +understand how they are put together, researchers use the vast power of +computers to mathematically analyze the genes in animals’ bodies. She +has been at the forefront of finding the genes that define the essence of +what separates us from the apes. Back in 2003, as a freshly minted Ph.D. + + from the University of California at Berkeley, she got her chance." +"from the University of California at Berkeley, she got her chance. + +“I jumped at the opportunity to join the international team that was +identifying the sequence of DNA bases, or ‘letters,’ in the genome of the +common chimpanzee,” she recalled. Her goal was clear. She knew that +only fifteen million base pairs, or “letters,” that make up our genome + +(out of three billion base pairs) separate us from the chimps, our closest +genetic neighbor. (Each “letter” in our genetic code refers to a nucleic +acid, of which there are four, labeled A,T,C, and G. So our genome +consists of three billion letters, arranged like ATTCCAGGG....) + +“I was determined to find them,” she wrote." +"“I was determined to find them,” she wrote. + +Isolating these genes could have enormous implications for our future. +Once we know the genes that gave rise to Homo sapiens, it becomes +possible to determine how humans evolved. The secret of intelligence +might lie in these genes. It might even be possible to accelerate the path +taken by evolution and even enhance our intelligence. But even fifteen +million base pairs is a huge number to analyze. How can you find a +handful of genetic needles out of this genetic haystack?" +"Dr. Pollard knew that most of our genome is made of “junk DNA” that +does not contain any genes and was largely unaffected by evolution. This +junk DNA slowly mutates at a known rate (roughly 1 percent of it +changes over four million years). Since we differ from the chimps in our +DNA by 1.5 percent, this means that we probably separated from the +chimpanzees about six million years ago. Hence there is a “molecular +clock” in each of our cells. And since evolution accelerates this mutation +rate, analyzing where this acceleration took place allows you to tell +which genes are driving evolution. + +Dr. Pollard reasoned that if she could write a computer program that +could find where most of these accelerated changes are located in our +genome, she could isolate precisely the genes that gave birth to Homo +sapiens. After months of hard work and debugging, she finally placed her +program into the giant computers located at the University of California +at Santa Cruz. Anxiously she awaited the results." +"When the computer printout finally arrived, it showed what she was +looking for: there are 201 regions of our genome showing accelerated +change. But the first one on her list caught her attention. + +“With my mentor David Haussler leaning over my shoulder, I looked +at the top hit, a stretch of 118 bases that together became known as +human accelerated region 1 (HAR1),” she recalled. + + She was ecstatic. Bingo! + +“We had hit the jackpot,” she would write. It was a dream come true. + +She was staring at an area of our genome containing only 118 base +pairs, with the largest divergence of mutations separating us from the + +apes. Of these base pairs, only eighteen mutations were altered since we +became human. Her remarkable discovery showed that a small handful +of mutations could be responsible for raising us from the swamp of our +genetic past." +"Next she and her colleagues tried to decipher the precise nature of this +mysterious cluster called HAR1. They found that HAR1 was remarkably +stable across millions of years of evolution. Primates separated from +chickens about three hundred million years ago, yet only two base pairs +differ between chimps and chickens. So HAR1 was virtually unchanged +for several hundred million years, with only two changes, in the letters G +and C. Yet in just six million years, HAR1 mutated eighteen times, +representing a huge acceleration in our evolution." +"But what was more intriguing was the role HAR1 played in controlling +the overall layout of the cerebral cortex, which is famous for its wrinkled +appearance. A defect in the HAR1 region causes a disorder called +“lissencephaly,” or “smooth brain,” causing the cortex to fold +incorrectly. (Defects in this region are also linked to schizophrenia.) +Besides the large size of our cerebral cortex, one of its main +characteristics is that it is highly wrinkled and convoluted, vastly +increasing its surface area and hence its computational power. Dr. +Pollard’s work showed that changing just eighteen letters in our genome +was partially responsible for one of the major, defining genetic changes +in human history, vastly increasing our intelligence. (Recall that the +brain of Carl Friedrich Gauss, one of the greatest mathematicians in +history, was preserved after his death and showed unusual wrinkling.)" +"Dr. Pollard’s list went even further and identified a few hundred other +areas that also showed accelerated change, some of which were already +known. FOX2, for example, is crucial for the development of speech, +another key characteristic of humans. (Individuals with a defective FOX2 +gene have difficulty making the facial movements necessary for speech.) +Another region called HAR2 gives our fingers the dexterity required to +manipulate delicate tools. + +Furthermore, since the genome of the Neanderthal has been +sequenced, it is possible to compare our genetic makeup with a species +even closer to us than the chimpanzees. (When analyzing the FOX2 gene +in Neanderthals, scientists found that we shared the same gene with + + them. This means that there is a possibility that the Neanderthal could + +vocalize and create speech, as we do.)" +"vocalize and create speech, as we do.) + +Another crucial gene is called ASPM, which is thought to be +responsible for the explosive growth of our brain capacity. Some +scientists believe that this and other genes may reveal why humans +became intelligent but the apes did not. (People with a defective version +of the ASPM gene often suffer from microcephaly, a severe form of +mental retardation, because they have a tiny skull, about the size of one +of our ancestors, Australopithecus.)" +"Scientists have tracked the number of mutations within the ASPM +gene and found that it has mutated about fifteen times in the last five to +six million years, since we separated from the chimpanzee. More recent +mutations in these genes seem to be correlated with milestones in our +evolution. For example, one mutation occurred over one hundred +thousand years ago, when modern humans emerged in Africa, +indistinguishable in appearance from us. And the last mutation was +5,800 years ago, which coincides with the introduction of the written +language and agriculture. + +Because these mutations coincide with periods of rapid growth in +intellect, it is tantalizing to speculate that ASPM is among the handful of +genes responsible for our increased intelligence. If this is true, then +perhaps we can determine whether these genes are still active today, and +whether they will continue to shape human evolution into the future." +"All this research raises a question: Can manipulating a handful of +genes increase our intelligence? + +Quite possibly. + +Scientists are rapidly determining the precise mechanism by which +these genes gave rise to intelligence. In particular, genetic regions and +genes like HAR1 and ASPM could help solve a mystery concerning the +brain. If there are roughly twenty-three thousand genes in your genome, +then how can they possibly control the connections linking one hundred +billion neurons, containing a quadrillion total connections (1 with fifteen +zeros after it)? It seems mathematically impossible. The human genome +is about a trillion times too small to code for all our neural connections. +So our very existence seems to be a mathematical impossibility. + +The answer may be that nature takes numerous shortcuts in creating +the brain. First, many neurons are connected randomly, so that a +detailed blueprint is not necessary, which means that these randomly" +"connected regions organize themselves after a baby is born and starts to +interact with the environment. + +And second, nature also uses modules that repeat themselves over and +over again. Once nature discovers something useful, she often repeats it. +This may explain why only a handful of genetic changes are responsible +for most of our explosive growth in intelligence in the last six million +years. + +Size does matter in this case, then. If we tweak the ASPM and a few +other genes, the brain might become larger and more complex, thereby +making it possible to increase our intelligence. (Increasing our brain size +is not sufficient to do this, since how the brain is organized is also +crucially important. But increasing the gray matter of our brain is a +necessary precondition to increasing our intelligence.) + +APES, GENES, AND GENIUS" +"APES, GENES, AND GENIUS + +Dr. Pollard’s research focused on areas of our genome that we share with +the chimpanzees but that are mutated. It is also possible that there are +areas in our genome found only in humans, independent of the apes. +One such gene was discovered recently, in November 2012. Scientists, +led by a team at the University of Edinburgh, isolated the RIM-941 gene, +which is the only gene ever discovered that is found strictly in Homo +sapiens and not in other primates. Also, geneticists can show that the +gene emerged between one and six million years ago (after the time +when humans and chimpanzees split about six million years ago)." +"Unfortunately, this discovery also set off a huge firestorm in science +newsletters and blogs as misleading headlines blared across the Internet. +Breathless articles appeared claiming that scientists had found a single +gene that could, in principle, make chimpanzees intelligent. The essence +of “humanness” had finally been isolated at the genetic level, the +headlines shouted. + +Reputable scientists soon stepped in and tried to calm things down. In +all likelihood, a series of genes, acting together in complex ways, is +responsible for human intelligence. No single gene can make a chimp +suddenly have human intelligence, they said. + +Although these headlines were highly exaggerated, they did raise a + +serious question: How realistic is Planet of the Apes ?" +"There are a series of complications. If the HAR1 and ASPM genes are +tweaked so that the size and structure of the chimp brain suddenly +expand, then a series of other genes would have to be modified as well. +First, you would have to strengthen the chimp’s neck muscles and +increase its body size to support the larger head. But a large brain would +be useless unless it could control fingers capable of exploiting tools. So +the HAR2 gene would also have to be altered to increase their dexterity. +But since chimps often walk on their hands, another gene would have to +be altered so that the backbone would straighten out and an upright +posture would free up the hands. Intelligence is also useless unless +chimps can communicate with other members of the species. So the +FOX2 gene would also have to be mutated so that humanlike speech +would become possible. And lastly, if you want to create a species of +intelligent apes, you would have to modify the birth canal, since it is not" +"intelligent apes, you would have to modify the birth canal, since it is not +large enough to accommodate the larger skull. You could either perform +caesarians to cut the fetus out or genetically alter the birth canal of the +chimps to accommodate the larger brain." +"After all these necessary genetic adjustments, we are left with a +creature that would look very much like us. In other words, it may be +anatomically impossible to create intelligent apes, as in the movies, +without their also mutating into something closely resembling human +beings. + +Clearly, creating intelligent apes is no simple matter, then. The +intelligent apes we see in Hollywood movies are actually monkey suits +with humans inside, or are computer-generated graphics, so all these +issues are conveniently brushed under the rug. But if scientists could +seriously use gene therapy to create intelligent apes, then they might +closely resemble us, with hands that can use tools, vocal cords that can +create speech, backbones that can support an upright posture, and large +neck muscles to support large heads, as we have." +"All this raises ethical issues as well. Although society may allow +genetic studies of apes, it may not tolerate the manipulation of +intelligent creatures that can feel pain and distress. These creatures, after +all, would be intelligent and articulate enough to complain about their +situation and their fate, and their views would be heard in society. + +Not surprisingly, this area of bioethics is so new that it is totally + +unexplored. The technology is not yet ready, but in the coming decades, +as we identify all the genes and their functions that separate us from the +apes, the treatment of these enhanced animals could become a key +question." +"We can see, therefore, that it is only a matter of time before all the +tiny genetic differences between us and the chimpanzees are carefully +sequenced, analyzed, and interpreted. But this still does not explain a +deeper question: What were the evolutionary forces that gave us this +genetic heritage after we separated from the apes? Why did genes like +ASPM, HAR1, and FOX2 develop in the first place? In other words, +genetics gives us the ability to understand how we became intelligent, +but it does not explain why this happened. + +If we can understand this issue, it might provide clues as to how we +might evolve in the future. This takes us to the heart of the ongoing +debate: What is the origin of intelligence? + +THE ORIGIN OF INTELLIGENCE + +Many theories have been proposed as to why humans developed greater +intelligence, going all the way back to Charles Darwin." +"According to one theory, the evolution of the human brain probably +took place in stages, with the earliest phase initiated by climate change +in Africa. As the weather cooled, the forests began to recede, forcing our +ancestors onto the open plains and savannahs, where they were exposed +to predators and the elements. To survive in this new, hostile +environment, they were forced to hunt and walk upright, which freed up +their hands and opposable thumbs to use tools. This in turn put a +premium on a larger brain to coordinate tool making. According to this +theory, ancient man did not simply make tools—“tools made man.”" +"Our ancestors did not suddenly pick up tools and become intelligent. It +was the other way around. Those humans who picked up tools could +survive in the grasslands, while those who did not gradually died off. +The humans who then survived and thrived in the grasslands were those +who, through mutations, became increasingly adept at tool making, +which required an increasingly larger brain. + +Another theory places a premium on our social, collective nature." +"Another theory places a premium on our social, collective nature. + +Humans can easily coordinate the behavior of over a hundred other +individuals involved in hunting, farming, warring, and building, groups +that are much larger than those found in other primates, which gave +humans an advantage over other animals. It takes a larger brain, +according to this theory, to be able to assess and control the behavior of +so many individuals. (The flip side of this theory is that it took a larger +brain to scheme, plot, deceive, and manipulate other intelligent beings +in your tribe. Individuals who could understand the motives of others + + and then exploit them would have an advantage over those who could +not. This is the Machiavellian theory of intelligence.)" +"Another theory maintains that the development of language, which +came later, helped accelerate the rise of intelligence. With language +comes abstract thought and the ability to plan, organize society, create +maps, etc. Humans have an extensive vocabulary unmatched by any +other animal, with words numbering in the tens of thousands for an +average person. With language, humans could coordinate and focus the +activities of scores of individuals, as well as manipulate abstract +concepts and ideas. Language meant you could manage teams of people +on a hunt, which is a great advantage when pursuing the woolly +mammoth. It meant you could tell others where game was plentiful or +where danger lurked." +"Yet another theory is “sexual selection,” the idea that females prefer to +mate with intelligent males. In the animal kingdom, such as in a wolf +pack, the alpha male holds the pack together by brute force. Any +challenger to the alpha male has to be soundly beaten back by tooth and +claw. But millions of years ago, as humans became gradually more +intelligent, strength alone could not keep the tribe together. Anyone +with cunning and intelligence could ambush, lie or cheat, or form +factions within the tribe to take down the alpha male. Hence the new +generation of alpha males would not necessarily be the strongest. Over +time, the leader would become the most intelligent and cunning. This is +probably the reason why females choose smart males (not necessarily +nerdy smart, but “quarterback smart”). Sexual selection in turn +accelerated our evolution to become intelligent. So in this case the +engine that drove the expansion of our brain would be females who" +"engine that drove the expansion of our brain would be females who +chose men who could strategize, become leaders of the tribe, and outwit +other males, which requires a large brain." +"These are just a few of the theories about the origin of intelligence, +and each has its pros and cons. The common theme seems to be the +ability to simulate the future. For example, the purpose of the leader is +to choose the correct path for the tribe in the future. This means any +leader has to understand the intentions of others in order to plan +strategy for the future. Hence simulating the future was perhaps one of +the driving forces behind the evolution of our large brain and +intelligence. And the person who can best simulate the future is the one +who can plot, scheme, read the minds of many of his fellow tribesmen, +and win the arms race with his fellow man. + +Similarly, language allows you to simulate the future. Animals possess +a rudimentary language, but it is mainly in the present tense. Their +language may warn them of an immediate threat, such as a predator +hiding among the trees. However, animal language apparently has no" +"future or past tense. Animals do not conjugate their verbs. So perhaps +the ability to express the past and future tense was a key breakthrough +in the development of intelligence. + +Dr. Daniel Gilbert, a psychologist at Harvard, writes, “For the first few +hundred million years after their initial appearance on our planet, our +brains were stuck in the permanent present, and most brains still are +today. But not yours and not mine, because two or three million years +ago our ancestors began a great escape from the here and now....” + +THE FUTURE OF EVOLUTION + +So far, we have seen that there are intriguing results indicating that one +can increase one’s memory and intelligence, largely by making the brain +more efficient and maximizing its natural capacity. A variety of methods +are being studied, such as certain drugs, genes, or devices (TES, for +example) that might increase the capabilities of our neurons." +"So the concept of altering the brain size and capacity of the apes is a +distinct, though difficult, possibility. Gene therapy on this scale is still +many decades away. But this raises another difficult question: How far +can this go? Can one extend the intelligence of an organism indefinitely? +Or is there a limit to brain modification imposed by the laws of physics? + +Surprisingly, the answer is yes. The laws of physics put an upper limit + +to what can be done with genetic modification of the human brain, +given certain restraints. To see this limit, it is instructive to first examine +whether evolution is still increasing human intelligence, and then what +can be done to accelerate this natural process." +"In popular culture, there is the notion that evolution will give us big +brains and small, hairless bodies in the future. Likewise, aliens from +space, because they are supposed to possess a superior level of +intelligence, are often portrayed in this fashion. Go to any novelty shop +and you will see the same extraterrestrial face, with big bug eyes, a huge +head, and green skin. + +Actually, there are indications that gross human evolution (i.e., our +basic body shape and intelligence) has largely come to a halt. There are +several factors supporting this. First of all, since we are bipedal +mammals who walk upright, there are limitations to the maximum size +of an infant’s skull that can pass through the birth canal. Second, the rise +of modern technology has removed many of the harsh evolutionary +pressures faced by our ancestors." +"However, evolution on a genetic and molecular basis continues +unabated. Although it’s difficult to see with the naked eye, there is +evidence that human biochemistry has changed to adjust to +environmental challenges, such as combating malaria in tropical areas. +Also, humans recently evolved enzymes to digest lactose sugar as we +learned to domesticate cows and drink milk. Mutations have occurred as +humans adjusted to a diet created by the agricultural revolution. +Moreover, people still choose to mate with others who are healthy and +fit, and so evolution continues to eliminate unsuitable genes at this level. +None of these mutations, however, has changed our basic body plan or +increased our brain size. (Modern technology is also influencing our +evolution to some degree. For example, there is no longer any selection +pressure on nearsighted people, since anyone today can be outfitted with +glasses or contact lenses.) + +PHYSICS OF THE BRAIN" +"PHYSICS OF THE BRAIN + +So from an evolutionary and biological point of view, evolution is no +longer selecting for more intelligent people, at least not as rapidly as it + +did thousands of years ago. + +There are also indications from the laws of physics that we have +reached the maximum natural limit of intelligence, so that any +enhancement of our intelligence would have to come from external +means. Physicists who have studied the neurology of the brain conclude +that there are trade-offs preventing us from getting much smarter. Every +time we envision a brain that is larger, or denser, or more complex, we +bump up against these negative trade-offs." +"The first principle of physics that we can apply to the brain is the +conservation of matter and energy; that is, the law stating that the total +amount of matter and energy in a system remains constant. In particular, +in order to carry out its incredible feats of mental gymnastics, the brain +has to conserve energy, and hence it takes many shortcuts. As we saw in +Chapter 1, what we see with our eyes is actually cobbled together using +energy-saving tricks. It would take too much time and energy for a +thoughtful analysis of every crisis, so the brain saves energy by making +snap judgments in the form of emotions. Forgetting is an alternative way +of saving energy. The conscious brain has access to only a tiny portion of +the memories that have an impact on the brain. + +So the question is: Would increased brain size or density of neurons +give us more intelligence?" +"So the question is: Would increased brain size or density of neurons +give us more intelligence? + + Probably not. “Cortical gray matter neurons are working with axons +that are pretty close to the physical limit,” says Dr. Simon Laughlin of +Cambridge University. There are several ways in which one can increase +the intelligence of the brain using the laws of physics, but each has its +own problems: + +• One can increase brain size and extend the length of neurons. The +problem here is that the brain now consumes more energy. This +generates more heat in the process, which is detrimental to our +survival. If the brain uses up more energy, it gets hotter, and tissue +damage results if the body temperature becomes too high. (The +chemical reactions of the human body and our metabolism require +temperatures to be in a precise range.) Also, longer neurons means +that it takes longer for signals to go across the brain, which slows +down the thinking process." +"• One can pack more neurons into the same space by making them + +thinner. But if neurons become thinner and thinner, the complex +chemical/electrical reactions that must take place inside the axons +fail, and eventually they begin to misfire more easily. Douglas Fox, +writing in Scientific American, says, “You might call it the mother of +all limitations: the proteins that neurons use to generate electrical +pulses, called ion channels, are inherently unstable.” + +• One can increase the speed of the signal by making the neurons +thicker. But this also increases energy consumption and generates +more heat. It also increases the size of the brain, which increases the +time it takes for the signals to reach their destination. + +• One can add more connections between neurons. But this again +increases energy consumption and heat generation, making the +brain larger and slower in the process." +"So each time we tinker with the brain, we are checkmated. The laws +of physics seem to indicate that we have maxed out the intelligence that +we humans can attain in this way. Unless we can suddenly increase the +size of our skulls or the very nature of neurons in our brains, it seems we +are at the maximum level of intelligence. If we are to increase our +intelligence, it has to be done by making our brains more efficient (via +drugs, genes, and possibly TES-type machines). + +PARTING THOUGHTS + +In summary, it may be possible in the coming decades to use a" +"PARTING THOUGHTS + +In summary, it may be possible in the coming decades to use a + + combination of gene therapy, drugs, and magnetic devices to increase +our intelligence. There are several avenues of exploration that are +revealing the secrets of intelligence and how it may be modified or +enhanced. But what would it do to society, though, if we could enhance +our intelligence and get a “brain boost”? Ethicists have seriously +contemplated this question, since the basic science is growing so rapidly. +The big fear is that society may bifurcate, with only the rich and +powerful having access to this technology, which they could use to +further solidify their exalted position in society. Meanwhile, the poor +won’t have access to additional brain power, making it more difficult to +move up in society." +"This is certainly a valid concern, but it flies in the face of the history +of technology. Many of the technologies of the past were indeed initially +the province of the rich and powerful, but eventually mass production, +competition, better transportation, and improvements in technology +drove down the costs, so the average person could afford them. (For +example, we take for granted that we eat foods for breakfast that the +king of England could not have procured a century ago. Technology has +made it possible to purchase delicacies from around the world at any +supermarket that would be the envy of the aristocrats of the Victorian +era.) So if it becomes possible to increase our intelligence, the price of +this technology will gradually fall. Technology is never the monopoly of +the privileged rich. Sooner or later ingenuity, hard work, and simple +market forces will drive down its cost." +"There is also the fear that the human race will split into those who +want their intelligence to be boosted and those who prefer to remain the +same, resulting in the nightmare of having a class of super-intelligent +brahmins lord over the masses of the less gifted. + +But again, perhaps the fear of boosting intelligence has been +exaggerated. The average person has absolutely no interest in being able +to solve the complex tensor equations for a black hole. The average +person sees nothing to gain by mastering the mathematics of +hyperspatial dimensions or the physics of the quantum theory. On the +contrary, the average person may find such activities rather boring and +useless. So most of us are not going to become mathematical geniuses if +given the opportunity, because it is not in our character, and we see +nothing to gain from it." +"Keep in mind that society already has a class of accomplished +mathematicians and physicists, and they are paid significantly less than +ordinary businessmen and wield much less power than average +politicians. Being super smart does not guarantee financial success in +life. In fact, being super smart may actually pigeonhole you in the lower +rungs of a society that values athletes, movie stars, comedians, and + + entertainers more. + +No one ever got rich doing relativity. + +Also, a lot depends on precisely which traits are enhanced. There are +other forms of intelligence besides using mathematics. (Some argue that +intelligence must include artistic genius as well. In this case, one can + +conceivably use this talent to make a comfortable living.)" +"conceivably use this talent to make a comfortable living.) + +Anxious parents of high school children may want to boost the IQ of +their kids as they prepare for standardized exams. But IQ, as we have +seen, does not necessarily correspond to success in life. Likewise, people +may want to enhance their memory, but, as we have seen with savants, +having a photographic memory can be a blessing as well as a curse. And +in both cases, enhancement is unlikely to contribute to a society splitting +in two. + +Society as a whole, however, may benefit from this technology. +Workers with an enhanced intelligence would be better prepared to face +an ever-changing job market. Retraining workers for the jobs of the +future would be less of a drain on society. Furthermore, the public will +be able to make informed decisions about major technological issues of +the future (e.g., climate change, nuclear energy, space exploration) +because they will grasp these complex issues better." +"Also, this technology may help even out the playing field. Children +today who go to exclusive private schools and have personal tutors are +better prepared for the job market because they have more opportunities +to master difficult materials. But if everyone has had their intelligence +enhanced, the fault lines within society will be evened out. Then how far +someone goes in life would be more related to their drive, ambition, +imagination, and resourcefulness rather than to being born with a silver +spoon in their mouth. + +In addition, raising our intelligence may help speed up technological +innovation. Increased intelligence would mean a greater ability to +simulate the future, which would be invaluable in making scientific +discoveries. Often, science stagnates in certain areas because of a lack of +fresh new ideas to stimulate new avenues of research. Having an ability +to simulate different possible futures would vastly increase the rate of +scientific breakthroughs." +"These scientific discoveries, in turn, could generate new industries, +which could enrich all of society, creating new markets, new jobs, and +new opportunities. History is full of technological breakthroughs +creating entirely new industries that benefited not just the few, but all of + + society (think of the transistor and the laser, which today form the +foundation of the world economy). + +However, in science fiction, there is the recurring theme of the super + +criminal, who uses his superior brain power to embark on a crime spree +and thwart the superhero. Every Superman has his Lex Luthor, every +Spider-Man has his Green Goblin. Although it is certainly possible that a +criminal mind will use a brain booster to create super weapons and plan +the crime of the century, realize that members of the police force can +also have their intelligence boosted to outwit the evil mastermind. So +super criminals are dangerous only if they are the only ones in +possession of enhanced intelligence." +"So far, we have examined the possibility that we can enhance or alter +our mental capabilities via telepathy, telekinesis, uploading memories, +or brain boosts. Such enhancement basically means modifying and +augmenting the mental capabilities of our consciousness. This tacitly +assumes that our normal consciousness is the only one, but I’d like to +explore whether there are different forms of consciousness. If so, there +could be other ways of thinking that lead to totally different outcomes +and consequences. Within our own thoughts, there are altered states of +consciousness, such as dreams, drug-induced hallucinations, and mental +illness. There is also nonhuman consciousness, the consciousness of +robots, and even that of aliens from outer space. We have to give up the +chauvinistic notion that our human consciousness is the only one. There +is more than one way to create a model of our world, and more than one +way to simulate its future." +"Dreams, for example, are one of the most ancient forms of +consciousness and were studied by the ancients, yet very little progress +has been made in understanding them until recently. Perhaps dreams are +not silly, random events spliced together by the sleeping brain but +phenomena that may give insight into the meaning of consciousness. +Dreams may be a key to understanding altered states of consciousness. + +BOOK III ALTEHED CONSCIOUSNESS + +The future belongs to those who believe in the beauty of their +dreams. + +—ELEANOR ROOSEVELT + + 7 IN YOUR DREAMS + +Dreams can determine destiny." +"—ELEANOR ROOSEVELT + + 7 IN YOUR DREAMS + +Dreams can determine destiny. + +Perhaps the most famous dream in antiquity took place in the year +A.D. 312, when the Roman emperor Constantine engaged in one of the +greatest battles of his life. Faced with a rival army twice the size of his +own, he realized that he probably would die in battle the next day. But +in a dream he had that night, an angel appeared before him bearing the +image of a cross, uttering the fateful words “By this symbol, you shall +conquer.” Immediately he ordered the shields of his troops adorned with +the symbol of the cross." +"History records that he emerged triumphant the next day, cementing +his hold on the Roman Empire. He vowed to repay the blood debt to this +relatively obscure religion, Christianity, that had been persecuted for +centuries by previous Roman emperors and whose adherents were +regularly fed to the lions in the Colosseum. He signed laws that would +eventually pave the way for it to become an official religion of one of +the greatest empires in the world." +"For thousands of years, kings and queens, as well as beggars and +thieves, have all wondered about dreams. The ancients considered +dreams to be omens about the future, so there have been countless +attempts throughout history to interpret them. The Bible records in +Genesis 41 the rise of Joseph, who was able to correctly interpret the +dreams of the Pharaoh of Egypt thousands of years ago. When the +Pharaoh dreamed about seven fat cows, followed by seven lean cows, he +was so disturbed by the imagery that he asked scribes and mystics +throughout the kingdom to find its meaning. All failed to give a +convincing explanation, until Joseph finally interpreted the dream to +mean that Egypt would have seven years of good harvests, followed by +seven years of drought and famine. So, said Joseph, Egypt must begin +stockpiling grain and supplies now, in preparation for the coming years +of want and desperation. When this came to pass, Joseph was considered + +to be a prophet." +"to be a prophet. + +Dreams have long been associated with prophesy, but in more recent +times they’ve also been known to stimulate scientific discovery. The idea +that neurotransmitters could facilitate the movement of information past +a synapse, which forms the foundation of neuroscience, came to +pharmacologist Otto Loewi in a dream. Similarly, in 1865, August +Kekule had a dream about benzene, in which the bonds of carbon atoms +formed a chain that eventually wrapped around and finally formed a + + circle, just like a snake biting its tail. This dream would unlock the +atomic structure of the benzene molecule. He concluded, “Let us learn to +dream!”" +"Dreams have also been interpreted as a window onto our true +thoughts and intentions. The great Renaissance writer and essayist +Michel de Montaigne once wrote, “I believe it to be true that dreams are +the true interpretations of our inclinations, but there is art required to +sort and understand them.” More recently, Sigmund Freud proposed a +theory to explain the origin of dreams. In his signature work, The +Interpretation of Dreams, he claimed that they were manifestations of our +subconscious desires, which were often repressed by the waking mind +but which run wild every night. Dreams were not just the random +figments of our overheated imaginations but could actually uncover +deep secrets and truths about ourselves. “Dreams are the royal road to +the unconscious,” he wrote. Since then, people have amassed huge +encyclopedias that claim to reveal the hidden meaning behind every +disturbing image in terms of Freudian theory." +"Hollywood takes advantage of our continuing fascination with dreams. +A favorite scene in many movies is when the hero experiences a +terrifying dream sequence and then suddenly wakes up from the +nightmare in a cold sweat. In the blockbuster movie Inception, Leonardo +DiCaprio plays a petty thief who steals intimate secrets from the most +unlikely of all places, people’s dreams. With a new invention, he is able +to enter people’s dreams and deceive them into giving up their financial +secrets. Corporations spend millions of dollars protecting industrial +secrets and patents. Billionaires jealously guard their wealth using +elaborate codes. His job is to steal them. The plot quickly escalates as +the characters enter dreams in which a person falls asleep and dreams +again. So these criminals descend deeper and deeper into multiple layers + +of the subconscious." +"of the subconscious. + +But although dreams have always haunted and mystified us, only in +the last decade or so have scientists been able to peel away the mysteries +of dreams. In fact, scientists can now do something once considered +impossible: they are able to take rough photographs and videotapes of +dreams with MRI machines. One day, you may be able to view a video of +the dream you had the previous night and gain insight into your own +subconscious mind. With proper training, you might be able to +consciously control the nature of your dreams. And perhaps, like +DiCaprio’s character, with advanced technology you might even be able +to enter someone else’s dream. + +THE NATURE OF DREAMS" +"THE NATURE OF DREAMS + + As mysterious as they are, dreams are not a superfluous luxury, the +useless ruminations of the idle brain. Dreams, in fact, are essential for +survival. Using brain scans, it is possible to show that certain animals +exhibit dreamlike brain activity. If deprived of dreams, these animals +would often die faster than they would by starvation, because such +deprivation severely disrupts their metabolism. Unfortunately, science +does not know exactly why this is the case. + +Dreaming is an essential feature of our sleep cycle as well. We spend +roughly two hours a night dreaming when we sleep, with each dream +lasting five to twenty minutes. In fact, we spend about six years +dreaming during an average lifetime." +"Dreams are also universal across the human race. Looking across +different cultures, scientists find common themes in dreams. Fifty +thousand dreams were recorded over a forty-year time period by +psychology professor Calvin Hall. He followed this up with one thousand +dream reports from college students. Not surprisingly, he found that +most people dreamed of the same things, such as personal experiences +from the previous days or week. (However, animals apparently dream +differently than we do. In the dolphin, for example, only one hemisphere +at a time sleeps in order to prevent drowning, because they are air- +breathing mammals, not fish. So if they dream, it is probably in only one +hemisphere at a time.)" +"The brain, as we have seen, is not a digital computer, but rather a +neural network of some sort that constantly rewires itself after learning +new tasks. Scientists who work with neural networks noticed something +interesting, though. Often these systems would become saturated after +learning too much, and instead of processing more information they +would enter a “dream” state, whereby random memories would +sometimes drift and join together as the neural networks tried to digest +all the new material. Dreams, then, might reflect “house cleaning,” in +which the brain tries to organize its memories in a more coherent way. +(If this is true, then possibly all neural networks, including all organisms +that can learn, might enter a dream state in order to sort out their +memories. So dreams probably serve a purpose. Some scientists have +speculated that this might imply that robots that learn from experience +might also eventually dream as well.)" +"Neurological studies seem to back up this conclusion. Studies have +shown that retaining memories can be improved by getting sufficient +sleep between the time of activity and a test. Neuroimaging shows that +the areas of the brain that are activated during sleep are the same as +those involved in learning a new task. Dreaming is perhaps useful in + + consolidating this new information. + +Also, some dreams can incorporate events that happened a few hours +earlier, just before sleep. But dreams mostly incorporate memories that +are a few days old. For example, experiments have shown that if you put +rose-colored glasses on a person, it takes a few days before the dreams +become rose-colored as well. + +BRAIN SCANS OF DREAMS" +"BRAIN SCANS OF DREAMS + +Brain scans are now unveiling some of the mystery of dreams. Normally +EEG scans show that the brain is emitting steady electromagnetic waves +while we are awake. However, as we gradually fall asleep, our EEG +signals begin to change frequency. When we finally dream, waves of +electrical energy emanate from the brain stem that surge upward, rising +into the cortical areas of the brain, especially the visual cortex. This +confirms that visual images are an important component of dreams. +Finally, we enter a dream state, and our brain waves are typified by + +rapid eye movements (REM). (Since some mammals also enter REM +sleep, we can infer that they might dream as well.)" +"While the visual areas of the brain are active, other areas involved +with smell, taste, and touch are largely shut down. Almost all the images +and sensations processed by the body are self-generated, originating +from the electromagnetic vibrations from our brain stem, not from +external stimuli. The body is largely isolated from the outside world. +Also, when we dream, we are more or less paralyzed. (Perhaps this +paralysis is to prevent us from physically acting out our dreams, which +could be disastrous. About 6 percent of people suffer from “sleep +paralysis” disorder, in which they wake up from a dream still paralyzed. +Often these individuals wake up frightened and believing that there are +creatures pinning down their chest, arms, and legs. There are paintings +from the Victorian era of women waking up with a terrifying goblin +sitting on their chest glaring down at them. Some psychologists believe +that sleep paralysis could explain the origin of the alien abduction +syndrome.)" +"The hippocampus is active when we dream, suggesting that dreams +draw upon our storehouse of memories. The amygdala and anterior +cingulate are also active, meaning that dreams can be highly emotional, +often involving fear. + +But more revealing are the areas of the brain that are shut down, +including the dorsolateral prefrontal cortex (which is the command + + center of the brain), the orbitofrontal cortex (which can act like a censor +or fact-checker), and the temporoparietal region (which processes +sensory motor signals and spatial awareness)." +"When the dorsolateral prefrontal cortex is shut down, we can’t count +on the rational, planning center of the brain. Instead, we drift aimlessly +in our dreams, with the visual center giving us images without rational +control. The orbitofrontal cortex, or the fact-checker, is also inactive. +Hence dreams are allowed to blissfully evolve without any constraints +from the laws of physics or common sense. And the temporoparietal +lobe, which helps coordinate our sense of where we are located using +signals from our eyes and inner ear, is also shut down, which may +explain our out-of-body experiences while we dream. + +As we have emphasized, human consciousness mainly represents the +brain constantly creating models of the outside world and simulating + +them into the future. If so, then dreams represent an alternate way in +which the future is simulated, one in which the laws of nature and social +interactions are temporarily suspended. + +HOW DO WE DREAM?" +"HOW DO WE DREAM? + +But that leaves open this question: What generates our dreams? One of +the world’s authorities on dreams is Dr. Allan Hobson, a psychiatrist at +Harvard Medical School. He has devoted decades of his life to unveiling +the secrets of dreams. He claims that dreams, especially REM sleep, can +be studied at the neurological level, and that dreams arise when the +brain tries to make sense of the largely random signals emanating from +the brain stem. + +When I interviewed him, he told me that after many decades of +cataloging dreams, he found five basic characteristics: + +1. Intense emotions—this is due to the activation of the amygdala, +causing emotions such as fear. + +2. Illogical content—dreams can rapidly shift from one scene to +another, in defiance of logic. + +3. Apparent sensory impressions—dreams give us false sensations that +are internally generated. + +4. Uncritical acceptance of dream events—we uncritically accept the +illogical nature of the dream." +"5. Difficulty in being remembered—dreams are soon forgotten, within +minutes of waking up. + +Dr. Hobson (with Dr. Robert McCarley) made history by proposing the +first serious challenge to Freud’s theory of dreams, called the “activation +synthesis theory.” In 1977, they proposed the idea that dreams originate +from random neural firings in the brain stem, which travel up to the +cortex, which then tries to make sense of these random signals. + +The key to dreams lies in nodes found in the brain stem, the oldest +part of the brain, which squirts out special chemicals, called adrenergics, +that keep us alert. As we go to sleep, the brain stem activates another + +system, the cholinergic, which emits chemicals that put us in a dream +state." +"system, the cholinergic, which emits chemicals that put us in a dream +state. + +As we dream, cholinergic neurons in the brain stem begin to fire, +setting off erratic pulses of electrical energy called PGO (pontine- +geniculate-occipital) waves. These waves travel up the brain stem into +the visual cortex, stimulating it to create dreams. Cells in the visual +cortex begin to resonate hundreds of times per second in an irregular +fashion, which is perhaps responsible for the sometimes incoherent +nature of dreams. + +This system also emits chemicals that decouple parts of the brain +involved with reason and logic. The lack of checks coming from the +prefrontal and orbitofrontal cortices, along with the brain becoming +extremely sensitive to stray thoughts, may account for the bizarre, +erratic nature of dreams." +"Studies have shown that it is possible to enter the cholinergic state +without sleep. Dr. Edgar Garcia-Rill of the University of Arkansas claims +that meditation, worrying, or being placed in an isolation tank can +induce this cholinergic state. Pilots and drivers facing the monotony of a +blank windshield for many hours may also enter this state. In his +research, he has found that schizophrenics have an unusually large +number of cholinergic neurons in their brain stem, which may explain +some of their hallucinations. + +To make his studies more efficient, Dr. Allan Hobson had his subjects +put on a special nightcap that can automatically record data during a +dream. One sensor connected to the nightcap registers the movements of +a person’s head (because head movements usually occur when dreams +end). Another sensor measures movements of the eyelids (because REM +sleep causes eyelids to move). When his subjects wake up, they +immediately record what they dreamed about, and the information from" +"the nightcap is fed into a computer. + +In this way, Dr. Hobson has accumulated a vast amount of information +about dreams. So what is the meaning of dreams? I asked him. He +dismisses what he calls the “mystique of fortune-cookie dream +interpretation.” He does not see any hidden message from the cosmos in +dreams. + +Instead, he believes that after the PGO waves surge from the brain +stem into the cortical areas, the cortex is trying to make sense of these + +erratic signals and winds up creating a narrative out of them: a dream. + +PHOTOGRAPHING A DREAM" +"erratic signals and winds up creating a narrative out of them: a dream. + +PHOTOGRAPHING A DREAM + +In the past, most scientists avoided the study of dreams, since they are so +subjective and have such a long historical association with mystics and +psychics. But with MRI scans, dreams are now revealing their secrets. In +fact, since the brain centers that control dreaming are nearly identical to +the ones that control vision, it is therefore possible to photograph a +dream. This pioneering work is being done in Kyoto, Japan, by scientists +at the ATR Computational and Neuroscience Laboratories." +"Subjects are first placed in an MRI machine and shown four hundred +black-and-white images, each consisting of a set of dots within a ten-by- +ten-pixel framework. One picture is flashed at a time, and the MRI +records how the brain responds to each collection of pixels. As with +other groups working in this field of BMI, the scientists eventually create +an encyclopedia of images, with each image of pixels corresponding to a +specific MRI pattern. Here the scientists are able to work backward, to +correctly reconstruct self-generated images from MRI brain scans taken +while the subject dreams. + +ATR chief scientist Yukiyasu Kamitani says, “This technology can also +be applied to senses other than vision. In the future, it may also be +possible to read feelings and complicated emotional states.” In fact, any +mental state of the brain might be imaged in this way, including dreams, +as long as a one-to-one map can be made between a certain mental state +and an MRI scan." +"The Kyoto scientists have concentrated on analyzing still photographs +generated by the mind. In Chapter 3, we encountered a similar approach +pioneered by Dr. Jack Gallant, in which the voxels from 3-D MRI scans +of the brain can be used to reconstruct the actual image seen by the eye +with the help of a complex formula. A similar process has allowed Dr. + + Gallant and his team to create a crude video of a dream. When I visited +the laboratory in Berkeley, I talked to a postdoctoral staff member, Dr. +Shinji Nishimoto, who allowed me to watch the video of one of his +dreams, one of the first ever done. I saw a series of faces flickering +across the computer screen, meaning that the subject (in this case Dr." +"Nishimoto himself) was dreaming of people, rather than animals or +objects. This was amazing. Unfortunately, the technology is not yet good +enough to see the precise facial features of the people appearing in his +dream, so the next step is to increase the number of pixels so that more +complex images can be identified. Another advance will be to reproduce +images in color rather than black and white. + +I then asked Dr. Nishimoto the crucial question: How do you know the +video is accurate? How do you know that the machine isn’t just making +things up? He was a bit sheepish when he replied that this was a weak +point in his research. Normally, you have only a few minutes after +waking up to record a dream. After that, most dreams are lost in the fog +of our consciousness, so it is not easy to verify the results." +"Dr. Gallant told me that this research on videotaping dreams was still +a work in progress, and that is why it’s not ready for publication. There +is still a ways to go before we can watch a videotape of last night’s +dream. + +LUCID DREAMS + +Scientists are also investigating a form of dreaming that was once +thought to be a myth: lucid dreaming, or dreaming while you are +conscious. This sounds like a contradiction in terms, but it has been +verified in brain scans. In lucid dreaming, dreamers are aware that they +are dreaming and can consciously control the direction of the dream. +Although science has only recently begun to experiment with lucid +dreaming, there are references to this phenomenon dating back +centuries. In Buddhism, for example, there are books that refer to lucid +dreamers and how to train yourself to become one. Over the centuries, +several people in Europe have written detailed accounts of their lucid +dreams." +"Brain scans of lucid dreamers show that this phenomenon is real; +during REM sleep, their dorsolateral prefrontal cortex, which is usually +dormant when a normal person dreams, is active, indicating that the +person is partially conscious while dreaming. In fact, the more lucid the +dream, the more active the dorsolateral prefrontal cortex. Since the +dorsolateral prefrontal cortex represents the conscious part of the brain, + + the dreamer must be aware while he or she is dreaming." +"the dreamer must be aware while he or she is dreaming. + +Dr. Hobson told me that anyone can learn to do lucid dreaming by +practicing certain techniques. In particular, people who do lucid +dreaming should keep a notebook of dreams. Before going to sleep, they +should remind themselves that they will “wake up” in the middle of the +dream and realize that they are moving in a dream world. It is important +to have this frame of mind before hitting the pillow. Since the body is +largely paralyzed during REM sleep, it is difficult for the dreaming +person to send a signal to the outside world that he has entered a dream, +but Dr. Stephen LaBerge at Stanford University has studied lucid +dreamers (including himself) who can signal the outside world while +dreaming." +"In 2011, for the first time, scientists used MRI and EEG sensors to +measure dream content and even make contact with a dreaming person. +At the Max Planck Institute in Munich and Leipzig, scientists enlisted the +help of lucid dreamers, who were fitted with EEG sensors on their heads +to help the scientists determine the moment they entered REM sleep; +they were then placed in an MRI machine. Before falling asleep, the +dreamers agreed to initiate a set of eye movements and breathing +patterns when dreaming, like a Morse code. They were told that once +they started dreaming, they should clench their right fist and then their +left one for ten seconds. That was the signal that they were dreaming." +"The scientists found that, once the subjects entered their dream state, +the sensorimotor cortex of the brain (responsible for controlling motor +actions like clenching your fists) was activated. The MRI scans could +pick up that the fists were being clenched and which fist was being +clenched first. Then, using another sensor (a near-infrared spectrometer) +they were able to confirm that there was increased brain activity in the +region that controls the planning of movements. + +“Our dreams are therefore not a ‘sleep cinema’ in which we merely +observe an event passively, but involve activity in the regions of the +brain that are relevant to the dream content,” says Michael Czisch, a +group leader at the Max Planck Institute. + +ENTERING A DREAM + +If we can communicate with a dreaming person, then is it also possible +to alter someone’s dream from the outside? Quite possibly. + +First, as we have seen, scientists have already made the initial steps in" +"First, as we have seen, scientists have already made the initial steps in + + videotaping a person’s dream, and in the coming years, it should be +possible to create much more accurate pictures and videos of dreams. +Since scientists have already been able to establish a communication link +between the real world and the lucid dreamer in the fantasy world, then, +in principle, scientists should be able to deliberately alter the course of a +dream. Let’s say that scientists are viewing the video of a dream using an +MRI machine as the dream unfolds in real time. As the person wanders +around the dreamscape, the scientists can tell where he is going and give +directions for him to move in different ways. + +So in the near future, it might be possible to watch a video of a +person’s dream and actually influence its general direction. But in the +movie Inception, Leonardo DiCaprio goes much further. He is able not +only to watch another person’s dream, but also to enter it. Is this +possible?" +"We saw earlier that we are paralyzed when we dream so that we don’t +carry out our dream fantasies, which might be disastrous. However, +when people are sleepwalking, they often have their eyes open (although +their eyes look glazed over). So sleepwalkers live in a hybrid world, part +real and part dreamlike. There are many documented instances of people +walking around their homes, driving cars, cutting wood, and even +committing homicides while in this dream state, where reality and the +fantasy world are mixed. Hence it is possible that physical images that +the eye actually sees can freely interact with the fictitious images that +the brain is concocting during a dream." +"The way to enter someone’s dream, then, might be to have the subject +wear contact lenses that can project images directly onto their retinas. +Already, prototypes of Internet contact lenses are being developed at the +University of Washington in Seattle. So if the observer wanted to enter +the subject’s dream, first he would sit in a studio and have a video +camera film him. His image could then be projected onto the contact +lenses of the dreamer, creating a composite image (the image of the +observer superimposed upon the imaginary image the brain is +manufacturing). + +The observer could actually see this dream world as he wanders + +around the dream, since he, too, would be wearing Internet contact +lenses. The MRI image of the subject’s dream, after it has been +deciphered by computer, would be sent directly into the observer’s +contact lenses." +"Furthermore, you could actually change the direction of the dream +you have entered. As you walk around in the empty studio, you would +see the dream unfold in your contact lens, so you could start to interact + + with the objects and people appearing in the dream. This would be quite +an experience, since the background would change without warning, +images would appear and disappear without reason, and the laws of +physics would be suspended. Anything goes." +"Further into the future, it might even be possible to enter another +person’s dream by directly connecting two sleeping brains. Each brain +would have to be connected to MRI scanners that were connected to a +central computer, which would merge the two dreams into a single one. +The computer would first decipher each person’s MRI scans into a video +image. Then the dream of one person would be sent into the sensory +areas of the other person’s brain, so that the other dreamer’s dream +would merge with the first dreamer’s dream. However, the technology of +videotaping and interpreting dreams would have to become much more +advanced before this could become a possibility." +"But this raises another question: If it’s possible to alter the course of +someone’s dream, is it possible to control not only that person’s dream +but that person’s mind as well? During the Cold War, this became a +serious issue as both the Soviet Union and the United States played a +deadly game, trying to use psychological techniques to control other +people’s wills. + +Minds are simply what brains do. + +—MARVIN MINSKY + +8 CAN THE MIND BE CONTROLLED?" +"Minds are simply what brains do. + +—MARVIN MINSKY + +8 CAN THE MIND BE CONTROLLED? + +A raging bull is released into an empty arena in Cordoba, Spain. For +generations, this ferocious beast has been carefully bred to maximize its +killer instinct. Then a Yale professor calmly enters the same arena. +Rather than donning a tweed jacket, he is dressed like a dashing +matador, wearing a bright golden jacket and waving a red cape defiantly +in front of the bull, egging him on. Instead of running away in terror, the +professor looks calm, confident, and even detached. To a bystander, it +appears as if the professor has gone mad and wants to commit suicide." +"Enraged, the bull locks onto the professor. Suddenly the bull charges, +aiming his deadly horns at him. The professor does not run away in fear. +Instead, he holds a small box in his hand. Then, in front of the cameras, +he presses a button on the box, and the bull stops dead in his tracks. The +professor is so confident of himself that he has risked his life to prove a +point, that he has mastered the art of controlling the mind of a mad bull. + + The Yale professor is Dr. Jose Delgado, who was years ahead of his +time. He pioneered a series of remarkable but unsettling animal +experiments in the 1960s, in which he put electrodes into their brains +with the aim of trying to control their movement. To stop the bull, he +inserted electrodes into the striatum of the basal ganglia at the base of +the brain, which is involved with motor coordination." +"He also did a series of other experiments on monkeys to see if he could +rearrange their social hierarchy with the push of a button. After +implanting electrodes into the caudate nucleus (a region associated with +motor control) of the alpha male within the group, Delgado could reduce +the aggressive tendencies of the leader on command. Without threats of +retaliation, the delta males began to assert themselves, taking over the +territory and privileges normally reserved for the alpha male. The alpha +male, meanwhile, appeared to have lost interest in defending his +territory. + +Then Dr. Delgado pressed another button, and the alpha male + +instantly sprung back to normal, resuming his aggressive behavior and +reestablishing his power as the king of the hill. The delta males +scrambled in fear. + +Dr. Delgado was the first person in history to show that it was possible +to control the minds of animals in this way. The professor became the +puppet master, pulling the strings of living puppets." +"As expected, the scientific community looked at Dr. Delgado’s work +with unease. To make matters worse, he wrote a book in 1969 with the +provocative title Physical Control of the Mind: Toward a Psychocivilized +Society. It raised an unsettling question: If scientists like Dr. Delgado are +pulling the strings, then who controls the puppet master?" +"Dr. Delgado’s work puts into sharp focus the enormous promise and +perils of this technology. In the hands of an unscrupulous dictator, this +technology might be used to deceive and control his unfortunate +subjects. But it can also be used to free millions of people who are +trapped in mental illness, hounded by their hallucinations, or crushed by +their anxieties. (Years later, Dr. Delgado was asked by a journalist why +he initiated these controversial experiments. He said that he wanted to +correct the horrendous abuses being suffered by the mentally ill. They +often underwent radical lobotomies, in which the prefrontal cortex was +scrambled by a knife resembling an ice pick, which was hammered into +the brain above the eye socket. The results were often tragic, and some +of the horrors were exposed in Ken Kesey’s novel One Flew Over the +Cuckoo’s Nest, which was made into a movie with Jack Nicholson. Some" +"patients became calm and relaxed, but many others became zombies: +lethargic, indifferent to pain and feelings, and emotionally vacuous. The +practice was so widespread that in 1949, Antonio Moniz won the Nobel +Prize for perfecting the lobotomy. Ironically, in 1950, the Soviet Union +banned this technology, stating that “it was contrary to the principles of +humanity.” Lobotomies, the Soviet Union charged, turned “an insane +person into an idiot.” In total, it is estimated that forty thousand +lobotomies were performed in the United States alone over two +decades.) + +MIND CONTROL AND THE COLD WAR + +Another reason for the chilly reception of Dr. Delgado’s work was the +political climate of the time. It was the height of the Cold War, with +painful memories of captured U.S. soldiers being paraded in front of +cameras during the Korean War. With blank stares, they would admit +they were on secret spy missions, confess to horrific war crimes, and +denounce U.S. imperialism." +"To make sense of this, the press used the term “brainwashing,” the +idea that the communists had developed secret drugs and techniques to +turn U.S. soldiers into pliable zombies. In this charged political climate, +Frank Sinatra starred in the 1962 Cold War thriller The Manchurian +Candidate, in which he tries to expose a secret communist “sleeper” +agent whose mission is to assassinate the president of the United States. +But there is a twist. The assassin is actually a trusted U.S. war hero, +someone who was captured and then brainwashed by the communists. +Coming from a well-connected family, the agent seems above suspicion +and is almost impossible to stop. The Manchurian Candidate mirrored the +anxieties of many Americans at that time." +"Many of these fears were also stoked by Aldous Huxley’s prophetic +1931 novel Brave New World. In this dystopia, there are large test-tube- +baby factories that produce clones. By selectively depriving oxygen from +these fetuses, it is possible to produce children of different levels of brain +damage. At the top are the alphas, who suffer no brain damage and are +bred to rule society. At the bottom are the epsilons, who suffer +significant brain damage and are used as disposable, obedient workers. +In between are additional levels made up of other workers and the +bureaucracy. The elite then control society by flooding it with mind- +altering drugs, free love, and constant brainwashing. In this way, peace, +tranquility, and harmony are maintained, but the novel asked a +disturbing question that resonates even today: How much of our freedom +and basic humanity do we want to sacrifice in the name of peace and +social order? + + CIA MIND-CONTROL EXPERIMENTS" +"CIA MIND-CONTROL EXPERIMENTS + +The Cold War hysteria eventually reached the highest levels of the CIA. +Convinced that the Soviets were far ahead in the science of brainwashing + +and unorthodox scientific methods, the CIA embarked upon a variety of +classified projects, such as MKULTRA, which began in 1953, to explore +bizarre, fringe ideas. (In 1973, as the Watergate scandal spread panic +throughout the government, CIA director Richard Helms canceled +MKULTRA and hurriedly ordered all documents pertaining to the project +destroyed. However, a cache of twenty thousand documents somehow +survived the purge and were declassified in 1977 under the Freedom of +Information Act, revealing the full scope of this massive effort.)" +"It is now known that, from 1953 to 1973, MULTRA funded 80 +institutions, including 44 universities and colleges, and scores of +hospitals, pharmaceutical companies, and prisons, often experimenting +on unsuspecting people without their permission, in 150 secret +operations. At one point, fully 6 percent of the entire CIA budget went +into MKULTRA. + +Some of these mind-control projects included: + +• developing a “truth serum” so prisoners would spill their secrets + +• erasing memories via a U.S. Navy project called “Subproject 54” + +• using hypnosis and a wide variety of drugs, especially LSD, to +control behavior + +• investigating the use of mind-control drugs against foreign leaders, +e.g., Fidel Castro + +• perfecting a variety of interrogation methods against prisoners + +• developing a knockout drug that was fast working and left no trace + +• altering people’s personality via drugs to make them more pliable" +"• altering people’s personality via drugs to make them more pliable + +Although some scientists questioned the validity of these studies, +others went along willingly. People from a wide range of disciplines +were recruited, including psychics, physicists, and computer scientists, to +investigate a variety of unorthodox projects: experimenting with mind- +altering drugs such as LSD, asking psychics to locate the position of +Soviet submarines patrolling the deep oceans, etc. In one sad incident, a + + U.S. Army scientist was secretly given LSD. According to some reports, +he became so violently disoriented that he committed suicide by +jumping out a window." +"Most of these experiments were justified on the grounds that the +Soviets were already ahead of us in terms of mind control. The U.S. +Senate was briefed in another secret report that the Soviets were +experimenting with beaming microwave radiation directly into the +brains of test subjects. Rather than denouncing the act, the United States +saw “great potential for development into a system for disorienting or +disrupting the behavior pattern of military or diplomatic personnel.” The +U.S. Army even claimed that it might be able to beam entire words and +speeches into the minds of the enemy: “One decoy and deception +concept ... is to remotely create noise in the heads of personnel by +exposing them to low power, pulsed microwaves.... By proper choice of +pulse characteristics, intelligible speech may be created.... Thus, it may +be possible to ‘talk’ to selected adversaries in a fashion that would be +most disturbing to them,” the report said." +"Unfortunately, none of these experiments was peer-reviewed, so +millions of taxpayer dollars were spent on projects like this one, which +most likely violated the laws of physics, since the human brain cannot +receive microwave radiation and, more important, does not have the +ability to decode microwave messages. Dr. Steve Rose, a biologist at the +Open University, has called this far-fetched scheme a “neuro-scientific +impossibility.” + +But for all the millions of dollars spent on these “black projects,” +apparently not a single piece of reliable science emerged. The use of +mind-altering drugs did, in fact, create disorientation and even panic +among the subjects who were tested, but the Pentagon failed to +accomplish the key goal: control of the conscious mind of another +person." +"Also, according to psychologist Robert Jay Lifton, brainwashing by the +communists had little long-term effect. Most of the American troops who +denounced the United States during the Korean War reverted back to +their normal personalities soon after being released. In addition, studies +done on people who have been brainwashed by certain cults also show +that they revert back to their normal personality after leaving the cult. +So it seems that, in the long run, one’s basic personality is not affected +by brainwashing. + +Of course, the military was not the first to experiment with mind +control. In ancient times, sorcerers and seers would claim that giving + + magic potions to captured soldiers would make them talk or turn against +their leaders. One of the earliest of these mind-control methods was +hypnotism. + +YOU ARE GETTING SLEEPY...." +"YOU ARE GETTING SLEEPY.... + +As a child, I remember seeing TV specials devoted to hypnosis. In one +show, a person was placed in a hypnotic trance and told that when he +woke up, he would be a chicken. The audience gasped as he began to +cluck and flap his arms around the stage. As dramatic as this +demonstration was, it’s simply an example of “stage hypnosis.” Books +written by professional magicians and showmen explain that they use +shills planted in the audience, the power of suggestion, and even the +willingness of the victim to play along with the ruse. + +I once hosted a BBC/Discovery TV documentary called Time, and the +subject of long-lost memories came up. Is it possible to evoke such +distant memories through hypnosis? And if it is, can you then impose +your will on another? To test some of these ideas, I had myself +hypnotized for TV." +"BBC hired a skilled professional hypnotist to begin the process. I was +asked to lie down on a bed in a quiet, darkened room. The hypnotist +spoke to me in slow, gentle tones, gradually making me relax. After a +while, he asked me to think back into the past, to perhaps a certain place +or incident that stood out even after all these years. And then he asked +me to reenter that place, reexperiencing its sights, sounds, and smells. +Remarkably, I did begin to see places and people’s faces that I had +forgotten about decades ago. It was like watching a blurred movie that +was slowly coming into focus. But then the recollections stopped. At a +certain point, I could not recapture any more memories. There was +clearly a limit to what hypnosis could do." +"EEG and MRI scans show that during hypnosis the subject has minimal +sensory stimulation in the sensory cortices from the outside. In this way, +hypnosis can allow one to access some memories that are buried, but it +certainly cannot change one’s personality, goals, or wishes. A secret +1966 Pentagon document corroborates this, explaining that hypnotism +cannot be trusted as a military weapon. “It is probably significant that in + +the long history of hypnosis, where the potential application to +intelligence has always been known, there are no reliable accounts of its +effective use by an intelligence service,” it read." +"It should also be noted that brain scans show that hypnotism is not a +new state of consciousness, like dreaming and REM sleep. If we define +human consciousness as the process of continually building models of +the outside world and then simulating how they evolve into the future to +carry out a goal, we see that hypnosis cannot alter this basic process. +Hypnosis can accentuate certain aspects of consciousness and help +retrieve certain memories, but it cannot make you squawk like a chicken +without your permission. + +MIND-ALTERING DRUGS AND TRUTH SERUMS + +One of the goals of MKULTRA was the creation of a truth serum so that +spies and prisoners would reveal their secrets. Although MKULTRA was +canceled in 1973, U.S. Army and CIA interrogation manuals declassified +by the Pentagon in 1996 still recommended the use of truth serums +(although the U.S. Supreme Court ruled that confessions obtained in this +way were “unconstitutionally coerced” and hence inadmissible in court)." +"Anyone who watches Hollywood movies knows that sodium pentathol +is the truth serum of choice used by spies (as in the movies True Lies +with Arnold Schwarzenegger and Meet the Fockers with Robert De Niro). +Sodium pentathol is part of a larger class of barbiturates, sedatives, and +hypnotics that can evade the blood-brain barrier, which prevents most +harmful chemicals in the bloodstream from entering the brain." +"Not surprisingly, most mind-altering drugs, such as alcohol, affect us +powerfully because they can evade this barrier. Sodium pentathol +depresses activity in the prefrontal cortex, so that a person becomes +more relaxed, talkative, and uninhibited. However, this does not mean +that they tell the truth. On the contrary, people under the influence of +sodium pentathol, like those who have imbibed a few too many, are +fully capable of lying. The “secrets” that come spilling out of the mouth +of someone under this drug may be total fabrications, so even the CIA +eventually gave up on drugs like this. + +But this still leaves open the possibility that, one day, a wonder drug" +"But this still leaves open the possibility that, one day, a wonder drug + +might be found that could alter our basic consciousness. This drug would +work by changing the synapses between our nerve fibers by targeting +neurotransmitters that operate in this area, such as dopamine, serotonin, +or acetylcholine. If we think of the synapses as a series of tollbooths +along a superhighway, then certain drugs (such as stimulants like +cocaine) can open the tollbooth and let messages pass by unimpeded. +The sudden rush that drug addicts feel is caused when these tollbooths +are opened all at once, causing an avalanche of signals to flood by. But + + when all the synapses have fired in unison, they cannot fire again until +hours later. It’s as if the tolls have closed, and this causes the sudden +depression one feels after the rush. The body’s desire to reexperience the +sudden rush then causes addiction. + +HOW DRUGS ALTER THE MIND" +"HOW DRUGS ALTER THE MIND + +Although the biochemical basis for mind-altering drugs was not known +when the CIA first conducted its experiments on unsuspecting subjects, +since then the molecular basis of drug addiction has been studied in +detail. Studies in animals demonstrate how powerful drug addiction is: +rats, mice, and primates will, given the chance, take drugs like cocaine, +heroin, and amphetamines until they drop from exhaustion or die from +it." +"To see how widespread this problem has become, consider that by +2007, thirteen million Americans aged twelve or over (or 5 percent of +the entire teen and adult population of the United States) had tried or +become addicted to methamphetamines. Drug addiction not only +destroys entire lives, it also systematically destroys the brain. MRI scans +of the brains of meth addicts show an 11 percent reduction in the size of +the limbic system, which processes emotions, and an 8 percent loss of +tissue in the hippocampus, which is the gateway for memory. MRI scans +show that the damage in some ways is comparable to that found in +Alzheimer’s patients. But no matter how much meth destroys the brain, +addicts crave it because its high is up to twelve times the rush caused by +eating a delicious meal or even having sex. + +Basically, the “high” of drug addiction is due to the drug’s hijacking of +the brain’s own pleasure/reward system located in the limbic system." +"This pleasure/reward circuit is very primitive, dating back millions of +years in evolutionary history, but it is still extremely important for +human survival because it rewards beneficial behavior and punishes +harmful acts. Once this circuit is taken over by drugs, however, the +result can be widespread havoc. These drugs first penetrate the blood- +brain barrier and then cause the overproduction of neurotransmitters +like dopamine, which then floods the nucleus accumbens, a tiny pleasure +center located deep in the brain near the amygdala. The dopamine, in +turn, is produced by certain brain cells in the ventral tegmental area, +called VTA cells. + +All drugs basically work the same way: by crippling the VTA-nucleus +accumbens circuit, which controls the flow of dopamine and other +neurotransmitters to the pleasure center. Drugs differ only in the way in" +"which this process takes place. There are at least three main drugs that +stimulate the pleasure center of the brain: dopamine, serotonin, and +noradrenaline; all of them give feelings of pleasure, euphoria, and false +confidence, and also produce a burst of energy. + +Cocaine and other stimulants, for example, work in two ways. First, +they directly stimulate the VTA cells to produce more dopamine, hence +causing excess dopamine to flood into the nucleus accumbens. Second, +they prevent the VTA cells from going back to their “off” position, thus +keeping them continually producing dopamine. They also impede the +uptake of serotonin and noradrenaline. The simultaneous flooding of +neural circuits from all three of these neurotransmitters, then, creates +the tremendous high associated with cocaine. + +Heroin and other opiates, by contrast, work by neutralizing the cells in +the VTA that can reduce the production of dopamine, thus causing the +VTA to overproduce dopamine." +"Drugs like LSD operate by stimulating the production of serotonin, +inducing a feeling of well-being, purpose, and affection. But they also +activate areas of the temporal lobe involved in creating hallucinations. +(Only fifty micrograms of LSD can cause hallucinations. LSD binds so +tightly, in fact, that further increasing the dosage has no effect.) + +Over time, the CIA came to realize that mind-altering drugs were not +the magic bullet they were looking for. The hallucinations and +addictions that accompany these drugs made them too unstable and +unpredictable, and they could cause more trouble than they were worth + +in delicate political situations." +"(It should be pointed out that just in the last few years, MRI brain +scans of drug addicts have indicated a novel way to possibly cure or +treat some forms of addiction. By accident, it was noticed that stroke +victims who have damage to the insula [located deep in the brain, +between the prefrontal cortex and the temporal cortex] have a +significantly easier time quitting smoking than the average smoker. This +result has also been verified among drug abusers using cocaine, alcohol, +opiates, and nicotine. If this result holds up, it might mean that one may +be able to dampen the activity of the insula using electrodes or magnetic +stimulators and hence treat addiction. “This is the first time we’ve shown +anything like this, that damage to a specific brain area could remove the +problem of addiction entirely. It’s mind-boggling,” says Dr. Nora +Volkow, director of the National Institute on Drug Abuse. At present, no +one knows how this works, because the insula is involved in a" +"one knows how this works, because the insula is involved in a +bewildering variety of brain functions, including perception, motor +control, and self-awareness. But if this result bears out, it could change" +"the entire landscape of addiction studies.) + +PROBING THE BRAIN WITH OPTOGENETICS + +These mind-control experiments were done mainly in an era when the +brain was largely a mystery, with hit-or-miss methods that often failed. +However, because of the explosion in devices that can probe the brain, +new opportunities have arisen that will both help us understand the +brain as well as possibly teach us how to control it. + +Optogenetics, as we have seen, is one of the fastest-developing fields +in science today. The basic goal is to identify precisely which neural +pathway corresponds to which mode of behavior. Optogenetics starts +with a gene called opsin, which is quite unusual because it is sensitive to +light. (It is believed that the appearance of this gene hundreds of +millions of years ago was responsible for creating the first eye. In this +theory, a simple patch of skin sensitive to light due to opsin evolved into +the retina of the eye.)" +"When the opsin gene is inserted into a neuron and exposed to light, +the neuron will fire on command. By flipping a switch, one can instantly + +recognize the neural pathway for certain behaviors because the proteins +manufactured by opsin conduct electricity and will fire. + +The hard part, though, is to insert this gene into a single neuron. To +do this, one uses a technique borrowed from genetic engineering. The +opsin gene is inserted into a harmless virus (which has had its bad genes +removed), and, using precision tools, it is then possible to apply this +virus to a single neuron. The virus then infects the neuron by inserting +its genes into the genes of the neuron. Then, when a light beam is +flashed onto neural tissue, the neuron is turned on. In this way, one can +establish the precise pathway that certain messages take." +"Not only does optogenetics identify certain pathways by shining a +light beam on them, it also enables scientists to control behavior. +Already this method has been a proven success. It was long suspected +that a simple neural circuit must be responsible for fruit flies escaping +and flying away. Using this method, it was possible to finally identify the +precise pathway behind the quick getaway. By simply shining a beam +onto these fruit flies, they bolt on demand. + +Scientists are also now able to make worms stop wiggling by flashing +light, and in 2011 yet another breakthrough was made. Scientists at +Stanford were able to insert the opsin gene into a precise region of the + + amygdala of mice. These mice, which were specially bred to be timid, +cowered in their cage. But when a beam of light was flashed into their +brains, the mice suddenly lost their timidity and began to explore their +cage." +"The implications are enormous. While fruit flies may have simple +reflex mechanisms involving a handful of neurons, mice have complete +limbic systems with counterparts in the human brain. Although many +experiments that work with mice do not translate to human beings, this +still holds out the possibility that scientists may one day find the precise +neural pathways for certain mental illnesses, and then be able to treat +them without any side effects. As Dr. Edward Boyden of MIT says, “If +you want to turn off a brain circuit and the alternative is surgical +removal of a brain region, optical fiber implants might seem preferable.” + +One practical application is in treating Parkinson’s disease. As we have +seen, it can be treated by deep brain stimulation, but because the +positioning of electrodes in the brain lacks precision, there is always the +danger of strokes, bleeding, infections, etc. Deep brain stimulation can" +"also cause side effects such as dizziness and muscle contractions, because +the electrodes can accidentally stimulate the wrong neurons. +Optogenetics may improve deep brain stimulation by identifying the +precise neural pathways that are misfiring, at the level of individual +neurons. + +Victims of paralysis might also benefit from this new technology. As +we saw in Chapter 4, some paralyzed individuals have been hooked up +to a computer in order to control a mechanical arm, but because they +have no sense of touch, they often wind up dropping or crushing the +object they wish to grab. “By feeding information from sensors on the +prosthetic fingertips directly back to the brain using optogenetics, one +could in principle provide a high-fidelity sense of touch,” says Dr. +Krishna Shenoy of Stanford." +"Optogenetics will also help clarify which neural pathways are involved +with human behavior. In fact, plans have already been drawn up to +experiment with this technique on human brains, especially with regard +to mental illness. There will be hurdles, of course. First, the technique +requires opening up the skull, and if the neurons that one wishes to +study are located deep inside the brain, the procedure will be even more +invasive. Lastly, one has to insert tiny wires into the brain that can shine +a light on this modified neuron so that it triggers the desired behavior. + +Once these neural pathways have been deciphered, you can also +stimulate them, making animals perform strange behaviors (for example, +mice will run around in circles). Although scientists are just beginning to" +"trace the neural pathways governing simple animal behaviors, in the +future they should have an encyclopedia of such behaviors, including +those of humans. In the wrong hands, however, optogenetics could +potentially be used to control human behavior. + +In the main, the benefits of optogenetics greatly outweigh its +drawbacks. It can literally reveal the pathways of the brain in order to +treat mental illness and other diseases. This may then give scientists the +tools by which to repair the damage, perhaps curing diseases once +thought to be incurable. In the near future, then, the benefits are all +positive. But further in the future, once the pathways of human +behaviors are also understood, optogenetics could also be used to control +or at least modify human behavior as well. + +MIND CONTROL AND THE FUTURE" +"MIND CONTROL AND THE FUTURE + +In summary, the use of drugs and hypnotism by the CIA was a flop. +These techniques were too unstable and unpredictable to be of any use +to the military. They can be used to induce hallucinations and +dependency, but they have failed to cleanly erase memories, make +people more pliant, or force people to perform acts against their will. +Governments will keep trying, but the goal is elusive. So far, drugs are +simply too blunt an instrument to allow you to control someone’s +behavior. + +But this is also a cautionary tale. Carl Sagan mentions one nightmare +scenario that might actually work. He envisions a dictator taking +children and putting electrodes into their “pain” and “pleasure” centers. +These electrodes are then connected wirelessly to computers, so that the +dictator can control his subjects with the push of a button." +"Another nightmare might involve probes placed in the brain that +could override our wishes and seize control of our muscles, forcing us to +perform tasks we don’t want to do. The work of Dr. Delgado was crude, +but it showed that bursts of electricity applied to motor areas of the +brain can overrule our conscious thoughts, so that our muscles are no +longer under our control. He was able to identify only a few behaviors in +animals that could be controlled with electric probes. In the future, it +may be possible to find a wide variety of behaviors that can be +controlled electronically with a switch." +"If you are the person being controlled, it would be an unpleasant +experience. Although you may think you are master of your own body, +your muscles would actually fire without your permission, so you would +do things against your will. The electric impulse being fed into your +brain could be larger than the impulses you consciously send into your +muscles, so that it would appear as if someone had hijacked your body. + + Your own body would become a foreign object. + +In principle, some version of this nightmare might be possible in the +future. But there are several factors that may prevent this as well. First, +this is still an infant technology and it is not known how it will be +applied to human behavior, so there is still plenty of time to monitor its +development and perhaps create safeguards to see that it is not misused. +Second, a dictator might simply decide that propaganda and coercion," +"the usual methods of controlling a population, are cheaper and more +effective than putting electrodes into the brains of millions of children, +which would be costly and invasive. And third, in democratic societies, a +vigorous public debate would probably emerge concerning the promise +and limitations of this powerful technology. Laws would have to be +passed to prevent the abuse of these methods without impairing their +ability to reduce human suffering. Soon science will give us unparalleled +insight into the detailed neural pathways of the brain. A fine line has to +be drawn between technologies that can benefit society and technologies +that can control it. And the key to passing these laws is an educated, +informed public." +"But the real impact of this technology, I believe, will be to liberate the +mind, not enslave it. These technologies can give hope to those who are +trapped in mental illness. Although there is as yet no permanent cure for +mental illness, these new technologies have given us deep insight into +how such disorders form and how they progress. One day, through +genetics, drugs, and a combination of high-tech methods, we will find a +way to manage and eventually cure these ancient diseases. + +One of the recent attempts to exploit this new knowledge of the brain +is to understand historical personalities. Perhaps the insights from +modern science can help explain the mental states of those in the past. + +And one of the most mystifying figures being analyzed today is Joan +of Arc. + +Lovers and madmen have such seething brains.. +The lunatic, the lover, and the poet +Are of imagination all compact. + +-WILLIAM SHAKESPEARE, A MIDSUMMER NIGHT S DREAM + +9 ALTERED STATES OF CONSCIOUSNESS" +"-WILLIAM SHAKESPEARE, A MIDSUMMER NIGHT S DREAM + +9 ALTERED STATES OF CONSCIOUSNESS + + She was just an illiterate peasant girl who claimed to hear voices +directly from God. But Joan of Arc would rise from obscurity to lead a +demoralized army to victories that would change the course of nations, +making her one of the most fascinating, compelling, and tragic figures in +history." +"During the chaos of the Hundred Years’ War, when northern France +was decimated by English troops and the French monarchy was in +retreat, a young girl from Orleans claimed to have divine instructions to +lead the French army to victory. With nothing to lose, Charles VII +allowed her to command some of his troops. To everyone’s shock and +wonder, she scored a series of triumphs over the English. News rapidly +spread about this remarkable young girl. With each victory, her +reputation began to grow, until she became a folk heroine, rallying the +French around her. French troops, once on the verge of total collapse, +scored decisive victories that paved the way for the coronation of the +new king." +"However, she was betrayed and captured by the English. They realized +what a threat she posed to them, since she was a potent symbol for the +French and claimed guidance directly from God Himself, so they +subjected her to a show trial. After an elaborate interrogation, she was +found guilty of heresy and burned at the stake at the age of nineteen in +1431. + +In the centuries that followed, hundreds of attempts have been made +to understand this remarkable teenager. Was she a prophet, a saint, or a +madwoman? More recently, scientists have tried to use modern +psychiatry and neuroscience to explain the lives of historical figures such +as Joan of Arc. + +Few question her sincerity about claims of divine inspiration. But +many scientists have written that she might have suffered from +schizophrenia, since she heard voices. Others have disputed this fact," +"since the surviving records of her trial reveal a person of rational +thought and speech. The English laid several theological traps for her. +They asked, for example, if she was in God’s grace. If she answered yes, +then she would be a heretic, since no one can know for certain if they +are in God’s grace. If she said no, then she was confessing her guilt, and +that she was a fraud. Either way, she would lose. + +In a response that stunned the audience, she answered, “If I am not, +may God put me there; and if I am, may God so keep me.” The court +notary, in the records, wrote, “Those who were interrogating her were + + stupefied.” + +In fact, the transcripts of her interrogation are so remarkable that +George Bernard Shaw put literal translations of the court record in his +play Saint Joan." +"More recently, another theory has emerged about this exceptional +woman: perhaps she actually suffered from temporal lobe epilepsy. +People who have this condition sometimes experience seizures, but some +of them also experience a curious side effect that may shed some light on +the structure of human beliefs. These patients suffer from +“hyperreligiosity,” and can’t help thinking that there is a spirit or +presence behind everything. Random events are never random, but have +some deep religious significance. Some psychologists have speculated +that a number of history’s prophets suffered from these temporal lobe +epileptic lesions, since they were convinced they talked to God. The +neuroscientist Dr. David Eagleman says, “Some fraction of history’s +prophets, martyrs, and leaders appear to have had temporal lobe +epilepsy. Consider Joan of Arc, the sixteen-year-old girl who managed to +turn the tide of the Hundred Years’ War because she believed (and" +"turn the tide of the Hundred Years’ War because she believed (and +convinced the French soldiers) that she was hearing voices from Saint +Michael the archangel, Saint Catherine of Alexandria, Saint Margaret, +and Saint Gabriel.”" +"This curious effect was noticed as far back as 1892, when textbooks on +mental illness noted a link between “religious emotionalism” and +epilepsy. It was first clinically described in 1975 by neurologist Norman +Geschwind of Boston Veterans Administration Hospital. He noticed that +epileptics who had electrical misfirings in their left temporal lobes often +had religious experiences, and he speculated that the electrical storm in +the brain somehow was the cause of these religious obsessions. + +Dr. V. S. Ramachandran estimates that 30 to 40 percent of all the +temporal lobe epileptics whom he has seen suffer from hyperreligiosity. +He notes, “Sometimes it’s a personal God, sometimes it’s a more diffuse +feeling of being one with the cosmos. Everything seems suffused with +meaning. The patient will say, ‘Finally, I see what it is all really about, +Doctor. I really understand God. I understand my place in the universe— +the cosmic scheme.’ ”" +"He also notes that many of these individuals are extremely adamant +and convincing in their beliefs. He says, “I sometimes wonder whether +such patients who have temporal lobe epilepsy have access to another +dimension of reality, a wormhole of sorts into a parallel universe. But I +usually don’t say this to my colleagues, lest they doubt my sanity.” He +has experimented on patients with temporal lobe epilepsy, and +confirmed that these individuals had a strong emotional reaction to the + + word “God” but not to neutral words. This means that the link between +hyperreligiosity and temporal lobe epilepsy is real, not just anecdotal. + +Psychologist Michael Persinger asserts that a certain type of +transcranial electrical stimulation (called transcranial magnetic +simulation, or TMS) can deliberately induce the effect of these epileptic +lesions. If this is so, is it possible that magnetic fields can be used to alter +one’s religious beliefs?" +"In Dr. Persinger’s studies, the subject places a helmet on his head +(dubbed the “God helmet”), which contains a device that can send +magnetism into particular parts of the brain. Afterward, when the +subject is interviewed, he will often claim that he was in the presence of +some great spirit. David Biello, writing in Scientific American, says, +“During the three-minute bursts of stimulation, the affected subjects +translated this perception of the divine into their own cultural and +religious language—terming it God, Buddha, a benevolent presence, or +the wonder of the universe.” Since this effect is reproducible on demand, +it indicates that perhaps the brain is hardwired in some way to respond +to religious feelings." +"Some scientists have gone further and have speculated that there is a +“God gene” that predisposes the brain to be religious. Since most +societies have created a religion of some sort, it seems plausible that our +ability to respond to religious feelings might be genetically programmed +into our genome. (Meanwhile, some evolutionary theorists have tried to + +explain these facts by claiming that religion served to increase the +chances of survival for early humans. Religion helped bond bickering +individuals into a cohesive tribe with a common mythology, which +increased the chances that the tribe would stick together and survive.) + +Would an experiment like the one using the “God helmet” shake a +person’s religious beliefs? And can an MRI machine record the brain +activity of someone who experiences a religious awakening?" +"To test these ideas, Dr. Mario Beauregard of the University of +Montreal recruited a group of fifteen Carmelite nuns who agreed to put +their heads into an MRI machine. To qualify for the experiment, all of +them must “have had an experience of intense union with God.” + +Originally, Dr. Beauregard had hoped that the nuns would have a +mystical communion with God, which could then be recorded by an MRI +scan. However, being shoved into an MRI machine, where you are +surrounded by tons of magnetic coils of wire and high-tech equipment, is +not an ideal setting for a religious epiphany. The best they could do was +to evoke memories of previous religious experiences. “God cannot be + + summoned at will,” explained one of the nuns. + +The final result was mixed and inconclusive, but several regions of the +brain clearly lit up during this experiment: + +• The caudate nucleus, which is involved with learning and possibly +falling in love. (Perhaps the nuns were feeling the unconditional +love of God?)" +"• The insula, which monitors body sensations and social emotions. +(Perhaps the nuns were feeling close to the other nuns as they were +reaching out to God?) + +• The parietal lobe, which helps process spatial awareness. (Perhaps +the nuns felt they were in the physical presence of God?) + +Dr. Beauregard had to admit that so many areas of the brain were +activated, with so many different possible interpretations, that he could +not say for sure whether hyperreligiosity could be induced. However, it +was clear to him that the nuns’ religious feelings were reflected in their +brain scans. + +But did this experiment shake the nuns’ belief in God? No. In fact, the + +nuns concluded that God placed this “radio” in the brain so that we +could communicate with Him." +"nuns concluded that God placed this “radio” in the brain so that we +could communicate with Him. + +Their conclusion was that God created humans to have this ability, so +the brain has a divine antenna given to us by God so that we can feel His +presence. David Biello concludes, “Although atheists might argue that +finding spirituality in the brain implies that religion is nothing more +than divine delusion, the nuns were thrilled by their brain scans for +precisely the opposite reason: they seemed to provide confirmation of +God’s interactions with them.” Dr. Beauregard concluded, “If you are an +atheist and you live a certain kind of experience, you will relate it to the +magnificence of the universe. If you are a Christian, you will associate it +with God. Who knows. Perhaps they are the same thing.” + +Similarly, Dr. Richard Dawkins, a biologist at Oxford University and +an outspoken atheist, was once placed in the God helmet to see if his +religious beliefs would change. + +They did not." +"They did not. + +So in conclusion, although hyperreligiosity may be induced via +temporal lobe epilepsy and even magnetic fields, there is no convincing +evidence that magnetic fields can alter one’s religious views. + + MENTAL ILLNESS + +But there is another altered state of consciousness that brings great +suffering, both to the person experiencing it and to his or her family, and +this is mental illness. Can brain scans and high technology reveal the +origin of this affliction and perhaps lead to a cure? If so, one of the +largest sources of human suffering could be eliminated." +"For example, throughout history, the treatment of schizophrenia was +brutal and crude. People who suffer from this debilitating mental +disorder, which afflicts about 1 percent of the population, typically hear +imaginary voices and suffer from paranoid delusions and disorganized +thinking. Throughout history, they were considered to be “possessed” by +the devil and were banished, killed, or locked up. Gothic novels +sometimes refer to the strange, demented relative who lives in the +darkness of a hidden room or basement. The Bible even mentions an +incident when Jesus encountered two demoniacs. The demons begged + +Jesus to drive them into a herd of swine. He said, “Go then.” When the +demons entered the swine, the whole herd rushed down the bank and +drowned in the sea." +"Even today, you still see people with classic symptoms of +schizophrenia walking around having arguments with themselves. The +first indicators usually surface in the late teens (for men) or early +twenties (for women). Some schizophrenics have led normal lives and +even performed remarkable feats before the voices finally took over. The +most famous case is that of the 1994 Nobel Prize winner in economics, +John Nash, who was played by Russell Crowe in the movie A Beautiful +Mind. In his twenties, Nash did pioneering work in economics, game +theory, and pure mathematics at Princeton University. One of his +advisers wrote him a letter of recommendation with just one line: “This +man is a genius.” Remarkably, he was able to perform at such a high +intellectual level even while being hounded by delusions. He was finally +hospitalized when he had a breakdown at age thirty-one, and spent +many years in institutions or wandering around the world, fearing that +communist agents would kill him." +"At present, there is no precise, universally accepted way to diagnose +mental illness. There is hope, however, that one day scientists will use +brain scans and other high-tech devices to create accurate diagnostic +tools. Progress in treating mental illness, therefore, has been painfully +slow. After centuries of suffering, victims of schizophrenia had their first +sign of relief when antipsychotic drugs like thorazine were found + + accidentally in the 1950s that could miraculously control or even at +times eliminate the voices that haunted the mentally ill." +"It is believed that these drugs work by regulating the level of certain +neurotransmitters, such as dopamine. Specifically, the theory is that +these drugs block the functioning of D2 receptors of certain nerve cells, +thereby reducing the level of dopamine. (This theory, that hallucinations +were in part caused by excess dopamine levels in the limbic system and +prefrontal cortex, also explained why people taking amphetamines +experienced similar hallucinations.) + +Dopamine, because it is so essential for the synapses of the brain, has +been implicated in other disorders as well. One theory holds that +Parkinson’s disease is aggravated by a lack of dopamine in the synapses, +while Tourette’s syndrome can be triggered by an overabundance of it. + +(People with Tourette’s syndrome have tics and unusual facial +movements. A small minority of them uncontrollably speak obscene +words and make profane, derogatory remarks.)" +"More recently, scientists have zeroed in on another possible culprit: +abnormal glutamate levels in the brain. One reason for believing these +levels are involved is that PCP (angel dust) is known to create +hallucinations similar to those of schizophrenics by blocking a glutamate +receptor called NMDA. Clozapine, a relatively new drug for +schizophrenia that stimulates the production of glutamate, shows great +promise. + +However, these antipsychotic drugs are not a cure-all. In about 20 +percent of cases, such drugs stop all symptoms. About two-thirds find +some relief from their symptoms, but the rest are totally unaffected. +(According to one theory, antipsychotic drugs mimic a natural chemical +that is missing in schizophrenics’ brains, but it is not an exact copy. +Hence a patient has to try a variety of these antipsychotic drugs, almost +by trial and error. Moreover, they can have unpleasant side effects, so +schizophrenics often stop taking them and suffer a relapse.)" +"Recently, brain scans of schizophrenics taken while they were having +auditory hallucinations have helped explain this ancient disorder. For +example, when we silently talk to ourselves, certain parts of the brain +light up on an MRI scan, especially in the temporal lobe (such as in +Wernicke’s area). When a schizophrenic hears voices, the very same +areas of the brain light up. The brain works hard to construct a +consistent narrative, so schizophrenics try to make sense of these +unauthorized voices, believing they originate from strange sources, such +as Martians secretly beaming thoughts into their brains. Dr. Michael +Sweeney of Ohio State writes, “Neurons wired for the sensation of sound + + fire on their own, like gas-soaked rags igniting spontaneously in a hot, +dark garage. In the absence of sights and sounds in the surrounding +environment, the schizophrenic’s brain creates a powerful illusion of +reality.”" +"Notably, these voices seem to be coming from a third party, who often +gives the subject commands, which are mostly mundane but sometimes +violent. Meanwhile, the simulation centers in the prefrontal cortex seem +to be on automatic pilot, so in a way it’s as though the consciousness of +a schizophrenic is running the same sort of simulations we all do, except + +they’re done without his permission. The person is literally talking to +himself without his knowledge. + +HALLUCINATIONS + +The mind constantly generates hallucinations of its own, but for the +most part they are easily controlled. We see images that don’t exist or +hear spurious sounds, for example, so the anterior cingulate cortex is +vital to distinguish the real from the manufactured. This part of the +brain helps us distinguish between stimuli that are external and those +that are internally generated by the mind itself." +"However, in schizophrenics, it is believed that this system is damaged, +so that the person cannot distinguish real from imaginary voices. (The +anterior cingulate cortex is vital because it lies in a strategic place, +between the prefrontal cortex and the limbic system. The link between +these two areas is one of the most important in the brain, since one area +governs rational thinking, and the other emotions.) + +Hallucinations, to some extent, can be created on demand. +Hallucinations occur naturally if you place someone in a pitch-black +room, an isolation chamber, or a creepy environment with strange +noises. These are examples of “our eyes playing tricks on us.” Actually, +the brain is tricking itself, internally creating false images, trying to +make sense of the world and identify threats. This effect is called +“pareidolia.” Every time we look at clouds in the sky, we see images of +animals, people, or our favorite cartoon characters. We have no choice. +It is hardwired into our brains." +"In a sense, all images we see, both real and virtual, are hallucinations, +because the brain is constantly creating false images to “fill in the gaps.” +As we’ve seen, even real images are partly manufactured. But in the +mentally ill, regions of the brain such as the anterior cingulate cortex are +perhaps damaged, so the brain confuses reality and fantasy. + + THE OBSESSIVE MIND + +Another disorder in which drugs may be used to heal the mind is OCD +(obsessive-compulsive disorder). As we saw earlier, human + +consciousness involves mediating between a number of feedback +mechanisms. Sometimes, however, the feedback mechanisms are stuck in +the “on” position." +"One in forty Americans suffers from OCD. Cases can be mild, so that, +for example, people have to constantly go home to check that they +locked the door. The detective Adrian Monk on the TV show Monk has a +mild case of OCD. But OCD can also be so severe that people +compulsively scratch or wash their skin until it is left bleeding and raw. +Some people with OCD have been known to repeat obsessive behaviors +for hours, making it difficult to keep a job or have a family. + +Normally these types of compulsive behaviors, in moderation, are +actually good for us, since they help us keep clean, healthy, and safe. +That is why we evolved these behaviors in the first place. But someone +with OCD cannot stop this behavior, and it spirals out of control." +"Brain scans are now revealing how this takes place. They show that at +least three areas of the brain that normally help us keep ourselves +healthy get stuck in a feedback loop. First, there is the orbitofrontal +cortex, which we saw in Chapter 1 can act as a fact-checker, making sure +that we have properly locked the doors and washed our hands. It tells +us, “Hmm, something is wrong.” Second, the caudate nucleus, located in +the basal ganglia, governs learned activities that are automatic. It tells +the body to “do something.” And finally, we have the cingulate cortex, +which registers conscious emotions, including discomfort. It says, “I still +feel awful.”" +"Psychiatry professor Jeffrey Schwartz of UCLA has tried to put this all +together to explain how OCD gets out of hand. Imagine you have the +urge to wash your hands. The orbitofrontal cortex recognizes that +something is wrong, that your hands are dirty. The caudate nucleus kicks +in and causes you to automatically wash your hands. Then the cingulate +cortex registers satisfaction that your hands are clean. + +But in someone with OCD, this loop is altered. Even after he notices +that his hands are dirty and he washes them, he still has the +discomforting feeling that something is wrong, that they are still dirty. +So he is stuck in a feedback loop that won’t stop. + + In the 1960s, the drug clomipramine hydrochloride began to give OCD +patients some relief. This and other drugs developed since then raise +levels of the neurotransmitter serotonin in the body. They can reduce" +"symptoms of OCD by as much as 60 percent in clinical trials. Dr. +Schwartz says, “The brain’s gonna do what the brain’s gonna do, but you +don’t have to let it push you around.” These drugs are certainly not a +cure, but they have brought some relief to the sufferers of OCD. + +BIPOLAR DISORDER + +Another common form of mental illness is bipolar disorder, in which a +person suffers from extreme bouts of wild, delusional optimism, followed +by a crash and then periods of deep depression. Bipolar disorder also +seems to run in families and, curiously, strikes frequently in artists; +perhaps their great works of art were created during bursts of creativity +and optimism. A list of creative people who were afflicted by bipolar +disorder reads like a Who’s Who of Hollywood celebrities, musicians, +artists, and writers. Although the drug lithium seems to control many of +the symptoms of bipolar disorder, the causes are not entirely clear." +"One theory states that bipolar disorder may be caused by an +imbalance between the left and right hemispheres. Dr. Michael Sweeney +notes, “Brain scans have led researchers to generally assign negative +emotions such as sadness to the right hemisphere and positive emotions +such as joy to the left hemisphere. For at least a century, neuroscientists +have noticed a link between damage to the brain’s left hemisphere and +negative moods, including depression and uncontrollable crying. +Damage to the right, however, has been associated with a broad array of +positive emotions.”" +"So the left hemisphere, which is analytical and controls language, +tends to become manic if left to itself. The right hemisphere, on the +contrary, is holistic and tends to check this mania. Dr. V. S. +Ramachandran writes, “If left unchecked, the left hemisphere would +likely render a person delusional or manic.... So it seems reasonable to +postulate a ‘devil’s advocate’ in the right hemisphere that allows ‘you’ to +adopt a detached, objective (allocentric) view of yourself.” + +If human consciousness involves simulating the future, it has to +compute the outcomes of future events with certain probabilities. It +needs, therefore, a delicate balance between optimism and pessimism to +estimate the chances of success or failures for certain courses of action." +"But in some sense, depression is the price we pay for being able to +simulate the future. Our consciousness has the ability to conjure up all +sorts of horrific outcomes for the future, and is therefore aware of all the +bad things that could happen, even if they are not realistic." +"It is hard to verify many of these theories, since brain scans of people +who are clinically depressed indicate that many brain areas are affected. +It is difficult to pinpoint the source of the problem, but among the +clinically depressed, activity in the parietal and temporal lobes seems to +be suppressed, perhaps indicating that the person is withdrawn from the +outside world and living in their own internal world. In particular, the +ventromedial cortex seems to play an important role. This area +apparently creates the feeling that there is a sense of meaning and +wholeness to the world, so that everything seems to have a purpose. +Overactivity in this area can cause mania, in which people think they are +omnipotent. Underactivity in this area is associated with depression and +the feeling that life is pointless. So it is possible that a defect in this area +may be responsible for some mood swings. + +A THEORY OF CONSCIOUSNESS AND MENTAL ILLNESS" +"A THEORY OF CONSCIOUSNESS AND MENTAL ILLNESS + +So how does the space-time theory of consciousness apply to mental +illness? Can it give us a deeper insight into this disorder? As we +mentioned before, we define human consciousness as the process of +creating a model of our world in space and time (especially the future) +by evaluating many feedback loops in various parameters in order to +achieve a goal." +"We have proposed that the key function of human consciousness is to +simulate the future, but this is not a trivial task. The brain accomplishes +it by having these feedback loops check and balance one another. For +example, a skillful CEO at a board meeting tries to draw out the +disagreement among staff members and to sharpen competing points of +view in order to sift through the various arguments and then make a +final decision. In the same way, various regions of the brain make +diverging assessments of the future, which are given to the dorsolateral +prefrontal cortex, the CEO of the brain. These competing assessments are +then evaluated and weighed until a balanced final decision is made. + +We can now apply the space-time theory of consciousness to give us a +definition of most forms of mental illness: + +Mental illness is largely caused by the disruption of the +delicate checks and balances between competing feedback" +"loops that simulate the future (usually because one region of +the brain is overactive or underactive). + +Because the CEO of the mind (the dorsolateral prefrontal cortex) no +longer has a balanced assessment of the facts, due to this disruption in +feedback loops, it begins to make strange conclusions and act in bizarre +ways. The advantage of this theory is that it is testable. One has to +perform MRI scans of the brain of someone who is mentally ill as it +exhibits dysfunctional behavior, evaluating how its feedback loops are +performing, and compare it to the MRI scans of normal people. If this +theory is correct, the dysfunctional behavior (for example, hearing +voices or becoming obsessed) can be traced back to a malfunctioning of +the checks and balances between feedback loops. The theory can be +disproven if this dysfunctional behavior is totally independent of the +interplay between these regions of the brain." +"Given this new theory of mental illness, we can now apply it to +various forms of mental disorders, summarizing the previous discussion +in this new light. + +We saw earlier that the obsessive behavior of people suffering from +OCD might arise when the checks and balances between several +feedback loops are thrown out of balance: one registering something as +amiss, another carrying out corrective action, and another one signaling +that the matter has been taken care of. The failure of the checks and +balances within this loop can cause the brain to be locked into a vicious +cycle, so the mind never believes that the problem has been resolved." +"The voices heard by schizophrenics might arise when several feedback +loops are no longer balancing one another. One feedback loop generates +spurious voices in the temporal cortex (i.e., the brain is talking to itself). +Auditory and visual hallucinations are often checked by the anterior +cingulate cortex, so a normal person can differentiate between real and +fictitious voices. But if this region of the brain is not working properly, +the brain is flooded with disembodied voices that it believes are real. + +This can cause schizophrenic behavior. + +Similarly, the manic-depressive swings of someone with bipolar +disorder might be traced to an imbalance between the left and right +hemispheres. The necessary interplay between optimistic and pessimistic +assessments is thrown off balance, and the person oscillates wildly +between these two diverging moods." +"Paranoia may also be viewed in this light. It results from an imbalance +between the amygdala (which registers fear and exaggerates threats) and +the prefrontal cortex, which evaluates these threats and puts them into + + perspective. + +We should also stress that evolution has given us these feedback loops +for a reason: to protect us. They keep us clean, healthy, and socially +connected. The problem occurs when the dynamic between opposing +feedback loops is disrupted. + +This theory can be roughly summarized as follows: + +MENTAL ILLNESS + +Paranoia + +FEEDBACK LOOP #1 + +Perceiving a threat + +FEEDBACK LOOP #2 + +Discounting threats + +BRAIN REGION AFFECTED + +Amygdala/prefrontal lobe + +MENTAL ILLNESS + +Schizophrenia + +FEEDBACK LOOP #1 + +Creating voices + +FEEDBACK LOOP #2 + +Discounting voices + +BRAIN REGION AFFECTED + +Left temporal lobe/anterior cingulate cortex + +MENTAL ILLNESS + +Bipolar disorder + + FEEDBACK LOOP #1 + +Optimism + +FEEDBACK LOOP #2 + +Pessimism + +BRAIN REGION AFFECTED + +Left/right hemisphere" +"Optimism + +FEEDBACK LOOP #2 + +Pessimism + +BRAIN REGION AFFECTED + +Left/right hemisphere + +MENTAL ILLNESS + +OCD + +FEEDBACK LOOP #1 + +Anxiety + +FEEDBACK LOOP #2 + +Satisfaction + +BRAIN REGION AFFECTED + +Orbitofrontal cortex/caudate nucleus/cingulate cortex + +According to the space-time theory of consciousness, many forms of mental illness are typified by the +disruption of the +checks and balances of opposing feedback loops in the brain that simulate the future. Brain scans are +gradually +identifying which regions these are. A more complete understanding of mental illness will undoubtedly +reveal the +involvement of many more regions of the brain. This is only a preliminary sketch. + +DEEP BRAIN STIMULATION + +Although the space-time theory of consciousness may give us insight into +the origin of mental illness, it doesn’t tell us how to create new therapies +and remedies." +"How will science deal with mental illness in the future? This is hard to +predict, since we now realize that mental illness is not just one category, +but an entire range of illnesses that can afflict the mind in a bewildering +number of ways. Furthermore, the science behind mental illness is still in + + its infancy, with huge areas totally unexplored and unexplained. + +But a new method is being tried today to treat the unending agony of +people suffering from one of the most common yet stubbornly persistent +forms of mental disorder, depression, which afflicts twenty million +people in the United States. Ten percent of them, in turn, suffer from an +incurable form of depression that has resisted all medical advances. One +direct way of treating them, which holds much promise, is to place +probes deep inside certain regions of the brain." +"An important clue to this disorder was discovered by Dr. Helen +Mayberg and colleagues, then doing research at Washington University +Medical School. Using brain scans, they identified an area of the brain, +called Brodmann area 25 (also called the subcallosal cingulate region), +in the cerebral cortex that is consistently hyperactive in depressed +individuals for whom all other forms of treatment have been +unsuccessful." +"These scientists used deep brain stimulation (DBS) in this area, +inserting a small probe into the brain and applying an electrical shock, +much like a pacemaker. The success of DBS has been astonishing in the +treatment of various disorders. In the past decade, DBS has been used on +forty thousand patients for motor-related diseases, such as Parkinson’s +and epilepsy, which cause uncontrolled movements of the body. +Between 60 and 100 percent of patients report significant improvement +in controlling their shaking hands. More than 250 hospitals in the United +States alone now perform DBS treatments. + +But then Dr. Mayberg had the idea of applying DBS directly to +Brodmann area 25 to treat depression as well. Her team took twelve +patients who were clinically depressed and had shown no improvement +after exhaustive use of drugs, psychotherapy, and electroshock therapy." +"They found that eight of these chronically depressed individuals +immediately showed progress. Their success was so astonishing, in fact, +that other groups raced to duplicate these results and apply DBS to other +mental disorders. At present, DBS is being applied to thirty-five patients +at Emory University, and thirty at other institutions. + +Dr. Mayberg says, “Depression 1.0 was psychotherapy—people +arguing about whose fault it was. Depression 2.0 was the idea that it’s a +chemical imbalance. This is Depression 3.0. What has captured +everyone’s imagination is that, by dissecting a complex behavior + +disorder into its component systems, you have a new way of thinking +about it.”" +"disorder into its component systems, you have a new way of thinking +about it.” + + Although the success of DBS in treating depressed individuals is +remarkable, much more research needs to be done. First, it is not clear +why DBS works. It is thought that DBS destroys or impairs overactive +areas of the brain (as in Parkinson’s and Brodmann area 25) and is hence +effective only against ailments caused by such overactivity. Second, the +precision of this tool needs to be improved. Although this treatment has +been used to treat a variety of brain diseases, such as phantom limb pain +(when a person feels pain from a limb that has been amputated), +Tourette’s syndrome, and obsessive-compulsive disorder, the electrode +inserted into the brain is not precise, thus affecting perhaps several +million neurons rather than just the handful that are the source of +distress." +"Time will only improve the effectiveness of this therapy. Using MEM +technology, one can create microscopic electrodes able to stimulate only +a few neurons at a time. Nanotechnology may also make possible neural +nanoprobes that are one molecule thick, as in carbon nanotubes. And as +MRI sensitivity increases, our capability to guide these electrodes to +more specific areas of the brain should grow more precise. + +WAKING UP FROM A COMA + +Deep brain stimulation has branched into several different avenues of +research, including a beneficial side effect: increasing the number of +memory cells within the hippocampus. Yet another application is to +revive some individuals in a coma." +"Comas represent perhaps one of the most controversial forms of +consciousness, and often results in national headlines. The case of Terri +Schiavo, for example, riveted the public. Due to a heart attack, she +suffered a lack of oxygen, which caused massive brain injury. As a result, +Schiavo went into a coma in 1990. Her husband, with the approval of +doctors, wanted to allow her the dignity of dying peacefully. But her +family said this was cruelly pulling the plug on someone who still had +some responses to stimuli and might one day be miraculously revived. +They pointed out that there had been sensational cases in the past when + +coma patients suddenly regained consciousness after many years in a +vegetative state. + +Brain scans were used to settle the question. In 2003, most +neurologists, examining the CAT scans, concluded that the damage to +Schiavo’s brain was so extensive that she could never be revived, and +that she was in a permanent vegetative state (PVS). After she died in" +"2005, an autopsy confirmed these results—there was no chance of +revival. + +In some other cases involving coma patients, however, brain scans +show that the damage is not so severe, so there is a slim chance of +recovery. In the summer of 2007, a man in Cleveland woke up and +greeted his mother after undergoing deep brain stimulation. The man +had suffered extensive brain damage eight years earlier and fell into a +deep coma known as a minimally conscious state." +"Dr. Ali Rezai led the team of surgeons who performed the operation. +They inserted a pair of wires into the patient’s brain until they reached +the thalamus, which, as we have seen, is the gateway where sensory +information is first processed. By sending a low-voltage current through +these wires, the doctors were able to stimulate the thalamus, which in +turn woke the man up from his deep coma. (Usually, sending electricity +into the brain causes that part of the brain to shut down, but under +certain circumstances it can act to jolt neurons into action.)" +"Improvements in DBS technology should increase the number of +success stories in different fields. Today a DBS electrode is about 1.5 +millimeters in diameter, but it touches up to a million neurons when +inserted into the brain, which can cause bleeding and damage to blood +vessels. One to three percent of DBS patients in fact have bleeding that +can progress to a stroke. The electric charge carried by DBS probes is +also still very crude, pulsing at a constant rate. Eventually, surgeons will +be able to adjust the electrical charge carried by the electrodes so that +each probe is made for a specific person and a specific ailment. The next +generation of DBS probes is bound to be safer and more precise. + +THE GENETICS OF MENTAL ILLNESS + +Another attempt to understand and eventually treat mental illness" +"Another attempt to understand and eventually treat mental illness + +involves tracing its genetic roots. Many attempts have been made in this +area, with disappointing, mixed results. There is considerable evidence +that schizophrenia and bipolar disorder run in families, but attempts to +find the genes common to all these individuals have not been conclusive. +Occasionally scientists have followed the family trees of certain +individuals afflicted by mental illness and found a gene that is prevalent. +But attempts to generalize this result to other families have often failed. +At best, scientists have concluded that environmental factors as well as a +combination of several genes are necessary to trigger mental illness. +However, it has generally been accepted that each disorder has its own +genetic basis." +"In 2012, however, one of the most comprehensive studies ever done +showed that there could in fact be a common genetic factor to mental +illness after all. Scientists from the Harvard Medical School and +Massachusetts General Hospital analyzed sixty thousand people +worldwide and found that there was a genetic link between five major +mental illnesses: schizophrenia, bipolar disorder, autism, major +depression, and attention deficit hyperactivity disorder (ADHD). +Together they represent a significant fraction of all mentally ill patients." +"After an exhaustive analysis of the subjects’ DNA, scientists found that +four genes increased the risk of mental illness. Two of them involved the +regulation of calcium channels in neurons. (Calcium is an essential +chemical involved in the processing of neural signals.) Dr. Jordan +Smoller of the Harvard Medical School says, “The calcium channels +findings suggest that perhaps—and that is a big if—treatments to affect +calcium channeling functioning might have effects across a range of +disorders.” Already, calcium channel blockers are being used to treat +people with bipolar disorder. In the future, these blockers may be used +to treat other mental illnesses as well. + +This new result could help explain the curious fact that when mental +illness runs in a family, members may manifest different forms of +disorders. For example, if one twin has schizophrenia, then the other +twin might have a totally different disorder, such as bipolar disorder." +"The point here is that although each mental illness has its own triggers +and genes, there could be a common thread running through them as +well. Isolating the common factors among these diseases could give us a +clue to which drugs might be most effective against them. + +“What we have identified here is probably just the tip of the iceberg,” +says Dr. Smoller. “As these studies grow, we expect to find additional +genes that might overlap.” If more genes are found among these five +disorders, it could open up an entirely new approach to mental illness. + +If more common genes are found, it could mean that gene therapy +might be able to repair the damage caused by defective genes. Or it +might give rise to new drugs that could treat the illness at the neural +level. + +FUTURE AVENUES + +So at present, there is no cure for patients with mental illness. +Historically, doctors were helpless in treating them. But modern" +"medicine has given us a variety of new possibilities and therapies to +tackle this ancient problem. Just a few of them include: + +1. Finding new neurotransmitters and new drugs that regulate the +signaling of neurons. + +2. Locating the genes linked to various mental illnesses, and perhaps +using gene therapy. + +3. Using deep brain stimulation to dampen or increase neural activity +in certain areas. + +4. Using EEG, MRI, MEG, and TES to understand precisely how the +brain malfunctions. + +5. And in the chapter on reverse engineering the brain, we will +explore yet another promising avenue, imaging the entire brain and +all its neural pathways. This may finally unravel the mystery of +mental illnesses. + +But to make sense of the wide variety of mental illnesses, some +scientists believe that mental illnesses can be grouped into at least two +major groups, each one requiring a different approach: + +1. Mental disorders involving injury to the brain" +"1. Mental disorders involving injury to the brain + +2. Mental disorders triggered by incorrect wiring within the brain + +The first type includes Parkinson’s, epilepsy, Alzheimer’s, and a wide +variety of disorders caused by strokes and tumors, in which brain tissue +is actually injured or malfunctioning. In the case of Parkinson’s and +epilepsy, there are neurons in a precise area of the brain that are +overactive. In Alzheimer’s, a buildup of amyloid plaque destroys brain +tissue, including the hippocampus. In strokes and tumors, certain parts +of the brain are silenced, causing numerous behavioral problems. Each +of these disorders has to be treated differently, since each injury is +different. Parkinson’s and epilepsy may require probes to silence the +overactive areas, while damage from Alzheimer’s, strokes, and tumors is +often incurable." +"In the future, there will be advances in methods to deal with these +injured parts of the brain besides deep brain stimulation and magnetic +fields. One day stem cells may replace brain tissue that has been +damaged. Or perhaps artificial replacements can be found to compensate +for these injured areas using computers. In this case, the injured tissue is +removed or replaced, either organically or electronically. + + The second category involves disorders caused by a miswiring of the +brain. Disorders like schizophrenia, OCD, depression, and bipolar +disorder might fall into this category. Each region of the brain may be +relatively healthy and intact, but one or more of them may be miswired, +causing messages to be processed incorrectly. This category is difficult to +treat, since the wiring of the brain is not well understood. So far, the +main way to deal with these disorders is through drugs that influence +neurotransmitters, but there is still a lot of hit or miss involved here." +"But there is another altered state of consciousness that has given us +new insights into the working mind. It has also provided new +perspectives on how the brain works and what might happen if there is a +disorder. This is the field of AI, artificial intelligence. Although it is still +in its infancy, it has opened profound insights into the thinking process +and has even deepened our understanding of human consciousness. So +the questions are: Can silicon consciousness be achieved? If so, how +might it differ from human consciousness? And will it try one day to +control us? + +No, I’m not interested in developing a powerful brain. All I’m +after is just a mediocre brain, something like the President of +the American Telephone and Telegraph Company. + +—ALAN TURING + +10 THE ARTIFICIAL MIND AND SILICON +CONSCIOUSNESS + +In February 2011, history was made." +"10 THE ARTIFICIAL MIND AND SILICON +CONSCIOUSNESS + +In February 2011, history was made. + +An IBM computer called Watson did what many critics thought was +impossible: it beat two contestants on a TV game show called Jeopardy! +Millions of viewers were glued to the screen as Watson methodically +annihilated its opponents on national TV, answering questions that +stumped the rival contestants, and thereby claiming the $1 million prize +money. + +IBM pulled out all the stops in assembling a machine with a truly +monumental amount of computational firepower. Watson can process +data at the astonishing rate of five hundred gigabytes per second (or the +equivalent of a million books per second) with sixteen trillion bytes of +RAM memory. It also had access to two hundred million pages of +material in its memory, including the entire storehouse of knowledge + + within Wikipedia. Watson could then analyze this mountain of +information on live TV." +"within Wikipedia. Watson could then analyze this mountain of +information on live TV. + +Watson is just the latest generation of “expert systems,” software +programs that use formal logic to access vast amounts of specialized +information. (When you talk on the phone to a machine that gives you a +menu of choices, this is a primitive expert system.) Expert systems will +continue to evolve, making our lives more convenient and efficient. + +For example, engineers are currently working to create a “robo-doc,” +which will appear on your wristwatch or wall screen and give you basic +medical advice with 99 percent accuracy almost for free. You’d talk to it +about your symptoms, and it would access the databanks of the world’s +leading medical centers for the latest scientific information. This will +reduce unnecessary visits to the doctor, eliminate costly false alarms, +and make it effortless to have regular conversations with a doctor." +"Eventually we might have robot lawyers that can answer all common +legal questions, or a robo-secretary that can plan vacations, trips, and + +dinners. (Of course, for specialized services requiring professional +advice, you would still need to see a real doctor, lawyer, etc., but for +common, everyday advice, these programs would suffice.) + +In addition, scientists have created “chat-bots” that can mimic +ordinary conversations. The average person may know tens of thousands +of words. Reading the newspaper may require about two thousand words +or more, but a casual conversation usually involves only a few hundred. +Robots can be programmed to converse with this limited vocabulary (as +long as the conversation is limited to certain well-defined subjects). + +MEDIA HYPE—THE ROBOTS ARE COMING" +"MEDIA HYPE—THE ROBOTS ARE COMING + +Soon after Watson won that contest, some pundits were wringing their +hands, mourning the day when the machines will take over. Ken +Jennings, one of the contestants defeated by Watson, remarked to the +press, “I for one welcome our new computer overlords.” The pundits +asked, If Watson could defeat seasoned game show contestants in a +head-to-machine contest, then what chance do the rest of us mortals +have to stand up to the machines? Half jokingly, Jennings said, “Brad +[the other contestant] and I were the first knowledge-industry workers +put out of work by the new generation of ‘thinking’ machines.” + +The commentators, however, forgot to mention that you could not go +up to Watson and congratulate it for winning. You could not slap it on" +"its back, or share a champagne toast with it. It wouldn’t know what any +of that meant, and in fact Watson was totally unaware that it had won at +all. All the hype aside, the truth is that Watson is a highly sophisticated +adding machine, able to add (or search data files) billions of times faster +than the human brain, but it is totally lacking in self-awareness or +common sense. + +On one hand, progress in artificial intelligence has been astounding, +especially in the area of raw computational power. Someone from the +year 1900, viewing the calculations performed by computers today, +would consider these machines to be miracles. But in another sense, +progress has been painstakingly slow in building machines that can think +for themselves (i.e., true automatons, without a puppet master, a +controller with a joystick, or someone with a remote-control panel). + +Robots are totally unaware that they are robots." +"Robots are totally unaware that they are robots. + +Given the fact that computer power has been doubling every two years +for the past fifty years under Moore’s law, some say it is only a matter of +time before machines eventually acquire self-awareness that rivals +human intelligence. No one knows when this will happen, but humanity +should be prepared for the moment when machine consciousness leaves +the laboratory and enters the real world. How we deal with robot +consciousness could decide the future of the human race. + +BOOM AND BUST CYCLES IN AI" +"BOOM AND BUST CYCLES IN AI + +It is difficult to foretell the fate of AI, since it has gone through three +cycles of boom and bust. Back in the 1950s, it seemed as if mechanical +maids and butlers were just around the corner. Machines were being +built that could play checkers and solve algebra problems. Robot arms +were developed that could recognize and pick up blocks. At Stanford +University, a robot was built called Shakey—basically a computer sitting +on top of wheels with a camera—which could wander around a room by +itself, avoiding obstacles." +"Breathless articles were soon published in science magazines heralding +the coming of the robot companion. Some predictions were too +conservative. In 1949, Popular Mechanics stated that “in the future, +computers will weigh no more than 1.5 tons.” But others were wildly +optimistic in proclaiming that the day of the robots was near. Shakey +would one day become a mechanical maid or butler that would vacuum +our carpets and open our doors. Movies like 2001: A Space Odyssey +convinced us that robots would soon be piloting our rocket ships to +Jupiter and chatting with our astronauts. In 1965, Dr. Herbert Simon, + + one of the founders of AI, said flatly, “Machines will be capable, within +20 years, of doing any work a man can do.” Two years later, another +founding father of AI, Dr. Marvin Minsky, said that “within a +generation ... the problem of creating ‘artificial intelligence’ will +substantially be solved.”" +"But all this unbounded optimism collapsed in the 1970s. Checker¬ +playing machines could only play checkers, nothing more. Mechanical +arms could pick up blocks, but nothing else. They were like one-trick + +ponies. The most advanced robots took hours just to walk across a room. +Shakey, placed in an unfamiliar environment, would easily get lost. And +scientists were nowhere near understanding consciousness. In 1974, AI +suffered a huge blow when both the U.S. and British governments +substantially curtailed funding in the field." +"But as computer power steadily increased in the 1980s, a new gold +rush occurred in AI, fueled mainly by Pentagon planners hoping to put +robot soldiers on the battlefield. Funding for AI hit a billion dollars by +1985, with hundreds of millions of dollars spent on projects like the +Smart Truck, which was supposed to be an intelligent, autonomous truck +that could enter enemy lines, do reconnaissance by itself, perform +missions (such as rescuing prisoners), and then return to friendly +territory. Unfortunately, the only thing that the Smart Truck did was get +lost. The visible failures of these costly projects created yet another AI +winter in the 1990s. + +Paul Abrahams, commenting about the years he spent at MIT as a +graduate student, has said, “It’s as though a group of people had +proposed to build a tower to the moon. Each year, they point with pride +at how much higher the tower is than it was the previous year. The only +trouble is that the moon isn’t getting much closer.”" +"But now, with the relentless march of computer power, a new AI +renaissance has begun, and slow but substantial progress has been made. +In 1997, IBM’s Deep Blue computer beat world chess champion Garry +Kasparov. In 2005, a robot car from Stanford won the DARPA Grand +Challenge for a driverless car. Milestones continue to be reached. + +This question remains: Is the third try the charm? + +Scientists now realize that they vastly underestimated the problem, +because most human thought is actually subconscious. The conscious +part of our thoughts, in fact, represents only the tiniest portion of our +computations. + +Dr. Steve Pinker says, “I would pay a lot for a robot that would put + + away the dishes or run simple errands, but I can’t, because all of the +little problems that you’d need to solve to build a robot do to that, like +recognizing objects, reasoning about the world, and controlling hands +and feet, are unsolved engineering problems.”" +"Although Hollywood movies tell us that terrifying Terminator robots +may be just around the corner, the task of creating an artificial mind has + +been much more difficult than previously thought. I once asked Dr. +Minsky when machines would equal and perhaps even surpass human +intelligence. He said that he was confident this would happen but that +he doesn’t make predictions about dates anymore. Given the roller¬ +coaster history of AI, perhaps this is the wisest approach, to map out the +future of AI without setting a specific timetable. + +PATTERN RECOGNITION AND COMMON SENSE + +There are at least two basic problems confronting AI: pattern recognition +and common sense." +"There are at least two basic problems confronting AI: pattern recognition +and common sense. + +Our best robots can barely recognize simple objects like a cup or a +ball. The robot’s eye may see details better than a natural eye, but the +robot brain cannot recognize what it is seeing. If you place a robot on a +strange, busy street, it quickly becomes disoriented and gets lost. Pattern +recognition (e.g., identifying objects) has progressed much more slowly +than previously estimated because of this problem." +"When a robot walks into a room, it has to perform trillions of +calculations, breaking down the objects it sees into pixels, lines, circles, +squares, and triangles, and then trying to make a match with the +thousands of images stored in its memory. For instance, robots see a +chair as a hodgepodge of lines and dots, but they cannot easily identify +the essence of “chairness.” Even if a robot is able to successfully match +an object to an image in its database, a slight rotation (like a chair that’s +been knocked over on the floor) or change in perspective (viewing the +chair from a different angle) will mystify the robot. Our brains, however, +automatically take different perspectives and variations into account. +Our brains are subconsciously performing trillions of calculations, but +the process seems effortless to us." +"Robots also have a problem with common sense. They do not +understand simple facts about the physical and biological world. There +isn’t an equation that can confirm something as self-evident (to us +humans) as “muggy weather is uncomfortable” or “mothers are older +than their daughters.” There has been some progress made in translating + + this sort of information into mathematical logic, but to catalog the +common sense of a four-year-old child would require hundreds of + +millions of lines of computer code. As Voltaire once said, “Common +sense is not so common.” + +For example, one of our most advanced robots is called ASIMO, built +in Japan (where 30 percent of all industrial robots are made) by the +Honda Corporation. This marvelous robot, about the size of a young boy, +can walk, run, climb stairs, speak different languages, and dance (much +better than I do, in fact). I have interacted with ASIMO on TV several +times, and was very impressed by its abilities." +"However, I met privately with the creators of ASIMO and asked them +this key question: How smart is ASIMO, if we compare it to an animal? +They admitted to me that it has the intelligence of a bug. All the walking +and talking is mostly for the press. The problem is that ASIMO is, by and +large, a big tape recorder. It has only a modest list of truly autonomous +functions, so almost every speech or motion has to be carefully scripted +ahead of time. For example, it took about three hours to film a short +sequence of me interacting with ASIMO, because the hand gesture and +other movement had to be programmed by a team of handlers." +"If we consider this in relation to our definition of human +consciousness, it seems that our current robots are stuck at a very +primitive level, simply trying to make sense of the physical and social +world by learning basic facts. As a consequence, robots are not even at +the stage where they can plot realistic simulations of the future. Asking a +robot to craft a plan to rob a bank, for instance, assumes that the robot +knows all the fundamentals about banks, such as where the money is +stored, what sort of security system is in place, and how the police and +bystanders will react to the situation. Some of this can be programmed, +but there are hundreds of nuances that the human mind naturally +understands but robots do not." +"Where robots excel is in simulating the future in just one precise field, +such as playing chess, modeling the weather, tracing the collision of +galaxies, etc. Since the laws of chess and gravity have been well known +for centuries, it is only a matter of raw computer power to simulate the +future of a chess game or a solar system. + +Attempts to move beyond this level using brute force have also +floundered. One ambitious program, called CYC, was designed to solve +the commonsense problem. CYC would include millions of lines of +computer code containing all the information of common sense and + + knowledge necessary to understand its physical and social environment. +Although CYC can process hundreds of thousands of facts and millions of +statements, it still cannot reproduce the level of thought of a four-year- +old human. Unfortunately, after some optimistic press releases, the effort +has stagnated. Many of its programmers left, deadlines have come and +gone, and yet the project still continues." +"IS THE BRAIN A COMPUTER? + +Where did we go wrong? For the past fifty years, scientists working in AI +have tried to model the brain by following the analogy with digital +computers. But perhaps this was too simplistic. As Joseph Campbell once +said, “Computers are like Old Testament gods; lots of rules and no +mercy.” If you remove a single transistor from a Pentium chip, the +computer will crash immediately. But the human brain can perform +quite well even if half of it is missing." +"This is because the brain is not a digital computer at all, but a highly +sophisticated neural network of some sort. Unlike a digital computer, +which has a fixed architecture (input, output, and processor), neural +networks are collections of neurons that constantly rewire and reinforce +themselves after learning a new task. The brain has no programming, no +operating system, no Windows, no central processor. Instead, its neural +networks are massively parallel, with one hundred billion neurons firing +at the same time in order to accomplish a single goal: to learn." +"In light of this, AI researchers are beginning to reexamine the “top- +down approach” they have followed for the last fifty years (e.g., putting +all the rules of common sense on a CD). Now AI researchers are giving +the “bottom-up approach” a second look. This approach tries to follow +Mother Nature, which has created intelligent beings (us) via evolution, +starting with simple animals like worms and fish and then creating more +complex ones. Neural networks must learn the hard way, by bumping +into things and making mistakes. + +Dr. Rodney Brooks, former director of the famed MIT Artificial +Intelligence Laboratory, and cofounder of iRobot, which makes those +mechanical vacuum cleaners found in many living rooms, introduced an +entirely new approach to AI. Instead of designing big, clumsy robots," +"why not build small, compact, insectlike robots that have to learn how +to walk, just as in nature?When I interviewed him, he told me that he +used to marvel at the mosquito, which had a nearly microscopic brain +with very few neurons, yet was able to maneuver in space better than + + any robot airplane. He built a series of remarkably simple robots, +affectionately called “insectoids” or “bugbots,” which scurried around +the floors of MIT and could run circles around the more traditional +robots. The goal was to create robots that follow the trial-and-error +method of Mother Nature. In other words, these robots learn by bumping +into things. + +(At first, it may seem that this requires a lot of programming. The +irony, however, is that neural networks require no programming at all. +The only thing that the neural network does is rewire itself, by changing +the strength of certain pathways each time it makes a right decision. So +programming is nothing; changing the network is everything.)" +"Science-fiction writers once envisioned that robots on Mars would be +sophisticated humanoids, walking and moving just like us, with complex +programming that gave them human intelligence. The opposite has +happened. Today the grandchildren of this approach—like the Mars +Curiosity rover—are now roaming over the surface of Mars. They are not +programmed to walk like a human. Instead, they have the intelligence of +a bug, but they do quite fine in this terrain. These Mars rovers have +relatively little programming; instead, they learn as they bump into +obstacles. + +ARE ROBOTS CONSCIOUS?" +"ARE ROBOTS CONSCIOUS? + +Perhaps the clearest way to see why true robot automatons do not yet +exist is to rank their level of consciousness. As we have seen in Chapter +2, we can rank consciousness in four levels. Level 0 consciousness +describes thermostats and plants; that is, it involves a few feedback loops +in a handful of simple parameters such as temperature or sunlight. Level +I consciousness describes insects and reptiles, which are mobile and have +a central nervous system; it involves creating a model of your world in +relationship to a new parameter, space. Then we have Level II +consciousness, which creates a model of the world in relationship to + +others of its kind, requiring emotions. Finally we have Level III +consciousness, which describes humans, who incorporate time and self- +awareness to simulate how things will evolve in the future and +determine our own place in these models." +"We can use this theory to rank the robots of today. The first +generation of robots were at Level 0, since they were static, without +wheels or treads. Today’s robots are at Level I, since they are mobile, but +they are at a very low echelon because they have tremendous difficulty +navigating in the real world. Their consciousness can be compared to +that of a worm or slow insect. To fully produce Level I consciousness, + + scientists will have to create robots that can realistically duplicate the +consciousness of insects and reptiles. Even insects have abilities that +current robots do not have, such as rapidly finding hiding places, +locating mates in the forest, recognizing and evading predators, or +finding food and shelter." +"As we mentioned earlier, we can numerically rank consciousness by +the number of feedback loops at each level. Robots that can see, for +example, may have several feedback loops because they have visual +sensors that can detect shadows, edges, curves, geometric shapes, etc., in +three-dimensional space. Similarly, robots that can hear require sensors +that can detect frequency, intensity, stress, pauses, etc. The total number +of these feedback loops may total ten or so (while an insect, because it +can forage in the wild, find mates, locate shelter, etc., may have fifty or +more feedback loops). A typical robot, therefore, may have Level 1:10 +consciousness." +"Robots will have to be able to create a model of the world in relation +to others if they are to enter Level II consciousness. As we mentioned +before, Level II consciousness, to a first approximation, is computed by +multiplying the number of members of its group times the number of +emotions and gestures that are used to communicate between them. +Robots would thus have a consciousness of Level 11:0. But hopefully, the +emotional robots being built in labs today may soon raise that number. + +Current robots view humans as simply a collection of pixels moving on +their TV sensors, but some AI researchers are beginning to create robots +that can recognize emotions in our facial expressions and tone of voice. +This is a first step toward robots’ realizing that humans are more than +just random pixels, and that they have emotional states." +"In the next few decades, robots will gradually rise in Level II +consciousness, becoming as intelligent as a mouse, rat, rabbit, and then a +cat. Perhaps late in this century, they will be as intelligent as a monkey, +and will begin to create goals of their own. + +Once robots have a working knowledge of common sense and the +Theory of Mind, they will be able to run complex simulations into the +future featuring themselves as the principal actors and thus enter Level +III consciousness. They will leave the world of the present and enter the +world of the future. This is many decades beyond the capability of any +robot today. Running simulations of the future means that you have a +firm grasp of the laws of nature, causality, and common sense, so that +you can anticipate future events. It also means that you understand +human intentions and motivations, so you can predict their future +behavior as well." +"The numerical value of Level III consciousness, as we mentioned, is +calculated by the total number of causal links one can make in +simulating the future in a variety of real-life situations, divided by the +average value of a control group. Computers today are able to make +limited simulations in a few parameters (e.g., the collision of two +galaxies, the flow of air around an airplane, the shaking of buildings in +an earthquake), but they are totally unprepared to simulate the future in +complex, real-life situations, so their level of consciousness would be +something like Level III: 5. + +As we can see, it may take many decades of hard work before we have +a robot that can function normally in human society. + +SPEED BUMPS ON THE WAY" +"SPEED BUMPS ON THE WAY + +So when might robots finally match and exceed humans in intelligence? +No one knows, but there have been many predictions. Most of them rely +on Moore’s law extending decades into the future. However, Moore’s law +is not a law at all, and in fact it ultimately violates a fundamental +physical law: the quantum theory. + +As such, Moore’s law cannot last forever. In fact, we can already see it +slowing down now. It might flatten out by the end of this or the next +decade, and the consequences could be dire, especially for Silicon Valley." +"The problem is simple. Right now, you can place hundreds of millions +of silicon transistors on a chip the size of your fingernail, but there is a +limit to how much you can cram onto these chips. Today the smallest +layer of silicon in your Pentium chip is about twenty atoms in width, +and by 2020 that layer might be five atoms across. But then Heisenberg’s +uncertainty principle kicks in, and you wouldn’t be able to determine +precisely where the electron is and it could “leak out” of the wire. (See +the Appendix, where we discuss the quantum theory and the uncertainty +principle in more detail.) The chip would short-circuit. In addition, it +would generate enough heat to fry an egg on it. So leakage and heat will +eventually doom Moore’s law, and a replacement will soon be necessary." +"If packing transistors on flat chips is maxing out in computing power, +Intel is making a multibillion-dollar bet that chips will rise into the third +dimension. Time will tell if this gamble pays off (one major problem +with 3-D chips is that the heat generated rises rapidly with the height of +the chip). + +Microsoft is looking into other options, such as expanding into 2-D +with parallel processing. One possibility is to spread chips horizontally + + in a row. Then you break up a software problem into pieces, sort out +each piece on a small chip, and reassemble it at the end. However, it +may be a difficult process, and software grows at a much slower pace +than the supercharged exponential rate we are accustomed to with +Moore’s law." +"These stopgap measures may add years to Moore’s law. But eventually, +all this must pass, too: the quantum theory inevitably takes over. This +means that physicists are experimenting with a wide variety of +alternatives after the Age of Silicon draws to a close, such as quantum +computers, molecular computers, nanocomputers, DNA computers, +optical computers, etc. None of these technologies, however, is ready for +prime time. + +THE UNCANNY VALLEY + +But assume for the moment that one day we will coexist with incredibly +sophisticated robots, perhaps using chips with molecular transistors +instead of silicon. How closely do we want our robots to look like us?" +"Japan is the world’s leader in creating robots that resemble cuddly pets +and children, but their designers are careful not to make their robots +appear too human, which can be unnerving. This phenomenon was first +studied by Dr. Masahiro Mori in Japan in 1970, and is called the +“uncanny valley.” It posits that robots look creepy if they look too much +like humans. (The effect was actually first mentioned by Darwin in 1839 +in The Voyage of the Beagle and again by Freud in 1919 in an essay titled +“The Uncanny.”) Since then, it has been studied very carefully not just +by AI researchers but also by animators, advertisers, and anyone +promoting a product involving humanlike figures. For instance, in a +review of the movie The Polar Express, a CNN writer noted, “Those +human characters in the film come across as downright ... well, creepy. +So The Polar Express is at best disconcerting, and at worst, a wee bit +horrifying.”" +"According to Dr. Mori, the more a robot looks like a human, the more +we feel empathy toward it, but only up to a point. There is a dip in +empathy as the robot approaches actual human appearance—hence the +uncanny valley. If the robot looks very similar to us save for a few +features that are “uncanny,” it creates a feeling of revulsion and fear. If +the robot appears 100 percent human, indistinguishable from you and +me, then we’ll register positive emotions again. + +This has practical implications. For example, should robots smile? At +first, it seems obvious that robots should smile to greet people and make" +"them feel comfortable. Smiling is a universal gesture that signals warmth +and welcome. But if the robot smile is too realistic, it makes people’s +skin crawl. (For example, Halloween masks often feature fiendish- +looking ghouls that are grinning.) So robots should smile only if they are +childlike (i.e., with big eyes and a round face) or are perfectly human, +and nothing in between. (When we force a smile, we activate facial +muscles with our prefrontal cortex. But when we smile because we are in +a good mood, our nerves are controlled by our limbic system, which +activates a slightly different set of muscles. Our brains can tell the subtle +difference between the two, which was beneficial for our evolution.) + +This effect can also be studied using brain scans. Let’s say that a +subject is placed into an MRI machine and is shown a picture of a robot +that looks perfectly human, except that its bodily motions are slightly +jerky and mechanical. The brain, whenever it sees anything, tries to" +"predict that object’s motion into the future. So when looking at a robot +that appears to be human, the brain predicts that it will move like a +human. But when the robot moves like a machine, there is a mismatch, +which makes us uncomfortable. In particular, the parietal lobe lights up +(specifically, the part of the lobe where the motor cortex connects with +the visual cortex). It is believed that mirror neurons exist in this area of +the parietal lobe. This makes sense, because the visual cortex picks up +the image of the humanlike robot, and its motions are predicted via the +motor cortex and by mirror neurons. Finally, it is likely that the +orbitofrontal cortex, located right behind the eyes, puts everything +together and says, “Hmmm, something is not quite right.”" +"Hollywood filmmakers are aware of this effect. When spending +millions on making a horror movie, they realize that the scariest scene is +not when a gigantic blob or Frankenstein’s monster pounces out of the +bushes. The scariest scene is when there is a perversion of the ordinary. +Think of the movie The Exorcist What scene made moviegoers vomit as +they ran to escape the theater or faint right in their seats? Was it the +scene when a demon appears? No. Theaters across the world erupted in +shrill screams and loud sobs when Linda Blair turned her head +completely around." +"This effect can also be demonstrated in young monkeys. If you show +them pictures of Dracula or Frankenstein, they simply laugh and rip the +pictures apart. But what sends these young monkeys screaming in terror +is a picture of a decapitated monkey. Once again, it is the perversion of +the ordinary that elicits the greatest fear. (In Chapter 2, we mentioned +that the space-time theory of consciousness explains the nature of +humor, since the brain simulates the future of a joke, and then is +surprised to hear the punch line. This also explains the nature of horror. +The brain simulates the future of an ordinary, mundane event, but then + + is shocked when things suddenly become horribly perverted.) + +For this reason, robots will continue to look somewhat childlike in +appearance, even as they approach human intelligence. Only when +robots can act realistically like humans will their designers make them +look fully human. + +SILICON CONSCIOUSNESS" +"SILICON CONSCIOUSNESS + +As we’ve seen, human consciousness is an imperfect patchwork of +different abilities developed over millions of years of evolution. Given +information about their physical and social world, robots may be able to +create simulations similar (or in some respects, even superior) to ours, +but silicon consciousness might differ from ours in two key areas: +emotions and goals. + +Historically, AI researchers ignored the problem of emotions, +considering it a secondary issue. The goal was to create a robot that was +logical and rational, not scatterbrained and impulsive. Hence, the +science fiction of the 1950s and ’60s stressed robots (and humanoids like +Spock on Star Trek ) that had perfect, logical brains." +"We saw with the uncanny valley that robots will have to look a certain +way if they’re to enter our homes, but some people argue that robots +must also have emotions so that we can bond with, take care of, and +interact productively with them. In other words, robots will need Level II +consciousness. To accomplish this, robots will first have to recognize the +full spectrum of human emotions. By analyzing subtle facial movements +of the eyebrows, eyelids, lips, cheeks, etc., a robot will be able to +identify the emotional state of a human, such as its owner. One +institution that has excelled in creating robots that recognize and mimic +emotion is the MIT Media Laboratory. I have had the pleasure of visiting +the laboratory, outside Boston, on several occasions, and it is like +visiting a toy factory for grown-ups. Everywhere you look, you see +futuristic, high-tech devices designed to make our lives more interesting, +enjoyable, and convenient." +"As I looked around the room, I saw many of the high-tech graphics +that eventually found their way into Hollywood movies like Minority +Report and AI. As I wandered through this playground of the future, I +came across two intriguing robots, Huggable and Nexi. Their creator, Dr. +Cynthia Breazeal, explained to me that these robots have specific goals. +Huggable is a cute teddy bear-like robot that can bond with children. It +can identify the emotions of children; it has video cameras for eyes, a +speaker for its mouth, and sensors in its skin (so it can tell when it is +being tickled, poked, or hugged). Eventually, a robot like this might +become a tutor, babysitter, nurse’s aide, or a playmate. + + Nexi, on the other hand, can bond with adults. It looks a little like the +Pillsbury Doughboy. It has a round, puffy, friendly face, with large eyes" +"that can roll around. It has already been tested in a nursing home, and +the elderly patients all loved it. Once the seniors got accustomed to Nexi, +they would kiss it, talk to it, and miss it when it had to leave. (See +Figure 12.) + +Dr. Breazeal told me she designed Huggable and Nexi because she was +not satisfied with earlier robots, which looked like tin cans full of wires, +gears, and motors. In order to design a robot that could interact +emotionally with people, she needed to figure out how she could get it +to perform and bond like us. Plus, she wanted robots that weren’t stuck +on a laboratory shelf but could venture out into the real world. The +former director of MIT’s Media Lab, Dr. Frank Moss, says, “That is why +Breazeal decided in 2004 that it was time to create a new generation of +social robots that could live anywhere: homes, schools, hospitals, elder +care facilities, and so on.”" +"At Waseda University in Japan, scientists are working on a robot that +has upper-body motions representing emotions (fear, anger, surprise, +joy, disgust, sadness) and can hear, smell, see, and touch. It has been +programmed to carry out simple goals, such as satisfying its hunger for +energy and avoiding dangerous situations. Their goal is to integrate the +senses with the emotions, so that the robot acts appropriately in +different situations. + +Figure 12. Huggable (top) and Nexi (bottom), two robots built at the MIT Media Laboratory that were +explicitly designed + +to interact with humans via emotions, (illustration credit 10.1) + +(illustration credit 10.2) + +Not to be outdone, the European Commission is funding an ongoing +project, called Feelix Growing, which seeks to promote artificial +intelligence in the UK, France, Switzerland, Greece, and Denmark. + +EMOTIONAL ROBOTS + + Meet Nao." +"EMOTIONAL ROBOTS + + Meet Nao. + +When he’s happy, he will stretch out his arms to greet you, wanting a +big hug. When he’s sad, he turns his head downward and appears +forlorn, with his shoulders hunched forward. When he’s scared, he +cowers in fear, until someone pats him reassuringly on the head. + +He’s just like a one-year-old boy, except that he’s a robot. Nao is about +one and a half feet tall, and looks very much like some of the robots you +see in a toy store, like the Tranformers, except he’s one of the most +advanced emotional robots on earth. He was built by scientists at the + +UK’s University of Hertfordshire, whose research was funded by the +European Union. + +His creators have programmed him to show emotions like happiness, +sadness, fear, excitement, and pride. While other robots have +rudimentary facial and verbal gestures that communicate their emotions, +Nao excels in body language, such as posture and gesture. Nao even +dances." +"Unlike other robots, which specialize in mastering just one area of the +emotions, Nao has mastered a wide range of emotional responses. First, +Nao locks onto visitors’ faces, identifies them, and remembers his +previous interactions with each of them. Second, he begins to follow +their movements. For example, he can follow their gaze and tell what +they are looking at. Third, he begins to bond with them and learns to +respond to their gestures. For example, if you smile at him, or pat him +on his head, he knows that this is a positive sign. Because his brain has +neural networks, he learns from interactions with humans. Fourth, Nao +exhibits emotions in response to his interactions with people. (His +emotional responses are all preprogrammed, like a tape recorder, but he +decides which emotion to choose to fit the situation.) And lastly, the +more Nao interacts with a human, the better he gets at understanding +the moods of that person and the stronger the bond becomes." +"Not only does Nao have a personality, he can actually have several of +them. Because he learns from his interactions with humans and each +interaction is unique, eventually different personalities begin to emerge. +For example, one personality might be quite independent, not requiring +much human guidance. Another personality might be timid and fearful, +scared of objects in a room, constantly requiring human intervention. + +The project leader for Nao is Dr. Lola Canamero, a computer scientist +at the University of Hertfordshire. To start this ambitious project, she +analyzed the interactions of chimpanzees. Her goal was to reproduce, as +closely as she could, the emotional behavior of a one-year-old + + chimpanzee." +"chimpanzee. + +She sees immediate applications for these emotional robots. Like Dr. +Breazeal, she wants to use these robots to relieve the anxiety of young +children who are in hospitals. She says, “We want to explore different +roles—the robots will help the children to understand their treatment, +explain what they have to do. We want to help the children to control + +their anxiety.” + +Another possibility is that the robots will become companions at +nursing homes. Nao could become a valuable addition to the staff of a +hospital. At some point, robots like these might become playmates to +children and a part of the family." +"“It’s hard to predict the future, but it won’t be too long before the +computer in front of you will be a social robot. You’ll be able to talk to +it, flirt with it, or even get angry and yell at it—and it will understand +you and your emotions,” says Dr. Terrence Sejnowski of the Salk +Institute, near San Diego. This is the easy part. The hard part is to gauge +the response of the robot, given this information. If the owner is angry +or displeased, the robot has to be able to factor this into its response. + +EMOTIONS: DETERMINING WHAT IS IMPORTANT" +"EMOTIONS: DETERMINING WHAT IS IMPORTANT + +What’s more, AI researchers have begun to realize that emotions may be +a key to consciousness. Neuroscientists like Dr. Antonio Damasio have +found that when the link between the prefrontal lobe (which governs +rational thought) and the emotional centers (e.g., the limbic system) is +damaged, patients cannot make value judgments. They are paralyzed +when making the simplest of decisions (what things to buy, when to set +an appointment, which color pen to use) because everything has the +same value to them. Hence, emotions are not a luxury; they are +absolutely essential, and without them a robot will have difficulty +determining what is important and what is not. So emotions, instead of +being peripheral to the progress of artificial intelligence, are now +assuming central importance." +"If a robot encounters a raging fire, it might rescue the computer files +first, not the people, since its programming might say that valuable +documents cannot be replaced but workers always can be. It is crucial +that robots be programmed to distinguish between what is important +and what is not, and emotions are shortcuts the brain uses to rapidly +determine this. Robots would thus have to be programmed to have a +value system—that human life is more important than material objects, + + that children should be rescued first in an emergency, that objects with a +higher price are more valuable than objects with a lower price, etc. Since + +robots do not come equipped with values, a huge list of value judgments +must be uploaded into them." +"The problem with emotions, however, is that they are sometimes +irrational, while robots are mathematically precise. So silicon +consciousness may differ from human consciousness in key ways. For +example, humans have little control over emotions, since they happen so +rapidly and because they originate in the limbic system, not the +prefrontal cortex of the brain. Furthermore, our emotions are often +biased. Numerous tests have shown that we tend to overestimate the +abilities of people who are handsome or pretty. Good-looking people +tend to rise higher in society and have better jobs, although they may +not be as talented as others. As the expression goes, “Beauty has its +privileges.”" +"Similarly, silicon consciousness may not take into account subtle cues +that humans use when they meet one another, such as body language. +When people enter a room, young people usually defer to older ones and +low-ranked staff members show extra courtesy to senior officials. We +show our deference in the way we move our bodies, our choice of words, +and our gestures. Because body language is older than language itself, it +is hardwired into the brain in subtle ways. Robots, if they are to interact +socially with people, will have to learn these unconscious cues. + +Our consciousness is influenced by peculiarities in our evolutionary +past, which robots will not have, so silicon consciousness may not have +the same gaps or quirks as ours. + +A MENU OF EMOTIONS + +Since emotions have to be programmed into robots from the outside, +manufacturers may offer a menu of emotions carefully chosen on the +basis of whether they are necessary, useful, or will increase bonding +with the owner." +"In all likelihood, robots will be programmed to have only a few +human emotions, depending on the situation. Perhaps the emotion most +valued by the robot’s owner will be loyalty. One wants a robot that +faithfully carries out its commands without complaints, that understands +the needs of the master and anticipates them. The last thing an owner + + will want is a robot with an attitude, one that talks back, criticizes +people, and whines. Helpful criticisms are important, but they must be +made in a constructive, tactful way. Also, if humans give it conflicting +commands, the robot should know to ignore all of them except those +coming from its owner. + +Empathy will be another emotion that will be valued by the owner. +Robots that have empathy will understand the problems of others and +will come to their aid. By interpreting facial movements and listening to +tone of voice, robots will be able to identify when a person is in distress +and will provide assistance when possible." +"Strangely, fear is another emotion that is desirable. Evolution gave us +the feeling of fear for a reason, to avoid certain things that are +dangerous to us. Even though robots will be made of steel, they should +fear certain things that can damage them, like falling off tall buildings or +entering a raging fire. A totally fearless robot is a useless one if it +destroys itself. + +But certain emotions may have to be deleted, forbidden, or highly +regulated, such as anger. Given that robots could be built to have great +physical strength, an angry robot could create tremendous problems in +the home and workplace. Anger could get in the way of its duties and +cause great damage to property. (The original evolutionary purpose of +anger was to show our dissatisfaction. This can be done in a rational, +dispassionate way, without getting angry.)" +"Another emotion that should be deleted is the desire to be in +command. A bossy robot will only make trouble and might challenge the +judgment and wishes of the owner. (This point will also be important +later, when we discuss whether robots will one day take over from +humans.) Hence the robot will have to defer to the wishes of the owner, +even if this may not be the best path. + +But perhaps the most difficult emotion to convey is humor, which is a +glue that can bond total strangers together. A simple joke can defuse a +tense situation or inflame it. The basic mechanics of humor are simple: +they involve a punch line that is unanticipated. But the subtleties of +humor can be enormous. In fact, we often size up other people on the +basis of how they react to certain jokes. If humans use humor as a gauge +to measure other humans, then one can appreciate the difficulty of +creating a robot that can tell if a joke is funny or not. President Ronald" +"Reagan, for example, was famous for defusing the most difficult +questions with a quip. In fact, he accumulated a large card catalog of +jokes, barbs, and wisecracks, because he understood the power of + + humor. (Some pundits concluded that he won the presidential debate +against Walter Mondale when he was asked if he was too old to be +president. Reagan replied that he would not hold the youth of his +opponent against him.) Also, laughing inappropriately could have +disastrous consequences (and is, in fact, sometimes a sign of mental +illness). The robot has to know the difference between laughing with or +at someone. (Actors are well aware of the diverse nature of laughter. +They are skilled enough to create laughter that can represent horror, +cynicism, joy, anger, sadness, etc.) So, at least until the theory of +artificial intelligence becomes more developed, robots should stay away +from humor and laughter. + +PROGRAMMING EMOTIONS" +"PROGRAMMING EMOTIONS + +In this discussion we have so far avoided the difficult question of +precisely how these emotions would be programmed into a computer. +Because of their complexity, emotions will probably have to be +programmed in stages. + +First, the easiest part is identifying an emotion by analyzing the +gestures in a person’s face, lips, eyebrows, and tone of voice. Today’s +facial recognition technology is already capable of creating a dictionary +of emotions, so that certain facial expressions mean certain things. This +process actually goes back to Charles Darwin, who spent a considerable +amount of time cataloging emotions common to animals and humans. + +Second, the robot must respond rapidly to this emotion. This is also +easy. If someone is laughing, the robot will grin. If someone is angry, the +robot will get out of his way and avoid conflict. The robot would have a +large encyclopedia of emotions programmed into it, and hence would +know how to make a rapid response to each one." +"The third stage is perhaps the most complex because it involves trying +to determine the underlying motivation behind the original emotion. +This is difficult, since a variety of situations can trigger a single emotion. +Laughter may mean that someone is happy, heard a joke, or watched + +someone fall. Or it might mean that a person is nervous, anxious, or +insulting someone. Likewise, if someone is screaming, there may be an +emergency, or perhaps someone is just reacting with joy and surprise. +Determining the reason behind an emotion is a skill that even humans +have difficulty with. To do this, the robot will have to list the various +possible reasons behind an emotion and try to determine the reason that +makes the most sense. This means trying to find a reason behind the +emotion that fits the data best." +"And fourth, once the robot has determined the origin of this emotion, +it has to make the appropriate response. This is also difficult, since there +are often several possible responses, and the wrong one may make the +situation worse. The robot already has, within its programming, a list of +possible responses to the original emotion. It has to calculate which one +will best serve the situation, which means simulating the future. + +WILL ROBOTS LIE? + +Normally, we might think of robots as being coldly analytical and +rational, always telling the truth. But once robots become integrated into +society, they will probably have to learn to lie or at least tactfully +restrain their comments." +"In our own lives, several times in a typical day we are confronted with +situations where we have to tell a white lie. If people ask us how they +look, we often dare not tell the truth. White lies, in fact, are like a grease +that makes society run smoothly. If we were suddenly forced to tell the +whole truth (like Jim Carrey in Liar Liar), we most likely would wind up +creating chaos and hurting people. People would be insulted if you told +them what they really looked like or how you really felt. Bosses would +fire you. Lovers would dump you. Friends would abandon you. Strangers +would slap you. Some thoughts are better kept confidential." +"In the same way, robots may have to learn how to lie or conceal the +truth, or else they might wind up offending people and being +decommissioned by their owners. At a party, if a robot tells the truth, it +could reflect badly on its owner and create an uproar. So if someone asks +for its opinion, it will have to learn how to be evasive, diplomatic, and +tactful. It must either dodge the question, change the subject, give + +platitudes for answers, reply with a question, or tell white lies (all things +that today’s chat-bots are increasingly good at). This means that the +robot has already been programmed to have a list of possible evasive +responses, and must choose the one that creates the fewest +complications." +"One of the few times that a robot would tell the entire truth would be +if asked a direct question by its owner, who understands that the answer +might be brutally honest. Perhaps the only other time when the robot +will tell the truth is when there is a police investigation and the absolute +truth is necessary. Other than that, robots will be able to freely lie or +conceal the whole truth to keep the wheels of society functioning. + + In other words, robots have to be socialized, just like teenagers. + +CAN ROBOTS FEEL PAIN? + +Robots, in general, will be assigned to do types of tasks that are dull, +dirty, and dangerous. There is no reason why robots can’t do repetitive +or dirty jobs indefinitely, since we wouldn’t program them to feel +boredom or disgust. The real problem emerges when robots are faced +with dangerous jobs. At that point, we might actually want to program +them to feel pain." +"We evolved the sense of pain because it helped us survive in a +dangerous environment. There is a genetic defect in which children are +born without the ability to feel pain. This is called congenital analgesia. +At first glance, this may seem to be a blessing, since these children do +not cry when they experience injury, but it is actually more of a curse. +Children with this affliction have serious problems, such as biting off +parts of their tongue, suffering severe skin burns, and cutting +themselves, often leading to amputations of their fingers. Pain alerts us +to danger, telling us when to move our hand away from the burning +stove or to stop running on a twisted ankle." +"At some point robots must be programmed to feel pain, or else they +will not know when to avoid precarious situations. The first sense of +pain they must have is hunger (i.e., a craving for electrical energy). As +their batteries run out, they will get more desperate and urgent, +realizing that soon their circuits will shut down, leaving all their work in + +disarray. The closer they are to running out of power, the more anxious +they will become. + +Also, regardless of how strong they are, robots may accidentally pick +up an object that is too heavy, which could cause their limbs to break. +Or they may suffer overheating by working with molten metal in a steel +factory, or by entering a burning building to help firemen. Sensors for +temperature and stress would alert them that their design specifications +are being exceeded." +"But once the sensation of pain is added to their menu of emotions, this +immediately raises ethical issues. Many people believe that we should +not inflict unnecessary pain on animals, and people may feel the same +about robots as well. This opens the door to robots’ rights. Laws may +have to be passed to restrict the amount of pain and danger that a robot +is allowed to face. People will not care if a robot is performing dull or +dirty tasks, but if they feel pain doing a dangerous one, they may begin + + to lobby for laws to protect robots. This may even start a legal conflict, +with owners and manufacturers of robots arguing for increasing the level +of pain that robots can endure, while ethicists may argue for lowering it." +"This, in turn, may set off other ethical debates about other robot +rights. Can robots own property? What happens if they accidentally hurt +someone? Can they be sued or punished? Who is responsible in a +lawsuit? Can a robot own another robot? This discussion raises another +sticky question: Should robots be given a sense of ethics? + +ETHICAL ROBOTS + +At first, the idea of ethical robots seems like a waste of time and effort. +However, this question takes on a sense of urgency when we realize that +robots will make life-and-death decisions. Since they will be physically +strong and have the capability of saving lives, they will have to make +split-second ethical choices about whom to save first." +"Let’s say there is a catastrophic earthquake and children are trapped in +a rapidly crumbling building. How should the robot allocate its energy? +Should it try to save the largest number of children? Or the youngest? Or +the most vulnerable? If the debris is too heavy, the robot may damage its +electronics. So the robot has to decide yet another ethical question: How + +does it weigh the number of children it saves versus the amount of +damage that it will sustain to its electronics? + +Without proper programming, the robot may simply halt, waiting for a +human to make the final decision, wasting valuable time. So someone +will have to program it ahead of time so that the robot automatically +makes the “right” decision." +"These ethical decisions will have to be preprogrammed into the +computer from the start, since there is no law of mathematics that can +put a value on saving a group of children. Within its programming, there +has to be a long list of things, ranked in terms of how important they +are. This is tedious business. In fact, it sometimes takes a human a +lifetime to learn these ethical lessons, but a robot has to learn them +rapidly, before it leaves the factory, if it is to safely enter society. + +Only people can do this, and even then ethical dilemmas sometimes +confound us. But this raises questions: Who will make the decisions? +Who decides the order in which robots save human lives? + +The question of how decisions will ultimately be made will probably" +"The question of how decisions will ultimately be made will probably + + be resolved via a combination of the law and the marketplace. Laws will +have to be passed so that there is, at minimum, a ranking of importance +of whom to save in an emergency. But beyond that, there are thousands +of finer ethical questions. These subtler decisions may be decided by the +marketplace and common sense. + +If you work for a security firm guarding important people, you will +have to tell the robot how to save people in a precise order in different +situations, based on considerations such as fulfilling the primary duty +but also doing it within budget." +"What happens if a criminal buys a robot and wants the robot to +commit a crime? This raises a question: Should a robot be allowed to +defy its owner if it is asked to break the law? We saw from the previous +example that robots must be programmed to understand the law and +also make ethical decisions. So if it decides that it is being asked to +break the law, it must be allowed to disobey its master. + +There is also the ethical dilemma posed by robots reflecting the beliefs +of their owners, who may have diverging morals and social norms. The +“culture wars” that we see in society today will only be magnified when +we have robots that reflect the opinions and beliefs of their owners. In +some sense, this conflict is inevitable. Robots are mechanical extensions + +of the dreams and wishes of their creators, and when robots are +sophisticated enough to make moral decisions, they will do so." +"The fault lines of society may be stressed when robots begin to exhibit +behaviors that challenge our values and goals. Robots owned by youth +leaving a noisy, raucus rock concert may conflict with robots owned by +elderly residents of a quiet neighborhood. The first set of robots may be +programmed to amplify the sounds of the latest bands, while the second +set may be programmed to keep noise levels to an absolute minimum. +Robots owned by devout, churchgoing fundamentalists may get into +arguments with robots owned by atheists. Robots from different nations +and cultures may be designed to reflect the mores of their society, which +may clash (even for humans, let alone robots). + +So how does one program robots to eliminate these conflicts?" +"So how does one program robots to eliminate these conflicts? + +You can’t. Robots will simply reflect the biases and prejudices of their +creators. Ultimately, the cultural and ethical differences between these +robots will have to be settled in the courts. There is no law of physics or +science that determines these moral questions, so eventually laws will +have to be written to handle these social conflicts. Robots cannot solve +the moral dilemmas created by humans. In fact, robots may amplify +them. + + But if robots can make ethical and legal decisions, can they also feel +and understand sensations? If they succeed in saving someone, can they +experience joy? Or can they even feel things like the color red? Coldly +analyzing the ethics of whom to save is one thing, but understanding +and feeling is another. So can robots feel? + +CAN ROBOTS UNDERSTAND OR FEEL?" +"CAN ROBOTS UNDERSTAND OR FEEL? + +Over the centuries, a great many theories have been advanced about +whether a machine can think and feel. My own philosophy is called +“constructivism”; that is, instead of endlessly debating the question, +which is pointless, we should be devoting our energy to creating an +automaton to see how far we can get. Otherwise we wind up in endless +philosophical debates that are never ultimately resolved. The advantage +of science is that, once everything is said and done, one can perform +experiments to settle a question decisively." +"Thus, to settle the question of whether a robot can think, the final +resolution may be to build one. Some, however, have argued that +machines will never be able to think like a human. Their strongest +argument is that, although a robot can manipulate facts faster than a +human, it does not “understand” what it is manipulating. Although it +can process senses (e.g., color, sound) better than a human, it cannot +truly “feel” or “experience” the essence of these senses. + +For example, philosopher David Chalmers has divided the problems of +AI into two categories, the Easy Problems and the Hard Problems. To +him, the Easy Problems are creating machines that can mimic more and +more human abilities, such as playing chess, adding numbers, +recognizing certain patterns, etc. The Hard Problems involve creating +machines that can understand feelings and subjective sensations, which +are called “qualia.”" +"Just as it is impossible to teach the meaning of the color red to a blind +person, a robot will never be able to experience the subjective sensation +of the color red, they say. Or a computer might be able to translate +Chinese words into English with great fluency, but it will never be able +to understand what it is translating. In this picture, robots are like +glorified tape recorders or adding machines, able to recite and +manipulate information with incredible precision, but without any +understanding whatsoever. + +These arguments have to be taken seriously, but there is also another +way of looking at the question of qualia and subjective experience. In" +"the future, a machine most likely will be able to process a sensation, +such as the color red, much better than any human. It will be able to +describe the physical properties of red and even use it poetically in a +sentence better than a human. Does the robot “feel” the color red? The +point becomes irrelevant, since the word “feel” is not well defined. At +some point, a robot’s description of the color red may exceed a human’s, +and the robot may rightly ask: Do humans really understand the color +red? Perhaps humans cannot really understand the color red with all the +nuances and subtly that a robot can. + +As behaviorist B. F. Skinner once said, “The real problem is not +whether machines think, but whether men do.” + +Similarly, it is only a matter of time before a robot will be able to +define Chinese words and use them in context much better than any" +"human. At that point, it becomes irrelevant whether the robot +“understands” the Chinese language. For all practical purposes, the +computer will know the Chinese language better than any human. In +other words, the word “understand” is not well defined. + +One day, as robots surpass our ability to manipulate these words and +sensations, it will become irrelevant whether the robot “understands” or +“feels” them. The question will cease to have any importance. + +As mathematician John von Neumann said, “In mathematics, you +don’t understand things. You just get used to them.” + +So the problem lies not in the hardware but in the nature of human +language, in which words that are not well defined mean different things +to different people. The great quantum physicist Niels Bohr was once +asked how one could understand the deep paradoxes of the quantum +theory. The answer, he replied, lies in how you define the word +“understand.”" +"Dr. Daniel Dennett, a philosopher at Tufts University, has written, +“There could not be an objective test to distinguish a clever robot from a +conscious person. Now you have a choice: you can either cling to the +Hard Problem, or you can shake your head in wonder and dismiss it. +Just let go.” + +In other words, there is no such thing as the Hard Problem. + +To the constructivist philosophy, the point is not to debate whether a +machine can experience the color red, but to construct the machine. In +this picture, there is a continuum of levels describing the words +“understand” and “feel.” (This means that it might even be possible to" +"give numerical values to the degree of understanding and feeling.) At +one end we have the clumsy robots of today, which can manipulate a +few symbols but not much more. At the other end we have humans, who +pride themselves on feeling qualia. But as time goes by, robots will +eventually be able to describe sensations better than us on any level. +Then it will be obvious that robots understand. + +This was the philosophy behind Alan Turing’s famous Turing test. He +predicted that one day a machine would be built that could answer any +question, so that it would be indistinguishable from a human. He said, +“A computer would deserve to be called intelligent if it could deceive a +human into believing that it was human.” + +Physicist and Nobel laureate Francis Crick said it best. In the last" +"Physicist and Nobel laureate Francis Crick said it best. In the last + +century, he noted, biologists had heated debates over the question “What +is life?” Now, with our understanding of DNA, scientists realize that the +question is not well defined. There are many variations, layers, and +complexities to that simple question. The question “What is life?” simply +faded away. The same may eventually apply to feeling and +understanding. + +SELF-AWARE ROBOTS + +What steps must be taken before computers like Watson have self- +awareness? To answer this question, we have to refer back to our +definition of self-awareness: the ability to put one’s self inside a model of +the environment, and then run simulations of this model into the future +to achieve a goal. This first step requires a very high level of common +sense in order to anticipate a variety of events. Then the robot has to put +itself inside this model, which requires an understanding of the various +courses of action it may take." +"At Meiji University, scientists have taken the first steps to create a +robot with self-awareness. This is a tall order, but they think they can do +it by creating robots with a Theory of Mind. They started by building +two robots. The first was programmed to execute certain motions. The +second was programmed to observe the first robot, and then to copy it. +They were able to create a second robot that could systematically mimic +the behavior of the first just by watching it. This is the first time in +history that a robot has been built specifically to have some sense of self- +awareness. The second robot has a Theory of Mind; that is, it is capable +of watching another robot and then mimicking its motions. + +In 2012, the next step was taken by scientists at Yale University who" +"In 2012, the next step was taken by scientists at Yale University who + + created a robot that passed the mirror test. When animals are placed in +front of a mirror, most of them think the image in the mirror is that of +another animal. As we recall, only a few animals have passed the mirror +test, realizing that the mirror image was a reflection of themselves. The +scientists at Yale created a robot called Nico that resembles a gangly +skeleton made of twisted wires, with mechanical arms and two bulging +eyes sitting on top. When placed in front of a mirror, Nico not only +recognized itself but could also deduce the location of objects in a room + +by looking at their images in the mirror. This is similar to what we do +when we look into a rearview mirror and infer the location of objects +behind us." +"Nico’s programmer, Justin Hart, says, “To our knowledge, this is the +first robotic system to attempt to use a mirror in this way, representing a +significant step towards a cohesive architecture that allows robots to +learn about their bodies and appearance through self-observation, and +an important capability required in order to pass the mirror test.” + +Because the robots at Meiji University and Yale University represent +the state of the art in terms of building robots with self-awareness, it is +easy to see that scientists have a long ways to go before they can create +robots with humanlike self-awareness. + +Their work is just the first step, because our definition of self- +awareness demands that the robot use this information to create +simulations of the future. This is far beyond the capability of Nico or any +other robot." +"This raises the important question: How can a computer gain full self- +awareness? In science fiction, we often encounter a situation where the +Internet suddenly becomes self-aware, as in the movie The Terminator. +Since the Internet is connected to the entire infrastructure of modern +society (e.g., our sewer system, our electricity, our telecommunications, +our weapons), it would be easy for a self-aware Internet to seize control +of society. We would be left helpless in this situation. Scientists have +written that this may happen as an example of an “emergent +phenomenon” (i.e., when you amass a sufficiently large number of +computers together, there can be a sudden phase transition to a higher +stage, without any input from the outside). + +However, this says everything and it says nothing, because it leaves +out all the important steps in between. It’s like saying that a highway +can suddenly become self-aware if there are enough roads." +"But in this book we have given a definition of consciousness and self- +awareness, so it should be possible to list the steps by which the Internet + + can become self-aware. + +First, an intelligent Internet would have to continually make models of +its place in the world. In principle, this information can be programmed +into the Internet from the outside. This would involve describing the +outside world (i.e., Earth, its cities, and its computers), all of which can + +be found on the Internet itself. + +Second, it would have to place itself in the model. This information is +also easily obtained. It would involve giving all the specifications of the +Internet (the number of computers, nodes, transmission lines, etc.) and +its relationship to the outside world." +"But step three is by far the most difficult. It means continually running +simulations of this model into the future, consistent with a goal. This is +where we hit a brick wall. The Internet is not capable of running +simulations into the future, and it has no goals. Even in the scientific +world, simulations into the future are usually done in just a few +parameters (e.g., simulating the collision of two black holes). Running a +simulation of the model of the world containing the Internet is far +beyond the programming available today. It would have to incorporate +all the laws of common sense, all the laws of physics, chemistry, and +biology, as well as facts about human behavior and human society. + +In addition, this intelligent Internet would have to have a goal. Today +it is just a passive highway, without any direction or purpose. Of course, +one can in principle impose a goal on the Internet. But let us consider +the following problem: Can you create an Internet whose goal is self- +preservation?" +"This would be the simplest possible goal, but no one knows how to +program even this simple task. Such a program, for example, would have +to stop any attempt to shut down the Internet by pulling the plug. At +present, the Internet is totally incapable of recognizing a threat to its +existence, let alone plotting ways to prevent it. (For example, an Internet +capable of detecting threats to its existence would have to be able to +identify attempts to shut down its power, cut lines of communication, +destroy its servers, disable its fiber-optic and satellite connections, etc. +Furthermore, an Internet capable of defending itself against these attacks +would have to have countermeasures for each scenario and then run +these attempts into the future. No computer on Earth is capable of doing +even a fraction of such things.) + +In other words, one day it may be possible to create self-aware robots, +even a self-aware Internet, but that day is far into the future, perhaps at +the end of this century." +"But assume for the moment that the day has arrived, that self-aware +robots walk among us. If a self-aware robot has goals that are + +compatible with our own, then this type of artificial intelligence will not +pose a problem. But what happens if the goals are different? The fear is +that humans may be outwitted by self-aware robots and then may be +enslaved. Because of their superior ability to simulate the future, the +robots could plot the outcomes of many scenarios to find the best way to +overthrow humanity. + +One way this possibility may be controlled is to make sure that the +goals of these robots are benevolent. As we have seen, simulating the +future is not enough. These simulations must serve some final goal. If a +robot’s goal is merely to preserve itself, then it would react defensively +to any attempt to pull the plug, which could spell trouble for mankind. + +WILL ROBOTS TAKE OVER?" +"WILL ROBOTS TAKE OVER? + +In almost all science-fiction tales, the robots become dangerous because +of their desire to take over. The word “robot,” in fact, comes from the +Czech word for “worker,” first seen in the 1920 play R.U.R. (Rossum’s +Universal Robots) by Karel Capek, in which scientists create a new race of +mechanical beings that look identical to humans. Soon there are +thousands of these robots performing menial and dangerous tasks. +However, humans mistreat them badly, and one day they rebel and +destroy the human race. Although these robots have taken over Earth, +they have one defect: they cannot reproduce. But at the end of the play, +two robots fall in love. So perhaps a new branch of “humanity” emerges +once again." +"A more realistic scenario comes from the movie The Terminator, in +which the military has created a supercomputer network called Skynet +that controls the entire U.S. nuclear stockpile. One day, it wakes up and +becomes sentient. The military tries to shut down Skynet but then +realizes there is a flaw in its programming: it is designed to protect itself, +and the only way to do so is by eliminating the problem—humanity. It +starts a nuclear war, which reduces humanity to a ragtag bunch of +misfits and rebels fighting the juggernaut of the machines. + +It is certainly possible that robots could become a threat. The current +Predator drone can target its victims with deadly accuracy, but it is +controlled by someone with a joystick thousands of miles away." +"According to the New York Times, the orders to fire come directly from +the president of the United States. But in the future, a Predator might +have face recognition technology and permission to fire if it is 99 +percent confident of the identity of its target. Without human +intervention, it could automatically use this technology to fire at anyone +who fits the profile. + +Now assume that such a drone suffers a breakdown, such that its facial +recognition software malfunctions. Then it becomes a rogue robot, with +permission to kill anyone in sight. Worse, imagine a fleet of such robots +controlled by a central command. If a single transistor were to blow out +in this central computer and malfunction, then the entire fleet might go +on a killing spree." +"A more subtle problem is when robots perform perfectly well, without +any malfunctions, yet there is a tiny but fatal flaw in their programming +and goals. For a robot, self-preservation is one important goal. But so is +being helpful to humans. The real problem arises when these goals +contradict each other. + +In the movie 1 , Robot, the computer system decides that humans are +self-destructive, with their never-ending wars and atrocities, and that the +only way to protect the human race is to take over and create a +benevolent dictatorship of the machine. The contradiction here is not +between two goals, but within a single goal that is not realistic. These +murderous robots do not malfunction—they logically conclude that the +only way to preserve humanity is to take control of society." +"One solution to this problem is to create a hierarchy of goals. For +example, the desire to help humans must outrank self-preservation. This +theme was explored in the movie 2001 . The computer system HAL 9000 +was a sentient computer capable of conversing easily with humans. But +the orders given to HAL 9000 were self-contradictory and could not be +logically carried out. By attempting to execute an impossible goal, it fell +off the mesa; it went crazy, and the only solution to obeying +contradictory commands from imperfect humans was to eliminate the +humans. + +The best solution might be to create a new law of robotics, which +would state that robots cannot do harm to the human race, even if there +are contradictions within their previous directives. They must be +programmed to ignore lower-level contradictions within their orders and" +"always preserve the supreme law. But this might still be an imperfect +system at best. (For example, if the robots’ central goal is to protect +humanity to the exclusion of all other goals, then it all depends on how + + the robots define the word “protect.” Their mechanical definition of this +word may differ from ours.) + +Instead of reacting with terror, some scientists, such as Dr. Douglas +Hofstadter, a cognitive scientist at Indiana University, do not fear this +possibility. When I interviewed him, he told me that robots are our +children, so why shouldn’t we love them like our own? His attitude, he +told me, is that we love our children, even though we know that they +will take over." +"When I interviewed Dr. Hans Moravec, former director of the AI +Laboratory at Carnegie Mellon University, he agreed with Dr. Hofstadter. +In his book Robot, he writes, “Unleashed from the plodding pace of +biological evolution, the children of our minds will be free to grow to +confront immense and fundamental challenges in the larger universe. +... We humans will benefit for a time from their labors, but ... like +natural children, they will seek their own fortunes, while we, their aged +parents, silently fade away.” + +Others, on the contrary, think that this is a horrible solution. Perhaps +the problem can be solved if we make changes in our goals and priorities +now, before it is too late. Since these robots are our children, we should +“teach” them to be benevolent. + +FRIENDLY AI" +"FRIENDLY AI + +Robots are mechanical creatures that we make in the laboratory, so +whether we have killer robots or friendly robots depends on the +direction of AI research. Much of the funding comes from the military, +which is specifically mandated to win wars, so killer robots are a definite +possibility. + +However, since 30 percent of all commercial robots are manufactured +in Japan, there is another possibility: robots will be designed to become +helpful playmates and workers from the very beginning. This goal is +feasible if the consumer sector dominates robotics research. The +philosophy of “friendly AI” is that inventors should create robots that, + +from the very first steps, are programmed to be beneficial to humans." +"from the very first steps, are programmed to be beneficial to humans. + +Culturally, the Japanese approach to robots is different from the +West’s. While kids in the West might feel terror watching rampaging +Terminatortype robots, kids in Japan are steeped in the Shinto religion, +which believes spirits live in all things, even mechanical robots. Instead +of being uncomfortable at the sight of robots, Japanese children squeal" +"with delight upon encountering them. It’s no wonder, therefore, that +these robots in Japan are proliferating in the marketplace and in homes. +They greet you at department stores and educate you on TV. There is +even a serious play in Japan featuring a robot. (Japan has another +reason for embracing robots. These are the future robot nurses for an +aging country. Twenty-one percent of the population is over sixty-five, +and Japan is aging faster than any other nation. In some sense, Japan is +a train wreck in slow motion. Three demographic factors are at work. +First, Japanese women have the longest life expectancy of any ethnic +group in the world. Second, Japan has one of the world’s lowest +birthrates. Third, it has a strict immigration policy, with over 99 percent +of the population being pure Japanese. Without young immigrants to +take care of the elderly, Japan may rely on robot nurses. This problem is +not restricted to Japan; Europe is next. Italy, Germany, Switzerland, and" +"not restricted to Japan; Europe is next. Italy, Germany, Switzerland, and +other European nations face similar demographic pressures. The +populations of Japan and Europe could experience severe shrinkage by +mid-century. The United States is not far behind. The birthrate of native- +born U.S. citizens has also fallen dramatically in the last few decades, +but immigration will keep the United States expanding into this century. +In other words, it could be a trilliondollar gamble to see if robots can +save us from these three demographic nightmares.)" +"Japan leads the world in creating robots that can enter our personal +lives. The Japanese have built robots that can cook (one can make a +bowl of noodles in a minute and forty seconds). When you go to a +restaurant, you can place your order on a tablet computer and the robot +cook springs into action. It consists of two large, mechanical arms, which +grab the bowls, spoons, and knives and prepare the food for you. Some +robotic cooks even resemble human ones. + +There are also musical robots for entertainment. One such robot +actually has accordion-like “lungs” by which it can generate music by +pumping air through an instrument. There are also robot maids. If you" +"carefully prepare your laundry, it can fold it in front of you. There is +even a robot that can talk because it has artificial lungs, lips, tongue, +and nasal cavity. The Sony Corporation, for example, built the AIBO +robot, which resembles a dog and can register a number of emotions if +you pet it. Some futurists predict that the robotics industry may one day +become as large as the automobile industry is today. + +The point here is that robots are not necessarily programmed to +destroy and dominate. The future of AI is up to us. + +But some critics of friendly AI claim that robots may take over not +because they are aggressive, but because we are sloppy in creating them. +In other words, if the robots take over, it will be because we + + programmed them to have conflicting goals. + +“I AM A MACHINE”" +"programmed them to have conflicting goals. + +“I AM A MACHINE” + +When I interviewed Dr. Rodney Brooks, former director of the MIT +Artificial Intelligence Lab and cofounder of iRobot, I asked him if he +thought machines would one day take over. He told me that we just +have to accept that we are machines ourselves. This means that one day, +we will be able to build machines that are just as alive as we are. But, he +cautioned, we will have to give up the concept of our “specialness.” + +This evolution in human perspective started with Nicolaus Copernicus +when he realized that the Earth was not the center of the universe, but +rather goes around the sun. It continued with Darwin, who showed that +we were similar to the animals in our evolution. And it will continue +into the future, he told me, when we realize that we are machines, +except that we are made of wetware and not hardware." +"It’s going to represent a major change in our world outlook to accept +that we, too, are machines, he believes. He writes, “We don’t like to give +up our specialness, so you know, having the idea that robots could really +have emotions, or that robots could be living creatures—I think is going +to be hard for us to accept. But we’re going to come to accept it over the +next fifty years.” + +But on the question of whether the robots will eventually take over, he +says that this will probably not happen, for a variety of reasons. First, no +one is going to accidentally build a robot that wants to rule the world. + +He says that creating a robot that can suddenly take over is like someone +accidentally building a 747 jetliner. Plus, there will be plenty of time to +stop this from happening. Before someone builds a “super-bad robot,” +someone has to build a “mildly bad robot,” and before that a “not-so-bad +robot.”" +"His philosophy is summed up when he says, “The robots are coming, +but we don’t have too much to worry about. It’s going to be a lot of fun.” +To him, the robot revolution is a certainty, and he foresees the day when +robots will surpass human intelligence. The only question is when. But +there is nothing to fear, since we will have created them. We have the +choice to create them to help, and not hinder, us. + +MERGE WITH THEM? + + If you ask Dr. Brooks how we can coexist with these super-smart robots, +his reply is straightforward: we will merge with them. With advances in +robotics and neuroprosthetics, it becomes possible to incorporate AI into +our own bodies. + +Dr. Brooks notes that the process, in some sense, has already begun. +Today, about twenty thousand people have had cochlear implants, +which have given them the gift of hearing. Sounds are picked up by a +tiny receiver, which converts sound waves to electrical signals, which +are then sent directly to the auditory nerves of the ear." +"Similarly, at the University of Southern California and elsewhere, it is +possible to take a patient who is blind and implant an artificial retina. +One method places a mini video camera in eyeglasses, which converts an +image into digital signals. These are sent wirelessly to a chip placed in +the person’s retina. The chip activates the retina’s nerves, which then +send messages down the optic nerve to the occipital lobe of the brain. In +this way, a person who is totally blind can see a rough image of familiar +objects. Another design has a light-sensitive chip placed on the retina +itself, which then sends signals directly to the optic nerve. This design +does not need an external camera. + +This also means that we can go even further and enhance ordinary +senses and abilities. With cochlear implants, it will be possible to hear +high frequencies that we have never heard before. Already with infrared" +"glasses, one can see the specific type of light that emanates from hot +objects in the dark and that is normally invisible to the human eye. With +artificial retinas, it may be possible to enhance our ability to see +ultraviolet or infrared light. (Bees, for example, can see UV light because +they have to lock onto the sun in order to navigate to a flower bed.) + +Some scientists even dream of the day when exoskeletons will have +superpowers like those found in comic books, with super strength, super +senses, and super abilities. We’d become a cyborg like Iron Man, a +normal human with superhuman abilities and powers. This means that +we might not have to worry about super-intelligent robots taking over. +We’d simply merge with them." +"This, of course, is for the distant future. But some scientists, frustrated +that robots are not leaving the factory and entering our lives, point out +that Mother Nature has already created the human mind, so why not +copy it? Their strategy is to take the brain apart, neuron by neuron, and +then reassemble it. + +But reverse engineering entails more than just creating a vast + + blueprint to create a living brain. If the brain can be duplicated down to +the last neuron, perhaps we can upload our consciousness into a +computer. We’d have the ability to leave our mortal bodies behind. This +is beyond mind over matter. This is mind without matter. + +I’m as fond of my body as anyone, but if I can be 200 with a +body of silicon, I’ll take it. + +—DANIEL HILL, COFOUNDER OF THINKING MACHINES CORP. + +11 REVERSE ENGINEERING THE BRAIN" +"—DANIEL HILL, COFOUNDER OF THINKING MACHINES CORP. + +11 REVERSE ENGINEERING THE BRAIN + +In January 2013, two bombshells were dropped that could alter the +medical and scientific landscape forever. Overnight, reverse engineering +the brain, once considered to be too complex to solve, suddenly became +a focal point of scientific rivalry and pride between the greatest +economic powers on Earth." +"First, in his State of the Union address, President Barack Obama +stunned the scientific community by announcing that federal research +funds, perhaps to the tune of $3 billion, might be allocated to the Brain +Research Through Advancing Innovative Neurotechnologies (or BRAIN) +Initiative. Like the Human Genome Project, which opened the floodgates +for genetic research, BRAIN will pry open the secrets of the brain at the +neural level by mapping its electrical pathways. Once the brain is +mapped, a host of intractable diseases like Alzheimer’s, Parkinson’s, +schizophrenia, dementia, and bipolar disorder might be understood and +possibly cured. To jump-start BRAIN, $100 million might be allocated in +2014 toward the project." +"Almost simultaneously, the European Commission announced that the +Human Brain Project would be awarded 1.19 billion euros (about $1.6 +billion) to create a computer simulation of the human brain. Using the +power of the biggest supercomputers on the planet, the Human Brain +Project will create a copy of the human brain made of transistors and +steel. + +Proponents of both projects stressed the enormous benefits of these +endeavors. President Obama was quick to point out that not only would +BRAIN alleviate the suffering of millions of people, it will also generate +new revenue streams. For every dollar spent on the Human Genome +Project, he claimed, about $140 of economic activity was generated. +Entire industries, in fact, sprouted with the completion of the Human +Genome Project. For the taxpayer, BRAIN, like the Human Genome + + Project, will be a win-win situation." +"Project, will be a win-win situation. + +Although Obama’s speech did not give details, scientists quickly filled +in many of the gaps. Neurologists pointed out that, on one hand, it is +now possible to use delicate instruments to monitor the electrical +activity of single neurons. On the other hand, using MRI machines, it is +possible to monitor the global behavior of the entire brain. What is +missing, they pointed out, is the middle ground, where most of the +interesting brain activity takes place. It is in this middle ground, +involving the pathways of thousands to millions of neurons, that there +are huge gaps in our understanding of mental disease and behavior." +"To tackle this enormous problem, scientists laid out a tentative fifteen- +year program. In the first five years, neurologists hope to monitor the +electrical activity of tens of thousands of neurons. The short-term goals +might include reconstructing the electrical activity of important parts of +animal brains, such as the medulla of the Drosophila fruit fly or the +ganglion cells in a mouse retina (which has fifty thousand neurons). + +Within ten years, that number should increase to hundreds of +thousands of neurons. This could include imaging the entire Drosophila +brain (135,000 neurons) or even the cortex of the Etruscan shrew, the +smallest known mammal, with a million neurons. + +Finally, within fifteen years, it should be possible to monitor millions +of neurons, comparable to the zebrafish brain or the entire neocortex of +a mouse. This could pave the way toward imaging parts of the brains of +primates." +"Meanwhile, in Europe, the Human Brain Project would tackle the +problem from a different point of view. Over a ten-year period, it will +use supercomputers to simulate the basic functioning of the brains of +different animals, starting with mice and working up to humans. Instead +of dealing with individual neurons, the Human Brain Project will use +transistors to mimic their behavior, so that there will be computer +modules that can act like the neocortex, the thalamus, and other parts of +the brain. + +In the end, the rivalry between these two gigantic projects could +create a windfall by generating new discoveries for treating incurable +diseases and spawning new industries. But there is also another, unstated +goal. If one can eventually simulate a human brain, does it mean that +the brain can become immortal? Does it mean that consciousness can +now exist outside the body? Some of the thorniest theological and + + metaphysical questions are raised by these ambitious projects. + +BUILDING A BRAIN" +"metaphysical questions are raised by these ambitious projects. + +BUILDING A BRAIN + +Like many other children, I used to love taking apart clocks, +disassembling them, screw for screw, and then trying to see how the +whole thing fit together. I would trace each part mentally, seeing how +one gear connected to the next one, until the whole thing fit together. I +realized the mainspring turned the main gear, which then fed a sequence +of smaller gears, which eventually turned the hands of the clock. + +Today, on a much larger scale, computer scientists and neurologists +are trying to take apart an infinitely more complex object, the most +sophisticated object we know about in the universe: the human brain. +Moreover, they wish to reassemble it, neuron by neuron." +"Because of rapid advances in automation, robotics, nanotechnology, +and neuroscience, reverse engineering the human brain is no longer idle +speculation for polite after-dinner banter. In the United States and +Europe, billions of dollars will soon be flowing into projects once +considered preposterous. Today a small band of visionary scientists are +dedicating their professional lives to a project that they may not live to +see completed. Tomorrow their ranks could swell into an entire army, +generously funded by the United States and the nations of Europe. + +If successful, these scientists could alter the course of human history. +Not only might they find new cures and therapies for mental illnesses, +they might also unlock the secret of consciousness and perhaps upload it +into a computer." +"It is a daunting task. The human brain consists of over one hundred +billion neurons, approximately as many stars as there are in the Milky +Way galaxy. Each neuron, in turn, is connected to perhaps ten thousand +other neurons, so altogether there are a total of ten million billion +possible connections (and that does not begin to compute the number of +pathways there are among this thicket of neurons). The number of +“thoughts” that a human brain can conceive of is therefore truly +astronomical and beyond human ken. + +Yet that has not stopped a small bunch of fiercely dedicated scientists +from attempting to reconstruct the brain from scratch. There is an old + +Chinese proverb, “A journey of a thousand miles begins with the first +step.” That first step was actually taken when scientists decoded, neuron +for neuron, the nervous system of a nematode worm. This tiny creature," +"called C. elegans, has 302 neurons and 7,000 synapses, all of which have +been precisely recorded. A complete blueprint of its nervous system can +be found on the Internet. (Even today, it is the only living organism to +have its entire neural structure decoded in this way.) + +At first, it was thought that the complete reverse engineering of this +simple organism would open the door to the human brain. Ironically, the +opposite has happened. Although the nematode’s neurons were finite in +number, the network is still so complex and sophisticated that it has +taken years to understand even simple facts about worm behavior, such +as which pathways are responsible for which behaviors. If even the +lowly nematode worm could elude our scientific understanding, +scientists were forced to appreciate how complex a human brain must +be. + +THREE APPROACHES TO THE BRAIN" +"THREE APPROACHES TO THE BRAIN + +Because the brain is so complex, there are at least three distinct ways in +which it can be taken apart, neuron by neuron. The first is to simulate +the brain electronically with supercomputers, which is the approach +being taken by the Europeans. The second is to map out the neural +pathways of living brains, as in BRAIN. (This task, in turn, can be further +subdivided, depending on how these neurons are analyzed—either +anatomically, neuron by neuron, or by function and activity.) And third, +one can decipher the genes that control the development of the brain, +which is an approach pioneered by billionaire Paul Allen of Microsoft." +"The first approach, simulating the brain using transistors and +computers, is forging ahead by reverse engineering the brains of animals +in a certain sequence: first a mouse, then a rat, rabbit, and a cat. The +Europeans are following the rough trail of evolution, starting with +simple brains and working upward. To a computer scientist, the solution +is raw computing power—the more, the better. And this means using +some of the largest computers on Earth to decipher the brains of mice +and men." +"Their first target is the brain of a mouse, which is one-thousandth the +size of a human brain, containing about one hundred million neurons. +The thinking process behind a mouse brain is being analyzed by the IBM +Blue Gene computer, located at the Lawrence Livermore National +Laboratory in California, where some of the biggest computers in the +world are located; they’re used to design hydrogen warheads for the +Pentagon. This colossal collection of transistors, chips, and wires +contains 147,456 processors with a staggering 150,000 gigabytes of +memory. (A typical PC may have one processor and a few gigabytes of + + memory.) + +Progress has been slow but steady. Instead of modeling the entire +brain, scientists try to duplicate just the connections between the cortex +and the thalamus, where much of brain activity is concentrated. (This +means that the sensory connections to the outside world are missing in +this simulation.)" +"In 2006, Dr. Dharmendra Modha of IBM partially simulated the mouse +brain in this way with 512 processors. In 2007, his group simulated the +rat brain with 2,048 processors. In 2009, the cat brain, with 1.6 billion +neurons and nine trillion connections, was simulated with 24,576 +processors. + +Today, using the full power of the Blue Gene computer, IBM scientists +have simulated 4.5 percent of the human brain’s neurons and synapses. +To begin a partial simulation of the human brain, one would need +880,000 processors, which might be possible around 2020. + +I had a chance to film the Blue Gene computer. To get to the +laboratory, I had to go through layers and layers of security, since it is +the nation’s premier weapons laboratory, but once you have cleared all +the checkpoints, you enter a huge, air-conditioned room housing Blue +Gene." +"The computer is truly a magnificent piece of hardware. It consists of +racks and racks of large black cabinets full of switches and blinking +lights, each about eight feet tall and roughly fifteen feet long. As I +walked among the cabinets that make up Blue Gene, I wondered what +kinds of operations it was performing. Most likely, it was modeling the +interior of a proton, calculating the decay of plutonium triggers, +simulating the collision of two black holes, and thinking of a mouse, all +at once. + +Then I was told that even this supercomputer is giving way to the next +generation, the Blue Gene/Q Sequoia, which will take computing to a +new level. In June 2012, it set the world’s record for the fastest +supercomputer. At peak speed, it can perform operations at 20.1 PFLOPS +(or 20.1 trillion floating point operations per second). It covers an area +of three thousand square feet, and gobbles up electrical energy at the +rate of 7.9 megawatts, enough power to light up a small city." +"But with all this massive computational firepower concentrated in one +computer, is it enough to rival the human brain? + +Unfortunately, no. + + These computer simulations try only to duplicate the interactions +between the cortex and the thalamus. Huge chunks of the brain are +therefore missing. Dr. Modha understands the enormity of his project. +His ambitious research has allowed him to estimate what it would take +to create a working model of the entire human brain, and not just a +portion or a pale version of it, complete with all parts of the neocortex +and connections to the senses. He envisions using not just a single Blue +Gene computer but thousands of them, which would fill up not just a +room but an entire city block. The energy consumption would be so +great that you would need a thousand-megawatt nuclear power plant to +generate all the electricity. And then, to cool off this monstrous +computer so it wouldn’t melt, you would need to divert a river and send +it through the computer circuits." +"It is remarkable that a gigantic, city-size computer is required to +simulate a piece of human tissue that weighs three pounds, fits inside +your skull, raises your body temperature by only a few degrees, uses +twenty watts of power, and needs only a few hamburgers to keep it +going. + +BUILDING A BRAIN + +But perhaps the most ambitious scientist who has joined this campaign is +Dr. Henry Markram of the Ecole Polytechnique Federate de Lausanne, in +Switzerland. He is the driving force behind the Human Brain Project, +which has received over a billion dollars of funding from the European +Commission. He has spent the last seventeen years of his life trying to + +decode the brain’s neural wiring. He, too, is using the Blue Gene +computer to reverse engineer the brain. At present, his Human Brain +Project is running up a bill of $140 million from the European Union, +and that represents only a fraction of the computer firepower he will +need in the coming decade." +"Dr. Markram believes that this is no longer a science project but an +engineering endeavor, requiring vast sums of money. He says, “To build +this—the supercomputers, the software, the research—we need around +one billion dollars. This is not expensive when one considers that the +global burden of brain disease will exceed twenty percent of the world +gross domestic project very soon.” To him, a billion dollars is nothing, +just a pittance compared to the hundreds of billions in bills stemming +from Alzheimer’s, Parkinson’s, and other related diseases when the baby +boomers retire. + +So to Dr. Markram, the solution is one of scale. Throw enough money + + at the project, and the human brain will emerge. Now that he has won +the coveted billion-dollar prize from the European Commission, his +dream may become a reality." +"He has a ready answer when asked what the average taxpayer will get +from this billion-dollar investment. There are three reasons, he says, for +embarking on this lonely but expensive quest. First, “It’s essential for us +to understand the human brain if we want to get along in society, and I +think that it is a key step in evolution. The second reason is, we cannot +keep doing animal experimentation forever.... It’s like a Noah’s Ark. It’s +like an archive. And the third reason is that there are two billion people +on this planet that are affected by mental disorder....” + +To him, it is a scandal that so little is known about mental diseases, +which cause so much suffering to millions of people. He says, “There’s +not a single neurological disease today in which anybody knows what is +malfunctioning in this circuit—which pathway, which synapse, which +neuron, which receptor. This is shocking.”" +"At first, it may sound impossible to complete this project, with so +many neurons and so many connections. It seems like a fool’s errand. +But these scientists think they have an ace in the hole. + +The human genome consists of roughly twenty-three thousand genes, +yet it can somehow create the brain, which consists of one hundred +billion neurons. It seems to be a mathematical impossibility to create the + +human brain from our genes, yet it happens every time an embryo is +conceived. How can so much information be crammed into something so +small? + +The answer, Dr. Markram believes, is that nature uses shortcuts. The +key to his approach is that certain modules of neurons are repeated over +and over again once Mother Nature finds a good template. If you look at +microscopic slices of the brain, at first you see nothing but a random +tangle of neurons. But upon closer examination, patterns of modules that +are repeated over and over appear." +"(Modules, in fact, are one reason why it is possible to assemble large +skyscrapers so rapidly. Once a single module is designed, it is possible to +repeat it endlessly on the assembly line. Then you can rapidly stack +them on top of one another to create the skyscraper. Once the +paperwork is all signed, an apartment building can be assembled using +modules in a few months.) + +The key to Dr. Markram’s Blue Brain project is the “neocortical +column,” a module that is repeated over and over in the brain. In + + humans, each column is about two millimeters tall, with a diameter of +half a millimeter, and contains sixty thousand neurons. (As a point of +comparison, rat neural modules contain only ten thousand neurons +each.) It took ten years, from 1995 to 2005, for Dr. Markram to map the +neurons in such a column and to figure out how it worked. Once that +was deciphered, he then went to IBM to create massive iterations of +these columns." +"He is the eternal optimist. In 2009, at a TED conference, he claimed he +could finish the project in ten years. (Most likely, this will be for a +stripped-down version of the human brain without any attachment to +the other lobes or to the senses.) But he has claimed, “If we build it +correctly, it should speak and have an intelligence and behave very +much as a human does.” + +Dr. Markram is a skilled defender of his work. He has an answer for +everything. When critics say that he is treading on forbidden territory, +he counters, “As scientists, we need to be not afraid of the truth. We +need to understand our brain. It’s natural that people would think that +the brain is sacred, that we shouldn’t tamper with it because it may be +where the secrets of the soul are. But I think, quite honestly, that if the +planet understood how the brain functions, we would resolve conflicts" +"everywhere. Because people would understand how trivial and how +deterministic and how controlled conflicts and reactions and +misunderstandings are.” + +When faced with the final criticism that he is “playing God,” he says, +“I think we’re far from playing God. God created the whole universe. +We’re just trying to build a little model.” + +IS IT REALLY A BRAIN? + +Although these scientists claim that their computer simulation of the +brain will begin to reach the capability of the human brain by around +2020, the main question is, How realistic is this simulation? Can the cat +simulation, for example, catch a mouse? Or play with a ball of yarn?" +"The answer is no. These computer simulations try to match the sheer +power of the neurons firing in the cat brain, but they cannot duplicate +the way in which the regions of the brain are hooked together. The IBM +simulation is only for the thalamocortical system (i.e., the channel that +connects the thalamus to the cortex). The system does not have a +physical body, and hence all the complex interactions between the brain +and the environment are missing. The brain has no parietal lobe, so it + + has no sensory or motor connections with the outside world. And even +within the thalamocortical system, the basic wiring does not respect the +thinking process of a cat. There are no feedback loops and memory +circuits for stalking prey or finding a mate. The computerized cat brain +is a blank slate, devoid of any memories or instinctual drives. In other +words, it cannot catch a mouse." +"So even if it is possible to simulate a human brain by around 2020, +you will not be able to have a simple conversation with it. Without a +parietal lobe, it would be like a blank slate without sensations, devoid of +any knowledge of itself, people, and the world around it. Without a +temporal lobe, it would not be able to talk. Without a limbic system, it +would not have any emotions. In fact, it would have less brain power +than a newborn infant. + +The challenge of hooking up the brain to the world of sensations, +emotions, language, and culture is just beginning. + +THE SLICE-AND-DICE APPROACH + +The next approach, favored by the Obama administration, is to map the +neurons of the brain directly. Instead of using transistors, this approach +analyzes the actual neural pathways of the brain. There are several +components to it." +"One way to proceed is to physically identify each and every neuron +and synapse of the brain. (The neurons are usually destroyed by this +process.) This is called the anatomical approach. Another path is to +decipher the ways in which electrical signals flow across neurons when +the brain is performing certain functions. (The latter approach, which +stresses identifying the pathways of the living brain, is the one that +seems to be favored by the Obama administration.)" +"The anatomical approach is to take apart the cells of an animal brain, +neuron by neuron, using the “slice-and-dice” method. In this way, the +full complexity of the environment, the body, and memories are already +encoded in the model. Instead of approximating a human brain by +assembling a huge number of transistors, these scientists want to identify +each neuron of the brain. After that, perhaps each neuron can be +simulated by a collection of transistors so that you’d have an exact +replica of the human brain, complete with memory, personality, and +connection to the senses. Once someone’s brain is fully reversed +engineered in this way, you should be able to have an informative +conversation with that person, complete with memories and a +personality." +"No new physics is required to finish the project. Using a device similar +to a meat sheer in a delicatessen, Dr. Gerry Rubin of the Howard Hughes +Medical Institute has been slicing the brain of a fruit fly. This is not an +easy task, since the fruit fly brain is only three hundred micrometers +across, a tiny speck compared to the human brain. The fruit fly brain +contains about 150,000 neurons. Each slice, which is only fifty-billionths +of a meter across, is meticulously photographed with an electron +microscope, and the images are fed into a computer. Then a computer +program tries to reconstruct the wiring, neuron by neuron. At the +present rate, Dr. Rubin will be able to identify every neuron in the fruit +fly brain in twenty years. + +The snail-like pace is due, in part, to current photographic technology," +"The snail-like pace is due, in part, to current photographic technology, + +since a standard scanning microscope operates at about ten million +pixels per second. (That is about a third of the resolution achieved by a +standard TV screen per second.) The goal is to have an imaging machine +that can process ten billion pixels per second, which would be a world +record. + +The problem of how to store the data pouring in from the microscope +is also staggering. Once his project gets up to speed, Rubin expects to +scan about a million gigabytes of data per day for just a single fruit fly, +so he envisions filling up huge warehouses full of hard drives. On top of +that, since every fruit fly brain is slightly different, he has to scan +hundreds of fruit fly brains in order to get an accurate approximation of +one." +"Based on working with the fruit fly brain, how long will it take to +eventually slice up the human brain? “In a hundred years, I’d like to +know how human consciousness works. The ten- or twenty-year goal is +to understand the fruit fly brain,” he says. + +This method can be speeded up with several technical advances. One +possibility is to use an automated device, so that the tedious process of +slicing the brain and analyzing each slide is done by machine. This could +rapidly reduce the time for the project. Automation, for example, vastly +reduced the cost of the Human Genome Project (although it was +budgeted at $3 billion, it was accomplished ahead of time and under +budget, which is unheard of in Washington). Another method is to use a +large variety of dyes that will tag different neurons and pathways, +making them easier to see. An alternative approach would be to create +an automated super microscope that can scan neurons one by one with +unparalleled detail." +"Given that a complete mapping of the brain and all its senses will take +up to a hundred years, these scientists feel somewhat like the medieval + + architects who designed the cathedrals of Europe, knowing that their +grandchildren would finally complete the project. + +In addition to constructing an anatomical map of the brain, neuron by +neuron, there is a parallel effort called the “Human Connectome +Project,” which uses brain scans to reconstruct the pathways connecting +various regions of the brain. + +THE HUMAN CONNECTOME PROJECT" +"THE HUMAN CONNECTOME PROJECT + +In 2010, the National Institutes of Health announced that it was +allocating $30 million, spread out over five years, to a consortium of +universities (including Washington University in St. Louis and the +University of Minnesota), and a $8.5 million grant over three years to a +consortium led by Harvard University, Massachusetts General Hospital, +and UCLA. With this level of short-term funding, of course, researchers +cannot fully sequence the entire brain, but the funding was meant to +jump-start the effort." +"Most likely, this effort will be folded into the BRAIN project, which +will vastly accelerate this work. The goal is to produce a neuronal map +of the human brain’s pathways that will elucidate brain disorders such as +autism and schizophrenia. One of the leaders of the Connectome Project, +Dr. Sebastian Seung, says, “Researchers have conjectured that the +neurons themselves are healthy, but maybe they are just wired together +in an abnormal way. But we’ve never had the technology to test that +hypothesis until now.” If these diseases are actually caused by the +miswiring of the brain, then the Human Connectome Project may give us +an invaluable clue as to how to treat these conditions." +"When considering the ultimate goal of imaging the entire human +brain, sometimes Dr. Seung despairs of ever finishing this project. He +says, “In the seventeenth century, the mathematician and philosopher +Blaise Pascal wrote of his dread of the infinite, his feeling of +insignificance at contemplating the vast reaches of outer space. And as a +scientist, I’m not supposed to talk about my feelings.... I feel curiosity, +and I feel wonder, but at times I have also felt despair.” But he and +others like him persist, even if their project will take multiple +generations to finish. They have reason to hope, since one day +automated microscopes will tirelessly take the photographs and +artificially intelligent machines will analyze them twenty-four hours a +day. But right now, just imaging the human brain with ordinary electron +microscopes would consume about one zettabyte of data, which is +equivalent to all the data compiled in the world today on the web." +"Dr. Seung even invites the public to participate in this great project by + + visiting a website called EyeWire. There, the average “citizen scientist” +can view a mass of neural pathways and is asked to color them in + +(staying within their boundaries). It’s like a virtual coloring book, except +images are of the actual neurons in the retina of an eye, taken by an +electron microscope. + +THE ALLEN BRAIN ATLAS + +Finally, there is a third way to map the brain. Instead of analyzing the +brain by using computer simulations or by identifying all the neural +pathways, yet another approach was taken with a generous grant of +$100 million from Microsoft billionaire Paul Allen. The goal was to +construct a map or atlas of the mouse brain, with the emphasis on +identifying the genes responsible for creating the brain." +"It is hoped that this understanding of how genes are expressed in the +brain will help in understanding autism, Parkinson’s, Alzheimer’s, and +other disabilities. Since a large number of mouse genes are found in +humans, it’s possible that findings here will give us insight into the +human brain. + +With this sudden infusion of funds, the project was completed in 2006, +and its results are freely available on the web. A follow-up project, the +Allen Human Brain Atlas, was announced soon afterward, with the hope +of creating an anatomically and genetically complete 3-D map of the +human brain. In 2011, the Allen Institute announced that it had mapped +the biochemistry of two human brains, finding one thousand anatomical +sites with one hundred million data points detailing how genes are +expressed in the underlying biochemistry. The study confirmed that 82 +percent of our genes are expressed in the brain." +"“Until now, a definitive map of the human brain, at this level of detail, +simply hasn’t existed,” says Dr. Allen Jones of the Allen Institute. “The +Allen Human Brain Atlas provides never-before-seen views into our most +complex and most important organ,” he adds. + +OBJECTIONS TO REVERSE ENGINEERING + +Scientists who have dedicated their lives to reverse engineering the brain +realize that decades of hard work lie ahead of them. But they are also +convinced of the practical implications of their work. They feel that even + + partial results will help decode the mystery of mental diseases that have +afflicted humans throughout our history." +"The cynics, however, may claim that, after this arduous task is +finished, we will have a mountain of data with no understanding of how +it all fits together. For example, imagine a Neanderthal who one day +comes across the complete blueprint for an IBM Blue Gene computer. All +the details are there in the blueprint, down to the very last transistor. +The blueprint is huge, taking up thousands of square feet of paper. The +Neanderthal may be dimly aware that this blueprint is the secret of a +super-powerful machine, but the sheer mass of technical data means +nothing to him. + +Similarly, the fear is that, after spending billions deciphering the +location of every neuron of the brain, we won’t be able to understand +what it all means. It may take many more decades of hard work to see +how the whole thing functions." +"For example, the Human Genome Project was a smashing success in +sequencing all the genes that make up the human genome, but it was a +huge disappointment for those who expected immediate cures for +genetic diseases. The Human Genome Project was like a gigantic +dictionary, with twenty-three thousand entries but no definitions. Page +after page of this dictionary is blank, yet the spelling of each gene is +perfect. The project was a breakthrough, but at the same time it’s just +the first step in a long journey to figure out what these genes do and +how they interact. + +Similarly, just having a complete map of every single neural +connection in the brain does not guarantee that we will know what these +neurons are doing and how they react. Reverse engineering is the easy +part; after that, the hard part begins—making sense of all this data. + +THE FUTURE" +"THE FUTURE + +But assume for now that the moment has finally arrived. With much +fanfare, scientists solemnly announce that they have successfully reverse +engineered the entire human brain. + +Then what? + +One immediate application is to find the origins of certain mental + + diseases. It’s thought that many mental diseases are not caused by the +massive destruction of neurons, but by a simple misconnection. Think of +genetic diseases that are caused by a single mutation, like Huntington’s +disease, Tay-Sachs, or cystic fibrosis. Out of three billion base pairs, a +single misspelling (or repetition) can cause uncontrollable flailing of +your limbs and convulsions, as in Huntington’s disease. Even if the +genome is 99.9999999 percent accurate, a tiny flaw might invalidate the +entire sequence. That is why gene therapy has targeted these single +mutations as possible genetic diseases that can be fixed." +"Likewise, once the brain is reverse engineered, it might be possible to +run simulations of the brain, deliberately disrupting a few connections to +see if you can induce certain illnesses. Only a handful of neurons may be +responsible for major disruptions of our cognition. Locating this tiny +collection of misfiring neurons may be one of the jobs of the reverse- +engineered brain." +"One example might be Capgras delusion, in which you see someone +you recognize as your mother, but you believe that person to be an +impostor. According to Dr. V. S. Ramachandran, this rare disease might +be due to a misconnection between two parts of the brain. The fusiform +gyrus in the temporal lobe is responsible for recognizing the face of your +mother, but the amygdala is responsible for your emotional response in +seeing your mother. When the connection between these two centers is +disrupted, an individual can recognize his mother’s face perfectly well, +but, since there is no emotional response, he is also convinced that she is +an impostor." +"Another use for the reverse-engineered brain is to pinpoint precisely +which cluster of neurons is misfiring. Deep brain stimulation, as we’ve +seen, involves using tiny probes to dampen the activity of a tiny portion +of the brain, such as Broadmann’s area 25, in the case of certain severe +forms of depression. Using the reverse-engineered map, it might be +possible to find precisely where the neurons are misfiring, which may +involve only a handful of neurons. + +A reversed-engineered brain would also be of great help to AI. Vision +and face recognition are done effortlessly by the brain, but they still +elude our most advanced computers. For example, computers can +recognize with 95 percent or greater accuracy human faces that look +straight ahead and are part of a small data bank, but if you show the" +"computer the same face from different angles or a face that’s not in the +database, the computer will most likely fail. Within .1 seconds, we can +recognize familiar faces from different angles; it’s so easy for our brains +that we are not even aware we are doing it. Reverse engineering the +brain may reveal the mystery of how this is done. + + More complicated would be diseases that involve multiple failures of +the brain, such as schizophrenia. This disorder involves several genes, +plus interactions with the environment, which in turn cause unusual +activity in several areas of the brain. But even there, a reverse- +engineered brain would be able to tell precisely how certain symptoms +(such as hallucinations) are formed, and this might pave the way for a +possible cure." +"A reverse-engineered brain would also solve such basic but unresolved +questions as how long-term memories are stored. It is known that certain +parts of the brain, such as the hippocampus and amygdala, store +memories, but how the memory is dispersed through various cortices +and then reassembled to create a memory is still unclear. + +Once the reverse-engineered brain is fully functional, then it will be +time to turn on all its circuits to see if it can respond like a human (i.e., +to see if it can pass the Turing test). Since long-term memory is already +encoded in the neurons of the reverse-engineered brain, it should be +obvious very quickly whether the brain can respond in a way +indistinguishable from a human. + +Finally, there is one impact of reverse engineering the brain that is +rarely discussed but is on many people’s minds: immortality. If +consciousness can be transferred into a computer, does that mean we +don’t have to die?" +"Speculation is never a waste of time. It clears away the +deadwood in the thickets of deduction. + +—ELIZABETH PETERS + +We are a scientific civilization.... That means a civilization in +which knowledge and its integrity are crucial. Science is only a +Latin word for knowledge.... Knowledge is our destiny. + +—JACOB BRONOWSKI + +12 THE FUTURE MIND BEYOND MATTER + +Can consciousness exist by itself, free from the constraints of the +physical body? Can we leave our mortal body and, like spirits, wander +around this playground called the universe? This was explored on Star" +"Trek, when Captain Kirk of the starship Enterprise encounters a +superhuman race, almost a million years more advanced than the +Federation of Planets. They are so advanced that they have long since +abandoned their frail, mortal bodies, and now inhabit pulsating globes of +pure energy. It has been millennia since they could feel intoxicating +sensations, such as breathing fresh air, touching another’s hand, or +feeling physical love. Their leader, Sargon, welcomes the Enterprise to +their planet. Captain Kirk accepts the invitation, acutely aware that this +civilization could instantly vaporize the Enterprise if it wanted to. + +But unknown to the crew, these super beings have a fatal weakness. +For all their advanced technology, they have been severed for hundreds +of thousands of years from their physical bodies. As such, they yearn to +feel the rush of physical sensations and long to become human again." +"One of these super beings, in fact, is evil and determined to gain +possession of the physical bodies of the crew. He wants to live like a +human, even if it means destroying the mind of the body’s owner. Soon a +battle breaks out on the deck of the Enterprise, as the evil entity seizes +control of Spock’s body and the crew fights back. + +Scientists have asked themselves, Is there a law of physics preventing +the mind from existing without the body? In particular, if the conscious +human mind is a device that constantly creates models of the world and +simulates them into the future, is it possible to create a machine that can +simulate this entire process? + +Previously, we mentioned the possibility of having our bodies placed +in pods, as in the movie Surrogates, while we mentally control a robot. +The problem here is that our natural body will still gradually wither +away, even if our robot surrogate keeps on going. Serious scientists are" +"contemplating whether we can actually transfer our minds into a robot +so we can become truly immortal. And who wouldn’t want a chance at +eternal life? As Woody Allen once said, “I don’t want to live forever +through my works. I want to live forever by not dying.” + +Actually, millions of people already claim that it is possible for the +mind to leave the body. In fact, many insist that they have done it +themselves. + +OUT-OF-BODY EXPERIENCES + +The idea of minds without bodies is perhaps the oldest of our +superstitions, embedded deep within our myths, folklore, dreams, and + + perhaps even our genes. Every society, it seems, has some tale of ghosts +and demons who can enter and leave the body at will." +"Sadly, many innocents were persecuted to exorcize the demons that +were supposedly possessing their bodies. They probably suffered from +mental illness, such as schizophrenia, in which victims are often haunted +by voices generated by their own minds. Historians believe that one of +the Salem witches who was hung in 1692 for being possessed probably +had a rare genetic condition, called Huntington’s disease, that causes +uncontrolled flailing of the limbs. + +Today some people claim that they have entered a trancelike state in +which their consciousness has left their body and is free to roam +throughout space, even able to look back at their mortal body. In a poll +of thirteen thousand Europeans, 5.8 percent claimed they had had an +out-of-body experience. Interviews with people in the United States +show similar numbers." +"Nobel laureate Richard Feynman, always curious about new +phenomena, once placed himself in a sensory deprivation tank and tried +to leave his physical body. He was successful. He would later write that +he felt that he had left his body, drifted into space, and saw his +motionless body when he looked back. However, Feynman later +concluded that this was probably just his imagination, caused by sensory +deprivation. + +Neurologists who have studied this phenomenon have a more prosaic +explanation. Dr. Olaf Blanke and his colleagues in Switzerland may have" +"located the precise place in the brain that generates out-of-body +experiences. One of his patients was a forty-three-year-old woman who +suffered from debilitating seizures that came from her right temporal +lobe. A grid of about one hundred electrodes was placed over her brain +in order to locate the region responsible for her seizures. When the +electrodes stimulated the area between the parietal and temporal lobes, +she immediately had the sensation of leaving her body. “I see myself +lying in bed, from above, but I only see my legs and lower trunk!” she +exclaimed. She felt she was floating six feet above her body." +"When the electrodes were turned off, however, the out-of-body +sensation disappeared immediately. In fact, Dr. Blanke found that he +could turn the out-of-body sensation on and off, like a light switch, by +repeatedly stimulating this area of the brain. As we saw in Chapter 9, +temporal lobe epileptic lesions can induce the feeling that there are evil +spirits behind every misfortune, so the concept of spirits leaving the +body is perhaps part of our neural makeup. (This may also explain the +presence of supernatural beings. When Dr. Blanke analyzed a twenty- + + two-year-old woman who was suffering from intractable seizures, he +found that, by stimulating the temporoparietal area of the brain, he +could induce the sensation that there was a shadowy presence behind +her. She could describe this person, who even grabbed her arms, in +detail. His position would change with each appearance, but he would +always appear behind her.)" +"Human consciousness, I believe, is the process of continually forming +a model of the world, in order to simulate the future and carry out a +goal. In particular, the brain is receiving sensations from the eyes and +inner ear to create a model of where we are in space. However, when +the signals from our eyes and ears are in contradiction, we become +confused about our location. We often get nauseous and throw up. For +example, many people develop sea sickness when they are on a rocking +boat because their eyes, looking at the cabin walls, tell them that they +are stationary, but their inner ear tells them that they are swaying. The +mismatch between these signals causes them to become nauseous. The +remedy is to look out at the horizon so that the visual image matches the +signals from the inner ear. (This same sense of nausea can be induced +even if you are stationary. If you look at a spinning garbage can with +bright vertical stripes painted on it, the stripes seem to move" +"horizontally across your eyes, giving you the sensation that you are +moving. But your inner ear says you are stationary. The resulting +mismatch causes you to throw up after a few minutes, even if you are +sitting in a chair.) + +The messages from the eyes and inner ear can also be disrupted +electrically, at the boundary of the temporal and parietal lobes, and this +is the origin of out-of-body experiences. When this sensitive area is +touched, the brain gets confused about where it is located in space. +(Notably, temporary loss of blood or oxygen or excess carbon dioxide in +the blood can also cause a disruption in the temporoparietal region and +induce out-of-body experiences, which may explain the prevalence of +these sensations during accidents, emergencies, heart attacks, etc.) + +NEAR-DEATH EXPERIENCES" +"NEAR-DEATH EXPERIENCES + +But perhaps the most dramatic category of out-of-body experiences are +the near-death stories of individuals who have been declared dead but +then mysteriously regained consciousness. In fact, 6 to 12 percent of +survivors of cardiac arrest report having near-death experiences. It’s as +though they have cheated death itself. When interviewed, they have +dramatic tales of the same experience: they left their body and drifted +toward a bright light at the end of a long tunnel." +"The media have seized upon this, with numerous best sellers and TV +documentaries devoted to these theatrical stories. Many bizarre theories +have been proposed to explain near-death experiences. In a poll of two +thousand people, fully 42 percent believed that near-death experiences +were proof of contact with the spiritual world that lies beyond death. +(Some believe that the body releases endorphins—natural narcotics— +before death. This may explain the euphoria that people feel, but not the +tunnel and the bright lights.) Carl Sagan even speculated that near-death +experiences were a reliving of the trauma of birth. The fact that these +individuals recount very similar experiences doesn’t necessarily +corroborate their glimpses into the afterlife; in fact, it seems to indicate +that there is some deep neurological event happening. + +Neurologists have looked into this phenomenon seriously and suspect +that the key may be the decrease of blood flow to the brain that often" +"accompanies near-death cases, and which also occurs in fainting. Dr. +Thomas Lempert, a neurologist at the Castle Park Clinic in Berlin, +conducted a series of experiments on forty-two healthy individuals, +causing them to faint under controlled laboratory conditions. Sixty +percent of them had visual hallucinations (e.g., bright lights and colored +patches). Forty-seven percent of them felt that they were entering +another world. Twenty percent claimed to have encountered a +supernatural being. Seventeen percent saw a bright light. Eight percent +saw a tunnel. So fainting can mimic all the sensations people have in +near-death experiences. But precisely how does this happen?" +"The mystery of how fainting can simulate near-death experiences may +be solved by analyzing the experiences of military pilots. The U.S. Air +Force, for example, contacted neurophysiologist Dr. Edward Lambert to +analyze military pilots who blacked out when experiencing high g forces +(i.e., when executing a tight turn in a jet or pulling out of a dive). Dr. +Lampert placed pilots in an ultracentrifuge at the Mayo Clinic in +Rochester, Minnesota, which spun them around in a circle until they +experienced high g forces. As blood drained from their brain, they would +become unconscious after fifteen seconds of experiencing several g’s of +acceleration." +"He found that after only five seconds, the blood flow to the pilots’ eyes +diminished, so that their peripheral vision dimmed, creating the image +of a long tunnel. This could explain the tunnel that is often seen by +people having a near-death experience. If the periphery of your vision +blacks out, all you see is the narrow tunnel in front of you. But because +Dr. Lampert could carefully adjust the velocity of the centrifuge by +turning a dial, he found he could keep the pilots in this state indefinitely, +allowing him to prove that this tunnel vision is caused by loss of blood +flow to the periphery of the eye. + + CAN CONSCIOUSNESS LEAVE YOUR BODY? + +Some scientists who have investigated near-death and out-of-body +experiences are convinced that they are by-products of the brain itself +when it is placed under stressful conditions and its wiring gets confused. +However, there are other scientists who believe that one day, when our" +"technology is sufficiently advanced decades from now, one’s +consciousness may truly be able to leave the body. Several controversial +methods have been suggested." +"One method has been pioneered by futurist and inventor Dr. Ray +Kurzweil, who believes that consciousness may one day be uploaded into +a supercomputer. We once spoke at a conference together, and he told +me his fascination with computers and artificial intelligence began when +he was five years old and his parents bought him all sorts of mechanical +devices and toys. He loved to tinker with these devices, and even as a +child he knew he was destined to become an inventor. At MIT, he +received his doctorate under Dr. Marvin Minsky, one of the founders of +AI. Afterward, he cut his teeth applying pattern-recognition technology +to musical instruments and text-to-sound machines. He was able to +translate AI research in these areas into a string of companies. (He sold +his first company when he was only twenty.) His optical reader, which +could recognize text and convert it into sound, was heralded as an aid +for the blind, and was even mentioned by Walter Cronkite on the +evening news." +"In order to be a successful inventor, he said to me, you always have to +be ahead of the curve, to anticipate change, not react to it. Indeed, Dr. +Kurzweil loves to make predictions, and many of them have mirrored +the remarkable exponential growth of digital technology. He made the +following predictions: + +• By 2019, a $1,000 PC will have the computing power of the human +brain—twenty million billion calculations per second. (This number +is obtained by taking the one hundred billion neurons of the brain, +multiplying one thousand connections per neuron, and two hundred +calculations per second per connection.) + +• By 2029, a $1,000 PC will be a thousand times more powerful than +the human brain; the human brain itself will be successfully +reversed engineered. + +• By 2055, $1,000 of computing power will equal the processing + + power of all the humans on the planet. (He adds modestly, “I may +be off by a year or two.”)" +"power of all the humans on the planet. (He adds modestly, “I may +be off by a year or two.”) + +In particular, the year 2045 looms as an important one for Dr. +Kurzweil, since that is when he believes the “singularity” will take hold. +By then, he claims, machines will have surpassed humans in intelligence +and in fact will have created next-generation robots even smarter than +themselves. Since this process can continue indefinitely, it means, +according to Dr. Kurzweil, a never-ending acceleration of the power of +machines. In this scenario, we should either merge with our creations or +step out of their way. (Although these dates are in the far future, he told +me that he wants to live long enough to see the day when humans +finally become immortal; that is, he wants to live long enough to live +forever.)" +"As we know from Moore’s law, at a certain point computer power can +no longer advance by creating smaller and smaller transistors. In +Kurzweil’s opinion, the only way to expand computing power further +would be to increase overall size, which would leave robots scavenging +for more computer power by devouring the minerals of the Earth. Once +the planet has become a gigantic computer, robots may be forced to go +into outer space, searching for more sources of computer power. +Eventually, they may consume the power of entire stars. + +I once asked him if this cosmic growth of computers could alter the +cosmos itself. Yes, he replied. He told me that he sometimes looks at the +night sky, wondering if on some distant planet intelligent beings have +already attained the singularity. If so, then perhaps they should leave +some mark on the stars themselves that might be visible to the naked +eye." +"One limitation he told me, is the speed of light. Unless these machines +can break the light barrier, this exponential rise in power may hit a +ceiling. When that happens, says Kurzweil, perhaps they will alter the +laws of physics themselves. + +Anyone who makes predictions with such precision and scope +naturally invites criticism like a lightning rod, but it doesn’t seem to faze +him. People can quibble about this or that prediction, since Kurzweil has +missed some of his deadlines, but he is mainly concerned about the +thrust of his ideas, which predict the exponential growth of technology. +To be fair, most people working in the field of AI whom I have +interviewed agree that some form of a singularity will happen, but they +disagree sharply on when it might occur and how it will unfold. For" +"example, Bill Gates, cofounder of Microsoft, believes that no one alive +today will live to see the day when computers are smart enough to pass +for a human. Kevin Kelly, an editor for Wired magazine, has said, +“People who predict a very utopian future always predict that it is going +to happen before they die.” + +Indeed, one of Kurzweil’s many goals is to bring his father back to life. +Or rather, he wants to create a realistic simulation. There are several +possibilities, but all are still highly speculative. + +Kurzweil proposes that perhaps DNA can be extracted from his father +(from his grave site, relatives, or organic materials he left behind). +Contained within roughly twenty-three thousand genes would be a +complete blueprint to re-create the body of that individual. Then a clone +could be grown from the DNA." +"This is certainly a possibility. I once asked Dr. Robert Lanza of the +company Advanced Cell Technology how he was able to bring a long- +dead creature “back to life,” making history in the process. He told me +that the San Diego Zoo asked him to create a clone of a banteng, an +oxlike creature that had died out about twenty-five years earlier. The +hard part was extracting a usable cell for the purpose of cloning. +However, he was successful, and then he FedExed the cell to a farm, +where it was implanted into a female cow, which then gave birth to this +animal. Although no primate has ever been cloned, let alone a human, +Lanza feels it’s a technical problem, and that it’s only a matter of time +before someone clones a human." +"This would be the easy part, though. The clone would be genetically +equivalent to the original, but without its memories. Artificial memories +might be uploaded to the brain using the pioneering methods described +in Chapter 5, such as inserting probes into the hippocampus or creating +an artificial hippocampus, but Kurzweil’s father has long passed, so it’s +impossible to make the recording in the first place. The best one can do +is to assemble piecemeal all historical data about that person, such as by +interviewing others who possess relevant memories, or accessing their +credit card transactions, etc., and then inputting them into the program. + +A more practical way of inserting a person’s personality and memory +would be to create a large data file containing all known information +about a person’s habits and life. For example, today it is possible to store +all your e-mail, credit card transactions, records, schedules, electronic" +"diaries, and life history onto a single file, which can create a remarkably +accurate picture of who you are. This file would represent your entire +“digital signature,” representing everything that is known about you. It +would be remarkably accurate and intimate, detailing what wines you +like, how you spend vacations, what kind of soap you use, your favorite + + singer, and so on." +"Also, with a questionnaire, it would be possible to create a rough +approximation of Kurzweil’s father’s personality. His friends, relatives, +and associates would fill out a questionnaire containing scores of +questions about his personality, such as whether he was shy, curious, +honest, hardworking, etc. Then they would assign a number to each trait +(e.g., a “10” would mean that you are very honest). This would create a +string of hundreds of numbers, each one ranking a specific personality +trait. Once this vast set of numbers was compiled, a computer program +would take these data and approximate how he would behave in +hypothetical situations. Let’s say that you are giving a speech and are +confronted with an especially obnoxious heckler. The computer program +would then scan the numbers and then predict one of several possible +outcomes (e.g., ignore the heckler, heckle back, or get into a brawl with +the heckler). In other words, his basic personality would be reduced to a" +"the heckler). In other words, his basic personality would be reduced to a +long string of numbers, each from 1 to 10, which can be used by a +computer to predict how he would react to new situations." +"The result would be a vast computer program that would respond to +new situations roughly the way the original person would have, using +the same verbal expressions and having the same quirks, all tempered +with the memories of that person. + +Another possibility would be to forgo the whole cloning process and +simply create a robot resembling the original person. It would then be +straightforward to insert this program into a mechanical device that +looks like you, talks with the same accent and mannerisms, and moves +its arms and limbs the same way that you do. Adding your favorite +expressions (e.g., “you know ...”) would also be easy. + +Of course, today it would be easy to detect that this robot is a fake. +However, in the coming decades, it may be possible to get closer and +closer to the original, so it might be good enough to fool some people. + +But this raises a philosophical question. Is this “person” really the +same as the original? The original is still dead, so the clone or robot is," +"strictly speaking, still an impostor. A tape recorder, for example, might +reproduce a conversation we have with perfect fidelity, but that tape +recorder is certainly not the original. Can a clone or robot that behaves +just like the original be a valid substitute? + +IMMORTALITY + + These methods have been criticized because this process does not +realistically input your true personality and memories. A more faithful +way of putting a mind into a machine is via the Connectome Project, +which we discussed in the last chapter and which seeks to duplicate, +neuron for neuron, all the cellular pathways of your brain. All your +memories and personality quirks are already embedded in the +connectome." +"The Connectome Project’s Dr. Sebastian Seung notes that some people +pay $100,000 or more to have their brains frozen in liquid nitrogen. +Certain animals, like fish and frogs, can be frozen solid in a block of ice +in winter yet be perfectly healthy after thawing out in spring. This is +because they use glucose as an antifreeze to alter the freezing point of +water in their blood. Thus their blood remains liquid, even though they +are encased in solid ice. This high concentration of glucose in the human +body, however, would probably be fatal, so freezing the human brain in +liquid nitrogen is a dubious pursuit because expanding ice crystals would +rupture the cell wall from the inside (and also, as brain cells die, calcium +ions rush in, causing the brain cells to expand until they finally rupture). +In either case, brain cells would most likely not survive the freezing +process." +"Rather than freezing the body and having the cells rupture, a more +reliable process to attain immortality might be to have your connectome +completed. In this scenario, your doctor would have all your neural +connections on a hard drive. Basically, your soul would now be on a +disk, reduced to information. Then at a future point, someone would be +able to resurrect your connectome and, in principle, use either a clone or +a tangle of transistors to bring you back to life. + +The Connectome Project, as we mentioned, is still far from being able +to record a human’s neural connections. But as Dr. Seung says, “Should + +we ridicule the modern seekers of immortality, calling them fools? Or +will they someday chuckle over our graves?” + +MENTAL ILLNESS AND IMMORTALITY" +"MENTAL ILLNESS AND IMMORTALITY + +Immortality may have its drawbacks, however. The electronic brains +being built so far contain only the connections between the cortex and +the thalamus. The reverse-engineered brain, lacking a body, might begin +to suffer from sensory isolation and even manifest signs of mental illness, +as prisoners do when they are placed into solitary confinement. Perhaps +the price of creating an immortal, reverse-engineered brain is madness." +"Subjects who are placed in isolation chambers, where they are +deprived of any contact with the outside world, eventually hallucinate. +In 2008, BBC-TV aired a science program titled Total Isolation, in which +they followed six volunteers as they were placed inside a nuclear bunker, +alone and in complete darkness. After just two days, three of the +volunteers began to see and hear things—snakes, cars, zebras, and +oysters. After they were released, doctors found that all of them suffered +from mental deterioration. One subject’s memory suffered a 36 percent +drop. One can imagine that, after a few weeks or months of this, most of +them might go insane." +"To maintain the sanity of a reverse-engineered brain, it might be +essential to connect it to sensors that receive signals from the +environment so it would be able to see and feel sensations from the +outside world. But then another problem arises: it might feel that it is a +grotesque freak, an unwieldy scientific guinea pig living at the mercy of +a science experiment. Because this brain has the same memory and +personality as the original human, it would crave human contact. And +yet, lurking inside the memory of some supercomputer, with a macabre +jungle of electrodes dangling outside, the reverse-engineered brain +would be repulsive to any human. Bonding with it would be impossible. +Its friends would turn away. + +THE CAVEMAN PRINCIPLE + +At this point, what I call the Caveman Principle starts to kick in. Why do + +so many reasonable predictions fail? And why would someone not want +to live forever inside a computer?" +"The Caveman Principle is this: given a choice between high-tech or +high-touch, we opt for high-touch every time. For example, if we are +given a choice between tickets to see our favorite musician live or a CD +of the same musician in concert, which would we choose? Or if we are +given a choice between tickets to visit the Taj Mahal or just seeing a +beautiful picture of it, which would we prefer? More than likely the live +concert and the airplane tickets. + +This is because we have inherited the consciousness of our apelike +ancestors. Some of our basic personality has probably not changed much +in the last one hundred thousand years, since the first modern humans +emerged in Africa. A large portion of our consciousness is devoted to +looking good and trying to impress members of the opposite sex and our +peers. This is hardwired into our brains. + + More likely, given our basic, apelike consciousness, we will merge +with computers only if this enhances but does not totally replace our +present-day body." +"The Caveman Principle probably explains why some reasonable +predictions about the future never materialized, such as “the paperless +office.” Computers were supposed to banish paper from the office; +ironically, computers have actually created even more paper. This is +because we are descended from hunters who need “proof of the kill” +(i.e., we trust concrete evidence, not ephemeral electrons dancing on a +computer screen that vanish when you turn it off). Likewise, the +“peopleless city,” where people would use virtual reality to go to +meetings instead of commuting, never materialized. Commuting to cities +is worse than ever. Why? Because we are social animals who like to +bond with others. Videoconferencing, although useful, cannot pick up +the full spectrum of subtle information offered via body language. A +boss, for example, may want to ferret out problems in his staff and +therefore wants to see them squirm and sweat under interrogation. You +can do this only in person. + +CAVEMEN AND NEUROSCIENCE" +"CAVEMEN AND NEUROSCIENCE + +When I was a child, I read Isaac Asimov’s Foundation Trilogy and was +deeply influenced by it. First, it forced me to ask a simple question: +What will technology look like fifty thousand years in the future, when +we have a galactic empire? I also couldn’t help wondering throughout +the novel, Why do humans look and act the same as they do now? I +thought that surely thousands of years into the future humans should +have cyborg bodies with superhuman abilities. They should have given +up their puny human forms millennia ago." +"I came up with two answers. First, Asimov wanted to appeal to a +young audience willing to buy his book, so he had to create characters +that those people could identify with, including all their faults. Second, +perhaps people in the future will have the option to have superpowered +bodies but prefer to look normal most of the time. This would be +because their minds have not changed since humans first emerged from +the forest, and so acceptance from their peers and the opposite sex still +determines what they look like and what they want out of life. + +So now let us apply the Caveman Principle to the neuroscience of the +future. At the minimum, it means that any modification of the basic +human form would have to be nearly invisible on the outside. We don’t +want to resemble a refugee from a science-fiction movie, with electrodes +dangling from our head. Brain implants that might insert memories or +increase our intelligence will be adopted only if nanotechnology can" +"make microscopic sensors and probes that are invisible to the naked eye. +In the future, it might be possible to make nanofibers, perhaps made of +carbon nanotubes one molecule thick, so thin that they would be able to +make contact with neurons with surgical precision and yet leave our +appearance unaltered, with our mental capabilities enhanced. + +Meanwhile, if we need to be connected to a supercomputer to upload +information, we won’t want to be tied to a cable jacked into our spinal +cord, as in The Matrix. The connection will have to be wireless so we can +access vast amounts of computer power simply by mentally locating the +nearest server. + +Today we have cochlear implants and artificial retinas that can give +the gift of sound and sight to patients, but in the future our senses will +be enhanced using nanotechnology while we preserve our basic human +form. For instance, we might have the option of enhancing our muscles, +via genetic modification or exoskeletons. There could be a human body" +"shop from which we could order new spare parts as the old ones wear +out, but these and other physical enhancements of the body would have +to avoid abandoning the human form. + +Another way to use this technology in accordance with the Caveman +Principle is to use it as an option, rather than a permanent way of life. +One might want the option of plugging into this technology and then +unplugging soon afterward. Scientists may want to boost their +intelligence to solve a particularly tricky problem. But afterward, they +will be able to take off their helmets or implants and go about their +business. In this way, we are not caught looking like a space cadet to our +friends. The point is that no one would force you to do any of this. We +would want the option of enjoying the benefits of this technology +without the downside of looking silly." +"So in the centuries to come, it is likely our bodies will look very +similar to the ones we possess today, except that they will be perfect and +have enhanced powers. It is a relic of our apelike past that our +consciousness is dominated by ancient desires and wishes. + +But what about immortality? As we have seen, a reverse-engineered +brain, with all the personality quirks of the original person, would +eventually go mad if placed inside a computer. Furthermore, connecting +this brain to external sensors so it could feel sensations from its +environment would create a grotesque monstrosity. One partial solution +to this problem is to connect the reverse-engineered brain to an +exoskeleton. If the exoskeleton acts like a surrogate, then the reverse- +engineered brain would be able to enjoy sensations such as touch and +sight without looking grotesque. Eventually the exoskeleton would go" +"wireless, so that it would act like a human but be controlled by a +reverse-engineered brain “living” inside a computer. + +This surrogate would have the best of both worlds. Being an +exoskeleton, it would be perfect. It would possess superpowers. Since it +would be wirelessly connected to a reverse-engineered brain inside a +large computer, it would also be immortal. And lastly, since it would +sense the environment and look appealingly like a real human, it would +not have as many problems interacting with humans, many of whom +will also have probably opted for this procedure. So the actual +connectome would reside in a stationary supercomputer, although its +consciousness would manifest itself in a perfect, mobile surrogate body. + +All this would require a level of technology far beyond anything that +is attainable today. However, given the rapid pace of scientific progress, +this could become a reality by the end of the century. + +GRADUAL TRANSFERENCE" +"GRADUAL TRANSFERENCE + +Right now the process of reverse engineering involves transferring the +information within the brain, neuron for neuron. The brain has to be cut +up into thin slices, since MRI scans are not yet refined enough to identify +the precise neural architecture of the living brain. So until that can be +done, the obvious disadvantage of this approach is that you have to die +before you can be reversed engineered. Since the brain degenerates +rapidly after death, its preservation would have to take place +immediately, which is very difficult to accomplish." +"But there may be one way to attain immortality without having to die +first. This idea was pioneered by Dr. Hans Moravec, former director of +the Artificial Intelligence Laboratory at Carnegie Mellon University. +When I interviewed him, he told me that he envisions a time in the +distant future when we will be able to reverse engineer the brain for a +specific purpose: to transfer the mind into an immortal robotic body +even while a person is still conscious. If we can reverse engineer every +neuron of the brain, why not create a copy made of transistors, +duplicating precisely the thought processes of the mind? In this way, you +do not have to die in order to live forever. You can be conscious +throughout the entire process." +"He told me that this process would have to be done in steps. First, you +lie on a stretcher, next to a robot lacking a brain. Next, a robotic surgeon +extracts a few neurons from your brain, and then duplicates these +neurons with some transistors located in the robot. Wires connect your +brain to the transistors in the robot’s empty head. The neurons are then + + thrown away and replaced by the transistor circuit. Since your brain +remains connected to these transistors via wires, it functions normally +and you are fully conscious during this process. Then the super surgeon +removes more and more neurons from your brain, each time duplicating +these neurons with transistors in the robot. Midway through the +operation, half of your brain is empty; the other half is connected by + +wires to a large collection of transistors inside the robot’s head. +Eventually all the neurons in your brain have been removed, leaving a +robot brain that is an exact duplicate of your original brain, neuron for +neuron." +"At the end of this process, however, you rise from the stretcher and +find that your body is perfectly formed. You are handsome and beautiful +beyond your dreams, with superhuman powers and abilities. As a perk, +you are also immortal. You gaze back at your original mortal body, +which is just an aging shell without a mind. + +This technology, of course, is far ahead of our time. We cannot reverse +engineer the human brain, let alone make a carbon copy made of +transistors. (One of the main criticisms of this approach is that a +transistorized brain may not fit inside the skull. In fact, given the size of +electronic components, the transistorized brain may be the size of a huge +supercomputer. In this sense, this proposal begins to resemble the +previous one, in which the reverse-engineered brain is stored in a huge +supercomputer, which in turn controls a surrogate. But the great +advantage of this approach is that you don’t have to die; you’d be fully +conscious during the process.)" +"One’s head spins contemplating these possibilities. All of them seem to +be consistent with the laws of physics, but the technological barriers to +achieving them are truly formidable. All these proposals for uploading +consciousness into a computer require a technology that is far into the +future. + +But there is one last proposal for attaining immortality that does not +require reverse engineering the brain at all. It requires simply a +microscopic “nanobot” that can manipulate individual atoms. So why +not live forever in your own natural body, but with a periodic “tune-up” +that makes it immortal? + +WHAT IS AGING? + +This new approach incorporates the latest research into the aging +process. Traditionally there has been no consensus among biologists + + about the source of the aging process. But within the last decade, a new +theory has gained gradual acceptance and has unified many strands of" +"research into aging. Basically, aging is the buildup of errors, at the +genetic and cellular level. As cells get older, errors begin to build up in +their DNA and cellular debris also starts to accumulate, which makes +cells sluggish. As cells begin to slowly malfunction, skin begins to sag, +bones become frail, hair falls out, and our immune system deteriorates. +Eventually, we die. + +But cells also have error-correcting mechanisms. Over time, however, +even these error-correcting mechanisms begin to fail, and aging +accelerates. The goal, therefore, is to strengthen the natural cell-repair +mechanisms, which can be done via gene therapy and the creation of +new enzymes. But there is also another way: using “nanobot” +assemblers." +"One of the linchpins of this futuristic technology is something called +the “nanobot,” or an atomic machine, which patrols the bloodstream, +zapping cancer cells, repairing the damage from the aging process, and +keeping us forever young and healthy. Nature has already created some +nanobots, in the form of immune cells that patrol the body in the blood. +But these immune cells attack viruses and foreign bodies, not the aging +process. + +Immortality is within reach if these nanobots can reverse the ravages +of the aging process at the molecular and cellular level. In this vision, +nanobots are like immune cells, tiny police patrolling your bloodstream. +They attack any cancer cells, neutralize viruses, and clean out the debris +and mutations. Then the possibility of immortality would be within +reach using our own bodies, not some robot or clone. + +NANOBOTS—REAL OR FANTASY?" +"NANOBOTS—REAL OR FANTASY? + +My own personal philosophy is that if something is consistent with the +laws of physics, then it becomes an engineering and economics problem +to build it. The engineering and economic hurdles may be formidable, of +course, making it impractical for the present, but nonetheless it is still +possible. + +On the surface, the nanobot is simple: an atomic machine with arms +and clippers that grabs molecules, cuts them at specific points, and then +splices them back together. By cutting and pasting various atoms, the" +"nanobot can create almost any known molecule, like a magician pulling +something out of a hat. It can also self-reproduce, so it is necessary to +build only one nanobot. This nanobot will then take raw materials, +digest them, and create millions of other nanobots. This could trigger a +second Industrial Revolution, as the cost of building materials plummets. +One day, perhaps every home will have its own personal molecular +assembler, so you can have anything you want just by asking for it." +"But the key question is: Are nanobots consistent with the laws of +physics? Back in 2001, two visionaries practically came to blows over +this crucial question. At stake was nothing less than a vision of the entire +future of technology. On one side was the late Richard Smalley, a Nobel +laureate in chemistry and skeptical of nanobots. On the other side was +Eric Drexler, one of the founding fathers of nanotechnology. Their +titanic, tit-for-tat battle played out in the pages of several scientific +magazines from 2001 to 2003." +"Smalley said that, at the atomic scale, new quantum forces emerge +that make nanobots impossible. The error made by Drexler and others, +he claimed, is that the nanobot, with its clippers and arms, cannot +function at the atomic scale. There are novel forces (e.g., the Casimir +force) that cause atoms to repel or attract one another. He called this the +“sticky, fat fingers” problem, because the fingers of the nanobot are not +like delicate, precise pliers and wrenches. Quantum forces get in the +way, so it’s like trying to weld metals together while wearing gloves that +are many inches thick. Furthermore, every time you try to weld two +pieces of metal together, these pieces are either repelled or stick to you, +so you can never grab one properly." +"Drexler then fired back, stating that nanobots are not science fiction— +they actually exist. Think of the ribosomes in our own body. They are +essential in creating and molding DNA molecules. They can cut and +splice DNA molecules at specific points, which makes possible the +creation of new DNA strands. + +But Smalley wasn’t satisfied, stating that ribosomes are not all-purpose +machines that can cut and paste anything you want; they work +specifically on DNA molecules. Moreover, ribosomes are organic +chemicals that need enzymes to speed up the reaction, which occurs +only in a watery environment. Transistors are made of silicon, not water, +so these enzymes would never work, he concluded. Drexel, in turn, + +mentioned that catalysts can work even without water. This heated +exchange went back and forth through several rounds. In the end, like +two evenly matched prizefighters, both sides seemed exhausted. Drexler +had to admit that the analogy to workers with cutters and blowtorches" +"was too simplistic, that quantum forces do get in the way sometimes. But +Smalley had to concede that he was unable to score a knockout blow. +Nature had at least one way of evading the “sticky, fat fingers” problem, +with ribosomes, and perhaps there might be other subtle, unforeseen +ways as well. + +Regardless of the details of this debate, Ray Kurzweil is convinced that +these nanobots, whether or not they have fat, sticky fingers, will one day +shape not just molecules, but society itself. He summarized his vision +when he said, “I’m not planning to die.... I see it, ultimately, as an +awakening of the whole universe. I think the whole universe right now is +basically made up of dumb matter and energy and I think it will wake +up. But if it becomes transformed into this sublimely intelligent matter +and energy, I hope to be part of that.”" +"As fantastic as these speculations are, they are only a preface to the +next leap in speculation. Perhaps one day the mind will not only be free +of its material body, it will also be able to explore the universe as a +being of pure energy. The idea that consciousness will one day be free to +roam among the stars is the ultimate dream. As incredible as it may +sound, this is well within the laws of physics. + +13 THE MIND AS PURE ENERGY + +The idea that one day consciousness may spread throughout the +universe has been considered seriously by physicists. Sir Martin Rees, the +Royal Astronomer of Great Britain, has written, “Wormholes, extra +dimensions, and quantum computers open up speculative scenarios that +could transform our entire universe eventually into a ‘living cosmos’!”" +"But will the mind one day be freed of its material body to explore the +entire universe? This was the theme explored in Isaac Asimov’s classic +science-fiction tale “The Last Question.” (He would fondly recall that this +was his favorite science-fiction short story of all the ones he had +written.) In it, billions of years into the future, humans will have placed +their physical bodies in pods on an obscure planet, freeing their minds to +control pure energy throughout the galaxy. Instead of surrogates made +of steel and silicon, these surrogates are pure energy beings that can +effortlessly roam the distant reaches of space, past exploding stars, +colliding galaxies, and other wonders of the universe. But no matter how +powerful humanity has become, it is helpless as it witnesses the ultimate +death of the universe itself in the Big Freeze. In desperation, humanity +constructs a supercomputer to answer the final question: Can the death" +"constructs a supercomputer to answer the final question: Can the death +of the universe be reversed? The computer is so large and complex that +it has to be placed in hyperspace. But the computer simply responds that +there is insufficient information to give an answer." +"Eons later, as the stars begin to turn dark, all life in the universe is +about to die. But then the supercomputer finally discovers a way to +reverse the death of the universe. It collects dead stars from across the +universe, combines them into one gigantic cosmic ball, and ignites it. As +the ball explodes, the supercomputer announces, “Let there be light!” + +And there was light. + +So humanity, once freed of the physical body, is capable of playing +God and creating a new universe. + +At first, Asimov’s fantastic tale of beings made of pure energy roaming + +across the universe sounds impossible. We are accustomed to thinking of +beings made of flesh and blood, which are at the mercy of the laws of +physics and biology, living and breathing on Earth, and bound by the +gravity of our planet. The concept of conscious entities of energy, +soaring across the galaxy, unimpeded by the limitations of material +bodies, is a strange one." +"Yet this dream of exploring the universe as beings of pure energy is +well within the laws of physics. Think of the most familiar form of pure +energy, a laser beam, which is capable of containing vast amounts of +information. Today trillions of signals in the form of phone calls, data +packages, videos, and e-mail messages are transmitted routinely by fiber¬ +optic cables carrying laser beams. One day, perhaps sometime in the +next century, we will be able to transmit the consciousness of our brains +throughout the solar system by placing our entire connectomes onto +powerful laser beams. A century beyond that, we may be able to send +our connectome to the stars, riding on a light beam." +"(This is possible because the wavelength of a laser beam is +microscopic, i.e., measured in millionths of a meter. That means you can +compress vast amounts of information on its wave pattern. Think of +Morse code. The dots and dashes of Morse code can easily be +superimposed on the wave pattern of a laser beam. Even more +information can be transferred onto a beam of X-rays, which has a +wavelength even smaller than an atom.) + +One way to explore the galaxy, unbound by the messy restrictions of +ordinary matter, is to place our connectomes onto laser beams directed +at the moon, the planets, and even the stars. Given the crash program to +find the pathways of the brain, the complete connectome of the human +brain will be available late in this century, and a form of the connectome +capable of being placed on a laser beam might be available in the next +century." +"The laser beam would contain all the information necessary to +reassemble a conscious being. Although it may take years or even +centuries for the laser beam to reach its destination, from the point of +view of the person riding on the laser beam, the trip would be +instantaneous. Our consciousness is essentially frozen on the laser beam +as it soars through empty space, so the trip to the other side of the +galaxy appears to take place in the blink of an eye." +"In this way, we avoid all the unpleasant features of interplanetary and +interstellar travel. First, there is no need to build colossal booster +rockets. Instead, you simply press the “on” button of a laser. Second, +there are no powerful g forces crushing your body as you accelerate into +space. Instead, you are boosted instantly to the speed of light, since you +are immaterial. Third, you don’t have to suffer the hazards of outer +space, such as meteor impacts and deadly cosmic rays, since asteroids +and radiation pass right through you harmlessly. Fourth, you don’t have +to freeze your body or endure years of boredom as you lumber tediously +inside a conventional rocket. Instead, you zip across space at the fastest +velocity in the universe, frozen in time." +"Once we reach our destination, there would have to be a receiving +station to transfer the data of the laser beam onto a mainframe +computer, which then brings the conscious being back to life. The code +that was imprinted onto the laser beam now takes control of the +computer and redirects its programming. The connectome directs the +mainframe computer to begin simulating the future to attain its goals +(i.e., it becomes conscious). + +This conscious being inside the mainframe then sends signals +wirelessly to a robotic surrogate body, which has been waiting for us at +the destination. In this way, we suddenly “wake up” on a distant planet +or star, as if the trip took place in the blink of an eye, inside the robotic +body of our surrogate. All the complex computations take place in a +large mainframe computer, which directs the movements of a surrogate +to carry on with our business on a distant star. We are oblivious to the +hazards of space travel, as if nothing had happened." +"Now imagine a vast network of these stations spread out over the solar +system and even the galaxy. From our point of view, hopping from star +to star would be almost effortless, traveling at the speed of light in +journeys that are instantaneous. At each station, there is a robotic +surrogate waiting for us to enter its body, just like an empty hotel room +waiting for us to check in. We arrive at our destination refreshed and +equipped with a superhuman body. + +The type of surrogate robotic body that awaits us at the end of this + + journey would depend on the mission. If the job is to explore a new +world, then the surrogate body would have to work in harsh conditions. +It would have to adjust to a different gravitational field, a poisonous + +atmosphere, freezing-cold or blistering-hot temperatures, different day- +night cycles, and a constant rain of deadly radiation. To survive under +these harsh conditions, the surrogate body would have to have super +strength and super senses." +"If the surrogate body is purely for relaxation, then it would be +designed for leisurely activities. It would maximize the pleasure of +soaring through space on skis, surfboards, kites, gliders, or planes, or of +sending a ball through space propelled by the swing of a bat, club, or +racket. + +Or if the job is to mingle with and study the local natives, then the +surrogate would approximate the bodily characteristics of the indigenous +population (as in the movie Avatar )." +"Admittedly, in order to create this network of laser stations in the first +place, it might be necessary first to travel to the planets and stars in the +old-fashioned way, in more conventional rocket ships. Then one could +build the first set of these laser stations. (Perhaps the fastest, cheapest, +and most efficient way of creating this interstellar network would be to +send self-replicating robotic probes throughout the galaxy. Because they +can make copies of themselves, starting with one such probe, after many +generations there would be billions of such probes streaming out in all +directions, each one creating a laser station wherever it lands. We will +discuss this further in the next chapter.) + +But once the network is fully established, one can conceive of a +continual stream of conscious beings roaming the galaxy, so that at any +time crowds of people are leaving and arriving from distant parts of the +galaxy. Any laser station in the network might look like Grand Central +Station." +"As futuristic as this may sound, the basic physics for this concept are +already well established. This includes placing vast amounts of data onto +laser beams, sending this information across thousands of miles, and +then decoding the information at the other end. The major problems +facing this idea are therefore not in the physics, but in the engineering. +Because of this, it may take us until the next century to send our entire +connectome on laser beams powerful enough to reach the planets. It +might take us still another century to beam our minds to the stars. + +To see if this is feasible, it is instructive to do a few simple, back-of- +the-envelope calculations. The first problem is that the photons inside a" +"pencil-thin laser beam, although they appear to be in perfectly parallel +formation, actually diverge slightly in space. (When I was a child, I used +to shine a flashlight at the moon and wonder if the light ever reached it. +The answer is yes. The atmosphere absorbs over 90 percent of the +original beam, leaving some remaining to reach the moon. But the real +problem is that the image the flashlight finally casts on the moon is +miles across. This is because of the uncertainty principle; even laser +beams must diverge slowly. Since you cannot know the precise location +of the laser beam, it must, by the laws of quantum physics, slowly spread +out over time.)" +"But beaming our connectomes to the moon does not give us much +advantage, since it’s easier simply to remain on Earth and control the +lunar surrogate directly by radio. The delay is only about a second when +issuing commands to the surrogate. The real advantage comes when +controlling surrogates on the planets, since a radio message may take +hours to reach a surrogate there. The process of issuing a series of radio +commands to a surrogate, waiting for a response, and issuing another +command would be painfully slow, taking days on end. + +If you want to send a laser beam to the planets, you first have to +establish a battery of lasers on the moon, well above the atmosphere, so +there is no air to absorb the signal. Shot from the moon, a laser beam to +the planets could arrive in a matter of minutes to a few hours. Once the +laser beam has sent the connectome to the planets, then it’s possible to +directly control the surrogate without any delay factors at all." +"So establishing a network of these laser stations throughout the solar +system could be accomplished by the next century. But the problems are +magnified when we try sending the beam to the stars. This means that +we must have relay stations placed on asteroids and space stations along +the way, in order to amplify the signal, reduce errors, and send the +message to the next relay station. This could potentially be done by +using the comets that lie between our sun and the nearby stars. For +example, extending about a light-year from the sun (or one-quarter of +the distance to the nearest star) is the Oort cloud of comets. It is a +spherical shell of billions of comets, many of which lie motionless in +empty space. There is probably a similar Oort cloud of comets +surrounding the Centauri star system, which is our nearest stellar +neighbor. Assuming that this Oort cloud also extends a light-year from" +"those stars, then fully half the distance from our solar system to the next +contains stationary comets on which we can build laser relay stations. + + Another problem is the sheer amount of data that must be sent by +laser beam. The total information contained in one’s connectome, +according to Dr. Sebastian Seung, is roughly one zettabyte (that is, a 1 +with twenty-one zeros after it). This is roughly equivalent to the total +information contained in the World Wide Web today. Now consider +shooting a battery of laser beams into space carrying this vast mountain +of information. Optical fibers can carry terabytes of data per second (a 1 +with twelve zeros after it). Within the next century, advances in +information storage, data compression, and bundling of laser beams may +increase this efficiency by a factor of a million. This means that it would +take a few hours or so to send the beam into space carrying all the +information contained within the brain." +"So the problem is not the sheer amount of data sent on laser beams. In +principle, laser beams can carry an unlimited amount of data. The real +bottlenecks are the receiving stations at either end, which must have +switches that rapidly manipulate this amount of data at blinding speed. +Silicon transistors may not be fast enough to handle this volume of data. +Instead, we might have to use quantum computers, which compute not +on silicon transistors but on individual atoms. At present, quantum +computers are at a primitive level, but by the next century they might be +powerful enough to handle zettabytes of information. + +FLOATING BEINGS OF ENERGY" +"FLOATING BEINGS OF ENERGY + +Another advantage of using quantum computers to process this +mountain of data is the chance to create beings of energy that can hover +and float in the air, which appear frequently in science fiction and +fantasy. These beings would represent consciousness in its purest form. +At first, however, they may seem to violate the laws of physics, since +light always travels at the speed of light. + +But in the last decade, headlines were made by physicists at Harvard +University who announced that they were able to stop a beam of light +dead in its tracks. These physicists apparently accomplished the +impossible, slowing down a light beam to a leisurely pace until it could" +"be placed in a bottle. Capturing a light beam in a bottle is not so +fantastic if you look carefully at a glass of water. As a light beam enters +the water, it slows down, bending as it enters the water at an angle. +Similarly, light bends as it enters glass, making telescopes and +microscopes possible. The reason for all this comes from the quantum +theory. + +Think of the old Pony Express, which delivered the mail in the" +"Think of the old Pony Express, which delivered the mail in the + + nineteenth century in the American West. Each pony could sprint +between relay stations at great speed. But the bottleneck was the delay +factor at each relay station, where the mail, rider, and pony had to be +exchanged. This slowed down the average velocity of the mail +considerably. In the same way, in the vacuum between atoms, light still +travels at c, the speed of light, which is roughly 186,282 miles per second. +However, when it hits atoms, light is delayed; it is briefly absorbed and +then reemitted by atoms, sending it on its way a fraction of a second +later. This slight delay is responsible for light beams, on average, +apparently slowing down in glass or water." +"The Harvard scientists exploited this phenomenon, taking a container +of gas and carefully cooling it down to near absolute zero. At these +freezing temperatures, the gas atoms absorbed a light beam for longer +and longer time periods before reemitting it. Thus, by increasing this +delay factor, they could slow down the light beam until it came to rest. +The light beam still traveled at the speed of light between the gas atoms, +but it spent an increasing amount of time being absorbed by them. + +This raises the possibility that a conscious being, instead of assuming +control of a surrogate, may prefer to remain in the form of pure energy +and roam, almost ghostlike, as pure energy." +"So in the future, as laser beams are sent to the stars containing our +connectomes, the beam may be transferred into a cloud of gas molecules +and then contained in a bottle. This “bottle of light” is very similar to a +quantum computer. Both of them have a collection of atoms vibrating in +unison, in which the atoms are in phase with one another. And both of +them can do complex computations that are far beyond an ordinary +computer’s capability. So if the problems of quantum computers can be +solved, it may also give us the ability to manipulate these “bottles of +light.” + +FASTER THAN LIGHT? + +We see, then, that all these problems are ones of engineering. There is no +law of physics preventing traveling on an energy beam in the next +century or beyond. So this is perhaps the most convenient way of +visiting the planets and stars. Instead of riding on a light beam, as the +poets dreamed, we become the light beam." +"To truly realize the vision expressed in Asimov’s science-fiction tale, +we need to ask if faster-than-light intergalactic travel is truly possible. In +his short story, beings of immense power move freely between galaxies +separated by millions of light-years. + + Is this possible? To answer this question, we have to push the very +boundaries of modern quantum physics. Ultimately, things called +“wormholes” may provide a shortcut through the vastness of space and +time. And beings made of pure energy rather than matter would have a +decisive advantage in passing through them." +"Einstein, in some sense, is like the cop on the block, stating that you +cannot go faster than light, the ultimate velocity in the universe. +Traveling across the Milky Way galaxy, for example, would take one +hundred thousand years, even sailing on a laser beam. Although only an +instant of time has passed for the traveler, the time on the home planet +has progressed one hundred thousand years. And passing between +galaxies involves millions to billions of light-years. + +But Einstein himself left a loophole in his work. In his general theory +of relativity of 1915, he showed that gravity arose from the warping of +space-time. Gravity is not the “pull” of a mysterious invisible force, as +Newton once thought, but actually a “push” caused by space itself +bending around an object. Not only did this brilliantly explain the +bending of starlight passing near stars and the expansion of the universe, +it left open the possibility of the fabric of space-time stretching until it +ripped." +"In 1935, Einstein and his student Nathan Rosen introduced the +possibility that two black-hole solutions could be joined back to back, +like Siamese twins, so if you fell into one black hole, you could, in +principle, pass out of the other one. (Imagine joining two funnels at their +ends. Water that drains through one funnel emerges from the other.) +This “wormhole,” also called the Einstein-Rosen Bridge, introduced the + +possibility of portals or gateways between universes. Einstein himself +dismissed the possibility that you could pass through a black hole, since +you would be crushed in the process, but several subsequent +developments have raised the possibility of faster-than-light travel +through a wormhole." +"First, in 1963, mathematician Roy Kerr discovered that a spinning +black hole does not collapse into a single dot, as previously thought, but +into a rotating ring, spinning so fast that centrifugal forces prevent it +from collapsing. If you fell through the ring, then you could pass into +another universe. The gravitational forces would be large, but not +infinite. This would be like Alice’s Looking Glass, where you could pass +your hand through the mirror and enter a parallel universe. The rim of +the Looking Glass would be the ring forming the black hole itself. Since +Kerr’s discovery, scores of other solutions of Einstein’s equations have +shown that you can, in principle, pass between universes without being +immediately crushed. Since every black hole seen so far in space is + + spinning rapidly (some of them clocked at one million miles per hour), +this means that these cosmic gateways could be commonplace." +"In 1988, physicist Dr. Kip Thorne of Cal Tech and his colleagues +showed that, with enough “negative energy,” it might be possible to +stabilize a black hole so that a wormhole becomes “transversable” (i.e., +you can freely pass through it both ways without being crushed). +Negative energy is perhaps the most exotic substance in the universe, +but it actually exists and can be created (in microscopic quantities) in +the laboratory. + +So here is the new paradigm. First, an advanced civilization would +concentrate enough positive energy at a single point, comparable to a +black hole, to open up a hole through space connecting two distant +points. Second, it would amass enough negative energy to keep the +gateway open, so that it is stable and does not close the instant you enter +it." +"We can now put this idea into proper perspective. Mapping the entire +human connectome should be possible late in this century. An +interplanetary laser network could be established early in the next +century, so that consciousness can be beamed across the solar system. No +new law of physics would be required. A laser network that can go +between the stars may have to wait until the century after that. But a + +civilization that can play with wormholes will have to be thousands of +years ahead of us in technology, stretching the boundaries of known +physics." +"All this, then, has direct implications for whether consciousness can +pass between universes. If matter comes close to a black hole, the gravity +becomes so intense that your body becomes “spaghettified.” The gravity +pulling on your leg is greater than the gravity pulling on your head, so +your body is stretched by tidal forces. In fact, as you approach the black +hole, even the atoms of your body are stretched until the electrons are +ripped from the nuclei, causing your atoms to disintegrate." +"(To see the power of tidal forces, just look at the tides of Earth and the +rings of Saturn. The gravity of the moon and sun exert a pull on Earth, +causing the oceans to rise several feet during high tide. And if a moon +comes too close to a giant planet like Saturn, the tidal forces will stretch +the moon and eventually tear it apart. The distance at which moons get +ripped apart by tidal forces is called the Roche limit. The rings of Saturn +lie exactly at the Roche limit, so they might have been caused by a moon +that wandered too close to the mother planet.) + +Even if we enter a spinning black hole and use negative energy to + + stabilize it, then, the gravity fields still might be so powerful that we’d +be spaghettified." +"stabilize it, then, the gravity fields still might be so powerful that we’d +be spaghettified. + +But here is where laser beams have an important advantage over +matter when passing through a wormhole. Laser light is immaterial, so it +cannot be stretched by tidal forces as it passes near a black hole. Instead, +light becomes “blue-shifted” (i.e., it gains energy and its frequency +increases). Even though the laser beam is distorted, the information +stored on it is untouched. For example, a message in Morse code carried +by a laser beam becomes compressed, but the information content +remains unchanged. Digital information is untouched by tidal forces. So +gravitational forces, which can be fatal to beings made of matter, may be +harmless to beings traveling on light beams. + +In this way, consciousness carried by a laser beam, because it is +immaterial, has a decisive advantage over matter in passing through a +wormhole." +"Laser beams have another advantage over matter when passing +through a wormhole. Some physicists have calculated that a microscopic +wormhole, perhaps the size of an atom, might be easier to create. Matter + +would not be able to pass through such a tiny wormhole. But X-ray +lasers, with a wavelength smaller than an atom, might possibly be able +to pass through without difficulty." +"Although Asimov’s brilliant short story was clearly a work of fantasy, +ironically a vast interstellar network of laser stations might already exist +within the galaxy, yet we are so primitive that we are totally unaware of +it. To a civilization thousands of years ahead of us, the technology to +digitalize their connectomes and send them to the stars would be child’s +play. In that case, it is conceivable that intelligent beings are already +zapping their consciousness across a vast network of laser beams in the +galaxy. Nothing we observe with our most advanced telescopes and +satellites prepares us to detect such an intergalactic network. + +Carl Sagan once lamented the possibility that we might live in a world +surrounded by alien civilizations and not have the technology to realize +it. + +Then the next question is: What lurks in the alien mind?" +"Then the next question is: What lurks in the alien mind? + +If we were to encounter such an advanced civilization, what kind of +consciousness might it have? One day, the destiny of the human race +may rest on answering this question. + + Sometimes I think that the surest sign that intelligent life exists +elsewhere in the universe is that none of it has tried to contact +us. + +—BILL WATTERSON + +Either intelligent life exists in outer space or it doesn’t. Either +thought is frightening. + +—ARTHUR C. CLARKE + +14 THE ALIEN MIND" +"—ARTHUR C. CLARKE + +14 THE ALIEN MIND + +In War of the Worlds by H. G. Wells, aliens from Mars attack Earth +because their home planet is dying. Armed with death rays and giant +walking machines, they quickly incinerate many cities and are on the +verge of seizing control of Earth’s major capitals. Just as the Martians +are crushing all signs of resistance and our civilization is about to be +reduced to rubble, they are mysteriously stopped cold in their tracks. +With all their advanced science and weaponry, they failed to factor in an +onslaught from the lowliest of creatures: our germs." +"That single novel created an entire genre, launching a thousand +movies like Earth vs. the Flying Saucers and Independence Day. Most +scientists cringe, however, when they see how the aliens are described. +In the movies, aliens are often depicted as creatures with some sense of +human values and emotions. Even with glowing green skin and huge +heads, they still look like us to a certain degree. They also tend to speak +perfect English. + +But, as many scientists have pointed out, we may have much more in +common with a lobster or a sea slug than we do with an alien from +space." +"As with silicon consciousness, alien consciousness will most likely +have the general features described in our space-time theory; that is, the +ability to make a model of the world and then calculate how it will +evolve in time to achieve a goal. But while robots can be programmed so +that they emotionally bond with humans and have goals compatible +with ours, alien consciousness may have neither. It’s likely to have its +own set of values and goals, independent of humanity. One can only +speculate what these might be. + +Physicist Dr. Freeman Dyson of the Institute for Advanced Study at + + Princeton was a consultant to the movie 2001 . When he finally saw the +movie, he was delighted, not because of its dazzling special effects, but +because it was the first Hollywood movie ever to present an alien" +"consciousness, with desires, goals, and intentions totally foreign to ours. +For the first time, the aliens were not simply human actors flailing +about, trying to act menacing in cheesy monster costumes. Instead, alien +consciousness was presented as something totally orthogonal to human +experience, something entirely outside our ken. + +In 2011, Stephen Hawking raised another question. The noted +cosmologist made headlines when he said that we must be prepared for +a possible alien attack. He said that if we ever encounter an alien +civilization, it will be more advanced than ours and hence will pose a +mortal threat to our very existence." +"We have only to see what happened to the Aztecs when they +encountered the bloodthirsty Hernan Cortes and his conquistadors to +imagine what might happen with such a fateful encounter. Armed with +technology that the Bronze Age Aztecs had never seen before, such as +iron swords, gunpowder, and the horse, this small band of cutthroats +was able to crush the ancient Aztec civilization in a matter of months in +1521. + +All this raises these questions: What will alien consciousness be like? +How will their thinking process and goals differ from ours? What do +they want? + +FIRST CONTACT IN THIS CENTURY + +This is not an academic question. Given the remarkable advances in +astrophysics, we may actually make contact with an alien intelligence in +the coming decades. How we respond to them could determine one of +the most pivotal events in human history. + +Several advances are making this day possible." +"Several advances are making this day possible. + +First, in 2011 the Kepler satellite, for the first time in history, gave +scientists a “census” of the Milky Way galaxy. After analyzing light from +thousands of stars, the Kepler satellite found that one in two hundred +might harbor an earthlike planet in the habitable zone. For the first time, +we can therefore calculate how many stars within the Milky Way galaxy +might be earthlike: about a billion. As we look at the distant stars, we +have genuine reason to wonder if anyone is looking back at us. + + So far, more than one thousand exoplanets have been analyzed in" +"So far, more than one thousand exoplanets have been analyzed in + +detail by earthbound telescopes. (Astronomers find them at the rate of +about two exoplanets per week.) Unfortunately, nearly all of them are +Jupiter-size planets, probably devoid of any earthlike creatures, but +there are a handful of “super earths,” rocky planets that are a few times +larger than Earth. Already, the Kepler satellite has identified about 2,500 +candidate exoplanets in space, a handful of which look very much like +Earth. These planets are at just the right distance from their mother stars +so that liquid oceans can exist. And liquid water is the “universal +solvent” that dissolves most organic chemicals like DNA and proteins." +"In 2013, NASA scientists announced their most spectacular discovery +using the Kepler satellite: two exoplanets that are near twins of Earth. +They are located 1,200 light-years away in the constellation Lyra. They +are only 60 percent and 40 percent larger than Earth. More important, +both lie within the habitable zone of their mother star, so there is a +possibility that they have liquid oceans. Of all the planets analyzed so +far, they are the closest to being mirror images of Earth. + +Furthermore, the Hubble Space Telescope has given us an estimate of +the total number of galaxies in the visible universe: one hundred billion. +Therefore, we can calculate the number of earthlike planets in the visible +universe: one billion times one hundred billion, or one hundred +quintillion earthlike planets." +"This is a truly astronomical number, so the odds of life existing in the +universe are astronomically large, especially when you consider that the +universe is 13.8 billion years old, and there has been plenty of time for +intelligent empires to rise—and perhaps fall. In fact, it would be more +miraculous if another advanced civilization did not exist. + +SETI AND ALIEN CIVILIZATIONS + +Second, radio telescope technology is becoming more sophisticated. So +far, only about one thousand stars have been closely analyzed for signs +of intelligent life, but in the coming decade this number could rise by a +factor of one million. + +Using radio telescopes to hunt for alien civilizations dates back to +1960, when astronomer Frank Drake initiated Project Ozma (after the +Queen of Oz), using the twenty-five-meter radio telescope in Green" +"Bank, West Virginia. This marked the birth of the SETI project (the +Search for Extraterrestrial Intelligence). Unfortunately, no signals from +aliens were picked up, but in 1971 NASA proposed Project Cyclops, +which was supposed to have 1,500 radio telescopes at a cost of $10 +billion. + +Not surprisingly, it never went anywhere. Congress was not amused. + +Funding did become available for a much more modest proposal: to +send a carefully coded message in 1971 to aliens in outer space. A coded +message containing 1,679 bits of information was transmitted via the +giant Arecibo radio telescope in Puerto Rico toward the Globular Cluster +Ml 3, about 25,100 light-years away. It was the world’s first cosmic +greeting card, containing relevant information about the human race. +But no reply message was received. Perhaps the aliens were not +impressed with us, or possibly the speed of light got in the way. Given +the large distances involved, the earliest date for a reply message would +be 52,174 years from now." +"Since then, some scientists have expressed misgivings about +advertising our existence to aliens in space, at least until we know their +intentions toward us. They disagree with the proponents of the METI +Project (Messaging to Extra-Terrestrial Intelligence) who actively +promote sending signals to alien civilizations in space. The reasoning +behind the METI Project is that Earth already sends vast amounts of +radio and TV signals into outer space, so a few more messages from the +METI Project will not make much difference. But the critics of METI +believe that we should not needlessly increase our chances of being +discovered by potentially hostile aliens." +"In 1995, astronomers turned to private sources to start the SETI +Institute in Mountain View, California, to centralize research and initiate +Project Phoenix, which is trying to study one thousand nearby sunlike +stars in the l,200-to-3,000-megahertz radio range. The equipment is so +sensitive that it can pick up the emissions from an airport radar system +two hundred light-years away. Since its founding, the SETI Institute has +scanned more than one thousand stars at a cost of $5 million per year, +but still no luck. + +A more novel approach is the SETI@home project, initiated by +astronomers at the University of California at Berkeley in 1999, which +uses an informal army of millions of amateur PC owners. Anyone can + +join in this historic hunt. While you are sleeping at night, your screen +saver crunches some of the data pouring in from the Arecibo radio +telescope in Puerto Rico. So far, it has signed up 5.2 million users in 234 +countries; perhaps these amateurs dream that they will be the first in" +"human history to make contact with alien life. Like Columbus’s, their +names may go down in history. The SETI @home project has grown so +rapidly that it is, in fact, the largest computer project of this type ever +undertaken. + +When I interviewed Dr. Dan Wertheimer, director of SETI@home, I +asked him how they can distinguish false messages from real ones. He +said something that surprised me. He told me that they sometimes +deliberately “seed” the data from radio telescopes with fake signals from +an imaginary intelligent civilization. If no one picks up these fake +messages, then they know that there is something wrong with their +software. The lesson here is that if your PC screen saver announces that +it has deciphered a message from an alien civilization, please do not +immediately call the police or the president of the United States. It might +be a fake message. + +ALIEN HUNTERS" +"ALIEN HUNTERS + +One colleague of mine who has dedicated his life to finding intelligent +life in outer space is Dr. Seth Shostak, director of the SETI Institute. With +his Ph.D. in physics from the California Institute of Technology, I might +have expected him to become a distinguished physics professor lecturing +to eager Ph.D. students, but instead he spends his time in an entirely +different fashion: asking for donations to the SETI Institute from wealthy +individuals, poring over possible signals from outer space, and doing a +radio show. I once asked him about the “giggle factor”—do fellow +scientists giggle when he tells them that he listens to aliens from outer +space? Not anymore, he claims. With all the new discoveries in +astronomy, the tide has turned." +"In fact, he even sticks his neck out and says flatly that we will make +contact with an alien civilization in the very near future. He has gone on +record as proclaiming that the 350-antenna Allen Telescope Array now +being built “will trip across a signal by the year 2025.” + +Isn’t that a bit risky, I asked him? What makes him so sure? One factor +working in his favor has been the explosion in the number of radio +telescopes in the last few years. Although the U.S. government does not +fund his project, the SETI Institute recently hit pay dirt when it +convinced Paul Allen (the Microsoft billionaire) to donate over $30 +million in funds to start the Allen Telescope Array at Hat Creek, +California, 290 miles north of San Francisco. It currently scans the +heavens with 42 radio telescopes, and eventually will reach up to 350. +(One problem, however, is the chronic lack of funding for these scientific +experiments. To make up for budget cuts, the Hat Creek facility is kept" +"alive through partial funding from the military.) + +One thing, he confessed to me, makes him squirm a bit, and that is +when people confuse the SETI Project with UFO hunters. The former, he +claims, is based on solid physics and astronomy, using the latest in +technology. The latter, however, base their theories on anecdotal +hearsay evidence that may or may not be based on truth. The problem is +that the mass of UFO sightings he gets in the mail are not reproducible +or testable. He urges anyone who claims to have been abducted by aliens +in a flying saucer to steal something—an alien pen or paperweight, for +example—to prove your case. Never leave a UFO empty-handed, he told +me." +"He also concludes that there is no firm evidence that aliens have +visited our planet. I then asked him whether he thought the U.S. +government was deliberately covering up evidence of an alien +encounter, as many conspiracy theorists believe. He replied, “Would +they really be so efficient at covering up a big thing like this? +Remember, this is the same government that runs the post office.” + +DRAKE’S EQUATION + +When I asked Dr. Wertheimer why he is so sure that there is alien life in +outer space, he replied that the numbers are in his favor. Back in 1961, +astronomer Frank Drake tried to estimate the number of such intelligent +civilizations by making plausible assumptions. If we start with the +number one hundred billion, the number of stars in the Milky Way +galaxy, then we can estimate the fraction of them that are similar to our" +"sun. We can reduce that number further by estimating the fraction of +them that have planets, the fraction of them that have earthlike planets, +etc. After making a number of reasonable assumptions, we come up with +an estimate of ten thousand advanced civilizations in our own Milky +Way galaxy. (Carl Sagan, with a different set of estimates, came up with +the number one million.)" +"Since then, scientists have been able to make much better estimates of +the number of advanced civilizations in our galaxy. For example, we +know there are more planets orbiting stars than Drake originally +expected, and more earthlike planets as well. But we still face a problem. +Even if we know how many earthlike twins there are in space, we still +don’t know how many of them support intelligent life. Even on Earth, it +took 4.5 billion years before intelligent beings (us) finally arose from the +swamp. For about 3.5 billion years, life-forms have existed on Earth, but +only in the last one hundred thousand years or so have intelligent beings + + like us emerged. So even on an earthlike planet like Earth itself, the rise +of truly intelligent life has been very difficult. + +WHY DON’T THEY VISIT US?" +"WHY DON’T THEY VISIT US? + +But then I asked Dr. Seth Shostak of SETI this killer question: If there are +so many stars in the galaxy, and so many alien civilizations, then why +don’t they visit us? This is the Fermi paradox, named for Enrico Fermi, +the Nobel laureate who helped build the atomic bomb and unlocked the +secrets of the nucleus of the atom. + +Many theories have been proposed. For one, the distance between +stars might be too great. It would take about seventy thousand years for +our most powerful chemical rockets to reach the stars nearest to Earth. +Perhaps a civilization thousands to millions of years more advanced than +ours may solve this problem, but there’s another possibility. Maybe they +annihilated themselves in a nuclear war. As John F. Kennedy once said, +“I am sorry to say there is too much point to the wisecrack that life is +extinct on other planets because their scientists were more advanced +than ours.”" +"But perhaps the most logical reason is this: Imagine walking down a +country road and encountering an ant hill. Do we go down to the ants + +and say, “I bring you trinkets. I bring you beads. I give you nuclear +energy. I will create an ant paradise for you. Take me to your leader”? + +Probably not. + +Now imagine that workers are building an eight-lane superhighway +next to the anthill. Would the ants know what frequency the workers are +talking on? Would they even know what an eight-lane superhighway +was? In the same fashion, any intelligent civilization that can reach +Earth from the stars would be thousands of years to millions of years +ahead of us, and we may have nothing to offer them. In other words, we +are arrogant to believe that aliens will travel trillions upon trillions of +miles just to see us. + +More than likely, we are not on their radar screen. Ironically, the +galaxy could be teaming with intelligent life-forms and we are so +primitive that we are oblivious of them. + +FIRST CONTACT" +"FIRST CONTACT + + But assume for the moment that the time will come, perhaps sooner +rather than later, when we make contact with an alien civilization. This +moment could be a turning point in the history of humanity. So the next +questions are: What do they want, and what will their consciousness be +like? + +In the movies and in science-fiction novels, the aliens often want to +eat us, conquer us, mate with us, enslave us, or strip our planet of +valuable resources. But all this is highly improbable. + +Our first contact with an alien civilization will probably not begin +with a flying saucer landing on the White House lawn. More likely, it +will happen when some teenager, running a screen saver from the +SETI@home project, announces that his or her PC has decoded signals +from the Arecibo radio telescope in Puerto Rico. Or perhaps when the +SETI project at Hat Creek detects a message that indicates intelligence." +"Our first encounter will therefore be a one-way event. We will be able +to eavesdrop on intelligent messages, but a return message may take +decades or centuries to reach them. + +The conversations that we hear on the radio may give us valuable +insight into this alien civilization. But most of the message will likely be + +gossip, entertainment, music, etc., with little scientific content. + +Then I asked Dr. Shostak the next key question: Will you keep it a +secret once First Contact is made? After all, won’t it cause mass panic, +religious hysteria, chaos, and spontaneous evacuations? I was a bit +surprised when he said no. They would give all the data to the +governments of the world and to the people. + +The next questions are: What will they be like? How do they think? + +To understand alien consciousness, perhaps it is instructive to analyze +another consciousness that is quite alien to us, the consciousness of +animals. We live with them, yet we are totally ignorant of what goes on +in their minds." +"Understanding animal consciousness, in turn, may help us understand +alien consciousness. + +ANIMAL CONSCIOUSNESS + + Do animals think? And if so, what do they think about? This question +has perplexed the greatest minds in history for thousands of years. The +Greek writers and historians Plutarch and Pliny both wrote about a +famous question that remains unsolved even today. Over the centuries, +many solutions have been given by the giants of philosophy. + +A dog is traveling down a road, looking for its master, when it +encounters a fork that branches in three directions. The dog first takes +the left path, sniffs around, and then returns, knowing that his master +has not taken that road. Then it takes the right path, sniffs, and realizes +that his master has not taken this road either. But this time, the dog +triumphantly takes the middle road, without sniffing." +"What was going on in the dog’s mind? Some of the greatest +philosophers have tackled this question, to no avail. The French +philosopher and essayist Michel de Montaigne wrote that the dog +obviously concluded that the only possible solution was to take the +middle road, a conclusion showing that dogs are capable of abstract +thought. + +But St. Thomas Aquinas, arguing in the thirteenth century, said the +opposite—that the appearance of abstract thought is not the same thing +as genuine thinking. We can be fooled by superficial appearances of + +intelligence, he claimed. + +Centuries later, there was also a famous exchange between John Locke +and George Berkeley about animal consciousness. “Beasts abstract not,” +proclaimed Locke flatly. To which Bishop Berkeley responded, “If the +fact that brutes abstract not be made the distinguishing property of that +sort of animal, I fear a great many of those that pass for man must be +reckoned into their number.”" +"Philosophers down the ages have tried to analyze this question in the +same manner: by imposing human consciousness on the dog. This is the +mistake of anthropomorphism, or assuming that animals think and +behave like us. But perhaps the real solution might be to look at this +question from the dog’s point of view, which could be quite alien. + +In Chapter 2, I gave a definition of consciousness in which animals +were part of a continuum of consciousness. Animals can differ from us in +the parameters they use to create a model of the world. Dr. David +Eagleman says that psychologists call this “umwelt,” or the reality +perceived by other animals. He notes, “In the blind and deaf world of the +tick, the important signals are temperature and the odor of butyric acid. +For the black ghost knifefish, it’s electrical fields. For the echo locating +bat, air-compressed waves. Each organism inhabits its own umwelt, + + which it presumably assumes to be the entire objective reality ‘out +there.’ ”" +"which it presumably assumes to be the entire objective reality ‘out +there.’ ” + +Consider the brain of a dog, which is constantly living in a swirl of +odors, by which it hunts for food or locates a mate. From these smells, +the dog then constructs a mental map of what exists in its surroundings. +This map of smells is totally different from the one we get from our eyes +and conveys an entirely different set of information. (Recall from +Chapter 1 that Dr. Penfield constructed a map of the cerebral cortex, +showing the distorted self-image of the body. Now imagine a Penfield +diagram of a dog’s brain. Most of it would be devoted to its nose, not its +fingers. Animals would have a totally different Penfield diagram. Aliens +in space would likely have an even stranger Penfield diagram.)" +"Unfortunately, we tend to assign human consciousness to animals, +even though animals may have a totally different world outlook. For +example, when a dog faithfully follows its master’s orders, we +subconsciously assume that the dog is man’s best friend because he likes +us and respects us. But since the dog is descended from Cards lupus (the + +gray wolf), which hunts in packs with a rigid pecking order, more than +likely the dog sees you as some sort of alpha male, or the leader of the +pack. You are, in some sense, the Top Dog. (This is probably one reason +why puppies are much easier to train than older dogs; it is likely easier +to imprint one’s presence on a puppy’s brain, while more mature dogs +realize that humans are not part of their pack.)" +"Also, when a cat enters a new room and urinates all over the carpet, +we assume that the cat is angry or nervous, and we try to find out the +reason why the cat is upset. But perhaps the cat is simply marking its +territory with the smell of its urine to ward off other cats. So the cat is +not upset at all; it’s simply warning other cats to stay out of the house, +because the house belongs to it. + +And if the cat purrs and rubs itself against your legs, we assume that it +is grateful to you for taking care of it, that this is a sign of warmth and +affection. More than likely, the cat is rubbing its hormone onto you to +claim ownership of its possession (i.e., you), to ward off other cats. In +the cat’s viewpoint, you are a servant of some sort, trained to give it +food several times a day, and rubbing its scent on you warns other cats +to stay away from this servant." +"As the sixteenth-century philosopher Michel de Montaigne once wrote, +“When I play with my cat, how do I know that she is not playing with +me rather than I with her?” + +And if the cat then stalks off to be alone, it is not necessarily a sign of +anger or aloofness. The cat is descended from the wildcat, which is a + + solitary hunter, unlike the dog. There is no alpha male to slobber over, +as in the case of the dog. The proliferation of various “animal whisperer” +programs on TV is probably a sign of the problems we encounter when +we force human consciousness and intentions onto animals." +"A bat would also have a much different consciousness, which would +be dominated by sounds. Almost blind, the bat requires constant +feedback from tiny squeaks it makes, which allow it to locate insects, +obstacles, and other bats via sonar. The Penfield map of its brain would +be quite alien to us, with a huge portion devoted to its ears. Similarly, +dolphins have a different consciousness than humans, which is also +based on sonar. Because dolphins have a smaller frontal cortex, it was +once thought that they were not so intelligent, but the dolphin +compensates for this by having a larger brain mass. If you unfold the + +neocortex of the dolphin brain, it would cover six magazine pages, while +if you unfold the neocortex of a human, it would measure only four +magazine pages. Dolphins also have very well-developed parietal and +temporal cortices to analyze sonar signals in the water and are one of +the few animals that can recognize themselves in a mirror, probably +because of this fact." +"In addition, the dolphin brain is actually structured differently from +humans’ because dolphin and human lineages diverged about ninety-five +million years ago. Dolphins have no need for a nose, so their olfactory +bulb disappears soon after birth. But thirty million years ago, their +auditory cortex exploded in size because dolphins learned to use +echolocation, or sonar, to find food. Like bats’, their world must be one +of whirling echoes and vibrations. Compared to humans, dolphins have +an extra lobe in their limbic system, called the “paralimbic” region, +which probably helps them forge strong social relations." +"Meanwhile, dolphins also have a language that is intelligent. I once +swam in a pool of dolphins for a TV special for the Science Channel. I +put sonar sensors in the pool that could pick up the clicks and whistles +used by dolphins to talk to one another. These signals were recorded and +then analyzed by computer. There is a simple way to discern if there is +an intelligence lurking among this random set of squeals and chirps. In +the English language, for example, the letter e is the most commonly +used letter of the alphabet. In fact, we can create a list of all the letters +of the alphabet and how frequently they occur. No matter what book in +English we analyze by computer, it will roughly obey the same list of +commonly found letters of the alphabet. + +Similarly, this computer program can be used to analyze the dolphins’ +language. Sure enough, we find a similar pattern indicating intelligence. +However, as we go to other mammals, the pattern begins to break down," +"and it finally collapses completely as we approach lower animals with +small brain sizes. Then the signals become nearly random. + +INTELLIGENT BEES? + +To get a sense of what alien consciousness might be like, consider the +strategies adopted by nature to reproduce life on Earth. There are two + +basic reproductive strategies nature has taken, with profound +implications for evolution and consciousness. + +The first, the strategy used by mammals, is to produce a small number +of young offspring and then carefully nurse each one to maturity. This is +a risky strategy, because only a few progeny are produced in each +generation, so it assumes that nurturing will even out the odds. This +means that every life is cherished and carefully nurtured for a length of +time." +"But there is another, much older strategy that is used by much of the +plant and animal kingdom, including insects, reptiles, and most other +life-forms on Earth. This involves creating a large number of eggs or +seeds and then letting them fend for themselves. Without nurturing, +most of the offspring never survive, so only a few hardy individuals will +make it into the next generation. This means that the energy invested in +each generation by the parents is nil, and reproduction relies on the law +of averages to propagate the species." +"These two strategies produce startlingly different attitudes toward life +and intelligence. The first strategy treasures each and every individual. +Love, nurturing, affection, and attachment are at a premium in this +group. This reproductive strategy can work only if the parents invest a +considerable amount of precious energy to preserve their young. The +second strategy, however, does not treasure the individual at all, but +rather emphasizes the survival of the species or group as a whole. To +them, individuality means nothing." +"Furthermore, reproductive strategy has profound implications for the +evolution of intelligence. When two ants meet each other, for example, +they exchange a limited amount of information using chemical scents +and gestures. Although the information shared by two ants is minimal, +with this information they are capable of creating elaborate tunnels and +chambers necessary to build an anthill. Similarly, although honeybees +communicate with one another by performing a dance, they can +collectively create complex honeycombs and locate distant flower beds. +So their intelligence arises not so much from the individual, but from the + + holistic interaction of the entire colony and from their genes. + +So consider an intelligent extraterrestrial civilization based on the +second strategy, such as an intelligent race of honeybees. In this society, +the worker bees that fly out each day in search of pollen are expendable." +"Worker bees do not reproduce at all, but instead live for one purpose, to +serve the hive and the queen, for which they willingly sacrifice +themselves. The bonds that link mammals together mean nothing to +them. + +Hypothetically, this might affect the development of their space +program. Since we treasure the life of every astronaut, considerable +resources are devoted to bringing them back alive. Much of the cost of +space travel goes into life support so the astronauts can make the return +voyage home and reenter the atmosphere. But for a civilization of +intelligent honeybees, each worker’s life may not be worth that much, so +their space program would cost considerably less. Their workers would +not have to come back. Every voyage might be a one-way trip, and that +would represent significant savings." +"Now imagine if we were to encounter an alien from space that was +actually similar to a honeybee worker. Normally, if we encounter a +honeybee in the forest, chances are it will completely ignore us, unless +we threaten it or the hive. It’s as if we did not exist. Similarly, this +worker would most likely not have the slightest interest in making +contact with us or sharing its knowledge. It would go on with its primary +mission and ignore us. Moreover, the values that we cherish would mean +little to it. + +Back in the 1970s, there were two medallions put aboard the Pioneer +10 and 11 probes, containing crucial information about our world and +society. The medallions exalted the diversity and richness of life on +Earth. Scientists back then assumed that alien civilizations in space +would be like us, curious and interested in making contact. But if such +an alien worker bee were to find our medallion, chances are that it +would mean nothing to it." +"Furthermore, each worker need not be very intelligent. They need to +be only intelligent enough to serve the interest of the hive. So if we were +to send a message to a planet of intelligent bees, chances are that they +would show little interest in sending a message back. + +Even if contact could be made with such a civilization, it might be +difficult communicating with them. For example, when we communicate +with one another, we break ideas down into sentences, with a subject- +verb structure, in order to build a narrative, often a personal story. Most + + of our sentences have the following structure: “I did this” or “They did + +that.” In fact, most of our literature and conversations use storytelling, +often involving experiences and adventures that we or our role models +have had. This presupposes that our personal experiences are the +dominant way to convey information." +"However, a civilization based on intelligent honeybees may not have +the least interest in personal narratives and storytelling. Being highly +collective, their messages may not be personal, but matter-of-fact, +containing vital information necessary for the hive rather than personal +trivia and gossip that might advance an individual’s social position. In +fact, they might find our storytelling language to be a bit repulsive, since +it puts the role of the individual before the needs of the collective. + +Also, worker bees would have a totally different sense of time. Since +worker bees are expendable, they might not have a long life span. They +might only take on projects that are short and well defined." +"However, humans live much longer, but we also have a tacit sense of +time; we take on projects and occupations that we can reasonably see to +the end within our lifetimes. We subconsciously pace our projects, our +relations with others, and our goals to accommodate a finite life span. In +other words, we live our lives in distinct phases: being single, married, +raising children, and eventually retiring. Often without being conscious +of it, we assume that we will live and eventually die within a finite time +frame." +"But imagine beings that can live for thousands of years, or are perhaps +immortal. Their priorities, their goals, and their ambitions would be +completely different. They could take on projects that would normally +require scores of human lifetimes. Interstellar travel is often dismissed as +pure science fiction because, as we have seen, the time it takes for a +conventional rocket to reach nearby stars is roughly seventy thousand +years. For us, this is prohibitively long. But for an alien life-form, that +time may be totally irrelevant. For example, they might be able to +hibernate, slow down their metabolism, or simply live for an indefinite +amount of time. + +WHAT DO THEY LOOK LIKE? + +Our first translations of these alien messages will probably give us some" +"Our first translations of these alien messages will probably give us some + + insight into the aliens’ culture and way of life. For example, it is likely +that the aliens will have evolved from predators and hence still share +some of their characteristics. (In general, predators on Earth are smarter +than prey. Hunters like tigers, lions, cats, and dogs use their cunning to +stalk, ambush, and hide, all of which require intelligence. All these +predators have eyes on the front of the face, for stereo vision as they +focus their attention. Prey, which have eyes to the sides of the face to +spot a predator, have only to run. That is why we say “sly as a fox” and +“dumb bunny.”) The alien life-forms may have outgrown many of the +predator instincts of their distant ancestors, but it is likely that they will +still have some of a predator’s consciousness (i.e., territoriality, +expansion, and violence when necessary)." +"If we examine the human race, we see that there were at least three +basic ingredients that set the stage for our becoming intelligent: + +1 . the opposable thumb, which gives us the ability to manipulate and + +reshape our environment via tools + +2. stereo eyes or the 3-D eyes of a hunter + +3. language, which allows us to accumulate knowledge, culture, and + +wisdom across generations + +When we compare these three ingredients with the traits found in the +animal kingdom, we see that very few animals meet these criteria for +intelligence. Cats and dogs, for example, do not have grasping ability or +a complex language. Octopi have sophisticated tentacles, but they don’t +see well and don’t have a complex language." +"There may be variations of these three criteria. Instead of an +opposable thumb, an alien might have claws or tentacles. (The only +prerequisite is that they should be able to manipulate their environment +with tools created by these appendages.) Instead of having two eyes, +they may have many more, like insects. Or they may have sensors that +detect sound or UV light rather than visible light. More than likely, they +will have the stereo eyes of a hunter, because predators generally have a +higher level of intelligence than prey. Also, instead of a language based +on sounds, they may communicate via different forms of vibrations. (The +only requirement is that they exchange information among themselves to + +create a culture spanning many generations.) + +But beyond these three criteria, anything goes." +"Next, the aliens may have a consciousness colored by their +environment. Astronomers now realize that the most plentiful habitat for +life in the universe may not be earthlike planets, where they can bask in +the warm sunlight of the mother star, but on icy-cold satellites orbiting +Jupiter-size planets billions of miles from the star. It is widely believed +that Europa, an ice-covered moon of Jupiter, has a liquid ocean beneath +the icy surface, heated by tidal forces. Because Europa tumbles as it +orbits Jupiter, it is squeezed in different directions by the huge +gravitational pull of Jupiter, which causes friction deep inside the moon. +This generates heat, forming volcanoes and ocean vents that melt the ice +and create liquid oceans. It is estimated that the oceans of Europa are +quite deep, and that their volume may be many times the volume of the +oceans of Earth. Since 50 percent of all stars in the heavens may have +Jupiter-size planets (a hundred times more plentiful than earthlike" +"Jupiter-size planets (a hundred times more plentiful than earthlike +planets), the most plentiful form of life may be on the icy moons of gas +giants like Jupiter." +"Therefore, when we encounter our first alien civilization in space, +more than likely it will have an aquatic origin. (Also, it is likely that +they will have migrated from the ocean and learned to live on the icy +surface of their moon away from the water, for several reasons. First, +any species that lives perpetually under the ice will have a quite limited +view of the universe. They will never develop astronomy or a space +program if they think that the universe is just the ocean underneath the +ice cover. Second, because water short-circuits electrical components, +they will never develop radio or TV if they stay underwater. If this +civilization is to advance, it must master electronics, which cannot exist +in the oceans. So, most likely, these aliens will have learned to leave the +oceans and survive on the land, as we did.)" +"But what happens if this life-form evolves to create a space-faring +civilization, capable of reaching Earth? Will they still be biological +organisms like us, or will they be post-biological? + +THE POST-BIOLOGICAL ERA + +One person who has spent considerable time thinking about these +questions is my colleague Dr. Paul Davies of Arizona State University, +near Phoenix. When I interviewed him, he told me that we have to +expand our own horizon to contemplate what a civilization that is +thousands or more years ahead of us may look like. + +Given the dangers of space travel, he believes that such beings will +have abandoned their biological form, much like the bodiless minds we +considered in the previous chapter. He writes, “My conclusion is a +startling one. I think it very likely—in fact inevitable—that biological" +"intelligence is only a transitory phenomenon, a fleeting phase in the +evolution of intelligence in the universe. If we ever encounter +extraterrestrial intelligence, I believe it is overwhelmingly likely to be +post-biological in nature, a conclusion that has obvious and far-reaching +ramifications for SETI.” + +In fact, if the aliens are thousands of years ahead of us, chances are +that they have abandoned their biological bodies eons ago to create the +most efficient computational body: a planet whose entire surface is +completely covered with computers. Dr. Davies says, “It isn’t hard to +envision the entire surface of a planet being covered with a single +integrated processing system.... Ray Bradbury has coined the term +‘Matrioshka brains’ for these awesome entities.”" +"So to Dr. Davies, alien consciousness may lose the concept of “self” +and be absorbed into the collective World Wide Web of Minds, which +blankets the entire surface of the planet. Dr. Davies adds, “A powerful +computer network with no sense of self would have an enormous +advantage over human intelligence because it could redesign ‘itself,’ +fearlessly make changes, merge with whole systems, and grow. ‘Feeling +personal’ about it would be a distinct impediment to progress.” + +So in the name of efficiency and increased computational ability, he +envisions members of this advanced civilization giving up their identity +and being absorbed into a collective consciousness. + +Dr. Davies acknowledges that critics of his idea may find this concept +rather repulsive. It appears as if this alien species is sacrificing +individuality and creativity to the greater good of the collective or the +hive. This is not inevitable, he cautions, but it is the most efficient +option for civilization." +"Dr. Davies also has a conjecture that he admits is rather depressing. + +When I asked him why these civilizations don’t visit us, he gave me a +strange answer. He said that any civilization that advanced would also +have developed virtual realities far more interesting and challenging +than reality. The virtual reality of today would be a children’s toy +compared to the virtual reality of a civilization thousands of years more +advanced than us. + +This means that perhaps their finest minds might have decided to play +out imaginary lives in different virtual worlds. It’s a discouraging +thought, he admitted, but certainly a possibility. In fact, it might even be +a warning for us as we perfect virtual reality. + + WHAT DO THEY WANT?" +"WHAT DO THEY WANT? + +In the movie The Matrix, the machines take over and put humans into +pods, where they exploit us as batteries to energize themselves. That is +why they keep us alive. But since a single electrical plant produces more +power than the bodies of millions of humans, any alien looking for an +energy source would quickly see there is no need for human batteries. +(This seems to be lost on the machine overlords in the Matrix, but +hopefully aliens would see reason.)" +"Another possibility is that they might want to eat us. This was +explored in an episode of The Twilight Zone, in which aliens land on +Earth and promise us the benefits of their advanced technology. They +even ask for volunteers to visit their beautiful home planet. The aliens +accidentally leave behind a book, called To Serve Man, which scientists +anxiously try to decipher in order to discover what wonders the aliens +will share with us. Instead, the scientists find out that the book is +actually a cookbook. (But since we will be made of entirely different +DNA and proteins from theirs, we could be difficult for their digestive +tracts to process.)" +"Another possibility is that the aliens will want to strip Earth of +resources and valuable minerals. There may be some truth to this +argument, but if the aliens are advanced enough to travel effortlessly +from the stars, then there are plenty of uninhabited planets to plunder +for resources, without having to worry about restive natives. From their +point of view, it would be a waste of time to try to colonize an inhabited + +planet when there are easy alternatives." +"planet when there are easy alternatives. + +So if the aliens do not want to enslave us or plunder our resources, +then what danger do they pose? Think of deer in a forest. Whom should +they fear the most—the ferocious hunter armed with a shotgun, or the +mild-mannered developer armed with a blueprint? Although the hunter +may scare the deer, only a few deer are threatened by him. More +dangerous to the deer is the developer, because the deer are not even on +his radar screen. The developer may not even think about the deer at all, +concentrating instead on developing the forest into usable property. In +view of this, what would an invasion actually look like?" +"In Hollywood movies, there is one glaring flaw: the aliens are only a +century or so ahead of us, so we can usually devise a secret weapon or +exploit a simple weakness in their armor to fight them off, as in Earth vs. +the Flying Saucers. But as SETI director Dr. Seth Shostak once told me, a +battle with an advanced alien civilization will be like a battle between +Bambi and Godzilla. + + In reality, the aliens might be millennia to millions of years ahead of +us in their weaponry. So, for the most part, there will be little we can do +to defend ourselves. But perhaps we can learn from the barbarians who +defeated the greatest military empire of its time, the Roman Empire. + +The Romans were masters of engineering, able to create weapons that +could flatten barbarian villages and roads to supply distant military +outposts of a vast empire. The barbarians, who were barely emerging +from a nomadic existence, had little chance when encountering the +juggernaut of the Roman Imperial Army." +"But history records that as the empire expanded, it was spread too +thin, with too many battles to fight, too many treaties bogging it down, +and not enough of an economy to support all this, especially with a +gradual decline in population. Moreover, the empire, always short on +recruits, had to enlist young barbarian soldiers and promote them to +leadership positions. Inevitably, the superior technology of the empire +began to filter down to the barbarians as well. In time, the barbarians +began to master the very military technologies that at first had +conquered them. + +Toward the end, the empire, weakened by internal palace intrigues, +severe crop shortages, civil wars, and an overstretched army, faced +barbarians who were able to fight the Roman Imperial Army to a + +standstill. The sacking of Rome in A.D. 410 and 455 paved the way for +the empire’s ultimate fall in A.D. 476." +"In the same way, it is likely that earthlings will initially offer no real +threat to an alien invasion, but over time earthlings could learn the weak +points of the alien army, its power supplies, its command centers, and +most of all its weaponry. In order to control the human population, the +aliens will have to recruit collaborators and promote them. This will +result in a diffusion of their technology to the humans. + +Then a ragtag army of earthlings might be able to mount a +counterattack. In Eastern military strategy, like the classic teachings of +Sun Tzu in The Art of War, there is a way to defeat even a superior army. +You first allow it to enter your territory. Once it has entered unfamiliar +land and its ranks are diffused, you can counterattack where they are +weakest." +"Another technique is to use the enemy’s strength against it. In judo, +the principal strategy is to turn the momentum of the attacker to your +advantage. You let the enemy attack, and then trip them or throw them +off guard, exploiting the enemy’s own mass and energy. The bigger they + + are, the harder they fall. In the same way, perhaps the only way to fight +a superior alien army is to allow it to invade your territory, learn its +weaponry and military secrets, and turn those very weapons and secrets +against it. + +So a superior alien army cannot be defeated head-on. But it will +withdraw if it cannot win and the cost of a stalemate is too high. Success +means depriving the enemy of a victory." +"But more than likely, I believe the aliens will be benevolent and, for +the most part, ignore us. We simply have nothing to offer them. If they +visit us, then it will be mainly out of curiosity or for reconnaissance. +(Since curiosity was an essential feature in our becoming intelligent, it is +likely that any alien species will be curious, and hence want to analyze +us, but not necessarily to make contact.) + +MEETING AN ALIEN ASTRONAUT + +Unlike in the movies, we will probably not meet the flesh-and-blood +alien creatures themselves. It would simply be too dangerous and + +unnecessary. In the same way that we sent the Mars Rover to explore, +aliens will more than likely send organic/mechanical surrogates or +avatars instead, which can better handle the stresses of interstellar +travel. In this way, the “aliens” we meet on the White House lawn may +look nothing like their masters back on the home planet. Instead, the +masters will project their consciousness into space through proxies." +"More than likely, though, they will send a robotic probe to our moon, +which is geologically stable, with no erosion. These probes are self- +replicating; that is, they will create a factory and manufacture, say, a +thousand copies of themselves. (These are called von Neumann probes, +after mathematician John von Neumann, who laid the foundation for +digital computers. Von Neumann was the first mathematician to +seriously consider the problem of machines that could reproduce +themselves.) These second-generation probes are then launched to other +star systems, where each one in turn creates a thousand more third- +generation probes, making a total of a million. Then these probes fan out +and create more factories, making a billion probes. Starting with just one +probe, we have one thousand, then a million, then a billion. Within five +generations, we have a quadrillion probes. Soon we have a gigantic +sphere, expanding at near light speed, containing trillions upon trillions" +"sphere, expanding at near light speed, containing trillions upon trillions +of probes, colonizing the entire galaxy within a few hundred thousand +years." +"Dr. Davies takes this idea of self-replicating von Neumann probes so +seriously that he has actually applied for funding to search the surface of +the moon for evidence of a previous alien visitation. He wishes to scan +the moon for radio emissions or radiation anomalies that would indicate +evidence of an alien visitation, perhaps millions of years ago. He wrote a +paper with Dr. Robert Wagner in the scientific journal Acta Astronautica +calling for a close examination of the photos from the Lunar +Reconnaissance Orbiter down to a resolution of about 1.5 feet." +"They wrote, “Although there is only a tiny probability that alien +technology would have left traces on the moon in the form of an artifact +or surface modification of lunar features, this location has the virtue of +being close,” and also traces of an alien technology would remain +preserved over long periods of time. Since there is no erosion on the +moon, treadmarks left by aliens would still be visible (in the same way +that footprints left by our astronauts in the 1970s could, in principle, last + +for billions of years). + +One problem is that the von Neumann probe might be very small. +Nanoprobes use molecular machines and MEMs, and hence it might be +only as big as a bread box, he said to me, or even smaller. (In fact, if +such a probe landed on Earth in someone’s backyard, the owner might +not even notice.)" +"This method, however, represents the most efficient way of colonizing +the galaxy, using the exponential growth of self-replicating von +Neumann probes. (This is also the way in which a virus infects our body. +Starting with a handful of viruses, they land on our cells, hijack the +reproductive machinery, and convert our cells into factories to create +more viruses. Within two weeks, a single virus can infect trillions of +cells, and we eventually sneeze.)" +"If this scenario is correct, it means that our own moon is the most +likely place for an alien visitation. This is also the basis of the movie +2001: A Space Odyssey, which even today represents the most plausible +encounter with an extraterrestrial civilization. In the movie, a probe was +placed on our moon millions of years ago, mainly to observe the +evolution of life on Earth. At times, it interferes in our evolution and +gives us an added boost. This information is then sent to Jupiter, which +is a relay station, before heading to the home planet of this ancient alien +civilization. + +From the point of view of this advanced civilization, which can +simultaneously scan billions of star systems, we can see that they have a +considerable choice in what planetary systems to colonize. Given the +sheer enormity of the galaxy, they can collect data and then best choose + + which planets or moons would yield the best resources. From their +perspective, they might not find Earth very appealing." +"The empires of the future will be empires of the mind. + +—WINSTON CHURCHILL + +If we continue to develop our technology without wisdom +prudence, our servant may prove to be our executioner. + +—GENERAL OMAR BRADLEY + +15 CONCLUDING REMARKS + +In 2000, a raging controversy erupted in the scientific community. +One of the founders of Sun Computers, Bill Joy, wrote an inflammatory +article denouncing the mortal threat we face from advanced technology. +In an article in Wired magazine with the provocative title “The Future +Does Not Need Us,” he wrote, “Our most powerful 21st century +technologies—robotics, genetic engineering, and nanotech—are +threatening to make humans an endangered species.” That incendiary +article questioned the very morality of hundreds of dedicated scientists +toiling in their labs on the cutting edge of science. He challenged the +very core of their research, stating that the benefits of these technologies +were vastly overshadowed by the enormous threats they posed to +humanity." +"He described a macabre dystopia in which all our technologies +conspire to destroy civilization. Three of our key creations will +eventually turn on us, he warned: + +• One day, bioengineered germs may escape from the laboratory and +wreak havoc on the world. Since you cannot recapture these life- +forms, they might proliferate wildly and unleash a fatal plague on +the planet worse than those of the Middle Ages. Biotechnology may +even alter human evolution, creating “several separate and unequal +species ... that would threaten the notion of equality that is the very +cornerstone of our democracy.” + +• One day, nanobots may go berserk and spew out unlimited +quantities of “gray goo,” which will blanket Earth, smothering all +life. Since these nanobots “digest” ordinary matter and create new +forms of matter, malfunctioning nanobots could run amok and" +"digest much of Earth. “Gray goo would surely be a depressing +ending to our human adventure on Earth, far worse than mere fire +or ice, and one that could stem from a simple laboratory accident. + +Oops,” he wrote. + +• One day, the robots will take over and replace humanity. They will +become so intelligent that they will simply push humanity aside. We +will be left as an evolutionary footnote. “The robots would in no +sense be our children.... On this path our humanity may well be +lost,” he wrote." +"Joy claimed that the dangers unleashed by these three technologies +dwarfed the dangers posed by the atomic bomb in the 1940s. Back then, +Einstein warned of the power of nuclear technology to destroy +civilization: “It has become appallingly obvious that our technology has +exceeded our humanity.” But the atomic bomb was built by a huge +government program that could be tightly regulated, while these +technologies are being developed by private companies that are lightly +regulated, if at all, Joy pointed out. + +Sure, he conceded, these technologies may alleviate some suffering in +the short term. But in the long term, the benefits are overwhelmed by +the fact that they may unleash a scientific Armageddon that may doom +the human race." +"Joy even accused scientists of being selfish and naive as they try to +create a better society. He wrote, “A traditional utopia is a good society +and a good life. A good life involves other people. This techno utopia is +all about ‘I don’t get diseases; I don’t die; I get to have better eyesight +and be smarter’ and all this. If you described this to Socrates or Plato, +they would laugh at you.” + +He concluded by stating, “I think it is no exaggeration to say we are +on the cusp of the further perfection of extreme evil, an evil whose +possibility spreads well beyond that which weapons of mass destruction +bequeathed to the nation-states....” + +The conclusion to all this? “Something like extinction,” he warned. + +As expected, the article sparked a firestorm of controversy." +"As expected, the article sparked a firestorm of controversy. + +That article was written over a decade ago. In terms of high +technology, that is a lifetime. It is now possible to view certain of its +predictions with some hindsight. Looking back at the article and putting +his warnings into perspective, we can easily see that Bill Joy exaggerated +many of the threats coming from these technologies, but he also spurred + + scientists to face up to the ethical, moral, and societal consequences of + +their work, which is always a good thing. + +And his article opened up a discussion about who we are. In +unraveling the molecular, genetic, and neural secrets of the brain, +haven’t we in some sense dehumanized humanity, reducing it to a +bucket of atoms and neurons? If we completely map every neuron of the +brain and trace every neural pathway, doesn’t that remove the mystery +and magic of who we are? + +A RESPONSE TO BILL JOY" +"A RESPONSE TO BILL JOY + +In retrospect, the threats from robotics and nanotechnology are more +distant than Bill Joy thought, and I would argue that with enough +warning, we can take a variety of countermeasures, such as banning +certain avenues of research if they lead to uncontrollable robots, placing +chips in them to shut them off if they become dangerous, and creating +fail-safe devices to immobilize all of them in an emergency. + +More immediate is the threat from biotechnology, where there is the +realistic danger of biogerms that might escape the laboratory. In fact, +Ray Kurzweil and Bill Joy jointly wrote an article criticizing the +publication of the complete genome of the 1918 Spanish flu virus, one of +the most lethal germs in modern history, which killed more people than +World War I. Scientists were able to reassemble the long-dead virus by +examining the corpses and blood of its victims and sequencing its genes, +and then they published it on the web." +"Safeguards already exist against the release of such a dangerous virus, +but steps must be taken to further strengthen them and add new layers +of security. In particular, if a new virus suddenly erupts in some distant +place on Earth, scientists must strengthen rapid-response teams that can +isolate the virus in the wild, sequence its genes, and then quickly +prepare a vaccine to prevent its spread. + +IMPLICATIONS FOR THE FUTURE OF THE MIND + +This debate also has a direct impact on the future of the mind. At +present, neuroscience is still rather primitive. Scientists can read and +videotape simple thoughts from the living brain, record a few memories, + + connect the brain to mechanical arms, enable locked-in patients to +control machines around them, silence specific regions of the brain via +magnetism, and identify the regions of the brain that malfunction in +mental illness." +"In the coming decades, however, the power of neuroscience may +become explosive. Current research is on the threshold of new scientific +discoveries that will likely leave us breathless. One day, we might +routinely control objects around us with the power of the mind, +download memories, cure mental illness, enhance our intelligence, +understand the brain neuron by neuron, create backup copies of the +brain, and communicate with one another telepathically. The world of +the future will be the world of the mind." +"Bill Joy did not dispute the potential of this technology to relieve +human suffering and pain. But what made him look on it with horror +was the prospect of enhanced individuals who might cause the human +species to split apart. In the article, he painted a dismal dystopia in +which only a tiny elite have their intelligence and mental processes +enhanced, while the masses of people live in ignorance and poverty. He +worried that the human race would fission in two, or perhaps cease to be +human at all. + +But as we have pointed out, almost all technologies when they are first +introduced are expensive and hence exclusively for the well-off. Because +of mass production, the falling cost of computers, competition, and +cheaper shipping, technologies inevitably filter down to the poor as well. +This was also the trajectory taken by phonographs, radio, TV, PCs, +laptops, and cell phones." +"Far from creating a world of haves and have-nots, science has been the +engine of prosperity. Of all the tools that humanity has harnessed since +the dawn of time, by far the most powerful and productive has been +science. The incredible wealth we see all around us is directly due to +science. To appreciate how technology reduces, rather than accentuates, +societal fault lines, consider the lives of our ancestors around 1900. Life +expectancy in the United States back then was forty-nine years. Many +children died in infancy. Communicating with a neighbor involved +yelling out the window. The mail was delivered by horse, if it came at +all. Medicine was largely snake oil. The only treatments that actually +worked were amputations (without anesthetics) and morphine to deaden + +the pain. Food rotted within days. Plumbing was nonexistent. Disease +was a constant threat. And the economy could support only a handful of +the rich and a tiny middle class." +"Technology has changed everything. We no longer have to hunt for +our food; we simply go to the supermarket. We no longer have to carry +back-breaking supplies but instead simply get into our cars. (In fact, the +main threat we face from technology, one that has killed millions of +people, is not murderous robots or mad nanobots run amok—it’s our +indulgent lifestyle, which has created near-epidemic levels of diabetes, +obesity, heart disease, cancer, etc. And this problem is self-inflicted.) + +We also see this on the global level. In the last few decades the world +has witnessed hundreds of millions of people being lifted out of grinding +poverty for the first time in history. If we view the bigger picture, we see +that a significant fraction of the human race has left the punishing +lifestyle of sustenance farming and entered the ranks of the middle class." +"It took several hundred years for Western nations to industrialize, yet +China and India are doing it within a few decades, all due to the spread +of high technology. With wireless technology and the Internet, these +nations can leapfrog past other, more developed nations that have +laboriously wired their cities. While the West struggles with an aging, +decaying urban infrastructure, developing nations are building entire +cities with sparkling, state-of-the-art technology." +"(When I was a graduate student getting my Ph.D., my counterparts in +China and India would have to wait several months to a year for +scientific journals to come in the mail. Plus, they had almost no direct +contact with scientists and engineers in the West, because few if any +could afford to travel here. This vastly impeded the flow of technology, +which moved at a glacial pace for these nations. Today, however, +scientists can read one another’s papers as soon as they are posted on the +Internet, and can electronically collaborate with other scientists around +the world. This has vastly accelerated the flow of information. And with +this technology comes progress and prosperity.)" +"Furthermore, it’s not clear that having some form of enhanced +intelligence will cause a catastrophic splitting of the human race, even if +many people are unable to afford this procedure. For the most part, +being able to solve complex mathematical equations or have perfect +recall does not guarantee a higher income, respect from your peers, or + +more popularity with the opposite sex, which are the incentives that +motivate most people. The Caveman Principle trumps having a brain +boost. + +As Dr. Michael Gazzaniga notes, “The idea that we are messin’ with +our innards is disturbing to many. And just what would we do with +expanded intelligence? Are we going to use it for solving problems, or +will it just allow us to have longer Christmas card lists ...?”" +"But as we discussed in Chapter 5, unemployed workers may benefit +from this technology, drastically reducing the time required to master +new technologies and skills. This might not only reduce the problems +associated with unemployment, it could also have an impact on the +world economy, making it more efficient and responsive to change. + +WISDOM AND DEMOCRATIC DEBATE + +In responding to Joy’s article, some critics pointed out that the debate is +not about a struggle between scientists and nature, as portrayed in the +article. The debate is actually between three parties: scientists, nature, +and society." +"Computer scientists Drs. John Brown and Paul Duguid responded to +the article by stating, “Technologies—such as gunpowder, the printing +press, the railroad, the telegraph, and the Internet—can change society +in profound ways. But on the other hand, social systems—in the form of +governments, the courts, formal and informal organizations, social +movements, professional networks, local communities, market +institutions, and so forth—shape, moderate, and redirect the raw power +of technologies.” + +The point is to analyze them in terms of society, and ultimately it is up +to us to adopt a new vision of the future that incorporates all the best +ideas. + +To me, the ultimate source of wisdom in this respect comes from +vigorous democratic debate. In the coming decades, the public will be +asked to vote on a number of crucial scientific issues. Technology cannot +be debated in a vacuum. + +PHILOSOPHICAL QUESTIONS" +"PHILOSOPHICAL QUESTIONS + +Lastly, some critics have claimed that the march of science has gone too +far in unveiling the secrets of the mind, an unveiling that has become +dehumanizing and degrading. Why bother to rejoice at discovering +something new, learning a new skill, or enjoying a leisurely vacation +when it can all be reduced to a few neurotransmitters activating a few +neural circuits? + +In other words, just as astronomy has reduced us to insignificant +pieces of cosmic dust floating in an uncaring universe, neuroscience has +reduced us to electrical signals circulating within neural circuits. But is +this really true?" +"We began our discussion by highlighting the two greatest mysteries in +all of science: the mind and the universe. Not only do they have a +common history and narrative, they also share a similar philosophy and +perhaps even destiny. Science, with all its power to peer into the heart of +black holes and land on distant planets, has given birth to two +overarching philosophies about the mind and the universe: the +Copernican Principle and the Anthropic Principle. Both are consistent +with everything known about science, but they are diametrical +opposites. + +The first great philosophy, the Copernican Principle, was born with +the discovery of the telescope more than four hundred years ago. It +states that there is no privileged position for humanity. Such a +deceptively simple idea has overthrown thousands of years of cherished +myths and entrenched philosophies." +"Ever since the biblical tale of Adam and Eve being exiled from the +Garden of Eden for biting into the Apple of Knowledge, there has been a +series of humiliating dethronements. First, the telescope of Galileo +clearly showed that Earth was not the center of the solar system—the +sun was. This picture was then overthrown when it was realized that the +solar system was just a speck in the Milky Way galaxy circulating about +thirty thousand light-years from the center. Then in the 1920s, Edwin +Hubble discovered there was a multitude of galaxies. The universe +suddenly got billions of times bigger. Now the Hubble Space Telescope +can reveal the presence of up to one hundred billion galaxies in the +visible universe. Our own Milky Way galaxy has been reduced to a +pinpoint in a much larger cosmic arena. + +More recent cosmological theories further downgrade the position of" +"More recent cosmological theories further downgrade the position of + +humanity in the universe. The inflationary universe theory states that +our visible universe, with its one hundred billion galaxies, is just a +pinprick on a much larger, inflated universe that is so big that most light +has not had time to reach us yet from distant regions. There are vast +reaches of space that we cannot see with our telescopes and will never +be able to visit because we cannot go faster than light. And if string +theory (my specialty) is correct, it means that even the entire universe +coexists with other universes in eleven-dimensional hyperspace. So even +three-dimensional space is not the final word. The true arena for +physical phenomena is the multiverse of universes, full of floating +bubble universes. + +The science-fiction writer Douglas Adams tried to summarize the sense +of being constantly overthrown by inventing the Total Perspective +Vortex in The Hitchhiker’s Guide to the Galaxy. It was designed to drive" +"any sane person insane. When you enter the chamber, all you see is a +gigantic map of the entire universe. And on the map there is a tiny, +almost invisible arrow that says, “You are here.” + +So on one hand, the Copernican Principle indicates that we are just +insignificant cosmic debris drifting aimlessly among the stars. But on the +other hand, all the latest cosmological data are consistent with yet +another theory, which gives us the opposite philosophy: the Anthropic +Principle. + +This theory states that the universe is compatible with life. Again, this +deceptively simple statement has profound implications. On one hand, it +is impossible to dispute that life exists in the universe. But it’s clear that +the forces of the universe must be calibrated to a remarkable degree to +make life possible. As physicist Freeman Dyson once said, “The universe +seemed to know that we were coming.”" +"For example, if the nuclear force were just a bit stronger, the sun +would have burned out billions of years ago, too soon to allow DNA to +get off the ground. If the nuclear force were a bit weaker, then the sun +would never have ignited to begin with, and we still would not be here. + +Likewise, if gravity were stronger, the universe would have collapsed +into a Big Crunch billions of years ago, and we would all be roasted to +death. If it were a bit weaker, then the universe would have expanded so +fast it would have reached the Big Freeze, so we would all have frozen to +death. + +This fine-tuning extends to every atom of the body. Physics says that +we are made of star dust, that the atoms we see all around us were +forged in the heat of a star. We are literally children of the stars." +"But the nuclear reactions that burned hydrogen to create the higher +elements of our body are very complex and could have been derailed at +any number of points. Then it would have been impossible to create the +higher elements of our bodies, and the atoms of DNA and life would not +exist. + +In other words, life is precious and a miracle. + +There are so many parameters that have to be fine-tuned that some +claim this is not a coincidence. The weak form of the Anthropic Principle +implies that the existence of life forces the physical parameters of the +universe to be defined in a very precise way. The strong form of the +Anthropic Principle goes even further, stating that God or some designer +had to create a universe “just right” to make life possible. + + PHILOSOPHY AND NEUROSCIENCE" +"PHILOSOPHY AND NEUROSCIENCE + +The debate between the Copernican Principle and the Anthropic +Principle also resonates in neuroscience. For example, some claim that +humans can be reduced to atoms, molecules, and neurons, and hence +there is no distinguished place for humanity in the universe. + +Dr. David Eagleman writes, “The you that all your friends know and +love cannot exist unless the transistors and screws of our brain are in +place. If you don’t believe this, step into any neurology ward in any +hospital. Damage to even small parts of the brain can lead to the loss of +shockingly specific abilities; the ability to name animals, or to hear +music, or to manage risky behavior, or to distinguish colors, or to +arbitrate simple decisions.” + +It seems that the brain cannot function without all its “transistors and +screws.” He concludes, “Our reality depends on what our biology is up +to.”" +"So on one hand, our place in the universe seems to be diminished if +we can be reduced, like robots, to (biological) nuts and bolts. We are just +wetware, running software called the mind, nothing more or less. Our +thoughts, desires, hopes, and aspirations can be reduced to electrical + +impulses circulating in some region of the prefrontal cortex. That is the +Copernican Principle applied to the mind. + +But the Anthropic Principle can also be applied to the mind, and we +then reach the opposite conclusion. It simply says that conditions of the +universe make consciousness possible, even though it is extraordinarily +difficult to create the mind out of random events. The great Victorian +biologist Thomas Huxley said, “How it is that anything so remarkable as +a state of consciousness comes about as a result of irritating nervous +tissue, is just as unaccountable as the appearance of the Djinn, when +Aladdin rubbed his lamp.”" +"Furthermore, most astronomers believe that although one day we may +find life on other planets, it will most likely be microbial life, which +ruled our oceans for billions of years. Instead of seeing great cities and +empires, we might only find oceans of drifting microorganisms. + +When I interviewed the late Harvard biologist Stephen Jay Gould +about this, he explained to me his thinking as follows. If we were to +somehow create a twin of Earth as it was 4.5 billion years ago, would it +turn out the same way 4.5 billion years later? Most likely not. There is a + + large probability that DNA and life would never have gotten off the +ground, and an even larger probability that intelligent life with +consciousness would never have risen from the swamp." +"Gould wrote, “Homo sapiens is one small twig [on the tree of life]. +... Yet our twig, for better or worse, has developed the most +extraordinary new quality in all the history of multicellular life since the +Cambrian explosion (500 million years ago). We have invented +consciousness with all its sequelae from Hamlet to Hiroshima.”" +"In fact, in the history of Earth, there are many times when intelligent +life was almost extinguished. In addition to the mass extinctions that +wiped out the dinosaurs and most life on Earth, humans have faced +additional near extinctions. For example, humans are all genetically +related to one another to a considerable degree, much closer than two +typical animals of the same species. Although humans may look diverse +from the outside, our genes and internal chemistry tell a different story. +In fact, any two humans are so closely related genetically that we can +actually do the math and calculate when a “genetic Eve” or “genetic +Adam” gave birth to the entire human race. Moreover, we can calculate +how many of us there were in the past." +"The numbers are remarkable. Genetics shows that there were only a +few hundred to a few thousand humans alive about seventy to one +hundred thousand years ago and that they gave birth to the entire +human race. (One theory holds that the titanic explosion of the Toba +volcano in Indonesia about seventy thousand years ago caused +temperatures to drop so dramatically that most of the human race +perished, leaving only a handful to populate Earth.) From that small +band of humans came the adventurers and explorers who would +eventually colonize the entire planet. + +Repeatedly in the history of Earth, intelligent life might have come to +a dead end. It is a miracle we survived. We can also conclude that +although life may exist on other planets, conscious life may exist on only +a tiny fraction of them. So we should treasure the consciousness that is +found on Earth. It is the highest form of complexity known in the +universe, and probably also the rarest." +"Sometimes, when contemplating the future destiny of the human race, +I have to come to grips with the distinct possibility of its self-destruction. +Although volcanic eruptions and earthquakes could spell doom for the +human race, our worst fears may be realized through man-made +disasters, such as nuclear wars or bioengineered germs. If so, then +perhaps the only conscious life-form in this sector of the Milky Way +galaxy might be extinguished. This, I feel, would be a tragedy not just +for us, but for the universe as well. We take for granted that we are + + conscious, but we don’t understand the long, tortuous sequence of +biological events that have transpired to make this possible. Psychologist +Steven Pinker writes, “I would argue that nothing gives life more +purpose than the realization that every moment of consciousness is a +precious and fragile gift.” + +THE MIRACLE OF CONSCIOUSNESS" +"THE MIRACLE OF CONSCIOUSNESS + +Lastly, there is the criticism of science that says to understand something +is to remove its mystery and magic. Science, by lifting the veil +concealing the secrets of the mind, is also making it more ordinary and +mundane. However, the more I learn about the sheer complexity of the +brain, the more amazed I am that something that sits on our shoulders is + +the most sophisticated object we know about in the universe. As Dr. +David Eagleman says, “What a perplexing masterpiece the brain is, and +how lucky we are to be in a generation that has the technology and the +will to turn our attention to it. It is the most wondrous thing we have +discovered in the universe, and it is us.” Instead of diminishing the sense +of wonder, learning about the brain only increases it. + +More than two thousand years ago, Socrates said, “To know thyself is +the beginning of wisdom.” We are on a long journey to complete his +wishes. + +APPENDIX + +QUANTUM CONSCIOUSNESS?" +"APPENDIX + +QUANTUM CONSCIOUSNESS? + +In spite of all the miraculous advances in brain scans and high +technology, some people claim that we will never understand the secret +of consciousness, since consciousness is beyond our puny technology. In +fact, in their view consciousness is more fundamental than atoms, +molecules, and neurons and determines the nature of reality itself. To +them, consciousness is the fundamental entity out of which the material +world is created. And to prove their point, they refer to one of the +greatest paradoxes in all of science, which challenges our very definition +of reality: the Schrodinger’s Cat paradox. Even today, there is no +universal consensus on the question, with Nobel laureates taking +divergent stances. What is at stake is nothing less than the nature of +reality and thought." +"The Schrodinger’s Cat paradox cuts to the very foundation of quantum +mechanics, a field that makes lasers, MRI scans, radio and TV, modern +electronics, the GPS, and telecommunications possible, upon which the +world economy depends. Many of quantum theory’s predictions have +been tested to an accuracy of one part in one hundred billion. + +I have spent my entire professional career working on the quantum +theory. Yet I realize that it has feet of clay. It’s an unsettling feeling +knowing my life’s work is based on a theory whose very foundation is +based on a paradox." +"This debate was sparked by Austrian physicist Erwin Schrodinger, who +was one of the founding fathers of the quantum theory. He was trying to +explain the strange behavior of electrons, which seemed to exhibit both +wave and particle properties. How can an electron, a point particle, have +two divergent behaviors? Sometimes electrons acted like a particle, +creating well-defined tracks in a cloud chamber. Other times, electrons +acted like a wave, passing through tiny holes and creating wavelike +interference patterns, like those on the surface of a pond. + +In 1925, Schrodinger put forward his celebrated wave equation, which" +"In 1925, Schrodinger put forward his celebrated wave equation, which + +bears his name and is one of the most important equations ever written. +It was an instant sensation, and won him the Nobel Prize in 1933. The +Schrodinger equation accurately described the wavelike behavior of +electrons and, when applied to the hydrogen atom, explained its strange +properties. Miraculously, it could also be applied to any atom and +explain most of the features of the periodic table of elements. It seemed +as if all chemistry (and hence all biology) were nothing but solutions of +this wave equation. Some physicists even claimed that the entire +universe, including all the stars, planets, and even us, was nothing but a +solution of this equation. + +But then physicists began to ask a problematic question that resonates +even today: If the electron is described by a wave equation, then what is +waving?" +"In 1927, Werner Heisenberg proposed a new principle that split the +physics community down the middle. Heisenberg’s celebrated +uncertainty principle states that you cannot know both the location and +the momentum of an electron with certainty. This uncertainty was not a +function of how crude your instruments were but was inherent in +physics itself. Even God or some celestial being could not know the +precise location and momentum of an electron. + +So the wave function of Schrodinger actually described the probability +of finding the electron. Scientists had spent thousands of years painfully + + trying to eliminate chance and probabilities in their work, and now +Heisenberg was allowing it in through the back door. + +The new philosophy can be summed up as follows: the electron is a +point particle, but the probability of finding it is given by a wave. And +this wave obeys Schrodinger’s equation and gives rise to the uncertainty +principle." +"The physics community cracked in half. On one side, we had +physicists like Niels Bohr, Werner Heisenberg, and most atomic +physicists eagerly adopting this new formulation. Almost daily, they +were announcing new breakthroughs in understanding the properties of +matter. Nobel Prizes were being handed out to quantum physicists like +Oscars. Quantum mechanics was becoming a cookbook. You did not +need to be a master physicist to make stellar contributions—you just +followed the recipes given by quantum mechanics and you would make +stunning breakthroughs. + +On the other side, we had aging Nobel laureates like Albert Einstein, +Erwin Schrodinger, and Louis de Broglie who were raising philosophical +objections. Schrodinger, whose work helped start this whole process, +grumbled that if he had known that his equation would introduce +probability into physics, he would never have created it in the first +place." +"Physicists embarked on an eighty-year debate that continues even +today. On one hand, Einstein would proclaim that “God does not play +dice with the world.” Niels Bohr, on the other hand, reportedly replied, +“Stop telling God what to do.” + +In 1935, to demolish the quantum physicists once and for all, +Schrodinger proposed his celebrated cat problem. Place a cat in a sealed +box, with a container of poison gas. In the box, there is a lump of +uranium. The uranium atom is unstable and emits particles that can be +detected by a Geiger counter. The counter triggers a hammer, which falls +and breaks the glass, releasing the gas, which can kill the cat." +"How do you describe the cat? A quantum physicist would say that the +uranium atom is described by a wave, which can either decay or not +decay. Therefore you have to add the two waves together. If the uranium +fires, then the cat dies, so that is described by one wave. If the uranium +does not fire, then the cat lives, and that is also described by a wave. To +describe the cat, you therefore have to add the wave of a dead cat to the +wave of a live cat. + +This means that the cat is neither dead nor alive! The cat is in a +netherworld, between life and death, the sum of the wave describing a + + dead cat with the wave of a live cat. + +This is the crux of the problem, which has reverberated in the halls of +physics for almost a century. So how do you resolve this paradox? There +are at least three ways (and hundreds of variations on these three)." +"The first is the original Copenhagen interpretation proposed by Bohr +and Heisenberg, the one that is quoted in textbooks around the world. (It +is the one that I start with when I teach quantum mechanics.) It says that +to determine the state of the cat, you must open the box and make a +measurement. The cat’s wave (which was the sum of a dead cat and a +live cat) now “collapses” into a single wave, so the cat is now known to +be alive (or dead). Thus, observation determines the existence and state +of the cat. The measurement process is thus responsible for two waves + +magically dissolving into a single wave." +"magically dissolving into a single wave. + +Einstein hated this. For centuries, scientists have battled something +called “solipsism” or “subjective idealism,” which claims that objects +cannot exist unless there is someone there to observe them. Only the +mind is real—the material world exists only as ideas in the mind. Thus, +say the solipsists (such as Bishop George Berkeley), if a tree falls in the +forest but no one is there to observe it, perhaps the tree never fell. +Einstein, who thought all this was pure nonsense, promoted an opposing +theory called “objective reality,” which says simply that the universe +exists in a unique, definite state independent of any human observation. +It is the commonsense view of most people." +"Objective reality goes back to Isaac Newton. In this scenario, the atom +and subatomic particles are like tiny steel balls, which exist at definite +points in space and time. There is no ambiguity or chance in locating the +position of these balls, whose motions can be determined by using the +laws of motion. Objective reality was spectacularly successful in +describing the motions of planets, stars, and galaxies. Using relativity, +this idea can also describe black holes and the expanding universe. But +there is one place where it fails miserably, and that is inside the atom. + +Classical physicists like Newton and Einstein thought that objective +reality finally banished solipsism from physics. Walter Lippmann, the +columnist, summed it up when he wrote, “The radical novelty of modern +science lies precisely in the rejection of the belief ... that the forces +which move the stars and atoms are contingent upon the preferences of +the human heart.”" +"But quantum mechanics allowed a new form of solipsism back into +physics. In this picture, before it is observed, a tree can exist in any +possible state (e.g., sapling, burned, sawdust, toothpicks, decayed). But + + when you look at it, the wave suddenly collapses and it looks like a tree. +The original solipsists talked about trees that either fell or didn’t. The +new quantum solipsists were introducing all possible states of a tree. + +This was too much for Einstein. He would ask guests at his house, +“Does the moon exist because a mouse looks at it?” To a quantum +physicist, in some sense the answer might be yes. + +Einstein and his colleagues would challenge Bohr by asking: How can +the quantum microworld (with cats being dead and alive +simultaneously) coexist with the commonsense world we see around us?" +"The answer was that there is a “wall” that separates our world from the +atomic world. On one side of the wall, common sense rules. On the other +side of the wall, the quantum theory rules. You can move the wall if you +want and the results are still the same. + +This interpretation, no matter how strange, has been taught for eighty +years by quantum physicists. More recently, there have been some +doubts cast on the Copenhagen interpretation. Today we have +nanotechnology, with which we can manipulate individual atoms at will. +On a scanning tunneling microscope screen, atoms appear to be fuzzy +tennis balls. (For BBC-TV, I had a chance to fly out to IBM’s Almaden +Lab in San Jose, California, and actually push individual atoms around +with a tiny probe. It is now possible to play with atoms, which were +once thought to be so small they could never be seen.)" +"As we’ve discussed, the Age of Silicon is slowly coming to an end, and +some believe that molecular transistors will replace silicon transistors. If +so, then the paradoxes of the quantum theory may lie at the very heart +of every computer of the future. The world economy may eventually rest +on these paradoxes. + +COSMIC CONSCIOUSNESS AND MULTIPLE UNIVERSES + +There are two alternate interpretations of the cat paradox, which take us +to the strangest realms in all science: the realm of God and multiple +universes. + +In 1967, the second resolution to the cat problem was formulated by +Nobel laureate Eugene Wigner, whose work was pivotal in laying the +foundation of quantum mechanics and also building the atomic bomb. +He said that only a conscious person can make an observation that +collapses the wave function. But who is to say that this person exists? +You cannot separate the observer from the observed, so maybe this" +"person is also dead and alive. In other words, there has to be a new +wave function that includes both the cat and the observer. To make sure +that the observer is alive, you need a second observer to watch the first +observer. This second observer is called “Wigner’s friend,” and is +necessary to watch the first observer so that all waves collapse. But how +do we know that the second observer is alive? The second observer has + +to be included in a still-larger wave function to make sure he is alive, +but this can be continued indefinitely. Since you need an infinite number +of “friends” to collapse the previous wave function to make sure they are +alive, you need some form of “cosmic consciousness,” or God. + +Wigner concluded: “It was not possible to formulate the laws (of +quantum theory) in a fully consistent way without reference to +consciousness.” Toward the end of his life, he even became interested in +the Vedanta philosophy of Hinduism." +"In this approach, God or some eternal consciousness watches over all +of us, collapsing our wave functions so that we can say we are alive. This +interpretation yields the same physical results as the Copenhagen +interpretation, so this theory cannot be disproven. But the implication is +that consciousness is the fundamental entity in the universe, more +fundamental than atoms. The material world may come and go, but +consciousness remains as the defining element, which means that +consciousness, in some sense, creates reality. The very existence of the +atoms we see around us is based on our ability to see and touch them." +"(At this point, it’s important to note that some people think that +because consciousness determines existence, then consciousness can +therefore control existence, perhaps by meditation. They think that we +can create reality according to our wishes. This thinking, as attractive as +it might sound, goes against quantum mechanics. In quantum physics, +consciousness makes observations and therefore determines the state of +reality, but consciousness cannot choose ahead of time which state of +reality actually exists. Quantum mechanics allows you only to determine +the chance of finding one state, but we cannot bend reality to our +wishes. For example, in gambling, it is possible to mathematically +calculate the chances of getting a royal flush. However, this does not +mean that you can somehow control the cards to get the royal flush. You +cannot pick and choose universes, just as we have no control over +whether the cat is dead or alive.) + +MULTIPLE UNIVERSES" +"MULTIPLE UNIVERSES + +The third way to resolve the paradox is the Everett, or many-worlds, + + interpretation, which was proposed in 1957 by Hugh Everett. It is the + +strangest theory of all. It says that the universe is constantly splitting +apart into a multiverse of universes. In one universe, we have a dead cat. +In another universe, we have a live cat. This approach can be +summarized as follows: wave functions never collapse, they just split. +The Everett many-worlds theory differs from the Copenhagen +interpretation only in that it drops the final assumption: the collapse of +the wave function. In some sense, it is the simplest formulation of +quantum mechanics, but also the most disturbing. + +There are profound consequences to this third approach. It means that +all possible universes might exist, even ones that are bizarre and +seemingly impossible. (However, the more bizarre the universe, the +more unlikely it is.)" +"This means people who have died in our universe are still alive in +another universe. And these dead people insist that their universe is the +correct one, and that our universe (in which they are dead) is fake. But if +these “ghosts” of dead people are still alive somewhere, then why can’t +we meet them? Why can’t we touch these parallel worlds? (As strange as +it may seem, in this picture Elvis is still alive in one of these universes.)" +"What’s more, some of these universes may be dead, without any life, +but others may look exactly like ours, except for one key difference. For +example, the collision of a single cosmic ray is a tiny quantum event. But +what happens if this cosmic ray goes through Adolf Hitler’s mother, and +the infant Hitler dies in a miscarriage? Then a tiny quantum event, the +collision of a single cosmic ray, causes the universe to split in half. In +one universe, World War II never happened, and sixty million people did +not have to die. In the other universe, we’ve had the ravages of World +War II. These two universes grow to be quite far apart, yet they are +initially separated by one tiny quantum event." +"This phenomenon was explored by science-fiction writer Philip K. Dick +in his novel The Man in the High Tower, where a parallel universe opens +up because of a single event: a bullet is fired at Franklin Roosevelt, who +is killed by an assassin. This pivotal event means that the United States +is not prepared for World War II, and the Nazis and Japanese are +victorious and eventually partition the United States in half. + +But whether the bullet fires or misfires depends, in turn, on whether a +microscopic spark is set off in the gunpowder, which itself depends on +complex molecular reactions involving the motions of electrons. So + + perhaps quantum fluctuations in the gunpowder may determine whether +the gun fires or misfires, which in turn determines whether the Allies or +the Nazis emerge victorious during World War II." +"So there is no “wall” separating the quantum world and the +macroworld. The bizarre features of the quantum theory can creep into +our “commonsense” world. These wave functions never collapse—they +keep splitting endlessly into parallel realities. The creation of alternative +universes never stops. The paradoxes of the microworld (i.e., being dead +and alive simultaneously, being in two places at the same time, +disappearing and reappearing somewhere else) now enter into our world +as well. + +But if the wave function is continually splitting apart, creating entirely +new universes in the process, then why can’t we visit them?" +"Nobel laureate Steven Weinberg compares this to listening to the radio +in your living room. There are hundreds of radio waves simultaneously +filling up your room from all over the world, but your radio dial is tuned +to only one frequency. In other words, your radio has “decohered” from +all the other stations. (Coherence is when all waves vibrate in perfect +unison, as in a laser beam. Decoherence is when these waves begin to +fall out of phase, so they no longer vibrate in unison.) These other +frequencies all exist, but your radio cannot pick them up because they +are not vibrating at the same frequency that we are anymore. They have +decoupled; that is, they have decohered from us." +"In the same way, the wave function of the dead and alive cat have +decohered as time goes on. The implications are rather staggering. In +your living room, you coexist with the waves of dinosaurs, pirates, aliens +from space, and monsters. Yet you are blissfully unaware that you are +sharing the same space as these strange denizens of quantum space, +because your atoms are no longer vibrating in unison with them. These +parallel universes do not exist in some distant never-never land. They +exist in your living room. + +Entering one of these parallel worlds is called “quantum jumping” or +“sliding” and is a favorite gimmick of science fiction. To enter a parallel +universe, we need to take a quantum jump into it. (There was even a TV +series called Sliders where people slide back and forth between parallel +universes. The series began when a young boy read a book. That book is +actually my book Hyperspace, but I take no responsibility for the physics + +behind that series.)" +"behind that series.) + +Actually, it’s not so simple to jump between universes. One problem +we sometimes give our Ph.D. students is to calculate the probability that + + you will jump through a brick wall and wind up on the other side. The +result is sobering. You would have to wait longer than the lifetime of the +universe to experience jumping or sliding through a brick wall. + +LOOKING IN THE MIRROR" +"LOOKING IN THE MIRROR + +When I look at myself in a mirror, I don’t really see myself as I truly am. +First, I see myself about a billionth of a second ago, since that is the time +that it takes a light beam to leave my face, hit a mirror, and enter my +eyes. Second, the image I see is really an average over billions and +billions of wave functions. This average certainly does resemble my +image, but it is not exact. Surrounding me are multiple images of myself +oozing in all directions. I am continually surrounded by alternate +universes, forever branching into different worlds, but the probability of +sliding between them is so tiny that Newtonian mechanics seems to be +correct." +"At this point, some people ask this question: Why don’t scientists +simply do an experiment to determine which interpretation is valid? If +we run an experiment with an electron, all three interpretations will +yield the same result. All three are therefore serious, viable +interpretations of quantum mechanics, with the same underlying +quantum theory. What is different is how we explain the results. + +Hundreds of years in the future, physicists and philosophers may still +be debating this question, with no resolution, because all three +interpretations yield the same physical results. But perhaps there is one +way in which this philosophical debate touches on the brain, and that is +the question of free will, which in turn affects the moral foundation of +human society. + +FREE W ILT. + +Our entire civilization is based on the concept of free will, which +impacts on the notions of reward, punishment, and personal" +"responsibility. But does free will really exist? Or is it a clever way of +keeping society together although it violates scientific principles? The +controversy goes to the very heart of quantum mechanics itself. + +It is safe to say that more and more neuroscientists are gradually +coming to the conclusion that free will does not exist, at least not in the +usual sense. If certain bizarre behaviors can be linked to precise defects + + in the brain, then a person is not scientifically responsible for the crimes +he might commit. He might be too dangerous to be left walking the +streets and must be locked up in an institution of some sort, but +punishing someone for having a stroke or tumor in the brain is +misguided, they say. What that person needs is medical and +psychological help. Perhaps the brain damage can be treated (e.g., by +removing a tumor), and the person can become a productive member of +society." +"For example, when I interviewed Dr. Simon Baron-Cohen, a +psychologist at Cambridge University, he told me that many (but not all) +pathological killers have a brain anomaly. Their brain scans show that +they lack empathy when seeing someone else in pain, and in fact they +might even take pleasure in watching this suffering (in these individuals, +the amygdala and the nucleus accumbens, the pleasure center, light up +when they view videos of people experiencing pain). + +The conclusion some might draw from this is that these people are not +truly responsible for their heinous acts, although they should still be +removed from society. They need help, not punishment, because of a +problem with their brain. In a sense, they may not be acting with free +will when they commit their crimes." +"An experiment done by Dr. Benjamin Libet in 1985 casts doubt on the +very existence of free will. Let’s say that you are asking subjects to watch +a clock and then to note precisely when they decide to move a finger. +Using EEG scans, one can detect exactly when the brain makes this +decision. When you compare the two times, you will find a mismatch. +The EEG scans show that the brain has actually made the decision about +three hundred milliseconds before the person becomes aware of it. + +This means that, in some sense, free will is a fake. Decisions are made +ahead of time by the brain, without the input of consciousness, and then +later the brain tries to cover this up (as it’s wont to do) by claiming that +the decision was conscious. Dr. Michael Sweeney concludes, “Libet’s + +findings suggested that the brain knows what a person will decide before +the person does.... The world must reassess not only the idea of +movements divided between voluntary and involuntary, but also the +very idea of free will.”" +"All this seems to indicate that free will, the cornerstone of society, is a +fiction, an illusion created by our left brain. So are we masters of our +fate, or just pawns in a swindle perpetuated by the brain? + +There are several ways to approach this sticky question. Free will goes +against a philosophy called determinism, which simply says that all + + future events are determined by physical laws. According to Newton +himself, the universe was some sort of clock, ticking away since the +beginning of time, obeying the laws of motion. Hence all events are +predictable. + +The question is: Are we part of this clock? Are all our actions also +determined? These questions have philosophical and theological +implications. For example, most religions adhere to some form of +determinism and predestination. Since God is omnipotent, omniscient, +and omnipresent, He knows the future, and hence the future is +determined ahead of time. He knows even before you are born whether +you will go to Heaven or Hell." +"The Catholic Church split in half on this precise question during the +Protestant revolution. According to Catholic doctrine at that time, one +could change one’s ultimate fate with an indulgence, usually by making +generous financial donations to the Church. In other words, determinism +could be altered by the size of your wallet. Martin Luther specifically +singled out the corruption of the Church over indulgences when he +tacked his 95 Theses on the door of a church in 1517, triggering the +Protestant Reformation. This was one of the key reasons why the Church +split down the middle, causing casualties in the millions and laying +waste to entire regions of Europe." +"But after 1925, uncertainty was introduced into physics via quantum +mechanics. Suddenly everything became uncertain; all you could +calculate was probabilities. In this sense, perhaps free will does exist, +and it’s a manifestation of quantum mechanics. So some claim that the +quantum theory reestablishes the concept of free will. The determinists +have fought back, however, claiming that quantum effects are extremely +small (at the level of atoms), too small to account for the free will of + +large human beings. + +The situation today is actually rather muddled. Perhaps the question +“Does free will exist?” is like the question “What is life?” The discovery +of DNA has rendered that question about life obsolete. We now realize +that the question has many layers and complexities. Perhaps the same +applies to free will, and there are many types." +"If so, the very definition of “free will” becomes ambiguous. For +example, one way to define free will is to ask whether behavior can be +predicted. If free will exists, then behavior cannot be determined ahead +of time. Let’s say you watch a movie, for example. The plot is completely +determined, with no free will whatsoever. So the movie is completely +predictable. But our world cannot be like a movie, for two reasons. The +first is the quantum theory, as we have seen. The movie represents only + + one possible timeline. The second reason is chaos theory. Although +classical physics says that all of the motions of atoms are completely +determined and predictable, in practice it is impossible to predict their +motions because there are so many atoms involved. The slightest +disturbance of a single atom can have a ripple effect, which can cascade +down to create enormous disturbances." +"Think of the weather. In principle, if you knew the behavior of every +atom in the air, you could predict the weather a century from now if you +had a big enough computer. But in practice, this is impossible. After just +a few hours, the weather becomes so turbulent and complex that any +computer simulation is rendered useless. + +This creates what is called the “butterfly effect,” which means that +even the beat of butterfly wings can cause tiny ripples in the +atmosphere, which grow and in turn can escalate into a thunderstorm. +So if even the flapping of butterfly wings can create thunderstorms, the +hope of accurately predicting the weather is far-fetched. + +Let’s go back to the thought experiment described to me by Stephen +Jay Gould. He asked me to imagine Earth 4.5 billion years ago, when it +was born. Now imagine you could somehow create an identical copy of +Earth, and let it evolve. Would we still be here on this different Earth 4.5 +billion years later?" +"One could easily imagine, due to quantum effects or the chaotic nature +of the weather and oceans, that humanity would never evolve into +precisely the same creatures on this version of Earth. So ultimately, it + +seems a combination of uncertainty and chaos makes a perfectly +deterministic world impossible. + +THE QUANTUM BRAIN + +This debate also affects the reverse engineering of the brain. If you can +successfully reverse engineer a brain made of transistors, this success +implies that the brain is deterministic and predictable. Ask it any +question and it repeats the exact same answer. Computers are +deterministic in this way, since they always give the same answer for +any question. + +So it seems we have a problem. On one hand, quantum mechanics and +chaos theory claim that the universe is not predictable, and therefore, +free will seems to exist. But a reverse-engineered brain, made of +transistors, would by definition be predictable. Since the reverse-" +"engineered brain is theoretically identical to a living brain, then the +human brain is also deterministic and there is no free will. Clearly, this +contradicts the first statement." +"A minority of scientists claim that you cannot authentically reverse +engineer the brain, or ever create a true thinking machine, because of +the quantum theory. The brain, they argue, is a quantum device, not just +a collection of transistors. Hence this project is doomed to fail. In this +camp is Oxford physicist Dr. Roger Penrose, an authority on Einstein’s +theory of relativity, who claims that it is quantum processes that may +account for the consciousness of the human brain. Penrose starts by +saying that mathematician Kurt Godel has proven that arithmetic is +incomplete; that is, that there are true statements in arithmetic that +cannot be proven using the axioms of arithmetic. Similarly, not only is +mathematics incomplete, but so is physics. He concludes by stating that +the brain is basically a quantum mechanical device and there are +problems that no machine can solve because of Godel’s incompleteness +theorem. Humans, however, can make sense of these conundrums using +intuition." +"Similarly, the reverse-engineered brain, no matter how complex, is +still a collection of transistors and wires. In such a deterministic system, +you can accurately predict its future behavior because the laws of + +motion are well known. In a quantum system, however, the system is +inherently unpredictable. All you can calculate are the chances that +something will occur, because of the uncertainty principle. + +If it turns out that the reverse-engineered brain cannot reproduce +human behavior, then scientists may be forced to admit that there are +unpredictable forces at work (i.e., quantum effects inside the brain). Dr. +Penrose argues that inside the neuron there are tiny structures, called +microtubules, where quantum processes dominate." +"At present, there is no consensus on this problem. Judging from the +reaction to Penrose’s idea when it was first proposed, it would be safe to +say that most of the scientific community is skeptical of his approach. +Science, however, is never conducted as a popularity contest, but instead +advances through testable, reproducible, and falsifiable theories. + +For my own part, I believe transistors cannot truly model all the +behaviors of neurons, which carry out both analog and digital +calculations. We know that neurons are messy. They can leak, misfire, +age, die, and are sensitive to the environment. To me, this suggests that +a collection of transistors can only approximately model the behavior of +neurons. For example, we saw earlier, in discussing the physics of the +brain, that if the axon of the neuron becomes thinner, then it begins to" +"leak and also does not carry out chemical reactions that well. Some of +this leakage and these misfires will be due to quantum effects. As you try +to imagine neurons that are thinner, denser, and faster, quantum effects +become more obvious. This means that even for normal neurons there +are problems of leakage and instabilities, and these problems exist both +classically and quantum mechanically. + +In conclusion, a reverse-engineered robot will give a good but not +perfect approximation of the human brain. Unlike Penrose, I think it is +possible to create a deterministic robot out of transistors that gives the +appearance of consciousness, but without any free will. It will pass the +Turing test. But I think there will be differences between such a robot +and humans due to these tiny quantum effects." +"Ultimately, I think free will probably does exist, but it is not the free +will envisioned by rugged individualists who claim they are complete +masters of their fate. The brain is influenced by thousands of +unconscious factors that predispose us to make certain choices ahead of +time, even if we think we made them ourselves. This does not + +necessarily mean that we are actors in a film that can be rewound +anytime. The end of the movie hasn’t been written yet, so strict +determinism is destroyed by a subtle combination of quantum effects +and chaos theory. In the end, we are still masters of our destiny. + +NOTES + +INTRODUCTION" +"NOTES + +INTRODUCTION + +1 You may have to travel: To see this, define “complex” in terms of the +total amount of information that can be stored. The closest rival to the +brain might be the information contained within our DNA. There are +three billion base pairs in our DNA, each one containing one of four +nucleic acids, labeled A,T,C,G. Therefore the total amount of +information we can store in our DNA is four raised to the three- +billionth power. But the brain can store much more information +among its one hundred billion neurons, which can either fire or not +fire. Hence, there are two raised to the one-hundred-billionth power +possible initial states of the human brain. But while DNA is static, the +states of the brain change every few milliseconds. A simple thought +may contain one hundred generations of neural firings. Hence, there +are two raised to one hundred billion, all raised to the hundredth +power, possible thoughts contained in one hundred generations. But" +"our brains are continually firing, day and night, ceaselessly +computing. Therefore the total number of thoughts possible within N +generations is two raised to the one-hundred-billionth power, all +raised to the Nth power, which is truly astronomical. Therefore the +amount of information that we can store in our brains far exceeds the +information stored within our DNA by a wide margin. In fact, it is the +largest amount of information that we can store in our solar system, +and even possibly in our sector of the Milky Way galaxy. + +2 “The most valuable insights”: Boleyn-Fitzgerald, p. 89. + +3 “All of these questions that philosophers”: Boleyn-Fitzgerald, p. +137. + +CHAPTER 1: UNLOCKING THE MIND + +1 He was semiconscious for weeks: See Sweeney, pp. 207-8. + +2 Dr. John Harlow, the doctor who treated: Carter, p. 24. + +3 In the year A.D. 43, records show: Horstman, p. 87. + +4 “It was like ... standing in the doorway”: Carter, p. 28. + +5 The Transparent Brain: New York Times, April 10, 2013, p. 1." +"5 The Transparent Brain: New York Times, April 10, 2013, p. 1. + +6 “Emotions are not feelings at all”: Carter, p. 83. + +7 the mind is more like a “society of minds”: Interview with Dr. +Minsky for the BBC-TV series Visions of the Future, February 2007. +Also, interview for Science Fantastic national radio broadcast, +November 2009. + +8 consciousness was like a storm raging: Interview with Dr. Pinker in +September 2003 for Exploration national radio broadcast. + +9 “the intuitive feeling we have”: Pinker, “The Riddle of Knowing +You’re Here,” in Your Brain: A User’s Guide (New York: Time Inc. +Specials, 2011). + +10 Consciousness turns out to consist of: Boleyn-Fitzgerald, p. 111. + +11 “indeed a conscious system in its own right”: Carter, p. 52. + +12 I asked him how experiments: Interview with Dr. Michael +Gazzaniga in September 2012 for Science Fantastic national radio +broadcast. + + 13 “The possible implications of this”: Carter, p. 53. + +14 “If that person dies, what happens?”: Boleyn-Fitzgerald, p. 119." +"14 “If that person dies, what happens?”: Boleyn-Fitzgerald, p. 119. + +15 a young king who inherits: Interview with Dr. David Eagleman in +May 2012 for Science Fantastic national radio broadcast. + +16 “people named Denise or Dennis”: Eagleman, p. 63. + +17 “at least 15 % of human females”: Eagleman, p. 43. + +CHAPTER 2: CONSCIOUSNESS—A PHYSICIST’S VIEWPOINT + +1 “We cannot see ultraviolet light”: Pinker, How the Mind Works, pp. +561-65. + +2 “Everybody knows what consciousness is”: Biological Bulletin 215, +no. 3 (December 2008): 216." +"2 “Everybody knows what consciousness is”: Biological Bulletin 215, +no. 3 (December 2008): 216. + +3 We will do so in the notes: Level II consciousness can be counted by +listing the total number of distinct feedback loops when an animal +interacts with members of its species. As a rough guess, Level II +consciousness can be approximated by multiplying the number of +others in an animal’s pack or tribe, multiplied by the total number of +distinct emotions or gestures it uses to communicate with others. +There are caveats to this ranking, however, since this is just a first +guess. + +For example, animals like the wildcat are social, but they are also +solitary hunters, so it appears as if the number of animals in its pack is +one. But that is true only when it is hunting. When it is time to +reproduce, wildcats engage in complex mating rituals, so its Level II +consciousness must take this into account." +"Furthermore, when female wildcats give birth to litters of kittens, +which have to be nursed and fed, the number of social interactions +increases as a consequence. So even for solitary hunters, the number +of members of its species that it interacts with is not one, and the total +number of distinct feedback loops can be quite large. + +Also, if the number of wolves in the pack decreases, then it appears +as if its Level II number decreases correspondingly. To account for +this, we have to introduce the concept of an average Level II number +that is common for the entire species, as well as a specific Level II +consciousness for an individual animal. + + The average Level II number for a given species does not change if +the pack gets smaller, because it is common for the entire species, but +the individual Level II number (because it measures individual mental +activity and consciousness) does change." +"When applied to humans, the average Level II number must take +into account the Dunbar number, which is 150, and represents roughly + +the number of people in our social grouping that we can keep track of. +So the Level II number for humans as a species would be the total +number of distinct emotions and gestures we use to communicate, +multiplied by the Dunbar number of 150. (Individuals can have +different levels of Level II consciousness, since their circle of friends +and the ways they interact with them can vary considerably.) + +We should also note that certain Level I organisms (like insects and +reptiles) can exhibit social behaviors. Ants, when they bump into one +another, exchange information via chemical scents, and bees dance to +communicate the location of flower beds. Reptiles even have a +primitive limbic system. But in the main, they do not exhibit +emotions. + +4 “The difference between man”: Gazzaniga, p. 27. + +5 “The greatest achievement of the human brain”: Gilbert, p. 5." +"5 “The greatest achievement of the human brain”: Gilbert, p. 5. + +6 “area 10 (the internal granular layer IV)”: Gazzaniga, p. 20. + +7 The male gets confused, because it wants: Eagleman, p. 144. + +8 “I predict that mirror neurons”: Brockman, p. xiii. + +9 Biologist Carl Zimmer writes: Bloom, p. 51. + +10 “Most of the time we daydream”: Bloom, p. 51. + +Ill asked one person who may: Interview with Dr. Michael Gazzaniga +in September 2012 for Science Fantastic national radio broadcast. + +12 “It is the left hemisphere”: Gazzaniga, p. 85. + +CHAPTER 3: TELEPATHY—A PENNY FOR YOUR THOUGHTS + +1 Indeed, in a recent “Next 5 in 5”: http://www.ibm.com/5in5. + +2 I had the pleasure of touring: Interview with Dr. Gallant on July 11, + + 2012, at the University of California, Berkeley. Also, interview with +Dr. Gallant on Science Fantastic for national radio, July 2012. + +3 “This is a major leap forward”: Berkeleyan Newsletter, September +22, 2011, http://newscenter.berkeley.edu/2011/09/22/brain-movies." +"4 “If you take 200 voxels”: Brockman, p. 236. + +5 Dr. Brian Pasley and his colleagues: Visit to Dr. Pasley’s laboratory +on July 11, 2012, at the University of California, Berkeley. + +6 Similar results were obtained: The Brain Institute, University of +Utah, Salt Lake City, http://brain.utah.edu. + +7 This could have applications for artists: http://io9/543338/a- +device-that-lets-io9.com/543338/a-device-that-lets-ou-type-with-your- +mind. + +8 According to their officials: http://news.discovery.com/tech/type- +with-your-mind-110309.html. + +9 being explored by Dr. David Poeppel: Discover Magazine Presents the +Brain, Spring 2012, p. 43. + +10 In 1993 in Germany: Scientific American, November 2008, p. 68. + +11 The only justification for its existence: Garreau, pp. 23-24. + +12 I once had lunch with: Symposium on the future of science +sponsored by the Science Fiction Channel at the Chabot Pace and +Science Center, Oakland, California, in May 2004." +"13 On another occasion: Conference in Anaheim, California, April +2009. + +14 He says, “Imagine if soldiers”: Garreau, p. 22. + +15 “What he is doing is spending”: Ibid., p. 19. + +16 When I asked Dr. Nishimoto: Visit to Dr. Gallant’s laboratory at the +University of California, Berkeley, on July 11, 2012. + +17 “There are ethical concerns”: http://www.nbcnews.com/ +id/47447302/ns/health-health_care/t/paralyzed-woman-gets-robotic- +arm.html. + +CHAPTER 4: TELEKINESIS: MIND CONTROLLING MATTER + + 1 “I would love to have”: New York Times, May 17, 2012, p. A17 and +http://www.msnbc.mns.eom/id/47447302/ns/health-health_care/t/ +parallyzed-woman-gets-robotic-arm.html. + +2 “We have taken a tiny sensor”: Interview with Dr. John Donoghue in +November 2009 for Science Fantastic national radio broadcast. + +3 In the United States alone, more than two hundred thousand: + +Centers for Disease Control and Prevention, Washington, D.C. http:// +www. ede. go v/traumatiebraininj ury/scifacts. html ." +"4 When the monkey wanted to move: + +http://physio.northwestern.edu/faculty/miller.htm; http://www. + +northwestern.edu/newscenter/stories/2012/04/miller-paralyzed- + +technology.html. + +5 “We are eavesdropping on the natural”: http://www.northwestern. +edu/newscenter/stories/2012/04/miller-paralyzed-technology.html. + +6 More than 1,300 service members: http://www.darpa.mil/Our_ +Work/DSO/Programs/Revolutionizing_Prosthetics.aspx. CBS 60 +Minutes, broadcast on December 30, 2012. + +7 “They thought we were crazy”: Ibid. + +8 she appeared on 60 Minutes: Ibid. + +9 “There’s going to be a whole ecosystem”: Wall Street Journal, May +29, 2012. + +10 But perhaps the most novel applications: Interview with Dr. +Nicolelis in April 2011 for Science Fantastic national radio broadcast." +"11 Smart Hands and Mind Melds: New York Times, March 13, 2013, +http://nytimes.com/2013/03/01/science/new-research-suggests-two- +rat-brains-can-be-linked. See also Huffington Post, February 28, 2013, +http://www.huffingtonpost.com/2013/02/28/mind-melds-brain- +communication_n_2781609.html. + +12 In 2013, the next important step: USA Today, August 8, 2013, p. +ID. + + 13 About ten years ago: Interview with Dr. Nicolelis in April 2011. + +14 “so there’s nothing sticking out”: For a full discussion of the +exoskeleton, see Nicolelis, pp. 303-7. + +15 The Honda Corporation has: http://www.asimo.honda.com. Also, +interview with the creators of ASIMO in April 2007 for the BBC-TV +series Visions of the Future. + +16 Eventually, you get the hang: http://discovermagazine.com/2007/ +may/re vie w-test- driving- the -future . + +17 Then, by thinking, the patient: Discover, December 9, 2011, http:// +discovermagazine.com/2011/dec/09-mind-over-motor-controlling- +robots-with-your-thoughts." +"18 “We will likely be able to operate”: Nicolelis, p. 315. + +19 I saw a demonstration of this: Interview with the scientists at +Carnegie Mellon in August 2010 for the Discovery/Science Channel TV +series Sci Fi Science. + +CHAPTER 5: MEMORIES AND THOUGHTS MADE TO ORDER + +1 “It has all come together”: Wade, p. 89. + +2 So far, scientists have identified: Ibid., p. 91. + +3 For instance, Dr. Antonio Damasio: Damasio, pp. 130-53. + +4 One fragment of memory might: Wade, p. 232. + +5 “If you can’t do it”: http://www.newscientist.com/article/dn3488. + +6 “Turn the switch on”: http://www.eurekalert.org/pub_releases/2011- +06/uosc-rmr06211 .php. + +7 “Using implantables to enhance competency”: http://hplus +magazine.com/2009/03/18/artificial-hipppocampus. + +8 Not surprisingly, with so much at stake: http://articles. +washingtonpost.com/2013-07-12/national/40863765_l_brain-cells- +mice-new-memories." +"9 If encoding the memory: This brings up the question of whether +carrier pigeons, migratory birds, whales, etc., have a long-term +memory, given that they can migrate over hundreds to thousands of + + miles in search of feeding and breeding grounds. Science knows little +about this question. But it is believed that their long-term memory is +based on locating certain landmarks along the way, rather than +recalling elaborate memories of past events. In other words, they do +not use memory of past events to help them simulate the future. Their +long-term memory consists of just a series of markers. Apparently, +only in humans are long-term memories used to help simulate the +future. + +10 “The purpose of memory is”: Michael Lemonick, “Your Brain: A +User’s Guide,” Time, December 2011, p. 78. + +11 “You might look at it”: http://sciencedaily.com/videos/2007/0210- +brain_scans_of_the_future.htm. + +12 their study proves a “tentative answer”: http://www.sciencedaily. +com/videos/2007/0710." +"12 their study proves a “tentative answer”: http://www.sciencedaily. +com/videos/2007/0710. + +13 “The whole idea is that the device”: New York Times, September + +12, 2012, p. A18. + +14 “It will likely take us”: http://www.tgdaily.com/general-sciences- +features/58736-artificial-cerebellum-restores-rats. + +15 There are 5.3 million Americans: Alzheimer’s Foundation of +America, http://www.alzfdn.org. + +16 “This adds to the notion”: ScienceDaily.com, October 2009, http:// +www.sciencedaily.com/releases/2009/10/091019122647.htm. + +17 “We can never turn it into”: Ibid. + +18 “This implies these flies have”: Wade, p. 113. + +19 This effect is not just restricted: Ibid. + +20 “We can now give you”: Ibid., p. 114. + +21 Basically, the more CREB proteins: Bloom, p. 244. + +22 “Propranolol sits on that nerve cell”: SATI e-News, June 28, 2007, +http://www.mysati.com/enews/June2007/ptsd.htm. + +23 Its report concluded: Boleyn-Fitzgerald, p. 104. + +24 “Our breakups, our relationships”: Ibid." +"23 Its report concluded: Boleyn-Fitzgerald, p. 104. + +24 “Our breakups, our relationships”: Ibid. + + 25 “should we deprive them of morphine”: Ibid., p. 105. + +26 “If further work confirms this view”: Ibid., p. 106. + +27 “Each of these perennial records”: Nicolelis, p. 318. + +28 “Forgetting is the most beneficial process”: New Scientist, March +12, 2003, http://www.newscientists.com/article/dn3488. + +CHAPTER 6: EINSTEIN’S BRAIN AND ENHANCING INTELLIGENCE + +1 “got caught up in the moment”: + +http://abcnews.go.com/blogs/headlines/2012/03/einsteins-brain- + +arrives-in-london-after-odd-journey. + +2 “I have always maintained that”: Gould, p. 109. + +3 “The human brain remains ‘plastic’ ”: www.sciencedaily.com/ +releases/2011/12/111208257120.htm. + +4 “The emerging picture from such studies”: Gladwell, p. 40. + +5 Five years later, Terman started: See C. K. Holahan and R.R. Sears, +The Gifted Group in Later Maturity (Stanford, CA: Stanford University +Press, 1995)." +"6 “Your grades in school”: Boleyn-Fitzgerald, p. 48. + +7 “Tests don’t measure motivation”: Sweeney, p. 26. + +8 The pilots who scored highest: Bloom, p. 12. + +9 “The left hemisphere is responsible”: Ibid., p. 15. + +10 Dr. Darold Treffert, a Wisconsin physician: http://www.darold +treffert.com. + +11 It took him just forty-five seconds: Tammet, p. 4. + +12 I had the pleasure of interviewing: Interview with Mr. Daniel +Tammet in October 2007 for Science Fantastic national radio broadcast. + +13 “Our study confirms”: Science Daily, March 2012, http://www. +sciencedaily.com/releases/2012/03/120322100313.htm. + + 14 Kim Peek’s brain: AP wire story, November 8, 2004, http://www. +Space.com. + +15 In 1998 , Dr. Bruce Miller: Neurology 51 (October 1998): pp. 978- +82. See also http://www.wisconsinmedicalsociety.org/savant_ +syndrome/savant-articles/acquired_savant. + +16 In addition to the savants: Sweeney, p. 252." +"16 In addition to the savants: Sweeney, p. 252. + +17 This idea has actually been tried: Center of the Mind, Sydney, +Australia, http://www.centerofthemind.com. + +18 In another experiment, Dr. R. L. Young: R. L. Young, M. C. +Ridding, and T. L. Morrell, “Switching Skills on by Turning Off Part of +the Brain,” Neurocase 10 (2004): 215, 222. + +19 “When applied to the prefrontal lobes”: Sweeney, p. 311. + +20 Until recently, it was thought: Science Daily, May 2012, http:// +www.sciencedaily.com/releases/2012/05/120509180113.htm. + +21 “Savants have a high capacity”: Ibid. + +22 In 2007 , a breakthrough occurred: Sweeney, p. 294. + +23 “Stem cell research and regenerative medicine”: Sweeney, p. 295. + +24 Scientists have focused on a few genes: Katherine S. Pollard, +“What Makes Us Different,” Scientific American Special Collectors Edition +(Winter 2013): 31-35. + +25 “I jumped at the opportunity”: Ibid. + +26 “With my mentor David Haussler”: Ibid." +"25 “I jumped at the opportunity”: Ibid. + +26 “With my mentor David Haussler”: Ibid. + +27 One such gene was discovered: TG Daily, November 15, 2012. +http://www.tgdaily.com/general-sciences-features/67503-new-found- +gene-separates-man-from-apes. + +28 Many theories have been proposed: See, for example, Gazzaniga, +Human: The Science Behind What Makes Us Unique. + +29 “For the first few hundred million years”: Gilbert, p. 15. + +30 “Cortical gray matter neurons are working”: Douglas Fox, “The +Limits of Intelligence,” Scientific American, July 2011, p. 43. + +31 “You might call it the mother”: Ibid., p. 42. + + CHAPTER 7: IN YOUR DREAMS + +1 He followed this up with one thousand: C. Hall and R. Van de + +Castle, The Content Analysis of Dreams (New York: Appleton-Century- +Crofts, 1966). + +2 When I interviewed him, he told me: Interview with Dr. Allan +Hobson in July 2012 for Science Fantastic national radio broadcast. + +3 Studies have shown that it is possible: Wade, p. 229." +"3 Studies have shown that it is possible: Wade, p. 229. + +4 ATR chief scientist Yukiyasu Kamitani: New Scientist, December 12, + +2008, http://www.newscientist.com/article/dnl 6267-mindreading- + +software-could-record-your-dreams.html#.UvE9P0Qi07s. + +5 When I visited the laboratory: Visit to Dr. Gallant’s laboratory on +July 11, 2012. + +6 “Our dreams are therefore not”: Science Daily, October 28, 2011, +http://www.sciencedaily.com/releases/2011/10/111028113626.htm. + +7 Already, prototypes of Internet contact lenses: See the work of Dr. +Babak Parviz, http://www.wearable-technologies.com/262. + +CHAPTER 8: CAN THE MIND BE CONTROLLED? + +1 A raging bull is released: Miguel Nicolelis, Beyond Boundaries (New +York: Henry Holt, 2011), pp. 228-32. + +2 The cold war hysteria eventually reached: “Project MKUltra, the" +"2 The cold war hysteria eventually reached: “Project MKUltra, the + +CIA’s Program of Research into Behavioral Modification. Joint +Hearings Before the Select Committee on Human Resources, U.S. +Senate, 95th Congress, First Session,” Government Printing Office, +August 8, 1977, Washington, D.C., http://www.nytimes.com/ + +packages/pdf/national/13inmate_ProjectMKULTRA.pdf; “CIA Says It +Found More Secret Papers on Behavior Control,” New York Times, +September 3, 1977; “Government Mind Control Records of MKUltra +and Bluebird/Artichoke,” http://wanttoknow.info/mindcontrol.shtml; +“The Select Committee to Study Governmental Operations with" +"Respect to Intelligence Activities, Foreign and Military Intelligence.” +The Church Committee Report No. 94-755, 94th Congress, 2nd +Session, p. 392, Government Printing Office, Washington, D.C., 1976; +“Project MKUltra, the CIA’s Program of Research in Behavior +Modification,” http://scribd.com/doc/75512716/Project-MKUltra- +The-CIA-s-Program-of-Research-in-Behavior-Modification. + +3 “great potential for development”: Rose, p. 292. + +4 “neuro-scientific impossibility”: Ibid., p. 293. + +5 “It is probably significant that”: “Hypnosis in Intelligence,” Black +Vault Freedom of Information Act Archive, 2008, http://documents. +theblackvault.com/documents/mindcontrol/hypnosisinintelligence. +pdf. + +6 To see how widespread this problem: Boleyn-Fitzgerald, p. 57. + +7 Drugs like LSD: Sweeney, p. 200. + +8 “This is the first time we’ve shown”: Boleyn-Fitzgerald, p. 58. + +9 “If you want to turn off”: http://www.nytimes.com/2011/05/17/ +science/17optics.html." +"9 “If you want to turn off”: http://www.nytimes.com/2011/05/17/ +science/17optics.html. + +10 “By feeding information from sensors”: New York Times, March 17, +2011, http://nytimes.com/2011/05/17/science/17optics.html. + +CHAPTER 9: ALTERED STATES OF CONSCIOUSNESS + +1 “Some fraction of history’s prophets”: Eagleman, p. 207. + +2 “Sometimes it’s a personal God”: Boleyn-Fitzgerald, p. 122. + +3 “ ‘Finally, I see what it is’ ”: Ramachandran, p. 280. + +4 “During the three minute bursts”: David Biello, Scientific American, +p. 41, www.sciammind.com. + +5 To test these ideas: Ibid., p. 42. + +6 “Although atheists might argue”: Ibid., p. 45. + +7 “If you are an atheist”: Ibid., p. 44. + +8 One theory holds that Parkinson’s: Sweeney, p. 166. + + 9 “Neurons wired for the sensation”: Ibid., p. 90. + +10 “The brain’s gonna do what”: Ibid., p. 165. + +11 “Brain scans have led researchers”: Ibid., p. 208. + +12 “If left unchecked, the left hemisphere”: Ramachandran, p. 267. + +13 Underactivity in this area: Carter, pp. 100-103." +"13 Underactivity in this area: Carter, pp. 100-103. + +14 Ten percent of them, in turn: Baker, pp. 46-53. + +15 “Depression 1.0 was psychotherapy”: Ibid., p. 3. + +16 One to three percent of DBS patients: Carter, p. 98. + +17 “The calcium channels findings suggest”: New York Times, + +February 26, 2013, http://www.nytimes.com/2013/03/01/ + +health/study-finds-genetic-risk-factors-shared-by-5-psychiatric- +disorders.html. + +18 “What we have identified here”: Ibid. + +CHAPTER 10: THE ARTIFICIAL MIND AND SILICON CONSCIOUSNESS + +1 “Machines will be capable”: Crevier, p. 109. + +2 “within a generation ... the problem”: Ibid. + +3 “It’s as though a group of people”: Kaku, p. 79. + +4 “I would pay a lot for a robot”: Brockman, p. 2. + +5 However, I met privately with: Interview with the creators of ASIMO +during a visit to Honda’s laboratory in Nagoya, Japan, in April 2007 +for the BBC-TV series Visions of the Future." +"6 he used to marvel at the mosquito: Interview with Dr. Rodney +Brooks in April 2002 for Exploration national radio broadcast. + +7 I have had the pleasure of visiting: Visit to MIT Media Laboratory +for the Discovery/Science Channel TV series Sci Fi Science, April 13, +2010 . + +8 “That is why Breazeal decided”: Moss, p. 168. + + 9 At Waseda University: Gazzaniga, p. 352. + +10 Their goal is to integrate: Ibid., p. 252. + +11 Meet Nao: Guardian, August 9, 2010, http://www.theguardian.com/ +technology/2010/aug/09/nao-robot-develop-display-emotions. + +12 “It’s hard to predict the future”: http://cosmomagazine.com/news/ +4177/reverse-engineering-brain. + +13 Neuroscientists like Dr. Antonio Damasio: Damasio, pp. 108-29. + +14 “In mathematics, you don’t understand”: Kurzweil, p. 248. + +15 “There could not be an objective test”: Pinker, “The Riddle of +Knowing You’re Here,” Your Brain: A User’s Guide, Winter, 2011, p. 19. + +16 At Meiji University: Gazzaniga, p. 352." +"16 At Meiji University: Gazzaniga, p. 352. + +17 “To our knowledge, this is the first”: Kurzweil.net, August 24, + +2012, http://www.kurzweilai.net/robot-learns-self-awareness. See also +Yale Daily News, September 25, 2012, + +http://yaledailynews.com/blog/2012/09/25/first-self-aware-robot- +created. + +18 When I interviewed Dr. Hans Moravec: Interview with Dr. Hans +Moravec in November 1998 for Exploration national radio broadcast. + +19 “Unleashed from the plodding pace”: Sweeney, p. 316. + +20 When I interviewed Dr. Rodney Brooks: Interview with Dr. Brooks +in April 2002 for Exploration national radio broadcast. + +21 “We don’t like to give up”: TEDTalks, http://www.ted.com/talks/ +lang/en/rodney_brooks_on_robots.html. + +22 Similarly, at the University of Southern California: http://phys. +org/news205059692.html. + +CHAPTER 11: REVERSE ENGINEERING THE BRAIN + +1 Almost simultaneously, the European Commission: http://actu. +epfl.ch/news/the-human-brain-project-wins-top-european-science." +"2 “It’s essential for us to understand”: + +http://blog.ted.eom/2009/l 0/15/supercomputing. + +3 “There’s not a single neurological disease”: Kushner, p. 19. + +4 “I think we’re far from playing God”: Ibid., p. 2. + +5 “In a hundred years, I’d like”: Sally Adee, “Reverse Engineering the +Brain,” IEEE Spectrum, http://spectrum.ieee.org/biomedical/ethics/ +reverse-engineering-the-brain. + +6 “Researchers have conjectured”: + +http://www.cnn.corn/2012/03/01/tech/innovation/brain-map- + +connectome. + +“In the seventeenth century”: + +http: //www. ted. com/talks/lang/en/sebastian_seung .html . + +8 “The Allen Human Brain Atlas provides”: http://ts-si.org/ +neuroscience/29735-allen-human-brain-atlas-updates-with- +comprehensive). + +9 According to Dr. V. S. Ramachandran: TED Talks, January 2010, +http://www.ted.com. + +CHAPTER 12: THE FUTURE: MIND BEYOND MATTER + +1 5.8 percent claimed they had an out-of-body: Nelson, p. 137. + +2 “I see myself lying in bed”: Ibid., p. 140." +"2 “I see myself lying in bed”: Ibid., p. 140. + +3 Notably, temporary loss of blood: National Geographic News, April 8, +2010, http://news.nationalgeographic.eom/news/2010/04/100408- +near-death-experiences-blood-carbon-dioxide; Nelson, p. 126 + +4 Dr. Thomas Lempert, neurologist: Nelson, p. 126. + +5 The U.S. Air Force, for example: Ibid., p. 128. + +6 We once spoke at a conference: Dubai, United Arab Emirates, +November 2012. Interviewed in February 2003 for Exploration +national radio broadcast. Interviewed in October 2012 for Science + + Fantastic national radio broadcast. + +7 By 2055, $1,000 of computing power: Bloom, p. 191. + +8 For example, Bill Gates, cofounder: Sweeney, p. 298. + +9 “People who predict a very utopian future”: Carter, p. 298. + +10 He told me that the San Diego Zoo: Interview with Dr. Robert +Lanza in September 2009 for Exploration national radio broadcast. + +11 “Should we ridicule the modern seekers”: Sebastian Seung, +TEDTalks, http://www.ted.com/talks/lang/en/sebastian_seung.html ." +"12 In 2008, BBC-TV aired: http://www.bbc.co.uk/sn/tvradio/ +programmes/horizon/broadband/tx/isolation/timeline. + +13 we will be able to reverse engineer: Interview with Dr. Moravec in +November 1998 for Exploration national radio broadcast. + +14 On the other side was Eric Drexler: See a series of letter in +Chemical and Engineering News from 2003 to 2004. + +15 “I’m not planning to die”: Garreau, p. 128. + +CHAPTER 13: THE MIND AS PURE ENERGY + +1 “Wormholes, extra dimensions”: Sir Martin Rees, Our Final Hour +(New York: Perseus Books, 2003), p. 182. + +CHAPTER 14: THE ALIEN MIND + +1 So far, more than one thousand: Kepler Web Page, http://kepler. +nasa.gov. + +2 In 2013, NASA scientists announced: Ibid. + +3 how they can distinguish false messages: Interview with Dr. +Wertheimer in June 1999 for Exploration national radio broadcast. + +4 I once asked him about the giggle factor: Interview with Dr. Seth +Shostak in May 2012 for Science Fantastic national radio broadcast. + +5 He has gone on record: Ibid." +"5 He has gone on record: Ibid. + + 6 “Remember, this is the same government”: Davies, p. 22. + +7 The Greek writers: Sagan, p. 221. + +8 But St. Thomas Aquinas: Ibid. + +9 We can be fooled: Ibid. + +10 “If the fact that brutes abstract”: Ibid., p. 113. + +11 “In the blind and deaf world”: Eagleman, p. 77. + +12 we have to expand our own horizon: Interview with Dr. Paul +Davies in April 2012 for Science Fantastic national radio broadcast. + +13 “My conclusion is a startling one”: Davies, p. 159. + +14 “Although there is only a tiny probability”: Discovery News, +December 27, 2011, http://news.discovery.com/space/seti-to-scour- +the-moon-for-alien-tech-111227.htm. + +CHAPTER 15: CONCLUDING REMARKS + +1 In an article in Wired: Wired, April 2000, http://www.wired.com/ +wired/archive/8.04/joy.html. + +2 “several separate and unequal species”: Garreau, p. 139. + +3 “This techno utopia is all about”: Ibid., p. 180. + +4 “The idea that we are messin’ ”: Ibid., p. 353. + +5 “Technologies—such as gunpowder”: Ibid., p. 182." +"5 “Technologies—such as gunpowder”: Ibid., p. 182. + +6 “The you that all your friends know”: Eagleman, p. 205. + +7 “Our reality depends on what”: Ibid., p. 208. + +8 “How it is that anything so remarkable”: Pinker, p. 132. + +9 somehow create a twin of the Earth: Interview with Dr. Stephen Jay +Gould in November 1996 for Exploration national radio broadcast. + +10 “ Homo sapiens is one small twig”: Pinker, p. 133. + +11 “nothing gives life more purpose”: Pinker, “The Riddle of Knowing +You’re Here,” Time: Your Brain: A User’s Guide (Winter 2011), p. 19. + + 12 “What a perplexing masterpiece”: Eagleman, p. 224. + +APPENDIX: QUANTUM CONSCIOUSNESS? + +1 many (but not all) pathological killers: Interview with Dr. Simon +Baron-Cohen in July 2005 for Exploration national radio broadcast. + +2 Dr. Michael Sweeney concludes, “Libet’s findings”: Sweeney, p. +150. + +SUGGESTED READING + +Baker, Sherry. “Helen Mayberg.” Discover Magazine Presents the Brain. +Waukesha, WI: Kalmbach Publishing Co., Fall 2012." +"Bloom, Floyd. Best of the Brain from Scientific American: Mind, Matter, and +Tomorrow’s Brain. New York: Dana Press, 2007. + +Boleyn-Fitzgerald, Miriam. Pictures of the Mind: What the New +Neuroscience Tells Us About Who We Are. Upper Saddle River, N.J.: +Pearson Education, 2010. + +Brockman, John, ed. The Mind: Leading Scientists Explore the Brain, +Memory, Personality, and Happiness. New York: Harper Perennial, 2011. + +Calvin, William H. A Brief History of the Mind. New York: Oxford +University Press, 2004. + +Carter, Rita. Mapping the Mind. Berkeley: University of California Press, +2010 . + +Crevier, Daniel. AT. The Tumultuous History of the Search for Artificial +Intelligence. New York: Basic Books, 1993. + +Crick, Francis. The Astonishing Hypothesis: The Science Search for the Soul. +New York: Touchstone, 1994. + +Damasio, Antonio. Self Comes to Mind: Constructing the Conscious Brain. +New York: Pantheon Books, 2010." +"Davies, Paul. The Eerie Silence: Renewing Our Search for Alien Intelligence. +New York: Houghton Mifflin Harcourt, 2010. + +Dennet, Daniel C. Breaking the Spell: Religion as a Natural Phenomenon. +New York: Viking, 2006. + + -. Conscious Explained. New York: Back Bay Books, 1991. + +DeSalle, Rob, and Ian Tattersall. The Brain: Big Bangs, Behaviors, and +Beliefs. New Haven, CT: Yale University Press, 2012. + +Eagleman, David. Incognito: The Secret Lives of the Brain. New York: + +Pantheon Books, 2011. + +Fox, Douglas. “The Limits of Intelligence,” Scientific American, July 2011. + +Garreau, Joel. Radical Evolution: The Promise and Peril of Enhancing Our +Minds , Our Bodies—and What It Means to Be Human. New York: +Random House, 2005. + +Gazzaniga, Michael S. Human: The Science Behind What Makes Us Unique. +New York: HarperCollins, 2008. + +Gilbert, Daniel. Stumbling on Happiness. New York: Alfred A. Knopf, + +2006. + +Gladwell, Malcolm. Outliers: The Story of Success. New York: Back Bay +Books, 2008." +"2006. + +Gladwell, Malcolm. Outliers: The Story of Success. New York: Back Bay +Books, 2008. + +Gould, Stephen Jay. The Mismeasure of Man. New York: W. W. Norton, +1996. + +Horstman, Judith. The Scientific American Brave New Brain. San +Francisco: John Wiley and Sons, 2010. + +Kaku, Michio. Physics of the Future. New York: Doubleday, 2009. + +Kurzweil, Ray. How to Create a Mind: The Secret of Human Thought +Revealed. New York: Viking Books, 2012. + +Kushner, David. “The Man Who Builds Brains.” Discover Magazine +Presents the Brain. Waukesha, WI: Kalmbach Publishing Co., Fall 2001. + +Moravec, Hans. Mind Children: The Future of Robot and Human +Intelligence. Cambridge, MA: Harvard University Press, 1988. + +Moss, Frank. The Sorcerers and Their Apprentices: How the Digital +Magicians of the MIT Media Lab Are Creating the Innovative Technologies +That Will Transform Our Lives. New York: Crown Business, 2011. + + Nelson, Kevin. The Spiritual Doorway in the Brain. New York: Dutton, +2011." +"Nelson, Kevin. The Spiritual Doorway in the Brain. New York: Dutton, +2011. + +Nicolelis, Miguel. Beyond Boundaries: The New Neuroscience of Connecting +Brains with Machines—and How It Will Change Our Lives. New York: +Henry Holt and Co., 2011. + +Pinker, Steven. How the Mind Works. New York: W. W. Norton, 2009. + +-. The Stuff of Thought: Language as a Window into Human + +Nature. New York: Viking, 2007. + +-. “The Riddle of Knowing You’re Here.” In Your Brain: A + +User’s Guide. New York: Time Inc. Specials, 2011. + +Piore, Adam. “The Thought Helmet: The U.S. Army Wants to Train +Soldiers to Communicate Just by Thinking.” The Brain, Discover +Magazine Special, Spring 2012. + +Purves, Dale, et al., eds. Neuroscience. Sunderland, MA: Sinauer +Associates, 2001. + +Ramachandran, V. S. The Tell-Tale Brain: A Neuroscientist’s Quest for What +Makes Us Human. New York: W. W. Norton, 2011." +"Rose, Steven. The Future of the Brain: The Promise and Perils of Tomorrow’s +Neuroscience. Oxford, UK: Oxford University Press, 2005. + +Sagan, Carl. The Dragons of Eden: Speculations on the Evolution of Human +Intelligence. New York: Ballantine Books, 1977. + +Sweeney, Michael S. Brain: The Complete Mind: How It Develops, How It +Works, and How to Keep It Sharp. Washington, D.C.: National +Geographic, 2009. + +Tammet, Daniel. Bom on a Blue Day: Inside the Extraordinary Mind of an +Autistic Savant. New York: Free Press, 2006. + +Wade, Nicholas, ed. The Science Times Book of the Brain. New York: New +York Times Books, 1998. + +ILLUSTRATION CREDITS + + 1.1 Jeffrey L. Ward + +1.2 Jeffrey L. Ward + +1.3 Jeffrey L. Ward + +1.4 Jeffrey L. Ward + +1.5 AP Photo / David Duprey + +1.5a Tom Barrick, Chris Clark / Science Source + +1.6 Jeffrey L. Ward + +2.1 Jeffrey L. Ward + +2.2 Jeffrey L. Ward + +2.3 Jeffrey L. Ward + +4.1 The Laboratory of Dr. Miguel Nicolelis, Duke University + +5.1 Jeffrey L. Ward" +"4.1 The Laboratory of Dr. Miguel Nicolelis, Duke University + +5.1 Jeffrey L. Ward + +10.1 MIT Media Lab, Personal Robots Group + +10.2 MIT Media Lab, Personal Robots Group, Mikey Siegel + +A Note About the Author + +MICHIO KAKU is a professor of theoretical physics at the City College +and City University of New York; cofounder of string field theory; the +author of several widely acclaimed science books, including Hyperspace, +Beyond Einstein, Physics of the Impossible, and Physics of the Future; and +host of numerous TV specials and a national science radio show. + +Other titles by Michio Kaku available in eBook format +Parallel Worlds • 9780385514163 +Physics of the Future • 9780385530811 +Physics of the Impossible • 9780385525442 + +Visions • 9780307794772 + +Visit mkaku.org + +For more information on Doubleday books + + Visit: www.doubleday.com +Like: facebook.com/DoubledayBooks +Follow: @doubledaypub + +ALSO BY THE AUTHOR + +Physics of the Future +Physics of the Impossible +Parallel Worlds +Hyperspace +Visions" +"Physics of the Future +Physics of the Impossible +Parallel Worlds +Hyperspace +Visions + +Einstein’s Cosmos +Beyond Einstein" +"DR. MICHIO KAMI + +PROFESSOR OF THEORETICAL PHYSICS +CITY UNIVERSITY OI : NEW YORK + +THE SCIENTIFIC QUEST TO UNDERSTAND +ENHANCE, AND EMPOWER THE MIND + +DOUBLEPAY + +NEW YORK LONDON TORONTO + +SYDNEY AUCKLAND + +Copyright © 2014 by Michio Kaku + +All rights reserved. Published in the United States by Doubleday, a division of Random House, +LLC, New York, and in Canada by Random House of Canada Limited, Toronto, Penguin Random +House companies. + +www.doubleday.com + +doubleday and the portrayal of an anchor with a dolphin are registered trademarks of Random +House, LLC. + +Illustrations by Jeffrey L. Ward +Jacket design by Michael J. Windsor + + Jacket illustration © CLIP AREA/Custom media/Shutterstock +LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA +Kaku, Michio. + +The future of the mind : the scientific quest to understand, enhance, and empower the mind / +Dr. Michio Kaku, professor of Theoretical Physics, City University of New York. — First edition, +pages cm + +Includes bibliographical references." +"Includes bibliographical references. + +1. Neuropsychology. 2. Mind and body—Research. + +3. Brain—Mathematical models. 4. Cognitive neuroscience. + +5. Brain-computer interfaces. I. Title. +qp360.k 325 2014 +612.8—dc23 + +2013017338 + +ISBN 978-0-385-53082-8 (hardcover) ISBN 978-0-385-53083-5 (eBook) + +v3.1 + +This book is dedicated to my loving wife, Shizue, + +and my daughters, Michelle and Alyson + +CONTENTS + +Cover + +Title Page + +Copyright + +Dedication + +ACKNOWLEDGMENTS + +INTRODUCTION + + BOOK I: THE MIND AND CONSCIOUSNESS + +1 UNLOCKING THE MIND + +2 CONSCIOUSNESS—A PHYSICIST’S VIEWPOINT + +BOOK II: MIND OVER MATTER + +3 TELEPATHY: A PENNY FOR YOUR THOUGHTS + +4 TELEKINESIS: MIND CONTROLLING MATTER + +5 MEMORIES AND THOUGHTS MADE TO ORDER + +6 EINSTEIN’S BRAIN AND ENHANCING OUR INTELLIGENCE + +BOOK III: ALTERED CONSCIOUSNESS + +7 IN YOUR DREAMS + +8 CAN THE MIND BE CONTROLLED? + +9 ALTERED STATES OF CONSCIOUSNESS + +10 THE ARTIFICIAL MIND AND SILICON CONSCIOUSNESS + +11 REVERSE ENGINEERING THE BRAIN" +"10 THE ARTIFICIAL MIND AND SILICON CONSCIOUSNESS + +11 REVERSE ENGINEERING THE BRAIN + +12 THE FUTURE: MIND BEYOND MATTER + +13 THE MIND AS PURE ENERGY + +14 THE ALIEN MIND + +15 CONCLUDING REMARKS + +APPENDIX: QUANTUM CONSCIOUSNESS? + +NOTES + +SUGGESTED READING +ILLUSTRATION CREDITS +A Note About the Author + +Other Books by This Author + +ACKNOWLEDGMENTS + + It has been my great pleasure to have interviewed and interacted with +the following prominent scientists, all of them leaders in their fields. I +would like to thank them for graciously giving up their time for +interviews and discussions about the future of science. They have given +me guidance and inspiration, as well as a firm foundation in their +respective fields. + +I would like to thank these pioneers and trailblazers, especially those +who have agreed to appear on my TV specials for the BBC, Discovery, +and Science TV channels, and also on my national radio shows, Science +Fantastic and Explorations." +"Peter Doherty, Nobel laureate, St. Jude Children’s Research Hospital + +Gerald Edelman, Nobel laureate, Scripps Research Institute + +Leon Lederman, Nobel laureate, Illinois Institute of Technology + +Murray Gell-Mann, Nobel laureate, Santa Fe Institute and Cal Tech + +the late Henry Kendall, Nobel laureate, MIT + +Walter Gilbert, Nobel laureate, Harvard University + +David Gross, Nobel laureate, Kavli Institute for Theoretical Physics + +Joseph Rotblat, Nobel laureate, St. Bartholomew’s Hospital + +Yoichiro Nambu, Nobel laureate, University of Chicago + +Steven Weinberg, Nobel laureate, University of Texas at Austin + +Frank Wilczek, Nobel laureate, MIT + +Amir Aczel, author of Uranium Wars + +Buzz Aldrin, NASA astronaut, second man to walk on the moon +Geoff Andersen, U.S. Air Force Academy, author of The Telescope + +Jay Barbree, author of Moon Shot + +John Barrow, physicist, Cambridge University, author of Impossibility + +Marcia Bartusiak, author of Einstein’s Unfinished Symphony" +"Marcia Bartusiak, author of Einstein’s Unfinished Symphony + + Jim Bell, Cornell University astronomer + +Jeffrey Bennet, author of Beyond UFOs + +Bob Berman, astronomer, author The Secrets of the Night Sky + +Leslie Biesecker, National Institutes of Health + +Piers Bizony, author of How to Build Your Own Starship + +Michael Blaese, National Institutes of Health + +Alex Boese, founder of Museum of Hoaxes + +Nick Bostrom, transhumanist, Oxford University + +Lt. Col. Robert Bowman, Institute for Space and Security Studies + +Cynthia Breazeal, artificial intelligence, MIT Media Lab + +Lawrence Brody, National Institutes of Health + +Rodney Brooks, director of the MIT Artificial Intelligence Laboratory +Lester Brown, Earth Policy Institute +Michael Brown, astronomer, Cal Tech +James Canton, author of The Extreme Future + +Arthur Caplan, director of the Center for Bioethics at the University of +Pennsylvania" +"Arthur Caplan, director of the Center for Bioethics at the University of +Pennsylvania + +Fritjof Capra, author of The Science of Leonardo +Sean Carroll, cosmologist, Cal Tech +Andrew Chaikin, author of A Man on the Moon +Leroy Chiao, NASA astronaut + +Eric Chivian, International Physicians for the Prevention of Nuclear +War + +Deepak Chopra, author of Super Brain + +George Church, director of Harvard’s Center for Computational +Genetics + +Thomas Cochran, physicist, Natural Resources Defense Council + +Christopher Cokinos, astronomer, author of Fallen Sky + + Francis Collins, National Institutes of Health + +Vicki Colvin, nanotechnologist, University of Texas + +Neal Comins, author of Hazards of Space Travel + +Steve Cook, NASA spokesperson + +Christine Cosgrove, author of Normal at Any Cost + +Steve Cousins, CEO of Willow Garage Personal Robots Program + +Phillip Coyle, former assistant secretary of defense for the U.S. Defense +Department + +Daniel Crevier, AI, CEO of Coreco" +"Daniel Crevier, AI, CEO of Coreco + +Ken Croswell, astronomer, author of Magnificent Universe + +Steven Cummer, computer science, Duke University + +Mark Cutkowsky, mechanical engineering, Stanford University + +Paul Davies, physicist, author of Superforce + +Daniel Dennet, philosopher, Tufts University + +the late Michael Dertouzos, computer science, MIT + +Jared Diamond, Pulitzer Prize winner, UCLA + +Marriot DiChristina, Scientific American + +Peter Dilworth, MIT AI Lab + +John Donoghue, creator of Braingate, Brown University +Ann Druyan, widow of Carl Sagan, Cosmos Studios +Freeman Dyson, Institute for Advanced Study, Princeton University +David Eagleman, neuroscientist, Baylor College of Medicine +John Ellis, CERN physicist + +Paul Erlich, environmentalist, Stanford University +Daniel Fairbanks, author of Relics of Eden + +Timothy Ferris, University of California, author of Coming of Age in the +Milky Way Galaxy + +Maria Finitzo, stem cell expert, Peabody Award winner + + Robert Finkelstein, AI expert" +"Maria Finitzo, stem cell expert, Peabody Award winner + + Robert Finkelstein, AI expert + +Christopher Flavin, World Watch Institute + +Louis Friedman, cofounder of the Planetary Society + +Jack Gallant, neuroscientist, University of California at Berkeley + +James Garwin, NASA chief scientist + +Evelyn Gates, author of Einstein’s Telescope + +Michael Gazzaniga, neurologist, University of California at Santa +Barbara + +Jack Geiger, cofounder, Physicians for Social Responsibility + +David Gelertner, computer scientist, Yale University, University of +California + +Neal Gershenfeld, MIT Media Lab + +Daniel Gilbert, psychologist, Harvard University + +Paul Gilster, author of Centauri Dreams + +Rebecca Goldberg, Environmental Defense Fund + +Don Goldsmith, astronomer, author of Runaway Universe + +David Goodstein, assistant provost of Cal Tech + +J. Richard Gott III, Princeton University, author of Time Travel in +Einstein’s Universe + +Late Stephen Jay Gould, biologist, Harvard University" +"Late Stephen Jay Gould, biologist, Harvard University + +Ambassador Thomas Graham, spy satellites and intelligence gathering + +John Grant, author of Corrupted Science + +Eric Green, National Institutes of Health + +Ronald Green, author of Babies by Design + +Brian Greene, Columbia University, author of The Elegant Universe +Alan Guth, physicist, MIT, author of The Inflationary Universe + + William Hanson, author of The Edge of Medicine + +Leonard Hayflick, University of California at San Francisco Medical +School + +Donald Hillebrand, Argonne National Labs, future of the car +Frank N. von Hippel, physicist, Princeton University + +Allan Hobson, psychiatrist, Harvard University +Jeffrey Hoffman, NASA astronaut, MIT + +Douglas Hofstadter, Pulitzer Prize winner, Indiana University, author +of Godel, Escher, Bach + +John Horgan, Stevens Institute of Technology, author of The End of +Science + +Jamie Hyneman, host of MythBusters + +Chris Impey, astronomer, author of The Living Cosmos + +Robert Irie, AI Lab, MIT" +"Chris Impey, astronomer, author of The Living Cosmos + +Robert Irie, AI Lab, MIT + +P. J. Jacobowitz, PC magazine + +Jay Jaroslav, MIT AI Lab + +Donald Johanson, anthropologist, discoverer of Lucy +George Johnson, New York Times science journalist +Tom Jones, NASA astronaut +Steve Kates, astronomer + +Jack Kessler, stem cell expert, Peabody Award winner +Robert Kirshner, astronomer, Harvard University +Kris Koenig, astronomer + +Lawrence Krauss, Arizona State University, author of Physics of Star +Trek + +Lawrence Kuhn, filmmaker and philosopher, Closer to Truth + +Ray Kurzweil, inventor, author of The Age of Spiritual Machines + +Robert Lanza, biotechnology, Advanced Cell Technologies + +Roger Launius, author of Robots in Space + + Stan Lee, creator of Marvel Comics and Spider-Man + +Michael Lemonick, senior science editor of Time + +Arthur Lerner-Lam, geologist, volcanist + +Simon LeVay, author of When Science Goes Wrong + +John Lewis, astronomer, University of Arizona + +Alan Lightman, MIT, author of Einstein’s Dreams" +"John Lewis, astronomer, University of Arizona + +Alan Lightman, MIT, author of Einstein’s Dreams + +George Linehan, author of Space One + +Seth Lloyd, MIT, author of Programming the Universe + +Werner R. Loewenstein, former director of Cell Physics Laboratory, +Columbia University + +Joseph Lykken, physicist, Fermi National Laboratory + +Pattie Maes, MIT Media Lab + +Robert Mann, author of Forensic Detective + +Michael Paul Mason, author of Head Cases: Stories of Brain Injury and +Its Aftermath + +Patrick McCray, author of Keep Watching the Skies + +Glenn McGee, author of The Perfect Baby + +James McLurkin, MIT, AI Lab + +Paul McMillan, director of Space Watch + +Fulvia Melia, astronomer, University of Arizona + +William Meller, author of Evolution Rx + +Paul Meltzer, National Institutes of Health + +Marvin Minsky, MIT, author of The Society of Minds + +Hans Moravec, author of Robot + +Late Phillip Morrison, physicist, MIT" +"Hans Moravec, author of Robot + +Late Phillip Morrison, physicist, MIT + + Richard Muller, astrophysicist, University of California at Berkeley +David Nahamoo, IBM Human Language Technology +Christina Neal, volcanist + +Miguel Nicolelis, neuroscientist, Duke University + +Shinji Nishimoto, neurologist, University of California at Berkeley + +Michael Novacek, American Museum of Natural History + +Michael Oppenheimer, environmentalist, Princeton University + +Dean Ornish, cancer and heart disease specialist + +Peter Palese, virologist, Mount Sinai School of Medicine + +Charles Pellerin, NASA official + +Sidney Perkowitz, author of Hollywood Science + +John Pike, GlobalSecurity.org + +Jena Pincott, author of Do Gentlemen Really Prefer Blondes? + +Steven Pinker, psychologist, Harvard University +Thomas Poggio, MIT, artificial intelligence +Correy Powell, editor of Discover magazine +John Powell, founder of JP Aerospace" +"Richard Preston, author of Hot Zone and Demon in the Freezer +Raman Prinja, astronomer, University College London + +David Quammen, evolutionary biologist, author of The Reluctant Mr. +Darwin + +Katherine Ramsland, forensic scientist + +Lisa Randall, Harvard University, author of Warped Passages + +Sir Martin Rees, Royal Astronomer of Great Britain, Cambridge +University, author of Before the Beginning + +Jeremy Rifkin, Foundation for Economic Trends +David Riquier, MIT Media Lab +Jane Rissler, Union of Concerned Scientists +Steven Rosenberg, National Institutes of Health + + Oliver Sacks, neurologist, Columbia University +Paul Saffo, futurist, Institute of the Future +Late Carl Sagan, Cornell University, author of Cosmos +Nick Sagan, coauthor of You Call This the Future? + +Michael H. Salamon, NASA’s Beyond Einstein program +Adam Savage, host of MythBusters + +Peter Schwartz, futurist, founder of Global Business Network + +Michael Shermer, founder of Skeptic Society and Skeptic magazine" +"Michael Shermer, founder of Skeptic Society and Skeptic magazine + +Donna Shirley, NASA Mars program + +Seth Shostak, SETI Institute + +Neil Shubin, author of Your Inner Fish + +Paul Shurch, SETI League + +Peter Singer, author of Wired for War + +Simon Singh, author of The Big Bang + +Gary Small, author of iBrain + +Paul Spudis, author of Odyssey Moon Limited + +Stephen Squyres, astronomer, Cornell University + +Paul Steinhardt, Princeton University, author of Endless Universe + +Jack Stern, stem cell surgeon + +Gregory Stock, UCLA, author of Redesigning Humans +Richard Stone, author of NEOs and Tunguska +Brian Sullivan, Hayden Planetarium +Leonard Susskind, physicist, Stanford University +Daniel Tammet, author of Bom on a Blue Day +Geoffrey Taylor, physicist, University of Melbourne +Late Ted Taylor, designer of U.S. nuclear warheads +Max Tegmark, cosmologist, MIT +Alvin Toffler, author of The Third Wave +Patrick Tucker, World Future Society" +"Chris Turney, University of Wollongong, author of Ice, Mud and Blood +Neil de Grasse Tyson, director of Hayden Planetarium +Sesh Velamoor, Foundation for the Future + + Robert Wallace, author of Spycraft + +Kevin Warwick, human cyborgs, University of Reading, UK +Fred Watson, astronomer, author of Stargazer +Late Mark Weiser, Xerox PARC +Alan Weisman, author of The World Without Us + +Daniel Wertheimer, SETI at Home, University of California at Berkeley +Mike Wessler, MIT AI Lab + +Roger Wiens, astronomer, Los Alamos National Laboratory +Author Wiggins, author of The Joy of Physics + +Anthony Wynshaw-Boris, National Institutes of Health +Carl Zimmer, biologist, author of Evolution +Robert Zimmerman, author of Leaving Earth +Robert Zubrin, founder of Mars Society" +"I would also like to thank my agent, Stuart Krichevsky, who has been +at my side all these years and has given me helpful advice about my +books. I have always benefited from his sound judgment. In addition, I +would like to thank my editors, Edward Kastenmeier and Melissa +Danaczko, who have guided my book and provided invaluable editorial +advice. And I would like to thank Dr. Michelle Kaku, my daughter and a +neurology resident at Mount Sinai Hospital in New York, for stimulating, +thoughtful, and fruitful discussions about the future of neurology. Her +careful and thorough reading of the manuscript has greatly enhanced the +presentation and content of this book. + +INTRODUCTION" +"INTRODUCTION + +The two greatest mysteries in all of nature are the mind and the +universe. With our vast technology, we have been able to photograph +galaxies billions of light-years away, manipulate the genes that control +life, and probe the inner sanctum of the atom, but the mind and the +universe still elude and tantalize us. They are the most mysterious and +fascinating frontiers known to science. + +If you want to appreciate the majesty of the universe, just turn your +gaze to the heavens at night, ablaze with billions of stars. Ever since our +ancestors first gasped at the splendor of the starry sky, we have puzzled +over these eternal questions: Where did it all come from? What does it +all mean?" +"To witness the mystery of our mind, all we have to do is stare at +ourselves in the mirror and wonder, What lurks behind our eyes? This +raises haunting questions like: Do we have a soul? What happens to us +after we die? Who am “I” anyway? And most important, this brings us to +the ultimate question: Where do we fit into this great cosmic scheme? As +the great Victorian biologist Thomas Huxley once said, “The question of +all questions for humanity, the problem which lies behind all others and +is more interesting than any of them, is that of the determination of +man’s place in Nature and his relation to the Cosmos.”" +"There are 100 billion stars in the Milky Way galaxy, roughly the same +as the number of neurons in our brain. You may have to travel twenty- +four trillion miles, to the first star outside our solar system, to find an +object as complex as what is sitting on your shoulders. The mind and the +universe pose the greatest scientific challenge of all, but they also share +a curious relationship. On one hand they are polar opposites. One is +concerned with the vastness of outer space, where we encounter strange +denizens like black holes, exploding stars, and colliding galaxies. The +other is concerned with inner space, where we find our most intimate +and private hopes and desires. The mind is no farther than our next + +thought, yet we are often clueless when asked to articulate and explain +it." +"thought, yet we are often clueless when asked to articulate and explain +it. + +But although they may be opposites in this respect, they also have a +common history and narrative. Both were shrouded in superstition and +magic since time immemorial. Astrologers and phrenologists claimed to +find the meaning of the universe in every constellation of the zodiac and +in every bump on your head. Meanwhile, mind readers and seers have +been alternately celebrated and vilified over the years." +"The universe and the mind continue to intersect in a variety of ways, +thanks in no small part to some of the eye-opening ideas we often +encounter in science fiction. Reading these books as a child, I would +daydream about being a member of the Sian, a race of telepaths created +by A. E. van Vogt. I marveled at how a mutant called the Mule could +unleash his vast telepathic powers and nearly seize control of the +Galactic Empire in Isaac Asimov’s Foundation Trilogy. And in the movie +Forbidden Planet, I wondered how an advanced civilization millions of +years beyond ours could channel its enormous telekinetic powers to +reshape reality to its whims and wishes." +"Then when I was about ten, “The Amazing Dunninger” appeared on +TV. He would dazzle his audience with his spectacular magic tricks. His +motto was “For those who believe, no explanation is necessary; for those +who do not believe, no explanation will suffice.” One day, he declared +that he would send his thoughts to millions of people throughout the + + country. He closed his eyes and began to concentrate, stating that he was +beaming the name of a president of the United States. He asked people +to write down the name that popped into their heads on a postcard and +mail it in. The next week, he announced triumphantly that thousands of +postcards had come pouring in with the name “Roosevelt,” the very +same name he was “beaming” across the United States." +"I wasn’t impressed. Back then, the legacy of Roosevelt was strong +among those who had lived through the Depression and World War II, so +this came as no surprise. (I thought to myself that it would have been +truly amazing if he had been thinking of President Millard Fillmore.) + +Still, it stoked my imagination, and I couldn’t resist experimenting +with telepathy on my own, trying to read other people’s minds by +concentrating as hard as I could. Closing my eyes and focusing intently, I +would attempt to “listen” to other people’s thoughts and telekinetically + +move objects around my room. + +I failed." +"move objects around my room. + +I failed. + +Maybe somewhere telepaths walked the Earth, but I wasn’t one of +them. In the process, I began to realize that the wondrous exploits of +telepaths were probably impossible—at least without outside assistance. +But in the years that followed, I also slowly learned another lesson: to +fathom the greatest secrets in the universe, one did not need telepathic +or superhuman abilities. One just had to have an open, determined, and +curious mind. In particular, in order to understand whether the fantastic +devices of science fiction are possible, you have to immerse yourself in +advanced physics. To understand the precise point when the possible +becomes the impossible, you have to appreciate and understand the laws +of physics." +"These two passions have fired up my imagination all these years: to +understand the fundamental laws of physics, and to see how science will +shape the future of our lives. To illustrate this and to share my +excitement in probing the ultimate laws of physics, I have written the +books Hyperspace , Beyond Einstein, and Parallel Worlds. And to express +my fascination with the future, I have written Visions, Physics of the +Impossible, and Physics of the Future. Over the course of writing and +researching these books, I was continually reminded that the human +mind is still one of the greatest and most mysterious forces in the world. + +Indeed, we’ve been at a loss to understand what it is or how it works +for most of history. The ancient Egyptians, for all their glorious +accomplishments in the arts and sciences, believed the brain to be a +useless organ and threw it away when embalming their pharaohs." +"Aristotle was convinced that the soul resided in the heart, not the brain, +whose only function was to cool down the cardiovascular system. +Others, like Descartes, thought that the soul entered the body through +the tiny pineal gland of the brain. But in the absence of any solid +evidence, none of these theories could be proven. + +This “dark age” persisted for thousands of years, and with good +reason. The brain weighs only three pounds, yet it is the most complex +object in the solar system. Although it occupies only 2 percent of the +body’s weight, the brain has a ravenous appetite, consuming fully 20 +percent of our total energy (in newborns, the brain consumes an +astonishing 65 percent of the baby’s energy), while fully 80 percent of + +our genes are coded for the brain. There are an estimated 100 billion +neurons residing inside the skull with an exponential amount of neural +connections and pathways." +"Back in 1977, when the astronomer Carl Sagan wrote his Pulitzer +Prize-winning book, The Dragons of Eden, he broadly summarized what +was known about the brain up to that time. His book was beautifully +written and tried to represent the state of the art in neuroscience, which +at that time relied heavily on three main sources. The first was +comparing our brains with those of other species. This was tedious and +difficult because it involved dissecting the brains of thousands of +animals. The second method was equally indirect: analyzing victims of +strokes and disease, who often exhibit bizarre behavior because of their +illness. Only an autopsy performed after their death could reveal which +part of the brain was malfunctioning. Third, scientists could use +electrodes to probe the brain and slowly and painfully piece together +which part of the brain influenced which behavior." +"But the basic tools of neuroscience did not provide a systematic way of +analyzing the brain. You could not simply requisition a stroke victim +with damage in the specific area you wanted to study. Since the brain is +a living, dynamic system, autopsies often did not uncover the most +interesting features, such as how the parts of the brain interact, let alone +how they produced such diverse thoughts as love, hate, jealousy, and +curiosity. + +TWIN REVOLUTIONS + +Four hundred years ago, the telescope was invented, and almost +overnight, this new, miraculous instrument peered into the heart of the +celestial bodies. It was one of the most revolutionary (and seditious) +instruments of all time. All of a sudden, with your own two eyes, you" +"could see the myths and dogma of the past evaporate like the morning +mist. Instead of being perfect examples of divine wisdom, the moon had +jagged craters, the sun had black spots, Jupiter had moons, Venus had +phases, and Saturn had rings. More was learned about the universe in +the fifteen years after the invention of the telescope than in all human +history put together. + +Like the invention of the telescope, the introduction of MRI machines +and a variety of advanced brain scans in the mid-1990s and 2000s has +transformed neuroscience. We have learned more about the brain in the +last fifteen years than in all prior human history, and the mind, once +considered out of reach, is finally assuming center stage." +"Nobel laureate Eric R. Kandel of the Max Planck Institute in Tubingen, +Germany, writes, “The most valuable insights into the human mind to +emerge during this period did not come from the disciplines traditionally +concerned with the mind—philosophy, psychology, or psycho-analysis. +Instead they came from a merger of these disciplines with the biology of +the brain....” + +Physicists have played a pivotal role in this endeavor, providing a +flood of new tools with acronyms like MRI, EEG, PET, CAT, TCM, TES, +and DBS that have dramatically changed the study of the brain. +Suddenly with these machines we could see thoughts moving within the +living, thinking brain. As neurologist V. S. Ramachandran of the +University of California, San Diego, says, “All of these questions that +philosophers have been studying for millennia, we scientists can begin to +explore by doing brain imaging and by studying patients and asking the +right questions.”" +"Looking back, some of my initial forays into the world of physics +intersected with the very technologies that are now opening up the mind +for science. In high school, for instance, I became aware of a new form +of matter, called antimatter, and decided to conduct a science project on +the topic. As it is one of the most exotic substances on Earth, I had to +appeal to the old Atomic Energy Commission just to obtain a tiny +quantity of sodium-22, a substance that naturally emits a positive +electron (anti-electron, or positron). With my small sample in hand, I +was able to build a cloud chamber and powerful magnetic field that +allowed me to photograph the trails of vapor left by antimatter particles. +I didn’t know it at the time, but sodium-22 would soon become +instrumental in a new technology, called PET (positron emission +tomography), which has since given us startling new insights into the +thinking brain." +"Yet another technology I experimented with in high school was +magnetic resonance. I attended a lecture by Felix Bloch of Stanford + + University, who shared the 1952 Nobel Prize for Physics with Edward + +Purcell for the discovery of nuclear magnetic resonance. Dr. Bloch +explained to us high school kids that if you had a powerful magnetic +field, the atoms would align vertically in that field like compass needles. +Then if you applied a radio pulse to these atoms at a precise resonant +frequency, you could make them flip over. When they eventually flipped +back, they would emit another pulse, like an echo, which would allow +you to determine the identity of these atoms. (Later, I used the principle +of magnetic resonance to build a 2.3-million-electron-volt particle +accelerator in my mom’s garage.)" +"Just a couple of years later, as a freshman at Harvard University, it +was an honor to have Dr. Purcell teach me electrodynamics. Around that +same time, I also had a summer job and got a chance to work with Dr. +Richard Ernst, who was trying to generalize the work of Bloch and +Purcell on magnetic resonance. He succeeded spectacularly and would +eventually win the Nobel Prize for Physics in 1991 for laying the +foundation for the modern MRI (magnetic resonance imaging) machine. +The MRI machine, in turn, has given us detailed photographs of the +living brain in even finer detail than PET scans. + +EMPOWERING THE MIND" +"EMPOWERING THE MIND + +Eventually I became a professor of theoretical physics, but my +fascination with the mind remained. It is thrilling to see that, just within +the last decade, advances in physics have made possible some of the +feats of mentalism that excited me when I was a child. Using MRI scans, +scientists can now read thoughts circulating in our brains. Scientists can +also insert a chip into the brain of a patient who is totally paralyzed and +connect it to a computer, so that through thought alone that patient can +surf the web, read and write e-mails, play video games, control their +wheelchair, operate household appliances, and manipulate mechanical +arms. In fact, such patients can do anything a normal person can do via +a computer." +"Scientists are now going even further, by connecting the brain directly +to an exoskeleton that these patients can wear around their paralyzed +limbs. Quadriplegics may one day lead near-normal lives. Such +exoskeletons may also give us superpowers enabling us to handle deadly + +emergencies. One day, our astronauts may even explore the planets by +mentally controlling mechanical surrogates from the comfort of their + + living rooms." +"living rooms. + +As in the movie The Matrix, we might one day be able to download +memories and skills using computers. In animal studies, scientists have +already been able to insert memories into the brain. Perhaps it’s only a +matter of time before we, too, can insert artificial memories into our +brains to learn new subjects, vacation in new places, and master new +hobbies. And if technical skills can be downloaded into the minds of +workers and scientists, this may even affect the world economy. We +might even be able to share these memories as well. One day, scientists +might construct an “Internet of the mind,” or a brain-net, where +thoughts and emotions are sent electronically around the world. Even +dreams will be videotaped and then “brain-mailed” across the Internet." +"Technology may also give us the power to enhance our intelligence. +Progress has been made in understanding the extraordinary powers of +“savants” whose mental, artistic, and mathematical abilities are truly +astonishing. Furthermore, the genes that separate us from the apes are +now being sequenced, giving us an unparalleled glimpse into the +evolutionary origins of the brain. Genes have already been isolated in +animals that can increase their memory and mental performance." +"The excitement and promise generated by these eye-opening advances +are so enormous that they have also caught the attention of the +politicians. In fact, brain science has suddenly become the source of a +transatlantic rivalry between the greatest economic powers on the +planet. In January 2013, both President Barack Obama and the European +Union announced what could eventually become multibillion-dollar +funding for two independent projects that would reverse engineer the +brain. Deciphering the intricate neural circuitry of the brain, once +considered hopelessly beyond the scope of modern science, is now the +focus of two crash projects that, like the Human Genome Project, will +change the scientific and medical landscape. Not only will this give us +unparalleled insight into the mind, it will also generate new industries, +spur economic activity, and open up new vistas for neuroscience." +"Once the neural pathways of the brain are finally decoded, one can +envision understanding the precise origins of mental illness, perhaps +leading to a cure for this ancient affliction. This decoding also makes it + +possible to create a copy of the brain, which raises philosophical and +ethical questions. Who are we, if our consciousness can be uploaded into +a computer? We can also toy with the concept of immortality. Our +bodies may eventually decay and die, but can our consciousness live +forever? + +And beyond that, perhaps one day in the distant future the mind will + + be freed of its bodily constraints and roam among the stars, as several +scientists have speculated. Centuries from now, one can imagine placing +our entire neural blueprint on laser beams, which will then be sent into +deep space, perhaps the most convenient way for our consciousness to +explore the stars." +"A brilliant new scientific landscape that will reshape human destiny is +now truly opening up. We are now entering a new golden age of +neuroscience. + +In making these predictions, I have had the invaluable assistance of +scientists who graciously allowed me to interview them, broadcast their +ideas on national radio, and even take a TV crew into their laboratories. +These are the scientists who are laying the foundation for the future of +the mind. For their ideas to be incorporated into this book, I made only +two requirements: (1) their predictions must rigorously obey the laws of +physics; and (2) prototypes must exist to show proof-of-principle for +these far-reaching ideas. + +TOUCHED BY MENTAL ILLN ESS" +"TOUCHED BY MENTAL ILLN ESS + +I once wrote a biography of Albert Einstein, called Einstein’s Cosmos, and +had to delve into the minute details of his private life. I had known that +Einstein’s youngest son was afflicted with schizophrenia, but did not +realize the enormous emotional toll that it had taken on the great +scientist’s life. Einstein was also touched by mental illness in another +way; one of his closest colleagues was the physicist Paul Ehrenfest, who +helped Einstein create the theory of general relativity. After suffering +bouts of depression, Ehrenfest tragically killed his own son, who had +Down’s syndrome, and then committed suicide. Over the years, I have +found that many of my colleagues and friends have struggled to manage +mental illness in their families." +"Mental illness has also deeply touched my own life. Several years ago, +my mother died after a long battle with Alzheimer’s disease. It was +heartbreaking to see her gradually lose her memories of her loved ones, +to gaze into her eyes and realize that she did not know who I was. I +could see the glimmer of humanity slowly being extinguished. She had +spent a lifetime struggling to raise a family, and instead of enjoying her +golden years, she was robbed of all the memories she held dear. + +As the baby boomers age, the sad experience that I and many others +have had will be repeated across the world. My wish is that rapid +advances in neuroscience will one day alleviate the suffering felt by +those afflicted with mental illness and dementia. + + WHAT IS DRIVING THIS REVOLUTION?" +"WHAT IS DRIVING THIS REVOLUTION? + +The data pouring in from brain scans are now being decoded, and the +progress is stunning. Several times a year, headlines herald a fresh +breakthrough. It took 350 years, since the invention of the telescope, to +enter the space age, but it has taken only fifteen years since the +introduction of the MRI and advanced brain scans to actively connect +the brain to the outside world. Why so quickly , and how much is there to +come?" +"Part of this rapid progress has occurred because physicists today have +a good understanding of electromagnetism, which governs the electrical +signals racing through our neurons. The mathematical equations of +James Clerk Maxwell, which are used to calculate the physics of +antennas, radar, radio receivers, and microwave towers, form the very +cornerstone of MRI technology. It took centuries to finally solve the +secret of electromagnetism, but neuroscience can enjoy the fruits of this +grand endeavor. In Book I, I will survey the history of the brain and +explain how a galaxy of new instruments has left the physics labs and +given us glorious color pictures of the mechanics of thought. Because +consciousness plays so central a role in any discussion of the mind, I also +give a physicist’s perspective, offering a definition of consciousness that +includes the animal kingdom as well. In fact, I provide a ranking of +consciousness, showing how it is possible to assign a number to various" +"consciousness, showing how it is possible to assign a number to various +types of consciousness." +"But to fully answer the question of how this technology will advance, +we also have to look at Moore’s law, which states that computer power +doubles every two years. I often surprise people with the simple fact that +your cell phone today has more computer power than all of NASA when +it put two men on the moon in 1969. Computers are now powerful +enough to record the electrical signals emanating from the brain and +partially decode them into a familiar digital language. This makes it +possible for the brain to directly interface with computers to control any +object around it. The fast-growing field is called BMI (brain-machine +interface), and the key technology is the computer. In Book II, I’ll +explore this new technology, which has made recording memories, mind +reading, videotaping our dreams, and telekinesis possible." +"In Book III, I’ll investigate alternate forms of consciousness, from +dreams, drugs, and mental illness to robots and even aliens from outer +space. Here we’ll also learn about the potential to control and +manipulate the brain to manage diseases such as depression, Parkinson’s, +Alzheimer’s, and many more. I will also elaborate on the Brain Research +Through Advancing Innovative Neurotechnologies (or BRAIN) project + + announced by President Obama, and the Human Brain Project of the +European Union, which will potentially allocate billions of dollars to +decode the pathways of the brain, all the way down to the neural level. +These two crash programs will undoubtedly open up entirely new +research areas, giving us new ways to treat mental illness and also +revealing the deepest secrets of consciousness." +"After we have given a definition of consciousness, we can use it to +explore nonhuman consciousness as well (i.e., the consciousness of +robots). How advanced can robots become? Can they have emotions? +Will they pose a threat? And we can also explore the consciousness of +aliens, who may have goals totally different from ours. + +In the Appendix, I will discuss perhaps the strangest idea in all of +science, the concept from quantum physics that consciousness may be +the fundamental basis for reality. + +There is no shortage of proposals for this exploding field. Only time +will tell which ones are mere pipe dreams created by the overheated +imagination of science-fiction writers and which ones represent solid +avenues for future scientific research. Progress in neuroscience has been +astronomical, and in many ways the key has been modern physics, + +which uses the full power of the electromagnetic and nuclear forces to +probe the great secrets hidden within our minds." +"I should stress that I am not a neuroscientist. I am a theoretical +physicist with an enduring interest in the mind. I hope that the vantage +point of a physicist can help further enrich our knowledge and give a +fresh new understanding of the most familiar and alien object in the +universe: our mind. + +But given the dizzying pace with which radically new perspectives are +being developed, it is important that we have a firm grasp on how the +brain is put together. + +So let us first discuss the origins of modern neuroscience, which some +historians believe began when an iron spike sailed through the brain of a +certain Phineas Gage. This seminal event set off a chain reaction that +helped open the brain to serious scientific investigation. Although it was +an unfortunate event for Mr. Gage, it paved the way for modern science. + +BOOK I THE MIND AND CONSCIOUSNESS + +My fundamental premise about the brain is that its workings—" +"BOOK I THE MIND AND CONSCIOUSNESS + +My fundamental premise about the brain is that its workings— + + what we sometimes call “mind”—are a consequence of its +anatomy and physiology, and nothing more. + +—CARL SAGAN + +1 UNLOCKING THE MIND + +In 1848, Phineas Gage was working as a railroad foreman in Vermont, +when dynamite accidentally went off, propelling a three-foot, seven-inch +spike straight into his face, through the front part of his brain, and out +the top of his skull, eventually landing eighty feet away. His fellow +workers, shocked to see part of their foreman’s brain blown off, +immediately called for a doctor. To the workers’ (and even the doctor’s) +amazement, Mr. Gage did not die on-site." +"He was semiconscious for weeks, but eventually made what seemed +like a full recovery. (A rare photograph of Gage surfaced in 2009, +showing a handsome, confident man, with an injury to his head and left +eye, holding the iron rod.) But after this incident, his coworkers began to +notice a sharp change in his personality. A normally cheerful, helpful +foreman, Gage became abusive, hostile, and selfish. Ladies were warned +to stay clear of him. Dr. John Harlow, the doctor who treated him, +observed that Gage was “capricious and vacillating, devising many plans +of future operations, which are no sooner arranged than they are +abandoned in turn for others appearing more feasible. A child in his +intellectual capacity and manifestations, yet with the animal passions of +a strong man.” Dr. Harlow noted that he was “radically changed” and +that his fellow workers said that “he was no longer Gage.” After Gage’s +death in 1860, Dr. Harlow preserved both his skull and the rod that had" +"death in 1860, Dr. Harlow preserved both his skull and the rod that had +smashed into it. Detailed X-ray scans of the skull have since confirmed +that the iron rod caused massive destruction in the area of the brain +behind the forehead known as the frontal lobe, in both the left and right +cerebral hemispheres." +"This incredible accident would not only change the life of Phineas +Gage, it would alter the course of science as well. Previously, the +dominant thinking was that the brain and the soul were two separate +entities, a philosophy called dualism. But it became increasingly clear +that damage to the frontal lobe of his brain had caused abrupt changes + +in Gage’s personality. This, in turn, created a paradigm shift in scientific +thinking: perhaps specific areas of the brain could be traced to certain +behaviors. + + broca’s brain" +"broca’s brain + +In 1861, just a year after Gage’s death, this view was further cemented +through the work of Pierre Paul Broca, a physician in Paris who +documented a patient who appeared normal except that he had a severe +speech deficit. The patient could understand and comprehend speech +perfectly, but he could utter only one sound, the word “tan.” After the +patient died, Dr. Broca confirmed during the autopsy that the patient +suffered from a lesion in his left temporal lobe, a region of the brain near +his left ear. Dr. Broca would later confirm twelve similar cases of +patients with damage to this specific area of the brain. Today patients +who have damage to the temporal lobe, usually in the left hemisphere, +are said to suffer from Broca’s aphasia. (In general, patients with this +disorder can understand speech but cannot say anything, or else they +drop many words when speaking.)" +"Soon afterward, in 1874, German physician Carl Wernicke described +patients who suffered from the opposite problem. They could articulate +clearly, but they could not understand written or spoken speech. Often +these patients could speak fluently with correct grammar and syntax, but +with nonsensical words and meaningless jargon. Sadly, these patients +often didn’t know they were spouting gibberish. Wernicke confirmed +after performing autopsies that these patients had suffered damage to a +slightly different area of the left temporal lobe. + +The works of Broca and Wernicke were landmark studies in +neuroscience, establishing a clear link between behavioral problems, +such as speech and language impairment, and damage to specific regions +of the brain." +"Another breakthrough took place amid the chaos of war. Throughout +history, there were many religious taboos prohibiting the dissection of +the human body, which severely restricted progress in medicine. In +warfare, however, with tens of thousands of bleeding soldiers dying on +the battlefield, it became an urgent mission for doctors to develop any + +medical treatment that worked. During the Prusso-Danish War in 1864, +German doctor Gustav Fritsch treated many soldiers with gaping wounds +to the brain and happened to notice that when he touched one +hemisphere of the brain, the opposite side of the body often twitched. +Later Fritsch systematically showed that, when he electrically stimulated +the brain, the left hemisphere controlled the right side of the body, and +vice versa. This was a stunning discovery, demonstrating that the brain +was basically electrical in nature and that a particular region of the +brain controlled a part on the other side of the body. (Curiously, the use" +"of electrical probes on the brain was first recorded a couple of thousand +years earlier by the Romans. In the year A.D. 43, records show that the +court doctor to the emperor Claudius used electrically charged torpedo +fish, which were applied to the head of a patient suffering from severe +headaches.) + +The realization that there were electrical pathways connecting the +brain to the body wasn’t systematically analyzed until the 1930s, when +Dr. Wilder Penfield began working with epilepsy patients, who often +suffered from debilitating convulsions and seizures that were potentially +life-threatening. For them, the last option was to have brain surgery, +which involved removing parts of the skull and exposing the brain. +(Since the brain has no pain sensors, a person can be conscious during +this entire procedure, so Dr. Penfield used only a local anesthetic during +the operation.)" +"Dr. Penfield noticed that when he stimulated certain parts of the +cortex with an electrode, different parts of the body would respond. He +suddenly realized that he could draw a rough one-to-one correspondence +between specific regions of the cortex and the human body. His +drawings were so accurate that they are still used today in almost +unaltered form. They had an immediate impact on both the scientific +community and the general public. In one diagram, you could see which +region of the brain roughly controlled which function, and how +important each function was. For example, because our hands and +mouth are so vital for survival, a considerable amount of brain power is +devoted to controlling them, while the sensors in our back hardly +register at all. + +Furthermore, Penfield found that by stimulating parts of the temporal +lobe, his patients suddenly relived long-forgotten memories in a crystal-" +"clear fashion. He was shocked when a patient, in the middle of brain +surgery, suddenly blurted out, “It was like ... standing in the doorway at +[my] high school.... I heard my mother talking on the phone, telling my +aunt to come over that night.” Penfield realized that he was tapping into +memories buried deep inside the brain. When he published his results in +1951, they created another transformation in our understanding of the +brain. + +Figure 1. This is the map of the motor cortex that was created by Dr. Wilder Penfield, showing which +region of the brain + +controls which part of the body, (illustration credit 1.1) + + A MAP OF THE BRAIN + +By the 1950s and ’60s, it was possible to create a crude map of the brain, +locating different regions and even identifying the functions of a few of +them." +"In Figure 2, we see the neocortex, which is the outer layer of the +brain, divided into four lobes. It is highly developed in humans. All the +lobes of the brain are devoted to processing signals from our senses, +except for one: the frontal lobe, located behind the forehead. The +prefrontal cortex, the foremost part of the frontal lobe, is where most +rational thought is processed. The information you are reading right now +is being processed in your prefrontal cortex. Damage to this area can +impair your ability to plan or contemplate the future, as in the case of +Phineas Gage. This is the region where information from our senses is +evaluated and a future course of action is carried out. + +FRONTAL +LOBE + +PARIETAL +LOBE + +OCCIPITAL + +LOBE + +TEMPORAL + +LOBE + + Figure 2. The four lobes of the neocortex of the brain are responsible for different, though related, +functions, (illustration + +credit 1.2)" +"credit 1.2) + +The parietal lobe is located at the top of our brains. The right +hemisphere controls sensory attention and body image; the left +hemisphere controls skilled movements and some aspects of language. +Damage to this area can cause many problems, such as difficulty in +locating parts of your own body. + +The occipital lobe is located at the very back of the brain and +processes visual information from the eyes. Damage to this area can +cause blindness and visual impairment. + +The temporal lobe controls language (on the left side only), as well as +the visual recognition of faces and certain emotional feelings. Damage to +this lobe can leave us speechless or without the ability to recognize +familiar faces. + +THE EVOLVING BRAIN" +"THE EVOLVING BRAIN + +When you look at other organs of the body, such as our muscles, bones, +and lungs, there seems to be an obvious rhyme and reason to them that +we can immediately see. But the structure of the brain might seem +slapped together in a rather chaotic fashion. In fact, trying to map the +brain has often been called “cartography for fools.”" +"To make sense of the seemingly random structure of the brain, in 1967 +Dr. Paul MacLean of the National Institute of Mental Health applied +Charles Darwin’s theory of evolution to the brain. He divided the brain +into three parts. (Since then, studies have shown that there are +refinements to this model, but we will use it as a rough organizing +principle to explain the overall structure of the brain.) First, he noticed +that the back and center part of our brains, containing the brain stem, +cerebellum, and basal ganglia, are almost identical to the brains of +reptiles. Known as the “reptilian brain,” these are the oldest structures of +the brain, governing basic animal functions such as balance, breathing, +digestion, heartbeat, and blood pressure. They also control behaviors +such as fighting, hunting, mating, and territoriality, which are necessary +for survival and reproduction. The reptilian brain can be traced back +about 500 million years. (See Figure 3.)" +"But as we evolved from reptiles to mammals, the brain also became +more complex, evolving outward and creating entirely new structures. + + Here we encounter the “mammalian brain,” or the limbic system, which +is located near the center of the brain, surrounding parts of the reptilian +brain. The limbic system is prominent among animals living in social +groups, such as the apes. It also contains structures that are involved in +emotions. Since the dynamics of social groups can be quite complex, the +limbic system is essential in sorting out potential enemies, allies, and +rivals. + +HUMAN + +BRAIN + +Hypothalamus + +MAMMALIAN +L BRAIN . + +REPTILIAN + +BRAIN + +Corpus callosum + +Cingulate gyrus + +Frontal lobe + +Hippocampus + +Forn + +Cerebellum + +Brain stem + +Pituitary + + gland" +"Frontal lobe + +Hippocampus + +Forn + +Cerebellum + +Brain stem + +Pituitary + + gland + +Figure 3. The evolutionary history of the brain, with the reptilian brain, the limbic system (the +mammalian brain), and the +neocortex (the human brain). Roughly speaking, one can argue that the path of our brain’s evolution +passed from the +reptilian brain to the mammalian brain to the human brain, (illustration credit 1.3) + +The different parts of the limbic system that control behaviors crucial +for social animals are: + +• The hippocampus. This is the gateway to memory, where short-term +memories are processed into long-term memories. Its name means +“seahorse,” which describes its strange shape. Damage here will +destroy the ability to make new long-term memories. You are left a +prisoner of the present. + +• The amygdala. This is the seat of emotions, especially fear, where +emotions are first registered and generated. Its name means +“almond.”" +"• The thalamus. This is like a relay station, gathering sensory signals +from the brain stem and then sending them out to the various +cortices. Its name means “inner chamber.” + +• The hypothalamus. This regulates body temperature, our circadian +rhythm, hunger, thirst, and aspects of reproduction and pleasure. It +lies below the thalamus—hence its name. + +Finally, we have the third and most recent region of the mammalian +brain, the cerebral cortex, which is the outer layer of the brain. The +latest evolutionary structure within the cerebral cortex is the neocortex +(meaning “new bark”), which governs higher cognitive behavior. It is +most highly developed in humans: it makes up 80 percent of our brain’s +mass, yet is only as thick as a napkin. In rats the neocortex is smooth, +but it is highly convoluted in humans, which allows a large amount of +surface area to be crammed into the human skull." +"In some sense, the human brain is like a museum containing remnants +of all the previous stages in our evolution over millions of years, +exploding outward and forward in size and function. (This is also +roughly the path taken when an infant is born. The infant brain expands +outward and toward the front, perhaps mimicking the stages of our +evolution.) + +Although the neocortex seems unassuming, looks are deceiving. Under +a microscope you can appreciate the intricate architecture of the brain. +The gray matter of the brain consists of billions of tiny brain cells called +neurons. Like a gigantic telephone network, they receive messages from +other neurons via dendrites, which are like tendrils sprouting from one +end of the neuron. At the other end of the neuron, there is a long fiber +called the axon. Eventually the axon connects to as many as ten" +"thousand other neurons via their dendrites. At the juncture between the +two, there is a tiny gap called the synapse. These synapses act like gates, +regulating the flow of information within the brain. Special chemicals +called neurotransmitters can enter the synapse and alter the flow of +signals. Because neurotransmitters like dopamine, serotonin, and +noradrenaline help control the stream of information moving across the +myriad pathways of the brain, they exert a powerful effect on our +moods, emotions, thoughts, and state of mind. (See Figure 4.) + +This description of the brain roughly represented the state of +knowledge through the 1980s. In the 1990s, however, with the +introduction of new technologies from the field of physics, the +mechanics of thought began to be revealed in exquisite detail, +unleashing the current explosion of scientific discovery. One of the +workhorses of this revolution has been the MRI machine." +"Figure 4. Diagram of a neuron. Electrical signals travel along the axon of the neuron until they hit the +synapse. +Neurotransmitters can regulate the flow of electrical signals past the synapse, (illustration credit 1.4) + +THE MRI: WINDOW INTO THE BRAIN + +To understand the reason why this radical new technology has helped +decode the thinking brain, we have to turn our attention to some basic +principles of physics. + +Radio waves, a type of electromagnetic radiation, can pass right + + through tissue without doing damage. MRI machines take advantage of +this fact, allowing electromagnetic waves to freely penetrate the skull. In +the process, this technology has given us glorious photographs of +something once thought to be impossible to capture: the inner workings + +of the brain as it experiences sensations and emotions. Watching the +dance of lights flickering in a MRI machine, one can trace out the +thoughts moving within the brain. It’s like being able to see the inside of +a clock as it ticks." +"The first thing you notice about an MRI machine is the huge, +cylindrical magnetic coils, which can produce a magnetic field twenty to +sixty thousand times greater than the strength of Earth’s. The giant +magnet is one of the principal reasons why an MRI machine can weigh a +ton, fill up an entire room, and cost several million dollars. (MRI +machines are safer than X-ray machines because they don’t create +harmful ions. CT scans, which can also create 3-D pictures, flood the +body with many times the dosage from an ordinary X-ray, and hence +have to be carefully regulated. By contrast, MRI machines are safe when +used properly. One problem, however, is the carelessness of workers. +The magnetic field is powerful enough to send tools hurling through the +air at high velocity when turned on at the wrong time. People have been +injured and even killed in this way.)" +"MRI machines work as follows: Patients lie flat and are inserted into a +cylinder containing two large coils, which create the magnetic field. +When the magnetic field is turned on, the nuclei of the atoms inside your +body act very much like a compass needle: they align horizontally along +the direction of the field. Then a small pulse of radio energy is +generated, which causes some of the nuclei in our body to flip upside +down. When the nuclei later revert back to their normal position, they +emit a secondary pulse of radio energy, which is then analyzed by the +MRI machine. By analyzing these tiny “echoes,” one can then reconstruct +the location and nature of these atoms. Like a bat, which uses echoes to +determine the position of objects in its path, the echoes created by the +MRI machine allow scientists to re-create a remarkable image of the +inside of the brain. Computers then reconstruct the position of the +atoms, giving us beautiful diagrams in three dimensions." +"When MRIs were originally introduced, they were able to show the +static structure of the brain and its various regions. However, in the mid- +1990s, a new type of MRI was invented, called “functional” MRI, or +fMRI, which detected the presence of oxygen in the blood in the brain. +(For different types of MRI machines, scientists sometimes put a +lowercase letter in front of “MRI,” but we will use the abbreviation MRI + + to denote all the various types of MRI machines.) MRI scans cannot +directly detect the flow of electricity in the neurons, but since oxygen is +necessary to provide the energy for the neurons, oxygenated blood can +indirectly trace the flow of electrical energy in the neurons and show +how various regions of the brain interact with one another." +"Already these MRI scans have definitively disproven the idea that +thinking is concentrated in a single center. Instead, one can see electrical +energy circulating across different parts of the brain as it thinks. By +tracing the path taken by our thoughts, MRI scans have shed new light +into the nature of Alzheimer’s, Parkinson’s, schizophrenia, and a host of +other mental diseases. + +The great advantage of MRI machines is their exquisite ability to +locate minute parts of the brain, down to a fraction of a millimeter in +size. An MRI scan will create not just dots on a two-dimensional screen, +called pixels, but dots in three-dimensional space, called “voxels,” +yielding a bright collection of tens of thousands of colored dots in 3-D, in +the shape of a brain." +"Since different chemical elements respond to different frequencies of +radio, you can change the frequency of the radio pulse and therefore +identify different elements of the body. As noted, fMRI machines zero in +on the oxygen atom contained within blood in order to measure blood +flow, but MRI machines can also be tuned to identify other atoms. In just +the last decade, a new form of MRI was introduced called “diffusion +tensor imaging” MRI, which detects the flow of water in the brain. Since +water follows the neural pathways of the brain, DTI yields beautiful +pictures that resemble networks of vines growing in a garden. Scientists +can now instantly determine how certain parts of the brain are hooked +up with other parts." +"There are a couple of drawbacks to MRI technology, however. +Although they are unparalleled in spatial resolution, locating voxels +down to the size of a pinpoint in three dimensions, MRIs are not that +good in temporal resolution. It takes almost a full second to follow the +path of blood in the brain, which may not sound like a lot, but +remember that electrical signals travel almost instantly throughout the +brain, and hence MRI scans can miss some of the intricate details of +thought patterns. + +Another snag is the cost, which runs in the millions of dollars, so + +doctors often have to share the machines. But like most technology, +developments should bring down the cost over time." +"In the meantime, exorbitant costs haven’t stalled the hunt for +commercial applications. One idea is to use MRI scans as lie detectors, +which, according to some studies, can identify lies with 95 percent +accuracy or higher. The level of accuracy is still controversial, but the +basic idea is that when a person tells a lie, he simultaneously has to +know the truth, concoct the lie, and rapidly analyze the consistency of +this lie with previously known facts. Today some companies are claiming +that MRI technology shows that the prefrontal and parietal lobes light up +when someone tells a lie. More specifically, the “orbitofrontal cortex” +(which can serve, among other functions, as the brain’s “fact-checker” to +warn us when something is wrong) becomes active. This area is located +right behind the orbits of our eyes, and hence the name. The theory goes +that the orbitofrontal cortex understands the difference between the +truth and a lie and kicks into overdrive as a result. (Other areas of the" +"truth and a lie and kicks into overdrive as a result. (Other areas of the +brain also light up when someone tells a lie, such as the superiormedial +and inferolateral prefrontal cortices, which are involved in cognition.)" +"Already there are several commercial firms offering MRI machines as +lie detectors, and cases involving these machines are entering the court +system. But it’s important to note that these MRI scans indicate increased +brain activity only in certain areas. While DNA results can sometimes +have an accuracy of one part in 10 billion or better, MRI scans cannot, +because it takes many areas of the brain to concoct a lie, and these same +areas of the brain are responsible for processing other kinds of thoughts +as well. + +EEG SCANS + +Another useful tool to probe deep inside the brain is the EEG, the +electroencephalogram. The EEG was introduced all the way back in +1924, but only recently has it been possible to employ computers to +make sense out of all the data pouring in from each electrode. + +To use the EEG machine, the patient usually puts on a futuristic- +looking helmet with scores of electrodes on the surface. (More advanced +versions place a hairnet over the head containing a series of tiny" +"electrodes.) These electrodes detect the tiny electrical signals that are +circulating in the brain. + +(illustration credit 1.5) + + Figure 5. At the top, we see an image taken by a functional MRI machine, showing regions of high +mental activity. In the + +bottom image, we see the flowerlike pattern created by a diffusion MRI machine, which can follow the +neural pathways + +and connections of the brain, (illustration credit 1.5a)" +"An EEG scan differs from an MRI scan in several crucial ways. The +MRI scan, as we have seen, shoots radio pulses into the brain and then +analyzes the “echoes” that come back. This means you can vary the +radio pulse to select different atoms for analysis, making it quite +versatile. The EEG machine, however, is strictly passive; that is, it +analyzes the tiny electromagnetic signals the brain naturally emits. The +EEG excels at recording the broad electromagnetic signals that surge +across the entire brain, which allows scientists to measure the overall +activity of the brain as it sleeps, concentrates, relaxes, dreams, etc. +Different states of consciousness vibrate at different frequencies. For +example, deep sleep corresponds to delta waves, which vibrate at .1 to 4 +cycles per second. Active mental states, such as problem solving, +correspond to beta waves, vibrating from 12 to 30 cycles per second. +These vibrations allow various parts of the brain to share information" +"These vibrations allow various parts of the brain to share information +and communicate with one another, even if they are located on opposite +sides of the brain. And while MRI scans measuring blood flow can be +taken only several times a second, EEG scans measure electrical activity +instantly." +"The greatest advantage of the EEG scan, though, is its convenience +and cost. Even high school students have done experiments in their +living rooms with EEG sensors placed over their heads. + +However, the main drawback to the EEG, which has held up its +development for decades, is its very poor spatial resolution. The EEG +picks up electrical signals that have already been diffused after passing +through the skull, making it difficult to detect abnormal activity when it +originates deep in the brain. Looking at the output of the muddled EEG +signals, it is almost impossible to say for sure which part of the brain +created it. Furthermore, slight motions, like moving a finger, can distort +the signal, sometimes rendering it useless. + +PET SCANS + + Yet another useful tool from the world of physics is the positron +emission topography (PET) scan, which calculates the flow of energy in" +"the brain by locating the presence of glucose, the sugar molecule that +fuels cells. Like the cloud chamber I made as a high school student, PET +scans make use of the subatomic particles emitted from sodium-22 +within the glucose. To start the PET scan, a special solution containing +slightly radioactive sugar is injected into the patient. The sodium atoms +inside the sugar molecules have been replaced by radioactive sodium-22 +atoms. Every time a sodium atom decays, it emits a positive electron, or +positron, which is easily detected by sensors. By following the path of +the radioactive sodium atoms in sugar, one can then trace out the energy +flow within the living brain. + +The PET scan shares many of the same advantages of MRI scans but +does not have the fine spatial resolution of an MRI photo. However, +instead of measuring blood flow, which is only an indirect indicator of +energy consumption in the body, PET scans measure energy +consumption, so it is more closely related to neural activity." +"There is another drawback to PET scans, however. Unlike MRI and +EEG scans, PET scans are slightly radioactive, so patients cannot +continually take them. In general, a person is not allowed to have a PET +scan more than once a year because of the risk from radiation. + +MAGNETISM IN THE BRAIN + +Within the last decade, many new high-tech devices have entered the +tool kit of neuroscientists, including the transcranial electromagnetic +scanner (TES), magnetoencephalography (MEG), near-infrared +spectroscopy (NIRS), and optogenetics, among others." +"In particular, magnetism has been used to systematically shut down +specific parts of the brain without cutting it open. The basic physics +behind these new tools is that a rapidly changing electric field can create +a magnetic field, and vice versa. MEGs passively measure the magnetic +fields produced by the changing electric fields of the brain. These +magnetic fields are weak and extremely tiny, only a billionth of Earth’s +magnetic field. Like the EEG, the MEG is extremely good at time +resolution, down to a thousandth of a second. Its spatial resolution, +however, is only a cubic centimeter. + +Unlike the passive measurement of the MEG, the TES generates a large + + pulse of electricity, which in turn creates a burst of magnetic energy. +The TES is placed next to the brain, so the magnetic pulse penetrates the +skull and creates yet another electric pulse inside the brain. This +secondary electrical pulse, in turn, is sufficient to turn off or dampen the +activity of selected areas of the brain." +"Historically, scientists had to rely on strokes or tumors to silence +certain parts of the brain and hence determine what they do. But with +the TES, one can harmlessly turn off or dampen parts of the brain at will. +By shooting magnetic energy at a particular spot in the brain, one can +determine its function by simply watching how a person’s behavior has +changed. (For example, by shooting magnetic pulses into the left +temporal lobe, one can see that this adversely affects our ability to talk.)" +"One potential drawback of the TES is that these magnetic fields do not +penetrate very far into the interior of the brain (because magnetic fields +decrease much faster than the usual inverse square law for electricity). +TES is quite useful in turning off parts of the brain near the skull, but the +magnetic field cannot reach important centers located deep in the brain, +such as the limbic system. But future generations of TES devices may +overcome this technical problem by increasing the intensity and +precision of the magnetic field. + +Wire coil + +Pulsed magnetic field + +Stimulated +brain region + +Positioning + +frame + +Figure 6. We see the transcranial electromagnetic scanner and the magnetoencephalograph, which uses +magnetism rather +than radio waves to penetrate the skull and determine the nature of thoughts within the brain. +Magnetism can +temporarily silence parts of the brain, allowing scientists to safely determine how these regions perform +without relying" +"on stroke victims, (illustration credit 1.6) + +DEEP BRAIN STIMULATION + +Yet another tool that has proven vital to neurologists is deep brain +stimulation (DBS). The probes originally used by Dr. Penfield were +relatively crude. Today these electrodes can be hairlike and reach +specific areas of the brain deep within its interior. Not only has DBS +allowed scientists to locate the function of various parts of the brain, it +can also be used to treat mental disorders. DBS has already proven its + +worth with Parkinson’s disease, in which certain regions of the brain are +overactive and often create uncontrollable shaking of the hands. + +More recently, these electrodes have targeted a new area of the brain +(called Brodmann’s area number 25) that is often overactive in +depressed patients who do not respond to psychotherapy or drugs. Deep +brain stimulation has given almost miraculous relief after decades of +torment and agony for these long-suffering patients." +"Every year, new uses for deep brain stimulation are being found. In +fact, nearly all the major disorders of the brain are being reexamined in +light of this and other new brain-scanning technologies. This promises to +be an exciting new area for diagnosing and even treating illnesses. + +OPTOGENETICS—LIGHTING UP THE BRAIN + +But perhaps the newest and most exciting instrument in the neurologist’s +tool kit is optogenetics, which was once considered science fiction. Like +a magic wand, it allows you to activate certain pathways controlling +behavior by shining a light beam on the brain. + +Incredibly, a light-sensitive gene that causes a cell to fire can be +inserted, with surgical precision, directly into a neuron. Then, by turning +on a light beam, the neuron is activated. More importantly, this allows +scientists to excite these pathways, so that you can turn on and off +certain behaviors by flicking a switch." +"Although this technology is only a decade old, optogenetics has +already proven successful in controlling certain animal behaviors. By + + turning on a light switch, it is possible to make fruit flies suddenly fly +off, worms stop wiggling, and mice run around madly in circles. Monkey +trials are now beginning, and even human trials are in discussion. There +is great hope that this technology will have a direct application in +treating disorders like Parkinson’s and depression. + +THE TRANSPARENT BRAIN + +Like optogenetics, another spectacular new development is making the +brain fully transparent so that its neural pathways are exposed to the +naked eye. In 2013, scientists at Stanford University announced that + +they had successfully made the entire brain of a mouse transparent, as +well as parts of a human brain. The announcement was so stunning that +it made the front page of the New York Times, with the headline “Brain +as Clear as Jell-0 for Scientists to Explore.”" +"At the cellular level, cells seen individually are transparent, with all +their microscopic components fully exposed. However, once billions of +cells come together to form organs like the brain, the addition of lipids +(fats, oils, waxes, and chemicals not soluble in water) helps make the +organ opaque. The key to the new technique is to remove the lipids +while keeping the neurons intact. The scientists at Stanford did this by +placing the brain in hydrogel (a gel-like substance mainly made of +water), which binds to all the brain’s molecules except the lipids. By +placing the brain in a soapy solution with an electric field, the solution +can be flushed out of the brain, carrying along the lipids, leaving the +brain transparent. The addition of dyes can then make the neural +pathways visible. This will help to identify and map the many neural +pathways of the brain." +"Making tissue transparent is not new, but getting precisely the right +conditions necessary to make the entire brain transparent took a lot of +ingenuity. “I burned and melted more than a hundred brains,” confessed +Dr. Kwanghun Chung, one of the lead scientists in the study. The new +technique, called Clarity, can also be applied to other organs (and even +organs preserved years ago in chemicals like formalin). He has already +created transparent livers, lungs, and hearts. This new technique has +startling applications across all of medicine. In particular, it will +accelerate locating the neural pathways of the brain, which is the focus +of intense research and funding. + +FOUR FUNDAMENTAL FORCES" +"FOUR FUNDAMENTAL FORCES + + The success of this first generation of brain scans has been nothing less +than spectacular. Before their introduction, only about thirty or so +regions of the brain were known with any certainty. Now the MRI +machine alone can identify two to three hundred regions of the brain, +opening up entirely new frontiers for brain science. With so many new +scanning technologies being introduced from physics just within the last + +fifteen years, one might wonder: Are there more? The answer is yes, but +they will be variations and refinements of the previous ones, not +radically new technologies. This is because there are only four +fundamental forces—gravitational, electromagnetic, weak nuclear, and +strong nuclear—that rule the universe. (Physicists have tried to find +evidence for a fifth force, but so far all such attempts have failed.)" +"The electromagnetic force, which lights up our cities and represents +the energy of electricity and magnetism, is the source of almost all the +new scanning technologies (with the exception of the PET scan, which is +governed by the weak nuclear force). Because physicists have had over +150 years of experience working with the electromagnetic force, there is +no mystery in creating new electric and magnetic fields, so any new +brain-scanning technology will most likely be a novel modification of +existing technologies, rather than being something entirely new. As with +most technology, the size and cost of these machines will drop, vastly +increasing the widespread use of these sophisticated instruments. +Already physicists are doing the basic calculations necessary to make an +MRI machine fit into a cell phone. At the same time, the fundamental +challenge facing these brain scans is resolution, both spatial and +temporal. The spatial resolution of MRI scans will increase as the" +"temporal. The spatial resolution of MRI scans will increase as the +magnetic field becomes more uniform and as the electronics become +more sensitive. At present, MRI scans can see only dots or voxels within +a fraction of a millimeter. But each dot may contain hundreds of +thousands of neurons. New scanning technology should reduce this even +further. The holy grail of this approach would be to create an MRI-like +machine that could identify individual neurons and their connections." +"The temporal resolution of MRI machines is also limited because they +analyze the flow of oxygenated blood in the brain. The machine itself +has very good temporal resolution, but tracing the flow of blood slows it +down. In the future, other MRI machines will be able to locate different +substances that are more directly connected to the firing of neurons, +thereby allowing real-time analysis of mental processes. No matter how +spectacular the successes of the past fifteen years, then, they were just a +taste of the future. + +NEW MODELS OF THE BRAIN + + Historically, with each new scientific discovery, a new model of the +brain has emerged. One of the earliest models of the brain was the +“homunculus,” a little man who lived inside the brain and made all the +decisions. This picture was not very helpful, since it did not explain what +was happening in the brain of the homunculus. Perhaps there was a +homunculus hiding inside the homunculus." +"With the arrival of simple mechanical devices, another model of the +brain was proposed: that of a machine, such as a clock, with mechanical +wheels and gears. This analogy was useful for scientists and inventors +like Leonardo da Vinci, who actually designed a mechanical man." +"During the late 1800s, when steam power was carving out new +empires, another analogy emerged, that of a steam engine, with flows of +energy competing with one another. This hydraulic model, historians +have conjectured, affected Sigmund Freud’s picture of the brain, in +which there was a continual struggle between three forces: the ego +(representing the self and rational thought), the id (representing +repressed desires), and the superego (representing our conscience). In +this model, if too much pressure built up because of a conflict among +these three, there could be a regression or general breakdown of the +entire system. This model was ingenious, but as even Freud himself +admitted, it required detailed studies of the brain at the neuronal level, +which would take another century." +"Early in the last century, with the rise of the telephone, another +analogy surfaced—that of a giant switchboard. The brain was a mesh of +telephone lines connected into a vast network. Consciousness was a long +row of telephone operators sitting in front of a large panel of switches, +constantly plugging and unplugging wires. Unfortunately, this model +said nothing about how these messages were wired together to form the +brain. + +With the rise of the transistor, yet another model became fashionable: +the computer. The old-fashioned switching stations were replaced by +microchips containing hundreds of millions of transistors. Perhaps the +“mind” was just a software program running on “wetware” (i.e., brain +tissue rather than transistors). This model is an enduring one, even +today, but it has limitations. The transistor model cannot explain how +the brain performs computations that would require a computer the size +of New York City. Plus the brain has no programming, no Windows" +"operating system or Pentium chip. (Also, a PC with a Pentium chip is +extremely fast, but it has a bottleneck. All calculations must pass + + through this single processor. The brain is the opposite. The firing of +each neuron is relatively slow, but it more than makes up for this by +having 100 billion neurons processing data simultaneously. Therefore a +slow parallel processor can trump a very fast single processor.) + +The most recent analogy is that of the Internet, which lashes together +billions of computers. Consciousness, in this picture, is an “emergent” +phenomenon, miraculously arising out of the collective action of billions +of neurons. (The problem with this picture is that it says absolutely +nothing about how this miracle occurs. It brushes all the complexity of +the brain under the rug of chaos theory.)" +"No doubt each of these analogies has kernels of truth, but none of +them truly captures the complexity of the brain. However, one analogy +for the brain that I have found useful (albeit still imperfect) is that of a +large corporation. In this analogy, there is a huge bureaucracy and lines +of authority, with vast flows of information channeled between different +offices. But the important information eventually winds up at the +command center with the CEO. There the final decisions are made. + +If this analogy of the brain to a large corporation is valid, then it +should be able to explain certain peculiar features of the brain:" +"• Most information is “subconscious” —that is, the CEO is blissfully +unaware of the vast, complex information that is constantly flowing +inside the bureaucracy. In fact, only a tiny amount of information +finally reaches the desk of the CEO, who can be compared to the +prefrontal cortex. The CEO just has to know information important +enough to get his attention; otherwise, he would be paralyzed by an +avalanche of extraneous information. + +This arrangement is probably a by-product of evolution, since our +ancestors would have been overwhelmed with superfluous, +subconscious information flooding their brains when facing an +emergency. We are all mercifully unaware of the trillions of +calculations being processed in our brains. Upon encountering a +tiger in the forest, one does not have to be bothered with the status +of our stomach, toes, hair, etc. All one has to know is how to run. + +• “Emotions” are rapid decisions made independently at a lower" +"• “Emotions” are rapid decisions made independently at a lower + +level. Since rational thought takes many seconds, this means that it +is often impossible to make a reasoned response to an emergency; +hence lower-level brain regions must rapidly assess the situation and +make a decision, an emotion, without permission from the top. + +So emotions (fear, anger, horror, etc.) are instantaneous red flags + + made at a lower level, generated by evolution, to warn the +command center of possibly dangerous or serious situations. We +have little conscious control over emotions. For example, no matter +how much we practice giving a speech to a large audience, we still +feel nervous. + +Rita Carter, author of Mapping the Mind, writes, “Emotions are not +feelings at all but a set of body-rooted survival mechanisms that +have evolved to turn us away from danger and propel us forward to +things that may be of benefit.” + +• There is a constant clamoring for the attention of the CEO." +"• There is a constant clamoring for the attention of the CEO. + +There is no single homunculus, CPU, or Pentium chip making +decisions; instead, the various subcenters within the command +center are in constant competition with one another, vying for the +attention of the CEO. So there is no smooth, steady continuity of +thought, but the cacophony of different feedback loops competing +with one another. The concept of “I,” as a single, unified whole +making all decisions continuously, is an illusion created by our own +subconscious minds. + +Mentally we feel that our mind is a single entity, continuously and +smoothly processing information, totally in charge of our decisions. +But the picture emerging from brain scans is quite different from the +perception we have of our own mind. + +MIT professor Marvin Minsky, one of the founding fathers of +artificial intelligence, told me that the mind is more like a “society +of minds,” with different submodules, each trying to compete with +the others." +"When I interviewed Steven Pinker, a psychologist at Harvard +University, I asked him how consciousness emerges out of this mess. +He said that consciousness was like a storm raging in our brain. He +elaborated on this when he wrote that “the intuitive feeling we have +that there’s an executive T that sits in a control room of our brain, + +scanning the screens of the senses and pushing the buttons of our +muscles, is an illusion. Consciousness turns out to consist of a +maelstrom of events distributed across the brain. These events +compete for attention, and as one process outshouts the others, the +brain rationalizes the outcome after the fact and concocts the +impression that a single self was in charge all along.” + +• Final decisions are made by the CEO in the command center." +"• Final decisions are made by the CEO in the command center. + + Almost all the bureaucracy is devoted to accumulating and +assembling information for the CEO, who meets only with the +directors of each division. The CEO tries to mediate all the +conflicting information pouring into the command center. The buck +stops here. The CEO, located in the prefrontal cortex, has to make +the final decision. While most decisions are made by instinct in +animals, humans make higher-level decisions after sifting through +different bodies of information from our senses. + +• Information flows are hierarchical. Because of the vast amount of +information that must flow upward toward the CEO’s office, or +downward to the support staff, information must be arranged in +complex arrays of nested networks, with many branches. Think of a +pine tree, with the command center on top and a pyramid of +branches flowing downward, branching out into many subcenters." +"There are, of course, differences between a bureaucracy and the +structure of thought. The first rule of any bureaucracy is that “it +expands to fill the space allotted to it.” But wasting energy is a +luxury the brain cannot afford. The brain consumes only about +twenty watts of power (the power of a dim lightbulb), but that is +probably the maximum energy it can consume before the body +becomes dysfunctional. If it generates more heat, it will cause tissue +damage. Therefore the brain is constantly using shortcuts to +conserve energy. We will see throughout this book the clever and +ingenious devices that evolution has crafted, without our +knowledge, to cut corners. + +IS “REALITY” REALLY REAL? + +Everyone knows the expression “seeing is believing.” Yet much of what" +"IS “REALITY” REALLY REAL? + +Everyone knows the expression “seeing is believing.” Yet much of what + +we see is actually an illusion. For example, when we see a typical +landscape, it seems like a smooth, movielike panorama. In reality, there +is a gaping hole in our field of vision, corresponding to the location of +the optic nerve in the retina. We should see this large ugly black spot +wherever we look. But our brains fill in that hole by papering it over, by +averaging it out. This means that part of our vision is actually fake, +generated by our subconscious minds to deceive us. + +Also, we see only the center of our field of vision, called the fovea, +with clarity. The peripheral part is blurry, in order to save energy. But +the fovea is very small. To capture as much information as possible with +the tiny fovea, the eye darts around constantly. This rapid, jiggling +motion of our eyes is called saccades. All this is done subconsciously," +"giving us the false impression that our field of vision is clear and +focused. + +When I was a child and first saw a diagram showing the +electromagnetic spectrum in its true glory, I was shocked. I had been +totally unaware that huge parts of the EM spectrum (e.g., infrared light, +UV light, X-rays, gamma rays) were totally invisible to us. I began to +realize that what I saw with my eyes was only a tiny, crude +approximation of reality. (There is an old saying: “If appearance and +essence were the same thing, there would be no need for science.”) We +have sensors in the retina that can detect only red, green, and blue. This +means that we’ve never actually seen yellow, brown, orange, and a host +of other colors. These colors do exist, but our brain can approximate +each of them only by mixing different amounts of red, green, and blue. +(You can see this if you look at an old color-TV screen very carefully. +You see only a collection of red, green, and blue dots. Color TV is +actually an illusion.)" +"Our eyes also fool us into thinking we can see depth. The retinas of +our eyes are two-dimensional, but because we have two eyes separated +by a few inches, the left and right brain merge these two images, giving +us the false sense of a third dimension. For more distant objects, we can +judge how far an object is by observing how they move when we move +our head. This is called parallax. + +(This parallax explains the fact that children sometimes complain that +“the moon is following me.” Because the brain has difficulty +comprehending the parallax of an object as distant as the moon, it + +appears as if the moon is always a fixed distance “behind” them, but it’s +just an illusion caused by the brain taking a shortcut.) + +THE SPLIT-BRAIN PARADOX" +"THE SPLIT-BRAIN PARADOX + +One way in which this picture, based on the corporate hierarchy of a +company, deviates from the actual structure of the brain can be seen in +the curious case of split-brain patients. One unusual feature of the brain +is that it has two nearly identical halves, or hemispheres, the left and +right. Scientists have long wondered why the brain has this unnecessary +redundancy, since the brain can operate even if one entire hemisphere is +completely removed. No normal corporate hierarchy has this strange +feature. Furthermore, if each hemisphere has consciousness, does this +mean that we have two separate centers of consciousness inside one +skull?" +"Dr. Roger W. Sperry of the California Institute of Technology won the +Nobel Prize in 1981 for showing that the two hemispheres of the brain +are not exact carbon copies of each other, but actually perform different +duties. This result created a sensation in neurology (and also spawned a +cottage industry of dubious self-help books that claim to apply the left- +brain, right-brain dichotomy to your life). + +Dr. Sperry was treating epileptics, who sometimes suffer from grand +mal seizures often caused by feedback loops between the two +hemispheres that go out of control. Like a microphone screeching in our +ears because of a feedback loop, these seizures can become life- +threatening. Dr. Sperry began by severing the corpus callosum, which +connects the two hemispheres of the brain, so that they no longer +communicated and shared information between the left and right side of +the body. This usually stopped the feedback loop and the seizures." +"At first, these split-brain patients seemed perfectly normal. They were +alert and could carry on a natural conversation as if nothing had +happened. But a careful analysis of these individuals showed that +something was very different about them. + +Normally the hemispheres complement each other as thoughts move +back and forth between the two. The left brain is more analytical and +logical. It is where verbal skills are found, while the right brain is more + +holistic and artistic. But the left brain is the dominant one and makes the +final decisions. Commands pass from the left brain to the right brain via +the corpus callosum. But if that connection is cut, it means that the right +brain is now free from the dictatorship of the left brain. Perhaps the +right brain can have a will of its own, contradicting the wishes of the +dominant left brain." +"In short, there could be two wills acting within one skull, sometimes +struggling for control of the body. This creates the bizarre situation +where the left hand (controlled by the right brain) starts to behave +independently of your wishes, as if it were an alien appendage. + +There is one documented case in which a man was about to hug his +wife with one hand, only to find that the other hand had an entirely +different agenda. It delivered a right hook to her face. Another woman +reported that she would pick out a dress with one hand, only to see her +other hand grab an entirely different outfit. Meanwhile, one man had +difficulty sleeping at night thinking that his other rebellious hand might +strangle him. + +At times, split-brain people think they are living in a cartoon, where +one hand struggles to control the other. Physicians sometimes call this + + the Dr. Strangelove syndrome, because of a scene in the movie in which +one hand has to fight against the other hand." +"Dr. Sperry, after detailed studies of split-brain patients, finally +concluded that there could be two distinct minds operating in a single +brain. He wrote that each hemisphere is “indeed a conscious system in +its own right, perceiving, thinking, remembering, reasoning, willing, and +emoting, all at a characteristically human level, and ... both the left and +right hemisphere may be conscious simultaneously in different, even in +mutually conflicting, mental experiences that run along in parallel.”" +"When I interviewed Dr. Michael Gazzaniga of the University of +California, Santa Barbara, an authority on split-brain patients, I asked +him how experiments can be done to test this theory. There are a variety +of ways to communicate separately to each hemisphere without the +knowledge of the other hemisphere. One can, for example, have the +subject wear special glasses on which questions can be shown to each +eye separately, so that directing questions to each hemisphere is easy. +The hard part is trying to get an answer from each hemisphere. Since the +right brain cannot speak (the speech centers are located only in the left + +brain), it is difficult to get answers from the right brain. Dr. Gazzaniga +told me that to find out what the right brain was thinking, he created an +experiment in which the (mute) right brain could “talk” by using +Scrabble letters." +"He began by asking the patient’s left brain what he would do after +graduation. The patient replied that he wanted to become a draftsman. +But things got interesting when the (mute) right brain was asked the +same question. The right brain spelled out the words: “automobile +racer.” Unknown to the dominant left brain, the right brain secretly had +a completely different agenda for the future. The right brain literally had +a mind of its own. + +Rita Carter writes, “The possible implications of this are mind- +boggling. It suggests that we might all be carrying around in our skulls a +mute prisoner with a personality, ambition, and self-awareness quite +different from the day-to-day entity we believe ourselves to be.”" +"Perhaps there is truth to the oft-heard statement that “inside him, +there is someone yearning to be free.” This means that the two +hemispheres may even have different beliefs. For example, the +neurologist V. S. Ramanchandran describes one split-brain patient who, +when asked if he was a believer or not, said he was an atheist, but his +right brain declared he was a believer. Apparently, it is possible to have +two opposing religious beliefs residing in the same brain. Ramachandran +continues: “If that person dies, what happens? Does one hemisphere go + + to heaven and the other go to hell? I don’t know the answer to that.” + +(It is conceivable, therefore, that a person with a split-brain +personality might be both Republican and Democrat at the same time. If +you ask him whom he will vote for, he will give you the candidate of the +left brain, since the right brain cannot speak. But you can imagine the +chaos in the voting booth when he has to pull the lever with one hand.) + +WHO IS IN CHARGE?" +"WHO IS IN CHARGE? + +One person who has spent considerable time and done much research to +understand the problem of the subconscious mind is Dr. David +Eagleman, a neuroscientist at the Baylor College of Medicine. When I +interviewed him, I asked him, If most of our mental processes are + +subconscious, then why are we ignorant of this important fact? He gave +an example of a young king who inherits the throne and takes credit for +everything in the kingdom, but hasn’t the slightest clue about the +thousands of staff, soldiers, and peasants necessary to maintain the +throne." +"Our choice of politicians, marriage partners, friends, and future +occupations are all influenced by things that we are not conscious of. +(For example, it is an odd result, he says, that “people named Denise or +Dennis are disproportionately likely to become dentists, while people +named Laura or Lawrence are more likely to become lawyers, and +people with names like George or Georgina to become geologists.”) This +also means that what we consider to be “reality” is only an +approximation that the brain makes to fill in the gaps. Each of us sees +reality in a slightly different way. For example, he pointed out, “at least +15 percent of human females possess a genetic mutation that gives them +an extra (fourth) type of color photoreceptor—and this allows them to +discriminate between colors that look identical to the majority of us with +a mere three types of color photoreceptors.”" +"Clearly, the more we understand the mechanics of thought, the more +questions arise. Precisely what happens in the command center of the +mind when confronted with a rebellious shadow command center? What +do we mean by “consciousness” anyway, if it can be split in half? And +what is the relationship between consciousness and “self” and “self- +awareness”? + +If we can answer these difficult questions, then perhaps it will pave +the way for understanding nonhuman consciousness, the consciousness +of robots and aliens from outer space, for example, which may be + + entirely different from ours. + +So let us now propose a clear answer to this deceptively complex +question: What is consciousness? + +The mind of man is capable of anything ... because everything +is in it, all the past as well as all the future. + +—JOSEPH CONRAD + +Consciousness can reduce even the most fastidious thinker to +blabbering incoherence. + +—COLIN MCGINN + +2 CONSCIOUSNESS—A PHYSICIST’S VIEWPOINT" +"—COLIN MCGINN + +2 CONSCIOUSNESS—A PHYSICIST’S VIEWPOINT + +The idea of consciousness has intrigued philosophers for centuries, but +it has resisted a simple definition, even to this day. The philosopher +David Chalmers has cataloged more than twenty thousand papers +written on the subject; nowhere in science have so many devoted so +much to create so little consensus. The seventeenth-century thinker +Gottfried Leibniz once wrote, “If you could blow the brain up to the size +of a mill and walk about inside, you would not find consciousness.” + +Some philosophers doubt that a theory of consciousness is even +possible. They claim that consciousness can never be explained since an +object can never understand itself, so we don’t even have the mental +firepower to solve this perplexing question. Harvard psychologist Steven +Pinker writes, “We cannot see ultraviolet light. We cannot mentally +rotate an object in the fourth dimension. And perhaps we cannot solve +conundrums like free will and sentience.”" +"In fact, for most of the twentieth century, one of the dominant theories +of psychology, behaviorism, denied the importance of consciousness +entirely. Behaviorism is based on the idea that only the objective +behavior of animals and people is worthy of study, not the subjective, +internal states of the mind. + +Others have given up trying to define consciousness, and try simply to +describe it. Psychiatrist Giulio Tononi has said, “Everybody knows what +consciousness is: it is what abandons you every night when you fall into +dreamless sleep and returns the next morning when you wake up.” + + Although the nature of consciousness has been debated for centuries, +there has been little resolution. Given that physicists created many of the +inventions that have made the explosive advancements in brain science +possible, perhaps it will be useful to follow an example from physics in +reexamining this ancient question. + +HOW PHYSICISTS UNDERSTAND THE UNIVERSE" +"HOW PHYSICISTS UNDERSTAND THE UNIVERSE + +When a physicist tries to understand something, first he collects data and +then he proposes a “model,” a simplified version of the object he is +studying that captures its essential features. In physics, the model is +described by a series of parameters (e.g., temperature, energy, time). +Then the physicist uses the model to predict its future evolution by +simulating its motions. In fact, some of the world’s largest +supercomputers are used to simulate the evolution of models, which can +describe protons, nuclear explosions, weather patterns, the big bang, and +the center of black holes. Then you create a better model, using more +sophisticated parameters, and simulate it in time as well." +"For example, when Isaac Newton was puzzling over the motion of the +moon, he created a simple model that would eventually change the +course of human history: he envisioned throwing an apple in the air. The +faster you threw the apple, he reasoned, the farther it would travel. If +you threw it fast enough, in fact, it would encircle the Earth entirely, +and might even return to its original point. Then, Newton claimed, this +model represented the path of the moon, so the forces that guided the +motion of the apple circling the Earth were identical to the forces +guiding the moon." +"But the model, by itself, was still useless. The key breakthrough came +when Newton was able to use his new theory to simulate the future, to +calculate the future position of moving objects. This was a difficult +problem, requiring him to create an entirely new branch of mathematics, +called calculus. Using this new mathematics, Newton was then able to +predict the trajectory of not just the moon, but also Halley’s Comet and +the planets. Since then, scientists have used Newton’s laws to simulate +the future path of moving objects, from cannonballs, machines, +automobiles, and rockets to asteroids and meteors, and even stars and +galaxies. + +The success or failure of a model depends on how faithfully it +reproduces the basic parameters of the original. In this case, the basic +parameter was the location of the apple and the moon in space and time. +By allowing this parameter to evolve (i.e., letting time move forward), +Newton unlocked, for the first time in history, the action of moving" +"bodies, which is one of the most important discoveries in science. + +Models are useful, until they are replaced by even more accurate +models described by better parameters. Einstein replaced Newton’s + +picture of forces acting on apples and moons with a new model based on +a new parameter, the curvature of space and time. An apple moved not +because the Earth exerted a force on it, but because the fabric of space +and time was stretched by the Earth, so the apple was simply moving +along the surface of a curved space-time. From this, Einstein could then +simulate the future of the entire universe. Now, with computers, we can +run simulations of this model into the future and create gorgeous +pictures presenting the collisions of black holes. + +Let us now incorporate this basic strategy into a new theory of +consciousness. + +DEFINITION OF CONSCIOUSNESS" +"DEFINITION OF CONSCIOUSNESS + +I’ve taken bits and pieces from previous descriptions of consciousness in +the fields of neurology and biology in order to define consciousness as +follows: + +Consciousness is the process of creating a model of the world +using multiple feedback loops in various parameters (e.g., in +temperature, space, time, and in relation to others), in order to +accomplish a goal (e.g., find mates, food, shelter). + +I call this the “space-time theory of consciousness,” because it +emphasizes the idea that animals create a model of the world mainly in +relation to space, and to one another, while humans go beyond and +create a model of the world in relation to time, both forward and +backward." +"For example, the lowest level of consciousness is Level 0, where an +organism is stationary or has limited mobility and creates a model of its +place using feedback loops in a few parameters (e.g., temperature). For +example, the simplest level of consciousness is a thermostat. It +automatically turns on an air conditioner or heater to adjust the +temperature in a room, without any help. The key is a feedback loop +that turns on a switch if the temperature gets too hot or cold. (For +example, metals expand when heated, so a thermostat can turn on a +switch if a metal strip expands beyond a certain point.) + + Each feedback loop registers “one unit of consciousness,” so a +thermostat would have a single unit of Level 0 consciousness, that is, +Level 0:1." +"In this way, we can rank consciousness numerically, on the basis of +the number and complexity of the feedback loops used to create a model +of the world. Consciousness is then no longer a vague collection of +undefined, circular concepts, but a system of hierarchies that can be +ranked numerically. For example, a bacterium or a flower has many +more feedback loops, so they would have a higher level of Level 0 +consciousness. A flower with ten feedback loops (which measure +temperature, moisture, sunlight, gravity, etc.), would have a Level 0:10 +consciousness." +"Organisms that are mobile and have a central nervous system have +Level I consciousness, which includes a new set of parameters to +measure their changing location. One example of Level I consciousness +would be reptiles. They have so many feedback loops that they +developed a central nervous system to handle them. The reptilian brain +would have perhaps one hundred or more feedback loops (governing +their sense of smell, balance, touch, sound, sight, blood pressure, etc., +and each of these contains more feedback loops). For example, eyesight +alone involves a large number of feedback loops, since the eye can +recognize color, movement, shapes, light intensity, and shadows. +Similarly, the reptile’s other senses, such as hearing and taste, require +additional feedback loops. The totality of these numerous feedback loops +creates a mental picture of where the reptile is located in the world, and +where other animals (e.g., prey) are located as well. Level I" +"where other animals (e.g., prey) are located as well. Level I +consciousness, in turn, is governed mainly by the reptilian brain, located +in the back and center of the human head." +"Next we have Level II consciousness, where organisms create a model +of their place not only in space but also with respect to others (i.e., they +are social animals with emotions). The number of feedback loops for +Level II consciousness explodes exponentially, so it is useful to introduce +a new numerical ranking for this type of consciousness. Forming allies, +detecting enemies, serving the alpha male, etc., are all very complex +behaviors requiring a vastly expanded brain, so Level II consciousness +coincides with the formation of new structures of the brain in the form +of the limbic system. As noted earlier, the limbic system includes the + +hippocampus (for memories), amygdala (for emotions), and the +thalamus (for sensory information), all of which provide new parameters +for creating models in relation to others. The number and type of +feedback loops therefore change." +"We define the degree of Level II consciousness as the total number of +distinct feedback loops required for an animal to interact socially with +members of its grouping. Unfortunately, studies of animal consciousness +are extremely limited, so little work has been done to catalog all the +ways in which animals communicate socially with one another. But to a +crude first approximation, we can estimate Level II consciousness by +counting the number of fellow animals in its pack or tribe and then +listing the total number of ways in which the animal interacts +emotionally with each one. This would include recognizing rivals and +friends, forming bonds with others, reciprocating favors, building +coalitions, understanding your status and the social ranking of others, +respecting the status of your superiors, displaying your power over your +inferiors, plotting to rise on the social ladder, etc. (We exclude insects +from Level II, because although they have social relations with members" +"from Level II, because although they have social relations with members +of their hive or group, they have no emotions as far as we can tell.)" +"Despite the lack of empirical studies of animal behaviors, we can give +a very rough numerical rank to Level II consciousness by listing the total +number of distinct emotions and social behaviors that the animal can +exhibit. For example, if a wolf pack consists of ten wolves, and each wolf +interacts with all the others with fifteen different emotions and gestures, +then its level of consciousness, to a first approximation, is given by the +product of the two, or 150, so it would have Level 11:150 consciousness. +This number takes into account both the number of other animals it has +to interact with as well as the number of ways it can communicate with +each one. This number only approximates the total number of social +interactions that the animal can display, and will undoubtedly change as +we learn more about its behavior." +"(Of course, because evolution is never clean and precise, there are +caveats that we have to explain, such as the level of consciousness of +social animals that are solitary hunters. We will do so in the notes.) + +LEVEL III CONSCIOUSNESS: SIMULATING THE FUTURE + +With this framework for consciousness, we see that humans are not +unique, and that there is a continuum of consciousness. As Charles +Darwin once commented, “The difference between man and the higher +animals, great as it is, is certainly one of degree and not of kind.” But +what separates human consciousness from the consciousness of animals? +Humans are alone in the animal kingdom in understanding the concept +of tomorrow. Unlike animals, we constantly ask ourselves “What if?” +weeks, months, and even years into the future, so I believe that Level III +consciousness creates a model of its place in the world and then +simulates it into the future, by making rough predictions. We can +summarize this as follows:" +"Human consciousness is a specific form of consciousness that +creates a model of the world and then simulates it in time, by +evaluating the past to simulate the future. This requires +mediating and evaluating many feedback loops in order to +make a decision to achieve a goal. + +By the time we reach Level III consciousness, there are so many +feedback loops that we need a CEO to sift through them in order to +simulate the future and make a final decision. Accordingly, our brains +differ from those of other animals, especially in the expanded prefrontal +cortex, located just behind the forehead, which allows us to “see” into +the future." +"Dr. Daniel Gilbert, a Harvard psychologist, has written, “The greatest +achievement of the human brain is its ability to imagine objects and +episodes that do not exist in the realm of the real, and it is this ability +that allows us to think about the future. As one philosopher noted, the +human brain is an ‘anticipation machine,’ and ‘making the future’ is the +most important thing it does.” + +Using brain scans, we can even propose a candidate for the precise +area of the brain where simulation of the future takes place. Neurologist +Michael Gazzaniga notes that “area 10 (the internal granular layer IV), +in the lateral prefrontal cortex, is almost twice as large in humans as in +apes. Area 10 is involved with memory and planning, cognitive +flexibility, abstract thinking, initiating appropriate behavior, and +inhibiting inappropriate behavior, learning rules, and picking out" +"relevant information from what is perceived through the senses.” (For +this book, we will refer to this area, in which decision making is +concentrated, as the dorsolateral prefrontal cortex, although there is +some overlap with other areas of the brain.) + +Although animals may have a well-defined understanding of their +place in space and some have a degree of awareness of others, it is not +clear if they systematically plan for the future and have an +understanding of “tomorrow.” Most animals, even social animals with +well-developed limbic systems, react to situations (e.g., the presence of +predators or potential mates) by relying mainly on instinct, rather than +systematically planning into the future." +"For instance, mammals do not plan for the winter by preparing to +hibernate, but largely follow instinct as the temperature drops. There is +a feedback loop that regulates their hibernation. Their consciousness is +dominated by messages coming in from their senses. There is no +evidence that they systemically sift through various plans and schemes + + as they prepare to hibernate. Predators, when they use cunning and +disguise to stalk an unsuspecting prey, do anticipate future events, but +this planning is limited only to instinct and the duration of the hunt. +Primates are adept at devising short-term plans (e.g., finding food), but +there is no indication that they plan more than a few hours ahead." +"Humans are different. Although we do rely on instinct and emotions in +many situations, we also constantly analyze and evaluate information +from many feedback loops. We do this by running simulations sometimes +even beyond our own life span and even thousands of years into the +future. The point of running simulations is to evaluate various +possibilities to make the best decision to fulfill a goal. This occurs in the +prefrontal cortex, which allows us to simulate the future and evaluate +the possibilities in order to chart the best course of action. + +This ability evolved for several reasons. First, having the ability to +peer into the future has enormous evolutionary benefits, such as evading +predators and finding food and mates. Second, it allows us to choose +among several different outcomes and to select the best one." +"Third, the number of feedback loops explodes exponentially as we go +from Level 0 to Level I to Level II, so we need a “CEO” to evaluate all +these conflicting, competing messages. Instinct is no longer enough. +There has to be a central body that evaluates each of these feedback + +loops. This distinguishes human consciousness from that of the animals. +These feedback loops are evaluated, in turn, by simulating them into the +future to obtain the best outcome. If we didn’t have a CEO, chaos would +ensue and we would have sensory overload. + +A simple experiment can demonstrate this. David Eagleman describes +how you can take a male stickleback fish and have a female fish trespass +on its territory. The male gets confused, because it wants to mate with +the female, but it also wants to defend its territory. As a result, the male +stickleback fish will simultaneously attack the female while initiating +courtship behavior. The male is driven into a frenzy, trying to woo and +kill the female at the same time." +"This works for mice as well. Put an electrode in front of a piece of +cheese. If the mouse gets too close, the electrode will shock it. One +feedback loop tells the mouse to eat the cheese, but another one tells the +mouse to stay away and avoid being shocked. By adjusting the location +of the electrode, you can get the mouse to oscillate, torn between two +conflicting feedback loops. While a human has a CEO in its brain to +evaluate the pros and cons of the situation, the mouse, governed by two +conflicting feedback loops, goes back and forth. (This is like the proverb +about the donkey that starves to death because it is placed between two + + equal bales of hay.)" +"equal bales of hay.) + +Precisely how does the brain simulate the future? The human brain is +flooded by a large amount of sensory and emotional data. But the key is +to simulate the future by making causal links between events—that is, if +A happens, then B happens. But if B happens, then C and D might result. +This sets off a chain reaction of events, eventually creating a tree of +possible cascading futures with many branches. The CEO in the +prefrontal cortex evaluates the results of these causal trees in order to +make the ultimate decision. + +Let’s say you want to rob a bank. How many realistic simulations of +this event can you make? To do this, you have to think of the various +causal links involving the police, bystanders, alarm systems, relations +with fellow criminals, traffic conditions, the DA’s office, etc. For a +successful simulation of the robbery, hundreds of causal links may have +to be evaluated." +"It is also possible to measure this level of consciousness numerically. +Let’s say that a person is given a series of different situations like the one + +above and is asked to simulate the future of each. The sum total number +of causal links that the person can make for all these situations can be +tabulated. (One complication is that there are an unlimited number of +causal links that a person might make for a variety of conceivable +situations. To get around this complication, we divide this number by +the average number of causal links obtained from a large control group. +Like the IQ exam, one may multiply this number by 100. So a person’s +level of consciousness, for example, might be Level 111:100, meaning that +the person can simulate future events just like the average person.) + +We summarize these levels of consciousness in the following diagram: + +LEVELS OF CONSCIOUSNESS FOR DIFFERENT SPECIES + +LEVEL + +SPECIES + +PARAMETER + +BRAIN STRUCTURE + +0 + +| Plants + + | Temperature, sunshine + +None + +1" +"SPECIES + +PARAMETER + +BRAIN STRUCTURE + +0 + +| Plants + + | Temperature, sunshine + +None + +1 + +Reptiles + +j Space + +Brain stem + +II + +| Mammals + +| Social relations + +j Limbic system + +III + +j Humans + +| Time (esp. future) + +j Prefrontal cortex + +Space-time theory of consciousness. We define consciousness as the process of creating a model of the +world using +multiple feedback loops in various parameters (e.g., in space, time, and in relation to others), in order to +accomplish a +goal. Human consciousness is a particular type that involves mediating between these feedback loops +by simulating the + +future and evaluating the past." +"future and evaluating the past. + +(Notice that these categories correspond to the rough evolutionary +levels we find in nature—e.g., reptiles, mammals, and humans. However, +there are also gray areas, such as animals that might possess tiny aspects +of different levels of consciousness, animals that do some rudimentary +planning, or even single cells that communicate with one another. This +chart is meant only to give you the larger, global picture of how +consciousness is organized across the animal kingdom.) + +WHAT IS HUMOR? WHY DO WE HAVE EMOTIONS? + + All theories have to be falsifiable. The challenge for the space-time +theory of consciousness is to explain all aspects of human consciousness" +"in this framework. It can be falsified if there are patterns of thought that +cannot be brought into this theory. A critic might say that surely our +sense of humor is so quixotic and ephemeral that it is beyond +explanation. We spend a great deal of time laughing with our friends or +at comedians, yet it seems that humor has nothing to do with our +simulations of the future. But consider this. Much of humor, such as +telling a joke, depends on the punch line." +"When hearing a joke, we can’t help but simulate the future and +complete the story ourselves (even if we’re unaware that we’re doing +so). We know enough about the physical and social world that we can +anticipate the ending, so we burst out with laughter when the punch line +gives us a totally unexpected conclusion. The essence of humor is when +our simulation of the future is suddenly disrupted in surprising ways. +(This was historically important for our evolution since success depends, +in part, on our ability to simulate future events. Since life in the jungle is +full of unanticipated events, anyone who can foresee unexpected +outcomes has a better chance at survival. In this way, having a well- +developed sense of humor is actually one indication of our Level III +consciousness and intelligence; that is, the ability to simulate the future.)" +"For example, W. C. Fields was once asked a question about social +activities for youth. He was asked, “Do you believe in clubs for young +people?” He replied, “Only when kindness fails.” + +The joke has a punch line only because we mentally simulate a future +in which children have social clubs, while W. C. Fields simulates a +different future involving clubs as a weapon. (Of course, if a joke is +deconstructed, it loses its power, since we have already simulated +various possible futures in our minds.) + +This also explains what every comedian knows: timing is the key to +humor. If the punch line is delivered too quickly, then the brain hasn’t +had time to simulate the future, so there is no experience of the +unanticipated. If the punch line is delivered too late, the brain has +already had time to simulate various possible futures, so again the punch +line loses the element of surprise." +"(Humor has other functions, of course, such as bonding with fellow +members of our tribe. In fact, we use our sense of humor as a way to size +up the character of others. This, in turn, is essential to determine our +status within society. So in addition, laughter helps define our position + + in the social world, i.e., Level II consciousness.) + +WHY DO WE GOSSIP AND PLAY? + +Even seemingly trivial activities, such as engaging in idle gossip or +horsing around with our friends, must be explained in this framework. +(If a Martian were to visit a supermarket checkout line and view the +huge display of gossip magazines, it might conclude that gossip is the +main activity of humans. This observation would not be far off.)" +"Gossiping is essential for survival because the complex mechanics of +social interactions are constantly changing, so we have to make sense of +this ever-shifting social terrain. This is Level II consciousness at work. +But once we hear a piece of gossip, we immediately run simulations to +determine how this will affect our own standing in the community, +which moves us to Level III consciousness. Thousands of years ago, in +fact, gossip was the only way to obtain vital information about the tribe. +One’s very life often depended on knowing the latest gossip." +"Something as superfluous as “play” is also an essential feature of +consciousness. If you ask children why they like to play, they will say, +“Because it’s fun.” But that invites the next question: What is fun? +Actually, when children play, they are often trying to reenact complex +human interactions in simplified form. Human society is extremely +sophisticated, much too involved for the developing brains of young +children, so children run simplified simulations of adult society, playing +games such as doctor, cops and robber, and school. Each game is a +model that allows children to experiment with a small segment of adult +behavior and then run simulations into the future. (Similarly, when +adults engage in play, such as a game of poker, the brain constantly +creates a model of what cards the various players possess, and then +projects that model into the future, using previous data about people’s +personality, ability to bluff, etc. The key to games like chess, cards, and" +"personality, ability to bluff, etc. The key to games like chess, cards, and +gambling is the ability to simulate the future. Animals, which live +largely in the present, are not as good at games as humans are, +especially if they involve planning. Infant mammals do engage in a form +of play, but this is more for exercise, testing one another, practicing +future battles, and establishing the coming social pecking order rather" +"than simulating the future.) + +My space-time theory of consciousness might also shed light on + + another controversial topic: intelligence. Although IQ exams claim to +measure “intelligence,” IQ exams actually give no definition of +intelligence in the first place. In fact, a cynic may claim, with some +justification, that IQ is a measure of “how well you do on IQ exams,” +which is circular. In addition, IQ exams have been criticized for being +too culturally biased. In this new framework, however, intelligence may +be viewed as the complexity of our simulations of the future. Hence, a +master criminal, who may be a dropout and functionally illiterate and +score dismally low on an IQ exam, may also far outstrip the ability of the +police. Outwitting the cops may entail simply being able to run more +sophisticated simulations of the future. + +LEVEL I: STREAM OF CONSCIOUSNESS" +"LEVEL I: STREAM OF CONSCIOUSNESS + +Humans are probably alone on this planet in being able to operate on all +levels of consciousness. Using MRI scans, we can break down the +different structures involved in each level of consciousness." +"For us, Level I stream of consciousness is largely the interplay between +the prefrontal cortex and the thalamus. When taking a leisurely stroll in +the park, we are aware of the smells of the plants, the sensation of a +gentle breeze, the visual stimuli from the sun, and so on. Our senses send +signals to the spinal cord, the brain stem, and then to the thalamus, +which operates like a relay station, sorting out the stimuli and sending +them on to the various cortices of the brain. The images of the park, for +example, are sent to the occipital cortex in the back of the brain, while +the sense of touch from the wind is sent to the parietal lobe. The signals +are processed in appropriate cortices, and then sent to the prefrontal +cortex, where we finally become conscious of all these sensations. + +This is illustrated in Figure 7. + +LEVEL II: FINDING OUR PLACE IN SOCIETY" +"This is illustrated in Figure 7. + +LEVEL II: FINDING OUR PLACE IN SOCIETY + +While Level I consciousness uses sensations to create a model of our +physical location in space, Level II consciousness creates a model of our + +place in society. + +Let’s say we are going to an important cocktail party, in which people +essential to our job will be present. As we scan the room, trying to +identify people from our workplace, there is an intense interplay +between the hippocampus (which processes memories), the amygdala +(which processes emotions), and the prefrontal cortex (which puts all + + this information together). + +Figure 7. In Level I consciousness, sensory information travels through the brain stem, past the +thalamus, onto the various +cortices of the brain, and finally to the prefrontal cortex. Thus this stream of Level I consciousness is +created by the flow +of information from the thalamus to the prefrontal cortex, (illustration credit 2.1)" +"With each image, the brain automatically attaches an emotion, such as +happiness, fear, anger, or jealousy, and processes the emotion in the + +amygdala. + +If you spot your chief rival, whom you suspect of stabbing you in the +back, the emotion of fear is processed by the amygdala, which sends an +urgent message to the prefrontal cortex, alerting it to possible danger. At +the same time, signals are sent to your endocrine system to start +pumping adrenaline and other hormones into the blood, thereby +increasing your heartbeat and preparing you for a possible fight-or-flight +response. + +This is illustrated in Figure 8." +"This is illustrated in Figure 8. + +But beyond simply recognizing other people, the brain has the +uncanny ability to guess what other people are thinking about. This is +called the Theory of Mind, a theory first proposed by Dr. David Premack +of the University of Pennsylvania, which is the ability to infer the +thoughts of others. In any complex society, anyone with the ability to +correctly guess the intentions, motives, and plans of other people has a +tremendous survival advantage over those who can’t. The Theory of +Mind allows you to form alliances with others, isolate your enemies, and +solidify your friendships, which vastly increases your power and chances +of survival and mating. Some anthropologists even believe that the +mastery of the Theory of Mind was essential in the evolution of the +brain." +"Figure 8. Emotions originate and are processed in the limbic system. In Level II consciousness, we are +continually +bombarded with sensory information, but emotions are rapid-fire responses to emergencies from the +limbic system that + + do not need permission from the prefrontal cortex. The hippocampus is also important for processing +memories. So Level +II consciousness, at its core, involves the reaction of the amygdala, hippocampus, and prefrontal cortex, +(illustration + +credit 2.2) + +But how is the Theory of Mind accomplished? One clue came in 1996, +with the discovery of “mirror neurons” by Drs. Giacomo Rizzolatti, +Leonardo Fogassi, and Vittorio Gallese. These neurons fire when you are +performing a certain task and also when you see someone else +performing that same task. (Mirror neurons also fire for emotions as well +as physical acts. If you feel a certain emotion, and think another is +feeling that same emotion, then the mirror neurons will fire.)" +"Mirror neurons are essential for mimicry and also for empathy, giving + +us the ability not only to copy the complex tasks performed by others +but also to experience the emotions that person must be feeling. Mirror +neurons were thus probably essential for our evolution as human beings, +since cooperation is essential for holding the tribe together." +"Mirror neurons were first found in the premotor areas of monkey +brains. But since then, they have been found in humans in the prefrontal +cortex. Dr. V. S. Ramachandran believes that mirror neurons were +essential in giving us the power of self-awareness and concludes, “I +predict that mirror neurons will do for psychology what DNA did for +biology: they will provide a unifying framework and help explain a host +of mental abilities that have hitherto remained mysterious and +inaccessible to experiments.” (We should point out, however, that all +scientific results have to be tested and reconfirmed. There is no doubt +that certain neurons are performing this crucial behavior involved with +empathy, mimicry, etc., but there is some debate about the identity of +these mirror neurons. For example, some critics claim that perhaps these +behaviors are common to many neurons, and that there is not a single +class of neurons dedicated to this behavior.) + +LEVEL III: SIMULATING THE FUTURE" +"LEVEL III: SIMULATING THE FUTURE + +The highest level of consciousness, which is associated primarily with +Homo sapiens, is Level III consciousness, in which we take our model of +the world and then run simulations into the future. We do this by +analyzing past memories of people and events, and then simulating the + + future by making many causal links to form a “causal” tree. As we look +at the various faces at the cocktail party, we begin to ask ourselves +simple questions: How can this individual help me? How will the gossip +floating in the room play out in the future? Is anyone out to get me? + +Let’s say that you just lost your job and you are desperately looking +for a new one. In this case, as you talk to various people at the cocktail +party, your mind is feverishly simulating the future with each person +you talk to. You ask yourself, How can I impress this person? What +topics should I bring out to present my best case? Can he offer me a job?" +"Figure 9. Simulating the future, the heart of Level III consciousness, is mediated by the dorsolateral +prefrontal cortex, the +CEO of the brain, with competition between the pleasure center and the orbitofrontal cortex (which acts +to check our +impulses). This roughly resembles the outline given by Freud of the struggle between our conscience +and desires. The +actual process of simulating the future takes place when the prefrontal cortex accesses the memories of +the past in order + +to approximate future events, (illustration credit 2.3)" +"to approximate future events, (illustration credit 2.3) + +Recent brain scans have shed partial light on how the brain simulates +the future. These simulations are done mainly in the dorsolateral +prefrontal cortex, the CEO of the brain, using memories of the past. On +one hand, simulations of the future may produce outcomes that are +desirable and pleasurable, in which case the pleasure centers of the brain +light up (in the nucleus accumbens and hypothalamus). On the other +hand, these outcomes may also have a downside to them, so the +orbitofrontal cortex kicks in to warn us of possible dangers. There is a + +struggle, then, between different parts of the brain concerning the +future, which may have desirable and undesirable outcomes. Ultimately +it is the dorsolateral prefrontal cortex that mediates between these and +makes the final decisions. (See Figure 9.) (Some neurologists have +pointed out that this struggle resembles, in a crude way, the dynamics +between Freud’s ego, id, and superego.)" +"THE MYSTERY OF SELF-AWARENESS + + If the space-time theory of consciousness is correct, then it also gives us +a rigorous definition of self-awareness. Instead of vague, circular +references, we should be able to give a definition that is testable and +useful. We’ll define self-awareness as follows: + +Self-awareness is creating a model of the world and simulating + +the future in which you appear. + +Animals therefore have some self-awareness, since they have to know +where they are located if they are going to survive and mate, but it is +limited largely by instinct. + +When most animals are placed in front of a mirror, they either ignore +it or attack it, not realizing that it is an image of themselves. (This is +called the “mirror test,” which goes all the way back to Darwin.) +However, animals like elephants, the great apes, bottlenose dolphins, +orcas, and European magpies can figure out that the image they see in +the mirror represents themselves." +"Humans, however, take a giant step forward and constantly run future +simulations in which we appear as a principal actor. We constantly +imagine ourselves faced with different situations—going on a date, +applying for a job, changing careers—none of which is determined by +instinct. It is extremely difficult to stop your brain from simulating the +future, though elaborate methods have been devised (for instance, +meditation) to attempt to do so. + +Daydreaming, as an example, consists largely of our acting out +different possible futures to attain a goal. Since we pride ourselves in +knowing our limitations and strengths, it is not hard to put ourselves + +inside the model and hit the “play” button so we begin to act out +hypothetical scenarios, like being an actor in a virtual play. + +WHERE AM “I”?" +"WHERE AM “I”? + +There is probably a specific part of the brain whose job it is to unify the +signals from the two hemispheres to create a smooth, coherent sense of +self. Dr. Todd Heatherton, a psychologist at Dartmouth College, believes +that this region is located within the prefrontal cortex, in what is called +the medial prefrontal cortex. Biologist Dr. Carl Zimmer writes, “The +medial prefrontal cortex may play the same role for the self as the +hippocampus plays in memory ... [it] could be continually stitching +together a sense of who we are.” In other words, this may be the +gateway to the concept of “I,” the central region of the brain that fuses, + + integrates, and concocts a unified narrative of who we are. (This does +not mean, however, that the medial prefrontal cortext is the homunculus +sitting in our brain that controls everything.)" +"If this theory is true, then the resting brain, when we are idly +daydreaming about our friends and ourselves, should be more active +than normal, even when other parts of the brain’s sensory regions are +quiet. In fact, brain scans bear this out. Dr. Heatherton concludes, “Most +of the time we daydream—we think about something that happened to +us or what we think about other people. All this involves self-reflection.” + +The space-time theory says that consciousness is cobbled together +from many subunits of the brain, each competing with the others to +create a model of the world, and yet our consciousness feels smooth and +continuous. How can this be, when we all have the feeling that our “self” +is uninterrupted and always in charge?" +"In the previous chapter, we met the plight of split-brain patients, who +sometimes struggle with alien hands that literally have a mind of their +own. It does appear that there are two centers of consciousness living +within the same brain. So how does all this create the sense that we have +a unified, cohesive “self’ existing within our brains? + +I asked one person who may have the answer: Dr. Michael Gazzaniga, +who has spent several decades studying the strange behavior of split- +brain patients. He noticed that the left brain of split-brain patients, when" +"confronted with the fact that there seem to be two separate centers of +consciousness residing in the same skull, would simply make up strange +explanations, no matter how silly. He told me that, when presented with +an obvious paradox, the left brain will “confabulate” an answer to +explain inconvenient facts. Dr. Gazzaniga believes that this gives us the +false sense that we are unified and whole. He calls the left brain the +“interpreter,” which is constantly thinking up ideas to paper over +inconsistencies and gaps in our consciousness." +"For example, in one experiment, he flashed the word “red” to just the +left brain of a patient, and the word “banana” to just the right brain. +(Notice that the dominant left brain therefore does not know about the +banana.) Then the subject was asked to pick up a pen with his left hand +(which is governed by the right brain) and draw a picture. Naturally he +drew a picture of a banana. Remember that the right brain could do this, +because it had seen the banana, but the left brain had no clue that the +banana had been flashed to the right brain. + +Then he was asked why he had drawn the banana. Because only the +left brain controls speech, and because the left brain did not know" +"anything about a banana, the patient should have said, “I don’t know.” +Instead he said, “It is easiest to draw with this hand because this hand +can pull down easier.” Dr. Gazzaniga noted that the left brain was trying +to find some excuse for this inconvenient fact, even though the patient +was clueless about why his right hand drew the banana. + +Dr. Gazzaniga concludes, “It is the left hemisphere that engages in the +human tendency to find order in chaos, that tries to fit everything into a +story and put it into a context. It seems that it is driven to hypothesize +about the structure of the world even in the face of evidence that no +pattern exists.”" +"This is where our sense of a unified “self’ comes from. Although +consciousness is a patchwork of competing and often contradictory +tendencies, the left brain ignores inconsistencies and papers over +obvious gaps in order to give us a smooth sense of a single “I.” In other +words, the left brain is constantly making excuses, some of them +harebrained and preposterous, to make sense of the world. It is +constantly asking “Why?” and dreaming up excuses even if the question +has no answer. + +(There is probably an evolutionary reason that we evolved our split" +"(There is probably an evolutionary reason that we evolved our split + +brains. A seasoned CEO will often encourage his aides to take opposing +sides of an issue, to encourage thorough and thoughtful debate. +Oftentimes, the correct view emerges out of intense interaction with +incorrect ideas. Similarly, the two halves of the brain complement each +other, offering pessimistic/optimistic or analytical/holistic analysis of +the same idea. The two halves of the brain therefore play off each other. +Indeed, as we shall see, certain forms of mental illness may arise when +this interplay between the two brains goes awry.)" +"Now that we have a working theory of consciousness, the time has come +to utilize it to understand how neuroscience will evolve in the future. +There is a vast and remarkable set of experiments now being done in +neuroscience that are fundamentally altering the entire scientific +landscape. Using the power of electromagnetism, scientists can now +probe people’s thoughts, send telepathic messages, telekinetically control +objects around us, record memories, and perhaps enhance our +intelligence. + +Perhaps the most immediate and practical application of this new +technology is something once considered to be hopelessly impossible: +telepathy. + + BOOK II MIND OVER MATTER + +The brain, like it or not, is a machine. Scientists have come to +that conclusion, not because they are mechanistic killjoys, but +because they have amassed evidence that every aspect of +consciousness can be tied to the brain. + +—STEVEN PINKER + +3 TELEPATHY A PENNY FOR YOUR THOUGHTS" +"—STEVEN PINKER + +3 TELEPATHY A PENNY FOR YOUR THOUGHTS + +Harry Houdini, some historians believe, was the greatest magician +who ever lived. His breathtaking escapes from locked, sealed chambers +and death-defying stunts left audiences gasping. He could make people +disappear and then reemerge in the most unexpected places. And he +could read people’s minds. + +Or at least it seemed that way. + +Houdini took pains to explain that everything he did was an illusion, a +series of clever sleight-of-hand tricks. Mind reading, he would remind +people, was impossible. He was so outraged that unscrupulous magicians +would cheat wealthy patrons by performing cheap parlor tricks and +seances that he even went around the country exposing fakes by +pledging he could duplicate any feat of mind reading performed by these +charlatans. He was even on a committee organized by Scientific American +that offered a generous reward to anyone who could positively prove +they had psychic power. (No one ever picked up the reward.)" +"Houdini believed that telepathy was impossible. But science is proving +Houdini wrong. + +Telepathy is now the subject of intense research at universities around +the world, where scientists have already been able to use advanced +sensors to read individual words, images, and thoughts in a person’s +brain. This could alter the way we communicate with stroke and +accident victims who are “locked in” their bodies, unable to articulate +their thoughts except through blinks. But that’s just the start. Telepathy +might also radically change the way we interact with computers and the +outside world. + +Indeed, in a recent “Next 5 in 5 Forecast,” which predicts five +revolutionary developments in the next five years, IBM scientists claimed +that we will be able to mentally communicate with computers, perhaps + + replacing the mouse and voice commands. This means using the power +of the mind to call people on the phone, pay credit card bills, drive cars," +"make appointments, create beautiful symphonies and works of art, etc. +The possibilities are endless, and it seems that everyone—from computer +giants, educators, video game companies, and music studios to the +Pentagon—is converging on this technology." +"True telepathy, found in science-fiction and fantasy novels, is not +possible without outside assistance. As we know, the brain is electrical. +In general, anytime an electron is accelerated, it gives off +electromagnetic radiation. The same holds true for electrons oscillating +inside the brain, which broadcasts radio waves. But these signals are too +faint to be detected by others, and even if we could perceive these radio +waves, it would be difficult to make sense of them. Evolution has not +given us the ability to decipher this collection of random radio signals, +but computers can. Scientists have been able to get crude +approximations of a person’s thoughts using EEG scans. Subjects would +put on a helmet with EEG sensors and concentrate on certain pictures— +say, the image of a car. The EEG signals were then recorded for each +image and eventually a rudimentary dictionary of thought was created, +with a one-to-one correspondence between a person’s thoughts and the" +"with a one-to-one correspondence between a person’s thoughts and the +EEG image. Then, when a person was shown a picture of another car, +the computer would recognize the EEG pattern as being from a car." +"The advantage of EEG sensors is that they are noninvasive and quick. +You simply put a helmet containing many electrodes onto the surface of +the brain and the EEG can rapidly identify signals that change every +millisecond. But the problem with EEG sensors, as we have seen, is that +electromagnetic waves deteriorate as they pass through the skull, and it +is difficult to locate their precise source. This method can tell if you are +thinking of a car or a house, but it cannot re-create an image of the car. +That is where Dr. Jack Gallant’s work comes in. + +VIDEOS OF THE MIND + +The epicenter for much of this research is the University of California at +Berkeley, where I received my own Ph.D. in theoretical physics years +ago. I had the pleasure of touring the laboratory of Dr. Gallant, whose +group has accomplished a feat once considered to be impossible: +videotaping people’s thoughts. “This is a major leap forward + +reconstructing internal imagery. We are opening a window into the" +"reconstructing internal imagery. We are opening a window into the + + movies in our mind,” says Gallant. + +When I visited his laboratory, the first thing I noticed was the team of +young, eager postdoctoral and graduate students huddled in front of +their computer screens, looking intently at video images that were +reconstructed from someone’s brain scan. Talking to Gallant’s team, you +feel as though you are witnessing scientific history in the making." +"Gallant explained to me that first the subject lies flat on a stretcher, +which is slowly inserted headfirst into a huge, state-of-the-art MRI +machine, costing upward of $3 million. The subject is then shown +several movie clips (such as movie trailers readily available on +YouTube). To accumulate enough data, the subject has to sit motionless +for hours watching these clips, a truly arduous task. I asked one of the +postdocs, Dr. Shinji Nishimoto, how they found volunteers who were +willing to lie still for hours on end with only fragments of video footage +to occupy the time. He said the people in the room, the grad students +and postdocs, volunteered to be guinea pigs for their own research." +"As the subject watches the movies, the MRI machine creates a 3-D +image of the blood flow within the brain. The MRI image looks like a +vast collection of thirty thousand dots, or voxels. Each voxel represents a +pinpoint of neural energy, and the color of the dot corresponds to the +intensity of the signal and blood flow. Red dots represent points of large +neural activity, while blue dots represent points of less activity. (The +final image looks very much like thousands of Christmas lights in the +shape of the brain. Immediately you can see that the brain is +concentrating most of its mental energy in the visual cortex, which is +located at the back of the brain, while watching these videos.)" +"Gallant’s MRI machine is so powerful it can identify two to three +hundred distinct regions of the brain and, on average, can take snapshots +that have one hundred dots per region of the brain. (One goal for future +generations of MRI technology is to provide an even sharper resolution +by increasing the number of dots per region of the brain.) + +At first, this 3-D collection of colored dots looks like gibberish. But +after years of research, Dr. Gallant and his colleagues have developed a +mathematical formula that begins to find relationships between certain +features of a picture (edges, textures, intensity, etc.) and the MRI voxels. +For example, if you look at a boundary, you’ll notice it’s a region" +"separating lighter and darker areas, and hence the edge generates a +certain pattern of voxels. By having subject after subject view such a +large library of movie clips, this mathematical formula is refined, +allowing the computer to analyze how all sorts of images are converted +into MRI voxels. Eventually the scientists were able to ascertain a direct + + correlation between certain MRI patterns of voxels and features within +each picture." +"correlation between certain MRI patterns of voxels and features within +each picture. + +At this point, the subject is then shown another movie trailer. The +computer analyzes the voxels generated during this viewing and re¬ +creates a rough approximation of the original image. (The computer +selects images from one hundred movie clips that most closely resemble +the one that the subject just saw and then merges images to create a +close approximation.) In this way, the computer is able to create a fuzzy +video of the visual imagery going through your mind. Dr. Gallant’s +mathematical formula is so versatile that it can take a collection of MRI +voxels and convert it into a picture, or it can do the reverse, taking a +picture and then converting it to MRI voxels." +"I had a chance to view the video created by Dr. Gallant’s group, and it +was very impressive. Watching it was like viewing a movie with faces, +animals, street scenes, and buildings through dark glasses. Although you +could not see the details within each face or animal, you could clearly +identify the kind of object you were seeing." +"Not only can this program decode what you are looking at, it can also +decode imaginary images circulating in your head. Let’s say you are +asked to think of the Mona Lisa. We know from MRI scans that even +though you’re not viewing the painting with your eyes, the visual cortex +of your brain will light up. Dr. Gallant’s program then scans your brain +while you are thinking of the Mona Lisa and flips through its data files of +pictures, trying to find the closest match. In one experiment I saw, the +computer selected a picture of the actress Salma Hayek as the closest +approximation to the Mona Lisa. Of course, the average person can easily +recognize hundreds of faces, but the fact that the computer analyzed an +image within a person’s brain and then picked out this picture from +millions of random pictures at its disposal is still impressive." +"The goal of this whole process is to create an accurate dictionary that +allows you to rapidly match an object in the real world with the MRI +pattern in your brain. In general, a detailed match is very difficult and + +will take years, but some categories are actually easy to read just by +flipping through some photographs. Dr. Stanislas Dehaene of the College +de France in Paris was examining MRI scans of the parietal lobe, where +numbers are recognized, when one of his postdocs casually mentioned +that just by quickly scanning the MRI pattern, he could tell what number +the subject was looking at. In fact, certain numbers created distinctive +patterns on the MRI scan. He notes, “If you take 200 voxels in this area, +and look at which of them are active and which are inactive, you can +construct a machine-learning device that decodes which number is being +held in memory.”" +"This leaves open the question of when we might be able to have +picture-quality videos of our thoughts. Unfortunately, information is lost +when a person is visualizing an image. Brain scans corroborate this. +When you compare the MRI scan of the brain as it is looking at a flower +to an MRI scan as the brain is thinking about a flower, you immediately +see that the second image has far fewer dots than the first. So although +this technology will vastly improve in the coming years, it will never be +perfect. (I once read a short story in which a man meets a genie who +offers to create anything that the person can imagine. The man +immediately asks for a luxury car, a jet plane, and a million dollars. At +first, the man is ecstatic. But when he looks at these items in detail, he +sees that the car and the plane have no engines, and the image on the +cash is all blurred. Everything is useless. This is because our memories +are only approximations of the real thing.)" +"But given the rapidity with which scientists are beginning to decode +the MRI patterns in the brain, will we soon be able to actually read +words and thoughts circulating in the mind? + +READING THE MIND + +In fact, in a building next to Gallant’s laboratory, Dr. Brian Pasley and +his colleagues are literally reading thoughts—at least in principle. One of +the postdocs there, Dr. Sara Szczepanski, explained to me how they are +able to identify words inside the mind. + +The scientists used what is called ECOG (electrocorticogram) +technology, which is a vast improvement over the jumble of signals that + +EEG scans produce. ECOG scans are unprecedented in accuracy and +resolution, since signals are directly recorded from the brain and do not +pass through the skull. The flipside is that one has to remove a portion +of the skull to place a mesh, containing sixty-four electrodes in an eight- +by-eight grid, directly on top of the exposed brain." +"Luckily they were able to get permission to conduct experiments with +ECOG scans on epileptic patients, who were suffering from debilitating +seizures. The ECOG mesh was placed on the patients’ brains while open- +brain surgery was being performed by doctors at the nearby University +of California at San Francisco. + +As the patients hear various words, signals from their brains pass +through the electrodes and are then recorded. Eventually a dictionary is +formed, matching the word with the signals emanating from the + + electrodes in the brain. Later, when a word is uttered, one can see the +same electrical pattern. This correspondence also means that if one is +thinking of a certain word, the computer can pick up the characteristic +signals and identify it." +"With this technology, it might be possible to have a conversation that +takes place entirely telepathically. Also, stroke victims who are totally +paralyzed may be able to “talk” through a voice synthesizer that +recognizes the brain patterns of individual words. + +Not surprisingly, BMI (brain-machine interface) has become a hot +field, with groups around the country making significant breakthroughs. +Similar results were obtained by scientists at the University of Utah in +2011. They placed grids, each containing sixteen electrodes, over the +facial motor cortex (which controls movements of the mouth, lips, +tongue, and face) and Wernicke’s area, which processes information +about language." +"The person was then asked to say ten common words, such as “yes” +and “no,” “hot” and “cold,” “hungry” and “thirsty,” “hello” and “good¬ +bye,” and “more” and “less.” Using a computer to record the brain +signals when these words were uttered, the scientists were able to create +a rough one-to-one correspondence between spoken words and computer +signals from the brain. Later, when the patient voiced certain words, +they were able to correctly identify each one with an accuracy ranging +from 76 percent to 90 percent. The next step is to use grids with 121 +electrodes to get better resolution. + +In the future, this procedure may prove useful for individuals suffering +from strokes or paralyzing illnesses such as Lou Gehrig’s disease, who +would be able to speak using the brain-to-computer technique. + +TYPING WITH THE MIND" +"TYPING WITH THE MIND + +At the Mayo Clinic in Minnesota, Dr. Jerry Shih has hooked up epileptic +patients via ECOG sensors so they can learn how to type with the mind. +The calibration of this device is simple. The patient is first shown a +series of letters and is told to focus mentally on each symbol. A +computer records the signals emanating from the brain as it scans each +letter. As with the other experiments, once this one-to-one dictionary is +created, it is then a simple matter for the person to merely think of the +letter and for the letter to be typed on a screen, using only the power of +the mind. + +Dr. Shih, the leader of this project, says that the accuracy of his + + machine is nearly 100 percent. Dr. Shih believes that he can next create +a machine to record images, not just words, that patients conceive in +their minds. This could have applications for artists and architects, but +the big drawback of ECOG technology, as we have mentioned, is that it +requires opening up patients’ brains." +"Meanwhile, EEG typewriters, because they are noninvasive, are +entering the marketplace. They are not as accurate or precise as ECOG +typewriters, but they have the advantage that they can be sold over the +counter. Guger Technologies, based in Austria, recently demonstrated an +EEG typewriter at a trade show. According to their officials, it takes only +ten minutes or so for people to learn how to use this machine, and they +can then type at the rate of five to ten words per minute. + +TELEPATHIC DICTATION AND MUSIC + +The next step might be to transmit entire conversations, which could +rapidly speed up telepathic transmission. The problem, however, is that +it would require making a one-to-one map between thousands of words +and their EEG, MRI, or ECOG signals. But if one can, for example, +identify the brain signals of several hundred select words, then one" +"might be able to rapidly transmit words found in a common +conversation. This means that one would think of the words in entire +sentences and paragraphs of a conversation and a computer would print +them out. + +This could be extremely useful for journalists, writers, novelists, and +poets, who could simply think and have a computer take dictation. The +computer would also become a mental secretary. You would mentally +give instructions to the robo-secretary about a dinner, plane trip, or +vacation, and it would fill in all the details about the reservations." +"Not only dictation but also music may one day be transcribed in this +way. Musicians would simply hum a few melodies in their head and a +computer would print them out, in musical notation. To do this, you +would ask someone to mentally hum a series of notes, which would +generate certain electrical signals for each one. A dictionary would again +be created in this way, so that when you think of a musical note, the +computer would print it out in musical notation. + +In science fiction, telepaths often communicate across language +barriers, since thoughts are considered to be universal. However, this +might not be true. Emotions and feelings may well be nonverbal and +universal, so that one could telepathically send them to anyone, but + + rational thinking is so closely tied to language that it is very unlikely +that complex thoughts could be sent across language barriers. Words will +still be sent telepathically in their original language. + +TELEPATHY HELMETS" +"TELEPATHY HELMETS + +In science fiction, we also often encounter telepathy helmets. Put them +on, and—presto!—you can read other people’s minds. The U.S. Army, in +fact, has expressed interest in this technology. In a firefight, with +explosions going off and bullets whizzing overhead, a telepathy helmet +could be a lifesaver, since it can be difficult to communicate orders amid +the sound and fury of the battlefield. (I can personally testify to this. +Years ago, during the Vietnam War, I served in the U.S. Infantry at Fort +Benning, outside Atlanta, Georgia. During machine-gun training, the +sound of hand grenades and rounds of bullets going off on the battlefield +next to my ear was deafening; it was so intense I could not hear anything + +else. Later, there was a loud ringing in my ear that lasted for three full +days.) With a telepathy helmet, a soldier could mentally communicate +with his platoon amid all the thunder and noise." +"Recently, the army gave a $6.3 million grant to Dr. Gerwin Schalk at +Albany Medical College, but it knows that a fully functional telepathy +helmet is still years away. Dr. Schalk experiments with ECOG +technology, which, as we have seen, requires placing a mesh of +electrodes directly on top of the exposed brain. With this method, his +computers have been able to recognize vowels and thirty-six individual +words inside the thinking brain. In some of his experiments, he +approached 100 percent accuracy. But at present, this is still impractical +for the U.S. Army, since it requires removing part of the skull in the +clean, sterile environment of a hospital. And even then, recognizing +vowels and a handful of words is a far cry from sending urgent messages +to headquarters in a firefight. But his ECOG experiments have +demonstrated that it is possible to communicate mentally on the +battlefield." +"Another method is being explored by Dr. David Poeppel of New York +University. Instead of opening up the skulls of his subjects, he employs +MEG technology, using tiny bursts of magnetic energy rather than +electrodes to create electrical charges in the brain. Besides being +noninvasive, the advantage of MEG technology is that it can precisely +measure fleeting neural activity, in contrast to the slower MRI scans. In +his experiments, Poeppel has been able to successfully record electrical +activity in the auditory cortex when people think silently of a certain +word. But the drawback is that this recording still requires the use of + + large, table-size machines to generate a magnetic pulse. + +Obviously, one wants a method that is noninvasive, portable, and +accurate. Dr. Poeppel hopes his work with MEG technology will +complement the work being done using EEG sensors. But true telepathy +helmets are still many years away, because MEG and EEG scans lack +accuracy. + +MRI IN A CELL PHONE" +"MRI IN A CELL PHONE + +At present, we are hindered by the relatively crude nature of the existing + +instruments. But, as time goes by, more and more sophisticated +instruments will probe deeper into the mind. The next big breakthrough +may be MRI machines that are handheld." +"The reason why MRI machines have to be so huge right now is that +one needs a uniform magnetic field to get good resolution. The larger +the magnet, the more uniform one can make the field, and the better +accuracy one finds in the final pictures. However, physicists know the +exact mathematical properties of magnetic fields (they were worked out +by physicist James Clerk Maxwell back in the 1860S). In 1993 in +Germany, Dr. Bernhard Bliimich and his colleagues created the world’s +smallest MRI machine, which is the size of a briefcase. It uses a weak +and distorted magnetic field, but supercomputers can analyze the +magnetic field and correct for this so that the device produces realistic 3- +D pictures. Since computer power doubles roughly every two years, they +are now powerful enough to analyze the magnetic field created by the +briefcase-sized device and compensate for its distortion." +"As a demonstration of their machine, in 2006 Dr. Bliimich and his +colleagues were able to take MRI scans of Otzi, the “Iceman,” who was +frozen in ice about 5,300 years ago toward the end of the last ice age. +Because Otzi was frozen in an awkward position, with his arms spread +apart, it was difficult to cram him inside the small cylinder of a +conventional MRI machine, but Dr. Bliimich’s portable machine easily +took MRI photographs. + +These physicists estimate that, with increasing computer power, an +MRI machine of the future might be the size of a cell phone. The raw +data from this cell phone would be sent wirelessly to a supercomputer, +which would process the data from the weak magnetic field and then +create a 3-D image. (The weakness of the magnetic field is compensated +for by the increase in computer power.) This then could vastly accelerate +research. “Perhaps something like the Star Trek tricorder is not so far off" +"after all,” Dr. Bliimich has said. (The tricorder is a small, handheld +scanning device that gives an instant diagnosis of any illness.) In the +future, you may have more computer power in your medicine cabinet +than there is in a modern university hospital today. Instead of waiting to +get permission from a hospital or university to use an expensive MRI +machine, you could gather data in your own living room by simply +waving the portable MRI over yourself and then e-mailing the results to + +a lab for analysis." +"a lab for analysis. + +It could also mean that, at some point in the future, an MRI telepathy +helmet might be possible, with vastly better resolution than an EEG +scan. Here is how it may work in the coming decades. Inside the helmet, +there would be electromagnetic coils to produce a weak magnetic field +and radio pulses that probe the brain. The raw MRI signals would then +be sent to a pocketsize computer placed in your belt. The information +would then be radioed to a server located far from the battlefield. The +final processing of the data would be done by a supercomputer in a +distant city. Then the message would be radioed back to your troops on +the battlefield. The troops would hear the message either through +speakers or through electrodes placed in the auditory cortex of their +brains. + +DARPA AND HUMAN ENHANCEMENT" +"DARPA AND HUMAN ENHANCEMENT + +Given the costs of all this research, it is legitimate to ask: Who is paying +for it? Private companies have only recently shown interest in this +cutting-edge technology, but it’s still a big gamble for many of them to +fund research that may never pay off. Instead, one of the main backers is +DARPA, the Pentagon’s Defense Advanced Research Projects Agency, +which has spearheaded some of the most important technologies of the +twentieth century. + +DARPA was originally set up by President Dwight Eisenhower after +the Russians sent Sputnik into orbit in 1957 and shocked the world. +Realizing that the United States might quickly be outpaced by the +Soviets in high technology, Eisenhower hastily established this agency to +keep the country competitive with the Russians. Over the years, the +numerous projects it started grew so large that they became independent +entities by themselves. One of its first spinoffs was NASA." +"DARPA’s strategic plan reads like something from science fiction: its +“only charter is radical innovation.” The only justification for its +existence is “to accelerate the future into being.” DARPA scientists are +constantly pushing the boundaries of what is physically possible. As + + former DARPA official Michael Goldblatt says, they try not to violate the +laws of physics, “or at least not knowingly. Or at least not more than one + +per program.”" +"per program.” + +But what separates DARPA from science fiction is its track record, +which is truly astounding. One of its early projects in the 1960s was +Arpanet, which was a war-fighting telecommunications network that +would electronically connect scientists and officials during and after +World War III. In 1989, the National Science Foundation decided that, in +light of the breakup of the Soviet bloc, it was unnecessary to keep it a +secret, so it declassified this hush-hush military technology and +essentially gave codes and blueprints away for free. Arpanet would +eventually become the Internet. + +When the U.S. Air Force needed a way to guide its ballistic missiles in +space, DARPA helped create Project 57, a top-secret project that was +designed to place H-bombs on hardened Soviet missile silos in a +thermonuclear exchange. It would later become the foundation for the +Global Positioning System (GPS). Instead of guiding missiles, today it +guides lost motorists." +"DARPA has been a key player in a series of inventions that have +altered the twentieth and twenty-first centuries, including cell phones, +night-vision goggles, telecommunications advances, and weather +satellites. I have had a chance to interact with DARPA scientists and +officials on several occasions. I once had lunch with one of the agency’s +former directors at a reception filled with many scientists and futurists. I +asked him a question that had always bothered me: Why do we have to +rely on dogs to sniff our luggage for the presence of high explosives? +Surely our sensors are sensitive enough to pick up the telltale signature +of explosive chemicals. He replied that DARPA had actively looked into +this same question but had come up against some severe technical +problems. The olfactory sensors of dogs, he said, had evolved over +millions of years to be able to detect a handful of molecules, and that +kind of sensitivity is extremely difficult to match, even with our most" +"kind of sensitivity is extremely difficult to match, even with our most +finely tuned sensors. It’s likely that we will continue to rely on dogs at +airports for the foreseeable future." +"On another occasion, a group of DARPA physicists and engineers came +to a talk I gave about the future of technology. Later I asked them if they +had any concerns of their own. One concern, they said, was their public +image. Most people have never heard of DARPA, but some link it to +dark, nefarious government conspiracies, everything from UFO cover- + + ups, Area 51, and Roswell to weather control, etc. They sighed. If only +these rumors were true, they could certainly use help from alien +technology to jump-start their research!" +"With a budget of $3 billion, DARPA has now set its sights on the +brain-machine interface. When discussing the potential applications, +former DARPA official Michael Goldblatt pushes the boundary of the +imagination. He says, “Imagine if soldiers could communicate by +thought alone.... Imagine the threat of biological attack being +inconsequential. And contemplate, for a moment, a world in which +learning is as easy as eating, and the replacement of damaged body parts +as convenient as a fast-food drive-through. As impossible as these visions +sound or as difficult as you might think the task would be, these visions +are the everyday work of the Defense Sciences Office [a branch of +DARPA].”" +"Goldblatt believes that historians will conclude that the long-term +legacy of DARPA will be human enhancement, “our future historical +strength.” He notes that the famous army slogan “Be All You Can Be” +takes on a new meaning when contemplating the implications of human +enhancement. Perhaps it is no accident that Michael Goldblatt is pushing +human enhancement so vigorously at DARPA. His own daughter suffers +from cerebral palsy and has been confined to a wheelchair all her life. +Since she requires outside help, her illness has slowed her down, but she +has always risen above adversity. She is going to college and dreaming +of starting her own company. Goldblatt acknowledges that his daughter +is his inspiration. As Washington Post editor Joel Garreau has noted, +“What he is doing is spending untold millions of dollars to create what +might well be the next step in human evolution. And yet, it has occurred +to him that the technology he is helping create might someday allow his" +"to him that the technology he is helping create might someday allow his +daughter not just to walk, but to transcend.”" +"PRIVACY ISSUES + +When hearing of mind-reading machines for the first time, the average +person might be concerned about privacy. The idea that a machine +concealed somewhere may be reading our intimate thoughts without our +permission is unnerving. Human consciousness, as we have stressed, + +involves constantly running simulations of the future. In order for these +simulations to be accurate, we sometimes imagine scenarios that wade +into immoral or illegal territory, but whether or not we act on these +plans, we prefer to keep them private. + +For scientists, life would be easier if they could simply read people’s + + thoughts from a distance using portable devices (rather than by using +clumsy helmets or surgically opening up the skull), but the laws of +physics make this exceedingly difficult." +"When I asked Dr. Nishimoto, who works in Dr. Gallant’s Berkeley lab, +about the question of privacy, he smiled and replied that radio signals +degrade quite rapidly outside the brain, so these signals would be too +diffuse and weak to make any sense to anyone standing more than a few +feet away. (In school, we learned about Newton’s laws and that gravity +diminishes as the square of the distance, so that if you doubled your +distance from a star, the gravity field diminishes by a factor of four. But +magnetic fields diminish much faster than the square of the distance. +Most signals decrease by the cube or quartic of the distance, so if you +double the distance from an MRI machine, the magnetic field goes down +by a factor of eight or more.)" +"Furthermore, there would be interference from the outside world, +which would mask the faint signals coming from the brain. This is one +reason why scientists require strict laboratory conditions to do their +work, and even then they are able to extract only a few letters, words, or +images from the thinking brain at any given time. The technology is not +adequate to record the avalanche of thoughts that often circulate in our +brain as we simultaneously consider several letters, words, phrases, or +sensory information, so using these devices for mind reading as seen in +the movies is not possible today, and won’t be for decades to come." +"For the foreseeable future, brain scans will continue to require direct +access to the human brain in laboratory conditions. But in the highly +unlikely event that someone in the future finds a way to read thoughts +from a distance, there are still countermeasures you can take. To keep +your most important thoughts private, you might use a shield to block +brain waves from entering the wrong hands. This can be done with +something called a Faraday cage, invented by the great British physicist +Michael Faraday in 1836, although the effect was first observed by +Benjamin Franklin. Basically, electricity will rapidly disperse around a" +"metal cage, such that the electric field inside the cage is zero. To +demonstrate this, physicists (like myself) have entered a metallic cage on +which huge electrical bolts are fired. Miraculously, we are unscratched. +This is why airplanes can be hit by lightning bolts and not suffer +damage, and why cable wires are covered with metallic threads. +Similarly, a telepathy shield would consist of thin metal foil placed +around the brain. + +TELEPATHY VIA NANOPROBES IN THE BRAIN" +"TELEPATHY VIA NANOPROBES IN THE BRAIN + + There is another way to partially solve the privacy issue, as well as the +difficulty of placing ECOG sensors into the brain. In the future, it may be +possible to exploit nanotechnology, the ability to manipulate individual +atoms, to insert a web of nanoprobes into the brain that can tap into +your thoughts. These nanoprobes might be made of carbon nanotubes, +which conduct electricity and are as thin as the laws of atomic physics +allow. These nanotubes are made of individual carbon atoms arrayed in +a tube a few molecules thick. (They are the subject of intense scientific +interest, and are expected in the coming decades to revolutionize the +way scientists probe the brain.)" +"The nanoprobes would be placed precisely in those areas of the brain +devoted to certain activities. In order to convey speech and language, +they would be placed in the left temporal lobes. In order to process +visual images, they would be placed in the thalamus and visual cortex. +Emotions would be sent via nanoprobes in the amygdala and limbic +system. The signals from these nanoprobes would be sent to a small +computer, which would process the signals and wirelessly send +information to a server and then the Internet. + +Privacy issues would be partially solved, since you would completely +control when your thoughts are being sent over cables or the Internet. +Radio signals can be detected by any bystander with a receiver, but +electrical signals sent along a cable cannot. The problem of opening up +the skull to use messy ECOG meshes is also solved, because the +nanoprobes can be inserted via microsurgery." +"Some science-fiction writers have conjectured that when babies are +born in the future, these nanoprobes might be painlessly implanted, so + +that telepathy becomes a way of life for them. In Star Trek, for example, +implants are routinely placed into the children of the Borg at birth so +that they can telepathically communicate with others. These children +cannot imagine a world where telepathy does not exist. They take it for +granted that telepathy is the norm. + +Because these nanoprobes are tiny, they would be invisible to the +outside world, so there would be no social ostracism. Although society +might be repulsed at the idea of inserting probes permanently into the +brain, these science-fiction writers assume that people will get used to +the idea because the nanoprobes would be so useful, just like test-tube +babies have been accepted by society today after the initial controversy +surrounding them. + +LEGAL ISSUES" +"LEGAL ISSUES + + For the foreseeable future, the question is not whether someone will be +able to read our thoughts secretly from a remote, concealed device, but +whether we will willingly allow our thoughts to be recorded. What +happens, then, if some unscrupulous person gets unauthorized access to +those files? This raises the issue of ethics, since we would not want our +thoughts to be read against our will. Dr. Brian Pasley says, “There are +ethical concerns, not with the current research, but with the possible +extensions of it. There has to be a balance. If we are somehow able to +decode someone’s thoughts instantaneously that might have great +benefits for the thousands of severely disabled people who are unable to +communicate right now. On the other hand, there are great concerns if +this were applied to people who didn’t want that.”" +"Once it becomes possible to read people’s minds and make recordings, +a host of other ethical and legal questions will arise. This happens +whenever any new technology is introduced. Historically it often takes +years before the law is fully able to address their implications. + +For instance, copyright laws may have to be rewritten. What happens +if someone steals your invention by reading your thoughts? Can you +patent your thoughts? Who actually owns the idea? + +Another problem occurs if the government is involved. As John Perry +Barlow, poet and lyricist for the Grateful Dead, once said, “Relying on" +"the government to protect your privacy is like asking a peeping tom to +install your window blinds.” Would the police be allowed to read your +thoughts when you are being interrogated? Already courts have been +ruling on cases where an alleged criminal refused to submit his DNA as +evidence. In the future, will the government be allowed to read your +thoughts without your consent, and if so, will they be admissible in +court? How reliable would they be? In the same way that MRI lie +detectors measure only increased brain activity, it’s important to note +that thinking about a crime and actually committing one are two +different things. During cross-examination, a defense lawyer might argue +that these thoughts were just random musings and nothing more." +"Another gray area concerns the rights of people who are paralyzed. If +they are drafting a will or legal document, can a brain scan be sufficient +to create a legal document? Assume that a totally paralyzed person has a +sharp, active mind and wants to sign a contract or manage his funds. Are +these documents legal, given that the technology may not be perfect? + +There is no law of physics that can resolve these ethical questions. +Ultimately, as this technology matures, these issues will have to be + + settled in court by judges and juries." +"settled in court by judges and juries. + +Meanwhile, governments and corporations might have to invent new +ways to prevent mental espionage. Industrial espionage is already a +multimillion-dollar industry, with governments and corporations +building expensive “safe rooms” that have been scanned for bugs and +listening devices. In the future (assuming that a method can be devised +to listen to brain waves from a distance), safe rooms may have to be +designed so that brain signals are not accidentally leaked to the outside +world. These safe rooms would be surrounded by metallic walls, which +would form a Faraday cage shielding the interior of the room from the +outside world." +"Every time a new form of radiation has been exploited, spies have +tried to use it for espionage, and brain waves are probably no exception. +The most famous case involved a tiny microwave device hidden in the +Great Seal of the United States in the U.S. embassy in Moscow. From +1945 until 1952, it was transmitting top-secret messages from U.S. +diplomats directly to the Soviets. Even during the Berlin Crisis of 1948 +and the Korean War, the Soviets used this bug to decipher what the +United States was planning. It might have continued to leak secrets even" +"today, changing the course of the Cold War and world history, but it was +accidentally discovered when a British engineer heard secret +conversations on an open radio band. U.S. engineers were shocked when +they picked apart the bug; they failed to detect it for years because it +was passive, requiring no energy source. (The Soviets cleverly evaded +detection because the bug was energized by microwave beams from a +remote source.) It is possible that future espionage devices will be made +to intercept brain waves as well. + +Although much of this technology is still primitive, telepathy is slowly +becoming a fact of life. In the future, we may interact with the world via +the mind. But scientists want to go beyond just reading the mind, which +is passive. They want to take an active role—to move objects with the +mind. Telekinesis is a power usually ascribed to the gods. It is the divine +power to shape reality to your wishes. It is the ultimate expression of our +thoughts and desires." +"We will soon have it. + +It is the business of the future to be dangerous.... The major +advances in civilization are processes that all but wreck the +societies in which they occur. + + —ALFRED NORTH WHITEHEAD + +4 TELEKINESIS MIND CONTROLLING MATTER + +Cathy Hutchinson is trapped inside her body. + +She was paralyzed fourteen years ago by a massive stroke. A +quadriplegic, she is like thousands of “locked-in” patients who have lost +control over most of their muscles and bodily functions. Most of the day, +she lies helpless, requiring continual nursing care, yet her mind is clear. +She is a prisoner in her own body." +"But in May 2012, her fortunes changed radically. Scientists at Brown +University placed a tiny chip on top of her brain, called Braingate, which +is connected by wires to a computer. Signals from her brain are relayed +through the computer to a mechanical robotic arm. By simply thinking, +she gradually learns to control the motion of the arm so that it can, for +instance, grab a bottled drink and bring it to her mouth. For the first +time, she is able to have some control of the world around her." +"Because she is paralyzed and cannot talk, she had to communicate her +excitement by making eye movements. A device tracks her eyes and then +translates her movements into a typed message. When she was asked +how she felt, after years of being imprisoned inside a shell called her +body, she replied, “Ecstatic!” Looking forward to the day when her other +limbs are connected to her brain via computer, she added, “I would love +to have a robotic leg support.” Before her stroke, she loved to cook and +tend her garden. “I know that someday this will happen again,” she +added. At the rate at which the field of cyber prosthetics is moving, she +might have her wish soon." +"Professor John Donoghue and his colleagues at Brown University and +also at the University of Utah have created a tiny sensor that acts like a +bridge to the outside world for those who can no longer communicate. +When I interviewed him, he told me, “We have taken a tiny sensor, the +size of a baby aspirin, or four millimeters, and implanted it onto the +surface of the brain. Because of ninety-six little ‘hairs’ or electrodes that +pick up brain impulses, it can pick up signals of your intention to move + +your arm. We target the arm because of its importance.” Because the +motor cortex has been carefully mapped over the decades, it is possible +to place the chip directly on top of the neurons that control specific +limbs." +"The key to Braingate lies in translating neural signals from the chip +into meaningful commands that can move objects in the real world, +starting with the cursor of a computer screen. Donoghue told me that he +does this by asking the patient to imagine moving the cursor of a +computer screen in a certain way, e.g., moving it to the right. It takes +only a few minutes to record the brain signals corresponding to this task. +In this way, the computer recognizes that whenever it detects a brain +signal like that, it should move the cursor to the right. + +Then, whenever that person thinks of moving the cursor to the right, +the computer actually moves the cursor in that direction. In this way, +there is a one-to-one map between certain actions that the patient +imagines and the actual action itself. A patient can immediately start to +control the movement of the cursor, practically on the first try." +"Braingate opens the door to a new world of neuroprosthetics, allowing +a paralyzed person to move artificial limbs with the mind. In addition, it +lets the patient communicate directly with their loved ones. The first +version of this chip, tested in 2004, was designed so that paralyzed +patients could communicate with a laptop computer. Soon afterward, +these patients were surfing the web, reading and writing e-mails, and +controlling their wheelchairs. + +More recently, the cosmologist Stephen Hawking had a +neuroprosthetic device attached to his glasses. Like an EEG sensor, it can +connect his thoughts to a computer so that he can maintain some contact +with the outside world. It is rather primitive, but eventually devices +similar to it will become much more sophisticated, with more channels +and greater sensitivity." +"All this, Dr. Donoghue told me, could have a profound impact on the +lives of these patients: “Another useful thing is that you can connect this +computer to any device—a toaster, a coffee maker, an air conditioner, a +light switch, a typewriter. It’s really quite easy to do these things these +days, and it’s very inexpensive. For a quadriplegic who can’t get around, +they will be able to change the TV channel, turn the lights on, and do all +those things without anybody coming into the room and doing it for + +them.” Eventually, they will be able to do anything a normal person can +do, via computers. + +FIXING SPINAL CORD INJURIES + +A number of other groups are entering the fray. Another breakthrough +was made by scientists at Northwestern University who have connected" +"a monkey’s brain directly to his own arm, bypassing an injured spinal +cord. In 1995, there was the sad story of Christopher Reeve, who soared +into outer space in the Superman movies but was completely paralyzed +due to an injury to his spinal cord. Unfortunately, he was thrown off a +horse and landed on his neck, so the spinal cord was damaged just +beneath his head. If he had lived longer, he might have seen the work of +scientists who want to use computers to replace broken spinal cords. In +the United States alone, more than two hundred thousand people have +some form of spinal cord injury. In an earlier age, these individuals +might have died soon after the accident, but because of advances in +acute trauma care, the number of people who survive these sorts of +injuries has actually grown in recent years. We are also haunted by the +images of thousands of wounded warriors who were victims of roadside +bombs in Iraq and Afghanistan. And if you include the number of" +"bombs in Iraq and Afghanistan. And if you include the number of +patients paralyzed by strokes and other illnesses, like amyotropic lateral +sclerosis (ALS), the number of patients swells to two million." +"The scientists at Northwestern used a one-hundred-electrode chip, +which was placed directly on the brain of a monkey. The signals from +the brain were carefully recorded as the monkey grasped a ball, lifted it, +and released it into a tube. Since each task corresponds to a specific +firing of neurons, the scientists could gradually decode these signals. + +When the monkey wanted to move his arm, the signals were processed +by a computer using this code, and, instead of sending the messages to a +mechanical arm, they sent the signals directly to the nerves of the +monkey’s real arm. “We are eavesdropping on the natural electrical +signals from the brain that tell the arm and hand how to move, and +sending those signals directly to the muscles,” says Dr. Lee Miller. + +By trial and error, the monkey learned to coordinate the muscles in his +arm. “There is a process of motor learning that is very similar to the" +"process you go through when you learn to use a new computer, mouse, +or a different tennis racquet,” adds Dr. Miller. + +(It is remarkable that the monkey was able to master so many motions +of his arm, given the fact that there are only one hundred electrodes on +this brain chip. Dr. Miller points out that millions of neurons are +involved in controlling the arm. The reason that one hundred electrodes +can give a reasonable approximation to the output of millions of neurons +is that the chip connects to the output neurons, after all the complex +processing has already been done by the brain. With the sophisticated +analysis out of the way, the one hundred electrodes are responsible +simply for feeding that information to the arm.) + +This device is one of several being devised at Northwestern that will" +"This device is one of several being devised at Northwestern that will + + allow patients to bypass their injured spinal cords. Another neural +prosthesis uses the motion of the shoulders to control the arm. An +upward shrug causes the hand to close. A downward shrug causes the +hand to open. The patient also has the ability to curl his fingers around +an object like a cup, or manipulate a key that is grasped between the +thumb and index finger. + +Dr. Miller concludes, “This connection from brain to muscles might +someday be used to help patients paralyzed due to spinal cord injury +perform activities of daily living and achieve greater independence.” + +REVOLUTIONIZING PROSTHETICS" +"REVOLUTIONIZING PROSTHETICS + +Much of the funding driving these remarkable developments comes from +a DARPA project called Revolutionizing Prosthetics, a $150 million +effort that has been bankrolling these efforts since 2006. One of the +driving forces behind Revolutionizing Prosthetics is retired U.S. Army +colonel Geoffrey Ling, who is a neurologist with several tours of duty in +Iraq and Afghanistan. He was appalled at the human carnage he +witnessed on the battlefield caused by roadside bombs. In previous wars, +many of these brave service members would have died on the spot. But +today, with helicopters and an extensive medical evacuation +infrastructure, many of them survive but still suffer from serious bodily +injuries. More than 1,300 service members have lost limbs after coming +back from the Middle East." +"Dr. Ling asked himself whether there was a scientific way to replace +these lost limbs. Backed by funding from the Pentagon, he asked his staff +to come up with concrete solutions within five years. When he made that +request, he was met with incredulity. He recalled, “They thought we +were crazy. But it’s in insanity that things happen.” + +Spurred into action by Dr. Ling’s boundless enthusiasm, his crew has +created miracles in the laboratory. For example, Revolutionary +Prosthetics funded scientists at the Johns Hopkins Applied Physics +Laboratory who have created the most advanced mechanical arm on +Earth, which can duplicate nearly all the delicate motions of the fingers, +hand, and arm in three dimensions. It is the same size and has the same +strength and agility as a real arm. Although it is made of steel, if you +covered it up with flesh-colored plastic, it would be nearly +indistinguishable from a real arm." +"This arm was attached to Jan Sherman, a quadriplegic who had +suffered from a genetic disease that damaged the connection between +her brain and her body, leaving her completely paralyzed from the neck + + down. At the University of Pittsburgh, electrodes were placed directly on +top of her brain, which were then connected to a computer and then to a +mechanical arm. Five months after surgery to attach the arm, she +appeared on 60 Minutes. Before a national audience, she cheerfully used +her new arm to wave, greet the host, and shake his hand. She even gave +him a fist bump to show how sophisticated the arm was. + +Dr. Ling says, “In my dream, we will be able to take this into all sorts +of patients, patients with strokes, cerebral palsy, and the elderly.” + +TELEKINESIS IN YOUR LIFE" +"TELEKINESIS IN YOUR LIFE + +Not only scientists but also entrepreneurs are looking at brain-machine +interface (BMI). They wish to incorporate many of these dazzling +inventions as a permanent part of their business plans. BMI has already +penetrated the youth market, in the form of video games and toys that +use EEG sensors so that you can control objects with the mind in both +virtual reality and the real world. In 2009, NeuroSky marketed the first +toy, Mindflex, specifically designed to use EEG sensors to move a ball +through a maze. Concentrating while wearing the Mindflex EEG device + +increases the speed of a fan within the maze and propels a tiny ball +down a pathway." +"increases the speed of a fan within the maze and propels a tiny ball +down a pathway. + +Mind-controlled video games are also blossoming. Seventeen hundred +software developers are working with NeuroSky, many of them on the +company’s $129 million Mindwave Mobile headset. These video games +use a small, portable EEG sensor wrapped around your forehead that +allows you to navigate in virtual reality, where the movements of your +avatar are controlled mentally. As you maneuver your avatar on the +video screen, you can fire weapons, evade enemies, rise to new levels, +score points, etc., as in an ordinary video game, except that everything is +hands-free. + +“There’s going to be a whole ecosystem of new players, and NeuroSky +is very well positioned to be like the Intel of this new industry,” claims +Alvaro Fernandez of SharpBrains, a market research firm." +"Besides firing virtual weapons, the EEG helmet can also detect when +your attention begins to flatten out. NeuroSky has been getting inquiries +from companies concerned about injuries to workers who lose +concentration while operating a dangerous machine or who fall asleep at +the wheel. This technology could be a lifesaver, alerting the worker or +driver that he is losing his focus. The EEG helmet would set off an alarm +when the wearer dozes off. (In Japan, this headset is already creating a + + fad among partygoers. The EEG sensors look like cat ears when you put +them on your head. The ears suddenly rise when your attention is +focused and then flatten out when it fades. At parties, people can express +romantic interest just by thinking, so you know if you are impressing +someone.)" +"But perhaps the most novel applications of this technology are being +pursued by Dr. Miguel Nicolelis of Duke University. When I interviewed +him, he told me that he thinks he can duplicate many of the devices +found only in science fiction. + +SMART HANDS AND MIND MELDS + +Dr. Nicolelis has shown that this brain-machine interface can be done +across continents. He places a monkey on a treadmill. A chip is +positioned on the monkey’s brain, which is connected to the Internet. On + +the other side of the planet, in Kyoto, Japan, signals from the monkey +are used to control a robot that can walk. By walking on the treadmill in +North Carolina, the monkey controls a robot in Japan, which executes +the same walking motion. Using only his brain sensors and the reward of +a food pellet, Dr. Nicolelis has trained these monkeys to control a +humanoid robot called CB-1 halfway around the world." +"He is also tackling one of the main problems with brain-machine +interface: the lack of feeling. Today’s prosthetic hands don’t have a sense +of touch, and hence they feel foreign; because there’s no feedback, they +might accidentally crush someone’s fingers while engaging in a +handshake. Picking up an eggshell with a mechanical arm would be +nearly impossible. + +Nicolelis hopes to circumvent this problem by having a direct brain-to- +brain interface. Messages would be sent from the brain to a mechanical +arm that has sensors, which would then send messages directly back to +the brain, thereby bypassing the stem altogether. This brain-machine- +brain interface (BMBI) could enable a clean, direct feedback mechanism +to allow for the sensation of touch." +"Dr. Nicolelis started by connecting the motor cortex of rhesus monkeys +to mechanical arms. These mechanical arms have sensors on them, +which then send signals back to the brain by electrodes connected to the +somatosensory cortex (which registers the sensation of touch). The +monkeys were given a reward after every successful trial; they learned +how to use this apparatus within four to nine trials. + + To do this, Dr. Nicolelis had to invent a new code that would +represent different surfaces (which were rough or smooth). “After a +month of practice,” he told me, “this part of the brain learns this new +code, and starts to associate this new artificial code that we created with +different textures. So this is the first demonstration that we can create a +sensory channel” that can simulate sensations of the skin." +"I mentioned to him that this idea sounds like the “holodeck” of Star +Trek, where you wander in a virtual world but feel sensations when you +bump into virtual objects, just as if they were real. This is called “haptic +technology,” which uses digital technology to simulate the sense of +touch. Nicolelis replied, “Yes, I think this is the first demonstration that +something like the holodeck will be possible in the near future.” + +The holodeck of the future might use a combination of two + +technologies. First, people in the holodeck would wear Internet contact +lenses, so that they would see an entirely new virtual world everywhere +they looked. The scenery in your contact lens would change instantly +with the push of a button. And if you touched any object in this world, +signals sent into the brain would simulate the sensation of touch, using +BMBI technology. In this way, objects in the virtual world you see inside +your contact lens would feel solid." +"Brain-to-brain interface would make possible not only haptic +technology, but also an “Internet of the mind,” or brain-net, with direct +brain-to-brain contact. In 2013, Dr. Nicolelis was able to accomplish +something straight out of Star Trek, a “mind meld” between two brains. +He started with two groups of rats, one at Duke University, the other in +Natal, Brazil. The first group learned to press a lever when seeing a red +light. The second group learned to press a lever when their brains were +stimulated by a signal sent via an implant. Their reward for pressing the +lever was a sip of water. Then Dr. Nicolelis connected the motor cortices +of the brains of both groups via a fine wire through the Internet." +"When the first group of rats saw the red light, a signal was sent over +the Internet to Brazil to the second group, which then pressed the lever. +In seven out of ten trials, the second group of rats correctly responded to +the signals sent by the first group. This was the first demonstration that +signals could be transferred and also interpreted correctly between two +brains. It’s still a far cry from the mind meld of science fiction, where +two minds merge into one, because this is still primitive and the sample +size is small, but it is a proof of principle that a brain-net might be +possible. + +In 2013, the next important step was taken when scientists went +beyond animal studies and demonstrated the first direct human brain-to- + + brain communication, with one human brain sending a message to +another via the Internet." +"brain communication, with one human brain sending a message to +another via the Internet. + +This milestone was achieved at the University of Washington, with +one scientist sending a brain signal (move your right arm) to another +scientist. The first scientist wore an EEG helmet and played a video +game. He fired a cannon by imagining moving his right arm, but was +careful not to move it physically. + +The signal from the EEG helmet was sent over the Internet to another +scientist, who was wearing a transcranial magnetic helmet carefully + +placed over the part of his brain that controlled his right arm. When the +signal reached the second scientist, the helmet would send a magnetic +pulse into his brain, which made his right arm move involuntarily, all by +itself. Thus, by remote control, one human brain could control the +movement of another." +"This breakthrough opens up a number of possibilities, such as +exchanging nonverbal messages via the Internet. You might one day be +able to send the experience of dancing the tango, bungee jumping, or +skydiving to the people on your e-mail list. Not just physical activity, but +emotions and feelings as well might be sent via brain-to-brain +communication." +"Nicolelis envisions a day when people all over the world could +participate in social networks not via keyboards, but directly through +their minds. Instead of just sending e-mails, people on the brain-net +would be able to telepathically exchange thoughts, emotions, and ideas +in real time. Today a phone call conveys only the information of the +conversation and the tone of voice, nothing more. Video conferencing is +a bit better, since you can read the body language of the person on the +other end. But a brain-net would be the ultimate in communications, +making it possible to share the totality of mental information in a +conversation, including emotions, nuances, and reservations. Minds +would be able to share their most intimate thoughts and feelings. + +TOTAL IMMERSION ENTERTAINMENT" +"TOTAL IMMERSION ENTERTAINMENT + +Developing a brain-net may also have an impact on the multibillion- +dollar entertainment industry. Back in the 1920s, the technology of tape¬ +recording sound as well as light was perfected. This set off a +transformation in the entertainment industry as it made the transition +from silent movies to the “talkies.” This basic formula of combining +sound and sight hasn’t changed much for the past century. But in the + + future, the entertainment industry may make the next transition, +recording all five senses, including smell, taste, and touch, as well as the +full range of emotions. Telepathic probes would be able to handle the +full range of senses and emotions that circulate in the brain, producing a +complete immersion of the audience in the story. Watching a romantic" +"movie or an action thriller, we would be swimming in an ocean of +sensations, as if we were really there, experiencing all the rush of +feelings and the emotions of the actors. We would smell the perfume of +the heroine, feel the terror of the victims in a horror movie, and relish +the vanquishing of the bad guys." +"This immersion would involve a radical shift in how movies are made. +First, actors would have to be trained to act out their roles with +EEG/MRI sensors and nanoprobes recording their sensations and +emotions. (This would place an added burden on the actors, who would +have to act out each scene by simulating all five senses. In the same way +that some actors could not make the transition from silent movies to the +talkies, perhaps a new generation of actors will emerge who can act out +scenes with all five senses.) Editing would require not just cutting and +splicing film, but also combining tapes of the various sensations within +each scene. And finally the audience, as they sit in their seats, would +have all these electrical signals fed into their brains. Instead of 3-D +glasses, the audience would wear brain sensors of some sort. Movie +theaters would also have to be retrofitted to process this data and then +send it to the people in the audience. + +CREATING A BRAIN-NET" +"CREATING A BRAIN-NET + +Creating a brain-net that can transmit such information would have to +be done in stages. The first step would be inserting nanoprobes into +important parts of the brain, such as the left temporal lobe, which +governs speech, and the occipital lobe, which governs vision. Then +computers would analyze these signals and decode them. This +information in turn could be sent over the Internet by fiber-optic cables. + +More difficult would be to insert these signals back into another +person’s brain, where they could be processed by the receiver. So far, +progress in this area has focused only on the hippocampus, but in the +future it should be possible to insert messages directly into other parts of +the brain corresponding to our sense of hearing, light, touch, etc. So +there is plenty of work to be done as scientists try to map the cortices of +the brain involved in these senses. Once these cortices have been +mapped—such as the hippocampus, which we’ll discuss in the next" +"chapter—it should be possible to insert words, thoughts, memories, and +experiences into another brain. + +Dr. Nicolelis writes, “It is not inconceivable that our human progeny +may indeed muster the skills, technology, and ethics needed to establish +a functional brain-net, a medium through which billions of human +beings consensually establish temporary direct contacts with fellow +human beings through thought alone. What such a colossus of collective +consciousness may look like, feel like, or do, neither I nor anyone in our +present time can possibly conceive or utter.” + +THE BRAIN-NET AND CIVILIZATION" +"A brain-net may even change the course of civilization itself. Each time a +new communication system has been introduced, it has irrevocably +accelerated changes in society, lifting us from one era to the next. In +prehistoric times, for thousands of years our ancestors were nomads +wandering in small tribes, communicating with one another through +body language and grunts. The coming of language allowed us for the +first time to communicate symbols and complex ideas, which facilitated +the rise of villages and eventually cities. Within the last few thousand +years, written language has enabled us to accumulate knowledge and +culture across generations, allowing for the rise of science, the arts, +architecture, and huge empires. The coming of the telephone, radio, and +TV extended the reach of communication across continents. The Internet +now makes possible the rise of a planetary civilization that will link all +the continents and peoples of the world. The next giant step might be a" +"the continents and peoples of the world. The next giant step might be a +planetary brain-net, in which the full spectrum of senses, emotions, +memories, and thoughts are exchanged on a global scale." +"‘WE WILL BE PART OF THEIR OPERATING SYSTEM' + +When I interviewed Dr. Nicolelis, he told me that he became interested +in science at an early age while growing up in his native Brazil. He +remembers watching the Apollo moon shot, which captured the world’s +attention. To him, it was an amazing feat. And now, he told me, his own +“moon shot” is making it possible to move any object with the mind. + +He became interested in the brain while still in high school, where he +came across a 1964 book by Isaac Asimov titled The Human Brain. But he +was disappointed by the end of the book. There was no discussion about +how all these structures interacted with one another to create the mind + + (because no one knew the answer back then). It was a life-changing +moment and he realized that his own destiny might lie in trying to +understand the secrets of the brain." +"About ten years ago, he told me, he began to look seriously into doing +research on his childhood dream. He started by taking a mouse and +letting it control a mechanical device. “We placed sensors into the mouse +which read the electrical signals from the brain. Then we transmitted +these signals to a little robotic lever that could bring water from a +fountain back to the mouse’s mouth. So the animal had to learn how to +mentally move the robotic device to bring the water back. That was the +first-ever demonstration that you could connect an animal to a machine +so that it could operate a machine without moving its own body,” he +explained to me." +"Today he can analyze not just fifty but one thousand neurons in the +brain of a monkey, which can reproduce various movements in different +parts of the monkey’s body. Then the monkey can control various +devices, such as mechanical arms, or even virtual images in cyberspace. +“We even have a monkey avatar that can be controlled by the monkey’s +thoughts without the monkey making any movement,” he told me. This +is done by having the monkey watch a video in which he sees an avatar +that represents his body. Then, by mentally commanding his body to +move, the monkey makes the avatar move in the corresponding way. + +Nicolelis envisions a day in the very near future when we will play +video games and control computers and appliances with our minds. “We + +will be part of their operating system. We will be immersed in them with +mechanisms that are very similar to the experiments that I am +describing.” + +EXOSKELETONS" +"EXOSKELETONS + +The next undertaking for Dr. Nicolelis is the Walk Again Project. Its goal +is nothing less than a complete exoskeleton for the body controlled by +the mind. At first, an exoskeleton conjures up an image of something +from the Iron Man movies. Actually, it is a special suit that encases the +entire body so that the arms and legs can move via motors. He calls it a +“wearable robot.” (See Figure 10.) + +His goal, he said, is to help the paralyzed “walk by thinking.” He plans +to use wireless technology, “so there’s nothing sticking out of the head. +... We are going to record twenty to thirty thousand neurons, to +command a whole body robotic vest, so he can think and walk again and + + move and grab objects.”" +"move and grab objects.” + +Nicolelis realizes that a series of hurdles must be overcome before the +exoskeleton becomes a reality. First, a new generation of microchips +must be created that can be placed in the brain safely and reliably for +years at a time. Second, wireless sensors must be created so the +exoskeleton can roam freely. The signals from the brain would be +received wirelessly by a computer the size of a cell phone that would +probably be attached to your belt. Third, new advances must be made in +deciphering and interpreting signals from the brain via computers. For +the monkeys, a few hundred neurons were necessary to control the +mechanical arms. For a human, you need, at minimum, several thousand +neurons to control an arm or leg. And fourth, a power supply must be +found that is portable and powerful enough to energize the entire +exoskeleton. + +Figure 10. This is the exoskeleton that Dr. Nicolelis hopes will be controlled by the mind of a totally +paralyzed person." +"(illustration credit 4.1) + +Nicolelis’s goal is a lofty one: to have a working exoskeleton suit ready +for the 2014 World Cup in Brazil, where a quadriplegic Brazilian will +deliver the opening kick. He told me proudly, “This is our Brazilian +moon shot.” + +AVATARS AND SURROGATES + +In the movie Surrogates, Bruce Willis plays an FBI agent who is +investigating mysterious murders. Scientists have created exoskeletons so +perfect that they exceed human capabilities. These mechanical creatures +are super strong, with perfect bodies. In fact, they are so perfect that +humanity has become dependent on them. People live their entire life in +pods, mentally controlling their handsome, beautiful surrogate with" +"wireless technology. Everywhere you go, you see busy “people” at work, +except they are all perfectly shaped surrogates. Their aging masters are +conveniently hidden from view. The plot takes a sharp twist, however, +when Bruce Willis discovers that the person behind these murders might +be linked to the same scientist who invented these surrogates in the first +place. That forces him to wonder whether the surrogates are a blessing +or a curse." +"And in the blockbuster movie Avatar, in the year 2154 Earth has +depleted most of its minerals, so a mining company has journeyed to a +distant moon called Pandora in the Alpha Centauri star system in search +of a rare metal, unobtanium. There are native people who inhabit this +distant moon, called the Na’vi, who live in harmony with their lush +environment. In order to communicate with the native people, specially +trained workers are placed in pods, where they learn to mentally control +the body of a genetically engineered native. Although the atmosphere is +poisonous and the environment differs radically from Earth’s, avatars +have no difficulty living in this alien world. This uneasy relationship, +however, soon collapses when the mining company finds a rich deposit +of unobtainium underneath the Na’vi’s sacred ceremonial tree. Inevitably +a conflict arises between the mining company, which wants to destroy +the sacred tree and strip-mine the land for its rare metal, and the" +"the sacred tree and strip-mine the land for its rare metal, and the +natives, who worship it. It looks like a lost cause for the natives until one +of the specially trained workers switches sides and leads the Na’vi to +victory." +"Avatars and surrogates are the stuff of science fiction today, but one +day they may become an essential tool for science. The human body is +frail, perhaps too delicate for the rigors of many dangerous missions, +including space travel. Although science fiction is filled with the heroic +exploits of brave astronauts traveling to the farthest reaches of our +galaxy, the reality is much different. Radiation in deep space is so +intense that our astronauts will have to be shielded or else face +premature aging, radiation sickness, and even cancer. Solar flares shot +from the sun can bathe a spacecraft in lethal radiation. A simple +transatlantic flight from the United States to Europe exposes you to a +millirem of radiation per hour, or roughly the same as a dental X-ray. +But in outer space, the radiation could be many times more intense, +especially in the presence of cosmic rays and solar bursts. (During" +"intense solar storms, NASA has actually warned astronauts in the space +station to move to sections where there is more shielding against +radiation.) + +In addition, there are many other dangers awaiting us in outer space, +such as micrometeorites, the effects of prolonged weightlessness, and the +problems of adjusting to different gravity fields. After just a few months +in weightlessness, the body loses a large fraction of its calcium and +minerals, leaving the astronauts incredibly weak, even if they exercise +every day. After a year in outer space, Russian astronauts had to crawl +out of their space capsules like worms. Furthermore, it is believed that +some of the effects of muscle and bone loss are permanent, so that +astronauts will feel the consequences of prolonged weightlessness for the +rest of their lives." +"The dangers of micrometeorites and intense radiation fields on the +moon are so great that many scientists have proposed using a gigantic +underground cave as a permanent lunar space station to protect our +astronauts. These caves form naturally as lava tubes near extinct +volcanoes. But the safest way of building a moon base is to have our +astronauts sit in the comfort of their living rooms. This way they would +be shielded from all the hazards found on the moon, yet through +surrogates they would be able to perform the same tasks. This could +vastly reduce the cost of manned space travel, since providing life +support for human astronauts is very expensive. + +Perhaps when the first interplanetary ship reaches a distant planet, +and an astronaut’s surrogate sets foot on this alien terrain, he or she +might start with “One small step for the mind ...”" +"One possible problem with this approach is that it takes time for +messages to go to the moon and beyond. In a little over a second, a radio +message can travel from Earth to the moon, so surrogates on the moon +could be easily controlled by astronauts on Earth. More difficult would +be communicating with surrogates on Mars, since it can take twenty +minutes or more for radio signals to reach the Red Planet. + +But surrogates have practical implications closer to home. In Japan, +the Fukushima reactor accident in 2011 caused billions of dollars in +damages. Because workers can’t enter areas with lethal levels of +radiation for more than a few minutes, the final cleanup may take up to +forty years. Unfortunately, robots are not sufficiently advanced to go" +"into these blistering radiation fields and make needed repairs. In fact, +the only robots used at Fukushima are quite primitive, basically simple +cameras placed on top of a computer sitting on wheels. A full-blown +automaton that can think for itself (or be controlled by a remote +operator) and make repairs in high-radiation fields is many decades +away." +"The lack of industrial robots caused an acute problem for the Soviets +as well during the 1986 Chernobyl accident in the Ukraine. Workers sent +directly to the accident site to put out the flames died horrible deaths +due to lethal exposure to radiation. Eventually Mikhail Gorbachev +ordered the air force to “sand bag” the reactor, dropping five thousand +tons of borated sand and cement by helicopter. Radiation levels were so +high that 250,000 workers were recruited to finally contain the accident. +Each worker could spend only a few minutes inside the reactor building +doing repairs. Many received the maximum lifetime allowed dose of +radiation. Each one got a medal. This massive project was the largest +civil engineering feat ever undertaken. It could not have been done by +today’s robots." +"The Honda Corporation has, in fact, built a robot that may eventually +go into deadly radioactive environments, but it is not ready yet. Honda’s +scientists have placed an EEG sensor on the head of a worker, which is +connected to a computer that analyzes his brain waves. The computer is +then connected to a radio that sends messages to the robot, called +ASIMO (Advanced Step in Innovative Mobility). Hence, by altering his +own brain waves, a worker can control ASIMO by pure thought. + +Unfortunately, this robot is incapable of making repairs at Fukushima +right now, since it can execute only four basic motions (all of which +involve moving its head and shoulders) while hundreds of motions are +required to make repairs at a shattered nuclear power plant. This system +is not developed enough to handle simple tasks such as turning a +screwdriver or swinging a hammer." +"Other groups have also explored the possibility of mentally controlled +robots. At the University of Washington, Dr. Rajesh Rao has created a +similar robot that is controlled by a person wearing an EEG helmet. This +shiny humanoid robot is two feet tall and is called Morpheus (after a +character in the movie The Matrix, as well as the Greek god of dreams). +A student puts on the EEG helmet and then makes certain gestures, such" +"as moving a hand, which creates an EEG signal that is recorded by a +computer. Eventually the computer has a library of such EEG signals, +each one corresponding to a specific motion of a limb. Then the robot is +programmed to move its hand whenever that EEG signal is sent to it. In +this way, if you think about moving your hand, the robot Morpheus +moves its hand as well. When you put on the EEG helmet for the first +time, it takes about ten minutes for the computer to calibrate to your +brain signals. Eventually you get the hang of making gestures with your +mind that control the robot. For example, you can have it walk toward +you, pick up a block from a table, walk six feet to another table, and +then place the block there." +"Research is also progressing rapidly in Europe. In 2012, scientists in +Switzerland at the Ecole Poly technique Federate de Lausanne unveiled +their latest achievement, a robot controlled telepathically by EEG sensors +whose controller is located sixty miles away. The robot itself looks like +the Roomba robotic vacuum cleaner now found in many living rooms. +But it is actually a highly sophisticated robot equipped with a camera +that can navigate its way through a crowded office. A paralyzed patient +can, for example, look at a computer screen, which is connected to a +video camera on the robot many miles away, and see through the eyes of +the robot. Then, by thinking, the patient is able to control the motion of +the robot as it moves past obstacles." +"In the future, one can imagine the most dangerous jobs being done by +robots controlled by humans in this fashion. Dr. Nicolelis says, “We will +likely be able to operate remotely controlled envoys and ambassadors, +robots and airships of many shapes and sizes, sent on our behalf to +explore other planets and stars in distant corners of the universe.” + +For example, in 2010 the world looked on in horror as 5 million +barrels of crude oil spilled unabated into the Gulf of Mexico. The +Deepwater Horizon spill was one of the largest oil disasters in history, +yet engineers were largely helpless for three months. Robotic subs, +which are controlled remotely, floundered for weeks trying to cap the +well because they lacked the dexterity and versatility necessary for this +underwater mission. If surrogate subs, which are much more sensitive in +manipulating tools, had been available, they might have capped the well +in the first few days of the spill, preventing billions in property damage +and lawsuits." +"Another possibility is that surrogate submarines might one day enter +the human body and perform delicate surgery from the inside. This idea +was explored in the movie Fantastic Voyage, starring Raquel Welch, in +which a submarine was shrunk down to the size of a blood cell and then +injected into the bloodstream of someone who had a blood clot in his +brain. Shrinking atoms violates the laws of quantum physics, but one +day MEMS (micro-electrical-mechanical systems) the size of cells might +be able to enter a person’s bloodstream. MEMS are incredibly small +machines that can easily fit on a pinpoint. MEMS employ the same +etching technology used in Silicon Valley, which can put hundreds of +millions of transistors on a wafer the size of your fingernail. An +elaborate machine with gears, levers, pulleys, and even motors can be +made smaller than the period at the end of this sentence. One day a +person may be able to put on a telepathy helmet and then command a" +"person may be able to put on a telepathy helmet and then command a +MEMS submarine using wireless technology to perform surgery inside a +patient." +"So MEMS technology may open up an entirely new field of medicine, +based on microscopic machines entering the body. These MEMS +submarines might even guide nanoprobes as they enter the brain so that +they connect precisely to the neurons that are of interest. In this way, +nanoprobes might be able to receive and transmit signals from the +handful of neurons that are involved in specific behaviors. The hit-or- +miss approach of inserting electrodes into the brain will be eliminated. + +THE FUTURE + +In the short term, all these remarkable advances taking place in + + laboratories around the world may alleviate the suffering of those +afflicted by paralysis and other disabilities. Using the power of their +minds, they will be able to communicate with loved ones, control their +wheelchairs and beds, walk by mentally guiding mechanical limbs, +manipulate household appliances, and lead seminormal lives." +"But in the long term, these advances could have profound economic +and practical implications for the world. By mid-century, it could +become commonplace to interact with computers directly with the mind. +Since the computer business is a multitrillion-dollar industry that can + +create young billionaires and corporations almost overnight, advances in +the mind-computer interface will reverberate on Wall Street—and also in +your living room. + +All the devices we use to communicate with computers (the mouse, +keyboards, etc.) may eventually disappear. In the future, we may simply +give mental commands and our wishes will be silently carried out by +tiny chips hidden in the environment. While sitting in our offices, taking +a stroll in the park, doing window-shopping, or just relaxing, our minds +could be interacting with scores of hidden chips, allowing us to mentally +balance our finances, arrange for theater tickets, or make a reservation." +"Artists may also make good use of this technology. If they can +visualize their artwork in their minds, then the image can be displayed +via EEG sensors on a holographic screen in 3-D. Since the image in the +mind is not as precise as the original object, the artist could then make +improvements on the 3-D image and dream up the next iteration. After +several cycles, the artist could print out the final image on a 3-D printer. + +Similarly, engineers would be able to create scale models of bridges, +tunnels, and airports by simply using their imagination. They could also +rapidly make changes in their blueprints through thought alone. +Machine parts could fly off the computer screen and into a 3-D printer." +"Some critics, however, have claimed that these telekinetic powers +have one great limitation: the lack of energy. In the movies, super beings +have the power to move mountains using their thoughts. In the movie X- +Men: The Last Stand, the super villain Magneto had the ability to move +the Golden Gate Bridge simply by pointing his fingers, but the human +body can muster only about one-fifth of a horsepower on average, which +is much too little power to perform the feats we see in the comic books. +Therefore, all the herculean feats of telekinetic super beings appear to be +pure fantasy. + +There is one solution to this energy problem, however. You may be +able to connect your thoughts to a power source, which would then" +"magnify your power millions of times. In this way, you could +approximate the power of a god. In one episode of Star Trek, the crew +journeys to a distant planet and meets a godlike creature who claims to +be Apollo, the Greek god of the sun. He can perform feats of magic that +dazzle the crew. He even claims to have visited Earth eons ago, where +the earthlings worshipped him. But the crew, not believing in gods, + +suspect a fraud. Later they figure out that this “god” just mentally +controls a hidden power source, which then performs all the magic +tricks. When this power source is destroyed, he becomes a mere mortal." +"Similarly, in the future our minds may mentally control a power +source that will then give us superpowers. For example, a construction +worker might telepathically exploit a power source that energizes heavy +machinery. Then a single worker might be able to build complex +buildings and houses just by using the power of his mind. All the heavy +lifting would be done by the power source, and the construction worker +would resemble a conductor, able to orchestrate the motion of colossal +cranes and powerful bulldozers through thought alone. + +Science is beginning to catch up to science fiction in yet another way. +The Star Wars saga was supposed to take place in a time when +civilizations span the entire galaxy. The peace of the galaxy, in turn, is +maintained by the Jedi Knights, a highly trained cadre of warriors who +use the power of the “Force” to read minds and guide their lightsabers." +"However, one need not wait until we have colonized the entire galaxy +to begin contemplating the Force. As we’ve seen, some aspects of the +Force are possible today, such as being able to tap into the thoughts of +others using ECOG electrodes or EEG helmets. But the telekinetic powers +of the Jedi Knights will also become a possibility as we learn to harness +a power source with our minds. The Jedi Knights, for example, can +summon a light-saber simply by waving their hands, but we can already +accomplish the same feat by exploiting the power of magnetism (much +as the magnet in an MRI machine can hurl a hammer across a room). By +mentally activating the power source, you can grab lightsabers from +across the room with today’s technology. + +THE POWER OF A GOD" +"THE POWER OF A GOD + +Telekinesis is a power usually reserved for a deity or a superhero. In the +universe of superheros appearing in blockbuster Hollywood movies, +perhaps the most powerful character is Phoenix, a telekinetic woman +who can move any object at will. As a member of the X-Men, she can lift +heavy machinery, hold back floods, or raise jet airplanes via the power + + of her mind. (However, when she is finally consumed by the dark side of + +her power, she goes on a cosmic rampage, capable of incinerating entire +solar systems and destroying stars. Her power is so great and +uncontrollable that it leads to her eventual self-destruction.) + +But how far can science go in harnessing telekinetic powers?" +"But how far can science go in harnessing telekinetic powers? + +In the future, even with an external power source to magnify our +thoughts, it is unlikely that people with telekinetic powers will be able +to move basic objects like a pencil or mug of coffee on command. As we +mentioned, there are only four known forces that rule the universe, and +none of them can move objects unless there is an external power source. +(Magnetism comes close, but magnetism can move only magnetic +objects. Objects made of plastic, water, or wood can easily pass through +magnetic fields.) Simple levitation, a trick found in most magicians’ +shows, is beyond our scientific capability. + +So even with an external power supply, is it unlikely that a telekinetic +person would be able to move the objects around them at will. However, +there is a technology that may come close, and that involves the ability +to change one object into another." +"The technology is called “programmable matter,” and it has become a +subject of intense research for the Intel Corporation. The idea behind +programmable matter is to create objects made of tiny “catoms,” which +are microscopic computer chips. Each catom can be controlled +wirelessly; it can be programmed to change the electrical charge on its +surface so it can bind with other catoms in different ways. By +programming the electric charges one way, the catoms bind together to +form, say, a cell phone. Push a button to change their programming, and +the catoms rearrange themselves to re-form into another object, like a +laptop." +"I saw a demonstration of this technology at Carnegie Mellon +University in Pittsburgh, where scientists have been able to create a chip +the size of a pinpoint. To exam these catoms, I had to enter a “clean +room” wearing a special white uniform, plastic boots, and a cap to +prevent even the smallest dust particle from entering. Then, under a +microscope, I could see the intricate circuitry inside each catom, which +makes it possible to program it wirelessly to change the electrical charge +on its surface. In the same way we can program software today, in the +future it may be possible to program hardware. + +The next step is to determine if these catoms can combine to form" +"The next step is to determine if these catoms can combine to form + + useful objects, and to see if they can be changed or morphed into +another object at will. It may take until mid-century before we have +working prototypes of programmable matter. Because of the complexity +of programming billions of catoms, a special computer would have to be +created to orchestrate the charge on each catom. Perhaps by the end of +this century, it will be possible to mentally control this computer so that +we can change one object into another. We would not have to memorize +the charges and configuration within an object. We would just give the +mental command to the computer to change one object into another." +"Eventually we might have catalogs listing all the various objects that +are programmable, such as furniture, appliances, and electronics. Then +by telepathically communicating with the computer, it should be +possible to change one object into another. Redecorating your living +room, remodeling your kitchen, and buying Christmas presents could all +be done mentally. + +A MORALITY TALE + +Having every wish come true is something that only a divinity can +accomplish. However, there is also a downside to this celestial power. +All technologies can be used for good or for evil. Ultimately, science is a +double-edged sword. One side of the sword can cut against poverty, +disease, and ignorance. But the other side can cut against people, in +several ways." +"These technologies could conceivably make wars even more vicious. +Perhaps one day, all hand-to-hand combat will be between two +surrogates, armed with a battery of high-tech weapons. The actual +warriors, sitting safely thousands of miles away, would unleash a +barrage of the latest high-tech weaponry with little regard for the +collateral damage they are inflicting on civilians. Although wars fought +with surrogates may preserve the lives of the soldiers themselves, they +might also cause horrendous civilian and property damage. + +The bigger problem is that this power may also be too great for any +common mortal to control. In the novel Carrie, Stephen King explored +the world of a young girl who was constantly taunted by her peers. She +was ostracized by the in-crowd and her life became a never-ending series + +of insults and humiliations. However, her tormentors did not know one +thing about her: she was telekinetic. + +After enduring the taunts and having blood splashed all over her dress" +"After enduring the taunts and having blood splashed all over her dress + + at the prom, she finally cracks. She summons all her telekinetic power to +trap her classmates and then annihilate them one by one. In a final +gesture, she decides to burn the entire school down. But her telekinetic +power was too great to control. She ultimately perishes in the fire that +she started. + +Not only can the awesome power of telekinesis backfire, but there is +another problem as well. Even if you have taken all the precautions to +understand and harness this power, it could still destroy you if, +ironically enough, it is too obedient to your thoughts and commands. +Then the very thoughts you conceive may spell your doom." +"The movie Forbidden Planet (1956) is based on a play by William +Shakespeare, The Tempest, which begins with a sorcerer and his daughter +stranded on a deserted island. But in Forbidden Planet, a professor and his +daughter are stranded on a distant planet that was once the home of the +Krell, a civilization millions of years more advanced than ours. Their +greatest achievement was to create a device that gave them the ultimate +power of telekinesis, the power to control matter in all its forms by the +mind. Anything they desired suddenly materialized before them. This +was the power to reshape reality itself to their whims. + +Yet on the eve of their greatest triumph, as they were turning on this +device the Krell disappeared without a trace. What could have possibly +destroyed this most advanced civilization?" +"When a crew of earthmen land on the planet to rescue the man and +his daughter, they find that there is a hideous monster haunting the +planet, slaughtering crew members at will. Finally, one crew member +discovers the secret behind both the Krell and the monster. Before he +dies, he gasps, “Monsters from the id.” + +Then the shocking truth suddenly dawns on the professor. The very +night that the Krell turned on their telekinesis machine, they fell asleep. +All the repressed desires from their ids then suddenly materialized. +Buried in the subconscious of these highly developed creatures were the +long-suppressed animal urges and desires of their ancient past. Every +fantasy, every dream of revenge suddenly came true, so this great +civilization destroyed itself overnight. They had conquered many worlds, + +but there was one thing they could not control: their own subconscious +minds." +"but there was one thing they could not control: their own subconscious +minds. + +That is a lesson for anyone who desires to unleash the power of the +mind. Within the mind, you find the noblest achievements and thoughts +of humanity. But you will also find monsters from the id. + + CHANGING WHO WE ARE: OUR MEMORIES AND INTELLIGENCE + +So far, we have discussed the power of science to extend our mental +abilities via telepathy and telekinesis. We basically remain the same; +these developments do nothing to change the essence of who we are. +However, there is an entirely new frontier opening up that alters the +very nature of what it means to be human. Using the very latest in +genetics, electromagnetics, and drug therapy, it may become possible in +the near future to alter our memories and even enhance our intelligence. +The idea of downloading a memory, learning complex skills overnight, +and becoming super intelligent is slowly leaving the realm of science +fiction." +"Without our memories, we are lost, cast adrift in an aimless sea of +pointless stimuli, unable to understand the past or ourselves. So what +happens if one day we can input artificial memories into our brains? +What happens when we can become a master of any discipline simply by +downloading the file into our memory? And what happens if we cannot +tell the difference between real and fake memories? Then who are we? + +Scientists are moving past being passive observers of nature to actively +shaping and molding nature. This means that we might be able to +manipulate memories, thoughts, intelligence, and consciousness. Instead +of simply witnessing the intricate mechanics of the mind, in the future it +will be possible to orchestrate them. + +So let us now answer this question: Can we download memories? + +If our brains were simple enough to be understood, we +wouldn’t be smart enough to understand them. + +—ANONYMOUS + +5 MEMORIES AND THOUGHTS MADE TO ORDER" +"—ANONYMOUS + +5 MEMORIES AND THOUGHTS MADE TO ORDER + +Neo is The One. Only he can lead a defeated humanity to victory +against the Machines. Only Neo can destroy the Matrix, which has +implanted false memories into our brains as a means to control us. + +In a now-classic scene from the film The Matrix, the evil Sentinels, +who guard the Matrix, have finally cornered Neo. It looks like +humanity’s last hope is about to be terminated. But previously Neo had + + had an electrode jacked into the back of his neck that could instantly +download martial-arts skills into his brain. In seconds, he becomes a +karate master able to take down the Sentinels with breathtaking aerial +kicks and well-placed strikes. + +In The Matrix, learning the amazing skills of a black-belt karate master +is no harder than slipping an electrode into your brain and pushing the +“download” button. Perhaps one day we, too, may be able to download +memories, which will vastly increase our abilities." +"But what happens when the memories downloaded into your brain are +false? In the movie Total Recall, Arnold Schwarzenegger has fake +memories placed into his brain, so that the distinction between reality +and fiction becomes totally blurred. He valiantly fights off the bad guys +on Mars until the end of the movie, when he suddenly realizes that he +himself is their leader. He is shocked to find that his memories of being a +normal, law-abiding citizen are totally manufactured. + +Hollywood is fond of movies that explore the fascinating but fictional +world of artificial memories. All this is impossible, of course, with +today’s technology, but one can envision a day, a few decades from now, +when artificial memories may indeed be inserted into the brain. + +HOW WE REMEMBER + +Like Phineas Gage’s, the strange case of Henry Gustav Molaison, known +in the scientific literature as simply HM, created a sensation in the field" +"of neurology that led to many fundamental breakthroughs in +understanding the importance of the hippocampus in formulating +memories." +"At the age of nine, HM suffered head injuries in an accident that +caused debilitating convulsions. In 1953, when he was twenty-five years +old, he underwent an operation that successfully relieved his symptoms. +But another problem surfaced because surgeons mistakenly cut out part +of his hippocampus. At first, HM appeared normal, but it soon became +apparent that something was terribly wrong; he could not retain new +memories. Instead, he constantly lived in the present, greeting the same +people several times a day with the same expressions, as if he were +seeing them for the first time. Everything that went into his memory +lasted only a few minutes before it disappeared. Like Bill Murray in the +movie Groundhog Day, HM was doomed to relive the same day, over and +over, for the rest of his life. But unlike Bill Murray’s character, he was +unable to recall the previous iterations. His long-term memory, however," +"was relatively intact and could remember his life before the surgery. But +without a functioning hippocampus, HM was unable to record new +experiences. For example, he would be horrified when looking in a +mirror, since he saw the face of an old man but thought he was still +twenty-five. But mercifully, the memory of being horrified would also +soon disappear into the fog. In some sense, HM was like an animal with +Level II consciousness, unable to recall the immediate past or simulate +the future. Without a functioning hippocampus, he regressed from Level +III down to Level II consciousness. + +Today, further advances in neuroscience have given us the clearest +picture yet of how memories are formed, stored, and then recalled. “It +has all come together just in the past few years, due to two technical +developments—computers and modern brain scanning,” says Dr. +Stephen Kosslyn, a neuroscientist at Harvard." +"As we know, sensory information (e.g., vision, touch, taste) must first +pass through the brain stem and onto the thalamus, which acts like a +relay station, directing the signals to the various sensory lobes of the +brain, where they are evaluated. The processed information reaches the +prefrontal cortex, where it enters our consciousness and forms what we +consider our short-term memory, which can range from several seconds +to minutes. (See Figure 11.)" +"To store these memories for a longer duration, the information must +then run through the hippocampus, where memories are broken down +into different categories. Rather than storing all memories in one area of +the brain like a tape recorder or hard drive, the hippocampus redirects +the fragments to various cortices. (Storing memories in this way is +actually more efficient than storing them sequentially. If human +memories were stored sequentially, like on computer tape, a vast +amount of memory storage would br required. In fact, in the future, even +digital storage systems may adopt this trick from the living brain, rather +than storing whole memories sequentially.) For instance, emotional +memories are stored in the amygdala, but words are recorded in the +temporal lobe. Meanwhile, colors and other visual information are +collected in the occipital lobe, and the sense of touch and movement +reside in the parietal lobe. So far, scientists have identified more than" +"reside in the parietal lobe. So far, scientists have identified more than +twenty categories of memories that are stored in different parts of the +brain, including fruits and vegetables, plants, animals, body parts, +colors, numbers, letters, nouns, verbs, proper names, faces, facial +expressions, and various emotions and sounds." +"Figure 11. This shows the path taken to create memories. Impulses from the senses pass through the +brain stem, to the + + thalamus, out to the various cortices, and then to the prefrontal cortex. They then pass to the +hippocampus to form long¬ +term memories, (illustration credit 5.1) + +A single memory—for instance, a walk in the park—involves +information that is broken down and stored in various regions of the +brain, but reliving just one aspect of the memory (e.g., the smell of +freshly cut grass) can suddenly send the brain racing to pull the +fragments together to form a cohesive recollection. The ultimate goal of +memory research is, then, to figure out how these scattered fragments +are somehow reassembled when we recall an experience. This is called +the “binding problem,” and a solution could potentially explain many +puzzling aspects of memory. For instance, Dr. Antonio Damasio has +analyzed stroke patients who are incapable of identifying a single" +"category, even though they are able to recall everything else. This is +because the stroke has affected just one particular area of the brain, +where that certain category was stored. + +The binding problem is further complicated because all our memories +and experiences are highly personal. Memories might be customized for +the individual, so that the categories of memories for one person may +not correlate with the categories of memories for another. Wine tasters, +for example, may have many categories for labeling subtle variations in +taste, while physicists may have other categories for certain equations. +Categories, after all, are by-products of experience, and different people +may therefore have different categories." +"One novel solution to the binding problem uses the fact that there are +electromagnetic vibrations oscillating across the entire brain at roughly +forty cycles per second, which can be picked up by EEG scans. One +fragment of memory might vibrate at a very precise frequency and +stimulate another fragment of memory stored in a distant part of the +brain. Previously it was thought that memories might be stored +physically close to one another, but this new theory says that memories +are not linked spatially but rather temporally, by vibrating in unison. If +this theory holds up, it means that there are electromagnetic vibrations +constantly flowing through the entire brain, linking up different regions +and thereby re-creating entire memories. Hence the constant flow of +information between the hippocampus, the prefrontal cortex, the +thalamus, and the different cortices might not be entirely neural after +all. Some of this flow may be in the form of resonance across different +brain structures." +"RECORDING A MEMORY + + Sadly, HM died in 2008 at the age of eighty-two, before he could take +advantage of some sensational results achieved by science: the ability to +create an artificial hippocampus and then insert memories into the brain. +This is something straight out of science fiction, but scientists at Wake +Forest University and the University of Southern California made history +in 2011 when they were able to record a memory made by mice and +store it digitally in a computer. This was a proof-of-principle experiment, + +in which they showed that the dream of downloading memories into the +brain might one day become reality." +"At first, the very idea of downloading memories into the brain seems +like an impossible dream, because, as we have seen, memories are +created by processing a variety of sensory experiences, which are then +stored in multiple places in the neocortex and limbic system. But as we +know from HM, there is one place through which all memories flow and +are converted into long-term memories: the hippocampus. Team leader +Dr. Theodore Berger of USC says, “If you can’t do it with the +hippocampus, you can’t do it anywhere.”" +"The scientists at Wake Forest and USC first started with the +observation, garnered from brain scans, that there are at least two sets of +neurons in a mouse’s hippocampus, called CA1 and CA3, which +communicate with each other as a new task is learned. After training +mice to press two bars, one after the other, in order to get water, the +scientists reviewed the findings and attempted to decode these messages, +which proved frustrating at first since the signals between these two sets +of neurons didn’t appear to follow a pattern. But by monitoring the +signals millions of times, they were eventually able to determine which +electrical input created which output. With the use of probes in the +mice’s hippocampi, the scientists were able to record the signals between +CA1 and CA3 when the mice learned to press the two bars in sequence." +"Then the scientists injected the mice with a special chemical, making +them forget the task. Finally they played back the memory into the same +mouse’s brain. Remarkably, the memory of the task returned, and the +mice could successfully reproduce the original task. Essentially, they had +created an artificial hippocampus with the ability to duplicate digital +memory. “Turn the switch on, the animal has the memory; turn it off +and they don’t,” says Dr. Berger. “It’s a very important step because it’s +the first time we have put all the pieces together.” + +As Joel Davis of the Office of the Chief of Naval Operations, which +sponsored this work, said, “Using implantables to enhance competency is +down the road. It’s only a matter of time.”" +"Not surprisingly, with so much at stake, this area of research is +moving very rapidly. In 2013, yet another breakthrough was made, this +time at MIT, by scientists who were able to implant not just ordinary +memories into a mouse, but false ones as well. This means that, one day, + +memories of events that never took place may be implanted into the +brain, which would have a profound impact on fields like education and +entertainment. + +The MIT scientists used a technique called optogenetics (which we will +discuss more in Chapter 8), which allows you to shine a light on specific +neurons to activate them. Using this powerful method, scientists can +identify the specific neurons responsible for certain memories." +"Let’s say that a mouse enters a room and is given a shock. The neurons +responsible for the memory of that painful event can actually be isolated +and recorded by analyzing the hippocampus. Then the mouse is placed +in an entirely different room that is totally harmless. By turning on a +light on an optical fiber, one can use optogenetics to activate the +memory of the shock, and the mouse exhibits a fear response, although +the second room is totally safe. + +In this way, the MIT scientists were able not only to implant ordinary +memories, but also memories of events that never took place. One day, +this technique may give educators the ability to implant memories of +new skills to retrain workers, or give Hollywood an entirely new form of +entertainment. + +AN ARTIFICIAL HIPPOCAMPUS" +"AN ARTIFICIAL HIPPOCAMPUS + +At present, the artificial hippocampus is primitive, able to record only a +single memory at a time. But these scientists plan to increase the +complexity of their artificial hippocampus so that it can store a variety +of memories and record them for different animals, eventually working +up to monkeys. They also plan to make this technology wireless by +replacing the wires with tiny radios so that memories can be +downloaded remotely without the need for clumsy electrodes implanted +into the brain. + +Because the hippocampus is involved with memory processing in +humans, scientists see a vast potential application in treating strokes, +dementia, Alzheimer’s, and a host of other problems that occur when +there is damage or deterioration in this region of the brain. + + Many hurdles have to be negotiated, of course. Despite all we have +learned about the hippocampus since HM, it still remains something of a" +"black box whose inner workings are largely unknown. As a result, it is +not possible to construct a memory from scratch, but once a task has +been performed and the memory processed, it is possible to record it and +play it back. + +FUTURE DIRECTIONS + +Working with the hippocampus of primates and even humans will be +more difficult, since their hippocampi are much larger and more +complex. The first step is to create a detailed neural map of the +hippocampus. This means placing electrodes at different parts of the +hippocampus to record the signals that are constantly being exchanged +between different regions. This will establish the flow of information +that constantly moves across the hippocampus. The hippocampus has +four basic divisions, CA1 to CA4, and hence scientists will record the +signals that are exchanged between them." +"The second step involves the subject performing certain tasks, after +which scientists will record the impulses that flow across the various +regions of the hippocampus, thereby recording the memory. For +example, the memory of learning a certain task, such as jumping +through a hoop, will create electrical activity in the hippocampus that +can be recorded and carefully analyzed. Then a dictionary can be +created matching the memory with the flow of information across the +hippocampus. + +Finally, step three involves making a recording of this memory and +feeding the electrical signal into the hippocampus of another subject via +electrodes, to see if that memory can been uploaded. In this fashion, the +subject may learn to jump through a hoop although it has never done so +before. If successful, scientists would gradually create a library +containing recordings of certain memories." +"It may take decades to work all the way up to human memories, but +one can envision how it might work. In the future, people may be hired +to create certain memories, like a luxury vacation or a fictitious battle. +Nanoelectrodes will be placed at various places in their brain to record +the memory. These electrodes must be extremely small so that they do +not interfere with the formation of the memory. + +The information from these electrodes will then be sent wirelessly to a + + computer and then recorded. Later a subject who wants to experience +these memories will have similar electrodes placed in his hippocampus, +and the memory will be inserted into the brain." +"(There are complications to this idea, of course. If we try to insert the +memory of physical activity, such as a martial art, we have the problem +of “muscle memory.” For example, when walking, we do not consciously +think about putting one leg in front of the other. Walking has become +second nature to us because we do it so often, and from an early age. +This means that the signals controlling our legs no longer originate +entirely in the hippocampus, but also in the motor cortex, the +cerebellum, and the basal ganglia. In the future, if we wish to insert +memories involving sports, scientists may have to decipher the way in +which memories are partially stored in other areas of the brain as well.) + +VISION AND HUMAN MEMORIES" +"VISION AND HUMAN MEMORIES + +The formation of memories is quite complex, but the approach we have +been discussing takes a shortcut by eavesdropping on the signals moving +through the hippocampus, where the sensory impulses have already +been processed. In The Matrix, however, an electrode is placed in the +back of the head to upload memories directly into the brain. This +assumes that one can decode the raw, unprocessed impulses coming in +from the eyes, ears, skin, etc., that are moving up the spinal cord and +brain stem and into the thalamus. This is much more elaborate and +difficult than analyzing the processed messages circulating in the +hippocampus." +"To give you a sense of the sheer volume of unprocessed information +that comes up the spinal cord into the thalamus, let’s consider just one +aspect: vision, since many of our memories are encoded this way. There +are roughly 130 million cells in the eye’s retina, called cones and rods; +they process and record 100 million bits of information from the +landscape at any time. + +This vast amount of data is then collected and sent down the optic +nerve, which transports 9 million bits of information per second, and on +to the thalamus. From there, the information reaches the occipital lobe, + +at the very back of the brain. This visual cortex, in turn, begins the +arduous process of analyzing this mountain of data. The visual cortex +consists of several patches at the back of the brain, each of which is +designed for a specific task. They are labeled VI to V8. + +Remarkably, the area called VI is like a screen; it actually creates a" +"Remarkably, the area called VI is like a screen; it actually creates a + + pattern on the back of your brain very similar in shape and form to the +original image. This image bears a striking resemblance to the original, +except that the very center of your eye, the fovea, occupies a much +larger area in VI (since the fovea has the highest concentration of +neurons). The image cast on VI is therefore not a perfect replica of the +landscape but is distorted, with the central region of the image taking up +most of the space. + +Besides VI, other areas of the occipital lobe process different aspects +of the image, including: + +• Stereo vision. These neurons compare the images coming in from +each eye. This is done in area V2. + +• Distance. These neurons calculate the distance to an object, using +shadows and other information from both eyes. This is done in area +V3. + +• Colors are processed in area V4." +"• Colors are processed in area V4. + +• Motion. Different circuits can pick out different classes of motion, +including straight-line, spiral, and expanding motion. This is done in +area V5. + +More than thirty different neural circuits involved with vision have +been identified, but there are probably many more. + +From the occipital lobe, the information is sent to the prefrontal +cortex, where you finally “see” the image and form your short-term +memory. The information is then sent to the hippocampus, which +processes it and stores it for up to twenty-four hours. The memory is +then chopped up and scattered among the various cortices. + +The point here is that vision, which we think happens effortlessly, +requires billions of neurons firing in sequence, transmitting millions of +bits of information per second. And remember that we have signals from +five sense organs, plus emotions associated with each image. All this" +"information is processed by the hippocampus to create a simple memory +of an image. At present, no machine can match the sophistication of this +process, so replicating it presents an enormous challenge for scientists +who want to create an artificial hippocampus for the human brain. + +REMEMBERING THE FUTURE + + If encoding the memory of just one of the senses is such a complex +process, then how did we evolve the ability to store such vast amounts of +information in our long-term memory? Instinct, for the most part, guides +the behavior of animals, which do not appear to have much of a long¬ +term memory. But as neurobiologist Dr. James McGaugh of the +University of California at Irvine says, “The purpose of memory is to +predict the future,” which raises an interesting possibility. Perhaps long¬ +term memory evolved because it was useful for simulating the future. In +other words, the fact that we can remember back into the distant past is +due to the demands and advantages of simulating the future." +"Indeed, brain scans done by scientists at Washington University in St. +Louis indicate that areas used to recall memories are the same as those +involved in simulating the future. In particular, the link between the +dorsolateral prefrontal cortex and the hippocampus lights up when a +person is engaged in planning for the future and remembering the past. +In some sense, the brain is trying to “recall the future,” drawing upon +memories of the past in order to determine how something will evolve +into the future. This may also explain the curious fact that people who +suffer from amnesia—such as HM—are often unable to visualize what +they will be doing in the future or even the very next day." +"“You might look at it as mental time travel—the ability to take +thoughts about ourselves and project them either into the past or into +the future,” says Dr. Kathleen McDermott of Washington University. She +also notes that their study proves a “tentative answer to a longstanding +question regarding the evolutionary usefulness of memory. It may just be +that the reason we can recollect the past in vivid detail is that this set of +processes is important for being able to envision ourselves in future +scenarios. This ability to envision the future has clear and compelling +adaptive significance.” For an animal, the past is largely a waste of + +precious resources, since it gives them little evolutionary advantage. But +simulating the future, given the lessons of the past, is an essential reason +why humans became intelligent. + +AN ARTIFICIAL CORTEX" +"AN ARTIFICIAL CORTEX + +In 2012 the same scientists from Wake Forest Baptist Medical Center and +the University of Southern California who created an artificial +hippocampus in mice announced an even more far-reaching experiment. +Instead of recording a memory in the mouse hippocampus, they +duplicated the much more sophisticated thinking process of the cortex of +a primate." +"They took five rhesus monkeys and inserted tiny electrodes into two +layers of their cortex, called the L2/3 and L5 layers. They then recorded +neural signals that went between these two layers as the monkeys +learned a task. (This task involved the monkeys seeing a set of pictures, +and then being rewarded if they could pick out these same pictures from +a much larger set.) With practice, the monkeys could perform the task +with 75 percent accuracy. But if the scientists fed the signal back into +the cortex as the monkey was performing the test, its performance +increased by 10 percent. When certain chemicals were given to the +monkey, its performance dropped by 20 percent. But if the recording +was fed back into the cortex, its performance exceeded its normal level. +Although this was a small sample size and there was only a modest +improvement in performance, the study still suggests that the scientists’ +recording accurately captured the decision-making process of the cortex." +"Because this study was done on primates rather than mice and +involved the cortex and not the hippocampus, it could have vast +implications when human trials begin. Dr. Sam A. Deadwyler of Wake +Forest says, “The whole idea is that the device would generate an output +pattern that bypasses the damaged area, proving an alternative +connection” in the brain. This experiment has a possible application for +patients whose neocortex has been damaged. Like a crutch, this device +would perform the thinking operation of the damaged area. + +AN ARTIFICIAL CEREBELLUM + +It should also be pointed out that the artificial hippocampus and +neocortex are but the first steps. Eventually, other parts of the brain will +have artificial counterparts. For example, scientists at Tel Aviv +University in Israel have already created an artificial cerebellum for a +rat. The cerebellum is an essential part of the reptilian brain that +controls our balance and other basic bodily functions." +"Usually when a puff of air is directed at a rat’s face, it blinks. If a +sound is made at the same time, the rat can be conditioned to blink just +by hearing the sound. The goal of the Israeli scientists was to create an +artificial cerebellum that could duplicate this feat. + +First the scientists recorded the signals entering the brain stem when +the puff of air hit the rat’s face and the sound was heard. Then the signal +was processed and sent back to the brain stem at another location. As +expected, the rats blinked upon receiving the signal. Not only is this the +first time that an artificial cerebellum functioned correctly, it is the first +time that messages were received from one part of the brain, processed, +and then uploaded into a different part of the brain." +"Commenting on this work, Francesco Sepulveda of the University of +Essex says, “This demonstrates how far we have come towards creating +circuitry that could one day replace damaged brain areas and even +enhance the power of the healthy brain.” + +He also sees great potential for artificial brains in the future, adding, +“It will likely take us several decades to get there, but my bet is that +specific, well-organized brain parts such as the hippocampus or the +visual cortex will have synthetic correlates before the end of the +century.” + +Although progress in creating artificial replacements for the brain is +moving remarkably fast given the complexity of the process, it is a race +against time when one considers the greatest threat facing our public +health system, the declining mental abilities of people with Alzheimer’s. + +ALZHEIMER’S—DESTROYER OF MEMORY" +"ALZHEIMER’S—DESTROYER OF MEMORY + +Alzheimer’s disease, some people claim, might be the disease of the +century. There are 5.3 million Americans who currently have +Alzheimer’s, and the number is expected to quadruple by 2050. Five + +percent of people from age sixty-five to seventy-four have Alzheimer’s, +but more than 50 percent of those over eighty-five have it, even if they +have no obvious risk factors. (Back in 1900, life expectancy in the +United States was forty-nine, so Alzheimer’s was not a significant +problem. But now, people over eighty are one of the fastest-growing +demographic groups in the country.)" +"In the early stages of Alzheimer’s, the hippocampus, the part of the +brain through which memories are processed, begins to deteriorate. +Indeed, brain scans clearly show that the hippocampus shrinks in +Alzheimer’s patients, but the wiring linking the prefrontal cortex to the +hippocampus also thins, leaving the brain unable to properly process +short-term memories. Long-term memories already stored throughout +the cortices of the brain remain relatively intact, at least at first. This +creates a situation where you may not remember what you just did a few +minutes ago but can clearly recall events that took place decades ago. + +Eventually, the disease progresses to the point where even basic long¬ +term memories are destroyed. The person is unable to recognize their +children or spouse and to remember who they are, and can even fall into +a comalike vegetative state. + +Sadly, the basic mechanisms for Alzheimer’s have only recently begun" +"Sadly, the basic mechanisms for Alzheimer’s have only recently begun + + to be understood. One major breakthrough came in 2012, when it was +revealed that Alzheimer’s begins with the formation of tau amyloid +proteins, which in turn accelerates the formation of beta amyloid, a +gummy, gluelike substance that clogs up the brain. (Before, it was not +clear if Alzheimer’s was caused by these plaques or whether perhaps +these plaques were by-products of a more fundamental disorder.)" +"What makes these amyloid plaques so difficult to target with drugs is +that they are most likely made of “prions,” which are misshapen protein +molecules. They are not bacteria or viruses, but nevertheless they can +reproduce. When viewed atomically, a protein molecule resembles a +jungle of ribbons of atoms tied together. This tangle of atoms must fold +onto itself correctly for the protein to assume the proper shape and +function. But prions are misshapen proteins that have folded incorrectly. +Worse, when they bump into healthy proteins, they cause them to fold +incorrectly as well. Hence one prion can cause a cascade of misshapen +proteins, creating a chain reaction that contaminates billions more. + +At present, there is no known way to stop the inexorable progression" +"At present, there is no known way to stop the inexorable progression + +of Alzheimer’s. Now that the basic mechanics behind Alzheimer’s are +being unraveled, however, one promising method is to create antibodies +or a vaccine that might specifically target these misshapen protein +molecules. Another way might be to create an artificial hippocampus for +these individuals so that their short-term memory can be restored. + +Yet another approach is to see if we can directly increase the brain’s +ability to create memories using genetics. Perhaps there are genes that +can improve our memory. The future of memory research may lie in the +“smart mouse.” + +THE SMART MOUSE" +"THE SMART MOUSE + +In 1999, Dr. Joseph Tsien and colleagues at Princeton, MIT, and +Washington University found that adding a single extra gene +dramatically boosted a mouse’s memory and ability. These “smart mice” +could navigate mazes faster, remember events better, and outperform +other mice in a wide variety of tests. They were dubbed “Doogie mice,” +after the precocious character on the TV show Doogie Howser, M.D. + +Dr. Tsien began by analyzing the gene NR2B, which acts like a switch +controlling the brain’s ability to associate one event with another. +(Scientists know this because when the gene is silenced or rendered +inactive, mice lose this ability.) All learning depends on NR2B, because +it controls the communication between memory cells of the" +"hippocampus. First Dr. Tsien created a strain of mice that lacked NR2B, +and they showed impaired memory and learning disabilities. Then he +created a strain of mice that had more copies of NR2B than normal, and +found that the new mice had superior mental capabilities. Placed in a +shallow pan of water and forced to swim, normal mice would swim +randomly about. They had forgotten from just a few days before that +there was a hidden underwater platform. The smart mice, however, went +straight to the hidden platform on the first try. + +Since then, researchers have been able to confirm these results in +other labs and create even smarter strains of mice. In 2009, Dr. Tsien +published a paper announcing yet another strain of smart mice, dubbed +“Hobbie-J” (named after a character in Chinese cartoons). Hobbie-J was +able to remember novel facts (such as the location of toys) three times" +"longer than the genetically modified strain of mouse previously thought +to be the smartest. “This adds to the notion that NR2B is a universal +switch for memory formation,” remarked Dr. Tsien. “It’s like taking +Michael Jordon and making him a super Michael Jordan,” said graduate +student Deheng Wang. + +There are limits, however, even to this new mice strain. When these +mice were given a choice to take a left or right turn to get a chocolate +reward, Hobbie-J was able to remember the correct path for much +longer than the normal mice, but after five minutes he, too, forgot. “We +can never turn it into a mathematician. They are rats, after all,” says Dr. +Tsien. + +It should also be pointed out that some of the strains of smart mice +were exceptionally timid compared to normal mice. Some suspect that, if +your memory becomes too great, you also remember all the failures and +hurts as well, perhaps making you hesitant. So there is also a potential +downside to remembering too much." +"Next, scientists hope to generalize their results to dogs, since we share +so many genes, and perhaps also to humans. + +SMART FLIES AND DUMB MICE + +The NR2B gene is not the only gene being studied by scientists for its +impact on memory. In yet another groundbreaking series of experiments, +scientists have been able to breed a strain of fruit flies with +“photographic memory,” and also a strain of mice that are amnesiac. +These experiments may eventually explain many mysteries of our long¬ +term memory, such as why cramming for an exam is not the best way to + + study, and why we remember events if they are emotionally charged. +Scientists have found that there are two important genes, the CREB +activator (which stimulates the formation of new connections between +neurons) and the CREB repressor (which suppresses the formation of +new memories)." +"Dr. Jerry Yin and Timothy Tully of Cold Spring Harbor have been +doing interesting experiments with fruit flies. Normally it takes ten trials +for them to learn a certain task (e.g., detecting an odor, avoiding a +shock). Fruit flies with an extra CREB repressor gene could not form + +lasting memories at all, but the real surprise came when they tested fruit +flies with an extra CREB activator gene. They learned the task in just one +session. “This implies these flies have a photographic memory,” says Dr. +Tully. He said they are just like students “who could read a chapter of a +book once, see it in their mind, and tell you that the answer is in +paragraph three of page two seventy-four.”" +"This effect is not just restricted to fruit flies. Dr. Alcino Silva, also at +Cold Spring Harbor, has been experimenting with mice. He found that +mice with a defect in their CREB activator gene were virtually incapable +of forming long-term memories. They were amnesiac mice. But even +these forgetful mice could learn a bit if they had short lessons with rest +in between. Scientists theorize that we have a fixed amount of CREB +activator in the brain that can limit the amount we can learn in any +specific time. If we try to cram before a test, it means that we quickly +exhaust the amount of CREB activators, and hence we cannot learn any +more—at least until we take a break to replenish the CREB activators. + +“We can now give you a biological reason why cramming doesn’t +work,” says Dr. Tully. The best way to prepare for a final exam is to +mentally review the material periodically during the day, until the +material becomes part of your long-term memory." +"This may also explain why emotionally charged memories are so vivid +and can last for decades. The CREB repressor gene is like a filter, +cleaning out useless information. But if a memory is associated with a +strong emotion, it can either remove the CREB repressor gene or increase +levels of the CREB activator gene. + +In the future, we can expect more breakthroughs in understanding the +genetic basis of memory. Not just one but a sophisticated combination of +genes is probably required to shape the enormous capabilities of the +brain. These genes, in turn, have counterparts in the human genome, so +it is a distinct possibility that we can also enhance our memory and +mental skills genetically." +"However, don’t think that you will be able to get a brain boost +anytime soon. Many hurdles still remain. First, it is not clear if these +results apply to humans. Often therapies that show great promise in +mice do not translate well to our species. Second, even if these results +can be applied to humans, we do not know what their impact will be. +For example, these genes may help improve our memory but not affect" +"our general intelligence. Third, gene therapy (i.e., fixing broken genes) is +more difficult than previously thought. Only a small handful of genetic +diseases can be cured with this method. Even though scientists use +harmless viruses to infect cells with the “good” gene, the body still sends +antibodies to attack the intruder, often rendering the therapy useless. It’s +possible that the insertion of a gene to enhance memory would face a +similar fate. (In addition, the field of gene therapy suffered a major +setback a few years ago when a patient died at the University of +Pennsylvania during a gene therapy procedure. The work of modifying +human genes therefore faces many ethical and even legal questions.)" +"Human trials, then, will progress much more slowly than animal trials. +However, one can foresee the day when this procedure might be +perfected and become a reality. Altering our genes in this way would +require no more than a simple shot in the arm. A harmless virus would +then enter our blood, which would then infect normal cells by injecting +its genes. Once the “smart gene” is successfully incorporated into our +cells, the gene becomes active and releases proteins that would increase +our memory and cognitive skills by affecting the hippocampus and +memory formation. + +If the insertion of genes becomes too difficult, another possibility is to +insert the proper proteins directly into the body, bypassing the use of +gene therapy. Instead of getting a shot, we would swallow a pill. + +A SMART PILL" +"A SMART PILL + +Ultimately, one goal of this research is to create a “smart pill” that could +boost concentration, improve memory, and maybe increase our +intelligence. Pharmaceutical companies have experimented with several +drugs, such as MEM 1003 and MEM 1414, that do seem to enhance +mental function. + +Scientists have found that in animal studies, long-term memories are +made possible by the interaction of enzymes and genes. Learning takes +place when certain neural pathways are reinforced as specific genes are +activated, such as the CREB gene, which in turn emits a corresponding +protein. Basically, the more CREB proteins circulating in the brain, the + + faster long-term memories are formed. This has been verified in studies + +on sea mollusks, fruit flies, and mice. The key property of MEM 1414 is +that it accelerates the production of the CREB proteins. In lab tests, aged +animals given MEM 1414 were able to form long-term memories +significantly faster than a control group." +"Scientists are also beginning to isolate the precise biochemistry +required in the formation of long-term memories, at both the genetic and +the molecular level. Once the process of memory formation is completely +understood, therapies will be devised to accelerate and strengthen this +key process. Not only the aged and Alzheimer’s patients but eventually +the average person may well benefit from this “brain boost.” + +CAN MEMORIES BE ERASED?" +"CAN MEMORIES BE ERASED? + +Alzheimer’s may destroy memories indiscriminately, but what about +selectively erasing them? Amnesia is one of Hollywood’s favorite plot +devices. In The Bourne Identity, Jason Bourne (played by Matt Damon), a +skilled CIA agent, is found floating in the water, left for dead. When he +is revived, he has severe memory loss. He is being relentlessly chased by +assassins who want to kill him, but he does not know who he is, what +happened, or why they want him dead. The only clue to his memory is +his uncanny ability to instinctively engage in combat like a secret agent." +"It is well documented that amnesia can occur accidentally through +trauma, such as a blow on the head. But can memories be selectively +erased? In the film Eternal Sunshine of the Spotless Mind, starring Jim +Carrey, two people meet accidentally on a train and are immediately +attracted to each other. However, they are shocked to find that they +were actually lovers years ago but have no memory of it. They learn that +they paid a company to wipe memories of each other after a particularly +bad fight. Apparently, fate has given them a second chance at love. + +Selective amnesia was taken to an entirely new level in Men in Black, +in which Will Smith plays an agent from a shadowy, secret organization +that uses the “neuralizer” to selectively erase inconvenient memories of +UFOs and alien encounters. There is even a dial to determine how far +back the memories should be erased. + +All these make for thrilling plot lines and box-office hits, but are any +of them really possible, even in the future?" +"We know that amnesia is, indeed, possible, and that there are two +basic types, depending on whether short- or long-term memory has been +affected. “Retrograde amnesia” occurs when there is some trauma or +damage to the brain and preexisting memories are lost, usually dating +from the event that caused the amnesia. This would be similar to the +amnesia faced by Jason Bourne, who lost all memories from before he +was left for dead in the water. Here the hippocampus is still intact, so +new memories can be formed even though long-term memory has been +damaged. “Anterograde amnesia” occurs when short-term memory is +damaged, so the person has difficulty forming new memories after the +event that caused the amnesia. Usually, amnesia may last for minutes to +hours due to damage to the hippocampus. (Anterograde amnesia was +featured prominently in the movie Memento, where a man is bent on +revenge for the death of his wife. The problem, however, is that his" +"revenge for the death of his wife. The problem, however, is that his +memory lasts only about fifteen minutes, so he has to continually write +messages on scraps of papers, photos, and even tattoos in order to +remember the clues he has uncovered about the murderer. By painfully +reading this trail of messages he has written to himself, he can +accumulate crucial evidence that he would have soon forgotten.)" +"The point here is that memory loss dates back to the time of the +trauma or disease, which would make the selective amnesia of +Hollywood highly improbable. Movies like Men in Black assume that +memories are stored sequentially, as in a hard disk, so you just hit the +“erase” button after a designated point in time. However, we know that +memories are actually broken up, with separate pieces stored in different +places in the brain. + +A FORGETFUL DRUG + +Meanwhile, scientists are studying certain drugs that may erase +traumatic memories that continue to haunt and disturb us. In 2009, +Dutch scientists, led by Dr. Merel Kindt, announced that they had found +new uses for an old drug called propranolol, which could act like a +“miracle” drug to ease the pain associated with traumatic memories. The +drug did not induce amnesia that begins at a specific point in time, but it +did make the pain more manageable—and in just three days, the study + +claimed." +"claimed. + +The discovery caused a flurry of headlines, in light of the thousands of +victims who suffer from PTSD (post-traumatic stress disorder). Everyone +from war veterans to victims of sexual abuse and horrific accidents could +apparently find relief from their symptoms. But it also seemed to fly in +the face of brain research, which shows that long-term memories are" +"encoded not electrically, but at the level of protein molecules. Recent +experiments, however, suggest that recalling memories requires both the +retrieval and then the reassembly of the memory, so that the protein +structure might actually be rearranged in the process. In other words, +recalling a memory actually changes it. This may be the reason why the +drug works: propranolol is known to interfere with adrenaline +absorption, a key in creating the long-lasting, vivid memories that often +result from traumatic events. “Propranolol sits on that nerve cell and +blocks it. So adrenaline can be present, but it can’t do its job,” says Dr. +James McGaugh of the University of California at Irvine. In other words, +without adrenaline, the memory fades." +"Controlled tests done on individuals with traumatic memories showed +very promising results. But the drug hit a brick wall when it came to the +ethics of erasing memory. Some ethicists did not dispute its +effectiveness, but they frowned on the very idea of a forgetfulness drug, +since memories are there for a purpose: to teach us the lessons of life. +Even unpleasant memories, they said, serve some larger purpose. The +drug got a thumbs-down from the President’s Council on Bioethics. Its +report concluded that “dulling our memory of terrible things [would] +make us too comfortable with the world, unmoved by suffering, +wrongdoing, or cruelty.... Can we become numb to life’s sharpest +sorrows without also becoming numb to its greatest joys?” + +Dr. David Magus of Stanford University’s Center for Biomedical Ethics +says, “Our breakups, our relationships, as painful as they are, we learn +from some of those painful experiences. They make us better people.”" +"Others disagree. Dr. Roger Pitman of Harvard University says that if a +doctor encounters an accident victim who is in intense pain, “should we +deprive them of morphine because we might be taking away the full +emotional experience? Who would ever argue with that? Why should +psychiatry be different? I think that somehow behind this argument +lurks the notion that mental disorders are not the same as physical + +disorders.” + +How this debate is ultimately resolved could have direct bearing on +the next generation of drugs, since propranolol is not the only one +involved. + +In 2008, two independent groups, both working with animals, +announced other drugs that could actually erase memories, not just +manage the pain they cause. Dr. Joe Tsien of the Medical College of +Georgia and his colleagues in Shanghai stated that they had actually +eliminated a memory in mice using a protein called CaMKII, while +scientists at SUNY Downstate Medical Center in Brooklyn found that the" +"molecule PKMzeta could also erase memories. Dr. Andre Fenson, one of +the authors of this second study, said, “If further work confirms this +view, we can expect to one day see therapies based on PKMzeta memory +erasure.” Not only may the drug erase painful memories, it also “might +be useful in treating depression, general anxiety, phobias, post-traumatic +stress, and addictions,” he added. + +So far, research has been limited to animals, but human trials will +begin soon. If the results transfer from animals to humans, then a +forgetful pill may be a real possibility. It will not be the kind of pill seen +in Hollywood movies (which conveniently creates amnesia at a precise, +opportune time) but could have vast medical applications in the real +world for people haunted by traumatic memories. It remains to be seen, +though, how selective this memory erasure might be in humans. + +WHAT CAN GO WRONG?" +"WHAT CAN GO WRONG? + +There may come a day, however, when we can carefully register all the +signals passing through the hippocampus, thalamus, and the rest of the +limbic system and make a faithful record. Then, by feeding this +information into our brains, we might be able to reexperience the +totality of what another person went through. Then the question is: +What can go wrong? + +In fact, the implications of this idea were explored in a movie, +Brainstorm (1983), starring Natalie Wood, which was far ahead of its +time. In the movie, scientists create the Hat, a helmet full of electrodes +that can faithfully record all the sensations a person is experiencing." +"Later, a person can have precisely the same sensory experience by +playing that tape back into his brain. For fun, one person puts on the Hat +when he is making love and tape-records the experience. Then the tape +is put into a loop so the experience is greatly magnified. But when +another person unknowingly inserts the experience into his brain, he +nearly dies because of a sensory overload. Later, one of the scientists +experiences a fatal heart attack. But before she dies, she records her final +moments on tape. When another person plays the death tape into his +brain, he, too, has a sudden heart attack and dies. + +When news of this powerful machine finally leaks out, the military +wants to seize control. This sets off a power struggle between the +military, which views it as a powerful weapon, and the original +scientists, who want to use it to unlock the secrets of the mind. + +Brainstorm prophetically highlighted not only the promise of this" +"Brainstorm prophetically highlighted not only the promise of this + + technology but also its potential pitfalls. It was meant to be science +fiction, but some scientists believe that sometime in the future, these +very issues may play out in our headlines and in our courts. + +Earlier, we saw that there have been promising developments in +recording a single memory created by a mouse. It may take until mid¬ +century before we can reliably record a variety of memories in primates +and humans. But creating the Hat, which can record the totality of +stimulation entering into the brain, requires tapping into the raw, +sensory data surging up the spinal cord and into the thalamus. It may be +late in this century before this can be done. + +SOCIAL AND LEGAL ISSUES" +"SOCIAL AND LEGAL ISSUES + +Some aspects of this dilemma may play out in our lifetimes. On one +hand, we may reach a point where we can learn calculus by simply +uploading the skill. The educational system would be turned upside +down; perhaps it would free teachers to spend more time mentoring +students and giving them one-on-one attention in areas of cognition that +are less skill-based and cannot be mastered by hitting a button. The rote +memorization necessary to become a professional doctor, lawyer, or +scientist could also be drastically reduced through this method. + +In principle, it might even give us memories of vacations that never" +"In principle, it might even give us memories of vacations that never + +happened, prizes that we never won, lovers whom we never loved, or +families that we never had. It could make up for deficiencies, creating +perfect memories of a life never lived. Parents would love this, since +they could teach their children lessons taken from real memories. The +demand for such a device could be enormous. Some ethicists fear that +these fake memories would be so vivid that we would prefer to relive +imaginary lives rather than experiencing our real ones." +"The unemployed may also benefit from being able to learn new +marketable skills by having memories implanted. Historically, millions +of workers were left behind every time a new technology was +introduced, often without any safety net. That’s why we don’t have +many blacksmiths or wagon makers anymore. They turned into +autoworkers and other industrial workers. But retraining requires a large +amount of time and commitment. If skills can be implanted into the +brain, there would be an immediate impact on the world economic +system, since we wouldn’t have to waste so much human capital. (To +some degree, the value of a certain skill may be devalued if memories +can be uploaded into anyone, but this is compensated for by the fact that +the number and quality of skilled workers would vastly increase.)" +"The tourism industry will also experience a tremendous boost. One +barrier to foreign travel is the pain of learning new customs and +conversing with new phrases. Tourists would be able to share in the +experience of living in a foreign land, rather than getting bogged down +trying to master the local currency and the details of the transportation +system. (Although uploading an entire language, with tens of thousands +of words and expressions, would be difficult, it might be possible to +upload enough information to carry on a decent conversation.)" +"Inevitably, these memory tapes will find their way onto social media. +In the future, you might be able to record a memory and upload it to the +Internet for millions to feel and experience. Previously, we discussed a +brain-net through which you can send thoughts. But if memories can be +recorded and created, you might also be able to send entire experiences. +If you just won a gold medal at the Olympic Games, why not share the +agony and the ecstasy of victory by putting your memories on the web? +Maybe the experience will go viral and billions can share in your +moment’s glory. (Children, who are often at the forefront of video games +and social media, may make a habit of recording memorable experiences" +"and uploading them onto the Internet. Like taking a picture with a cell +phone, it would be second nature to them to record entire memories. +This would require both the sender and the receiver to have nearly +invisible nanowires connecting to their hippocampus. The information +would then be sent wirelessly to a server, which would convert the +message to a digital signal that can be carried by the Internet. In this +way, you could have blogs, message boards, social media, and chat +rooms where, instead of uploading pictures and videos, you would +upload memories and emotions.) + +A LIBRARY OF SOULS" +"A LIBRARY OF SOULS + +People may also want to have a geneology of memories. When searching +records of our ancestors, we see only a one-dimensional portrait of their +lives. Throughout human history, people have lived, loved, and died +without leaving a substantial record of their existence. Mostly we just +find the birth and death dates of our relatives, with little in between. +Today we leave a long trail of electronic documents (credit card receipts, +bills, e-mails, bank statements, etc.). By default, the web is becoming a +giant repository of all the documents that describe our lives, but this still +doesn’t tell anyone much about what we were thinking or feeling. +Perhaps in the far future, the web could become a giant library +chronicling not just the details of our lives but also our consciousness." +"In the future, people might routinely record their memories so their +descendants can share the same experiences. Visiting the library of +memories for your clan, you would be able to see and feel how they +lived, and also how you fit into the larger scheme of things. + +This means that anyone could replay our lives, long after we have +died, by hitting the “play” button. If this vision is correct, it means that +we might be able to “bring back” our ancestors for an afternoon chat, +simply by inserting a disk into the library and pushing a button. + +Meanwhile, if you want to share in the experiences of your favorite +historical figures, you might be able to have an intimate look into how +they felt as they confronted major crises in their lives. If you have a role +model and wish to know how they negotiated and survived the great +defeats of their life, you could experience their memory tapes and gain" +"valuable insight. Imagine being able to share the memories of a Nobel +Prize-winning scientist. You might get clues about how great discoveries +are made. Or you might be able to share the memories of great +politicians and statesmen as they made crucial decisions that affected +world history. + +Dr. Miguel Nicolelis believes all this will one day become reality. He +says, “Each of these perennial records would be revered as a uniquely +precious jewel, one among billions of equally exclusive minds that once +lived, loved, suffered, and prospered, until they, too, become +immortalized, not clad in cold and silent gravestones, but released +through vivid thoughts, intensely lived loves, and mutually endured +sorrows.” + +THE DARK SIDE OF TECHNOLOGY" +"THE DARK SIDE OF TECHNOLOGY + +Some scientists have pondered the ethical implications of this +technology. Almost every new medical discovery caused ethical concerns +when it was introduced. Some of them had to be restricted or banned +when proven harmful (like the sleeping drug thalidomide, which caused +birth defects). Others have been so successful they changed our +conception of who we are, such as test-tube babies. When Louise Brown, +the first test-tube baby, was born in 1978, it created such a media storm +that even the pope issued a document critical of this technology. But +today, perhaps your sibling, child, spouse, or even you may be a product +of in vitro fertilization. Like many technologies, eventually the public +will simply get used to the idea that memories can be recorded and +shared." +"Other bioethicists have different worries. What happens if memories +are given to us without our permission? What happens if these memories +are painful or destructive? Or what about Alzheimer’s patients, who are +eligible for memory uploads but are too sick to give permission? + +The late Bernard Williams, a philosopher at Oxford University, +worried that this device might disturb the natural order of things, which +is to forget. “Forgetting is the most beneficial process we possess,” he +says. + +If memories can be implanted like uploading computer files, it could" +"If memories can be implanted like uploading computer files, it could + +also shake the foundation of our legal system. One of the pillars of +justice is the eyewitness account, but what would happen if fake +memories were implanted? Also, if the memory of a crime can be +created, then it might secretly be implanted into the brain of an innocent +person. Or, if a criminal needs an alibi, he could secretly implant a +memory into another person’s brain, convincing him that they were +together when the crime was being committed. Furthermore, not just +verbal testimony but also legal documents would be suspect, since when +we sign affidavits and legal documents, we depend on our memory to +clarify what is true and false." +"Safeguards would have to be introduced. Laws will have to be passed +that clearly define the limits of granting or denying access to memories. +Just as there are laws limiting the ability of the police or third parties to +enter your home, there would be laws to prevent people from accessing +your memories without your permission. There would also have to be a +way to mark these memories so that the person realizes that they are +fake. Thus, he would still be able to enjoy the memory of a nice +vacation, but he would also know that it never happened." +"Taping, storing, and uploading our memories may allow us to record +the past and master new skills. But doing so will not alter our innate +ability to digest and process this large body of information. To do that, +we need to enhance our intelligence. Progress in this direction is +hindered by the fact that there is no universally accepted definition of +intelligence. However, there is one example of genius and intelligence +that no one can dispute, and that is Albert Einstein. Remarkably, sixty +years after his death, his brain is still yielding invaluable clues to the +nature of intelligence. + +Some scientists believe that, using a combination of electromagnetics, +genetics, and drug therapy, it may be possible to boost our intelligence +to the genius level. They cite the fact that random injuries to the brain +have been documented that can suddenly change a person of normal +ability into a “savant,” one whose spectacular mental and artistic ability" +"is off the scale. This can be achieved now by random accidents, but what +happens when science intervenes and illuminates the secret of this +process? + +The brain is wider than the sky +For, put them side by side +The one the other will contain +With ease, and you beside. + +—EMILY DICKINSON + +Talent hits a target no one else can hit. Genius hits a target no +one else can see. + +—ARTHUR SCHOPENHAUER + +6 EINSTEIN’S BRAIN AND ENHANCING OUR +INTELLIGENCE + +Albert Einstein’s brain is missing. + +Or, at least it was for fifty years, until the heirs of the doctor who +spirited it away shortly after his death in 1955 finally returned it to the +National Museum of Health and Medicine in 2010. Analysis of his brain +may help clarify these questions: What is genius? How do you measure +intelligence and its relationship to success in life? There are also +philosophical questions: Is genius a function of our genes, or is it more a +question of personal struggle and achievement?" +"And, finally, Einstein’s brain may help answer the key question: Can +we boost our own intelligence? + +The word “Einstein” is no longer a proper noun that refers to a specific +person. It now simply means “genius.” The picture that the name +conjures up (baggy pants, flaming white hair, disheveled looks) is +equally iconic and instantly recognizable. + +The legacy of Einstein has been enormous. When some physicists in +2011 raised the possibility that he was wrong, that particles could break +the light barrier, it created a firestorm of controversy in the physics +world that spilled over into the popular press. The very idea that +relativity, which forms the cornerstone of modern physics, could be +wrong had physicists around the world shaking their heads. As expected, +once the result was recalibrated, Einstein was shown to be right once + + again. It is always dangerous to go up against Einstein." +"again. It is always dangerous to go up against Einstein. + +One way to gain insight into the question “What is genius?” is to +analyze Einstein’s brain. Apparently on the spur of the moment, Dr. +Thomas Harvey, the doctor at the Princeton hospital who was +performing the autopsy on Einstein, decided to secretly preserve his +brain, against the knowledge and wishes of Einstein’s family. + +Perhaps he preserved Einstein’s brain with the vague notion that one +day it might unlock the secret of genius. Perhaps he thought, like many + +others, that there was a peculiar part of Einstein’s brain that was the seat +of his vast intelligence. Brian Burrell, in his book Postcards from the Brain +Museum, speculates that perhaps Dr. Harvey “got caught up in the +moment and was transfixed in the presence of greatness. What he +quickly discovered was that he had bitten off more than he could chew.”" +"What happened to Einstein’s brain after that sounds more like a +comedy than a science story. Over the years, Dr. Harvey promised to +publish his results of analyzing Einstein’s brain. But he was no brain +specialist, and kept making excuses. For decades, the brain sat in two +large mason jars filled with formaldehyde and placed in a cider box, +under a beer cooler. He had a technician slice the brain into 240 pieces, +and on rare occasions he would mail a few to scientists who wanted to +study them. Once, pieces were mailed to a scientist at Berkeley in a +mayonnaise container." +"Forty years later, Dr. Harvey drove across the country in a Buick +Skylark carrying Einstein’s brain in a Tupperware container, hoping to +return it to Einstein’s granddaughter Evelyn. She refused to accept it. +After Dr. Harvey’s death in 2007, it was left to his heirs to properly +donate his collection of slides and portions of Einstein’s brain to science. +The history of Einstein’s brain is so unusual that a TV documentary was +filmed about it. + +(It should be pointed out that Einstein’s brain was not the only one to +be preserved for posterity. The brain of one of the greatest geniuses of +mathematics, Carl Friedrich Gauss, often called the Prince of +Mathematicians, was also preserved by a doctor a century earlier. Back +then, the anatomy of the brain was largely unexplored, and no +conclusions could be drawn other than the fact that it had unusually +large convolutions or folds.)" +"One might expect that Einstein’s brain was far beyond an ordinary +human’s, that it must have been huge, perhaps with areas that were +abnormally large. In fact, the opposite has been found (it is slightly +smaller, not larger, than normal). Overall, Einstein’s brain is quite + + ordinary. If a neurologist did not know that this was Einstein’s brain, he +probably would not give it a second thought. + +The only differences found in Einstein’s brain were rather minor. A +certain part of his brain, called the angular gyri, was larger than normal, +with the inferior parietal regions of both hemispheres 15 percent wider" +"than average. Notably, these parts of the brain are involved in abstract +thought, in the manipulation of symbols such as writing and +mathematics, and in visual-spatial processing. But his brain was still +within the norm, so it is not clear whether the genius of Einstein lay in +the organic structure of his brain or in the force of his personality, his +outlook, and the times. In a biography that I once wrote of Einstein, +titled Einstein’s Cosmos, it was clear to me that certain features of his life +were just as important as any anomaly in his brain. Perhaps Einstein +himself said it best when he said, “I have no special talents.... I am only +passionately curious.” In fact, Einstein would confess that he had to +struggle with mathematics in his youth. To one group of schoolchildren, +he once confided, “No matter what difficulties you may have with +mathematics, mine were greater.” So why was Einstein Einstein?" +"First, Einstein spent most of his time thinking via “thought +experiments.” He was a theoretical physicist, not an experimental one, +so he was continually running sophisticated simulations of the future in +his head. In other words, his laboratory was his mind." +"Second, he was known to spend up to ten years or more on a single +thought experiment. From the age of sixteen to twenty-six, he focused on +the problem of light and whether it was possible to outrace a light beam. +This led to the birth of special relativity, which eventually revealed the +secret of the stars and gave us the atomic bomb. From the age of twenty- +six to thirty-six, he focused on a theory of gravity, which eventually gave +us black holes and the big-bang theory of the universe. And then from +the age of thirty-six to the end of his life, he tried to find a theory of +everything to unify all of physics. Clearly, the ability to spend ten or +more years on a single problem showed the tenacity with which he +would simulate experiments in his head." +"Third, his personality was important. He was a bohemian, so it was +natural for him to rebel against the establishment in physics. Not every +physicist had the nerve or the imagination to challenge the prevailing +theory of Isaac Newton, which had held sway for two hundred years +before Einstein. + +Fourth, the time was right for the emergence of an Einstein. In 1905, +the old physical world of Newton was crumbling in light of experiments +that clearly suggested a new physics was about to be born, waiting for a + + genius to show the way. For example, the mysterious substance called + +radium glowed in the dark all by itself indefinitely, as if energy was +being created out of thin air, violating the theory of conservation of +energy. In other words, Einstein was the right man for the times. If +somehow it becomes possible to clone Einstein from the cells in his +preserved brain, I suspect that the clone would not be the next Einstein. +The historic circumstances must also be right to create a genius." +"The point here is that genius is perhaps a combination of being born +with certain mental abilities and also the determination and drive to +achieve great things. The essence of Einstein’s genius was probably his +extraordinary ability to simulate the future through thought +experiments, creating new physical principles via pictures. As Einstein +himself once said, “The true sign of intelligence is not knowledge, but +imagination.” And to Einstein, imagination meant shattering the +boundaries of the known and entering the domain of the unknown. + +All of us are born with certain abilities that are programmed into our +genes and the structure of our brains. That is the luck of the draw. But +how we arrange our thoughts and experiences and simulate the future is +something that is totally within our control. Charles Darwin himself once +wrote, “I have always maintained that, excepting fools, men did not +differ much in intellect, only in zeal and hard work.” + +CAN GENIUS BE LEARNED?" +"CAN GENIUS BE LEARNED? + +This rekindles the question, Are geniuses made or born? How does the +nature/nurture debate solve the mystery of intelligence? Can an ordinary +person become a genius? + +Since brain cells are notoriously hard to grow, it was once thought +that intelligence was fixed by the time we became young adults. But one +thing is becoming increasingly clear with new brain research: the brain +itself can change when it learns. Although brain cells are not being +added in the cortex, the connections between neurons are changing +every time a new task is learned. + +For example, scientists in 2011 analyzed the brains of London’s +famous taxicab drivers, who have to laboriously memorize twenty-five +thousand streets in the dizzying maze that makes up modern London. It +takes three to four years to prepare for this arduous test, and only half + + the trainees pass." +"the trainees pass. + +Scientists at University College London studied the brains of these +drivers before they took the test, and then tested them again three to +four years afterward. Those trainees who passed the test had a larger +volume of gray matter than before, in an area called the posterior and +the anterior hippocampus. The hippocampus, as we’ve seen, is where +memories are processed. (Curiously, tests also showed that these taxicab +drivers scored less than normal on processing visual information, so +perhaps there is a trade-off, a price to pay for learning this volume of +information.) + +“The human brain remains ‘plastic,’ even in adult life, allowing it to +adapt when we learn new tasks,” says Eleanor Maguire of the Wellcome +Trust, which funded the study. “This offers encouragement for adults +who want to learn new skills later in life.”" +"Similarly, the brains of mice that have learned many tasks are slightly +different from the brains of other mice that have not learned these tasks. +It is not so much that the number of neurons has changed, but rather +that the nature of the neural connections has been altered by the +learning process. In other words, learning actually changes the structure +of the brain. + +This raises the old adage “practice makes perfect.” Canadian +psychologist Dr. Donald Hebb discovered an important fact about the +wiring of the brain: the more we exercise certain skills, the more certain +pathways in our brains become reinforced, so the task becomes easier. +Unlike a digital computer, which is just as dumb today as it was +yesterday, the brain is a learning machine with the ability to rewire its +neural pathways every time it learns something. This is a fundamental +difference between a digital computer and the brain." +"This lesson applies not only to London taxicab drivers, but also to +accomplished concert musicians as well. According to psychologist Dr. K. +Anders Ericsson and colleagues, who studied master violinists at Berlin’s +elite Academy of Music, top concert violinists could easily rack up ten +thousand hours of grueling practice by the time they were twenty years +old, practicing more than thirty hours per week. By contrast, he found +that students who were merely exceptional studied only eight thousand +hours or fewer, and future music teachers practiced only a total of four +thousand hours. Neurologist Daniel Levitin says, “The emerging picture + +from such studies is that ten thousand hours of practice is required to +achieve the level of mastery associated with being a world-class expert— +in anything.... In study after study, of composers, basketball players, +fiction writers, ice skaters, concert pianists, chess players, master" +"criminals, and what have you, this number comes up again and again.” +Malcolm Gladwell, writing in the book Outliers, calls this the “10,000- +hour rule.” + +HOW DO YOU MEASURE INTELLIGENCE? + +But how do you measure intelligence? For centuries, any discussion of +intelligence relied on hearsay and anecdote. But now MRI studies have +shown that the principal activity of the brain while performing these +mathematical puzzles involves the pathway connecting the prefrontal +cortex (which engages in rational thought) with the parietal lobes +(which processes numbers). This correlates with the anatomical studies +of Einstein’s brain, which showed that his inferior parietal lobes were +larger than normal. So it is conceivable that mathematical ability +correlates with increased information flows between the prefrontal +cortex and the parietal lobes. But did the brain increase in size in this +area because of hard work and study, or was Einstein born that way? +The answer is still not clear." +"The key problem is that there is no uniformly accepted definition of +intelligence, let alone a consensus among scientists as to its origin. But +the answer may prove critical if we wish to enhance it. + +IQ EXAMS AND DR. TERMAN + +By default, the most widely used measure of intelligence is the IQ exam, +pioneered by Dr. Lewis Terman of Stanford University, who in 1916 +revised an earlier test devised by Alfred Binet for the French +government. For the next several decades, it became the gold standard +by which to measure intelligence. Terman, in fact, dedicated his life to +the proposition that intelligence could be measured and inherited, and +was the strongest predictor of success in life. + +Five years later, Terman started a landmark study on schoolchildren," +"Five years later, Terman started a landmark study on schoolchildren, + +The Genetic Studies of Genius. It was an ambitious project, whose scope +and duration were unprecedented back in the 1920s. It set the tone for +research in this field for an entire generation. He methodically +chronicled the successes and failures of these individuals throughout +their lives, compiling thick files of their achievements. These high-IQ +students were dubbed the “Termites.” + +At first, Dr. Terman’s idea seemed to be a resounding success. It" +"At first, Dr. Terman’s idea seemed to be a resounding success. It + + became the standard by which both children and other tests were +measured. During World War I, 1.7 million soldiers were given this test. +But over the years, a different profile began to slowly emerge. Decades +later, children who scored high on the IQ exam were only moderately +more successful than those who did not. Terman could proudly point to +some of his students who went on to win awards and secure well-paying +jobs. But he became increasingly disturbed by the large number of his +brightest students whom society would consider to be failures, taking +menial, dead-end jobs, engaging in crime, or leading lives on the +margins of society. These results were quite upsetting to Dr. Terman, +who had dedicated his life to proving that high IQ meant success in life. + +SUCCESS IN LIFE AND DELAYED GRATIFICATION" +"SUCCESS IN LIFE AND DELAYED GRATIFICATION + +A different approach was taken in 1972 by Dr. Walter Mischel, also of +Stanford, who analyzed yet another characteristic among children: the +ability to delay gratification. He pioneered the use of the “marshmallow +test,” that is, would children prefer one marshmallow now, or the +prospect of two marsh-mallows twenty minutes later? Six hundred +children, aged four to six, participated in this experiment. When Mischel +revisited the participants in 1988, he found that those who could delay +gratification were more competent than those who could not." +"In 1990, another study showed a direct correlation between those who +could delay gratification and SAT scores. And a study done in 2011 +indicated that this characteristic continued throughout a person’s life. +The results of these and other studies were eye-opening. The children +who exhibited delayed gratification scored higher on almost every +measure of success in life: higher-paying jobs, lower rates of drug +addiction, higher test scores, higher educational attainment, better social + +integration, etc." +"integration, etc. + +But what was most intriguing was that brain scans of these individuals +revealed a definite pattern. They showed a distinct difference in the way +the prefrontal cortex interacted with the ventral striatum, a region +involved in addiction. (This is not surprising, since the ventral striatum +contains the nucleus accumbens, known as the “pleasure center.” So +there seems to be a struggle here between the pleasure-seeking part of +the brain and the rational part to control temptation, as we saw in +Chapter 2.) + +This difference was no fluke. The result has been tested by many +independent groups over the years, with nearly identical results. Other +studies have also verified the difference in the frontal-striatal circuitry of + + the brain, which appears to govern delayed gratification. It seems that +the one characteristic most closely correlated with success in life, which +has persisted over the decades, is the ability to delay gratification." +"Although this is a gross simplification, what these brain scans show is +that the connection between the prefrontal and parietal lobes seems to +be important for mathematical and abstract thought, while the +connection between the prefrontal and limbic system (involving the +conscious control of our emotions and pleasure center) seems to be +essential for success in life. + +Dr. Richard Davidson, a neuroscientist at the University of Wisconsin- +Madison, concludes, “Your grades in school, your scores on the SAT, +mean less for life success than your capacity to co-operate, your ability +to regulate your emotions, your capacity to delay your gratification, and +your capacity to focus your attention. Those skills are far more +important—all the data indicate—for life success than your IQ or your +grades.” + +NEW MEASURES OF INTELLIGENCE" +"NEW MEASURES OF INTELLIGENCE + +Clearly there have to be new ways to measure intelligence and success in +life. IQ exams are not useless, but they measure only one limited form of +intelligence. Dr. Michael Sweeney, author of Brain: The Complete Mind, +notes, “Tests don’t measure motivation, persistence, social skills, and a +host of other attributes of a life that’s well lived.”" +"The problem with many of these standardized tests is that there may +also be a subconscious bias due to cultural influences. In addition, these +tests are evaluating only one particular form of intelligence, which some +psychologists call “convergent” intelligence. Convergent intelligence +focuses on one line of thought, ignoring the more complex “divergent” +form of intelligence, which involves measuring differing factors. For +example, during World War II, the U.S. Army Air Forces asked scientists +to devise a psychological exam that would measure a pilot’s intelligence +and ability to handle difficult, unexpected situations. One question was: +If you are shot down deep in enemy territory and must somehow make it +back to friendly lines, what do you do? The results contradicted +conventional thinking." +"Most psychologists expected that the air force study would show that +pilots with high IQs would score highly on this test as well. Actually, the +reverse was true. The pilots who scored highest were the ones with +higher levels of divergent thinking, who could see through many +different lines of thought. Pilots who excelled at this, for example, were +able to think up a variety of unorthodox and imaginative methods to + + escape after they were captured behind enemy lines." +"escape after they were captured behind enemy lines. + +The difference between convergent and divergent thinking is also +reflected in studies on split-brain patients, which clearly show that each +hemisphere of the brain is principally hardwired for one or the other. Dr. +Ulrich Kraft of Fulda, Germany, writes, “The left hemisphere is +responsible for convergent thinking and the right hemisphere for +divergent thinking. The left side examines details and processes them +logically and analytically but lacks a sense of overriding, abstract +connections. The right side is more imaginative and intuitive and tends +to work holistically, integrating pieces of an informational puzzle into a +whole.”" +"In this book, I take the position that human consciousness involves the +ability to create a model of the world and then simulate the model into +the future, in order to attain a goal. Pilots who demonstrated divergent +thinking were able to simulate many possible future events accurately +and with more complexity. Similarly, the children who mastered delayed +gratification in the famous marshmallow test appear to be the ones who +had the most ability to simulate the future, to see the long-term rewards +and not just the short-term, get-rich-quick schemes." +"A more sophisticated intelligence exam that directly quantifies a +person’s ability to simulate the future would be difficult but not +impossible to create. A person could be asked to create as many realistic +scenarios for the future as possible to win a game, with a score assigned +depending on the number of simulations the person can imagine and the +number of causal links involved with each one. Instead of measuring a +person’s ability to simply assimilate information, this new method would +measure a person’s ability to manipulate and mold this information to +achieve a higher goal. For example, a person might be asked to figure +out how to escape from a deserted island full of hungry wild animals and +poisonous snakes. He would have to list all the various ways to survive, +fend off the dangerous animals, and leave the island, creating an +elaborate causal tree of possible outcomes and futures." +"So we see that there is a common thread running through all this +discussion, and that is that intelligence seems to be correlated with the +complexity with which we can simulate future events, which correlates +with our earlier discussion of consciousness. + +But given the rapid advances taking place in the world’s laboratories +concerning electromagnetic fields, genetics, and drug therapies, is it +possible not just to measure our intelligence, but to enhance it as well— +to become another Einstein? + + BOOSTING OUR INTELLIGENCE + +This possibility was explored in the novel Flowers for Algernon (1958), +later made into the Academy Award-winning movie Charly (1968). In it, +we follow the sad life of Charly Gordon, who has an IQ of 68 and a +menial job in a bakery. He lives a simple life, fails to understand that his +fellow workers are constantly making fun of him, and does not even +know how to spell his own name." +"His only friend is Alice, a teacher who takes pity on him and tries to +teach him to read. But one day, scientists discover a new procedure that +can suddenly make ordinary mice intelligent. Alice hears about this and +decides to introduce Charly to these scientists, who agree to perform the +procedure on their first human subject. Within weeks, Charly has +noticeably changed. His vocabulary increases, he devours books from the + +library, he becomes something of a ladies’ man, and his room explodes +with modern art. Soon he begins to read about relativity and the +quantum theory, pushing the boundaries of advanced physics. He and +Alice even become lovers." +"But then the doctors notice that the mice have slowly lost their ability +and died. Realizing that he, too, might lose everything, Charly furiously +tries to use his superior intellect to find a cure, but instead he’s forced to +witness his own inexorable decline. His vocabulary shrinks, he forgets +mathematics and physics, and he slowly reverts back to his old self. In +the final scene, a heartbroken Alice watches as Charly plays with +children. + +The novel and movie, although poignant and critically acclaimed, +were dismissed as sheer science fiction. The plot was moving and +original, but the idea of boosting one’s intelligence was considered +preposterous. Brain cells cannot regenerate, scientists said, so this +movie’s plot was obviously impossible. + +But not anymore." +"But not anymore. + +Although it is still impossible to boost your intelligence, rapid +advances are being made in electromagnetic sensors, genetics, and stem +cells that may one day make this a real possibility. In particular, +scientific interest has focused on “autistic savants,” who possess +phenomenal, superhuman abilities that stagger the imagination. More +important, due to specific injuries to the brain, normal people can +rapidly acquire such near-miraculous powers. Some scientists even +believe that these uncanny abilities might be induced using +electromagnetic fields. + + SAVANTS: SUPER GENIUSES? + +A bullet went crashing through the skull of Mr. Z when he was nine +years old. It did not kill him, as his doctors feared, but wreaked +extensive damage to the left side of his brain, causing paralysis of the +right side of his body and leaving him permanently deaf and mute." +"However, the bullet also had a bizarre side effect. Mr. Z developed +supernormal mechanical abilities and a prodigious memory, typical of +“savants.” + +Mr. Z is not alone. In 1979, a ten-year-old boy named Orlando Serrell +was knocked unconscious by a baseball that hit the left side of his head. +At first, he complained of severe headaches. But after the pain subsided, +he was able to do remarkable mathematical calculations and had a near¬ +photographic memory of certain events happening in his life. He could +calculate dates thousands of years into the future. + +In the entire world of roughly seven billion people, there are only +about one hundred documented cases of these astounding savants. (The +number is much larger if we include those whose mental skills are still +extraordinary but not superhuman. It is believed that about 10 percent +of autistic individuals show some savant capabilities.) These +extraordinary savants possess abilities far beyond our current scientific +understanding." +"There are several types of savants that have recently elicited the +curiosity of scientists. About half of savants have some form of autism +(the other half display other forms of mental illness or psychological +disorder). They often have profound problems interacting socially, +leading to deep isolation. + +Then there is the “acquired savant syndrome,” in which people who +appear perfectly normal suffer from some extreme trauma later in life +(e.g., hitting their head on the bottom of a swimming pool or being +struck by a baseball or a bullet), almost always on the left side of their +brain. Some scientists, however, suggest that this distinction is +misleading, that perhaps all savant skills are acquired. Since autistic +savants begin to show their abilities around age three or four, perhaps +their autism (like a blow to their head) is the origin of their abilities." +"There is scientific disagreement about the origin of these extraordinary +abilities. Some believe that these individuals are simply born this way +and hence are unique, one-of-a-kind anomalies. Their skills, even if + + awakened by a bullet, are hardwired into their brains from birth. If so, +then perhaps this skill can never be learned or transferred. + +Others claim that such hardwiring violates the theory of evolution, +which takes place incrementally over long periods of time. If savant +geniuses exist, then the rest of us must also possess similar abilities, +although they are latent. Does this mean, then, that one day we might be +able to turn on these miraculous powers at will? Some believe so, and +there are even published papers claiming that some savant skills are" +"latent in all of us and can be brought to light using the magnetic fields +generated by an electromagnetic scanner (TES). Or perhaps there is a +genetic basis to this skill, in which case gene therapy might re-create +these astonishing abilities. It might also be possible to cultivate stem +cells that would allow neurons to grow in the prefrontal cortex and other +key centers of the brain. Then we might be able to increase our mental +abilities. + +All these avenues are the source of much speculation and research. +Not only might they allow doctors to reverse the ravages of diseases like +Alzheimer’s, but they could also enable us to enhance our own +intelligence. The possibilities are intriguing." +"The first documented case of a savant was recorded in 1789 by Dr. +Benjamin Rush, who studied an individual who seemed to be mentally +handicapped. Yet when he was asked how many seconds a man had +lived (who was seventy years, seventeen days, and twelve hours old), it +took him only ninety seconds to give the correct answer of +2,210,500,800. + +Dr. Darold Treffert, a Wisconsin physician, has studied these savants at +length. He recites one story of a blind savant who was asked a simple +question. If you put one corn kernel in the first square of a chess board, +two kernels in the second, four in the next, and keep doubling after that, +how many kernels would you have on the sixty-fourth square? It took +him just forty-five seconds to correctly reply: +18,446,744,073,709,551,616." +"Perhaps the best-known example of a savant was the late Kim Peek, +who was the inspiration for the movie Rain Man, starring Dustin +Hoffman and Tom Cruise. Although Kim Peek was severely mentally +handicapped (he was incapable of living by himself and could barely tie +his shoelaces or button his shirt), he memorized about twelve thousand +books and could recite lines from them, word for word, on any particular +page. It took him about eight seconds to read a page. (He could +memorize a book in about half an hour, but he read them in an unusual +way. He could read both pages simultaneously, using each eye to read a + + different page at the same time.) Although incredibly shy, he eventually +began to enjoy performing dazzling feats of mathematics before curious +onlookers, who would try to challenge him with tricky questions. + +Scientists, of course, have to be careful in distinguishing true savant" +"skills from simple memorization tricks. Their skills are not just +mathematical—they also extend to incredible musical, artistic, and +mechanical capabilities. Since autistic savants have great difficulty +verbally expressing their mental processes, another avenue is to +investigate individuals who have Asperger’s syndrome, which is a milder +form of autism. Only in 1994 was Asperger’s syndrome recognized as a +distinct psychological condition, so there is very little solid research in +this area. Like autistic individuals, people with Asperger’s have a +difficult time interacting socially with others. However, with proper +training, they can learn enough social skills to hold down a job and +articulate their mental processes. And a fraction of them have +remarkable savant skills. Some scientists believe that many great +scientists had Asperger’s syndrome. This might explain the strange, +reclusive nature of physicists like Isaac Newton and Paul Dirac (one of" +"reclusive nature of physicists like Isaac Newton and Paul Dirac (one of +the founders of the quantum theory). Newton, in particular, was +pathologically incapable of small talk." +"I had the pleasure of interviewing one such individual, Daniel +Tammet, who has written a best seller, Bom on a Blue Day. Almost alone +among these remarkable savants, he is able to articulate his thoughts in +books, on the radio, and in TV interviews. For someone who had such +difficulty relating to others as a child, he now has a superb grasp of +communication skills. + +Daniel has the distinction of setting a world record for memorizing pi, +a fundamental number in geometry. He was able to memorize it to +22,514 decimal places. I asked him how he prepared for such a +herculean feat. Daniel told me that he associates a color or texture with +every number. Then I asked him the key question: If every digit has a +color or texture, then how does he remember tens of thousands of them? +Sadly, at that point he said he doesn’t know. It just comes to him. +Numbers have been his life ever since he was a child, and hence they +simply appear in his mind. His mind is a constant mixture of numbers +and colors." +"ASPERGER’S AND SILICON VALLEY + +So far, this discussion may seem abstract, without any direct bearing on + + our daily lives. But the impact of people with mild autism and Asperger’s +may be more widespread than previously thought, especially in certain +high-tech fields. + +In the hit television series The Big Bang Theory, we follow the antics of +several young scientists, mainly nerdy physicists, in their awkward quest +for female companionship. In every episode, there is a hilarious incident +that reveals how clueless and pathetic they are in this endeavor." +"There is a tacit assumption running through the series that their +intellectual brilliance is matched only by their geekiness. And +anecdotally, people have noticed that among the high-tech gurus in +Silicon Valley, a higher percentage than normal seem to lack some social +skills. (There is a saying among women scientists who attend highly +specialized engineering universities, where the girl-to-guy ratio is +decidedly in their favor: “The odds are good, but the goods are odd.”) + +Scientists set out to investigate this suspicion. The hypothesis is that +people with Asperger’s and other mild forms of autism have mental skills +ideally suited for certain fields, like the information technology industry. +Scientists at University College London examined sixteen people who +were diagnosed with a mild form of autism and compared them with +sixteen normal individuals. Both groups were shown slides containing +random numbers and letters arranged in increasingly complex patterns." +"Their results showed that people with autism had a superior ability to +focus on the task. In fact, as the tasks became harder, the gap between +the intellectual skills of both groups began to widen, with the autistic +individuals performing significantly better than the control group. (The +test, however, also showed that these individuals were more easily +distracted by outside noises and blinking lights than the control group.) + +Dr. Nilli Lavie says, “Our study confirms our hypothesis that people +with autism have higher perceptual capacity compared to the typical +population.... People with autism are able to perceive significantly more +information than the typical adult.” + +This certainly does not prove that all people who are intellectually +brilliant have some form of Asperger’s. But it does indicate that fields +requiring the ability to focus intellectually might have a higher +proportion of people with Asperger’s. + +BRAIN SCANS OF SAVANTS" +"BRAIN SCANS OF SAVANTS + + The subject of savants has always been shrouded in hearsay and amazing +anecdotal stories. But recently, the entire field has been turned upside +down with the development of MRI and other brain scans. + +Kim Peek’s brain, for example, was unusual. MRI scans show that it +lacked the corpus callosum connecting the left and right brain, which is +probably why he could read two pages at the same time. His poor motor +skills were reflected in a deformed cerebellum, the area that controls +balance. Unfortunately, MRI scans could not reveal the exact origin of +his extraordinary abilities and photographic memory. But in general, +brain scans have shown that many suffering from acquired savant +syndrome have experienced damage to their left brain." +"In particular, interest has focused on the left anterior temporal and +orbitofrontal cortices. Some believe that perhaps all savant skills +(autistic, acquired, and Asperger’s) arise from damage to this very +specific spot in the left temporal lobe. This area can act like a “censor” +that periodically flushes out irrelevant memories. But after damage +occurs to the left hemisphere, the right hemisphere starts to take over. +The right brain is much more precise than the left brain, which often +distorts reality and confabulates. In fact, it is believed that the right +brain must work extra hard because of damage to the left brain, and +hence savant skills develop as a consequence. For example, the right +brain is much more artistic than the left brain. Normally, the left brain +restricts this talent and holds it in check. But if the left brain is injured in +a certain way, it may unleash the artistic abilities latent in the right +brain, causing an explosion of artistic talent. So the key to unleashing" +"brain, causing an explosion of artistic talent. So the key to unleashing +savant capabilities might be to dampen the left brain so that it can no +longer restrain the natural talents of the right brain. This is sometimes +referred to as “left brain injury, right brain compensation.”" +"In 1998, Dr. Bruce Miller of the University of California at San +Francisco performed a series of studies that seem to back this idea up. +He and coworkers studied five normal individuals who began to show +signs of frontotemporal dementia (FTD). As their dementia started to +progress, savant abilities gradually began to emerge. As their dementia +got worse, several of these individuals began to exhibit even more +extraordinary artistic ability, although none had shown gifts in this area + +before. Moreover, the abilities they exhibited were typical of savant +behavior. Their abilities were visual, not auditory, and their artworks, +remarkable as they were, were just copies lacking any original, abstract, +or symbolic qualities. (One patient actually got better during the study. +But her emerging savant skills were also reduced as a consequence. This +suggests a close relationship between emerging disorders of the left +temporal lobe and emerging savant skills.)" +"Dr. Miller’s analysis seemed to show that degeneration of the left +anterior temporal and orbitofrontal cortices probably decreased +inhibition of the visual systems in the right hemisphere, thereby +increasing artistic abilities. Again, damaging the left hemisphere in a +particular location forced the right hemisphere to take over and develop." +"In addition to the savants, MRI scans have also been done on people +with hyperthymestic syndrome, who also have photographic memories. +These people do not suffer from autism and mental disorders, but they +share some of their skills. In the entire United States, there are only four +documented cases of true photographic memory. One of them is Jill +Price, a school administrator in Los Angeles. She can recall precisely +what she was doing on any particular day going back decades. But she +complains that she finds it difficult to erase certain thoughts. Indeed, her +brain seems to be “stuck on autopilot.” She compares her memory to +watching the world through a split screen, in which the past and present +are constantly competing for her attention." +"Since 2000, scientists at the University of California at Irvine have +scanned her brain, and they’ve found it to be unusual. Several regions +were larger than normal, such as the caudate nuclei (which is involved +with forming habits) and the temporal lobe (which stores facts and +figures). It is theorized that these two areas work in tandem to create her +photographic memory. Her brain is therefore different from the brains of +savants who suffer an injury or damage to their left temporal lobe. The +reason is unknown, but it points to another path by which one may +obtain these fantastic mental abilities. + +CAN WE BECOME SAVANTS? + +All this raises the intriguing possibility that one might be able to + +deliberately deactivate parts of the left brain and thereby increase the +activity of the right brain, forcing it to acquire savant capabilities." +"We recall that transcranial magnetic stimulation, or TMS, allows one +to effectively silence parts of the brain. If so, then why can’t we silence +this part of the left anterior temporal and orbitofrontal cortices using the +TMS and turn on a savantlike genius at will? + +This idea has actually been tried. Dr. Allan Snyder of the University of +Sydney, Australia, made headlines a few years ago when he claimed +that, by applying the TMS to a certain part of the left brain, his subjects +could suddenly perform savantlike feats. By directing low-frequency +magnetic waves into the left hemisphere, one can in principle turn off" +"this dominant region of the brain so that the right hemisphere takes +over. Dr. Synder and his colleagues did an experiment with eleven male +volunteers. They applied the TMS to the subjects’ left frontotemporal +region while the subjects were performing tests involving reading and +drawing. This did not produce savant skills among the subjects, but two +of them had significant improvements in their ability to proofread words +and recognize duplicated words. In another experiment, Dr. R. L. Young +and his colleagues gave a battery of psychological tests to seventeen +individuals. The tests were specifically designed to test for savant skills. +(Tests of this sort analyze a person’s ability to memorize facts, +manipulate numbers and dates, create artwork, or perform music.) Five +of the subjects reported improvement in savantlike skills after treatment +with TMS." +"Dr. Michael Sweeney has observed, “When applied to the prefrontal +lobes, TMS has been shown to enhance the speed and agility of cognitive +processing. The TMS bursts are like a localized jolt of caffeine, but +nobody knows for sure how the magnets actually do their work.” These +experiments hint, but by no means prove, that silencing a part of the left +frontotemporal region could initiate some enhanced skills. These skills +are a far cry from savant abilities, and we should also be careful to point +out that other groups have looked into these experiments, and the results +have been inconclusive. More experimental work must be done, so it is +still too early to render a final judgment one way or the other. + +TMS probes are the easiest and most convenient instrument to use for +this purpose, since they can selectively silence various parts of the brain +at will without relying on brain damage and traumatic accidents. But it" +"should also be noted that TMS probes are still crude, silencing millions +of neurons at a time. Magnetic fields, unlike electrical probes, are not +precise but spread out over several centimeters. We know that the left +anterior temporal and orbitofrontal cortices are damaged in savants and +likely responsible, at least in some part, for their unique abilities, but +perhaps the specific area that must be dampened is an even smaller +subregion. So each jolt of TMS might inadvertently deactivate some of +the areas that need to remain intact in order to produce savantlike skills." +"In the future, with TMS probes we might be able to narrow down the +region of the brain involved with eliciting savant skills. Once this region +is identified, the next step would be to use highly accurate electrical +probes, like those used in deep brain stimulation, to dampen these areas +even more precisely. Then, with the push of a button, it might be +possible to use these probes to silence this tiny portion of the brain in +order to bring out savantlike skills. + + FORGETTING TO FORGET AND PHOTOGRAPHIC MEMORY + +Although savant skills may be initiated by some sort of injury to the left +brain (leading to right brain compensation), this still does not explain +precisely how the right brain can perform these miraculous feats of +memory. By what neural mechanism does photographic memory +emerge? The answer to this question may determine whether we can +become savants." +"Until recently, it was thought that photographic memory was due to +the special ability of certain brains to remember. If so, then it might be +difficult for the average person to learn these memory skills, since only +exceptional brains are capable of them. But in 2012, a new study showed +that precisely the opposite may be true. + +The key to photographic memory may not be the ability of remarkable +brains to learn; on the contrary, it may be their inability to forget. If this +is true, then perhaps photographic memory is not such a mysterious +thing after all. + +The new study was done by scientists at the Scripps Research Institute +in Florida who were working with fruit flies. They found an interesting +way in which these fruit flies learn, which may overturn a cherished idea + +of how memories are formed and forgotten. The fruit flies were exposed +to different smells and were given positive reinforcement (with food) or +negative reinforcement (with electric shocks)." +"The scientists knew that the neurotransmitter dopamine was important +to forming memories. To their surprise, they found that dopamine +actively regulates both the formation and the forgetting of new +memories. In the process of creating new memories, the dCAl receptor +was activated. By contrast, forgetting was initiated by the activation of +the DAMB receptor. + +Previously, it was thought that forgetting might be simply the +degradation of memories with time, which happens passively by itself. +This new study shows that forgetting is an active process, requiring +intervention by dopamine. + +To prove their point, they showed that by interfering with the action +of the dCAl and DAMB receptors, they could, at will, increase or +decrease the ability of fruit flies to remember and forget. A mutation in +the dCAl receptor, for example, impaired the ability of the fruit flies to +remember. A mutation in the DAMB receptor decreased their ability to +forget." +"The researchers speculate that this effect, in turn, may be partially +responsible for savants’ skills. Perhaps there is a deficiency in their +ability to forget. One of the graduate students involved in the study, +Jacob Berry, says, “Savants have a high capacity for memory. But maybe +it isn’t memory that gives them this capacity; maybe they have a bad +forgetting mechanism. This might also be the strategy for developing +drugs to promote cognition and memory—what about drugs that inhibit +forgetting as a cognitive enhancers?” + +Assuming that this result holds up in human experiments as well, it +could encourage scientists to develop new drugs and neurotransmitters +that are able to dampen the forgetting process. One might thus be able +to selectively turn on photographic memories when needed by +neutralizing the forgetting process. In this way, we wouldn’t have the +continuous overflow of extraneous, useless information, which hinders +the thinking of people with savant syndrome." +"What is also exciting is the possibility that the BRAIN project, which is +being championed by the Obama administration, might be able to +identify the specific pathways involved with acquired savant syndrome. + +Transcranial magnetic fields are still too crude to pin down the handful +of neurons that may be involved. But using nanoprobes and the latest in +scanning technologies, the BRAIN project might be able to isolate the +precise neural pathways that make possible photographic memory and +incredible computational, artistic, and musical skills. Billions of research +dollars will be channeled into identifying the specific neural pathways +involved with mental disease and other afflictions of the brain, and the +secret of savant skills may be revealed in the process. Then it might be +possible to take normal individuals and make savants out of them. This +has happened many times in the past because of random accidents. In +the future, this may become a precise medical process. Time will tell." +"So far, the methods analyzed here do not alter the nature of the brain +or the body. The hope is that through the use of magnetic fields, we will +be able to unleash the potential that already exists in our brains but is +latent. The philosophy underlying this idea is that we are all savants +waiting to happen, and it will just take some slight alteration of our +neural circuits to unleash this hidden talent. + +Yet another tactic is to directly alter the brain and the genes, using the +latest in brain science and also genetics. One promising method is to use +stem cells. + +STEM CELLS FOR THE BRAIN" +"STEM CELLS FOR THE BRAIN + + It was dogma for many decades that brain cells do not regenerate. It +seemed impossible that you could repair old, dying brain cells, or grow +new ones to boost your abilities, but all this changed in 1998. That year, +it was discovered that adult stem cells could be found in the +hippocampus, the olfactory bulb, and the caudate nucleus. In brief, stem +cells are the “mother of all cells.” Embryonic stem cells, for instance, can +readily develop into any other cell. Although each of our cells contains +all the genetic material necessary to construct a human being, only +embryonic stem cells have the ability to actually differentiate into any +type of cell in the body. + +Adult stem cells have lost that chameleon-like ability, but they can +still reproduce and replace old, dying cells. As far as memory +enhancement goes, interest has focused on adult stem cells in the" +"hippocampus. It turns out that thousands of new hippocampus cells are +born naturally each day, but most die soon afterward. However, it was +shown that rats that learned new skills retained more of their new cells. +A combination of exercise and mood-elevating chemicals can also boost +the survival rate of new hippocampus cells. It turns out that stress, on +the contrary, accelerates the death of new neurons." +"In 2007, a breakthrough occurred when scientists in Wisconsin and +Japan were able to take ordinary human skin cells, reprogram their +genes, and turn them into stem cells. The hope is that these stem cells, +either found naturally or converted using genetic engineering, can one +day be injected into the brains of Alzheimer’s patients to replace dying +cells. (These new brain cells, because they do not yet have the proper +connections, would not be integrated into the brain’s neural architecture. +This means that a person would have to relearn certain skills to +incorporate these fresh new neurons.) + +Stem cell research is naturally one of the most active areas in brain +research. “Stem cell research and regenerative medicine are in an +extremely exciting phase right now. We are gaining knowledge very fast +and many companies are being formed and are starting clinical trials in +different areas,” says Sweden’s Jonas Frisen of the Karolinska Institute. + +GENETICS OF INTELLIGENCE" +"GENETICS OF INTELLIGENCE + +In addition to stem cells, another avenue of exploration involves +isolating the genes responsible for human intelligence. Biologists note +that we are about 98.5 percent genetically identical to a chimpanzee, yet + + we live twice as long and have exploded in intellectual skills in the past +six million years. So among a handful of genes there must be the ones +responsible for giving us the human brain. Within a few years, scientists +will have a complete map of all these genetic differences, and the secret +to human longevity and enhanced intelligence may be found within this +tiny set. Scientists have focused on a few genes that possibly drove the +evolution of the human brain. + +So perhaps the clue to revealing the secret of intelligence lies in our +understanding of our apelike ancestors. This raises another question: Can +this research make possible the Planet of the Apes ?" +"In this long-running series of movies, a nuclear war destroys modern +civilization. Humanity is reduced to barbarism, but the radiation +somehow accelerates the evolution of the other primates, so that they +become the dominant species on the planet. They create an advanced +civilization, while humans are reduced to scruffy, smelly savages +roaming half naked in the forest. At best, humans become zoo animals. +The tables have turned on the humans, so the apes gawk at us outside +the bars of our cages." +"In the latest installment, The Rise of the Planet of the Apes, scientists are +looking for a cure for Alzheimer’s disease. Along the way, they stumble +on a virus that has the unintended consequence of increasing a +chimpanzee’s intelligence. Unfortunately, one of these enhanced apes is +treated cruelly when placed in a shelter for primates. Using his increased +intelligence, the ape breaks free, infects the other lab animals with the +virus to raise their intelligence, and then frees all of them from their +cages. Soon a caravan of shouting, intelligent apes runs amok on the +Golden Gate Bridge, completely overwhelming local and state police. +After a spectacular, harrowing confrontation with the authorities, the +movie ends with the apes peacefully finding refuge in a redwood forest +north of the bridge." +"Is such a scenario realistic? In the short term, no, but it can’t be ruled +out in the future, since scientists in the coming years should be able to +catalog all the genetic changes that created Homo sapiens. But many +more mysteries have to be solved before we have intelligent apes. + +One scientist who has been fascinated not by science fiction, but by +the genetics of what makes us “human,” is Dr. Katherine Pollard, an +expert in a field called “bioinformatics,” which barely existed a decade +ago. In this field of biology, instead of cutting open animals to +understand how they are put together, researchers use the vast power of +computers to mathematically analyze the genes in animals’ bodies. She +has been at the forefront of finding the genes that define the essence of +what separates us from the apes. Back in 2003, as a freshly minted Ph.D. + + from the University of California at Berkeley, she got her chance." +"from the University of California at Berkeley, she got her chance. + +“I jumped at the opportunity to join the international team that was +identifying the sequence of DNA bases, or ‘letters,’ in the genome of the +common chimpanzee,” she recalled. Her goal was clear. She knew that +only fifteen million base pairs, or “letters,” that make up our genome + +(out of three billion base pairs) separate us from the chimps, our closest +genetic neighbor. (Each “letter” in our genetic code refers to a nucleic +acid, of which there are four, labeled A,T,C, and G. So our genome +consists of three billion letters, arranged like ATTCCAGGG....) + +“I was determined to find them,” she wrote." +"“I was determined to find them,” she wrote. + +Isolating these genes could have enormous implications for our future. +Once we know the genes that gave rise to Homo sapiens, it becomes +possible to determine how humans evolved. The secret of intelligence +might lie in these genes. It might even be possible to accelerate the path +taken by evolution and even enhance our intelligence. But even fifteen +million base pairs is a huge number to analyze. How can you find a +handful of genetic needles out of this genetic haystack?" +"Dr. Pollard knew that most of our genome is made of “junk DNA” that +does not contain any genes and was largely unaffected by evolution. This +junk DNA slowly mutates at a known rate (roughly 1 percent of it +changes over four million years). Since we differ from the chimps in our +DNA by 1.5 percent, this means that we probably separated from the +chimpanzees about six million years ago. Hence there is a “molecular +clock” in each of our cells. And since evolution accelerates this mutation +rate, analyzing where this acceleration took place allows you to tell +which genes are driving evolution. + +Dr. Pollard reasoned that if she could write a computer program that +could find where most of these accelerated changes are located in our +genome, she could isolate precisely the genes that gave birth to Homo +sapiens. After months of hard work and debugging, she finally placed her +program into the giant computers located at the University of California +at Santa Cruz. Anxiously she awaited the results." +"When the computer printout finally arrived, it showed what she was +looking for: there are 201 regions of our genome showing accelerated +change. But the first one on her list caught her attention. + +“With my mentor David Haussler leaning over my shoulder, I looked +at the top hit, a stretch of 118 bases that together became known as +human accelerated region 1 (HAR1),” she recalled. + + She was ecstatic. Bingo! + +“We had hit the jackpot,” she would write. It was a dream come true. + +She was staring at an area of our genome containing only 118 base +pairs, with the largest divergence of mutations separating us from the + +apes. Of these base pairs, only eighteen mutations were altered since we +became human. Her remarkable discovery showed that a small handful +of mutations could be responsible for raising us from the swamp of our +genetic past." +"Next she and her colleagues tried to decipher the precise nature of this +mysterious cluster called HAR1. They found that HAR1 was remarkably +stable across millions of years of evolution. Primates separated from +chickens about three hundred million years ago, yet only two base pairs +differ between chimps and chickens. So HAR1 was virtually unchanged +for several hundred million years, with only two changes, in the letters G +and C. Yet in just six million years, HAR1 mutated eighteen times, +representing a huge acceleration in our evolution." +"But what was more intriguing was the role HAR1 played in controlling +the overall layout of the cerebral cortex, which is famous for its wrinkled +appearance. A defect in the HAR1 region causes a disorder called +“lissencephaly,” or “smooth brain,” causing the cortex to fold +incorrectly. (Defects in this region are also linked to schizophrenia.) +Besides the large size of our cerebral cortex, one of its main +characteristics is that it is highly wrinkled and convoluted, vastly +increasing its surface area and hence its computational power. Dr. +Pollard’s work showed that changing just eighteen letters in our genome +was partially responsible for one of the major, defining genetic changes +in human history, vastly increasing our intelligence. (Recall that the +brain of Carl Friedrich Gauss, one of the greatest mathematicians in +history, was preserved after his death and showed unusual wrinkling.)" +"Dr. Pollard’s list went even further and identified a few hundred other +areas that also showed accelerated change, some of which were already +known. FOX2, for example, is crucial for the development of speech, +another key characteristic of humans. (Individuals with a defective FOX2 +gene have difficulty making the facial movements necessary for speech.) +Another region called HAR2 gives our fingers the dexterity required to +manipulate delicate tools. + +Furthermore, since the genome of the Neanderthal has been +sequenced, it is possible to compare our genetic makeup with a species +even closer to us than the chimpanzees. (When analyzing the FOX2 gene +in Neanderthals, scientists found that we shared the same gene with + + them. This means that there is a possibility that the Neanderthal could + +vocalize and create speech, as we do.)" +"vocalize and create speech, as we do.) + +Another crucial gene is called ASPM, which is thought to be +responsible for the explosive growth of our brain capacity. Some +scientists believe that this and other genes may reveal why humans +became intelligent but the apes did not. (People with a defective version +of the ASPM gene often suffer from microcephaly, a severe form of +mental retardation, because they have a tiny skull, about the size of one +of our ancestors, Australopithecus.)" +"Scientists have tracked the number of mutations within the ASPM +gene and found that it has mutated about fifteen times in the last five to +six million years, since we separated from the chimpanzee. More recent +mutations in these genes seem to be correlated with milestones in our +evolution. For example, one mutation occurred over one hundred +thousand years ago, when modern humans emerged in Africa, +indistinguishable in appearance from us. And the last mutation was +5,800 years ago, which coincides with the introduction of the written +language and agriculture. + +Because these mutations coincide with periods of rapid growth in +intellect, it is tantalizing to speculate that ASPM is among the handful of +genes responsible for our increased intelligence. If this is true, then +perhaps we can determine whether these genes are still active today, and +whether they will continue to shape human evolution into the future." +"All this research raises a question: Can manipulating a handful of +genes increase our intelligence? + +Quite possibly. + +Scientists are rapidly determining the precise mechanism by which +these genes gave rise to intelligence. In particular, genetic regions and +genes like HAR1 and ASPM could help solve a mystery concerning the +brain. If there are roughly twenty-three thousand genes in your genome, +then how can they possibly control the connections linking one hundred +billion neurons, containing a quadrillion total connections (1 with fifteen +zeros after it)? It seems mathematically impossible. The human genome +is about a trillion times too small to code for all our neural connections. +So our very existence seems to be a mathematical impossibility. + +The answer may be that nature takes numerous shortcuts in creating +the brain. First, many neurons are connected randomly, so that a +detailed blueprint is not necessary, which means that these randomly" +"connected regions organize themselves after a baby is born and starts to +interact with the environment. + +And second, nature also uses modules that repeat themselves over and +over again. Once nature discovers something useful, she often repeats it. +This may explain why only a handful of genetic changes are responsible +for most of our explosive growth in intelligence in the last six million +years. + +Size does matter in this case, then. If we tweak the ASPM and a few +other genes, the brain might become larger and more complex, thereby +making it possible to increase our intelligence. (Increasing our brain size +is not sufficient to do this, since how the brain is organized is also +crucially important. But increasing the gray matter of our brain is a +necessary precondition to increasing our intelligence.) + +APES, GENES, AND GENIUS" +"APES, GENES, AND GENIUS + +Dr. Pollard’s research focused on areas of our genome that we share with +the chimpanzees but that are mutated. It is also possible that there are +areas in our genome found only in humans, independent of the apes. +One such gene was discovered recently, in November 2012. Scientists, +led by a team at the University of Edinburgh, isolated the RIM-941 gene, +which is the only gene ever discovered that is found strictly in Homo +sapiens and not in other primates. Also, geneticists can show that the +gene emerged between one and six million years ago (after the time +when humans and chimpanzees split about six million years ago)." +"Unfortunately, this discovery also set off a huge firestorm in science +newsletters and blogs as misleading headlines blared across the Internet. +Breathless articles appeared claiming that scientists had found a single +gene that could, in principle, make chimpanzees intelligent. The essence +of “humanness” had finally been isolated at the genetic level, the +headlines shouted. + +Reputable scientists soon stepped in and tried to calm things down. In +all likelihood, a series of genes, acting together in complex ways, is +responsible for human intelligence. No single gene can make a chimp +suddenly have human intelligence, they said. + +Although these headlines were highly exaggerated, they did raise a + +serious question: How realistic is Planet of the Apes ?" +"There are a series of complications. If the HAR1 and ASPM genes are +tweaked so that the size and structure of the chimp brain suddenly +expand, then a series of other genes would have to be modified as well. +First, you would have to strengthen the chimp’s neck muscles and +increase its body size to support the larger head. But a large brain would +be useless unless it could control fingers capable of exploiting tools. So +the HAR2 gene would also have to be altered to increase their dexterity. +But since chimps often walk on their hands, another gene would have to +be altered so that the backbone would straighten out and an upright +posture would free up the hands. Intelligence is also useless unless +chimps can communicate with other members of the species. So the +FOX2 gene would also have to be mutated so that humanlike speech +would become possible. And lastly, if you want to create a species of +intelligent apes, you would have to modify the birth canal, since it is not" +"intelligent apes, you would have to modify the birth canal, since it is not +large enough to accommodate the larger skull. You could either perform +caesarians to cut the fetus out or genetically alter the birth canal of the +chimps to accommodate the larger brain." +"After all these necessary genetic adjustments, we are left with a +creature that would look very much like us. In other words, it may be +anatomically impossible to create intelligent apes, as in the movies, +without their also mutating into something closely resembling human +beings. + +Clearly, creating intelligent apes is no simple matter, then. The +intelligent apes we see in Hollywood movies are actually monkey suits +with humans inside, or are computer-generated graphics, so all these +issues are conveniently brushed under the rug. But if scientists could +seriously use gene therapy to create intelligent apes, then they might +closely resemble us, with hands that can use tools, vocal cords that can +create speech, backbones that can support an upright posture, and large +neck muscles to support large heads, as we have." +"All this raises ethical issues as well. Although society may allow +genetic studies of apes, it may not tolerate the manipulation of +intelligent creatures that can feel pain and distress. These creatures, after +all, would be intelligent and articulate enough to complain about their +situation and their fate, and their views would be heard in society. + +Not surprisingly, this area of bioethics is so new that it is totally + +unexplored. The technology is not yet ready, but in the coming decades, +as we identify all the genes and their functions that separate us from the +apes, the treatment of these enhanced animals could become a key +question." +"We can see, therefore, that it is only a matter of time before all the +tiny genetic differences between us and the chimpanzees are carefully +sequenced, analyzed, and interpreted. But this still does not explain a +deeper question: What were the evolutionary forces that gave us this +genetic heritage after we separated from the apes? Why did genes like +ASPM, HAR1, and FOX2 develop in the first place? In other words, +genetics gives us the ability to understand how we became intelligent, +but it does not explain why this happened. + +If we can understand this issue, it might provide clues as to how we +might evolve in the future. This takes us to the heart of the ongoing +debate: What is the origin of intelligence? + +THE ORIGIN OF INTELLIGENCE + +Many theories have been proposed as to why humans developed greater +intelligence, going all the way back to Charles Darwin." +"According to one theory, the evolution of the human brain probably +took place in stages, with the earliest phase initiated by climate change +in Africa. As the weather cooled, the forests began to recede, forcing our +ancestors onto the open plains and savannahs, where they were exposed +to predators and the elements. To survive in this new, hostile +environment, they were forced to hunt and walk upright, which freed up +their hands and opposable thumbs to use tools. This in turn put a +premium on a larger brain to coordinate tool making. According to this +theory, ancient man did not simply make tools—“tools made man.”" +"Our ancestors did not suddenly pick up tools and become intelligent. It +was the other way around. Those humans who picked up tools could +survive in the grasslands, while those who did not gradually died off. +The humans who then survived and thrived in the grasslands were those +who, through mutations, became increasingly adept at tool making, +which required an increasingly larger brain. + +Another theory places a premium on our social, collective nature." +"Another theory places a premium on our social, collective nature. + +Humans can easily coordinate the behavior of over a hundred other +individuals involved in hunting, farming, warring, and building, groups +that are much larger than those found in other primates, which gave +humans an advantage over other animals. It takes a larger brain, +according to this theory, to be able to assess and control the behavior of +so many individuals. (The flip side of this theory is that it took a larger +brain to scheme, plot, deceive, and manipulate other intelligent beings +in your tribe. Individuals who could understand the motives of others + + and then exploit them would have an advantage over those who could +not. This is the Machiavellian theory of intelligence.)" +"Another theory maintains that the development of language, which +came later, helped accelerate the rise of intelligence. With language +comes abstract thought and the ability to plan, organize society, create +maps, etc. Humans have an extensive vocabulary unmatched by any +other animal, with words numbering in the tens of thousands for an +average person. With language, humans could coordinate and focus the +activities of scores of individuals, as well as manipulate abstract +concepts and ideas. Language meant you could manage teams of people +on a hunt, which is a great advantage when pursuing the woolly +mammoth. It meant you could tell others where game was plentiful or +where danger lurked." +"Yet another theory is “sexual selection,” the idea that females prefer to +mate with intelligent males. In the animal kingdom, such as in a wolf +pack, the alpha male holds the pack together by brute force. Any +challenger to the alpha male has to be soundly beaten back by tooth and +claw. But millions of years ago, as humans became gradually more +intelligent, strength alone could not keep the tribe together. Anyone +with cunning and intelligence could ambush, lie or cheat, or form +factions within the tribe to take down the alpha male. Hence the new +generation of alpha males would not necessarily be the strongest. Over +time, the leader would become the most intelligent and cunning. This is +probably the reason why females choose smart males (not necessarily +nerdy smart, but “quarterback smart”). Sexual selection in turn +accelerated our evolution to become intelligent. So in this case the +engine that drove the expansion of our brain would be females who" +"engine that drove the expansion of our brain would be females who +chose men who could strategize, become leaders of the tribe, and outwit +other males, which requires a large brain." +"These are just a few of the theories about the origin of intelligence, +and each has its pros and cons. The common theme seems to be the +ability to simulate the future. For example, the purpose of the leader is +to choose the correct path for the tribe in the future. This means any +leader has to understand the intentions of others in order to plan +strategy for the future. Hence simulating the future was perhaps one of +the driving forces behind the evolution of our large brain and +intelligence. And the person who can best simulate the future is the one +who can plot, scheme, read the minds of many of his fellow tribesmen, +and win the arms race with his fellow man. + +Similarly, language allows you to simulate the future. Animals possess +a rudimentary language, but it is mainly in the present tense. Their +language may warn them of an immediate threat, such as a predator +hiding among the trees. However, animal language apparently has no" +"future or past tense. Animals do not conjugate their verbs. So perhaps +the ability to express the past and future tense was a key breakthrough +in the development of intelligence. + +Dr. Daniel Gilbert, a psychologist at Harvard, writes, “For the first few +hundred million years after their initial appearance on our planet, our +brains were stuck in the permanent present, and most brains still are +today. But not yours and not mine, because two or three million years +ago our ancestors began a great escape from the here and now....” + +THE FUTURE OF EVOLUTION + +So far, we have seen that there are intriguing results indicating that one +can increase one’s memory and intelligence, largely by making the brain +more efficient and maximizing its natural capacity. A variety of methods +are being studied, such as certain drugs, genes, or devices (TES, for +example) that might increase the capabilities of our neurons." +"So the concept of altering the brain size and capacity of the apes is a +distinct, though difficult, possibility. Gene therapy on this scale is still +many decades away. But this raises another difficult question: How far +can this go? Can one extend the intelligence of an organism indefinitely? +Or is there a limit to brain modification imposed by the laws of physics? + +Surprisingly, the answer is yes. The laws of physics put an upper limit + +to what can be done with genetic modification of the human brain, +given certain restraints. To see this limit, it is instructive to first examine +whether evolution is still increasing human intelligence, and then what +can be done to accelerate this natural process." +"In popular culture, there is the notion that evolution will give us big +brains and small, hairless bodies in the future. Likewise, aliens from +space, because they are supposed to possess a superior level of +intelligence, are often portrayed in this fashion. Go to any novelty shop +and you will see the same extraterrestrial face, with big bug eyes, a huge +head, and green skin. + +Actually, there are indications that gross human evolution (i.e., our +basic body shape and intelligence) has largely come to a halt. There are +several factors supporting this. First of all, since we are bipedal +mammals who walk upright, there are limitations to the maximum size +of an infant’s skull that can pass through the birth canal. Second, the rise +of modern technology has removed many of the harsh evolutionary +pressures faced by our ancestors." +"However, evolution on a genetic and molecular basis continues +unabated. Although it’s difficult to see with the naked eye, there is +evidence that human biochemistry has changed to adjust to +environmental challenges, such as combating malaria in tropical areas. +Also, humans recently evolved enzymes to digest lactose sugar as we +learned to domesticate cows and drink milk. Mutations have occurred as +humans adjusted to a diet created by the agricultural revolution. +Moreover, people still choose to mate with others who are healthy and +fit, and so evolution continues to eliminate unsuitable genes at this level. +None of these mutations, however, has changed our basic body plan or +increased our brain size. (Modern technology is also influencing our +evolution to some degree. For example, there is no longer any selection +pressure on nearsighted people, since anyone today can be outfitted with +glasses or contact lenses.) + +PHYSICS OF THE BRAIN" +"PHYSICS OF THE BRAIN + +So from an evolutionary and biological point of view, evolution is no +longer selecting for more intelligent people, at least not as rapidly as it + +did thousands of years ago. + +There are also indications from the laws of physics that we have +reached the maximum natural limit of intelligence, so that any +enhancement of our intelligence would have to come from external +means. Physicists who have studied the neurology of the brain conclude +that there are trade-offs preventing us from getting much smarter. Every +time we envision a brain that is larger, or denser, or more complex, we +bump up against these negative trade-offs." +"The first principle of physics that we can apply to the brain is the +conservation of matter and energy; that is, the law stating that the total +amount of matter and energy in a system remains constant. In particular, +in order to carry out its incredible feats of mental gymnastics, the brain +has to conserve energy, and hence it takes many shortcuts. As we saw in +Chapter 1, what we see with our eyes is actually cobbled together using +energy-saving tricks. It would take too much time and energy for a +thoughtful analysis of every crisis, so the brain saves energy by making +snap judgments in the form of emotions. Forgetting is an alternative way +of saving energy. The conscious brain has access to only a tiny portion of +the memories that have an impact on the brain. + +So the question is: Would increased brain size or density of neurons +give us more intelligence?" +"So the question is: Would increased brain size or density of neurons +give us more intelligence? + + Probably not. “Cortical gray matter neurons are working with axons +that are pretty close to the physical limit,” says Dr. Simon Laughlin of +Cambridge University. There are several ways in which one can increase +the intelligence of the brain using the laws of physics, but each has its +own problems: + +• One can increase brain size and extend the length of neurons. The +problem here is that the brain now consumes more energy. This +generates more heat in the process, which is detrimental to our +survival. If the brain uses up more energy, it gets hotter, and tissue +damage results if the body temperature becomes too high. (The +chemical reactions of the human body and our metabolism require +temperatures to be in a precise range.) Also, longer neurons means +that it takes longer for signals to go across the brain, which slows +down the thinking process." +"• One can pack more neurons into the same space by making them + +thinner. But if neurons become thinner and thinner, the complex +chemical/electrical reactions that must take place inside the axons +fail, and eventually they begin to misfire more easily. Douglas Fox, +writing in Scientific American, says, “You might call it the mother of +all limitations: the proteins that neurons use to generate electrical +pulses, called ion channels, are inherently unstable.” + +• One can increase the speed of the signal by making the neurons +thicker. But this also increases energy consumption and generates +more heat. It also increases the size of the brain, which increases the +time it takes for the signals to reach their destination. + +• One can add more connections between neurons. But this again +increases energy consumption and heat generation, making the +brain larger and slower in the process." +"So each time we tinker with the brain, we are checkmated. The laws +of physics seem to indicate that we have maxed out the intelligence that +we humans can attain in this way. Unless we can suddenly increase the +size of our skulls or the very nature of neurons in our brains, it seems we +are at the maximum level of intelligence. If we are to increase our +intelligence, it has to be done by making our brains more efficient (via +drugs, genes, and possibly TES-type machines). + +PARTING THOUGHTS + +In summary, it may be possible in the coming decades to use a" +"PARTING THOUGHTS + +In summary, it may be possible in the coming decades to use a + + combination of gene therapy, drugs, and magnetic devices to increase +our intelligence. There are several avenues of exploration that are +revealing the secrets of intelligence and how it may be modified or +enhanced. But what would it do to society, though, if we could enhance +our intelligence and get a “brain boost”? Ethicists have seriously +contemplated this question, since the basic science is growing so rapidly. +The big fear is that society may bifurcate, with only the rich and +powerful having access to this technology, which they could use to +further solidify their exalted position in society. Meanwhile, the poor +won’t have access to additional brain power, making it more difficult to +move up in society." +"This is certainly a valid concern, but it flies in the face of the history +of technology. Many of the technologies of the past were indeed initially +the province of the rich and powerful, but eventually mass production, +competition, better transportation, and improvements in technology +drove down the costs, so the average person could afford them. (For +example, we take for granted that we eat foods for breakfast that the +king of England could not have procured a century ago. Technology has +made it possible to purchase delicacies from around the world at any +supermarket that would be the envy of the aristocrats of the Victorian +era.) So if it becomes possible to increase our intelligence, the price of +this technology will gradually fall. Technology is never the monopoly of +the privileged rich. Sooner or later ingenuity, hard work, and simple +market forces will drive down its cost." +"There is also the fear that the human race will split into those who +want their intelligence to be boosted and those who prefer to remain the +same, resulting in the nightmare of having a class of super-intelligent +brahmins lord over the masses of the less gifted. + +But again, perhaps the fear of boosting intelligence has been +exaggerated. The average person has absolutely no interest in being able +to solve the complex tensor equations for a black hole. The average +person sees nothing to gain by mastering the mathematics of +hyperspatial dimensions or the physics of the quantum theory. On the +contrary, the average person may find such activities rather boring and +useless. So most of us are not going to become mathematical geniuses if +given the opportunity, because it is not in our character, and we see +nothing to gain from it." +"Keep in mind that society already has a class of accomplished +mathematicians and physicists, and they are paid significantly less than +ordinary businessmen and wield much less power than average +politicians. Being super smart does not guarantee financial success in +life. In fact, being super smart may actually pigeonhole you in the lower +rungs of a society that values athletes, movie stars, comedians, and + + entertainers more. + +No one ever got rich doing relativity. + +Also, a lot depends on precisely which traits are enhanced. There are +other forms of intelligence besides using mathematics. (Some argue that +intelligence must include artistic genius as well. In this case, one can + +conceivably use this talent to make a comfortable living.)" +"conceivably use this talent to make a comfortable living.) + +Anxious parents of high school children may want to boost the IQ of +their kids as they prepare for standardized exams. But IQ, as we have +seen, does not necessarily correspond to success in life. Likewise, people +may want to enhance their memory, but, as we have seen with savants, +having a photographic memory can be a blessing as well as a curse. And +in both cases, enhancement is unlikely to contribute to a society splitting +in two. + +Society as a whole, however, may benefit from this technology. +Workers with an enhanced intelligence would be better prepared to face +an ever-changing job market. Retraining workers for the jobs of the +future would be less of a drain on society. Furthermore, the public will +be able to make informed decisions about major technological issues of +the future (e.g., climate change, nuclear energy, space exploration) +because they will grasp these complex issues better." +"Also, this technology may help even out the playing field. Children +today who go to exclusive private schools and have personal tutors are +better prepared for the job market because they have more opportunities +to master difficult materials. But if everyone has had their intelligence +enhanced, the fault lines within society will be evened out. Then how far +someone goes in life would be more related to their drive, ambition, +imagination, and resourcefulness rather than to being born with a silver +spoon in their mouth. + +In addition, raising our intelligence may help speed up technological +innovation. Increased intelligence would mean a greater ability to +simulate the future, which would be invaluable in making scientific +discoveries. Often, science stagnates in certain areas because of a lack of +fresh new ideas to stimulate new avenues of research. Having an ability +to simulate different possible futures would vastly increase the rate of +scientific breakthroughs." +"These scientific discoveries, in turn, could generate new industries, +which could enrich all of society, creating new markets, new jobs, and +new opportunities. History is full of technological breakthroughs +creating entirely new industries that benefited not just the few, but all of + + society (think of the transistor and the laser, which today form the +foundation of the world economy). + +However, in science fiction, there is the recurring theme of the super + +criminal, who uses his superior brain power to embark on a crime spree +and thwart the superhero. Every Superman has his Lex Luthor, every +Spider-Man has his Green Goblin. Although it is certainly possible that a +criminal mind will use a brain booster to create super weapons and plan +the crime of the century, realize that members of the police force can +also have their intelligence boosted to outwit the evil mastermind. So +super criminals are dangerous only if they are the only ones in +possession of enhanced intelligence." +"So far, we have examined the possibility that we can enhance or alter +our mental capabilities via telepathy, telekinesis, uploading memories, +or brain boosts. Such enhancement basically means modifying and +augmenting the mental capabilities of our consciousness. This tacitly +assumes that our normal consciousness is the only one, but I’d like to +explore whether there are different forms of consciousness. If so, there +could be other ways of thinking that lead to totally different outcomes +and consequences. Within our own thoughts, there are altered states of +consciousness, such as dreams, drug-induced hallucinations, and mental +illness. There is also nonhuman consciousness, the consciousness of +robots, and even that of aliens from outer space. We have to give up the +chauvinistic notion that our human consciousness is the only one. There +is more than one way to create a model of our world, and more than one +way to simulate its future." +"Dreams, for example, are one of the most ancient forms of +consciousness and were studied by the ancients, yet very little progress +has been made in understanding them until recently. Perhaps dreams are +not silly, random events spliced together by the sleeping brain but +phenomena that may give insight into the meaning of consciousness. +Dreams may be a key to understanding altered states of consciousness. + +BOOK III ALTEHED CONSCIOUSNESS + +The future belongs to those who believe in the beauty of their +dreams. + +—ELEANOR ROOSEVELT + + 7 IN YOUR DREAMS + +Dreams can determine destiny." +"—ELEANOR ROOSEVELT + + 7 IN YOUR DREAMS + +Dreams can determine destiny. + +Perhaps the most famous dream in antiquity took place in the year +A.D. 312, when the Roman emperor Constantine engaged in one of the +greatest battles of his life. Faced with a rival army twice the size of his +own, he realized that he probably would die in battle the next day. But +in a dream he had that night, an angel appeared before him bearing the +image of a cross, uttering the fateful words “By this symbol, you shall +conquer.” Immediately he ordered the shields of his troops adorned with +the symbol of the cross." +"History records that he emerged triumphant the next day, cementing +his hold on the Roman Empire. He vowed to repay the blood debt to this +relatively obscure religion, Christianity, that had been persecuted for +centuries by previous Roman emperors and whose adherents were +regularly fed to the lions in the Colosseum. He signed laws that would +eventually pave the way for it to become an official religion of one of +the greatest empires in the world." +"For thousands of years, kings and queens, as well as beggars and +thieves, have all wondered about dreams. The ancients considered +dreams to be omens about the future, so there have been countless +attempts throughout history to interpret them. The Bible records in +Genesis 41 the rise of Joseph, who was able to correctly interpret the +dreams of the Pharaoh of Egypt thousands of years ago. When the +Pharaoh dreamed about seven fat cows, followed by seven lean cows, he +was so disturbed by the imagery that he asked scribes and mystics +throughout the kingdom to find its meaning. All failed to give a +convincing explanation, until Joseph finally interpreted the dream to +mean that Egypt would have seven years of good harvests, followed by +seven years of drought and famine. So, said Joseph, Egypt must begin +stockpiling grain and supplies now, in preparation for the coming years +of want and desperation. When this came to pass, Joseph was considered + +to be a prophet." +"to be a prophet. + +Dreams have long been associated with prophesy, but in more recent +times they’ve also been known to stimulate scientific discovery. The idea +that neurotransmitters could facilitate the movement of information past +a synapse, which forms the foundation of neuroscience, came to +pharmacologist Otto Loewi in a dream. Similarly, in 1865, August +Kekule had a dream about benzene, in which the bonds of carbon atoms +formed a chain that eventually wrapped around and finally formed a + + circle, just like a snake biting its tail. This dream would unlock the +atomic structure of the benzene molecule. He concluded, “Let us learn to +dream!”" +"Dreams have also been interpreted as a window onto our true +thoughts and intentions. The great Renaissance writer and essayist +Michel de Montaigne once wrote, “I believe it to be true that dreams are +the true interpretations of our inclinations, but there is art required to +sort and understand them.” More recently, Sigmund Freud proposed a +theory to explain the origin of dreams. In his signature work, The +Interpretation of Dreams, he claimed that they were manifestations of our +subconscious desires, which were often repressed by the waking mind +but which run wild every night. Dreams were not just the random +figments of our overheated imaginations but could actually uncover +deep secrets and truths about ourselves. “Dreams are the royal road to +the unconscious,” he wrote. Since then, people have amassed huge +encyclopedias that claim to reveal the hidden meaning behind every +disturbing image in terms of Freudian theory." +"Hollywood takes advantage of our continuing fascination with dreams. +A favorite scene in many movies is when the hero experiences a +terrifying dream sequence and then suddenly wakes up from the +nightmare in a cold sweat. In the blockbuster movie Inception, Leonardo +DiCaprio plays a petty thief who steals intimate secrets from the most +unlikely of all places, people’s dreams. With a new invention, he is able +to enter people’s dreams and deceive them into giving up their financial +secrets. Corporations spend millions of dollars protecting industrial +secrets and patents. Billionaires jealously guard their wealth using +elaborate codes. His job is to steal them. The plot quickly escalates as +the characters enter dreams in which a person falls asleep and dreams +again. So these criminals descend deeper and deeper into multiple layers + +of the subconscious." +"of the subconscious. + +But although dreams have always haunted and mystified us, only in +the last decade or so have scientists been able to peel away the mysteries +of dreams. In fact, scientists can now do something once considered +impossible: they are able to take rough photographs and videotapes of +dreams with MRI machines. One day, you may be able to view a video of +the dream you had the previous night and gain insight into your own +subconscious mind. With proper training, you might be able to +consciously control the nature of your dreams. And perhaps, like +DiCaprio’s character, with advanced technology you might even be able +to enter someone else’s dream. + +THE NATURE OF DREAMS" +"THE NATURE OF DREAMS + + As mysterious as they are, dreams are not a superfluous luxury, the +useless ruminations of the idle brain. Dreams, in fact, are essential for +survival. Using brain scans, it is possible to show that certain animals +exhibit dreamlike brain activity. If deprived of dreams, these animals +would often die faster than they would by starvation, because such +deprivation severely disrupts their metabolism. Unfortunately, science +does not know exactly why this is the case. + +Dreaming is an essential feature of our sleep cycle as well. We spend +roughly two hours a night dreaming when we sleep, with each dream +lasting five to twenty minutes. In fact, we spend about six years +dreaming during an average lifetime." +"Dreams are also universal across the human race. Looking across +different cultures, scientists find common themes in dreams. Fifty +thousand dreams were recorded over a forty-year time period by +psychology professor Calvin Hall. He followed this up with one thousand +dream reports from college students. Not surprisingly, he found that +most people dreamed of the same things, such as personal experiences +from the previous days or week. (However, animals apparently dream +differently than we do. In the dolphin, for example, only one hemisphere +at a time sleeps in order to prevent drowning, because they are air- +breathing mammals, not fish. So if they dream, it is probably in only one +hemisphere at a time.)" +"The brain, as we have seen, is not a digital computer, but rather a +neural network of some sort that constantly rewires itself after learning +new tasks. Scientists who work with neural networks noticed something +interesting, though. Often these systems would become saturated after +learning too much, and instead of processing more information they +would enter a “dream” state, whereby random memories would +sometimes drift and join together as the neural networks tried to digest +all the new material. Dreams, then, might reflect “house cleaning,” in +which the brain tries to organize its memories in a more coherent way. +(If this is true, then possibly all neural networks, including all organisms +that can learn, might enter a dream state in order to sort out their +memories. So dreams probably serve a purpose. Some scientists have +speculated that this might imply that robots that learn from experience +might also eventually dream as well.)" +"Neurological studies seem to back up this conclusion. Studies have +shown that retaining memories can be improved by getting sufficient +sleep between the time of activity and a test. Neuroimaging shows that +the areas of the brain that are activated during sleep are the same as +those involved in learning a new task. Dreaming is perhaps useful in + + consolidating this new information. + +Also, some dreams can incorporate events that happened a few hours +earlier, just before sleep. But dreams mostly incorporate memories that +are a few days old. For example, experiments have shown that if you put +rose-colored glasses on a person, it takes a few days before the dreams +become rose-colored as well. + +BRAIN SCANS OF DREAMS" +"BRAIN SCANS OF DREAMS + +Brain scans are now unveiling some of the mystery of dreams. Normally +EEG scans show that the brain is emitting steady electromagnetic waves +while we are awake. However, as we gradually fall asleep, our EEG +signals begin to change frequency. When we finally dream, waves of +electrical energy emanate from the brain stem that surge upward, rising +into the cortical areas of the brain, especially the visual cortex. This +confirms that visual images are an important component of dreams. +Finally, we enter a dream state, and our brain waves are typified by + +rapid eye movements (REM). (Since some mammals also enter REM +sleep, we can infer that they might dream as well.)" +"While the visual areas of the brain are active, other areas involved +with smell, taste, and touch are largely shut down. Almost all the images +and sensations processed by the body are self-generated, originating +from the electromagnetic vibrations from our brain stem, not from +external stimuli. The body is largely isolated from the outside world. +Also, when we dream, we are more or less paralyzed. (Perhaps this +paralysis is to prevent us from physically acting out our dreams, which +could be disastrous. About 6 percent of people suffer from “sleep +paralysis” disorder, in which they wake up from a dream still paralyzed. +Often these individuals wake up frightened and believing that there are +creatures pinning down their chest, arms, and legs. There are paintings +from the Victorian era of women waking up with a terrifying goblin +sitting on their chest glaring down at them. Some psychologists believe +that sleep paralysis could explain the origin of the alien abduction +syndrome.)" +"The hippocampus is active when we dream, suggesting that dreams +draw upon our storehouse of memories. The amygdala and anterior +cingulate are also active, meaning that dreams can be highly emotional, +often involving fear. + +But more revealing are the areas of the brain that are shut down, +including the dorsolateral prefrontal cortex (which is the command + + center of the brain), the orbitofrontal cortex (which can act like a censor +or fact-checker), and the temporoparietal region (which processes +sensory motor signals and spatial awareness)." +"When the dorsolateral prefrontal cortex is shut down, we can’t count +on the rational, planning center of the brain. Instead, we drift aimlessly +in our dreams, with the visual center giving us images without rational +control. The orbitofrontal cortex, or the fact-checker, is also inactive. +Hence dreams are allowed to blissfully evolve without any constraints +from the laws of physics or common sense. And the temporoparietal +lobe, which helps coordinate our sense of where we are located using +signals from our eyes and inner ear, is also shut down, which may +explain our out-of-body experiences while we dream. + +As we have emphasized, human consciousness mainly represents the +brain constantly creating models of the outside world and simulating + +them into the future. If so, then dreams represent an alternate way in +which the future is simulated, one in which the laws of nature and social +interactions are temporarily suspended. + +HOW DO WE DREAM?" +"HOW DO WE DREAM? + +But that leaves open this question: What generates our dreams? One of +the world’s authorities on dreams is Dr. Allan Hobson, a psychiatrist at +Harvard Medical School. He has devoted decades of his life to unveiling +the secrets of dreams. He claims that dreams, especially REM sleep, can +be studied at the neurological level, and that dreams arise when the +brain tries to make sense of the largely random signals emanating from +the brain stem. + +When I interviewed him, he told me that after many decades of +cataloging dreams, he found five basic characteristics: + +1. Intense emotions—this is due to the activation of the amygdala, +causing emotions such as fear. + +2. Illogical content—dreams can rapidly shift from one scene to +another, in defiance of logic. + +3. Apparent sensory impressions—dreams give us false sensations that +are internally generated. + +4. Uncritical acceptance of dream events—we uncritically accept the +illogical nature of the dream." +"5. Difficulty in being remembered—dreams are soon forgotten, within +minutes of waking up. + +Dr. Hobson (with Dr. Robert McCarley) made history by proposing the +first serious challenge to Freud’s theory of dreams, called the “activation +synthesis theory.” In 1977, they proposed the idea that dreams originate +from random neural firings in the brain stem, which travel up to the +cortex, which then tries to make sense of these random signals. + +The key to dreams lies in nodes found in the brain stem, the oldest +part of the brain, which squirts out special chemicals, called adrenergics, +that keep us alert. As we go to sleep, the brain stem activates another + +system, the cholinergic, which emits chemicals that put us in a dream +state." +"system, the cholinergic, which emits chemicals that put us in a dream +state. + +As we dream, cholinergic neurons in the brain stem begin to fire, +setting off erratic pulses of electrical energy called PGO (pontine- +geniculate-occipital) waves. These waves travel up the brain stem into +the visual cortex, stimulating it to create dreams. Cells in the visual +cortex begin to resonate hundreds of times per second in an irregular +fashion, which is perhaps responsible for the sometimes incoherent +nature of dreams. + +This system also emits chemicals that decouple parts of the brain +involved with reason and logic. The lack of checks coming from the +prefrontal and orbitofrontal cortices, along with the brain becoming +extremely sensitive to stray thoughts, may account for the bizarre, +erratic nature of dreams." +"Studies have shown that it is possible to enter the cholinergic state +without sleep. Dr. Edgar Garcia-Rill of the University of Arkansas claims +that meditation, worrying, or being placed in an isolation tank can +induce this cholinergic state. Pilots and drivers facing the monotony of a +blank windshield for many hours may also enter this state. In his +research, he has found that schizophrenics have an unusually large +number of cholinergic neurons in their brain stem, which may explain +some of their hallucinations. + +To make his studies more efficient, Dr. Allan Hobson had his subjects +put on a special nightcap that can automatically record data during a +dream. One sensor connected to the nightcap registers the movements of +a person’s head (because head movements usually occur when dreams +end). Another sensor measures movements of the eyelids (because REM +sleep causes eyelids to move). When his subjects wake up, they +immediately record what they dreamed about, and the information from" +"the nightcap is fed into a computer. + +In this way, Dr. Hobson has accumulated a vast amount of information +about dreams. So what is the meaning of dreams? I asked him. He +dismisses what he calls the “mystique of fortune-cookie dream +interpretation.” He does not see any hidden message from the cosmos in +dreams. + +Instead, he believes that after the PGO waves surge from the brain +stem into the cortical areas, the cortex is trying to make sense of these + +erratic signals and winds up creating a narrative out of them: a dream. + +PHOTOGRAPHING A DREAM" +"erratic signals and winds up creating a narrative out of them: a dream. + +PHOTOGRAPHING A DREAM + +In the past, most scientists avoided the study of dreams, since they are so +subjective and have such a long historical association with mystics and +psychics. But with MRI scans, dreams are now revealing their secrets. In +fact, since the brain centers that control dreaming are nearly identical to +the ones that control vision, it is therefore possible to photograph a +dream. This pioneering work is being done in Kyoto, Japan, by scientists +at the ATR Computational and Neuroscience Laboratories." +"Subjects are first placed in an MRI machine and shown four hundred +black-and-white images, each consisting of a set of dots within a ten-by- +ten-pixel framework. One picture is flashed at a time, and the MRI +records how the brain responds to each collection of pixels. As with +other groups working in this field of BMI, the scientists eventually create +an encyclopedia of images, with each image of pixels corresponding to a +specific MRI pattern. Here the scientists are able to work backward, to +correctly reconstruct self-generated images from MRI brain scans taken +while the subject dreams. + +ATR chief scientist Yukiyasu Kamitani says, “This technology can also +be applied to senses other than vision. In the future, it may also be +possible to read feelings and complicated emotional states.” In fact, any +mental state of the brain might be imaged in this way, including dreams, +as long as a one-to-one map can be made between a certain mental state +and an MRI scan." +"The Kyoto scientists have concentrated on analyzing still photographs +generated by the mind. In Chapter 3, we encountered a similar approach +pioneered by Dr. Jack Gallant, in which the voxels from 3-D MRI scans +of the brain can be used to reconstruct the actual image seen by the eye +with the help of a complex formula. A similar process has allowed Dr. + + Gallant and his team to create a crude video of a dream. When I visited +the laboratory in Berkeley, I talked to a postdoctoral staff member, Dr. +Shinji Nishimoto, who allowed me to watch the video of one of his +dreams, one of the first ever done. I saw a series of faces flickering +across the computer screen, meaning that the subject (in this case Dr." +"Nishimoto himself) was dreaming of people, rather than animals or +objects. This was amazing. Unfortunately, the technology is not yet good +enough to see the precise facial features of the people appearing in his +dream, so the next step is to increase the number of pixels so that more +complex images can be identified. Another advance will be to reproduce +images in color rather than black and white. + +I then asked Dr. Nishimoto the crucial question: How do you know the +video is accurate? How do you know that the machine isn’t just making +things up? He was a bit sheepish when he replied that this was a weak +point in his research. Normally, you have only a few minutes after +waking up to record a dream. After that, most dreams are lost in the fog +of our consciousness, so it is not easy to verify the results." +"Dr. Gallant told me that this research on videotaping dreams was still +a work in progress, and that is why it’s not ready for publication. There +is still a ways to go before we can watch a videotape of last night’s +dream. + +LUCID DREAMS + +Scientists are also investigating a form of dreaming that was once +thought to be a myth: lucid dreaming, or dreaming while you are +conscious. This sounds like a contradiction in terms, but it has been +verified in brain scans. In lucid dreaming, dreamers are aware that they +are dreaming and can consciously control the direction of the dream. +Although science has only recently begun to experiment with lucid +dreaming, there are references to this phenomenon dating back +centuries. In Buddhism, for example, there are books that refer to lucid +dreamers and how to train yourself to become one. Over the centuries, +several people in Europe have written detailed accounts of their lucid +dreams." +"Brain scans of lucid dreamers show that this phenomenon is real; +during REM sleep, their dorsolateral prefrontal cortex, which is usually +dormant when a normal person dreams, is active, indicating that the +person is partially conscious while dreaming. In fact, the more lucid the +dream, the more active the dorsolateral prefrontal cortex. Since the +dorsolateral prefrontal cortex represents the conscious part of the brain, + + the dreamer must be aware while he or she is dreaming." +"the dreamer must be aware while he or she is dreaming. + +Dr. Hobson told me that anyone can learn to do lucid dreaming by +practicing certain techniques. In particular, people who do lucid +dreaming should keep a notebook of dreams. Before going to sleep, they +should remind themselves that they will “wake up” in the middle of the +dream and realize that they are moving in a dream world. It is important +to have this frame of mind before hitting the pillow. Since the body is +largely paralyzed during REM sleep, it is difficult for the dreaming +person to send a signal to the outside world that he has entered a dream, +but Dr. Stephen LaBerge at Stanford University has studied lucid +dreamers (including himself) who can signal the outside world while +dreaming." +"In 2011, for the first time, scientists used MRI and EEG sensors to +measure dream content and even make contact with a dreaming person. +At the Max Planck Institute in Munich and Leipzig, scientists enlisted the +help of lucid dreamers, who were fitted with EEG sensors on their heads +to help the scientists determine the moment they entered REM sleep; +they were then placed in an MRI machine. Before falling asleep, the +dreamers agreed to initiate a set of eye movements and breathing +patterns when dreaming, like a Morse code. They were told that once +they started dreaming, they should clench their right fist and then their +left one for ten seconds. That was the signal that they were dreaming." +"The scientists found that, once the subjects entered their dream state, +the sensorimotor cortex of the brain (responsible for controlling motor +actions like clenching your fists) was activated. The MRI scans could +pick up that the fists were being clenched and which fist was being +clenched first. Then, using another sensor (a near-infrared spectrometer) +they were able to confirm that there was increased brain activity in the +region that controls the planning of movements. + +“Our dreams are therefore not a ‘sleep cinema’ in which we merely +observe an event passively, but involve activity in the regions of the +brain that are relevant to the dream content,” says Michael Czisch, a +group leader at the Max Planck Institute. + +ENTERING A DREAM + +If we can communicate with a dreaming person, then is it also possible +to alter someone’s dream from the outside? Quite possibly. + +First, as we have seen, scientists have already made the initial steps in" +"First, as we have seen, scientists have already made the initial steps in + + videotaping a person’s dream, and in the coming years, it should be +possible to create much more accurate pictures and videos of dreams. +Since scientists have already been able to establish a communication link +between the real world and the lucid dreamer in the fantasy world, then, +in principle, scientists should be able to deliberately alter the course of a +dream. Let’s say that scientists are viewing the video of a dream using an +MRI machine as the dream unfolds in real time. As the person wanders +around the dreamscape, the scientists can tell where he is going and give +directions for him to move in different ways. + +So in the near future, it might be possible to watch a video of a +person’s dream and actually influence its general direction. But in the +movie Inception, Leonardo DiCaprio goes much further. He is able not +only to watch another person’s dream, but also to enter it. Is this +possible?" +"We saw earlier that we are paralyzed when we dream so that we don’t +carry out our dream fantasies, which might be disastrous. However, +when people are sleepwalking, they often have their eyes open (although +their eyes look glazed over). So sleepwalkers live in a hybrid world, part +real and part dreamlike. There are many documented instances of people +walking around their homes, driving cars, cutting wood, and even +committing homicides while in this dream state, where reality and the +fantasy world are mixed. Hence it is possible that physical images that +the eye actually sees can freely interact with the fictitious images that +the brain is concocting during a dream." +"The way to enter someone’s dream, then, might be to have the subject +wear contact lenses that can project images directly onto their retinas. +Already, prototypes of Internet contact lenses are being developed at the +University of Washington in Seattle. So if the observer wanted to enter +the subject’s dream, first he would sit in a studio and have a video +camera film him. His image could then be projected onto the contact +lenses of the dreamer, creating a composite image (the image of the +observer superimposed upon the imaginary image the brain is +manufacturing). + +The observer could actually see this dream world as he wanders + +around the dream, since he, too, would be wearing Internet contact +lenses. The MRI image of the subject’s dream, after it has been +deciphered by computer, would be sent directly into the observer’s +contact lenses." +"Furthermore, you could actually change the direction of the dream +you have entered. As you walk around in the empty studio, you would +see the dream unfold in your contact lens, so you could start to interact + + with the objects and people appearing in the dream. This would be quite +an experience, since the background would change without warning, +images would appear and disappear without reason, and the laws of +physics would be suspended. Anything goes." +"Further into the future, it might even be possible to enter another +person’s dream by directly connecting two sleeping brains. Each brain +would have to be connected to MRI scanners that were connected to a +central computer, which would merge the two dreams into a single one. +The computer would first decipher each person’s MRI scans into a video +image. Then the dream of one person would be sent into the sensory +areas of the other person’s brain, so that the other dreamer’s dream +would merge with the first dreamer’s dream. However, the technology of +videotaping and interpreting dreams would have to become much more +advanced before this could become a possibility." +"But this raises another question: If it’s possible to alter the course of +someone’s dream, is it possible to control not only that person’s dream +but that person’s mind as well? During the Cold War, this became a +serious issue as both the Soviet Union and the United States played a +deadly game, trying to use psychological techniques to control other +people’s wills. + +Minds are simply what brains do. + +—MARVIN MINSKY + +8 CAN THE MIND BE CONTROLLED?" +"Minds are simply what brains do. + +—MARVIN MINSKY + +8 CAN THE MIND BE CONTROLLED? + +A raging bull is released into an empty arena in Cordoba, Spain. For +generations, this ferocious beast has been carefully bred to maximize its +killer instinct. Then a Yale professor calmly enters the same arena. +Rather than donning a tweed jacket, he is dressed like a dashing +matador, wearing a bright golden jacket and waving a red cape defiantly +in front of the bull, egging him on. Instead of running away in terror, the +professor looks calm, confident, and even detached. To a bystander, it +appears as if the professor has gone mad and wants to commit suicide." +"Enraged, the bull locks onto the professor. Suddenly the bull charges, +aiming his deadly horns at him. The professor does not run away in fear. +Instead, he holds a small box in his hand. Then, in front of the cameras, +he presses a button on the box, and the bull stops dead in his tracks. The +professor is so confident of himself that he has risked his life to prove a +point, that he has mastered the art of controlling the mind of a mad bull. + + The Yale professor is Dr. Jose Delgado, who was years ahead of his +time. He pioneered a series of remarkable but unsettling animal +experiments in the 1960s, in which he put electrodes into their brains +with the aim of trying to control their movement. To stop the bull, he +inserted electrodes into the striatum of the basal ganglia at the base of +the brain, which is involved with motor coordination." +"He also did a series of other experiments on monkeys to see if he could +rearrange their social hierarchy with the push of a button. After +implanting electrodes into the caudate nucleus (a region associated with +motor control) of the alpha male within the group, Delgado could reduce +the aggressive tendencies of the leader on command. Without threats of +retaliation, the delta males began to assert themselves, taking over the +territory and privileges normally reserved for the alpha male. The alpha +male, meanwhile, appeared to have lost interest in defending his +territory. + +Then Dr. Delgado pressed another button, and the alpha male + +instantly sprung back to normal, resuming his aggressive behavior and +reestablishing his power as the king of the hill. The delta males +scrambled in fear. + +Dr. Delgado was the first person in history to show that it was possible +to control the minds of animals in this way. The professor became the +puppet master, pulling the strings of living puppets." +"As expected, the scientific community looked at Dr. Delgado’s work +with unease. To make matters worse, he wrote a book in 1969 with the +provocative title Physical Control of the Mind: Toward a Psychocivilized +Society. It raised an unsettling question: If scientists like Dr. Delgado are +pulling the strings, then who controls the puppet master?" +"Dr. Delgado’s work puts into sharp focus the enormous promise and +perils of this technology. In the hands of an unscrupulous dictator, this +technology might be used to deceive and control his unfortunate +subjects. But it can also be used to free millions of people who are +trapped in mental illness, hounded by their hallucinations, or crushed by +their anxieties. (Years later, Dr. Delgado was asked by a journalist why +he initiated these controversial experiments. He said that he wanted to +correct the horrendous abuses being suffered by the mentally ill. They +often underwent radical lobotomies, in which the prefrontal cortex was +scrambled by a knife resembling an ice pick, which was hammered into +the brain above the eye socket. The results were often tragic, and some +of the horrors were exposed in Ken Kesey’s novel One Flew Over the +Cuckoo’s Nest, which was made into a movie with Jack Nicholson. Some" +"patients became calm and relaxed, but many others became zombies: +lethargic, indifferent to pain and feelings, and emotionally vacuous. The +practice was so widespread that in 1949, Antonio Moniz won the Nobel +Prize for perfecting the lobotomy. Ironically, in 1950, the Soviet Union +banned this technology, stating that “it was contrary to the principles of +humanity.” Lobotomies, the Soviet Union charged, turned “an insane +person into an idiot.” In total, it is estimated that forty thousand +lobotomies were performed in the United States alone over two +decades.) + +MIND CONTROL AND THE COLD WAR + +Another reason for the chilly reception of Dr. Delgado’s work was the +political climate of the time. It was the height of the Cold War, with +painful memories of captured U.S. soldiers being paraded in front of +cameras during the Korean War. With blank stares, they would admit +they were on secret spy missions, confess to horrific war crimes, and +denounce U.S. imperialism." +"To make sense of this, the press used the term “brainwashing,” the +idea that the communists had developed secret drugs and techniques to +turn U.S. soldiers into pliable zombies. In this charged political climate, +Frank Sinatra starred in the 1962 Cold War thriller The Manchurian +Candidate, in which he tries to expose a secret communist “sleeper” +agent whose mission is to assassinate the president of the United States. +But there is a twist. The assassin is actually a trusted U.S. war hero, +someone who was captured and then brainwashed by the communists. +Coming from a well-connected family, the agent seems above suspicion +and is almost impossible to stop. The Manchurian Candidate mirrored the +anxieties of many Americans at that time." +"Many of these fears were also stoked by Aldous Huxley’s prophetic +1931 novel Brave New World. In this dystopia, there are large test-tube- +baby factories that produce clones. By selectively depriving oxygen from +these fetuses, it is possible to produce children of different levels of brain +damage. At the top are the alphas, who suffer no brain damage and are +bred to rule society. At the bottom are the epsilons, who suffer +significant brain damage and are used as disposable, obedient workers. +In between are additional levels made up of other workers and the +bureaucracy. The elite then control society by flooding it with mind- +altering drugs, free love, and constant brainwashing. In this way, peace, +tranquility, and harmony are maintained, but the novel asked a +disturbing question that resonates even today: How much of our freedom +and basic humanity do we want to sacrifice in the name of peace and +social order? + + CIA MIND-CONTROL EXPERIMENTS" +"CIA MIND-CONTROL EXPERIMENTS + +The Cold War hysteria eventually reached the highest levels of the CIA. +Convinced that the Soviets were far ahead in the science of brainwashing + +and unorthodox scientific methods, the CIA embarked upon a variety of +classified projects, such as MKULTRA, which began in 1953, to explore +bizarre, fringe ideas. (In 1973, as the Watergate scandal spread panic +throughout the government, CIA director Richard Helms canceled +MKULTRA and hurriedly ordered all documents pertaining to the project +destroyed. However, a cache of twenty thousand documents somehow +survived the purge and were declassified in 1977 under the Freedom of +Information Act, revealing the full scope of this massive effort.)" +"It is now known that, from 1953 to 1973, MULTRA funded 80 +institutions, including 44 universities and colleges, and scores of +hospitals, pharmaceutical companies, and prisons, often experimenting +on unsuspecting people without their permission, in 150 secret +operations. At one point, fully 6 percent of the entire CIA budget went +into MKULTRA. + +Some of these mind-control projects included: + +• developing a “truth serum” so prisoners would spill their secrets + +• erasing memories via a U.S. Navy project called “Subproject 54” + +• using hypnosis and a wide variety of drugs, especially LSD, to +control behavior + +• investigating the use of mind-control drugs against foreign leaders, +e.g., Fidel Castro + +• perfecting a variety of interrogation methods against prisoners + +• developing a knockout drug that was fast working and left no trace + +• altering people’s personality via drugs to make them more pliable" +"• altering people’s personality via drugs to make them more pliable + +Although some scientists questioned the validity of these studies, +others went along willingly. People from a wide range of disciplines +were recruited, including psychics, physicists, and computer scientists, to +investigate a variety of unorthodox projects: experimenting with mind- +altering drugs such as LSD, asking psychics to locate the position of +Soviet submarines patrolling the deep oceans, etc. In one sad incident, a + + U.S. Army scientist was secretly given LSD. According to some reports, +he became so violently disoriented that he committed suicide by +jumping out a window." +"Most of these experiments were justified on the grounds that the +Soviets were already ahead of us in terms of mind control. The U.S. +Senate was briefed in another secret report that the Soviets were +experimenting with beaming microwave radiation directly into the +brains of test subjects. Rather than denouncing the act, the United States +saw “great potential for development into a system for disorienting or +disrupting the behavior pattern of military or diplomatic personnel.” The +U.S. Army even claimed that it might be able to beam entire words and +speeches into the minds of the enemy: “One decoy and deception +concept ... is to remotely create noise in the heads of personnel by +exposing them to low power, pulsed microwaves.... By proper choice of +pulse characteristics, intelligible speech may be created.... Thus, it may +be possible to ‘talk’ to selected adversaries in a fashion that would be +most disturbing to them,” the report said." +"Unfortunately, none of these experiments was peer-reviewed, so +millions of taxpayer dollars were spent on projects like this one, which +most likely violated the laws of physics, since the human brain cannot +receive microwave radiation and, more important, does not have the +ability to decode microwave messages. Dr. Steve Rose, a biologist at the +Open University, has called this far-fetched scheme a “neuro-scientific +impossibility.” + +But for all the millions of dollars spent on these “black projects,” +apparently not a single piece of reliable science emerged. The use of +mind-altering drugs did, in fact, create disorientation and even panic +among the subjects who were tested, but the Pentagon failed to +accomplish the key goal: control of the conscious mind of another +person." +"Also, according to psychologist Robert Jay Lifton, brainwashing by the +communists had little long-term effect. Most of the American troops who +denounced the United States during the Korean War reverted back to +their normal personalities soon after being released. In addition, studies +done on people who have been brainwashed by certain cults also show +that they revert back to their normal personality after leaving the cult. +So it seems that, in the long run, one’s basic personality is not affected +by brainwashing. + +Of course, the military was not the first to experiment with mind +control. In ancient times, sorcerers and seers would claim that giving + + magic potions to captured soldiers would make them talk or turn against +their leaders. One of the earliest of these mind-control methods was +hypnotism. + +YOU ARE GETTING SLEEPY...." +"YOU ARE GETTING SLEEPY.... + +As a child, I remember seeing TV specials devoted to hypnosis. In one +show, a person was placed in a hypnotic trance and told that when he +woke up, he would be a chicken. The audience gasped as he began to +cluck and flap his arms around the stage. As dramatic as this +demonstration was, it’s simply an example of “stage hypnosis.” Books +written by professional magicians and showmen explain that they use +shills planted in the audience, the power of suggestion, and even the +willingness of the victim to play along with the ruse. + +I once hosted a BBC/Discovery TV documentary called Time, and the +subject of long-lost memories came up. Is it possible to evoke such +distant memories through hypnosis? And if it is, can you then impose +your will on another? To test some of these ideas, I had myself +hypnotized for TV." +"BBC hired a skilled professional hypnotist to begin the process. I was +asked to lie down on a bed in a quiet, darkened room. The hypnotist +spoke to me in slow, gentle tones, gradually making me relax. After a +while, he asked me to think back into the past, to perhaps a certain place +or incident that stood out even after all these years. And then he asked +me to reenter that place, reexperiencing its sights, sounds, and smells. +Remarkably, I did begin to see places and people’s faces that I had +forgotten about decades ago. It was like watching a blurred movie that +was slowly coming into focus. But then the recollections stopped. At a +certain point, I could not recapture any more memories. There was +clearly a limit to what hypnosis could do." +"EEG and MRI scans show that during hypnosis the subject has minimal +sensory stimulation in the sensory cortices from the outside. In this way, +hypnosis can allow one to access some memories that are buried, but it +certainly cannot change one’s personality, goals, or wishes. A secret +1966 Pentagon document corroborates this, explaining that hypnotism +cannot be trusted as a military weapon. “It is probably significant that in + +the long history of hypnosis, where the potential application to +intelligence has always been known, there are no reliable accounts of its +effective use by an intelligence service,” it read." +"It should also be noted that brain scans show that hypnotism is not a +new state of consciousness, like dreaming and REM sleep. If we define +human consciousness as the process of continually building models of +the outside world and then simulating how they evolve into the future to +carry out a goal, we see that hypnosis cannot alter this basic process. +Hypnosis can accentuate certain aspects of consciousness and help +retrieve certain memories, but it cannot make you squawk like a chicken +without your permission. + +MIND-ALTERING DRUGS AND TRUTH SERUMS + +One of the goals of MKULTRA was the creation of a truth serum so that +spies and prisoners would reveal their secrets. Although MKULTRA was +canceled in 1973, U.S. Army and CIA interrogation manuals declassified +by the Pentagon in 1996 still recommended the use of truth serums +(although the U.S. Supreme Court ruled that confessions obtained in this +way were “unconstitutionally coerced” and hence inadmissible in court)." +"Anyone who watches Hollywood movies knows that sodium pentathol +is the truth serum of choice used by spies (as in the movies True Lies +with Arnold Schwarzenegger and Meet the Fockers with Robert De Niro). +Sodium pentathol is part of a larger class of barbiturates, sedatives, and +hypnotics that can evade the blood-brain barrier, which prevents most +harmful chemicals in the bloodstream from entering the brain." +"Not surprisingly, most mind-altering drugs, such as alcohol, affect us +powerfully because they can evade this barrier. Sodium pentathol +depresses activity in the prefrontal cortex, so that a person becomes +more relaxed, talkative, and uninhibited. However, this does not mean +that they tell the truth. On the contrary, people under the influence of +sodium pentathol, like those who have imbibed a few too many, are +fully capable of lying. The “secrets” that come spilling out of the mouth +of someone under this drug may be total fabrications, so even the CIA +eventually gave up on drugs like this. + +But this still leaves open the possibility that, one day, a wonder drug" +"But this still leaves open the possibility that, one day, a wonder drug + +might be found that could alter our basic consciousness. This drug would +work by changing the synapses between our nerve fibers by targeting +neurotransmitters that operate in this area, such as dopamine, serotonin, +or acetylcholine. If we think of the synapses as a series of tollbooths +along a superhighway, then certain drugs (such as stimulants like +cocaine) can open the tollbooth and let messages pass by unimpeded. +The sudden rush that drug addicts feel is caused when these tollbooths +are opened all at once, causing an avalanche of signals to flood by. But + + when all the synapses have fired in unison, they cannot fire again until +hours later. It’s as if the tolls have closed, and this causes the sudden +depression one feels after the rush. The body’s desire to reexperience the +sudden rush then causes addiction. + +HOW DRUGS ALTER THE MIND" +"HOW DRUGS ALTER THE MIND + +Although the biochemical basis for mind-altering drugs was not known +when the CIA first conducted its experiments on unsuspecting subjects, +since then the molecular basis of drug addiction has been studied in +detail. Studies in animals demonstrate how powerful drug addiction is: +rats, mice, and primates will, given the chance, take drugs like cocaine, +heroin, and amphetamines until they drop from exhaustion or die from +it." +"To see how widespread this problem has become, consider that by +2007, thirteen million Americans aged twelve or over (or 5 percent of +the entire teen and adult population of the United States) had tried or +become addicted to methamphetamines. Drug addiction not only +destroys entire lives, it also systematically destroys the brain. MRI scans +of the brains of meth addicts show an 11 percent reduction in the size of +the limbic system, which processes emotions, and an 8 percent loss of +tissue in the hippocampus, which is the gateway for memory. MRI scans +show that the damage in some ways is comparable to that found in +Alzheimer’s patients. But no matter how much meth destroys the brain, +addicts crave it because its high is up to twelve times the rush caused by +eating a delicious meal or even having sex. + +Basically, the “high” of drug addiction is due to the drug’s hijacking of +the brain’s own pleasure/reward system located in the limbic system." +"This pleasure/reward circuit is very primitive, dating back millions of +years in evolutionary history, but it is still extremely important for +human survival because it rewards beneficial behavior and punishes +harmful acts. Once this circuit is taken over by drugs, however, the +result can be widespread havoc. These drugs first penetrate the blood- +brain barrier and then cause the overproduction of neurotransmitters +like dopamine, which then floods the nucleus accumbens, a tiny pleasure +center located deep in the brain near the amygdala. The dopamine, in +turn, is produced by certain brain cells in the ventral tegmental area, +called VTA cells. + +All drugs basically work the same way: by crippling the VTA-nucleus +accumbens circuit, which controls the flow of dopamine and other +neurotransmitters to the pleasure center. Drugs differ only in the way in" +"which this process takes place. There are at least three main drugs that +stimulate the pleasure center of the brain: dopamine, serotonin, and +noradrenaline; all of them give feelings of pleasure, euphoria, and false +confidence, and also produce a burst of energy. + +Cocaine and other stimulants, for example, work in two ways. First, +they directly stimulate the VTA cells to produce more dopamine, hence +causing excess dopamine to flood into the nucleus accumbens. Second, +they prevent the VTA cells from going back to their “off” position, thus +keeping them continually producing dopamine. They also impede the +uptake of serotonin and noradrenaline. The simultaneous flooding of +neural circuits from all three of these neurotransmitters, then, creates +the tremendous high associated with cocaine. + +Heroin and other opiates, by contrast, work by neutralizing the cells in +the VTA that can reduce the production of dopamine, thus causing the +VTA to overproduce dopamine." +"Drugs like LSD operate by stimulating the production of serotonin, +inducing a feeling of well-being, purpose, and affection. But they also +activate areas of the temporal lobe involved in creating hallucinations. +(Only fifty micrograms of LSD can cause hallucinations. LSD binds so +tightly, in fact, that further increasing the dosage has no effect.) + +Over time, the CIA came to realize that mind-altering drugs were not +the magic bullet they were looking for. The hallucinations and +addictions that accompany these drugs made them too unstable and +unpredictable, and they could cause more trouble than they were worth + +in delicate political situations." +"(It should be pointed out that just in the last few years, MRI brain +scans of drug addicts have indicated a novel way to possibly cure or +treat some forms of addiction. By accident, it was noticed that stroke +victims who have damage to the insula [located deep in the brain, +between the prefrontal cortex and the temporal cortex] have a +significantly easier time quitting smoking than the average smoker. This +result has also been verified among drug abusers using cocaine, alcohol, +opiates, and nicotine. If this result holds up, it might mean that one may +be able to dampen the activity of the insula using electrodes or magnetic +stimulators and hence treat addiction. “This is the first time we’ve shown +anything like this, that damage to a specific brain area could remove the +problem of addiction entirely. It’s mind-boggling,” says Dr. Nora +Volkow, director of the National Institute on Drug Abuse. At present, no +one knows how this works, because the insula is involved in a" +"one knows how this works, because the insula is involved in a +bewildering variety of brain functions, including perception, motor +control, and self-awareness. But if this result bears out, it could change" +"the entire landscape of addiction studies.) + +PROBING THE BRAIN WITH OPTOGENETICS + +These mind-control experiments were done mainly in an era when the +brain was largely a mystery, with hit-or-miss methods that often failed. +However, because of the explosion in devices that can probe the brain, +new opportunities have arisen that will both help us understand the +brain as well as possibly teach us how to control it. + +Optogenetics, as we have seen, is one of the fastest-developing fields +in science today. The basic goal is to identify precisely which neural +pathway corresponds to which mode of behavior. Optogenetics starts +with a gene called opsin, which is quite unusual because it is sensitive to +light. (It is believed that the appearance of this gene hundreds of +millions of years ago was responsible for creating the first eye. In this +theory, a simple patch of skin sensitive to light due to opsin evolved into +the retina of the eye.)" +"When the opsin gene is inserted into a neuron and exposed to light, +the neuron will fire on command. By flipping a switch, one can instantly + +recognize the neural pathway for certain behaviors because the proteins +manufactured by opsin conduct electricity and will fire. + +The hard part, though, is to insert this gene into a single neuron. To +do this, one uses a technique borrowed from genetic engineering. The +opsin gene is inserted into a harmless virus (which has had its bad genes +removed), and, using precision tools, it is then possible to apply this +virus to a single neuron. The virus then infects the neuron by inserting +its genes into the genes of the neuron. Then, when a light beam is +flashed onto neural tissue, the neuron is turned on. In this way, one can +establish the precise pathway that certain messages take." +"Not only does optogenetics identify certain pathways by shining a +light beam on them, it also enables scientists to control behavior. +Already this method has been a proven success. It was long suspected +that a simple neural circuit must be responsible for fruit flies escaping +and flying away. Using this method, it was possible to finally identify the +precise pathway behind the quick getaway. By simply shining a beam +onto these fruit flies, they bolt on demand. + +Scientists are also now able to make worms stop wiggling by flashing +light, and in 2011 yet another breakthrough was made. Scientists at +Stanford were able to insert the opsin gene into a precise region of the + + amygdala of mice. These mice, which were specially bred to be timid, +cowered in their cage. But when a beam of light was flashed into their +brains, the mice suddenly lost their timidity and began to explore their +cage." +"The implications are enormous. While fruit flies may have simple +reflex mechanisms involving a handful of neurons, mice have complete +limbic systems with counterparts in the human brain. Although many +experiments that work with mice do not translate to human beings, this +still holds out the possibility that scientists may one day find the precise +neural pathways for certain mental illnesses, and then be able to treat +them without any side effects. As Dr. Edward Boyden of MIT says, “If +you want to turn off a brain circuit and the alternative is surgical +removal of a brain region, optical fiber implants might seem preferable.” + +One practical application is in treating Parkinson’s disease. As we have +seen, it can be treated by deep brain stimulation, but because the +positioning of electrodes in the brain lacks precision, there is always the +danger of strokes, bleeding, infections, etc. Deep brain stimulation can" +"also cause side effects such as dizziness and muscle contractions, because +the electrodes can accidentally stimulate the wrong neurons. +Optogenetics may improve deep brain stimulation by identifying the +precise neural pathways that are misfiring, at the level of individual +neurons. + +Victims of paralysis might also benefit from this new technology. As +we saw in Chapter 4, some paralyzed individuals have been hooked up +to a computer in order to control a mechanical arm, but because they +have no sense of touch, they often wind up dropping or crushing the +object they wish to grab. “By feeding information from sensors on the +prosthetic fingertips directly back to the brain using optogenetics, one +could in principle provide a high-fidelity sense of touch,” says Dr. +Krishna Shenoy of Stanford." +"Optogenetics will also help clarify which neural pathways are involved +with human behavior. In fact, plans have already been drawn up to +experiment with this technique on human brains, especially with regard +to mental illness. There will be hurdles, of course. First, the technique +requires opening up the skull, and if the neurons that one wishes to +study are located deep inside the brain, the procedure will be even more +invasive. Lastly, one has to insert tiny wires into the brain that can shine +a light on this modified neuron so that it triggers the desired behavior. + +Once these neural pathways have been deciphered, you can also +stimulate them, making animals perform strange behaviors (for example, +mice will run around in circles). Although scientists are just beginning to" +"trace the neural pathways governing simple animal behaviors, in the +future they should have an encyclopedia of such behaviors, including +those of humans. In the wrong hands, however, optogenetics could +potentially be used to control human behavior. + +In the main, the benefits of optogenetics greatly outweigh its +drawbacks. It can literally reveal the pathways of the brain in order to +treat mental illness and other diseases. This may then give scientists the +tools by which to repair the damage, perhaps curing diseases once +thought to be incurable. In the near future, then, the benefits are all +positive. But further in the future, once the pathways of human +behaviors are also understood, optogenetics could also be used to control +or at least modify human behavior as well. + +MIND CONTROL AND THE FUTURE" +"MIND CONTROL AND THE FUTURE + +In summary, the use of drugs and hypnotism by the CIA was a flop. +These techniques were too unstable and unpredictable to be of any use +to the military. They can be used to induce hallucinations and +dependency, but they have failed to cleanly erase memories, make +people more pliant, or force people to perform acts against their will. +Governments will keep trying, but the goal is elusive. So far, drugs are +simply too blunt an instrument to allow you to control someone’s +behavior. + +But this is also a cautionary tale. Carl Sagan mentions one nightmare +scenario that might actually work. He envisions a dictator taking +children and putting electrodes into their “pain” and “pleasure” centers. +These electrodes are then connected wirelessly to computers, so that the +dictator can control his subjects with the push of a button." +"Another nightmare might involve probes placed in the brain that +could override our wishes and seize control of our muscles, forcing us to +perform tasks we don’t want to do. The work of Dr. Delgado was crude, +but it showed that bursts of electricity applied to motor areas of the +brain can overrule our conscious thoughts, so that our muscles are no +longer under our control. He was able to identify only a few behaviors in +animals that could be controlled with electric probes. In the future, it +may be possible to find a wide variety of behaviors that can be +controlled electronically with a switch." +"If you are the person being controlled, it would be an unpleasant +experience. Although you may think you are master of your own body, +your muscles would actually fire without your permission, so you would +do things against your will. The electric impulse being fed into your +brain could be larger than the impulses you consciously send into your +muscles, so that it would appear as if someone had hijacked your body. + + Your own body would become a foreign object. + +In principle, some version of this nightmare might be possible in the +future. But there are several factors that may prevent this as well. First, +this is still an infant technology and it is not known how it will be +applied to human behavior, so there is still plenty of time to monitor its +development and perhaps create safeguards to see that it is not misused. +Second, a dictator might simply decide that propaganda and coercion," +"the usual methods of controlling a population, are cheaper and more +effective than putting electrodes into the brains of millions of children, +which would be costly and invasive. And third, in democratic societies, a +vigorous public debate would probably emerge concerning the promise +and limitations of this powerful technology. Laws would have to be +passed to prevent the abuse of these methods without impairing their +ability to reduce human suffering. Soon science will give us unparalleled +insight into the detailed neural pathways of the brain. A fine line has to +be drawn between technologies that can benefit society and technologies +that can control it. And the key to passing these laws is an educated, +informed public." +"But the real impact of this technology, I believe, will be to liberate the +mind, not enslave it. These technologies can give hope to those who are +trapped in mental illness. Although there is as yet no permanent cure for +mental illness, these new technologies have given us deep insight into +how such disorders form and how they progress. One day, through +genetics, drugs, and a combination of high-tech methods, we will find a +way to manage and eventually cure these ancient diseases. + +One of the recent attempts to exploit this new knowledge of the brain +is to understand historical personalities. Perhaps the insights from +modern science can help explain the mental states of those in the past. + +And one of the most mystifying figures being analyzed today is Joan +of Arc. + +Lovers and madmen have such seething brains.. +The lunatic, the lover, and the poet +Are of imagination all compact. + +-WILLIAM SHAKESPEARE, A MIDSUMMER NIGHT S DREAM + +9 ALTERED STATES OF CONSCIOUSNESS" +"-WILLIAM SHAKESPEARE, A MIDSUMMER NIGHT S DREAM + +9 ALTERED STATES OF CONSCIOUSNESS + + She was just an illiterate peasant girl who claimed to hear voices +directly from God. But Joan of Arc would rise from obscurity to lead a +demoralized army to victories that would change the course of nations, +making her one of the most fascinating, compelling, and tragic figures in +history." +"During the chaos of the Hundred Years’ War, when northern France +was decimated by English troops and the French monarchy was in +retreat, a young girl from Orleans claimed to have divine instructions to +lead the French army to victory. With nothing to lose, Charles VII +allowed her to command some of his troops. To everyone’s shock and +wonder, she scored a series of triumphs over the English. News rapidly +spread about this remarkable young girl. With each victory, her +reputation began to grow, until she became a folk heroine, rallying the +French around her. French troops, once on the verge of total collapse, +scored decisive victories that paved the way for the coronation of the +new king." +"However, she was betrayed and captured by the English. They realized +what a threat she posed to them, since she was a potent symbol for the +French and claimed guidance directly from God Himself, so they +subjected her to a show trial. After an elaborate interrogation, she was +found guilty of heresy and burned at the stake at the age of nineteen in +1431. + +In the centuries that followed, hundreds of attempts have been made +to understand this remarkable teenager. Was she a prophet, a saint, or a +madwoman? More recently, scientists have tried to use modern +psychiatry and neuroscience to explain the lives of historical figures such +as Joan of Arc. + +Few question her sincerity about claims of divine inspiration. But +many scientists have written that she might have suffered from +schizophrenia, since she heard voices. Others have disputed this fact," +"since the surviving records of her trial reveal a person of rational +thought and speech. The English laid several theological traps for her. +They asked, for example, if she was in God’s grace. If she answered yes, +then she would be a heretic, since no one can know for certain if they +are in God’s grace. If she said no, then she was confessing her guilt, and +that she was a fraud. Either way, she would lose. + +In a response that stunned the audience, she answered, “If I am not, +may God put me there; and if I am, may God so keep me.” The court +notary, in the records, wrote, “Those who were interrogating her were + + stupefied.” + +In fact, the transcripts of her interrogation are so remarkable that +George Bernard Shaw put literal translations of the court record in his +play Saint Joan." +"More recently, another theory has emerged about this exceptional +woman: perhaps she actually suffered from temporal lobe epilepsy. +People who have this condition sometimes experience seizures, but some +of them also experience a curious side effect that may shed some light on +the structure of human beliefs. These patients suffer from +“hyperreligiosity,” and can’t help thinking that there is a spirit or +presence behind everything. Random events are never random, but have +some deep religious significance. Some psychologists have speculated +that a number of history’s prophets suffered from these temporal lobe +epileptic lesions, since they were convinced they talked to God. The +neuroscientist Dr. David Eagleman says, “Some fraction of history’s +prophets, martyrs, and leaders appear to have had temporal lobe +epilepsy. Consider Joan of Arc, the sixteen-year-old girl who managed to +turn the tide of the Hundred Years’ War because she believed (and" +"turn the tide of the Hundred Years’ War because she believed (and +convinced the French soldiers) that she was hearing voices from Saint +Michael the archangel, Saint Catherine of Alexandria, Saint Margaret, +and Saint Gabriel.”" +"This curious effect was noticed as far back as 1892, when textbooks on +mental illness noted a link between “religious emotionalism” and +epilepsy. It was first clinically described in 1975 by neurologist Norman +Geschwind of Boston Veterans Administration Hospital. He noticed that +epileptics who had electrical misfirings in their left temporal lobes often +had religious experiences, and he speculated that the electrical storm in +the brain somehow was the cause of these religious obsessions. + +Dr. V. S. Ramachandran estimates that 30 to 40 percent of all the +temporal lobe epileptics whom he has seen suffer from hyperreligiosity. +He notes, “Sometimes it’s a personal God, sometimes it’s a more diffuse +feeling of being one with the cosmos. Everything seems suffused with +meaning. The patient will say, ‘Finally, I see what it is all really about, +Doctor. I really understand God. I understand my place in the universe— +the cosmic scheme.’ ”" +"He also notes that many of these individuals are extremely adamant +and convincing in their beliefs. He says, “I sometimes wonder whether +such patients who have temporal lobe epilepsy have access to another +dimension of reality, a wormhole of sorts into a parallel universe. But I +usually don’t say this to my colleagues, lest they doubt my sanity.” He +has experimented on patients with temporal lobe epilepsy, and +confirmed that these individuals had a strong emotional reaction to the + + word “God” but not to neutral words. This means that the link between +hyperreligiosity and temporal lobe epilepsy is real, not just anecdotal. + +Psychologist Michael Persinger asserts that a certain type of +transcranial electrical stimulation (called transcranial magnetic +simulation, or TMS) can deliberately induce the effect of these epileptic +lesions. If this is so, is it possible that magnetic fields can be used to alter +one’s religious beliefs?" +"In Dr. Persinger’s studies, the subject places a helmet on his head +(dubbed the “God helmet”), which contains a device that can send +magnetism into particular parts of the brain. Afterward, when the +subject is interviewed, he will often claim that he was in the presence of +some great spirit. David Biello, writing in Scientific American, says, +“During the three-minute bursts of stimulation, the affected subjects +translated this perception of the divine into their own cultural and +religious language—terming it God, Buddha, a benevolent presence, or +the wonder of the universe.” Since this effect is reproducible on demand, +it indicates that perhaps the brain is hardwired in some way to respond +to religious feelings." +"Some scientists have gone further and have speculated that there is a +“God gene” that predisposes the brain to be religious. Since most +societies have created a religion of some sort, it seems plausible that our +ability to respond to religious feelings might be genetically programmed +into our genome. (Meanwhile, some evolutionary theorists have tried to + +explain these facts by claiming that religion served to increase the +chances of survival for early humans. Religion helped bond bickering +individuals into a cohesive tribe with a common mythology, which +increased the chances that the tribe would stick together and survive.) + +Would an experiment like the one using the “God helmet” shake a +person’s religious beliefs? And can an MRI machine record the brain +activity of someone who experiences a religious awakening?" +"To test these ideas, Dr. Mario Beauregard of the University of +Montreal recruited a group of fifteen Carmelite nuns who agreed to put +their heads into an MRI machine. To qualify for the experiment, all of +them must “have had an experience of intense union with God.” + +Originally, Dr. Beauregard had hoped that the nuns would have a +mystical communion with God, which could then be recorded by an MRI +scan. However, being shoved into an MRI machine, where you are +surrounded by tons of magnetic coils of wire and high-tech equipment, is +not an ideal setting for a religious epiphany. The best they could do was +to evoke memories of previous religious experiences. “God cannot be + + summoned at will,” explained one of the nuns. + +The final result was mixed and inconclusive, but several regions of the +brain clearly lit up during this experiment: + +• The caudate nucleus, which is involved with learning and possibly +falling in love. (Perhaps the nuns were feeling the unconditional +love of God?)" +"• The insula, which monitors body sensations and social emotions. +(Perhaps the nuns were feeling close to the other nuns as they were +reaching out to God?) + +• The parietal lobe, which helps process spatial awareness. (Perhaps +the nuns felt they were in the physical presence of God?) + +Dr. Beauregard had to admit that so many areas of the brain were +activated, with so many different possible interpretations, that he could +not say for sure whether hyperreligiosity could be induced. However, it +was clear to him that the nuns’ religious feelings were reflected in their +brain scans. + +But did this experiment shake the nuns’ belief in God? No. In fact, the + +nuns concluded that God placed this “radio” in the brain so that we +could communicate with Him." +"nuns concluded that God placed this “radio” in the brain so that we +could communicate with Him. + +Their conclusion was that God created humans to have this ability, so +the brain has a divine antenna given to us by God so that we can feel His +presence. David Biello concludes, “Although atheists might argue that +finding spirituality in the brain implies that religion is nothing more +than divine delusion, the nuns were thrilled by their brain scans for +precisely the opposite reason: they seemed to provide confirmation of +God’s interactions with them.” Dr. Beauregard concluded, “If you are an +atheist and you live a certain kind of experience, you will relate it to the +magnificence of the universe. If you are a Christian, you will associate it +with God. Who knows. Perhaps they are the same thing.” + +Similarly, Dr. Richard Dawkins, a biologist at Oxford University and +an outspoken atheist, was once placed in the God helmet to see if his +religious beliefs would change. + +They did not." +"They did not. + +So in conclusion, although hyperreligiosity may be induced via +temporal lobe epilepsy and even magnetic fields, there is no convincing +evidence that magnetic fields can alter one’s religious views. + + MENTAL ILLNESS + +But there is another altered state of consciousness that brings great +suffering, both to the person experiencing it and to his or her family, and +this is mental illness. Can brain scans and high technology reveal the +origin of this affliction and perhaps lead to a cure? If so, one of the +largest sources of human suffering could be eliminated." +"For example, throughout history, the treatment of schizophrenia was +brutal and crude. People who suffer from this debilitating mental +disorder, which afflicts about 1 percent of the population, typically hear +imaginary voices and suffer from paranoid delusions and disorganized +thinking. Throughout history, they were considered to be “possessed” by +the devil and were banished, killed, or locked up. Gothic novels +sometimes refer to the strange, demented relative who lives in the +darkness of a hidden room or basement. The Bible even mentions an +incident when Jesus encountered two demoniacs. The demons begged + +Jesus to drive them into a herd of swine. He said, “Go then.” When the +demons entered the swine, the whole herd rushed down the bank and +drowned in the sea." +"Even today, you still see people with classic symptoms of +schizophrenia walking around having arguments with themselves. The +first indicators usually surface in the late teens (for men) or early +twenties (for women). Some schizophrenics have led normal lives and +even performed remarkable feats before the voices finally took over. The +most famous case is that of the 1994 Nobel Prize winner in economics, +John Nash, who was played by Russell Crowe in the movie A Beautiful +Mind. In his twenties, Nash did pioneering work in economics, game +theory, and pure mathematics at Princeton University. One of his +advisers wrote him a letter of recommendation with just one line: “This +man is a genius.” Remarkably, he was able to perform at such a high +intellectual level even while being hounded by delusions. He was finally +hospitalized when he had a breakdown at age thirty-one, and spent +many years in institutions or wandering around the world, fearing that +communist agents would kill him." +"At present, there is no precise, universally accepted way to diagnose +mental illness. There is hope, however, that one day scientists will use +brain scans and other high-tech devices to create accurate diagnostic +tools. Progress in treating mental illness, therefore, has been painfully +slow. After centuries of suffering, victims of schizophrenia had their first +sign of relief when antipsychotic drugs like thorazine were found + + accidentally in the 1950s that could miraculously control or even at +times eliminate the voices that haunted the mentally ill." +"It is believed that these drugs work by regulating the level of certain +neurotransmitters, such as dopamine. Specifically, the theory is that +these drugs block the functioning of D2 receptors of certain nerve cells, +thereby reducing the level of dopamine. (This theory, that hallucinations +were in part caused by excess dopamine levels in the limbic system and +prefrontal cortex, also explained why people taking amphetamines +experienced similar hallucinations.) + +Dopamine, because it is so essential for the synapses of the brain, has +been implicated in other disorders as well. One theory holds that +Parkinson’s disease is aggravated by a lack of dopamine in the synapses, +while Tourette’s syndrome can be triggered by an overabundance of it. + +(People with Tourette’s syndrome have tics and unusual facial +movements. A small minority of them uncontrollably speak obscene +words and make profane, derogatory remarks.)" +"More recently, scientists have zeroed in on another possible culprit: +abnormal glutamate levels in the brain. One reason for believing these +levels are involved is that PCP (angel dust) is known to create +hallucinations similar to those of schizophrenics by blocking a glutamate +receptor called NMDA. Clozapine, a relatively new drug for +schizophrenia that stimulates the production of glutamate, shows great +promise. + +However, these antipsychotic drugs are not a cure-all. In about 20 +percent of cases, such drugs stop all symptoms. About two-thirds find +some relief from their symptoms, but the rest are totally unaffected. +(According to one theory, antipsychotic drugs mimic a natural chemical +that is missing in schizophrenics’ brains, but it is not an exact copy. +Hence a patient has to try a variety of these antipsychotic drugs, almost +by trial and error. Moreover, they can have unpleasant side effects, so +schizophrenics often stop taking them and suffer a relapse.)" +"Recently, brain scans of schizophrenics taken while they were having +auditory hallucinations have helped explain this ancient disorder. For +example, when we silently talk to ourselves, certain parts of the brain +light up on an MRI scan, especially in the temporal lobe (such as in +Wernicke’s area). When a schizophrenic hears voices, the very same +areas of the brain light up. The brain works hard to construct a +consistent narrative, so schizophrenics try to make sense of these +unauthorized voices, believing they originate from strange sources, such +as Martians secretly beaming thoughts into their brains. Dr. Michael +Sweeney of Ohio State writes, “Neurons wired for the sensation of sound + + fire on their own, like gas-soaked rags igniting spontaneously in a hot, +dark garage. In the absence of sights and sounds in the surrounding +environment, the schizophrenic’s brain creates a powerful illusion of +reality.”" +"Notably, these voices seem to be coming from a third party, who often +gives the subject commands, which are mostly mundane but sometimes +violent. Meanwhile, the simulation centers in the prefrontal cortex seem +to be on automatic pilot, so in a way it’s as though the consciousness of +a schizophrenic is running the same sort of simulations we all do, except + +they’re done without his permission. The person is literally talking to +himself without his knowledge. + +HALLUCINATIONS + +The mind constantly generates hallucinations of its own, but for the +most part they are easily controlled. We see images that don’t exist or +hear spurious sounds, for example, so the anterior cingulate cortex is +vital to distinguish the real from the manufactured. This part of the +brain helps us distinguish between stimuli that are external and those +that are internally generated by the mind itself." +"However, in schizophrenics, it is believed that this system is damaged, +so that the person cannot distinguish real from imaginary voices. (The +anterior cingulate cortex is vital because it lies in a strategic place, +between the prefrontal cortex and the limbic system. The link between +these two areas is one of the most important in the brain, since one area +governs rational thinking, and the other emotions.) + +Hallucinations, to some extent, can be created on demand. +Hallucinations occur naturally if you place someone in a pitch-black +room, an isolation chamber, or a creepy environment with strange +noises. These are examples of “our eyes playing tricks on us.” Actually, +the brain is tricking itself, internally creating false images, trying to +make sense of the world and identify threats. This effect is called +“pareidolia.” Every time we look at clouds in the sky, we see images of +animals, people, or our favorite cartoon characters. We have no choice. +It is hardwired into our brains." +"In a sense, all images we see, both real and virtual, are hallucinations, +because the brain is constantly creating false images to “fill in the gaps.” +As we’ve seen, even real images are partly manufactured. But in the +mentally ill, regions of the brain such as the anterior cingulate cortex are +perhaps damaged, so the brain confuses reality and fantasy. + + THE OBSESSIVE MIND + +Another disorder in which drugs may be used to heal the mind is OCD +(obsessive-compulsive disorder). As we saw earlier, human + +consciousness involves mediating between a number of feedback +mechanisms. Sometimes, however, the feedback mechanisms are stuck in +the “on” position." +"One in forty Americans suffers from OCD. Cases can be mild, so that, +for example, people have to constantly go home to check that they +locked the door. The detective Adrian Monk on the TV show Monk has a +mild case of OCD. But OCD can also be so severe that people +compulsively scratch or wash their skin until it is left bleeding and raw. +Some people with OCD have been known to repeat obsessive behaviors +for hours, making it difficult to keep a job or have a family. + +Normally these types of compulsive behaviors, in moderation, are +actually good for us, since they help us keep clean, healthy, and safe. +That is why we evolved these behaviors in the first place. But someone +with OCD cannot stop this behavior, and it spirals out of control." +"Brain scans are now revealing how this takes place. They show that at +least three areas of the brain that normally help us keep ourselves +healthy get stuck in a feedback loop. First, there is the orbitofrontal +cortex, which we saw in Chapter 1 can act as a fact-checker, making sure +that we have properly locked the doors and washed our hands. It tells +us, “Hmm, something is wrong.” Second, the caudate nucleus, located in +the basal ganglia, governs learned activities that are automatic. It tells +the body to “do something.” And finally, we have the cingulate cortex, +which registers conscious emotions, including discomfort. It says, “I still +feel awful.”" +"Psychiatry professor Jeffrey Schwartz of UCLA has tried to put this all +together to explain how OCD gets out of hand. Imagine you have the +urge to wash your hands. The orbitofrontal cortex recognizes that +something is wrong, that your hands are dirty. The caudate nucleus kicks +in and causes you to automatically wash your hands. Then the cingulate +cortex registers satisfaction that your hands are clean. + +But in someone with OCD, this loop is altered. Even after he notices +that his hands are dirty and he washes them, he still has the +discomforting feeling that something is wrong, that they are still dirty. +So he is stuck in a feedback loop that won’t stop. + + In the 1960s, the drug clomipramine hydrochloride began to give OCD +patients some relief. This and other drugs developed since then raise +levels of the neurotransmitter serotonin in the body. They can reduce" +"symptoms of OCD by as much as 60 percent in clinical trials. Dr. +Schwartz says, “The brain’s gonna do what the brain’s gonna do, but you +don’t have to let it push you around.” These drugs are certainly not a +cure, but they have brought some relief to the sufferers of OCD. + +BIPOLAR DISORDER + +Another common form of mental illness is bipolar disorder, in which a +person suffers from extreme bouts of wild, delusional optimism, followed +by a crash and then periods of deep depression. Bipolar disorder also +seems to run in families and, curiously, strikes frequently in artists; +perhaps their great works of art were created during bursts of creativity +and optimism. A list of creative people who were afflicted by bipolar +disorder reads like a Who’s Who of Hollywood celebrities, musicians, +artists, and writers. Although the drug lithium seems to control many of +the symptoms of bipolar disorder, the causes are not entirely clear." +"One theory states that bipolar disorder may be caused by an +imbalance between the left and right hemispheres. Dr. Michael Sweeney +notes, “Brain scans have led researchers to generally assign negative +emotions such as sadness to the right hemisphere and positive emotions +such as joy to the left hemisphere. For at least a century, neuroscientists +have noticed a link between damage to the brain’s left hemisphere and +negative moods, including depression and uncontrollable crying. +Damage to the right, however, has been associated with a broad array of +positive emotions.”" +"So the left hemisphere, which is analytical and controls language, +tends to become manic if left to itself. The right hemisphere, on the +contrary, is holistic and tends to check this mania. Dr. V. S. +Ramachandran writes, “If left unchecked, the left hemisphere would +likely render a person delusional or manic.... So it seems reasonable to +postulate a ‘devil’s advocate’ in the right hemisphere that allows ‘you’ to +adopt a detached, objective (allocentric) view of yourself.” + +If human consciousness involves simulating the future, it has to +compute the outcomes of future events with certain probabilities. It +needs, therefore, a delicate balance between optimism and pessimism to +estimate the chances of success or failures for certain courses of action." +"But in some sense, depression is the price we pay for being able to +simulate the future. Our consciousness has the ability to conjure up all +sorts of horrific outcomes for the future, and is therefore aware of all the +bad things that could happen, even if they are not realistic." +"It is hard to verify many of these theories, since brain scans of people +who are clinically depressed indicate that many brain areas are affected. +It is difficult to pinpoint the source of the problem, but among the +clinically depressed, activity in the parietal and temporal lobes seems to +be suppressed, perhaps indicating that the person is withdrawn from the +outside world and living in their own internal world. In particular, the +ventromedial cortex seems to play an important role. This area +apparently creates the feeling that there is a sense of meaning and +wholeness to the world, so that everything seems to have a purpose. +Overactivity in this area can cause mania, in which people think they are +omnipotent. Underactivity in this area is associated with depression and +the feeling that life is pointless. So it is possible that a defect in this area +may be responsible for some mood swings. + +A THEORY OF CONSCIOUSNESS AND MENTAL ILLNESS" +"A THEORY OF CONSCIOUSNESS AND MENTAL ILLNESS + +So how does the space-time theory of consciousness apply to mental +illness? Can it give us a deeper insight into this disorder? As we +mentioned before, we define human consciousness as the process of +creating a model of our world in space and time (especially the future) +by evaluating many feedback loops in various parameters in order to +achieve a goal." +"We have proposed that the key function of human consciousness is to +simulate the future, but this is not a trivial task. The brain accomplishes +it by having these feedback loops check and balance one another. For +example, a skillful CEO at a board meeting tries to draw out the +disagreement among staff members and to sharpen competing points of +view in order to sift through the various arguments and then make a +final decision. In the same way, various regions of the brain make +diverging assessments of the future, which are given to the dorsolateral +prefrontal cortex, the CEO of the brain. These competing assessments are +then evaluated and weighed until a balanced final decision is made. + +We can now apply the space-time theory of consciousness to give us a +definition of most forms of mental illness: + +Mental illness is largely caused by the disruption of the +delicate checks and balances between competing feedback" +"loops that simulate the future (usually because one region of +the brain is overactive or underactive). + +Because the CEO of the mind (the dorsolateral prefrontal cortex) no +longer has a balanced assessment of the facts, due to this disruption in +feedback loops, it begins to make strange conclusions and act in bizarre +ways. The advantage of this theory is that it is testable. One has to +perform MRI scans of the brain of someone who is mentally ill as it +exhibits dysfunctional behavior, evaluating how its feedback loops are +performing, and compare it to the MRI scans of normal people. If this +theory is correct, the dysfunctional behavior (for example, hearing +voices or becoming obsessed) can be traced back to a malfunctioning of +the checks and balances between feedback loops. The theory can be +disproven if this dysfunctional behavior is totally independent of the +interplay between these regions of the brain." +"Given this new theory of mental illness, we can now apply it to +various forms of mental disorders, summarizing the previous discussion +in this new light. + +We saw earlier that the obsessive behavior of people suffering from +OCD might arise when the checks and balances between several +feedback loops are thrown out of balance: one registering something as +amiss, another carrying out corrective action, and another one signaling +that the matter has been taken care of. The failure of the checks and +balances within this loop can cause the brain to be locked into a vicious +cycle, so the mind never believes that the problem has been resolved." +"The voices heard by schizophrenics might arise when several feedback +loops are no longer balancing one another. One feedback loop generates +spurious voices in the temporal cortex (i.e., the brain is talking to itself). +Auditory and visual hallucinations are often checked by the anterior +cingulate cortex, so a normal person can differentiate between real and +fictitious voices. But if this region of the brain is not working properly, +the brain is flooded with disembodied voices that it believes are real. + +This can cause schizophrenic behavior. + +Similarly, the manic-depressive swings of someone with bipolar +disorder might be traced to an imbalance between the left and right +hemispheres. The necessary interplay between optimistic and pessimistic +assessments is thrown off balance, and the person oscillates wildly +between these two diverging moods." +"Paranoia may also be viewed in this light. It results from an imbalance +between the amygdala (which registers fear and exaggerates threats) and +the prefrontal cortex, which evaluates these threats and puts them into + + perspective. + +We should also stress that evolution has given us these feedback loops +for a reason: to protect us. They keep us clean, healthy, and socially +connected. The problem occurs when the dynamic between opposing +feedback loops is disrupted. + +This theory can be roughly summarized as follows: + +MENTAL ILLNESS + +Paranoia + +FEEDBACK LOOP #1 + +Perceiving a threat + +FEEDBACK LOOP #2 + +Discounting threats + +BRAIN REGION AFFECTED + +Amygdala/prefrontal lobe + +MENTAL ILLNESS + +Schizophrenia + +FEEDBACK LOOP #1 + +Creating voices + +FEEDBACK LOOP #2 + +Discounting voices + +BRAIN REGION AFFECTED + +Left temporal lobe/anterior cingulate cortex + +MENTAL ILLNESS + +Bipolar disorder + + FEEDBACK LOOP #1 + +Optimism + +FEEDBACK LOOP #2 + +Pessimism + +BRAIN REGION AFFECTED + +Left/right hemisphere" +"Optimism + +FEEDBACK LOOP #2 + +Pessimism + +BRAIN REGION AFFECTED + +Left/right hemisphere + +MENTAL ILLNESS + +OCD + +FEEDBACK LOOP #1 + +Anxiety + +FEEDBACK LOOP #2 + +Satisfaction + +BRAIN REGION AFFECTED + +Orbitofrontal cortex/caudate nucleus/cingulate cortex + +According to the space-time theory of consciousness, many forms of mental illness are typified by the +disruption of the +checks and balances of opposing feedback loops in the brain that simulate the future. Brain scans are +gradually +identifying which regions these are. A more complete understanding of mental illness will undoubtedly +reveal the +involvement of many more regions of the brain. This is only a preliminary sketch. + +DEEP BRAIN STIMULATION + +Although the space-time theory of consciousness may give us insight into +the origin of mental illness, it doesn’t tell us how to create new therapies +and remedies." +"How will science deal with mental illness in the future? This is hard to +predict, since we now realize that mental illness is not just one category, +but an entire range of illnesses that can afflict the mind in a bewildering +number of ways. Furthermore, the science behind mental illness is still in + + its infancy, with huge areas totally unexplored and unexplained. + +But a new method is being tried today to treat the unending agony of +people suffering from one of the most common yet stubbornly persistent +forms of mental disorder, depression, which afflicts twenty million +people in the United States. Ten percent of them, in turn, suffer from an +incurable form of depression that has resisted all medical advances. One +direct way of treating them, which holds much promise, is to place +probes deep inside certain regions of the brain." +"An important clue to this disorder was discovered by Dr. Helen +Mayberg and colleagues, then doing research at Washington University +Medical School. Using brain scans, they identified an area of the brain, +called Brodmann area 25 (also called the subcallosal cingulate region), +in the cerebral cortex that is consistently hyperactive in depressed +individuals for whom all other forms of treatment have been +unsuccessful." +"These scientists used deep brain stimulation (DBS) in this area, +inserting a small probe into the brain and applying an electrical shock, +much like a pacemaker. The success of DBS has been astonishing in the +treatment of various disorders. In the past decade, DBS has been used on +forty thousand patients for motor-related diseases, such as Parkinson’s +and epilepsy, which cause uncontrolled movements of the body. +Between 60 and 100 percent of patients report significant improvement +in controlling their shaking hands. More than 250 hospitals in the United +States alone now perform DBS treatments. + +But then Dr. Mayberg had the idea of applying DBS directly to +Brodmann area 25 to treat depression as well. Her team took twelve +patients who were clinically depressed and had shown no improvement +after exhaustive use of drugs, psychotherapy, and electroshock therapy." +"They found that eight of these chronically depressed individuals +immediately showed progress. Their success was so astonishing, in fact, +that other groups raced to duplicate these results and apply DBS to other +mental disorders. At present, DBS is being applied to thirty-five patients +at Emory University, and thirty at other institutions. + +Dr. Mayberg says, “Depression 1.0 was psychotherapy—people +arguing about whose fault it was. Depression 2.0 was the idea that it’s a +chemical imbalance. This is Depression 3.0. What has captured +everyone’s imagination is that, by dissecting a complex behavior + +disorder into its component systems, you have a new way of thinking +about it.”" +"disorder into its component systems, you have a new way of thinking +about it.” + + Although the success of DBS in treating depressed individuals is +remarkable, much more research needs to be done. First, it is not clear +why DBS works. It is thought that DBS destroys or impairs overactive +areas of the brain (as in Parkinson’s and Brodmann area 25) and is hence +effective only against ailments caused by such overactivity. Second, the +precision of this tool needs to be improved. Although this treatment has +been used to treat a variety of brain diseases, such as phantom limb pain +(when a person feels pain from a limb that has been amputated), +Tourette’s syndrome, and obsessive-compulsive disorder, the electrode +inserted into the brain is not precise, thus affecting perhaps several +million neurons rather than just the handful that are the source of +distress." +"Time will only improve the effectiveness of this therapy. Using MEM +technology, one can create microscopic electrodes able to stimulate only +a few neurons at a time. Nanotechnology may also make possible neural +nanoprobes that are one molecule thick, as in carbon nanotubes. And as +MRI sensitivity increases, our capability to guide these electrodes to +more specific areas of the brain should grow more precise. + +WAKING UP FROM A COMA + +Deep brain stimulation has branched into several different avenues of +research, including a beneficial side effect: increasing the number of +memory cells within the hippocampus. Yet another application is to +revive some individuals in a coma." +"Comas represent perhaps one of the most controversial forms of +consciousness, and often results in national headlines. The case of Terri +Schiavo, for example, riveted the public. Due to a heart attack, she +suffered a lack of oxygen, which caused massive brain injury. As a result, +Schiavo went into a coma in 1990. Her husband, with the approval of +doctors, wanted to allow her the dignity of dying peacefully. But her +family said this was cruelly pulling the plug on someone who still had +some responses to stimuli and might one day be miraculously revived. +They pointed out that there had been sensational cases in the past when + +coma patients suddenly regained consciousness after many years in a +vegetative state. + +Brain scans were used to settle the question. In 2003, most +neurologists, examining the CAT scans, concluded that the damage to +Schiavo’s brain was so extensive that she could never be revived, and +that she was in a permanent vegetative state (PVS). After she died in" +"2005, an autopsy confirmed these results—there was no chance of +revival. + +In some other cases involving coma patients, however, brain scans +show that the damage is not so severe, so there is a slim chance of +recovery. In the summer of 2007, a man in Cleveland woke up and +greeted his mother after undergoing deep brain stimulation. The man +had suffered extensive brain damage eight years earlier and fell into a +deep coma known as a minimally conscious state." +"Dr. Ali Rezai led the team of surgeons who performed the operation. +They inserted a pair of wires into the patient’s brain until they reached +the thalamus, which, as we have seen, is the gateway where sensory +information is first processed. By sending a low-voltage current through +these wires, the doctors were able to stimulate the thalamus, which in +turn woke the man up from his deep coma. (Usually, sending electricity +into the brain causes that part of the brain to shut down, but under +certain circumstances it can act to jolt neurons into action.)" +"Improvements in DBS technology should increase the number of +success stories in different fields. Today a DBS electrode is about 1.5 +millimeters in diameter, but it touches up to a million neurons when +inserted into the brain, which can cause bleeding and damage to blood +vessels. One to three percent of DBS patients in fact have bleeding that +can progress to a stroke. The electric charge carried by DBS probes is +also still very crude, pulsing at a constant rate. Eventually, surgeons will +be able to adjust the electrical charge carried by the electrodes so that +each probe is made for a specific person and a specific ailment. The next +generation of DBS probes is bound to be safer and more precise. + +THE GENETICS OF MENTAL ILLNESS + +Another attempt to understand and eventually treat mental illness" +"Another attempt to understand and eventually treat mental illness + +involves tracing its genetic roots. Many attempts have been made in this +area, with disappointing, mixed results. There is considerable evidence +that schizophrenia and bipolar disorder run in families, but attempts to +find the genes common to all these individuals have not been conclusive. +Occasionally scientists have followed the family trees of certain +individuals afflicted by mental illness and found a gene that is prevalent. +But attempts to generalize this result to other families have often failed. +At best, scientists have concluded that environmental factors as well as a +combination of several genes are necessary to trigger mental illness. +However, it has generally been accepted that each disorder has its own +genetic basis." +"In 2012, however, one of the most comprehensive studies ever done +showed that there could in fact be a common genetic factor to mental +illness after all. Scientists from the Harvard Medical School and +Massachusetts General Hospital analyzed sixty thousand people +worldwide and found that there was a genetic link between five major +mental illnesses: schizophrenia, bipolar disorder, autism, major +depression, and attention deficit hyperactivity disorder (ADHD). +Together they represent a significant fraction of all mentally ill patients." +"After an exhaustive analysis of the subjects’ DNA, scientists found that +four genes increased the risk of mental illness. Two of them involved the +regulation of calcium channels in neurons. (Calcium is an essential +chemical involved in the processing of neural signals.) Dr. Jordan +Smoller of the Harvard Medical School says, “The calcium channels +findings suggest that perhaps—and that is a big if—treatments to affect +calcium channeling functioning might have effects across a range of +disorders.” Already, calcium channel blockers are being used to treat +people with bipolar disorder. In the future, these blockers may be used +to treat other mental illnesses as well. + +This new result could help explain the curious fact that when mental +illness runs in a family, members may manifest different forms of +disorders. For example, if one twin has schizophrenia, then the other +twin might have a totally different disorder, such as bipolar disorder." +"The point here is that although each mental illness has its own triggers +and genes, there could be a common thread running through them as +well. Isolating the common factors among these diseases could give us a +clue to which drugs might be most effective against them. + +“What we have identified here is probably just the tip of the iceberg,” +says Dr. Smoller. “As these studies grow, we expect to find additional +genes that might overlap.” If more genes are found among these five +disorders, it could open up an entirely new approach to mental illness. + +If more common genes are found, it could mean that gene therapy +might be able to repair the damage caused by defective genes. Or it +might give rise to new drugs that could treat the illness at the neural +level. + +FUTURE AVENUES + +So at present, there is no cure for patients with mental illness. +Historically, doctors were helpless in treating them. But modern" +"medicine has given us a variety of new possibilities and therapies to +tackle this ancient problem. Just a few of them include: + +1. Finding new neurotransmitters and new drugs that regulate the +signaling of neurons. + +2. Locating the genes linked to various mental illnesses, and perhaps +using gene therapy. + +3. Using deep brain stimulation to dampen or increase neural activity +in certain areas. + +4. Using EEG, MRI, MEG, and TES to understand precisely how the +brain malfunctions. + +5. And in the chapter on reverse engineering the brain, we will +explore yet another promising avenue, imaging the entire brain and +all its neural pathways. This may finally unravel the mystery of +mental illnesses. + +But to make sense of the wide variety of mental illnesses, some +scientists believe that mental illnesses can be grouped into at least two +major groups, each one requiring a different approach: + +1. Mental disorders involving injury to the brain" +"1. Mental disorders involving injury to the brain + +2. Mental disorders triggered by incorrect wiring within the brain + +The first type includes Parkinson’s, epilepsy, Alzheimer’s, and a wide +variety of disorders caused by strokes and tumors, in which brain tissue +is actually injured or malfunctioning. In the case of Parkinson’s and +epilepsy, there are neurons in a precise area of the brain that are +overactive. In Alzheimer’s, a buildup of amyloid plaque destroys brain +tissue, including the hippocampus. In strokes and tumors, certain parts +of the brain are silenced, causing numerous behavioral problems. Each +of these disorders has to be treated differently, since each injury is +different. Parkinson’s and epilepsy may require probes to silence the +overactive areas, while damage from Alzheimer’s, strokes, and tumors is +often incurable." +"In the future, there will be advances in methods to deal with these +injured parts of the brain besides deep brain stimulation and magnetic +fields. One day stem cells may replace brain tissue that has been +damaged. Or perhaps artificial replacements can be found to compensate +for these injured areas using computers. In this case, the injured tissue is +removed or replaced, either organically or electronically. + + The second category involves disorders caused by a miswiring of the +brain. Disorders like schizophrenia, OCD, depression, and bipolar +disorder might fall into this category. Each region of the brain may be +relatively healthy and intact, but one or more of them may be miswired, +causing messages to be processed incorrectly. This category is difficult to +treat, since the wiring of the brain is not well understood. So far, the +main way to deal with these disorders is through drugs that influence +neurotransmitters, but there is still a lot of hit or miss involved here." +"But there is another altered state of consciousness that has given us +new insights into the working mind. It has also provided new +perspectives on how the brain works and what might happen if there is a +disorder. This is the field of AI, artificial intelligence. Although it is still +in its infancy, it has opened profound insights into the thinking process +and has even deepened our understanding of human consciousness. So +the questions are: Can silicon consciousness be achieved? If so, how +might it differ from human consciousness? And will it try one day to +control us? + +No, I’m not interested in developing a powerful brain. All I’m +after is just a mediocre brain, something like the President of +the American Telephone and Telegraph Company. + +—ALAN TURING + +10 THE ARTIFICIAL MIND AND SILICON +CONSCIOUSNESS + +In February 2011, history was made." +"10 THE ARTIFICIAL MIND AND SILICON +CONSCIOUSNESS + +In February 2011, history was made. + +An IBM computer called Watson did what many critics thought was +impossible: it beat two contestants on a TV game show called Jeopardy! +Millions of viewers were glued to the screen as Watson methodically +annihilated its opponents on national TV, answering questions that +stumped the rival contestants, and thereby claiming the $1 million prize +money. + +IBM pulled out all the stops in assembling a machine with a truly +monumental amount of computational firepower. Watson can process +data at the astonishing rate of five hundred gigabytes per second (or the +equivalent of a million books per second) with sixteen trillion bytes of +RAM memory. It also had access to two hundred million pages of +material in its memory, including the entire storehouse of knowledge + + within Wikipedia. Watson could then analyze this mountain of +information on live TV." +"within Wikipedia. Watson could then analyze this mountain of +information on live TV. + +Watson is just the latest generation of “expert systems,” software +programs that use formal logic to access vast amounts of specialized +information. (When you talk on the phone to a machine that gives you a +menu of choices, this is a primitive expert system.) Expert systems will +continue to evolve, making our lives more convenient and efficient. + +For example, engineers are currently working to create a “robo-doc,” +which will appear on your wristwatch or wall screen and give you basic +medical advice with 99 percent accuracy almost for free. You’d talk to it +about your symptoms, and it would access the databanks of the world’s +leading medical centers for the latest scientific information. This will +reduce unnecessary visits to the doctor, eliminate costly false alarms, +and make it effortless to have regular conversations with a doctor." +"Eventually we might have robot lawyers that can answer all common +legal questions, or a robo-secretary that can plan vacations, trips, and + +dinners. (Of course, for specialized services requiring professional +advice, you would still need to see a real doctor, lawyer, etc., but for +common, everyday advice, these programs would suffice.) + +In addition, scientists have created “chat-bots” that can mimic +ordinary conversations. The average person may know tens of thousands +of words. Reading the newspaper may require about two thousand words +or more, but a casual conversation usually involves only a few hundred. +Robots can be programmed to converse with this limited vocabulary (as +long as the conversation is limited to certain well-defined subjects). + +MEDIA HYPE—THE ROBOTS ARE COMING" +"MEDIA HYPE—THE ROBOTS ARE COMING + +Soon after Watson won that contest, some pundits were wringing their +hands, mourning the day when the machines will take over. Ken +Jennings, one of the contestants defeated by Watson, remarked to the +press, “I for one welcome our new computer overlords.” The pundits +asked, If Watson could defeat seasoned game show contestants in a +head-to-machine contest, then what chance do the rest of us mortals +have to stand up to the machines? Half jokingly, Jennings said, “Brad +[the other contestant] and I were the first knowledge-industry workers +put out of work by the new generation of ‘thinking’ machines.” + +The commentators, however, forgot to mention that you could not go +up to Watson and congratulate it for winning. You could not slap it on" +"its back, or share a champagne toast with it. It wouldn’t know what any +of that meant, and in fact Watson was totally unaware that it had won at +all. All the hype aside, the truth is that Watson is a highly sophisticated +adding machine, able to add (or search data files) billions of times faster +than the human brain, but it is totally lacking in self-awareness or +common sense. + +On one hand, progress in artificial intelligence has been astounding, +especially in the area of raw computational power. Someone from the +year 1900, viewing the calculations performed by computers today, +would consider these machines to be miracles. But in another sense, +progress has been painstakingly slow in building machines that can think +for themselves (i.e., true automatons, without a puppet master, a +controller with a joystick, or someone with a remote-control panel). + +Robots are totally unaware that they are robots." +"Robots are totally unaware that they are robots. + +Given the fact that computer power has been doubling every two years +for the past fifty years under Moore’s law, some say it is only a matter of +time before machines eventually acquire self-awareness that rivals +human intelligence. No one knows when this will happen, but humanity +should be prepared for the moment when machine consciousness leaves +the laboratory and enters the real world. How we deal with robot +consciousness could decide the future of the human race. + +BOOM AND BUST CYCLES IN AI" +"BOOM AND BUST CYCLES IN AI + +It is difficult to foretell the fate of AI, since it has gone through three +cycles of boom and bust. Back in the 1950s, it seemed as if mechanical +maids and butlers were just around the corner. Machines were being +built that could play checkers and solve algebra problems. Robot arms +were developed that could recognize and pick up blocks. At Stanford +University, a robot was built called Shakey—basically a computer sitting +on top of wheels with a camera—which could wander around a room by +itself, avoiding obstacles." +"Breathless articles were soon published in science magazines heralding +the coming of the robot companion. Some predictions were too +conservative. In 1949, Popular Mechanics stated that “in the future, +computers will weigh no more than 1.5 tons.” But others were wildly +optimistic in proclaiming that the day of the robots was near. Shakey +would one day become a mechanical maid or butler that would vacuum +our carpets and open our doors. Movies like 2001: A Space Odyssey +convinced us that robots would soon be piloting our rocket ships to +Jupiter and chatting with our astronauts. In 1965, Dr. Herbert Simon, + + one of the founders of AI, said flatly, “Machines will be capable, within +20 years, of doing any work a man can do.” Two years later, another +founding father of AI, Dr. Marvin Minsky, said that “within a +generation ... the problem of creating ‘artificial intelligence’ will +substantially be solved.”" +"But all this unbounded optimism collapsed in the 1970s. Checker¬ +playing machines could only play checkers, nothing more. Mechanical +arms could pick up blocks, but nothing else. They were like one-trick + +ponies. The most advanced robots took hours just to walk across a room. +Shakey, placed in an unfamiliar environment, would easily get lost. And +scientists were nowhere near understanding consciousness. In 1974, AI +suffered a huge blow when both the U.S. and British governments +substantially curtailed funding in the field." +"But as computer power steadily increased in the 1980s, a new gold +rush occurred in AI, fueled mainly by Pentagon planners hoping to put +robot soldiers on the battlefield. Funding for AI hit a billion dollars by +1985, with hundreds of millions of dollars spent on projects like the +Smart Truck, which was supposed to be an intelligent, autonomous truck +that could enter enemy lines, do reconnaissance by itself, perform +missions (such as rescuing prisoners), and then return to friendly +territory. Unfortunately, the only thing that the Smart Truck did was get +lost. The visible failures of these costly projects created yet another AI +winter in the 1990s. + +Paul Abrahams, commenting about the years he spent at MIT as a +graduate student, has said, “It’s as though a group of people had +proposed to build a tower to the moon. Each year, they point with pride +at how much higher the tower is than it was the previous year. The only +trouble is that the moon isn’t getting much closer.”" +"But now, with the relentless march of computer power, a new AI +renaissance has begun, and slow but substantial progress has been made. +In 1997, IBM’s Deep Blue computer beat world chess champion Garry +Kasparov. In 2005, a robot car from Stanford won the DARPA Grand +Challenge for a driverless car. Milestones continue to be reached. + +This question remains: Is the third try the charm? + +Scientists now realize that they vastly underestimated the problem, +because most human thought is actually subconscious. The conscious +part of our thoughts, in fact, represents only the tiniest portion of our +computations. + +Dr. Steve Pinker says, “I would pay a lot for a robot that would put + + away the dishes or run simple errands, but I can’t, because all of the +little problems that you’d need to solve to build a robot do to that, like +recognizing objects, reasoning about the world, and controlling hands +and feet, are unsolved engineering problems.”" +"Although Hollywood movies tell us that terrifying Terminator robots +may be just around the corner, the task of creating an artificial mind has + +been much more difficult than previously thought. I once asked Dr. +Minsky when machines would equal and perhaps even surpass human +intelligence. He said that he was confident this would happen but that +he doesn’t make predictions about dates anymore. Given the roller¬ +coaster history of AI, perhaps this is the wisest approach, to map out the +future of AI without setting a specific timetable. + +PATTERN RECOGNITION AND COMMON SENSE + +There are at least two basic problems confronting AI: pattern recognition +and common sense." +"There are at least two basic problems confronting AI: pattern recognition +and common sense. + +Our best robots can barely recognize simple objects like a cup or a +ball. The robot’s eye may see details better than a natural eye, but the +robot brain cannot recognize what it is seeing. If you place a robot on a +strange, busy street, it quickly becomes disoriented and gets lost. Pattern +recognition (e.g., identifying objects) has progressed much more slowly +than previously estimated because of this problem." +"When a robot walks into a room, it has to perform trillions of +calculations, breaking down the objects it sees into pixels, lines, circles, +squares, and triangles, and then trying to make a match with the +thousands of images stored in its memory. For instance, robots see a +chair as a hodgepodge of lines and dots, but they cannot easily identify +the essence of “chairness.” Even if a robot is able to successfully match +an object to an image in its database, a slight rotation (like a chair that’s +been knocked over on the floor) or change in perspective (viewing the +chair from a different angle) will mystify the robot. Our brains, however, +automatically take different perspectives and variations into account. +Our brains are subconsciously performing trillions of calculations, but +the process seems effortless to us." +"Robots also have a problem with common sense. They do not +understand simple facts about the physical and biological world. There +isn’t an equation that can confirm something as self-evident (to us +humans) as “muggy weather is uncomfortable” or “mothers are older +than their daughters.” There has been some progress made in translating + + this sort of information into mathematical logic, but to catalog the +common sense of a four-year-old child would require hundreds of + +millions of lines of computer code. As Voltaire once said, “Common +sense is not so common.” + +For example, one of our most advanced robots is called ASIMO, built +in Japan (where 30 percent of all industrial robots are made) by the +Honda Corporation. This marvelous robot, about the size of a young boy, +can walk, run, climb stairs, speak different languages, and dance (much +better than I do, in fact). I have interacted with ASIMO on TV several +times, and was very impressed by its abilities." +"However, I met privately with the creators of ASIMO and asked them +this key question: How smart is ASIMO, if we compare it to an animal? +They admitted to me that it has the intelligence of a bug. All the walking +and talking is mostly for the press. The problem is that ASIMO is, by and +large, a big tape recorder. It has only a modest list of truly autonomous +functions, so almost every speech or motion has to be carefully scripted +ahead of time. For example, it took about three hours to film a short +sequence of me interacting with ASIMO, because the hand gesture and +other movement had to be programmed by a team of handlers." +"If we consider this in relation to our definition of human +consciousness, it seems that our current robots are stuck at a very +primitive level, simply trying to make sense of the physical and social +world by learning basic facts. As a consequence, robots are not even at +the stage where they can plot realistic simulations of the future. Asking a +robot to craft a plan to rob a bank, for instance, assumes that the robot +knows all the fundamentals about banks, such as where the money is +stored, what sort of security system is in place, and how the police and +bystanders will react to the situation. Some of this can be programmed, +but there are hundreds of nuances that the human mind naturally +understands but robots do not." +"Where robots excel is in simulating the future in just one precise field, +such as playing chess, modeling the weather, tracing the collision of +galaxies, etc. Since the laws of chess and gravity have been well known +for centuries, it is only a matter of raw computer power to simulate the +future of a chess game or a solar system. + +Attempts to move beyond this level using brute force have also +floundered. One ambitious program, called CYC, was designed to solve +the commonsense problem. CYC would include millions of lines of +computer code containing all the information of common sense and + + knowledge necessary to understand its physical and social environment. +Although CYC can process hundreds of thousands of facts and millions of +statements, it still cannot reproduce the level of thought of a four-year- +old human. Unfortunately, after some optimistic press releases, the effort +has stagnated. Many of its programmers left, deadlines have come and +gone, and yet the project still continues." +"IS THE BRAIN A COMPUTER? + +Where did we go wrong? For the past fifty years, scientists working in AI +have tried to model the brain by following the analogy with digital +computers. But perhaps this was too simplistic. As Joseph Campbell once +said, “Computers are like Old Testament gods; lots of rules and no +mercy.” If you remove a single transistor from a Pentium chip, the +computer will crash immediately. But the human brain can perform +quite well even if half of it is missing." +"This is because the brain is not a digital computer at all, but a highly +sophisticated neural network of some sort. Unlike a digital computer, +which has a fixed architecture (input, output, and processor), neural +networks are collections of neurons that constantly rewire and reinforce +themselves after learning a new task. The brain has no programming, no +operating system, no Windows, no central processor. Instead, its neural +networks are massively parallel, with one hundred billion neurons firing +at the same time in order to accomplish a single goal: to learn." +"In light of this, AI researchers are beginning to reexamine the “top- +down approach” they have followed for the last fifty years (e.g., putting +all the rules of common sense on a CD). Now AI researchers are giving +the “bottom-up approach” a second look. This approach tries to follow +Mother Nature, which has created intelligent beings (us) via evolution, +starting with simple animals like worms and fish and then creating more +complex ones. Neural networks must learn the hard way, by bumping +into things and making mistakes. + +Dr. Rodney Brooks, former director of the famed MIT Artificial +Intelligence Laboratory, and cofounder of iRobot, which makes those +mechanical vacuum cleaners found in many living rooms, introduced an +entirely new approach to AI. Instead of designing big, clumsy robots," +"why not build small, compact, insectlike robots that have to learn how +to walk, just as in nature?When I interviewed him, he told me that he +used to marvel at the mosquito, which had a nearly microscopic brain +with very few neurons, yet was able to maneuver in space better than + + any robot airplane. He built a series of remarkably simple robots, +affectionately called “insectoids” or “bugbots,” which scurried around +the floors of MIT and could run circles around the more traditional +robots. The goal was to create robots that follow the trial-and-error +method of Mother Nature. In other words, these robots learn by bumping +into things. + +(At first, it may seem that this requires a lot of programming. The +irony, however, is that neural networks require no programming at all. +The only thing that the neural network does is rewire itself, by changing +the strength of certain pathways each time it makes a right decision. So +programming is nothing; changing the network is everything.)" +"Science-fiction writers once envisioned that robots on Mars would be +sophisticated humanoids, walking and moving just like us, with complex +programming that gave them human intelligence. The opposite has +happened. Today the grandchildren of this approach—like the Mars +Curiosity rover—are now roaming over the surface of Mars. They are not +programmed to walk like a human. Instead, they have the intelligence of +a bug, but they do quite fine in this terrain. These Mars rovers have +relatively little programming; instead, they learn as they bump into +obstacles. + +ARE ROBOTS CONSCIOUS?" +"ARE ROBOTS CONSCIOUS? + +Perhaps the clearest way to see why true robot automatons do not yet +exist is to rank their level of consciousness. As we have seen in Chapter +2, we can rank consciousness in four levels. Level 0 consciousness +describes thermostats and plants; that is, it involves a few feedback loops +in a handful of simple parameters such as temperature or sunlight. Level +I consciousness describes insects and reptiles, which are mobile and have +a central nervous system; it involves creating a model of your world in +relationship to a new parameter, space. Then we have Level II +consciousness, which creates a model of the world in relationship to + +others of its kind, requiring emotions. Finally we have Level III +consciousness, which describes humans, who incorporate time and self- +awareness to simulate how things will evolve in the future and +determine our own place in these models." +"We can use this theory to rank the robots of today. The first +generation of robots were at Level 0, since they were static, without +wheels or treads. Today’s robots are at Level I, since they are mobile, but +they are at a very low echelon because they have tremendous difficulty +navigating in the real world. Their consciousness can be compared to +that of a worm or slow insect. To fully produce Level I consciousness, + + scientists will have to create robots that can realistically duplicate the +consciousness of insects and reptiles. Even insects have abilities that +current robots do not have, such as rapidly finding hiding places, +locating mates in the forest, recognizing and evading predators, or +finding food and shelter." +"As we mentioned earlier, we can numerically rank consciousness by +the number of feedback loops at each level. Robots that can see, for +example, may have several feedback loops because they have visual +sensors that can detect shadows, edges, curves, geometric shapes, etc., in +three-dimensional space. Similarly, robots that can hear require sensors +that can detect frequency, intensity, stress, pauses, etc. The total number +of these feedback loops may total ten or so (while an insect, because it +can forage in the wild, find mates, locate shelter, etc., may have fifty or +more feedback loops). A typical robot, therefore, may have Level 1:10 +consciousness." +"Robots will have to be able to create a model of the world in relation +to others if they are to enter Level II consciousness. As we mentioned +before, Level II consciousness, to a first approximation, is computed by +multiplying the number of members of its group times the number of +emotions and gestures that are used to communicate between them. +Robots would thus have a consciousness of Level 11:0. But hopefully, the +emotional robots being built in labs today may soon raise that number. + +Current robots view humans as simply a collection of pixels moving on +their TV sensors, but some AI researchers are beginning to create robots +that can recognize emotions in our facial expressions and tone of voice. +This is a first step toward robots’ realizing that humans are more than +just random pixels, and that they have emotional states." +"In the next few decades, robots will gradually rise in Level II +consciousness, becoming as intelligent as a mouse, rat, rabbit, and then a +cat. Perhaps late in this century, they will be as intelligent as a monkey, +and will begin to create goals of their own. + +Once robots have a working knowledge of common sense and the +Theory of Mind, they will be able to run complex simulations into the +future featuring themselves as the principal actors and thus enter Level +III consciousness. They will leave the world of the present and enter the +world of the future. This is many decades beyond the capability of any +robot today. Running simulations of the future means that you have a +firm grasp of the laws of nature, causality, and common sense, so that +you can anticipate future events. It also means that you understand +human intentions and motivations, so you can predict their future +behavior as well." +"The numerical value of Level III consciousness, as we mentioned, is +calculated by the total number of causal links one can make in +simulating the future in a variety of real-life situations, divided by the +average value of a control group. Computers today are able to make +limited simulations in a few parameters (e.g., the collision of two +galaxies, the flow of air around an airplane, the shaking of buildings in +an earthquake), but they are totally unprepared to simulate the future in +complex, real-life situations, so their level of consciousness would be +something like Level III: 5. + +As we can see, it may take many decades of hard work before we have +a robot that can function normally in human society. + +SPEED BUMPS ON THE WAY" +"SPEED BUMPS ON THE WAY + +So when might robots finally match and exceed humans in intelligence? +No one knows, but there have been many predictions. Most of them rely +on Moore’s law extending decades into the future. However, Moore’s law +is not a law at all, and in fact it ultimately violates a fundamental +physical law: the quantum theory. + +As such, Moore’s law cannot last forever. In fact, we can already see it +slowing down now. It might flatten out by the end of this or the next +decade, and the consequences could be dire, especially for Silicon Valley." +"The problem is simple. Right now, you can place hundreds of millions +of silicon transistors on a chip the size of your fingernail, but there is a +limit to how much you can cram onto these chips. Today the smallest +layer of silicon in your Pentium chip is about twenty atoms in width, +and by 2020 that layer might be five atoms across. But then Heisenberg’s +uncertainty principle kicks in, and you wouldn’t be able to determine +precisely where the electron is and it could “leak out” of the wire. (See +the Appendix, where we discuss the quantum theory and the uncertainty +principle in more detail.) The chip would short-circuit. In addition, it +would generate enough heat to fry an egg on it. So leakage and heat will +eventually doom Moore’s law, and a replacement will soon be necessary." +"If packing transistors on flat chips is maxing out in computing power, +Intel is making a multibillion-dollar bet that chips will rise into the third +dimension. Time will tell if this gamble pays off (one major problem +with 3-D chips is that the heat generated rises rapidly with the height of +the chip). + +Microsoft is looking into other options, such as expanding into 2-D +with parallel processing. One possibility is to spread chips horizontally + + in a row. Then you break up a software problem into pieces, sort out +each piece on a small chip, and reassemble it at the end. However, it +may be a difficult process, and software grows at a much slower pace +than the supercharged exponential rate we are accustomed to with +Moore’s law." +"These stopgap measures may add years to Moore’s law. But eventually, +all this must pass, too: the quantum theory inevitably takes over. This +means that physicists are experimenting with a wide variety of +alternatives after the Age of Silicon draws to a close, such as quantum +computers, molecular computers, nanocomputers, DNA computers, +optical computers, etc. None of these technologies, however, is ready for +prime time. + +THE UNCANNY VALLEY + +But assume for the moment that one day we will coexist with incredibly +sophisticated robots, perhaps using chips with molecular transistors +instead of silicon. How closely do we want our robots to look like us?" +"Japan is the world’s leader in creating robots that resemble cuddly pets +and children, but their designers are careful not to make their robots +appear too human, which can be unnerving. This phenomenon was first +studied by Dr. Masahiro Mori in Japan in 1970, and is called the +“uncanny valley.” It posits that robots look creepy if they look too much +like humans. (The effect was actually first mentioned by Darwin in 1839 +in The Voyage of the Beagle and again by Freud in 1919 in an essay titled +“The Uncanny.”) Since then, it has been studied very carefully not just +by AI researchers but also by animators, advertisers, and anyone +promoting a product involving humanlike figures. For instance, in a +review of the movie The Polar Express, a CNN writer noted, “Those +human characters in the film come across as downright ... well, creepy. +So The Polar Express is at best disconcerting, and at worst, a wee bit +horrifying.”" +"According to Dr. Mori, the more a robot looks like a human, the more +we feel empathy toward it, but only up to a point. There is a dip in +empathy as the robot approaches actual human appearance—hence the +uncanny valley. If the robot looks very similar to us save for a few +features that are “uncanny,” it creates a feeling of revulsion and fear. If +the robot appears 100 percent human, indistinguishable from you and +me, then we’ll register positive emotions again. + +This has practical implications. For example, should robots smile? At +first, it seems obvious that robots should smile to greet people and make" +"them feel comfortable. Smiling is a universal gesture that signals warmth +and welcome. But if the robot smile is too realistic, it makes people’s +skin crawl. (For example, Halloween masks often feature fiendish- +looking ghouls that are grinning.) So robots should smile only if they are +childlike (i.e., with big eyes and a round face) or are perfectly human, +and nothing in between. (When we force a smile, we activate facial +muscles with our prefrontal cortex. But when we smile because we are in +a good mood, our nerves are controlled by our limbic system, which +activates a slightly different set of muscles. Our brains can tell the subtle +difference between the two, which was beneficial for our evolution.) + +This effect can also be studied using brain scans. Let’s say that a +subject is placed into an MRI machine and is shown a picture of a robot +that looks perfectly human, except that its bodily motions are slightly +jerky and mechanical. The brain, whenever it sees anything, tries to" +"predict that object’s motion into the future. So when looking at a robot +that appears to be human, the brain predicts that it will move like a +human. But when the robot moves like a machine, there is a mismatch, +which makes us uncomfortable. In particular, the parietal lobe lights up +(specifically, the part of the lobe where the motor cortex connects with +the visual cortex). It is believed that mirror neurons exist in this area of +the parietal lobe. This makes sense, because the visual cortex picks up +the image of the humanlike robot, and its motions are predicted via the +motor cortex and by mirror neurons. Finally, it is likely that the +orbitofrontal cortex, located right behind the eyes, puts everything +together and says, “Hmmm, something is not quite right.”" +"Hollywood filmmakers are aware of this effect. When spending +millions on making a horror movie, they realize that the scariest scene is +not when a gigantic blob or Frankenstein’s monster pounces out of the +bushes. The scariest scene is when there is a perversion of the ordinary. +Think of the movie The Exorcist What scene made moviegoers vomit as +they ran to escape the theater or faint right in their seats? Was it the +scene when a demon appears? No. Theaters across the world erupted in +shrill screams and loud sobs when Linda Blair turned her head +completely around." +"This effect can also be demonstrated in young monkeys. If you show +them pictures of Dracula or Frankenstein, they simply laugh and rip the +pictures apart. But what sends these young monkeys screaming in terror +is a picture of a decapitated monkey. Once again, it is the perversion of +the ordinary that elicits the greatest fear. (In Chapter 2, we mentioned +that the space-time theory of consciousness explains the nature of +humor, since the brain simulates the future of a joke, and then is +surprised to hear the punch line. This also explains the nature of horror. +The brain simulates the future of an ordinary, mundane event, but then + + is shocked when things suddenly become horribly perverted.) + +For this reason, robots will continue to look somewhat childlike in +appearance, even as they approach human intelligence. Only when +robots can act realistically like humans will their designers make them +look fully human. + +SILICON CONSCIOUSNESS" +"SILICON CONSCIOUSNESS + +As we’ve seen, human consciousness is an imperfect patchwork of +different abilities developed over millions of years of evolution. Given +information about their physical and social world, robots may be able to +create simulations similar (or in some respects, even superior) to ours, +but silicon consciousness might differ from ours in two key areas: +emotions and goals. + +Historically, AI researchers ignored the problem of emotions, +considering it a secondary issue. The goal was to create a robot that was +logical and rational, not scatterbrained and impulsive. Hence, the +science fiction of the 1950s and ’60s stressed robots (and humanoids like +Spock on Star Trek ) that had perfect, logical brains." +"We saw with the uncanny valley that robots will have to look a certain +way if they’re to enter our homes, but some people argue that robots +must also have emotions so that we can bond with, take care of, and +interact productively with them. In other words, robots will need Level II +consciousness. To accomplish this, robots will first have to recognize the +full spectrum of human emotions. By analyzing subtle facial movements +of the eyebrows, eyelids, lips, cheeks, etc., a robot will be able to +identify the emotional state of a human, such as its owner. One +institution that has excelled in creating robots that recognize and mimic +emotion is the MIT Media Laboratory. I have had the pleasure of visiting +the laboratory, outside Boston, on several occasions, and it is like +visiting a toy factory for grown-ups. Everywhere you look, you see +futuristic, high-tech devices designed to make our lives more interesting, +enjoyable, and convenient." +"As I looked around the room, I saw many of the high-tech graphics +that eventually found their way into Hollywood movies like Minority +Report and AI. As I wandered through this playground of the future, I +came across two intriguing robots, Huggable and Nexi. Their creator, Dr. +Cynthia Breazeal, explained to me that these robots have specific goals. +Huggable is a cute teddy bear-like robot that can bond with children. It +can identify the emotions of children; it has video cameras for eyes, a +speaker for its mouth, and sensors in its skin (so it can tell when it is +being tickled, poked, or hugged). Eventually, a robot like this might +become a tutor, babysitter, nurse’s aide, or a playmate. + + Nexi, on the other hand, can bond with adults. It looks a little like the +Pillsbury Doughboy. It has a round, puffy, friendly face, with large eyes" +"that can roll around. It has already been tested in a nursing home, and +the elderly patients all loved it. Once the seniors got accustomed to Nexi, +they would kiss it, talk to it, and miss it when it had to leave. (See +Figure 12.) + +Dr. Breazeal told me she designed Huggable and Nexi because she was +not satisfied with earlier robots, which looked like tin cans full of wires, +gears, and motors. In order to design a robot that could interact +emotionally with people, she needed to figure out how she could get it +to perform and bond like us. Plus, she wanted robots that weren’t stuck +on a laboratory shelf but could venture out into the real world. The +former director of MIT’s Media Lab, Dr. Frank Moss, says, “That is why +Breazeal decided in 2004 that it was time to create a new generation of +social robots that could live anywhere: homes, schools, hospitals, elder +care facilities, and so on.”" +"At Waseda University in Japan, scientists are working on a robot that +has upper-body motions representing emotions (fear, anger, surprise, +joy, disgust, sadness) and can hear, smell, see, and touch. It has been +programmed to carry out simple goals, such as satisfying its hunger for +energy and avoiding dangerous situations. Their goal is to integrate the +senses with the emotions, so that the robot acts appropriately in +different situations. + +Figure 12. Huggable (top) and Nexi (bottom), two robots built at the MIT Media Laboratory that were +explicitly designed + +to interact with humans via emotions, (illustration credit 10.1) + +(illustration credit 10.2) + +Not to be outdone, the European Commission is funding an ongoing +project, called Feelix Growing, which seeks to promote artificial +intelligence in the UK, France, Switzerland, Greece, and Denmark. + +EMOTIONAL ROBOTS + + Meet Nao." +"EMOTIONAL ROBOTS + + Meet Nao. + +When he’s happy, he will stretch out his arms to greet you, wanting a +big hug. When he’s sad, he turns his head downward and appears +forlorn, with his shoulders hunched forward. When he’s scared, he +cowers in fear, until someone pats him reassuringly on the head. + +He’s just like a one-year-old boy, except that he’s a robot. Nao is about +one and a half feet tall, and looks very much like some of the robots you +see in a toy store, like the Tranformers, except he’s one of the most +advanced emotional robots on earth. He was built by scientists at the + +UK’s University of Hertfordshire, whose research was funded by the +European Union. + +His creators have programmed him to show emotions like happiness, +sadness, fear, excitement, and pride. While other robots have +rudimentary facial and verbal gestures that communicate their emotions, +Nao excels in body language, such as posture and gesture. Nao even +dances." +"Unlike other robots, which specialize in mastering just one area of the +emotions, Nao has mastered a wide range of emotional responses. First, +Nao locks onto visitors’ faces, identifies them, and remembers his +previous interactions with each of them. Second, he begins to follow +their movements. For example, he can follow their gaze and tell what +they are looking at. Third, he begins to bond with them and learns to +respond to their gestures. For example, if you smile at him, or pat him +on his head, he knows that this is a positive sign. Because his brain has +neural networks, he learns from interactions with humans. Fourth, Nao +exhibits emotions in response to his interactions with people. (His +emotional responses are all preprogrammed, like a tape recorder, but he +decides which emotion to choose to fit the situation.) And lastly, the +more Nao interacts with a human, the better he gets at understanding +the moods of that person and the stronger the bond becomes." +"Not only does Nao have a personality, he can actually have several of +them. Because he learns from his interactions with humans and each +interaction is unique, eventually different personalities begin to emerge. +For example, one personality might be quite independent, not requiring +much human guidance. Another personality might be timid and fearful, +scared of objects in a room, constantly requiring human intervention. + +The project leader for Nao is Dr. Lola Canamero, a computer scientist +at the University of Hertfordshire. To start this ambitious project, she +analyzed the interactions of chimpanzees. Her goal was to reproduce, as +closely as she could, the emotional behavior of a one-year-old + + chimpanzee." +"chimpanzee. + +She sees immediate applications for these emotional robots. Like Dr. +Breazeal, she wants to use these robots to relieve the anxiety of young +children who are in hospitals. She says, “We want to explore different +roles—the robots will help the children to understand their treatment, +explain what they have to do. We want to help the children to control + +their anxiety.” + +Another possibility is that the robots will become companions at +nursing homes. Nao could become a valuable addition to the staff of a +hospital. At some point, robots like these might become playmates to +children and a part of the family." +"“It’s hard to predict the future, but it won’t be too long before the +computer in front of you will be a social robot. You’ll be able to talk to +it, flirt with it, or even get angry and yell at it—and it will understand +you and your emotions,” says Dr. Terrence Sejnowski of the Salk +Institute, near San Diego. This is the easy part. The hard part is to gauge +the response of the robot, given this information. If the owner is angry +or displeased, the robot has to be able to factor this into its response. + +EMOTIONS: DETERMINING WHAT IS IMPORTANT" +"EMOTIONS: DETERMINING WHAT IS IMPORTANT + +What’s more, AI researchers have begun to realize that emotions may be +a key to consciousness. Neuroscientists like Dr. Antonio Damasio have +found that when the link between the prefrontal lobe (which governs +rational thought) and the emotional centers (e.g., the limbic system) is +damaged, patients cannot make value judgments. They are paralyzed +when making the simplest of decisions (what things to buy, when to set +an appointment, which color pen to use) because everything has the +same value to them. Hence, emotions are not a luxury; they are +absolutely essential, and without them a robot will have difficulty +determining what is important and what is not. So emotions, instead of +being peripheral to the progress of artificial intelligence, are now +assuming central importance." +"If a robot encounters a raging fire, it might rescue the computer files +first, not the people, since its programming might say that valuable +documents cannot be replaced but workers always can be. It is crucial +that robots be programmed to distinguish between what is important +and what is not, and emotions are shortcuts the brain uses to rapidly +determine this. Robots would thus have to be programmed to have a +value system—that human life is more important than material objects, + + that children should be rescued first in an emergency, that objects with a +higher price are more valuable than objects with a lower price, etc. Since + +robots do not come equipped with values, a huge list of value judgments +must be uploaded into them." +"The problem with emotions, however, is that they are sometimes +irrational, while robots are mathematically precise. So silicon +consciousness may differ from human consciousness in key ways. For +example, humans have little control over emotions, since they happen so +rapidly and because they originate in the limbic system, not the +prefrontal cortex of the brain. Furthermore, our emotions are often +biased. Numerous tests have shown that we tend to overestimate the +abilities of people who are handsome or pretty. Good-looking people +tend to rise higher in society and have better jobs, although they may +not be as talented as others. As the expression goes, “Beauty has its +privileges.”" +"Similarly, silicon consciousness may not take into account subtle cues +that humans use when they meet one another, such as body language. +When people enter a room, young people usually defer to older ones and +low-ranked staff members show extra courtesy to senior officials. We +show our deference in the way we move our bodies, our choice of words, +and our gestures. Because body language is older than language itself, it +is hardwired into the brain in subtle ways. Robots, if they are to interact +socially with people, will have to learn these unconscious cues. + +Our consciousness is influenced by peculiarities in our evolutionary +past, which robots will not have, so silicon consciousness may not have +the same gaps or quirks as ours. + +A MENU OF EMOTIONS + +Since emotions have to be programmed into robots from the outside, +manufacturers may offer a menu of emotions carefully chosen on the +basis of whether they are necessary, useful, or will increase bonding +with the owner." +"In all likelihood, robots will be programmed to have only a few +human emotions, depending on the situation. Perhaps the emotion most +valued by the robot’s owner will be loyalty. One wants a robot that +faithfully carries out its commands without complaints, that understands +the needs of the master and anticipates them. The last thing an owner + + will want is a robot with an attitude, one that talks back, criticizes +people, and whines. Helpful criticisms are important, but they must be +made in a constructive, tactful way. Also, if humans give it conflicting +commands, the robot should know to ignore all of them except those +coming from its owner. + +Empathy will be another emotion that will be valued by the owner. +Robots that have empathy will understand the problems of others and +will come to their aid. By interpreting facial movements and listening to +tone of voice, robots will be able to identify when a person is in distress +and will provide assistance when possible." +"Strangely, fear is another emotion that is desirable. Evolution gave us +the feeling of fear for a reason, to avoid certain things that are +dangerous to us. Even though robots will be made of steel, they should +fear certain things that can damage them, like falling off tall buildings or +entering a raging fire. A totally fearless robot is a useless one if it +destroys itself. + +But certain emotions may have to be deleted, forbidden, or highly +regulated, such as anger. Given that robots could be built to have great +physical strength, an angry robot could create tremendous problems in +the home and workplace. Anger could get in the way of its duties and +cause great damage to property. (The original evolutionary purpose of +anger was to show our dissatisfaction. This can be done in a rational, +dispassionate way, without getting angry.)" +"Another emotion that should be deleted is the desire to be in +command. A bossy robot will only make trouble and might challenge the +judgment and wishes of the owner. (This point will also be important +later, when we discuss whether robots will one day take over from +humans.) Hence the robot will have to defer to the wishes of the owner, +even if this may not be the best path. + +But perhaps the most difficult emotion to convey is humor, which is a +glue that can bond total strangers together. A simple joke can defuse a +tense situation or inflame it. The basic mechanics of humor are simple: +they involve a punch line that is unanticipated. But the subtleties of +humor can be enormous. In fact, we often size up other people on the +basis of how they react to certain jokes. If humans use humor as a gauge +to measure other humans, then one can appreciate the difficulty of +creating a robot that can tell if a joke is funny or not. President Ronald" +"Reagan, for example, was famous for defusing the most difficult +questions with a quip. In fact, he accumulated a large card catalog of +jokes, barbs, and wisecracks, because he understood the power of + + humor. (Some pundits concluded that he won the presidential debate +against Walter Mondale when he was asked if he was too old to be +president. Reagan replied that he would not hold the youth of his +opponent against him.) Also, laughing inappropriately could have +disastrous consequences (and is, in fact, sometimes a sign of mental +illness). The robot has to know the difference between laughing with or +at someone. (Actors are well aware of the diverse nature of laughter. +They are skilled enough to create laughter that can represent horror, +cynicism, joy, anger, sadness, etc.) So, at least until the theory of +artificial intelligence becomes more developed, robots should stay away +from humor and laughter. + +PROGRAMMING EMOTIONS" +"PROGRAMMING EMOTIONS + +In this discussion we have so far avoided the difficult question of +precisely how these emotions would be programmed into a computer. +Because of their complexity, emotions will probably have to be +programmed in stages. + +First, the easiest part is identifying an emotion by analyzing the +gestures in a person’s face, lips, eyebrows, and tone of voice. Today’s +facial recognition technology is already capable of creating a dictionary +of emotions, so that certain facial expressions mean certain things. This +process actually goes back to Charles Darwin, who spent a considerable +amount of time cataloging emotions common to animals and humans. + +Second, the robot must respond rapidly to this emotion. This is also +easy. If someone is laughing, the robot will grin. If someone is angry, the +robot will get out of his way and avoid conflict. The robot would have a +large encyclopedia of emotions programmed into it, and hence would +know how to make a rapid response to each one." +"The third stage is perhaps the most complex because it involves trying +to determine the underlying motivation behind the original emotion. +This is difficult, since a variety of situations can trigger a single emotion. +Laughter may mean that someone is happy, heard a joke, or watched + +someone fall. Or it might mean that a person is nervous, anxious, or +insulting someone. Likewise, if someone is screaming, there may be an +emergency, or perhaps someone is just reacting with joy and surprise. +Determining the reason behind an emotion is a skill that even humans +have difficulty with. To do this, the robot will have to list the various +possible reasons behind an emotion and try to determine the reason that +makes the most sense. This means trying to find a reason behind the +emotion that fits the data best." +"And fourth, once the robot has determined the origin of this emotion, +it has to make the appropriate response. This is also difficult, since there +are often several possible responses, and the wrong one may make the +situation worse. The robot already has, within its programming, a list of +possible responses to the original emotion. It has to calculate which one +will best serve the situation, which means simulating the future. + +WILL ROBOTS LIE? + +Normally, we might think of robots as being coldly analytical and +rational, always telling the truth. But once robots become integrated into +society, they will probably have to learn to lie or at least tactfully +restrain their comments." +"In our own lives, several times in a typical day we are confronted with +situations where we have to tell a white lie. If people ask us how they +look, we often dare not tell the truth. White lies, in fact, are like a grease +that makes society run smoothly. If we were suddenly forced to tell the +whole truth (like Jim Carrey in Liar Liar), we most likely would wind up +creating chaos and hurting people. People would be insulted if you told +them what they really looked like or how you really felt. Bosses would +fire you. Lovers would dump you. Friends would abandon you. Strangers +would slap you. Some thoughts are better kept confidential." +"In the same way, robots may have to learn how to lie or conceal the +truth, or else they might wind up offending people and being +decommissioned by their owners. At a party, if a robot tells the truth, it +could reflect badly on its owner and create an uproar. So if someone asks +for its opinion, it will have to learn how to be evasive, diplomatic, and +tactful. It must either dodge the question, change the subject, give + +platitudes for answers, reply with a question, or tell white lies (all things +that today’s chat-bots are increasingly good at). This means that the +robot has already been programmed to have a list of possible evasive +responses, and must choose the one that creates the fewest +complications." +"One of the few times that a robot would tell the entire truth would be +if asked a direct question by its owner, who understands that the answer +might be brutally honest. Perhaps the only other time when the robot +will tell the truth is when there is a police investigation and the absolute +truth is necessary. Other than that, robots will be able to freely lie or +conceal the whole truth to keep the wheels of society functioning. + + In other words, robots have to be socialized, just like teenagers. + +CAN ROBOTS FEEL PAIN? + +Robots, in general, will be assigned to do types of tasks that are dull, +dirty, and dangerous. There is no reason why robots can’t do repetitive +or dirty jobs indefinitely, since we wouldn’t program them to feel +boredom or disgust. The real problem emerges when robots are faced +with dangerous jobs. At that point, we might actually want to program +them to feel pain." +"We evolved the sense of pain because it helped us survive in a +dangerous environment. There is a genetic defect in which children are +born without the ability to feel pain. This is called congenital analgesia. +At first glance, this may seem to be a blessing, since these children do +not cry when they experience injury, but it is actually more of a curse. +Children with this affliction have serious problems, such as biting off +parts of their tongue, suffering severe skin burns, and cutting +themselves, often leading to amputations of their fingers. Pain alerts us +to danger, telling us when to move our hand away from the burning +stove or to stop running on a twisted ankle." +"At some point robots must be programmed to feel pain, or else they +will not know when to avoid precarious situations. The first sense of +pain they must have is hunger (i.e., a craving for electrical energy). As +their batteries run out, they will get more desperate and urgent, +realizing that soon their circuits will shut down, leaving all their work in + +disarray. The closer they are to running out of power, the more anxious +they will become. + +Also, regardless of how strong they are, robots may accidentally pick +up an object that is too heavy, which could cause their limbs to break. +Or they may suffer overheating by working with molten metal in a steel +factory, or by entering a burning building to help firemen. Sensors for +temperature and stress would alert them that their design specifications +are being exceeded." +"But once the sensation of pain is added to their menu of emotions, this +immediately raises ethical issues. Many people believe that we should +not inflict unnecessary pain on animals, and people may feel the same +about robots as well. This opens the door to robots’ rights. Laws may +have to be passed to restrict the amount of pain and danger that a robot +is allowed to face. People will not care if a robot is performing dull or +dirty tasks, but if they feel pain doing a dangerous one, they may begin + + to lobby for laws to protect robots. This may even start a legal conflict, +with owners and manufacturers of robots arguing for increasing the level +of pain that robots can endure, while ethicists may argue for lowering it." +"This, in turn, may set off other ethical debates about other robot +rights. Can robots own property? What happens if they accidentally hurt +someone? Can they be sued or punished? Who is responsible in a +lawsuit? Can a robot own another robot? This discussion raises another +sticky question: Should robots be given a sense of ethics? + +ETHICAL ROBOTS + +At first, the idea of ethical robots seems like a waste of time and effort. +However, this question takes on a sense of urgency when we realize that +robots will make life-and-death decisions. Since they will be physically +strong and have the capability of saving lives, they will have to make +split-second ethical choices about whom to save first." +"Let’s say there is a catastrophic earthquake and children are trapped in +a rapidly crumbling building. How should the robot allocate its energy? +Should it try to save the largest number of children? Or the youngest? Or +the most vulnerable? If the debris is too heavy, the robot may damage its +electronics. So the robot has to decide yet another ethical question: How + +does it weigh the number of children it saves versus the amount of +damage that it will sustain to its electronics? + +Without proper programming, the robot may simply halt, waiting for a +human to make the final decision, wasting valuable time. So someone +will have to program it ahead of time so that the robot automatically +makes the “right” decision." +"These ethical decisions will have to be preprogrammed into the +computer from the start, since there is no law of mathematics that can +put a value on saving a group of children. Within its programming, there +has to be a long list of things, ranked in terms of how important they +are. This is tedious business. In fact, it sometimes takes a human a +lifetime to learn these ethical lessons, but a robot has to learn them +rapidly, before it leaves the factory, if it is to safely enter society. + +Only people can do this, and even then ethical dilemmas sometimes +confound us. But this raises questions: Who will make the decisions? +Who decides the order in which robots save human lives? + +The question of how decisions will ultimately be made will probably" +"The question of how decisions will ultimately be made will probably + + be resolved via a combination of the law and the marketplace. Laws will +have to be passed so that there is, at minimum, a ranking of importance +of whom to save in an emergency. But beyond that, there are thousands +of finer ethical questions. These subtler decisions may be decided by the +marketplace and common sense. + +If you work for a security firm guarding important people, you will +have to tell the robot how to save people in a precise order in different +situations, based on considerations such as fulfilling the primary duty +but also doing it within budget." +"What happens if a criminal buys a robot and wants the robot to +commit a crime? This raises a question: Should a robot be allowed to +defy its owner if it is asked to break the law? We saw from the previous +example that robots must be programmed to understand the law and +also make ethical decisions. So if it decides that it is being asked to +break the law, it must be allowed to disobey its master. + +There is also the ethical dilemma posed by robots reflecting the beliefs +of their owners, who may have diverging morals and social norms. The +“culture wars” that we see in society today will only be magnified when +we have robots that reflect the opinions and beliefs of their owners. In +some sense, this conflict is inevitable. Robots are mechanical extensions + +of the dreams and wishes of their creators, and when robots are +sophisticated enough to make moral decisions, they will do so." +"The fault lines of society may be stressed when robots begin to exhibit +behaviors that challenge our values and goals. Robots owned by youth +leaving a noisy, raucus rock concert may conflict with robots owned by +elderly residents of a quiet neighborhood. The first set of robots may be +programmed to amplify the sounds of the latest bands, while the second +set may be programmed to keep noise levels to an absolute minimum. +Robots owned by devout, churchgoing fundamentalists may get into +arguments with robots owned by atheists. Robots from different nations +and cultures may be designed to reflect the mores of their society, which +may clash (even for humans, let alone robots). + +So how does one program robots to eliminate these conflicts?" +"So how does one program robots to eliminate these conflicts? + +You can’t. Robots will simply reflect the biases and prejudices of their +creators. Ultimately, the cultural and ethical differences between these +robots will have to be settled in the courts. There is no law of physics or +science that determines these moral questions, so eventually laws will +have to be written to handle these social conflicts. Robots cannot solve +the moral dilemmas created by humans. In fact, robots may amplify +them. + + But if robots can make ethical and legal decisions, can they also feel +and understand sensations? If they succeed in saving someone, can they +experience joy? Or can they even feel things like the color red? Coldly +analyzing the ethics of whom to save is one thing, but understanding +and feeling is another. So can robots feel? + +CAN ROBOTS UNDERSTAND OR FEEL?" +"CAN ROBOTS UNDERSTAND OR FEEL? + +Over the centuries, a great many theories have been advanced about +whether a machine can think and feel. My own philosophy is called +“constructivism”; that is, instead of endlessly debating the question, +which is pointless, we should be devoting our energy to creating an +automaton to see how far we can get. Otherwise we wind up in endless +philosophical debates that are never ultimately resolved. The advantage +of science is that, once everything is said and done, one can perform +experiments to settle a question decisively." +"Thus, to settle the question of whether a robot can think, the final +resolution may be to build one. Some, however, have argued that +machines will never be able to think like a human. Their strongest +argument is that, although a robot can manipulate facts faster than a +human, it does not “understand” what it is manipulating. Although it +can process senses (e.g., color, sound) better than a human, it cannot +truly “feel” or “experience” the essence of these senses. + +For example, philosopher David Chalmers has divided the problems of +AI into two categories, the Easy Problems and the Hard Problems. To +him, the Easy Problems are creating machines that can mimic more and +more human abilities, such as playing chess, adding numbers, +recognizing certain patterns, etc. The Hard Problems involve creating +machines that can understand feelings and subjective sensations, which +are called “qualia.”" +"Just as it is impossible to teach the meaning of the color red to a blind +person, a robot will never be able to experience the subjective sensation +of the color red, they say. Or a computer might be able to translate +Chinese words into English with great fluency, but it will never be able +to understand what it is translating. In this picture, robots are like +glorified tape recorders or adding machines, able to recite and +manipulate information with incredible precision, but without any +understanding whatsoever. + +These arguments have to be taken seriously, but there is also another +way of looking at the question of qualia and subjective experience. In" +"the future, a machine most likely will be able to process a sensation, +such as the color red, much better than any human. It will be able to +describe the physical properties of red and even use it poetically in a +sentence better than a human. Does the robot “feel” the color red? The +point becomes irrelevant, since the word “feel” is not well defined. At +some point, a robot’s description of the color red may exceed a human’s, +and the robot may rightly ask: Do humans really understand the color +red? Perhaps humans cannot really understand the color red with all the +nuances and subtly that a robot can. + +As behaviorist B. F. Skinner once said, “The real problem is not +whether machines think, but whether men do.” + +Similarly, it is only a matter of time before a robot will be able to +define Chinese words and use them in context much better than any" +"human. At that point, it becomes irrelevant whether the robot +“understands” the Chinese language. For all practical purposes, the +computer will know the Chinese language better than any human. In +other words, the word “understand” is not well defined. + +One day, as robots surpass our ability to manipulate these words and +sensations, it will become irrelevant whether the robot “understands” or +“feels” them. The question will cease to have any importance. + +As mathematician John von Neumann said, “In mathematics, you +don’t understand things. You just get used to them.” + +So the problem lies not in the hardware but in the nature of human +language, in which words that are not well defined mean different things +to different people. The great quantum physicist Niels Bohr was once +asked how one could understand the deep paradoxes of the quantum +theory. The answer, he replied, lies in how you define the word +“understand.”" +"Dr. Daniel Dennett, a philosopher at Tufts University, has written, +“There could not be an objective test to distinguish a clever robot from a +conscious person. Now you have a choice: you can either cling to the +Hard Problem, or you can shake your head in wonder and dismiss it. +Just let go.” + +In other words, there is no such thing as the Hard Problem. + +To the constructivist philosophy, the point is not to debate whether a +machine can experience the color red, but to construct the machine. In +this picture, there is a continuum of levels describing the words +“understand” and “feel.” (This means that it might even be possible to" +"give numerical values to the degree of understanding and feeling.) At +one end we have the clumsy robots of today, which can manipulate a +few symbols but not much more. At the other end we have humans, who +pride themselves on feeling qualia. But as time goes by, robots will +eventually be able to describe sensations better than us on any level. +Then it will be obvious that robots understand. + +This was the philosophy behind Alan Turing’s famous Turing test. He +predicted that one day a machine would be built that could answer any +question, so that it would be indistinguishable from a human. He said, +“A computer would deserve to be called intelligent if it could deceive a +human into believing that it was human.” + +Physicist and Nobel laureate Francis Crick said it best. In the last" +"Physicist and Nobel laureate Francis Crick said it best. In the last + +century, he noted, biologists had heated debates over the question “What +is life?” Now, with our understanding of DNA, scientists realize that the +question is not well defined. There are many variations, layers, and +complexities to that simple question. The question “What is life?” simply +faded away. The same may eventually apply to feeling and +understanding. + +SELF-AWARE ROBOTS + +What steps must be taken before computers like Watson have self- +awareness? To answer this question, we have to refer back to our +definition of self-awareness: the ability to put one’s self inside a model of +the environment, and then run simulations of this model into the future +to achieve a goal. This first step requires a very high level of common +sense in order to anticipate a variety of events. Then the robot has to put +itself inside this model, which requires an understanding of the various +courses of action it may take." +"At Meiji University, scientists have taken the first steps to create a +robot with self-awareness. This is a tall order, but they think they can do +it by creating robots with a Theory of Mind. They started by building +two robots. The first was programmed to execute certain motions. The +second was programmed to observe the first robot, and then to copy it. +They were able to create a second robot that could systematically mimic +the behavior of the first just by watching it. This is the first time in +history that a robot has been built specifically to have some sense of self- +awareness. The second robot has a Theory of Mind; that is, it is capable +of watching another robot and then mimicking its motions. + +In 2012, the next step was taken by scientists at Yale University who" +"In 2012, the next step was taken by scientists at Yale University who + + created a robot that passed the mirror test. When animals are placed in +front of a mirror, most of them think the image in the mirror is that of +another animal. As we recall, only a few animals have passed the mirror +test, realizing that the mirror image was a reflection of themselves. The +scientists at Yale created a robot called Nico that resembles a gangly +skeleton made of twisted wires, with mechanical arms and two bulging +eyes sitting on top. When placed in front of a mirror, Nico not only +recognized itself but could also deduce the location of objects in a room + +by looking at their images in the mirror. This is similar to what we do +when we look into a rearview mirror and infer the location of objects +behind us." +"Nico’s programmer, Justin Hart, says, “To our knowledge, this is the +first robotic system to attempt to use a mirror in this way, representing a +significant step towards a cohesive architecture that allows robots to +learn about their bodies and appearance through self-observation, and +an important capability required in order to pass the mirror test.” + +Because the robots at Meiji University and Yale University represent +the state of the art in terms of building robots with self-awareness, it is +easy to see that scientists have a long ways to go before they can create +robots with humanlike self-awareness. + +Their work is just the first step, because our definition of self- +awareness demands that the robot use this information to create +simulations of the future. This is far beyond the capability of Nico or any +other robot." +"This raises the important question: How can a computer gain full self- +awareness? In science fiction, we often encounter a situation where the +Internet suddenly becomes self-aware, as in the movie The Terminator. +Since the Internet is connected to the entire infrastructure of modern +society (e.g., our sewer system, our electricity, our telecommunications, +our weapons), it would be easy for a self-aware Internet to seize control +of society. We would be left helpless in this situation. Scientists have +written that this may happen as an example of an “emergent +phenomenon” (i.e., when you amass a sufficiently large number of +computers together, there can be a sudden phase transition to a higher +stage, without any input from the outside). + +However, this says everything and it says nothing, because it leaves +out all the important steps in between. It’s like saying that a highway +can suddenly become self-aware if there are enough roads." +"But in this book we have given a definition of consciousness and self- +awareness, so it should be possible to list the steps by which the Internet + + can become self-aware. + +First, an intelligent Internet would have to continually make models of +its place in the world. In principle, this information can be programmed +into the Internet from the outside. This would involve describing the +outside world (i.e., Earth, its cities, and its computers), all of which can + +be found on the Internet itself. + +Second, it would have to place itself in the model. This information is +also easily obtained. It would involve giving all the specifications of the +Internet (the number of computers, nodes, transmission lines, etc.) and +its relationship to the outside world." +"But step three is by far the most difficult. It means continually running +simulations of this model into the future, consistent with a goal. This is +where we hit a brick wall. The Internet is not capable of running +simulations into the future, and it has no goals. Even in the scientific +world, simulations into the future are usually done in just a few +parameters (e.g., simulating the collision of two black holes). Running a +simulation of the model of the world containing the Internet is far +beyond the programming available today. It would have to incorporate +all the laws of common sense, all the laws of physics, chemistry, and +biology, as well as facts about human behavior and human society. + +In addition, this intelligent Internet would have to have a goal. Today +it is just a passive highway, without any direction or purpose. Of course, +one can in principle impose a goal on the Internet. But let us consider +the following problem: Can you create an Internet whose goal is self- +preservation?" +"This would be the simplest possible goal, but no one knows how to +program even this simple task. Such a program, for example, would have +to stop any attempt to shut down the Internet by pulling the plug. At +present, the Internet is totally incapable of recognizing a threat to its +existence, let alone plotting ways to prevent it. (For example, an Internet +capable of detecting threats to its existence would have to be able to +identify attempts to shut down its power, cut lines of communication, +destroy its servers, disable its fiber-optic and satellite connections, etc. +Furthermore, an Internet capable of defending itself against these attacks +would have to have countermeasures for each scenario and then run +these attempts into the future. No computer on Earth is capable of doing +even a fraction of such things.) + +In other words, one day it may be possible to create self-aware robots, +even a self-aware Internet, but that day is far into the future, perhaps at +the end of this century." +"But assume for the moment that the day has arrived, that self-aware +robots walk among us. If a self-aware robot has goals that are + +compatible with our own, then this type of artificial intelligence will not +pose a problem. But what happens if the goals are different? The fear is +that humans may be outwitted by self-aware robots and then may be +enslaved. Because of their superior ability to simulate the future, the +robots could plot the outcomes of many scenarios to find the best way to +overthrow humanity. + +One way this possibility may be controlled is to make sure that the +goals of these robots are benevolent. As we have seen, simulating the +future is not enough. These simulations must serve some final goal. If a +robot’s goal is merely to preserve itself, then it would react defensively +to any attempt to pull the plug, which could spell trouble for mankind. + +WILL ROBOTS TAKE OVER?" +"WILL ROBOTS TAKE OVER? + +In almost all science-fiction tales, the robots become dangerous because +of their desire to take over. The word “robot,” in fact, comes from the +Czech word for “worker,” first seen in the 1920 play R.U.R. (Rossum’s +Universal Robots) by Karel Capek, in which scientists create a new race of +mechanical beings that look identical to humans. Soon there are +thousands of these robots performing menial and dangerous tasks. +However, humans mistreat them badly, and one day they rebel and +destroy the human race. Although these robots have taken over Earth, +they have one defect: they cannot reproduce. But at the end of the play, +two robots fall in love. So perhaps a new branch of “humanity” emerges +once again." +"A more realistic scenario comes from the movie The Terminator, in +which the military has created a supercomputer network called Skynet +that controls the entire U.S. nuclear stockpile. One day, it wakes up and +becomes sentient. The military tries to shut down Skynet but then +realizes there is a flaw in its programming: it is designed to protect itself, +and the only way to do so is by eliminating the problem—humanity. It +starts a nuclear war, which reduces humanity to a ragtag bunch of +misfits and rebels fighting the juggernaut of the machines. + +It is certainly possible that robots could become a threat. The current +Predator drone can target its victims with deadly accuracy, but it is +controlled by someone with a joystick thousands of miles away." +"According to the New York Times, the orders to fire come directly from +the president of the United States. But in the future, a Predator might +have face recognition technology and permission to fire if it is 99 +percent confident of the identity of its target. Without human +intervention, it could automatically use this technology to fire at anyone +who fits the profile. + +Now assume that such a drone suffers a breakdown, such that its facial +recognition software malfunctions. Then it becomes a rogue robot, with +permission to kill anyone in sight. Worse, imagine a fleet of such robots +controlled by a central command. If a single transistor were to blow out +in this central computer and malfunction, then the entire fleet might go +on a killing spree." +"A more subtle problem is when robots perform perfectly well, without +any malfunctions, yet there is a tiny but fatal flaw in their programming +and goals. For a robot, self-preservation is one important goal. But so is +being helpful to humans. The real problem arises when these goals +contradict each other. + +In the movie 1 , Robot, the computer system decides that humans are +self-destructive, with their never-ending wars and atrocities, and that the +only way to protect the human race is to take over and create a +benevolent dictatorship of the machine. The contradiction here is not +between two goals, but within a single goal that is not realistic. These +murderous robots do not malfunction—they logically conclude that the +only way to preserve humanity is to take control of society." +"One solution to this problem is to create a hierarchy of goals. For +example, the desire to help humans must outrank self-preservation. This +theme was explored in the movie 2001 . The computer system HAL 9000 +was a sentient computer capable of conversing easily with humans. But +the orders given to HAL 9000 were self-contradictory and could not be +logically carried out. By attempting to execute an impossible goal, it fell +off the mesa; it went crazy, and the only solution to obeying +contradictory commands from imperfect humans was to eliminate the +humans. + +The best solution might be to create a new law of robotics, which +would state that robots cannot do harm to the human race, even if there +are contradictions within their previous directives. They must be +programmed to ignore lower-level contradictions within their orders and" +"always preserve the supreme law. But this might still be an imperfect +system at best. (For example, if the robots’ central goal is to protect +humanity to the exclusion of all other goals, then it all depends on how + + the robots define the word “protect.” Their mechanical definition of this +word may differ from ours.) + +Instead of reacting with terror, some scientists, such as Dr. Douglas +Hofstadter, a cognitive scientist at Indiana University, do not fear this +possibility. When I interviewed him, he told me that robots are our +children, so why shouldn’t we love them like our own? His attitude, he +told me, is that we love our children, even though we know that they +will take over." +"When I interviewed Dr. Hans Moravec, former director of the AI +Laboratory at Carnegie Mellon University, he agreed with Dr. Hofstadter. +In his book Robot, he writes, “Unleashed from the plodding pace of +biological evolution, the children of our minds will be free to grow to +confront immense and fundamental challenges in the larger universe. +... We humans will benefit for a time from their labors, but ... like +natural children, they will seek their own fortunes, while we, their aged +parents, silently fade away.” + +Others, on the contrary, think that this is a horrible solution. Perhaps +the problem can be solved if we make changes in our goals and priorities +now, before it is too late. Since these robots are our children, we should +“teach” them to be benevolent. + +FRIENDLY AI" +"FRIENDLY AI + +Robots are mechanical creatures that we make in the laboratory, so +whether we have killer robots or friendly robots depends on the +direction of AI research. Much of the funding comes from the military, +which is specifically mandated to win wars, so killer robots are a definite +possibility. + +However, since 30 percent of all commercial robots are manufactured +in Japan, there is another possibility: robots will be designed to become +helpful playmates and workers from the very beginning. This goal is +feasible if the consumer sector dominates robotics research. The +philosophy of “friendly AI” is that inventors should create robots that, + +from the very first steps, are programmed to be beneficial to humans." +"from the very first steps, are programmed to be beneficial to humans. + +Culturally, the Japanese approach to robots is different from the +West’s. While kids in the West might feel terror watching rampaging +Terminatortype robots, kids in Japan are steeped in the Shinto religion, +which believes spirits live in all things, even mechanical robots. Instead +of being uncomfortable at the sight of robots, Japanese children squeal" +"with delight upon encountering them. It’s no wonder, therefore, that +these robots in Japan are proliferating in the marketplace and in homes. +They greet you at department stores and educate you on TV. There is +even a serious play in Japan featuring a robot. (Japan has another +reason for embracing robots. These are the future robot nurses for an +aging country. Twenty-one percent of the population is over sixty-five, +and Japan is aging faster than any other nation. In some sense, Japan is +a train wreck in slow motion. Three demographic factors are at work. +First, Japanese women have the longest life expectancy of any ethnic +group in the world. Second, Japan has one of the world’s lowest +birthrates. Third, it has a strict immigration policy, with over 99 percent +of the population being pure Japanese. Without young immigrants to +take care of the elderly, Japan may rely on robot nurses. This problem is +not restricted to Japan; Europe is next. Italy, Germany, Switzerland, and" +"not restricted to Japan; Europe is next. Italy, Germany, Switzerland, and +other European nations face similar demographic pressures. The +populations of Japan and Europe could experience severe shrinkage by +mid-century. The United States is not far behind. The birthrate of native- +born U.S. citizens has also fallen dramatically in the last few decades, +but immigration will keep the United States expanding into this century. +In other words, it could be a trilliondollar gamble to see if robots can +save us from these three demographic nightmares.)" +"Japan leads the world in creating robots that can enter our personal +lives. The Japanese have built robots that can cook (one can make a +bowl of noodles in a minute and forty seconds). When you go to a +restaurant, you can place your order on a tablet computer and the robot +cook springs into action. It consists of two large, mechanical arms, which +grab the bowls, spoons, and knives and prepare the food for you. Some +robotic cooks even resemble human ones. + +There are also musical robots for entertainment. One such robot +actually has accordion-like “lungs” by which it can generate music by +pumping air through an instrument. There are also robot maids. If you" +"carefully prepare your laundry, it can fold it in front of you. There is +even a robot that can talk because it has artificial lungs, lips, tongue, +and nasal cavity. The Sony Corporation, for example, built the AIBO +robot, which resembles a dog and can register a number of emotions if +you pet it. Some futurists predict that the robotics industry may one day +become as large as the automobile industry is today. + +The point here is that robots are not necessarily programmed to +destroy and dominate. The future of AI is up to us. + +But some critics of friendly AI claim that robots may take over not +because they are aggressive, but because we are sloppy in creating them. +In other words, if the robots take over, it will be because we + + programmed them to have conflicting goals. + +“I AM A MACHINE”" +"programmed them to have conflicting goals. + +“I AM A MACHINE” + +When I interviewed Dr. Rodney Brooks, former director of the MIT +Artificial Intelligence Lab and cofounder of iRobot, I asked him if he +thought machines would one day take over. He told me that we just +have to accept that we are machines ourselves. This means that one day, +we will be able to build machines that are just as alive as we are. But, he +cautioned, we will have to give up the concept of our “specialness.” + +This evolution in human perspective started with Nicolaus Copernicus +when he realized that the Earth was not the center of the universe, but +rather goes around the sun. It continued with Darwin, who showed that +we were similar to the animals in our evolution. And it will continue +into the future, he told me, when we realize that we are machines, +except that we are made of wetware and not hardware." +"It’s going to represent a major change in our world outlook to accept +that we, too, are machines, he believes. He writes, “We don’t like to give +up our specialness, so you know, having the idea that robots could really +have emotions, or that robots could be living creatures—I think is going +to be hard for us to accept. But we’re going to come to accept it over the +next fifty years.” + +But on the question of whether the robots will eventually take over, he +says that this will probably not happen, for a variety of reasons. First, no +one is going to accidentally build a robot that wants to rule the world. + +He says that creating a robot that can suddenly take over is like someone +accidentally building a 747 jetliner. Plus, there will be plenty of time to +stop this from happening. Before someone builds a “super-bad robot,” +someone has to build a “mildly bad robot,” and before that a “not-so-bad +robot.”" +"His philosophy is summed up when he says, “The robots are coming, +but we don’t have too much to worry about. It’s going to be a lot of fun.” +To him, the robot revolution is a certainty, and he foresees the day when +robots will surpass human intelligence. The only question is when. But +there is nothing to fear, since we will have created them. We have the +choice to create them to help, and not hinder, us. + +MERGE WITH THEM? + + If you ask Dr. Brooks how we can coexist with these super-smart robots, +his reply is straightforward: we will merge with them. With advances in +robotics and neuroprosthetics, it becomes possible to incorporate AI into +our own bodies. + +Dr. Brooks notes that the process, in some sense, has already begun. +Today, about twenty thousand people have had cochlear implants, +which have given them the gift of hearing. Sounds are picked up by a +tiny receiver, which converts sound waves to electrical signals, which +are then sent directly to the auditory nerves of the ear." +"Similarly, at the University of Southern California and elsewhere, it is +possible to take a patient who is blind and implant an artificial retina. +One method places a mini video camera in eyeglasses, which converts an +image into digital signals. These are sent wirelessly to a chip placed in +the person’s retina. The chip activates the retina’s nerves, which then +send messages down the optic nerve to the occipital lobe of the brain. In +this way, a person who is totally blind can see a rough image of familiar +objects. Another design has a light-sensitive chip placed on the retina +itself, which then sends signals directly to the optic nerve. This design +does not need an external camera. + +This also means that we can go even further and enhance ordinary +senses and abilities. With cochlear implants, it will be possible to hear +high frequencies that we have never heard before. Already with infrared" +"glasses, one can see the specific type of light that emanates from hot +objects in the dark and that is normally invisible to the human eye. With +artificial retinas, it may be possible to enhance our ability to see +ultraviolet or infrared light. (Bees, for example, can see UV light because +they have to lock onto the sun in order to navigate to a flower bed.) + +Some scientists even dream of the day when exoskeletons will have +superpowers like those found in comic books, with super strength, super +senses, and super abilities. We’d become a cyborg like Iron Man, a +normal human with superhuman abilities and powers. This means that +we might not have to worry about super-intelligent robots taking over. +We’d simply merge with them." +"This, of course, is for the distant future. But some scientists, frustrated +that robots are not leaving the factory and entering our lives, point out +that Mother Nature has already created the human mind, so why not +copy it? Their strategy is to take the brain apart, neuron by neuron, and +then reassemble it. + +But reverse engineering entails more than just creating a vast + + blueprint to create a living brain. If the brain can be duplicated down to +the last neuron, perhaps we can upload our consciousness into a +computer. We’d have the ability to leave our mortal bodies behind. This +is beyond mind over matter. This is mind without matter. + +I’m as fond of my body as anyone, but if I can be 200 with a +body of silicon, I’ll take it. + +—DANIEL HILL, COFOUNDER OF THINKING MACHINES CORP. + +11 REVERSE ENGINEERING THE BRAIN" +"—DANIEL HILL, COFOUNDER OF THINKING MACHINES CORP. + +11 REVERSE ENGINEERING THE BRAIN + +In January 2013, two bombshells were dropped that could alter the +medical and scientific landscape forever. Overnight, reverse engineering +the brain, once considered to be too complex to solve, suddenly became +a focal point of scientific rivalry and pride between the greatest +economic powers on Earth." +"First, in his State of the Union address, President Barack Obama +stunned the scientific community by announcing that federal research +funds, perhaps to the tune of $3 billion, might be allocated to the Brain +Research Through Advancing Innovative Neurotechnologies (or BRAIN) +Initiative. Like the Human Genome Project, which opened the floodgates +for genetic research, BRAIN will pry open the secrets of the brain at the +neural level by mapping its electrical pathways. Once the brain is +mapped, a host of intractable diseases like Alzheimer’s, Parkinson’s, +schizophrenia, dementia, and bipolar disorder might be understood and +possibly cured. To jump-start BRAIN, $100 million might be allocated in +2014 toward the project." +"Almost simultaneously, the European Commission announced that the +Human Brain Project would be awarded 1.19 billion euros (about $1.6 +billion) to create a computer simulation of the human brain. Using the +power of the biggest supercomputers on the planet, the Human Brain +Project will create a copy of the human brain made of transistors and +steel. + +Proponents of both projects stressed the enormous benefits of these +endeavors. President Obama was quick to point out that not only would +BRAIN alleviate the suffering of millions of people, it will also generate +new revenue streams. For every dollar spent on the Human Genome +Project, he claimed, about $140 of economic activity was generated. +Entire industries, in fact, sprouted with the completion of the Human +Genome Project. For the taxpayer, BRAIN, like the Human Genome + + Project, will be a win-win situation." +"Project, will be a win-win situation. + +Although Obama’s speech did not give details, scientists quickly filled +in many of the gaps. Neurologists pointed out that, on one hand, it is +now possible to use delicate instruments to monitor the electrical +activity of single neurons. On the other hand, using MRI machines, it is +possible to monitor the global behavior of the entire brain. What is +missing, they pointed out, is the middle ground, where most of the +interesting brain activity takes place. It is in this middle ground, +involving the pathways of thousands to millions of neurons, that there +are huge gaps in our understanding of mental disease and behavior." +"To tackle this enormous problem, scientists laid out a tentative fifteen- +year program. In the first five years, neurologists hope to monitor the +electrical activity of tens of thousands of neurons. The short-term goals +might include reconstructing the electrical activity of important parts of +animal brains, such as the medulla of the Drosophila fruit fly or the +ganglion cells in a mouse retina (which has fifty thousand neurons). + +Within ten years, that number should increase to hundreds of +thousands of neurons. This could include imaging the entire Drosophila +brain (135,000 neurons) or even the cortex of the Etruscan shrew, the +smallest known mammal, with a million neurons. + +Finally, within fifteen years, it should be possible to monitor millions +of neurons, comparable to the zebrafish brain or the entire neocortex of +a mouse. This could pave the way toward imaging parts of the brains of +primates." +"Meanwhile, in Europe, the Human Brain Project would tackle the +problem from a different point of view. Over a ten-year period, it will +use supercomputers to simulate the basic functioning of the brains of +different animals, starting with mice and working up to humans. Instead +of dealing with individual neurons, the Human Brain Project will use +transistors to mimic their behavior, so that there will be computer +modules that can act like the neocortex, the thalamus, and other parts of +the brain. + +In the end, the rivalry between these two gigantic projects could +create a windfall by generating new discoveries for treating incurable +diseases and spawning new industries. But there is also another, unstated +goal. If one can eventually simulate a human brain, does it mean that +the brain can become immortal? Does it mean that consciousness can +now exist outside the body? Some of the thorniest theological and + + metaphysical questions are raised by these ambitious projects. + +BUILDING A BRAIN" +"metaphysical questions are raised by these ambitious projects. + +BUILDING A BRAIN + +Like many other children, I used to love taking apart clocks, +disassembling them, screw for screw, and then trying to see how the +whole thing fit together. I would trace each part mentally, seeing how +one gear connected to the next one, until the whole thing fit together. I +realized the mainspring turned the main gear, which then fed a sequence +of smaller gears, which eventually turned the hands of the clock. + +Today, on a much larger scale, computer scientists and neurologists +are trying to take apart an infinitely more complex object, the most +sophisticated object we know about in the universe: the human brain. +Moreover, they wish to reassemble it, neuron by neuron." +"Because of rapid advances in automation, robotics, nanotechnology, +and neuroscience, reverse engineering the human brain is no longer idle +speculation for polite after-dinner banter. In the United States and +Europe, billions of dollars will soon be flowing into projects once +considered preposterous. Today a small band of visionary scientists are +dedicating their professional lives to a project that they may not live to +see completed. Tomorrow their ranks could swell into an entire army, +generously funded by the United States and the nations of Europe. + +If successful, these scientists could alter the course of human history. +Not only might they find new cures and therapies for mental illnesses, +they might also unlock the secret of consciousness and perhaps upload it +into a computer." +"It is a daunting task. The human brain consists of over one hundred +billion neurons, approximately as many stars as there are in the Milky +Way galaxy. Each neuron, in turn, is connected to perhaps ten thousand +other neurons, so altogether there are a total of ten million billion +possible connections (and that does not begin to compute the number of +pathways there are among this thicket of neurons). The number of +“thoughts” that a human brain can conceive of is therefore truly +astronomical and beyond human ken. + +Yet that has not stopped a small bunch of fiercely dedicated scientists +from attempting to reconstruct the brain from scratch. There is an old + +Chinese proverb, “A journey of a thousand miles begins with the first +step.” That first step was actually taken when scientists decoded, neuron +for neuron, the nervous system of a nematode worm. This tiny creature," +"called C. elegans, has 302 neurons and 7,000 synapses, all of which have +been precisely recorded. A complete blueprint of its nervous system can +be found on the Internet. (Even today, it is the only living organism to +have its entire neural structure decoded in this way.) + +At first, it was thought that the complete reverse engineering of this +simple organism would open the door to the human brain. Ironically, the +opposite has happened. Although the nematode’s neurons were finite in +number, the network is still so complex and sophisticated that it has +taken years to understand even simple facts about worm behavior, such +as which pathways are responsible for which behaviors. If even the +lowly nematode worm could elude our scientific understanding, +scientists were forced to appreciate how complex a human brain must +be. + +THREE APPROACHES TO THE BRAIN" +"THREE APPROACHES TO THE BRAIN + +Because the brain is so complex, there are at least three distinct ways in +which it can be taken apart, neuron by neuron. The first is to simulate +the brain electronically with supercomputers, which is the approach +being taken by the Europeans. The second is to map out the neural +pathways of living brains, as in BRAIN. (This task, in turn, can be further +subdivided, depending on how these neurons are analyzed—either +anatomically, neuron by neuron, or by function and activity.) And third, +one can decipher the genes that control the development of the brain, +which is an approach pioneered by billionaire Paul Allen of Microsoft." +"The first approach, simulating the brain using transistors and +computers, is forging ahead by reverse engineering the brains of animals +in a certain sequence: first a mouse, then a rat, rabbit, and a cat. The +Europeans are following the rough trail of evolution, starting with +simple brains and working upward. To a computer scientist, the solution +is raw computing power—the more, the better. And this means using +some of the largest computers on Earth to decipher the brains of mice +and men." +"Their first target is the brain of a mouse, which is one-thousandth the +size of a human brain, containing about one hundred million neurons. +The thinking process behind a mouse brain is being analyzed by the IBM +Blue Gene computer, located at the Lawrence Livermore National +Laboratory in California, where some of the biggest computers in the +world are located; they’re used to design hydrogen warheads for the +Pentagon. This colossal collection of transistors, chips, and wires +contains 147,456 processors with a staggering 150,000 gigabytes of +memory. (A typical PC may have one processor and a few gigabytes of + + memory.) + +Progress has been slow but steady. Instead of modeling the entire +brain, scientists try to duplicate just the connections between the cortex +and the thalamus, where much of brain activity is concentrated. (This +means that the sensory connections to the outside world are missing in +this simulation.)" +"In 2006, Dr. Dharmendra Modha of IBM partially simulated the mouse +brain in this way with 512 processors. In 2007, his group simulated the +rat brain with 2,048 processors. In 2009, the cat brain, with 1.6 billion +neurons and nine trillion connections, was simulated with 24,576 +processors. + +Today, using the full power of the Blue Gene computer, IBM scientists +have simulated 4.5 percent of the human brain’s neurons and synapses. +To begin a partial simulation of the human brain, one would need +880,000 processors, which might be possible around 2020. + +I had a chance to film the Blue Gene computer. To get to the +laboratory, I had to go through layers and layers of security, since it is +the nation’s premier weapons laboratory, but once you have cleared all +the checkpoints, you enter a huge, air-conditioned room housing Blue +Gene." +"The computer is truly a magnificent piece of hardware. It consists of +racks and racks of large black cabinets full of switches and blinking +lights, each about eight feet tall and roughly fifteen feet long. As I +walked among the cabinets that make up Blue Gene, I wondered what +kinds of operations it was performing. Most likely, it was modeling the +interior of a proton, calculating the decay of plutonium triggers, +simulating the collision of two black holes, and thinking of a mouse, all +at once. + +Then I was told that even this supercomputer is giving way to the next +generation, the Blue Gene/Q Sequoia, which will take computing to a +new level. In June 2012, it set the world’s record for the fastest +supercomputer. At peak speed, it can perform operations at 20.1 PFLOPS +(or 20.1 trillion floating point operations per second). It covers an area +of three thousand square feet, and gobbles up electrical energy at the +rate of 7.9 megawatts, enough power to light up a small city." +"But with all this massive computational firepower concentrated in one +computer, is it enough to rival the human brain? + +Unfortunately, no. + + These computer simulations try only to duplicate the interactions +between the cortex and the thalamus. Huge chunks of the brain are +therefore missing. Dr. Modha understands the enormity of his project. +His ambitious research has allowed him to estimate what it would take +to create a working model of the entire human brain, and not just a +portion or a pale version of it, complete with all parts of the neocortex +and connections to the senses. He envisions using not just a single Blue +Gene computer but thousands of them, which would fill up not just a +room but an entire city block. The energy consumption would be so +great that you would need a thousand-megawatt nuclear power plant to +generate all the electricity. And then, to cool off this monstrous +computer so it wouldn’t melt, you would need to divert a river and send +it through the computer circuits." +"It is remarkable that a gigantic, city-size computer is required to +simulate a piece of human tissue that weighs three pounds, fits inside +your skull, raises your body temperature by only a few degrees, uses +twenty watts of power, and needs only a few hamburgers to keep it +going. + +BUILDING A BRAIN + +But perhaps the most ambitious scientist who has joined this campaign is +Dr. Henry Markram of the Ecole Polytechnique Federate de Lausanne, in +Switzerland. He is the driving force behind the Human Brain Project, +which has received over a billion dollars of funding from the European +Commission. He has spent the last seventeen years of his life trying to + +decode the brain’s neural wiring. He, too, is using the Blue Gene +computer to reverse engineer the brain. At present, his Human Brain +Project is running up a bill of $140 million from the European Union, +and that represents only a fraction of the computer firepower he will +need in the coming decade." +"Dr. Markram believes that this is no longer a science project but an +engineering endeavor, requiring vast sums of money. He says, “To build +this—the supercomputers, the software, the research—we need around +one billion dollars. This is not expensive when one considers that the +global burden of brain disease will exceed twenty percent of the world +gross domestic project very soon.” To him, a billion dollars is nothing, +just a pittance compared to the hundreds of billions in bills stemming +from Alzheimer’s, Parkinson’s, and other related diseases when the baby +boomers retire. + +So to Dr. Markram, the solution is one of scale. Throw enough money + + at the project, and the human brain will emerge. Now that he has won +the coveted billion-dollar prize from the European Commission, his +dream may become a reality." +"He has a ready answer when asked what the average taxpayer will get +from this billion-dollar investment. There are three reasons, he says, for +embarking on this lonely but expensive quest. First, “It’s essential for us +to understand the human brain if we want to get along in society, and I +think that it is a key step in evolution. The second reason is, we cannot +keep doing animal experimentation forever.... It’s like a Noah’s Ark. It’s +like an archive. And the third reason is that there are two billion people +on this planet that are affected by mental disorder....” + +To him, it is a scandal that so little is known about mental diseases, +which cause so much suffering to millions of people. He says, “There’s +not a single neurological disease today in which anybody knows what is +malfunctioning in this circuit—which pathway, which synapse, which +neuron, which receptor. This is shocking.”" +"At first, it may sound impossible to complete this project, with so +many neurons and so many connections. It seems like a fool’s errand. +But these scientists think they have an ace in the hole. + +The human genome consists of roughly twenty-three thousand genes, +yet it can somehow create the brain, which consists of one hundred +billion neurons. It seems to be a mathematical impossibility to create the + +human brain from our genes, yet it happens every time an embryo is +conceived. How can so much information be crammed into something so +small? + +The answer, Dr. Markram believes, is that nature uses shortcuts. The +key to his approach is that certain modules of neurons are repeated over +and over again once Mother Nature finds a good template. If you look at +microscopic slices of the brain, at first you see nothing but a random +tangle of neurons. But upon closer examination, patterns of modules that +are repeated over and over appear." +"(Modules, in fact, are one reason why it is possible to assemble large +skyscrapers so rapidly. Once a single module is designed, it is possible to +repeat it endlessly on the assembly line. Then you can rapidly stack +them on top of one another to create the skyscraper. Once the +paperwork is all signed, an apartment building can be assembled using +modules in a few months.) + +The key to Dr. Markram’s Blue Brain project is the “neocortical +column,” a module that is repeated over and over in the brain. In + + humans, each column is about two millimeters tall, with a diameter of +half a millimeter, and contains sixty thousand neurons. (As a point of +comparison, rat neural modules contain only ten thousand neurons +each.) It took ten years, from 1995 to 2005, for Dr. Markram to map the +neurons in such a column and to figure out how it worked. Once that +was deciphered, he then went to IBM to create massive iterations of +these columns." +"He is the eternal optimist. In 2009, at a TED conference, he claimed he +could finish the project in ten years. (Most likely, this will be for a +stripped-down version of the human brain without any attachment to +the other lobes or to the senses.) But he has claimed, “If we build it +correctly, it should speak and have an intelligence and behave very +much as a human does.” + +Dr. Markram is a skilled defender of his work. He has an answer for +everything. When critics say that he is treading on forbidden territory, +he counters, “As scientists, we need to be not afraid of the truth. We +need to understand our brain. It’s natural that people would think that +the brain is sacred, that we shouldn’t tamper with it because it may be +where the secrets of the soul are. But I think, quite honestly, that if the +planet understood how the brain functions, we would resolve conflicts" +"everywhere. Because people would understand how trivial and how +deterministic and how controlled conflicts and reactions and +misunderstandings are.” + +When faced with the final criticism that he is “playing God,” he says, +“I think we’re far from playing God. God created the whole universe. +We’re just trying to build a little model.” + +IS IT REALLY A BRAIN? + +Although these scientists claim that their computer simulation of the +brain will begin to reach the capability of the human brain by around +2020, the main question is, How realistic is this simulation? Can the cat +simulation, for example, catch a mouse? Or play with a ball of yarn?" +"The answer is no. These computer simulations try to match the sheer +power of the neurons firing in the cat brain, but they cannot duplicate +the way in which the regions of the brain are hooked together. The IBM +simulation is only for the thalamocortical system (i.e., the channel that +connects the thalamus to the cortex). The system does not have a +physical body, and hence all the complex interactions between the brain +and the environment are missing. The brain has no parietal lobe, so it + + has no sensory or motor connections with the outside world. And even +within the thalamocortical system, the basic wiring does not respect the +thinking process of a cat. There are no feedback loops and memory +circuits for stalking prey or finding a mate. The computerized cat brain +is a blank slate, devoid of any memories or instinctual drives. In other +words, it cannot catch a mouse." +"So even if it is possible to simulate a human brain by around 2020, +you will not be able to have a simple conversation with it. Without a +parietal lobe, it would be like a blank slate without sensations, devoid of +any knowledge of itself, people, and the world around it. Without a +temporal lobe, it would not be able to talk. Without a limbic system, it +would not have any emotions. In fact, it would have less brain power +than a newborn infant. + +The challenge of hooking up the brain to the world of sensations, +emotions, language, and culture is just beginning. + +THE SLICE-AND-DICE APPROACH + +The next approach, favored by the Obama administration, is to map the +neurons of the brain directly. Instead of using transistors, this approach +analyzes the actual neural pathways of the brain. There are several +components to it." +"One way to proceed is to physically identify each and every neuron +and synapse of the brain. (The neurons are usually destroyed by this +process.) This is called the anatomical approach. Another path is to +decipher the ways in which electrical signals flow across neurons when +the brain is performing certain functions. (The latter approach, which +stresses identifying the pathways of the living brain, is the one that +seems to be favored by the Obama administration.)" +"The anatomical approach is to take apart the cells of an animal brain, +neuron by neuron, using the “slice-and-dice” method. In this way, the +full complexity of the environment, the body, and memories are already +encoded in the model. Instead of approximating a human brain by +assembling a huge number of transistors, these scientists want to identify +each neuron of the brain. After that, perhaps each neuron can be +simulated by a collection of transistors so that you’d have an exact +replica of the human brain, complete with memory, personality, and +connection to the senses. Once someone’s brain is fully reversed +engineered in this way, you should be able to have an informative +conversation with that person, complete with memories and a +personality." +"No new physics is required to finish the project. Using a device similar +to a meat sheer in a delicatessen, Dr. Gerry Rubin of the Howard Hughes +Medical Institute has been slicing the brain of a fruit fly. This is not an +easy task, since the fruit fly brain is only three hundred micrometers +across, a tiny speck compared to the human brain. The fruit fly brain +contains about 150,000 neurons. Each slice, which is only fifty-billionths +of a meter across, is meticulously photographed with an electron +microscope, and the images are fed into a computer. Then a computer +program tries to reconstruct the wiring, neuron by neuron. At the +present rate, Dr. Rubin will be able to identify every neuron in the fruit +fly brain in twenty years. + +The snail-like pace is due, in part, to current photographic technology," +"The snail-like pace is due, in part, to current photographic technology, + +since a standard scanning microscope operates at about ten million +pixels per second. (That is about a third of the resolution achieved by a +standard TV screen per second.) The goal is to have an imaging machine +that can process ten billion pixels per second, which would be a world +record. + +The problem of how to store the data pouring in from the microscope +is also staggering. Once his project gets up to speed, Rubin expects to +scan about a million gigabytes of data per day for just a single fruit fly, +so he envisions filling up huge warehouses full of hard drives. On top of +that, since every fruit fly brain is slightly different, he has to scan +hundreds of fruit fly brains in order to get an accurate approximation of +one." +"Based on working with the fruit fly brain, how long will it take to +eventually slice up the human brain? “In a hundred years, I’d like to +know how human consciousness works. The ten- or twenty-year goal is +to understand the fruit fly brain,” he says. + +This method can be speeded up with several technical advances. One +possibility is to use an automated device, so that the tedious process of +slicing the brain and analyzing each slide is done by machine. This could +rapidly reduce the time for the project. Automation, for example, vastly +reduced the cost of the Human Genome Project (although it was +budgeted at $3 billion, it was accomplished ahead of time and under +budget, which is unheard of in Washington). Another method is to use a +large variety of dyes that will tag different neurons and pathways, +making them easier to see. An alternative approach would be to create +an automated super microscope that can scan neurons one by one with +unparalleled detail." +"Given that a complete mapping of the brain and all its senses will take +up to a hundred years, these scientists feel somewhat like the medieval + + architects who designed the cathedrals of Europe, knowing that their +grandchildren would finally complete the project. + +In addition to constructing an anatomical map of the brain, neuron by +neuron, there is a parallel effort called the “Human Connectome +Project,” which uses brain scans to reconstruct the pathways connecting +various regions of the brain. + +THE HUMAN CONNECTOME PROJECT" +"THE HUMAN CONNECTOME PROJECT + +In 2010, the National Institutes of Health announced that it was +allocating $30 million, spread out over five years, to a consortium of +universities (including Washington University in St. Louis and the +University of Minnesota), and a $8.5 million grant over three years to a +consortium led by Harvard University, Massachusetts General Hospital, +and UCLA. With this level of short-term funding, of course, researchers +cannot fully sequence the entire brain, but the funding was meant to +jump-start the effort." +"Most likely, this effort will be folded into the BRAIN project, which +will vastly accelerate this work. The goal is to produce a neuronal map +of the human brain’s pathways that will elucidate brain disorders such as +autism and schizophrenia. One of the leaders of the Connectome Project, +Dr. Sebastian Seung, says, “Researchers have conjectured that the +neurons themselves are healthy, but maybe they are just wired together +in an abnormal way. But we’ve never had the technology to test that +hypothesis until now.” If these diseases are actually caused by the +miswiring of the brain, then the Human Connectome Project may give us +an invaluable clue as to how to treat these conditions." +"When considering the ultimate goal of imaging the entire human +brain, sometimes Dr. Seung despairs of ever finishing this project. He +says, “In the seventeenth century, the mathematician and philosopher +Blaise Pascal wrote of his dread of the infinite, his feeling of +insignificance at contemplating the vast reaches of outer space. And as a +scientist, I’m not supposed to talk about my feelings.... I feel curiosity, +and I feel wonder, but at times I have also felt despair.” But he and +others like him persist, even if their project will take multiple +generations to finish. They have reason to hope, since one day +automated microscopes will tirelessly take the photographs and +artificially intelligent machines will analyze them twenty-four hours a +day. But right now, just imaging the human brain with ordinary electron +microscopes would consume about one zettabyte of data, which is +equivalent to all the data compiled in the world today on the web." +"Dr. Seung even invites the public to participate in this great project by + + visiting a website called EyeWire. There, the average “citizen scientist” +can view a mass of neural pathways and is asked to color them in + +(staying within their boundaries). It’s like a virtual coloring book, except +images are of the actual neurons in the retina of an eye, taken by an +electron microscope. + +THE ALLEN BRAIN ATLAS + +Finally, there is a third way to map the brain. Instead of analyzing the +brain by using computer simulations or by identifying all the neural +pathways, yet another approach was taken with a generous grant of +$100 million from Microsoft billionaire Paul Allen. The goal was to +construct a map or atlas of the mouse brain, with the emphasis on +identifying the genes responsible for creating the brain." +"It is hoped that this understanding of how genes are expressed in the +brain will help in understanding autism, Parkinson’s, Alzheimer’s, and +other disabilities. Since a large number of mouse genes are found in +humans, it’s possible that findings here will give us insight into the +human brain. + +With this sudden infusion of funds, the project was completed in 2006, +and its results are freely available on the web. A follow-up project, the +Allen Human Brain Atlas, was announced soon afterward, with the hope +of creating an anatomically and genetically complete 3-D map of the +human brain. In 2011, the Allen Institute announced that it had mapped +the biochemistry of two human brains, finding one thousand anatomical +sites with one hundred million data points detailing how genes are +expressed in the underlying biochemistry. The study confirmed that 82 +percent of our genes are expressed in the brain." +"“Until now, a definitive map of the human brain, at this level of detail, +simply hasn’t existed,” says Dr. Allen Jones of the Allen Institute. “The +Allen Human Brain Atlas provides never-before-seen views into our most +complex and most important organ,” he adds. + +OBJECTIONS TO REVERSE ENGINEERING + +Scientists who have dedicated their lives to reverse engineering the brain +realize that decades of hard work lie ahead of them. But they are also +convinced of the practical implications of their work. They feel that even + + partial results will help decode the mystery of mental diseases that have +afflicted humans throughout our history." +"The cynics, however, may claim that, after this arduous task is +finished, we will have a mountain of data with no understanding of how +it all fits together. For example, imagine a Neanderthal who one day +comes across the complete blueprint for an IBM Blue Gene computer. All +the details are there in the blueprint, down to the very last transistor. +The blueprint is huge, taking up thousands of square feet of paper. The +Neanderthal may be dimly aware that this blueprint is the secret of a +super-powerful machine, but the sheer mass of technical data means +nothing to him. + +Similarly, the fear is that, after spending billions deciphering the +location of every neuron of the brain, we won’t be able to understand +what it all means. It may take many more decades of hard work to see +how the whole thing functions." +"For example, the Human Genome Project was a smashing success in +sequencing all the genes that make up the human genome, but it was a +huge disappointment for those who expected immediate cures for +genetic diseases. The Human Genome Project was like a gigantic +dictionary, with twenty-three thousand entries but no definitions. Page +after page of this dictionary is blank, yet the spelling of each gene is +perfect. The project was a breakthrough, but at the same time it’s just +the first step in a long journey to figure out what these genes do and +how they interact. + +Similarly, just having a complete map of every single neural +connection in the brain does not guarantee that we will know what these +neurons are doing and how they react. Reverse engineering is the easy +part; after that, the hard part begins—making sense of all this data. + +THE FUTURE" +"THE FUTURE + +But assume for now that the moment has finally arrived. With much +fanfare, scientists solemnly announce that they have successfully reverse +engineered the entire human brain. + +Then what? + +One immediate application is to find the origins of certain mental + + diseases. It’s thought that many mental diseases are not caused by the +massive destruction of neurons, but by a simple misconnection. Think of +genetic diseases that are caused by a single mutation, like Huntington’s +disease, Tay-Sachs, or cystic fibrosis. Out of three billion base pairs, a +single misspelling (or repetition) can cause uncontrollable flailing of +your limbs and convulsions, as in Huntington’s disease. Even if the +genome is 99.9999999 percent accurate, a tiny flaw might invalidate the +entire sequence. That is why gene therapy has targeted these single +mutations as possible genetic diseases that can be fixed." +"Likewise, once the brain is reverse engineered, it might be possible to +run simulations of the brain, deliberately disrupting a few connections to +see if you can induce certain illnesses. Only a handful of neurons may be +responsible for major disruptions of our cognition. Locating this tiny +collection of misfiring neurons may be one of the jobs of the reverse- +engineered brain." +"One example might be Capgras delusion, in which you see someone +you recognize as your mother, but you believe that person to be an +impostor. According to Dr. V. S. Ramachandran, this rare disease might +be due to a misconnection between two parts of the brain. The fusiform +gyrus in the temporal lobe is responsible for recognizing the face of your +mother, but the amygdala is responsible for your emotional response in +seeing your mother. When the connection between these two centers is +disrupted, an individual can recognize his mother’s face perfectly well, +but, since there is no emotional response, he is also convinced that she is +an impostor." +"Another use for the reverse-engineered brain is to pinpoint precisely +which cluster of neurons is misfiring. Deep brain stimulation, as we’ve +seen, involves using tiny probes to dampen the activity of a tiny portion +of the brain, such as Broadmann’s area 25, in the case of certain severe +forms of depression. Using the reverse-engineered map, it might be +possible to find precisely where the neurons are misfiring, which may +involve only a handful of neurons. + +A reversed-engineered brain would also be of great help to AI. Vision +and face recognition are done effortlessly by the brain, but they still +elude our most advanced computers. For example, computers can +recognize with 95 percent or greater accuracy human faces that look +straight ahead and are part of a small data bank, but if you show the" +"computer the same face from different angles or a face that’s not in the +database, the computer will most likely fail. Within .1 seconds, we can +recognize familiar faces from different angles; it’s so easy for our brains +that we are not even aware we are doing it. Reverse engineering the +brain may reveal the mystery of how this is done. + + More complicated would be diseases that involve multiple failures of +the brain, such as schizophrenia. This disorder involves several genes, +plus interactions with the environment, which in turn cause unusual +activity in several areas of the brain. But even there, a reverse- +engineered brain would be able to tell precisely how certain symptoms +(such as hallucinations) are formed, and this might pave the way for a +possible cure." +"A reverse-engineered brain would also solve such basic but unresolved +questions as how long-term memories are stored. It is known that certain +parts of the brain, such as the hippocampus and amygdala, store +memories, but how the memory is dispersed through various cortices +and then reassembled to create a memory is still unclear. + +Once the reverse-engineered brain is fully functional, then it will be +time to turn on all its circuits to see if it can respond like a human (i.e., +to see if it can pass the Turing test). Since long-term memory is already +encoded in the neurons of the reverse-engineered brain, it should be +obvious very quickly whether the brain can respond in a way +indistinguishable from a human. + +Finally, there is one impact of reverse engineering the brain that is +rarely discussed but is on many people’s minds: immortality. If +consciousness can be transferred into a computer, does that mean we +don’t have to die?" +"Speculation is never a waste of time. It clears away the +deadwood in the thickets of deduction. + +—ELIZABETH PETERS + +We are a scientific civilization.... That means a civilization in +which knowledge and its integrity are crucial. Science is only a +Latin word for knowledge.... Knowledge is our destiny. + +—JACOB BRONOWSKI + +12 THE FUTURE MIND BEYOND MATTER + +Can consciousness exist by itself, free from the constraints of the +physical body? Can we leave our mortal body and, like spirits, wander +around this playground called the universe? This was explored on Star" +"Trek, when Captain Kirk of the starship Enterprise encounters a +superhuman race, almost a million years more advanced than the +Federation of Planets. They are so advanced that they have long since +abandoned their frail, mortal bodies, and now inhabit pulsating globes of +pure energy. It has been millennia since they could feel intoxicating +sensations, such as breathing fresh air, touching another’s hand, or +feeling physical love. Their leader, Sargon, welcomes the Enterprise to +their planet. Captain Kirk accepts the invitation, acutely aware that this +civilization could instantly vaporize the Enterprise if it wanted to. + +But unknown to the crew, these super beings have a fatal weakness. +For all their advanced technology, they have been severed for hundreds +of thousands of years from their physical bodies. As such, they yearn to +feel the rush of physical sensations and long to become human again." +"One of these super beings, in fact, is evil and determined to gain +possession of the physical bodies of the crew. He wants to live like a +human, even if it means destroying the mind of the body’s owner. Soon a +battle breaks out on the deck of the Enterprise, as the evil entity seizes +control of Spock’s body and the crew fights back. + +Scientists have asked themselves, Is there a law of physics preventing +the mind from existing without the body? In particular, if the conscious +human mind is a device that constantly creates models of the world and +simulates them into the future, is it possible to create a machine that can +simulate this entire process? + +Previously, we mentioned the possibility of having our bodies placed +in pods, as in the movie Surrogates, while we mentally control a robot. +The problem here is that our natural body will still gradually wither +away, even if our robot surrogate keeps on going. Serious scientists are" +"contemplating whether we can actually transfer our minds into a robot +so we can become truly immortal. And who wouldn’t want a chance at +eternal life? As Woody Allen once said, “I don’t want to live forever +through my works. I want to live forever by not dying.” + +Actually, millions of people already claim that it is possible for the +mind to leave the body. In fact, many insist that they have done it +themselves. + +OUT-OF-BODY EXPERIENCES + +The idea of minds without bodies is perhaps the oldest of our +superstitions, embedded deep within our myths, folklore, dreams, and + + perhaps even our genes. Every society, it seems, has some tale of ghosts +and demons who can enter and leave the body at will." +"Sadly, many innocents were persecuted to exorcize the demons that +were supposedly possessing their bodies. They probably suffered from +mental illness, such as schizophrenia, in which victims are often haunted +by voices generated by their own minds. Historians believe that one of +the Salem witches who was hung in 1692 for being possessed probably +had a rare genetic condition, called Huntington’s disease, that causes +uncontrolled flailing of the limbs. + +Today some people claim that they have entered a trancelike state in +which their consciousness has left their body and is free to roam +throughout space, even able to look back at their mortal body. In a poll +of thirteen thousand Europeans, 5.8 percent claimed they had had an +out-of-body experience. Interviews with people in the United States +show similar numbers." +"Nobel laureate Richard Feynman, always curious about new +phenomena, once placed himself in a sensory deprivation tank and tried +to leave his physical body. He was successful. He would later write that +he felt that he had left his body, drifted into space, and saw his +motionless body when he looked back. However, Feynman later +concluded that this was probably just his imagination, caused by sensory +deprivation. + +Neurologists who have studied this phenomenon have a more prosaic +explanation. Dr. Olaf Blanke and his colleagues in Switzerland may have" +"located the precise place in the brain that generates out-of-body +experiences. One of his patients was a forty-three-year-old woman who +suffered from debilitating seizures that came from her right temporal +lobe. A grid of about one hundred electrodes was placed over her brain +in order to locate the region responsible for her seizures. When the +electrodes stimulated the area between the parietal and temporal lobes, +she immediately had the sensation of leaving her body. “I see myself +lying in bed, from above, but I only see my legs and lower trunk!” she +exclaimed. She felt she was floating six feet above her body." +"When the electrodes were turned off, however, the out-of-body +sensation disappeared immediately. In fact, Dr. Blanke found that he +could turn the out-of-body sensation on and off, like a light switch, by +repeatedly stimulating this area of the brain. As we saw in Chapter 9, +temporal lobe epileptic lesions can induce the feeling that there are evil +spirits behind every misfortune, so the concept of spirits leaving the +body is perhaps part of our neural makeup. (This may also explain the +presence of supernatural beings. When Dr. Blanke analyzed a twenty- + + two-year-old woman who was suffering from intractable seizures, he +found that, by stimulating the temporoparietal area of the brain, he +could induce the sensation that there was a shadowy presence behind +her. She could describe this person, who even grabbed her arms, in +detail. His position would change with each appearance, but he would +always appear behind her.)" +"Human consciousness, I believe, is the process of continually forming +a model of the world, in order to simulate the future and carry out a +goal. In particular, the brain is receiving sensations from the eyes and +inner ear to create a model of where we are in space. However, when +the signals from our eyes and ears are in contradiction, we become +confused about our location. We often get nauseous and throw up. For +example, many people develop sea sickness when they are on a rocking +boat because their eyes, looking at the cabin walls, tell them that they +are stationary, but their inner ear tells them that they are swaying. The +mismatch between these signals causes them to become nauseous. The +remedy is to look out at the horizon so that the visual image matches the +signals from the inner ear. (This same sense of nausea can be induced +even if you are stationary. If you look at a spinning garbage can with +bright vertical stripes painted on it, the stripes seem to move" +"horizontally across your eyes, giving you the sensation that you are +moving. But your inner ear says you are stationary. The resulting +mismatch causes you to throw up after a few minutes, even if you are +sitting in a chair.) + +The messages from the eyes and inner ear can also be disrupted +electrically, at the boundary of the temporal and parietal lobes, and this +is the origin of out-of-body experiences. When this sensitive area is +touched, the brain gets confused about where it is located in space. +(Notably, temporary loss of blood or oxygen or excess carbon dioxide in +the blood can also cause a disruption in the temporoparietal region and +induce out-of-body experiences, which may explain the prevalence of +these sensations during accidents, emergencies, heart attacks, etc.) + +NEAR-DEATH EXPERIENCES" +"NEAR-DEATH EXPERIENCES + +But perhaps the most dramatic category of out-of-body experiences are +the near-death stories of individuals who have been declared dead but +then mysteriously regained consciousness. In fact, 6 to 12 percent of +survivors of cardiac arrest report having near-death experiences. It’s as +though they have cheated death itself. When interviewed, they have +dramatic tales of the same experience: they left their body and drifted +toward a bright light at the end of a long tunnel." +"The media have seized upon this, with numerous best sellers and TV +documentaries devoted to these theatrical stories. Many bizarre theories +have been proposed to explain near-death experiences. In a poll of two +thousand people, fully 42 percent believed that near-death experiences +were proof of contact with the spiritual world that lies beyond death. +(Some believe that the body releases endorphins—natural narcotics— +before death. This may explain the euphoria that people feel, but not the +tunnel and the bright lights.) Carl Sagan even speculated that near-death +experiences were a reliving of the trauma of birth. The fact that these +individuals recount very similar experiences doesn’t necessarily +corroborate their glimpses into the afterlife; in fact, it seems to indicate +that there is some deep neurological event happening. + +Neurologists have looked into this phenomenon seriously and suspect +that the key may be the decrease of blood flow to the brain that often" +"accompanies near-death cases, and which also occurs in fainting. Dr. +Thomas Lempert, a neurologist at the Castle Park Clinic in Berlin, +conducted a series of experiments on forty-two healthy individuals, +causing them to faint under controlled laboratory conditions. Sixty +percent of them had visual hallucinations (e.g., bright lights and colored +patches). Forty-seven percent of them felt that they were entering +another world. Twenty percent claimed to have encountered a +supernatural being. Seventeen percent saw a bright light. Eight percent +saw a tunnel. So fainting can mimic all the sensations people have in +near-death experiences. But precisely how does this happen?" +"The mystery of how fainting can simulate near-death experiences may +be solved by analyzing the experiences of military pilots. The U.S. Air +Force, for example, contacted neurophysiologist Dr. Edward Lambert to +analyze military pilots who blacked out when experiencing high g forces +(i.e., when executing a tight turn in a jet or pulling out of a dive). Dr. +Lampert placed pilots in an ultracentrifuge at the Mayo Clinic in +Rochester, Minnesota, which spun them around in a circle until they +experienced high g forces. As blood drained from their brain, they would +become unconscious after fifteen seconds of experiencing several g’s of +acceleration." +"He found that after only five seconds, the blood flow to the pilots’ eyes +diminished, so that their peripheral vision dimmed, creating the image +of a long tunnel. This could explain the tunnel that is often seen by +people having a near-death experience. If the periphery of your vision +blacks out, all you see is the narrow tunnel in front of you. But because +Dr. Lampert could carefully adjust the velocity of the centrifuge by +turning a dial, he found he could keep the pilots in this state indefinitely, +allowing him to prove that this tunnel vision is caused by loss of blood +flow to the periphery of the eye. + + CAN CONSCIOUSNESS LEAVE YOUR BODY? + +Some scientists who have investigated near-death and out-of-body +experiences are convinced that they are by-products of the brain itself +when it is placed under stressful conditions and its wiring gets confused. +However, there are other scientists who believe that one day, when our" +"technology is sufficiently advanced decades from now, one’s +consciousness may truly be able to leave the body. Several controversial +methods have been suggested." +"One method has been pioneered by futurist and inventor Dr. Ray +Kurzweil, who believes that consciousness may one day be uploaded into +a supercomputer. We once spoke at a conference together, and he told +me his fascination with computers and artificial intelligence began when +he was five years old and his parents bought him all sorts of mechanical +devices and toys. He loved to tinker with these devices, and even as a +child he knew he was destined to become an inventor. At MIT, he +received his doctorate under Dr. Marvin Minsky, one of the founders of +AI. Afterward, he cut his teeth applying pattern-recognition technology +to musical instruments and text-to-sound machines. He was able to +translate AI research in these areas into a string of companies. (He sold +his first company when he was only twenty.) His optical reader, which +could recognize text and convert it into sound, was heralded as an aid +for the blind, and was even mentioned by Walter Cronkite on the +evening news." +"In order to be a successful inventor, he said to me, you always have to +be ahead of the curve, to anticipate change, not react to it. Indeed, Dr. +Kurzweil loves to make predictions, and many of them have mirrored +the remarkable exponential growth of digital technology. He made the +following predictions: + +• By 2019, a $1,000 PC will have the computing power of the human +brain—twenty million billion calculations per second. (This number +is obtained by taking the one hundred billion neurons of the brain, +multiplying one thousand connections per neuron, and two hundred +calculations per second per connection.) + +• By 2029, a $1,000 PC will be a thousand times more powerful than +the human brain; the human brain itself will be successfully +reversed engineered. + +• By 2055, $1,000 of computing power will equal the processing + + power of all the humans on the planet. (He adds modestly, “I may +be off by a year or two.”)" +"power of all the humans on the planet. (He adds modestly, “I may +be off by a year or two.”) + +In particular, the year 2045 looms as an important one for Dr. +Kurzweil, since that is when he believes the “singularity” will take hold. +By then, he claims, machines will have surpassed humans in intelligence +and in fact will have created next-generation robots even smarter than +themselves. Since this process can continue indefinitely, it means, +according to Dr. Kurzweil, a never-ending acceleration of the power of +machines. In this scenario, we should either merge with our creations or +step out of their way. (Although these dates are in the far future, he told +me that he wants to live long enough to see the day when humans +finally become immortal; that is, he wants to live long enough to live +forever.)" +"As we know from Moore’s law, at a certain point computer power can +no longer advance by creating smaller and smaller transistors. In +Kurzweil’s opinion, the only way to expand computing power further +would be to increase overall size, which would leave robots scavenging +for more computer power by devouring the minerals of the Earth. Once +the planet has become a gigantic computer, robots may be forced to go +into outer space, searching for more sources of computer power. +Eventually, they may consume the power of entire stars. + +I once asked him if this cosmic growth of computers could alter the +cosmos itself. Yes, he replied. He told me that he sometimes looks at the +night sky, wondering if on some distant planet intelligent beings have +already attained the singularity. If so, then perhaps they should leave +some mark on the stars themselves that might be visible to the naked +eye." +"One limitation he told me, is the speed of light. Unless these machines +can break the light barrier, this exponential rise in power may hit a +ceiling. When that happens, says Kurzweil, perhaps they will alter the +laws of physics themselves. + +Anyone who makes predictions with such precision and scope +naturally invites criticism like a lightning rod, but it doesn’t seem to faze +him. People can quibble about this or that prediction, since Kurzweil has +missed some of his deadlines, but he is mainly concerned about the +thrust of his ideas, which predict the exponential growth of technology. +To be fair, most people working in the field of AI whom I have +interviewed agree that some form of a singularity will happen, but they +disagree sharply on when it might occur and how it will unfold. For" +"example, Bill Gates, cofounder of Microsoft, believes that no one alive +today will live to see the day when computers are smart enough to pass +for a human. Kevin Kelly, an editor for Wired magazine, has said, +“People who predict a very utopian future always predict that it is going +to happen before they die.” + +Indeed, one of Kurzweil’s many goals is to bring his father back to life. +Or rather, he wants to create a realistic simulation. There are several +possibilities, but all are still highly speculative. + +Kurzweil proposes that perhaps DNA can be extracted from his father +(from his grave site, relatives, or organic materials he left behind). +Contained within roughly twenty-three thousand genes would be a +complete blueprint to re-create the body of that individual. Then a clone +could be grown from the DNA." +"This is certainly a possibility. I once asked Dr. Robert Lanza of the +company Advanced Cell Technology how he was able to bring a long- +dead creature “back to life,” making history in the process. He told me +that the San Diego Zoo asked him to create a clone of a banteng, an +oxlike creature that had died out about twenty-five years earlier. The +hard part was extracting a usable cell for the purpose of cloning. +However, he was successful, and then he FedExed the cell to a farm, +where it was implanted into a female cow, which then gave birth to this +animal. Although no primate has ever been cloned, let alone a human, +Lanza feels it’s a technical problem, and that it’s only a matter of time +before someone clones a human." +"This would be the easy part, though. The clone would be genetically +equivalent to the original, but without its memories. Artificial memories +might be uploaded to the brain using the pioneering methods described +in Chapter 5, such as inserting probes into the hippocampus or creating +an artificial hippocampus, but Kurzweil’s father has long passed, so it’s +impossible to make the recording in the first place. The best one can do +is to assemble piecemeal all historical data about that person, such as by +interviewing others who possess relevant memories, or accessing their +credit card transactions, etc., and then inputting them into the program. + +A more practical way of inserting a person’s personality and memory +would be to create a large data file containing all known information +about a person’s habits and life. For example, today it is possible to store +all your e-mail, credit card transactions, records, schedules, electronic" +"diaries, and life history onto a single file, which can create a remarkably +accurate picture of who you are. This file would represent your entire +“digital signature,” representing everything that is known about you. It +would be remarkably accurate and intimate, detailing what wines you +like, how you spend vacations, what kind of soap you use, your favorite + + singer, and so on." +"Also, with a questionnaire, it would be possible to create a rough +approximation of Kurzweil’s father’s personality. His friends, relatives, +and associates would fill out a questionnaire containing scores of +questions about his personality, such as whether he was shy, curious, +honest, hardworking, etc. Then they would assign a number to each trait +(e.g., a “10” would mean that you are very honest). This would create a +string of hundreds of numbers, each one ranking a specific personality +trait. Once this vast set of numbers was compiled, a computer program +would take these data and approximate how he would behave in +hypothetical situations. Let’s say that you are giving a speech and are +confronted with an especially obnoxious heckler. The computer program +would then scan the numbers and then predict one of several possible +outcomes (e.g., ignore the heckler, heckle back, or get into a brawl with +the heckler). In other words, his basic personality would be reduced to a" +"the heckler). In other words, his basic personality would be reduced to a +long string of numbers, each from 1 to 10, which can be used by a +computer to predict how he would react to new situations." +"The result would be a vast computer program that would respond to +new situations roughly the way the original person would have, using +the same verbal expressions and having the same quirks, all tempered +with the memories of that person. + +Another possibility would be to forgo the whole cloning process and +simply create a robot resembling the original person. It would then be +straightforward to insert this program into a mechanical device that +looks like you, talks with the same accent and mannerisms, and moves +its arms and limbs the same way that you do. Adding your favorite +expressions (e.g., “you know ...”) would also be easy. + +Of course, today it would be easy to detect that this robot is a fake. +However, in the coming decades, it may be possible to get closer and +closer to the original, so it might be good enough to fool some people. + +But this raises a philosophical question. Is this “person” really the +same as the original? The original is still dead, so the clone or robot is," +"strictly speaking, still an impostor. A tape recorder, for example, might +reproduce a conversation we have with perfect fidelity, but that tape +recorder is certainly not the original. Can a clone or robot that behaves +just like the original be a valid substitute? + +IMMORTALITY + + These methods have been criticized because this process does not +realistically input your true personality and memories. A more faithful +way of putting a mind into a machine is via the Connectome Project, +which we discussed in the last chapter and which seeks to duplicate, +neuron for neuron, all the cellular pathways of your brain. All your +memories and personality quirks are already embedded in the +connectome." +"The Connectome Project’s Dr. Sebastian Seung notes that some people +pay $100,000 or more to have their brains frozen in liquid nitrogen. +Certain animals, like fish and frogs, can be frozen solid in a block of ice +in winter yet be perfectly healthy after thawing out in spring. This is +because they use glucose as an antifreeze to alter the freezing point of +water in their blood. Thus their blood remains liquid, even though they +are encased in solid ice. This high concentration of glucose in the human +body, however, would probably be fatal, so freezing the human brain in +liquid nitrogen is a dubious pursuit because expanding ice crystals would +rupture the cell wall from the inside (and also, as brain cells die, calcium +ions rush in, causing the brain cells to expand until they finally rupture). +In either case, brain cells would most likely not survive the freezing +process." +"Rather than freezing the body and having the cells rupture, a more +reliable process to attain immortality might be to have your connectome +completed. In this scenario, your doctor would have all your neural +connections on a hard drive. Basically, your soul would now be on a +disk, reduced to information. Then at a future point, someone would be +able to resurrect your connectome and, in principle, use either a clone or +a tangle of transistors to bring you back to life. + +The Connectome Project, as we mentioned, is still far from being able +to record a human’s neural connections. But as Dr. Seung says, “Should + +we ridicule the modern seekers of immortality, calling them fools? Or +will they someday chuckle over our graves?” + +MENTAL ILLNESS AND IMMORTALITY" +"MENTAL ILLNESS AND IMMORTALITY + +Immortality may have its drawbacks, however. The electronic brains +being built so far contain only the connections between the cortex and +the thalamus. The reverse-engineered brain, lacking a body, might begin +to suffer from sensory isolation and even manifest signs of mental illness, +as prisoners do when they are placed into solitary confinement. Perhaps +the price of creating an immortal, reverse-engineered brain is madness." +"Subjects who are placed in isolation chambers, where they are +deprived of any contact with the outside world, eventually hallucinate. +In 2008, BBC-TV aired a science program titled Total Isolation, in which +they followed six volunteers as they were placed inside a nuclear bunker, +alone and in complete darkness. After just two days, three of the +volunteers began to see and hear things—snakes, cars, zebras, and +oysters. After they were released, doctors found that all of them suffered +from mental deterioration. One subject’s memory suffered a 36 percent +drop. One can imagine that, after a few weeks or months of this, most of +them might go insane." +"To maintain the sanity of a reverse-engineered brain, it might be +essential to connect it to sensors that receive signals from the +environment so it would be able to see and feel sensations from the +outside world. But then another problem arises: it might feel that it is a +grotesque freak, an unwieldy scientific guinea pig living at the mercy of +a science experiment. Because this brain has the same memory and +personality as the original human, it would crave human contact. And +yet, lurking inside the memory of some supercomputer, with a macabre +jungle of electrodes dangling outside, the reverse-engineered brain +would be repulsive to any human. Bonding with it would be impossible. +Its friends would turn away. + +THE CAVEMAN PRINCIPLE + +At this point, what I call the Caveman Principle starts to kick in. Why do + +so many reasonable predictions fail? And why would someone not want +to live forever inside a computer?" +"The Caveman Principle is this: given a choice between high-tech or +high-touch, we opt for high-touch every time. For example, if we are +given a choice between tickets to see our favorite musician live or a CD +of the same musician in concert, which would we choose? Or if we are +given a choice between tickets to visit the Taj Mahal or just seeing a +beautiful picture of it, which would we prefer? More than likely the live +concert and the airplane tickets. + +This is because we have inherited the consciousness of our apelike +ancestors. Some of our basic personality has probably not changed much +in the last one hundred thousand years, since the first modern humans +emerged in Africa. A large portion of our consciousness is devoted to +looking good and trying to impress members of the opposite sex and our +peers. This is hardwired into our brains. + + More likely, given our basic, apelike consciousness, we will merge +with computers only if this enhances but does not totally replace our +present-day body." +"The Caveman Principle probably explains why some reasonable +predictions about the future never materialized, such as “the paperless +office.” Computers were supposed to banish paper from the office; +ironically, computers have actually created even more paper. This is +because we are descended from hunters who need “proof of the kill” +(i.e., we trust concrete evidence, not ephemeral electrons dancing on a +computer screen that vanish when you turn it off). Likewise, the +“peopleless city,” where people would use virtual reality to go to +meetings instead of commuting, never materialized. Commuting to cities +is worse than ever. Why? Because we are social animals who like to +bond with others. Videoconferencing, although useful, cannot pick up +the full spectrum of subtle information offered via body language. A +boss, for example, may want to ferret out problems in his staff and +therefore wants to see them squirm and sweat under interrogation. You +can do this only in person. + +CAVEMEN AND NEUROSCIENCE" +"CAVEMEN AND NEUROSCIENCE + +When I was a child, I read Isaac Asimov’s Foundation Trilogy and was +deeply influenced by it. First, it forced me to ask a simple question: +What will technology look like fifty thousand years in the future, when +we have a galactic empire? I also couldn’t help wondering throughout +the novel, Why do humans look and act the same as they do now? I +thought that surely thousands of years into the future humans should +have cyborg bodies with superhuman abilities. They should have given +up their puny human forms millennia ago." +"I came up with two answers. First, Asimov wanted to appeal to a +young audience willing to buy his book, so he had to create characters +that those people could identify with, including all their faults. Second, +perhaps people in the future will have the option to have superpowered +bodies but prefer to look normal most of the time. This would be +because their minds have not changed since humans first emerged from +the forest, and so acceptance from their peers and the opposite sex still +determines what they look like and what they want out of life. + +So now let us apply the Caveman Principle to the neuroscience of the +future. At the minimum, it means that any modification of the basic +human form would have to be nearly invisible on the outside. We don’t +want to resemble a refugee from a science-fiction movie, with electrodes +dangling from our head. Brain implants that might insert memories or +increase our intelligence will be adopted only if nanotechnology can" +"make microscopic sensors and probes that are invisible to the naked eye. +In the future, it might be possible to make nanofibers, perhaps made of +carbon nanotubes one molecule thick, so thin that they would be able to +make contact with neurons with surgical precision and yet leave our +appearance unaltered, with our mental capabilities enhanced. + +Meanwhile, if we need to be connected to a supercomputer to upload +information, we won’t want to be tied to a cable jacked into our spinal +cord, as in The Matrix. The connection will have to be wireless so we can +access vast amounts of computer power simply by mentally locating the +nearest server. + +Today we have cochlear implants and artificial retinas that can give +the gift of sound and sight to patients, but in the future our senses will +be enhanced using nanotechnology while we preserve our basic human +form. For instance, we might have the option of enhancing our muscles, +via genetic modification or exoskeletons. There could be a human body" +"shop from which we could order new spare parts as the old ones wear +out, but these and other physical enhancements of the body would have +to avoid abandoning the human form. + +Another way to use this technology in accordance with the Caveman +Principle is to use it as an option, rather than a permanent way of life. +One might want the option of plugging into this technology and then +unplugging soon afterward. Scientists may want to boost their +intelligence to solve a particularly tricky problem. But afterward, they +will be able to take off their helmets or implants and go about their +business. In this way, we are not caught looking like a space cadet to our +friends. The point is that no one would force you to do any of this. We +would want the option of enjoying the benefits of this technology +without the downside of looking silly." +"So in the centuries to come, it is likely our bodies will look very +similar to the ones we possess today, except that they will be perfect and +have enhanced powers. It is a relic of our apelike past that our +consciousness is dominated by ancient desires and wishes. + +But what about immortality? As we have seen, a reverse-engineered +brain, with all the personality quirks of the original person, would +eventually go mad if placed inside a computer. Furthermore, connecting +this brain to external sensors so it could feel sensations from its +environment would create a grotesque monstrosity. One partial solution +to this problem is to connect the reverse-engineered brain to an +exoskeleton. If the exoskeleton acts like a surrogate, then the reverse- +engineered brain would be able to enjoy sensations such as touch and +sight without looking grotesque. Eventually the exoskeleton would go" +"wireless, so that it would act like a human but be controlled by a +reverse-engineered brain “living” inside a computer. + +This surrogate would have the best of both worlds. Being an +exoskeleton, it would be perfect. It would possess superpowers. Since it +would be wirelessly connected to a reverse-engineered brain inside a +large computer, it would also be immortal. And lastly, since it would +sense the environment and look appealingly like a real human, it would +not have as many problems interacting with humans, many of whom +will also have probably opted for this procedure. So the actual +connectome would reside in a stationary supercomputer, although its +consciousness would manifest itself in a perfect, mobile surrogate body. + +All this would require a level of technology far beyond anything that +is attainable today. However, given the rapid pace of scientific progress, +this could become a reality by the end of the century. + +GRADUAL TRANSFERENCE" +"GRADUAL TRANSFERENCE + +Right now the process of reverse engineering involves transferring the +information within the brain, neuron for neuron. The brain has to be cut +up into thin slices, since MRI scans are not yet refined enough to identify +the precise neural architecture of the living brain. So until that can be +done, the obvious disadvantage of this approach is that you have to die +before you can be reversed engineered. Since the brain degenerates +rapidly after death, its preservation would have to take place +immediately, which is very difficult to accomplish." +"But there may be one way to attain immortality without having to die +first. This idea was pioneered by Dr. Hans Moravec, former director of +the Artificial Intelligence Laboratory at Carnegie Mellon University. +When I interviewed him, he told me that he envisions a time in the +distant future when we will be able to reverse engineer the brain for a +specific purpose: to transfer the mind into an immortal robotic body +even while a person is still conscious. If we can reverse engineer every +neuron of the brain, why not create a copy made of transistors, +duplicating precisely the thought processes of the mind? In this way, you +do not have to die in order to live forever. You can be conscious +throughout the entire process." +"He told me that this process would have to be done in steps. First, you +lie on a stretcher, next to a robot lacking a brain. Next, a robotic surgeon +extracts a few neurons from your brain, and then duplicates these +neurons with some transistors located in the robot. Wires connect your +brain to the transistors in the robot’s empty head. The neurons are then + + thrown away and replaced by the transistor circuit. Since your brain +remains connected to these transistors via wires, it functions normally +and you are fully conscious during this process. Then the super surgeon +removes more and more neurons from your brain, each time duplicating +these neurons with transistors in the robot. Midway through the +operation, half of your brain is empty; the other half is connected by + +wires to a large collection of transistors inside the robot’s head. +Eventually all the neurons in your brain have been removed, leaving a +robot brain that is an exact duplicate of your original brain, neuron for +neuron." +"At the end of this process, however, you rise from the stretcher and +find that your body is perfectly formed. You are handsome and beautiful +beyond your dreams, with superhuman powers and abilities. As a perk, +you are also immortal. You gaze back at your original mortal body, +which is just an aging shell without a mind. + +This technology, of course, is far ahead of our time. We cannot reverse +engineer the human brain, let alone make a carbon copy made of +transistors. (One of the main criticisms of this approach is that a +transistorized brain may not fit inside the skull. In fact, given the size of +electronic components, the transistorized brain may be the size of a huge +supercomputer. In this sense, this proposal begins to resemble the +previous one, in which the reverse-engineered brain is stored in a huge +supercomputer, which in turn controls a surrogate. But the great +advantage of this approach is that you don’t have to die; you’d be fully +conscious during the process.)" +"One’s head spins contemplating these possibilities. All of them seem to +be consistent with the laws of physics, but the technological barriers to +achieving them are truly formidable. All these proposals for uploading +consciousness into a computer require a technology that is far into the +future. + +But there is one last proposal for attaining immortality that does not +require reverse engineering the brain at all. It requires simply a +microscopic “nanobot” that can manipulate individual atoms. So why +not live forever in your own natural body, but with a periodic “tune-up” +that makes it immortal? + +WHAT IS AGING? + +This new approach incorporates the latest research into the aging +process. Traditionally there has been no consensus among biologists + + about the source of the aging process. But within the last decade, a new +theory has gained gradual acceptance and has unified many strands of" +"research into aging. Basically, aging is the buildup of errors, at the +genetic and cellular level. As cells get older, errors begin to build up in +their DNA and cellular debris also starts to accumulate, which makes +cells sluggish. As cells begin to slowly malfunction, skin begins to sag, +bones become frail, hair falls out, and our immune system deteriorates. +Eventually, we die. + +But cells also have error-correcting mechanisms. Over time, however, +even these error-correcting mechanisms begin to fail, and aging +accelerates. The goal, therefore, is to strengthen the natural cell-repair +mechanisms, which can be done via gene therapy and the creation of +new enzymes. But there is also another way: using “nanobot” +assemblers." +"One of the linchpins of this futuristic technology is something called +the “nanobot,” or an atomic machine, which patrols the bloodstream, +zapping cancer cells, repairing the damage from the aging process, and +keeping us forever young and healthy. Nature has already created some +nanobots, in the form of immune cells that patrol the body in the blood. +But these immune cells attack viruses and foreign bodies, not the aging +process. + +Immortality is within reach if these nanobots can reverse the ravages +of the aging process at the molecular and cellular level. In this vision, +nanobots are like immune cells, tiny police patrolling your bloodstream. +They attack any cancer cells, neutralize viruses, and clean out the debris +and mutations. Then the possibility of immortality would be within +reach using our own bodies, not some robot or clone. + +NANOBOTS—REAL OR FANTASY?" +"NANOBOTS—REAL OR FANTASY? + +My own personal philosophy is that if something is consistent with the +laws of physics, then it becomes an engineering and economics problem +to build it. The engineering and economic hurdles may be formidable, of +course, making it impractical for the present, but nonetheless it is still +possible. + +On the surface, the nanobot is simple: an atomic machine with arms +and clippers that grabs molecules, cuts them at specific points, and then +splices them back together. By cutting and pasting various atoms, the" +"nanobot can create almost any known molecule, like a magician pulling +something out of a hat. It can also self-reproduce, so it is necessary to +build only one nanobot. This nanobot will then take raw materials, +digest them, and create millions of other nanobots. This could trigger a +second Industrial Revolution, as the cost of building materials plummets. +One day, perhaps every home will have its own personal molecular +assembler, so you can have anything you want just by asking for it." +"But the key question is: Are nanobots consistent with the laws of +physics? Back in 2001, two visionaries practically came to blows over +this crucial question. At stake was nothing less than a vision of the entire +future of technology. On one side was the late Richard Smalley, a Nobel +laureate in chemistry and skeptical of nanobots. On the other side was +Eric Drexler, one of the founding fathers of nanotechnology. Their +titanic, tit-for-tat battle played out in the pages of several scientific +magazines from 2001 to 2003." +"Smalley said that, at the atomic scale, new quantum forces emerge +that make nanobots impossible. The error made by Drexler and others, +he claimed, is that the nanobot, with its clippers and arms, cannot +function at the atomic scale. There are novel forces (e.g., the Casimir +force) that cause atoms to repel or attract one another. He called this the +“sticky, fat fingers” problem, because the fingers of the nanobot are not +like delicate, precise pliers and wrenches. Quantum forces get in the +way, so it’s like trying to weld metals together while wearing gloves that +are many inches thick. Furthermore, every time you try to weld two +pieces of metal together, these pieces are either repelled or stick to you, +so you can never grab one properly." +"Drexler then fired back, stating that nanobots are not science fiction— +they actually exist. Think of the ribosomes in our own body. They are +essential in creating and molding DNA molecules. They can cut and +splice DNA molecules at specific points, which makes possible the +creation of new DNA strands. + +But Smalley wasn’t satisfied, stating that ribosomes are not all-purpose +machines that can cut and paste anything you want; they work +specifically on DNA molecules. Moreover, ribosomes are organic +chemicals that need enzymes to speed up the reaction, which occurs +only in a watery environment. Transistors are made of silicon, not water, +so these enzymes would never work, he concluded. Drexel, in turn, + +mentioned that catalysts can work even without water. This heated +exchange went back and forth through several rounds. In the end, like +two evenly matched prizefighters, both sides seemed exhausted. Drexler +had to admit that the analogy to workers with cutters and blowtorches" +"was too simplistic, that quantum forces do get in the way sometimes. But +Smalley had to concede that he was unable to score a knockout blow. +Nature had at least one way of evading the “sticky, fat fingers” problem, +with ribosomes, and perhaps there might be other subtle, unforeseen +ways as well. + +Regardless of the details of this debate, Ray Kurzweil is convinced that +these nanobots, whether or not they have fat, sticky fingers, will one day +shape not just molecules, but society itself. He summarized his vision +when he said, “I’m not planning to die.... I see it, ultimately, as an +awakening of the whole universe. I think the whole universe right now is +basically made up of dumb matter and energy and I think it will wake +up. But if it becomes transformed into this sublimely intelligent matter +and energy, I hope to be part of that.”" +"As fantastic as these speculations are, they are only a preface to the +next leap in speculation. Perhaps one day the mind will not only be free +of its material body, it will also be able to explore the universe as a +being of pure energy. The idea that consciousness will one day be free to +roam among the stars is the ultimate dream. As incredible as it may +sound, this is well within the laws of physics. + +13 THE MIND AS PURE ENERGY + +The idea that one day consciousness may spread throughout the +universe has been considered seriously by physicists. Sir Martin Rees, the +Royal Astronomer of Great Britain, has written, “Wormholes, extra +dimensions, and quantum computers open up speculative scenarios that +could transform our entire universe eventually into a ‘living cosmos’!”" +"But will the mind one day be freed of its material body to explore the +entire universe? This was the theme explored in Isaac Asimov’s classic +science-fiction tale “The Last Question.” (He would fondly recall that this +was his favorite science-fiction short story of all the ones he had +written.) In it, billions of years into the future, humans will have placed +their physical bodies in pods on an obscure planet, freeing their minds to +control pure energy throughout the galaxy. Instead of surrogates made +of steel and silicon, these surrogates are pure energy beings that can +effortlessly roam the distant reaches of space, past exploding stars, +colliding galaxies, and other wonders of the universe. But no matter how +powerful humanity has become, it is helpless as it witnesses the ultimate +death of the universe itself in the Big Freeze. In desperation, humanity +constructs a supercomputer to answer the final question: Can the death" +"constructs a supercomputer to answer the final question: Can the death +of the universe be reversed? The computer is so large and complex that +it has to be placed in hyperspace. But the computer simply responds that +there is insufficient information to give an answer." +"Eons later, as the stars begin to turn dark, all life in the universe is +about to die. But then the supercomputer finally discovers a way to +reverse the death of the universe. It collects dead stars from across the +universe, combines them into one gigantic cosmic ball, and ignites it. As +the ball explodes, the supercomputer announces, “Let there be light!” + +And there was light. + +So humanity, once freed of the physical body, is capable of playing +God and creating a new universe. + +At first, Asimov���s fantastic tale of beings made of pure energy roaming + +across the universe sounds impossible. We are accustomed to thinking of +beings made of flesh and blood, which are at the mercy of the laws of +physics and biology, living and breathing on Earth, and bound by the +gravity of our planet. The concept of conscious entities of energy, +soaring across the galaxy, unimpeded by the limitations of material +bodies, is a strange one." +"Yet this dream of exploring the universe as beings of pure energy is +well within the laws of physics. Think of the most familiar form of pure +energy, a laser beam, which is capable of containing vast amounts of +information. Today trillions of signals in the form of phone calls, data +packages, videos, and e-mail messages are transmitted routinely by fiber¬ +optic cables carrying laser beams. One day, perhaps sometime in the +next century, we will be able to transmit the consciousness of our brains +throughout the solar system by placing our entire connectomes onto +powerful laser beams. A century beyond that, we may be able to send +our connectome to the stars, riding on a light beam." +"(This is possible because the wavelength of a laser beam is +microscopic, i.e., measured in millionths of a meter. That means you can +compress vast amounts of information on its wave pattern. Think of +Morse code. The dots and dashes of Morse code can easily be +superimposed on the wave pattern of a laser beam. Even more +information can be transferred onto a beam of X-rays, which has a +wavelength even smaller than an atom.) + +One way to explore the galaxy, unbound by the messy restrictions of +ordinary matter, is to place our connectomes onto laser beams directed +at the moon, the planets, and even the stars. Given the crash program to +find the pathways of the brain, the complete connectome of the human +brain will be available late in this century, and a form of the connectome +capable of being placed on a laser beam might be available in the next +century." +"The laser beam would contain all the information necessary to +reassemble a conscious being. Although it may take years or even +centuries for the laser beam to reach its destination, from the point of +view of the person riding on the laser beam, the trip would be +instantaneous. Our consciousness is essentially frozen on the laser beam +as it soars through empty space, so the trip to the other side of the +galaxy appears to take place in the blink of an eye." +"In this way, we avoid all the unpleasant features of interplanetary and +interstellar travel. First, there is no need to build colossal booster +rockets. Instead, you simply press the “on” button of a laser. Second, +there are no powerful g forces crushing your body as you accelerate into +space. Instead, you are boosted instantly to the speed of light, since you +are immaterial. Third, you don’t have to suffer the hazards of outer +space, such as meteor impacts and deadly cosmic rays, since asteroids +and radiation pass right through you harmlessly. Fourth, you don’t have +to freeze your body or endure years of boredom as you lumber tediously +inside a conventional rocket. Instead, you zip across space at the fastest +velocity in the universe, frozen in time." +"Once we reach our destination, there would have to be a receiving +station to transfer the data of the laser beam onto a mainframe +computer, which then brings the conscious being back to life. The code +that was imprinted onto the laser beam now takes control of the +computer and redirects its programming. The connectome directs the +mainframe computer to begin simulating the future to attain its goals +(i.e., it becomes conscious). + +This conscious being inside the mainframe then sends signals +wirelessly to a robotic surrogate body, which has been waiting for us at +the destination. In this way, we suddenly “wake up” on a distant planet +or star, as if the trip took place in the blink of an eye, inside the robotic +body of our surrogate. All the complex computations take place in a +large mainframe computer, which directs the movements of a surrogate +to carry on with our business on a distant star. We are oblivious to the +hazards of space travel, as if nothing had happened." +"Now imagine a vast network of these stations spread out over the solar +system and even the galaxy. From our point of view, hopping from star +to star would be almost effortless, traveling at the speed of light in +journeys that are instantaneous. At each station, there is a robotic +surrogate waiting for us to enter its body, just like an empty hotel room +waiting for us to check in. We arrive at our destination refreshed and +equipped with a superhuman body. + +The type of surrogate robotic body that awaits us at the end of this + + journey would depend on the mission. If the job is to explore a new +world, then the surrogate body would have to work in harsh conditions. +It would have to adjust to a different gravitational field, a poisonous + +atmosphere, freezing-cold or blistering-hot temperatures, different day- +night cycles, and a constant rain of deadly radiation. To survive under +these harsh conditions, the surrogate body would have to have super +strength and super senses." +"If the surrogate body is purely for relaxation, then it would be +designed for leisurely activities. It would maximize the pleasure of +soaring through space on skis, surfboards, kites, gliders, or planes, or of +sending a ball through space propelled by the swing of a bat, club, or +racket. + +Or if the job is to mingle with and study the local natives, then the +surrogate would approximate the bodily characteristics of the indigenous +population (as in the movie Avatar )." +"Admittedly, in order to create this network of laser stations in the first +place, it might be necessary first to travel to the planets and stars in the +old-fashioned way, in more conventional rocket ships. Then one could +build the first set of these laser stations. (Perhaps the fastest, cheapest, +and most efficient way of creating this interstellar network would be to +send self-replicating robotic probes throughout the galaxy. Because they +can make copies of themselves, starting with one such probe, after many +generations there would be billions of such probes streaming out in all +directions, each one creating a laser station wherever it lands. We will +discuss this further in the next chapter.) + +But once the network is fully established, one can conceive of a +continual stream of conscious beings roaming the galaxy, so that at any +time crowds of people are leaving and arriving from distant parts of the +galaxy. Any laser station in the network might look like Grand Central +Station." +"As futuristic as this may sound, the basic physics for this concept are +already well established. This includes placing vast amounts of data onto +laser beams, sending this information across thousands of miles, and +then decoding the information at the other end. The major problems +facing this idea are therefore not in the physics, but in the engineering. +Because of this, it may take us until the next century to send our entire +connectome on laser beams powerful enough to reach the planets. It +might take us still another century to beam our minds to the stars. + +To see if this is feasible, it is instructive to do a few simple, back-of- +the-envelope calculations. The first problem is that the photons inside a" +"pencil-thin laser beam, although they appear to be in perfectly parallel +formation, actually diverge slightly in space. (When I was a child, I used +to shine a flashlight at the moon and wonder if the light ever reached it. +The answer is yes. The atmosphere absorbs over 90 percent of the +original beam, leaving some remaining to reach the moon. But the real +problem is that the image the flashlight finally casts on the moon is +miles across. This is because of the uncertainty principle; even laser +beams must diverge slowly. Since you cannot know the precise location +of the laser beam, it must, by the laws of quantum physics, slowly spread +out over time.)" +"But beaming our connectomes to the moon does not give us much +advantage, since it’s easier simply to remain on Earth and control the +lunar surrogate directly by radio. The delay is only about a second when +issuing commands to the surrogate. The real advantage comes when +controlling surrogates on the planets, since a radio message may take +hours to reach a surrogate there. The process of issuing a series of radio +commands to a surrogate, waiting for a response, and issuing another +command would be painfully slow, taking days on end. + +If you want to send a laser beam to the planets, you first have to +establish a battery of lasers on the moon, well above the atmosphere, so +there is no air to absorb the signal. Shot from the moon, a laser beam to +the planets could arrive in a matter of minutes to a few hours. Once the +laser beam has sent the connectome to the planets, then it’s possible to +directly control the surrogate without any delay factors at all." +"So establishing a network of these laser stations throughout the solar +system could be accomplished by the next century. But the problems are +magnified when we try sending the beam to the stars. This means that +we must have relay stations placed on asteroids and space stations along +the way, in order to amplify the signal, reduce errors, and send the +message to the next relay station. This could potentially be done by +using the comets that lie between our sun and the nearby stars. For +example, extending about a light-year from the sun (or one-quarter of +the distance to the nearest star) is the Oort cloud of comets. It is a +spherical shell of billions of comets, many of which lie motionless in +empty space. There is probably a similar Oort cloud of comets +surrounding the Centauri star system, which is our nearest stellar +neighbor. Assuming that this Oort cloud also extends a light-year from" +"those stars, then fully half the distance from our solar system to the next +contains stationary comets on which we can build laser relay stations. + + Another problem is the sheer amount of data that must be sent by +laser beam. The total information contained in one’s connectome, +according to Dr. Sebastian Seung, is roughly one zettabyte (that is, a 1 +with twenty-one zeros after it). This is roughly equivalent to the total +information contained in the World Wide Web today. Now consider +shooting a battery of laser beams into space carrying this vast mountain +of information. Optical fibers can carry terabytes of data per second (a 1 +with twelve zeros after it). Within the next century, advances in +information storage, data compression, and bundling of laser beams may +increase this efficiency by a factor of a million. This means that it would +take a few hours or so to send the beam into space carrying all the +information contained within the brain." +"So the problem is not the sheer amount of data sent on laser beams. In +principle, laser beams can carry an unlimited amount of data. The real +bottlenecks are the receiving stations at either end, which must have +switches that rapidly manipulate this amount of data at blinding speed. +Silicon transistors may not be fast enough to handle this volume of data. +Instead, we might have to use quantum computers, which compute not +on silicon transistors but on individual atoms. At present, quantum +computers are at a primitive level, but by the next century they might be +powerful enough to handle zettabytes of information. + +FLOATING BEINGS OF ENERGY" +"FLOATING BEINGS OF ENERGY + +Another advantage of using quantum computers to process this +mountain of data is the chance to create beings of energy that can hover +and float in the air, which appear frequently in science fiction and +fantasy. These beings would represent consciousness in its purest form. +At first, however, they may seem to violate the laws of physics, since +light always travels at the speed of light. + +But in the last decade, headlines were made by physicists at Harvard +University who announced that they were able to stop a beam of light +dead in its tracks. These physicists apparently accomplished the +impossible, slowing down a light beam to a leisurely pace until it could" +"be placed in a bottle. Capturing a light beam in a bottle is not so +fantastic if you look carefully at a glass of water. As a light beam enters +the water, it slows down, bending as it enters the water at an angle. +Similarly, light bends as it enters glass, making telescopes and +microscopes possible. The reason for all this comes from the quantum +theory. + +Think of the old Pony Express, which delivered the mail in the" +"Think of the old Pony Express, which delivered the mail in the + + nineteenth century in the American West. Each pony could sprint +between relay stations at great speed. But the bottleneck was the delay +factor at each relay station, where the mail, rider, and pony had to be +exchanged. This slowed down the average velocity of the mail +considerably. In the same way, in the vacuum between atoms, light still +travels at c, the speed of light, which is roughly 186,282 miles per second. +However, when it hits atoms, light is delayed; it is briefly absorbed and +then reemitted by atoms, sending it on its way a fraction of a second +later. This slight delay is responsible for light beams, on average, +apparently slowing down in glass or water." +"The Harvard scientists exploited this phenomenon, taking a container +of gas and carefully cooling it down to near absolute zero. At these +freezing temperatures, the gas atoms absorbed a light beam for longer +and longer time periods before reemitting it. Thus, by increasing this +delay factor, they could slow down the light beam until it came to rest. +The light beam still traveled at the speed of light between the gas atoms, +but it spent an increasing amount of time being absorbed by them. + +This raises the possibility that a conscious being, instead of assuming +control of a surrogate, may prefer to remain in the form of pure energy +and roam, almost ghostlike, as pure energy." +"So in the future, as laser beams are sent to the stars containing our +connectomes, the beam may be transferred into a cloud of gas molecules +and then contained in a bottle. This “bottle of light” is very similar to a +quantum computer. Both of them have a collection of atoms vibrating in +unison, in which the atoms are in phase with one another. And both of +them can do complex computations that are far beyond an ordinary +computer’s capability. So if the problems of quantum computers can be +solved, it may also give us the ability to manipulate these “bottles of +light.” + +FASTER THAN LIGHT? + +We see, then, that all these problems are ones of engineering. There is no +law of physics preventing traveling on an energy beam in the next +century or beyond. So this is perhaps the most convenient way of +visiting the planets and stars. Instead of riding on a light beam, as the +poets dreamed, we become the light beam." +"To truly realize the vision expressed in Asimov’s science-fiction tale, +we need to ask if faster-than-light intergalactic travel is truly possible. In +his short story, beings of immense power move freely between galaxies +separated by millions of light-years. + + Is this possible? To answer this question, we have to push the very +boundaries of modern quantum physics. Ultimately, things called +“wormholes” may provide a shortcut through the vastness of space and +time. And beings made of pure energy rather than matter would have a +decisive advantage in passing through them." +"Einstein, in some sense, is like the cop on the block, stating that you +cannot go faster than light, the ultimate velocity in the universe. +Traveling across the Milky Way galaxy, for example, would take one +hundred thousand years, even sailing on a laser beam. Although only an +instant of time has passed for the traveler, the time on the home planet +has progressed one hundred thousand years. And passing between +galaxies involves millions to billions of light-years. + +But Einstein himself left a loophole in his work. In his general theory +of relativity of 1915, he showed that gravity arose from the warping of +space-time. Gravity is not the “pull” of a mysterious invisible force, as +Newton once thought, but actually a “push” caused by space itself +bending around an object. Not only did this brilliantly explain the +bending of starlight passing near stars and the expansion of the universe, +it left open the possibility of the fabric of space-time stretching until it +ripped." +"In 1935, Einstein and his student Nathan Rosen introduced the +possibility that two black-hole solutions could be joined back to back, +like Siamese twins, so if you fell into one black hole, you could, in +principle, pass out of the other one. (Imagine joining two funnels at their +ends. Water that drains through one funnel emerges from the other.) +This “wormhole,” also called the Einstein-Rosen Bridge, introduced the + +possibility of portals or gateways between universes. Einstein himself +dismissed the possibility that you could pass through a black hole, since +you would be crushed in the process, but several subsequent +developments have raised the possibility of faster-than-light travel +through a wormhole." +"First, in 1963, mathematician Roy Kerr discovered that a spinning +black hole does not collapse into a single dot, as previously thought, but +into a rotating ring, spinning so fast that centrifugal forces prevent it +from collapsing. If you fell through the ring, then you could pass into +another universe. The gravitational forces would be large, but not +infinite. This would be like Alice’s Looking Glass, where you could pass +your hand through the mirror and enter a parallel universe. The rim of +the Looking Glass would be the ring forming the black hole itself. Since +Kerr’s discovery, scores of other solutions of Einstein’s equations have +shown that you can, in principle, pass between universes without being +immediately crushed. Since every black hole seen so far in space is + + spinning rapidly (some of them clocked at one million miles per hour), +this means that these cosmic gateways could be commonplace." +"In 1988, physicist Dr. Kip Thorne of Cal Tech and his colleagues +showed that, with enough “negative energy,” it might be possible to +stabilize a black hole so that a wormhole becomes “transversable” (i.e., +you can freely pass through it both ways without being crushed). +Negative energy is perhaps the most exotic substance in the universe, +but it actually exists and can be created (in microscopic quantities) in +the laboratory. + +So here is the new paradigm. First, an advanced civilization would +concentrate enough positive energy at a single point, comparable to a +black hole, to open up a hole through space connecting two distant +points. Second, it would amass enough negative energy to keep the +gateway open, so that it is stable and does not close the instant you enter +it." +"We can now put this idea into proper perspective. Mapping the entire +human connectome should be possible late in this century. An +interplanetary laser network could be established early in the next +century, so that consciousness can be beamed across the solar system. No +new law of physics would be required. A laser network that can go +between the stars may have to wait until the century after that. But a + +civilization that can play with wormholes will have to be thousands of +years ahead of us in technology, stretching the boundaries of known +physics." +"All this, then, has direct implications for whether consciousness can +pass between universes. If matter comes close to a black hole, the gravity +becomes so intense that your body becomes “spaghettified.” The gravity +pulling on your leg is greater than the gravity pulling on your head, so +your body is stretched by tidal forces. In fact, as you approach the black +hole, even the atoms of your body are stretched until the electrons are +ripped from the nuclei, causing your atoms to disintegrate." +"(To see the power of tidal forces, just look at the tides of Earth and the +rings of Saturn. The gravity of the moon and sun exert a pull on Earth, +causing the oceans to rise several feet during high tide. And if a moon +comes too close to a giant planet like Saturn, the tidal forces will stretch +the moon and eventually tear it apart. The distance at which moons get +ripped apart by tidal forces is called the Roche limit. The rings of Saturn +lie exactly at the Roche limit, so they might have been caused by a moon +that wandered too close to the mother planet.) + +Even if we enter a spinning black hole and use negative energy to + + stabilize it, then, the gravity fields still might be so powerful that we’d +be spaghettified." +"stabilize it, then, the gravity fields still might be so powerful that we’d +be spaghettified. + +But here is where laser beams have an important advantage over +matter when passing through a wormhole. Laser light is immaterial, so it +cannot be stretched by tidal forces as it passes near a black hole. Instead, +light becomes “blue-shifted” (i.e., it gains energy and its frequency +increases). Even though the laser beam is distorted, the information +stored on it is untouched. For example, a message in Morse code carried +by a laser beam becomes compressed, but the information content +remains unchanged. Digital information is untouched by tidal forces. So +gravitational forces, which can be fatal to beings made of matter, may be +harmless to beings traveling on light beams. + +In this way, consciousness carried by a laser beam, because it is +immaterial, has a decisive advantage over matter in passing through a +wormhole." +"Laser beams have another advantage over matter when passing +through a wormhole. Some physicists have calculated that a microscopic +wormhole, perhaps the size of an atom, might be easier to create. Matter + +would not be able to pass through such a tiny wormhole. But X-ray +lasers, with a wavelength smaller than an atom, might possibly be able +to pass through without difficulty." +"Although Asimov’s brilliant short story was clearly a work of fantasy, +ironically a vast interstellar network of laser stations might already exist +within the galaxy, yet we are so primitive that we are totally unaware of +it. To a civilization thousands of years ahead of us, the technology to +digitalize their connectomes and send them to the stars would be child’s +play. In that case, it is conceivable that intelligent beings are already +zapping their consciousness across a vast network of laser beams in the +galaxy. Nothing we observe with our most advanced telescopes and +satellites prepares us to detect such an intergalactic network. + +Carl Sagan once lamented the possibility that we might live in a world +surrounded by alien civilizations and not have the technology to realize +it. + +Then the next question is: What lurks in the alien mind?" +"Then the next question is: What lurks in the alien mind? + +If we were to encounter such an advanced civilization, what kind of +consciousness might it have? One day, the destiny of the human race +may rest on answering this question. + + Sometimes I think that the surest sign that intelligent life exists +elsewhere in the universe is that none of it has tried to contact +us. + +—BILL WATTERSON + +Either intelligent life exists in outer space or it doesn’t. Either +thought is frightening. + +—ARTHUR C. CLARKE + +14 THE ALIEN MIND" +"—ARTHUR C. CLARKE + +14 THE ALIEN MIND + +In War of the Worlds by H. G. Wells, aliens from Mars attack Earth +because their home planet is dying. Armed with death rays and giant +walking machines, they quickly incinerate many cities and are on the +verge of seizing control of Earth’s major capitals. Just as the Martians +are crushing all signs of resistance and our civilization is about to be +reduced to rubble, they are mysteriously stopped cold in their tracks. +With all their advanced science and weaponry, they failed to factor in an +onslaught from the lowliest of creatures: our germs." +"That single novel created an entire genre, launching a thousand +movies like Earth vs. the Flying Saucers and Independence Day. Most +scientists cringe, however, when they see how the aliens are described. +In the movies, aliens are often depicted as creatures with some sense of +human values and emotions. Even with glowing green skin and huge +heads, they still look like us to a certain degree. They also tend to speak +perfect English. + +But, as many scientists have pointed out, we may have much more in +common with a lobster or a sea slug than we do with an alien from +space." +"As with silicon consciousness, alien consciousness will most likely +have the general features described in our space-time theory; that is, the +ability to make a model of the world and then calculate how it will +evolve in time to achieve a goal. But while robots can be programmed so +that they emotionally bond with humans and have goals compatible +with ours, alien consciousness may have neither. It’s likely to have its +own set of values and goals, independent of humanity. One can only +speculate what these might be. + +Physicist Dr. Freeman Dyson of the Institute for Advanced Study at + + Princeton was a consultant to the movie 2001 . When he finally saw the +movie, he was delighted, not because of its dazzling special effects, but +because it was the first Hollywood movie ever to present an alien" +"consciousness, with desires, goals, and intentions totally foreign to ours. +For the first time, the aliens were not simply human actors flailing +about, trying to act menacing in cheesy monster costumes. Instead, alien +consciousness was presented as something totally orthogonal to human +experience, something entirely outside our ken. + +In 2011, Stephen Hawking raised another question. The noted +cosmologist made headlines when he said that we must be prepared for +a possible alien attack. He said that if we ever encounter an alien +civilization, it will be more advanced than ours and hence will pose a +mortal threat to our very existence." +"We have only to see what happened to the Aztecs when they +encountered the bloodthirsty Hernan Cortes and his conquistadors to +imagine what might happen with such a fateful encounter. Armed with +technology that the Bronze Age Aztecs had never seen before, such as +iron swords, gunpowder, and the horse, this small band of cutthroats +was able to crush the ancient Aztec civilization in a matter of months in +1521. + +All this raises these questions: What will alien consciousness be like? +How will their thinking process and goals differ from ours? What do +they want? + +FIRST CONTACT IN THIS CENTURY + +This is not an academic question. Given the remarkable advances in +astrophysics, we may actually make contact with an alien intelligence in +the coming decades. How we respond to them could determine one of +the most pivotal events in human history. + +Several advances are making this day possible." +"Several advances are making this day possible. + +First, in 2011 the Kepler satellite, for the first time in history, gave +scientists a “census” of the Milky Way galaxy. After analyzing light from +thousands of stars, the Kepler satellite found that one in two hundred +might harbor an earthlike planet in the habitable zone. For the first time, +we can therefore calculate how many stars within the Milky Way galaxy +might be earthlike: about a billion. As we look at the distant stars, we +have genuine reason to wonder if anyone is looking back at us. + + So far, more than one thousand exoplanets have been analyzed in" +"So far, more than one thousand exoplanets have been analyzed in + +detail by earthbound telescopes. (Astronomers find them at the rate of +about two exoplanets per week.) Unfortunately, nearly all of them are +Jupiter-size planets, probably devoid of any earthlike creatures, but +there are a handful of “super earths,” rocky planets that are a few times +larger than Earth. Already, the Kepler satellite has identified about 2,500 +candidate exoplanets in space, a handful of which look very much like +Earth. These planets are at just the right distance from their mother stars +so that liquid oceans can exist. And liquid water is the “universal +solvent” that dissolves most organic chemicals like DNA and proteins." +"In 2013, NASA scientists announced their most spectacular discovery +using the Kepler satellite: two exoplanets that are near twins of Earth. +They are located 1,200 light-years away in the constellation Lyra. They +are only 60 percent and 40 percent larger than Earth. More important, +both lie within the habitable zone of their mother star, so there is a +possibility that they have liquid oceans. Of all the planets analyzed so +far, they are the closest to being mirror images of Earth. + +Furthermore, the Hubble Space Telescope has given us an estimate of +the total number of galaxies in the visible universe: one hundred billion. +Therefore, we can calculate the number of earthlike planets in the visible +universe: one billion times one hundred billion, or one hundred +quintillion earthlike planets." +"This is a truly astronomical number, so the odds of life existing in the +universe are astronomically large, especially when you consider that the +universe is 13.8 billion years old, and there has been plenty of time for +intelligent empires to rise—and perhaps fall. In fact, it would be more +miraculous if another advanced civilization did not exist. + +SETI AND ALIEN CIVILIZATIONS + +Second, radio telescope technology is becoming more sophisticated. So +far, only about one thousand stars have been closely analyzed for signs +of intelligent life, but in the coming decade this number could rise by a +factor of one million. + +Using radio telescopes to hunt for alien civilizations dates back to +1960, when astronomer Frank Drake initiated Project Ozma (after the +Queen of Oz), using the twenty-five-meter radio telescope in Green" +"Bank, West Virginia. This marked the birth of the SETI project (the +Search for Extraterrestrial Intelligence). Unfortunately, no signals from +aliens were picked up, but in 1971 NASA proposed Project Cyclops, +which was supposed to have 1,500 radio telescopes at a cost of $10 +billion. + +Not surprisingly, it never went anywhere. Congress was not amused. + +Funding did become available for a much more modest proposal: to +send a carefully coded message in 1971 to aliens in outer space. A coded +message containing 1,679 bits of information was transmitted via the +giant Arecibo radio telescope in Puerto Rico toward the Globular Cluster +Ml 3, about 25,100 light-years away. It was the world’s first cosmic +greeting card, containing relevant information about the human race. +But no reply message was received. Perhaps the aliens were not +impressed with us, or possibly the speed of light got in the way. Given +the large distances involved, the earliest date for a reply message would +be 52,174 years from now." +"Since then, some scientists have expressed misgivings about +advertising our existence to aliens in space, at least until we know their +intentions toward us. They disagree with the proponents of the METI +Project (Messaging to Extra-Terrestrial Intelligence) who actively +promote sending signals to alien civilizations in space. The reasoning +behind the METI Project is that Earth already sends vast amounts of +radio and TV signals into outer space, so a few more messages from the +METI Project will not make much difference. But the critics of METI +believe that we should not needlessly increase our chances of being +discovered by potentially hostile aliens." +"In 1995, astronomers turned to private sources to start the SETI +Institute in Mountain View, California, to centralize research and initiate +Project Phoenix, which is trying to study one thousand nearby sunlike +stars in the l,200-to-3,000-megahertz radio range. The equipment is so +sensitive that it can pick up the emissions from an airport radar system +two hundred light-years away. Since its founding, the SETI Institute has +scanned more than one thousand stars at a cost of $5 million per year, +but still no luck. + +A more novel approach is the SETI@home project, initiated by +astronomers at the University of California at Berkeley in 1999, which +uses an informal army of millions of amateur PC owners. Anyone can + +join in this historic hunt. While you are sleeping at night, your screen +saver crunches some of the data pouring in from the Arecibo radio +telescope in Puerto Rico. So far, it has signed up 5.2 million users in 234 +countries; perhaps these amateurs dream that they will be the first in" +"human history to make contact with alien life. Like Columbus’s, their +names may go down in history. The SETI @home project has grown so +rapidly that it is, in fact, the largest computer project of this type ever +undertaken. + +When I interviewed Dr. Dan Wertheimer, director of SETI@home, I +asked him how they can distinguish false messages from real ones. He +said something that surprised me. He told me that they sometimes +deliberately “seed” the data from radio telescopes with fake signals from +an imaginary intelligent civilization. If no one picks up these fake +messages, then they know that there is something wrong with their +software. The lesson here is that if your PC screen saver announces that +it has deciphered a message from an alien civilization, please do not +immediately call the police or the president of the United States. It might +be a fake message. + +ALIEN HUNTERS" +"ALIEN HUNTERS + +One colleague of mine who has dedicated his life to finding intelligent +life in outer space is Dr. Seth Shostak, director of the SETI Institute. With +his Ph.D. in physics from the California Institute of Technology, I might +have expected him to become a distinguished physics professor lecturing +to eager Ph.D. students, but instead he spends his time in an entirely +different fashion: asking for donations to the SETI Institute from wealthy +individuals, poring over possible signals from outer space, and doing a +radio show. I once asked him about the “giggle factor”—do fellow +scientists giggle when he tells them that he listens to aliens from outer +space? Not anymore, he claims. With all the new discoveries in +astronomy, the tide has turned." +"In fact, he even sticks his neck out and says flatly that we will make +contact with an alien civilization in the very near future. He has gone on +record as proclaiming that the 350-antenna Allen Telescope Array now +being built “will trip across a signal by the year 2025.” + +Isn’t that a bit risky, I asked him? What makes him so sure? One factor +working in his favor has been the explosion in the number of radio +telescopes in the last few years. Although the U.S. government does not +fund his project, the SETI Institute recently hit pay dirt when it +convinced Paul Allen (the Microsoft billionaire) to donate over $30 +million in funds to start the Allen Telescope Array at Hat Creek, +California, 290 miles north of San Francisco. It currently scans the +heavens with 42 radio telescopes, and eventually will reach up to 350. +(One problem, however, is the chronic lack of funding for these scientific +experiments. To make up for budget cuts, the Hat Creek facility is kept" +"alive through partial funding from the military.) + +One thing, he confessed to me, makes him squirm a bit, and that is +when people confuse the SETI Project with UFO hunters. The former, he +claims, is based on solid physics and astronomy, using the latest in +technology. The latter, however, base their theories on anecdotal +hearsay evidence that may or may not be based on truth. The problem is +that the mass of UFO sightings he gets in the mail are not reproducible +or testable. He urges anyone who claims to have been abducted by aliens +in a flying saucer to steal something—an alien pen or paperweight, for +example—to prove your case. Never leave a UFO empty-handed, he told +me." +"He also concludes that there is no firm evidence that aliens have +visited our planet. I then asked him whether he thought the U.S. +government was deliberately covering up evidence of an alien +encounter, as many conspiracy theorists believe. He replied, “Would +they really be so efficient at covering up a big thing like this? +Remember, this is the same government that runs the post office.” + +DRAKE’S EQUATION + +When I asked Dr. Wertheimer why he is so sure that there is alien life in +outer space, he replied that the numbers are in his favor. Back in 1961, +astronomer Frank Drake tried to estimate the number of such intelligent +civilizations by making plausible assumptions. If we start with the +number one hundred billion, the number of stars in the Milky Way +galaxy, then we can estimate the fraction of them that are similar to our" +"sun. We can reduce that number further by estimating the fraction of +them that have planets, the fraction of them that have earthlike planets, +etc. After making a number of reasonable assumptions, we come up with +an estimate of ten thousand advanced civilizations in our own Milky +Way galaxy. (Carl Sagan, with a different set of estimates, came up with +the number one million.)" +"Since then, scientists have been able to make much better estimates of +the number of advanced civilizations in our galaxy. For example, we +know there are more planets orbiting stars than Drake originally +expected, and more earthlike planets as well. But we still face a problem. +Even if we know how many earthlike twins there are in space, we still +don’t know how many of them support intelligent life. Even on Earth, it +took 4.5 billion years before intelligent beings (us) finally arose from the +swamp. For about 3.5 billion years, life-forms have existed on Earth, but +only in the last one hundred thousand years or so have intelligent beings + + like us emerged. So even on an earthlike planet like Earth itself, the rise +of truly intelligent life has been very difficult. + +WHY DON’T THEY VISIT US?" +"WHY DON’T THEY VISIT US? + +But then I asked Dr. Seth Shostak of SETI this killer question: If there are +so many stars in the galaxy, and so many alien civilizations, then why +don’t they visit us? This is the Fermi paradox, named for Enrico Fermi, +the Nobel laureate who helped build the atomic bomb and unlocked the +secrets of the nucleus of the atom. + +Many theories have been proposed. For one, the distance between +stars might be too great. It would take about seventy thousand years for +our most powerful chemical rockets to reach the stars nearest to Earth. +Perhaps a civilization thousands to millions of years more advanced than +ours may solve this problem, but there’s another possibility. Maybe they +annihilated themselves in a nuclear war. As John F. Kennedy once said, +“I am sorry to say there is too much point to the wisecrack that life is +extinct on other planets because their scientists were more advanced +than ours.”" +"But perhaps the most logical reason is this: Imagine walking down a +country road and encountering an ant hill. Do we go down to the ants + +and say, “I bring you trinkets. I bring you beads. I give you nuclear +energy. I will create an ant paradise for you. Take me to your leader”? + +Probably not. + +Now imagine that workers are building an eight-lane superhighway +next to the anthill. Would the ants know what frequency the workers are +talking on? Would they even know what an eight-lane superhighway +was? In the same fashion, any intelligent civilization that can reach +Earth from the stars would be thousands of years to millions of years +ahead of us, and we may have nothing to offer them. In other words, we +are arrogant to believe that aliens will travel trillions upon trillions of +miles just to see us. + +More than likely, we are not on their radar screen. Ironically, the +galaxy could be teaming with intelligent life-forms and we are so +primitive that we are oblivious of them. + +FIRST CONTACT" +"FIRST CONTACT + + But assume for the moment that the time will come, perhaps sooner +rather than later, when we make contact with an alien civilization. This +moment could be a turning point in the history of humanity. So the next +questions are: What do they want, and what will their consciousness be +like? + +In the movies and in science-fiction novels, the aliens often want to +eat us, conquer us, mate with us, enslave us, or strip our planet of +valuable resources. But all this is highly improbable. + +Our first contact with an alien civilization will probably not begin +with a flying saucer landing on the White House lawn. More likely, it +will happen when some teenager, running a screen saver from the +SETI@home project, announces that his or her PC has decoded signals +from the Arecibo radio telescope in Puerto Rico. Or perhaps when the +SETI project at Hat Creek detects a message that indicates intelligence." +"Our first encounter will therefore be a one-way event. We will be able +to eavesdrop on intelligent messages, but a return message may take +decades or centuries to reach them. + +The conversations that we hear on the radio may give us valuable +insight into this alien civilization. But most of the message will likely be + +gossip, entertainment, music, etc., with little scientific content. + +Then I asked Dr. Shostak the next key question: Will you keep it a +secret once First Contact is made? After all, won’t it cause mass panic, +religious hysteria, chaos, and spontaneous evacuations? I was a bit +surprised when he said no. They would give all the data to the +governments of the world and to the people. + +The next questions are: What will they be like? How do they think? + +To understand alien consciousness, perhaps it is instructive to analyze +another consciousness that is quite alien to us, the consciousness of +animals. We live with them, yet we are totally ignorant of what goes on +in their minds." +"Understanding animal consciousness, in turn, may help us understand +alien consciousness. + +ANIMAL CONSCIOUSNESS + + Do animals think? And if so, what do they think about? This question +has perplexed the greatest minds in history for thousands of years. The +Greek writers and historians Plutarch and Pliny both wrote about a +famous question that remains unsolved even today. Over the centuries, +many solutions have been given by the giants of philosophy. + +A dog is traveling down a road, looking for its master, when it +encounters a fork that branches in three directions. The dog first takes +the left path, sniffs around, and then returns, knowing that his master +has not taken that road. Then it takes the right path, sniffs, and realizes +that his master has not taken this road either. But this time, the dog +triumphantly takes the middle road, without sniffing." +"What was going on in the dog’s mind? Some of the greatest +philosophers have tackled this question, to no avail. The French +philosopher and essayist Michel de Montaigne wrote that the dog +obviously concluded that the only possible solution was to take the +middle road, a conclusion showing that dogs are capable of abstract +thought. + +But St. Thomas Aquinas, arguing in the thirteenth century, said the +opposite—that the appearance of abstract thought is not the same thing +as genuine thinking. We can be fooled by superficial appearances of + +intelligence, he claimed. + +Centuries later, there was also a famous exchange between John Locke +and George Berkeley about animal consciousness. “Beasts abstract not,” +proclaimed Locke flatly. To which Bishop Berkeley responded, “If the +fact that brutes abstract not be made the distinguishing property of that +sort of animal, I fear a great many of those that pass for man must be +reckoned into their number.”" +"Philosophers down the ages have tried to analyze this question in the +same manner: by imposing human consciousness on the dog. This is the +mistake of anthropomorphism, or assuming that animals think and +behave like us. But perhaps the real solution might be to look at this +question from the dog’s point of view, which could be quite alien. + +In Chapter 2, I gave a definition of consciousness in which animals +were part of a continuum of consciousness. Animals can differ from us in +the parameters they use to create a model of the world. Dr. David +Eagleman says that psychologists call this “umwelt,” or the reality +perceived by other animals. He notes, “In the blind and deaf world of the +tick, the important signals are temperature and the odor of butyric acid. +For the black ghost knifefish, it’s electrical fields. For the echo locating +bat, air-compressed waves. Each organism inhabits its own umwelt, + + which it presumably assumes to be the entire objective reality ‘out +there.’ ”" +"which it presumably assumes to be the entire objective reality ‘out +there.’ ” + +Consider the brain of a dog, which is constantly living in a swirl of +odors, by which it hunts for food or locates a mate. From these smells, +the dog then constructs a mental map of what exists in its surroundings. +This map of smells is totally different from the one we get from our eyes +and conveys an entirely different set of information. (Recall from +Chapter 1 that Dr. Penfield constructed a map of the cerebral cortex, +showing the distorted self-image of the body. Now imagine a Penfield +diagram of a dog’s brain. Most of it would be devoted to its nose, not its +fingers. Animals would have a totally different Penfield diagram. Aliens +in space would likely have an even stranger Penfield diagram.)" +"Unfortunately, we tend to assign human consciousness to animals, +even though animals may have a totally different world outlook. For +example, when a dog faithfully follows its master’s orders, we +subconsciously assume that the dog is man’s best friend because he likes +us and respects us. But since the dog is descended from Cards lupus (the + +gray wolf), which hunts in packs with a rigid pecking order, more than +likely the dog sees you as some sort of alpha male, or the leader of the +pack. You are, in some sense, the Top Dog. (This is probably one reason +why puppies are much easier to train than older dogs; it is likely easier +to imprint one’s presence on a puppy’s brain, while more mature dogs +realize that humans are not part of their pack.)" +"Also, when a cat enters a new room and urinates all over the carpet, +we assume that the cat is angry or nervous, and we try to find out the +reason why the cat is upset. But perhaps the cat is simply marking its +territory with the smell of its urine to ward off other cats. So the cat is +not upset at all; it’s simply warning other cats to stay out of the house, +because the house belongs to it. + +And if the cat purrs and rubs itself against your legs, we assume that it +is grateful to you for taking care of it, that this is a sign of warmth and +affection. More than likely, the cat is rubbing its hormone onto you to +claim ownership of its possession (i.e., you), to ward off other cats. In +the cat’s viewpoint, you are a servant of some sort, trained to give it +food several times a day, and rubbing its scent on you warns other cats +to stay away from this servant." +"As the sixteenth-century philosopher Michel de Montaigne once wrote, +“When I play with my cat, how do I know that she is not playing with +me rather than I with her?” + +And if the cat then stalks off to be alone, it is not necessarily a sign of +anger or aloofness. The cat is descended from the wildcat, which is a + + solitary hunter, unlike the dog. There is no alpha male to slobber over, +as in the case of the dog. The proliferation of various “animal whisperer” +programs on TV is probably a sign of the problems we encounter when +we force human consciousness and intentions onto animals." +"A bat would also have a much different consciousness, which would +be dominated by sounds. Almost blind, the bat requires constant +feedback from tiny squeaks it makes, which allow it to locate insects, +obstacles, and other bats via sonar. The Penfield map of its brain would +be quite alien to us, with a huge portion devoted to its ears. Similarly, +dolphins have a different consciousness than humans, which is also +based on sonar. Because dolphins have a smaller frontal cortex, it was +once thought that they were not so intelligent, but the dolphin +compensates for this by having a larger brain mass. If you unfold the + +neocortex of the dolphin brain, it would cover six magazine pages, while +if you unfold the neocortex of a human, it would measure only four +magazine pages. Dolphins also have very well-developed parietal and +temporal cortices to analyze sonar signals in the water and are one of +the few animals that can recognize themselves in a mirror, probably +because of this fact." +"In addition, the dolphin brain is actually structured differently from +humans’ because dolphin and human lineages diverged about ninety-five +million years ago. Dolphins have no need for a nose, so their olfactory +bulb disappears soon after birth. But thirty million years ago, their +auditory cortex exploded in size because dolphins learned to use +echolocation, or sonar, to find food. Like bats’, their world must be one +of whirling echoes and vibrations. Compared to humans, dolphins have +an extra lobe in their limbic system, called the “paralimbic” region, +which probably helps them forge strong social relations." +"Meanwhile, dolphins also have a language that is intelligent. I once +swam in a pool of dolphins for a TV special for the Science Channel. I +put sonar sensors in the pool that could pick up the clicks and whistles +used by dolphins to talk to one another. These signals were recorded and +then analyzed by computer. There is a simple way to discern if there is +an intelligence lurking among this random set of squeals and chirps. In +the English language, for example, the letter e is the most commonly +used letter of the alphabet. In fact, we can create a list of all the letters +of the alphabet and how frequently they occur. No matter what book in +English we analyze by computer, it will roughly obey the same list of +commonly found letters of the alphabet. + +Similarly, this computer program can be used to analyze the dolphins’ +language. Sure enough, we find a similar pattern indicating intelligence. +However, as we go to other mammals, the pattern begins to break down," +"and it finally collapses completely as we approach lower animals with +small brain sizes. Then the signals become nearly random. + +INTELLIGENT BEES? + +To get a sense of what alien consciousness might be like, consider the +strategies adopted by nature to reproduce life on Earth. There are two + +basic reproductive strategies nature has taken, with profound +implications for evolution and consciousness. + +The first, the strategy used by mammals, is to produce a small number +of young offspring and then carefully nurse each one to maturity. This is +a risky strategy, because only a few progeny are produced in each +generation, so it assumes that nurturing will even out the odds. This +means that every life is cherished and carefully nurtured for a length of +time." +"But there is another, much older strategy that is used by much of the +plant and animal kingdom, including insects, reptiles, and most other +life-forms on Earth. This involves creating a large number of eggs or +seeds and then letting them fend for themselves. Without nurturing, +most of the offspring never survive, so only a few hardy individuals will +make it into the next generation. This means that the energy invested in +each generation by the parents is nil, and reproduction relies on the law +of averages to propagate the species." +"These two strategies produce startlingly different attitudes toward life +and intelligence. The first strategy treasures each and every individual. +Love, nurturing, affection, and attachment are at a premium in this +group. This reproductive strategy can work only if the parents invest a +considerable amount of precious energy to preserve their young. The +second strategy, however, does not treasure the individual at all, but +rather emphasizes the survival of the species or group as a whole. To +them, individuality means nothing." +"Furthermore, reproductive strategy has profound implications for the +evolution of intelligence. When two ants meet each other, for example, +they exchange a limited amount of information using chemical scents +and gestures. Although the information shared by two ants is minimal, +with this information they are capable of creating elaborate tunnels and +chambers necessary to build an anthill. Similarly, although honeybees +communicate with one another by performing a dance, they can +collectively create complex honeycombs and locate distant flower beds. +So their intelligence arises not so much from the individual, but from the + + holistic interaction of the entire colony and from their genes. + +So consider an intelligent extraterrestrial civilization based on the +second strategy, such as an intelligent race of honeybees. In this society, +the worker bees that fly out each day in search of pollen are expendable." +"Worker bees do not reproduce at all, but instead live for one purpose, to +serve the hive and the queen, for which they willingly sacrifice +themselves. The bonds that link mammals together mean nothing to +them. + +Hypothetically, this might affect the development of their space +program. Since we treasure the life of every astronaut, considerable +resources are devoted to bringing them back alive. Much of the cost of +space travel goes into life support so the astronauts can make the return +voyage home and reenter the atmosphere. But for a civilization of +intelligent honeybees, each worker’s life may not be worth that much, so +their space program would cost considerably less. Their workers would +not have to come back. Every voyage might be a one-way trip, and that +would represent significant savings." +"Now imagine if we were to encounter an alien from space that was +actually similar to a honeybee worker. Normally, if we encounter a +honeybee in the forest, chances are it will completely ignore us, unless +we threaten it or the hive. It’s as if we did not exist. Similarly, this +worker would most likely not have the slightest interest in making +contact with us or sharing its knowledge. It would go on with its primary +mission and ignore us. Moreover, the values that we cherish would mean +little to it. + +Back in the 1970s, there were two medallions put aboard the Pioneer +10 and 11 probes, containing crucial information about our world and +society. The medallions exalted the diversity and richness of life on +Earth. Scientists back then assumed that alien civilizations in space +would be like us, curious and interested in making contact. But if such +an alien worker bee were to find our medallion, chances are that it +would mean nothing to it." +"Furthermore, each worker need not be very intelligent. They need to +be only intelligent enough to serve the interest of the hive. So if we were +to send a message to a planet of intelligent bees, chances are that they +would show little interest in sending a message back. + +Even if contact could be made with such a civilization, it might be +difficult communicating with them. For example, when we communicate +with one another, we break ideas down into sentences, with a subject- +verb structure, in order to build a narrative, often a personal story. Most + + of our sentences have the following structure: “I did this” or “They did + +that.” In fact, most of our literature and conversations use storytelling, +often involving experiences and adventures that we or our role models +have had. This presupposes that our personal experiences are the +dominant way to convey information." +"However, a civilization based on intelligent honeybees may not have +the least interest in personal narratives and storytelling. Being highly +collective, their messages may not be personal, but matter-of-fact, +containing vital information necessary for the hive rather than personal +trivia and gossip that might advance an individual’s social position. In +fact, they might find our storytelling language to be a bit repulsive, since +it puts the role of the individual before the needs of the collective. + +Also, worker bees would have a totally different sense of time. Since +worker bees are expendable, they might not have a long life span. They +might only take on projects that are short and well defined." +"However, humans live much longer, but we also have a tacit sense of +time; we take on projects and occupations that we can reasonably see to +the end within our lifetimes. We subconsciously pace our projects, our +relations with others, and our goals to accommodate a finite life span. In +other words, we live our lives in distinct phases: being single, married, +raising children, and eventually retiring. Often without being conscious +of it, we assume that we will live and eventually die within a finite time +frame." +"But imagine beings that can live for thousands of years, or are perhaps +immortal. Their priorities, their goals, and their ambitions would be +completely different. They could take on projects that would normally +require scores of human lifetimes. Interstellar travel is often dismissed as +pure science fiction because, as we have seen, the time it takes for a +conventional rocket to reach nearby stars is roughly seventy thousand +years. For us, this is prohibitively long. But for an alien life-form, that +time may be totally irrelevant. For example, they might be able to +hibernate, slow down their metabolism, or simply live for an indefinite +amount of time. + +WHAT DO THEY LOOK LIKE? + +Our first translations of these alien messages will probably give us some" +"Our first translations of these alien messages will probably give us some + + insight into the aliens’ culture and way of life. For example, it is likely +that the aliens will have evolved from predators and hence still share +some of their characteristics. (In general, predators on Earth are smarter +than prey. Hunters like tigers, lions, cats, and dogs use their cunning to +stalk, ambush, and hide, all of which require intelligence. All these +predators have eyes on the front of the face, for stereo vision as they +focus their attention. Prey, which have eyes to the sides of the face to +spot a predator, have only to run. That is why we say “sly as a fox” and +“dumb bunny.”) The alien life-forms may have outgrown many of the +predator instincts of their distant ancestors, but it is likely that they will +still have some of a predator’s consciousness (i.e., territoriality, +expansion, and violence when necessary)." +"If we examine the human race, we see that there were at least three +basic ingredients that set the stage for our becoming intelligent: + +1 . the opposable thumb, which gives us the ability to manipulate and + +reshape our environment via tools + +2. stereo eyes or the 3-D eyes of a hunter + +3. language, which allows us to accumulate knowledge, culture, and + +wisdom across generations + +When we compare these three ingredients with the traits found in the +animal kingdom, we see that very few animals meet these criteria for +intelligence. Cats and dogs, for example, do not have grasping ability or +a complex language. Octopi have sophisticated tentacles, but they don’t +see well and don’t have a complex language." +"There may be variations of these three criteria. Instead of an +opposable thumb, an alien might have claws or tentacles. (The only +prerequisite is that they should be able to manipulate their environment +with tools created by these appendages.) Instead of having two eyes, +they may have many more, like insects. Or they may have sensors that +detect sound or UV light rather than visible light. More than likely, they +will have the stereo eyes of a hunter, because predators generally have a +higher level of intelligence than prey. Also, instead of a language based +on sounds, they may communicate via different forms of vibrations. (The +only requirement is that they exchange information among themselves to + +create a culture spanning many generations.) + +But beyond these three criteria, anything goes." +"Next, the aliens may have a consciousness colored by their +environment. Astronomers now realize that the most plentiful habitat for +life in the universe may not be earthlike planets, where they can bask in +the warm sunlight of the mother star, but on icy-cold satellites orbiting +Jupiter-size planets billions of miles from the star. It is widely believed +that Europa, an ice-covered moon of Jupiter, has a liquid ocean beneath +the icy surface, heated by tidal forces. Because Europa tumbles as it +orbits Jupiter, it is squeezed in different directions by the huge +gravitational pull of Jupiter, which causes friction deep inside the moon. +This generates heat, forming volcanoes and ocean vents that melt the ice +and create liquid oceans. It is estimated that the oceans of Europa are +quite deep, and that their volume may be many times the volume of the +oceans of Earth. Since 50 percent of all stars in the heavens may have +Jupiter-size planets (a hundred times more plentiful than earthlike" +"Jupiter-size planets (a hundred times more plentiful than earthlike +planets), the most plentiful form of life may be on the icy moons of gas +giants like Jupiter." +"Therefore, when we encounter our first alien civilization in space, +more than likely it will have an aquatic origin. (Also, it is likely that +they will have migrated from the ocean and learned to live on the icy +surface of their moon away from the water, for several reasons. First, +any species that lives perpetually under the ice will have a quite limited +view of the universe. They will never develop astronomy or a space +program if they think that the universe is just the ocean underneath the +ice cover. Second, because water short-circuits electrical components, +they will never develop radio or TV if they stay underwater. If this +civilization is to advance, it must master electronics, which cannot exist +in the oceans. So, most likely, these aliens will have learned to leave the +oceans and survive on the land, as we did.)" +"But what happens if this life-form evolves to create a space-faring +civilization, capable of reaching Earth? Will they still be biological +organisms like us, or will they be post-biological? + +THE POST-BIOLOGICAL ERA + +One person who has spent considerable time thinking about these +questions is my colleague Dr. Paul Davies of Arizona State University, +near Phoenix. When I interviewed him, he told me that we have to +expand our own horizon to contemplate what a civilization that is +thousands or more years ahead of us may look like. + +Given the dangers of space travel, he believes that such beings will +have abandoned their biological form, much like the bodiless minds we +considered in the previous chapter. He writes, “My conclusion is a +startling one. I think it very likely—in fact inevitable—that biological" +"intelligence is only a transitory phenomenon, a fleeting phase in the +evolution of intelligence in the universe. If we ever encounter +extraterrestrial intelligence, I believe it is overwhelmingly likely to be +post-biological in nature, a conclusion that has obvious and far-reaching +ramifications for SETI.” + +In fact, if the aliens are thousands of years ahead of us, chances are +that they have abandoned their biological bodies eons ago to create the +most efficient computational body: a planet whose entire surface is +completely covered with computers. Dr. Davies says, “It isn’t hard to +envision the entire surface of a planet being covered with a single +integrated processing system.... Ray Bradbury has coined the term +‘Matrioshka brains’ for these awesome entities.”" +"So to Dr. Davies, alien consciousness may lose the concept of “self” +and be absorbed into the collective World Wide Web of Minds, which +blankets the entire surface of the planet. Dr. Davies adds, “A powerful +computer network with no sense of self would have an enormous +advantage over human intelligence because it could redesign ‘itself,’ +fearlessly make changes, merge with whole systems, and grow. ‘Feeling +personal’ about it would be a distinct impediment to progress.” + +So in the name of efficiency and increased computational ability, he +envisions members of this advanced civilization giving up their identity +and being absorbed into a collective consciousness. + +Dr. Davies acknowledges that critics of his idea may find this concept +rather repulsive. It appears as if this alien species is sacrificing +individuality and creativity to the greater good of the collective or the +hive. This is not inevitable, he cautions, but it is the most efficient +option for civilization." +"Dr. Davies also has a conjecture that he admits is rather depressing. + +When I asked him why these civilizations don’t visit us, he gave me a +strange answer. He said that any civilization that advanced would also +have developed virtual realities far more interesting and challenging +than reality. The virtual reality of today would be a children’s toy +compared to the virtual reality of a civilization thousands of years more +advanced than us. + +This means that perhaps their finest minds might have decided to play +out imaginary lives in different virtual worlds. It’s a discouraging +thought, he admitted, but certainly a possibility. In fact, it might even be +a warning for us as we perfect virtual reality. + + WHAT DO THEY WANT?" +"WHAT DO THEY WANT? + +In the movie The Matrix, the machines take over and put humans into +pods, where they exploit us as batteries to energize themselves. That is +why they keep us alive. But since a single electrical plant produces more +power than the bodies of millions of humans, any alien looking for an +energy source would quickly see there is no need for human batteries. +(This seems to be lost on the machine overlords in the Matrix, but +hopefully aliens would see reason.)" +"Another possibility is that they might want to eat us. This was +explored in an episode of The Twilight Zone, in which aliens land on +Earth and promise us the benefits of their advanced technology. They +even ask for volunteers to visit their beautiful home planet. The aliens +accidentally leave behind a book, called To Serve Man, which scientists +anxiously try to decipher in order to discover what wonders the aliens +will share with us. Instead, the scientists find out that the book is +actually a cookbook. (But since we will be made of entirely different +DNA and proteins from theirs, we could be difficult for their digestive +tracts to process.)" +"Another possibility is that the aliens will want to strip Earth of +resources and valuable minerals. There may be some truth to this +argument, but if the aliens are advanced enough to travel effortlessly +from the stars, then there are plenty of uninhabited planets to plunder +for resources, without having to worry about restive natives. From their +point of view, it would be a waste of time to try to colonize an inhabited + +planet when there are easy alternatives." +"planet when there are easy alternatives. + +So if the aliens do not want to enslave us or plunder our resources, +then what danger do they pose? Think of deer in a forest. Whom should +they fear the most—the ferocious hunter armed with a shotgun, or the +mild-mannered developer armed with a blueprint? Although the hunter +may scare the deer, only a few deer are threatened by him. More +dangerous to the deer is the developer, because the deer are not even on +his radar screen. The developer may not even think about the deer at all, +concentrating instead on developing the forest into usable property. In +view of this, what would an invasion actually look like?" +"In Hollywood movies, there is one glaring flaw: the aliens are only a +century or so ahead of us, so we can usually devise a secret weapon or +exploit a simple weakness in their armor to fight them off, as in Earth vs. +the Flying Saucers. But as SETI director Dr. Seth Shostak once told me, a +battle with an advanced alien civilization will be like a battle between +Bambi and Godzilla. + + In reality, the aliens might be millennia to millions of years ahead of +us in their weaponry. So, for the most part, there will be little we can do +to defend ourselves. But perhaps we can learn from the barbarians who +defeated the greatest military empire of its time, the Roman Empire. + +The Romans were masters of engineering, able to create weapons that +could flatten barbarian villages and roads to supply distant military +outposts of a vast empire. The barbarians, who were barely emerging +from a nomadic existence, had little chance when encountering the +juggernaut of the Roman Imperial Army." +"But history records that as the empire expanded, it was spread too +thin, with too many battles to fight, too many treaties bogging it down, +and not enough of an economy to support all this, especially with a +gradual decline in population. Moreover, the empire, always short on +recruits, had to enlist young barbarian soldiers and promote them to +leadership positions. Inevitably, the superior technology of the empire +began to filter down to the barbarians as well. In time, the barbarians +began to master the very military technologies that at first had +conquered them. + +Toward the end, the empire, weakened by internal palace intrigues, +severe crop shortages, civil wars, and an overstretched army, faced +barbarians who were able to fight the Roman Imperial Army to a + +standstill. The sacking of Rome in A.D. 410 and 455 paved the way for +the empire’s ultimate fall in A.D. 476." +"In the same way, it is likely that earthlings will initially offer no real +threat to an alien invasion, but over time earthlings could learn the weak +points of the alien army, its power supplies, its command centers, and +most of all its weaponry. In order to control the human population, the +aliens will have to recruit collaborators and promote them. This will +result in a diffusion of their technology to the humans. + +Then a ragtag army of earthlings might be able to mount a +counterattack. In Eastern military strategy, like the classic teachings of +Sun Tzu in The Art of War, there is a way to defeat even a superior army. +You first allow it to enter your territory. Once it has entered unfamiliar +land and its ranks are diffused, you can counterattack where they are +weakest." +"Another technique is to use the enemy’s strength against it. In judo, +the principal strategy is to turn the momentum of the attacker to your +advantage. You let the enemy attack, and then trip them or throw them +off guard, exploiting the enemy’s own mass and energy. The bigger they + + are, the harder they fall. In the same way, perhaps the only way to fight +a superior alien army is to allow it to invade your territory, learn its +weaponry and military secrets, and turn those very weapons and secrets +against it. + +So a superior alien army cannot be defeated head-on. But it will +withdraw if it cannot win and the cost of a stalemate is too high. Success +means depriving the enemy of a victory." +"But more than likely, I believe the aliens will be benevolent and, for +the most part, ignore us. We simply have nothing to offer them. If they +visit us, then it will be mainly out of curiosity or for reconnaissance. +(Since curiosity was an essential feature in our becoming intelligent, it is +likely that any alien species will be curious, and hence want to analyze +us, but not necessarily to make contact.) + +MEETING AN ALIEN ASTRONAUT + +Unlike in the movies, we will probably not meet the flesh-and-blood +alien creatures themselves. It would simply be too dangerous and + +unnecessary. In the same way that we sent the Mars Rover to explore, +aliens will more than likely send organic/mechanical surrogates or +avatars instead, which can better handle the stresses of interstellar +travel. In this way, the “aliens” we meet on the White House lawn may +look nothing like their masters back on the home planet. Instead, the +masters will project their consciousness into space through proxies." +"More than likely, though, they will send a robotic probe to our moon, +which is geologically stable, with no erosion. These probes are self- +replicating; that is, they will create a factory and manufacture, say, a +thousand copies of themselves. (These are called von Neumann probes, +after mathematician John von Neumann, who laid the foundation for +digital computers. Von Neumann was the first mathematician to +seriously consider the problem of machines that could reproduce +themselves.) These second-generation probes are then launched to other +star systems, where each one in turn creates a thousand more third- +generation probes, making a total of a million. Then these probes fan out +and create more factories, making a billion probes. Starting with just one +probe, we have one thousand, then a million, then a billion. Within five +generations, we have a quadrillion probes. Soon we have a gigantic +sphere, expanding at near light speed, containing trillions upon trillions" +"sphere, expanding at near light speed, containing trillions upon trillions +of probes, colonizing the entire galaxy within a few hundred thousand +years." +"Dr. Davies takes this idea of self-replicating von Neumann probes so +seriously that he has actually applied for funding to search the surface of +the moon for evidence of a previous alien visitation. He wishes to scan +the moon for radio emissions or radiation anomalies that would indicate +evidence of an alien visitation, perhaps millions of years ago. He wrote a +paper with Dr. Robert Wagner in the scientific journal Acta Astronautica +calling for a close examination of the photos from the Lunar +Reconnaissance Orbiter down to a resolution of about 1.5 feet." +"They wrote, “Although there is only a tiny probability that alien +technology would have left traces on the moon in the form of an artifact +or surface modification of lunar features, this location has the virtue of +being close,” and also traces of an alien technology would remain +preserved over long periods of time. Since there is no erosion on the +moon, treadmarks left by aliens would still be visible (in the same way +that footprints left by our astronauts in the 1970s could, in principle, last + +for billions of years). + +One problem is that the von Neumann probe might be very small. +Nanoprobes use molecular machines and MEMs, and hence it might be +only as big as a bread box, he said to me, or even smaller. (In fact, if +such a probe landed on Earth in someone’s backyard, the owner might +not even notice.)" +"This method, however, represents the most efficient way of colonizing +the galaxy, using the exponential growth of self-replicating von +Neumann probes. (This is also the way in which a virus infects our body. +Starting with a handful of viruses, they land on our cells, hijack the +reproductive machinery, and convert our cells into factories to create +more viruses. Within two weeks, a single virus can infect trillions of +cells, and we eventually sneeze.)" +"If this scenario is correct, it means that our own moon is the most +likely place for an alien visitation. This is also the basis of the movie +2001: A Space Odyssey, which even today represents the most plausible +encounter with an extraterrestrial civilization. In the movie, a probe was +placed on our moon millions of years ago, mainly to observe the +evolution of life on Earth. At times, it interferes in our evolution and +gives us an added boost. This information is then sent to Jupiter, which +is a relay station, before heading to the home planet of this ancient alien +civilization. + +From the point of view of this advanced civilization, which can +simultaneously scan billions of star systems, we can see that they have a +considerable choice in what planetary systems to colonize. Given the +sheer enormity of the galaxy, they can collect data and then best choose + + which planets or moons would yield the best resources. From their +perspective, they might not find Earth very appealing." +"The empires of the future will be empires of the mind. + +—WINSTON CHURCHILL + +If we continue to develop our technology without wisdom +prudence, our servant may prove to be our executioner. + +—GENERAL OMAR BRADLEY + +15 CONCLUDING REMARKS + +In 2000, a raging controversy erupted in the scientific community. +One of the founders of Sun Computers, Bill Joy, wrote an inflammatory +article denouncing the mortal threat we face from advanced technology. +In an article in Wired magazine with the provocative title “The Future +Does Not Need Us,” he wrote, “Our most powerful 21st century +technologies—robotics, genetic engineering, and nanotech—are +threatening to make humans an endangered species.” That incendiary +article questioned the very morality of hundreds of dedicated scientists +toiling in their labs on the cutting edge of science. He challenged the +very core of their research, stating that the benefits of these technologies +were vastly overshadowed by the enormous threats they posed to +humanity." +"He described a macabre dystopia in which all our technologies +conspire to destroy civilization. Three of our key creations will +eventually turn on us, he warned: + +• One day, bioengineered germs may escape from the laboratory and +wreak havoc on the world. Since you cannot recapture these life- +forms, they might proliferate wildly and unleash a fatal plague on +the planet worse than those of the Middle Ages. Biotechnology may +even alter human evolution, creating “several separate and unequal +species ... that would threaten the notion of equality that is the very +cornerstone of our democracy.” + +• One day, nanobots may go berserk and spew out unlimited +quantities of “gray goo,” which will blanket Earth, smothering all +life. Since these nanobots “digest” ordinary matter and create new +forms of matter, malfunctioning nanobots could run amok and" +"digest much of Earth. “Gray goo would surely be a depressing +ending to our human adventure on Earth, far worse than mere fire +or ice, and one that could stem from a simple laboratory accident. + +Oops,” he wrote. + +• One day, the robots will take over and replace humanity. They will +become so intelligent that they will simply push humanity aside. We +will be left as an evolutionary footnote. “The robots would in no +sense be our children.... On this path our humanity may well be +lost,” he wrote." +"Joy claimed that the dangers unleashed by these three technologies +dwarfed the dangers posed by the atomic bomb in the 1940s. Back then, +Einstein warned of the power of nuclear technology to destroy +civilization: “It has become appallingly obvious that our technology has +exceeded our humanity.” But the atomic bomb was built by a huge +government program that could be tightly regulated, while these +technologies are being developed by private companies that are lightly +regulated, if at all, Joy pointed out. + +Sure, he conceded, these technologies may alleviate some suffering in +the short term. But in the long term, the benefits are overwhelmed by +the fact that they may unleash a scientific Armageddon that may doom +the human race." +"Joy even accused scientists of being selfish and naive as they try to +create a better society. He wrote, “A traditional utopia is a good society +and a good life. A good life involves other people. This techno utopia is +all about ‘I don’t get diseases; I don’t die; I get to have better eyesight +and be smarter’ and all this. If you described this to Socrates or Plato, +they would laugh at you.” + +He concluded by stating, “I think it is no exaggeration to say we are +on the cusp of the further perfection of extreme evil, an evil whose +possibility spreads well beyond that which weapons of mass destruction +bequeathed to the nation-states....” + +The conclusion to all this? “Something like extinction,” he warned. + +As expected, the article sparked a firestorm of controversy." +"As expected, the article sparked a firestorm of controversy. + +That article was written over a decade ago. In terms of high +technology, that is a lifetime. It is now possible to view certain of its +predictions with some hindsight. Looking back at the article and putting +his warnings into perspective, we can easily see that Bill Joy exaggerated +many of the threats coming from these technologies, but he also spurred + + scientists to face up to the ethical, moral, and societal consequences of + +their work, which is always a good thing. + +And his article opened up a discussion about who we are. In +unraveling the molecular, genetic, and neural secrets of the brain, +haven’t we in some sense dehumanized humanity, reducing it to a +bucket of atoms and neurons? If we completely map every neuron of the +brain and trace every neural pathway, doesn’t that remove the mystery +and magic of who we are? + +A RESPONSE TO BILL JOY" +"A RESPONSE TO BILL JOY + +In retrospect, the threats from robotics and nanotechnology are more +distant than Bill Joy thought, and I would argue that with enough +warning, we can take a variety of countermeasures, such as banning +certain avenues of research if they lead to uncontrollable robots, placing +chips in them to shut them off if they become dangerous, and creating +fail-safe devices to immobilize all of them in an emergency. + +More immediate is the threat from biotechnology, where there is the +realistic danger of biogerms that might escape the laboratory. In fact, +Ray Kurzweil and Bill Joy jointly wrote an article criticizing the +publication of the complete genome of the 1918 Spanish flu virus, one of +the most lethal germs in modern history, which killed more people than +World War I. Scientists were able to reassemble the long-dead virus by +examining the corpses and blood of its victims and sequencing its genes, +and then they published it on the web." +"Safeguards already exist against the release of such a dangerous virus, +but steps must be taken to further strengthen them and add new layers +of security. In particular, if a new virus suddenly erupts in some distant +place on Earth, scientists must strengthen rapid-response teams that can +isolate the virus in the wild, sequence its genes, and then quickly +prepare a vaccine to prevent its spread. + +IMPLICATIONS FOR THE FUTURE OF THE MIND + +This debate also has a direct impact on the future of the mind. At +present, neuroscience is still rather primitive. Scientists can read and +videotape simple thoughts from the living brain, record a few memories, + + connect the brain to mechanical arms, enable locked-in patients to +control machines around them, silence specific regions of the brain via +magnetism, and identify the regions of the brain that malfunction in +mental illness." +"In the coming decades, however, the power of neuroscience may +become explosive. Current research is on the threshold of new scientific +discoveries that will likely leave us breathless. One day, we might +routinely control objects around us with the power of the mind, +download memories, cure mental illness, enhance our intelligence, +understand the brain neuron by neuron, create backup copies of the +brain, and communicate with one another telepathically. The world of +the future will be the world of the mind." +"Bill Joy did not dispute the potential of this technology to relieve +human suffering and pain. But what made him look on it with horror +was the prospect of enhanced individuals who might cause the human +species to split apart. In the article, he painted a dismal dystopia in +which only a tiny elite have their intelligence and mental processes +enhanced, while the masses of people live in ignorance and poverty. He +worried that the human race would fission in two, or perhaps cease to be +human at all. + +But as we have pointed out, almost all technologies when they are first +introduced are expensive and hence exclusively for the well-off. Because +of mass production, the falling cost of computers, competition, and +cheaper shipping, technologies inevitably filter down to the poor as well. +This was also the trajectory taken by phonographs, radio, TV, PCs, +laptops, and cell phones." +"Far from creating a world of haves and have-nots, science has been the +engine of prosperity. Of all the tools that humanity has harnessed since +the dawn of time, by far the most powerful and productive has been +science. The incredible wealth we see all around us is directly due to +science. To appreciate how technology reduces, rather than accentuates, +societal fault lines, consider the lives of our ancestors around 1900. Life +expectancy in the United States back then was forty-nine years. Many +children died in infancy. Communicating with a neighbor involved +yelling out the window. The mail was delivered by horse, if it came at +all. Medicine was largely snake oil. The only treatments that actually +worked were amputations (without anesthetics) and morphine to deaden + +the pain. Food rotted within days. Plumbing was nonexistent. Disease +was a constant threat. And the economy could support only a handful of +the rich and a tiny middle class." +"Technology has changed everything. We no longer have to hunt for +our food; we simply go to the supermarket. We no longer have to carry +back-breaking supplies but instead simply get into our cars. (In fact, the +main threat we face from technology, one that has killed millions of +people, is not murderous robots or mad nanobots run amok—it’s our +indulgent lifestyle, which has created near-epidemic levels of diabetes, +obesity, heart disease, cancer, etc. And this problem is self-inflicted.) + +We also see this on the global level. In the last few decades the world +has witnessed hundreds of millions of people being lifted out of grinding +poverty for the first time in history. If we view the bigger picture, we see +that a significant fraction of the human race has left the punishing +lifestyle of sustenance farming and entered the ranks of the middle class." +"It took several hundred years for Western nations to industrialize, yet +China and India are doing it within a few decades, all due to the spread +of high technology. With wireless technology and the Internet, these +nations can leapfrog past other, more developed nations that have +laboriously wired their cities. While the West struggles with an aging, +decaying urban infrastructure, developing nations are building entire +cities with sparkling, state-of-the-art technology." +"(When I was a graduate student getting my Ph.D., my counterparts in +China and India would have to wait several months to a year for +scientific journals to come in the mail. Plus, they had almost no direct +contact with scientists and engineers in the West, because few if any +could afford to travel here. This vastly impeded the flow of technology, +which moved at a glacial pace for these nations. Today, however, +scientists can read one another’s papers as soon as they are posted on the +Internet, and can electronically collaborate with other scientists around +the world. This has vastly accelerated the flow of information. And with +this technology comes progress and prosperity.)" +"Furthermore, it’s not clear that having some form of enhanced +intelligence will cause a catastrophic splitting of the human race, even if +many people are unable to afford this procedure. For the most part, +being able to solve complex mathematical equations or have perfect +recall does not guarantee a higher income, respect from your peers, or + +more popularity with the opposite sex, which are the incentives that +motivate most people. The Caveman Principle trumps having a brain +boost. + +As Dr. Michael Gazzaniga notes, “The idea that we are messin’ with +our innards is disturbing to many. And just what would we do with +expanded intelligence? Are we going to use it for solving problems, or +will it just allow us to have longer Christmas card lists ...?”" +"But as we discussed in Chapter 5, unemployed workers may benefit +from this technology, drastically reducing the time required to master +new technologies and skills. This might not only reduce the problems +associated with unemployment, it could also have an impact on the +world economy, making it more efficient and responsive to change. + +WISDOM AND DEMOCRATIC DEBATE + +In responding to Joy’s article, some critics pointed out that the debate is +not about a struggle between scientists and nature, as portrayed in the +article. The debate is actually between three parties: scientists, nature, +and society." +"Computer scientists Drs. John Brown and Paul Duguid responded to +the article by stating, “Technologies—such as gunpowder, the printing +press, the railroad, the telegraph, and the Internet—can change society +in profound ways. But on the other hand, social systems—in the form of +governments, the courts, formal and informal organizations, social +movements, professional networks, local communities, market +institutions, and so forth—shape, moderate, and redirect the raw power +of technologies.” + +The point is to analyze them in terms of society, and ultimately it is up +to us to adopt a new vision of the future that incorporates all the best +ideas. + +To me, the ultimate source of wisdom in this respect comes from +vigorous democratic debate. In the coming decades, the public will be +asked to vote on a number of crucial scientific issues. Technology cannot +be debated in a vacuum. + +PHILOSOPHICAL QUESTIONS" +"PHILOSOPHICAL QUESTIONS + +Lastly, some critics have claimed that the march of science has gone too +far in unveiling the secrets of the mind, an unveiling that has become +dehumanizing and degrading. Why bother to rejoice at discovering +something new, learning a new skill, or enjoying a leisurely vacation +when it can all be reduced to a few neurotransmitters activating a few +neural circuits? + +In other words, just as astronomy has reduced us to insignificant +pieces of cosmic dust floating in an uncaring universe, neuroscience has +reduced us to electrical signals circulating within neural circuits. But is +this really true?" +"We began our discussion by highlighting the two greatest mysteries in +all of science: the mind and the universe. Not only do they have a +common history and narrative, they also share a similar philosophy and +perhaps even destiny. Science, with all its power to peer into the heart of +black holes and land on distant planets, has given birth to two +overarching philosophies about the mind and the universe: the +Copernican Principle and the Anthropic Principle. Both are consistent +with everything known about science, but they are diametrical +opposites. + +The first great philosophy, the Copernican Principle, was born with +the discovery of the telescope more than four hundred years ago. It +states that there is no privileged position for humanity. Such a +deceptively simple idea has overthrown thousands of years of cherished +myths and entrenched philosophies." +"Ever since the biblical tale of Adam and Eve being exiled from the +Garden of Eden for biting into the Apple of Knowledge, there has been a +series of humiliating dethronements. First, the telescope of Galileo +clearly showed that Earth was not the center of the solar system—the +sun was. This picture was then overthrown when it was realized that the +solar system was just a speck in the Milky Way galaxy circulating about +thirty thousand light-years from the center. Then in the 1920s, Edwin +Hubble discovered there was a multitude of galaxies. The universe +suddenly got billions of times bigger. Now the Hubble Space Telescope +can reveal the presence of up to one hundred billion galaxies in the +visible universe. Our own Milky Way galaxy has been reduced to a +pinpoint in a much larger cosmic arena. + +More recent cosmological theories further downgrade the position of" +"More recent cosmological theories further downgrade the position of + +humanity in the universe. The inflationary universe theory states that +our visible universe, with its one hundred billion galaxies, is just a +pinprick on a much larger, inflated universe that is so big that most light +has not had time to reach us yet from distant regions. There are vast +reaches of space that we cannot see with our telescopes and will never +be able to visit because we cannot go faster than light. And if string +theory (my specialty) is correct, it means that even the entire universe +coexists with other universes in eleven-dimensional hyperspace. So even +three-dimensional space is not the final word. The true arena for +physical phenomena is the multiverse of universes, full of floating +bubble universes. + +The science-fiction writer Douglas Adams tried to summarize the sense +of being constantly overthrown by inventing the Total Perspective +Vortex in The Hitchhiker’s Guide to the Galaxy. It was designed to drive" +"any sane person insane. When you enter the chamber, all you see is a +gigantic map of the entire universe. And on the map there is a tiny, +almost invisible arrow that says, “You are here.” + +So on one hand, the Copernican Principle indicates that we are just +insignificant cosmic debris drifting aimlessly among the stars. But on the +other hand, all the latest cosmological data are consistent with yet +another theory, which gives us the opposite philosophy: the Anthropic +Principle. + +This theory states that the universe is compatible with life. Again, this +deceptively simple statement has profound implications. On one hand, it +is impossible to dispute that life exists in the universe. But it’s clear that +the forces of the universe must be calibrated to a remarkable degree to +make life possible. As physicist Freeman Dyson once said, “The universe +seemed to know that we were coming.”" +"For example, if the nuclear force were just a bit stronger, the sun +would have burned out billions of years ago, too soon to allow DNA to +get off the ground. If the nuclear force were a bit weaker, then the sun +would never have ignited to begin with, and we still would not be here. + +Likewise, if gravity were stronger, the universe would have collapsed +into a Big Crunch billions of years ago, and we would all be roasted to +death. If it were a bit weaker, then the universe would have expanded so +fast it would have reached the Big Freeze, so we would all have frozen to +death. + +This fine-tuning extends to every atom of the body. Physics says that +we are made of star dust, that the atoms we see all around us were +forged in the heat of a star. We are literally children of the stars." +"But the nuclear reactions that burned hydrogen to create the higher +elements of our body are very complex and could have been derailed at +any number of points. Then it would have been impossible to create the +higher elements of our bodies, and the atoms of DNA and life would not +exist. + +In other words, life is precious and a miracle. + +There are so many parameters that have to be fine-tuned that some +claim this is not a coincidence. The weak form of the Anthropic Principle +implies that the existence of life forces the physical parameters of the +universe to be defined in a very precise way. The strong form of the +Anthropic Principle goes even further, stating that God or some designer +had to create a universe “just right” to make life possible. + + PHILOSOPHY AND NEUROSCIENCE" +"PHILOSOPHY AND NEUROSCIENCE + +The debate between the Copernican Principle and the Anthropic +Principle also resonates in neuroscience. For example, some claim that +humans can be reduced to atoms, molecules, and neurons, and hence +there is no distinguished place for humanity in the universe. + +Dr. David Eagleman writes, “The you that all your friends know and +love cannot exist unless the transistors and screws of our brain are in +place. If you don’t believe this, step into any neurology ward in any +hospital. Damage to even small parts of the brain can lead to the loss of +shockingly specific abilities; the ability to name animals, or to hear +music, or to manage risky behavior, or to distinguish colors, or to +arbitrate simple decisions.” + +It seems that the brain cannot function without all its “transistors and +screws.” He concludes, “Our reality depends on what our biology is up +to.”" +"So on one hand, our place in the universe seems to be diminished if +we can be reduced, like robots, to (biological) nuts and bolts. We are just +wetware, running software called the mind, nothing more or less. Our +thoughts, desires, hopes, and aspirations can be reduced to electrical + +impulses circulating in some region of the prefrontal cortex. That is the +Copernican Principle applied to the mind. + +But the Anthropic Principle can also be applied to the mind, and we +then reach the opposite conclusion. It simply says that conditions of the +universe make consciousness possible, even though it is extraordinarily +difficult to create the mind out of random events. The great Victorian +biologist Thomas Huxley said, “How it is that anything so remarkable as +a state of consciousness comes about as a result of irritating nervous +tissue, is just as unaccountable as the appearance of the Djinn, when +Aladdin rubbed his lamp.”" +"Furthermore, most astronomers believe that although one day we may +find life on other planets, it will most likely be microbial life, which +ruled our oceans for billions of years. Instead of seeing great cities and +empires, we might only find oceans of drifting microorganisms. + +When I interviewed the late Harvard biologist Stephen Jay Gould +about this, he explained to me his thinking as follows. If we were to +somehow create a twin of Earth as it was 4.5 billion years ago, would it +turn out the same way 4.5 billion years later? Most likely not. There is a + + large probability that DNA and life would never have gotten off the +ground, and an even larger probability that intelligent life with +consciousness would never have risen from the swamp." +"Gould wrote, “Homo sapiens is one small twig [on the tree of life]. +... Yet our twig, for better or worse, has developed the most +extraordinary new quality in all the history of multicellular life since the +Cambrian explosion (500 million years ago). We have invented +consciousness with all its sequelae from Hamlet to Hiroshima.”" +"In fact, in the history of Earth, there are many times when intelligent +life was almost extinguished. In addition to the mass extinctions that +wiped out the dinosaurs and most life on Earth, humans have faced +additional near extinctions. For example, humans are all genetically +related to one another to a considerable degree, much closer than two +typical animals of the same species. Although humans may look diverse +from the outside, our genes and internal chemistry tell a different story. +In fact, any two humans are so closely related genetically that we can +actually do the math and calculate when a “genetic Eve” or “genetic +Adam” gave birth to the entire human race. Moreover, we can calculate +how many of us there were in the past." +"The numbers are remarkable. Genetics shows that there were only a +few hundred to a few thousand humans alive about seventy to one +hundred thousand years ago and that they gave birth to the entire +human race. (One theory holds that the titanic explosion of the Toba +volcano in Indonesia about seventy thousand years ago caused +temperatures to drop so dramatically that most of the human race +perished, leaving only a handful to populate Earth.) From that small +band of humans came the adventurers and explorers who would +eventually colonize the entire planet. + +Repeatedly in the history of Earth, intelligent life might have come to +a dead end. It is a miracle we survived. We can also conclude that +although life may exist on other planets, conscious life may exist on only +a tiny fraction of them. So we should treasure the consciousness that is +found on Earth. It is the highest form of complexity known in the +universe, and probably also the rarest." +"Sometimes, when contemplating the future destiny of the human race, +I have to come to grips with the distinct possibility of its self-destruction. +Although volcanic eruptions and earthquakes could spell doom for the +human race, our worst fears may be realized through man-made +disasters, such as nuclear wars or bioengineered germs. If so, then +perhaps the only conscious life-form in this sector of the Milky Way +galaxy might be extinguished. This, I feel, would be a tragedy not just +for us, but for the universe as well. We take for granted that we are + + conscious, but we don’t understand the long, tortuous sequence of +biological events that have transpired to make this possible. Psychologist +Steven Pinker writes, “I would argue that nothing gives life more +purpose than the realization that every moment of consciousness is a +precious and fragile gift.” + +THE MIRACLE OF CONSCIOUSNESS" +"THE MIRACLE OF CONSCIOUSNESS + +Lastly, there is the criticism of science that says to understand something +is to remove its mystery and magic. Science, by lifting the veil +concealing the secrets of the mind, is also making it more ordinary and +mundane. However, the more I learn about the sheer complexity of the +brain, the more amazed I am that something that sits on our shoulders is + +the most sophisticated object we know about in the universe. As Dr. +David Eagleman says, “What a perplexing masterpiece the brain is, and +how lucky we are to be in a generation that has the technology and the +will to turn our attention to it. It is the most wondrous thing we have +discovered in the universe, and it is us.” Instead of diminishing the sense +of wonder, learning about the brain only increases it. + +More than two thousand years ago, Socrates said, “To know thyself is +the beginning of wisdom.” We are on a long journey to complete his +wishes. + +APPENDIX + +QUANTUM CONSCIOUSNESS?" +"APPENDIX + +QUANTUM CONSCIOUSNESS? + +In spite of all the miraculous advances in brain scans and high +technology, some people claim that we will never understand the secret +of consciousness, since consciousness is beyond our puny technology. In +fact, in their view consciousness is more fundamental than atoms, +molecules, and neurons and determines the nature of reality itself. To +them, consciousness is the fundamental entity out of which the material +world is created. And to prove their point, they refer to one of the +greatest paradoxes in all of science, which challenges our very definition +of reality: the Schrodinger’s Cat paradox. Even today, there is no +universal consensus on the question, with Nobel laureates taking +divergent stances. What is at stake is nothing less than the nature of +reality and thought." +"The Schrodinger’s Cat paradox cuts to the very foundation of quantum +mechanics, a field that makes lasers, MRI scans, radio and TV, modern +electronics, the GPS, and telecommunications possible, upon which the +world economy depends. Many of quantum theory’s predictions have +been tested to an accuracy of one part in one hundred billion. + +I have spent my entire professional career working on the quantum +theory. Yet I realize that it has feet of clay. It’s an unsettling feeling +knowing my life’s work is based on a theory whose very foundation is +based on a paradox." +"This debate was sparked by Austrian physicist Erwin Schrodinger, who +was one of the founding fathers of the quantum theory. He was trying to +explain the strange behavior of electrons, which seemed to exhibit both +wave and particle properties. How can an electron, a point particle, have +two divergent behaviors? Sometimes electrons acted like a particle, +creating well-defined tracks in a cloud chamber. Other times, electrons +acted like a wave, passing through tiny holes and creating wavelike +interference patterns, like those on the surface of a pond. + +In 1925, Schrodinger put forward his celebrated wave equation, which" +"In 1925, Schrodinger put forward his celebrated wave equation, which + +bears his name and is one of the most important equations ever written. +It was an instant sensation, and won him the Nobel Prize in 1933. The +Schrodinger equation accurately described the wavelike behavior of +electrons and, when applied to the hydrogen atom, explained its strange +properties. Miraculously, it could also be applied to any atom and +explain most of the features of the periodic table of elements. It seemed +as if all chemistry (and hence all biology) were nothing but solutions of +this wave equation. Some physicists even claimed that the entire +universe, including all the stars, planets, and even us, was nothing but a +solution of this equation. + +But then physicists began to ask a problematic question that resonates +even today: If the electron is described by a wave equation, then what is +waving?" +"In 1927, Werner Heisenberg proposed a new principle that split the +physics community down the middle. Heisenberg’s celebrated +uncertainty principle states that you cannot know both the location and +the momentum of an electron with certainty. This uncertainty was not a +function of how crude your instruments were but was inherent in +physics itself. Even God or some celestial being could not know the +precise location and momentum of an electron. + +So the wave function of Schrodinger actually described the probability +of finding the electron. Scientists had spent thousands of years painfully + + trying to eliminate chance and probabilities in their work, and now +Heisenberg was allowing it in through the back door. + +The new philosophy can be summed up as follows: the electron is a +point particle, but the probability of finding it is given by a wave. And +this wave obeys Schrodinger’s equation and gives rise to the uncertainty +principle." +"The physics community cracked in half. On one side, we had +physicists like Niels Bohr, Werner Heisenberg, and most atomic +physicists eagerly adopting this new formulation. Almost daily, they +were announcing new breakthroughs in understanding the properties of +matter. Nobel Prizes were being handed out to quantum physicists like +Oscars. Quantum mechanics was becoming a cookbook. You did not +need to be a master physicist to make stellar contributions—you just +followed the recipes given by quantum mechanics and you would make +stunning breakthroughs. + +On the other side, we had aging Nobel laureates like Albert Einstein, +Erwin Schrodinger, and Louis de Broglie who were raising philosophical +objections. Schrodinger, whose work helped start this whole process, +grumbled that if he had known that his equation would introduce +probability into physics, he would never have created it in the first +place." +"Physicists embarked on an eighty-year debate that continues even +today. On one hand, Einstein would proclaim that “God does not play +dice with the world.” Niels Bohr, on the other hand, reportedly replied, +“Stop telling God what to do.” + +In 1935, to demolish the quantum physicists once and for all, +Schrodinger proposed his celebrated cat problem. Place a cat in a sealed +box, with a container of poison gas. In the box, there is a lump of +uranium. The uranium atom is unstable and emits particles that can be +detected by a Geiger counter. The counter triggers a hammer, which falls +and breaks the glass, releasing the gas, which can kill the cat." +"How do you describe the cat? A quantum physicist would say that the +uranium atom is described by a wave, which can either decay or not +decay. Therefore you have to add the two waves together. If the uranium +fires, then the cat dies, so that is described by one wave. If the uranium +does not fire, then the cat lives, and that is also described by a wave. To +describe the cat, you therefore have to add the wave of a dead cat to the +wave of a live cat. + +This means that the cat is neither dead nor alive! The cat is in a +netherworld, between life and death, the sum of the wave describing a + + dead cat with the wave of a live cat. + +This is the crux of the problem, which has reverberated in the halls of +physics for almost a century. So how do you resolve this paradox? There +are at least three ways (and hundreds of variations on these three)." +"The first is the original Copenhagen interpretation proposed by Bohr +and Heisenberg, the one that is quoted in textbooks around the world. (It +is the one that I start with when I teach quantum mechanics.) It says that +to determine the state of the cat, you must open the box and make a +measurement. The cat’s wave (which was the sum of a dead cat and a +live cat) now “collapses” into a single wave, so the cat is now known to +be alive (or dead). Thus, observation determines the existence and state +of the cat. The measurement process is thus responsible for two waves + +magically dissolving into a single wave." +"magically dissolving into a single wave. + +Einstein hated this. For centuries, scientists have battled something +called “solipsism” or “subjective idealism,” which claims that objects +cannot exist unless there is someone there to observe them. Only the +mind is real—the material world exists only as ideas in the mind. Thus, +say the solipsists (such as Bishop George Berkeley), if a tree falls in the +forest but no one is there to observe it, perhaps the tree never fell. +Einstein, who thought all this was pure nonsense, promoted an opposing +theory called “objective reality,” which says simply that the universe +exists in a unique, definite state independent of any human observation. +It is the commonsense view of most people." +"Objective reality goes back to Isaac Newton. In this scenario, the atom +and subatomic particles are like tiny steel balls, which exist at definite +points in space and time. There is no ambiguity or chance in locating the +position of these balls, whose motions can be determined by using the +laws of motion. Objective reality was spectacularly successful in +describing the motions of planets, stars, and galaxies. Using relativity, +this idea can also describe black holes and the expanding universe. But +there is one place where it fails miserably, and that is inside the atom. + +Classical physicists like Newton and Einstein thought that objective +reality finally banished solipsism from physics. Walter Lippmann, the +columnist, summed it up when he wrote, “The radical novelty of modern +science lies precisely in the rejection of the belief ... that the forces +which move the stars and atoms are contingent upon the preferences of +the human heart.”" +"But quantum mechanics allowed a new form of solipsism back into +physics. In this picture, before it is observed, a tree can exist in any +possible state (e.g., sapling, burned, sawdust, toothpicks, decayed). But + + when you look at it, the wave suddenly collapses and it looks like a tree. +The original solipsists talked about trees that either fell or didn’t. The +new quantum solipsists were introducing all possible states of a tree. + +This was too much for Einstein. He would ask guests at his house, +“Does the moon exist because a mouse looks at it?” To a quantum +physicist, in some sense the answer might be yes. + +Einstein and his colleagues would challenge Bohr by asking: How can +the quantum microworld (with cats being dead and alive +simultaneously) coexist with the commonsense world we see around us?" +"The answer was that there is a “wall” that separates our world from the +atomic world. On one side of the wall, common sense rules. On the other +side of the wall, the quantum theory rules. You can move the wall if you +want and the results are still the same. + +This interpretation, no matter how strange, has been taught for eighty +years by quantum physicists. More recently, there have been some +doubts cast on the Copenhagen interpretation. Today we have +nanotechnology, with which we can manipulate individual atoms at will. +On a scanning tunneling microscope screen, atoms appear to be fuzzy +tennis balls. (For BBC-TV, I had a chance to fly out to IBM’s Almaden +Lab in San Jose, California, and actually push individual atoms around +with a tiny probe. It is now possible to play with atoms, which were +once thought to be so small they could never be seen.)" +"As we’ve discussed, the Age of Silicon is slowly coming to an end, and +some believe that molecular transistors will replace silicon transistors. If +so, then the paradoxes of the quantum theory may lie at the very heart +of every computer of the future. The world economy may eventually rest +on these paradoxes. + +COSMIC CONSCIOUSNESS AND MULTIPLE UNIVERSES + +There are two alternate interpretations of the cat paradox, which take us +to the strangest realms in all science: the realm of God and multiple +universes. + +In 1967, the second resolution to the cat problem was formulated by +Nobel laureate Eugene Wigner, whose work was pivotal in laying the +foundation of quantum mechanics and also building the atomic bomb. +He said that only a conscious person can make an observation that +collapses the wave function. But who is to say that this person exists? +You cannot separate the observer from the observed, so maybe this" +"person is also dead and alive. In other words, there has to be a new +wave function that includes both the cat and the observer. To make sure +that the observer is alive, you need a second observer to watch the first +observer. This second observer is called “Wigner’s friend,” and is +necessary to watch the first observer so that all waves collapse. But how +do we know that the second observer is alive? The second observer has + +to be included in a still-larger wave function to make sure he is alive, +but this can be continued indefinitely. Since you need an infinite number +of “friends” to collapse the previous wave function to make sure they are +alive, you need some form of “cosmic consciousness,” or God. + +Wigner concluded: “It was not possible to formulate the laws (of +quantum theory) in a fully consistent way without reference to +consciousness.” Toward the end of his life, he even became interested in +the Vedanta philosophy of Hinduism." +"In this approach, God or some eternal consciousness watches over all +of us, collapsing our wave functions so that we can say we are alive. This +interpretation yields the same physical results as the Copenhagen +interpretation, so this theory cannot be disproven. But the implication is +that consciousness is the fundamental entity in the universe, more +fundamental than atoms. The material world may come and go, but +consciousness remains as the defining element, which means that +consciousness, in some sense, creates reality. The very existence of the +atoms we see around us is based on our ability to see and touch them." +"(At this point, it’s important to note that some people think that +because consciousness determines existence, then consciousness can +therefore control existence, perhaps by meditation. They think that we +can create reality according to our wishes. This thinking, as attractive as +it might sound, goes against quantum mechanics. In quantum physics, +consciousness makes observations and therefore determines the state of +reality, but consciousness cannot choose ahead of time which state of +reality actually exists. Quantum mechanics allows you only to determine +the chance of finding one state, but we cannot bend reality to our +wishes. For example, in gambling, it is possible to mathematically +calculate the chances of getting a royal flush. However, this does not +mean that you can somehow control the cards to get the royal flush. You +cannot pick and choose universes, just as we have no control over +whether the cat is dead or alive.) + +MULTIPLE UNIVERSES" +"MULTIPLE UNIVERSES + +The third way to resolve the paradox is the Everett, or many-worlds, + + interpretation, which was proposed in 1957 by Hugh Everett. It is the + +strangest theory of all. It says that the universe is constantly splitting +apart into a multiverse of universes. In one universe, we have a dead cat. +In another universe, we have a live cat. This approach can be +summarized as follows: wave functions never collapse, they just split. +The Everett many-worlds theory differs from the Copenhagen +interpretation only in that it drops the final assumption: the collapse of +the wave function. In some sense, it is the simplest formulation of +quantum mechanics, but also the most disturbing. + +There are profound consequences to this third approach. It means that +all possible universes might exist, even ones that are bizarre and +seemingly impossible. (However, the more bizarre the universe, the +more unlikely it is.)" +"This means people who have died in our universe are still alive in +another universe. And these dead people insist that their universe is the +correct one, and that our universe (in which they are dead) is fake. But if +these “ghosts” of dead people are still alive somewhere, then why can’t +we meet them? Why can’t we touch these parallel worlds? (As strange as +it may seem, in this picture Elvis is still alive in one of these universes.)" +"What’s more, some of these universes may be dead, without any life, +but others may look exactly like ours, except for one key difference. For +example, the collision of a single cosmic ray is a tiny quantum event. But +what happens if this cosmic ray goes through Adolf Hitler’s mother, and +the infant Hitler dies in a miscarriage? Then a tiny quantum event, the +collision of a single cosmic ray, causes the universe to split in half. In +one universe, World War II never happened, and sixty million people did +not have to die. In the other universe, we’ve had the ravages of World +War II. These two universes grow to be quite far apart, yet they are +initially separated by one tiny quantum event." +"This phenomenon was explored by science-fiction writer Philip K. Dick +in his novel The Man in the High Tower, where a parallel universe opens +up because of a single event: a bullet is fired at Franklin Roosevelt, who +is killed by an assassin. This pivotal event means that the United States +is not prepared for World War II, and the Nazis and Japanese are +victorious and eventually partition the United States in half. + +But whether the bullet fires or misfires depends, in turn, on whether a +microscopic spark is set off in the gunpowder, which itself depends on +complex molecular reactions involving the motions of electrons. So + + perhaps quantum fluctuations in the gunpowder may determine whether +the gun fires or misfires, which in turn determines whether the Allies or +the Nazis emerge victorious during World War II." +"So there is no “wall” separating the quantum world and the +macroworld. The bizarre features of the quantum theory can creep into +our “commonsense” world. These wave functions never collapse—they +keep splitting endlessly into parallel realities. The creation of alternative +universes never stops. The paradoxes of the microworld (i.e., being dead +and alive simultaneously, being in two places at the same time, +disappearing and reappearing somewhere else) now enter into our world +as well. + +But if the wave function is continually splitting apart, creating entirely +new universes in the process, then why can’t we visit them?" +"Nobel laureate Steven Weinberg compares this to listening to the radio +in your living room. There are hundreds of radio waves simultaneously +filling up your room from all over the world, but your radio dial is tuned +to only one frequency. In other words, your radio has “decohered” from +all the other stations. (Coherence is when all waves vibrate in perfect +unison, as in a laser beam. Decoherence is when these waves begin to +fall out of phase, so they no longer vibrate in unison.) These other +frequencies all exist, but your radio cannot pick them up because they +are not vibrating at the same frequency that we are anymore. They have +decoupled; that is, they have decohered from us." +"In the same way, the wave function of the dead and alive cat have +decohered as time goes on. The implications are rather staggering. In +your living room, you coexist with the waves of dinosaurs, pirates, aliens +from space, and monsters. Yet you are blissfully unaware that you are +sharing the same space as these strange denizens of quantum space, +because your atoms are no longer vibrating in unison with them. These +parallel universes do not exist in some distant never-never land. They +exist in your living room. + +Entering one of these parallel worlds is called “quantum jumping” or +“sliding” and is a favorite gimmick of science fiction. To enter a parallel +universe, we need to take a quantum jump into it. (There was even a TV +series called Sliders where people slide back and forth between parallel +universes. The series began when a young boy read a book. That book is +actually my book Hyperspace, but I take no responsibility for the physics + +behind that series.)" +"behind that series.) + +Actually, it’s not so simple to jump between universes. One problem +we sometimes give our Ph.D. students is to calculate the probability that + + you will jump through a brick wall and wind up on the other side. The +result is sobering. You would have to wait longer than the lifetime of the +universe to experience jumping or sliding through a brick wall. + +LOOKING IN THE MIRROR" +"LOOKING IN THE MIRROR + +When I look at myself in a mirror, I don’t really see myself as I truly am. +First, I see myself about a billionth of a second ago, since that is the time +that it takes a light beam to leave my face, hit a mirror, and enter my +eyes. Second, the image I see is really an average over billions and +billions of wave functions. This average certainly does resemble my +image, but it is not exact. Surrounding me are multiple images of myself +oozing in all directions. I am continually surrounded by alternate +universes, forever branching into different worlds, but the probability of +sliding between them is so tiny that Newtonian mechanics seems to be +correct." +"At this point, some people ask this question: Why don’t scientists +simply do an experiment to determine which interpretation is valid? If +we run an experiment with an electron, all three interpretations will +yield the same result. All three are therefore serious, viable +interpretations of quantum mechanics, with the same underlying +quantum theory. What is different is how we explain the results. + +Hundreds of years in the future, physicists and philosophers may still +be debating this question, with no resolution, because all three +interpretations yield the same physical results. But perhaps there is one +way in which this philosophical debate touches on the brain, and that is +the question of free will, which in turn affects the moral foundation of +human society. + +FREE W ILT. + +Our entire civilization is based on the concept of free will, which +impacts on the notions of reward, punishment, and personal" +"responsibility. But does free will really exist? Or is it a clever way of +keeping society together although it violates scientific principles? The +controversy goes to the very heart of quantum mechanics itself. + +It is safe to say that more and more neuroscientists are gradually +coming to the conclusion that free will does not exist, at least not in the +usual sense. If certain bizarre behaviors can be linked to precise defects + + in the brain, then a person is not scientifically responsible for the crimes +he might commit. He might be too dangerous to be left walking the +streets and must be locked up in an institution of some sort, but +punishing someone for having a stroke or tumor in the brain is +misguided, they say. What that person needs is medical and +psychological help. Perhaps the brain damage can be treated (e.g., by +removing a tumor), and the person can become a productive member of +society." +"For example, when I interviewed Dr. Simon Baron-Cohen, a +psychologist at Cambridge University, he told me that many (but not all) +pathological killers have a brain anomaly. Their brain scans show that +they lack empathy when seeing someone else in pain, and in fact they +might even take pleasure in watching this suffering (in these individuals, +the amygdala and the nucleus accumbens, the pleasure center, light up +when they view videos of people experiencing pain). + +The conclusion some might draw from this is that these people are not +truly responsible for their heinous acts, although they should still be +removed from society. They need help, not punishment, because of a +problem with their brain. In a sense, they may not be acting with free +will when they commit their crimes." +"An experiment done by Dr. Benjamin Libet in 1985 casts doubt on the +very existence of free will. Let’s say that you are asking subjects to watch +a clock and then to note precisely when they decide to move a finger. +Using EEG scans, one can detect exactly when the brain makes this +decision. When you compare the two times, you will find a mismatch. +The EEG scans show that the brain has actually made the decision about +three hundred milliseconds before the person becomes aware of it. + +This means that, in some sense, free will is a fake. Decisions are made +ahead of time by the brain, without the input of consciousness, and then +later the brain tries to cover this up (as it’s wont to do) by claiming that +the decision was conscious. Dr. Michael Sweeney concludes, “Libet’s + +findings suggested that the brain knows what a person will decide before +the person does.... The world must reassess not only the idea of +movements divided between voluntary and involuntary, but also the +very idea of free will.”" +"All this seems to indicate that free will, the cornerstone of society, is a +fiction, an illusion created by our left brain. So are we masters of our +fate, or just pawns in a swindle perpetuated by the brain? + +There are several ways to approach this sticky question. Free will goes +against a philosophy called determinism, which simply says that all + + future events are determined by physical laws. According to Newton +himself, the universe was some sort of clock, ticking away since the +beginning of time, obeying the laws of motion. Hence all events are +predictable. + +The question is: Are we part of this clock? Are all our actions also +determined? These questions have philosophical and theological +implications. For example, most religions adhere to some form of +determinism and predestination. Since God is omnipotent, omniscient, +and omnipresent, He knows the future, and hence the future is +determined ahead of time. He knows even before you are born whether +you will go to Heaven or Hell." +"The Catholic Church split in half on this precise question during the +Protestant revolution. According to Catholic doctrine at that time, one +could change one’s ultimate fate with an indulgence, usually by making +generous financial donations to the Church. In other words, determinism +could be altered by the size of your wallet. Martin Luther specifically +singled out the corruption of the Church over indulgences when he +tacked his 95 Theses on the door of a church in 1517, triggering the +Protestant Reformation. This was one of the key reasons why the Church +split down the middle, causing casualties in the millions and laying +waste to entire regions of Europe." +"But after 1925, uncertainty was introduced into physics via quantum +mechanics. Suddenly everything became uncertain; all you could +calculate was probabilities. In this sense, perhaps free will does exist, +and it’s a manifestation of quantum mechanics. So some claim that the +quantum theory reestablishes the concept of free will. The determinists +have fought back, however, claiming that quantum effects are extremely +small (at the level of atoms), too small to account for the free will of + +large human beings. + +The situation today is actually rather muddled. Perhaps the question +“Does free will exist?” is like the question “What is life?” The discovery +of DNA has rendered that question about life obsolete. We now realize +that the question has many layers and complexities. Perhaps the same +applies to free will, and there are many types." +"If so, the very definition of “free will” becomes ambiguous. For +example, one way to define free will is to ask whether behavior can be +predicted. If free will exists, then behavior cannot be determined ahead +of time. Let’s say you watch a movie, for example. The plot is completely +determined, with no free will whatsoever. So the movie is completely +predictable. But our world cannot be like a movie, for two reasons. The +first is the quantum theory, as we have seen. The movie represents only + + one possible timeline. The second reason is chaos theory. Although +classical physics says that all of the motions of atoms are completely +determined and predictable, in practice it is impossible to predict their +motions because there are so many atoms involved. The slightest +disturbance of a single atom can have a ripple effect, which can cascade +down to create enormous disturbances." +"Think of the weather. In principle, if you knew the behavior of every +atom in the air, you could predict the weather a century from now if you +had a big enough computer. But in practice, this is impossible. After just +a few hours, the weather becomes so turbulent and complex that any +computer simulation is rendered useless. + +This creates what is called the “butterfly effect,” which means that +even the beat of butterfly wings can cause tiny ripples in the +atmosphere, which grow and in turn can escalate into a thunderstorm. +So if even the flapping of butterfly wings can create thunderstorms, the +hope of accurately predicting the weather is far-fetched. + +Let’s go back to the thought experiment described to me by Stephen +Jay Gould. He asked me to imagine Earth 4.5 billion years ago, when it +was born. Now imagine you could somehow create an identical copy of +Earth, and let it evolve. Would we still be here on this different Earth 4.5 +billion years later?" +"One could easily imagine, due to quantum effects or the chaotic nature +of the weather and oceans, that humanity would never evolve into +precisely the same creatures on this version of Earth. So ultimately, it + +seems a combination of uncertainty and chaos makes a perfectly +deterministic world impossible. + +THE QUANTUM BRAIN + +This debate also affects the reverse engineering of the brain. If you can +successfully reverse engineer a brain made of transistors, this success +implies that the brain is deterministic and predictable. Ask it any +question and it repeats the exact same answer. Computers are +deterministic in this way, since they always give the same answer for +any question. + +So it seems we have a problem. On one hand, quantum mechanics and +chaos theory claim that the universe is not predictable, and therefore, +free will seems to exist. But a reverse-engineered brain, made of +transistors, would by definition be predictable. Since the reverse-" +"engineered brain is theoretically identical to a living brain, then the +human brain is also deterministic and there is no free will. Clearly, this +contradicts the first statement." +"A minority of scientists claim that you cannot authentically reverse +engineer the brain, or ever create a true thinking machine, because of +the quantum theory. The brain, they argue, is a quantum device, not just +a collection of transistors. Hence this project is doomed to fail. In this +camp is Oxford physicist Dr. Roger Penrose, an authority on Einstein’s +theory of relativity, who claims that it is quantum processes that may +account for the consciousness of the human brain. Penrose starts by +saying that mathematician Kurt Godel has proven that arithmetic is +incomplete; that is, that there are true statements in arithmetic that +cannot be proven using the axioms of arithmetic. Similarly, not only is +mathematics incomplete, but so is physics. He concludes by stating that +the brain is basically a quantum mechanical device and there are +problems that no machine can solve because of Godel’s incompleteness +theorem. Humans, however, can make sense of these conundrums using +intuition." +"Similarly, the reverse-engineered brain, no matter how complex, is +still a collection of transistors and wires. In such a deterministic system, +you can accurately predict its future behavior because the laws of + +motion are well known. In a quantum system, however, the system is +inherently unpredictable. All you can calculate are the chances that +something will occur, because of the uncertainty principle. + +If it turns out that the reverse-engineered brain cannot reproduce +human behavior, then scientists may be forced to admit that there are +unpredictable forces at work (i.e., quantum effects inside the brain). Dr. +Penrose argues that inside the neuron there are tiny structures, called +microtubules, where quantum processes dominate." +"At present, there is no consensus on this problem. Judging from the +reaction to Penrose’s idea when it was first proposed, it would be safe to +say that most of the scientific community is skeptical of his approach. +Science, however, is never conducted as a popularity contest, but instead +advances through testable, reproducible, and falsifiable theories. + +For my own part, I believe transistors cannot truly model all the +behaviors of neurons, which carry out both analog and digital +calculations. We know that neurons are messy. They can leak, misfire, +age, die, and are sensitive to the environment. To me, this suggests that +a collection of transistors can only approximately model the behavior of +neurons. For example, we saw earlier, in discussing the physics of the +brain, that if the axon of the neuron becomes thinner, then it begins to" +"leak and also does not carry out chemical reactions that well. Some of +this leakage and these misfires will be due to quantum effects. As you try +to imagine neurons that are thinner, denser, and faster, quantum effects +become more obvious. This means that even for normal neurons there +are problems of leakage and instabilities, and these problems exist both +classically and quantum mechanically. + +In conclusion, a reverse-engineered robot will give a good but not +perfect approximation of the human brain. Unlike Penrose, I think it is +possible to create a deterministic robot out of transistors that gives the +appearance of consciousness, but without any free will. It will pass the +Turing test. But I think there will be differences between such a robot +and humans due to these tiny quantum effects." +"Ultimately, I think free will probably does exist, but it is not the free +will envisioned by rugged individualists who claim they are complete +masters of their fate. The brain is influenced by thousands of +unconscious factors that predispose us to make certain choices ahead of +time, even if we think we made them ourselves. This does not + +necessarily mean that we are actors in a film that can be rewound +anytime. The end of the movie hasn’t been written yet, so strict +determinism is destroyed by a subtle combination of quantum effects +and chaos theory. In the end, we are still masters of our destiny. + +NOTES + +INTRODUCTION" +"NOTES + +INTRODUCTION + +1 You may have to travel: To see this, define “complex” in terms of the +total amount of information that can be stored. The closest rival to the +brain might be the information contained within our DNA. There are +three billion base pairs in our DNA, each one containing one of four +nucleic acids, labeled A,T,C,G. Therefore the total amount of +information we can store in our DNA is four raised to the three- +billionth power. But the brain can store much more information +among its one hundred billion neurons, which can either fire or not +fire. Hence, there are two raised to the one-hundred-billionth power +possible initial states of the human brain. But while DNA is static, the +states of the brain change every few milliseconds. A simple thought +may contain one hundred generations of neural firings. Hence, there +are two raised to one hundred billion, all raised to the hundredth +power, possible thoughts contained in one hundred generations. But" +"our brains are continually firing, day and night, ceaselessly +computing. Therefore the total number of thoughts possible within N +generations is two raised to the one-hundred-billionth power, all +raised to the Nth power, which is truly astronomical. Therefore the +amount of information that we can store in our brains far exceeds the +information stored within our DNA by a wide margin. In fact, it is the +largest amount of information that we can store in our solar system, +and even possibly in our sector of the Milky Way galaxy. + +2 “The most valuable insights”: Boleyn-Fitzgerald, p. 89. + +3 “All of these questions that philosophers”: Boleyn-Fitzgerald, p. +137. + +CHAPTER 1: UNLOCKING THE MIND + +1 He was semiconscious for weeks: See Sweeney, pp. 207-8. + +2 Dr. John Harlow, the doctor who treated: Carter, p. 24. + +3 In the year A.D. 43, records show: Horstman, p. 87. + +4 “It was like ... standing in the doorway”: Carter, p. 28. + +5 The Transparent Brain: New York Times, April 10, 2013, p. 1." +"5 The Transparent Brain: New York Times, April 10, 2013, p. 1. + +6 “Emotions are not feelings at all”: Carter, p. 83. + +7 the mind is more like a “society of minds”: Interview with Dr. +Minsky for the BBC-TV series Visions of the Future, February 2007. +Also, interview for Science Fantastic national radio broadcast, +November 2009. + +8 consciousness was like a storm raging: Interview with Dr. Pinker in +September 2003 for Exploration national radio broadcast. + +9 “the intuitive feeling we have”: Pinker, “The Riddle of Knowing +You’re Here,” in Your Brain: A User’s Guide (New York: Time Inc. +Specials, 2011). + +10 Consciousness turns out to consist of: Boleyn-Fitzgerald, p. 111. + +11 “indeed a conscious system in its own right”: Carter, p. 52. + +12 I asked him how experiments: Interview with Dr. Michael +Gazzaniga in September 2012 for Science Fantastic national radio +broadcast. + + 13 “The possible implications of this”: Carter, p. 53. + +14 “If that person dies, what happens?”: Boleyn-Fitzgerald, p. 119." +"14 “If that person dies, what happens?”: Boleyn-Fitzgerald, p. 119. + +15 a young king who inherits: Interview with Dr. David Eagleman in +May 2012 for Science Fantastic national radio broadcast. + +16 “people named Denise or Dennis”: Eagleman, p. 63. + +17 “at least 15 % of human females”: Eagleman, p. 43. + +CHAPTER 2: CONSCIOUSNESS—A PHYSICIST’S VIEWPOINT + +1 “We cannot see ultraviolet light”: Pinker, How the Mind Works, pp. +561-65. + +2 “Everybody knows what consciousness is”: Biological Bulletin 215, +no. 3 (December 2008): 216." +"2 “Everybody knows what consciousness is”: Biological Bulletin 215, +no. 3 (December 2008): 216. + +3 We will do so in the notes: Level II consciousness can be counted by +listing the total number of distinct feedback loops when an animal +interacts with members of its species. As a rough guess, Level II +consciousness can be approximated by multiplying the number of +others in an animal’s pack or tribe, multiplied by the total number of +distinct emotions or gestures it uses to communicate with others. +There are caveats to this ranking, however, since this is just a first +guess. + +For example, animals like the wildcat are social, but they are also +solitary hunters, so it appears as if the number of animals in its pack is +one. But that is true only when it is hunting. When it is time to +reproduce, wildcats engage in complex mating rituals, so its Level II +consciousness must take this into account." +"Furthermore, when female wildcats give birth to litters of kittens, +which have to be nursed and fed, the number of social interactions +increases as a consequence. So even for solitary hunters, the number +of members of its species that it interacts with is not one, and the total +number of distinct feedback loops can be quite large. + +Also, if the number of wolves in the pack decreases, then it appears +as if its Level II number decreases correspondingly. To account for +this, we have to introduce the concept of an average Level II number +that is common for the entire species, as well as a specific Level II +consciousness for an individual animal. + + The average Level II number for a given species does not change if +the pack gets smaller, because it is common for the entire species, but +the individual Level II number (because it measures individual mental +activity and consciousness) does change." +"When applied to humans, the average Level II number must take +into account the Dunbar number, which is 150, and represents roughly + +the number of people in our social grouping that we can keep track of. +So the Level II number for humans as a species would be the total +number of distinct emotions and gestures we use to communicate, +multiplied by the Dunbar number of 150. (Individuals can have +different levels of Level II consciousness, since their circle of friends +and the ways they interact with them can vary considerably.) + +We should also note that certain Level I organisms (like insects and +reptiles) can exhibit social behaviors. Ants, when they bump into one +another, exchange information via chemical scents, and bees dance to +communicate the location of flower beds. Reptiles even have a +primitive limbic system. But in the main, they do not exhibit +emotions. + +4 “The difference between man”: Gazzaniga, p. 27. + +5 “The greatest achievement of the human brain”: Gilbert, p. 5." +"5 “The greatest achievement of the human brain”: Gilbert, p. 5. + +6 “area 10 (the internal granular layer IV)”: Gazzaniga, p. 20. + +7 The male gets confused, because it wants: Eagleman, p. 144. + +8 “I predict that mirror neurons”: Brockman, p. xiii. + +9 Biologist Carl Zimmer writes: Bloom, p. 51. + +10 “Most of the time we daydream”: Bloom, p. 51. + +Ill asked one person who may: Interview with Dr. Michael Gazzaniga +in September 2012 for Science Fantastic national radio broadcast. + +12 “It is the left hemisphere”: Gazzaniga, p. 85. + +CHAPTER 3: TELEPATHY—A PENNY FOR YOUR THOUGHTS + +1 Indeed, in a recent “Next 5 in 5”: http://www.ibm.com/5in5. + +2 I had the pleasure of touring: Interview with Dr. Gallant on July 11, + + 2012, at the University of California, Berkeley. Also, interview with +Dr. Gallant on Science Fantastic for national radio, July 2012. + +3 “This is a major leap forward”: Berkeleyan Newsletter, September +22, 2011, http://newscenter.berkeley.edu/2011/09/22/brain-movies." +"4 “If you take 200 voxels”: Brockman, p. 236. + +5 Dr. Brian Pasley and his colleagues: Visit to Dr. Pasley’s laboratory +on July 11, 2012, at the University of California, Berkeley. + +6 Similar results were obtained: The Brain Institute, University of +Utah, Salt Lake City, http://brain.utah.edu. + +7 This could have applications for artists: http://io9/543338/a- +device-that-lets-io9.com/543338/a-device-that-lets-ou-type-with-your- +mind. + +8 According to their officials: http://news.discovery.com/tech/type- +with-your-mind-110309.html. + +9 being explored by Dr. David Poeppel: Discover Magazine Presents the +Brain, Spring 2012, p. 43. + +10 In 1993 in Germany: Scientific American, November 2008, p. 68. + +11 The only justification for its existence: Garreau, pp. 23-24. + +12 I once had lunch with: Symposium on the future of science +sponsored by the Science Fiction Channel at the Chabot Pace and +Science Center, Oakland, California, in May 2004." +"13 On another occasion: Conference in Anaheim, California, April +2009. + +14 He says, “Imagine if soldiers”: Garreau, p. 22. + +15 “What he is doing is spending”: Ibid., p. 19. + +16 When I asked Dr. Nishimoto: Visit to Dr. Gallant’s laboratory at the +University of California, Berkeley, on July 11, 2012. + +17 “There are ethical concerns”: http://www.nbcnews.com/ +id/47447302/ns/health-health_care/t/paralyzed-woman-gets-robotic- +arm.html. + +CHAPTER 4: TELEKINESIS: MIND CONTROLLING MATTER + + 1 “I would love to have”: New York Times, May 17, 2012, p. A17 and +http://www.msnbc.mns.eom/id/47447302/ns/health-health_care/t/ +parallyzed-woman-gets-robotic-arm.html. + +2 “We have taken a tiny sensor”: Interview with Dr. John Donoghue in +November 2009 for Science Fantastic national radio broadcast. + +3 In the United States alone, more than two hundred thousand: + +Centers for Disease Control and Prevention, Washington, D.C. http:// +www. ede. go v/traumatiebraininj ury/scifacts. html ." +"4 When the monkey wanted to move: + +http://physio.northwestern.edu/faculty/miller.htm; http://www. + +northwestern.edu/newscenter/stories/2012/04/miller-paralyzed- + +technology.html. + +5 “We are eavesdropping on the natural”: http://www.northwestern. +edu/newscenter/stories/2012/04/miller-paralyzed-technology.html. + +6 More than 1,300 service members: http://www.darpa.mil/Our_ +Work/DSO/Programs/Revolutionizing_Prosthetics.aspx. CBS 60 +Minutes, broadcast on December 30, 2012. + +7 “They thought we were crazy”: Ibid. + +8 she appeared on 60 Minutes: Ibid. + +9 “There’s going to be a whole ecosystem”: Wall Street Journal, May +29, 2012. + +10 But perhaps the most novel applications: Interview with Dr. +Nicolelis in April 2011 for Science Fantastic national radio broadcast." +"11 Smart Hands and Mind Melds: New York Times, March 13, 2013, +http://nytimes.com/2013/03/01/science/new-research-suggests-two- +rat-brains-can-be-linked. See also Huffington Post, February 28, 2013, +http://www.huffingtonpost.com/2013/02/28/mind-melds-brain- +communication_n_2781609.html. + +12 In 2013, the next important step: USA Today, August 8, 2013, p. +ID. + + 13 About ten years ago: Interview with Dr. Nicolelis in April 2011. + +14 “so there’s nothing sticking out”: For a full discussion of the +exoskeleton, see Nicolelis, pp. 303-7. + +15 The Honda Corporation has: http://www.asimo.honda.com. Also, +interview with the creators of ASIMO in April 2007 for the BBC-TV +series Visions of the Future. + +16 Eventually, you get the hang: http://discovermagazine.com/2007/ +may/re vie w-test- driving- the -future . + +17 Then, by thinking, the patient: Discover, December 9, 2011, http:// +discovermagazine.com/2011/dec/09-mind-over-motor-controlling- +robots-with-your-thoughts." +"18 “We will likely be able to operate”: Nicolelis, p. 315. + +19 I saw a demonstration of this: Interview with the scientists at +Carnegie Mellon in August 2010 for the Discovery/Science Channel TV +series Sci Fi Science. + +CHAPTER 5: MEMORIES AND THOUGHTS MADE TO ORDER + +1 “It has all come together”: Wade, p. 89. + +2 So far, scientists have identified: Ibid., p. 91. + +3 For instance, Dr. Antonio Damasio: Damasio, pp. 130-53. + +4 One fragment of memory might: Wade, p. 232. + +5 “If you can’t do it”: http://www.newscientist.com/article/dn3488. + +6 “Turn the switch on”: http://www.eurekalert.org/pub_releases/2011- +06/uosc-rmr06211 .php. + +7 “Using implantables to enhance competency”: http://hplus +magazine.com/2009/03/18/artificial-hipppocampus. + +8 Not surprisingly, with so much at stake: http://articles. +washingtonpost.com/2013-07-12/national/40863765_l_brain-cells- +mice-new-memories." +"9 If encoding the memory: This brings up the question of whether +carrier pigeons, migratory birds, whales, etc., have a long-term +memory, given that they can migrate over hundreds to thousands of + + miles in search of feeding and breeding grounds. Science knows little +about this question. But it is believed that their long-term memory is +based on locating certain landmarks along the way, rather than +recalling elaborate memories of past events. In other words, they do +not use memory of past events to help them simulate the future. Their +long-term memory consists of just a series of markers. Apparently, +only in humans are long-term memories used to help simulate the +future. + +10 “The purpose of memory is”: Michael Lemonick, “Your Brain: A +User’s Guide,” Time, December 2011, p. 78. + +11 “You might look at it”: http://sciencedaily.com/videos/2007/0210- +brain_scans_of_the_future.htm. + +12 their study proves a “tentative answer”: http://www.sciencedaily. +com/videos/2007/0710." +"12 their study proves a “tentative answer”: http://www.sciencedaily. +com/videos/2007/0710. + +13 “The whole idea is that the device”: New York Times, September + +12, 2012, p. A18. + +14 “It will likely take us”: http://www.tgdaily.com/general-sciences- +features/58736-artificial-cerebellum-restores-rats. + +15 There are 5.3 million Americans: Alzheimer’s Foundation of +America, http://www.alzfdn.org. + +16 “This adds to the notion”: ScienceDaily.com, October 2009, http:// +www.sciencedaily.com/releases/2009/10/091019122647.htm. + +17 “We can never turn it into”: Ibid. + +18 “This implies these flies have”: Wade, p. 113. + +19 This effect is not just restricted: Ibid. + +20 “We can now give you”: Ibid., p. 114. + +21 Basically, the more CREB proteins: Bloom, p. 244. + +22 “Propranolol sits on that nerve cell”: SATI e-News, June 28, 2007, +http://www.mysati.com/enews/June2007/ptsd.htm. + +23 Its report concluded: Boleyn-Fitzgerald, p. 104. + +24 “Our breakups, our relationships”: Ibid." +"23 Its report concluded: Boleyn-Fitzgerald, p. 104. + +24 “Our breakups, our relationships”: Ibid. + + 25 “should we deprive them of morphine”: Ibid., p. 105. + +26 “If further work confirms this view”: Ibid., p. 106. + +27 “Each of these perennial records”: Nicolelis, p. 318. + +28 “Forgetting is the most beneficial process”: New Scientist, March +12, 2003, http://www.newscientists.com/article/dn3488. + +CHAPTER 6: EINSTEIN’S BRAIN AND ENHANCING INTELLIGENCE + +1 “got caught up in the moment”: + +http://abcnews.go.com/blogs/headlines/2012/03/einsteins-brain- + +arrives-in-london-after-odd-journey. + +2 “I have always maintained that”: Gould, p. 109. + +3 “The human brain remains ‘plastic’ ”: www.sciencedaily.com/ +releases/2011/12/111208257120.htm. + +4 “The emerging picture from such studies”: Gladwell, p. 40. + +5 Five years later, Terman started: See C. K. Holahan and R.R. Sears, +The Gifted Group in Later Maturity (Stanford, CA: Stanford University +Press, 1995)." +"6 “Your grades in school”: Boleyn-Fitzgerald, p. 48. + +7 “Tests don’t measure motivation”: Sweeney, p. 26. + +8 The pilots who scored highest: Bloom, p. 12. + +9 “The left hemisphere is responsible”: Ibid., p. 15. + +10 Dr. Darold Treffert, a Wisconsin physician: http://www.darold +treffert.com. + +11 It took him just forty-five seconds: Tammet, p. 4. + +12 I had the pleasure of interviewing: Interview with Mr. Daniel +Tammet in October 2007 for Science Fantastic national radio broadcast. + +13 “Our study confirms”: Science Daily, March 2012, http://www. +sciencedaily.com/releases/2012/03/120322100313.htm. + + 14 Kim Peek’s brain: AP wire story, November 8, 2004, http://www. +Space.com. + +15 In 1998 , Dr. Bruce Miller: Neurology 51 (October 1998): pp. 978- +82. See also http://www.wisconsinmedicalsociety.org/savant_ +syndrome/savant-articles/acquired_savant. + +16 In addition to the savants: Sweeney, p. 252." +"16 In addition to the savants: Sweeney, p. 252. + +17 This idea has actually been tried: Center of the Mind, Sydney, +Australia, http://www.centerofthemind.com. + +18 In another experiment, Dr. R. L. Young: R. L. Young, M. C. +Ridding, and T. L. Morrell, “Switching Skills on by Turning Off Part of +the Brain,” Neurocase 10 (2004): 215, 222. + +19 “When applied to the prefrontal lobes”: Sweeney, p. 311. + +20 Until recently, it was thought: Science Daily, May 2012, http:// +www.sciencedaily.com/releases/2012/05/120509180113.htm. + +21 “Savants have a high capacity”: Ibid. + +22 In 2007 , a breakthrough occurred: Sweeney, p. 294. + +23 “Stem cell research and regenerative medicine”: Sweeney, p. 295. + +24 Scientists have focused on a few genes: Katherine S. Pollard, +“What Makes Us Different,” Scientific American Special Collectors Edition +(Winter 2013): 31-35. + +25 “I jumped at the opportunity”: Ibid. + +26 “With my mentor David Haussler”: Ibid." +"25 “I jumped at the opportunity”: Ibid. + +26 “With my mentor David Haussler”: Ibid. + +27 One such gene was discovered: TG Daily, November 15, 2012. +http://www.tgdaily.com/general-sciences-features/67503-new-found- +gene-separates-man-from-apes. + +28 Many theories have been proposed: See, for example, Gazzaniga, +Human: The Science Behind What Makes Us Unique. + +29 “For the first few hundred million years”: Gilbert, p. 15. + +30 “Cortical gray matter neurons are working”: Douglas Fox, “The +Limits of Intelligence,” Scientific American, July 2011, p. 43. + +31 “You might call it the mother”: Ibid., p. 42. + + CHAPTER 7: IN YOUR DREAMS + +1 He followed this up with one thousand: C. Hall and R. Van de + +Castle, The Content Analysis of Dreams (New York: Appleton-Century- +Crofts, 1966). + +2 When I interviewed him, he told me: Interview with Dr. Allan +Hobson in July 2012 for Science Fantastic national radio broadcast. + +3 Studies have shown that it is possible: Wade, p. 229." +"3 Studies have shown that it is possible: Wade, p. 229. + +4 ATR chief scientist Yukiyasu Kamitani: New Scientist, December 12, + +2008, http://www.newscientist.com/article/dnl 6267-mindreading- + +software-could-record-your-dreams.html#.UvE9P0Qi07s. + +5 When I visited the laboratory: Visit to Dr. Gallant’s laboratory on +July 11, 2012. + +6 “Our dreams are therefore not”: Science Daily, October 28, 2011, +http://www.sciencedaily.com/releases/2011/10/111028113626.htm. + +7 Already, prototypes of Internet contact lenses: See the work of Dr. +Babak Parviz, http://www.wearable-technologies.com/262. + +CHAPTER 8: CAN THE MIND BE CONTROLLED? + +1 A raging bull is released: Miguel Nicolelis, Beyond Boundaries (New +York: Henry Holt, 2011), pp. 228-32. + +2 The cold war hysteria eventually reached: “Project MKUltra, the" +"2 The cold war hysteria eventually reached: “Project MKUltra, the + +CIA’s Program of Research into Behavioral Modification. Joint +Hearings Before the Select Committee on Human Resources, U.S. +Senate, 95th Congress, First Session,” Government Printing Office, +August 8, 1977, Washington, D.C., http://www.nytimes.com/ + +packages/pdf/national/13inmate_ProjectMKULTRA.pdf; “CIA Says It +Found More Secret Papers on Behavior Control,” New York Times, +September 3, 1977; “Government Mind Control Records of MKUltra +and Bluebird/Artichoke,” http://wanttoknow.info/mindcontrol.shtml; +“The Select Committee to Study Governmental Operations with" +"Respect to Intelligence Activities, Foreign and Military Intelligence.” +The Church Committee Report No. 94-755, 94th Congress, 2nd +Session, p. 392, Government Printing Office, Washington, D.C., 1976; +“Project MKUltra, the CIA’s Program of Research in Behavior +Modification,” http://scribd.com/doc/75512716/Project-MKUltra- +The-CIA-s-Program-of-Research-in-Behavior-Modification. + +3 “great potential for development”: Rose, p. 292. + +4 “neuro-scientific impossibility”: Ibid., p. 293. + +5 “It is probably significant that”: “Hypnosis in Intelligence,” Black +Vault Freedom of Information Act Archive, 2008, http://documents. +theblackvault.com/documents/mindcontrol/hypnosisinintelligence. +pdf. + +6 To see how widespread this problem: Boleyn-Fitzgerald, p. 57. + +7 Drugs like LSD: Sweeney, p. 200. + +8 “This is the first time we’ve shown”: Boleyn-Fitzgerald, p. 58. + +9 “If you want to turn off”: http://www.nytimes.com/2011/05/17/ +science/17optics.html." +"9 “If you want to turn off”: http://www.nytimes.com/2011/05/17/ +science/17optics.html. + +10 “By feeding information from sensors”: New York Times, March 17, +2011, http://nytimes.com/2011/05/17/science/17optics.html. + +CHAPTER 9: ALTERED STATES OF CONSCIOUSNESS + +1 “Some fraction of history’s prophets”: Eagleman, p. 207. + +2 “Sometimes it’s a personal God”: Boleyn-Fitzgerald, p. 122. + +3 “ ‘Finally, I see what it is’ ”: Ramachandran, p. 280. + +4 “During the three minute bursts”: David Biello, Scientific American, +p. 41, www.sciammind.com. + +5 To test these ideas: Ibid., p. 42. + +6 “Although atheists might argue”: Ibid., p. 45. + +7 “If you are an atheist”: Ibid., p. 44. + +8 One theory holds that Parkinson’s: Sweeney, p. 166. + + 9 “Neurons wired for the sensation”: Ibid., p. 90. + +10 “The brain’s gonna do what”: Ibid., p. 165. + +11 “Brain scans have led researchers”: Ibid., p. 208. + +12 “If left unchecked, the left hemisphere”: Ramachandran, p. 267. + +13 Underactivity in this area: Carter, pp. 100-103." +"13 Underactivity in this area: Carter, pp. 100-103. + +14 Ten percent of them, in turn: Baker, pp. 46-53. + +15 “Depression 1.0 was psychotherapy”: Ibid., p. 3. + +16 One to three percent of DBS patients: Carter, p. 98. + +17 “The calcium channels findings suggest”: New York Times, + +February 26, 2013, http://www.nytimes.com/2013/03/01/ + +health/study-finds-genetic-risk-factors-shared-by-5-psychiatric- +disorders.html. + +18 “What we have identified here”: Ibid. + +CHAPTER 10: THE ARTIFICIAL MIND AND SILICON CONSCIOUSNESS + +1 “Machines will be capable”: Crevier, p. 109. + +2 “within a generation ... the problem”: Ibid. + +3 “It’s as though a group of people”: Kaku, p. 79. + +4 “I would pay a lot for a robot”: Brockman, p. 2. + +5 However, I met privately with: Interview with the creators of ASIMO +during a visit to Honda’s laboratory in Nagoya, Japan, in April 2007 +for the BBC-TV series Visions of the Future." +"6 he used to marvel at the mosquito: Interview with Dr. Rodney +Brooks in April 2002 for Exploration national radio broadcast. + +7 I have had the pleasure of visiting: Visit to MIT Media Laboratory +for the Discovery/Science Channel TV series Sci Fi Science, April 13, +2010 . + +8 “That is why Breazeal decided”: Moss, p. 168. + + 9 At Waseda University: Gazzaniga, p. 352. + +10 Their goal is to integrate: Ibid., p. 252. + +11 Meet Nao: Guardian, August 9, 2010, http://www.theguardian.com/ +technology/2010/aug/09/nao-robot-develop-display-emotions. + +12 “It’s hard to predict the future”: http://cosmomagazine.com/news/ +4177/reverse-engineering-brain. + +13 Neuroscientists like Dr. Antonio Damasio: Damasio, pp. 108-29. + +14 “In mathematics, you don’t understand”: Kurzweil, p. 248. + +15 “There could not be an objective test”: Pinker, “The Riddle of +Knowing You’re Here,” Your Brain: A User’s Guide, Winter, 2011, p. 19. + +16 At Meiji University: Gazzaniga, p. 352." +"16 At Meiji University: Gazzaniga, p. 352. + +17 “To our knowledge, this is the first”: Kurzweil.net, August 24, + +2012, http://www.kurzweilai.net/robot-learns-self-awareness. See also +Yale Daily News, September 25, 2012, + +http://yaledailynews.com/blog/2012/09/25/first-self-aware-robot- +created. + +18 When I interviewed Dr. Hans Moravec: Interview with Dr. Hans +Moravec in November 1998 for Exploration national radio broadcast. + +19 “Unleashed from the plodding pace”: Sweeney, p. 316. + +20 When I interviewed Dr. Rodney Brooks: Interview with Dr. Brooks +in April 2002 for Exploration national radio broadcast. + +21 “We don’t like to give up”: TEDTalks, http://www.ted.com/talks/ +lang/en/rodney_brooks_on_robots.html. + +22 Similarly, at the University of Southern California: http://phys. +org/news205059692.html. + +CHAPTER 11: REVERSE ENGINEERING THE BRAIN + +1 Almost simultaneously, the European Commission: http://actu. +epfl.ch/news/the-human-brain-project-wins-top-european-science." +"2 “It’s essential for us to understand”: + +http://blog.ted.eom/2009/l 0/15/supercomputing. + +3 “There’s not a single neurological disease”: Kushner, p. 19. + +4 “I think we’re far from playing God”: Ibid., p. 2. + +5 “In a hundred years, I’d like”: Sally Adee, “Reverse Engineering the +Brain,” IEEE Spectrum, http://spectrum.ieee.org/biomedical/ethics/ +reverse-engineering-the-brain. + +6 “Researchers have conjectured”: + +http://www.cnn.corn/2012/03/01/tech/innovation/brain-map- + +connectome. + +“In the seventeenth century”: + +http: //www. ted. com/talks/lang/en/sebastian_seung .html . + +8 “The Allen Human Brain Atlas provides”: http://ts-si.org/ +neuroscience/29735-allen-human-brain-atlas-updates-with- +comprehensive). + +9 According to Dr. V. S. Ramachandran: TED Talks, January 2010, +http://www.ted.com. + +CHAPTER 12: THE FUTURE: MIND BEYOND MATTER + +1 5.8 percent claimed they had an out-of-body: Nelson, p. 137. + +2 “I see myself lying in bed”: Ibid., p. 140." +"2 “I see myself lying in bed”: Ibid., p. 140. + +3 Notably, temporary loss of blood: National Geographic News, April 8, +2010, http://news.nationalgeographic.eom/news/2010/04/100408- +near-death-experiences-blood-carbon-dioxide; Nelson, p. 126 + +4 Dr. Thomas Lempert, neurologist: Nelson, p. 126. + +5 The U.S. Air Force, for example: Ibid., p. 128. + +6 We once spoke at a conference: Dubai, United Arab Emirates, +November 2012. Interviewed in February 2003 for Exploration +national radio broadcast. Interviewed in October 2012 for Science + + Fantastic national radio broadcast. + +7 By 2055, $1,000 of computing power: Bloom, p. 191. + +8 For example, Bill Gates, cofounder: Sweeney, p. 298. + +9 “People who predict a very utopian future”: Carter, p. 298. + +10 He told me that the San Diego Zoo: Interview with Dr. Robert +Lanza in September 2009 for Exploration national radio broadcast. + +11 “Should we ridicule the modern seekers”: Sebastian Seung, +TEDTalks, http://www.ted.com/talks/lang/en/sebastian_seung.html ." +"12 In 2008, BBC-TV aired: http://www.bbc.co.uk/sn/tvradio/ +programmes/horizon/broadband/tx/isolation/timeline. + +13 we will be able to reverse engineer: Interview with Dr. Moravec in +November 1998 for Exploration national radio broadcast. + +14 On the other side was Eric Drexler: See a series of letter in +Chemical and Engineering News from 2003 to 2004. + +15 “I’m not planning to die”: Garreau, p. 128. + +CHAPTER 13: THE MIND AS PURE ENERGY + +1 “Wormholes, extra dimensions”: Sir Martin Rees, Our Final Hour +(New York: Perseus Books, 2003), p. 182. + +CHAPTER 14: THE ALIEN MIND + +1 So far, more than one thousand: Kepler Web Page, http://kepler. +nasa.gov. + +2 In 2013, NASA scientists announced: Ibid. + +3 how they can distinguish false messages: Interview with Dr. +Wertheimer in June 1999 for Exploration national radio broadcast. + +4 I once asked him about the giggle factor: Interview with Dr. Seth +Shostak in May 2012 for Science Fantastic national radio broadcast. + +5 He has gone on record: Ibid." +"5 He has gone on record: Ibid. + + 6 “Remember, this is the same government”: Davies, p. 22. + +7 The Greek writers: Sagan, p. 221. + +8 But St. Thomas Aquinas: Ibid. + +9 We can be fooled: Ibid. + +10 “If the fact that brutes abstract”: Ibid., p. 113. + +11 “In the blind and deaf world”: Eagleman, p. 77. + +12 we have to expand our own horizon: Interview with Dr. Paul +Davies in April 2012 for Science Fantastic national radio broadcast. + +13 “My conclusion is a startling one”: Davies, p. 159. + +14 “Although there is only a tiny probability”: Discovery News, +December 27, 2011, http://news.discovery.com/space/seti-to-scour- +the-moon-for-alien-tech-111227.htm. + +CHAPTER 15: CONCLUDING REMARKS + +1 In an article in Wired: Wired, April 2000, http://www.wired.com/ +wired/archive/8.04/joy.html. + +2 “several separate and unequal species”: Garreau, p. 139. + +3 “This techno utopia is all about”: Ibid., p. 180. + +4 “The idea that we are messin’ ”: Ibid., p. 353. + +5 “Technologies—such as gunpowder”: Ibid., p. 182." +"5 “Technologies—such as gunpowder”: Ibid., p. 182. + +6 “The you that all your friends know”: Eagleman, p. 205. + +7 “Our reality depends on what”: Ibid., p. 208. + +8 “How it is that anything so remarkable”: Pinker, p. 132. + +9 somehow create a twin of the Earth: Interview with Dr. Stephen Jay +Gould in November 1996 for Exploration national radio broadcast. + +10 “ Homo sapiens is one small twig”: Pinker, p. 133. + +11 “nothing gives life more purpose”: Pinker, “The Riddle of Knowing +You’re Here,” Time: Your Brain: A User’s Guide (Winter 2011), p. 19. + + 12 “What a perplexing masterpiece”: Eagleman, p. 224. + +APPENDIX: QUANTUM CONSCIOUSNESS? + +1 many (but not all) pathological killers: Interview with Dr. Simon +Baron-Cohen in July 2005 for Exploration national radio broadcast. + +2 Dr. Michael Sweeney concludes, “Libet’s findings”: Sweeney, p. +150. + +SUGGESTED READING + +Baker, Sherry. “Helen Mayberg.” Discover Magazine Presents the Brain. +Waukesha, WI: Kalmbach Publishing Co., Fall 2012." +"Bloom, Floyd. Best of the Brain from Scientific American: Mind, Matter, and +Tomorrow’s Brain. New York: Dana Press, 2007. + +Boleyn-Fitzgerald, Miriam. Pictures of the Mind: What the New +Neuroscience Tells Us About Who We Are. Upper Saddle River, N.J.: +Pearson Education, 2010. + +Brockman, John, ed. The Mind: Leading Scientists Explore the Brain, +Memory, Personality, and Happiness. New York: Harper Perennial, 2011. + +Calvin, William H. A Brief History of the Mind. New York: Oxford +University Press, 2004. + +Carter, Rita. Mapping the Mind. Berkeley: University of California Press, +2010 . + +Crevier, Daniel. AT. The Tumultuous History of the Search for Artificial +Intelligence. New York: Basic Books, 1993. + +Crick, Francis. The Astonishing Hypothesis: The Science Search for the Soul. +New York: Touchstone, 1994. + +Damasio, Antonio. Self Comes to Mind: Constructing the Conscious Brain. +New York: Pantheon Books, 2010." +"Davies, Paul. The Eerie Silence: Renewing Our Search for Alien Intelligence. +New York: Houghton Mifflin Harcourt, 2010. + +Dennet, Daniel C. Breaking the Spell: Religion as a Natural Phenomenon. +New York: Viking, 2006. + + -. Conscious Explained. New York: Back Bay Books, 1991. + +DeSalle, Rob, and Ian Tattersall. The Brain: Big Bangs, Behaviors, and +Beliefs. New Haven, CT: Yale University Press, 2012. + +Eagleman, David. Incognito: The Secret Lives of the Brain. New York: + +Pantheon Books, 2011. + +Fox, Douglas. “The Limits of Intelligence,” Scientific American, July 2011. + +Garreau, Joel. Radical Evolution: The Promise and Peril of Enhancing Our +Minds , Our Bodies—and What It Means to Be Human. New York: +Random House, 2005. + +Gazzaniga, Michael S. Human: The Science Behind What Makes Us Unique. +New York: HarperCollins, 2008. + +Gilbert, Daniel. Stumbling on Happiness. New York: Alfred A. Knopf, + +2006. + +Gladwell, Malcolm. Outliers: The Story of Success. New York: Back Bay +Books, 2008." +"2006. + +Gladwell, Malcolm. Outliers: The Story of Success. New York: Back Bay +Books, 2008. + +Gould, Stephen Jay. The Mismeasure of Man. New York: W. W. Norton, +1996. + +Horstman, Judith. The Scientific American Brave New Brain. San +Francisco: John Wiley and Sons, 2010. + +Kaku, Michio. Physics of the Future. New York: Doubleday, 2009. + +Kurzweil, Ray. How to Create a Mind: The Secret of Human Thought +Revealed. New York: Viking Books, 2012. + +Kushner, David. “The Man Who Builds Brains.” Discover Magazine +Presents the Brain. Waukesha, WI: Kalmbach Publishing Co., Fall 2001. + +Moravec, Hans. Mind Children: The Future of Robot and Human +Intelligence. Cambridge, MA: Harvard University Press, 1988. + +Moss, Frank. The Sorcerers and Their Apprentices: How the Digital +Magicians of the MIT Media Lab Are Creating the Innovative Technologies +That Will Transform Our Lives. New York: Crown Business, 2011. + + Nelson, Kevin. The Spiritual Doorway in the Brain. New York: Dutton, +2011." +"Nelson, Kevin. The Spiritual Doorway in the Brain. New York: Dutton, +2011. + +Nicolelis, Miguel. Beyond Boundaries: The New Neuroscience of Connecting +Brains with Machines—and How It Will Change Our Lives. New York: +Henry Holt and Co., 2011. + +Pinker, Steven. How the Mind Works. New York: W. W. Norton, 2009. + +-. The Stuff of Thought: Language as a Window into Human + +Nature. New York: Viking, 2007. + +-. “The Riddle of Knowing You’re Here.” In Your Brain: A + +User’s Guide. New York: Time Inc. Specials, 2011. + +Piore, Adam. “The Thought Helmet: The U.S. Army Wants to Train +Soldiers to Communicate Just by Thinking.” The Brain, Discover +Magazine Special, Spring 2012. + +Purves, Dale, et al., eds. Neuroscience. Sunderland, MA: Sinauer +Associates, 2001. + +Ramachandran, V. S. The Tell-Tale Brain: A Neuroscientist’s Quest for What +Makes Us Human. New York: W. W. Norton, 2011." +"Rose, Steven. The Future of the Brain: The Promise and Perils of Tomorrow’s +Neuroscience. Oxford, UK: Oxford University Press, 2005. + +Sagan, Carl. The Dragons of Eden: Speculations on the Evolution of Human +Intelligence. New York: Ballantine Books, 1977. + +Sweeney, Michael S. Brain: The Complete Mind: How It Develops, How It +Works, and How to Keep It Sharp. Washington, D.C.: National +Geographic, 2009. + +Tammet, Daniel. Bom on a Blue Day: Inside the Extraordinary Mind of an +Autistic Savant. New York: Free Press, 2006. + +Wade, Nicholas, ed. The Science Times Book of the Brain. New York: New +York Times Books, 1998. + +ILLUSTRATION CREDITS + + 1.1 Jeffrey L. Ward + +1.2 Jeffrey L. Ward + +1.3 Jeffrey L. Ward + +1.4 Jeffrey L. Ward + +1.5 AP Photo / David Duprey + +1.5a Tom Barrick, Chris Clark / Science Source + +1.6 Jeffrey L. Ward + +2.1 Jeffrey L. Ward + +2.2 Jeffrey L. Ward + +2.3 Jeffrey L. Ward + +4.1 The Laboratory of Dr. Miguel Nicolelis, Duke University + +5.1 Jeffrey L. Ward" +"4.1 The Laboratory of Dr. Miguel Nicolelis, Duke University + +5.1 Jeffrey L. Ward + +10.1 MIT Media Lab, Personal Robots Group + +10.2 MIT Media Lab, Personal Robots Group, Mikey Siegel + +A Note About the Author + +MICHIO KAKU is a professor of theoretical physics at the City College +and City University of New York; cofounder of string field theory; the +author of several widely acclaimed science books, including Hyperspace, +Beyond Einstein, Physics of the Impossible, and Physics of the Future; and +host of numerous TV specials and a national science radio show. + +Other titles by Michio Kaku available in eBook format +Parallel Worlds • 9780385514163 +Physics of the Future • 9780385530811 +Physics of the Impossible • 9780385525442 + +Visions • 9780307794772 + +Visit mkaku.org + +For more information on Doubleday books + + Visit: www.doubleday.com +Like: facebook.com/DoubledayBooks +Follow: @doubledaypub + +ALSO BY THE AUTHOR + +Physics of the Future +Physics of the Impossible +Parallel Worlds +Hyperspace +Visions" +"Physics of the Future +Physics of the Impossible +Parallel Worlds +Hyperspace +Visions + +Einstein’s Cosmos +Beyond Einstein" +"DR. MICHIO KAMI + +PROFESSOR OF THEORETICAL PHYSICS +CITY UNIVERSITY OI : NEW YORK + +THE SCIENTIFIC QUEST TO UNDERSTAND +ENHANCE, AND EMPOWER THE MIND + +DOUBLEPAY + +NEW YORK LONDON TORONTO + +SYDNEY AUCKLAND + +Copyright © 2014 by Michio Kaku + +All rights reserved. Published in the United States by Doubleday, a division of Random House, +LLC, New York, and in Canada by Random House of Canada Limited, Toronto, Penguin Random +House companies. + +www.doubleday.com + +doubleday and the portrayal of an anchor with a dolphin are registered trademarks of Random +House, LLC. + +Illustrations by Jeffrey L. Ward +Jacket design by Michael J. Windsor + + Jacket illustration © CLIP AREA/Custom media/Shutterstock +LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA +Kaku, Michio. + +The future of the mind : the scientific quest to understand, enhance, and empower the mind / +Dr. Michio Kaku, professor of Theoretical Physics, City University of New York. — First edition, +pages cm + +Includes bibliographical references." +"Includes bibliographical references. + +1. Neuropsychology. 2. Mind and body—Research. + +3. Brain—Mathematical models. 4. Cognitive neuroscience. + +5. Brain-computer interfaces. I. Title. +qp360.k 325 2014 +612.8—dc23 + +2013017338 + +ISBN 978-0-385-53082-8 (hardcover) ISBN 978-0-385-53083-5 (eBook) + +v3.1 + +This book is dedicated to my loving wife, Shizue, + +and my daughters, Michelle and Alyson + +CONTENTS + +Cover + +Title Page + +Copyright + +Dedication + +ACKNOWLEDGMENTS + +INTRODUCTION + + BOOK I: THE MIND AND CONSCIOUSNESS + +1 UNLOCKING THE MIND + +2 CONSCIOUSNESS—A PHYSICIST’S VIEWPOINT + +BOOK II: MIND OVER MATTER + +3 TELEPATHY: A PENNY FOR YOUR THOUGHTS + +4 TELEKINESIS: MIND CONTROLLING MATTER + +5 MEMORIES AND THOUGHTS MADE TO ORDER + +6 EINSTEIN’S BRAIN AND ENHANCING OUR INTELLIGENCE + +BOOK III: ALTERED CONSCIOUSNESS + +7 IN YOUR DREAMS + +8 CAN THE MIND BE CONTROLLED? + +9 ALTERED STATES OF CONSCIOUSNESS + +10 THE ARTIFICIAL MIND AND SILICON CONSCIOUSNESS + +11 REVERSE ENGINEERING THE BRAIN" +"10 THE ARTIFICIAL MIND AND SILICON CONSCIOUSNESS + +11 REVERSE ENGINEERING THE BRAIN + +12 THE FUTURE: MIND BEYOND MATTER + +13 THE MIND AS PURE ENERGY + +14 THE ALIEN MIND + +15 CONCLUDING REMARKS + +APPENDIX: QUANTUM CONSCIOUSNESS? + +NOTES + +SUGGESTED READING +ILLUSTRATION CREDITS +A Note About the Author + +Other Books by This Author + +ACKNOWLEDGMENTS + + It has been my great pleasure to have interviewed and interacted with +the following prominent scientists, all of them leaders in their fields. I +would like to thank them for graciously giving up their time for +interviews and discussions about the future of science. They have given +me guidance and inspiration, as well as a firm foundation in their +respective fields. + +I would like to thank these pioneers and trailblazers, especially those +who have agreed to appear on my TV specials for the BBC, Discovery, +and Science TV channels, and also on my national radio shows, Science +Fantastic and Explorations." +"Peter Doherty, Nobel laureate, St. Jude Children’s Research Hospital + +Gerald Edelman, Nobel laureate, Scripps Research Institute + +Leon Lederman, Nobel laureate, Illinois Institute of Technology + +Murray Gell-Mann, Nobel laureate, Santa Fe Institute and Cal Tech + +the late Henry Kendall, Nobel laureate, MIT + +Walter Gilbert, Nobel laureate, Harvard University + +David Gross, Nobel laureate, Kavli Institute for Theoretical Physics + +Joseph Rotblat, Nobel laureate, St. Bartholomew’s Hospital + +Yoichiro Nambu, Nobel laureate, University of Chicago + +Steven Weinberg, Nobel laureate, University of Texas at Austin + +Frank Wilczek, Nobel laureate, MIT + +Amir Aczel, author of Uranium Wars + +Buzz Aldrin, NASA astronaut, second man to walk on the moon +Geoff Andersen, U.S. Air Force Academy, author of The Telescope + +Jay Barbree, author of Moon Shot + +John Barrow, physicist, Cambridge University, author of Impossibility + +Marcia Bartusiak, author of Einstein’s Unfinished Symphony" +"Marcia Bartusiak, author of Einstein’s Unfinished Symphony + + Jim Bell, Cornell University astronomer + +Jeffrey Bennet, author of Beyond UFOs + +Bob Berman, astronomer, author The Secrets of the Night Sky + +Leslie Biesecker, National Institutes of Health + +Piers Bizony, author of How to Build Your Own Starship + +Michael Blaese, National Institutes of Health + +Alex Boese, founder of Museum of Hoaxes + +Nick Bostrom, transhumanist, Oxford University + +Lt. Col. Robert Bowman, Institute for Space and Security Studies + +Cynthia Breazeal, artificial intelligence, MIT Media Lab + +Lawrence Brody, National Institutes of Health + +Rodney Brooks, director of the MIT Artificial Intelligence Laboratory +Lester Brown, Earth Policy Institute +Michael Brown, astronomer, Cal Tech +James Canton, author of The Extreme Future + +Arthur Caplan, director of the Center for Bioethics at the University of +Pennsylvania" +"Arthur Caplan, director of the Center for Bioethics at the University of +Pennsylvania + +Fritjof Capra, author of The Science of Leonardo +Sean Carroll, cosmologist, Cal Tech +Andrew Chaikin, author of A Man on the Moon +Leroy Chiao, NASA astronaut + +Eric Chivian, International Physicians for the Prevention of Nuclear +War + +Deepak Chopra, author of Super Brain + +George Church, director of Harvard’s Center for Computational +Genetics + +Thomas Cochran, physicist, Natural Resources Defense Council + +Christopher Cokinos, astronomer, author of Fallen Sky + + Francis Collins, National Institutes of Health + +Vicki Colvin, nanotechnologist, University of Texas + +Neal Comins, author of Hazards of Space Travel + +Steve Cook, NASA spokesperson + +Christine Cosgrove, author of Normal at Any Cost + +Steve Cousins, CEO of Willow Garage Personal Robots Program + +Phillip Coyle, former assistant secretary of defense for the U.S. Defense +Department + +Daniel Crevier, AI, CEO of Coreco" +"Daniel Crevier, AI, CEO of Coreco + +Ken Croswell, astronomer, author of Magnificent Universe + +Steven Cummer, computer science, Duke University + +Mark Cutkowsky, mechanical engineering, Stanford University + +Paul Davies, physicist, author of Superforce + +Daniel Dennet, philosopher, Tufts University + +the late Michael Dertouzos, computer science, MIT + +Jared Diamond, Pulitzer Prize winner, UCLA + +Marriot DiChristina, Scientific American + +Peter Dilworth, MIT AI Lab + +John Donoghue, creator of Braingate, Brown University +Ann Druyan, widow of Carl Sagan, Cosmos Studios +Freeman Dyson, Institute for Advanced Study, Princeton University +David Eagleman, neuroscientist, Baylor College of Medicine +John Ellis, CERN physicist + +Paul Erlich, environmentalist, Stanford University +Daniel Fairbanks, author of Relics of Eden + +Timothy Ferris, University of California, author of Coming of Age in the +Milky Way Galaxy + +Maria Finitzo, stem cell expert, Peabody Award winner + + Robert Finkelstein, AI expert" +"Maria Finitzo, stem cell expert, Peabody Award winner + + Robert Finkelstein, AI expert + +Christopher Flavin, World Watch Institute + +Louis Friedman, cofounder of the Planetary Society + +Jack Gallant, neuroscientist, University of California at Berkeley + +James Garwin, NASA chief scientist + +Evelyn Gates, author of Einstein’s Telescope + +Michael Gazzaniga, neurologist, University of California at Santa +Barbara + +Jack Geiger, cofounder, Physicians for Social Responsibility + +David Gelertner, computer scientist, Yale University, University of +California + +Neal Gershenfeld, MIT Media Lab + +Daniel Gilbert, psychologist, Harvard University + +Paul Gilster, author of Centauri Dreams + +Rebecca Goldberg, Environmental Defense Fund + +Don Goldsmith, astronomer, author of Runaway Universe + +David Goodstein, assistant provost of Cal Tech + +J. Richard Gott III, Princeton University, author of Time Travel in +Einstein’s Universe + +Late Stephen Jay Gould, biologist, Harvard University" +"Late Stephen Jay Gould, biologist, Harvard University + +Ambassador Thomas Graham, spy satellites and intelligence gathering + +John Grant, author of Corrupted Science + +Eric Green, National Institutes of Health + +Ronald Green, author of Babies by Design + +Brian Greene, Columbia University, author of The Elegant Universe +Alan Guth, physicist, MIT, author of The Inflationary Universe + + William Hanson, author of The Edge of Medicine + +Leonard Hayflick, University of California at San Francisco Medical +School + +Donald Hillebrand, Argonne National Labs, future of the car +Frank N. von Hippel, physicist, Princeton University + +Allan Hobson, psychiatrist, Harvard University +Jeffrey Hoffman, NASA astronaut, MIT + +Douglas Hofstadter, Pulitzer Prize winner, Indiana University, author +of Godel, Escher, Bach + +John Horgan, Stevens Institute of Technology, author of The End of +Science + +Jamie Hyneman, host of MythBusters + +Chris Impey, astronomer, author of The Living Cosmos + +Robert Irie, AI Lab, MIT" +"Chris Impey, astronomer, author of The Living Cosmos + +Robert Irie, AI Lab, MIT + +P. J. Jacobowitz, PC magazine + +Jay Jaroslav, MIT AI Lab + +Donald Johanson, anthropologist, discoverer of Lucy +George Johnson, New York Times science journalist +Tom Jones, NASA astronaut +Steve Kates, astronomer + +Jack Kessler, stem cell expert, Peabody Award winner +Robert Kirshner, astronomer, Harvard University +Kris Koenig, astronomer + +Lawrence Krauss, Arizona State University, author of Physics of Star +Trek + +Lawrence Kuhn, filmmaker and philosopher, Closer to Truth + +Ray Kurzweil, inventor, author of The Age of Spiritual Machines + +Robert Lanza, biotechnology, Advanced Cell Technologies + +Roger Launius, author of Robots in Space + + Stan Lee, creator of Marvel Comics and Spider-Man + +Michael Lemonick, senior science editor of Time + +Arthur Lerner-Lam, geologist, volcanist + +Simon LeVay, author of When Science Goes Wrong + +John Lewis, astronomer, University of Arizona + +Alan Lightman, MIT, author of Einstein’s Dreams" +"John Lewis, astronomer, University of Arizona + +Alan Lightman, MIT, author of Einstein’s Dreams + +George Linehan, author of Space One + +Seth Lloyd, MIT, author of Programming the Universe + +Werner R. Loewenstein, former director of Cell Physics Laboratory, +Columbia University + +Joseph Lykken, physicist, Fermi National Laboratory + +Pattie Maes, MIT Media Lab + +Robert Mann, author of Forensic Detective + +Michael Paul Mason, author of Head Cases: Stories of Brain Injury and +Its Aftermath + +Patrick McCray, author of Keep Watching the Skies + +Glenn McGee, author of The Perfect Baby + +James McLurkin, MIT, AI Lab + +Paul McMillan, director of Space Watch + +Fulvia Melia, astronomer, University of Arizona + +William Meller, author of Evolution Rx + +Paul Meltzer, National Institutes of Health + +Marvin Minsky, MIT, author of The Society of Minds + +Hans Moravec, author of Robot + +Late Phillip Morrison, physicist, MIT" +"Hans Moravec, author of Robot + +Late Phillip Morrison, physicist, MIT + + Richard Muller, astrophysicist, University of California at Berkeley +David Nahamoo, IBM Human Language Technology +Christina Neal, volcanist + +Miguel Nicolelis, neuroscientist, Duke University + +Shinji Nishimoto, neurologist, University of California at Berkeley + +Michael Novacek, American Museum of Natural History + +Michael Oppenheimer, environmentalist, Princeton University + +Dean Ornish, cancer and heart disease specialist + +Peter Palese, virologist, Mount Sinai School of Medicine + +Charles Pellerin, NASA official + +Sidney Perkowitz, author of Hollywood Science + +John Pike, GlobalSecurity.org + +Jena Pincott, author of Do Gentlemen Really Prefer Blondes? + +Steven Pinker, psychologist, Harvard University +Thomas Poggio, MIT, artificial intelligence +Correy Powell, editor of Discover magazine +John Powell, founder of JP Aerospace" +"Richard Preston, author of Hot Zone and Demon in the Freezer +Raman Prinja, astronomer, University College London + +David Quammen, evolutionary biologist, author of The Reluctant Mr. +Darwin + +Katherine Ramsland, forensic scientist + +Lisa Randall, Harvard University, author of Warped Passages + +Sir Martin Rees, Royal Astronomer of Great Britain, Cambridge +University, author of Before the Beginning + +Jeremy Rifkin, Foundation for Economic Trends +David Riquier, MIT Media Lab +Jane Rissler, Union of Concerned Scientists +Steven Rosenberg, National Institutes of Health + + Oliver Sacks, neurologist, Columbia University +Paul Saffo, futurist, Institute of the Future +Late Carl Sagan, Cornell University, author of Cosmos +Nick Sagan, coauthor of You Call This the Future? + +Michael H. Salamon, NASA’s Beyond Einstein program +Adam Savage, host of MythBusters + +Peter Schwartz, futurist, founder of Global Business Network + +Michael Shermer, founder of Skeptic Society and Skeptic magazine" +"Michael Shermer, founder of Skeptic Society and Skeptic magazine + +Donna Shirley, NASA Mars program + +Seth Shostak, SETI Institute + +Neil Shubin, author of Your Inner Fish + +Paul Shurch, SETI League + +Peter Singer, author of Wired for War + +Simon Singh, author of The Big Bang + +Gary Small, author of iBrain + +Paul Spudis, author of Odyssey Moon Limited + +Stephen Squyres, astronomer, Cornell University + +Paul Steinhardt, Princeton University, author of Endless Universe + +Jack Stern, stem cell surgeon + +Gregory Stock, UCLA, author of Redesigning Humans +Richard Stone, author of NEOs and Tunguska +Brian Sullivan, Hayden Planetarium +Leonard Susskind, physicist, Stanford University +Daniel Tammet, author of Bom on a Blue Day +Geoffrey Taylor, physicist, University of Melbourne +Late Ted Taylor, designer of U.S. nuclear warheads +Max Tegmark, cosmologist, MIT +Alvin Toffler, author of The Third Wave +Patrick Tucker, World Future Society" +"Chris Turney, University of Wollongong, author of Ice, Mud and Blood +Neil de Grasse Tyson, director of Hayden Planetarium +Sesh Velamoor, Foundation for the Future + + Robert Wallace, author of Spycraft + +Kevin Warwick, human cyborgs, University of Reading, UK +Fred Watson, astronomer, author of Stargazer +Late Mark Weiser, Xerox PARC +Alan Weisman, author of The World Without Us + +Daniel Wertheimer, SETI at Home, University of California at Berkeley +Mike Wessler, MIT AI Lab + +Roger Wiens, astronomer, Los Alamos National Laboratory +Author Wiggins, author of The Joy of Physics + +Anthony Wynshaw-Boris, National Institutes of Health +Carl Zimmer, biologist, author of Evolution +Robert Zimmerman, author of Leaving Earth +Robert Zubrin, founder of Mars Society" +"I would also like to thank my agent, Stuart Krichevsky, who has been +at my side all these years and has given me helpful advice about my +books. I have always benefited from his sound judgment. In addition, I +would like to thank my editors, Edward Kastenmeier and Melissa +Danaczko, who have guided my book and provided invaluable editorial +advice. And I would like to thank Dr. Michelle Kaku, my daughter and a +neurology resident at Mount Sinai Hospital in New York, for stimulating, +thoughtful, and fruitful discussions about the future of neurology. Her +careful and thorough reading of the manuscript has greatly enhanced the +presentation and content of this book. + +INTRODUCTION" +"INTRODUCTION + +The two greatest mysteries in all of nature are the mind and the +universe. With our vast technology, we have been able to photograph +galaxies billions of light-years away, manipulate the genes that control +life, and probe the inner sanctum of the atom, but the mind and the +universe still elude and tantalize us. They are the most mysterious and +fascinating frontiers known to science. + +If you want to appreciate the majesty of the universe, just turn your +gaze to the heavens at night, ablaze with billions of stars. Ever since our +ancestors first gasped at the splendor of the starry sky, we have puzzled +over these eternal questions: Where did it all come from? What does it +all mean?" +"To witness the mystery of our mind, all we have to do is stare at +ourselves in the mirror and wonder, What lurks behind our eyes? This +raises haunting questions like: Do we have a soul? What happens to us +after we die? Who am “I” anyway? And most important, this brings us to +the ultimate question: Where do we fit into this great cosmic scheme? As +the great Victorian biologist Thomas Huxley once said, “The question of +all questions for humanity, the problem which lies behind all others and +is more interesting than any of them, is that of the determination of +man’s place in Nature and his relation to the Cosmos.”" +"There are 100 billion stars in the Milky Way galaxy, roughly the same +as the number of neurons in our brain. You may have to travel twenty- +four trillion miles, to the first star outside our solar system, to find an +object as complex as what is sitting on your shoulders. The mind and the +universe pose the greatest scientific challenge of all, but they also share +a curious relationship. On one hand they are polar opposites. One is +concerned with the vastness of outer space, where we encounter strange +denizens like black holes, exploding stars, and colliding galaxies. The +other is concerned with inner space, where we find our most intimate +and private hopes and desires. The mind is no farther than our next + +thought, yet we are often clueless when asked to articulate and explain +it." +"thought, yet we are often clueless when asked to articulate and explain +it. + +But although they may be opposites in this respect, they also have a +common history and narrative. Both were shrouded in superstition and +magic since time immemorial. Astrologers and phrenologists claimed to +find the meaning of the universe in every constellation of the zodiac and +in every bump on your head. Meanwhile, mind readers and seers have +been alternately celebrated and vilified over the years." +"The universe and the mind continue to intersect in a variety of ways, +thanks in no small part to some of the eye-opening ideas we often +encounter in science fiction. Reading these books as a child, I would +daydream about being a member of the Sian, a race of telepaths created +by A. E. van Vogt. I marveled at how a mutant called the Mule could +unleash his vast telepathic powers and nearly seize control of the +Galactic Empire in Isaac Asimov’s Foundation Trilogy. And in the movie +Forbidden Planet, I wondered how an advanced civilization millions of +years beyond ours could channel its enormous telekinetic powers to +reshape reality to its whims and wishes." +"Then when I was about ten, “The Amazing Dunninger” appeared on +TV. He would dazzle his audience with his spectacular magic tricks. His +motto was “For those who believe, no explanation is necessary; for those +who do not believe, no explanation will suffice.” One day, he declared +that he would send his thoughts to millions of people throughout the + + country. He closed his eyes and began to concentrate, stating that he was +beaming the name of a president of the United States. He asked people +to write down the name that popped into their heads on a postcard and +mail it in. The next week, he announced triumphantly that thousands of +postcards had come pouring in with the name “Roosevelt,” the very +same name he was “beaming” across the United States." +"I wasn’t impressed. Back then, the legacy of Roosevelt was strong +among those who had lived through the Depression and World War II, so +this came as no surprise. (I thought to myself that it would have been +truly amazing if he had been thinking of President Millard Fillmore.) + +Still, it stoked my imagination, and I couldn’t resist experimenting +with telepathy on my own, trying to read other people’s minds by +concentrating as hard as I could. Closing my eyes and focusing intently, I +would attempt to “listen” to other people’s thoughts and telekinetically + +move objects around my room. + +I failed." +"move objects around my room. + +I failed. + +Maybe somewhere telepaths walked the Earth, but I wasn’t one of +them. In the process, I began to realize that the wondrous exploits of +telepaths were probably impossible—at least without outside assistance. +But in the years that followed, I also slowly learned another lesson: to +fathom the greatest secrets in the universe, one did not need telepathic +or superhuman abilities. One just had to have an open, determined, and +curious mind. In particular, in order to understand whether the fantastic +devices of science fiction are possible, you have to immerse yourself in +advanced physics. To understand the precise point when the possible +becomes the impossible, you have to appreciate and understand the laws +of physics." +"These two passions have fired up my imagination all these years: to +understand the fundamental laws of physics, and to see how science will +shape the future of our lives. To illustrate this and to share my +excitement in probing the ultimate laws of physics, I have written the +books Hyperspace , Beyond Einstein, and Parallel Worlds. And to express +my fascination with the future, I have written Visions, Physics of the +Impossible, and Physics of the Future. Over the course of writing and +researching these books, I was continually reminded that the human +mind is still one of the greatest and most mysterious forces in the world. + +Indeed, we’ve been at a loss to understand what it is or how it works +for most of history. The ancient Egyptians, for all their glorious +accomplishments in the arts and sciences, believed the brain to be a +useless organ and threw it away when embalming their pharaohs." +"Aristotle was convinced that the soul resided in the heart, not the brain, +whose only function was to cool down the cardiovascular system. +Others, like Descartes, thought that the soul entered the body through +the tiny pineal gland of the brain. But in the absence of any solid +evidence, none of these theories could be proven. + +This “dark age” persisted for thousands of years, and with good +reason. The brain weighs only three pounds, yet it is the most complex +object in the solar system. Although it occupies only 2 percent of the +body’s weight, the brain has a ravenous appetite, consuming fully 20 +percent of our total energy (in newborns, the brain consumes an +astonishing 65 percent of the baby’s energy), while fully 80 percent of + +our genes are coded for the brain. There are an estimated 100 billion +neurons residing inside the skull with an exponential amount of neural +connections and pathways." +"Back in 1977, when the astronomer Carl Sagan wrote his Pulitzer +Prize-winning book, The Dragons of Eden, he broadly summarized what +was known about the brain up to that time. His book was beautifully +written and tried to represent the state of the art in neuroscience, which +at that time relied heavily on three main sources. The first was +comparing our brains with those of other species. This was tedious and +difficult because it involved dissecting the brains of thousands of +animals. The second method was equally indirect: analyzing victims of +strokes and disease, who often exhibit bizarre behavior because of their +illness. Only an autopsy performed after their death could reveal which +part of the brain was malfunctioning. Third, scientists could use +electrodes to probe the brain and slowly and painfully piece together +which part of the brain influenced which behavior." +"But the basic tools of neuroscience did not provide a systematic way of +analyzing the brain. You could not simply requisition a stroke victim +with damage in the specific area you wanted to study. Since the brain is +a living, dynamic system, autopsies often did not uncover the most +interesting features, such as how the parts of the brain interact, let alone +how they produced such diverse thoughts as love, hate, jealousy, and +curiosity. + +TWIN REVOLUTIONS + +Four hundred years ago, the telescope was invented, and almost +overnight, this new, miraculous instrument peered into the heart of the +celestial bodies. It was one of the most revolutionary (and seditious) +instruments of all time. All of a sudden, with your own two eyes, you" +"could see the myths and dogma of the past evaporate like the morning +mist. Instead of being perfect examples of divine wisdom, the moon had +jagged craters, the sun had black spots, Jupiter had moons, Venus had +phases, and Saturn had rings. More was learned about the universe in +the fifteen years after the invention of the telescope than in all human +history put together. + +Like the invention of the telescope, the introduction of MRI machines +and a variety of advanced brain scans in the mid-1990s and 2000s has +transformed neuroscience. We have learned more about the brain in the +last fifteen years than in all prior human history, and the mind, once +considered out of reach, is finally assuming center stage." +"Nobel laureate Eric R. Kandel of the Max Planck Institute in Tubingen, +Germany, writes, “The most valuable insights into the human mind to +emerge during this period did not come from the disciplines traditionally +concerned with the mind—philosophy, psychology, or psycho-analysis. +Instead they came from a merger of these disciplines with the biology of +the brain....” + +Physicists have played a pivotal role in this endeavor, providing a +flood of new tools with acronyms like MRI, EEG, PET, CAT, TCM, TES, +and DBS that have dramatically changed the study of the brain. +Suddenly with these machines we could see thoughts moving within the +living, thinking brain. As neurologist V. S. Ramachandran of the +University of California, San Diego, says, “All of these questions that +philosophers have been studying for millennia, we scientists can begin to +explore by doing brain imaging and by studying patients and asking the +right questions.”" +"Looking back, some of my initial forays into the world of physics +intersected with the very technologies that are now opening up the mind +for science. In high school, for instance, I became aware of a new form +of matter, called antimatter, and decided to conduct a science project on +the topic. As it is one of the most exotic substances on Earth, I had to +appeal to the old Atomic Energy Commission just to obtain a tiny +quantity of sodium-22, a substance that naturally emits a positive +electron (anti-electron, or positron). With my small sample in hand, I +was able to build a cloud chamber and powerful magnetic field that +allowed me to photograph the trails of vapor left by antimatter particles. +I didn’t know it at the time, but sodium-22 would soon become +instrumental in a new technology, called PET (positron emission +tomography), which has since given us startling new insights into the +thinking brain." +"Yet another technology I experimented with in high school was +magnetic resonance. I attended a lecture by Felix Bloch of Stanford + + University, who shared the 1952 Nobel Prize for Physics with Edward + +Purcell for the discovery of nuclear magnetic resonance. Dr. Bloch +explained to us high school kids that if you had a powerful magnetic +field, the atoms would align vertically in that field like compass needles. +Then if you applied a radio pulse to these atoms at a precise resonant +frequency, you could make them flip over. When they eventually flipped +back, they would emit another pulse, like an echo, which would allow +you to determine the identity of these atoms. (Later, I used the principle +of magnetic resonance to build a 2.3-million-electron-volt particle +accelerator in my mom’s garage.)" +"Just a couple of years later, as a freshman at Harvard University, it +was an honor to have Dr. Purcell teach me electrodynamics. Around that +same time, I also had a summer job and got a chance to work with Dr. +Richard Ernst, who was trying to generalize the work of Bloch and +Purcell on magnetic resonance. He succeeded spectacularly and would +eventually win the Nobel Prize for Physics in 1991 for laying the +foundation for the modern MRI (magnetic resonance imaging) machine. +The MRI machine, in turn, has given us detailed photographs of the +living brain in even finer detail than PET scans. + +EMPOWERING THE MIND" +"EMPOWERING THE MIND + +Eventually I became a professor of theoretical physics, but my +fascination with the mind remained. It is thrilling to see that, just within +the last decade, advances in physics have made possible some of the +feats of mentalism that excited me when I was a child. Using MRI scans, +scientists can now read thoughts circulating in our brains. Scientists can +also insert a chip into the brain of a patient who is totally paralyzed and +connect it to a computer, so that through thought alone that patient can +surf the web, read and write e-mails, play video games, control their +wheelchair, operate household appliances, and manipulate mechanical +arms. In fact, such patients can do anything a normal person can do via +a computer." +"Scientists are now going even further, by connecting the brain directly +to an exoskeleton that these patients can wear around their paralyzed +limbs. Quadriplegics may one day lead near-normal lives. Such +exoskeletons may also give us superpowers enabling us to handle deadly + +emergencies. One day, our astronauts may even explore the planets by +mentally controlling mechanical surrogates from the comfort of their + + living rooms." +"living rooms. + +As in the movie The Matrix, we might one day be able to download +memories and skills using computers. In animal studies, scientists have +already been able to insert memories into the brain. Perhaps it’s only a +matter of time before we, too, can insert artificial memories into our +brains to learn new subjects, vacation in new places, and master new +hobbies. And if technical skills can be downloaded into the minds of +workers and scientists, this may even affect the world economy. We +might even be able to share these memories as well. One day, scientists +might construct an “Internet of the mind,” or a brain-net, where +thoughts and emotions are sent electronically around the world. Even +dreams will be videotaped and then “brain-mailed” across the Internet." +"Technology may also give us the power to enhance our intelligence. +Progress has been made in understanding the extraordinary powers of +“savants” whose mental, artistic, and mathematical abilities are truly +astonishing. Furthermore, the genes that separate us from the apes are +now being sequenced, giving us an unparalleled glimpse into the +evolutionary origins of the brain. Genes have already been isolated in +animals that can increase their memory and mental performance." +"The excitement and promise generated by these eye-opening advances +are so enormous that they have also caught the attention of the +politicians. In fact, brain science has suddenly become the source of a +transatlantic rivalry between the greatest economic powers on the +planet. In January 2013, both President Barack Obama and the European +Union announced what could eventually become multibillion-dollar +funding for two independent projects that would reverse engineer the +brain. Deciphering the intricate neural circuitry of the brain, once +considered hopelessly beyond the scope of modern science, is now the +focus of two crash projects that, like the Human Genome Project, will +change the scientific and medical landscape. Not only will this give us +unparalleled insight into the mind, it will also generate new industries, +spur economic activity, and open up new vistas for neuroscience." +"Once the neural pathways of the brain are finally decoded, one can +envision understanding the precise origins of mental illness, perhaps +leading to a cure for this ancient affliction. This decoding also makes it + +possible to create a copy of the brain, which raises philosophical and +ethical questions. Who are we, if our consciousness can be uploaded into +a computer? We can also toy with the concept of immortality. Our +bodies may eventually decay and die, but can our consciousness live +forever? + +And beyond that, perhaps one day in the distant future the mind will + + be freed of its bodily constraints and roam among the stars, as several +scientists have speculated. Centuries from now, one can imagine placing +our entire neural blueprint on laser beams, which will then be sent into +deep space, perhaps the most convenient way for our consciousness to +explore the stars." +"A brilliant new scientific landscape that will reshape human destiny is +now truly opening up. We are now entering a new golden age of +neuroscience. + +In making these predictions, I have had the invaluable assistance of +scientists who graciously allowed me to interview them, broadcast their +ideas on national radio, and even take a TV crew into their laboratories. +These are the scientists who are laying the foundation for the future of +the mind. For their ideas to be incorporated into this book, I made only +two requirements: (1) their predictions must rigorously obey the laws of +physics; and (2) prototypes must exist to show proof-of-principle for +these far-reaching ideas. + +TOUCHED BY MENTAL ILLN ESS" +"TOUCHED BY MENTAL ILLN ESS + +I once wrote a biography of Albert Einstein, called Einstein’s Cosmos, and +had to delve into the minute details of his private life. I had known that +Einstein’s youngest son was afflicted with schizophrenia, but did not +realize the enormous emotional toll that it had taken on the great +scientist’s life. Einstein was also touched by mental illness in another +way; one of his closest colleagues was the physicist Paul Ehrenfest, who +helped Einstein create the theory of general relativity. After suffering +bouts of depression, Ehrenfest tragically killed his own son, who had +Down’s syndrome, and then committed suicide. Over the years, I have +found that many of my colleagues and friends have struggled to manage +mental illness in their families." +"Mental illness has also deeply touched my own life. Several years ago, +my mother died after a long battle with Alzheimer’s disease. It was +heartbreaking to see her gradually lose her memories of her loved ones, +to gaze into her eyes and realize that she did not know who I was. I +could see the glimmer of humanity slowly being extinguished. She had +spent a lifetime struggling to raise a family, and instead of enjoying her +golden years, she was robbed of all the memories she held dear. + +As the baby boomers age, the sad experience that I and many others +have had will be repeated across the world. My wish is that rapid +advances in neuroscience will one day alleviate the suffering felt by +those afflicted with mental illness and dementia. + + WHAT IS DRIVING THIS REVOLUTION?" +"WHAT IS DRIVING THIS REVOLUTION? + +The data pouring in from brain scans are now being decoded, and the +progress is stunning. Several times a year, headlines herald a fresh +breakthrough. It took 350 years, since the invention of the telescope, to +enter the space age, but it has taken only fifteen years since the +introduction of the MRI and advanced brain scans to actively connect +the brain to the outside world. Why so quickly , and how much is there to +come?" +"Part of this rapid progress has occurred because physicists today have +a good understanding of electromagnetism, which governs the electrical +signals racing through our neurons. The mathematical equations of +James Clerk Maxwell, which are used to calculate the physics of +antennas, radar, radio receivers, and microwave towers, form the very +cornerstone of MRI technology. It took centuries to finally solve the +secret of electromagnetism, but neuroscience can enjoy the fruits of this +grand endeavor. In Book I, I will survey the history of the brain and +explain how a galaxy of new instruments has left the physics labs and +given us glorious color pictures of the mechanics of thought. Because +consciousness plays so central a role in any discussion of the mind, I also +give a physicist’s perspective, offering a definition of consciousness that +includes the animal kingdom as well. In fact, I provide a ranking of +consciousness, showing how it is possible to assign a number to various" +"consciousness, showing how it is possible to assign a number to various +types of consciousness." +"But to fully answer the question of how this technology will advance, +we also have to look at Moore’s law, which states that computer power +doubles every two years. I often surprise people with the simple fact that +your cell phone today has more computer power than all of NASA when +it put two men on the moon in 1969. Computers are now powerful +enough to record the electrical signals emanating from the brain and +partially decode them into a familiar digital language. This makes it +possible for the brain to directly interface with computers to control any +object around it. The fast-growing field is called BMI (brain-machine +interface), and the key technology is the computer. In Book II, I’ll +explore this new technology, which has made recording memories, mind +reading, videotaping our dreams, and telekinesis possible." +"In Book III, I’ll investigate alternate forms of consciousness, from +dreams, drugs, and mental illness to robots and even aliens from outer +space. Here we’ll also learn about the potential to control and +manipulate the brain to manage diseases such as depression, Parkinson’s, +Alzheimer’s, and many more. I will also elaborate on the Brain Research +Through Advancing Innovative Neurotechnologies (or BRAIN) project + + announced by President Obama, and the Human Brain Project of the +European Union, which will potentially allocate billions of dollars to +decode the pathways of the brain, all the way down to the neural level. +These two crash programs will undoubtedly open up entirely new +research areas, giving us new ways to treat mental illness and also +revealing the deepest secrets of consciousness." +"After we have given a definition of consciousness, we can use it to +explore nonhuman consciousness as well (i.e., the consciousness of +robots). How advanced can robots become? Can they have emotions? +Will they pose a threat? And we can also explore the consciousness of +aliens, who may have goals totally different from ours. + +In the Appendix, I will discuss perhaps the strangest idea in all of +science, the concept from quantum physics that consciousness may be +the fundamental basis for reality. + +There is no shortage of proposals for this exploding field. Only time +will tell which ones are mere pipe dreams created by the overheated +imagination of science-fiction writers and which ones represent solid +avenues for future scientific research. Progress in neuroscience has been +astronomical, and in many ways the key has been modern physics, + +which uses the full power of the electromagnetic and nuclear forces to +probe the great secrets hidden within our minds." +"I should stress that I am not a neuroscientist. I am a theoretical +physicist with an enduring interest in the mind. I hope that the vantage +point of a physicist can help further enrich our knowledge and give a +fresh new understanding of the most familiar and alien object in the +universe: our mind. + +But given the dizzying pace with which radically new perspectives are +being developed, it is important that we have a firm grasp on how the +brain is put together. + +So let us first discuss the origins of modern neuroscience, which some +historians believe began when an iron spike sailed through the brain of a +certain Phineas Gage. This seminal event set off a chain reaction that +helped open the brain to serious scientific investigation. Although it was +an unfortunate event for Mr. Gage, it paved the way for modern science. + +BOOK I THE MIND AND CONSCIOUSNESS + +My fundamental premise about the brain is that its workings—" +"BOOK I THE MIND AND CONSCIOUSNESS + +My fundamental premise about the brain is that its workings— + + what we sometimes call “mind”—are a consequence of its +anatomy and physiology, and nothing more. + +—CARL SAGAN + +1 UNLOCKING THE MIND + +In 1848, Phineas Gage was working as a railroad foreman in Vermont, +when dynamite accidentally went off, propelling a three-foot, seven-inch +spike straight into his face, through the front part of his brain, and out +the top of his skull, eventually landing eighty feet away. His fellow +workers, shocked to see part of their foreman’s brain blown off, +immediately called for a doctor. To the workers’ (and even the doctor’s) +amazement, Mr. Gage did not die on-site." +"He was semiconscious for weeks, but eventually made what seemed +like a full recovery. (A rare photograph of Gage surfaced in 2009, +showing a handsome, confident man, with an injury to his head and left +eye, holding the iron rod.) But after this incident, his coworkers began to +notice a sharp change in his personality. A normally cheerful, helpful +foreman, Gage became abusive, hostile, and selfish. Ladies were warned +to stay clear of him. Dr. John Harlow, the doctor who treated him, +observed that Gage was “capricious and vacillating, devising many plans +of future operations, which are no sooner arranged than they are +abandoned in turn for others appearing more feasible. A child in his +intellectual capacity and manifestations, yet with the animal passions of +a strong man.” Dr. Harlow noted that he was “radically changed” and +that his fellow workers said that “he was no longer Gage.” After Gage’s +death in 1860, Dr. Harlow preserved both his skull and the rod that had" +"death in 1860, Dr. Harlow preserved both his skull and the rod that had +smashed into it. Detailed X-ray scans of the skull have since confirmed +that the iron rod caused massive destruction in the area of the brain +behind the forehead known as the frontal lobe, in both the left and right +cerebral hemispheres." +"This incredible accident would not only change the life of Phineas +Gage, it would alter the course of science as well. Previously, the +dominant thinking was that the brain and the soul were two separate +entities, a philosophy called dualism. But it became increasingly clear +that damage to the frontal lobe of his brain had caused abrupt changes + +in Gage’s personality. This, in turn, created a paradigm shift in scientific +thinking: perhaps specific areas of the brain could be traced to certain +behaviors. + + broca’s brain" +"broca’s brain + +In 1861, just a year after Gage’s death, this view was further cemented +through the work of Pierre Paul Broca, a physician in Paris who +documented a patient who appeared normal except that he had a severe +speech deficit. The patient could understand and comprehend speech +perfectly, but he could utter only one sound, the word “tan.” After the +patient died, Dr. Broca confirmed during the autopsy that the patient +suffered from a lesion in his left temporal lobe, a region of the brain near +his left ear. Dr. Broca would later confirm twelve similar cases of +patients with damage to this specific area of the brain. Today patients +who have damage to the temporal lobe, usually in the left hemisphere, +are said to suffer from Broca’s aphasia. (In general, patients with this +disorder can understand speech but cannot say anything, or else they +drop many words when speaking.)" +"Soon afterward, in 1874, German physician Carl Wernicke described +patients who suffered from the opposite problem. They could articulate +clearly, but they could not understand written or spoken speech. Often +these patients could speak fluently with correct grammar and syntax, but +with nonsensical words and meaningless jargon. Sadly, these patients +often didn’t know they were spouting gibberish. Wernicke confirmed +after performing autopsies that these patients had suffered damage to a +slightly different area of the left temporal lobe. + +The works of Broca and Wernicke were landmark studies in +neuroscience, establishing a clear link between behavioral problems, +such as speech and language impairment, and damage to specific regions +of the brain." +"Another breakthrough took place amid the chaos of war. Throughout +history, there were many religious taboos prohibiting the dissection of +the human body, which severely restricted progress in medicine. In +warfare, however, with tens of thousands of bleeding soldiers dying on +the battlefield, it became an urgent mission for doctors to develop any + +medical treatment that worked. During the Prusso-Danish War in 1864, +German doctor Gustav Fritsch treated many soldiers with gaping wounds +to the brain and happened to notice that when he touched one +hemisphere of the brain, the opposite side of the body often twitched. +Later Fritsch systematically showed that, when he electrically stimulated +the brain, the left hemisphere controlled the right side of the body, and +vice versa. This was a stunning discovery, demonstrating that the brain +was basically electrical in nature and that a particular region of the +brain controlled a part on the other side of the body. (Curiously, the use" +"of electrical probes on the brain was first recorded a couple of thousand +years earlier by the Romans. In the year A.D. 43, records show that the +court doctor to the emperor Claudius used electrically charged torpedo +fish, which were applied to the head of a patient suffering from severe +headaches.) + +The realization that there were electrical pathways connecting the +brain to the body wasn’t systematically analyzed until the 1930s, when +Dr. Wilder Penfield began working with epilepsy patients, who often +suffered from debilitating convulsions and seizures that were potentially +life-threatening. For them, the last option was to have brain surgery, +which involved removing parts of the skull and exposing the brain. +(Since the brain has no pain sensors, a person can be conscious during +this entire procedure, so Dr. Penfield used only a local anesthetic during +the operation.)" +"Dr. Penfield noticed that when he stimulated certain parts of the +cortex with an electrode, different parts of the body would respond. He +suddenly realized that he could draw a rough one-to-one correspondence +between specific regions of the cortex and the human body. His +drawings were so accurate that they are still used today in almost +unaltered form. They had an immediate impact on both the scientific +community and the general public. In one diagram, you could see which +region of the brain roughly controlled which function, and how +important each function was. For example, because our hands and +mouth are so vital for survival, a considerable amount of brain power is +devoted to controlling them, while the sensors in our back hardly +register at all. + +Furthermore, Penfield found that by stimulating parts of the temporal +lobe, his patients suddenly relived long-forgotten memories in a crystal-" +"clear fashion. He was shocked when a patient, in the middle of brain +surgery, suddenly blurted out, “It was like ... standing in the doorway at +[my] high school.... I heard my mother talking on the phone, telling my +aunt to come over that night.” Penfield realized that he was tapping into +memories buried deep inside the brain. When he published his results in +1951, they created another transformation in our understanding of the +brain. + +Figure 1. This is the map of the motor cortex that was created by Dr. Wilder Penfield, showing which +region of the brain + +controls which part of the body, (illustration credit 1.1) + + A MAP OF THE BRAIN + +By the 1950s and ’60s, it was possible to create a crude map of the brain, +locating different regions and even identifying the functions of a few of +them." +"In Figure 2, we see the neocortex, which is the outer layer of the +brain, divided into four lobes. It is highly developed in humans. All the +lobes of the brain are devoted to processing signals from our senses, +except for one: the frontal lobe, located behind the forehead. The +prefrontal cortex, the foremost part of the frontal lobe, is where most +rational thought is processed. The information you are reading right now +is being processed in your prefrontal cortex. Damage to this area can +impair your ability to plan or contemplate the future, as in the case of +Phineas Gage. This is the region where information from our senses is +evaluated and a future course of action is carried out. + +FRONTAL +LOBE + +PARIETAL +LOBE + +OCCIPITAL + +LOBE + +TEMPORAL + +LOBE + + Figure 2. The four lobes of the neocortex of the brain are responsible for different, though related, +functions, (illustration + +credit 1.2)" +"credit 1.2) + +The parietal lobe is located at the top of our brains. The right +hemisphere controls sensory attention and body image; the left +hemisphere controls skilled movements and some aspects of language. +Damage to this area can cause many problems, such as difficulty in +locating parts of your own body. + +The occipital lobe is located at the very back of the brain and +processes visual information from the eyes. Damage to this area can +cause blindness and visual impairment. + +The temporal lobe controls language (on the left side only), as well as +the visual recognition of faces and certain emotional feelings. Damage to +this lobe can leave us speechless or without the ability to recognize +familiar faces. + +THE EVOLVING BRAIN" +"THE EVOLVING BRAIN + +When you look at other organs of the body, such as our muscles, bones, +and lungs, there seems to be an obvious rhyme and reason to them that +we can immediately see. But the structure of the brain might seem +slapped together in a rather chaotic fashion. In fact, trying to map the +brain has often been called “cartography for fools.”" +"To make sense of the seemingly random structure of the brain, in 1967 +Dr. Paul MacLean of the National Institute of Mental Health applied +Charles Darwin’s theory of evolution to the brain. He divided the brain +into three parts. (Since then, studies have shown that there are +refinements to this model, but we will use it as a rough organizing +principle to explain the overall structure of the brain.) First, he noticed +that the back and center part of our brains, containing the brain stem, +cerebellum, and basal ganglia, are almost identical to the brains of +reptiles. Known as the “reptilian brain,” these are the oldest structures of +the brain, governing basic animal functions such as balance, breathing, +digestion, heartbeat, and blood pressure. They also control behaviors +such as fighting, hunting, mating, and territoriality, which are necessary +for survival and reproduction. The reptilian brain can be traced back +about 500 million years. (See Figure 3.)" +"But as we evolved from reptiles to mammals, the brain also became +more complex, evolving outward and creating entirely new structures. + + Here we encounter the “mammalian brain,” or the limbic system, which +is located near the center of the brain, surrounding parts of the reptilian +brain. The limbic system is prominent among animals living in social +groups, such as the apes. It also contains structures that are involved in +emotions. Since the dynamics of social groups can be quite complex, the +limbic system is essential in sorting out potential enemies, allies, and +rivals. + +HUMAN + +BRAIN + +Hypothalamus + +MAMMALIAN +L BRAIN . + +REPTILIAN + +BRAIN + +Corpus callosum + +Cingulate gyrus + +Frontal lobe + +Hippocampus + +Forn + +Cerebellum + +Brain stem + +Pituitary + + gland" +"Frontal lobe + +Hippocampus + +Forn + +Cerebellum + +Brain stem + +Pituitary + + gland + +Figure 3. The evolutionary history of the brain, with the reptilian brain, the limbic system (the +mammalian brain), and the +neocortex (the human brain). Roughly speaking, one can argue that the path of our brain’s evolution +passed from the +reptilian brain to the mammalian brain to the human brain, (illustration credit 1.3) + +The different parts of the limbic system that control behaviors crucial +for social animals are: + +• The hippocampus. This is the gateway to memory, where short-term +memories are processed into long-term memories. Its name means +“seahorse,” which describes its strange shape. Damage here will +destroy the ability to make new long-term memories. You are left a +prisoner of the present. + +• The amygdala. This is the seat of emotions, especially fear, where +emotions are first registered and generated. Its name means +“almond.”" +"• The thalamus. This is like a relay station, gathering sensory signals +from the brain stem and then sending them out to the various +cortices. Its name means “inner chamber.” + +• The hypothalamus. This regulates body temperature, our circadian +rhythm, hunger, thirst, and aspects of reproduction and pleasure. It +lies below the thalamus—hence its name. + +Finally, we have the third and most recent region of the mammalian +brain, the cerebral cortex, which is the outer layer of the brain. The +latest evolutionary structure within the cerebral cortex is the neocortex +(meaning “new bark”), which governs higher cognitive behavior. It is +most highly developed in humans: it makes up 80 percent of our brain’s +mass, yet is only as thick as a napkin. In rats the neocortex is smooth, +but it is highly convoluted in humans, which allows a large amount of +surface area to be crammed into the human skull." +"In some sense, the human brain is like a museum containing remnants +of all the previous stages in our evolution over millions of years, +exploding outward and forward in size and function. (This is also +roughly the path taken when an infant is born. The infant brain expands +outward and toward the front, perhaps mimicking the stages of our +evolution.) + +Although the neocortex seems unassuming, looks are deceiving. Under +a microscope you can appreciate the intricate architecture of the brain. +The gray matter of the brain consists of billions of tiny brain cells called +neurons. Like a gigantic telephone network, they receive messages from +other neurons via dendrites, which are like tendrils sprouting from one +end of the neuron. At the other end of the neuron, there is a long fiber +called the axon. Eventually the axon connects to as many as ten" +"thousand other neurons via their dendrites. At the juncture between the +two, there is a tiny gap called the synapse. These synapses act like gates, +regulating the flow of information within the brain. Special chemicals +called neurotransmitters can enter the synapse and alter the flow of +signals. Because neurotransmitters like dopamine, serotonin, and +noradrenaline help control the stream of information moving across the +myriad pathways of the brain, they exert a powerful effect on our +moods, emotions, thoughts, and state of mind. (See Figure 4.) + +This description of the brain roughly represented the state of +knowledge through the 1980s. In the 1990s, however, with the +introduction of new technologies from the field of physics, the +mechanics of thought began to be revealed in exquisite detail, +unleashing the current explosion of scientific discovery. One of the +workhorses of this revolution has been the MRI machine." +"Figure 4. Diagram of a neuron. Electrical signals travel along the axon of the neuron until they hit the +synapse. +Neurotransmitters can regulate the flow of electrical signals past the synapse, (illustration credit 1.4) + +THE MRI: WINDOW INTO THE BRAIN + +To understand the reason why this radical new technology has helped +decode the thinking brain, we have to turn our attention to some basic +principles of physics. + +Radio waves, a type of electromagnetic radiation, can pass right + + through tissue without doing damage. MRI machines take advantage of +this fact, allowing electromagnetic waves to freely penetrate the skull. In +the process, this technology has given us glorious photographs of +something once thought to be impossible to capture: the inner workings + +of the brain as it experiences sensations and emotions. Watching the +dance of lights flickering in a MRI machine, one can trace out the +thoughts moving within the brain. It’s like being able to see the inside of +a clock as it ticks." +"The first thing you notice about an MRI machine is the huge, +cylindrical magnetic coils, which can produce a magnetic field twenty to +sixty thousand times greater than the strength of Earth’s. The giant +magnet is one of the principal reasons why an MRI machine can weigh a +ton, fill up an entire room, and cost several million dollars. (MRI +machines are safer than X-ray machines because they don’t create +harmful ions. CT scans, which can also create 3-D pictures, flood the +body with many times the dosage from an ordinary X-ray, and hence +have to be carefully regulated. By contrast, MRI machines are safe when +used properly. One problem, however, is the carelessness of workers. +The magnetic field is powerful enough to send tools hurling through the +air at high velocity when turned on at the wrong time. People have been +injured and even killed in this way.)" +"MRI machines work as follows: Patients lie flat and are inserted into a +cylinder containing two large coils, which create the magnetic field. +When the magnetic field is turned on, the nuclei of the atoms inside your +body act very much like a compass needle: they align horizontally along +the direction of the field. Then a small pulse of radio energy is +generated, which causes some of the nuclei in our body to flip upside +down. When the nuclei later revert back to their normal position, they +emit a secondary pulse of radio energy, which is then analyzed by the +MRI machine. By analyzing these tiny “echoes,” one can then reconstruct +the location and nature of these atoms. Like a bat, which uses echoes to +determine the position of objects in its path, the echoes created by the +MRI machine allow scientists to re-create a remarkable image of the +inside of the brain. Computers then reconstruct the position of the +atoms, giving us beautiful diagrams in three dimensions." +"When MRIs were originally introduced, they were able to show the +static structure of the brain and its various regions. However, in the mid- +1990s, a new type of MRI was invented, called “functional” MRI, or +fMRI, which detected the presence of oxygen in the blood in the brain. +(For different types of MRI machines, scientists sometimes put a +lowercase letter in front of “MRI,” but we will use the abbreviation MRI + + to denote all the various types of MRI machines.) MRI scans cannot +directly detect the flow of electricity in the neurons, but since oxygen is +necessary to provide the energy for the neurons, oxygenated blood can +indirectly trace the flow of electrical energy in the neurons and show +how various regions of the brain interact with one another." +"Already these MRI scans have definitively disproven the idea that +thinking is concentrated in a single center. Instead, one can see electrical +energy circulating across different parts of the brain as it thinks. By +tracing the path taken by our thoughts, MRI scans have shed new light +into the nature of Alzheimer’s, Parkinson’s, schizophrenia, and a host of +other mental diseases. + +The great advantage of MRI machines is their exquisite ability to +locate minute parts of the brain, down to a fraction of a millimeter in +size. An MRI scan will create not just dots on a two-dimensional screen, +called pixels, but dots in three-dimensional space, called “voxels,” +yielding a bright collection of tens of thousands of colored dots in 3-D, in +the shape of a brain." +"Since different chemical elements respond to different frequencies of +radio, you can change the frequency of the radio pulse and therefore +identify different elements of the body. As noted, fMRI machines zero in +on the oxygen atom contained within blood in order to measure blood +flow, but MRI machines can also be tuned to identify other atoms. In just +the last decade, a new form of MRI was introduced called “diffusion +tensor imaging” MRI, which detects the flow of water in the brain. Since +water follows the neural pathways of the brain, DTI yields beautiful +pictures that resemble networks of vines growing in a garden. Scientists +can now instantly determine how certain parts of the brain are hooked +up with other parts." +"There are a couple of drawbacks to MRI technology, however. +Although they are unparalleled in spatial resolution, locating voxels +down to the size of a pinpoint in three dimensions, MRIs are not that +good in temporal resolution. It takes almost a full second to follow the +path of blood in the brain, which may not sound like a lot, but +remember that electrical signals travel almost instantly throughout the +brain, and hence MRI scans can miss some of the intricate details of +thought patterns. + +Another snag is the cost, which runs in the millions of dollars, so + +doctors often have to share the machines. But like most technology, +developments should bring down the cost over time." +"In the meantime, exorbitant costs haven’t stalled the hunt for +commercial applications. One idea is to use MRI scans as lie detectors, +which, according to some studies, can identify lies with 95 percent +accuracy or higher. The level of accuracy is still controversial, but the +basic idea is that when a person tells a lie, he simultaneously has to +know the truth, concoct the lie, and rapidly analyze the consistency of +this lie with previously known facts. Today some companies are claiming +that MRI technology shows that the prefrontal and parietal lobes light up +when someone tells a lie. More specifically, the “orbitofrontal cortex” +(which can serve, among other functions, as the brain’s “fact-checker” to +warn us when something is wrong) becomes active. This area is located +right behind the orbits of our eyes, and hence the name. The theory goes +that the orbitofrontal cortex understands the difference between the +truth and a lie and kicks into overdrive as a result. (Other areas of the" +"truth and a lie and kicks into overdrive as a result. (Other areas of the +brain also light up when someone tells a lie, such as the superiormedial +and inferolateral prefrontal cortices, which are involved in cognition.)" +"Already there are several commercial firms offering MRI machines as +lie detectors, and cases involving these machines are entering the court +system. But it’s important to note that these MRI scans indicate increased +brain activity only in certain areas. While DNA results can sometimes +have an accuracy of one part in 10 billion or better, MRI scans cannot, +because it takes many areas of the brain to concoct a lie, and these same +areas of the brain are responsible for processing other kinds of thoughts +as well. + +EEG SCANS + +Another useful tool to probe deep inside the brain is the EEG, the +electroencephalogram. The EEG was introduced all the way back in +1924, but only recently has it been possible to employ computers to +make sense out of all the data pouring in from each electrode. + +To use the EEG machine, the patient usually puts on a futuristic- +looking helmet with scores of electrodes on the surface. (More advanced +versions place a hairnet over the head containing a series of tiny" +"electrodes.) These electrodes detect the tiny electrical signals that are +circulating in the brain. + +(illustration credit 1.5) + + Figure 5. At the top, we see an image taken by a functional MRI machine, showing regions of high +mental activity. In the + +bottom image, we see the flowerlike pattern created by a diffusion MRI machine, which can follow the +neural pathways + +and connections of the brain, (illustration credit 1.5a)" +"An EEG scan differs from an MRI scan in several crucial ways. The +MRI scan, as we have seen, shoots radio pulses into the brain and then +analyzes the “echoes” that come back. This means you can vary the +radio pulse to select different atoms for analysis, making it quite +versatile. The EEG machine, however, is strictly passive; that is, it +analyzes the tiny electromagnetic signals the brain naturally emits. The +EEG excels at recording the broad electromagnetic signals that surge +across the entire brain, which allows scientists to measure the overall +activity of the brain as it sleeps, concentrates, relaxes, dreams, etc. +Different states of consciousness vibrate at different frequencies. For +example, deep sleep corresponds to delta waves, which vibrate at .1 to 4 +cycles per second. Active mental states, such as problem solving, +correspond to beta waves, vibrating from 12 to 30 cycles per second. +These vibrations allow various parts of the brain to share information" +"These vibrations allow various parts of the brain to share information +and communicate with one another, even if they are located on opposite +sides of the brain. And while MRI scans measuring blood flow can be +taken only several times a second, EEG scans measure electrical activity +instantly." +"The greatest advantage of the EEG scan, though, is its convenience +and cost. Even high school students have done experiments in their +living rooms with EEG sensors placed over their heads. + +However, the main drawback to the EEG, which has held up its +development for decades, is its very poor spatial resolution. The EEG +picks up electrical signals that have already been diffused after passing +through the skull, making it difficult to detect abnormal activity when it +originates deep in the brain. Looking at the output of the muddled EEG +signals, it is almost impossible to say for sure which part of the brain +created it. Furthermore, slight motions, like moving a finger, can distort +the signal, sometimes rendering it useless. + +PET SCANS + + Yet another useful tool from the world of physics is the positron +emission topography (PET) scan, which calculates the flow of energy in" +"the brain by locating the presence of glucose, the sugar molecule that +fuels cells. Like the cloud chamber I made as a high school student, PET +scans make use of the subatomic particles emitted from sodium-22 +within the glucose. To start the PET scan, a special solution containing +slightly radioactive sugar is injected into the patient. The sodium atoms +inside the sugar molecules have been replaced by radioactive sodium-22 +atoms. Every time a sodium atom decays, it emits a positive electron, or +positron, which is easily detected by sensors. By following the path of +the radioactive sodium atoms in sugar, one can then trace out the energy +flow within the living brain. + +The PET scan shares many of the same advantages of MRI scans but +does not have the fine spatial resolution of an MRI photo. However, +instead of measuring blood flow, which is only an indirect indicator of +energy consumption in the body, PET scans measure energy +consumption, so it is more closely related to neural activity." +"There is another drawback to PET scans, however. Unlike MRI and +EEG scans, PET scans are slightly radioactive, so patients cannot +continually take them. In general, a person is not allowed to have a PET +scan more than once a year because of the risk from radiation. + +MAGNETISM IN THE BRAIN + +Within the last decade, many new high-tech devices have entered the +tool kit of neuroscientists, including the transcranial electromagnetic +scanner (TES), magnetoencephalography (MEG), near-infrared +spectroscopy (NIRS), and optogenetics, among others." +"In particular, magnetism has been used to systematically shut down +specific parts of the brain without cutting it open. The basic physics +behind these new tools is that a rapidly changing electric field can create +a magnetic field, and vice versa. MEGs passively measure the magnetic +fields produced by the changing electric fields of the brain. These +magnetic fields are weak and extremely tiny, only a billionth of Earth’s +magnetic field. Like the EEG, the MEG is extremely good at time +resolution, down to a thousandth of a second. Its spatial resolution, +however, is only a cubic centimeter. + +Unlike the passive measurement of the MEG, the TES generates a large + + pulse of electricity, which in turn creates a burst of magnetic energy. +The TES is placed next to the brain, so the magnetic pulse penetrates the +skull and creates yet another electric pulse inside the brain. This +secondary electrical pulse, in turn, is sufficient to turn off or dampen the +activity of selected areas of the brain." +"Historically, scientists had to rely on strokes or tumors to silence +certain parts of the brain and hence determine what they do. But with +the TES, one can harmlessly turn off or dampen parts of the brain at will. +By shooting magnetic energy at a particular spot in the brain, one can +determine its function by simply watching how a person’s behavior has +changed. (For example, by shooting magnetic pulses into the left +temporal lobe, one can see that this adversely affects our ability to talk.)" +"One potential drawback of the TES is that these magnetic fields do not +penetrate very far into the interior of the brain (because magnetic fields +decrease much faster than the usual inverse square law for electricity). +TES is quite useful in turning off parts of the brain near the skull, but the +magnetic field cannot reach important centers located deep in the brain, +such as the limbic system. But future generations of TES devices may +overcome this technical problem by increasing the intensity and +precision of the magnetic field. + +Wire coil + +Pulsed magnetic field + +Stimulated +brain region + +Positioning + +frame + +Figure 6. We see the transcranial electromagnetic scanner and the magnetoencephalograph, which uses +magnetism rather +than radio waves to penetrate the skull and determine the nature of thoughts within the brain. +Magnetism can +temporarily silence parts of the brain, allowing scientists to safely determine how these regions perform +without relying" +"on stroke victims, (illustration credit 1.6) + +DEEP BRAIN STIMULATION + +Yet another tool that has proven vital to neurologists is deep brain +stimulation (DBS). The probes originally used by Dr. Penfield were +relatively crude. Today these electrodes can be hairlike and reach +specific areas of the brain deep within its interior. Not only has DBS +allowed scientists to locate the function of various parts of the brain, it +can also be used to treat mental disorders. DBS has already proven its + +worth with Parkinson’s disease, in which certain regions of the brain are +overactive and often create uncontrollable shaking of the hands. + +More recently, these electrodes have targeted a new area of the brain +(called Brodmann’s area number 25) that is often overactive in +depressed patients who do not respond to psychotherapy or drugs. Deep +brain stimulation has given almost miraculous relief after decades of +torment and agony for these long-suffering patients." +"Every year, new uses for deep brain stimulation are being found. In +fact, nearly all the major disorders of the brain are being reexamined in +light of this and other new brain-scanning technologies. This promises to +be an exciting new area for diagnosing and even treating illnesses. + +OPTOGENETICS—LIGHTING UP THE BRAIN + +But perhaps the newest and most exciting instrument in the neurologist’s +tool kit is optogenetics, which was once considered science fiction. Like +a magic wand, it allows you to activate certain pathways controlling +behavior by shining a light beam on the brain. + +Incredibly, a light-sensitive gene that causes a cell to fire can be +inserted, with surgical precision, directly into a neuron. Then, by turning +on a light beam, the neuron is activated. More importantly, this allows +scientists to excite these pathways, so that you can turn on and off +certain behaviors by flicking a switch." +"Although this technology is only a decade old, optogenetics has +already proven successful in controlling certain animal behaviors. By + + turning on a light switch, it is possible to make fruit flies suddenly fly +off, worms stop wiggling, and mice run around madly in circles. Monkey +trials are now beginning, and even human trials are in discussion. There +is great hope that this technology will have a direct application in +treating disorders like Parkinson’s and depression. + +THE TRANSPARENT BRAIN + +Like optogenetics, another spectacular new development is making the +brain fully transparent so that its neural pathways are exposed to the +naked eye. In 2013, scientists at Stanford University announced that + +they had successfully made the entire brain of a mouse transparent, as +well as parts of a human brain. The announcement was so stunning that +it made the front page of the New York Times, with the headline “Brain +as Clear as Jell-0 for Scientists to Explore.”" +"At the cellular level, cells seen individually are transparent, with all +their microscopic components fully exposed. However, once billions of +cells come together to form organs like the brain, the addition of lipids +(fats, oils, waxes, and chemicals not soluble in water) helps make the +organ opaque. The key to the new technique is to remove the lipids +while keeping the neurons intact. The scientists at Stanford did this by +placing the brain in hydrogel (a gel-like substance mainly made of +water), which binds to all the brain’s molecules except the lipids. By +placing the brain in a soapy solution with an electric field, the solution +can be flushed out of the brain, carrying along the lipids, leaving the +brain transparent. The addition of dyes can then make the neural +pathways visible. This will help to identify and map the many neural +pathways of the brain." +"Making tissue transparent is not new, but getting precisely the right +conditions necessary to make the entire brain transparent took a lot of +ingenuity. “I burned and melted more than a hundred brains,” confessed +Dr. Kwanghun Chung, one of the lead scientists in the study. The new +technique, called Clarity, can also be applied to other organs (and even +organs preserved years ago in chemicals like formalin). He has already +created transparent livers, lungs, and hearts. This new technique has +startling applications across all of medicine. In particular, it will +accelerate locating the neural pathways of the brain, which is the focus +of intense research and funding. + +FOUR FUNDAMENTAL FORCES" +"FOUR FUNDAMENTAL FORCES + + The success of this first generation of brain scans has been nothing less +than spectacular. Before their introduction, only about thirty or so +regions of the brain were known with any certainty. Now the MRI +machine alone can identify two to three hundred regions of the brain, +opening up entirely new frontiers for brain science. With so many new +scanning technologies being introduced from physics just within the last + +fifteen years, one might wonder: Are there more? The answer is yes, but +they will be variations and refinements of the previous ones, not +radically new technologies. This is because there are only four +fundamental forces—gravitational, electromagnetic, weak nuclear, and +strong nuclear—that rule the universe. (Physicists have tried to find +evidence for a fifth force, but so far all such attempts have failed.)" +"The electromagnetic force, which lights up our cities and represents +the energy of electricity and magnetism, is the source of almost all the +new scanning technologies (with the exception of the PET scan, which is +governed by the weak nuclear force). Because physicists have had over +150 years of experience working with the electromagnetic force, there is +no mystery in creating new electric and magnetic fields, so any new +brain-scanning technology will most likely be a novel modification of +existing technologies, rather than being something entirely new. As with +most technology, the size and cost of these machines will drop, vastly +increasing the widespread use of these sophisticated instruments. +Already physicists are doing the basic calculations necessary to make an +MRI machine fit into a cell phone. At the same time, the fundamental +challenge facing these brain scans is resolution, both spatial and +temporal. The spatial resolution of MRI scans will increase as the" +"temporal. The spatial resolution of MRI scans will increase as the +magnetic field becomes more uniform and as the electronics become +more sensitive. At present, MRI scans can see only dots or voxels within +a fraction of a millimeter. But each dot may contain hundreds of +thousands of neurons. New scanning technology should reduce this even +further. The holy grail of this approach would be to create an MRI-like +machine that could identify individual neurons and their connections." +"The temporal resolution of MRI machines is also limited because they +analyze the flow of oxygenated blood in the brain. The machine itself +has very good temporal resolution, but tracing the flow of blood slows it +down. In the future, other MRI machines will be able to locate different +substances that are more directly connected to the firing of neurons, +thereby allowing real-time analysis of mental processes. No matter how +spectacular the successes of the past fifteen years, then, they were just a +taste of the future. + +NEW MODELS OF THE BRAIN + + Historically, with each new scientific discovery, a new model of the +brain has emerged. One of the earliest models of the brain was the +“homunculus,” a little man who lived inside the brain and made all the +decisions. This picture was not very helpful, since it did not explain what +was happening in the brain of the homunculus. Perhaps there was a +homunculus hiding inside the homunculus." +"With the arrival of simple mechanical devices, another model of the +brain was proposed: that of a machine, such as a clock, with mechanical +wheels and gears. This analogy was useful for scientists and inventors +like Leonardo da Vinci, who actually designed a mechanical man." +"During the late 1800s, when steam power was carving out new +empires, another analogy emerged, that of a steam engine, with flows of +energy competing with one another. This hydraulic model, historians +have conjectured, affected Sigmund Freud’s picture of the brain, in +which there was a continual struggle between three forces: the ego +(representing the self and rational thought), the id (representing +repressed desires), and the superego (representing our conscience). In +this model, if too much pressure built up because of a conflict among +these three, there could be a regression or general breakdown of the +entire system. This model was ingenious, but as even Freud himself +admitted, it required detailed studies of the brain at the neuronal level, +which would take another century." +"Early in the last century, with the rise of the telephone, another +analogy surfaced—that of a giant switchboard. The brain was a mesh of +telephone lines connected into a vast network. Consciousness was a long +row of telephone operators sitting in front of a large panel of switches, +constantly plugging and unplugging wires. Unfortunately, this model +said nothing about how these messages were wired together to form the +brain. + +With the rise of the transistor, yet another model became fashionable: +the computer. The old-fashioned switching stations were replaced by +microchips containing hundreds of millions of transistors. Perhaps the +“mind” was just a software program running on “wetware” (i.e., brain +tissue rather than transistors). This model is an enduring one, even +today, but it has limitations. The transistor model cannot explain how +the brain performs computations that would require a computer the size +of New York City. Plus the brain has no programming, no Windows" +"operating system or Pentium chip. (Also, a PC with a Pentium chip is +extremely fast, but it has a bottleneck. All calculations must pass + + through this single processor. The brain is the opposite. The firing of +each neuron is relatively slow, but it more than makes up for this by +having 100 billion neurons processing data simultaneously. Therefore a +slow parallel processor can trump a very fast single processor.) + +The most recent analogy is that of the Internet, which lashes together +billions of computers. Consciousness, in this picture, is an “emergent” +phenomenon, miraculously arising out of the collective action of billions +of neurons. (The problem with this picture is that it says absolutely +nothing about how this miracle occurs. It brushes all the complexity of +the brain under the rug of chaos theory.)" +"No doubt each of these analogies has kernels of truth, but none of +them truly captures the complexity of the brain. However, one analogy +for the brain that I have found useful (albeit still imperfect) is that of a +large corporation. In this analogy, there is a huge bureaucracy and lines +of authority, with vast flows of information channeled between different +offices. But the important information eventually winds up at the +command center with the CEO. There the final decisions are made. + +If this analogy of the brain to a large corporation is valid, then it +should be able to explain certain peculiar features of the brain:" +"• Most information is “subconscious” —that is, the CEO is blissfully +unaware of the vast, complex information that is constantly flowing +inside the bureaucracy. In fact, only a tiny amount of information +finally reaches the desk of the CEO, who can be compared to the +prefrontal cortex. The CEO just has to know information important +enough to get his attention; otherwise, he would be paralyzed by an +avalanche of extraneous information. + +This arrangement is probably a by-product of evolution, since our +ancestors would have been overwhelmed with superfluous, +subconscious information flooding their brains when facing an +emergency. We are all mercifully unaware of the trillions of +calculations being processed in our brains. Upon encountering a +tiger in the forest, one does not have to be bothered with the status +of our stomach, toes, hair, etc. All one has to know is how to run. + +• “Emotions” are rapid decisions made independently at a lower" +"• “Emotions” are rapid decisions made independently at a lower + +level. Since rational thought takes many seconds, this means that it +is often impossible to make a reasoned response to an emergency; +hence lower-level brain regions must rapidly assess the situation and +make a decision, an emotion, without permission from the top. + +So emotions (fear, anger, horror, etc.) are instantaneous red flags + + made at a lower level, generated by evolution, to warn the +command center of possibly dangerous or serious situations. We +have little conscious control over emotions. For example, no matter +how much we practice giving a speech to a large audience, we still +feel nervous. + +Rita Carter, author of Mapping the Mind, writes, “Emotions are not +feelings at all but a set of body-rooted survival mechanisms that +have evolved to turn us away from danger and propel us forward to +things that may be of benefit.” + +• There is a constant clamoring for the attention of the CEO." +"• There is a constant clamoring for the attention of the CEO. + +There is no single homunculus, CPU, or Pentium chip making +decisions; instead, the various subcenters within the command +center are in constant competition with one another, vying for the +attention of the CEO. So there is no smooth, steady continuity of +thought, but the cacophony of different feedback loops competing +with one another. The concept of “I,” as a single, unified whole +making all decisions continuously, is an illusion created by our own +subconscious minds. + +Mentally we feel that our mind is a single entity, continuously and +smoothly processing information, totally in charge of our decisions. +But the picture emerging from brain scans is quite different from the +perception we have of our own mind. + +MIT professor Marvin Minsky, one of the founding fathers of +artificial intelligence, told me that the mind is more like a “society +of minds,” with different submodules, each trying to compete with +the others." +"When I interviewed Steven Pinker, a psychologist at Harvard +University, I asked him how consciousness emerges out of this mess. +He said that consciousness was like a storm raging in our brain. He +elaborated on this when he wrote that “the intuitive feeling we have +that there’s an executive T that sits in a control room of our brain, + +scanning the screens of the senses and pushing the buttons of our +muscles, is an illusion. Consciousness turns out to consist of a +maelstrom of events distributed across the brain. These events +compete for attention, and as one process outshouts the others, the +brain rationalizes the outcome after the fact and concocts the +impression that a single self was in charge all along.” + +• Final decisions are made by the CEO in the command center." +"• Final decisions are made by the CEO in the command center. + + Almost all the bureaucracy is devoted to accumulating and +assembling information for the CEO, who meets only with the +directors of each division. The CEO tries to mediate all the +conflicting information pouring into the command center. The buck +stops here. The CEO, located in the prefrontal cortex, has to make +the final decision. While most decisions are made by instinct in +animals, humans make higher-level decisions after sifting through +different bodies of information from our senses. + +• Information flows are hierarchical. Because of the vast amount of +information that must flow upward toward the CEO’s office, or +downward to the support staff, information must be arranged in +complex arrays of nested networks, with many branches. Think of a +pine tree, with the command center on top and a pyramid of +branches flowing downward, branching out into many subcenters." +"There are, of course, differences between a bureaucracy and the +structure of thought. The first rule of any bureaucracy is that “it +expands to fill the space allotted to it.” But wasting energy is a +luxury the brain cannot afford. The brain consumes only about +twenty watts of power (the power of a dim lightbulb), but that is +probably the maximum energy it can consume before the body +becomes dysfunctional. If it generates more heat, it will cause tissue +damage. Therefore the brain is constantly using shortcuts to +conserve energy. We will see throughout this book the clever and +ingenious devices that evolution has crafted, without our +knowledge, to cut corners. + +IS “REALITY” REALLY REAL? + +Everyone knows the expression “seeing is believing.” Yet much of what" +"IS “REALITY” REALLY REAL? + +Everyone knows the expression “seeing is believing.” Yet much of what + +we see is actually an illusion. For example, when we see a typical +landscape, it seems like a smooth, movielike panorama. In reality, there +is a gaping hole in our field of vision, corresponding to the location of +the optic nerve in the retina. We should see this large ugly black spot +wherever we look. But our brains fill in that hole by papering it over, by +averaging it out. This means that part of our vision is actually fake, +generated by our subconscious minds to deceive us. + +Also, we see only the center of our field of vision, called the fovea, +with clarity. The peripheral part is blurry, in order to save energy. But +the fovea is very small. To capture as much information as possible with +the tiny fovea, the eye darts around constantly. This rapid, jiggling +motion of our eyes is called saccades. All this is done subconsciously," +"giving us the false impression that our field of vision is clear and +focused. + +When I was a child and first saw a diagram showing the +electromagnetic spectrum in its true glory, I was shocked. I had been +totally unaware that huge parts of the EM spectrum (e.g., infrared light, +UV light, X-rays, gamma rays) were totally invisible to us. I began to +realize that what I saw with my eyes was only a tiny, crude +approximation of reality. (There is an old saying: “If appearance and +essence were the same thing, there would be no need for science.”) We +have sensors in the retina that can detect only red, green, and blue. This +means that we’ve never actually seen yellow, brown, orange, and a host +of other colors. These colors do exist, but our brain can approximate +each of them only by mixing different amounts of red, green, and blue. +(You can see this if you look at an old color-TV screen very carefully. +You see only a collection of red, green, and blue dots. Color TV is +actually an illusion.)" +"Our eyes also fool us into thinking we can see depth. The retinas of +our eyes are two-dimensional, but because we have two eyes separated +by a few inches, the left and right brain merge these two images, giving +us the false sense of a third dimension. For more distant objects, we can +judge how far an object is by observing how they move when we move +our head. This is called parallax. + +(This parallax explains the fact that children sometimes complain that +“the moon is following me.” Because the brain has difficulty +comprehending the parallax of an object as distant as the moon, it + +appears as if the moon is always a fixed distance “behind” them, but it’s +just an illusion caused by the brain taking a shortcut.) + +THE SPLIT-BRAIN PARADOX" +"THE SPLIT-BRAIN PARADOX + +One way in which this picture, based on the corporate hierarchy of a +company, deviates from the actual structure of the brain can be seen in +the curious case of split-brain patients. One unusual feature of the brain +is that it has two nearly identical halves, or hemispheres, the left and +right. Scientists have long wondered why the brain has this unnecessary +redundancy, since the brain can operate even if one entire hemisphere is +completely removed. No normal corporate hierarchy has this strange +feature. Furthermore, if each hemisphere has consciousness, does this +mean that we have two separate centers of consciousness inside one +skull?" +"Dr. Roger W. Sperry of the California Institute of Technology won the +Nobel Prize in 1981 for showing that the two hemispheres of the brain +are not exact carbon copies of each other, but actually perform different +duties. This result created a sensation in neurology (and also spawned a +cottage industry of dubious self-help books that claim to apply the left- +brain, right-brain dichotomy to your life). + +Dr. Sperry was treating epileptics, who sometimes suffer from grand +mal seizures often caused by feedback loops between the two +hemispheres that go out of control. Like a microphone screeching in our +ears because of a feedback loop, these seizures can become life- +threatening. Dr. Sperry began by severing the corpus callosum, which +connects the two hemispheres of the brain, so that they no longer +communicated and shared information between the left and right side of +the body. This usually stopped the feedback loop and the seizures." +"At first, these split-brain patients seemed perfectly normal. They were +alert and could carry on a natural conversation as if nothing had +happened. But a careful analysis of these individuals showed that +something was very different about them. + +Normally the hemispheres complement each other as thoughts move +back and forth between the two. The left brain is more analytical and +logical. It is where verbal skills are found, while the right brain is more + +holistic and artistic. But the left brain is the dominant one and makes the +final decisions. Commands pass from the left brain to the right brain via +the corpus callosum. But if that connection is cut, it means that the right +brain is now free from the dictatorship of the left brain. Perhaps the +right brain can have a will of its own, contradicting the wishes of the +dominant left brain." +"In short, there could be two wills acting within one skull, sometimes +struggling for control of the body. This creates the bizarre situation +where the left hand (controlled by the right brain) starts to behave +independently of your wishes, as if it were an alien appendage. + +There is one documented case in which a man was about to hug his +wife with one hand, only to find that the other hand had an entirely +different agenda. It delivered a right hook to her face. Another woman +reported that she would pick out a dress with one hand, only to see her +other hand grab an entirely different outfit. Meanwhile, one man had +difficulty sleeping at night thinking that his other rebellious hand might +strangle him. + +At times, split-brain people think they are living in a cartoon, where +one hand struggles to control the other. Physicians sometimes call this + + the Dr. Strangelove syndrome, because of a scene in the movie in which +one hand has to fight against the other hand." +"Dr. Sperry, after detailed studies of split-brain patients, finally +concluded that there could be two distinct minds operating in a single +brain. He wrote that each hemisphere is “indeed a conscious system in +its own right, perceiving, thinking, remembering, reasoning, willing, and +emoting, all at a characteristically human level, and ... both the left and +right hemisphere may be conscious simultaneously in different, even in +mutually conflicting, mental experiences that run along in parallel.”" +"When I interviewed Dr. Michael Gazzaniga of the University of +California, Santa Barbara, an authority on split-brain patients, I asked +him how experiments can be done to test this theory. There are a variety +of ways to communicate separately to each hemisphere without the +knowledge of the other hemisphere. One can, for example, have the +subject wear special glasses on which questions can be shown to each +eye separately, so that directing questions to each hemisphere is easy. +The hard part is trying to get an answer from each hemisphere. Since the +right brain cannot speak (the speech centers are located only in the left + +brain), it is difficult to get answers from the right brain. Dr. Gazzaniga +told me that to find out what the right brain was thinking, he created an +experiment in which the (mute) right brain could “talk” by using +Scrabble letters." +"He began by asking the patient’s left brain what he would do after +graduation. The patient replied that he wanted to become a draftsman. +But things got interesting when the (mute) right brain was asked the +same question. The right brain spelled out the words: “automobile +racer.” Unknown to the dominant left brain, the right brain secretly had +a completely different agenda for the future. The right brain literally had +a mind of its own. + +Rita Carter writes, “The possible implications of this are mind- +boggling. It suggests that we might all be carrying around in our skulls a +mute prisoner with a personality, ambition, and self-awareness quite +different from the day-to-day entity we believe ourselves to be.”" +"Perhaps there is truth to the oft-heard statement that “inside him, +there is someone yearning to be free.” This means that the two +hemispheres may even have different beliefs. For example, the +neurologist V. S. Ramanchandran describes one split-brain patient who, +when asked if he was a believer or not, said he was an atheist, but his +right brain declared he was a believer. Apparently, it is possible to have +two opposing religious beliefs residing in the same brain. Ramachandran +continues: “If that person dies, what happens? Does one hemisphere go + + to heaven and the other go to hell? I don’t know the answer to that.” + +(It is conceivable, therefore, that a person with a split-brain +personality might be both Republican and Democrat at the same time. If +you ask him whom he will vote for, he will give you the candidate of the +left brain, since the right brain cannot speak. But you can imagine the +chaos in the voting booth when he has to pull the lever with one hand.) + +WHO IS IN CHARGE?" +"WHO IS IN CHARGE? + +One person who has spent considerable time and done much research to +understand the problem of the subconscious mind is Dr. David +Eagleman, a neuroscientist at the Baylor College of Medicine. When I +interviewed him, I asked him, If most of our mental processes are + +subconscious, then why are we ignorant of this important fact? He gave +an example of a young king who inherits the throne and takes credit for +everything in the kingdom, but hasn’t the slightest clue about the +thousands of staff, soldiers, and peasants necessary to maintain the +throne." +"Our choice of politicians, marriage partners, friends, and future +occupations are all influenced by things that we are not conscious of. +(For example, it is an odd result, he says, that “people named Denise or +Dennis are disproportionately likely to become dentists, while people +named Laura or Lawrence are more likely to become lawyers, and +people with names like George or Georgina to become geologists.”) This +also means that what we consider to be “reality” is only an +approximation that the brain makes to fill in the gaps. Each of us sees +reality in a slightly different way. For example, he pointed out, “at least +15 percent of human females possess a genetic mutation that gives them +an extra (fourth) type of color photoreceptor—and this allows them to +discriminate between colors that look identical to the majority of us with +a mere three types of color photoreceptors.”" +"Clearly, the more we understand the mechanics of thought, the more +questions arise. Precisely what happens in the command center of the +mind when confronted with a rebellious shadow command center? What +do we mean by “consciousness” anyway, if it can be split in half? And +what is the relationship between consciousness and “self” and “self- +awareness”? + +If we can answer these difficult questions, then perhaps it will pave +the way for understanding nonhuman consciousness, the consciousness +of robots and aliens from outer space, for example, which may be + + entirely different from ours. + +So let us now propose a clear answer to this deceptively complex +question: What is consciousness? + +The mind of man is capable of anything ... because everything +is in it, all the past as well as all the future. + +—JOSEPH CONRAD + +Consciousness can reduce even the most fastidious thinker to +blabbering incoherence. + +—COLIN MCGINN + +2 CONSCIOUSNESS—A PHYSICIST’S VIEWPOINT" +"—COLIN MCGINN + +2 CONSCIOUSNESS—A PHYSICIST’S VIEWPOINT + +The idea of consciousness has intrigued philosophers for centuries, but +it has resisted a simple definition, even to this day. The philosopher +David Chalmers has cataloged more than twenty thousand papers +written on the subject; nowhere in science have so many devoted so +much to create so little consensus. The seventeenth-century thinker +Gottfried Leibniz once wrote, “If you could blow the brain up to the size +of a mill and walk about inside, you would not find consciousness.” + +Some philosophers doubt that a theory of consciousness is even +possible. They claim that consciousness can never be explained since an +object can never understand itself, so we don’t even have the mental +firepower to solve this perplexing question. Harvard psychologist Steven +Pinker writes, “We cannot see ultraviolet light. We cannot mentally +rotate an object in the fourth dimension. And perhaps we cannot solve +conundrums like free will and sentience.”" +"In fact, for most of the twentieth century, one of the dominant theories +of psychology, behaviorism, denied the importance of consciousness +entirely. Behaviorism is based on the idea that only the objective +behavior of animals and people is worthy of study, not the subjective, +internal states of the mind. + +Others have given up trying to define consciousness, and try simply to +describe it. Psychiatrist Giulio Tononi has said, “Everybody knows what +consciousness is: it is what abandons you every night when you fall into +dreamless sleep and returns the next morning when you wake up.” + + Although the nature of consciousness has been debated for centuries, +there has been little resolution. Given that physicists created many of the +inventions that have made the explosive advancements in brain science +possible, perhaps it will be useful to follow an example from physics in +reexamining this ancient question. + +HOW PHYSICISTS UNDERSTAND THE UNIVERSE" +"HOW PHYSICISTS UNDERSTAND THE UNIVERSE + +When a physicist tries to understand something, first he collects data and +then he proposes a “model,” a simplified version of the object he is +studying that captures its essential features. In physics, the model is +described by a series of parameters (e.g., temperature, energy, time). +Then the physicist uses the model to predict its future evolution by +simulating its motions. In fact, some of the world’s largest +supercomputers are used to simulate the evolution of models, which can +describe protons, nuclear explosions, weather patterns, the big bang, and +the center of black holes. Then you create a better model, using more +sophisticated parameters, and simulate it in time as well." +"For example, when Isaac Newton was puzzling over the motion of the +moon, he created a simple model that would eventually change the +course of human history: he envisioned throwing an apple in the air. The +faster you threw the apple, he reasoned, the farther it would travel. If +you threw it fast enough, in fact, it would encircle the Earth entirely, +and might even return to its original point. Then, Newton claimed, this +model represented the path of the moon, so the forces that guided the +motion of the apple circling the Earth were identical to the forces +guiding the moon." +"But the model, by itself, was still useless. The key breakthrough came +when Newton was able to use his new theory to simulate the future, to +calculate the future position of moving objects. This was a difficult +problem, requiring him to create an entirely new branch of mathematics, +called calculus. Using this new mathematics, Newton was then able to +predict the trajectory of not just the moon, but also Halley’s Comet and +the planets. Since then, scientists have used Newton’s laws to simulate +the future path of moving objects, from cannonballs, machines, +automobiles, and rockets to asteroids and meteors, and even stars and +galaxies. + +The success or failure of a model depends on how faithfully it +reproduces the basic parameters of the original. In this case, the basic +parameter was the location of the apple and the moon in space and time. +By allowing this parameter to evolve (i.e., letting time move forward), +Newton unlocked, for the first time in history, the action of moving" +"bodies, which is one of the most important discoveries in science. + +Models are useful, until they are replaced by even more accurate +models described by better parameters. Einstein replaced Newton’s + +picture of forces acting on apples and moons with a new model based on +a new parameter, the curvature of space and time. An apple moved not +because the Earth exerted a force on it, but because the fabric of space +and time was stretched by the Earth, so the apple was simply moving +along the surface of a curved space-time. From this, Einstein could then +simulate the future of the entire universe. Now, with computers, we can +run simulations of this model into the future and create gorgeous +pictures presenting the collisions of black holes. + +Let us now incorporate this basic strategy into a new theory of +consciousness. + +DEFINITION OF CONSCIOUSNESS" +"DEFINITION OF CONSCIOUSNESS + +I’ve taken bits and pieces from previous descriptions of consciousness in +the fields of neurology and biology in order to define consciousness as +follows: + +Consciousness is the process of creating a model of the world +using multiple feedback loops in various parameters (e.g., in +temperature, space, time, and in relation to others), in order to +accomplish a goal (e.g., find mates, food, shelter). + +I call this the “space-time theory of consciousness,” because it +emphasizes the idea that animals create a model of the world mainly in +relation to space, and to one another, while humans go beyond and +create a model of the world in relation to time, both forward and +backward." +"For example, the lowest level of consciousness is Level 0, where an +organism is stationary or has limited mobility and creates a model of its +place using feedback loops in a few parameters (e.g., temperature). For +example, the simplest level of consciousness is a thermostat. It +automatically turns on an air conditioner or heater to adjust the +temperature in a room, without any help. The key is a feedback loop +that turns on a switch if the temperature gets too hot or cold. (For +example, metals expand when heated, so a thermostat can turn on a +switch if a metal strip expands beyond a certain point.) + + Each feedback loop registers “one unit of consciousness,” so a +thermostat would have a single unit of Level 0 consciousness, that is, +Level 0:1." +"In this way, we can rank consciousness numerically, on the basis of +the number and complexity of the feedback loops used to create a model +of the world. Consciousness is then no longer a vague collection of +undefined, circular concepts, but a system of hierarchies that can be +ranked numerically. For example, a bacterium or a flower has many +more feedback loops, so they would have a higher level of Level 0 +consciousness. A flower with ten feedback loops (which measure +temperature, moisture, sunlight, gravity, etc.), would have a Level 0:10 +consciousness." +"Organisms that are mobile and have a central nervous system have +Level I consciousness, which includes a new set of parameters to +measure their changing location. One example of Level I consciousness +would be reptiles. They have so many feedback loops that they +developed a central nervous system to handle them. The reptilian brain +would have perhaps one hundred or more feedback loops (governing +their sense of smell, balance, touch, sound, sight, blood pressure, etc., +and each of these contains more feedback loops). For example, eyesight +alone involves a large number of feedback loops, since the eye can +recognize color, movement, shapes, light intensity, and shadows. +Similarly, the reptile’s other senses, such as hearing and taste, require +additional feedback loops. The totality of these numerous feedback loops +creates a mental picture of where the reptile is located in the world, and +where other animals (e.g., prey) are located as well. Level I" +"where other animals (e.g., prey) are located as well. Level I +consciousness, in turn, is governed mainly by the reptilian brain, located +in the back and center of the human head." +"Next we have Level II consciousness, where organisms create a model +of their place not only in space but also with respect to others (i.e., they +are social animals with emotions). The number of feedback loops for +Level II consciousness explodes exponentially, so it is useful to introduce +a new numerical ranking for this type of consciousness. Forming allies, +detecting enemies, serving the alpha male, etc., are all very complex +behaviors requiring a vastly expanded brain, so Level II consciousness +coincides with the formation of new structures of the brain in the form +of the limbic system. As noted earlier, the limbic system includes the + +hippocampus (for memories), amygdala (for emotions), and the +thalamus (for sensory information), all of which provide new parameters +for creating models in relation to others. The number and type of +feedback loops therefore change." +"We define the degree of Level II consciousness as the total number of +distinct feedback loops required for an animal to interact socially with +members of its grouping. Unfortunately, studies of animal consciousness +are extremely limited, so little work has been done to catalog all the +ways in which animals communicate socially with one another. But to a +crude first approximation, we can estimate Level II consciousness by +counting the number of fellow animals in its pack or tribe and then +listing the total number of ways in which the animal interacts +emotionally with each one. This would include recognizing rivals and +friends, forming bonds with others, reciprocating favors, building +coalitions, understanding your status and the social ranking of others, +respecting the status of your superiors, displaying your power over your +inferiors, plotting to rise on the social ladder, etc. (We exclude insects +from Level II, because although they have social relations with members" +"from Level II, because although they have social relations with members +of their hive or group, they have no emotions as far as we can tell.)" +"Despite the lack of empirical studies of animal behaviors, we can give +a very rough numerical rank to Level II consciousness by listing the total +number of distinct emotions and social behaviors that the animal can +exhibit. For example, if a wolf pack consists of ten wolves, and each wolf +interacts with all the others with fifteen different emotions and gestures, +then its level of consciousness, to a first approximation, is given by the +product of the two, or 150, so it would have Level 11:150 consciousness. +This number takes into account both the number of other animals it has +to interact with as well as the number of ways it can communicate with +each one. This number only approximates the total number of social +interactions that the animal can display, and will undoubtedly change as +we learn more about its behavior." +"(Of course, because evolution is never clean and precise, there are +caveats that we have to explain, such as the level of consciousness of +social animals that are solitary hunters. We will do so in the notes.) + +LEVEL III CONSCIOUSNESS: SIMULATING THE FUTURE + +With this framework for consciousness, we see that humans are not +unique, and that there is a continuum of consciousness. As Charles +Darwin once commented, “The difference between man and the higher +animals, great as it is, is certainly one of degree and not of kind.” But +what separates human consciousness from the consciousness of animals? +Humans are alone in the animal kingdom in understanding the concept +of tomorrow. Unlike animals, we constantly ask ourselves “What if?” +weeks, months, and even years into the future, so I believe that Level III +consciousness creates a model of its place in the world and then +simulates it into the future, by making rough predictions. We can +summarize this as follows:" +"Human consciousness is a specific form of consciousness that +creates a model of the world and then simulates it in time, by +evaluating the past to simulate the future. This requires +mediating and evaluating many feedback loops in order to +make a decision to achieve a goal. + +By the time we reach Level III consciousness, there are so many +feedback loops that we need a CEO to sift through them in order to +simulate the future and make a final decision. Accordingly, our brains +differ from those of other animals, especially in the expanded prefrontal +cortex, located just behind the forehead, which allows us to “see” into +the future." +"Dr. Daniel Gilbert, a Harvard psychologist, has written, “The greatest +achievement of the human brain is its ability to imagine objects and +episodes that do not exist in the realm of the real, and it is this ability +that allows us to think about the future. As one philosopher noted, the +human brain is an ‘anticipation machine,’ and ‘making the future’ is the +most important thing it does.” + +Using brain scans, we can even propose a candidate for the precise +area of the brain where simulation of the future takes place. Neurologist +Michael Gazzaniga notes that “area 10 (the internal granular layer IV), +in the lateral prefrontal cortex, is almost twice as large in humans as in +apes. Area 10 is involved with memory and planning, cognitive +flexibility, abstract thinking, initiating appropriate behavior, and +inhibiting inappropriate behavior, learning rules, and picking out" +"relevant information from what is perceived through the senses.” (For +this book, we will refer to this area, in which decision making is +concentrated, as the dorsolateral prefrontal cortex, although there is +some overlap with other areas of the brain.) + +Although animals may have a well-defined understanding of their +place in space and some have a degree of awareness of others, it is not +clear if they systematically plan for the future and have an +understanding of “tomorrow.” Most animals, even social animals with +well-developed limbic systems, react to situations (e.g., the presence of +predators or potential mates) by relying mainly on instinct, rather than +systematically planning into the future." +"For instance, mammals do not plan for the winter by preparing to +hibernate, but largely follow instinct as the temperature drops. There is +a feedback loop that regulates their hibernation. Their consciousness is +dominated by messages coming in from their senses. There is no +evidence that they systemically sift through various plans and schemes + + as they prepare to hibernate. Predators, when they use cunning and +disguise to stalk an unsuspecting prey, do anticipate future events, but +this planning is limited only to instinct and the duration of the hunt. +Primates are adept at devising short-term plans (e.g., finding food), but +there is no indication that they plan more than a few hours ahead." +"Humans are different. Although we do rely on instinct and emotions in +many situations, we also constantly analyze and evaluate information +from many feedback loops. We do this by running simulations sometimes +even beyond our own life span and even thousands of years into the +future. The point of running simulations is to evaluate various +possibilities to make the best decision to fulfill a goal. This occurs in the +prefrontal cortex, which allows us to simulate the future and evaluate +the possibilities in order to chart the best course of action. + +This ability evolved for several reasons. First, having the ability to +peer into the future has enormous evolutionary benefits, such as evading +predators and finding food and mates. Second, it allows us to choose +among several different outcomes and to select the best one." +"Third, the number of feedback loops explodes exponentially as we go +from Level 0 to Level I to Level II, so we need a “CEO” to evaluate all +these conflicting, competing messages. Instinct is no longer enough. +There has to be a central body that evaluates each of these feedback + +loops. This distinguishes human consciousness from that of the animals. +These feedback loops are evaluated, in turn, by simulating them into the +future to obtain the best outcome. If we didn’t have a CEO, chaos would +ensue and we would have sensory overload. + +A simple experiment can demonstrate this. David Eagleman describes +how you can take a male stickleback fish and have a female fish trespass +on its territory. The male gets confused, because it wants to mate with +the female, but it also wants to defend its territory. As a result, the male +stickleback fish will simultaneously attack the female while initiating +courtship behavior. The male is driven into a frenzy, trying to woo and +kill the female at the same time." +"This works for mice as well. Put an electrode in front of a piece of +cheese. If the mouse gets too close, the electrode will shock it. One +feedback loop tells the mouse to eat the cheese, but another one tells the +mouse to stay away and avoid being shocked. By adjusting the location +of the electrode, you can get the mouse to oscillate, torn between two +conflicting feedback loops. While a human has a CEO in its brain to +evaluate the pros and cons of the situation, the mouse, governed by two +conflicting feedback loops, goes back and forth. (This is like the proverb +about the donkey that starves to death because it is placed between two + + equal bales of hay.)" +"equal bales of hay.) + +Precisely how does the brain simulate the future? The human brain is +flooded by a large amount of sensory and emotional data. But the key is +to simulate the future by making causal links between events—that is, if +A happens, then B happens. But if B happens, then C and D might result. +This sets off a chain reaction of events, eventually creating a tree of +possible cascading futures with many branches. The CEO in the +prefrontal cortex evaluates the results of these causal trees in order to +make the ultimate decision. + +Let’s say you want to rob a bank. How many realistic simulations of +this event can you make? To do this, you have to think of the various +causal links involving the police, bystanders, alarm systems, relations +with fellow criminals, traffic conditions, the DA’s office, etc. For a +successful simulation of the robbery, hundreds of causal links may have +to be evaluated." +"It is also possible to measure this level of consciousness numerically. +Let’s say that a person is given a series of different situations like the one + +above and is asked to simulate the future of each. The sum total number +of causal links that the person can make for all these situations can be +tabulated. (One complication is that there are an unlimited number of +causal links that a person might make for a variety of conceivable +situations. To get around this complication, we divide this number by +the average number of causal links obtained from a large control group. +Like the IQ exam, one may multiply this number by 100. So a person’s +level of consciousness, for example, might be Level 111:100, meaning that +the person can simulate future events just like the average person.) + +We summarize these levels of consciousness in the following diagram: + +LEVELS OF CONSCIOUSNESS FOR DIFFERENT SPECIES + +LEVEL + +SPECIES + +PARAMETER + +BRAIN STRUCTURE + +0 + +| Plants + + | Temperature, sunshine + +None + +1" +"SPECIES + +PARAMETER + +BRAIN STRUCTURE + +0 + +| Plants + + | Temperature, sunshine + +None + +1 + +Reptiles + +j Space + +Brain stem + +II + +| Mammals + +| Social relations + +j Limbic system + +III + +j Humans + +| Time (esp. future) + +j Prefrontal cortex + +Space-time theory of consciousness. We define consciousness as the process of creating a model of the +world using +multiple feedback loops in various parameters (e.g., in space, time, and in relation to others), in order to +accomplish a +goal. Human consciousness is a particular type that involves mediating between these feedback loops +by simulating the + +future and evaluating the past." +"future and evaluating the past. + +(Notice that these categories correspond to the rough evolutionary +levels we find in nature—e.g., reptiles, mammals, and humans. However, +there are also gray areas, such as animals that might possess tiny aspects +of different levels of consciousness, animals that do some rudimentary +planning, or even single cells that communicate with one another. This +chart is meant only to give you the larger, global picture of how +consciousness is organized across the animal kingdom.) + +WHAT IS HUMOR? WHY DO WE HAVE EMOTIONS? + + All theories have to be falsifiable. The challenge for the space-time +theory of consciousness is to explain all aspects of human consciousness" +"in this framework. It can be falsified if there are patterns of thought that +cannot be brought into this theory. A critic might say that surely our +sense of humor is so quixotic and ephemeral that it is beyond +explanation. We spend a great deal of time laughing with our friends or +at comedians, yet it seems that humor has nothing to do with our +simulations of the future. But consider this. Much of humor, such as +telling a joke, depends on the punch line." +"When hearing a joke, we can’t help but simulate the future and +complete the story ourselves (even if we’re unaware that we’re doing +so). We know enough about the physical and social world that we can +anticipate the ending, so we burst out with laughter when the punch line +gives us a totally unexpected conclusion. The essence of humor is when +our simulation of the future is suddenly disrupted in surprising ways. +(This was historically important for our evolution since success depends, +in part, on our ability to simulate future events. Since life in the jungle is +full of unanticipated events, anyone who can foresee unexpected +outcomes has a better chance at survival. In this way, having a well- +developed sense of humor is actually one indication of our Level III +consciousness and intelligence; that is, the ability to simulate the future.)" +"For example, W. C. Fields was once asked a question about social +activities for youth. He was asked, “Do you believe in clubs for young +people?” He replied, “Only when kindness fails.” + +The joke has a punch line only because we mentally simulate a future +in which children have social clubs, while W. C. Fields simulates a +different future involving clubs as a weapon. (Of course, if a joke is +deconstructed, it loses its power, since we have already simulated +various possible futures in our minds.) + +This also explains what every comedian knows: timing is the key to +humor. If the punch line is delivered too quickly, then the brain hasn’t +had time to simulate the future, so there is no experience of the +unanticipated. If the punch line is delivered too late, the brain has +already had time to simulate various possible futures, so again the punch +line loses the element of surprise." +"(Humor has other functions, of course, such as bonding with fellow +members of our tribe. In fact, we use our sense of humor as a way to size +up the character of others. This, in turn, is essential to determine our +status within society. So in addition, laughter helps define our position + + in the social world, i.e., Level II consciousness.) + +WHY DO WE GOSSIP AND PLAY? + +Even seemingly trivial activities, such as engaging in idle gossip or +horsing around with our friends, must be explained in this framework. +(If a Martian were to visit a supermarket checkout line and view the +huge display of gossip magazines, it might conclude that gossip is the +main activity of humans. This observation would not be far off.)" +"Gossiping is essential for survival because the complex mechanics of +social interactions are constantly changing, so we have to make sense of +this ever-shifting social terrain. This is Level II consciousness at work. +But once we hear a piece of gossip, we immediately run simulations to +determine how this will affect our own standing in the community, +which moves us to Level III consciousness. Thousands of years ago, in +fact, gossip was the only way to obtain vital information about the tribe. +One’s very life often depended on knowing the latest gossip." +"Something as superfluous as “play” is also an essential feature of +consciousness. If you ask children why they like to play, they will say, +“Because it’s fun.” But that invites the next question: What is fun? +Actually, when children play, they are often trying to reenact complex +human interactions in simplified form. Human society is extremely +sophisticated, much too involved for the developing brains of young +children, so children run simplified simulations of adult society, playing +games such as doctor, cops and robber, and school. Each game is a +model that allows children to experiment with a small segment of adult +behavior and then run simulations into the future. (Similarly, when +adults engage in play, such as a game of poker, the brain constantly +creates a model of what cards the various players possess, and then +projects that model into the future, using previous data about people’s +personality, ability to bluff, etc. The key to games like chess, cards, and" +"personality, ability to bluff, etc. The key to games like chess, cards, and +gambling is the ability to simulate the future. Animals, which live +largely in the present, are not as good at games as humans are, +especially if they involve planning. Infant mammals do engage in a form +of play, but this is more for exercise, testing one another, practicing +future battles, and establishing the coming social pecking order rather" +"than simulating the future.) + +My space-time theory of consciousness might also shed light on + + another controversial topic: intelligence. Although IQ exams claim to +measure “intelligence,” IQ exams actually give no definition of +intelligence in the first place. In fact, a cynic may claim, with some +justification, that IQ is a measure of “how well you do on IQ exams,” +which is circular. In addition, IQ exams have been criticized for being +too culturally biased. In this new framework, however, intelligence may +be viewed as the complexity of our simulations of the future. Hence, a +master criminal, who may be a dropout and functionally illiterate and +score dismally low on an IQ exam, may also far outstrip the ability of the +police. Outwitting the cops may entail simply being able to run more +sophisticated simulations of the future. + +LEVEL I: STREAM OF CONSCIOUSNESS" +"LEVEL I: STREAM OF CONSCIOUSNESS + +Humans are probably alone on this planet in being able to operate on all +levels of consciousness. Using MRI scans, we can break down the +different structures involved in each level of consciousness." +"For us, Level I stream of consciousness is largely the interplay between +the prefrontal cortex and the thalamus. When taking a leisurely stroll in +the park, we are aware of the smells of the plants, the sensation of a +gentle breeze, the visual stimuli from the sun, and so on. Our senses send +signals to the spinal cord, the brain stem, and then to the thalamus, +which operates like a relay station, sorting out the stimuli and sending +them on to the various cortices of the brain. The images of the park, for +example, are sent to the occipital cortex in the back of the brain, while +the sense of touch from the wind is sent to the parietal lobe. The signals +are processed in appropriate cortices, and then sent to the prefrontal +cortex, where we finally become conscious of all these sensations. + +This is illustrated in Figure 7. + +LEVEL II: FINDING OUR PLACE IN SOCIETY" +"This is illustrated in Figure 7. + +LEVEL II: FINDING OUR PLACE IN SOCIETY + +While Level I consciousness uses sensations to create a model of our +physical location in space, Level II consciousness creates a model of our + +place in society. + +Let’s say we are going to an important cocktail party, in which people +essential to our job will be present. As we scan the room, trying to +identify people from our workplace, there is an intense interplay +between the hippocampus (which processes memories), the amygdala +(which processes emotions), and the prefrontal cortex (which puts all + + this information together). + +Figure 7. In Level I consciousness, sensory information travels through the brain stem, past the +thalamus, onto the various +cortices of the brain, and finally to the prefrontal cortex. Thus this stream of Level I consciousness is +created by the flow +of information from the thalamus to the prefrontal cortex, (illustration credit 2.1)" +"With each image, the brain automatically attaches an emotion, such as +happiness, fear, anger, or jealousy, and processes the emotion in the + +amygdala. + +If you spot your chief rival, whom you suspect of stabbing you in the +back, the emotion of fear is processed by the amygdala, which sends an +urgent message to the prefrontal cortex, alerting it to possible danger. At +the same time, signals are sent to your endocrine system to start +pumping adrenaline and other hormones into the blood, thereby +increasing your heartbeat and preparing you for a possible fight-or-flight +response. + +This is illustrated in Figure 8." +"This is illustrated in Figure 8. + +But beyond simply recognizing other people, the brain has the +uncanny ability to guess what other people are thinking about. This is +called the Theory of Mind, a theory first proposed by Dr. David Premack +of the University of Pennsylvania, which is the ability to infer the +thoughts of others. In any complex society, anyone with the ability to +correctly guess the intentions, motives, and plans of other people has a +tremendous survival advantage over those who can’t. The Theory of +Mind allows you to form alliances with others, isolate your enemies, and +solidify your friendships, which vastly increases your power and chances +of survival and mating. Some anthropologists even believe that the +mastery of the Theory of Mind was essential in the evolution of the +brain." +"Figure 8. Emotions originate and are processed in the limbic system. In Level II consciousness, we are +continually +bombarded with sensory information, but emotions are rapid-fire responses to emergencies from the +limbic system that + + do not need permission from the prefrontal cortex. The hippocampus is also important for processing +memories. So Level +II consciousness, at its core, involves the reaction of the amygdala, hippocampus, and prefrontal cortex, +(illustration + +credit 2.2) + +But how is the Theory of Mind accomplished? One clue came in 1996, +with the discovery of “mirror neurons” by Drs. Giacomo Rizzolatti, +Leonardo Fogassi, and Vittorio Gallese. These neurons fire when you are +performing a certain task and also when you see someone else +performing that same task. (Mirror neurons also fire for emotions as well +as physical acts. If you feel a certain emotion, and think another is +feeling that same emotion, then the mirror neurons will fire.)" +"Mirror neurons are essential for mimicry and also for empathy, giving + +us the ability not only to copy the complex tasks performed by others +but also to experience the emotions that person must be feeling. Mirror +neurons were thus probably essential for our evolution as human beings, +since cooperation is essential for holding the tribe together." +"Mirror neurons were first found in the premotor areas of monkey +brains. But since then, they have been found in humans in the prefrontal +cortex. Dr. V. S. Ramachandran believes that mirror neurons were +essential in giving us the power of self-awareness and concludes, “I +predict that mirror neurons will do for psychology what DNA did for +biology: they will provide a unifying framework and help explain a host +of mental abilities that have hitherto remained mysterious and +inaccessible to experiments.” (We should point out, however, that all +scientific results have to be tested and reconfirmed. There is no doubt +that certain neurons are performing this crucial behavior involved with +empathy, mimicry, etc., but there is some debate about the identity of +these mirror neurons. For example, some critics claim that perhaps these +behaviors are common to many neurons, and that there is not a single +class of neurons dedicated to this behavior.) + +LEVEL III: SIMULATING THE FUTURE" +"LEVEL III: SIMULATING THE FUTURE + +The highest level of consciousness, which is associated primarily with +Homo sapiens, is Level III consciousness, in which we take our model of +the world and then run simulations into the future. We do this by +analyzing past memories of people and events, and then simulating the + + future by making many causal links to form a “causal” tree. As we look +at the various faces at the cocktail party, we begin to ask ourselves +simple questions: How can this individual help me? How will the gossip +floating in the room play out in the future? Is anyone out to get me? + +Let’s say that you just lost your job and you are desperately looking +for a new one. In this case, as you talk to various people at the cocktail +party, your mind is feverishly simulating the future with each person +you talk to. You ask yourself, How can I impress this person? What +topics should I bring out to present my best case? Can he offer me a job?" +"Figure 9. Simulating the future, the heart of Level III consciousness, is mediated by the dorsolateral +prefrontal cortex, the +CEO of the brain, with competition between the pleasure center and the orbitofrontal cortex (which acts +to check our +impulses). This roughly resembles the outline given by Freud of the struggle between our conscience +and desires. The +actual process of simulating the future takes place when the prefrontal cortex accesses the memories of +the past in order + +to approximate future events, (illustration credit 2.3)" +"to approximate future events, (illustration credit 2.3) + +Recent brain scans have shed partial light on how the brain simulates +the future. These simulations are done mainly in the dorsolateral +prefrontal cortex, the CEO of the brain, using memories of the past. On +one hand, simulations of the future may produce outcomes that are +desirable and pleasurable, in which case the pleasure centers of the brain +light up (in the nucleus accumbens and hypothalamus). On the other +hand, these outcomes may also have a downside to them, so the +orbitofrontal cortex kicks in to warn us of possible dangers. There is a + +struggle, then, between different parts of the brain concerning the +future, which may have desirable and undesirable outcomes. Ultimately +it is the dorsolateral prefrontal cortex that mediates between these and +makes the final decisions. (See Figure 9.) (Some neurologists have +pointed out that this struggle resembles, in a crude way, the dynamics +between Freud’s ego, id, and superego.)" +"THE MYSTERY OF SELF-AWARENESS + + If the space-time theory of consciousness is correct, then it also gives us +a rigorous definition of self-awareness. Instead of vague, circular +references, we should be able to give a definition that is testable and +useful. We’ll define self-awareness as follows: + +Self-awareness is creating a model of the world and simulating + +the future in which you appear. + +Animals therefore have some self-awareness, since they have to know +where they are located if they are going to survive and mate, but it is +limited largely by instinct. + +When most animals are placed in front of a mirror, they either ignore +it or attack it, not realizing that it is an image of themselves. (This is +called the “mirror test,” which goes all the way back to Darwin.) +However, animals like elephants, the great apes, bottlenose dolphins, +orcas, and European magpies can figure out that the image they see in +the mirror represents themselves." +"Humans, however, take a giant step forward and constantly run future +simulations in which we appear as a principal actor. We constantly +imagine ourselves faced with different situations—going on a date, +applying for a job, changing careers—none of which is determined by +instinct. It is extremely difficult to stop your brain from simulating the +future, though elaborate methods have been devised (for instance, +meditation) to attempt to do so. + +Daydreaming, as an example, consists largely of our acting out +different possible futures to attain a goal. Since we pride ourselves in +knowing our limitations and strengths, it is not hard to put ourselves + +inside the model and hit the “play” button so we begin to act out +hypothetical scenarios, like being an actor in a virtual play. + +WHERE AM “I”?" +"WHERE AM “I”? + +There is probably a specific part of the brain whose job it is to unify the +signals from the two hemispheres to create a smooth, coherent sense of +self. Dr. Todd Heatherton, a psychologist at Dartmouth College, believes +that this region is located within the prefrontal cortex, in what is called +the medial prefrontal cortex. Biologist Dr. Carl Zimmer writes, “The +medial prefrontal cortex may play the same role for the self as the +hippocampus plays in memory ... [it] could be continually stitching +together a sense of who we are.” In other words, this may be the +gateway to the concept of “I,” the central region of the brain that fuses, + + integrates, and concocts a unified narrative of who we are. (This does +not mean, however, that the medial prefrontal cortext is the homunculus +sitting in our brain that controls everything.)" +"If this theory is true, then the resting brain, when we are idly +daydreaming about our friends and ourselves, should be more active +than normal, even when other parts of the brain’s sensory regions are +quiet. In fact, brain scans bear this out. Dr. Heatherton concludes, “Most +of the time we daydream—we think about something that happened to +us or what we think about other people. All this involves self-reflection.” + +The space-time theory says that consciousness is cobbled together +from many subunits of the brain, each competing with the others to +create a model of the world, and yet our consciousness feels smooth and +continuous. How can this be, when we all have the feeling that our “self” +is uninterrupted and always in charge?" +"In the previous chapter, we met the plight of split-brain patients, who +sometimes struggle with alien hands that literally have a mind of their +own. It does appear that there are two centers of consciousness living +within the same brain. So how does all this create the sense that we have +a unified, cohesive “self’ existing within our brains? + +I asked one person who may have the answer: Dr. Michael Gazzaniga, +who has spent several decades studying the strange behavior of split- +brain patients. He noticed that the left brain of split-brain patients, when" +"confronted with the fact that there seem to be two separate centers of +consciousness residing in the same skull, would simply make up strange +explanations, no matter how silly. He told me that, when presented with +an obvious paradox, the left brain will “confabulate” an answer to +explain inconvenient facts. Dr. Gazzaniga believes that this gives us the +false sense that we are unified and whole. He calls the left brain the +“interpreter,” which is constantly thinking up ideas to paper over +inconsistencies and gaps in our consciousness." +"For example, in one experiment, he flashed the word “red” to just the +left brain of a patient, and the word “banana” to just the right brain. +(Notice that the dominant left brain therefore does not know about the +banana.) Then the subject was asked to pick up a pen with his left hand +(which is governed by the right brain) and draw a picture. Naturally he +drew a picture of a banana. Remember that the right brain could do this, +because it had seen the banana, but the left brain had no clue that the +banana had been flashed to the right brain. + +Then he was asked why he had drawn the banana. Because only the +left brain controls speech, and because the left brain did not know" +"anything about a banana, the patient should have said, “I don’t know.” +Instead he said, “It is easiest to draw with this hand because this hand +can pull down easier.” Dr. Gazzaniga noted that the left brain was trying +to find some excuse for this inconvenient fact, even though the patient +was clueless about why his right hand drew the banana. + +Dr. Gazzaniga concludes, “It is the left hemisphere that engages in the +human tendency to find order in chaos, that tries to fit everything into a +story and put it into a context. It seems that it is driven to hypothesize +about the structure of the world even in the face of evidence that no +pattern exists.”" +"This is where our sense of a unified “self’ comes from. Although +consciousness is a patchwork of competing and often contradictory +tendencies, the left brain ignores inconsistencies and papers over +obvious gaps in order to give us a smooth sense of a single “I.” In other +words, the left brain is constantly making excuses, some of them +harebrained and preposterous, to make sense of the world. It is +constantly asking “Why?” and dreaming up excuses even if the question +has no answer. + +(There is probably an evolutionary reason that we evolved our split" +"(There is probably an evolutionary reason that we evolved our split + +brains. A seasoned CEO will often encourage his aides to take opposing +sides of an issue, to encourage thorough and thoughtful debate. +Oftentimes, the correct view emerges out of intense interaction with +incorrect ideas. Similarly, the two halves of the brain complement each +other, offering pessimistic/optimistic or analytical/holistic analysis of +the same idea. The two halves of the brain therefore play off each other. +Indeed, as we shall see, certain forms of mental illness may arise when +this interplay between the two brains goes awry.)" +"Now that we have a working theory of consciousness, the time has come +to utilize it to understand how neuroscience will evolve in the future. +There is a vast and remarkable set of experiments now being done in +neuroscience that are fundamentally altering the entire scientific +landscape. Using the power of electromagnetism, scientists can now +probe people’s thoughts, send telepathic messages, telekinetically control +objects around us, record memories, and perhaps enhance our +intelligence. + +Perhaps the most immediate and practical application of this new +technology is something once considered to be hopelessly impossible: +telepathy. + + BOOK II MIND OVER MATTER + +The brain, like it or not, is a machine. Scientists have come to +that conclusion, not because they are mechanistic killjoys, but +because they have amassed evidence that every aspect of +consciousness can be tied to the brain. + +—STEVEN PINKER + +3 TELEPATHY A PENNY FOR YOUR THOUGHTS" +"—STEVEN PINKER + +3 TELEPATHY A PENNY FOR YOUR THOUGHTS + +Harry Houdini, some historians believe, was the greatest magician +who ever lived. His breathtaking escapes from locked, sealed chambers +and death-defying stunts left audiences gasping. He could make people +disappear and then reemerge in the most unexpected places. And he +could read people’s minds. + +Or at least it seemed that way. + +Houdini took pains to explain that everything he did was an illusion, a +series of clever sleight-of-hand tricks. Mind reading, he would remind +people, was impossible. He was so outraged that unscrupulous magicians +would cheat wealthy patrons by performing cheap parlor tricks and +seances that he even went around the country exposing fakes by +pledging he could duplicate any feat of mind reading performed by these +charlatans. He was even on a committee organized by Scientific American +that offered a generous reward to anyone who could positively prove +they had psychic power. (No one ever picked up the reward.)" +"Houdini believed that telepathy was impossible. But science is proving +Houdini wrong. + +Telepathy is now the subject of intense research at universities around +the world, where scientists have already been able to use advanced +sensors to read individual words, images, and thoughts in a person’s +brain. This could alter the way we communicate with stroke and +accident victims who are “locked in” their bodies, unable to articulate +their thoughts except through blinks. But that’s just the start. Telepathy +might also radically change the way we interact with computers and the +outside world. + +Indeed, in a recent “Next 5 in 5 Forecast,” which predicts five +revolutionary developments in the next five years, IBM scientists claimed +that we will be able to mentally communicate with computers, perhaps + + replacing the mouse and voice commands. This means using the power +of the mind to call people on the phone, pay credit card bills, drive cars," +"make appointments, create beautiful symphonies and works of art, etc. +The possibilities are endless, and it seems that everyone—from computer +giants, educators, video game companies, and music studios to the +Pentagon—is converging on this technology." +"True telepathy, found in science-fiction and fantasy novels, is not +possible without outside assistance. As we know, the brain is electrical. +In general, anytime an electron is accelerated, it gives off +electromagnetic radiation. The same holds true for electrons oscillating +inside the brain, which broadcasts radio waves. But these signals are too +faint to be detected by others, and even if we could perceive these radio +waves, it would be difficult to make sense of them. Evolution has not +given us the ability to decipher this collection of random radio signals, +but computers can. Scientists have been able to get crude +approximations of a person’s thoughts using EEG scans. Subjects would +put on a helmet with EEG sensors and concentrate on certain pictures— +say, the image of a car. The EEG signals were then recorded for each +image and eventually a rudimentary dictionary of thought was created, +with a one-to-one correspondence between a person’s thoughts and the" +"with a one-to-one correspondence between a person’s thoughts and the +EEG image. Then, when a person was shown a picture of another car, +the computer would recognize the EEG pattern as being from a car." +"The advantage of EEG sensors is that they are noninvasive and quick. +You simply put a helmet containing many electrodes onto the surface of +the brain and the EEG can rapidly identify signals that change every +millisecond. But the problem with EEG sensors, as we have seen, is that +electromagnetic waves deteriorate as they pass through the skull, and it +is difficult to locate their precise source. This method can tell if you are +thinking of a car or a house, but it cannot re-create an image of the car. +That is where Dr. Jack Gallant’s work comes in. + +VIDEOS OF THE MIND + +The epicenter for much of this research is the University of California at +Berkeley, where I received my own Ph.D. in theoretical physics years +ago. I had the pleasure of touring the laboratory of Dr. Gallant, whose +group has accomplished a feat once considered to be impossible: +videotaping people’s thoughts. “This is a major leap forward + +reconstructing internal imagery. We are opening a window into the" +"reconstructing internal imagery. We are opening a window into the + + movies in our mind,” says Gallant. + +When I visited his laboratory, the first thing I noticed was the team of +young, eager postdoctoral and graduate students huddled in front of +their computer screens, looking intently at video images that were +reconstructed from someone’s brain scan. Talking to Gallant’s team, you +feel as though you are witnessing scientific history in the making." +"Gallant explained to me that first the subject lies flat on a stretcher, +which is slowly inserted headfirst into a huge, state-of-the-art MRI +machine, costing upward of $3 million. The subject is then shown +several movie clips (such as movie trailers readily available on +YouTube). To accumulate enough data, the subject has to sit motionless +for hours watching these clips, a truly arduous task. I asked one of the +postdocs, Dr. Shinji Nishimoto, how they found volunteers who were +willing to lie still for hours on end with only fragments of video footage +to occupy the time. He said the people in the room, the grad students +and postdocs, volunteered to be guinea pigs for their own research." +"As the subject watches the movies, the MRI machine creates a 3-D +image of the blood flow within the brain. The MRI image looks like a +vast collection of thirty thousand dots, or voxels. Each voxel represents a +pinpoint of neural energy, and the color of the dot corresponds to the +intensity of the signal and blood flow. Red dots represent points of large +neural activity, while blue dots represent points of less activity. (The +final image looks very much like thousands of Christmas lights in the +shape of the brain. Immediately you can see that the brain is +concentrating most of its mental energy in the visual cortex, which is +located at the back of the brain, while watching these videos.)" +"Gallant’s MRI machine is so powerful it can identify two to three +hundred distinct regions of the brain and, on average, can take snapshots +that have one hundred dots per region of the brain. (One goal for future +generations of MRI technology is to provide an even sharper resolution +by increasing the number of dots per region of the brain.) + +At first, this 3-D collection of colored dots looks like gibberish. But +after years of research, Dr. Gallant and his colleagues have developed a +mathematical formula that begins to find relationships between certain +features of a picture (edges, textures, intensity, etc.) and the MRI voxels. +For example, if you look at a boundary, you’ll notice it’s a region" +"separating lighter and darker areas, and hence the edge generates a +certain pattern of voxels. By having subject after subject view such a +large library of movie clips, this mathematical formula is refined, +allowing the computer to analyze how all sorts of images are converted +into MRI voxels. Eventually the scientists were able to ascertain a direct + + correlation between certain MRI patterns of voxels and features within +each picture." +"correlation between certain MRI patterns of voxels and features within +each picture. + +At this point, the subject is then shown another movie trailer. The +computer analyzes the voxels generated during this viewing and re¬ +creates a rough approximation of the original image. (The computer +selects images from one hundred movie clips that most closely resemble +the one that the subject just saw and then merges images to create a +close approximation.) In this way, the computer is able to create a fuzzy +video of the visual imagery going through your mind. Dr. Gallant’s +mathematical formula is so versatile that it can take a collection of MRI +voxels and convert it into a picture, or it can do the reverse, taking a +picture and then converting it to MRI voxels." +"I had a chance to view the video created by Dr. Gallant’s group, and it +was very impressive. Watching it was like viewing a movie with faces, +animals, street scenes, and buildings through dark glasses. Although you +could not see the details within each face or animal, you could clearly +identify the kind of object you were seeing." +"Not only can this program decode what you are looking at, it can also +decode imaginary images circulating in your head. Let’s say you are +asked to think of the Mona Lisa. We know from MRI scans that even +though you’re not viewing the painting with your eyes, the visual cortex +of your brain will light up. Dr. Gallant’s program then scans your brain +while you are thinking of the Mona Lisa and flips through its data files of +pictures, trying to find the closest match. In one experiment I saw, the +computer selected a picture of the actress Salma Hayek as the closest +approximation to the Mona Lisa. Of course, the average person can easily +recognize hundreds of faces, but the fact that the computer analyzed an +image within a person’s brain and then picked out this picture from +millions of random pictures at its disposal is still impressive." +"The goal of this whole process is to create an accurate dictionary that +allows you to rapidly match an object in the real world with the MRI +pattern in your brain. In general, a detailed match is very difficult and + +will take years, but some categories are actually easy to read just by +flipping through some photographs. Dr. Stanislas Dehaene of the College +de France in Paris was examining MRI scans of the parietal lobe, where +numbers are recognized, when one of his postdocs casually mentioned +that just by quickly scanning the MRI pattern, he could tell what number +the subject was looking at. In fact, certain numbers created distinctive +patterns on the MRI scan. He notes, “If you take 200 voxels in this area, +and look at which of them are active and which are inactive, you can +construct a machine-learning device that decodes which number is being +held in memory.”" +"This leaves open the question of when we might be able to have +picture-quality videos of our thoughts. Unfortunately, information is lost +when a person is visualizing an image. Brain scans corroborate this. +When you compare the MRI scan of the brain as it is looking at a flower +to an MRI scan as the brain is thinking about a flower, you immediately +see that the second image has far fewer dots than the first. So although +this technology will vastly improve in the coming years, it will never be +perfect. (I once read a short story in which a man meets a genie who +offers to create anything that the person can imagine. The man +immediately asks for a luxury car, a jet plane, and a million dollars. At +first, the man is ecstatic. But when he looks at these items in detail, he +sees that the car and the plane have no engines, and the image on the +cash is all blurred. Everything is useless. This is because our memories +are only approximations of the real thing.)" +"But given the rapidity with which scientists are beginning to decode +the MRI patterns in the brain, will we soon be able to actually read +words and thoughts circulating in the mind? + +READING THE MIND + +In fact, in a building next to Gallant’s laboratory, Dr. Brian Pasley and +his colleagues are literally reading thoughts—at least in principle. One of +the postdocs there, Dr. Sara Szczepanski, explained to me how they are +able to identify words inside the mind. + +The scientists used what is called ECOG (electrocorticogram) +technology, which is a vast improvement over the jumble of signals that + +EEG scans produce. ECOG scans are unprecedented in accuracy and +resolution, since signals are directly recorded from the brain and do not +pass through the skull. The flipside is that one has to remove a portion +of the skull to place a mesh, containing sixty-four electrodes in an eight- +by-eight grid, directly on top of the exposed brain." +"Luckily they were able to get permission to conduct experiments with +ECOG scans on epileptic patients, who were suffering from debilitating +seizures. The ECOG mesh was placed on the patients’ brains while open- +brain surgery was being performed by doctors at the nearby University +of California at San Francisco. + +As the patients hear various words, signals from their brains pass +through the electrodes and are then recorded. Eventually a dictionary is +formed, matching the word with the signals emanating from the + + electrodes in the brain. Later, when a word is uttered, one can see the +same electrical pattern. This correspondence also means that if one is +thinking of a certain word, the computer can pick up the characteristic +signals and identify it." +"With this technology, it might be possible to have a conversation that +takes place entirely telepathically. Also, stroke victims who are totally +paralyzed may be able to “talk” through a voice synthesizer that +recognizes the brain patterns of individual words. + +Not surprisingly, BMI (brain-machine interface) has become a hot +field, with groups around the country making significant breakthroughs. +Similar results were obtained by scientists at the University of Utah in +2011. They placed grids, each containing sixteen electrodes, over the +facial motor cortex (which controls movements of the mouth, lips, +tongue, and face) and Wernicke’s area, which processes information +about language." +"The person was then asked to say ten common words, such as “yes” +and “no,” “hot” and “cold,” “hungry” and “thirsty,” “hello” and “good¬ +bye,” and “more” and “less.” Using a computer to record the brain +signals when these words were uttered, the scientists were able to create +a rough one-to-one correspondence between spoken words and computer +signals from the brain. Later, when the patient voiced certain words, +they were able to correctly identify each one with an accuracy ranging +from 76 percent to 90 percent. The next step is to use grids with 121 +electrodes to get better resolution. + +In the future, this procedure may prove useful for individuals suffering +from strokes or paralyzing illnesses such as Lou Gehrig’s disease, who +would be able to speak using the brain-to-computer technique. + +TYPING WITH THE MIND" +"TYPING WITH THE MIND + +At the Mayo Clinic in Minnesota, Dr. Jerry Shih has hooked up epileptic +patients via ECOG sensors so they can learn how to type with the mind. +The calibration of this device is simple. The patient is first shown a +series of letters and is told to focus mentally on each symbol. A +computer records the signals emanating from the brain as it scans each +letter. As with the other experiments, once this one-to-one dictionary is +created, it is then a simple matter for the person to merely think of the +letter and for the letter to be typed on a screen, using only the power of +the mind. + +Dr. Shih, the leader of this project, says that the accuracy of his + + machine is nearly 100 percent. Dr. Shih believes that he can next create +a machine to record images, not just words, that patients conceive in +their minds. This could have applications for artists and architects, but +the big drawback of ECOG technology, as we have mentioned, is that it +requires opening up patients’ brains." +"Meanwhile, EEG typewriters, because they are noninvasive, are +entering the marketplace. They are not as accurate or precise as ECOG +typewriters, but they have the advantage that they can be sold over the +counter. Guger Technologies, based in Austria, recently demonstrated an +EEG typewriter at a trade show. According to their officials, it takes only +ten minutes or so for people to learn how to use this machine, and they +can then type at the rate of five to ten words per minute. + +TELEPATHIC DICTATION AND MUSIC + +The next step might be to transmit entire conversations, which could +rapidly speed up telepathic transmission. The problem, however, is that +it would require making a one-to-one map between thousands of words +and their EEG, MRI, or ECOG signals. But if one can, for example, +identify the brain signals of several hundred select words, then one" +"might be able to rapidly transmit words found in a common +conversation. This means that one would think of the words in entire +sentences and paragraphs of a conversation and a computer would print +them out. + +This could be extremely useful for journalists, writers, novelists, and +poets, who could simply think and have a computer take dictation. The +computer would also become a mental secretary. You would mentally +give instructions to the robo-secretary about a dinner, plane trip, or +vacation, and it would fill in all the details about the reservations." +"Not only dictation but also music may one day be transcribed in this +way. Musicians would simply hum a few melodies in their head and a +computer would print them out, in musical notation. To do this, you +would ask someone to mentally hum a series of notes, which would +generate certain electrical signals for each one. A dictionary would again +be created in this way, so that when you think of a musical note, the +computer would print it out in musical notation. + +In science fiction, telepaths often communicate across language +barriers, since thoughts are considered to be universal. However, this +might not be true. Emotions and feelings may well be nonverbal and +universal, so that one could telepathically send them to anyone, but + + rational thinking is so closely tied to language that it is very unlikely +that complex thoughts could be sent across language barriers. Words will +still be sent telepathically in their original language. + +TELEPATHY HELMETS" +"TELEPATHY HELMETS + +In science fiction, we also often encounter telepathy helmets. Put them +on, and—presto!—you can read other people’s minds. The U.S. Army, in +fact, has expressed interest in this technology. In a firefight, with +explosions going off and bullets whizzing overhead, a telepathy helmet +could be a lifesaver, since it can be difficult to communicate orders amid +the sound and fury of the battlefield. (I can personally testify to this. +Years ago, during the Vietnam War, I served in the U.S. Infantry at Fort +Benning, outside Atlanta, Georgia. During machine-gun training, the +sound of hand grenades and rounds of bullets going off on the battlefield +next to my ear was deafening; it was so intense I could not hear anything + +else. Later, there was a loud ringing in my ear that lasted for three full +days.) With a telepathy helmet, a soldier could mentally communicate +with his platoon amid all the thunder and noise." +"Recently, the army gave a $6.3 million grant to Dr. Gerwin Schalk at +Albany Medical College, but it knows that a fully functional telepathy +helmet is still years away. Dr. Schalk experiments with ECOG +technology, which, as we have seen, requires placing a mesh of +electrodes directly on top of the exposed brain. With this method, his +computers have been able to recognize vowels and thirty-six individual +words inside the thinking brain. In some of his experiments, he +approached 100 percent accuracy. But at present, this is still impractical +for the U.S. Army, since it requires removing part of the skull in the +clean, sterile environment of a hospital. And even then, recognizing +vowels and a handful of words is a far cry from sending urgent messages +to headquarters in a firefight. But his ECOG experiments have +demonstrated that it is possible to communicate mentally on the +battlefield." +"Another method is being explored by Dr. David Poeppel of New York +University. Instead of opening up the skulls of his subjects, he employs +MEG technology, using tiny bursts of magnetic energy rather than +electrodes to create electrical charges in the brain. Besides being +noninvasive, the advantage of MEG technology is that it can precisely +measure fleeting neural activity, in contrast to the slower MRI scans. In +his experiments, Poeppel has been able to successfully record electrical +activity in the auditory cortex when people think silently of a certain +word. But the drawback is that this recording still requires the use of + + large, table-size machines to generate a magnetic pulse. + +Obviously, one wants a method that is noninvasive, portable, and +accurate. Dr. Poeppel hopes his work with MEG technology will +complement the work being done using EEG sensors. But true telepathy +helmets are still many years away, because MEG and EEG scans lack +accuracy. + +MRI IN A CELL PHONE" +"MRI IN A CELL PHONE + +At present, we are hindered by the relatively crude nature of the existing + +instruments. But, as time goes by, more and more sophisticated +instruments will probe deeper into the mind. The next big breakthrough +may be MRI machines that are handheld." +"The reason why MRI machines have to be so huge right now is that +one needs a uniform magnetic field to get good resolution. The larger +the magnet, the more uniform one can make the field, and the better +accuracy one finds in the final pictures. However, physicists know the +exact mathematical properties of magnetic fields (they were worked out +by physicist James Clerk Maxwell back in the 1860S). In 1993 in +Germany, Dr. Bernhard Bliimich and his colleagues created the world’s +smallest MRI machine, which is the size of a briefcase. It uses a weak +and distorted magnetic field, but supercomputers can analyze the +magnetic field and correct for this so that the device produces realistic 3- +D pictures. Since computer power doubles roughly every two years, they +are now powerful enough to analyze the magnetic field created by the +briefcase-sized device and compensate for its distortion." +"As a demonstration of their machine, in 2006 Dr. Bliimich and his +colleagues were able to take MRI scans of Otzi, the “Iceman,” who was +frozen in ice about 5,300 years ago toward the end of the last ice age. +Because Otzi was frozen in an awkward position, with his arms spread +apart, it was difficult to cram him inside the small cylinder of a +conventional MRI machine, but Dr. Bliimich’s portable machine easily +took MRI photographs. + +These physicists estimate that, with increasing computer power, an +MRI machine of the future might be the size of a cell phone. The raw +data from this cell phone would be sent wirelessly to a supercomputer, +which would process the data from the weak magnetic field and then +create a 3-D image. (The weakness of the magnetic field is compensated +for by the increase in computer power.) This then could vastly accelerate +research. “Perhaps something like the Star Trek tricorder is not so far off" +"after all,” Dr. Bliimich has said. (The tricorder is a small, handheld +scanning device that gives an instant diagnosis of any illness.) In the +future, you may have more computer power in your medicine cabinet +than there is in a modern university hospital today. Instead of waiting to +get permission from a hospital or university to use an expensive MRI +machine, you could gather data in your own living room by simply +waving the portable MRI over yourself and then e-mailing the results to + +a lab for analysis." +"a lab for analysis. + +It could also mean that, at some point in the future, an MRI telepathy +helmet might be possible, with vastly better resolution than an EEG +scan. Here is how it may work in the coming decades. Inside the helmet, +there would be electromagnetic coils to produce a weak magnetic field +and radio pulses that probe the brain. The raw MRI signals would then +be sent to a pocketsize computer placed in your belt. The information +would then be radioed to a server located far from the battlefield. The +final processing of the data would be done by a supercomputer in a +distant city. Then the message would be radioed back to your troops on +the battlefield. The troops would hear the message either through +speakers or through electrodes placed in the auditory cortex of their +brains. + +DARPA AND HUMAN ENHANCEMENT" +"DARPA AND HUMAN ENHANCEMENT + +Given the costs of all this research, it is legitimate to ask: Who is paying +for it? Private companies have only recently shown interest in this +cutting-edge technology, but it’s still a big gamble for many of them to +fund research that may never pay off. Instead, one of the main backers is +DARPA, the Pentagon’s Defense Advanced Research Projects Agency, +which has spearheaded some of the most important technologies of the +twentieth century. + +DARPA was originally set up by President Dwight Eisenhower after +the Russians sent Sputnik into orbit in 1957 and shocked the world. +Realizing that the United States might quickly be outpaced by the +Soviets in high technology, Eisenhower hastily established this agency to +keep the country competitive with the Russians. Over the years, the +numerous projects it started grew so large that they became independent +entities by themselves. One of its first spinoffs was NASA." +"DARPA’s strategic plan reads like something from science fiction: its +“only charter is radical innovation.” The only justification for its +existence is “to accelerate the future into being.” DARPA scientists are +constantly pushing the boundaries of what is physically possible. As + + former DARPA official Michael Goldblatt says, they try not to violate the +laws of physics, “or at least not knowingly. Or at least not more than one + +per program.”" +"per program.” + +But what separates DARPA from science fiction is its track record, +which is truly astounding. One of its early projects in the 1960s was +Arpanet, which was a war-fighting telecommunications network that +would electronically connect scientists and officials during and after +World War III. In 1989, the National Science Foundation decided that, in +light of the breakup of the Soviet bloc, it was unnecessary to keep it a +secret, so it declassified this hush-hush military technology and +essentially gave codes and blueprints away for free. Arpanet would +eventually become the Internet. + +When the U.S. Air Force needed a way to guide its ballistic missiles in +space, DARPA helped create Project 57, a top-secret project that was +designed to place H-bombs on hardened Soviet missile silos in a +thermonuclear exchange. It would later become the foundation for the +Global Positioning System (GPS). Instead of guiding missiles, today it +guides lost motorists." +"DARPA has been a key player in a series of inventions that have +altered the twentieth and twenty-first centuries, including cell phones, +night-vision goggles, telecommunications advances, and weather +satellites. I have had a chance to interact with DARPA scientists and +officials on several occasions. I once had lunch with one of the agency’s +former directors at a reception filled with many scientists and futurists. I +asked him a question that had always bothered me: Why do we have to +rely on dogs to sniff our luggage for the presence of high explosives? +Surely our sensors are sensitive enough to pick up the telltale signature +of explosive chemicals. He replied that DARPA had actively looked into +this same question but had come up against some severe technical +problems. The olfactory sensors of dogs, he said, had evolved over +millions of years to be able to detect a handful of molecules, and that +kind of sensitivity is extremely difficult to match, even with our most" +"kind of sensitivity is extremely difficult to match, even with our most +finely tuned sensors. It’s likely that we will continue to rely on dogs at +airports for the foreseeable future." +"On another occasion, a group of DARPA physicists and engineers came +to a talk I gave about the future of technology. Later I asked them if they +had any concerns of their own. One concern, they said, was their public +image. Most people have never heard of DARPA, but some link it to +dark, nefarious government conspiracies, everything from UFO cover- + + ups, Area 51, and Roswell to weather control, etc. They sighed. If only +these rumors were true, they could certainly use help from alien +technology to jump-start their research!" +"With a budget of $3 billion, DARPA has now set its sights on the +brain-machine interface. When discussing the potential applications, +former DARPA official Michael Goldblatt pushes the boundary of the +imagination. He says, “Imagine if soldiers could communicate by +thought alone.... Imagine the threat of biological attack being +inconsequential. And contemplate, for a moment, a world in which +learning is as easy as eating, and the replacement of damaged body parts +as convenient as a fast-food drive-through. As impossible as these visions +sound or as difficult as you might think the task would be, these visions +are the everyday work of the Defense Sciences Office [a branch of +DARPA].”" +"Goldblatt believes that historians will conclude that the long-term +legacy of DARPA will be human enhancement, “our future historical +strength.” He notes that the famous army slogan “Be All You Can Be” +takes on a new meaning when contemplating the implications of human +enhancement. Perhaps it is no accident that Michael Goldblatt is pushing +human enhancement so vigorously at DARPA. His own daughter suffers +from cerebral palsy and has been confined to a wheelchair all her life. +Since she requires outside help, her illness has slowed her down, but she +has always risen above adversity. She is going to college and dreaming +of starting her own company. Goldblatt acknowledges that his daughter +is his inspiration. As Washington Post editor Joel Garreau has noted, +“What he is doing is spending untold millions of dollars to create what +might well be the next step in human evolution. And yet, it has occurred +to him that the technology he is helping create might someday allow his" +"to him that the technology he is helping create might someday allow his +daughter not just to walk, but to transcend.”" +"PRIVACY ISSUES + +When hearing of mind-reading machines for the first time, the average +person might be concerned about privacy. The idea that a machine +concealed somewhere may be reading our intimate thoughts without our +permission is unnerving. Human consciousness, as we have stressed, + +involves constantly running simulations of the future. In order for these +simulations to be accurate, we sometimes imagine scenarios that wade +into immoral or illegal territory, but whether or not we act on these +plans, we prefer to keep them private. + +For scientists, life would be easier if they could simply read people’s + + thoughts from a distance using portable devices (rather than by using +clumsy helmets or surgically opening up the skull), but the laws of +physics make this exceedingly difficult." +"When I asked Dr. Nishimoto, who works in Dr. Gallant’s Berkeley lab, +about the question of privacy, he smiled and replied that radio signals +degrade quite rapidly outside the brain, so these signals would be too +diffuse and weak to make any sense to anyone standing more than a few +feet away. (In school, we learned about Newton’s laws and that gravity +diminishes as the square of the distance, so that if you doubled your +distance from a star, the gravity field diminishes by a factor of four. But +magnetic fields diminish much faster than the square of the distance. +Most signals decrease by the cube or quartic of the distance, so if you +double the distance from an MRI machine, the magnetic field goes down +by a factor of eight or more.)" +"Furthermore, there would be interference from the outside world, +which would mask the faint signals coming from the brain. This is one +reason why scientists require strict laboratory conditions to do their +work, and even then they are able to extract only a few letters, words, or +images from the thinking brain at any given time. The technology is not +adequate to record the avalanche of thoughts that often circulate in our +brain as we simultaneously consider several letters, words, phrases, or +sensory information, so using these devices for mind reading as seen in +the movies is not possible today, and won’t be for decades to come." +"For the foreseeable future, brain scans will continue to require direct +access to the human brain in laboratory conditions. But in the highly +unlikely event that someone in the future finds a way to read thoughts +from a distance, there are still countermeasures you can take. To keep +your most important thoughts private, you might use a shield to block +brain waves from entering the wrong hands. This can be done with +something called a Faraday cage, invented by the great British physicist +Michael Faraday in 1836, although the effect was first observed by +Benjamin Franklin. Basically, electricity will rapidly disperse around a" +"metal cage, such that the electric field inside the cage is zero. To +demonstrate this, physicists (like myself) have entered a metallic cage on +which huge electrical bolts are fired. Miraculously, we are unscratched. +This is why airplanes can be hit by lightning bolts and not suffer +damage, and why cable wires are covered with metallic threads. +Similarly, a telepathy shield would consist of thin metal foil placed +around the brain. + +TELEPATHY VIA NANOPROBES IN THE BRAIN" +"TELEPATHY VIA NANOPROBES IN THE BRAIN + + There is another way to partially solve the privacy issue, as well as the +difficulty of placing ECOG sensors into the brain. In the future, it may be +possible to exploit nanotechnology, the ability to manipulate individual +atoms, to insert a web of nanoprobes into the brain that can tap into +your thoughts. These nanoprobes might be made of carbon nanotubes, +which conduct electricity and are as thin as the laws of atomic physics +allow. These nanotubes are made of individual carbon atoms arrayed in +a tube a few molecules thick. (They are the subject of intense scientific +interest, and are expected in the coming decades to revolutionize the +way scientists probe the brain.)" +"The nanoprobes would be placed precisely in those areas of the brain +devoted to certain activities. In order to convey speech and language, +they would be placed in the left temporal lobes. In order to process +visual images, they would be placed in the thalamus and visual cortex. +Emotions would be sent via nanoprobes in the amygdala and limbic +system. The signals from these nanoprobes would be sent to a small +computer, which would process the signals and wirelessly send +information to a server and then the Internet. + +Privacy issues would be partially solved, since you would completely +control when your thoughts are being sent over cables or the Internet. +Radio signals can be detected by any bystander with a receiver, but +electrical signals sent along a cable cannot. The problem of opening up +the skull to use messy ECOG meshes is also solved, because the +nanoprobes can be inserted via microsurgery." +"Some science-fiction writers have conjectured that when babies are +born in the future, these nanoprobes might be painlessly implanted, so + +that telepathy becomes a way of life for them. In Star Trek, for example, +implants are routinely placed into the children of the Borg at birth so +that they can telepathically communicate with others. These children +cannot imagine a world where telepathy does not exist. They take it for +granted that telepathy is the norm. + +Because these nanoprobes are tiny, they would be invisible to the +outside world, so there would be no social ostracism. Although society +might be repulsed at the idea of inserting probes permanently into the +brain, these science-fiction writers assume that people will get used to +the idea because the nanoprobes would be so useful, just like test-tube +babies have been accepted by society today after the initial controversy +surrounding them. + +LEGAL ISSUES" +"LEGAL ISSUES + + For the foreseeable future, the question is not whether someone will be +able to read our thoughts secretly from a remote, concealed device, but +whether we will willingly allow our thoughts to be recorded. What +happens, then, if some unscrupulous person gets unauthorized access to +those files? This raises the issue of ethics, since we would not want our +thoughts to be read against our will. Dr. Brian Pasley says, “There are +ethical concerns, not with the current research, but with the possible +extensions of it. There has to be a balance. If we are somehow able to +decode someone’s thoughts instantaneously that might have great +benefits for the thousands of severely disabled people who are unable to +communicate right now. On the other hand, there are great concerns if +this were applied to people who didn’t want that.”" +"Once it becomes possible to read people’s minds and make recordings, +a host of other ethical and legal questions will arise. This happens +whenever any new technology is introduced. Historically it often takes +years before the law is fully able to address their implications. + +For instance, copyright laws may have to be rewritten. What happens +if someone steals your invention by reading your thoughts? Can you +patent your thoughts? Who actually owns the idea? + +Another problem occurs if the government is involved. As John Perry +Barlow, poet and lyricist for the Grateful Dead, once said, “Relying on" +"the government to protect your privacy is like asking a peeping tom to +install your window blinds.” Would the police be allowed to read your +thoughts when you are being interrogated? Already courts have been +ruling on cases where an alleged criminal refused to submit his DNA as +evidence. In the future, will the government be allowed to read your +thoughts without your consent, and if so, will they be admissible in +court? How reliable would they be? In the same way that MRI lie +detectors measure only increased brain activity, it’s important to note +that thinking about a crime and actually committing one are two +different things. During cross-examination, a defense lawyer might argue +that these thoughts were just random musings and nothing more." +"Another gray area concerns the rights of people who are paralyzed. If +they are drafting a will or legal document, can a brain scan be sufficient +to create a legal document? Assume that a totally paralyzed person has a +sharp, active mind and wants to sign a contract or manage his funds. Are +these documents legal, given that the technology may not be perfect? + +There is no law of physics that can resolve these ethical questions. +Ultimately, as this technology matures, these issues will have to be + + settled in court by judges and juries." +"settled in court by judges and juries. + +Meanwhile, governments and corporations might have to invent new +ways to prevent mental espionage. Industrial espionage is already a +multimillion-dollar industry, with governments and corporations +building expensive “safe rooms” that have been scanned for bugs and +listening devices. In the future (assuming that a method can be devised +to listen to brain waves from a distance), safe rooms may have to be +designed so that brain signals are not accidentally leaked to the outside +world. These safe rooms would be surrounded by metallic walls, which +would form a Faraday cage shielding the interior of the room from the +outside world." +"Every time a new form of radiation has been exploited, spies have +tried to use it for espionage, and brain waves are probably no exception. +The most famous case involved a tiny microwave device hidden in the +Great Seal of the United States in the U.S. embassy in Moscow. From +1945 until 1952, it was transmitting top-secret messages from U.S. +diplomats directly to the Soviets. Even during the Berlin Crisis of 1948 +and the Korean War, the Soviets used this bug to decipher what the +United States was planning. It might have continued to leak secrets even" +"today, changing the course of the Cold War and world history, but it was +accidentally discovered when a British engineer heard secret +conversations on an open radio band. U.S. engineers were shocked when +they picked apart the bug; they failed to detect it for years because it +was passive, requiring no energy source. (The Soviets cleverly evaded +detection because the bug was energized by microwave beams from a +remote source.) It is possible that future espionage devices will be made +to intercept brain waves as well. + +Although much of this technology is still primitive, telepathy is slowly +becoming a fact of life. In the future, we may interact with the world via +the mind. But scientists want to go beyond just reading the mind, which +is passive. They want to take an active role—to move objects with the +mind. Telekinesis is a power usually ascribed to the gods. It is the divine +power to shape reality to your wishes. It is the ultimate expression of our +thoughts and desires." +"We will soon have it. + +It is the business of the future to be dangerous.... The major +advances in civilization are processes that all but wreck the +societies in which they occur. + + —ALFRED NORTH WHITEHEAD + +4 TELEKINESIS MIND CONTROLLING MATTER + +Cathy Hutchinson is trapped inside her body. + +She was paralyzed fourteen years ago by a massive stroke. A +quadriplegic, she is like thousands of “locked-in” patients who have lost +control over most of their muscles and bodily functions. Most of the day, +she lies helpless, requiring continual nursing care, yet her mind is clear. +She is a prisoner in her own body." +"But in May 2012, her fortunes changed radically. Scientists at Brown +University placed a tiny chip on top of her brain, called Braingate, which +is connected by wires to a computer. Signals from her brain are relayed +through the computer to a mechanical robotic arm. By simply thinking, +she gradually learns to control the motion of the arm so that it can, for +instance, grab a bottled drink and bring it to her mouth. For the first +time, she is able to have some control of the world around her." +"Because she is paralyzed and cannot talk, she had to communicate her +excitement by making eye movements. A device tracks her eyes and then +translates her movements into a typed message. When she was asked +how she felt, after years of being imprisoned inside a shell called her +body, she replied, “Ecstatic!” Looking forward to the day when her other +limbs are connected to her brain via computer, she added, “I would love +to have a robotic leg support.” Before her stroke, she loved to cook and +tend her garden. “I know that someday this will happen again,” she +added. At the rate at which the field of cyber prosthetics is moving, she +might have her wish soon." +"Professor John Donoghue and his colleagues at Brown University and +also at the University of Utah have created a tiny sensor that acts like a +bridge to the outside world for those who can no longer communicate. +When I interviewed him, he told me, “We have taken a tiny sensor, the +size of a baby aspirin, or four millimeters, and implanted it onto the +surface of the brain. Because of ninety-six little ‘hairs’ or electrodes that +pick up brain impulses, it can pick up signals of your intention to move + +your arm. We target the arm because of its importance.” Because the +motor cortex has been carefully mapped over the decades, it is possible +to place the chip directly on top of the neurons that control specific +limbs." +"The key to Braingate lies in translating neural signals from the chip +into meaningful commands that can move objects in the real world, +starting with the cursor of a computer screen. Donoghue told me that he +does this by asking the patient to imagine moving the cursor of a +computer screen in a certain way, e.g., moving it to the right. It takes +only a few minutes to record the brain signals corresponding to this task. +In this way, the computer recognizes that whenever it detects a brain +signal like that, it should move the cursor to the right. + +Then, whenever that person thinks of moving the cursor to the right, +the computer actually moves the cursor in that direction. In this way, +there is a one-to-one map between certain actions that the patient +imagines and the actual action itself. A patient can immediately start to +control the movement of the cursor, practically on the first try." +"Braingate opens the door to a new world of neuroprosthetics, allowing +a paralyzed person to move artificial limbs with the mind. In addition, it +lets the patient communicate directly with their loved ones. The first +version of this chip, tested in 2004, was designed so that paralyzed +patients could communicate with a laptop computer. Soon afterward, +these patients were surfing the web, reading and writing e-mails, and +controlling their wheelchairs. + +More recently, the cosmologist Stephen Hawking had a +neuroprosthetic device attached to his glasses. Like an EEG sensor, it can +connect his thoughts to a computer so that he can maintain some contact +with the outside world. It is rather primitive, but eventually devices +similar to it will become much more sophisticated, with more channels +and greater sensitivity." +"All this, Dr. Donoghue told me, could have a profound impact on the +lives of these patients: “Another useful thing is that you can connect this +computer to any device—a toaster, a coffee maker, an air conditioner, a +light switch, a typewriter. It’s really quite easy to do these things these +days, and it’s very inexpensive. For a quadriplegic who can’t get around, +they will be able to change the TV channel, turn the lights on, and do all +those things without anybody coming into the room and doing it for + +them.” Eventually, they will be able to do anything a normal person can +do, via computers. + +FIXING SPINAL CORD INJURIES + +A number of other groups are entering the fray. Another breakthrough +was made by scientists at Northwestern University who have connected" +"a monkey’s brain directly to his own arm, bypassing an injured spinal +cord. In 1995, there was the sad story of Christopher Reeve, who soared +into outer space in the Superman movies but was completely paralyzed +due to an injury to his spinal cord. Unfortunately, he was thrown off a +horse and landed on his neck, so the spinal cord was damaged just +beneath his head. If he had lived longer, he might have seen the work of +scientists who want to use computers to replace broken spinal cords. In +the United States alone, more than two hundred thousand people have +some form of spinal cord injury. In an earlier age, these individuals +might have died soon after the accident, but because of advances in +acute trauma care, the number of people who survive these sorts of +injuries has actually grown in recent years. We are also haunted by the +images of thousands of wounded warriors who were victims of roadside +bombs in Iraq and Afghanistan. And if you include the number of" +"bombs in Iraq and Afghanistan. And if you include the number of +patients paralyzed by strokes and other illnesses, like amyotropic lateral +sclerosis (ALS), the number of patients swells to two million." +"The scientists at Northwestern used a one-hundred-electrode chip, +which was placed directly on the brain of a monkey. The signals from +the brain were carefully recorded as the monkey grasped a ball, lifted it, +and released it into a tube. Since each task corresponds to a specific +firing of neurons, the scientists could gradually decode these signals. + +When the monkey wanted to move his arm, the signals were processed +by a computer using this code, and, instead of sending the messages to a +mechanical arm, they sent the signals directly to the nerves of the +monkey’s real arm. “We are eavesdropping on the natural electrical +signals from the brain that tell the arm and hand how to move, and +sending those signals directly to the muscles,” says Dr. Lee Miller. + +By trial and error, the monkey learned to coordinate the muscles in his +arm. “There is a process of motor learning that is very similar to the" +"process you go through when you learn to use a new computer, mouse, +or a different tennis racquet,” adds Dr. Miller. + +(It is remarkable that the monkey was able to master so many motions +of his arm, given the fact that there are only one hundred electrodes on +this brain chip. Dr. Miller points out that millions of neurons are +involved in controlling the arm. The reason that one hundred electrodes +can give a reasonable approximation to the output of millions of neurons +is that the chip connects to the output neurons, after all the complex +processing has already been done by the brain. With the sophisticated +analysis out of the way, the one hundred electrodes are responsible +simply for feeding that information to the arm.) + +This device is one of several being devised at Northwestern that will" +"This device is one of several being devised at Northwestern that will + + allow patients to bypass their injured spinal cords. Another neural +prosthesis uses the motion of the shoulders to control the arm. An +upward shrug causes the hand to close. A downward shrug causes the +hand to open. The patient also has the ability to curl his fingers around +an object like a cup, or manipulate a key that is grasped between the +thumb and index finger. + +Dr. Miller concludes, “This connection from brain to muscles might +someday be used to help patients paralyzed due to spinal cord injury +perform activities of daily living and achieve greater independence.” + +REVOLUTIONIZING PROSTHETICS" +"REVOLUTIONIZING PROSTHETICS + +Much of the funding driving these remarkable developments comes from +a DARPA project called Revolutionizing Prosthetics, a $150 million +effort that has been bankrolling these efforts since 2006. One of the +driving forces behind Revolutionizing Prosthetics is retired U.S. Army +colonel Geoffrey Ling, who is a neurologist with several tours of duty in +Iraq and Afghanistan. He was appalled at the human carnage he +witnessed on the battlefield caused by roadside bombs. In previous wars, +many of these brave service members would have died on the spot. But +today, with helicopters and an extensive medical evacuation +infrastructure, many of them survive but still suffer from serious bodily +injuries. More than 1,300 service members have lost limbs after coming +back from the Middle East." +"Dr. Ling asked himself whether there was a scientific way to replace +these lost limbs. Backed by funding from the Pentagon, he asked his staff +to come up with concrete solutions within five years. When he made that +request, he was met with incredulity. He recalled, “They thought we +were crazy. But it’s in insanity that things happen.” + +Spurred into action by Dr. Ling’s boundless enthusiasm, his crew has +created miracles in the laboratory. For example, Revolutionary +Prosthetics funded scientists at the Johns Hopkins Applied Physics +Laboratory who have created the most advanced mechanical arm on +Earth, which can duplicate nearly all the delicate motions of the fingers, +hand, and arm in three dimensions. It is the same size and has the same +strength and agility as a real arm. Although it is made of steel, if you +covered it up with flesh-colored plastic, it would be nearly +indistinguishable from a real arm." +"This arm was attached to Jan Sherman, a quadriplegic who had +suffered from a genetic disease that damaged the connection between +her brain and her body, leaving her completely paralyzed from the neck + + down. At the University of Pittsburgh, electrodes were placed directly on +top of her brain, which were then connected to a computer and then to a +mechanical arm. Five months after surgery to attach the arm, she +appeared on 60 Minutes. Before a national audience, she cheerfully used +her new arm to wave, greet the host, and shake his hand. She even gave +him a fist bump to show how sophisticated the arm was. + +Dr. Ling says, “In my dream, we will be able to take this into all sorts +of patients, patients with strokes, cerebral palsy, and the elderly.” + +TELEKINESIS IN YOUR LIFE" +"TELEKINESIS IN YOUR LIFE + +Not only scientists but also entrepreneurs are looking at brain-machine +interface (BMI). They wish to incorporate many of these dazzling +inventions as a permanent part of their business plans. BMI has already +penetrated the youth market, in the form of video games and toys that +use EEG sensors so that you can control objects with the mind in both +virtual reality and the real world. In 2009, NeuroSky marketed the first +toy, Mindflex, specifically designed to use EEG sensors to move a ball +through a maze. Concentrating while wearing the Mindflex EEG device + +increases the speed of a fan within the maze and propels a tiny ball +down a pathway." +"increases the speed of a fan within the maze and propels a tiny ball +down a pathway. + +Mind-controlled video games are also blossoming. Seventeen hundred +software developers are working with NeuroSky, many of them on the +company’s $129 million Mindwave Mobile headset. These video games +use a small, portable EEG sensor wrapped around your forehead that +allows you to navigate in virtual reality, where the movements of your +avatar are controlled mentally. As you maneuver your avatar on the +video screen, you can fire weapons, evade enemies, rise to new levels, +score points, etc., as in an ordinary video game, except that everything is +hands-free. + +“There’s going to be a whole ecosystem of new players, and NeuroSky +is very well positioned to be like the Intel of this new industry,” claims +Alvaro Fernandez of SharpBrains, a market research firm." +"Besides firing virtual weapons, the EEG helmet can also detect when +your attention begins to flatten out. NeuroSky has been getting inquiries +from companies concerned about injuries to workers who lose +concentration while operating a dangerous machine or who fall asleep at +the wheel. This technology could be a lifesaver, alerting the worker or +driver that he is losing his focus. The EEG helmet would set off an alarm +when the wearer dozes off. (In Japan, this headset is already creating a + + fad among partygoers. The EEG sensors look like cat ears when you put +them on your head. The ears suddenly rise when your attention is +focused and then flatten out when it fades. At parties, people can express +romantic interest just by thinking, so you know if you are impressing +someone.)" +"But perhaps the most novel applications of this technology are being +pursued by Dr. Miguel Nicolelis of Duke University. When I interviewed +him, he told me that he thinks he can duplicate many of the devices +found only in science fiction. + +SMART HANDS AND MIND MELDS + +Dr. Nicolelis has shown that this brain-machine interface can be done +across continents. He places a monkey on a treadmill. A chip is +positioned on the monkey’s brain, which is connected to the Internet. On + +the other side of the planet, in Kyoto, Japan, signals from the monkey +are used to control a robot that can walk. By walking on the treadmill in +North Carolina, the monkey controls a robot in Japan, which executes +the same walking motion. Using only his brain sensors and the reward of +a food pellet, Dr. Nicolelis has trained these monkeys to control a +humanoid robot called CB-1 halfway around the world." +"He is also tackling one of the main problems with brain-machine +interface: the lack of feeling. Today’s prosthetic hands don’t have a sense +of touch, and hence they feel foreign; because there’s no feedback, they +might accidentally crush someone’s fingers while engaging in a +handshake. Picking up an eggshell with a mechanical arm would be +nearly impossible. + +Nicolelis hopes to circumvent this problem by having a direct brain-to- +brain interface. Messages would be sent from the brain to a mechanical +arm that has sensors, which would then send messages directly back to +the brain, thereby bypassing the stem altogether. This brain-machine- +brain interface (BMBI) could enable a clean, direct feedback mechanism +to allow for the sensation of touch." +"Dr. Nicolelis started by connecting the motor cortex of rhesus monkeys +to mechanical arms. These mechanical arms have sensors on them, +which then send signals back to the brain by electrodes connected to the +somatosensory cortex (which registers the sensation of touch). The +monkeys were given a reward after every successful trial; they learned +how to use this apparatus within four to nine trials. + + To do this, Dr. Nicolelis had to invent a new code that would +represent different surfaces (which were rough or smooth). “After a +month of practice,” he told me, “this part of the brain learns this new +code, and starts to associate this new artificial code that we created with +different textures. So this is the first demonstration that we can create a +sensory channel” that can simulate sensations of the skin." +"I mentioned to him that this idea sounds like the “holodeck” of Star +Trek, where you wander in a virtual world but feel sensations when you +bump into virtual objects, just as if they were real. This is called “haptic +technology,” which uses digital technology to simulate the sense of +touch. Nicolelis replied, “Yes, I think this is the first demonstration that +something like the holodeck will be possible in the near future.” + +The holodeck of the future might use a combination of two + +technologies. First, people in the holodeck would wear Internet contact +lenses, so that they would see an entirely new virtual world everywhere +they looked. The scenery in your contact lens would change instantly +with the push of a button. And if you touched any object in this world, +signals sent into the brain would simulate the sensation of touch, using +BMBI technology. In this way, objects in the virtual world you see inside +your contact lens would feel solid." +"Brain-to-brain interface would make possible not only haptic +technology, but also an “Internet of the mind,” or brain-net, with direct +brain-to-brain contact. In 2013, Dr. Nicolelis was able to accomplish +something straight out of Star Trek, a “mind meld” between two brains. +He started with two groups of rats, one at Duke University, the other in +Natal, Brazil. The first group learned to press a lever when seeing a red +light. The second group learned to press a lever when their brains were +stimulated by a signal sent via an implant. Their reward for pressing the +lever was a sip of water. Then Dr. Nicolelis connected the motor cortices +of the brains of both groups via a fine wire through the Internet." +"When the first group of rats saw the red light, a signal was sent over +the Internet to Brazil to the second group, which then pressed the lever. +In seven out of ten trials, the second group of rats correctly responded to +the signals sent by the first group. This was the first demonstration that +signals could be transferred and also interpreted correctly between two +brains. It’s still a far cry from the mind meld of science fiction, where +two minds merge into one, because this is still primitive and the sample +size is small, but it is a proof of principle that a brain-net might be +possible. + +In 2013, the next important step was taken when scientists went +beyond animal studies and demonstrated the first direct human brain-to- + + brain communication, with one human brain sending a message to +another via the Internet." +"brain communication, with one human brain sending a message to +another via the Internet. + +This milestone was achieved at the University of Washington, with +one scientist sending a brain signal (move your right arm) to another +scientist. The first scientist wore an EEG helmet and played a video +game. He fired a cannon by imagining moving his right arm, but was +careful not to move it physically. + +The signal from the EEG helmet was sent over the Internet to another +scientist, who was wearing a transcranial magnetic helmet carefully + +placed over the part of his brain that controlled his right arm. When the +signal reached the second scientist, the helmet would send a magnetic +pulse into his brain, which made his right arm move involuntarily, all by +itself. Thus, by remote control, one human brain could control the +movement of another." +"This breakthrough opens up a number of possibilities, such as +exchanging nonverbal messages via the Internet. You might one day be +able to send the experience of dancing the tango, bungee jumping, or +skydiving to the people on your e-mail list. Not just physical activity, but +emotions and feelings as well might be sent via brain-to-brain +communication." +"Nicolelis envisions a day when people all over the world could +participate in social networks not via keyboards, but directly through +their minds. Instead of just sending e-mails, people on the brain-net +would be able to telepathically exchange thoughts, emotions, and ideas +in real time. Today a phone call conveys only the information of the +conversation and the tone of voice, nothing more. Video conferencing is +a bit better, since you can read the body language of the person on the +other end. But a brain-net would be the ultimate in communications, +making it possible to share the totality of mental information in a +conversation, including emotions, nuances, and reservations. Minds +would be able to share their most intimate thoughts and feelings. + +TOTAL IMMERSION ENTERTAINMENT" +"TOTAL IMMERSION ENTERTAINMENT + +Developing a brain-net may also have an impact on the multibillion- +dollar entertainment industry. Back in the 1920s, the technology of tape¬ +recording sound as well as light was perfected. This set off a +transformation in the entertainment industry as it made the transition +from silent movies to the “talkies.” This basic formula of combining +sound and sight hasn’t changed much for the past century. But in the + + future, the entertainment industry may make the next transition, +recording all five senses, including smell, taste, and touch, as well as the +full range of emotions. Telepathic probes would be able to handle the +full range of senses and emotions that circulate in the brain, producing a +complete immersion of the audience in the story. Watching a romantic" +"movie or an action thriller, we would be swimming in an ocean of +sensations, as if we were really there, experiencing all the rush of +feelings and the emotions of the actors. We would smell the perfume of +the heroine, feel the terror of the victims in a horror movie, and relish +the vanquishing of the bad guys." +"This immersion would involve a radical shift in how movies are made. +First, actors would have to be trained to act out their roles with +EEG/MRI sensors and nanoprobes recording their sensations and +emotions. (This would place an added burden on the actors, who would +have to act out each scene by simulating all five senses. In the same way +that some actors could not make the transition from silent movies to the +talkies, perhaps a new generation of actors will emerge who can act out +scenes with all five senses.) Editing would require not just cutting and +splicing film, but also combining tapes of the various sensations within +each scene. And finally the audience, as they sit in their seats, would +have all these electrical signals fed into their brains. Instead of 3-D +glasses, the audience would wear brain sensors of some sort. Movie +theaters would also have to be retrofitted to process this data and then +send it to the people in the audience. + +CREATING A BRAIN-NET" +"CREATING A BRAIN-NET + +Creating a brain-net that can transmit such information would have to +be done in stages. The first step would be inserting nanoprobes into +important parts of the brain, such as the left temporal lobe, which +governs speech, and the occipital lobe, which governs vision. Then +computers would analyze these signals and decode them. This +information in turn could be sent over the Internet by fiber-optic cables. + +More difficult would be to insert these signals back into another +person’s brain, where they could be processed by the receiver. So far, +progress in this area has focused only on the hippocampus, but in the +future it should be possible to insert messages directly into other parts of +the brain corresponding to our sense of hearing, light, touch, etc. So +there is plenty of work to be done as scientists try to map the cortices of +the brain involved in these senses. Once these cortices have been +mapped—such as the hippocampus, which we’ll discuss in the next" +"chapter—it should be possible to insert words, thoughts, memories, and +experiences into another brain. + +Dr. Nicolelis writes, “It is not inconceivable that our human progeny +may indeed muster the skills, technology, and ethics needed to establish +a functional brain-net, a medium through which billions of human +beings consensually establish temporary direct contacts with fellow +human beings through thought alone. What such a colossus of collective +consciousness may look like, feel like, or do, neither I nor anyone in our +present time can possibly conceive or utter.” + +THE BRAIN-NET AND CIVILIZATION" +"A brain-net may even change the course of civilization itself. Each time a +new communication system has been introduced, it has irrevocably +accelerated changes in society, lifting us from one era to the next. In +prehistoric times, for thousands of years our ancestors were nomads +wandering in small tribes, communicating with one another through +body language and grunts. The coming of language allowed us for the +first time to communicate symbols and complex ideas, which facilitated +the rise of villages and eventually cities. Within the last few thousand +years, written language has enabled us to accumulate knowledge and +culture across generations, allowing for the rise of science, the arts, +architecture, and huge empires. The coming of the telephone, radio, and +TV extended the reach of communication across continents. The Internet +now makes possible the rise of a planetary civilization that will link all +the continents and peoples of the world. The next giant step might be a" +"the continents and peoples of the world. The next giant step might be a +planetary brain-net, in which the full spectrum of senses, emotions, +memories, and thoughts are exchanged on a global scale." +"‘WE WILL BE PART OF THEIR OPERATING SYSTEM' + +When I interviewed Dr. Nicolelis, he told me that he became interested +in science at an early age while growing up in his native Brazil. He +remembers watching the Apollo moon shot, which captured the world’s +attention. To him, it was an amazing feat. And now, he told me, his own +“moon shot” is making it possible to move any object with the mind. + +He became interested in the brain while still in high school, where he +came across a 1964 book by Isaac Asimov titled The Human Brain. But he +was disappointed by the end of the book. There was no discussion about +how all these structures interacted with one another to create the mind + + (because no one knew the answer back then). It was a life-changing +moment and he realized that his own destiny might lie in trying to +understand the secrets of the brain." +"About ten years ago, he told me, he began to look seriously into doing +research on his childhood dream. He started by taking a mouse and +letting it control a mechanical device. “We placed sensors into the mouse +which read the electrical signals from the brain. Then we transmitted +these signals to a little robotic lever that could bring water from a +fountain back to the mouse’s mouth. So the animal had to learn how to +mentally move the robotic device to bring the water back. That was the +first-ever demonstration that you could connect an animal to a machine +so that it could operate a machine without moving its own body,” he +explained to me." +"Today he can analyze not just fifty but one thousand neurons in the +brain of a monkey, which can reproduce various movements in different +parts of the monkey’s body. Then the monkey can control various +devices, such as mechanical arms, or even virtual images in cyberspace. +“We even have a monkey avatar that can be controlled by the monkey’s +thoughts without the monkey making any movement,” he told me. This +is done by having the monkey watch a video in which he sees an avatar +that represents his body. Then, by mentally commanding his body to +move, the monkey makes the avatar move in the corresponding way. + +Nicolelis envisions a day in the very near future when we will play +video games and control computers and appliances with our minds. “We + +will be part of their operating system. We will be immersed in them with +mechanisms that are very similar to the experiments that I am +describing.” + +EXOSKELETONS" +"EXOSKELETONS + +The next undertaking for Dr. Nicolelis is the Walk Again Project. Its goal +is nothing less than a complete exoskeleton for the body controlled by +the mind. At first, an exoskeleton conjures up an image of something +from the Iron Man movies. Actually, it is a special suit that encases the +entire body so that the arms and legs can move via motors. He calls it a +“wearable robot.” (See Figure 10.) + +His goal, he said, is to help the paralyzed “walk by thinking.” He plans +to use wireless technology, “so there’s nothing sticking out of the head. +... We are going to record twenty to thirty thousand neurons, to +command a whole body robotic vest, so he can think and walk again and + + move and grab objects.”" +"move and grab objects.” + +Nicolelis realizes that a series of hurdles must be overcome before the +exoskeleton becomes a reality. First, a new generation of microchips +must be created that can be placed in the brain safely and reliably for +years at a time. Second, wireless sensors must be created so the +exoskeleton can roam freely. The signals from the brain would be +received wirelessly by a computer the size of a cell phone that would +probably be attached to your belt. Third, new advances must be made in +deciphering and interpreting signals from the brain via computers. For +the monkeys, a few hundred neurons were necessary to control the +mechanical arms. For a human, you need, at minimum, several thousand +neurons to control an arm or leg. And fourth, a power supply must be +found that is portable and powerful enough to energize the entire +exoskeleton. + +Figure 10. This is the exoskeleton that Dr. Nicolelis hopes will be controlled by the mind of a totally +paralyzed person." +"(illustration credit 4.1) + +Nicolelis’s goal is a lofty one: to have a working exoskeleton suit ready +for the 2014 World Cup in Brazil, where a quadriplegic Brazilian will +deliver the opening kick. He told me proudly, “This is our Brazilian +moon shot.” + +AVATARS AND SURROGATES + +In the movie Surrogates, Bruce Willis plays an FBI agent who is +investigating mysterious murders. Scientists have created exoskeletons so +perfect that they exceed human capabilities. These mechanical creatures +are super strong, with perfect bodies. In fact, they are so perfect that +humanity has become dependent on them. People live their entire life in +pods, mentally controlling their handsome, beautiful surrogate with" +"wireless technology. Everywhere you go, you see busy “people” at work, +except they are all perfectly shaped surrogates. Their aging masters are +conveniently hidden from view. The plot takes a sharp twist, however, +when Bruce Willis discovers that the person behind these murders might +be linked to the same scientist who invented these surrogates in the first +place. That forces him to wonder whether the surrogates are a blessing +or a curse." +"And in the blockbuster movie Avatar, in the year 2154 Earth has +depleted most of its minerals, so a mining company has journeyed to a +distant moon called Pandora in the Alpha Centauri star system in search +of a rare metal, unobtanium. There are native people who inhabit this +distant moon, called the Na’vi, who live in harmony with their lush +environment. In order to communicate with the native people, specially +trained workers are placed in pods, where they learn to mentally control +the body of a genetically engineered native. Although the atmosphere is +poisonous and the environment differs radically from Earth’s, avatars +have no difficulty living in this alien world. This uneasy relationship, +however, soon collapses when the mining company finds a rich deposit +of unobtainium underneath the Na’vi’s sacred ceremonial tree. Inevitably +a conflict arises between the mining company, which wants to destroy +the sacred tree and strip-mine the land for its rare metal, and the" +"the sacred tree and strip-mine the land for its rare metal, and the +natives, who worship it. It looks like a lost cause for the natives until one +of the specially trained workers switches sides and leads the Na’vi to +victory." +"Avatars and surrogates are the stuff of science fiction today, but one +day they may become an essential tool for science. The human body is +frail, perhaps too delicate for the rigors of many dangerous missions, +including space travel. Although science fiction is filled with the heroic +exploits of brave astronauts traveling to the farthest reaches of our +galaxy, the reality is much different. Radiation in deep space is so +intense that our astronauts will have to be shielded or else face +premature aging, radiation sickness, and even cancer. Solar flares shot +from the sun can bathe a spacecraft in lethal radiation. A simple +transatlantic flight from the United States to Europe exposes you to a +millirem of radiation per hour, or roughly the same as a dental X-ray. +But in outer space, the radiation could be many times more intense, +especially in the presence of cosmic rays and solar bursts. (During" +"intense solar storms, NASA has actually warned astronauts in the space +station to move to sections where there is more shielding against +radiation.) + +In addition, there are many other dangers awaiting us in outer space, +such as micrometeorites, the effects of prolonged weightlessness, and the +problems of adjusting to different gravity fields. After just a few months +in weightlessness, the body loses a large fraction of its calcium and +minerals, leaving the astronauts incredibly weak, even if they exercise +every day. After a year in outer space, Russian astronauts had to crawl +out of their space capsules like worms. Furthermore, it is believed that +some of the effects of muscle and bone loss are permanent, so that +astronauts will feel the consequences of prolonged weightlessness for the +rest of their lives." +"The dangers of micrometeorites and intense radiation fields on the +moon are so great that many scientists have proposed using a gigantic +underground cave as a permanent lunar space station to protect our +astronauts. These caves form naturally as lava tubes near extinct +volcanoes. But the safest way of building a moon base is to have our +astronauts sit in the comfort of their living rooms. This way they would +be shielded from all the hazards found on the moon, yet through +surrogates they would be able to perform the same tasks. This could +vastly reduce the cost of manned space travel, since providing life +support for human astronauts is very expensive. + +Perhaps when the first interplanetary ship reaches a distant planet, +and an astronaut’s surrogate sets foot on this alien terrain, he or she +might start with “One small step for the mind ...”" +"One possible problem with this approach is that it takes time for +messages to go to the moon and beyond. In a little over a second, a radio +message can travel from Earth to the moon, so surrogates on the moon +could be easily controlled by astronauts on Earth. More difficult would +be communicating with surrogates on Mars, since it can take twenty +minutes or more for radio signals to reach the Red Planet. + +But surrogates have practical implications closer to home. In Japan, +the Fukushima reactor accident in 2011 caused billions of dollars in +damages. Because workers can’t enter areas with lethal levels of +radiation for more than a few minutes, the final cleanup may take up to +forty years. Unfortunately, robots are not sufficiently advanced to go" +"into these blistering radiation fields and make needed repairs. In fact, +the only robots used at Fukushima are quite primitive, basically simple +cameras placed on top of a computer sitting on wheels. A full-blown +automaton that can think for itself (or be controlled by a remote +operator) and make repairs in high-radiation fields is many decades +away." +"The lack of industrial robots caused an acute problem for the Soviets +as well during the 1986 Chernobyl accident in the Ukraine. Workers sent +directly to the accident site to put out the flames died horrible deaths +due to lethal exposure to radiation. Eventually Mikhail Gorbachev +ordered the air force to “sand bag” the reactor, dropping five thousand +tons of borated sand and cement by helicopter. Radiation levels were so +high that 250,000 workers were recruited to finally contain the accident. +Each worker could spend only a few minutes inside the reactor building +doing repairs. Many received the maximum lifetime allowed dose of +radiation. Each one got a medal. This massive project was the largest +civil engineering feat ever undertaken. It could not have been done by +today’s robots." +"The Honda Corporation has, in fact, built a robot that may eventually +go into deadly radioactive environments, but it is not ready yet. Honda’s +scientists have placed an EEG sensor on the head of a worker, which is +connected to a computer that analyzes his brain waves. The computer is +then connected to a radio that sends messages to the robot, called +ASIMO (Advanced Step in Innovative Mobility). Hence, by altering his +own brain waves, a worker can control ASIMO by pure thought. + +Unfortunately, this robot is incapable of making repairs at Fukushima +right now, since it can execute only four basic motions (all of which +involve moving its head and shoulders) while hundreds of motions are +required to make repairs at a shattered nuclear power plant. This system +is not developed enough to handle simple tasks such as turning a +screwdriver or swinging a hammer." +"Other groups have also explored the possibility of mentally controlled +robots. At the University of Washington, Dr. Rajesh Rao has created a +similar robot that is controlled by a person wearing an EEG helmet. This +shiny humanoid robot is two feet tall and is called Morpheus (after a +character in the movie The Matrix, as well as the Greek god of dreams). +A student puts on the EEG helmet and then makes certain gestures, such" +"as moving a hand, which creates an EEG signal that is recorded by a +computer. Eventually the computer has a library of such EEG signals, +each one corresponding to a specific motion of a limb. Then the robot is +programmed to move its hand whenever that EEG signal is sent to it. In +this way, if you think about moving your hand, the robot Morpheus +moves its hand as well. When you put on the EEG helmet for the first +time, it takes about ten minutes for the computer to calibrate to your +brain signals. Eventually you get the hang of making gestures with your +mind that control the robot. For example, you can have it walk toward +you, pick up a block from a table, walk six feet to another table, and +then place the block there." +"Research is also progressing rapidly in Europe. In 2012, scientists in +Switzerland at the Ecole Poly technique Federate de Lausanne unveiled +their latest achievement, a robot controlled telepathically by EEG sensors +whose controller is located sixty miles away. The robot itself looks like +the Roomba robotic vacuum cleaner now found in many living rooms. +But it is actually a highly sophisticated robot equipped with a camera +that can navigate its way through a crowded office. A paralyzed patient +can, for example, look at a computer screen, which is connected to a +video camera on the robot many miles away, and see through the eyes of +the robot. Then, by thinking, the patient is able to control the motion of +the robot as it moves past obstacles." +"In the future, one can imagine the most dangerous jobs being done by +robots controlled by humans in this fashion. Dr. Nicolelis says, “We will +likely be able to operate remotely controlled envoys and ambassadors, +robots and airships of many shapes and sizes, sent on our behalf to +explore other planets and stars in distant corners of the universe.” + +For example, in 2010 the world looked on in horror as 5 million +barrels of crude oil spilled unabated into the Gulf of Mexico. The +Deepwater Horizon spill was one of the largest oil disasters in history, +yet engineers were largely helpless for three months. Robotic subs, +which are controlled remotely, floundered for weeks trying to cap the +well because they lacked the dexterity and versatility necessary for this +underwater mission. If surrogate subs, which are much more sensitive in +manipulating tools, had been available, they might have capped the well +in the first few days of the spill, preventing billions in property damage +and lawsuits." +"Another possibility is that surrogate submarines might one day enter +the human body and perform delicate surgery from the inside. This idea +was explored in the movie Fantastic Voyage, starring Raquel Welch, in +which a submarine was shrunk down to the size of a blood cell and then +injected into the bloodstream of someone who had a blood clot in his +brain. Shrinking atoms violates the laws of quantum physics, but one +day MEMS (micro-electrical-mechanical systems) the size of cells might +be able to enter a person’s bloodstream. MEMS are incredibly small +machines that can easily fit on a pinpoint. MEMS employ the same +etching technology used in Silicon Valley, which can put hundreds of +millions of transistors on a wafer the size of your fingernail. An +elaborate machine with gears, levers, pulleys, and even motors can be +made smaller than the period at the end of this sentence. One day a +person may be able to put on a telepathy helmet and then command a" +"person may be able to put on a telepathy helmet and then command a +MEMS submarine using wireless technology to perform surgery inside a +patient." +"So MEMS technology may open up an entirely new field of medicine, +based on microscopic machines entering the body. These MEMS +submarines might even guide nanoprobes as they enter the brain so that +they connect precisely to the neurons that are of interest. In this way, +nanoprobes might be able to receive and transmit signals from the +handful of neurons that are involved in specific behaviors. The hit-or- +miss approach of inserting electrodes into the brain will be eliminated. + +THE FUTURE + +In the short term, all these remarkable advances taking place in + + laboratories around the world may alleviate the suffering of those +afflicted by paralysis and other disabilities. Using the power of their +minds, they will be able to communicate with loved ones, control their +wheelchairs and beds, walk by mentally guiding mechanical limbs, +manipulate household appliances, and lead seminormal lives." +"But in the long term, these advances could have profound economic +and practical implications for the world. By mid-century, it could +become commonplace to interact with computers directly with the mind. +Since the computer business is a multitrillion-dollar industry that can + +create young billionaires and corporations almost overnight, advances in +the mind-computer interface will reverberate on Wall Street—and also in +your living room. + +All the devices we use to communicate with computers (the mouse, +keyboards, etc.) may eventually disappear. In the future, we may simply +give mental commands and our wishes will be silently carried out by +tiny chips hidden in the environment. While sitting in our offices, taking +a stroll in the park, doing window-shopping, or just relaxing, our minds +could be interacting with scores of hidden chips, allowing us to mentally +balance our finances, arrange for theater tickets, or make a reservation." +"Artists may also make good use of this technology. If they can +visualize their artwork in their minds, then the image can be displayed +via EEG sensors on a holographic screen in 3-D. Since the image in the +mind is not as precise as the original object, the artist could then make +improvements on the 3-D image and dream up the next iteration. After +several cycles, the artist could print out the final image on a 3-D printer. + +Similarly, engineers would be able to create scale models of bridges, +tunnels, and airports by simply using their imagination. They could also +rapidly make changes in their blueprints through thought alone. +Machine parts could fly off the computer screen and into a 3-D printer." +"Some critics, however, have claimed that these telekinetic powers +have one great limitation: the lack of energy. In the movies, super beings +have the power to move mountains using their thoughts. In the movie X- +Men: The Last Stand, the super villain Magneto had the ability to move +the Golden Gate Bridge simply by pointing his fingers, but the human +body can muster only about one-fifth of a horsepower on average, which +is much too little power to perform the feats we see in the comic books. +Therefore, all the herculean feats of telekinetic super beings appear to be +pure fantasy. + +There is one solution to this energy problem, however. You may be +able to connect your thoughts to a power source, which would then" +"magnify your power millions of times. In this way, you could +approximate the power of a god. In one episode of Star Trek, the crew +journeys to a distant planet and meets a godlike creature who claims to +be Apollo, the Greek god of the sun. He can perform feats of magic that +dazzle the crew. He even claims to have visited Earth eons ago, where +the earthlings worshipped him. But the crew, not believing in gods, + +suspect a fraud. Later they figure out that this “god” just mentally +controls a hidden power source, which then performs all the magic +tricks. When this power source is destroyed, he becomes a mere mortal." +"Similarly, in the future our minds may mentally control a power +source that will then give us superpowers. For example, a construction +worker might telepathically exploit a power source that energizes heavy +machinery. Then a single worker might be able to build complex +buildings and houses just by using the power of his mind. All the heavy +lifting would be done by the power source, and the construction worker +would resemble a conductor, able to orchestrate the motion of colossal +cranes and powerful bulldozers through thought alone. + +Science is beginning to catch up to science fiction in yet another way. +The Star Wars saga was supposed to take place in a time when +civilizations span the entire galaxy. The peace of the galaxy, in turn, is +maintained by the Jedi Knights, a highly trained cadre of warriors who +use the power of the “Force” to read minds and guide their lightsabers." +"However, one need not wait until we have colonized the entire galaxy +to begin contemplating the Force. As we’ve seen, some aspects of the +Force are possible today, such as being able to tap into the thoughts of +others using ECOG electrodes or EEG helmets. But the telekinetic powers +of the Jedi Knights will also become a possibility as we learn to harness +a power source with our minds. The Jedi Knights, for example, can +summon a light-saber simply by waving their hands, but we can already +accomplish the same feat by exploiting the power of magnetism (much +as the magnet in an MRI machine can hurl a hammer across a room). By +mentally activating the power source, you can grab lightsabers from +across the room with today’s technology. + +THE POWER OF A GOD" +"THE POWER OF A GOD + +Telekinesis is a power usually reserved for a deity or a superhero. In the +universe of superheros appearing in blockbuster Hollywood movies, +perhaps the most powerful character is Phoenix, a telekinetic woman +who can move any object at will. As a member of the X-Men, she can lift +heavy machinery, hold back floods, or raise jet airplanes via the power + + of her mind. (However, when she is finally consumed by the dark side of + +her power, she goes on a cosmic rampage, capable of incinerating entire +solar systems and destroying stars. Her power is so great and +uncontrollable that it leads to her eventual self-destruction.) + +But how far can science go in harnessing telekinetic powers?" +"But how far can science go in harnessing telekinetic powers? + +In the future, even with an external power source to magnify our +thoughts, it is unlikely that people with telekinetic powers will be able +to move basic objects like a pencil or mug of coffee on command. As we +mentioned, there are only four known forces that rule the universe, and +none of them can move objects unless there is an external power source. +(Magnetism comes close, but magnetism can move only magnetic +objects. Objects made of plastic, water, or wood can easily pass through +magnetic fields.) Simple levitation, a trick found in most magicians’ +shows, is beyond our scientific capability. + +So even with an external power supply, is it unlikely that a telekinetic +person would be able to move the objects around them at will. However, +there is a technology that may come close, and that involves the ability +to change one object into another." +"The technology is called “programmable matter,” and it has become a +subject of intense research for the Intel Corporation. The idea behind +programmable matter is to create objects made of tiny “catoms,” which +are microscopic computer chips. Each catom can be controlled +wirelessly; it can be programmed to change the electrical charge on its +surface so it can bind with other catoms in different ways. By +programming the electric charges one way, the catoms bind together to +form, say, a cell phone. Push a button to change their programming, and +the catoms rearrange themselves to re-form into another object, like a +laptop." +"I saw a demonstration of this technology at Carnegie Mellon +University in Pittsburgh, where scientists have been able to create a chip +the size of a pinpoint. To exam these catoms, I had to enter a “clean +room” wearing a special white uniform, plastic boots, and a cap to +prevent even the smallest dust particle from entering. Then, under a +microscope, I could see the intricate circuitry inside each catom, which +makes it possible to program it wirelessly to change the electrical charge +on its surface. In the same way we can program software today, in the +future it may be possible to program hardware. + +The next step is to determine if these catoms can combine to form" +"The next step is to determine if these catoms can combine to form + + useful objects, and to see if they can be changed or morphed into +another object at will. It may take until mid-century before we have +working prototypes of programmable matter. Because of the complexity +of programming billions of catoms, a special computer would have to be +created to orchestrate the charge on each catom. Perhaps by the end of +this century, it will be possible to mentally control this computer so that +we can change one object into another. We would not have to memorize +the charges and configuration within an object. We would just give the +mental command to the computer to change one object into another." +"Eventually we might have catalogs listing all the various objects that +are programmable, such as furniture, appliances, and electronics. Then +by telepathically communicating with the computer, it should be +possible to change one object into another. Redecorating your living +room, remodeling your kitchen, and buying Christmas presents could all +be done mentally. + +A MORALITY TALE + +Having every wish come true is something that only a divinity can +accomplish. However, there is also a downside to this celestial power. +All technologies can be used for good or for evil. Ultimately, science is a +double-edged sword. One side of the sword can cut against poverty, +disease, and ignorance. But the other side can cut against people, in +several ways." +"These technologies could conceivably make wars even more vicious. +Perhaps one day, all hand-to-hand combat will be between two +surrogates, armed with a battery of high-tech weapons. The actual +warriors, sitting safely thousands of miles away, would unleash a +barrage of the latest high-tech weaponry with little regard for the +collateral damage they are inflicting on civilians. Although wars fought +with surrogates may preserve the lives of the soldiers themselves, they +might also cause horrendous civilian and property damage. + +The bigger problem is that this power may also be too great for any +common mortal to control. In the novel Carrie, Stephen King explored +the world of a young girl who was constantly taunted by her peers. She +was ostracized by the in-crowd and her life became a never-ending series + +of insults and humiliations. However, her tormentors did not know one +thing about her: she was telekinetic. + +After enduring the taunts and having blood splashed all over her dress" +"After enduring the taunts and having blood splashed all over her dress + + at the prom, she finally cracks. She summons all her telekinetic power to +trap her classmates and then annihilate them one by one. In a final +gesture, she decides to burn the entire school down. But her telekinetic +power was too great to control. She ultimately perishes in the fire that +she started. + +Not only can the awesome power of telekinesis backfire, but there is +another problem as well. Even if you have taken all the precautions to +understand and harness this power, it could still destroy you if, +ironically enough, it is too obedient to your thoughts and commands. +Then the very thoughts you conceive may spell your doom." +"The movie Forbidden Planet (1956) is based on a play by William +Shakespeare, The Tempest, which begins with a sorcerer and his daughter +stranded on a deserted island. But in Forbidden Planet, a professor and his +daughter are stranded on a distant planet that was once the home of the +Krell, a civilization millions of years more advanced than ours. Their +greatest achievement was to create a device that gave them the ultimate +power of telekinesis, the power to control matter in all its forms by the +mind. Anything they desired suddenly materialized before them. This +was the power to reshape reality itself to their whims. + +Yet on the eve of their greatest triumph, as they were turning on this +device the Krell disappeared without a trace. What could have possibly +destroyed this most advanced civilization?" +"When a crew of earthmen land on the planet to rescue the man and +his daughter, they find that there is a hideous monster haunting the +planet, slaughtering crew members at will. Finally, one crew member +discovers the secret behind both the Krell and the monster. Before he +dies, he gasps, “Monsters from the id.” + +Then the shocking truth suddenly dawns on the professor. The very +night that the Krell turned on their telekinesis machine, they fell asleep. +All the repressed desires from their ids then suddenly materialized. +Buried in the subconscious of these highly developed creatures were the +long-suppressed animal urges and desires of their ancient past. Every +fantasy, every dream of revenge suddenly came true, so this great +civilization destroyed itself overnight. They had conquered many worlds, + +but there was one thing they could not control: their own subconscious +minds." +"but there was one thing they could not control: their own subconscious +minds. + +That is a lesson for anyone who desires to unleash the power of the +mind. Within the mind, you find the noblest achievements and thoughts +of humanity. But you will also find monsters from the id. + + CHANGING WHO WE ARE: OUR MEMORIES AND INTELLIGENCE + +So far, we have discussed the power of science to extend our mental +abilities via telepathy and telekinesis. We basically remain the same; +these developments do nothing to change the essence of who we are. +However, there is an entirely new frontier opening up that alters the +very nature of what it means to be human. Using the very latest in +genetics, electromagnetics, and drug therapy, it may become possible in +the near future to alter our memories and even enhance our intelligence. +The idea of downloading a memory, learning complex skills overnight, +and becoming super intelligent is slowly leaving the realm of science +fiction." +"Without our memories, we are lost, cast adrift in an aimless sea of +pointless stimuli, unable to understand the past or ourselves. So what +happens if one day we can input artificial memories into our brains? +What happens when we can become a master of any discipline simply by +downloading the file into our memory? And what happens if we cannot +tell the difference between real and fake memories? Then who are we? + +Scientists are moving past being passive observers of nature to actively +shaping and molding nature. This means that we might be able to +manipulate memories, thoughts, intelligence, and consciousness. Instead +of simply witnessing the intricate mechanics of the mind, in the future it +will be possible to orchestrate them. + +So let us now answer this question: Can we download memories? + +If our brains were simple enough to be understood, we +wouldn’t be smart enough to understand them. + +—ANONYMOUS + +5 MEMORIES AND THOUGHTS MADE TO ORDER" +"—ANONYMOUS + +5 MEMORIES AND THOUGHTS MADE TO ORDER + +Neo is The One. Only he can lead a defeated humanity to victory +against the Machines. Only Neo can destroy the Matrix, which has +implanted false memories into our brains as a means to control us. + +In a now-classic scene from the film The Matrix, the evil Sentinels, +who guard the Matrix, have finally cornered Neo. It looks like +humanity’s last hope is about to be terminated. But previously Neo had + + had an electrode jacked into the back of his neck that could instantly +download martial-arts skills into his brain. In seconds, he becomes a +karate master able to take down the Sentinels with breathtaking aerial +kicks and well-placed strikes. + +In The Matrix, learning the amazing skills of a black-belt karate master +is no harder than slipping an electrode into your brain and pushing the +“download” button. Perhaps one day we, too, may be able to download +memories, which will vastly increase our abilities." +"But what happens when the memories downloaded into your brain are +false? In the movie Total Recall, Arnold Schwarzenegger has fake +memories placed into his brain, so that the distinction between reality +and fiction becomes totally blurred. He valiantly fights off the bad guys +on Mars until the end of the movie, when he suddenly realizes that he +himself is their leader. He is shocked to find that his memories of being a +normal, law-abiding citizen are totally manufactured. + +Hollywood is fond of movies that explore the fascinating but fictional +world of artificial memories. All this is impossible, of course, with +today’s technology, but one can envision a day, a few decades from now, +when artificial memories may indeed be inserted into the brain. + +HOW WE REMEMBER + +Like Phineas Gage’s, the strange case of Henry Gustav Molaison, known +in the scientific literature as simply HM, created a sensation in the field" +"of neurology that led to many fundamental breakthroughs in +understanding the importance of the hippocampus in formulating +memories." +"At the age of nine, HM suffered head injuries in an accident that +caused debilitating convulsions. In 1953, when he was twenty-five years +old, he underwent an operation that successfully relieved his symptoms. +But another problem surfaced because surgeons mistakenly cut out part +of his hippocampus. At first, HM appeared normal, but it soon became +apparent that something was terribly wrong; he could not retain new +memories. Instead, he constantly lived in the present, greeting the same +people several times a day with the same expressions, as if he were +seeing them for the first time. Everything that went into his memory +lasted only a few minutes before it disappeared. Like Bill Murray in the +movie Groundhog Day, HM was doomed to relive the same day, over and +over, for the rest of his life. But unlike Bill Murray’s character, he was +unable to recall the previous iterations. His long-term memory, however," +"was relatively intact and could remember his life before the surgery. But +without a functioning hippocampus, HM was unable to record new +experiences. For example, he would be horrified when looking in a +mirror, since he saw the face of an old man but thought he was still +twenty-five. But mercifully, the memory of being horrified would also +soon disappear into the fog. In some sense, HM was like an animal with +Level II consciousness, unable to recall the immediate past or simulate +the future. Without a functioning hippocampus, he regressed from Level +III down to Level II consciousness. + +Today, further advances in neuroscience have given us the clearest +picture yet of how memories are formed, stored, and then recalled. “It +has all come together just in the past few years, due to two technical +developments—computers and modern brain scanning,” says Dr. +Stephen Kosslyn, a neuroscientist at Harvard." +"As we know, sensory information (e.g., vision, touch, taste) must first +pass through the brain stem and onto the thalamus, which acts like a +relay station, directing the signals to the various sensory lobes of the +brain, where they are evaluated. The processed information reaches the +prefrontal cortex, where it enters our consciousness and forms what we +consider our short-term memory, which can range from several seconds +to minutes. (See Figure 11.)" +"To store these memories for a longer duration, the information must +then run through the hippocampus, where memories are broken down +into different categories. Rather than storing all memories in one area of +the brain like a tape recorder or hard drive, the hippocampus redirects +the fragments to various cortices. (Storing memories in this way is +actually more efficient than storing them sequentially. If human +memories were stored sequentially, like on computer tape, a vast +amount of memory storage would br required. In fact, in the future, even +digital storage systems may adopt this trick from the living brain, rather +than storing whole memories sequentially.) For instance, emotional +memories are stored in the amygdala, but words are recorded in the +temporal lobe. Meanwhile, colors and other visual information are +collected in the occipital lobe, and the sense of touch and movement +reside in the parietal lobe. So far, scientists have identified more than" +"reside in the parietal lobe. So far, scientists have identified more than +twenty categories of memories that are stored in different parts of the +brain, including fruits and vegetables, plants, animals, body parts, +colors, numbers, letters, nouns, verbs, proper names, faces, facial +expressions, and various emotions and sounds." +"Figure 11. This shows the path taken to create memories. Impulses from the senses pass through the +brain stem, to the + + thalamus, out to the various cortices, and then to the prefrontal cortex. They then pass to the +hippocampus to form long¬ +term memories, (illustration credit 5.1) + +A single memory—for instance, a walk in the park—involves +information that is broken down and stored in various regions of the +brain, but reliving just one aspect of the memory (e.g., the smell of +freshly cut grass) can suddenly send the brain racing to pull the +fragments together to form a cohesive recollection. The ultimate goal of +memory research is, then, to figure out how these scattered fragments +are somehow reassembled when we recall an experience. This is called +the “binding problem,” and a solution could potentially explain many +puzzling aspects of memory. For instance, Dr. Antonio Damasio has +analyzed stroke patients who are incapable of identifying a single" +"category, even though they are able to recall everything else. This is +because the stroke has affected just one particular area of the brain, +where that certain category was stored. + +The binding problem is further complicated because all our memories +and experiences are highly personal. Memories might be customized for +the individual, so that the categories of memories for one person may +not correlate with the categories of memories for another. Wine tasters, +for example, may have many categories for labeling subtle variations in +taste, while physicists may have other categories for certain equations. +Categories, after all, are by-products of experience, and different people +may therefore have different categories." +"One novel solution to the binding problem uses the fact that there are +electromagnetic vibrations oscillating across the entire brain at roughly +forty cycles per second, which can be picked up by EEG scans. One +fragment of memory might vibrate at a very precise frequency and +stimulate another fragment of memory stored in a distant part of the +brain. Previously it was thought that memories might be stored +physically close to one another, but this new theory says that memories +are not linked spatially but rather temporally, by vibrating in unison. If +this theory holds up, it means that there are electromagnetic vibrations +constantly flowing through the entire brain, linking up different regions +and thereby re-creating entire memories. Hence the constant flow of +information between the hippocampus, the prefrontal cortex, the +thalamus, and the different cortices might not be entirely neural after +all. Some of this flow may be in the form of resonance across different +brain structures." +"RECORDING A MEMORY + + Sadly, HM died in 2008 at the age of eighty-two, before he could take +advantage of some sensational results achieved by science: the ability to +create an artificial hippocampus and then insert memories into the brain. +This is something straight out of science fiction, but scientists at Wake +Forest University and the University of Southern California made history +in 2011 when they were able to record a memory made by mice and +store it digitally in a computer. This was a proof-of-principle experiment, + +in which they showed that the dream of downloading memories into the +brain might one day become reality." +"At first, the very idea of downloading memories into the brain seems +like an impossible dream, because, as we have seen, memories are +created by processing a variety of sensory experiences, which are then +stored in multiple places in the neocortex and limbic system. But as we +know from HM, there is one place through which all memories flow and +are converted into long-term memories: the hippocampus. Team leader +Dr. Theodore Berger of USC says, “If you can’t do it with the +hippocampus, you can’t do it anywhere.”" +"The scientists at Wake Forest and USC first started with the +observation, garnered from brain scans, that there are at least two sets of +neurons in a mouse’s hippocampus, called CA1 and CA3, which +communicate with each other as a new task is learned. After training +mice to press two bars, one after the other, in order to get water, the +scientists reviewed the findings and attempted to decode these messages, +which proved frustrating at first since the signals between these two sets +of neurons didn’t appear to follow a pattern. But by monitoring the +signals millions of times, they were eventually able to determine which +electrical input created which output. With the use of probes in the +mice’s hippocampi, the scientists were able to record the signals between +CA1 and CA3 when the mice learned to press the two bars in sequence." +"Then the scientists injected the mice with a special chemical, making +them forget the task. Finally they played back the memory into the same +mouse’s brain. Remarkably, the memory of the task returned, and the +mice could successfully reproduce the original task. Essentially, they had +created an artificial hippocampus with the ability to duplicate digital +memory. “Turn the switch on, the animal has the memory; turn it off +and they don’t,” says Dr. Berger. “It’s a very important step because it’s +the first time we have put all the pieces together.” + +As Joel Davis of the Office of the Chief of Naval Operations, which +sponsored this work, said, “Using implantables to enhance competency is +down the road. It’s only a matter of time.”" +"Not surprisingly, with so much at stake, this area of research is +moving very rapidly. In 2013, yet another breakthrough was made, this +time at MIT, by scientists who were able to implant not just ordinary +memories into a mouse, but false ones as well. This means that, one day, + +memories of events that never took place may be implanted into the +brain, which would have a profound impact on fields like education and +entertainment. + +The MIT scientists used a technique called optogenetics (which we will +discuss more in Chapter 8), which allows you to shine a light on specific +neurons to activate them. Using this powerful method, scientists can +identify the specific neurons responsible for certain memories." +"Let’s say that a mouse enters a room and is given a shock. The neurons +responsible for the memory of that painful event can actually be isolated +and recorded by analyzing the hippocampus. Then the mouse is placed +in an entirely different room that is totally harmless. By turning on a +light on an optical fiber, one can use optogenetics to activate the +memory of the shock, and the mouse exhibits a fear response, although +the second room is totally safe. + +In this way, the MIT scientists were able not only to implant ordinary +memories, but also memories of events that never took place. One day, +this technique may give educators the ability to implant memories of +new skills to retrain workers, or give Hollywood an entirely new form of +entertainment. + +AN ARTIFICIAL HIPPOCAMPUS" +"AN ARTIFICIAL HIPPOCAMPUS + +At present, the artificial hippocampus is primitive, able to record only a +single memory at a time. But these scientists plan to increase the +complexity of their artificial hippocampus so that it can store a variety +of memories and record them for different animals, eventually working +up to monkeys. They also plan to make this technology wireless by +replacing the wires with tiny radios so that memories can be +downloaded remotely without the need for clumsy electrodes implanted +into the brain. + +Because the hippocampus is involved with memory processing in +humans, scientists see a vast potential application in treating strokes, +dementia, Alzheimer’s, and a host of other problems that occur when +there is damage or deterioration in this region of the brain. + + Many hurdles have to be negotiated, of course. Despite all we have +learned about the hippocampus since HM, it still remains something of a" +"black box whose inner workings are largely unknown. As a result, it is +not possible to construct a memory from scratch, but once a task has +been performed and the memory processed, it is possible to record it and +play it back. + +FUTURE DIRECTIONS + +Working with the hippocampus of primates and even humans will be +more difficult, since their hippocampi are much larger and more +complex. The first step is to create a detailed neural map of the +hippocampus. This means placing electrodes at different parts of the +hippocampus to record the signals that are constantly being exchanged +between different regions. This will establish the flow of information +that constantly moves across the hippocampus. The hippocampus has +four basic divisions, CA1 to CA4, and hence scientists will record the +signals that are exchanged between them." +"The second step involves the subject performing certain tasks, after +which scientists will record the impulses that flow across the various +regions of the hippocampus, thereby recording the memory. For +example, the memory of learning a certain task, such as jumping +through a hoop, will create electrical activity in the hippocampus that +can be recorded and carefully analyzed. Then a dictionary can be +created matching the memory with the flow of information across the +hippocampus. + +Finally, step three involves making a recording of this memory and +feeding the electrical signal into the hippocampus of another subject via +electrodes, to see if that memory can been uploaded. In this fashion, the +subject may learn to jump through a hoop although it has never done so +before. If successful, scientists would gradually create a library +containing recordings of certain memories." +"It may take decades to work all the way up to human memories, but +one can envision how it might work. In the future, people may be hired +to create certain memories, like a luxury vacation or a fictitious battle. +Nanoelectrodes will be placed at various places in their brain to record +the memory. These electrodes must be extremely small so that they do +not interfere with the formation of the memory. + +The information from these electrodes will then be sent wirelessly to a + + computer and then recorded. Later a subject who wants to experience +these memories will have similar electrodes placed in his hippocampus, +and the memory will be inserted into the brain." +"(There are complications to this idea, of course. If we try to insert the +memory of physical activity, such as a martial art, we have the problem +of “muscle memory.” For example, when walking, we do not consciously +think about putting one leg in front of the other. Walking has become +second nature to us because we do it so often, and from an early age. +This means that the signals controlling our legs no longer originate +entirely in the hippocampus, but also in the motor cortex, the +cerebellum, and the basal ganglia. In the future, if we wish to insert +memories involving sports, scientists may have to decipher the way in +which memories are partially stored in other areas of the brain as well.) + +VISION AND HUMAN MEMORIES" +"VISION AND HUMAN MEMORIES + +The formation of memories is quite complex, but the approach we have +been discussing takes a shortcut by eavesdropping on the signals moving +through the hippocampus, where the sensory impulses have already +been processed. In The Matrix, however, an electrode is placed in the +back of the head to upload memories directly into the brain. This +assumes that one can decode the raw, unprocessed impulses coming in +from the eyes, ears, skin, etc., that are moving up the spinal cord and +brain stem and into the thalamus. This is much more elaborate and +difficult than analyzing the processed messages circulating in the +hippocampus." +"To give you a sense of the sheer volume of unprocessed information +that comes up the spinal cord into the thalamus, let’s consider just one +aspect: vision, since many of our memories are encoded this way. There +are roughly 130 million cells in the eye’s retina, called cones and rods; +they process and record 100 million bits of information from the +landscape at any time. + +This vast amount of data is then collected and sent down the optic +nerve, which transports 9 million bits of information per second, and on +to the thalamus. From there, the information reaches the occipital lobe, + +at the very back of the brain. This visual cortex, in turn, begins the +arduous process of analyzing this mountain of data. The visual cortex +consists of several patches at the back of the brain, each of which is +designed for a specific task. They are labeled VI to V8. + +Remarkably, the area called VI is like a screen; it actually creates a" +"Remarkably, the area called VI is like a screen; it actually creates a + + pattern on the back of your brain very similar in shape and form to the +original image. This image bears a striking resemblance to the original, +except that the very center of your eye, the fovea, occupies a much +larger area in VI (since the fovea has the highest concentration of +neurons). The image cast on VI is therefore not a perfect replica of the +landscape but is distorted, with the central region of the image taking up +most of the space. + +Besides VI, other areas of the occipital lobe process different aspects +of the image, including: + +• Stereo vision. These neurons compare the images coming in from +each eye. This is done in area V2. + +• Distance. These neurons calculate the distance to an object, using +shadows and other information from both eyes. This is done in area +V3. + +• Colors are processed in area V4." +"• Colors are processed in area V4. + +• Motion. Different circuits can pick out different classes of motion, +including straight-line, spiral, and expanding motion. This is done in +area V5. + +More than thirty different neural circuits involved with vision have +been identified, but there are probably many more. + +From the occipital lobe, the information is sent to the prefrontal +cortex, where you finally “see” the image and form your short-term +memory. The information is then sent to the hippocampus, which +processes it and stores it for up to twenty-four hours. The memory is +then chopped up and scattered among the various cortices. + +The point here is that vision, which we think happens effortlessly, +requires billions of neurons firing in sequence, transmitting millions of +bits of information per second. And remember that we have signals from +five sense organs, plus emotions associated with each image. All this" +"information is processed by the hippocampus to create a simple memory +of an image. At present, no machine can match the sophistication of this +process, so replicating it presents an enormous challenge for scientists +who want to create an artificial hippocampus for the human brain. + +REMEMBERING THE FUTURE + + If encoding the memory of just one of the senses is such a complex +process, then how did we evolve the ability to store such vast amounts of +information in our long-term memory? Instinct, for the most part, guides +the behavior of animals, which do not appear to have much of a long¬ +term memory. But as neurobiologist Dr. James McGaugh of the +University of California at Irvine says, “The purpose of memory is to +predict the future,” which raises an interesting possibility. Perhaps long¬ +term memory evolved because it was useful for simulating the future. In +other words, the fact that we can remember back into the distant past is +due to the demands and advantages of simulating the future." +"Indeed, brain scans done by scientists at Washington University in St. +Louis indicate that areas used to recall memories are the same as those +involved in simulating the future. In particular, the link between the +dorsolateral prefrontal cortex and the hippocampus lights up when a +person is engaged in planning for the future and remembering the past. +In some sense, the brain is trying to “recall the future,” drawing upon +memories of the past in order to determine how something will evolve +into the future. This may also explain the curious fact that people who +suffer from amnesia—such as HM—are often unable to visualize what +they will be doing in the future or even the very next day." +"“You might look at it as mental time travel—the ability to take +thoughts about ourselves and project them either into the past or into +the future,” says Dr. Kathleen McDermott of Washington University. She +also notes that their study proves a “tentative answer to a longstanding +question regarding the evolutionary usefulness of memory. It may just be +that the reason we can recollect the past in vivid detail is that this set of +processes is important for being able to envision ourselves in future +scenarios. This ability to envision the future has clear and compelling +adaptive significance.” For an animal, the past is largely a waste of + +precious resources, since it gives them little evolutionary advantage. But +simulating the future, given the lessons of the past, is an essential reason +why humans became intelligent. + +AN ARTIFICIAL CORTEX" +"AN ARTIFICIAL CORTEX + +In 2012 the same scientists from Wake Forest Baptist Medical Center and +the University of Southern California who created an artificial +hippocampus in mice announced an even more far-reaching experiment. +Instead of recording a memory in the mouse hippocampus, they +duplicated the much more sophisticated thinking process of the cortex of +a primate." +"They took five rhesus monkeys and inserted tiny electrodes into two +layers of their cortex, called the L2/3 and L5 layers. They then recorded +neural signals that went between these two layers as the monkeys +learned a task. (This task involved the monkeys seeing a set of pictures, +and then being rewarded if they could pick out these same pictures from +a much larger set.) With practice, the monkeys could perform the task +with 75 percent accuracy. But if the scientists fed the signal back into +the cortex as the monkey was performing the test, its performance +increased by 10 percent. When certain chemicals were given to the +monkey, its performance dropped by 20 percent. But if the recording +was fed back into the cortex, its performance exceeded its normal level. +Although this was a small sample size and there was only a modest +improvement in performance, the study still suggests that the scientists’ +recording accurately captured the decision-making process of the cortex." +"Because this study was done on primates rather than mice and +involved the cortex and not the hippocampus, it could have vast +implications when human trials begin. Dr. Sam A. Deadwyler of Wake +Forest says, “The whole idea is that the device would generate an output +pattern that bypasses the damaged area, proving an alternative +connection” in the brain. This experiment has a possible application for +patients whose neocortex has been damaged. Like a crutch, this device +would perform the thinking operation of the damaged area. + +AN ARTIFICIAL CEREBELLUM + +It should also be pointed out that the artificial hippocampus and +neocortex are but the first steps. Eventually, other parts of the brain will +have artificial counterparts. For example, scientists at Tel Aviv +University in Israel have already created an artificial cerebellum for a +rat. The cerebellum is an essential part of the reptilian brain that +controls our balance and other basic bodily functions." +"Usually when a puff of air is directed at a rat’s face, it blinks. If a +sound is made at the same time, the rat can be conditioned to blink just +by hearing the sound. The goal of the Israeli scientists was to create an +artificial cerebellum that could duplicate this feat. + +First the scientists recorded the signals entering the brain stem when +the puff of air hit the rat’s face and the sound was heard. Then the signal +was processed and sent back to the brain stem at another location. As +expected, the rats blinked upon receiving the signal. Not only is this the +first time that an artificial cerebellum functioned correctly, it is the first +time that messages were received from one part of the brain, processed, +and then uploaded into a different part of the brain." +"Commenting on this work, Francesco Sepulveda of the University of +Essex says, “This demonstrates how far we have come towards creating +circuitry that could one day replace damaged brain areas and even +enhance the power of the healthy brain.” + +He also sees great potential for artificial brains in the future, adding, +“It will likely take us several decades to get there, but my bet is that +specific, well-organized brain parts such as the hippocampus or the +visual cortex will have synthetic correlates before the end of the +century.” + +Although progress in creating artificial replacements for the brain is +moving remarkably fast given the complexity of the process, it is a race +against time when one considers the greatest threat facing our public +health system, the declining mental abilities of people with Alzheimer’s. + +ALZHEIMER’S—DESTROYER OF MEMORY" +"ALZHEIMER’S—DESTROYER OF MEMORY + +Alzheimer’s disease, some people claim, might be the disease of the +century. There are 5.3 million Americans who currently have +Alzheimer’s, and the number is expected to quadruple by 2050. Five + +percent of people from age sixty-five to seventy-four have Alzheimer’s, +but more than 50 percent of those over eighty-five have it, even if they +have no obvious risk factors. (Back in 1900, life expectancy in the +United States was forty-nine, so Alzheimer’s was not a significant +problem. But now, people over eighty are one of the fastest-growing +demographic groups in the country.)" +"In the early stages of Alzheimer’s, the hippocampus, the part of the +brain through which memories are processed, begins to deteriorate. +Indeed, brain scans clearly show that the hippocampus shrinks in +Alzheimer’s patients, but the wiring linking the prefrontal cortex to the +hippocampus also thins, leaving the brain unable to properly process +short-term memories. Long-term memories already stored throughout +the cortices of the brain remain relatively intact, at least at first. This +creates a situation where you may not remember what you just did a few +minutes ago but can clearly recall events that took place decades ago. + +Eventually, the disease progresses to the point where even basic long¬ +term memories are destroyed. The person is unable to recognize their +children or spouse and to remember who they are, and can even fall into +a comalike vegetative state. + +Sadly, the basic mechanisms for Alzheimer’s have only recently begun" +"Sadly, the basic mechanisms for Alzheimer’s have only recently begun + + to be understood. One major breakthrough came in 2012, when it was +revealed that Alzheimer’s begins with the formation of tau amyloid +proteins, which in turn accelerates the formation of beta amyloid, a +gummy, gluelike substance that clogs up the brain. (Before, it was not +clear if Alzheimer’s was caused by these plaques or whether perhaps +these plaques were by-products of a more fundamental disorder.)" +"What makes these amyloid plaques so difficult to target with drugs is +that they are most likely made of “prions,” which are misshapen protein +molecules. They are not bacteria or viruses, but nevertheless they can +reproduce. When viewed atomically, a protein molecule resembles a +jungle of ribbons of atoms tied together. This tangle of atoms must fold +onto itself correctly for the protein to assume the proper shape and +function. But prions are misshapen proteins that have folded incorrectly. +Worse, when they bump into healthy proteins, they cause them to fold +incorrectly as well. Hence one prion can cause a cascade of misshapen +proteins, creating a chain reaction that contaminates billions more. + +At present, there is no known way to stop the inexorable progression" +"At present, there is no known way to stop the inexorable progression + +of Alzheimer’s. Now that the basic mechanics behind Alzheimer’s are +being unraveled, however, one promising method is to create antibodies +or a vaccine that might specifically target these misshapen protein +molecules. Another way might be to create an artificial hippocampus for +these individuals so that their short-term memory can be restored. + +Yet another approach is to see if we can directly increase the brain’s +ability to create memories using genetics. Perhaps there are genes that +can improve our memory. The future of memory research may lie in the +“smart mouse.” + +THE SMART MOUSE" +"THE SMART MOUSE + +In 1999, Dr. Joseph Tsien and colleagues at Princeton, MIT, and +Washington University found that adding a single extra gene +dramatically boosted a mouse’s memory and ability. These “smart mice” +could navigate mazes faster, remember events better, and outperform +other mice in a wide variety of tests. They were dubbed “Doogie mice,” +after the precocious character on the TV show Doogie Howser, M.D. + +Dr. Tsien began by analyzing the gene NR2B, which acts like a switch +controlling the brain’s ability to associate one event with another. +(Scientists know this because when the gene is silenced or rendered +inactive, mice lose this ability.) All learning depends on NR2B, because +it controls the communication between memory cells of the" +"hippocampus. First Dr. Tsien created a strain of mice that lacked NR2B, +and they showed impaired memory and learning disabilities. Then he +created a strain of mice that had more copies of NR2B than normal, and +found that the new mice had superior mental capabilities. Placed in a +shallow pan of water and forced to swim, normal mice would swim +randomly about. They had forgotten from just a few days before that +there was a hidden underwater platform. The smart mice, however, went +straight to the hidden platform on the first try. + +Since then, researchers have been able to confirm these results in +other labs and create even smarter strains of mice. In 2009, Dr. Tsien +published a paper announcing yet another strain of smart mice, dubbed +“Hobbie-J” (named after a character in Chinese cartoons). Hobbie-J was +able to remember novel facts (such as the location of toys) three times" +"longer than the genetically modified strain of mouse previously thought +to be the smartest. “This adds to the notion that NR2B is a universal +switch for memory formation,” remarked Dr. Tsien. “It’s like taking +Michael Jordon and making him a super Michael Jordan,” said graduate +student Deheng Wang. + +There are limits, however, even to this new mice strain. When these +mice were given a choice to take a left or right turn to get a chocolate +reward, Hobbie-J was able to remember the correct path for much +longer than the normal mice, but after five minutes he, too, forgot. “We +can never turn it into a mathematician. They are rats, after all,” says Dr. +Tsien. + +It should also be pointed out that some of the strains of smart mice +were exceptionally timid compared to normal mice. Some suspect that, if +your memory becomes too great, you also remember all the failures and +hurts as well, perhaps making you hesitant. So there is also a potential +downside to remembering too much." +"Next, scientists hope to generalize their results to dogs, since we share +so many genes, and perhaps also to humans. + +SMART FLIES AND DUMB MICE + +The NR2B gene is not the only gene being studied by scientists for its +impact on memory. In yet another groundbreaking series of experiments, +scientists have been able to breed a strain of fruit flies with +“photographic memory,” and also a strain of mice that are amnesiac. +These experiments may eventually explain many mysteries of our long¬ +term memory, such as why cramming for an exam is not the best way to + + study, and why we remember events if they are emotionally charged. +Scientists have found that there are two important genes, the CREB +activator (which stimulates the formation of new connections between +neurons) and the CREB repressor (which suppresses the formation of +new memories)." +"Dr. Jerry Yin and Timothy Tully of Cold Spring Harbor have been +doing interesting experiments with fruit flies. Normally it takes ten trials +for them to learn a certain task (e.g., detecting an odor, avoiding a +shock). Fruit flies with an extra CREB repressor gene could not form + +lasting memories at all, but the real surprise came when they tested fruit +flies with an extra CREB activator gene. They learned the task in just one +session. “This implies these flies have a photographic memory,” says Dr. +Tully. He said they are just like students “who could read a chapter of a +book once, see it in their mind, and tell you that the answer is in +paragraph three of page two seventy-four.”" +"This effect is not just restricted to fruit flies. Dr. Alcino Silva, also at +Cold Spring Harbor, has been experimenting with mice. He found that +mice with a defect in their CREB activator gene were virtually incapable +of forming long-term memories. They were amnesiac mice. But even +these forgetful mice could learn a bit if they had short lessons with rest +in between. Scientists theorize that we have a fixed amount of CREB +activator in the brain that can limit the amount we can learn in any +specific time. If we try to cram before a test, it means that we quickly +exhaust the amount of CREB activators, and hence we cannot learn any +more—at least until we take a break to replenish the CREB activators. + +“We can now give you a biological reason why cramming doesn’t +work,” says Dr. Tully. The best way to prepare for a final exam is to +mentally review the material periodically during the day, until the +material becomes part of your long-term memory." +"This may also explain why emotionally charged memories are so vivid +and can last for decades. The CREB repressor gene is like a filter, +cleaning out useless information. But if a memory is associated with a +strong emotion, it can either remove the CREB repressor gene or increase +levels of the CREB activator gene. + +In the future, we can expect more breakthroughs in understanding the +genetic basis of memory. Not just one but a sophisticated combination of +genes is probably required to shape the enormous capabilities of the +brain. These genes, in turn, have counterparts in the human genome, so +it is a distinct possibility that we can also enhance our memory and +mental skills genetically." +"However, don’t think that you will be able to get a brain boost +anytime soon. Many hurdles still remain. First, it is not clear if these +results apply to humans. Often therapies that show great promise in +mice do not translate well to our species. Second, even if these results +can be applied to humans, we do not know what their impact will be. +For example, these genes may help improve our memory but not affect" +"our general intelligence. Third, gene therapy (i.e., fixing broken genes) is +more difficult than previously thought. Only a small handful of genetic +diseases can be cured with this method. Even though scientists use +harmless viruses to infect cells with the “good” gene, the body still sends +antibodies to attack the intruder, often rendering the therapy useless. It’s +possible that the insertion of a gene to enhance memory would face a +similar fate. (In addition, the field of gene therapy suffered a major +setback a few years ago when a patient died at the University of +Pennsylvania during a gene therapy procedure. The work of modifying +human genes therefore faces many ethical and even legal questions.)" +"Human trials, then, will progress much more slowly than animal trials. +However, one can foresee the day when this procedure might be +perfected and become a reality. Altering our genes in this way would +require no more than a simple shot in the arm. A harmless virus would +then enter our blood, which would then infect normal cells by injecting +its genes. Once the “smart gene” is successfully incorporated into our +cells, the gene becomes active and releases proteins that would increase +our memory and cognitive skills by affecting the hippocampus and +memory formation. + +If the insertion of genes becomes too difficult, another possibility is to +insert the proper proteins directly into the body, bypassing the use of +gene therapy. Instead of getting a shot, we would swallow a pill. + +A SMART PILL" +"A SMART PILL + +Ultimately, one goal of this research is to create a “smart pill” that could +boost concentration, improve memory, and maybe increase our +intelligence. Pharmaceutical companies have experimented with several +drugs, such as MEM 1003 and MEM 1414, that do seem to enhance +mental function. + +Scientists have found that in animal studies, long-term memories are +made possible by the interaction of enzymes and genes. Learning takes +place when certain neural pathways are reinforced as specific genes are +activated, such as the CREB gene, which in turn emits a corresponding +protein. Basically, the more CREB proteins circulating in the brain, the + + faster long-term memories are formed. This has been verified in studies + +on sea mollusks, fruit flies, and mice. The key property of MEM 1414 is +that it accelerates the production of the CREB proteins. In lab tests, aged +animals given MEM 1414 were able to form long-term memories +significantly faster than a control group." +"Scientists are also beginning to isolate the precise biochemistry +required in the formation of long-term memories, at both the genetic and +the molecular level. Once the process of memory formation is completely +understood, therapies will be devised to accelerate and strengthen this +key process. Not only the aged and Alzheimer’s patients but eventually +the average person may well benefit from this “brain boost.” + +CAN MEMORIES BE ERASED?" +"CAN MEMORIES BE ERASED? + +Alzheimer’s may destroy memories indiscriminately, but what about +selectively erasing them? Amnesia is one of Hollywood’s favorite plot +devices. In The Bourne Identity, Jason Bourne (played by Matt Damon), a +skilled CIA agent, is found floating in the water, left for dead. When he +is revived, he has severe memory loss. He is being relentlessly chased by +assassins who want to kill him, but he does not know who he is, what +happened, or why they want him dead. The only clue to his memory is +his uncanny ability to instinctively engage in combat like a secret agent." +"It is well documented that amnesia can occur accidentally through +trauma, such as a blow on the head. But can memories be selectively +erased? In the film Eternal Sunshine of the Spotless Mind, starring Jim +Carrey, two people meet accidentally on a train and are immediately +attracted to each other. However, they are shocked to find that they +were actually lovers years ago but have no memory of it. They learn that +they paid a company to wipe memories of each other after a particularly +bad fight. Apparently, fate has given them a second chance at love. + +Selective amnesia was taken to an entirely new level in Men in Black, +in which Will Smith plays an agent from a shadowy, secret organization +that uses the “neuralizer” to selectively erase inconvenient memories of +UFOs and alien encounters. There is even a dial to determine how far +back the memories should be erased. + +All these make for thrilling plot lines and box-office hits, but are any +of them really possible, even in the future?" +"We know that amnesia is, indeed, possible, and that there are two +basic types, depending on whether short- or long-term memory has been +affected. “Retrograde amnesia” occurs when there is some trauma or +damage to the brain and preexisting memories are lost, usually dating +from the event that caused the amnesia. This would be similar to the +amnesia faced by Jason Bourne, who lost all memories from before he +was left for dead in the water. Here the hippocampus is still intact, so +new memories can be formed even though long-term memory has been +damaged. “Anterograde amnesia” occurs when short-term memory is +damaged, so the person has difficulty forming new memories after the +event that caused the amnesia. Usually, amnesia may last for minutes to +hours due to damage to the hippocampus. (Anterograde amnesia was +featured prominently in the movie Memento, where a man is bent on +revenge for the death of his wife. The problem, however, is that his" +"revenge for the death of his wife. The problem, however, is that his +memory lasts only about fifteen minutes, so he has to continually write +messages on scraps of papers, photos, and even tattoos in order to +remember the clues he has uncovered about the murderer. By painfully +reading this trail of messages he has written to himself, he can +accumulate crucial evidence that he would have soon forgotten.)" +"The point here is that memory loss dates back to the time of the +trauma or disease, which would make the selective amnesia of +Hollywood highly improbable. Movies like Men in Black assume that +memories are stored sequentially, as in a hard disk, so you just hit the +“erase” button after a designated point in time. However, we know that +memories are actually broken up, with separate pieces stored in different +places in the brain. + +A FORGETFUL DRUG + +Meanwhile, scientists are studying certain drugs that may erase +traumatic memories that continue to haunt and disturb us. In 2009, +Dutch scientists, led by Dr. Merel Kindt, announced that they had found +new uses for an old drug called propranolol, which could act like a +“miracle” drug to ease the pain associated with traumatic memories. The +drug did not induce amnesia that begins at a specific point in time, but it +did make the pain more manageable—and in just three days, the study + +claimed." +"claimed. + +The discovery caused a flurry of headlines, in light of the thousands of +victims who suffer from PTSD (post-traumatic stress disorder). Everyone +from war veterans to victims of sexual abuse and horrific accidents could +apparently find relief from their symptoms. But it also seemed to fly in +the face of brain research, which shows that long-term memories are" +"encoded not electrically, but at the level of protein molecules. Recent +experiments, however, suggest that recalling memories requires both the +retrieval and then the reassembly of the memory, so that the protein +structure might actually be rearranged in the process. In other words, +recalling a memory actually changes it. This may be the reason why the +drug works: propranolol is known to interfere with adrenaline +absorption, a key in creating the long-lasting, vivid memories that often +result from traumatic events. “Propranolol sits on that nerve cell and +blocks it. So adrenaline can be present, but it can’t do its job,” says Dr. +James McGaugh of the University of California at Irvine. In other words, +without adrenaline, the memory fades." +"Controlled tests done on individuals with traumatic memories showed +very promising results. But the drug hit a brick wall when it came to the +ethics of erasing memory. Some ethicists did not dispute its +effectiveness, but they frowned on the very idea of a forgetfulness drug, +since memories are there for a purpose: to teach us the lessons of life. +Even unpleasant memories, they said, serve some larger purpose. The +drug got a thumbs-down from the President’s Council on Bioethics. Its +report concluded that “dulling our memory of terrible things [would] +make us too comfortable with the world, unmoved by suffering, +wrongdoing, or cruelty.... Can we become numb to life’s sharpest +sorrows without also becoming numb to its greatest joys?” + +Dr. David Magus of Stanford University’s Center for Biomedical Ethics +says, “Our breakups, our relationships, as painful as they are, we learn +from some of those painful experiences. They make us better people.”" +"Others disagree. Dr. Roger Pitman of Harvard University says that if a +doctor encounters an accident victim who is in intense pain, “should we +deprive them of morphine because we might be taking away the full +emotional experience? Who would ever argue with that? Why should +psychiatry be different? I think that somehow behind this argument +lurks the notion that mental disorders are not the same as physical + +disorders.” + +How this debate is ultimately resolved could have direct bearing on +the next generation of drugs, since propranolol is not the only one +involved. + +In 2008, two independent groups, both working with animals, +announced other drugs that could actually erase memories, not just +manage the pain they cause. Dr. Joe Tsien of the Medical College of +Georgia and his colleagues in Shanghai stated that they had actually +eliminated a memory in mice using a protein called CaMKII, while +scientists at SUNY Downstate Medical Center in Brooklyn found that the" +"molecule PKMzeta could also erase memories. Dr. Andre Fenson, one of +the authors of this second study, said, “If further work confirms this +view, we can expect to one day see therapies based on PKMzeta memory +erasure.” Not only may the drug erase painful memories, it also “might +be useful in treating depression, general anxiety, phobias, post-traumatic +stress, and addictions,” he added. + +So far, research has been limited to animals, but human trials will +begin soon. If the results transfer from animals to humans, then a +forgetful pill may be a real possibility. It will not be the kind of pill seen +in Hollywood movies (which conveniently creates amnesia at a precise, +opportune time) but could have vast medical applications in the real +world for people haunted by traumatic memories. It remains to be seen, +though, how selective this memory erasure might be in humans. + +WHAT CAN GO WRONG?" +"WHAT CAN GO WRONG? + +There may come a day, however, when we can carefully register all the +signals passing through the hippocampus, thalamus, and the rest of the +limbic system and make a faithful record. Then, by feeding this +information into our brains, we might be able to reexperience the +totality of what another person went through. Then the question is: +What can go wrong? + +In fact, the implications of this idea were explored in a movie, +Brainstorm (1983), starring Natalie Wood, which was far ahead of its +time. In the movie, scientists create the Hat, a helmet full of electrodes +that can faithfully record all the sensations a person is experiencing." +"Later, a person can have precisely the same sensory experience by +playing that tape back into his brain. For fun, one person puts on the Hat +when he is making love and tape-records the experience. Then the tape +is put into a loop so the experience is greatly magnified. But when +another person unknowingly inserts the experience into his brain, he +nearly dies because of a sensory overload. Later, one of the scientists +experiences a fatal heart attack. But before she dies, she records her final +moments on tape. When another person plays the death tape into his +brain, he, too, has a sudden heart attack and dies. + +When news of this powerful machine finally leaks out, the military +wants to seize control. This sets off a power struggle between the +military, which views it as a powerful weapon, and the original +scientists, who want to use it to unlock the secrets of the mind. + +Brainstorm prophetically highlighted not only the promise of this" +"Brainstorm prophetically highlighted not only the promise of this + + technology but also its potential pitfalls. It was meant to be science +fiction, but some scientists believe that sometime in the future, these +very issues may play out in our headlines and in our courts. + +Earlier, we saw that there have been promising developments in +recording a single memory created by a mouse. It may take until mid¬ +century before we can reliably record a variety of memories in primates +and humans. But creating the Hat, which can record the totality of +stimulation entering into the brain, requires tapping into the raw, +sensory data surging up the spinal cord and into the thalamus. It may be +late in this century before this can be done. + +SOCIAL AND LEGAL ISSUES" +"SOCIAL AND LEGAL ISSUES + +Some aspects of this dilemma may play out in our lifetimes. On one +hand, we may reach a point where we can learn calculus by simply +uploading the skill. The educational system would be turned upside +down; perhaps it would free teachers to spend more time mentoring +students and giving them one-on-one attention in areas of cognition that +are less skill-based and cannot be mastered by hitting a button. The rote +memorization necessary to become a professional doctor, lawyer, or +scientist could also be drastically reduced through this method. + +In principle, it might even give us memories of vacations that never" +"In principle, it might even give us memories of vacations that never + +happened, prizes that we never won, lovers whom we never loved, or +families that we never had. It could make up for deficiencies, creating +perfect memories of a life never lived. Parents would love this, since +they could teach their children lessons taken from real memories. The +demand for such a device could be enormous. Some ethicists fear that +these fake memories would be so vivid that we would prefer to relive +imaginary lives rather than experiencing our real ones." +"The unemployed may also benefit from being able to learn new +marketable skills by having memories implanted. Historically, millions +of workers were left behind every time a new technology was +introduced, often without any safety net. That’s why we don’t have +many blacksmiths or wagon makers anymore. They turned into +autoworkers and other industrial workers. But retraining requires a large +amount of time and commitment. If skills can be implanted into the +brain, there would be an immediate impact on the world economic +system, since we wouldn’t have to waste so much human capital. (To +some degree, the value of a certain skill may be devalued if memories +can be uploaded into anyone, but this is compensated for by the fact that +the number and quality of skilled workers would vastly increase.)" +"The tourism industry will also experience a tremendous boost. One +barrier to foreign travel is the pain of learning new customs and +conversing with new phrases. Tourists would be able to share in the +experience of living in a foreign land, rather than getting bogged down +trying to master the local currency and the details of the transportation +system. (Although uploading an entire language, with tens of thousands +of words and expressions, would be difficult, it might be possible to +upload enough information to carry on a decent conversation.)" +"Inevitably, these memory tapes will find their way onto social media. +In the future, you might be able to record a memory and upload it to the +Internet for millions to feel and experience. Previously, we discussed a +brain-net through which you can send thoughts. But if memories can be +recorded and created, you might also be able to send entire experiences. +If you just won a gold medal at the Olympic Games, why not share the +agony and the ecstasy of victory by putting your memories on the web? +Maybe the experience will go viral and billions can share in your +moment’s glory. (Children, who are often at the forefront of video games +and social media, may make a habit of recording memorable experiences" +"and uploading them onto the Internet. Like taking a picture with a cell +phone, it would be second nature to them to record entire memories. +This would require both the sender and the receiver to have nearly +invisible nanowires connecting to their hippocampus. The information +would then be sent wirelessly to a server, which would convert the +message to a digital signal that can be carried by the Internet. In this +way, you could have blogs, message boards, social media, and chat +rooms where, instead of uploading pictures and videos, you would +upload memories and emotions.) + +A LIBRARY OF SOULS" +"A LIBRARY OF SOULS + +People may also want to have a geneology of memories. When searching +records of our ancestors, we see only a one-dimensional portrait of their +lives. Throughout human history, people have lived, loved, and died +without leaving a substantial record of their existence. Mostly we just +find the birth and death dates of our relatives, with little in between. +Today we leave a long trail of electronic documents (credit card receipts, +bills, e-mails, bank statements, etc.). By default, the web is becoming a +giant repository of all the documents that describe our lives, but this still +doesn’t tell anyone much about what we were thinking or feeling. +Perhaps in the far future, the web could become a giant library +chronicling not just the details of our lives but also our consciousness." +"In the future, people might routinely record their memories so their +descendants can share the same experiences. Visiting the library of +memories for your clan, you would be able to see and feel how they +lived, and also how you fit into the larger scheme of things. + +This means that anyone could replay our lives, long after we have +died, by hitting the “play” button. If this vision is correct, it means that +we might be able to “bring back” our ancestors for an afternoon chat, +simply by inserting a disk into the library and pushing a button. + +Meanwhile, if you want to share in the experiences of your favorite +historical figures, you might be able to have an intimate look into how +they felt as they confronted major crises in their lives. If you have a role +model and wish to know how they negotiated and survived the great +defeats of their life, you could experience their memory tapes and gain" +"valuable insight. Imagine being able to share the memories of a Nobel +Prize-winning scientist. You might get clues about how great discoveries +are made. Or you might be able to share the memories of great +politicians and statesmen as they made crucial decisions that affected +world history. + +Dr. Miguel Nicolelis believes all this will one day become reality. He +says, “Each of these perennial records would be revered as a uniquely +precious jewel, one among billions of equally exclusive minds that once +lived, loved, suffered, and prospered, until they, too, become +immortalized, not clad in cold and silent gravestones, but released +through vivid thoughts, intensely lived loves, and mutually endured +sorrows.” + +THE DARK SIDE OF TECHNOLOGY" +"THE DARK SIDE OF TECHNOLOGY + +Some scientists have pondered the ethical implications of this +technology. Almost every new medical discovery caused ethical concerns +when it was introduced. Some of them had to be restricted or banned +when proven harmful (like the sleeping drug thalidomide, which caused +birth defects). Others have been so successful they changed our +conception of who we are, such as test-tube babies. When Louise Brown, +the first test-tube baby, was born in 1978, it created such a media storm +that even the pope issued a document critical of this technology. But +today, perhaps your sibling, child, spouse, or even you may be a product +of in vitro fertilization. Like many technologies, eventually the public +will simply get used to the idea that memories can be recorded and +shared." +"Other bioethicists have different worries. What happens if memories +are given to us without our permission? What happens if these memories +are painful or destructive? Or what about Alzheimer’s patients, who are +eligible for memory uploads but are too sick to give permission? + +The late Bernard Williams, a philosopher at Oxford University, +worried that this device might disturb the natural order of things, which +is to forget. “Forgetting is the most beneficial process we possess,” he +says. + +If memories can be implanted like uploading computer files, it could" +"If memories can be implanted like uploading computer files, it could + +also shake the foundation of our legal system. One of the pillars of +justice is the eyewitness account, but what would happen if fake +memories were implanted? Also, if the memory of a crime can be +created, then it might secretly be implanted into the brain of an innocent +person. Or, if a criminal needs an alibi, he could secretly implant a +memory into another person’s brain, convincing him that they were +together when the crime was being committed. Furthermore, not just +verbal testimony but also legal documents would be suspect, since when +we sign affidavits and legal documents, we depend on our memory to +clarify what is true and false." +"Safeguards would have to be introduced. Laws will have to be passed +that clearly define the limits of granting or denying access to memories. +Just as there are laws limiting the ability of the police or third parties to +enter your home, there would be laws to prevent people from accessing +your memories without your permission. There would also have to be a +way to mark these memories so that the person realizes that they are +fake. Thus, he would still be able to enjoy the memory of a nice +vacation, but he would also know that it never happened." +"Taping, storing, and uploading our memories may allow us to record +the past and master new skills. But doing so will not alter our innate +ability to digest and process this large body of information. To do that, +we need to enhance our intelligence. Progress in this direction is +hindered by the fact that there is no universally accepted definition of +intelligence. However, there is one example of genius and intelligence +that no one can dispute, and that is Albert Einstein. Remarkably, sixty +years after his death, his brain is still yielding invaluable clues to the +nature of intelligence. + +Some scientists believe that, using a combination of electromagnetics, +genetics, and drug therapy, it may be possible to boost our intelligence +to the genius level. They cite the fact that random injuries to the brain +have been documented that can suddenly change a person of normal +ability into a “savant,” one whose spectacular mental and artistic ability" +"is off the scale. This can be achieved now by random accidents, but what +happens when science intervenes and illuminates the secret of this +process? + +The brain is wider than the sky +For, put them side by side +The one the other will contain +With ease, and you beside. + +—EMILY DICKINSON + +Talent hits a target no one else can hit. Genius hits a target no +one else can see. + +—ARTHUR SCHOPENHAUER + +6 EINSTEIN’S BRAIN AND ENHANCING OUR +INTELLIGENCE + +Albert Einstein’s brain is missing. + +Or, at least it was for fifty years, until the heirs of the doctor who +spirited it away shortly after his death in 1955 finally returned it to the +National Museum of Health and Medicine in 2010. Analysis of his brain +may help clarify these questions: What is genius? How do you measure +intelligence and its relationship to success in life? There are also +philosophical questions: Is genius a function of our genes, or is it more a +question of personal struggle and achievement?" +"And, finally, Einstein’s brain may help answer the key question: Can +we boost our own intelligence? + +The word “Einstein” is no longer a proper noun that refers to a specific +person. It now simply means “genius.” The picture that the name +conjures up (baggy pants, flaming white hair, disheveled looks) is +equally iconic and instantly recognizable. + +The legacy of Einstein has been enormous. When some physicists in +2011 raised the possibility that he was wrong, that particles could break +the light barrier, it created a firestorm of controversy in the physics +world that spilled over into the popular press. The very idea that +relativity, which forms the cornerstone of modern physics, could be +wrong had physicists around the world shaking their heads. As expected, +once the result was recalibrated, Einstein was shown to be right once + + again. It is always dangerous to go up against Einstein." +"again. It is always dangerous to go up against Einstein. + +One way to gain insight into the question “What is genius?” is to +analyze Einstein’s brain. Apparently on the spur of the moment, Dr. +Thomas Harvey, the doctor at the Princeton hospital who was +performing the autopsy on Einstein, decided to secretly preserve his +brain, against the knowledge and wishes of Einstein’s family. + +Perhaps he preserved Einstein’s brain with the vague notion that one +day it might unlock the secret of genius. Perhaps he thought, like many + +others, that there was a peculiar part of Einstein’s brain that was the seat +of his vast intelligence. Brian Burrell, in his book Postcards from the Brain +Museum, speculates that perhaps Dr. Harvey “got caught up in the +moment and was transfixed in the presence of greatness. What he +quickly discovered was that he had bitten off more than he could chew.”" +"What happened to Einstein’s brain after that sounds more like a +comedy than a science story. Over the years, Dr. Harvey promised to +publish his results of analyzing Einstein’s brain. But he was no brain +specialist, and kept making excuses. For decades, the brain sat in two +large mason jars filled with formaldehyde and placed in a cider box, +under a beer cooler. He had a technician slice the brain into 240 pieces, +and on rare occasions he would mail a few to scientists who wanted to +study them. Once, pieces were mailed to a scientist at Berkeley in a +mayonnaise container." +"Forty years later, Dr. Harvey drove across the country in a Buick +Skylark carrying Einstein’s brain in a Tupperware container, hoping to +return it to Einstein’s granddaughter Evelyn. She refused to accept it. +After Dr. Harvey’s death in 2007, it was left to his heirs to properly +donate his collection of slides and portions of Einstein’s brain to science. +The history of Einstein’s brain is so unusual that a TV documentary was +filmed about it. + +(It should be pointed out that Einstein’s brain was not the only one to +be preserved for posterity. The brain of one of the greatest geniuses of +mathematics, Carl Friedrich Gauss, often called the Prince of +Mathematicians, was also preserved by a doctor a century earlier. Back +then, the anatomy of the brain was largely unexplored, and no +conclusions could be drawn other than the fact that it had unusually +large convolutions or folds.)" +"One might expect that Einstein’s brain was far beyond an ordinary +human’s, that it must have been huge, perhaps with areas that were +abnormally large. In fact, the opposite has been found (it is slightly +smaller, not larger, than normal). Overall, Einstein’s brain is quite + + ordinary. If a neurologist did not know that this was Einstein’s brain, he +probably would not give it a second thought. + +The only differences found in Einstein’s brain were rather minor. A +certain part of his brain, called the angular gyri, was larger than normal, +with the inferior parietal regions of both hemispheres 15 percent wider" +"than average. Notably, these parts of the brain are involved in abstract +thought, in the manipulation of symbols such as writing and +mathematics, and in visual-spatial processing. But his brain was still +within the norm, so it is not clear whether the genius of Einstein lay in +the organic structure of his brain or in the force of his personality, his +outlook, and the times. In a biography that I once wrote of Einstein, +titled Einstein’s Cosmos, it was clear to me that certain features of his life +were just as important as any anomaly in his brain. Perhaps Einstein +himself said it best when he said, “I have no special talents.... I am only +passionately curious.” In fact, Einstein would confess that he had to +struggle with mathematics in his youth. To one group of schoolchildren, +he once confided, “No matter what difficulties you may have with +mathematics, mine were greater.” So why was Einstein Einstein?" +"First, Einstein spent most of his time thinking via “thought +experiments.” He was a theoretical physicist, not an experimental one, +so he was continually running sophisticated simulations of the future in +his head. In other words, his laboratory was his mind." +"Second, he was known to spend up to ten years or more on a single +thought experiment. From the age of sixteen to twenty-six, he focused on +the problem of light and whether it was possible to outrace a light beam. +This led to the birth of special relativity, which eventually revealed the +secret of the stars and gave us the atomic bomb. From the age of twenty- +six to thirty-six, he focused on a theory of gravity, which eventually gave +us black holes and the big-bang theory of the universe. And then from +the age of thirty-six to the end of his life, he tried to find a theory of +everything to unify all of physics. Clearly, the ability to spend ten or +more years on a single problem showed the tenacity with which he +would simulate experiments in his head." +"Third, his personality was important. He was a bohemian, so it was +natural for him to rebel against the establishment in physics. Not every +physicist had the nerve or the imagination to challenge the prevailing +theory of Isaac Newton, which had held sway for two hundred years +before Einstein. + +Fourth, the time was right for the emergence of an Einstein. In 1905, +the old physical world of Newton was crumbling in light of experiments +that clearly suggested a new physics was about to be born, waiting for a + + genius to show the way. For example, the mysterious substance called + +radium glowed in the dark all by itself indefinitely, as if energy was +being created out of thin air, violating the theory of conservation of +energy. In other words, Einstein was the right man for the times. If +somehow it becomes possible to clone Einstein from the cells in his +preserved brain, I suspect that the clone would not be the next Einstein. +The historic circumstances must also be right to create a genius." +"The point here is that genius is perhaps a combination of being born +with certain mental abilities and also the determination and drive to +achieve great things. The essence of Einstein’s genius was probably his +extraordinary ability to simulate the future through thought +experiments, creating new physical principles via pictures. As Einstein +himself once said, “The true sign of intelligence is not knowledge, but +imagination.” And to Einstein, imagination meant shattering the +boundaries of the known and entering the domain of the unknown. + +All of us are born with certain abilities that are programmed into our +genes and the structure of our brains. That is the luck of the draw. But +how we arrange our thoughts and experiences and simulate the future is +something that is totally within our control. Charles Darwin himself once +wrote, “I have always maintained that, excepting fools, men did not +differ much in intellect, only in zeal and hard work.” + +CAN GENIUS BE LEARNED?" +"CAN GENIUS BE LEARNED? + +This rekindles the question, Are geniuses made or born? How does the +nature/nurture debate solve the mystery of intelligence? Can an ordinary +person become a genius? + +Since brain cells are notoriously hard to grow, it was once thought +that intelligence was fixed by the time we became young adults. But one +thing is becoming increasingly clear with new brain research: the brain +itself can change when it learns. Although brain cells are not being +added in the cortex, the connections between neurons are changing +every time a new task is learned. + +For example, scientists in 2011 analyzed the brains of London’s +famous taxicab drivers, who have to laboriously memorize twenty-five +thousand streets in the dizzying maze that makes up modern London. It +takes three to four years to prepare for this arduous test, and only half + + the trainees pass." +"the trainees pass. + +Scientists at University College London studied the brains of these +drivers before they took the test, and then tested them again three to +four years afterward. Those trainees who passed the test had a larger +volume of gray matter than before, in an area called the posterior and +the anterior hippocampus. The hippocampus, as we’ve seen, is where +memories are processed. (Curiously, tests also showed that these taxicab +drivers scored less than normal on processing visual information, so +perhaps there is a trade-off, a price to pay for learning this volume of +information.) + +“The human brain remains ‘plastic,’ even in adult life, allowing it to +adapt when we learn new tasks,” says Eleanor Maguire of the Wellcome +Trust, which funded the study. “This offers encouragement for adults +who want to learn new skills later in life.”" +"Similarly, the brains of mice that have learned many tasks are slightly +different from the brains of other mice that have not learned these tasks. +It is not so much that the number of neurons has changed, but rather +that the nature of the neural connections has been altered by the +learning process. In other words, learning actually changes the structure +of the brain. + +This raises the old adage “practice makes perfect.” Canadian +psychologist Dr. Donald Hebb discovered an important fact about the +wiring of the brain: the more we exercise certain skills, the more certain +pathways in our brains become reinforced, so the task becomes easier. +Unlike a digital computer, which is just as dumb today as it was +yesterday, the brain is a learning machine with the ability to rewire its +neural pathways every time it learns something. This is a fundamental +difference between a digital computer and the brain." +"This lesson applies not only to London taxicab drivers, but also to +accomplished concert musicians as well. According to psychologist Dr. K. +Anders Ericsson and colleagues, who studied master violinists at Berlin’s +elite Academy of Music, top concert violinists could easily rack up ten +thousand hours of grueling practice by the time they were twenty years +old, practicing more than thirty hours per week. By contrast, he found +that students who were merely exceptional studied only eight thousand +hours or fewer, and future music teachers practiced only a total of four +thousand hours. Neurologist Daniel Levitin says, “The emerging picture + +from such studies is that ten thousand hours of practice is required to +achieve the level of mastery associated with being a world-class expert— +in anything.... In study after study, of composers, basketball players, +fiction writers, ice skaters, concert pianists, chess players, master" +"criminals, and what have you, this number comes up again and again.” +Malcolm Gladwell, writing in the book Outliers, calls this the “10,000- +hour rule.” + +HOW DO YOU MEASURE INTELLIGENCE? + +But how do you measure intelligence? For centuries, any discussion of +intelligence relied on hearsay and anecdote. But now MRI studies have +shown that the principal activity of the brain while performing these +mathematical puzzles involves the pathway connecting the prefrontal +cortex (which engages in rational thought) with the parietal lobes +(which processes numbers). This correlates with the anatomical studies +of Einstein’s brain, which showed that his inferior parietal lobes were +larger than normal. So it is conceivable that mathematical ability +correlates with increased information flows between the prefrontal +cortex and the parietal lobes. But did the brain increase in size in this +area because of hard work and study, or was Einstein born that way? +The answer is still not clear." +"The key problem is that there is no uniformly accepted definition of +intelligence, let alone a consensus among scientists as to its origin. But +the answer may prove critical if we wish to enhance it. + +IQ EXAMS AND DR. TERMAN + +By default, the most widely used measure of intelligence is the IQ exam, +pioneered by Dr. Lewis Terman of Stanford University, who in 1916 +revised an earlier test devised by Alfred Binet for the French +government. For the next several decades, it became the gold standard +by which to measure intelligence. Terman, in fact, dedicated his life to +the proposition that intelligence could be measured and inherited, and +was the strongest predictor of success in life. + +Five years later, Terman started a landmark study on schoolchildren," +"Five years later, Terman started a landmark study on schoolchildren, + +The Genetic Studies of Genius. It was an ambitious project, whose scope +and duration were unprecedented back in the 1920s. It set the tone for +research in this field for an entire generation. He methodically +chronicled the successes and failures of these individuals throughout +their lives, compiling thick files of their achievements. These high-IQ +students were dubbed the “Termites.” + +At first, Dr. Terman’s idea seemed to be a resounding success. It" +"At first, Dr. Terman’s idea seemed to be a resounding success. It + + became the standard by which both children and other tests were +measured. During World War I, 1.7 million soldiers were given this test. +But over the years, a different profile began to slowly emerge. Decades +later, children who scored high on the IQ exam were only moderately +more successful than those who did not. Terman could proudly point to +some of his students who went on to win awards and secure well-paying +jobs. But he became increasingly disturbed by the large number of his +brightest students whom society would consider to be failures, taking +menial, dead-end jobs, engaging in crime, or leading lives on the +margins of society. These results were quite upsetting to Dr. Terman, +who had dedicated his life to proving that high IQ meant success in life. + +SUCCESS IN LIFE AND DELAYED GRATIFICATION" +"SUCCESS IN LIFE AND DELAYED GRATIFICATION + +A different approach was taken in 1972 by Dr. Walter Mischel, also of +Stanford, who analyzed yet another characteristic among children: the +ability to delay gratification. He pioneered the use of the “marshmallow +test,” that is, would children prefer one marshmallow now, or the +prospect of two marsh-mallows twenty minutes later? Six hundred +children, aged four to six, participated in this experiment. When Mischel +revisited the participants in 1988, he found that those who could delay +gratification were more competent than those who could not." +"In 1990, another study showed a direct correlation between those who +could delay gratification and SAT scores. And a study done in 2011 +indicated that this characteristic continued throughout a person’s life. +The results of these and other studies were eye-opening. The children +who exhibited delayed gratification scored higher on almost every +measure of success in life: higher-paying jobs, lower rates of drug +addiction, higher test scores, higher educational attainment, better social + +integration, etc." +"integration, etc. + +But what was most intriguing was that brain scans of these individuals +revealed a definite pattern. They showed a distinct difference in the way +the prefrontal cortex interacted with the ventral striatum, a region +involved in addiction. (This is not surprising, since the ventral striatum +contains the nucleus accumbens, known as the “pleasure center.” So +there seems to be a struggle here between the pleasure-seeking part of +the brain and the rational part to control temptation, as we saw in +Chapter 2.) + +This difference was no fluke. The result has been tested by many +independent groups over the years, with nearly identical results. Other +studies have also verified the difference in the frontal-striatal circuitry of + + the brain, which appears to govern delayed gratification. It seems that +the one characteristic most closely correlated with success in life, which +has persisted over the decades, is the ability to delay gratification." +"Although this is a gross simplification, what these brain scans show is +that the connection between the prefrontal and parietal lobes seems to +be important for mathematical and abstract thought, while the +connection between the prefrontal and limbic system (involving the +conscious control of our emotions and pleasure center) seems to be +essential for success in life. + +Dr. Richard Davidson, a neuroscientist at the University of Wisconsin- +Madison, concludes, “Your grades in school, your scores on the SAT, +mean less for life success than your capacity to co-operate, your ability +to regulate your emotions, your capacity to delay your gratification, and +your capacity to focus your attention. Those skills are far more +important—all the data indicate—for life success than your IQ or your +grades.” + +NEW MEASURES OF INTELLIGENCE" +"NEW MEASURES OF INTELLIGENCE + +Clearly there have to be new ways to measure intelligence and success in +life. IQ exams are not useless, but they measure only one limited form of +intelligence. Dr. Michael Sweeney, author of Brain: The Complete Mind, +notes, “Tests don’t measure motivation, persistence, social skills, and a +host of other attributes of a life that’s well lived.”" +"The problem with many of these standardized tests is that there may +also be a subconscious bias due to cultural influences. In addition, these +tests are evaluating only one particular form of intelligence, which some +psychologists call “convergent” intelligence. Convergent intelligence +focuses on one line of thought, ignoring the more complex “divergent” +form of intelligence, which involves measuring differing factors. For +example, during World War II, the U.S. Army Air Forces asked scientists +to devise a psychological exam that would measure a pilot’s intelligence +and ability to handle difficult, unexpected situations. One question was: +If you are shot down deep in enemy territory and must somehow make it +back to friendly lines, what do you do? The results contradicted +conventional thinking." +"Most psychologists expected that the air force study would show that +pilots with high IQs would score highly on this test as well. Actually, the +reverse was true. The pilots who scored highest were the ones with +higher levels of divergent thinking, who could see through many +different lines of thought. Pilots who excelled at this, for example, were +able to think up a variety of unorthodox and imaginative methods to + + escape after they were captured behind enemy lines." +"escape after they were captured behind enemy lines. + +The difference between convergent and divergent thinking is also +reflected in studies on split-brain patients, which clearly show that each +hemisphere of the brain is principally hardwired for one or the other. Dr. +Ulrich Kraft of Fulda, Germany, writes, “The left hemisphere is +responsible for convergent thinking and the right hemisphere for +divergent thinking. The left side examines details and processes them +logically and analytically but lacks a sense of overriding, abstract +connections. The right side is more imaginative and intuitive and tends +to work holistically, integrating pieces of an informational puzzle into a +whole.”" +"In this book, I take the position that human consciousness involves the +ability to create a model of the world and then simulate the model into +the future, in order to attain a goal. Pilots who demonstrated divergent +thinking were able to simulate many possible future events accurately +and with more complexity. Similarly, the children who mastered delayed +gratification in the famous marshmallow test appear to be the ones who +had the most ability to simulate the future, to see the long-term rewards +and not just the short-term, get-rich-quick schemes." +"A more sophisticated intelligence exam that directly quantifies a +person’s ability to simulate the future would be difficult but not +impossible to create. A person could be asked to create as many realistic +scenarios for the future as possible to win a game, with a score assigned +depending on the number of simulations the person can imagine and the +number of causal links involved with each one. Instead of measuring a +person’s ability to simply assimilate information, this new method would +measure a person’s ability to manipulate and mold this information to +achieve a higher goal. For example, a person might be asked to figure +out how to escape from a deserted island full of hungry wild animals and +poisonous snakes. He would have to list all the various ways to survive, +fend off the dangerous animals, and leave the island, creating an +elaborate causal tree of possible outcomes and futures." +"So we see that there is a common thread running through all this +discussion, and that is that intelligence seems to be correlated with the +complexity with which we can simulate future events, which correlates +with our earlier discussion of consciousness. + +But given the rapid advances taking place in the world’s laboratories +concerning electromagnetic fields, genetics, and drug therapies, is it +possible not just to measure our intelligence, but to enhance it as well— +to become another Einstein? + + BOOSTING OUR INTELLIGENCE + +This possibility was explored in the novel Flowers for Algernon (1958), +later made into the Academy Award-winning movie Charly (1968). In it, +we follow the sad life of Charly Gordon, who has an IQ of 68 and a +menial job in a bakery. He lives a simple life, fails to understand that his +fellow workers are constantly making fun of him, and does not even +know how to spell his own name." +"His only friend is Alice, a teacher who takes pity on him and tries to +teach him to read. But one day, scientists discover a new procedure that +can suddenly make ordinary mice intelligent. Alice hears about this and +decides to introduce Charly to these scientists, who agree to perform the +procedure on their first human subject. Within weeks, Charly has +noticeably changed. His vocabulary increases, he devours books from the + +library, he becomes something of a ladies’ man, and his room explodes +with modern art. Soon he begins to read about relativity and the +quantum theory, pushing the boundaries of advanced physics. He and +Alice even become lovers." +"But then the doctors notice that the mice have slowly lost their ability +and died. Realizing that he, too, might lose everything, Charly furiously +tries to use his superior intellect to find a cure, but instead he’s forced to +witness his own inexorable decline. His vocabulary shrinks, he forgets +mathematics and physics, and he slowly reverts back to his old self. In +the final scene, a heartbroken Alice watches as Charly plays with +children. + +The novel and movie, although poignant and critically acclaimed, +were dismissed as sheer science fiction. The plot was moving and +original, but the idea of boosting one’s intelligence was considered +preposterous. Brain cells cannot regenerate, scientists said, so this +movie’s plot was obviously impossible. + +But not anymore." +"But not anymore. + +Although it is still impossible to boost your intelligence, rapid +advances are being made in electromagnetic sensors, genetics, and stem +cells that may one day make this a real possibility. In particular, +scientific interest has focused on “autistic savants,” who possess +phenomenal, superhuman abilities that stagger the imagination. More +important, due to specific injuries to the brain, normal people can +rapidly acquire such near-miraculous powers. Some scientists even +believe that these uncanny abilities might be induced using +electromagnetic fields. + + SAVANTS: SUPER GENIUSES? + +A bullet went crashing through the skull of Mr. Z when he was nine +years old. It did not kill him, as his doctors feared, but wreaked +extensive damage to the left side of his brain, causing paralysis of the +right side of his body and leaving him permanently deaf and mute." +"However, the bullet also had a bizarre side effect. Mr. Z developed +supernormal mechanical abilities and a prodigious memory, typical of +“savants.” + +Mr. Z is not alone. In 1979, a ten-year-old boy named Orlando Serrell +was knocked unconscious by a baseball that hit the left side of his head. +At first, he complained of severe headaches. But after the pain subsided, +he was able to do remarkable mathematical calculations and had a near¬ +photographic memory of certain events happening in his life. He could +calculate dates thousands of years into the future. + +In the entire world of roughly seven billion people, there are only +about one hundred documented cases of these astounding savants. (The +number is much larger if we include those whose mental skills are still +extraordinary but not superhuman. It is believed that about 10 percent +of autistic individuals show some savant capabilities.) These +extraordinary savants possess abilities far beyond our current scientific +understanding." +"There are several types of savants that have recently elicited the +curiosity of scientists. About half of savants have some form of autism +(the other half display other forms of mental illness or psychological +disorder). They often have profound problems interacting socially, +leading to deep isolation. + +Then there is the “acquired savant syndrome,” in which people who +appear perfectly normal suffer from some extreme trauma later in life +(e.g., hitting their head on the bottom of a swimming pool or being +struck by a baseball or a bullet), almost always on the left side of their +brain. Some scientists, however, suggest that this distinction is +misleading, that perhaps all savant skills are acquired. Since autistic +savants begin to show their abilities around age three or four, perhaps +their autism (like a blow to their head) is the origin of their abilities." +"There is scientific disagreement about the origin of these extraordinary +abilities. Some believe that these individuals are simply born this way +and hence are unique, one-of-a-kind anomalies. Their skills, even if + + awakened by a bullet, are hardwired into their brains from birth. If so, +then perhaps this skill can never be learned or transferred. + +Others claim that such hardwiring violates the theory of evolution, +which takes place incrementally over long periods of time. If savant +geniuses exist, then the rest of us must also possess similar abilities, +although they are latent. Does this mean, then, that one day we might be +able to turn on these miraculous powers at will? Some believe so, and +there are even published papers claiming that some savant skills are" +"latent in all of us and can be brought to light using the magnetic fields +generated by an electromagnetic scanner (TES). Or perhaps there is a +genetic basis to this skill, in which case gene therapy might re-create +these astonishing abilities. It might also be possible to cultivate stem +cells that would allow neurons to grow in the prefrontal cortex and other +key centers of the brain. Then we might be able to increase our mental +abilities. + +All these avenues are the source of much speculation and research. +Not only might they allow doctors to reverse the ravages of diseases like +Alzheimer’s, but they could also enable us to enhance our own +intelligence. The possibilities are intriguing." +"The first documented case of a savant was recorded in 1789 by Dr. +Benjamin Rush, who studied an individual who seemed to be mentally +handicapped. Yet when he was asked how many seconds a man had +lived (who was seventy years, seventeen days, and twelve hours old), it +took him only ninety seconds to give the correct answer of +2,210,500,800. + +Dr. Darold Treffert, a Wisconsin physician, has studied these savants at +length. He recites one story of a blind savant who was asked a simple +question. If you put one corn kernel in the first square of a chess board, +two kernels in the second, four in the next, and keep doubling after that, +how many kernels would you have on the sixty-fourth square? It took +him just forty-five seconds to correctly reply: +18,446,744,073,709,551,616." +"Perhaps the best-known example of a savant was the late Kim Peek, +who was the inspiration for the movie Rain Man, starring Dustin +Hoffman and Tom Cruise. Although Kim Peek was severely mentally +handicapped (he was incapable of living by himself and could barely tie +his shoelaces or button his shirt), he memorized about twelve thousand +books and could recite lines from them, word for word, on any particular +page. It took him about eight seconds to read a page. (He could +memorize a book in about half an hour, but he read them in an unusual +way. He could read both pages simultaneously, using each eye to read a + + different page at the same time.) Although incredibly shy, he eventually +began to enjoy performing dazzling feats of mathematics before curious +onlookers, who would try to challenge him with tricky questions. + +Scientists, of course, have to be careful in distinguishing true savant" +"skills from simple memorization tricks. Their skills are not just +mathematical—they also extend to incredible musical, artistic, and +mechanical capabilities. Since autistic savants have great difficulty +verbally expressing their mental processes, another avenue is to +investigate individuals who have Asperger’s syndrome, which is a milder +form of autism. Only in 1994 was Asperger’s syndrome recognized as a +distinct psychological condition, so there is very little solid research in +this area. Like autistic individuals, people with Asperger’s have a +difficult time interacting socially with others. However, with proper +training, they can learn enough social skills to hold down a job and +articulate their mental processes. And a fraction of them have +remarkable savant skills. Some scientists believe that many great +scientists had Asperger’s syndrome. This might explain the strange, +reclusive nature of physicists like Isaac Newton and Paul Dirac (one of" +"reclusive nature of physicists like Isaac Newton and Paul Dirac (one of +the founders of the quantum theory). Newton, in particular, was +pathologically incapable of small talk." +"I had the pleasure of interviewing one such individual, Daniel +Tammet, who has written a best seller, Bom on a Blue Day. Almost alone +among these remarkable savants, he is able to articulate his thoughts in +books, on the radio, and in TV interviews. For someone who had such +difficulty relating to others as a child, he now has a superb grasp of +communication skills. + +Daniel has the distinction of setting a world record for memorizing pi, +a fundamental number in geometry. He was able to memorize it to +22,514 decimal places. I asked him how he prepared for such a +herculean feat. Daniel told me that he associates a color or texture with +every number. Then I asked him the key question: If every digit has a +color or texture, then how does he remember tens of thousands of them? +Sadly, at that point he said he doesn’t know. It just comes to him. +Numbers have been his life ever since he was a child, and hence they +simply appear in his mind. His mind is a constant mixture of numbers +and colors." +"ASPERGER’S AND SILICON VALLEY + +So far, this discussion may seem abstract, without any direct bearing on + + our daily lives. But the impact of people with mild autism and Asperger’s +may be more widespread than previously thought, especially in certain +high-tech fields. + +In the hit television series The Big Bang Theory, we follow the antics of +several young scientists, mainly nerdy physicists, in their awkward quest +for female companionship. In every episode, there is a hilarious incident +that reveals how clueless and pathetic they are in this endeavor." +"There is a tacit assumption running through the series that their +intellectual brilliance is matched only by their geekiness. And +anecdotally, people have noticed that among the high-tech gurus in +Silicon Valley, a higher percentage than normal seem to lack some social +skills. (There is a saying among women scientists who attend highly +specialized engineering universities, where the girl-to-guy ratio is +decidedly in their favor: “The odds are good, but the goods are odd.”) + +Scientists set out to investigate this suspicion. The hypothesis is that +people with Asperger’s and other mild forms of autism have mental skills +ideally suited for certain fields, like the information technology industry. +Scientists at University College London examined sixteen people who +were diagnosed with a mild form of autism and compared them with +sixteen normal individuals. Both groups were shown slides containing +random numbers and letters arranged in increasingly complex patterns." +"Their results showed that people with autism had a superior ability to +focus on the task. In fact, as the tasks became harder, the gap between +the intellectual skills of both groups began to widen, with the autistic +individuals performing significantly better than the control group. (The +test, however, also showed that these individuals were more easily +distracted by outside noises and blinking lights than the control group.) + +Dr. Nilli Lavie says, “Our study confirms our hypothesis that people +with autism have higher perceptual capacity compared to the typical +population.... People with autism are able to perceive significantly more +information than the typical adult.” + +This certainly does not prove that all people who are intellectually +brilliant have some form of Asperger’s. But it does indicate that fields +requiring the ability to focus intellectually might have a higher +proportion of people with Asperger’s. + +BRAIN SCANS OF SAVANTS" +"BRAIN SCANS OF SAVANTS + + The subject of savants has always been shrouded in hearsay and amazing +anecdotal stories. But recently, the entire field has been turned upside +down with the development of MRI and other brain scans. + +Kim Peek’s brain, for example, was unusual. MRI scans show that it +lacked the corpus callosum connecting the left and right brain, which is +probably why he could read two pages at the same time. His poor motor +skills were reflected in a deformed cerebellum, the area that controls +balance. Unfortunately, MRI scans could not reveal the exact origin of +his extraordinary abilities and photographic memory. But in general, +brain scans have shown that many suffering from acquired savant +syndrome have experienced damage to their left brain." +"In particular, interest has focused on the left anterior temporal and +orbitofrontal cortices. Some believe that perhaps all savant skills +(autistic, acquired, and Asperger’s) arise from damage to this very +specific spot in the left temporal lobe. This area can act like a “censor” +that periodically flushes out irrelevant memories. But after damage +occurs to the left hemisphere, the right hemisphere starts to take over. +The right brain is much more precise than the left brain, which often +distorts reality and confabulates. In fact, it is believed that the right +brain must work extra hard because of damage to the left brain, and +hence savant skills develop as a consequence. For example, the right +brain is much more artistic than the left brain. Normally, the left brain +restricts this talent and holds it in check. But if the left brain is injured in +a certain way, it may unleash the artistic abilities latent in the right +brain, causing an explosion of artistic talent. So the key to unleashing" +"brain, causing an explosion of artistic talent. So the key to unleashing +savant capabilities might be to dampen the left brain so that it can no +longer restrain the natural talents of the right brain. This is sometimes +referred to as “left brain injury, right brain compensation.”" +"In 1998, Dr. Bruce Miller of the University of California at San +Francisco performed a series of studies that seem to back this idea up. +He and coworkers studied five normal individuals who began to show +signs of frontotemporal dementia (FTD). As their dementia started to +progress, savant abilities gradually began to emerge. As their dementia +got worse, several of these individuals began to exhibit even more +extraordinary artistic ability, although none had shown gifts in this area + +before. Moreover, the abilities they exhibited were typical of savant +behavior. Their abilities were visual, not auditory, and their artworks, +remarkable as they were, were just copies lacking any original, abstract, +or symbolic qualities. (One patient actually got better during the study. +But her emerging savant skills were also reduced as a consequence. This +suggests a close relationship between emerging disorders of the left +temporal lobe and emerging savant skills.)" +"Dr. Miller’s analysis seemed to show that degeneration of the left +anterior temporal and orbitofrontal cortices probably decreased +inhibition of the visual systems in the right hemisphere, thereby +increasing artistic abilities. Again, damaging the left hemisphere in a +particular location forced the right hemisphere to take over and develop." +"In addition to the savants, MRI scans have also been done on people +with hyperthymestic syndrome, who also have photographic memories. +These people do not suffer from autism and mental disorders, but they +share some of their skills. In the entire United States, there are only four +documented cases of true photographic memory. One of them is Jill +Price, a school administrator in Los Angeles. She can recall precisely +what she was doing on any particular day going back decades. But she +complains that she finds it difficult to erase certain thoughts. Indeed, her +brain seems to be “stuck on autopilot.” She compares her memory to +watching the world through a split screen, in which the past and present +are constantly competing for her attention." +"Since 2000, scientists at the University of California at Irvine have +scanned her brain, and they’ve found it to be unusual. Several regions +were larger than normal, such as the caudate nuclei (which is involved +with forming habits) and the temporal lobe (which stores facts and +figures). It is theorized that these two areas work in tandem to create her +photographic memory. Her brain is therefore different from the brains of +savants who suffer an injury or damage to their left temporal lobe. The +reason is unknown, but it points to another path by which one may +obtain these fantastic mental abilities. + +CAN WE BECOME SAVANTS? + +All this raises the intriguing possibility that one might be able to + +deliberately deactivate parts of the left brain and thereby increase the +activity of the right brain, forcing it to acquire savant capabilities." +"We recall that transcranial magnetic stimulation, or TMS, allows one +to effectively silence parts of the brain. If so, then why can’t we silence +this part of the left anterior temporal and orbitofrontal cortices using the +TMS and turn on a savantlike genius at will? + +This idea has actually been tried. Dr. Allan Snyder of the University of +Sydney, Australia, made headlines a few years ago when he claimed +that, by applying the TMS to a certain part of the left brain, his subjects +could suddenly perform savantlike feats. By directing low-frequency +magnetic waves into the left hemisphere, one can in principle turn off" +"this dominant region of the brain so that the right hemisphere takes +over. Dr. Synder and his colleagues did an experiment with eleven male +volunteers. They applied the TMS to the subjects’ left frontotemporal +region while the subjects were performing tests involving reading and +drawing. This did not produce savant skills among the subjects, but two +of them had significant improvements in their ability to proofread words +and recognize duplicated words. In another experiment, Dr. R. L. Young +and his colleagues gave a battery of psychological tests to seventeen +individuals. The tests were specifically designed to test for savant skills. +(Tests of this sort analyze a person’s ability to memorize facts, +manipulate numbers and dates, create artwork, or perform music.) Five +of the subjects reported improvement in savantlike skills after treatment +with TMS." +"Dr. Michael Sweeney has observed, “When applied to the prefrontal +lobes, TMS has been shown to enhance the speed and agility of cognitive +processing. The TMS bursts are like a localized jolt of caffeine, but +nobody knows for sure how the magnets actually do their work.” These +experiments hint, but by no means prove, that silencing a part of the left +frontotemporal region could initiate some enhanced skills. These skills +are a far cry from savant abilities, and we should also be careful to point +out that other groups have looked into these experiments, and the results +have been inconclusive. More experimental work must be done, so it is +still too early to render a final judgment one way or the other. + +TMS probes are the easiest and most convenient instrument to use for +this purpose, since they can selectively silence various parts of the brain +at will without relying on brain damage and traumatic accidents. But it" +"should also be noted that TMS probes are still crude, silencing millions +of neurons at a time. Magnetic fields, unlike electrical probes, are not +precise but spread out over several centimeters. We know that the left +anterior temporal and orbitofrontal cortices are damaged in savants and +likely responsible, at least in some part, for their unique abilities, but +perhaps the specific area that must be dampened is an even smaller +subregion. So each jolt of TMS might inadvertently deactivate some of +the areas that need to remain intact in order to produce savantlike skills." +"In the future, with TMS probes we might be able to narrow down the +region of the brain involved with eliciting savant skills. Once this region +is identified, the next step would be to use highly accurate electrical +probes, like those used in deep brain stimulation, to dampen these areas +even more precisely. Then, with the push of a button, it might be +possible to use these probes to silence this tiny portion of the brain in +order to bring out savantlike skills. + + FORGETTING TO FORGET AND PHOTOGRAPHIC MEMORY + +Although savant skills may be initiated by some sort of injury to the left +brain (leading to right brain compensation), this still does not explain +precisely how the right brain can perform these miraculous feats of +memory. By what neural mechanism does photographic memory +emerge? The answer to this question may determine whether we can +become savants." +"Until recently, it was thought that photographic memory was due to +the special ability of certain brains to remember. If so, then it might be +difficult for the average person to learn these memory skills, since only +exceptional brains are capable of them. But in 2012, a new study showed +that precisely the opposite may be true. + +The key to photographic memory may not be the ability of remarkable +brains to learn; on the contrary, it may be their inability to forget. If this +is true, then perhaps photographic memory is not such a mysterious +thing after all. + +The new study was done by scientists at the Scripps Research Institute +in Florida who were working with fruit flies. They found an interesting +way in which these fruit flies learn, which may overturn a cherished idea + +of how memories are formed and forgotten. The fruit flies were exposed +to different smells and were given positive reinforcement (with food) or +negative reinforcement (with electric shocks)." +"The scientists knew that the neurotransmitter dopamine was important +to forming memories. To their surprise, they found that dopamine +actively regulates both the formation and the forgetting of new +memories. In the process of creating new memories, the dCAl receptor +was activated. By contrast, forgetting was initiated by the activation of +the DAMB receptor. + +Previously, it was thought that forgetting might be simply the +degradation of memories with time, which happens passively by itself. +This new study shows that forgetting is an active process, requiring +intervention by dopamine. + +To prove their point, they showed that by interfering with the action +of the dCAl and DAMB receptors, they could, at will, increase or +decrease the ability of fruit flies to remember and forget. A mutation in +the dCAl receptor, for example, impaired the ability of the fruit flies to +remember. A mutation in the DAMB receptor decreased their ability to +forget." +"The researchers speculate that this effect, in turn, may be partially +responsible for savants’ skills. Perhaps there is a deficiency in their +ability to forget. One of the graduate students involved in the study, +Jacob Berry, says, “Savants have a high capacity for memory. But maybe +it isn’t memory that gives them this capacity; maybe they have a bad +forgetting mechanism. This might also be the strategy for developing +drugs to promote cognition and memory—what about drugs that inhibit +forgetting as a cognitive enhancers?” + +Assuming that this result holds up in human experiments as well, it +could encourage scientists to develop new drugs and neurotransmitters +that are able to dampen the forgetting process. One might thus be able +to selectively turn on photographic memories when needed by +neutralizing the forgetting process. In this way, we wouldn’t have the +continuous overflow of extraneous, useless information, which hinders +the thinking of people with savant syndrome." +"What is also exciting is the possibility that the BRAIN project, which is +being championed by the Obama administration, might be able to +identify the specific pathways involved with acquired savant syndrome. + +Transcranial magnetic fields are still too crude to pin down the handful +of neurons that may be involved. But using nanoprobes and the latest in +scanning technologies, the BRAIN project might be able to isolate the +precise neural pathways that make possible photographic memory and +incredible computational, artistic, and musical skills. Billions of research +dollars will be channeled into identifying the specific neural pathways +involved with mental disease and other afflictions of the brain, and the +secret of savant skills may be revealed in the process. Then it might be +possible to take normal individuals and make savants out of them. This +has happened many times in the past because of random accidents. In +the future, this may become a precise medical process. Time will tell." +"So far, the methods analyzed here do not alter the nature of the brain +or the body. The hope is that through the use of magnetic fields, we will +be able to unleash the potential that already exists in our brains but is +latent. The philosophy underlying this idea is that we are all savants +waiting to happen, and it will just take some slight alteration of our +neural circuits to unleash this hidden talent. + +Yet another tactic is to directly alter the brain and the genes, using the +latest in brain science and also genetics. One promising method is to use +stem cells. + +STEM CELLS FOR THE BRAIN" +"STEM CELLS FOR THE BRAIN + + It was dogma for many decades that brain cells do not regenerate. It +seemed impossible that you could repair old, dying brain cells, or grow +new ones to boost your abilities, but all this changed in 1998. That year, +it was discovered that adult stem cells could be found in the +hippocampus, the olfactory bulb, and the caudate nucleus. In brief, stem +cells are the “mother of all cells.” Embryonic stem cells, for instance, can +readily develop into any other cell. Although each of our cells contains +all the genetic material necessary to construct a human being, only +embryonic stem cells have the ability to actually differentiate into any +type of cell in the body. + +Adult stem cells have lost that chameleon-like ability, but they can +still reproduce and replace old, dying cells. As far as memory +enhancement goes, interest has focused on adult stem cells in the" +"hippocampus. It turns out that thousands of new hippocampus cells are +born naturally each day, but most die soon afterward. However, it was +shown that rats that learned new skills retained more of their new cells. +A combination of exercise and mood-elevating chemicals can also boost +the survival rate of new hippocampus cells. It turns out that stress, on +the contrary, accelerates the death of new neurons." +"In 2007, a breakthrough occurred when scientists in Wisconsin and +Japan were able to take ordinary human skin cells, reprogram their +genes, and turn them into stem cells. The hope is that these stem cells, +either found naturally or converted using genetic engineering, can one +day be injected into the brains of Alzheimer’s patients to replace dying +cells. (These new brain cells, because they do not yet have the proper +connections, would not be integrated into the brain’s neural architecture. +This means that a person would have to relearn certain skills to +incorporate these fresh new neurons.) + +Stem cell research is naturally one of the most active areas in brain +research. “Stem cell research and regenerative medicine are in an +extremely exciting phase right now. We are gaining knowledge very fast +and many companies are being formed and are starting clinical trials in +different areas,” says Sweden’s Jonas Frisen of the Karolinska Institute. + +GENETICS OF INTELLIGENCE" +"GENETICS OF INTELLIGENCE + +In addition to stem cells, another avenue of exploration involves +isolating the genes responsible for human intelligence. Biologists note +that we are about 98.5 percent genetically identical to a chimpanzee, yet + + we live twice as long and have exploded in intellectual skills in the past +six million years. So among a handful of genes there must be the ones +responsible for giving us the human brain. Within a few years, scientists +will have a complete map of all these genetic differences, and the secret +to human longevity and enhanced intelligence may be found within this +tiny set. Scientists have focused on a few genes that possibly drove the +evolution of the human brain. + +So perhaps the clue to revealing the secret of intelligence lies in our +understanding of our apelike ancestors. This raises another question: Can +this research make possible the Planet of the Apes ?" +"In this long-running series of movies, a nuclear war destroys modern +civilization. Humanity is reduced to barbarism, but the radiation +somehow accelerates the evolution of the other primates, so that they +become the dominant species on the planet. They create an advanced +civilization, while humans are reduced to scruffy, smelly savages +roaming half naked in the forest. At best, humans become zoo animals. +The tables have turned on the humans, so the apes gawk at us outside +the bars of our cages." +"In the latest installment, The Rise of the Planet of the Apes, scientists are +looking for a cure for Alzheimer’s disease. Along the way, they stumble +on a virus that has the unintended consequence of increasing a +chimpanzee’s intelligence. Unfortunately, one of these enhanced apes is +treated cruelly when placed in a shelter for primates. Using his increased +intelligence, the ape breaks free, infects the other lab animals with the +virus to raise their intelligence, and then frees all of them from their +cages. Soon a caravan of shouting, intelligent apes runs amok on the +Golden Gate Bridge, completely overwhelming local and state police. +After a spectacular, harrowing confrontation with the authorities, the +movie ends with the apes peacefully finding refuge in a redwood forest +north of the bridge." +"Is such a scenario realistic? In the short term, no, but it can’t be ruled +out in the future, since scientists in the coming years should be able to +catalog all the genetic changes that created Homo sapiens. But many +more mysteries have to be solved before we have intelligent apes. + +One scientist who has been fascinated not by science fiction, but by +the genetics of what makes us “human,” is Dr. Katherine Pollard, an +expert in a field called “bioinformatics,” which barely existed a decade +ago. In this field of biology, instead of cutting open animals to +understand how they are put together, researchers use the vast power of +computers to mathematically analyze the genes in animals’ bodies. She +has been at the forefront of finding the genes that define the essence of +what separates us from the apes. Back in 2003, as a freshly minted Ph.D. + + from the University of California at Berkeley, she got her chance." +"from the University of California at Berkeley, she got her chance. + +“I jumped at the opportunity to join the international team that was +identifying the sequence of DNA bases, or ‘letters,’ in the genome of the +common chimpanzee,” she recalled. Her goal was clear. She knew that +only fifteen million base pairs, or “letters,” that make up our genome + +(out of three billion base pairs) separate us from the chimps, our closest +genetic neighbor. (Each “letter” in our genetic code refers to a nucleic +acid, of which there are four, labeled A,T,C, and G. So our genome +consists of three billion letters, arranged like ATTCCAGGG....) + +“I was determined to find them,” she wrote." +"“I was determined to find them,” she wrote. + +Isolating these genes could have enormous implications for our future. +Once we know the genes that gave rise to Homo sapiens, it becomes +possible to determine how humans evolved. The secret of intelligence +might lie in these genes. It might even be possible to accelerate the path +taken by evolution and even enhance our intelligence. But even fifteen +million base pairs is a huge number to analyze. How can you find a +handful of genetic needles out of this genetic haystack?" +"Dr. Pollard knew that most of our genome is made of “junk DNA” that +does not contain any genes and was largely unaffected by evolution. This +junk DNA slowly mutates at a known rate (roughly 1 percent of it +changes over four million years). Since we differ from the chimps in our +DNA by 1.5 percent, this means that we probably separated from the +chimpanzees about six million years ago. Hence there is a “molecular +clock” in each of our cells. And since evolution accelerates this mutation +rate, analyzing where this acceleration took place allows you to tell +which genes are driving evolution. + +Dr. Pollard reasoned that if she could write a computer program that +could find where most of these accelerated changes are located in our +genome, she could isolate precisely the genes that gave birth to Homo +sapiens. After months of hard work and debugging, she finally placed her +program into the giant computers located at the University of California +at Santa Cruz. Anxiously she awaited the results." +"When the computer printout finally arrived, it showed what she was +looking for: there are 201 regions of our genome showing accelerated +change. But the first one on her list caught her attention. + +“With my mentor David Haussler leaning over my shoulder, I looked +at the top hit, a stretch of 118 bases that together became known as +human accelerated region 1 (HAR1),” she recalled. + + She was ecstatic. Bingo! + +“We had hit the jackpot,” she would write. It was a dream come true. + +She was staring at an area of our genome containing only 118 base +pairs, with the largest divergence of mutations separating us from the + +apes. Of these base pairs, only eighteen mutations were altered since we +became human. Her remarkable discovery showed that a small handful +of mutations could be responsible for raising us from the swamp of our +genetic past." +"Next she and her colleagues tried to decipher the precise nature of this +mysterious cluster called HAR1. They found that HAR1 was remarkably +stable across millions of years of evolution. Primates separated from +chickens about three hundred million years ago, yet only two base pairs +differ between chimps and chickens. So HAR1 was virtually unchanged +for several hundred million years, with only two changes, in the letters G +and C. Yet in just six million years, HAR1 mutated eighteen times, +representing a huge acceleration in our evolution." +"But what was more intriguing was the role HAR1 played in controlling +the overall layout of the cerebral cortex, which is famous for its wrinkled +appearance. A defect in the HAR1 region causes a disorder called +“lissencephaly,” or “smooth brain,” causing the cortex to fold +incorrectly. (Defects in this region are also linked to schizophrenia.) +Besides the large size of our cerebral cortex, one of its main +characteristics is that it is highly wrinkled and convoluted, vastly +increasing its surface area and hence its computational power. Dr. +Pollard’s work showed that changing just eighteen letters in our genome +was partially responsible for one of the major, defining genetic changes +in human history, vastly increasing our intelligence. (Recall that the +brain of Carl Friedrich Gauss, one of the greatest mathematicians in +history, was preserved after his death and showed unusual wrinkling.)" +"Dr. Pollard’s list went even further and identified a few hundred other +areas that also showed accelerated change, some of which were already +known. FOX2, for example, is crucial for the development of speech, +another key characteristic of humans. (Individuals with a defective FOX2 +gene have difficulty making the facial movements necessary for speech.) +Another region called HAR2 gives our fingers the dexterity required to +manipulate delicate tools. + +Furthermore, since the genome of the Neanderthal has been +sequenced, it is possible to compare our genetic makeup with a species +even closer to us than the chimpanzees. (When analyzing the FOX2 gene +in Neanderthals, scientists found that we shared the same gene with + + them. This means that there is a possibility that the Neanderthal could + +vocalize and create speech, as we do.)" +"vocalize and create speech, as we do.) + +Another crucial gene is called ASPM, which is thought to be +responsible for the explosive growth of our brain capacity. Some +scientists believe that this and other genes may reveal why humans +became intelligent but the apes did not. (People with a defective version +of the ASPM gene often suffer from microcephaly, a severe form of +mental retardation, because they have a tiny skull, about the size of one +of our ancestors, Australopithecus.)" +"Scientists have tracked the number of mutations within the ASPM +gene and found that it has mutated about fifteen times in the last five to +six million years, since we separated from the chimpanzee. More recent +mutations in these genes seem to be correlated with milestones in our +evolution. For example, one mutation occurred over one hundred +thousand years ago, when modern humans emerged in Africa, +indistinguishable in appearance from us. And the last mutation was +5,800 years ago, which coincides with the introduction of the written +language and agriculture. + +Because these mutations coincide with periods of rapid growth in +intellect, it is tantalizing to speculate that ASPM is among the handful of +genes responsible for our increased intelligence. If this is true, then +perhaps we can determine whether these genes are still active today, and +whether they will continue to shape human evolution into the future." +"All this research raises a question: Can manipulating a handful of +genes increase our intelligence? + +Quite possibly. + +Scientists are rapidly determining the precise mechanism by which +these genes gave rise to intelligence. In particular, genetic regions and +genes like HAR1 and ASPM could help solve a mystery concerning the +brain. If there are roughly twenty-three thousand genes in your genome, +then how can they possibly control the connections linking one hundred +billion neurons, containing a quadrillion total connections (1 with fifteen +zeros after it)? It seems mathematically impossible. The human genome +is about a trillion times too small to code for all our neural connections. +So our very existence seems to be a mathematical impossibility. + +The answer may be that nature takes numerous shortcuts in creating +the brain. First, many neurons are connected randomly, so that a +detailed blueprint is not necessary, which means that these randomly" +"connected regions organize themselves after a baby is born and starts to +interact with the environment. + +And second, nature also uses modules that repeat themselves over and +over again. Once nature discovers something useful, she often repeats it. +This may explain why only a handful of genetic changes are responsible +for most of our explosive growth in intelligence in the last six million +years. + +Size does matter in this case, then. If we tweak the ASPM and a few +other genes, the brain might become larger and more complex, thereby +making it possible to increase our intelligence. (Increasing our brain size +is not sufficient to do this, since how the brain is organized is also +crucially important. But increasing the gray matter of our brain is a +necessary precondition to increasing our intelligence.) + +APES, GENES, AND GENIUS" +"APES, GENES, AND GENIUS + +Dr. Pollard’s research focused on areas of our genome that we share with +the chimpanzees but that are mutated. It is also possible that there are +areas in our genome found only in humans, independent of the apes. +One such gene was discovered recently, in November 2012. Scientists, +led by a team at the University of Edinburgh, isolated the RIM-941 gene, +which is the only gene ever discovered that is found strictly in Homo +sapiens and not in other primates. Also, geneticists can show that the +gene emerged between one and six million years ago (after the time +when humans and chimpanzees split about six million years ago)." +"Unfortunately, this discovery also set off a huge firestorm in science +newsletters and blogs as misleading headlines blared across the Internet. +Breathless articles appeared claiming that scientists had found a single +gene that could, in principle, make chimpanzees intelligent. The essence +of “humanness” had finally been isolated at the genetic level, the +headlines shouted. + +Reputable scientists soon stepped in and tried to calm things down. In +all likelihood, a series of genes, acting together in complex ways, is +responsible for human intelligence. No single gene can make a chimp +suddenly have human intelligence, they said. + +Although these headlines were highly exaggerated, they did raise a + +serious question: How realistic is Planet of the Apes ?" +"There are a series of complications. If the HAR1 and ASPM genes are +tweaked so that the size and structure of the chimp brain suddenly +expand, then a series of other genes would have to be modified as well. +First, you would have to strengthen the chimp’s neck muscles and +increase its body size to support the larger head. But a large brain would +be useless unless it could control fingers capable of exploiting tools. So +the HAR2 gene would also have to be altered to increase their dexterity. +But since chimps often walk on their hands, another gene would have to +be altered so that the backbone would straighten out and an upright +posture would free up the hands. Intelligence is also useless unless +chimps can communicate with other members of the species. So the +FOX2 gene would also have to be mutated so that humanlike speech +would become possible. And lastly, if you want to create a species of +intelligent apes, you would have to modify the birth canal, since it is not" +"intelligent apes, you would have to modify the birth canal, since it is not +large enough to accommodate the larger skull. You could either perform +caesarians to cut the fetus out or genetically alter the birth canal of the +chimps to accommodate the larger brain." +"After all these necessary genetic adjustments, we are left with a +creature that would look very much like us. In other words, it may be +anatomically impossible to create intelligent apes, as in the movies, +without their also mutating into something closely resembling human +beings. + +Clearly, creating intelligent apes is no simple matter, then. The +intelligent apes we see in Hollywood movies are actually monkey suits +with humans inside, or are computer-generated graphics, so all these +issues are conveniently brushed under the rug. But if scientists could +seriously use gene therapy to create intelligent apes, then they might +closely resemble us, with hands that can use tools, vocal cords that can +create speech, backbones that can support an upright posture, and large +neck muscles to support large heads, as we have." +"All this raises ethical issues as well. Although society may allow +genetic studies of apes, it may not tolerate the manipulation of +intelligent creatures that can feel pain and distress. These creatures, after +all, would be intelligent and articulate enough to complain about their +situation and their fate, and their views would be heard in society. + +Not surprisingly, this area of bioethics is so new that it is totally + +unexplored. The technology is not yet ready, but in the coming decades, +as we identify all the genes and their functions that separate us from the +apes, the treatment of these enhanced animals could become a key +question." +"We can see, therefore, that it is only a matter of time before all the +tiny genetic differences between us and the chimpanzees are carefully +sequenced, analyzed, and interpreted. But this still does not explain a +deeper question: What were the evolutionary forces that gave us this +genetic heritage after we separated from the apes? Why did genes like +ASPM, HAR1, and FOX2 develop in the first place? In other words, +genetics gives us the ability to understand how we became intelligent, +but it does not explain why this happened. + +If we can understand this issue, it might provide clues as to how we +might evolve in the future. This takes us to the heart of the ongoing +debate: What is the origin of intelligence? + +THE ORIGIN OF INTELLIGENCE + +Many theories have been proposed as to why humans developed greater +intelligence, going all the way back to Charles Darwin." +"According to one theory, the evolution of the human brain probably +took place in stages, with the earliest phase initiated by climate change +in Africa. As the weather cooled, the forests began to recede, forcing our +ancestors onto the open plains and savannahs, where they were exposed +to predators and the elements. To survive in this new, hostile +environment, they were forced to hunt and walk upright, which freed up +their hands and opposable thumbs to use tools. This in turn put a +premium on a larger brain to coordinate tool making. According to this +theory, ancient man did not simply make tools—“tools made man.”" +"Our ancestors did not suddenly pick up tools and become intelligent. It +was the other way around. Those humans who picked up tools could +survive in the grasslands, while those who did not gradually died off. +The humans who then survived and thrived in the grasslands were those +who, through mutations, became increasingly adept at tool making, +which required an increasingly larger brain. + +Another theory places a premium on our social, collective nature." +"Another theory places a premium on our social, collective nature. + +Humans can easily coordinate the behavior of over a hundred other +individuals involved in hunting, farming, warring, and building, groups +that are much larger than those found in other primates, which gave +humans an advantage over other animals. It takes a larger brain, +according to this theory, to be able to assess and control the behavior of +so many individuals. (The flip side of this theory is that it took a larger +brain to scheme, plot, deceive, and manipulate other intelligent beings +in your tribe. Individuals who could understand the motives of others + + and then exploit them would have an advantage over those who could +not. This is the Machiavellian theory of intelligence.)" +"Another theory maintains that the development of language, which +came later, helped accelerate the rise of intelligence. With language +comes abstract thought and the ability to plan, organize society, create +maps, etc. Humans have an extensive vocabulary unmatched by any +other animal, with words numbering in the tens of thousands for an +average person. With language, humans could coordinate and focus the +activities of scores of individuals, as well as manipulate abstract +concepts and ideas. Language meant you could manage teams of people +on a hunt, which is a great advantage when pursuing the woolly +mammoth. It meant you could tell others where game was plentiful or +where danger lurked." +"Yet another theory is “sexual selection,” the idea that females prefer to +mate with intelligent males. In the animal kingdom, such as in a wolf +pack, the alpha male holds the pack together by brute force. Any +challenger to the alpha male has to be soundly beaten back by tooth and +claw. But millions of years ago, as humans became gradually more +intelligent, strength alone could not keep the tribe together. Anyone +with cunning and intelligence could ambush, lie or cheat, or form +factions within the tribe to take down the alpha male. Hence the new +generation of alpha males would not necessarily be the strongest. Over +time, the leader would become the most intelligent and cunning. This is +probably the reason why females choose smart males (not necessarily +nerdy smart, but “quarterback smart”). Sexual selection in turn +accelerated our evolution to become intelligent. So in this case the +engine that drove the expansion of our brain would be females who" +"engine that drove the expansion of our brain would be females who +chose men who could strategize, become leaders of the tribe, and outwit +other males, which requires a large brain." +"These are just a few of the theories about the origin of intelligence, +and each has its pros and cons. The common theme seems to be the +ability to simulate the future. For example, the purpose of the leader is +to choose the correct path for the tribe in the future. This means any +leader has to understand the intentions of others in order to plan +strategy for the future. Hence simulating the future was perhaps one of +the driving forces behind the evolution of our large brain and +intelligence. And the person who can best simulate the future is the one +who can plot, scheme, read the minds of many of his fellow tribesmen, +and win the arms race with his fellow man. + +Similarly, language allows you to simulate the future. Animals possess +a rudimentary language, but it is mainly in the present tense. Their +language may warn them of an immediate threat, such as a predator +hiding among the trees. However, animal language apparently has no" +"future or past tense. Animals do not conjugate their verbs. So perhaps +the ability to express the past and future tense was a key breakthrough +in the development of intelligence. + +Dr. Daniel Gilbert, a psychologist at Harvard, writes, “For the first few +hundred million years after their initial appearance on our planet, our +brains were stuck in the permanent present, and most brains still are +today. But not yours and not mine, because two or three million years +ago our ancestors began a great escape from the here and now....” + +THE FUTURE OF EVOLUTION + +So far, we have seen that there are intriguing results indicating that one +can increase one’s memory and intelligence, largely by making the brain +more efficient and maximizing its natural capacity. A variety of methods +are being studied, such as certain drugs, genes, or devices (TES, for +example) that might increase the capabilities of our neurons." +"So the concept of altering the brain size and capacity of the apes is a +distinct, though difficult, possibility. Gene therapy on this scale is still +many decades away. But this raises another difficult question: How far +can this go? Can one extend the intelligence of an organism indefinitely? +Or is there a limit to brain modification imposed by the laws of physics? + +Surprisingly, the answer is yes. The laws of physics put an upper limit + +to what can be done with genetic modification of the human brain, +given certain restraints. To see this limit, it is instructive to first examine +whether evolution is still increasing human intelligence, and then what +can be done to accelerate this natural process." +"In popular culture, there is the notion that evolution will give us big +brains and small, hairless bodies in the future. Likewise, aliens from +space, because they are supposed to possess a superior level of +intelligence, are often portrayed in this fashion. Go to any novelty shop +and you will see the same extraterrestrial face, with big bug eyes, a huge +head, and green skin. + +Actually, there are indications that gross human evolution (i.e., our +basic body shape and intelligence) has largely come to a halt. There are +several factors supporting this. First of all, since we are bipedal +mammals who walk upright, there are limitations to the maximum size +of an infant’s skull that can pass through the birth canal. Second, the rise +of modern technology has removed many of the harsh evolutionary +pressures faced by our ancestors." +"However, evolution on a genetic and molecular basis continues +unabated. Although it’s difficult to see with the naked eye, there is +evidence that human biochemistry has changed to adjust to +environmental challenges, such as combating malaria in tropical areas. +Also, humans recently evolved enzymes to digest lactose sugar as we +learned to domesticate cows and drink milk. Mutations have occurred as +humans adjusted to a diet created by the agricultural revolution. +Moreover, people still choose to mate with others who are healthy and +fit, and so evolution continues to eliminate unsuitable genes at this level. +None of these mutations, however, has changed our basic body plan or +increased our brain size. (Modern technology is also influencing our +evolution to some degree. For example, there is no longer any selection +pressure on nearsighted people, since anyone today can be outfitted with +glasses or contact lenses.) + +PHYSICS OF THE BRAIN" +"PHYSICS OF THE BRAIN + +So from an evolutionary and biological point of view, evolution is no +longer selecting for more intelligent people, at least not as rapidly as it + +did thousands of years ago. + +There are also indications from the laws of physics that we have +reached the maximum natural limit of intelligence, so that any +enhancement of our intelligence would have to come from external +means. Physicists who have studied the neurology of the brain conclude +that there are trade-offs preventing us from getting much smarter. Every +time we envision a brain that is larger, or denser, or more complex, we +bump up against these negative trade-offs." +"The first principle of physics that we can apply to the brain is the +conservation of matter and energy; that is, the law stating that the total +amount of matter and energy in a system remains constant. In particular, +in order to carry out its incredible feats of mental gymnastics, the brain +has to conserve energy, and hence it takes many shortcuts. As we saw in +Chapter 1, what we see with our eyes is actually cobbled together using +energy-saving tricks. It would take too much time and energy for a +thoughtful analysis of every crisis, so the brain saves energy by making +snap judgments in the form of emotions. Forgetting is an alternative way +of saving energy. The conscious brain has access to only a tiny portion of +the memories that have an impact on the brain. + +So the question is: Would increased brain size or density of neurons +give us more intelligence?" +"So the question is: Would increased brain size or density of neurons +give us more intelligence? + + Probably not. “Cortical gray matter neurons are working with axons +that are pretty close to the physical limit,” says Dr. Simon Laughlin of +Cambridge University. There are several ways in which one can increase +the intelligence of the brain using the laws of physics, but each has its +own problems: + +• One can increase brain size and extend the length of neurons. The +problem here is that the brain now consumes more energy. This +generates more heat in the process, which is detrimental to our +survival. If the brain uses up more energy, it gets hotter, and tissue +damage results if the body temperature becomes too high. (The +chemical reactions of the human body and our metabolism require +temperatures to be in a precise range.) Also, longer neurons means +that it takes longer for signals to go across the brain, which slows +down the thinking process." +"• One can pack more neurons into the same space by making them + +thinner. But if neurons become thinner and thinner, the complex +chemical/electrical reactions that must take place inside the axons +fail, and eventually they begin to misfire more easily. Douglas Fox, +writing in Scientific American, says, “You might call it the mother of +all limitations: the proteins that neurons use to generate electrical +pulses, called ion channels, are inherently unstable.” + +• One can increase the speed of the signal by making the neurons +thicker. But this also increases energy consumption and generates +more heat. It also increases the size of the brain, which increases the +time it takes for the signals to reach their destination. + +• One can add more connections between neurons. But this again +increases energy consumption and heat generation, making the +brain larger and slower in the process." +"So each time we tinker with the brain, we are checkmated. The laws +of physics seem to indicate that we have maxed out the intelligence that +we humans can attain in this way. Unless we can suddenly increase the +size of our skulls or the very nature of neurons in our brains, it seems we +are at the maximum level of intelligence. If we are to increase our +intelligence, it has to be done by making our brains more efficient (via +drugs, genes, and possibly TES-type machines). + +PARTING THOUGHTS + +In summary, it may be possible in the coming decades to use a" +"PARTING THOUGHTS + +In summary, it may be possible in the coming decades to use a + + combination of gene therapy, drugs, and magnetic devices to increase +our intelligence. There are several avenues of exploration that are +revealing the secrets of intelligence and how it may be modified or +enhanced. But what would it do to society, though, if we could enhance +our intelligence and get a “brain boost”? Ethicists have seriously +contemplated this question, since the basic science is growing so rapidly. +The big fear is that society may bifurcate, with only the rich and +powerful having access to this technology, which they could use to +further solidify their exalted position in society. Meanwhile, the poor +won’t have access to additional brain power, making it more difficult to +move up in society." +"This is certainly a valid concern, but it flies in the face of the history +of technology. Many of the technologies of the past were indeed initially +the province of the rich and powerful, but eventually mass production, +competition, better transportation, and improvements in technology +drove down the costs, so the average person could afford them. (For +example, we take for granted that we eat foods for breakfast that the +king of England could not have procured a century ago. Technology has +made it possible to purchase delicacies from around the world at any +supermarket that would be the envy of the aristocrats of the Victorian +era.) So if it becomes possible to increase our intelligence, the price of +this technology will gradually fall. Technology is never the monopoly of +the privileged rich. Sooner or later ingenuity, hard work, and simple +market forces will drive down its cost." +"There is also the fear that the human race will split into those who +want their intelligence to be boosted and those who prefer to remain the +same, resulting in the nightmare of having a class of super-intelligent +brahmins lord over the masses of the less gifted. + +But again, perhaps the fear of boosting intelligence has been +exaggerated. The average person has absolutely no interest in being able +to solve the complex tensor equations for a black hole. The average +person sees nothing to gain by mastering the mathematics of +hyperspatial dimensions or the physics of the quantum theory. On the +contrary, the average person may find such activities rather boring and +useless. So most of us are not going to become mathematical geniuses if +given the opportunity, because it is not in our character, and we see +nothing to gain from it." +"Keep in mind that society already has a class of accomplished +mathematicians and physicists, and they are paid significantly less than +ordinary businessmen and wield much less power than average +politicians. Being super smart does not guarantee financial success in +life. In fact, being super smart may actually pigeonhole you in the lower +rungs of a society that values athletes, movie stars, comedians, and + + entertainers more. + +No one ever got rich doing relativity. + +Also, a lot depends on precisely which traits are enhanced. There are +other forms of intelligence besides using mathematics. (Some argue that +intelligence must include artistic genius as well. In this case, one can + +conceivably use this talent to make a comfortable living.)" +"conceivably use this talent to make a comfortable living.) + +Anxious parents of high school children may want to boost the IQ of +their kids as they prepare for standardized exams. But IQ, as we have +seen, does not necessarily correspond to success in life. Likewise, people +may want to enhance their memory, but, as we have seen with savants, +having a photographic memory can be a blessing as well as a curse. And +in both cases, enhancement is unlikely to contribute to a society splitting +in two. + +Society as a whole, however, may benefit from this technology. +Workers with an enhanced intelligence would be better prepared to face +an ever-changing job market. Retraining workers for the jobs of the +future would be less of a drain on society. Furthermore, the public will +be able to make informed decisions about major technological issues of +the future (e.g., climate change, nuclear energy, space exploration) +because they will grasp these complex issues better." +"Also, this technology may help even out the playing field. Children +today who go to exclusive private schools and have personal tutors are +better prepared for the job market because they have more opportunities +to master difficult materials. But if everyone has had their intelligence +enhanced, the fault lines within society will be evened out. Then how far +someone goes in life would be more related to their drive, ambition, +imagination, and resourcefulness rather than to being born with a silver +spoon in their mouth. + +In addition, raising our intelligence may help speed up technological +innovation. Increased intelligence would mean a greater ability to +simulate the future, which would be invaluable in making scientific +discoveries. Often, science stagnates in certain areas because of a lack of +fresh new ideas to stimulate new avenues of research. Having an ability +to simulate different possible futures would vastly increase the rate of +scientific breakthroughs." +"These scientific discoveries, in turn, could generate new industries, +which could enrich all of society, creating new markets, new jobs, and +new opportunities. History is full of technological breakthroughs +creating entirely new industries that benefited not just the few, but all of + + society (think of the transistor and the laser, which today form the +foundation of the world economy). + +However, in science fiction, there is the recurring theme of the super + +criminal, who uses his superior brain power to embark on a crime spree +and thwart the superhero. Every Superman has his Lex Luthor, every +Spider-Man has his Green Goblin. Although it is certainly possible that a +criminal mind will use a brain booster to create super weapons and plan +the crime of the century, realize that members of the police force can +also have their intelligence boosted to outwit the evil mastermind. So +super criminals are dangerous only if they are the only ones in +possession of enhanced intelligence." +"So far, we have examined the possibility that we can enhance or alter +our mental capabilities via telepathy, telekinesis, uploading memories, +or brain boosts. Such enhancement basically means modifying and +augmenting the mental capabilities of our consciousness. This tacitly +assumes that our normal consciousness is the only one, but I’d like to +explore whether there are different forms of consciousness. If so, there +could be other ways of thinking that lead to totally different outcomes +and consequences. Within our own thoughts, there are altered states of +consciousness, such as dreams, drug-induced hallucinations, and mental +illness. There is also nonhuman consciousness, the consciousness of +robots, and even that of aliens from outer space. We have to give up the +chauvinistic notion that our human consciousness is the only one. There +is more than one way to create a model of our world, and more than one +way to simulate its future." +"Dreams, for example, are one of the most ancient forms of +consciousness and were studied by the ancients, yet very little progress +has been made in understanding them until recently. Perhaps dreams are +not silly, random events spliced together by the sleeping brain but +phenomena that may give insight into the meaning of consciousness. +Dreams may be a key to understanding altered states of consciousness. + +BOOK III ALTEHED CONSCIOUSNESS + +The future belongs to those who believe in the beauty of their +dreams. + +—ELEANOR ROOSEVELT + + 7 IN YOUR DREAMS + +Dreams can determine destiny." +"—ELEANOR ROOSEVELT + + 7 IN YOUR DREAMS + +Dreams can determine destiny. + +Perhaps the most famous dream in antiquity took place in the year +A.D. 312, when the Roman emperor Constantine engaged in one of the +greatest battles of his life. Faced with a rival army twice the size of his +own, he realized that he probably would die in battle the next day. But +in a dream he had that night, an angel appeared before him bearing the +image of a cross, uttering the fateful words “By this symbol, you shall +conquer.” Immediately he ordered the shields of his troops adorned with +the symbol of the cross." +"History records that he emerged triumphant the next day, cementing +his hold on the Roman Empire. He vowed to repay the blood debt to this +relatively obscure religion, Christianity, that had been persecuted for +centuries by previous Roman emperors and whose adherents were +regularly fed to the lions in the Colosseum. He signed laws that would +eventually pave the way for it to become an official religion of one of +the greatest empires in the world." +"For thousands of years, kings and queens, as well as beggars and +thieves, have all wondered about dreams. The ancients considered +dreams to be omens about the future, so there have been countless +attempts throughout history to interpret them. The Bible records in +Genesis 41 the rise of Joseph, who was able to correctly interpret the +dreams of the Pharaoh of Egypt thousands of years ago. When the +Pharaoh dreamed about seven fat cows, followed by seven lean cows, he +was so disturbed by the imagery that he asked scribes and mystics +throughout the kingdom to find its meaning. All failed to give a +convincing explanation, until Joseph finally interpreted the dream to +mean that Egypt would have seven years of good harvests, followed by +seven years of drought and famine. So, said Joseph, Egypt must begin +stockpiling grain and supplies now, in preparation for the coming years +of want and desperation. When this came to pass, Joseph was considered + +to be a prophet." +"to be a prophet. + +Dreams have long been associated with prophesy, but in more recent +times they’ve also been known to stimulate scientific discovery. The idea +that neurotransmitters could facilitate the movement of information past +a synapse, which forms the foundation of neuroscience, came to +pharmacologist Otto Loewi in a dream. Similarly, in 1865, August +Kekule had a dream about benzene, in which the bonds of carbon atoms +formed a chain that eventually wrapped around and finally formed a + + circle, just like a snake biting its tail. This dream would unlock the +atomic structure of the benzene molecule. He concluded, “Let us learn to +dream!”" +"Dreams have also been interpreted as a window onto our true +thoughts and intentions. The great Renaissance writer and essayist +Michel de Montaigne once wrote, “I believe it to be true that dreams are +the true interpretations of our inclinations, but there is art required to +sort and understand them.” More recently, Sigmund Freud proposed a +theory to explain the origin of dreams. In his signature work, The +Interpretation of Dreams, he claimed that they were manifestations of our +subconscious desires, which were often repressed by the waking mind +but which run wild every night. Dreams were not just the random +figments of our overheated imaginations but could actually uncover +deep secrets and truths about ourselves. “Dreams are the royal road to +the unconscious,” he wrote. Since then, people have amassed huge +encyclopedias that claim to reveal the hidden meaning behind every +disturbing image in terms of Freudian theory." +"Hollywood takes advantage of our continuing fascination with dreams. +A favorite scene in many movies is when the hero experiences a +terrifying dream sequence and then suddenly wakes up from the +nightmare in a cold sweat. In the blockbuster movie Inception, Leonardo +DiCaprio plays a petty thief who steals intimate secrets from the most +unlikely of all places, people’s dreams. With a new invention, he is able +to enter people’s dreams and deceive them into giving up their financial +secrets. Corporations spend millions of dollars protecting industrial +secrets and patents. Billionaires jealously guard their wealth using +elaborate codes. His job is to steal them. The plot quickly escalates as +the characters enter dreams in which a person falls asleep and dreams +again. So these criminals descend deeper and deeper into multiple layers + +of the subconscious." +"of the subconscious. + +But although dreams have always haunted and mystified us, only in +the last decade or so have scientists been able to peel away the mysteries +of dreams. In fact, scientists can now do something once considered +impossible: they are able to take rough photographs and videotapes of +dreams with MRI machines. One day, you may be able to view a video of +the dream you had the previous night and gain insight into your own +subconscious mind. With proper training, you might be able to +consciously control the nature of your dreams. And perhaps, like +DiCaprio’s character, with advanced technology you might even be able +to enter someone else’s dream. + +THE NATURE OF DREAMS" +"THE NATURE OF DREAMS + + As mysterious as they are, dreams are not a superfluous luxury, the +useless ruminations of the idle brain. Dreams, in fact, are essential for +survival. Using brain scans, it is possible to show that certain animals +exhibit dreamlike brain activity. If deprived of dreams, these animals +would often die faster than they would by starvation, because such +deprivation severely disrupts their metabolism. Unfortunately, science +does not know exactly why this is the case. + +Dreaming is an essential feature of our sleep cycle as well. We spend +roughly two hours a night dreaming when we sleep, with each dream +lasting five to twenty minutes. In fact, we spend about six years +dreaming during an average lifetime." +"Dreams are also universal across the human race. Looking across +different cultures, scientists find common themes in dreams. Fifty +thousand dreams were recorded over a forty-year time period by +psychology professor Calvin Hall. He followed this up with one thousand +dream reports from college students. Not surprisingly, he found that +most people dreamed of the same things, such as personal experiences +from the previous days or week. (However, animals apparently dream +differently than we do. In the dolphin, for example, only one hemisphere +at a time sleeps in order to prevent drowning, because they are air- +breathing mammals, not fish. So if they dream, it is probably in only one +hemisphere at a time.)" +"The brain, as we have seen, is not a digital computer, but rather a +neural network of some sort that constantly rewires itself after learning +new tasks. Scientists who work with neural networks noticed something +interesting, though. Often these systems would become saturated after +learning too much, and instead of processing more information they +would enter a “dream” state, whereby random memories would +sometimes drift and join together as the neural networks tried to digest +all the new material. Dreams, then, might reflect “house cleaning,” in +which the brain tries to organize its memories in a more coherent way. +(If this is true, then possibly all neural networks, including all organisms +that can learn, might enter a dream state in order to sort out their +memories. So dreams probably serve a purpose. Some scientists have +speculated that this might imply that robots that learn from experience +might also eventually dream as well.)" +"Neurological studies seem to back up this conclusion. Studies have +shown that retaining memories can be improved by getting sufficient +sleep between the time of activity and a test. Neuroimaging shows that +the areas of the brain that are activated during sleep are the same as +those involved in learning a new task. Dreaming is perhaps useful in + + consolidating this new information. + +Also, some dreams can incorporate events that happened a few hours +earlier, just before sleep. But dreams mostly incorporate memories that +are a few days old. For example, experiments have shown that if you put +rose-colored glasses on a person, it takes a few days before the dreams +become rose-colored as well. + +BRAIN SCANS OF DREAMS" +"BRAIN SCANS OF DREAMS + +Brain scans are now unveiling some of the mystery of dreams. Normally +EEG scans show that the brain is emitting steady electromagnetic waves +while we are awake. However, as we gradually fall asleep, our EEG +signals begin to change frequency. When we finally dream, waves of +electrical energy emanate from the brain stem that surge upward, rising +into the cortical areas of the brain, especially the visual cortex. This +confirms that visual images are an important component of dreams. +Finally, we enter a dream state, and our brain waves are typified by + +rapid eye movements (REM). (Since some mammals also enter REM +sleep, we can infer that they might dream as well.)" +"While the visual areas of the brain are active, other areas involved +with smell, taste, and touch are largely shut down. Almost all the images +and sensations processed by the body are self-generated, originating +from the electromagnetic vibrations from our brain stem, not from +external stimuli. The body is largely isolated from the outside world. +Also, when we dream, we are more or less paralyzed. (Perhaps this +paralysis is to prevent us from physically acting out our dreams, which +could be disastrous. About 6 percent of people suffer from “sleep +paralysis” disorder, in which they wake up from a dream still paralyzed. +Often these individuals wake up frightened and believing that there are +creatures pinning down their chest, arms, and legs. There are paintings +from the Victorian era of women waking up with a terrifying goblin +sitting on their chest glaring down at them. Some psychologists believe +that sleep paralysis could explain the origin of the alien abduction +syndrome.)" +"The hippocampus is active when we dream, suggesting that dreams +draw upon our storehouse of memories. The amygdala and anterior +cingulate are also active, meaning that dreams can be highly emotional, +often involving fear. + +But more revealing are the areas of the brain that are shut down, +including the dorsolateral prefrontal cortex (which is the command + + center of the brain), the orbitofrontal cortex (which can act like a censor +or fact-checker), and the temporoparietal region (which processes +sensory motor signals and spatial awareness)." +"When the dorsolateral prefrontal cortex is shut down, we can’t count +on the rational, planning center of the brain. Instead, we drift aimlessly +in our dreams, with the visual center giving us images without rational +control. The orbitofrontal cortex, or the fact-checker, is also inactive. +Hence dreams are allowed to blissfully evolve without any constraints +from the laws of physics or common sense. And the temporoparietal +lobe, which helps coordinate our sense of where we are located using +signals from our eyes and inner ear, is also shut down, which may +explain our out-of-body experiences while we dream. + +As we have emphasized, human consciousness mainly represents the +brain constantly creating models of the outside world and simulating + +them into the future. If so, then dreams represent an alternate way in +which the future is simulated, one in which the laws of nature and social +interactions are temporarily suspended. + +HOW DO WE DREAM?" +"HOW DO WE DREAM? + +But that leaves open this question: What generates our dreams? One of +the world’s authorities on dreams is Dr. Allan Hobson, a psychiatrist at +Harvard Medical School. He has devoted decades of his life to unveiling +the secrets of dreams. He claims that dreams, especially REM sleep, can +be studied at the neurological level, and that dreams arise when the +brain tries to make sense of the largely random signals emanating from +the brain stem. + +When I interviewed him, he told me that after many decades of +cataloging dreams, he found five basic characteristics: + +1. Intense emotions—this is due to the activation of the amygdala, +causing emotions such as fear. + +2. Illogical content—dreams can rapidly shift from one scene to +another, in defiance of logic. + +3. Apparent sensory impressions—dreams give us false sensations that +are internally generated. + +4. Uncritical acceptance of dream events—we uncritically accept the +illogical nature of the dream." +"5. Difficulty in being remembered—dreams are soon forgotten, within +minutes of waking up. + +Dr. Hobson (with Dr. Robert McCarley) made history by proposing the +first serious challenge to Freud’s theory of dreams, called the “activation +synthesis theory.” In 1977, they proposed the idea that dreams originate +from random neural firings in the brain stem, which travel up to the +cortex, which then tries to make sense of these random signals. + +The key to dreams lies in nodes found in the brain stem, the oldest +part of the brain, which squirts out special chemicals, called adrenergics, +that keep us alert. As we go to sleep, the brain stem activates another + +system, the cholinergic, which emits chemicals that put us in a dream +state." +"system, the cholinergic, which emits chemicals that put us in a dream +state. + +As we dream, cholinergic neurons in the brain stem begin to fire, +setting off erratic pulses of electrical energy called PGO (pontine- +geniculate-occipital) waves. These waves travel up the brain stem into +the visual cortex, stimulating it to create dreams. Cells in the visual +cortex begin to resonate hundreds of times per second in an irregular +fashion, which is perhaps responsible for the sometimes incoherent +nature of dreams. + +This system also emits chemicals that decouple parts of the brain +involved with reason and logic. The lack of checks coming from the +prefrontal and orbitofrontal cortices, along with the brain becoming +extremely sensitive to stray thoughts, may account for the bizarre, +erratic nature of dreams." +"Studies have shown that it is possible to enter the cholinergic state +without sleep. Dr. Edgar Garcia-Rill of the University of Arkansas claims +that meditation, worrying, or being placed in an isolation tank can +induce this cholinergic state. Pilots and drivers facing the monotony of a +blank windshield for many hours may also enter this state. In his +research, he has found that schizophrenics have an unusually large +number of cholinergic neurons in their brain stem, which may explain +some of their hallucinations. + +To make his studies more efficient, Dr. Allan Hobson had his subjects +put on a special nightcap that can automatically record data during a +dream. One sensor connected to the nightcap registers the movements of +a person’s head (because head movements usually occur when dreams +end). Another sensor measures movements of the eyelids (because REM +sleep causes eyelids to move). When his subjects wake up, they +immediately record what they dreamed about, and the information from" +"the nightcap is fed into a computer. + +In this way, Dr. Hobson has accumulated a vast amount of information +about dreams. So what is the meaning of dreams? I asked him. He +dismisses what he calls the “mystique of fortune-cookie dream +interpretation.” He does not see any hidden message from the cosmos in +dreams. + +Instead, he believes that after the PGO waves surge from the brain +stem into the cortical areas, the cortex is trying to make sense of these + +erratic signals and winds up creating a narrative out of them: a dream. + +PHOTOGRAPHING A DREAM" +"erratic signals and winds up creating a narrative out of them: a dream. + +PHOTOGRAPHING A DREAM + +In the past, most scientists avoided the study of dreams, since they are so +subjective and have such a long historical association with mystics and +psychics. But with MRI scans, dreams are now revealing their secrets. In +fact, since the brain centers that control dreaming are nearly identical to +the ones that control vision, it is therefore possible to photograph a +dream. This pioneering work is being done in Kyoto, Japan, by scientists +at the ATR Computational and Neuroscience Laboratories." +"Subjects are first placed in an MRI machine and shown four hundred +black-and-white images, each consisting of a set of dots within a ten-by- +ten-pixel framework. One picture is flashed at a time, and the MRI +records how the brain responds to each collection of pixels. As with +other groups working in this field of BMI, the scientists eventually create +an encyclopedia of images, with each image of pixels corresponding to a +specific MRI pattern. Here the scientists are able to work backward, to +correctly reconstruct self-generated images from MRI brain scans taken +while the subject dreams. + +ATR chief scientist Yukiyasu Kamitani says, “This technology can also +be applied to senses other than vision. In the future, it may also be +possible to read feelings and complicated emotional states.” In fact, any +mental state of the brain might be imaged in this way, including dreams, +as long as a one-to-one map can be made between a certain mental state +and an MRI scan." +"The Kyoto scientists have concentrated on analyzing still photographs +generated by the mind. In Chapter 3, we encountered a similar approach +pioneered by Dr. Jack Gallant, in which the voxels from 3-D MRI scans +of the brain can be used to reconstruct the actual image seen by the eye +with the help of a complex formula. A similar process has allowed Dr. + + Gallant and his team to create a crude video of a dream. When I visited +the laboratory in Berkeley, I talked to a postdoctoral staff member, Dr. +Shinji Nishimoto, who allowed me to watch the video of one of his +dreams, one of the first ever done. I saw a series of faces flickering +across the computer screen, meaning that the subject (in this case Dr." +"Nishimoto himself) was dreaming of people, rather than animals or +objects. This was amazing. Unfortunately, the technology is not yet good +enough to see the precise facial features of the people appearing in his +dream, so the next step is to increase the number of pixels so that more +complex images can be identified. Another advance will be to reproduce +images in color rather than black and white. + +I then asked Dr. Nishimoto the crucial question: How do you know the +video is accurate? How do you know that the machine isn’t just making +things up? He was a bit sheepish when he replied that this was a weak +point in his research. Normally, you have only a few minutes after +waking up to record a dream. After that, most dreams are lost in the fog +of our consciousness, so it is not easy to verify the results." +"Dr. Gallant told me that this research on videotaping dreams was still +a work in progress, and that is why it’s not ready for publication. There +is still a ways to go before we can watch a videotape of last night’s +dream. + +LUCID DREAMS + +Scientists are also investigating a form of dreaming that was once +thought to be a myth: lucid dreaming, or dreaming while you are +conscious. This sounds like a contradiction in terms, but it has been +verified in brain scans. In lucid dreaming, dreamers are aware that they +are dreaming and can consciously control the direction of the dream. +Although science has only recently begun to experiment with lucid +dreaming, there are references to this phenomenon dating back +centuries. In Buddhism, for example, there are books that refer to lucid +dreamers and how to train yourself to become one. Over the centuries, +several people in Europe have written detailed accounts of their lucid +dreams." +"Brain scans of lucid dreamers show that this phenomenon is real; +during REM sleep, their dorsolateral prefrontal cortex, which is usually +dormant when a normal person dreams, is active, indicating that the +person is partially conscious while dreaming. In fact, the more lucid the +dream, the more active the dorsolateral prefrontal cortex. Since the +dorsolateral prefrontal cortex represents the conscious part of the brain, + + the dreamer must be aware while he or she is dreaming." +"the dreamer must be aware while he or she is dreaming. + +Dr. Hobson told me that anyone can learn to do lucid dreaming by +practicing certain techniques. In particular, people who do lucid +dreaming should keep a notebook of dreams. Before going to sleep, they +should remind themselves that they will “wake up” in the middle of the +dream and realize that they are moving in a dream world. It is important +to have this frame of mind before hitting the pillow. Since the body is +largely paralyzed during REM sleep, it is difficult for the dreaming +person to send a signal to the outside world that he has entered a dream, +but Dr. Stephen LaBerge at Stanford University has studied lucid +dreamers (including himself) who can signal the outside world while +dreaming." +"In 2011, for the first time, scientists used MRI and EEG sensors to +measure dream content and even make contact with a dreaming person. +At the Max Planck Institute in Munich and Leipzig, scientists enlisted the +help of lucid dreamers, who were fitted with EEG sensors on their heads +to help the scientists determine the moment they entered REM sleep; +they were then placed in an MRI machine. Before falling asleep, the +dreamers agreed to initiate a set of eye movements and breathing +patterns when dreaming, like a Morse code. They were told that once +they started dreaming, they should clench their right fist and then their +left one for ten seconds. That was the signal that they were dreaming." +"The scientists found that, once the subjects entered their dream state, +the sensorimotor cortex of the brain (responsible for controlling motor +actions like clenching your fists) was activated. The MRI scans could +pick up that the fists were being clenched and which fist was being +clenched first. Then, using another sensor (a near-infrared spectrometer) +they were able to confirm that there was increased brain activity in the +region that controls the planning of movements. + +“Our dreams are therefore not a ‘sleep cinema’ in which we merely +observe an event passively, but involve activity in the regions of the +brain that are relevant to the dream content,” says Michael Czisch, a +group leader at the Max Planck Institute. + +ENTERING A DREAM + +If we can communicate with a dreaming person, then is it also possible +to alter someone’s dream from the outside? Quite possibly. + +First, as we have seen, scientists have already made the initial steps in" +"First, as we have seen, scientists have already made the initial steps in + + videotaping a person’s dream, and in the coming years, it should be +possible to create much more accurate pictures and videos of dreams. +Since scientists have already been able to establish a communication link +between the real world and the lucid dreamer in the fantasy world, then, +in principle, scientists should be able to deliberately alter the course of a +dream. Let’s say that scientists are viewing the video of a dream using an +MRI machine as the dream unfolds in real time. As the person wanders +around the dreamscape, the scientists can tell where he is going and give +directions for him to move in different ways. + +So in the near future, it might be possible to watch a video of a +person’s dream and actually influence its general direction. But in the +movie Inception, Leonardo DiCaprio goes much further. He is able not +only to watch another person’s dream, but also to enter it. Is this +possible?" +"We saw earlier that we are paralyzed when we dream so that we don’t +carry out our dream fantasies, which might be disastrous. However, +when people are sleepwalking, they often have their eyes open (although +their eyes look glazed over). So sleepwalkers live in a hybrid world, part +real and part dreamlike. There are many documented instances of people +walking around their homes, driving cars, cutting wood, and even +committing homicides while in this dream state, where reality and the +fantasy world are mixed. Hence it is possible that physical images that +the eye actually sees can freely interact with the fictitious images that +the brain is concocting during a dream." +"The way to enter someone’s dream, then, might be to have the subject +wear contact lenses that can project images directly onto their retinas. +Already, prototypes of Internet contact lenses are being developed at the +University of Washington in Seattle. So if the observer wanted to enter +the subject’s dream, first he would sit in a studio and have a video +camera film him. His image could then be projected onto the contact +lenses of the dreamer, creating a composite image (the image of the +observer superimposed upon the imaginary image the brain is +manufacturing). + +The observer could actually see this dream world as he wanders + +around the dream, since he, too, would be wearing Internet contact +lenses. The MRI image of the subject’s dream, after it has been +deciphered by computer, would be sent directly into the observer’s +contact lenses." +"Furthermore, you could actually change the direction of the dream +you have entered. As you walk around in the empty studio, you would +see the dream unfold in your contact lens, so you could start to interact + + with the objects and people appearing in the dream. This would be quite +an experience, since the background would change without warning, +images would appear and disappear without reason, and the laws of +physics would be suspended. Anything goes." +"Further into the future, it might even be possible to enter another +person’s dream by directly connecting two sleeping brains. Each brain +would have to be connected to MRI scanners that were connected to a +central computer, which would merge the two dreams into a single one. +The computer would first decipher each person’s MRI scans into a video +image. Then the dream of one person would be sent into the sensory +areas of the other person’s brain, so that the other dreamer’s dream +would merge with the first dreamer’s dream. However, the technology of +videotaping and interpreting dreams would have to become much more +advanced before this could become a possibility." +"But this raises another question: If it’s possible to alter the course of +someone’s dream, is it possible to control not only that person’s dream +but that person’s mind as well? During the Cold War, this became a +serious issue as both the Soviet Union and the United States played a +deadly game, trying to use psychological techniques to control other +people’s wills. + +Minds are simply what brains do. + +—MARVIN MINSKY + +8 CAN THE MIND BE CONTROLLED?" +"Minds are simply what brains do. + +—MARVIN MINSKY + +8 CAN THE MIND BE CONTROLLED? + +A raging bull is released into an empty arena in Cordoba, Spain. For +generations, this ferocious beast has been carefully bred to maximize its +killer instinct. Then a Yale professor calmly enters the same arena. +Rather than donning a tweed jacket, he is dressed like a dashing +matador, wearing a bright golden jacket and waving a red cape defiantly +in front of the bull, egging him on. Instead of running away in terror, the +professor looks calm, confident, and even detached. To a bystander, it +appears as if the professor has gone mad and wants to commit suicide." +"Enraged, the bull locks onto the professor. Suddenly the bull charges, +aiming his deadly horns at him. The professor does not run away in fear. +Instead, he holds a small box in his hand. Then, in front of the cameras, +he presses a button on the box, and the bull stops dead in his tracks. The +professor is so confident of himself that he has risked his life to prove a +point, that he has mastered the art of controlling the mind of a mad bull. + + The Yale professor is Dr. Jose Delgado, who was years ahead of his +time. He pioneered a series of remarkable but unsettling animal +experiments in the 1960s, in which he put electrodes into their brains +with the aim of trying to control their movement. To stop the bull, he +inserted electrodes into the striatum of the basal ganglia at the base of +the brain, which is involved with motor coordination." +"He also did a series of other experiments on monkeys to see if he could +rearrange their social hierarchy with the push of a button. After +implanting electrodes into the caudate nucleus (a region associated with +motor control) of the alpha male within the group, Delgado could reduce +the aggressive tendencies of the leader on command. Without threats of +retaliation, the delta males began to assert themselves, taking over the +territory and privileges normally reserved for the alpha male. The alpha +male, meanwhile, appeared to have lost interest in defending his +territory. + +Then Dr. Delgado pressed another button, and the alpha male + +instantly sprung back to normal, resuming his aggressive behavior and +reestablishing his power as the king of the hill. The delta males +scrambled in fear. + +Dr. Delgado was the first person in history to show that it was possible +to control the minds of animals in this way. The professor became the +puppet master, pulling the strings of living puppets." +"As expected, the scientific community looked at Dr. Delgado’s work +with unease. To make matters worse, he wrote a book in 1969 with the +provocative title Physical Control of the Mind: Toward a Psychocivilized +Society. It raised an unsettling question: If scientists like Dr. Delgado are +pulling the strings, then who controls the puppet master?" +"Dr. Delgado’s work puts into sharp focus the enormous promise and +perils of this technology. In the hands of an unscrupulous dictator, this +technology might be used to deceive and control his unfortunate +subjects. But it can also be used to free millions of people who are +trapped in mental illness, hounded by their hallucinations, or crushed by +their anxieties. (Years later, Dr. Delgado was asked by a journalist why +he initiated these controversial experiments. He said that he wanted to +correct the horrendous abuses being suffered by the mentally ill. They +often underwent radical lobotomies, in which the prefrontal cortex was +scrambled by a knife resembling an ice pick, which was hammered into +the brain above the eye socket. The results were often tragic, and some +of the horrors were exposed in Ken Kesey’s novel One Flew Over the +Cuckoo’s Nest, which was made into a movie with Jack Nicholson. Some" +"patients became calm and relaxed, but many others became zombies: +lethargic, indifferent to pain and feelings, and emotionally vacuous. The +practice was so widespread that in 1949, Antonio Moniz won the Nobel +Prize for perfecting the lobotomy. Ironically, in 1950, the Soviet Union +banned this technology, stating that “it was contrary to the principles of +humanity.” Lobotomies, the Soviet Union charged, turned “an insane +person into an idiot.” In total, it is estimated that forty thousand +lobotomies were performed in the United States alone over two +decades.) + +MIND CONTROL AND THE COLD WAR + +Another reason for the chilly reception of Dr. Delgado’s work was the +political climate of the time. It was the height of the Cold War, with +painful memories of captured U.S. soldiers being paraded in front of +cameras during the Korean War. With blank stares, they would admit +they were on secret spy missions, confess to horrific war crimes, and +denounce U.S. imperialism." +"To make sense of this, the press used the term “brainwashing,” the +idea that the communists had developed secret drugs and techniques to +turn U.S. soldiers into pliable zombies. In this charged political climate, +Frank Sinatra starred in the 1962 Cold War thriller The Manchurian +Candidate, in which he tries to expose a secret communist “sleeper” +agent whose mission is to assassinate the president of the United States. +But there is a twist. The assassin is actually a trusted U.S. war hero, +someone who was captured and then brainwashed by the communists. +Coming from a well-connected family, the agent seems above suspicion +and is almost impossible to stop. The Manchurian Candidate mirrored the +anxieties of many Americans at that time." +"Many of these fears were also stoked by Aldous Huxley’s prophetic +1931 novel Brave New World. In this dystopia, there are large test-tube- +baby factories that produce clones. By selectively depriving oxygen from +these fetuses, it is possible to produce children of different levels of brain +damage. At the top are the alphas, who suffer no brain damage and are +bred to rule society. At the bottom are the epsilons, who suffer +significant brain damage and are used as disposable, obedient workers. +In between are additional levels made up of other workers and the +bureaucracy. The elite then control society by flooding it with mind- +altering drugs, free love, and constant brainwashing. In this way, peace, +tranquility, and harmony are maintained, but the novel asked a +disturbing question that resonates even today: How much of our freedom +and basic humanity do we want to sacrifice in the name of peace and +social order? + + CIA MIND-CONTROL EXPERIMENTS" +"CIA MIND-CONTROL EXPERIMENTS + +The Cold War hysteria eventually reached the highest levels of the CIA. +Convinced that the Soviets were far ahead in the science of brainwashing + +and unorthodox scientific methods, the CIA embarked upon a variety of +classified projects, such as MKULTRA, which began in 1953, to explore +bizarre, fringe ideas. (In 1973, as the Watergate scandal spread panic +throughout the government, CIA director Richard Helms canceled +MKULTRA and hurriedly ordered all documents pertaining to the project +destroyed. However, a cache of twenty thousand documents somehow +survived the purge and were declassified in 1977 under the Freedom of +Information Act, revealing the full scope of this massive effort.)" +"It is now known that, from 1953 to 1973, MULTRA funded 80 +institutions, including 44 universities and colleges, and scores of +hospitals, pharmaceutical companies, and prisons, often experimenting +on unsuspecting people without their permission, in 150 secret +operations. At one point, fully 6 percent of the entire CIA budget went +into MKULTRA. + +Some of these mind-control projects included: + +• developing a “truth serum” so prisoners would spill their secrets + +• erasing memories via a U.S. Navy project called “Subproject 54” + +• using hypnosis and a wide variety of drugs, especially LSD, to +control behavior + +• investigating the use of mind-control drugs against foreign leaders, +e.g., Fidel Castro + +• perfecting a variety of interrogation methods against prisoners + +• developing a knockout drug that was fast working and left no trace + +• altering people’s personality via drugs to make them more pliable" +"• altering people’s personality via drugs to make them more pliable + +Although some scientists questioned the validity of these studies, +others went along willingly. People from a wide range of disciplines +were recruited, including psychics, physicists, and computer scientists, to +investigate a variety of unorthodox projects: experimenting with mind- +altering drugs such as LSD, asking psychics to locate the position of +Soviet submarines patrolling the deep oceans, etc. In one sad incident, a + + U.S. Army scientist was secretly given LSD. According to some reports, +he became so violently disoriented that he committed suicide by +jumping out a window." +"Most of these experiments were justified on the grounds that the +Soviets were already ahead of us in terms of mind control. The U.S. +Senate was briefed in another secret report that the Soviets were +experimenting with beaming microwave radiation directly into the +brains of test subjects. Rather than denouncing the act, the United States +saw “great potential for development into a system for disorienting or +disrupting the behavior pattern of military or diplomatic personnel.” The +U.S. Army even claimed that it might be able to beam entire words and +speeches into the minds of the enemy: “One decoy and deception +concept ... is to remotely create noise in the heads of personnel by +exposing them to low power, pulsed microwaves.... By proper choice of +pulse characteristics, intelligible speech may be created.... Thus, it may +be possible to ‘talk’ to selected adversaries in a fashion that would be +most disturbing to them,” the report said." +"Unfortunately, none of these experiments was peer-reviewed, so +millions of taxpayer dollars were spent on projects like this one, which +most likely violated the laws of physics, since the human brain cannot +receive microwave radiation and, more important, does not have the +ability to decode microwave messages. Dr. Steve Rose, a biologist at the +Open University, has called this far-fetched scheme a “neuro-scientific +impossibility.” + +But for all the millions of dollars spent on these “black projects,” +apparently not a single piece of reliable science emerged. The use of +mind-altering drugs did, in fact, create disorientation and even panic +among the subjects who were tested, but the Pentagon failed to +accomplish the key goal: control of the conscious mind of another +person." +"Also, according to psychologist Robert Jay Lifton, brainwashing by the +communists had little long-term effect. Most of the American troops who +denounced the United States during the Korean War reverted back to +their normal personalities soon after being released. In addition, studies +done on people who have been brainwashed by certain cults also show +that they revert back to their normal personality after leaving the cult. +So it seems that, in the long run, one’s basic personality is not affected +by brainwashing. + +Of course, the military was not the first to experiment with mind +control. In ancient times, sorcerers and seers would claim that giving + + magic potions to captured soldiers would make them talk or turn against +their leaders. One of the earliest of these mind-control methods was +hypnotism. + +YOU ARE GETTING SLEEPY...." +"YOU ARE GETTING SLEEPY.... + +As a child, I remember seeing TV specials devoted to hypnosis. In one +show, a person was placed in a hypnotic trance and told that when he +woke up, he would be a chicken. The audience gasped as he began to +cluck and flap his arms around the stage. As dramatic as this +demonstration was, it’s simply an example of “stage hypnosis.” Books +written by professional magicians and showmen explain that they use +shills planted in the audience, the power of suggestion, and even the +willingness of the victim to play along with the ruse. + +I once hosted a BBC/Discovery TV documentary called Time, and the +subject of long-lost memories came up. Is it possible to evoke such +distant memories through hypnosis? And if it is, can you then impose +your will on another? To test some of these ideas, I had myself +hypnotized for TV." +"BBC hired a skilled professional hypnotist to begin the process. I was +asked to lie down on a bed in a quiet, darkened room. The hypnotist +spoke to me in slow, gentle tones, gradually making me relax. After a +while, he asked me to think back into the past, to perhaps a certain place +or incident that stood out even after all these years. And then he asked +me to reenter that place, reexperiencing its sights, sounds, and smells. +Remarkably, I did begin to see places and people’s faces that I had +forgotten about decades ago. It was like watching a blurred movie that +was slowly coming into focus. But then the recollections stopped. At a +certain point, I could not recapture any more memories. There was +clearly a limit to what hypnosis could do." +"EEG and MRI scans show that during hypnosis the subject has minimal +sensory stimulation in the sensory cortices from the outside. In this way, +hypnosis can allow one to access some memories that are buried, but it +certainly cannot change one’s personality, goals, or wishes. A secret +1966 Pentagon document corroborates this, explaining that hypnotism +cannot be trusted as a military weapon. “It is probably significant that in + +the long history of hypnosis, where the potential application to +intelligence has always been known, there are no reliable accounts of its +effective use by an intelligence service,” it read." +"It should also be noted that brain scans show that hypnotism is not a +new state of consciousness, like dreaming and REM sleep. If we define +human consciousness as the process of continually building models of +the outside world and then simulating how they evolve into the future to +carry out a goal, we see that hypnosis cannot alter this basic process. +Hypnosis can accentuate certain aspects of consciousness and help +retrieve certain memories, but it cannot make you squawk like a chicken +without your permission. + +MIND-ALTERING DRUGS AND TRUTH SERUMS + +One of the goals of MKULTRA was the creation of a truth serum so that +spies and prisoners would reveal their secrets. Although MKULTRA was +canceled in 1973, U.S. Army and CIA interrogation manuals declassified +by the Pentagon in 1996 still recommended the use of truth serums +(although the U.S. Supreme Court ruled that confessions obtained in this +way were “unconstitutionally coerced” and hence inadmissible in court)." +"Anyone who watches Hollywood movies knows that sodium pentathol +is the truth serum of choice used by spies (as in the movies True Lies +with Arnold Schwarzenegger and Meet the Fockers with Robert De Niro). +Sodium pentathol is part of a larger class of barbiturates, sedatives, and +hypnotics that can evade the blood-brain barrier, which prevents most +harmful chemicals in the bloodstream from entering the brain." +"Not surprisingly, most mind-altering drugs, such as alcohol, affect us +powerfully because they can evade this barrier. Sodium pentathol +depresses activity in the prefrontal cortex, so that a person becomes +more relaxed, talkative, and uninhibited. However, this does not mean +that they tell the truth. On the contrary, people under the influence of +sodium pentathol, like those who have imbibed a few too many, are +fully capable of lying. The “secrets” that come spilling out of the mouth +of someone under this drug may be total fabrications, so even the CIA +eventually gave up on drugs like this. + +But this still leaves open the possibility that, one day, a wonder drug" +"But this still leaves open the possibility that, one day, a wonder drug + +might be found that could alter our basic consciousness. This drug would +work by changing the synapses between our nerve fibers by targeting +neurotransmitters that operate in this area, such as dopamine, serotonin, +or acetylcholine. If we think of the synapses as a series of tollbooths +along a superhighway, then certain drugs (such as stimulants like +cocaine) can open the tollbooth and let messages pass by unimpeded. +The sudden rush that drug addicts feel is caused when these tollbooths +are opened all at once, causing an avalanche of signals to flood by. But + + when all the synapses have fired in unison, they cannot fire again until +hours later. It’s as if the tolls have closed, and this causes the sudden +depression one feels after the rush. The body’s desire to reexperience the +sudden rush then causes addiction. + +HOW DRUGS ALTER THE MIND" +"HOW DRUGS ALTER THE MIND + +Although the biochemical basis for mind-altering drugs was not known +when the CIA first conducted its experiments on unsuspecting subjects, +since then the molecular basis of drug addiction has been studied in +detail. Studies in animals demonstrate how powerful drug addiction is: +rats, mice, and primates will, given the chance, take drugs like cocaine, +heroin, and amphetamines until they drop from exhaustion or die from +it." +"To see how widespread this problem has become, consider that by +2007, thirteen million Americans aged twelve or over (or 5 percent of +the entire teen and adult population of the United States) had tried or +become addicted to methamphetamines. Drug addiction not only +destroys entire lives, it also systematically destroys the brain. MRI scans +of the brains of meth addicts show an 11 percent reduction in the size of +the limbic system, which processes emotions, and an 8 percent loss of +tissue in the hippocampus, which is the gateway for memory. MRI scans +show that the damage in some ways is comparable to that found in +Alzheimer’s patients. But no matter how much meth destroys the brain, +addicts crave it because its high is up to twelve times the rush caused by +eating a delicious meal or even having sex. + +Basically, the “high” of drug addiction is due to the drug’s hijacking of +the brain’s own pleasure/reward system located in the limbic system." +"This pleasure/reward circuit is very primitive, dating back millions of +years in evolutionary history, but it is still extremely important for +human survival because it rewards beneficial behavior and punishes +harmful acts. Once this circuit is taken over by drugs, however, the +result can be widespread havoc. These drugs first penetrate the blood- +brain barrier and then cause the overproduction of neurotransmitters +like dopamine, which then floods the nucleus accumbens, a tiny pleasure +center located deep in the brain near the amygdala. The dopamine, in +turn, is produced by certain brain cells in the ventral tegmental area, +called VTA cells. + +All drugs basically work the same way: by crippling the VTA-nucleus +accumbens circuit, which controls the flow of dopamine and other +neurotransmitters to the pleasure center. Drugs differ only in the way in" +"which this process takes place. There are at least three main drugs that +stimulate the pleasure center of the brain: dopamine, serotonin, and +noradrenaline; all of them give feelings of pleasure, euphoria, and false +confidence, and also produce a burst of energy. + +Cocaine and other stimulants, for example, work in two ways. First, +they directly stimulate the VTA cells to produce more dopamine, hence +causing excess dopamine to flood into the nucleus accumbens. Second, +they prevent the VTA cells from going back to their “off” position, thus +keeping them continually producing dopamine. They also impede the +uptake of serotonin and noradrenaline. The simultaneous flooding of +neural circuits from all three of these neurotransmitters, then, creates +the tremendous high associated with cocaine. + +Heroin and other opiates, by contrast, work by neutralizing the cells in +the VTA that can reduce the production of dopamine, thus causing the +VTA to overproduce dopamine." +"Drugs like LSD operate by stimulating the production of serotonin, +inducing a feeling of well-being, purpose, and affection. But they also +activate areas of the temporal lobe involved in creating hallucinations. +(Only fifty micrograms of LSD can cause hallucinations. LSD binds so +tightly, in fact, that further increasing the dosage has no effect.) + +Over time, the CIA came to realize that mind-altering drugs were not +the magic bullet they were looking for. The hallucinations and +addictions that accompany these drugs made them too unstable and +unpredictable, and they could cause more trouble than they were worth + +in delicate political situations." +"(It should be pointed out that just in the last few years, MRI brain +scans of drug addicts have indicated a novel way to possibly cure or +treat some forms of addiction. By accident, it was noticed that stroke +victims who have damage to the insula [located deep in the brain, +between the prefrontal cortex and the temporal cortex] have a +significantly easier time quitting smoking than the average smoker. This +result has also been verified among drug abusers using cocaine, alcohol, +opiates, and nicotine. If this result holds up, it might mean that one may +be able to dampen the activity of the insula using electrodes or magnetic +stimulators and hence treat addiction. “This is the first time we’ve shown +anything like this, that damage to a specific brain area could remove the +problem of addiction entirely. It’s mind-boggling,” says Dr. Nora +Volkow, director of the National Institute on Drug Abuse. At present, no +one knows how this works, because the insula is involved in a" +"one knows how this works, because the insula is involved in a +bewildering variety of brain functions, including perception, motor +control, and self-awareness. But if this result bears out, it could change" +"the entire landscape of addiction studies.) + +PROBING THE BRAIN WITH OPTOGENETICS + +These mind-control experiments were done mainly in an era when the +brain was largely a mystery, with hit-or-miss methods that often failed. +However, because of the explosion in devices that can probe the brain, +new opportunities have arisen that will both help us understand the +brain as well as possibly teach us how to control it. + +Optogenetics, as we have seen, is one of the fastest-developing fields +in science today. The basic goal is to identify precisely which neural +pathway corresponds to which mode of behavior. Optogenetics starts +with a gene called opsin, which is quite unusual because it is sensitive to +light. (It is believed that the appearance of this gene hundreds of +millions of years ago was responsible for creating the first eye. In this +theory, a simple patch of skin sensitive to light due to opsin evolved into +the retina of the eye.)" +"When the opsin gene is inserted into a neuron and exposed to light, +the neuron will fire on command. By flipping a switch, one can instantly + +recognize the neural pathway for certain behaviors because the proteins +manufactured by opsin conduct electricity and will fire. + +The hard part, though, is to insert this gene into a single neuron. To +do this, one uses a technique borrowed from genetic engineering. The +opsin gene is inserted into a harmless virus (which has had its bad genes +removed), and, using precision tools, it is then possible to apply this +virus to a single neuron. The virus then infects the neuron by inserting +its genes into the genes of the neuron. Then, when a light beam is +flashed onto neural tissue, the neuron is turned on. In this way, one can +establish the precise pathway that certain messages take." +"Not only does optogenetics identify certain pathways by shining a +light beam on them, it also enables scientists to control behavior. +Already this method has been a proven success. It was long suspected +that a simple neural circuit must be responsible for fruit flies escaping +and flying away. Using this method, it was possible to finally identify the +precise pathway behind the quick getaway. By simply shining a beam +onto these fruit flies, they bolt on demand. + +Scientists are also now able to make worms stop wiggling by flashing +light, and in 2011 yet another breakthrough was made. Scientists at +Stanford were able to insert the opsin gene into a precise region of the + + amygdala of mice. These mice, which were specially bred to be timid, +cowered in their cage. But when a beam of light was flashed into their +brains, the mice suddenly lost their timidity and began to explore their +cage." +"The implications are enormous. While fruit flies may have simple +reflex mechanisms involving a handful of neurons, mice have complete +limbic systems with counterparts in the human brain. Although many +experiments that work with mice do not translate to human beings, this +still holds out the possibility that scientists may one day find the precise +neural pathways for certain mental illnesses, and then be able to treat +them without any side effects. As Dr. Edward Boyden of MIT says, “If +you want to turn off a brain circuit and the alternative is surgical +removal of a brain region, optical fiber implants might seem preferable.” + +One practical application is in treating Parkinson’s disease. As we have +seen, it can be treated by deep brain stimulation, but because the +positioning of electrodes in the brain lacks precision, there is always the +danger of strokes, bleeding, infections, etc. Deep brain stimulation can" +"also cause side effects such as dizziness and muscle contractions, because +the electrodes can accidentally stimulate the wrong neurons. +Optogenetics may improve deep brain stimulation by identifying the +precise neural pathways that are misfiring, at the level of individual +neurons. + +Victims of paralysis might also benefit from this new technology. As +we saw in Chapter 4, some paralyzed individuals have been hooked up +to a computer in order to control a mechanical arm, but because they +have no sense of touch, they often wind up dropping or crushing the +object they wish to grab. “By feeding information from sensors on the +prosthetic fingertips directly back to the brain using optogenetics, one +could in principle provide a high-fidelity sense of touch,” says Dr. +Krishna Shenoy of Stanford." +"Optogenetics will also help clarify which neural pathways are involved +with human behavior. In fact, plans have already been drawn up to +experiment with this technique on human brains, especially with regard +to mental illness. There will be hurdles, of course. First, the technique +requires opening up the skull, and if the neurons that one wishes to +study are located deep inside the brain, the procedure will be even more +invasive. Lastly, one has to insert tiny wires into the brain that can shine +a light on this modified neuron so that it triggers the desired behavior. + +Once these neural pathways have been deciphered, you can also +stimulate them, making animals perform strange behaviors (for example, +mice will run around in circles). Although scientists are just beginning to" +"trace the neural pathways governing simple animal behaviors, in the +future they should have an encyclopedia of such behaviors, including +those of humans. In the wrong hands, however, optogenetics could +potentially be used to control human behavior. + +In the main, the benefits of optogenetics greatly outweigh its +drawbacks. It can literally reveal the pathways of the brain in order to +treat mental illness and other diseases. This may then give scientists the +tools by which to repair the damage, perhaps curing diseases once +thought to be incurable. In the near future, then, the benefits are all +positive. But further in the future, once the pathways of human +behaviors are also understood, optogenetics could also be used to control +or at least modify human behavior as well. + +MIND CONTROL AND THE FUTURE" +"MIND CONTROL AND THE FUTURE + +In summary, the use of drugs and hypnotism by the CIA was a flop. +These techniques were too unstable and unpredictable to be of any use +to the military. They can be used to induce hallucinations and +dependency, but they have failed to cleanly erase memories, make +people more pliant, or force people to perform acts against their will. +Governments will keep trying, but the goal is elusive. So far, drugs are +simply too blunt an instrument to allow you to control someone’s +behavior. + +But this is also a cautionary tale. Carl Sagan mentions one nightmare +scenario that might actually work. He envisions a dictator taking +children and putting electrodes into their “pain” and “pleasure” centers. +These electrodes are then connected wirelessly to computers, so that the +dictator can control his subjects with the push of a button." +"Another nightmare might involve probes placed in the brain that +could override our wishes and seize control of our muscles, forcing us to +perform tasks we don’t want to do. The work of Dr. Delgado was crude, +but it showed that bursts of electricity applied to motor areas of the +brain can overrule our conscious thoughts, so that our muscles are no +longer under our control. He was able to identify only a few behaviors in +animals that could be controlled with electric probes. In the future, it +may be possible to find a wide variety of behaviors that can be +controlled electronically with a switch." +"If you are the person being controlled, it would be an unpleasant +experience. Although you may think you are master of your own body, +your muscles would actually fire without your permission, so you would +do things against your will. The electric impulse being fed into your +brain could be larger than the impulses you consciously send into your +muscles, so that it would appear as if someone had hijacked your body. + + Your own body would become a foreign object. + +In principle, some version of this nightmare might be possible in the +future. But there are several factors that may prevent this as well. First, +this is still an infant technology and it is not known how it will be +applied to human behavior, so there is still plenty of time to monitor its +development and perhaps create safeguards to see that it is not misused. +Second, a dictator might simply decide that propaganda and coercion," +"the usual methods of controlling a population, are cheaper and more +effective than putting electrodes into the brains of millions of children, +which would be costly and invasive. And third, in democratic societies, a +vigorous public debate would probably emerge concerning the promise +and limitations of this powerful technology. Laws would have to be +passed to prevent the abuse of these methods without impairing their +ability to reduce human suffering. Soon science will give us unparalleled +insight into the detailed neural pathways of the brain. A fine line has to +be drawn between technologies that can benefit society and technologies +that can control it. And the key to passing these laws is an educated, +informed public." +"But the real impact of this technology, I believe, will be to liberate the +mind, not enslave it. These technologies can give hope to those who are +trapped in mental illness. Although there is as yet no permanent cure for +mental illness, these new technologies have given us deep insight into +how such disorders form and how they progress. One day, through +genetics, drugs, and a combination of high-tech methods, we will find a +way to manage and eventually cure these ancient diseases. + +One of the recent attempts to exploit this new knowledge of the brain +is to understand historical personalities. Perhaps the insights from +modern science can help explain the mental states of those in the past. + +And one of the most mystifying figures being analyzed today is Joan +of Arc. + +Lovers and madmen have such seething brains.. +The lunatic, the lover, and the poet +Are of imagination all compact. + +-WILLIAM SHAKESPEARE, A MIDSUMMER NIGHT S DREAM + +9 ALTERED STATES OF CONSCIOUSNESS" +"-WILLIAM SHAKESPEARE, A MIDSUMMER NIGHT S DREAM + +9 ALTERED STATES OF CONSCIOUSNESS + + She was just an illiterate peasant girl who claimed to hear voices +directly from God. But Joan of Arc would rise from obscurity to lead a +demoralized army to victories that would change the course of nations, +making her one of the most fascinating, compelling, and tragic figures in +history." +"During the chaos of the Hundred Years’ War, when northern France +was decimated by English troops and the French monarchy was in +retreat, a young girl from Orleans claimed to have divine instructions to +lead the French army to victory. With nothing to lose, Charles VII +allowed her to command some of his troops. To everyone’s shock and +wonder, she scored a series of triumphs over the English. News rapidly +spread about this remarkable young girl. With each victory, her +reputation began to grow, until she became a folk heroine, rallying the +French around her. French troops, once on the verge of total collapse, +scored decisive victories that paved the way for the coronation of the +new king." +"However, she was betrayed and captured by the English. They realized +what a threat she posed to them, since she was a potent symbol for the +French and claimed guidance directly from God Himself, so they +subjected her to a show trial. After an elaborate interrogation, she was +found guilty of heresy and burned at the stake at the age of nineteen in +1431. + +In the centuries that followed, hundreds of attempts have been made +to understand this remarkable teenager. Was she a prophet, a saint, or a +madwoman? More recently, scientists have tried to use modern +psychiatry and neuroscience to explain the lives of historical figures such +as Joan of Arc. + +Few question her sincerity about claims of divine inspiration. But +many scientists have written that she might have suffered from +schizophrenia, since she heard voices. Others have disputed this fact," +"since the surviving records of her trial reveal a person of rational +thought and speech. The English laid several theological traps for her. +They asked, for example, if she was in God’s grace. If she answered yes, +then she would be a heretic, since no one can know for certain if they +are in God’s grace. If she said no, then she was confessing her guilt, and +that she was a fraud. Either way, she would lose. + +In a response that stunned the audience, she answered, “If I am not, +may God put me there; and if I am, may God so keep me.” The court +notary, in the records, wrote, “Those who were interrogating her were + + stupefied.” + +In fact, the transcripts of her interrogation are so remarkable that +George Bernard Shaw put literal translations of the court record in his +play Saint Joan." +"More recently, another theory has emerged about this exceptional +woman: perhaps she actually suffered from temporal lobe epilepsy. +People who have this condition sometimes experience seizures, but some +of them also experience a curious side effect that may shed some light on +the structure of human beliefs. These patients suffer from +“hyperreligiosity,” and can’t help thinking that there is a spirit or +presence behind everything. Random events are never random, but have +some deep religious significance. Some psychologists have speculated +that a number of history’s prophets suffered from these temporal lobe +epileptic lesions, since they were convinced they talked to God. The +neuroscientist Dr. David Eagleman says, “Some fraction of history’s +prophets, martyrs, and leaders appear to have had temporal lobe +epilepsy. Consider Joan of Arc, the sixteen-year-old girl who managed to +turn the tide of the Hundred Years’ War because she believed (and" +"turn the tide of the Hundred Years’ War because she believed (and +convinced the French soldiers) that she was hearing voices from Saint +Michael the archangel, Saint Catherine of Alexandria, Saint Margaret, +and Saint Gabriel.”" +"This curious effect was noticed as far back as 1892, when textbooks on +mental illness noted a link between “religious emotionalism” and +epilepsy. It was first clinically described in 1975 by neurologist Norman +Geschwind of Boston Veterans Administration Hospital. He noticed that +epileptics who had electrical misfirings in their left temporal lobes often +had religious experiences, and he speculated that the electrical storm in +the brain somehow was the cause of these religious obsessions. + +Dr. V. S. Ramachandran estimates that 30 to 40 percent of all the +temporal lobe epileptics whom he has seen suffer from hyperreligiosity. +He notes, “Sometimes it’s a personal God, sometimes it’s a more diffuse +feeling of being one with the cosmos. Everything seems suffused with +meaning. The patient will say, ‘Finally, I see what it is all really about, +Doctor. I really understand God. I understand my place in the universe— +the cosmic scheme.’ ”" +"He also notes that many of these individuals are extremely adamant +and convincing in their beliefs. He says, “I sometimes wonder whether +such patients who have temporal lobe epilepsy have access to another +dimension of reality, a wormhole of sorts into a parallel universe. But I +usually don’t say this to my colleagues, lest they doubt my sanity.” He +has experimented on patients with temporal lobe epilepsy, and +confirmed that these individuals had a strong emotional reaction to the + + word “God” but not to neutral words. This means that the link between +hyperreligiosity and temporal lobe epilepsy is real, not just anecdotal. + +Psychologist Michael Persinger asserts that a certain type of +transcranial electrical stimulation (called transcranial magnetic +simulation, or TMS) can deliberately induce the effect of these epileptic +lesions. If this is so, is it possible that magnetic fields can be used to alter +one’s religious beliefs?" +"In Dr. Persinger’s studies, the subject places a helmet on his head +(dubbed the “God helmet”), which contains a device that can send +magnetism into particular parts of the brain. Afterward, when the +subject is interviewed, he will often claim that he was in the presence of +some great spirit. David Biello, writing in Scientific American, says, +“During the three-minute bursts of stimulation, the affected subjects +translated this perception of the divine into their own cultural and +religious language—terming it God, Buddha, a benevolent presence, or +the wonder of the universe.” Since this effect is reproducible on demand, +it indicates that perhaps the brain is hardwired in some way to respond +to religious feelings." +"Some scientists have gone further and have speculated that there is a +“God gene” that predisposes the brain to be religious. Since most +societies have created a religion of some sort, it seems plausible that our +ability to respond to religious feelings might be genetically programmed +into our genome. (Meanwhile, some evolutionary theorists have tried to + +explain these facts by claiming that religion served to increase the +chances of survival for early humans. Religion helped bond bickering +individuals into a cohesive tribe with a common mythology, which +increased the chances that the tribe would stick together and survive.) + +Would an experiment like the one using the “God helmet” shake a +person’s religious beliefs? And can an MRI machine record the brain +activity of someone who experiences a religious awakening?" +"To test these ideas, Dr. Mario Beauregard of the University of +Montreal recruited a group of fifteen Carmelite nuns who agreed to put +their heads into an MRI machine. To qualify for the experiment, all of +them must “have had an experience of intense union with God.” + +Originally, Dr. Beauregard had hoped that the nuns would have a +mystical communion with God, which could then be recorded by an MRI +scan. However, being shoved into an MRI machine, where you are +surrounded by tons of magnetic coils of wire and high-tech equipment, is +not an ideal setting for a religious epiphany. The best they could do was +to evoke memories of previous religious experiences. “God cannot be + + summoned at will,” explained one of the nuns. + +The final result was mixed and inconclusive, but several regions of the +brain clearly lit up during this experiment: + +• The caudate nucleus, which is involved with learning and possibly +falling in love. (Perhaps the nuns were feeling the unconditional +love of God?)" +"• The insula, which monitors body sensations and social emotions. +(Perhaps the nuns were feeling close to the other nuns as they were +reaching out to God?) + +• The parietal lobe, which helps process spatial awareness. (Perhaps +the nuns felt they were in the physical presence of God?) + +Dr. Beauregard had to admit that so many areas of the brain were +activated, with so many different possible interpretations, that he could +not say for sure whether hyperreligiosity could be induced. However, it +was clear to him that the nuns’ religious feelings were reflected in their +brain scans. + +But did this experiment shake the nuns’ belief in God? No. In fact, the + +nuns concluded that God placed this “radio” in the brain so that we +could communicate with Him." +"nuns concluded that God placed this “radio” in the brain so that we +could communicate with Him. + +Their conclusion was that God created humans to have this ability, so +the brain has a divine antenna given to us by God so that we can feel His +presence. David Biello concludes, “Although atheists might argue that +finding spirituality in the brain implies that religion is nothing more +than divine delusion, the nuns were thrilled by their brain scans for +precisely the opposite reason: they seemed to provide confirmation of +God’s interactions with them.” Dr. Beauregard concluded, “If you are an +atheist and you live a certain kind of experience, you will relate it to the +magnificence of the universe. If you are a Christian, you will associate it +with God. Who knows. Perhaps they are the same thing.” + +Similarly, Dr. Richard Dawkins, a biologist at Oxford University and +an outspoken atheist, was once placed in the God helmet to see if his +religious beliefs would change. + +They did not." +"They did not. + +So in conclusion, although hyperreligiosity may be induced via +temporal lobe epilepsy and even magnetic fields, there is no convincing +evidence that magnetic fields can alter one’s religious views. + + MENTAL ILLNESS + +But there is another altered state of consciousness that brings great +suffering, both to the person experiencing it and to his or her family, and +this is mental illness. Can brain scans and high technology reveal the +origin of this affliction and perhaps lead to a cure? If so, one of the +largest sources of human suffering could be eliminated." +"For example, throughout history, the treatment of schizophrenia was +brutal and crude. People who suffer from this debilitating mental +disorder, which afflicts about 1 percent of the population, typically hear +imaginary voices and suffer from paranoid delusions and disorganized +thinking. Throughout history, they were considered to be “possessed” by +the devil and were banished, killed, or locked up. Gothic novels +sometimes refer to the strange, demented relative who lives in the +darkness of a hidden room or basement. The Bible even mentions an +incident when Jesus encountered two demoniacs. The demons begged + +Jesus to drive them into a herd of swine. He said, “Go then.” When the +demons entered the swine, the whole herd rushed down the bank and +drowned in the sea." +"Even today, you still see people with classic symptoms of +schizophrenia walking around having arguments with themselves. The +first indicators usually surface in the late teens (for men) or early +twenties (for women). Some schizophrenics have led normal lives and +even performed remarkable feats before the voices finally took over. The +most famous case is that of the 1994 Nobel Prize winner in economics, +John Nash, who was played by Russell Crowe in the movie A Beautiful +Mind. In his twenties, Nash did pioneering work in economics, game +theory, and pure mathematics at Princeton University. One of his +advisers wrote him a letter of recommendation with just one line: “This +man is a genius.” Remarkably, he was able to perform at such a high +intellectual level even while being hounded by delusions. He was finally +hospitalized when he had a breakdown at age thirty-one, and spent +many years in institutions or wandering around the world, fearing that +communist agents would kill him." +"At present, there is no precise, universally accepted way to diagnose +mental illness. There is hope, however, that one day scientists will use +brain scans and other high-tech devices to create accurate diagnostic +tools. Progress in treating mental illness, therefore, has been painfully +slow. After centuries of suffering, victims of schizophrenia had their first +sign of relief when antipsychotic drugs like thorazine were found + + accidentally in the 1950s that could miraculously control or even at +times eliminate the voices that haunted the mentally ill." +"It is believed that these drugs work by regulating the level of certain +neurotransmitters, such as dopamine. Specifically, the theory is that +these drugs block the functioning of D2 receptors of certain nerve cells, +thereby reducing the level of dopamine. (This theory, that hallucinations +were in part caused by excess dopamine levels in the limbic system and +prefrontal cortex, also explained why people taking amphetamines +experienced similar hallucinations.) + +Dopamine, because it is so essential for the synapses of the brain, has +been implicated in other disorders as well. One theory holds that +Parkinson’s disease is aggravated by a lack of dopamine in the synapses, +while Tourette’s syndrome can be triggered by an overabundance of it. + +(People with Tourette’s syndrome have tics and unusual facial +movements. A small minority of them uncontrollably speak obscene +words and make profane, derogatory remarks.)" +"More recently, scientists have zeroed in on another possible culprit: +abnormal glutamate levels in the brain. One reason for believing these +levels are involved is that PCP (angel dust) is known to create +hallucinations similar to those of schizophrenics by blocking a glutamate +receptor called NMDA. Clozapine, a relatively new drug for +schizophrenia that stimulates the production of glutamate, shows great +promise. + +However, these antipsychotic drugs are not a cure-all. In about 20 +percent of cases, such drugs stop all symptoms. About two-thirds find +some relief from their symptoms, but the rest are totally unaffected. +(According to one theory, antipsychotic drugs mimic a natural chemical +that is missing in schizophrenics’ brains, but it is not an exact copy. +Hence a patient has to try a variety of these antipsychotic drugs, almost +by trial and error. Moreover, they can have unpleasant side effects, so +schizophrenics often stop taking them and suffer a relapse.)" +"Recently, brain scans of schizophrenics taken while they were having +auditory hallucinations have helped explain this ancient disorder. For +example, when we silently talk to ourselves, certain parts of the brain +light up on an MRI scan, especially in the temporal lobe (such as in +Wernicke’s area). When a schizophrenic hears voices, the very same +areas of the brain light up. The brain works hard to construct a +consistent narrative, so schizophrenics try to make sense of these +unauthorized voices, believing they originate from strange sources, such +as Martians secretly beaming thoughts into their brains. Dr. Michael +Sweeney of Ohio State writes, “Neurons wired for the sensation of sound + + fire on their own, like gas-soaked rags igniting spontaneously in a hot, +dark garage. In the absence of sights and sounds in the surrounding +environment, the schizophrenic’s brain creates a powerful illusion of +reality.”" +"Notably, these voices seem to be coming from a third party, who often +gives the subject commands, which are mostly mundane but sometimes +violent. Meanwhile, the simulation centers in the prefrontal cortex seem +to be on automatic pilot, so in a way it’s as though the consciousness of +a schizophrenic is running the same sort of simulations we all do, except + +they’re done without his permission. The person is literally talking to +himself without his knowledge. + +HALLUCINATIONS + +The mind constantly generates hallucinations of its own, but for the +most part they are easily controlled. We see images that don’t exist or +hear spurious sounds, for example, so the anterior cingulate cortex is +vital to distinguish the real from the manufactured. This part of the +brain helps us distinguish between stimuli that are external and those +that are internally generated by the mind itself." +"However, in schizophrenics, it is believed that this system is damaged, +so that the person cannot distinguish real from imaginary voices. (The +anterior cingulate cortex is vital because it lies in a strategic place, +between the prefrontal cortex and the limbic system. The link between +these two areas is one of the most important in the brain, since one area +governs rational thinking, and the other emotions.) + +Hallucinations, to some extent, can be created on demand. +Hallucinations occur naturally if you place someone in a pitch-black +room, an isolation chamber, or a creepy environment with strange +noises. These are examples of “our eyes playing tricks on us.” Actually, +the brain is tricking itself, internally creating false images, trying to +make sense of the world and identify threats. This effect is called +“pareidolia.” Every time we look at clouds in the sky, we see images of +animals, people, or our favorite cartoon characters. We have no choice. +It is hardwired into our brains." +"In a sense, all images we see, both real and virtual, are hallucinations, +because the brain is constantly creating false images to “fill in the gaps.” +As we’ve seen, even real images are partly manufactured. But in the +mentally ill, regions of the brain such as the anterior cingulate cortex are +perhaps damaged, so the brain confuses reality and fantasy. + + THE OBSESSIVE MIND + +Another disorder in which drugs may be used to heal the mind is OCD +(obsessive-compulsive disorder). As we saw earlier, human + +consciousness involves mediating between a number of feedback +mechanisms. Sometimes, however, the feedback mechanisms are stuck in +the “on” position." +"One in forty Americans suffers from OCD. Cases can be mild, so that, +for example, people have to constantly go home to check that they +locked the door. The detective Adrian Monk on the TV show Monk has a +mild case of OCD. But OCD can also be so severe that people +compulsively scratch or wash their skin until it is left bleeding and raw. +Some people with OCD have been known to repeat obsessive behaviors +for hours, making it difficult to keep a job or have a family. + +Normally these types of compulsive behaviors, in moderation, are +actually good for us, since they help us keep clean, healthy, and safe. +That is why we evolved these behaviors in the first place. But someone +with OCD cannot stop this behavior, and it spirals out of control." +"Brain scans are now revealing how this takes place. They show that at +least three areas of the brain that normally help us keep ourselves +healthy get stuck in a feedback loop. First, there is the orbitofrontal +cortex, which we saw in Chapter 1 can act as a fact-checker, making sure +that we have properly locked the doors and washed our hands. It tells +us, “Hmm, something is wrong.” Second, the caudate nucleus, located in +the basal ganglia, governs learned activities that are automatic. It tells +the body to “do something.” And finally, we have the cingulate cortex, +which registers conscious emotions, including discomfort. It says, “I still +feel awful.”" +"Psychiatry professor Jeffrey Schwartz of UCLA has tried to put this all +together to explain how OCD gets out of hand. Imagine you have the +urge to wash your hands. The orbitofrontal cortex recognizes that +something is wrong, that your hands are dirty. The caudate nucleus kicks +in and causes you to automatically wash your hands. Then the cingulate +cortex registers satisfaction that your hands are clean. + +But in someone with OCD, this loop is altered. Even after he notices +that his hands are dirty and he washes them, he still has the +discomforting feeling that something is wrong, that they are still dirty. +So he is stuck in a feedback loop that won’t stop. + + In the 1960s, the drug clomipramine hydrochloride began to give OCD +patients some relief. This and other drugs developed since then raise +levels of the neurotransmitter serotonin in the body. They can reduce" +"symptoms of OCD by as much as 60 percent in clinical trials. Dr. +Schwartz says, “The brain’s gonna do what the brain’s gonna do, but you +don’t have to let it push you around.” These drugs are certainly not a +cure, but they have brought some relief to the sufferers of OCD. + +BIPOLAR DISORDER + +Another common form of mental illness is bipolar disorder, in which a +person suffers from extreme bouts of wild, delusional optimism, followed +by a crash and then periods of deep depression. Bipolar disorder also +seems to run in families and, curiously, strikes frequently in artists; +perhaps their great works of art were created during bursts of creativity +and optimism. A list of creative people who were afflicted by bipolar +disorder reads like a Who’s Who of Hollywood celebrities, musicians, +artists, and writers. Although the drug lithium seems to control many of +the symptoms of bipolar disorder, the causes are not entirely clear." +"One theory states that bipolar disorder may be caused by an +imbalance between the left and right hemispheres. Dr. Michael Sweeney +notes, “Brain scans have led researchers to generally assign negative +emotions such as sadness to the right hemisphere and positive emotions +such as joy to the left hemisphere. For at least a century, neuroscientists +have noticed a link between damage to the brain’s left hemisphere and +negative moods, including depression and uncontrollable crying. +Damage to the right, however, has been associated with a broad array of +positive emotions.”" +"So the left hemisphere, which is analytical and controls language, +tends to become manic if left to itself. The right hemisphere, on the +contrary, is holistic and tends to check this mania. Dr. V. S. +Ramachandran writes, “If left unchecked, the left hemisphere would +likely render a person delusional or manic.... So it seems reasonable to +postulate a ‘devil’s advocate’ in the right hemisphere that allows ‘you’ to +adopt a detached, objective (allocentric) view of yourself.” + +If human consciousness involves simulating the future, it has to +compute the outcomes of future events with certain probabilities. It +needs, therefore, a delicate balance between optimism and pessimism to +estimate the chances of success or failures for certain courses of action." +"But in some sense, depression is the price we pay for being able to +simulate the future. Our consciousness has the ability to conjure up all +sorts of horrific outcomes for the future, and is therefore aware of all the +bad things that could happen, even if they are not realistic." +"It is hard to verify many of these theories, since brain scans of people +who are clinically depressed indicate that many brain areas are affected. +It is difficult to pinpoint the source of the problem, but among the +clinically depressed, activity in the parietal and temporal lobes seems to +be suppressed, perhaps indicating that the person is withdrawn from the +outside world and living in their own internal world. In particular, the +ventromedial cortex seems to play an important role. This area +apparently creates the feeling that there is a sense of meaning and +wholeness to the world, so that everything seems to have a purpose. +Overactivity in this area can cause mania, in which people think they are +omnipotent. Underactivity in this area is associated with depression and +the feeling that life is pointless. So it is possible that a defect in this area +may be responsible for some mood swings. + +A THEORY OF CONSCIOUSNESS AND MENTAL ILLNESS" +"A THEORY OF CONSCIOUSNESS AND MENTAL ILLNESS + +So how does the space-time theory of consciousness apply to mental +illness? Can it give us a deeper insight into this disorder? As we +mentioned before, we define human consciousness as the process of +creating a model of our world in space and time (especially the future) +by evaluating many feedback loops in various parameters in order to +achieve a goal." +"We have proposed that the key function of human consciousness is to +simulate the future, but this is not a trivial task. The brain accomplishes +it by having these feedback loops check and balance one another. For +example, a skillful CEO at a board meeting tries to draw out the +disagreement among staff members and to sharpen competing points of +view in order to sift through the various arguments and then make a +final decision. In the same way, various regions of the brain make +diverging assessments of the future, which are given to the dorsolateral +prefrontal cortex, the CEO of the brain. These competing assessments are +then evaluated and weighed until a balanced final decision is made. + +We can now apply the space-time theory of consciousness to give us a +definition of most forms of mental illness: + +Mental illness is largely caused by the disruption of the +delicate checks and balances between competing feedback" +"loops that simulate the future (usually because one region of +the brain is overactive or underactive). + +Because the CEO of the mind (the dorsolateral prefrontal cortex) no +longer has a balanced assessment of the facts, due to this disruption in +feedback loops, it begins to make strange conclusions and act in bizarre +ways. The advantage of this theory is that it is testable. One has to +perform MRI scans of the brain of someone who is mentally ill as it +exhibits dysfunctional behavior, evaluating how its feedback loops are +performing, and compare it to the MRI scans of normal people. If this +theory is correct, the dysfunctional behavior (for example, hearing +voices or becoming obsessed) can be traced back to a malfunctioning of +the checks and balances between feedback loops. The theory can be +disproven if this dysfunctional behavior is totally independent of the +interplay between these regions of the brain." +"Given this new theory of mental illness, we can now apply it to +various forms of mental disorders, summarizing the previous discussion +in this new light. + +We saw earlier that the obsessive behavior of people suffering from +OCD might arise when the checks and balances between several +feedback loops are thrown out of balance: one registering something as +amiss, another carrying out corrective action, and another one signaling +that the matter has been taken care of. The failure of the checks and +balances within this loop can cause the brain to be locked into a vicious +cycle, so the mind never believes that the problem has been resolved." +"The voices heard by schizophrenics might arise when several feedback +loops are no longer balancing one another. One feedback loop generates +spurious voices in the temporal cortex (i.e., the brain is talking to itself). +Auditory and visual hallucinations are often checked by the anterior +cingulate cortex, so a normal person can differentiate between real and +fictitious voices. But if this region of the brain is not working properly, +the brain is flooded with disembodied voices that it believes are real. + +This can cause schizophrenic behavior. + +Similarly, the manic-depressive swings of someone with bipolar +disorder might be traced to an imbalance between the left and right +hemispheres. The necessary interplay between optimistic and pessimistic +assessments is thrown off balance, and the person oscillates wildly +between these two diverging moods." +"Paranoia may also be viewed in this light. It results from an imbalance +between the amygdala (which registers fear and exaggerates threats) and +the prefrontal cortex, which evaluates these threats and puts them into + + perspective. + +We should also stress that evolution has given us these feedback loops +for a reason: to protect us. They keep us clean, healthy, and socially +connected. The problem occurs when the dynamic between opposing +feedback loops is disrupted. + +This theory can be roughly summarized as follows: + +MENTAL ILLNESS + +Paranoia + +FEEDBACK LOOP #1 + +Perceiving a threat + +FEEDBACK LOOP #2 + +Discounting threats + +BRAIN REGION AFFECTED + +Amygdala/prefrontal lobe + +MENTAL ILLNESS + +Schizophrenia + +FEEDBACK LOOP #1 + +Creating voices + +FEEDBACK LOOP #2 + +Discounting voices + +BRAIN REGION AFFECTED + +Left temporal lobe/anterior cingulate cortex + +MENTAL ILLNESS + +Bipolar disorder + + FEEDBACK LOOP #1 + +Optimism + +FEEDBACK LOOP #2 + +Pessimism + +BRAIN REGION AFFECTED + +Left/right hemisphere" +"Optimism + +FEEDBACK LOOP #2 + +Pessimism + +BRAIN REGION AFFECTED + +Left/right hemisphere + +MENTAL ILLNESS + +OCD + +FEEDBACK LOOP #1 + +Anxiety + +FEEDBACK LOOP #2 + +Satisfaction + +BRAIN REGION AFFECTED + +Orbitofrontal cortex/caudate nucleus/cingulate cortex + +According to the space-time theory of consciousness, many forms of mental illness are typified by the +disruption of the +checks and balances of opposing feedback loops in the brain that simulate the future. Brain scans are +gradually +identifying which regions these are. A more complete understanding of mental illness will undoubtedly +reveal the +involvement of many more regions of the brain. This is only a preliminary sketch. + +DEEP BRAIN STIMULATION + +Although the space-time theory of consciousness may give us insight into +the origin of mental illness, it doesn’t tell us how to create new therapies +and remedies." +"How will science deal with mental illness in the future? This is hard to +predict, since we now realize that mental illness is not just one category, +but an entire range of illnesses that can afflict the mind in a bewildering +number of ways. Furthermore, the science behind mental illness is still in + + its infancy, with huge areas totally unexplored and unexplained. + +But a new method is being tried today to treat the unending agony of +people suffering from one of the most common yet stubbornly persistent +forms of mental disorder, depression, which afflicts twenty million +people in the United States. Ten percent of them, in turn, suffer from an +incurable form of depression that has resisted all medical advances. One +direct way of treating them, which holds much promise, is to place +probes deep inside certain regions of the brain." +"An important clue to this disorder was discovered by Dr. Helen +Mayberg and colleagues, then doing research at Washington University +Medical School. Using brain scans, they identified an area of the brain, +called Brodmann area 25 (also called the subcallosal cingulate region), +in the cerebral cortex that is consistently hyperactive in depressed +individuals for whom all other forms of treatment have been +unsuccessful." +"These scientists used deep brain stimulation (DBS) in this area, +inserting a small probe into the brain and applying an electrical shock, +much like a pacemaker. The success of DBS has been astonishing in the +treatment of various disorders. In the past decade, DBS has been used on +forty thousand patients for motor-related diseases, such as Parkinson’s +and epilepsy, which cause uncontrolled movements of the body. +Between 60 and 100 percent of patients report significant improvement +in controlling their shaking hands. More than 250 hospitals in the United +States alone now perform DBS treatments. + +But then Dr. Mayberg had the idea of applying DBS directly to +Brodmann area 25 to treat depression as well. Her team took twelve +patients who were clinically depressed and had shown no improvement +after exhaustive use of drugs, psychotherapy, and electroshock therapy." +"They found that eight of these chronically depressed individuals +immediately showed progress. Their success was so astonishing, in fact, +that other groups raced to duplicate these results and apply DBS to other +mental disorders. At present, DBS is being applied to thirty-five patients +at Emory University, and thirty at other institutions. + +Dr. Mayberg says, “Depression 1.0 was psychotherapy—people +arguing about whose fault it was. Depression 2.0 was the idea that it’s a +chemical imbalance. This is Depression 3.0. What has captured +everyone’s imagination is that, by dissecting a complex behavior + +disorder into its component systems, you have a new way of thinking +about it.”" +"disorder into its component systems, you have a new way of thinking +about it.” + + Although the success of DBS in treating depressed individuals is +remarkable, much more research needs to be done. First, it is not clear +why DBS works. It is thought that DBS destroys or impairs overactive +areas of the brain (as in Parkinson’s and Brodmann area 25) and is hence +effective only against ailments caused by such overactivity. Second, the +precision of this tool needs to be improved. Although this treatment has +been used to treat a variety of brain diseases, such as phantom limb pain +(when a person feels pain from a limb that has been amputated), +Tourette’s syndrome, and obsessive-compulsive disorder, the electrode +inserted into the brain is not precise, thus affecting perhaps several +million neurons rather than just the handful that are the source of +distress." +"Time will only improve the effectiveness of this therapy. Using MEM +technology, one can create microscopic electrodes able to stimulate only +a few neurons at a time. Nanotechnology may also make possible neural +nanoprobes that are one molecule thick, as in carbon nanotubes. And as +MRI sensitivity increases, our capability to guide these electrodes to +more specific areas of the brain should grow more precise. + +WAKING UP FROM A COMA + +Deep brain stimulation has branched into several different avenues of +research, including a beneficial side effect: increasing the number of +memory cells within the hippocampus. Yet another application is to +revive some individuals in a coma." +"Comas represent perhaps one of the most controversial forms of +consciousness, and often results in national headlines. The case of Terri +Schiavo, for example, riveted the public. Due to a heart attack, she +suffered a lack of oxygen, which caused massive brain injury. As a result, +Schiavo went into a coma in 1990. Her husband, with the approval of +doctors, wanted to allow her the dignity of dying peacefully. But her +family said this was cruelly pulling the plug on someone who still had +some responses to stimuli and might one day be miraculously revived. +They pointed out that there had been sensational cases in the past when + +coma patients suddenly regained consciousness after many years in a +vegetative state. + +Brain scans were used to settle the question. In 2003, most +neurologists, examining the CAT scans, concluded that the damage to +Schiavo’s brain was so extensive that she could never be revived, and +that she was in a permanent vegetative state (PVS). After she died in" +"2005, an autopsy confirmed these results—there was no chance of +revival. + +In some other cases involving coma patients, however, brain scans +show that the damage is not so severe, so there is a slim chance of +recovery. In the summer of 2007, a man in Cleveland woke up and +greeted his mother after undergoing deep brain stimulation. The man +had suffered extensive brain damage eight years earlier and fell into a +deep coma known as a minimally conscious state." +"Dr. Ali Rezai led the team of surgeons who performed the operation. +They inserted a pair of wires into the patient’s brain until they reached +the thalamus, which, as we have seen, is the gateway where sensory +information is first processed. By sending a low-voltage current through +these wires, the doctors were able to stimulate the thalamus, which in +turn woke the man up from his deep coma. (Usually, sending electricity +into the brain causes that part of the brain to shut down, but under +certain circumstances it can act to jolt neurons into action.)" +"Improvements in DBS technology should increase the number of +success stories in different fields. Today a DBS electrode is about 1.5 +millimeters in diameter, but it touches up to a million neurons when +inserted into the brain, which can cause bleeding and damage to blood +vessels. One to three percent of DBS patients in fact have bleeding that +can progress to a stroke. The electric charge carried by DBS probes is +also still very crude, pulsing at a constant rate. Eventually, surgeons will +be able to adjust the electrical charge carried by the electrodes so that +each probe is made for a specific person and a specific ailment. The next +generation of DBS probes is bound to be safer and more precise. + +THE GENETICS OF MENTAL ILLNESS + +Another attempt to understand and eventually treat mental illness" +"Another attempt to understand and eventually treat mental illness + +involves tracing its genetic roots. Many attempts have been made in this +area, with disappointing, mixed results. There is considerable evidence +that schizophrenia and bipolar disorder run in families, but attempts to +find the genes common to all these individuals have not been conclusive. +Occasionally scientists have followed the family trees of certain +individuals afflicted by mental illness and found a gene that is prevalent. +But attempts to generalize this result to other families have often failed. +At best, scientists have concluded that environmental factors as well as a +combination of several genes are necessary to trigger mental illness. +However, it has generally been accepted that each disorder has its own +genetic basis." +"In 2012, however, one of the most comprehensive studies ever done +showed that there could in fact be a common genetic factor to mental +illness after all. Scientists from the Harvard Medical School and +Massachusetts General Hospital analyzed sixty thousand people +worldwide and found that there was a genetic link between five major +mental illnesses: schizophrenia, bipolar disorder, autism, major +depression, and attention deficit hyperactivity disorder (ADHD). +Together they represent a significant fraction of all mentally ill patients." +"After an exhaustive analysis of the subjects’ DNA, scientists found that +four genes increased the risk of mental illness. Two of them involved the +regulation of calcium channels in neurons. (Calcium is an essential +chemical involved in the processing of neural signals.) Dr. Jordan +Smoller of the Harvard Medical School says, “The calcium channels +findings suggest that perhaps—and that is a big if—treatments to affect +calcium channeling functioning might have effects across a range of +disorders.” Already, calcium channel blockers are being used to treat +people with bipolar disorder. In the future, these blockers may be used +to treat other mental illnesses as well. + +This new result could help explain the curious fact that when mental +illness runs in a family, members may manifest different forms of +disorders. For example, if one twin has schizophrenia, then the other +twin might have a totally different disorder, such as bipolar disorder." +"The point here is that although each mental illness has its own triggers +and genes, there could be a common thread running through them as +well. Isolating the common factors among these diseases could give us a +clue to which drugs might be most effective against them. + +“What we have identified here is probably just the tip of the iceberg,” +says Dr. Smoller. “As these studies grow, we expect to find additional +genes that might overlap.” If more genes are found among these five +disorders, it could open up an entirely new approach to mental illness. + +If more common genes are found, it could mean that gene therapy +might be able to repair the damage caused by defective genes. Or it +might give rise to new drugs that could treat the illness at the neural +level. + +FUTURE AVENUES + +So at present, there is no cure for patients with mental illness. +Historically, doctors were helpless in treating them. But modern" +"medicine has given us a variety of new possibilities and therapies to +tackle this ancient problem. Just a few of them include: + +1. Finding new neurotransmitters and new drugs that regulate the +signaling of neurons. + +2. Locating the genes linked to various mental illnesses, and perhaps +using gene therapy. + +3. Using deep brain stimulation to dampen or increase neural activity +in certain areas. + +4. Using EEG, MRI, MEG, and TES to understand precisely how the +brain malfunctions. + +5. And in the chapter on reverse engineering the brain, we will +explore yet another promising avenue, imaging the entire brain and +all its neural pathways. This may finally unravel the mystery of +mental illnesses. + +But to make sense of the wide variety of mental illnesses, some +scientists believe that mental illnesses can be grouped into at least two +major groups, each one requiring a different approach: + +1. Mental disorders involving injury to the brain" +"1. Mental disorders involving injury to the brain + +2. Mental disorders triggered by incorrect wiring within the brain + +The first type includes Parkinson’s, epilepsy, Alzheimer’s, and a wide +variety of disorders caused by strokes and tumors, in which brain tissue +is actually injured or malfunctioning. In the case of Parkinson’s and +epilepsy, there are neurons in a precise area of the brain that are +overactive. In Alzheimer’s, a buildup of amyloid plaque destroys brain +tissue, including the hippocampus. In strokes and tumors, certain parts +of the brain are silenced, causing numerous behavioral problems. Each +of these disorders has to be treated differently, since each injury is +different. Parkinson’s and epilepsy may require probes to silence the +overactive areas, while damage from Alzheimer’s, strokes, and tumors is +often incurable." +"In the future, there will be advances in methods to deal with these +injured parts of the brain besides deep brain stimulation and magnetic +fields. One day stem cells may replace brain tissue that has been +damaged. Or perhaps artificial replacements can be found to compensate +for these injured areas using computers. In this case, the injured tissue is +removed or replaced, either organically or electronically. + + The second category involves disorders caused by a miswiring of the +brain. Disorders like schizophrenia, OCD, depression, and bipolar +disorder might fall into this category. Each region of the brain may be +relatively healthy and intact, but one or more of them may be miswired, +causing messages to be processed incorrectly. This category is difficult to +treat, since the wiring of the brain is not well understood. So far, the +main way to deal with these disorders is through drugs that influence +neurotransmitters, but there is still a lot of hit or miss involved here." +"But there is another altered state of consciousness that has given us +new insights into the working mind. It has also provided new +perspectives on how the brain works and what might happen if there is a +disorder. This is the field of AI, artificial intelligence. Although it is still +in its infancy, it has opened profound insights into the thinking process +and has even deepened our understanding of human consciousness. So +the questions are: Can silicon consciousness be achieved? If so, how +might it differ from human consciousness? And will it try one day to +control us? + +No, I’m not interested in developing a powerful brain. All I’m +after is just a mediocre brain, something like the President of +the American Telephone and Telegraph Company. + +—ALAN TURING + +10 THE ARTIFICIAL MIND AND SILICON +CONSCIOUSNESS + +In February 2011, history was made." +"10 THE ARTIFICIAL MIND AND SILICON +CONSCIOUSNESS + +In February 2011, history was made. + +An IBM computer called Watson did what many critics thought was +impossible: it beat two contestants on a TV game show called Jeopardy! +Millions of viewers were glued to the screen as Watson methodically +annihilated its opponents on national TV, answering questions that +stumped the rival contestants, and thereby claiming the $1 million prize +money. + +IBM pulled out all the stops in assembling a machine with a truly +monumental amount of computational firepower. Watson can process +data at the astonishing rate of five hundred gigabytes per second (or the +equivalent of a million books per second) with sixteen trillion bytes of +RAM memory. It also had access to two hundred million pages of +material in its memory, including the entire storehouse of knowledge + + within Wikipedia. Watson could then analyze this mountain of +information on live TV." +"within Wikipedia. Watson could then analyze this mountain of +information on live TV. + +Watson is just the latest generation of “expert systems,” software +programs that use formal logic to access vast amounts of specialized +information. (When you talk on the phone to a machine that gives you a +menu of choices, this is a primitive expert system.) Expert systems will +continue to evolve, making our lives more convenient and efficient. + +For example, engineers are currently working to create a “robo-doc,” +which will appear on your wristwatch or wall screen and give you basic +medical advice with 99 percent accuracy almost for free. You’d talk to it +about your symptoms, and it would access the databanks of the world’s +leading medical centers for the latest scientific information. This will +reduce unnecessary visits to the doctor, eliminate costly false alarms, +and make it effortless to have regular conversations with a doctor." +"Eventually we might have robot lawyers that can answer all common +legal questions, or a robo-secretary that can plan vacations, trips, and + +dinners. (Of course, for specialized services requiring professional +advice, you would still need to see a real doctor, lawyer, etc., but for +common, everyday advice, these programs would suffice.) + +In addition, scientists have created “chat-bots” that can mimic +ordinary conversations. The average person may know tens of thousands +of words. Reading the newspaper may require about two thousand words +or more, but a casual conversation usually involves only a few hundred. +Robots can be programmed to converse with this limited vocabulary (as +long as the conversation is limited to certain well-defined subjects). + +MEDIA HYPE—THE ROBOTS ARE COMING" +"MEDIA HYPE—THE ROBOTS ARE COMING + +Soon after Watson won that contest, some pundits were wringing their +hands, mourning the day when the machines will take over. Ken +Jennings, one of the contestants defeated by Watson, remarked to the +press, “I for one welcome our new computer overlords.” The pundits +asked, If Watson could defeat seasoned game show contestants in a +head-to-machine contest, then what chance do the rest of us mortals +have to stand up to the machines? Half jokingly, Jennings said, “Brad +[the other contestant] and I were the first knowledge-industry workers +put out of work by the new generation of ‘thinking’ machines.” + +The commentators, however, forgot to mention that you could not go +up to Watson and congratulate it for winning. You could not slap it on" +"its back, or share a champagne toast with it. It wouldn’t know what any +of that meant, and in fact Watson was totally unaware that it had won at +all. All the hype aside, the truth is that Watson is a highly sophisticated +adding machine, able to add (or search data files) billions of times faster +than the human brain, but it is totally lacking in self-awareness or +common sense. + +On one hand, progress in artificial intelligence has been astounding, +especially in the area of raw computational power. Someone from the +year 1900, viewing the calculations performed by computers today, +would consider these machines to be miracles. But in another sense, +progress has been painstakingly slow in building machines that can think +for themselves (i.e., true automatons, without a puppet master, a +controller with a joystick, or someone with a remote-control panel). + +Robots are totally unaware that they are robots." +"Robots are totally unaware that they are robots. + +Given the fact that computer power has been doubling every two years +for the past fifty years under Moore’s law, some say it is only a matter of +time before machines eventually acquire self-awareness that rivals +human intelligence. No one knows when this will happen, but humanity +should be prepared for the moment when machine consciousness leaves +the laboratory and enters the real world. How we deal with robot +consciousness could decide the future of the human race. + +BOOM AND BUST CYCLES IN AI" +"BOOM AND BUST CYCLES IN AI + +It is difficult to foretell the fate of AI, since it has gone through three +cycles of boom and bust. Back in the 1950s, it seemed as if mechanical +maids and butlers were just around the corner. Machines were being +built that could play checkers and solve algebra problems. Robot arms +were developed that could recognize and pick up blocks. At Stanford +University, a robot was built called Shakey—basically a computer sitting +on top of wheels with a camera—which could wander around a room by +itself, avoiding obstacles." +"Breathless articles were soon published in science magazines heralding +the coming of the robot companion. Some predictions were too +conservative. In 1949, Popular Mechanics stated that “in the future, +computers will weigh no more than 1.5 tons.” But others were wildly +optimistic in proclaiming that the day of the robots was near. Shakey +would one day become a mechanical maid or butler that would vacuum +our carpets and open our doors. Movies like 2001: A Space Odyssey +convinced us that robots would soon be piloting our rocket ships to +Jupiter and chatting with our astronauts. In 1965, Dr. Herbert Simon, + + one of the founders of AI, said flatly, “Machines will be capable, within +20 years, of doing any work a man can do.” Two years later, another +founding father of AI, Dr. Marvin Minsky, said that “within a +generation ... the problem of creating ‘artificial intelligence’ will +substantially be solved.”" +"But all this unbounded optimism collapsed in the 1970s. Checker¬ +playing machines could only play checkers, nothing more. Mechanical +arms could pick up blocks, but nothing else. They were like one-trick + +ponies. The most advanced robots took hours just to walk across a room. +Shakey, placed in an unfamiliar environment, would easily get lost. And +scientists were nowhere near understanding consciousness. In 1974, AI +suffered a huge blow when both the U.S. and British governments +substantially curtailed funding in the field." +"But as computer power steadily increased in the 1980s, a new gold +rush occurred in AI, fueled mainly by Pentagon planners hoping to put +robot soldiers on the battlefield. Funding for AI hit a billion dollars by +1985, with hundreds of millions of dollars spent on projects like the +Smart Truck, which was supposed to be an intelligent, autonomous truck +that could enter enemy lines, do reconnaissance by itself, perform +missions (such as rescuing prisoners), and then return to friendly +territory. Unfortunately, the only thing that the Smart Truck did was get +lost. The visible failures of these costly projects created yet another AI +winter in the 1990s. + +Paul Abrahams, commenting about the years he spent at MIT as a +graduate student, has said, “It’s as though a group of people had +proposed to build a tower to the moon. Each year, they point with pride +at how much higher the tower is than it was the previous year. The only +trouble is that the moon isn’t getting much closer.”" +"But now, with the relentless march of computer power, a new AI +renaissance has begun, and slow but substantial progress has been made. +In 1997, IBM’s Deep Blue computer beat world chess champion Garry +Kasparov. In 2005, a robot car from Stanford won the DARPA Grand +Challenge for a driverless car. Milestones continue to be reached. + +This question remains: Is the third try the charm? + +Scientists now realize that they vastly underestimated the problem, +because most human thought is actually subconscious. The conscious +part of our thoughts, in fact, represents only the tiniest portion of our +computations. + +Dr. Steve Pinker says, “I would pay a lot for a robot that would put + + away the dishes or run simple errands, but I can’t, because all of the +little problems that you’d need to solve to build a robot do to that, like +recognizing objects, reasoning about the world, and controlling hands +and feet, are unsolved engineering problems.”" +"Although Hollywood movies tell us that terrifying Terminator robots +may be just around the corner, the task of creating an artificial mind has + +been much more difficult than previously thought. I once asked Dr. +Minsky when machines would equal and perhaps even surpass human +intelligence. He said that he was confident this would happen but that +he doesn’t make predictions about dates anymore. Given the roller¬ +coaster history of AI, perhaps this is the wisest approach, to map out the +future of AI without setting a specific timetable. + +PATTERN RECOGNITION AND COMMON SENSE + +There are at least two basic problems confronting AI: pattern recognition +and common sense." +"There are at least two basic problems confronting AI: pattern recognition +and common sense. + +Our best robots can barely recognize simple objects like a cup or a +ball. The robot’s eye may see details better than a natural eye, but the +robot brain cannot recognize what it is seeing. If you place a robot on a +strange, busy street, it quickly becomes disoriented and gets lost. Pattern +recognition (e.g., identifying objects) has progressed much more slowly +than previously estimated because of this problem." +"When a robot walks into a room, it has to perform trillions of +calculations, breaking down the objects it sees into pixels, lines, circles, +squares, and triangles, and then trying to make a match with the +thousands of images stored in its memory. For instance, robots see a +chair as a hodgepodge of lines and dots, but they cannot easily identify +the essence of “chairness.” Even if a robot is able to successfully match +an object to an image in its database, a slight rotation (like a chair that’s +been knocked over on the floor) or change in perspective (viewing the +chair from a different angle) will mystify the robot. Our brains, however, +automatically take different perspectives and variations into account. +Our brains are subconsciously performing trillions of calculations, but +the process seems effortless to us." +"Robots also have a problem with common sense. They do not +understand simple facts about the physical and biological world. There +isn’t an equation that can confirm something as self-evident (to us +humans) as “muggy weather is uncomfortable” or “mothers are older +than their daughters.” There has been some progress made in translating + + this sort of information into mathematical logic, but to catalog the +common sense of a four-year-old child would require hundreds of + +millions of lines of computer code. As Voltaire once said, “Common +sense is not so common.” + +For example, one of our most advanced robots is called ASIMO, built +in Japan (where 30 percent of all industrial robots are made) by the +Honda Corporation. This marvelous robot, about the size of a young boy, +can walk, run, climb stairs, speak different languages, and dance (much +better than I do, in fact). I have interacted with ASIMO on TV several +times, and was very impressed by its abilities." +"However, I met privately with the creators of ASIMO and asked them +this key question: How smart is ASIMO, if we compare it to an animal? +They admitted to me that it has the intelligence of a bug. All the walking +and talking is mostly for the press. The problem is that ASIMO is, by and +large, a big tape recorder. It has only a modest list of truly autonomous +functions, so almost every speech or motion has to be carefully scripted +ahead of time. For example, it took about three hours to film a short +sequence of me interacting with ASIMO, because the hand gesture and +other movement had to be programmed by a team of handlers." +"If we consider this in relation to our definition of human +consciousness, it seems that our current robots are stuck at a very +primitive level, simply trying to make sense of the physical and social +world by learning basic facts. As a consequence, robots are not even at +the stage where they can plot realistic simulations of the future. Asking a +robot to craft a plan to rob a bank, for instance, assumes that the robot +knows all the fundamentals about banks, such as where the money is +stored, what sort of security system is in place, and how the police and +bystanders will react to the situation. Some of this can be programmed, +but there are hundreds of nuances that the human mind naturally +understands but robots do not." +"Where robots excel is in simulating the future in just one precise field, +such as playing chess, modeling the weather, tracing the collision of +galaxies, etc. Since the laws of chess and gravity have been well known +for centuries, it is only a matter of raw computer power to simulate the +future of a chess game or a solar system. + +Attempts to move beyond this level using brute force have also +floundered. One ambitious program, called CYC, was designed to solve +the commonsense problem. CYC would include millions of lines of +computer code containing all the information of common sense and + + knowledge necessary to understand its physical and social environment. +Although CYC can process hundreds of thousands of facts and millions of +statements, it still cannot reproduce the level of thought of a four-year- +old human. Unfortunately, after some optimistic press releases, the effort +has stagnated. Many of its programmers left, deadlines have come and +gone, and yet the project still continues." +"IS THE BRAIN A COMPUTER? + +Where did we go wrong? For the past fifty years, scientists working in AI +have tried to model the brain by following the analogy with digital +computers. But perhaps this was too simplistic. As Joseph Campbell once +said, “Computers are like Old Testament gods; lots of rules and no +mercy.” If you remove a single transistor from a Pentium chip, the +computer will crash immediately. But the human brain can perform +quite well even if half of it is missing." +"This is because the brain is not a digital computer at all, but a highly +sophisticated neural network of some sort. Unlike a digital computer, +which has a fixed architecture (input, output, and processor), neural +networks are collections of neurons that constantly rewire and reinforce +themselves after learning a new task. The brain has no programming, no +operating system, no Windows, no central processor. Instead, its neural +networks are massively parallel, with one hundred billion neurons firing +at the same time in order to accomplish a single goal: to learn." +"In light of this, AI researchers are beginning to reexamine the “top- +down approach” they have followed for the last fifty years (e.g., putting +all the rules of common sense on a CD). Now AI researchers are giving +the “bottom-up approach” a second look. This approach tries to follow +Mother Nature, which has created intelligent beings (us) via evolution, +starting with simple animals like worms and fish and then creating more +complex ones. Neural networks must learn the hard way, by bumping +into things and making mistakes. + +Dr. Rodney Brooks, former director of the famed MIT Artificial +Intelligence Laboratory, and cofounder of iRobot, which makes those +mechanical vacuum cleaners found in many living rooms, introduced an +entirely new approach to AI. Instead of designing big, clumsy robots," +"why not build small, compact, insectlike robots that have to learn how +to walk, just as in nature?When I interviewed him, he told me that he +used to marvel at the mosquito, which had a nearly microscopic brain +with very few neurons, yet was able to maneuver in space better than + + any robot airplane. He built a series of remarkably simple robots, +affectionately called “insectoids” or “bugbots,” which scurried around +the floors of MIT and could run circles around the more traditional +robots. The goal was to create robots that follow the trial-and-error +method of Mother Nature. In other words, these robots learn by bumping +into things. + +(At first, it may seem that this requires a lot of programming. The +irony, however, is that neural networks require no programming at all. +The only thing that the neural network does is rewire itself, by changing +the strength of certain pathways each time it makes a right decision. So +programming is nothing; changing the network is everything.)" +"Science-fiction writers once envisioned that robots on Mars would be +sophisticated humanoids, walking and moving just like us, with complex +programming that gave them human intelligence. The opposite has +happened. Today the grandchildren of this approach—like the Mars +Curiosity rover—are now roaming over the surface of Mars. They are not +programmed to walk like a human. Instead, they have the intelligence of +a bug, but they do quite fine in this terrain. These Mars rovers have +relatively little programming; instead, they learn as they bump into +obstacles. + +ARE ROBOTS CONSCIOUS?" +"ARE ROBOTS CONSCIOUS? + +Perhaps the clearest way to see why true robot automatons do not yet +exist is to rank their level of consciousness. As we have seen in Chapter +2, we can rank consciousness in four levels. Level 0 consciousness +describes thermostats and plants; that is, it involves a few feedback loops +in a handful of simple parameters such as temperature or sunlight. Level +I consciousness describes insects and reptiles, which are mobile and have +a central nervous system; it involves creating a model of your world in +relationship to a new parameter, space. Then we have Level II +consciousness, which creates a model of the world in relationship to + +others of its kind, requiring emotions. Finally we have Level III +consciousness, which describes humans, who incorporate time and self- +awareness to simulate how things will evolve in the future and +determine our own place in these models." +"We can use this theory to rank the robots of today. The first +generation of robots were at Level 0, since they were static, without +wheels or treads. Today’s robots are at Level I, since they are mobile, but +they are at a very low echelon because they have tremendous difficulty +navigating in the real world. Their consciousness can be compared to +that of a worm or slow insect. To fully produce Level I consciousness, + + scientists will have to create robots that can realistically duplicate the +consciousness of insects and reptiles. Even insects have abilities that +current robots do not have, such as rapidly finding hiding places, +locating mates in the forest, recognizing and evading predators, or +finding food and shelter." +"As we mentioned earlier, we can numerically rank consciousness by +the number of feedback loops at each level. Robots that can see, for +example, may have several feedback loops because they have visual +sensors that can detect shadows, edges, curves, geometric shapes, etc., in +three-dimensional space. Similarly, robots that can hear require sensors +that can detect frequency, intensity, stress, pauses, etc. The total number +of these feedback loops may total ten or so (while an insect, because it +can forage in the wild, find mates, locate shelter, etc., may have fifty or +more feedback loops). A typical robot, therefore, may have Level 1:10 +consciousness." +"Robots will have to be able to create a model of the world in relation +to others if they are to enter Level II consciousness. As we mentioned +before, Level II consciousness, to a first approximation, is computed by +multiplying the number of members of its group times the number of +emotions and gestures that are used to communicate between them. +Robots would thus have a consciousness of Level 11:0. But hopefully, the +emotional robots being built in labs today may soon raise that number. + +Current robots view humans as simply a collection of pixels moving on +their TV sensors, but some AI researchers are beginning to create robots +that can recognize emotions in our facial expressions and tone of voice. +This is a first step toward robots’ realizing that humans are more than +just random pixels, and that they have emotional states." +"In the next few decades, robots will gradually rise in Level II +consciousness, becoming as intelligent as a mouse, rat, rabbit, and then a +cat. Perhaps late in this century, they will be as intelligent as a monkey, +and will begin to create goals of their own. + +Once robots have a working knowledge of common sense and the +Theory of Mind, they will be able to run complex simulations into the +future featuring themselves as the principal actors and thus enter Level +III consciousness. They will leave the world of the present and enter the +world of the future. This is many decades beyond the capability of any +robot today. Running simulations of the future means that you have a +firm grasp of the laws of nature, causality, and common sense, so that +you can anticipate future events. It also means that you understand +human intentions and motivations, so you can predict their future +behavior as well." +"The numerical value of Level III consciousness, as we mentioned, is +calculated by the total number of causal links one can make in +simulating the future in a variety of real-life situations, divided by the +average value of a control group. Computers today are able to make +limited simulations in a few parameters (e.g., the collision of two +galaxies, the flow of air around an airplane, the shaking of buildings in +an earthquake), but they are totally unprepared to simulate the future in +complex, real-life situations, so their level of consciousness would be +something like Level III: 5. + +As we can see, it may take many decades of hard work before we have +a robot that can function normally in human society. + +SPEED BUMPS ON THE WAY" +"SPEED BUMPS ON THE WAY + +So when might robots finally match and exceed humans in intelligence? +No one knows, but there have been many predictions. Most of them rely +on Moore’s law extending decades into the future. However, Moore’s law +is not a law at all, and in fact it ultimately violates a fundamental +physical law: the quantum theory. + +As such, Moore’s law cannot last forever. In fact, we can already see it +slowing down now. It might flatten out by the end of this or the next +decade, and the consequences could be dire, especially for Silicon Valley." +"The problem is simple. Right now, you can place hundreds of millions +of silicon transistors on a chip the size of your fingernail, but there is a +limit to how much you can cram onto these chips. Today the smallest +layer of silicon in your Pentium chip is about twenty atoms in width, +and by 2020 that layer might be five atoms across. But then Heisenberg’s +uncertainty principle kicks in, and you wouldn’t be able to determine +precisely where the electron is and it could “leak out” of the wire. (See +the Appendix, where we discuss the quantum theory and the uncertainty +principle in more detail.) The chip would short-circuit. In addition, it +would generate enough heat to fry an egg on it. So leakage and heat will +eventually doom Moore’s law, and a replacement will soon be necessary." +"If packing transistors on flat chips is maxing out in computing power, +Intel is making a multibillion-dollar bet that chips will rise into the third +dimension. Time will tell if this gamble pays off (one major problem +with 3-D chips is that the heat generated rises rapidly with the height of +the chip). + +Microsoft is looking into other options, such as expanding into 2-D +with parallel processing. One possibility is to spread chips horizontally + + in a row. Then you break up a software problem into pieces, sort out +each piece on a small chip, and reassemble it at the end. However, it +may be a difficult process, and software grows at a much slower pace +than the supercharged exponential rate we are accustomed to with +Moore’s law." +"These stopgap measures may add years to Moore’s law. But eventually, +all this must pass, too: the quantum theory inevitably takes over. This +means that physicists are experimenting with a wide variety of +alternatives after the Age of Silicon draws to a close, such as quantum +computers, molecular computers, nanocomputers, DNA computers, +optical computers, etc. None of these technologies, however, is ready for +prime time. + +THE UNCANNY VALLEY + +But assume for the moment that one day we will coexist with incredibly +sophisticated robots, perhaps using chips with molecular transistors +instead of silicon. How closely do we want our robots to look like us?" +"Japan is the world’s leader in creating robots that resemble cuddly pets +and children, but their designers are careful not to make their robots +appear too human, which can be unnerving. This phenomenon was first +studied by Dr. Masahiro Mori in Japan in 1970, and is called the +“uncanny valley.” It posits that robots look creepy if they look too much +like humans. (The effect was actually first mentioned by Darwin in 1839 +in The Voyage of the Beagle and again by Freud in 1919 in an essay titled +“The Uncanny.”) Since then, it has been studied very carefully not just +by AI researchers but also by animators, advertisers, and anyone +promoting a product involving humanlike figures. For instance, in a +review of the movie The Polar Express, a CNN writer noted, “Those +human characters in the film come across as downright ... well, creepy. +So The Polar Express is at best disconcerting, and at worst, a wee bit +horrifying.”" +"According to Dr. Mori, the more a robot looks like a human, the more +we feel empathy toward it, but only up to a point. There is a dip in +empathy as the robot approaches actual human appearance—hence the +uncanny valley. If the robot looks very similar to us save for a few +features that are “uncanny,” it creates a feeling of revulsion and fear. If +the robot appears 100 percent human, indistinguishable from you and +me, then we’ll register positive emotions again. + +This has practical implications. For example, should robots smile? At +first, it seems obvious that robots should smile to greet people and make" +"them feel comfortable. Smiling is a universal gesture that signals warmth +and welcome. But if the robot smile is too realistic, it makes people’s +skin crawl. (For example, Halloween masks often feature fiendish- +looking ghouls that are grinning.) So robots should smile only if they are +childlike (i.e., with big eyes and a round face) or are perfectly human, +and nothing in between. (When we force a smile, we activate facial +muscles with our prefrontal cortex. But when we smile because we are in +a good mood, our nerves are controlled by our limbic system, which +activates a slightly different set of muscles. Our brains can tell the subtle +difference between the two, which was beneficial for our evolution.) + +This effect can also be studied using brain scans. Let’s say that a +subject is placed into an MRI machine and is shown a picture of a robot +that looks perfectly human, except that its bodily motions are slightly +jerky and mechanical. The brain, whenever it sees anything, tries to" +"predict that object’s motion into the future. So when looking at a robot +that appears to be human, the brain predicts that it will move like a +human. But when the robot moves like a machine, there is a mismatch, +which makes us uncomfortable. In particular, the parietal lobe lights up +(specifically, the part of the lobe where the motor cortex connects with +the visual cortex). It is believed that mirror neurons exist in this area of +the parietal lobe. This makes sense, because the visual cortex picks up +the image of the humanlike robot, and its motions are predicted via the +motor cortex and by mirror neurons. Finally, it is likely that the +orbitofrontal cortex, located right behind the eyes, puts everything +together and says, “Hmmm, something is not quite right.”" +"Hollywood filmmakers are aware of this effect. When spending +millions on making a horror movie, they realize that the scariest scene is +not when a gigantic blob or Frankenstein’s monster pounces out of the +bushes. The scariest scene is when there is a perversion of the ordinary. +Think of the movie The Exorcist What scene made moviegoers vomit as +they ran to escape the theater or faint right in their seats? Was it the +scene when a demon appears? No. Theaters across the world erupted in +shrill screams and loud sobs when Linda Blair turned her head +completely around." +"This effect can also be demonstrated in young monkeys. If you show +them pictures of Dracula or Frankenstein, they simply laugh and rip the +pictures apart. But what sends these young monkeys screaming in terror +is a picture of a decapitated monkey. Once again, it is the perversion of +the ordinary that elicits the greatest fear. (In Chapter 2, we mentioned +that the space-time theory of consciousness explains the nature of +humor, since the brain simulates the future of a joke, and then is +surprised to hear the punch line. This also explains the nature of horror. +The brain simulates the future of an ordinary, mundane event, but then + + is shocked when things suddenly become horribly perverted.) + +For this reason, robots will continue to look somewhat childlike in +appearance, even as they approach human intelligence. Only when +robots can act realistically like humans will their designers make them +look fully human. + +SILICON CONSCIOUSNESS" +"SILICON CONSCIOUSNESS + +As we’ve seen, human consciousness is an imperfect patchwork of +different abilities developed over millions of years of evolution. Given +information about their physical and social world, robots may be able to +create simulations similar (or in some respects, even superior) to ours, +but silicon consciousness might differ from ours in two key areas: +emotions and goals. + +Historically, AI researchers ignored the problem of emotions, +considering it a secondary issue. The goal was to create a robot that was +logical and rational, not scatterbrained and impulsive. Hence, the +science fiction of the 1950s and ’60s stressed robots (and humanoids like +Spock on Star Trek ) that had perfect, logical brains." +"We saw with the uncanny valley that robots will have to look a certain +way if they’re to enter our homes, but some people argue that robots +must also have emotions so that we can bond with, take care of, and +interact productively with them. In other words, robots will need Level II +consciousness. To accomplish this, robots will first have to recognize the +full spectrum of human emotions. By analyzing subtle facial movements +of the eyebrows, eyelids, lips, cheeks, etc., a robot will be able to +identify the emotional state of a human, such as its owner. One +institution that has excelled in creating robots that recognize and mimic +emotion is the MIT Media Laboratory. I have had the pleasure of visiting +the laboratory, outside Boston, on several occasions, and it is like +visiting a toy factory for grown-ups. Everywhere you look, you see +futuristic, high-tech devices designed to make our lives more interesting, +enjoyable, and convenient." +"As I looked around the room, I saw many of the high-tech graphics +that eventually found their way into Hollywood movies like Minority +Report and AI. As I wandered through this playground of the future, I +came across two intriguing robots, Huggable and Nexi. Their creator, Dr. +Cynthia Breazeal, explained to me that these robots have specific goals. +Huggable is a cute teddy bear-like robot that can bond with children. It +can identify the emotions of children; it has video cameras for eyes, a +speaker for its mouth, and sensors in its skin (so it can tell when it is +being tickled, poked, or hugged). Eventually, a robot like this might +become a tutor, babysitter, nurse’s aide, or a playmate. + + Nexi, on the other hand, can bond with adults. It looks a little like the +Pillsbury Doughboy. It has a round, puffy, friendly face, with large eyes" +"that can roll around. It has already been tested in a nursing home, and +the elderly patients all loved it. Once the seniors got accustomed to Nexi, +they would kiss it, talk to it, and miss it when it had to leave. (See +Figure 12.) + +Dr. Breazeal told me she designed Huggable and Nexi because she was +not satisfied with earlier robots, which looked like tin cans full of wires, +gears, and motors. In order to design a robot that could interact +emotionally with people, she needed to figure out how she could get it +to perform and bond like us. Plus, she wanted robots that weren’t stuck +on a laboratory shelf but could venture out into the real world. The +former director of MIT’s Media Lab, Dr. Frank Moss, says, “That is why +Breazeal decided in 2004 that it was time to create a new generation of +social robots that could live anywhere: homes, schools, hospitals, elder +care facilities, and so on.”" +"At Waseda University in Japan, scientists are working on a robot that +has upper-body motions representing emotions (fear, anger, surprise, +joy, disgust, sadness) and can hear, smell, see, and touch. It has been +programmed to carry out simple goals, such as satisfying its hunger for +energy and avoiding dangerous situations. Their goal is to integrate the +senses with the emotions, so that the robot acts appropriately in +different situations. + +Figure 12. Huggable (top) and Nexi (bottom), two robots built at the MIT Media Laboratory that were +explicitly designed + +to interact with humans via emotions, (illustration credit 10.1) + +(illustration credit 10.2) + +Not to be outdone, the European Commission is funding an ongoing +project, called Feelix Growing, which seeks to promote artificial +intelligence in the UK, France, Switzerland, Greece, and Denmark. + +EMOTIONAL ROBOTS + + Meet Nao." +"EMOTIONAL ROBOTS + + Meet Nao. + +When he’s happy, he will stretch out his arms to greet you, wanting a +big hug. When he’s sad, he turns his head downward and appears +forlorn, with his shoulders hunched forward. When he’s scared, he +cowers in fear, until someone pats him reassuringly on the head. + +He’s just like a one-year-old boy, except that he’s a robot. Nao is about +one and a half feet tall, and looks very much like some of the robots you +see in a toy store, like the Tranformers, except he’s one of the most +advanced emotional robots on earth. He was built by scientists at the + +UK’s University of Hertfordshire, whose research was funded by the +European Union. + +His creators have programmed him to show emotions like happiness, +sadness, fear, excitement, and pride. While other robots have +rudimentary facial and verbal gestures that communicate their emotions, +Nao excels in body language, such as posture and gesture. Nao even +dances." +"Unlike other robots, which specialize in mastering just one area of the +emotions, Nao has mastered a wide range of emotional responses. First, +Nao locks onto visitors’ faces, identifies them, and remembers his +previous interactions with each of them. Second, he begins to follow +their movements. For example, he can follow their gaze and tell what +they are looking at. Third, he begins to bond with them and learns to +respond to their gestures. For example, if you smile at him, or pat him +on his head, he knows that this is a positive sign. Because his brain has +neural networks, he learns from interactions with humans. Fourth, Nao +exhibits emotions in response to his interactions with people. (His +emotional responses are all preprogrammed, like a tape recorder, but he +decides which emotion to choose to fit the situation.) And lastly, the +more Nao interacts with a human, the better he gets at understanding +the moods of that person and the stronger the bond becomes." +"Not only does Nao have a personality, he can actually have several of +them. Because he learns from his interactions with humans and each +interaction is unique, eventually different personalities begin to emerge. +For example, one personality might be quite independent, not requiring +much human guidance. Another personality might be timid and fearful, +scared of objects in a room, constantly requiring human intervention. + +The project leader for Nao is Dr. Lola Canamero, a computer scientist +at the University of Hertfordshire. To start this ambitious project, she +analyzed the interactions of chimpanzees. Her goal was to reproduce, as +closely as she could, the emotional behavior of a one-year-old + + chimpanzee." +"chimpanzee. + +She sees immediate applications for these emotional robots. Like Dr. +Breazeal, she wants to use these robots to relieve the anxiety of young +children who are in hospitals. She says, “We want to explore different +roles—the robots will help the children to understand their treatment, +explain what they have to do. We want to help the children to control + +their anxiety.” + +Another possibility is that the robots will become companions at +nursing homes. Nao could become a valuable addition to the staff of a +hospital. At some point, robots like these might become playmates to +children and a part of the family." +"“It’s hard to predict the future, but it won’t be too long before the +computer in front of you will be a social robot. You’ll be able to talk to +it, flirt with it, or even get angry and yell at it—and it will understand +you and your emotions,” says Dr. Terrence Sejnowski of the Salk +Institute, near San Diego. This is the easy part. The hard part is to gauge +the response of the robot, given this information. If the owner is angry +or displeased, the robot has to be able to factor this into its response. + +EMOTIONS: DETERMINING WHAT IS IMPORTANT" +"EMOTIONS: DETERMINING WHAT IS IMPORTANT + +What’s more, AI researchers have begun to realize that emotions may be +a key to consciousness. Neuroscientists like Dr. Antonio Damasio have +found that when the link between the prefrontal lobe (which governs +rational thought) and the emotional centers (e.g., the limbic system) is +damaged, patients cannot make value judgments. They are paralyzed +when making the simplest of decisions (what things to buy, when to set +an appointment, which color pen to use) because everything has the +same value to them. Hence, emotions are not a luxury; they are +absolutely essential, and without them a robot will have difficulty +determining what is important and what is not. So emotions, instead of +being peripheral to the progress of artificial intelligence, are now +assuming central importance." +"If a robot encounters a raging fire, it might rescue the computer files +first, not the people, since its programming might say that valuable +documents cannot be replaced but workers always can be. It is crucial +that robots be programmed to distinguish between what is important +and what is not, and emotions are shortcuts the brain uses to rapidly +determine this. Robots would thus have to be programmed to have a +value system—that human life is more important than material objects, + + that children should be rescued first in an emergency, that objects with a +higher price are more valuable than objects with a lower price, etc. Since + +robots do not come equipped with values, a huge list of value judgments +must be uploaded into them." +"The problem with emotions, however, is that they are sometimes +irrational, while robots are mathematically precise. So silicon +consciousness may differ from human consciousness in key ways. For +example, humans have little control over emotions, since they happen so +rapidly and because they originate in the limbic system, not the +prefrontal cortex of the brain. Furthermore, our emotions are often +biased. Numerous tests have shown that we tend to overestimate the +abilities of people who are handsome or pretty. Good-looking people +tend to rise higher in society and have better jobs, although they may +not be as talented as others. As the expression goes, “Beauty has its +privileges.”" +"Similarly, silicon consciousness may not take into account subtle cues +that humans use when they meet one another, such as body language. +When people enter a room, young people usually defer to older ones and +low-ranked staff members show extra courtesy to senior officials. We +show our deference in the way we move our bodies, our choice of words, +and our gestures. Because body language is older than language itself, it +is hardwired into the brain in subtle ways. Robots, if they are to interact +socially with people, will have to learn these unconscious cues. + +Our consciousness is influenced by peculiarities in our evolutionary +past, which robots will not have, so silicon consciousness may not have +the same gaps or quirks as ours. + +A MENU OF EMOTIONS + +Since emotions have to be programmed into robots from the outside, +manufacturers may offer a menu of emotions carefully chosen on the +basis of whether they are necessary, useful, or will increase bonding +with the owner." +"In all likelihood, robots will be programmed to have only a few +human emotions, depending on the situation. Perhaps the emotion most +valued by the robot’s owner will be loyalty. One wants a robot that +faithfully carries out its commands without complaints, that understands +the needs of the master and anticipates them. The last thing an owner + + will want is a robot with an attitude, one that talks back, criticizes +people, and whines. Helpful criticisms are important, but they must be +made in a constructive, tactful way. Also, if humans give it conflicting +commands, the robot should know to ignore all of them except those +coming from its owner. + +Empathy will be another emotion that will be valued by the owner. +Robots that have empathy will understand the problems of others and +will come to their aid. By interpreting facial movements and listening to +tone of voice, robots will be able to identify when a person is in distress +and will provide assistance when possible." +"Strangely, fear is another emotion that is desirable. Evolution gave us +the feeling of fear for a reason, to avoid certain things that are +dangerous to us. Even though robots will be made of steel, they should +fear certain things that can damage them, like falling off tall buildings or +entering a raging fire. A totally fearless robot is a useless one if it +destroys itself. + +But certain emotions may have to be deleted, forbidden, or highly +regulated, such as anger. Given that robots could be built to have great +physical strength, an angry robot could create tremendous problems in +the home and workplace. Anger could get in the way of its duties and +cause great damage to property. (The original evolutionary purpose of +anger was to show our dissatisfaction. This can be done in a rational, +dispassionate way, without getting angry.)" +"Another emotion that should be deleted is the desire to be in +command. A bossy robot will only make trouble and might challenge the +judgment and wishes of the owner. (This point will also be important +later, when we discuss whether robots will one day take over from +humans.) Hence the robot will have to defer to the wishes of the owner, +even if this may not be the best path. + +But perhaps the most difficult emotion to convey is humor, which is a +glue that can bond total strangers together. A simple joke can defuse a +tense situation or inflame it. The basic mechanics of humor are simple: +they involve a punch line that is unanticipated. But the subtleties of +humor can be enormous. In fact, we often size up other people on the +basis of how they react to certain jokes. If humans use humor as a gauge +to measure other humans, then one can appreciate the difficulty of +creating a robot that can tell if a joke is funny or not. President Ronald" +"Reagan, for example, was famous for defusing the most difficult +questions with a quip. In fact, he accumulated a large card catalog of +jokes, barbs, and wisecracks, because he understood the power of + + humor. (Some pundits concluded that he won the presidential debate +against Walter Mondale when he was asked if he was too old to be +president. Reagan replied that he would not hold the youth of his +opponent against him.) Also, laughing inappropriately could have +disastrous consequences (and is, in fact, sometimes a sign of mental +illness). The robot has to know the difference between laughing with or +at someone. (Actors are well aware of the diverse nature of laughter. +They are skilled enough to create laughter that can represent horror, +cynicism, joy, anger, sadness, etc.) So, at least until the theory of +artificial intelligence becomes more developed, robots should stay away +from humor and laughter. + +PROGRAMMING EMOTIONS" +"PROGRAMMING EMOTIONS + +In this discussion we have so far avoided the difficult question of +precisely how these emotions would be programmed into a computer. +Because of their complexity, emotions will probably have to be +programmed in stages. + +First, the easiest part is identifying an emotion by analyzing the +gestures in a person’s face, lips, eyebrows, and tone of voice. Today’s +facial recognition technology is already capable of creating a dictionary +of emotions, so that certain facial expressions mean certain things. This +process actually goes back to Charles Darwin, who spent a considerable +amount of time cataloging emotions common to animals and humans. + +Second, the robot must respond rapidly to this emotion. This is also +easy. If someone is laughing, the robot will grin. If someone is angry, the +robot will get out of his way and avoid conflict. The robot would have a +large encyclopedia of emotions programmed into it, and hence would +know how to make a rapid response to each one." +"The third stage is perhaps the most complex because it involves trying +to determine the underlying motivation behind the original emotion. +This is difficult, since a variety of situations can trigger a single emotion. +Laughter may mean that someone is happy, heard a joke, or watched + +someone fall. Or it might mean that a person is nervous, anxious, or +insulting someone. Likewise, if someone is screaming, there may be an +emergency, or perhaps someone is just reacting with joy and surprise. +Determining the reason behind an emotion is a skill that even humans +have difficulty with. To do this, the robot will have to list the various +possible reasons behind an emotion and try to determine the reason that +makes the most sense. This means trying to find a reason behind the +emotion that fits the data best." +"And fourth, once the robot has determined the origin of this emotion, +it has to make the appropriate response. This is also difficult, since there +are often several possible responses, and the wrong one may make the +situation worse. The robot already has, within its programming, a list of +possible responses to the original emotion. It has to calculate which one +will best serve the situation, which means simulating the future. + +WILL ROBOTS LIE? + +Normally, we might think of robots as being coldly analytical and +rational, always telling the truth. But once robots become integrated into +society, they will probably have to learn to lie or at least tactfully +restrain their comments." +"In our own lives, several times in a typical day we are confronted with +situations where we have to tell a white lie. If people ask us how they +look, we often dare not tell the truth. White lies, in fact, are like a grease +that makes society run smoothly. If we were suddenly forced to tell the +whole truth (like Jim Carrey in Liar Liar), we most likely would wind up +creating chaos and hurting people. People would be insulted if you told +them what they really looked like or how you really felt. Bosses would +fire you. Lovers would dump you. Friends would abandon you. Strangers +would slap you. Some thoughts are better kept confidential." +"In the same way, robots may have to learn how to lie or conceal the +truth, or else they might wind up offending people and being +decommissioned by their owners. At a party, if a robot tells the truth, it +could reflect badly on its owner and create an uproar. So if someone asks +for its opinion, it will have to learn how to be evasive, diplomatic, and +tactful. It must either dodge the question, change the subject, give + +platitudes for answers, reply with a question, or tell white lies (all things +that today’s chat-bots are increasingly good at). This means that the +robot has already been programmed to have a list of possible evasive +responses, and must choose the one that creates the fewest +complications." +"One of the few times that a robot would tell the entire truth would be +if asked a direct question by its owner, who understands that the answer +might be brutally honest. Perhaps the only other time when the robot +will tell the truth is when there is a police investigation and the absolute +truth is necessary. Other than that, robots will be able to freely lie or +conceal the whole truth to keep the wheels of society functioning. + + In other words, robots have to be socialized, just like teenagers. + +CAN ROBOTS FEEL PAIN? + +Robots, in general, will be assigned to do types of tasks that are dull, +dirty, and dangerous. There is no reason why robots can’t do repetitive +or dirty jobs indefinitely, since we wouldn’t program them to feel +boredom or disgust. The real problem emerges when robots are faced +with dangerous jobs. At that point, we might actually want to program +them to feel pain." +"We evolved the sense of pain because it helped us survive in a +dangerous environment. There is a genetic defect in which children are +born without the ability to feel pain. This is called congenital analgesia. +At first glance, this may seem to be a blessing, since these children do +not cry when they experience injury, but it is actually more of a curse. +Children with this affliction have serious problems, such as biting off +parts of their tongue, suffering severe skin burns, and cutting +themselves, often leading to amputations of their fingers. Pain alerts us +to danger, telling us when to move our hand away from the burning +stove or to stop running on a twisted ankle." +"At some point robots must be programmed to feel pain, or else they +will not know when to avoid precarious situations. The first sense of +pain they must have is hunger (i.e., a craving for electrical energy). As +their batteries run out, they will get more desperate and urgent, +realizing that soon their circuits will shut down, leaving all their work in + +disarray. The closer they are to running out of power, the more anxious +they will become. + +Also, regardless of how strong they are, robots may accidentally pick +up an object that is too heavy, which could cause their limbs to break. +Or they may suffer overheating by working with molten metal in a steel +factory, or by entering a burning building to help firemen. Sensors for +temperature and stress would alert them that their design specifications +are being exceeded." +"But once the sensation of pain is added to their menu of emotions, this +immediately raises ethical issues. Many people believe that we should +not inflict unnecessary pain on animals, and people may feel the same +about robots as well. This opens the door to robots’ rights. Laws may +have to be passed to restrict the amount of pain and danger that a robot +is allowed to face. People will not care if a robot is performing dull or +dirty tasks, but if they feel pain doing a dangerous one, they may begin + + to lobby for laws to protect robots. This may even start a legal conflict, +with owners and manufacturers of robots arguing for increasing the level +of pain that robots can endure, while ethicists may argue for lowering it." +"This, in turn, may set off other ethical debates about other robot +rights. Can robots own property? What happens if they accidentally hurt +someone? Can they be sued or punished? Who is responsible in a +lawsuit? Can a robot own another robot? This discussion raises another +sticky question: Should robots be given a sense of ethics? + +ETHICAL ROBOTS + +At first, the idea of ethical robots seems like a waste of time and effort. +However, this question takes on a sense of urgency when we realize that +robots will make life-and-death decisions. Since they will be physically +strong and have the capability of saving lives, they will have to make +split-second ethical choices about whom to save first." +"Let’s say there is a catastrophic earthquake and children are trapped in +a rapidly crumbling building. How should the robot allocate its energy? +Should it try to save the largest number of children? Or the youngest? Or +the most vulnerable? If the debris is too heavy, the robot may damage its +electronics. So the robot has to decide yet another ethical question: How + +does it weigh the number of children it saves versus the amount of +damage that it will sustain to its electronics? + +Without proper programming, the robot may simply halt, waiting for a +human to make the final decision, wasting valuable time. So someone +will have to program it ahead of time so that the robot automatically +makes the “right” decision." +"These ethical decisions will have to be preprogrammed into the +computer from the start, since there is no law of mathematics that can +put a value on saving a group of children. Within its programming, there +has to be a long list of things, ranked in terms of how important they +are. This is tedious business. In fact, it sometimes takes a human a +lifetime to learn these ethical lessons, but a robot has to learn them +rapidly, before it leaves the factory, if it is to safely enter society. + +Only people can do this, and even then ethical dilemmas sometimes +confound us. But this raises questions: Who will make the decisions? +Who decides the order in which robots save human lives? + +The question of how decisions will ultimately be made will probably" +"The question of how decisions will ultimately be made will probably + + be resolved via a combination of the law and the marketplace. Laws will +have to be passed so that there is, at minimum, a ranking of importance +of whom to save in an emergency. But beyond that, there are thousands +of finer ethical questions. These subtler decisions may be decided by the +marketplace and common sense. + +If you work for a security firm guarding important people, you will +have to tell the robot how to save people in a precise order in different +situations, based on considerations such as fulfilling the primary duty +but also doing it within budget." +"What happens if a criminal buys a robot and wants the robot to +commit a crime? This raises a question: Should a robot be allowed to +defy its owner if it is asked to break the law? We saw from the previous +example that robots must be programmed to understand the law and +also make ethical decisions. So if it decides that it is being asked to +break the law, it must be allowed to disobey its master. + +There is also the ethical dilemma posed by robots reflecting the beliefs +of their owners, who may have diverging morals and social norms. The +“culture wars” that we see in society today will only be magnified when +we have robots that reflect the opinions and beliefs of their owners. In +some sense, this conflict is inevitable. Robots are mechanical extensions + +of the dreams and wishes of their creators, and when robots are +sophisticated enough to make moral decisions, they will do so." +"The fault lines of society may be stressed when robots begin to exhibit +behaviors that challenge our values and goals. Robots owned by youth +leaving a noisy, raucus rock concert may conflict with robots owned by +elderly residents of a quiet neighborhood. The first set of robots may be +programmed to amplify the sounds of the latest bands, while the second +set may be programmed to keep noise levels to an absolute minimum. +Robots owned by devout, churchgoing fundamentalists may get into +arguments with robots owned by atheists. Robots from different nations +and cultures may be designed to reflect the mores of their society, which +may clash (even for humans, let alone robots). + +So how does one program robots to eliminate these conflicts?" +"So how does one program robots to eliminate these conflicts? + +You can’t. Robots will simply reflect the biases and prejudices of their +creators. Ultimately, the cultural and ethical differences between these +robots will have to be settled in the courts. There is no law of physics or +science that determines these moral questions, so eventually laws will +have to be written to handle these social conflicts. Robots cannot solve +the moral dilemmas created by humans. In fact, robots may amplify +them. + + But if robots can make ethical and legal decisions, can they also feel +and understand sensations? If they succeed in saving someone, can they +experience joy? Or can they even feel things like the color red? Coldly +analyzing the ethics of whom to save is one thing, but understanding +and feeling is another. So can robots feel? + +CAN ROBOTS UNDERSTAND OR FEEL?" +"CAN ROBOTS UNDERSTAND OR FEEL? + +Over the centuries, a great many theories have been advanced about +whether a machine can think and feel. My own philosophy is called +“constructivism”; that is, instead of endlessly debating the question, +which is pointless, we should be devoting our energy to creating an +automaton to see how far we can get. Otherwise we wind up in endless +philosophical debates that are never ultimately resolved. The advantage +of science is that, once everything is said and done, one can perform +experiments to settle a question decisively." +"Thus, to settle the question of whether a robot can think, the final +resolution may be to build one. Some, however, have argued that +machines will never be able to think like a human. Their strongest +argument is that, although a robot can manipulate facts faster than a +human, it does not “understand” what it is manipulating. Although it +can process senses (e.g., color, sound) better than a human, it cannot +truly “feel” or “experience” the essence of these senses. + +For example, philosopher David Chalmers has divided the problems of +AI into two categories, the Easy Problems and the Hard Problems. To +him, the Easy Problems are creating machines that can mimic more and +more human abilities, such as playing chess, adding numbers, +recognizing certain patterns, etc. The Hard Problems involve creating +machines that can understand feelings and subjective sensations, which +are called “qualia.”" +"Just as it is impossible to teach the meaning of the color red to a blind +person, a robot will never be able to experience the subjective sensation +of the color red, they say. Or a computer might be able to translate +Chinese words into English with great fluency, but it will never be able +to understand what it is translating. In this picture, robots are like +glorified tape recorders or adding machines, able to recite and +manipulate information with incredible precision, but without any +understanding whatsoever. + +These arguments have to be taken seriously, but there is also another +way of looking at the question of qualia and subjective experience. In" +"the future, a machine most likely will be able to process a sensation, +such as the color red, much better than any human. It will be able to +describe the physical properties of red and even use it poetically in a +sentence better than a human. Does the robot “feel” the color red? The +point becomes irrelevant, since the word “feel” is not well defined. At +some point, a robot’s description of the color red may exceed a human’s, +and the robot may rightly ask: Do humans really understand the color +red? Perhaps humans cannot really understand the color red with all the +nuances and subtly that a robot can. + +As behaviorist B. F. Skinner once said, “The real problem is not +whether machines think, but whether men do.” + +Similarly, it is only a matter of time before a robot will be able to +define Chinese words and use them in context much better than any" +"human. At that point, it becomes irrelevant whether the robot +“understands” the Chinese language. For all practical purposes, the +computer will know the Chinese language better than any human. In +other words, the word “understand” is not well defined. + +One day, as robots surpass our ability to manipulate these words and +sensations, it will become irrelevant whether the robot “understands” or +“feels” them. The question will cease to have any importance. + +As mathematician John von Neumann said, “In mathematics, you +don’t understand things. You just get used to them.” + +So the problem lies not in the hardware but in the nature of human +language, in which words that are not well defined mean different things +to different people. The great quantum physicist Niels Bohr was once +asked how one could understand the deep paradoxes of the quantum +theory. The answer, he replied, lies in how you define the word +“understand.”" +"Dr. Daniel Dennett, a philosopher at Tufts University, has written, +“There could not be an objective test to distinguish a clever robot from a +conscious person. Now you have a choice: you can either cling to the +Hard Problem, or you can shake your head in wonder and dismiss it. +Just let go.” + +In other words, there is no such thing as the Hard Problem. + +To the constructivist philosophy, the point is not to debate whether a +machine can experience the color red, but to construct the machine. In +this picture, there is a continuum of levels describing the words +“understand” and “feel.” (This means that it might even be possible to" +"give numerical values to the degree of understanding and feeling.) At +one end we have the clumsy robots of today, which can manipulate a +few symbols but not much more. At the other end we have humans, who +pride themselves on feeling qualia. But as time goes by, robots will +eventually be able to describe sensations better than us on any level. +Then it will be obvious that robots understand. + +This was the philosophy behind Alan Turing’s famous Turing test. He +predicted that one day a machine would be built that could answer any +question, so that it would be indistinguishable from a human. He said, +“A computer would deserve to be called intelligent if it could deceive a +human into believing that it was human.” + +Physicist and Nobel laureate Francis Crick said it best. In the last" +"Physicist and Nobel laureate Francis Crick said it best. In the last + +century, he noted, biologists had heated debates over the question “What +is life?” Now, with our understanding of DNA, scientists realize that the +question is not well defined. There are many variations, layers, and +complexities to that simple question. The question “What is life?” simply +faded away. The same may eventually apply to feeling and +understanding. + +SELF-AWARE ROBOTS + +What steps must be taken before computers like Watson have self- +awareness? To answer this question, we have to refer back to our +definition of self-awareness: the ability to put one’s self inside a model of +the environment, and then run simulations of this model into the future +to achieve a goal. This first step requires a very high level of common +sense in order to anticipate a variety of events. Then the robot has to put +itself inside this model, which requires an understanding of the various +courses of action it may take." +"At Meiji University, scientists have taken the first steps to create a +robot with self-awareness. This is a tall order, but they think they can do +it by creating robots with a Theory of Mind. They started by building +two robots. The first was programmed to execute certain motions. The +second was programmed to observe the first robot, and then to copy it. +They were able to create a second robot that could systematically mimic +the behavior of the first just by watching it. This is the first time in +history that a robot has been built specifically to have some sense of self- +awareness. The second robot has a Theory of Mind; that is, it is capable +of watching another robot and then mimicking its motions. + +In 2012, the next step was taken by scientists at Yale University who" +"In 2012, the next step was taken by scientists at Yale University who + + created a robot that passed the mirror test. When animals are placed in +front of a mirror, most of them think the image in the mirror is that of +another animal. As we recall, only a few animals have passed the mirror +test, realizing that the mirror image was a reflection of themselves. The +scientists at Yale created a robot called Nico that resembles a gangly +skeleton made of twisted wires, with mechanical arms and two bulging +eyes sitting on top. When placed in front of a mirror, Nico not only +recognized itself but could also deduce the location of objects in a room + +by looking at their images in the mirror. This is similar to what we do +when we look into a rearview mirror and infer the location of objects +behind us." +"Nico’s programmer, Justin Hart, says, “To our knowledge, this is the +first robotic system to attempt to use a mirror in this way, representing a +significant step towards a cohesive architecture that allows robots to +learn about their bodies and appearance through self-observation, and +an important capability required in order to pass the mirror test.” + +Because the robots at Meiji University and Yale University represent +the state of the art in terms of building robots with self-awareness, it is +easy to see that scientists have a long ways to go before they can create +robots with humanlike self-awareness. + +Their work is just the first step, because our definition of self- +awareness demands that the robot use this information to create +simulations of the future. This is far beyond the capability of Nico or any +other robot." +"This raises the important question: How can a computer gain full self- +awareness? In science fiction, we often encounter a situation where the +Internet suddenly becomes self-aware, as in the movie The Terminator. +Since the Internet is connected to the entire infrastructure of modern +society (e.g., our sewer system, our electricity, our telecommunications, +our weapons), it would be easy for a self-aware Internet to seize control +of society. We would be left helpless in this situation. Scientists have +written that this may happen as an example of an “emergent +phenomenon” (i.e., when you amass a sufficiently large number of +computers together, there can be a sudden phase transition to a higher +stage, without any input from the outside). + +However, this says everything and it says nothing, because it leaves +out all the important steps in between. It’s like saying that a highway +can suddenly become self-aware if there are enough roads." +"But in this book we have given a definition of consciousness and self- +awareness, so it should be possible to list the steps by which the Internet + + can become self-aware. + +First, an intelligent Internet would have to continually make models of +its place in the world. In principle, this information can be programmed +into the Internet from the outside. This would involve describing the +outside world (i.e., Earth, its cities, and its computers), all of which can + +be found on the Internet itself. + +Second, it would have to place itself in the model. This information is +also easily obtained. It would involve giving all the specifications of the +Internet (the number of computers, nodes, transmission lines, etc.) and +its relationship to the outside world." +"But step three is by far the most difficult. It means continually running +simulations of this model into the future, consistent with a goal. This is +where we hit a brick wall. The Internet is not capable of running +simulations into the future, and it has no goals. Even in the scientific +world, simulations into the future are usually done in just a few +parameters (e.g., simulating the collision of two black holes). Running a +simulation of the model of the world containing the Internet is far +beyond the programming available today. It would have to incorporate +all the laws of common sense, all the laws of physics, chemistry, and +biology, as well as facts about human behavior and human society. + +In addition, this intelligent Internet would have to have a goal. Today +it is just a passive highway, without any direction or purpose. Of course, +one can in principle impose a goal on the Internet. But let us consider +the following problem: Can you create an Internet whose goal is self- +preservation?" +"This would be the simplest possible goal, but no one knows how to +program even this simple task. Such a program, for example, would have +to stop any attempt to shut down the Internet by pulling the plug. At +present, the Internet is totally incapable of recognizing a threat to its +existence, let alone plotting ways to prevent it. (For example, an Internet +capable of detecting threats to its existence would have to be able to +identify attempts to shut down its power, cut lines of communication, +destroy its servers, disable its fiber-optic and satellite connections, etc. +Furthermore, an Internet capable of defending itself against these attacks +would have to have countermeasures for each scenario and then run +these attempts into the future. No computer on Earth is capable of doing +even a fraction of such things.) + +In other words, one day it may be possible to create self-aware robots, +even a self-aware Internet, but that day is far into the future, perhaps at +the end of this century." +"But assume for the moment that the day has arrived, that self-aware +robots walk among us. If a self-aware robot has goals that are + +compatible with our own, then this type of artificial intelligence will not +pose a problem. But what happens if the goals are different? The fear is +that humans may be outwitted by self-aware robots and then may be +enslaved. Because of their superior ability to simulate the future, the +robots could plot the outcomes of many scenarios to find the best way to +overthrow humanity. + +One way this possibility may be controlled is to make sure that the +goals of these robots are benevolent. As we have seen, simulating the +future is not enough. These simulations must serve some final goal. If a +robot’s goal is merely to preserve itself, then it would react defensively +to any attempt to pull the plug, which could spell trouble for mankind. + +WILL ROBOTS TAKE OVER?" +"WILL ROBOTS TAKE OVER? + +In almost all science-fiction tales, the robots become dangerous because +of their desire to take over. The word “robot,” in fact, comes from the +Czech word for “worker,” first seen in the 1920 play R.U.R. (Rossum’s +Universal Robots) by Karel Capek, in which scientists create a new race of +mechanical beings that look identical to humans. Soon there are +thousands of these robots performing menial and dangerous tasks. +However, humans mistreat them badly, and one day they rebel and +destroy the human race. Although these robots have taken over Earth, +they have one defect: they cannot reproduce. But at the end of the play, +two robots fall in love. So perhaps a new branch of “humanity” emerges +once again." +"A more realistic scenario comes from the movie The Terminator, in +which the military has created a supercomputer network called Skynet +that controls the entire U.S. nuclear stockpile. One day, it wakes up and +becomes sentient. The military tries to shut down Skynet but then +realizes there is a flaw in its programming: it is designed to protect itself, +and the only way to do so is by eliminating the problem—humanity. It +starts a nuclear war, which reduces humanity to a ragtag bunch of +misfits and rebels fighting the juggernaut of the machines. + +It is certainly possible that robots could become a threat. The current +Predator drone can target its victims with deadly accuracy, but it is +controlled by someone with a joystick thousands of miles away." +"According to the New York Times, the orders to fire come directly from +the president of the United States. But in the future, a Predator might +have face recognition technology and permission to fire if it is 99 +percent confident of the identity of its target. Without human +intervention, it could automatically use this technology to fire at anyone +who fits the profile. + +Now assume that such a drone suffers a breakdown, such that its facial +recognition software malfunctions. Then it becomes a rogue robot, with +permission to kill anyone in sight. Worse, imagine a fleet of such robots +controlled by a central command. If a single transistor were to blow out +in this central computer and malfunction, then the entire fleet might go +on a killing spree." +"A more subtle problem is when robots perform perfectly well, without +any malfunctions, yet there is a tiny but fatal flaw in their programming +and goals. For a robot, self-preservation is one important goal. But so is +being helpful to humans. The real problem arises when these goals +contradict each other. + +In the movie 1 , Robot, the computer system decides that humans are +self-destructive, with their never-ending wars and atrocities, and that the +only way to protect the human race is to take over and create a +benevolent dictatorship of the machine. The contradiction here is not +between two goals, but within a single goal that is not realistic. These +murderous robots do not malfunction—they logically conclude that the +only way to preserve humanity is to take control of society." +"One solution to this problem is to create a hierarchy of goals. For +example, the desire to help humans must outrank self-preservation. This +theme was explored in the movie 2001 . The computer system HAL 9000 +was a sentient computer capable of conversing easily with humans. But +the orders given to HAL 9000 were self-contradictory and could not be +logically carried out. By attempting to execute an impossible goal, it fell +off the mesa; it went crazy, and the only solution to obeying +contradictory commands from imperfect humans was to eliminate the +humans. + +The best solution might be to create a new law of robotics, which +would state that robots cannot do harm to the human race, even if there +are contradictions within their previous directives. They must be +programmed to ignore lower-level contradictions within their orders and" +"always preserve the supreme law. But this might still be an imperfect +system at best. (For example, if the robots’ central goal is to protect +humanity to the exclusion of all other goals, then it all depends on how + + the robots define the word “protect.” Their mechanical definition of this +word may differ from ours.) + +Instead of reacting with terror, some scientists, such as Dr. Douglas +Hofstadter, a cognitive scientist at Indiana University, do not fear this +possibility. When I interviewed him, he told me that robots are our +children, so why shouldn’t we love them like our own? His attitude, he +told me, is that we love our children, even though we know that they +will take over." +"When I interviewed Dr. Hans Moravec, former director of the AI +Laboratory at Carnegie Mellon University, he agreed with Dr. Hofstadter. +In his book Robot, he writes, “Unleashed from the plodding pace of +biological evolution, the children of our minds will be free to grow to +confront immense and fundamental challenges in the larger universe. +... We humans will benefit for a time from their labors, but ... like +natural children, they will seek their own fortunes, while we, their aged +parents, silently fade away.” + +Others, on the contrary, think that this is a horrible solution. Perhaps +the problem can be solved if we make changes in our goals and priorities +now, before it is too late. Since these robots are our children, we should +“teach” them to be benevolent. + +FRIENDLY AI" +"FRIENDLY AI + +Robots are mechanical creatures that we make in the laboratory, so +whether we have killer robots or friendly robots depends on the +direction of AI research. Much of the funding comes from the military, +which is specifically mandated to win wars, so killer robots are a definite +possibility. + +However, since 30 percent of all commercial robots are manufactured +in Japan, there is another possibility: robots will be designed to become +helpful playmates and workers from the very beginning. This goal is +feasible if the consumer sector dominates robotics research. The +philosophy of “friendly AI” is that inventors should create robots that, + +from the very first steps, are programmed to be beneficial to humans." +"from the very first steps, are programmed to be beneficial to humans. + +Culturally, the Japanese approach to robots is different from the +West’s. While kids in the West might feel terror watching rampaging +Terminatortype robots, kids in Japan are steeped in the Shinto religion, +which believes spirits live in all things, even mechanical robots. Instead +of being uncomfortable at the sight of robots, Japanese children squeal" +"with delight upon encountering them. It’s no wonder, therefore, that +these robots in Japan are proliferating in the marketplace and in homes. +They greet you at department stores and educate you on TV. There is +even a serious play in Japan featuring a robot. (Japan has another +reason for embracing robots. These are the future robot nurses for an +aging country. Twenty-one percent of the population is over sixty-five, +and Japan is aging faster than any other nation. In some sense, Japan is +a train wreck in slow motion. Three demographic factors are at work. +First, Japanese women have the longest life expectancy of any ethnic +group in the world. Second, Japan has one of the world’s lowest +birthrates. Third, it has a strict immigration policy, with over 99 percent +of the population being pure Japanese. Without young immigrants to +take care of the elderly, Japan may rely on robot nurses. This problem is +not restricted to Japan; Europe is next. Italy, Germany, Switzerland, and" +"not restricted to Japan; Europe is next. Italy, Germany, Switzerland, and +other European nations face similar demographic pressures. The +populations of Japan and Europe could experience severe shrinkage by +mid-century. The United States is not far behind. The birthrate of native- +born U.S. citizens has also fallen dramatically in the last few decades, +but immigration will keep the United States expanding into this century. +In other words, it could be a trilliondollar gamble to see if robots can +save us from these three demographic nightmares.)" +"Japan leads the world in creating robots that can enter our personal +lives. The Japanese have built robots that can cook (one can make a +bowl of noodles in a minute and forty seconds). When you go to a +restaurant, you can place your order on a tablet computer and the robot +cook springs into action. It consists of two large, mechanical arms, which +grab the bowls, spoons, and knives and prepare the food for you. Some +robotic cooks even resemble human ones. + +There are also musical robots for entertainment. One such robot +actually has accordion-like “lungs” by which it can generate music by +pumping air through an instrument. There are also robot maids. If you" +"carefully prepare your laundry, it can fold it in front of you. There is +even a robot that can talk because it has artificial lungs, lips, tongue, +and nasal cavity. The Sony Corporation, for example, built the AIBO +robot, which resembles a dog and can register a number of emotions if +you pet it. Some futurists predict that the robotics industry may one day +become as large as the automobile industry is today. + +The point here is that robots are not necessarily programmed to +destroy and dominate. The future of AI is up to us. + +But some critics of friendly AI claim that robots may take over not +because they are aggressive, but because we are sloppy in creating them. +In other words, if the robots take over, it will be because we + + programmed them to have conflicting goals. + +“I AM A MACHINE”" +"programmed them to have conflicting goals. + +“I AM A MACHINE” + +When I interviewed Dr. Rodney Brooks, former director of the MIT +Artificial Intelligence Lab and cofounder of iRobot, I asked him if he +thought machines would one day take over. He told me that we just +have to accept that we are machines ourselves. This means that one day, +we will be able to build machines that are just as alive as we are. But, he +cautioned, we will have to give up the concept of our “specialness.” + +This evolution in human perspective started with Nicolaus Copernicus +when he realized that the Earth was not the center of the universe, but +rather goes around the sun. It continued with Darwin, who showed that +we were similar to the animals in our evolution. And it will continue +into the future, he told me, when we realize that we are machines, +except that we are made of wetware and not hardware." +"It’s going to represent a major change in our world outlook to accept +that we, too, are machines, he believes. He writes, “We don’t like to give +up our specialness, so you know, having the idea that robots could really +have emotions, or that robots could be living creatures—I think is going +to be hard for us to accept. But we’re going to come to accept it over the +next fifty years.” + +But on the question of whether the robots will eventually take over, he +says that this will probably not happen, for a variety of reasons. First, no +one is going to accidentally build a robot that wants to rule the world. + +He says that creating a robot that can suddenly take over is like someone +accidentally building a 747 jetliner. Plus, there will be plenty of time to +stop this from happening. Before someone builds a “super-bad robot,” +someone has to build a “mildly bad robot,” and before that a “not-so-bad +robot.”" +"His philosophy is summed up when he says, “The robots are coming, +but we don’t have too much to worry about. It’s going to be a lot of fun.” +To him, the robot revolution is a certainty, and he foresees the day when +robots will surpass human intelligence. The only question is when. But +there is nothing to fear, since we will have created them. We have the +choice to create them to help, and not hinder, us. + +MERGE WITH THEM? + + If you ask Dr. Brooks how we can coexist with these super-smart robots, +his reply is straightforward: we will merge with them. With advances in +robotics and neuroprosthetics, it becomes possible to incorporate AI into +our own bodies. + +Dr. Brooks notes that the process, in some sense, has already begun. +Today, about twenty thousand people have had cochlear implants, +which have given them the gift of hearing. Sounds are picked up by a +tiny receiver, which converts sound waves to electrical signals, which +are then sent directly to the auditory nerves of the ear." +"Similarly, at the University of Southern California and elsewhere, it is +possible to take a patient who is blind and implant an artificial retina. +One method places a mini video camera in eyeglasses, which converts an +image into digital signals. These are sent wirelessly to a chip placed in +the person’s retina. The chip activates the retina’s nerves, which then +send messages down the optic nerve to the occipital lobe of the brain. In +this way, a person who is totally blind can see a rough image of familiar +objects. Another design has a light-sensitive chip placed on the retina +itself, which then sends signals directly to the optic nerve. This design +does not need an external camera. + +This also means that we can go even further and enhance ordinary +senses and abilities. With cochlear implants, it will be possible to hear +high frequencies that we have never heard before. Already with infrared" +"glasses, one can see the specific type of light that emanates from hot +objects in the dark and that is normally invisible to the human eye. With +artificial retinas, it may be possible to enhance our ability to see +ultraviolet or infrared light. (Bees, for example, can see UV light because +they have to lock onto the sun in order to navigate to a flower bed.) + +Some scientists even dream of the day when exoskeletons will have +superpowers like those found in comic books, with super strength, super +senses, and super abilities. We’d become a cyborg like Iron Man, a +normal human with superhuman abilities and powers. This means that +we might not have to worry about super-intelligent robots taking over. +We’d simply merge with them." +"This, of course, is for the distant future. But some scientists, frustrated +that robots are not leaving the factory and entering our lives, point out +that Mother Nature has already created the human mind, so why not +copy it? Their strategy is to take the brain apart, neuron by neuron, and +then reassemble it. + +But reverse engineering entails more than just creating a vast + + blueprint to create a living brain. If the brain can be duplicated down to +the last neuron, perhaps we can upload our consciousness into a +computer. We’d have the ability to leave our mortal bodies behind. This +is beyond mind over matter. This is mind without matter. + +I’m as fond of my body as anyone, but if I can be 200 with a +body of silicon, I’ll take it. + +—DANIEL HILL, COFOUNDER OF THINKING MACHINES CORP. + +11 REVERSE ENGINEERING THE BRAIN" +"—DANIEL HILL, COFOUNDER OF THINKING MACHINES CORP. + +11 REVERSE ENGINEERING THE BRAIN + +In January 2013, two bombshells were dropped that could alter the +medical and scientific landscape forever. Overnight, reverse engineering +the brain, once considered to be too complex to solve, suddenly became +a focal point of scientific rivalry and pride between the greatest +economic powers on Earth." +"First, in his State of the Union address, President Barack Obama +stunned the scientific community by announcing that federal research +funds, perhaps to the tune of $3 billion, might be allocated to the Brain +Research Through Advancing Innovative Neurotechnologies (or BRAIN) +Initiative. Like the Human Genome Project, which opened the floodgates +for genetic research, BRAIN will pry open the secrets of the brain at the +neural level by mapping its electrical pathways. Once the brain is +mapped, a host of intractable diseases like Alzheimer’s, Parkinson’s, +schizophrenia, dementia, and bipolar disorder might be understood and +possibly cured. To jump-start BRAIN, $100 million might be allocated in +2014 toward the project." +"Almost simultaneously, the European Commission announced that the +Human Brain Project would be awarded 1.19 billion euros (about $1.6 +billion) to create a computer simulation of the human brain. Using the +power of the biggest supercomputers on the planet, the Human Brain +Project will create a copy of the human brain made of transistors and +steel. + +Proponents of both projects stressed the enormous benefits of these +endeavors. President Obama was quick to point out that not only would +BRAIN alleviate the suffering of millions of people, it will also generate +new revenue streams. For every dollar spent on the Human Genome +Project, he claimed, about $140 of economic activity was generated. +Entire industries, in fact, sprouted with the completion of the Human +Genome Project. For the taxpayer, BRAIN, like the Human Genome + + Project, will be a win-win situation." +"Project, will be a win-win situation. + +Although Obama’s speech did not give details, scientists quickly filled +in many of the gaps. Neurologists pointed out that, on one hand, it is +now possible to use delicate instruments to monitor the electrical +activity of single neurons. On the other hand, using MRI machines, it is +possible to monitor the global behavior of the entire brain. What is +missing, they pointed out, is the middle ground, where most of the +interesting brain activity takes place. It is in this middle ground, +involving the pathways of thousands to millions of neurons, that there +are huge gaps in our understanding of mental disease and behavior." +"To tackle this enormous problem, scientists laid out a tentative fifteen- +year program. In the first five years, neurologists hope to monitor the +electrical activity of tens of thousands of neurons. The short-term goals +might include reconstructing the electrical activity of important parts of +animal brains, such as the medulla of the Drosophila fruit fly or the +ganglion cells in a mouse retina (which has fifty thousand neurons). + +Within ten years, that number should increase to hundreds of +thousands of neurons. This could include imaging the entire Drosophila +brain (135,000 neurons) or even the cortex of the Etruscan shrew, the +smallest known mammal, with a million neurons. + +Finally, within fifteen years, it should be possible to monitor millions +of neurons, comparable to the zebrafish brain or the entire neocortex of +a mouse. This could pave the way toward imaging parts of the brains of +primates." +"Meanwhile, in Europe, the Human Brain Project would tackle the +problem from a different point of view. Over a ten-year period, it will +use supercomputers to simulate the basic functioning of the brains of +different animals, starting with mice and working up to humans. Instead +of dealing with individual neurons, the Human Brain Project will use +transistors to mimic their behavior, so that there will be computer +modules that can act like the neocortex, the thalamus, and other parts of +the brain. + +In the end, the rivalry between these two gigantic projects could +create a windfall by generating new discoveries for treating incurable +diseases and spawning new industries. But there is also another, unstated +goal. If one can eventually simulate a human brain, does it mean that +the brain can become immortal? Does it mean that consciousness can +now exist outside the body? Some of the thorniest theological and + + metaphysical questions are raised by these ambitious projects. + +BUILDING A BRAIN" +"metaphysical questions are raised by these ambitious projects. + +BUILDING A BRAIN + +Like many other children, I used to love taking apart clocks, +disassembling them, screw for screw, and then trying to see how the +whole thing fit together. I would trace each part mentally, seeing how +one gear connected to the next one, until the whole thing fit together. I +realized the mainspring turned the main gear, which then fed a sequence +of smaller gears, which eventually turned the hands of the clock. + +Today, on a much larger scale, computer scientists and neurologists +are trying to take apart an infinitely more complex object, the most +sophisticated object we know about in the universe: the human brain. +Moreover, they wish to reassemble it, neuron by neuron." +"Because of rapid advances in automation, robotics, nanotechnology, +and neuroscience, reverse engineering the human brain is no longer idle +speculation for polite after-dinner banter. In the United States and +Europe, billions of dollars will soon be flowing into projects once +considered preposterous. Today a small band of visionary scientists are +dedicating their professional lives to a project that they may not live to +see completed. Tomorrow their ranks could swell into an entire army, +generously funded by the United States and the nations of Europe. + +If successful, these scientists could alter the course of human history. +Not only might they find new cures and therapies for mental illnesses, +they might also unlock the secret of consciousness and perhaps upload it +into a computer." +"It is a daunting task. The human brain consists of over one hundred +billion neurons, approximately as many stars as there are in the Milky +Way galaxy. Each neuron, in turn, is connected to perhaps ten thousand +other neurons, so altogether there are a total of ten million billion +possible connections (and that does not begin to compute the number of +pathways there are among this thicket of neurons). The number of +“thoughts” that a human brain can conceive of is therefore truly +astronomical and beyond human ken. + +Yet that has not stopped a small bunch of fiercely dedicated scientists +from attempting to reconstruct the brain from scratch. There is an old + +Chinese proverb, “A journey of a thousand miles begins with the first +step.” That first step was actually taken when scientists decoded, neuron +for neuron, the nervous system of a nematode worm. This tiny creature," +"called C. elegans, has 302 neurons and 7,000 synapses, all of which have +been precisely recorded. A complete blueprint of its nervous system can +be found on the Internet. (Even today, it is the only living organism to +have its entire neural structure decoded in this way.) + +At first, it was thought that the complete reverse engineering of this +simple organism would open the door to the human brain. Ironically, the +opposite has happened. Although the nematode’s neurons were finite in +number, the network is still so complex and sophisticated that it has +taken years to understand even simple facts about worm behavior, such +as which pathways are responsible for which behaviors. If even the +lowly nematode worm could elude our scientific understanding, +scientists were forced to appreciate how complex a human brain must +be. + +THREE APPROACHES TO THE BRAIN" +"THREE APPROACHES TO THE BRAIN + +Because the brain is so complex, there are at least three distinct ways in +which it can be taken apart, neuron by neuron. The first is to simulate +the brain electronically with supercomputers, which is the approach +being taken by the Europeans. The second is to map out the neural +pathways of living brains, as in BRAIN. (This task, in turn, can be further +subdivided, depending on how these neurons are analyzed—either +anatomically, neuron by neuron, or by function and activity.) And third, +one can decipher the genes that control the development of the brain, +which is an approach pioneered by billionaire Paul Allen of Microsoft." +"The first approach, simulating the brain using transistors and +computers, is forging ahead by reverse engineering the brains of animals +in a certain sequence: first a mouse, then a rat, rabbit, and a cat. The +Europeans are following the rough trail of evolution, starting with +simple brains and working upward. To a computer scientist, the solution +is raw computing power—the more, the better. And this means using +some of the largest computers on Earth to decipher the brains of mice +and men." +"Their first target is the brain of a mouse, which is one-thousandth the +size of a human brain, containing about one hundred million neurons. +The thinking process behind a mouse brain is being analyzed by the IBM +Blue Gene computer, located at the Lawrence Livermore National +Laboratory in California, where some of the biggest computers in the +world are located; they’re used to design hydrogen warheads for the +Pentagon. This colossal collection of transistors, chips, and wires +contains 147,456 processors with a staggering 150,000 gigabytes of +memory. (A typical PC may have one processor and a few gigabytes of + + memory.) + +Progress has been slow but steady. Instead of modeling the entire +brain, scientists try to duplicate just the connections between the cortex +and the thalamus, where much of brain activity is concentrated. (This +means that the sensory connections to the outside world are missing in +this simulation.)" +"In 2006, Dr. Dharmendra Modha of IBM partially simulated the mouse +brain in this way with 512 processors. In 2007, his group simulated the +rat brain with 2,048 processors. In 2009, the cat brain, with 1.6 billion +neurons and nine trillion connections, was simulated with 24,576 +processors. + +Today, using the full power of the Blue Gene computer, IBM scientists +have simulated 4.5 percent of the human brain’s neurons and synapses. +To begin a partial simulation of the human brain, one would need +880,000 processors, which might be possible around 2020. + +I had a chance to film the Blue Gene computer. To get to the +laboratory, I had to go through layers and layers of security, since it is +the nation’s premier weapons laboratory, but once you have cleared all +the checkpoints, you enter a huge, air-conditioned room housing Blue +Gene." +"The computer is truly a magnificent piece of hardware. It consists of +racks and racks of large black cabinets full of switches and blinking +lights, each about eight feet tall and roughly fifteen feet long. As I +walked among the cabinets that make up Blue Gene, I wondered what +kinds of operations it was performing. Most likely, it was modeling the +interior of a proton, calculating the decay of plutonium triggers, +simulating the collision of two black holes, and thinking of a mouse, all +at once. + +Then I was told that even this supercomputer is giving way to the next +generation, the Blue Gene/Q Sequoia, which will take computing to a +new level. In June 2012, it set the world’s record for the fastest +supercomputer. At peak speed, it can perform operations at 20.1 PFLOPS +(or 20.1 trillion floating point operations per second). It covers an area +of three thousand square feet, and gobbles up electrical energy at the +rate of 7.9 megawatts, enough power to light up a small city." +"But with all this massive computational firepower concentrated in one +computer, is it enough to rival the human brain? + +Unfortunately, no. + + These computer simulations try only to duplicate the interactions +between the cortex and the thalamus. Huge chunks of the brain are +therefore missing. Dr. Modha understands the enormity of his project. +His ambitious research has allowed him to estimate what it would take +to create a working model of the entire human brain, and not just a +portion or a pale version of it, complete with all parts of the neocortex +and connections to the senses. He envisions using not just a single Blue +Gene computer but thousands of them, which would fill up not just a +room but an entire city block. The energy consumption would be so +great that you would need a thousand-megawatt nuclear power plant to +generate all the electricity. And then, to cool off this monstrous +computer so it wouldn’t melt, you would need to divert a river and send +it through the computer circuits." +"It is remarkable that a gigantic, city-size computer is required to +simulate a piece of human tissue that weighs three pounds, fits inside +your skull, raises your body temperature by only a few degrees, uses +twenty watts of power, and needs only a few hamburgers to keep it +going. + +BUILDING A BRAIN + +But perhaps the most ambitious scientist who has joined this campaign is +Dr. Henry Markram of the Ecole Polytechnique Federate de Lausanne, in +Switzerland. He is the driving force behind the Human Brain Project, +which has received over a billion dollars of funding from the European +Commission. He has spent the last seventeen years of his life trying to + +decode the brain’s neural wiring. He, too, is using the Blue Gene +computer to reverse engineer the brain. At present, his Human Brain +Project is running up a bill of $140 million from the European Union, +and that represents only a fraction of the computer firepower he will +need in the coming decade." +"Dr. Markram believes that this is no longer a science project but an +engineering endeavor, requiring vast sums of money. He says, “To build +this—the supercomputers, the software, the research—we need around +one billion dollars. This is not expensive when one considers that the +global burden of brain disease will exceed twenty percent of the world +gross domestic project very soon.” To him, a billion dollars is nothing, +just a pittance compared to the hundreds of billions in bills stemming +from Alzheimer’s, Parkinson’s, and other related diseases when the baby +boomers retire. + +So to Dr. Markram, the solution is one of scale. Throw enough money + + at the project, and the human brain will emerge. Now that he has won +the coveted billion-dollar prize from the European Commission, his +dream may become a reality." +"He has a ready answer when asked what the average taxpayer will get +from this billion-dollar investment. There are three reasons, he says, for +embarking on this lonely but expensive quest. First, “It’s essential for us +to understand the human brain if we want to get along in society, and I +think that it is a key step in evolution. The second reason is, we cannot +keep doing animal experimentation forever.... It’s like a Noah’s Ark. It’s +like an archive. And the third reason is that there are two billion people +on this planet that are affected by mental disorder....” + +To him, it is a scandal that so little is known about mental diseases, +which cause so much suffering to millions of people. He says, “There’s +not a single neurological disease today in which anybody knows what is +malfunctioning in this circuit—which pathway, which synapse, which +neuron, which receptor. This is shocking.”" +"At first, it may sound impossible to complete this project, with so +many neurons and so many connections. It seems like a fool’s errand. +But these scientists think they have an ace in the hole. + +The human genome consists of roughly twenty-three thousand genes, +yet it can somehow create the brain, which consists of one hundred +billion neurons. It seems to be a mathematical impossibility to create the + +human brain from our genes, yet it happens every time an embryo is +conceived. How can so much information be crammed into something so +small? + +The answer, Dr. Markram believes, is that nature uses shortcuts. The +key to his approach is that certain modules of neurons are repeated over +and over again once Mother Nature finds a good template. If you look at +microscopic slices of the brain, at first you see nothing but a random +tangle of neurons. But upon closer examination, patterns of modules that +are repeated over and over appear." +"(Modules, in fact, are one reason why it is possible to assemble large +skyscrapers so rapidly. Once a single module is designed, it is possible to +repeat it endlessly on the assembly line. Then you can rapidly stack +them on top of one another to create the skyscraper. Once the +paperwork is all signed, an apartment building can be assembled using +modules in a few months.) + +The key to Dr. Markram’s Blue Brain project is the “neocortical +column,” a module that is repeated over and over in the brain. In + + humans, each column is about two millimeters tall, with a diameter of +half a millimeter, and contains sixty thousand neurons. (As a point of +comparison, rat neural modules contain only ten thousand neurons +each.) It took ten years, from 1995 to 2005, for Dr. Markram to map the +neurons in such a column and to figure out how it worked. Once that +was deciphered, he then went to IBM to create massive iterations of +these columns." +"He is the eternal optimist. In 2009, at a TED conference, he claimed he +could finish the project in ten years. (Most likely, this will be for a +stripped-down version of the human brain without any attachment to +the other lobes or to the senses.) But he has claimed, “If we build it +correctly, it should speak and have an intelligence and behave very +much as a human does.” + +Dr. Markram is a skilled defender of his work. He has an answer for +everything. When critics say that he is treading on forbidden territory, +he counters, “As scientists, we need to be not afraid of the truth. We +need to understand our brain. It’s natural that people would think that +the brain is sacred, that we shouldn’t tamper with it because it may be +where the secrets of the soul are. But I think, quite honestly, that if the +planet understood how the brain functions, we would resolve conflicts" +"everywhere. Because people would understand how trivial and how +deterministic and how controlled conflicts and reactions and +misunderstandings are.” + +When faced with the final criticism that he is “playing God,” he says, +“I think we’re far from playing God. God created the whole universe. +We’re just trying to build a little model.” + +IS IT REALLY A BRAIN? + +Although these scientists claim that their computer simulation of the +brain will begin to reach the capability of the human brain by around +2020, the main question is, How realistic is this simulation? Can the cat +simulation, for example, catch a mouse? Or play with a ball of yarn?" +"The answer is no. These computer simulations try to match the sheer +power of the neurons firing in the cat brain, but they cannot duplicate +the way in which the regions of the brain are hooked together. The IBM +simulation is only for the thalamocortical system (i.e., the channel that +connects the thalamus to the cortex). The system does not have a +physical body, and hence all the complex interactions between the brain +and the environment are missing. The brain has no parietal lobe, so it + + has no sensory or motor connections with the outside world. And even +within the thalamocortical system, the basic wiring does not respect the +thinking process of a cat. There are no feedback loops and memory +circuits for stalking prey or finding a mate. The computerized cat brain +is a blank slate, devoid of any memories or instinctual drives. In other +words, it cannot catch a mouse." +"So even if it is possible to simulate a human brain by around 2020, +you will not be able to have a simple conversation with it. Without a +parietal lobe, it would be like a blank slate without sensations, devoid of +any knowledge of itself, people, and the world around it. Without a +temporal lobe, it would not be able to talk. Without a limbic system, it +would not have any emotions. In fact, it would have less brain power +than a newborn infant. + +The challenge of hooking up the brain to the world of sensations, +emotions, language, and culture is just beginning. + +THE SLICE-AND-DICE APPROACH + +The next approach, favored by the Obama administration, is to map the +neurons of the brain directly. Instead of using transistors, this approach +analyzes the actual neural pathways of the brain. There are several +components to it." +"One way to proceed is to physically identify each and every neuron +and synapse of the brain. (The neurons are usually destroyed by this +process.) This is called the anatomical approach. Another path is to +decipher the ways in which electrical signals flow across neurons when +the brain is performing certain functions. (The latter approach, which +stresses identifying the pathways of the living brain, is the one that +seems to be favored by the Obama administration.)" +"The anatomical approach is to take apart the cells of an animal brain, +neuron by neuron, using the “slice-and-dice” method. In this way, the +full complexity of the environment, the body, and memories are already +encoded in the model. Instead of approximating a human brain by +assembling a huge number of transistors, these scientists want to identify +each neuron of the brain. After that, perhaps each neuron can be +simulated by a collection of transistors so that you’d have an exact +replica of the human brain, complete with memory, personality, and +connection to the senses. Once someone’s brain is fully reversed +engineered in this way, you should be able to have an informative +conversation with that person, complete with memories and a +personality." +"No new physics is required to finish the project. Using a device similar +to a meat sheer in a delicatessen, Dr. Gerry Rubin of the Howard Hughes +Medical Institute has been slicing the brain of a fruit fly. This is not an +easy task, since the fruit fly brain is only three hundred micrometers +across, a tiny speck compared to the human brain. The fruit fly brain +contains about 150,000 neurons. Each slice, which is only fifty-billionths +of a meter across, is meticulously photographed with an electron +microscope, and the images are fed into a computer. Then a computer +program tries to reconstruct the wiring, neuron by neuron. At the +present rate, Dr. Rubin will be able to identify every neuron in the fruit +fly brain in twenty years. + +The snail-like pace is due, in part, to current photographic technology," +"The snail-like pace is due, in part, to current photographic technology, + +since a standard scanning microscope operates at about ten million +pixels per second. (That is about a third of the resolution achieved by a +standard TV screen per second.) The goal is to have an imaging machine +that can process ten billion pixels per second, which would be a world +record. + +The problem of how to store the data pouring in from the microscope +is also staggering. Once his project gets up to speed, Rubin expects to +scan about a million gigabytes of data per day for just a single fruit fly, +so he envisions filling up huge warehouses full of hard drives. On top of +that, since every fruit fly brain is slightly different, he has to scan +hundreds of fruit fly brains in order to get an accurate approximation of +one." +"Based on working with the fruit fly brain, how long will it take to +eventually slice up the human brain? “In a hundred years, I’d like to +know how human consciousness works. The ten- or twenty-year goal is +to understand the fruit fly brain,” he says. + +This method can be speeded up with several technical advances. One +possibility is to use an automated device, so that the tedious process of +slicing the brain and analyzing each slide is done by machine. This could +rapidly reduce the time for the project. Automation, for example, vastly +reduced the cost of the Human Genome Project (although it was +budgeted at $3 billion, it was accomplished ahead of time and under +budget, which is unheard of in Washington). Another method is to use a +large variety of dyes that will tag different neurons and pathways, +making them easier to see. An alternative approach would be to create +an automated super microscope that can scan neurons one by one with +unparalleled detail." +"Given that a complete mapping of the brain and all its senses will take +up to a hundred years, these scientists feel somewhat like the medieval + + architects who designed the cathedrals of Europe, knowing that their +grandchildren would finally complete the project. + +In addition to constructing an anatomical map of the brain, neuron by +neuron, there is a parallel effort called the “Human Connectome +Project,” which uses brain scans to reconstruct the pathways connecting +various regions of the brain. + +THE HUMAN CONNECTOME PROJECT" +"THE HUMAN CONNECTOME PROJECT + +In 2010, the National Institutes of Health announced that it was +allocating $30 million, spread out over five years, to a consortium of +universities (including Washington University in St. Louis and the +University of Minnesota), and a $8.5 million grant over three years to a +consortium led by Harvard University, Massachusetts General Hospital, +and UCLA. With this level of short-term funding, of course, researchers +cannot fully sequence the entire brain, but the funding was meant to +jump-start the effort." +"Most likely, this effort will be folded into the BRAIN project, which +will vastly accelerate this work. The goal is to produce a neuronal map +of the human brain’s pathways that will elucidate brain disorders such as +autism and schizophrenia. One of the leaders of the Connectome Project, +Dr. Sebastian Seung, says, “Researchers have conjectured that the +neurons themselves are healthy, but maybe they are just wired together +in an abnormal way. But we’ve never had the technology to test that +hypothesis until now.” If these diseases are actually caused by the +miswiring of the brain, then the Human Connectome Project may give us +an invaluable clue as to how to treat these conditions." +"When considering the ultimate goal of imaging the entire human +brain, sometimes Dr. Seung despairs of ever finishing this project. He +says, “In the seventeenth century, the mathematician and philosopher +Blaise Pascal wrote of his dread of the infinite, his feeling of +insignificance at contemplating the vast reaches of outer space. And as a +scientist, I’m not supposed to talk about my feelings.... I feel curiosity, +and I feel wonder, but at times I have also felt despair.” But he and +others like him persist, even if their project will take multiple +generations to finish. They have reason to hope, since one day +automated microscopes will tirelessly take the photographs and +artificially intelligent machines will analyze them twenty-four hours a +day. But right now, just imaging the human brain with ordinary electron +microscopes would consume about one zettabyte of data, which is +equivalent to all the data compiled in the world today on the web." +"Dr. Seung even invites the public to participate in this great project by + + visiting a website called EyeWire. There, the average “citizen scientist” +can view a mass of neural pathways and is asked to color them in + +(staying within their boundaries). It’s like a virtual coloring book, except +images are of the actual neurons in the retina of an eye, taken by an +electron microscope. + +THE ALLEN BRAIN ATLAS + +Finally, there is a third way to map the brain. Instead of analyzing the +brain by using computer simulations or by identifying all the neural +pathways, yet another approach was taken with a generous grant of +$100 million from Microsoft billionaire Paul Allen. The goal was to +construct a map or atlas of the mouse brain, with the emphasis on +identifying the genes responsible for creating the brain." +"It is hoped that this understanding of how genes are expressed in the +brain will help in understanding autism, Parkinson’s, Alzheimer’s, and +other disabilities. Since a large number of mouse genes are found in +humans, it’s possible that findings here will give us insight into the +human brain. + +With this sudden infusion of funds, the project was completed in 2006, +and its results are freely available on the web. A follow-up project, the +Allen Human Brain Atlas, was announced soon afterward, with the hope +of creating an anatomically and genetically complete 3-D map of the +human brain. In 2011, the Allen Institute announced that it had mapped +the biochemistry of two human brains, finding one thousand anatomical +sites with one hundred million data points detailing how genes are +expressed in the underlying biochemistry. The study confirmed that 82 +percent of our genes are expressed in the brain." +"“Until now, a definitive map of the human brain, at this level of detail, +simply hasn’t existed,” says Dr. Allen Jones of the Allen Institute. “The +Allen Human Brain Atlas provides never-before-seen views into our most +complex and most important organ,” he adds. + +OBJECTIONS TO REVERSE ENGINEERING + +Scientists who have dedicated their lives to reverse engineering the brain +realize that decades of hard work lie ahead of them. But they are also +convinced of the practical implications of their work. They feel that even + + partial results will help decode the mystery of mental diseases that have +afflicted humans throughout our history." +"The cynics, however, may claim that, after this arduous task is +finished, we will have a mountain of data with no understanding of how +it all fits together. For example, imagine a Neanderthal who one day +comes across the complete blueprint for an IBM Blue Gene computer. All +the details are there in the blueprint, down to the very last transistor. +The blueprint is huge, taking up thousands of square feet of paper. The +Neanderthal may be dimly aware that this blueprint is the secret of a +super-powerful machine, but the sheer mass of technical data means +nothing to him. + +Similarly, the fear is that, after spending billions deciphering the +location of every neuron of the brain, we won’t be able to understand +what it all means. It may take many more decades of hard work to see +how the whole thing functions." +"For example, the Human Genome Project was a smashing success in +sequencing all the genes that make up the human genome, but it was a +huge disappointment for those who expected immediate cures for +genetic diseases. The Human Genome Project was like a gigantic +dictionary, with twenty-three thousand entries but no definitions. Page +after page of this dictionary is blank, yet the spelling of each gene is +perfect. The project was a breakthrough, but at the same time it’s just +the first step in a long journey to figure out what these genes do and +how they interact. + +Similarly, just having a complete map of every single neural +connection in the brain does not guarantee that we will know what these +neurons are doing and how they react. Reverse engineering is the easy +part; after that, the hard part begins—making sense of all this data. + +THE FUTURE" +"THE FUTURE + +But assume for now that the moment has finally arrived. With much +fanfare, scientists solemnly announce that they have successfully reverse +engineered the entire human brain. + +Then what? + +One immediate application is to find the origins of certain mental + + diseases. It’s thought that many mental diseases are not caused by the +massive destruction of neurons, but by a simple misconnection. Think of +genetic diseases that are caused by a single mutation, like Huntington’s +disease, Tay-Sachs, or cystic fibrosis. Out of three billion base pairs, a +single misspelling (or repetition) can cause uncontrollable flailing of +your limbs and convulsions, as in Huntington’s disease. Even if the +genome is 99.9999999 percent accurate, a tiny flaw might invalidate the +entire sequence. That is why gene therapy has targeted these single +mutations as possible genetic diseases that can be fixed." +"Likewise, once the brain is reverse engineered, it might be possible to +run simulations of the brain, deliberately disrupting a few connections to +see if you can induce certain illnesses. Only a handful of neurons may be +responsible for major disruptions of our cognition. Locating this tiny +collection of misfiring neurons may be one of the jobs of the reverse- +engineered brain." +"One example might be Capgras delusion, in which you see someone +you recognize as your mother, but you believe that person to be an +impostor. According to Dr. V. S. Ramachandran, this rare disease might +be due to a misconnection between two parts of the brain. The fusiform +gyrus in the temporal lobe is responsible for recognizing the face of your +mother, but the amygdala is responsible for your emotional response in +seeing your mother. When the connection between these two centers is +disrupted, an individual can recognize his mother’s face perfectly well, +but, since there is no emotional response, he is also convinced that she is +an impostor." +"Another use for the reverse-engineered brain is to pinpoint precisely +which cluster of neurons is misfiring. Deep brain stimulation, as we’ve +seen, involves using tiny probes to dampen the activity of a tiny portion +of the brain, such as Broadmann’s area 25, in the case of certain severe +forms of depression. Using the reverse-engineered map, it might be +possible to find precisely where the neurons are misfiring, which may +involve only a handful of neurons. + +A reversed-engineered brain would also be of great help to AI. Vision +and face recognition are done effortlessly by the brain, but they still +elude our most advanced computers. For example, computers can +recognize with 95 percent or greater accuracy human faces that look +straight ahead and are part of a small data bank, but if you show the" +"computer the same face from different angles or a face that’s not in the +database, the computer will most likely fail. Within .1 seconds, we can +recognize familiar faces from different angles; it’s so easy for our brains +that we are not even aware we are doing it. Reverse engineering the +brain may reveal the mystery of how this is done. + + More complicated would be diseases that involve multiple failures of +the brain, such as schizophrenia. This disorder involves several genes, +plus interactions with the environment, which in turn cause unusual +activity in several areas of the brain. But even there, a reverse- +engineered brain would be able to tell precisely how certain symptoms +(such as hallucinations) are formed, and this might pave the way for a +possible cure." +"A reverse-engineered brain would also solve such basic but unresolved +questions as how long-term memories are stored. It is known that certain +parts of the brain, such as the hippocampus and amygdala, store +memories, but how the memory is dispersed through various cortices +and then reassembled to create a memory is still unclear. + +Once the reverse-engineered brain is fully functional, then it will be +time to turn on all its circuits to see if it can respond like a human (i.e., +to see if it can pass the Turing test). Since long-term memory is already +encoded in the neurons of the reverse-engineered brain, it should be +obvious very quickly whether the brain can respond in a way +indistinguishable from a human. + +Finally, there is one impact of reverse engineering the brain that is +rarely discussed but is on many people’s minds: immortality. If +consciousness can be transferred into a computer, does that mean we +don’t have to die?" +"Speculation is never a waste of time. It clears away the +deadwood in the thickets of deduction. + +—ELIZABETH PETERS + +We are a scientific civilization.... That means a civilization in +which knowledge and its integrity are crucial. Science is only a +Latin word for knowledge.... Knowledge is our destiny. + +—JACOB BRONOWSKI + +12 THE FUTURE MIND BEYOND MATTER + +Can consciousness exist by itself, free from the constraints of the +physical body? Can we leave our mortal body and, like spirits, wander +around this playground called the universe? This was explored on Star" +"Trek, when Captain Kirk of the starship Enterprise encounters a +superhuman race, almost a million years more advanced than the +Federation of Planets. They are so advanced that they have long since +abandoned their frail, mortal bodies, and now inhabit pulsating globes of +pure energy. It has been millennia since they could feel intoxicating +sensations, such as breathing fresh air, touching another’s hand, or +feeling physical love. Their leader, Sargon, welcomes the Enterprise to +their planet. Captain Kirk accepts the invitation, acutely aware that this +civilization could instantly vaporize the Enterprise if it wanted to. + +But unknown to the crew, these super beings have a fatal weakness. +For all their advanced technology, they have been severed for hundreds +of thousands of years from their physical bodies. As such, they yearn to +feel the rush of physical sensations and long to become human again." +"One of these super beings, in fact, is evil and determined to gain +possession of the physical bodies of the crew. He wants to live like a +human, even if it means destroying the mind of the body’s owner. Soon a +battle breaks out on the deck of the Enterprise, as the evil entity seizes +control of Spock’s body and the crew fights back. + +Scientists have asked themselves, Is there a law of physics preventing +the mind from existing without the body? In particular, if the conscious +human mind is a device that constantly creates models of the world and +simulates them into the future, is it possible to create a machine that can +simulate this entire process? + +Previously, we mentioned the possibility of having our bodies placed +in pods, as in the movie Surrogates, while we mentally control a robot. +The problem here is that our natural body will still gradually wither +away, even if our robot surrogate keeps on going. Serious scientists are" +"contemplating whether we can actually transfer our minds into a robot +so we can become truly immortal. And who wouldn’t want a chance at +eternal life? As Woody Allen once said, “I don’t want to live forever +through my works. I want to live forever by not dying.” + +Actually, millions of people already claim that it is possible for the +mind to leave the body. In fact, many insist that they have done it +themselves. + +OUT-OF-BODY EXPERIENCES + +The idea of minds without bodies is perhaps the oldest of our +superstitions, embedded deep within our myths, folklore, dreams, and + + perhaps even our genes. Every society, it seems, has some tale of ghosts +and demons who can enter and leave the body at will." +"Sadly, many innocents were persecuted to exorcize the demons that +were supposedly possessing their bodies. They probably suffered from +mental illness, such as schizophrenia, in which victims are often haunted +by voices generated by their own minds. Historians believe that one of +the Salem witches who was hung in 1692 for being possessed probably +had a rare genetic condition, called Huntington’s disease, that causes +uncontrolled flailing of the limbs. + +Today some people claim that they have entered a trancelike state in +which their consciousness has left their body and is free to roam +throughout space, even able to look back at their mortal body. In a poll +of thirteen thousand Europeans, 5.8 percent claimed they had had an +out-of-body experience. Interviews with people in the United States +show similar numbers." +"Nobel laureate Richard Feynman, always curious about new +phenomena, once placed himself in a sensory deprivation tank and tried +to leave his physical body. He was successful. He would later write that +he felt that he had left his body, drifted into space, and saw his +motionless body when he looked back. However, Feynman later +concluded that this was probably just his imagination, caused by sensory +deprivation. + +Neurologists who have studied this phenomenon have a more prosaic +explanation. Dr. Olaf Blanke and his colleagues in Switzerland may have" +"located the precise place in the brain that generates out-of-body +experiences. One of his patients was a forty-three-year-old woman who +suffered from debilitating seizures that came from her right temporal +lobe. A grid of about one hundred electrodes was placed over her brain +in order to locate the region responsible for her seizures. When the +electrodes stimulated the area between the parietal and temporal lobes, +she immediately had the sensation of leaving her body. “I see myself +lying in bed, from above, but I only see my legs and lower trunk!” she +exclaimed. She felt she was floating six feet above her body." +"When the electrodes were turned off, however, the out-of-body +sensation disappeared immediately. In fact, Dr. Blanke found that he +could turn the out-of-body sensation on and off, like a light switch, by +repeatedly stimulating this area of the brain. As we saw in Chapter 9, +temporal lobe epileptic lesions can induce the feeling that there are evil +spirits behind every misfortune, so the concept of spirits leaving the +body is perhaps part of our neural makeup. (This may also explain the +presence of supernatural beings. When Dr. Blanke analyzed a twenty- + + two-year-old woman who was suffering from intractable seizures, he +found that, by stimulating the temporoparietal area of the brain, he +could induce the sensation that there was a shadowy presence behind +her. She could describe this person, who even grabbed her arms, in +detail. His position would change with each appearance, but he would +always appear behind her.)" +"Human consciousness, I believe, is the process of continually forming +a model of the world, in order to simulate the future and carry out a +goal. In particular, the brain is receiving sensations from the eyes and +inner ear to create a model of where we are in space. However, when +the signals from our eyes and ears are in contradiction, we become +confused about our location. We often get nauseous and throw up. For +example, many people develop sea sickness when they are on a rocking +boat because their eyes, looking at the cabin walls, tell them that they +are stationary, but their inner ear tells them that they are swaying. The +mismatch between these signals causes them to become nauseous. The +remedy is to look out at the horizon so that the visual image matches the +signals from the inner ear. (This same sense of nausea can be induced +even if you are stationary. If you look at a spinning garbage can with +bright vertical stripes painted on it, the stripes seem to move" +"horizontally across your eyes, giving you the sensation that you are +moving. But your inner ear says you are stationary. The resulting +mismatch causes you to throw up after a few minutes, even if you are +sitting in a chair.) + +The messages from the eyes and inner ear can also be disrupted +electrically, at the boundary of the temporal and parietal lobes, and this +is the origin of out-of-body experiences. When this sensitive area is +touched, the brain gets confused about where it is located in space. +(Notably, temporary loss of blood or oxygen or excess carbon dioxide in +the blood can also cause a disruption in the temporoparietal region and +induce out-of-body experiences, which may explain the prevalence of +these sensations during accidents, emergencies, heart attacks, etc.) + +NEAR-DEATH EXPERIENCES" +"NEAR-DEATH EXPERIENCES + +But perhaps the most dramatic category of out-of-body experiences are +the near-death stories of individuals who have been declared dead but +then mysteriously regained consciousness. In fact, 6 to 12 percent of +survivors of cardiac arrest report having near-death experiences. It’s as +though they have cheated death itself. When interviewed, they have +dramatic tales of the same experience: they left their body and drifted +toward a bright light at the end of a long tunnel." +"The media have seized upon this, with numerous best sellers and TV +documentaries devoted to these theatrical stories. Many bizarre theories +have been proposed to explain near-death experiences. In a poll of two +thousand people, fully 42 percent believed that near-death experiences +were proof of contact with the spiritual world that lies beyond death. +(Some believe that the body releases endorphins—natural narcotics— +before death. This may explain the euphoria that people feel, but not the +tunnel and the bright lights.) Carl Sagan even speculated that near-death +experiences were a reliving of the trauma of birth. The fact that these +individuals recount very similar experiences doesn’t necessarily +corroborate their glimpses into the afterlife; in fact, it seems to indicate +that there is some deep neurological event happening. + +Neurologists have looked into this phenomenon seriously and suspect +that the key may be the decrease of blood flow to the brain that often" +"accompanies near-death cases, and which also occurs in fainting. Dr. +Thomas Lempert, a neurologist at the Castle Park Clinic in Berlin, +conducted a series of experiments on forty-two healthy individuals, +causing them to faint under controlled laboratory conditions. Sixty +percent of them had visual hallucinations (e.g., bright lights and colored +patches). Forty-seven percent of them felt that they were entering +another world. Twenty percent claimed to have encountered a +supernatural being. Seventeen percent saw a bright light. Eight percent +saw a tunnel. So fainting can mimic all the sensations people have in +near-death experiences. But precisely how does this happen?" +"The mystery of how fainting can simulate near-death experiences may +be solved by analyzing the experiences of military pilots. The U.S. Air +Force, for example, contacted neurophysiologist Dr. Edward Lambert to +analyze military pilots who blacked out when experiencing high g forces +(i.e., when executing a tight turn in a jet or pulling out of a dive). Dr. +Lampert placed pilots in an ultracentrifuge at the Mayo Clinic in +Rochester, Minnesota, which spun them around in a circle until they +experienced high g forces. As blood drained from their brain, they would +become unconscious after fifteen seconds of experiencing several g’s of +acceleration." +"He found that after only five seconds, the blood flow to the pilots’ eyes +diminished, so that their peripheral vision dimmed, creating the image +of a long tunnel. This could explain the tunnel that is often seen by +people having a near-death experience. If the periphery of your vision +blacks out, all you see is the narrow tunnel in front of you. But because +Dr. Lampert could carefully adjust the velocity of the centrifuge by +turning a dial, he found he could keep the pilots in this state indefinitely, +allowing him to prove that this tunnel vision is caused by loss of blood +flow to the periphery of the eye. + + CAN CONSCIOUSNESS LEAVE YOUR BODY? + +Some scientists who have investigated near-death and out-of-body +experiences are convinced that they are by-products of the brain itself +when it is placed under stressful conditions and its wiring gets confused. +However, there are other scientists who believe that one day, when our" +"technology is sufficiently advanced decades from now, one’s +consciousness may truly be able to leave the body. Several controversial +methods have been suggested." +"One method has been pioneered by futurist and inventor Dr. Ray +Kurzweil, who believes that consciousness may one day be uploaded into +a supercomputer. We once spoke at a conference together, and he told +me his fascination with computers and artificial intelligence began when +he was five years old and his parents bought him all sorts of mechanical +devices and toys. He loved to tinker with these devices, and even as a +child he knew he was destined to become an inventor. At MIT, he +received his doctorate under Dr. Marvin Minsky, one of the founders of +AI. Afterward, he cut his teeth applying pattern-recognition technology +to musical instruments and text-to-sound machines. He was able to +translate AI research in these areas into a string of companies. (He sold +his first company when he was only twenty.) His optical reader, which +could recognize text and convert it into sound, was heralded as an aid +for the blind, and was even mentioned by Walter Cronkite on the +evening news." +"In order to be a successful inventor, he said to me, you always have to +be ahead of the curve, to anticipate change, not react to it. Indeed, Dr. +Kurzweil loves to make predictions, and many of them have mirrored +the remarkable exponential growth of digital technology. He made the +following predictions: + +• By 2019, a $1,000 PC will have the computing power of the human +brain—twenty million billion calculations per second. (This number +is obtained by taking the one hundred billion neurons of the brain, +multiplying one thousand connections per neuron, and two hundred +calculations per second per connection.) + +• By 2029, a $1,000 PC will be a thousand times more powerful than +the human brain; the human brain itself will be successfully +reversed engineered. + +• By 2055, $1,000 of computing power will equal the processing + + power of all the humans on the planet. (He adds modestly, “I may +be off by a year or two.”)" +"power of all the humans on the planet. (He adds modestly, “I may +be off by a year or two.”) + +In particular, the year 2045 looms as an important one for Dr. +Kurzweil, since that is when he believes the “singularity” will take hold. +By then, he claims, machines will have surpassed humans in intelligence +and in fact will have created next-generation robots even smarter than +themselves. Since this process can continue indefinitely, it means, +according to Dr. Kurzweil, a never-ending acceleration of the power of +machines. In this scenario, we should either merge with our creations or +step out of their way. (Although these dates are in the far future, he told +me that he wants to live long enough to see the day when humans +finally become immortal; that is, he wants to live long enough to live +forever.)" +"As we know from Moore’s law, at a certain point computer power can +no longer advance by creating smaller and smaller transistors. In +Kurzweil’s opinion, the only way to expand computing power further +would be to increase overall size, which would leave robots scavenging +for more computer power by devouring the minerals of the Earth. Once +the planet has become a gigantic computer, robots may be forced to go +into outer space, searching for more sources of computer power. +Eventually, they may consume the power of entire stars. + +I once asked him if this cosmic growth of computers could alter the +cosmos itself. Yes, he replied. He told me that he sometimes looks at the +night sky, wondering if on some distant planet intelligent beings have +already attained the singularity. If so, then perhaps they should leave +some mark on the stars themselves that might be visible to the naked +eye." +"One limitation he told me, is the speed of light. Unless these machines +can break the light barrier, this exponential rise in power may hit a +ceiling. When that happens, says Kurzweil, perhaps they will alter the +laws of physics themselves. + +Anyone who makes predictions with such precision and scope +naturally invites criticism like a lightning rod, but it doesn’t seem to faze +him. People can quibble about this or that prediction, since Kurzweil has +missed some of his deadlines, but he is mainly concerned about the +thrust of his ideas, which predict the exponential growth of technology. +To be fair, most people working in the field of AI whom I have +interviewed agree that some form of a singularity will happen, but they +disagree sharply on when it might occur and how it will unfold. For" +"example, Bill Gates, cofounder of Microsoft, believes that no one alive +today will live to see the day when computers are smart enough to pass +for a human. Kevin Kelly, an editor for Wired magazine, has said, +“People who predict a very utopian future always predict that it is going +to happen before they die.” + +Indeed, one of Kurzweil’s many goals is to bring his father back to life. +Or rather, he wants to create a realistic simulation. There are several +possibilities, but all are still highly speculative. + +Kurzweil proposes that perhaps DNA can be extracted from his father +(from his grave site, relatives, or organic materials he left behind). +Contained within roughly twenty-three thousand genes would be a +complete blueprint to re-create the body of that individual. Then a clone +could be grown from the DNA." +"This is certainly a possibility. I once asked Dr. Robert Lanza of the +company Advanced Cell Technology how he was able to bring a long- +dead creature “back to life,” making history in the process. He told me +that the San Diego Zoo asked him to create a clone of a banteng, an +oxlike creature that had died out about twenty-five years earlier. The +hard part was extracting a usable cell for the purpose of cloning. +However, he was successful, and then he FedExed the cell to a farm, +where it was implanted into a female cow, which then gave birth to this +animal. Although no primate has ever been cloned, let alone a human, +Lanza feels it’s a technical problem, and that it’s only a matter of time +before someone clones a human." +"This would be the easy part, though. The clone would be genetically +equivalent to the original, but without its memories. Artificial memories +might be uploaded to the brain using the pioneering methods described +in Chapter 5, such as inserting probes into the hippocampus or creating +an artificial hippocampus, but Kurzweil’s father has long passed, so it’s +impossible to make the recording in the first place. The best one can do +is to assemble piecemeal all historical data about that person, such as by +interviewing others who possess relevant memories, or accessing their +credit card transactions, etc., and then inputting them into the program. + +A more practical way of inserting a person’s personality and memory +would be to create a large data file containing all known information +about a person’s habits and life. For example, today it is possible to store +all your e-mail, credit card transactions, records, schedules, electronic" +"diaries, and life history onto a single file, which can create a remarkably +accurate picture of who you are. This file would represent your entire +“digital signature,” representing everything that is known about you. It +would be remarkably accurate and intimate, detailing what wines you +like, how you spend vacations, what kind of soap you use, your favorite + + singer, and so on." +"Also, with a questionnaire, it would be possible to create a rough +approximation of Kurzweil’s father’s personality. His friends, relatives, +and associates would fill out a questionnaire containing scores of +questions about his personality, such as whether he was shy, curious, +honest, hardworking, etc. Then they would assign a number to each trait +(e.g., a “10” would mean that you are very honest). This would create a +string of hundreds of numbers, each one ranking a specific personality +trait. Once this vast set of numbers was compiled, a computer program +would take these data and approximate how he would behave in +hypothetical situations. Let’s say that you are giving a speech and are +confronted with an especially obnoxious heckler. The computer program +would then scan the numbers and then predict one of several possible +outcomes (e.g., ignore the heckler, heckle back, or get into a brawl with +the heckler). In other words, his basic personality would be reduced to a" +"the heckler). In other words, his basic personality would be reduced to a +long string of numbers, each from 1 to 10, which can be used by a +computer to predict how he would react to new situations." +"The result would be a vast computer program that would respond to +new situations roughly the way the original person would have, using +the same verbal expressions and having the same quirks, all tempered +with the memories of that person. + +Another possibility would be to forgo the whole cloning process and +simply create a robot resembling the original person. It would then be +straightforward to insert this program into a mechanical device that +looks like you, talks with the same accent and mannerisms, and moves +its arms and limbs the same way that you do. Adding your favorite +expressions (e.g., “you know ...”) would also be easy. + +Of course, today it would be easy to detect that this robot is a fake. +However, in the coming decades, it may be possible to get closer and +closer to the original, so it might be good enough to fool some people. + +But this raises a philosophical question. Is this “person” really the +same as the original? The original is still dead, so the clone or robot is," +"strictly speaking, still an impostor. A tape recorder, for example, might +reproduce a conversation we have with perfect fidelity, but that tape +recorder is certainly not the original. Can a clone or robot that behaves +just like the original be a valid substitute? + +IMMORTALITY + + These methods have been criticized because this process does not +realistically input your true personality and memories. A more faithful +way of putting a mind into a machine is via the Connectome Project, +which we discussed in the last chapter and which seeks to duplicate, +neuron for neuron, all the cellular pathways of your brain. All your +memories and personality quirks are already embedded in the +connectome." +"The Connectome Project’s Dr. Sebastian Seung notes that some people +pay $100,000 or more to have their brains frozen in liquid nitrogen. +Certain animals, like fish and frogs, can be frozen solid in a block of ice +in winter yet be perfectly healthy after thawing out in spring. This is +because they use glucose as an antifreeze to alter the freezing point of +water in their blood. Thus their blood remains liquid, even though they +are encased in solid ice. This high concentration of glucose in the human +body, however, would probably be fatal, so freezing the human brain in +liquid nitrogen is a dubious pursuit because expanding ice crystals would +rupture the cell wall from the inside (and also, as brain cells die, calcium +ions rush in, causing the brain cells to expand until they finally rupture). +In either case, brain cells would most likely not survive the freezing +process." +"Rather than freezing the body and having the cells rupture, a more +reliable process to attain immortality might be to have your connectome +completed. In this scenario, your doctor would have all your neural +connections on a hard drive. Basically, your soul would now be on a +disk, reduced to information. Then at a future point, someone would be +able to resurrect your connectome and, in principle, use either a clone or +a tangle of transistors to bring you back to life. + +The Connectome Project, as we mentioned, is still far from being able +to record a human’s neural connections. But as Dr. Seung says, “Should + +we ridicule the modern seekers of immortality, calling them fools? Or +will they someday chuckle over our graves?” + +MENTAL ILLNESS AND IMMORTALITY" +"MENTAL ILLNESS AND IMMORTALITY + +Immortality may have its drawbacks, however. The electronic brains +being built so far contain only the connections between the cortex and +the thalamus. The reverse-engineered brain, lacking a body, might begin +to suffer from sensory isolation and even manifest signs of mental illness, +as prisoners do when they are placed into solitary confinement. Perhaps +the price of creating an immortal, reverse-engineered brain is madness." +"Subjects who are placed in isolation chambers, where they are +deprived of any contact with the outside world, eventually hallucinate. +In 2008, BBC-TV aired a science program titled Total Isolation, in which +they followed six volunteers as they were placed inside a nuclear bunker, +alone and in complete darkness. After just two days, three of the +volunteers began to see and hear things—snakes, cars, zebras, and +oysters. After they were released, doctors found that all of them suffered +from mental deterioration. One subject’s memory suffered a 36 percent +drop. One can imagine that, after a few weeks or months of this, most of +them might go insane." +"To maintain the sanity of a reverse-engineered brain, it might be +essential to connect it to sensors that receive signals from the +environment so it would be able to see and feel sensations from the +outside world. But then another problem arises: it might feel that it is a +grotesque freak, an unwieldy scientific guinea pig living at the mercy of +a science experiment. Because this brain has the same memory and +personality as the original human, it would crave human contact. And +yet, lurking inside the memory of some supercomputer, with a macabre +jungle of electrodes dangling outside, the reverse-engineered brain +would be repulsive to any human. Bonding with it would be impossible. +Its friends would turn away. + +THE CAVEMAN PRINCIPLE + +At this point, what I call the Caveman Principle starts to kick in. Why do + +so many reasonable predictions fail? And why would someone not want +to live forever inside a computer?" +"The Caveman Principle is this: given a choice between high-tech or +high-touch, we opt for high-touch every time. For example, if we are +given a choice between tickets to see our favorite musician live or a CD +of the same musician in concert, which would we choose? Or if we are +given a choice between tickets to visit the Taj Mahal or just seeing a +beautiful picture of it, which would we prefer? More than likely the live +concert and the airplane tickets. + +This is because we have inherited the consciousness of our apelike +ancestors. Some of our basic personality has probably not changed much +in the last one hundred thousand years, since the first modern humans +emerged in Africa. A large portion of our consciousness is devoted to +looking good and trying to impress members of the opposite sex and our +peers. This is hardwired into our brains. + + More likely, given our basic, apelike consciousness, we will merge +with computers only if this enhances but does not totally replace our +present-day body." +"The Caveman Principle probably explains why some reasonable +predictions about the future never materialized, such as “the paperless +office.” Computers were supposed to banish paper from the office; +ironically, computers have actually created even more paper. This is +because we are descended from hunters who need “proof of the kill” +(i.e., we trust concrete evidence, not ephemeral electrons dancing on a +computer screen that vanish when you turn it off). Likewise, the +“peopleless city,” where people would use virtual reality to go to +meetings instead of commuting, never materialized. Commuting to cities +is worse than ever. Why? Because we are social animals who like to +bond with others. Videoconferencing, although useful, cannot pick up +the full spectrum of subtle information offered via body language. A +boss, for example, may want to ferret out problems in his staff and +therefore wants to see them squirm and sweat under interrogation. You +can do this only in person. + +CAVEMEN AND NEUROSCIENCE" +"CAVEMEN AND NEUROSCIENCE + +When I was a child, I read Isaac Asimov’s Foundation Trilogy and was +deeply influenced by it. First, it forced me to ask a simple question: +What will technology look like fifty thousand years in the future, when +we have a galactic empire? I also couldn’t help wondering throughout +the novel, Why do humans look and act the same as they do now? I +thought that surely thousands of years into the future humans should +have cyborg bodies with superhuman abilities. They should have given +up their puny human forms millennia ago." +"I came up with two answers. First, Asimov wanted to appeal to a +young audience willing to buy his book, so he had to create characters +that those people could identify with, including all their faults. Second, +perhaps people in the future will have the option to have superpowered +bodies but prefer to look normal most of the time. This would be +because their minds have not changed since humans first emerged from +the forest, and so acceptance from their peers and the opposite sex still +determines what they look like and what they want out of life. + +So now let us apply the Caveman Principle to the neuroscience of the +future. At the minimum, it means that any modification of the basic +human form would have to be nearly invisible on the outside. We don’t +want to resemble a refugee from a science-fiction movie, with electrodes +dangling from our head. Brain implants that might insert memories or +increase our intelligence will be adopted only if nanotechnology can" +"make microscopic sensors and probes that are invisible to the naked eye. +In the future, it might be possible to make nanofibers, perhaps made of +carbon nanotubes one molecule thick, so thin that they would be able to +make contact with neurons with surgical precision and yet leave our +appearance unaltered, with our mental capabilities enhanced. + +Meanwhile, if we need to be connected to a supercomputer to upload +information, we won’t want to be tied to a cable jacked into our spinal +cord, as in The Matrix. The connection will have to be wireless so we can +access vast amounts of computer power simply by mentally locating the +nearest server. + +Today we have cochlear implants and artificial retinas that can give +the gift of sound and sight to patients, but in the future our senses will +be enhanced using nanotechnology while we preserve our basic human +form. For instance, we might have the option of enhancing our muscles, +via genetic modification or exoskeletons. There could be a human body" +"shop from which we could order new spare parts as the old ones wear +out, but these and other physical enhancements of the body would have +to avoid abandoning the human form. + +Another way to use this technology in accordance with the Caveman +Principle is to use it as an option, rather than a permanent way of life. +One might want the option of plugging into this technology and then +unplugging soon afterward. Scientists may want to boost their +intelligence to solve a particularly tricky problem. But afterward, they +will be able to take off their helmets or implants and go about their +business. In this way, we are not caught looking like a space cadet to our +friends. The point is that no one would force you to do any of this. We +would want the option of enjoying the benefits of this technology +without the downside of looking silly." +"So in the centuries to come, it is likely our bodies will look very +similar to the ones we possess today, except that they will be perfect and +have enhanced powers. It is a relic of our apelike past that our +consciousness is dominated by ancient desires and wishes. + +But what about immortality? As we have seen, a reverse-engineered +brain, with all the personality quirks of the original person, would +eventually go mad if placed inside a computer. Furthermore, connecting +this brain to external sensors so it could feel sensations from its +environment would create a grotesque monstrosity. One partial solution +to this problem is to connect the reverse-engineered brain to an +exoskeleton. If the exoskeleton acts like a surrogate, then the reverse- +engineered brain would be able to enjoy sensations such as touch and +sight without looking grotesque. Eventually the exoskeleton would go" +"wireless, so that it would act like a human but be controlled by a +reverse-engineered brain “living” inside a computer. + +This surrogate would have the best of both worlds. Being an +exoskeleton, it would be perfect. It would possess superpowers. Since it +would be wirelessly connected to a reverse-engineered brain inside a +large computer, it would also be immortal. And lastly, since it would +sense the environment and look appealingly like a real human, it would +not have as many problems interacting with humans, many of whom +will also have probably opted for this procedure. So the actual +connectome would reside in a stationary supercomputer, although its +consciousness would manifest itself in a perfect, mobile surrogate body. + +All this would require a level of technology far beyond anything that +is attainable today. However, given the rapid pace of scientific progress, +this could become a reality by the end of the century. + +GRADUAL TRANSFERENCE" +"GRADUAL TRANSFERENCE + +Right now the process of reverse engineering involves transferring the +information within the brain, neuron for neuron. The brain has to be cut +up into thin slices, since MRI scans are not yet refined enough to identify +the precise neural architecture of the living brain. So until that can be +done, the obvious disadvantage of this approach is that you have to die +before you can be reversed engineered. Since the brain degenerates +rapidly after death, its preservation would have to take place +immediately, which is very difficult to accomplish." +"But there may be one way to attain immortality without having to die +first. This idea was pioneered by Dr. Hans Moravec, former director of +the Artificial Intelligence Laboratory at Carnegie Mellon University. +When I interviewed him, he told me that he envisions a time in the +distant future when we will be able to reverse engineer the brain for a +specific purpose: to transfer the mind into an immortal robotic body +even while a person is still conscious. If we can reverse engineer every +neuron of the brain, why not create a copy made of transistors, +duplicating precisely the thought processes of the mind? In this way, you +do not have to die in order to live forever. You can be conscious +throughout the entire process." +"He told me that this process would have to be done in steps. First, you +lie on a stretcher, next to a robot lacking a brain. Next, a robotic surgeon +extracts a few neurons from your brain, and then duplicates these +neurons with some transistors located in the robot. Wires connect your +brain to the transistors in the robot’s empty head. The neurons are then + + thrown away and replaced by the transistor circuit. Since your brain +remains connected to these transistors via wires, it functions normally +and you are fully conscious during this process. Then the super surgeon +removes more and more neurons from your brain, each time duplicating +these neurons with transistors in the robot. Midway through the +operation, half of your brain is empty; the other half is connected by + +wires to a large collection of transistors inside the robot’s head. +Eventually all the neurons in your brain have been removed, leaving a +robot brain that is an exact duplicate of your original brain, neuron for +neuron." +"At the end of this process, however, you rise from the stretcher and +find that your body is perfectly formed. You are handsome and beautiful +beyond your dreams, with superhuman powers and abilities. As a perk, +you are also immortal. You gaze back at your original mortal body, +which is just an aging shell without a mind. + +This technology, of course, is far ahead of our time. We cannot reverse +engineer the human brain, let alone make a carbon copy made of +transistors. (One of the main criticisms of this approach is that a +transistorized brain may not fit inside the skull. In fact, given the size of +electronic components, the transistorized brain may be the size of a huge +supercomputer. In this sense, this proposal begins to resemble the +previous one, in which the reverse-engineered brain is stored in a huge +supercomputer, which in turn controls a surrogate. But the great +advantage of this approach is that you don’t have to die; you’d be fully +conscious during the process.)" +"One’s head spins contemplating these possibilities. All of them seem to +be consistent with the laws of physics, but the technological barriers to +achieving them are truly formidable. All these proposals for uploading +consciousness into a computer require a technology that is far into the +future. + +But there is one last proposal for attaining immortality that does not +require reverse engineering the brain at all. It requires simply a +microscopic “nanobot” that can manipulate individual atoms. So why +not live forever in your own natural body, but with a periodic “tune-up” +that makes it immortal? + +WHAT IS AGING? + +This new approach incorporates the latest research into the aging +process. Traditionally there has been no consensus among biologists + + about the source of the aging process. But within the last decade, a new +theory has gained gradual acceptance and has unified many strands of" +"research into aging. Basically, aging is the buildup of errors, at the +genetic and cellular level. As cells get older, errors begin to build up in +their DNA and cellular debris also starts to accumulate, which makes +cells sluggish. As cells begin to slowly malfunction, skin begins to sag, +bones become frail, hair falls out, and our immune system deteriorates. +Eventually, we die. + +But cells also have error-correcting mechanisms. Over time, however, +even these error-correcting mechanisms begin to fail, and aging +accelerates. The goal, therefore, is to strengthen the natural cell-repair +mechanisms, which can be done via gene therapy and the creation of +new enzymes. But there is also another way: using “nanobot” +assemblers." +"One of the linchpins of this futuristic technology is something called +the “nanobot,” or an atomic machine, which patrols the bloodstream, +zapping cancer cells, repairing the damage from the aging process, and +keeping us forever young and healthy. Nature has already created some +nanobots, in the form of immune cells that patrol the body in the blood. +But these immune cells attack viruses and foreign bodies, not the aging +process. + +Immortality is within reach if these nanobots can reverse the ravages +of the aging process at the molecular and cellular level. In this vision, +nanobots are like immune cells, tiny police patrolling your bloodstream. +They attack any cancer cells, neutralize viruses, and clean out the debris +and mutations. Then the possibility of immortality would be within +reach using our own bodies, not some robot or clone. + +NANOBOTS—REAL OR FANTASY?" +"NANOBOTS—REAL OR FANTASY? + +My own personal philosophy is that if something is consistent with the +laws of physics, then it becomes an engineering and economics problem +to build it. The engineering and economic hurdles may be formidable, of +course, making it impractical for the present, but nonetheless it is still +possible. + +On the surface, the nanobot is simple: an atomic machine with arms +and clippers that grabs molecules, cuts them at specific points, and then +splices them back together. By cutting and pasting various atoms, the" +"nanobot can create almost any known molecule, like a magician pulling +something out of a hat. It can also self-reproduce, so it is necessary to +build only one nanobot. This nanobot will then take raw materials, +digest them, and create millions of other nanobots. This could trigger a +second Industrial Revolution, as the cost of building materials plummets. +One day, perhaps every home will have its own personal molecular +assembler, so you can have anything you want just by asking for it." +"But the key question is: Are nanobots consistent with the laws of +physics? Back in 2001, two visionaries practically came to blows over +this crucial question. At stake was nothing less than a vision of the entire +future of technology. On one side was the late Richard Smalley, a Nobel +laureate in chemistry and skeptical of nanobots. On the other side was +Eric Drexler, one of the founding fathers of nanotechnology. Their +titanic, tit-for-tat battle played out in the pages of several scientific +magazines from 2001 to 2003." +"Smalley said that, at the atomic scale, new quantum forces emerge +that make nanobots impossible. The error made by Drexler and others, +he claimed, is that the nanobot, with its clippers and arms, cannot +function at the atomic scale. There are novel forces (e.g., the Casimir +force) that cause atoms to repel or attract one another. He called this the +“sticky, fat fingers” problem, because the fingers of the nanobot are not +like delicate, precise pliers and wrenches. Quantum forces get in the +way, so it’s like trying to weld metals together while wearing gloves that +are many inches thick. Furthermore, every time you try to weld two +pieces of metal together, these pieces are either repelled or stick to you, +so you can never grab one properly." +"Drexler then fired back, stating that nanobots are not science fiction— +they actually exist. Think of the ribosomes in our own body. They are +essential in creating and molding DNA molecules. They can cut and +splice DNA molecules at specific points, which makes possible the +creation of new DNA strands. + +But Smalley wasn’t satisfied, stating that ribosomes are not all-purpose +machines that can cut and paste anything you want; they work +specifically on DNA molecules. Moreover, ribosomes are organic +chemicals that need enzymes to speed up the reaction, which occurs +only in a watery environment. Transistors are made of silicon, not water, +so these enzymes would never work, he concluded. Drexel, in turn, + +mentioned that catalysts can work even without water. This heated +exchange went back and forth through several rounds. In the end, like +two evenly matched prizefighters, both sides seemed exhausted. Drexler +had to admit that the analogy to workers with cutters and blowtorches" +"was too simplistic, that quantum forces do get in the way sometimes. But +Smalley had to concede that he was unable to score a knockout blow. +Nature had at least one way of evading the “sticky, fat fingers” problem, +with ribosomes, and perhaps there might be other subtle, unforeseen +ways as well. + +Regardless of the details of this debate, Ray Kurzweil is convinced that +these nanobots, whether or not they have fat, sticky fingers, will one day +shape not just molecules, but society itself. He summarized his vision +when he said, “I’m not planning to die.... I see it, ultimately, as an +awakening of the whole universe. I think the whole universe right now is +basically made up of dumb matter and energy and I think it will wake +up. But if it becomes transformed into this sublimely intelligent matter +and energy, I hope to be part of that.”" +"As fantastic as these speculations are, they are only a preface to the +next leap in speculation. Perhaps one day the mind will not only be free +of its material body, it will also be able to explore the universe as a +being of pure energy. The idea that consciousness will one day be free to +roam among the stars is the ultimate dream. As incredible as it may +sound, this is well within the laws of physics. + +13 THE MIND AS PURE ENERGY + +The idea that one day consciousness may spread throughout the +universe has been considered seriously by physicists. Sir Martin Rees, the +Royal Astronomer of Great Britain, has written, “Wormholes, extra +dimensions, and quantum computers open up speculative scenarios that +could transform our entire universe eventually into a ‘living cosmos’!”" +"But will the mind one day be freed of its material body to explore the +entire universe? This was the theme explored in Isaac Asimov’s classic +science-fiction tale “The Last Question.” (He would fondly recall that this +was his favorite science-fiction short story of all the ones he had +written.) In it, billions of years into the future, humans will have placed +their physical bodies in pods on an obscure planet, freeing their minds to +control pure energy throughout the galaxy. Instead of surrogates made +of steel and silicon, these surrogates are pure energy beings that can +effortlessly roam the distant reaches of space, past exploding stars, +colliding galaxies, and other wonders of the universe. But no matter how +powerful humanity has become, it is helpless as it witnesses the ultimate +death of the universe itself in the Big Freeze. In desperation, humanity +constructs a supercomputer to answer the final question: Can the death" +"constructs a supercomputer to answer the final question: Can the death +of the universe be reversed? The computer is so large and complex that +it has to be placed in hyperspace. But the computer simply responds that +there is insufficient information to give an answer." +"Eons later, as the stars begin to turn dark, all life in the universe is +about to die. But then the supercomputer finally discovers a way to +reverse the death of the universe. It collects dead stars from across the +universe, combines them into one gigantic cosmic ball, and ignites it. As +the ball explodes, the supercomputer announces, “Let there be light!” + +And there was light. + +So humanity, once freed of the physical body, is capable of playing +God and creating a new universe. + +At first, Asimov’s fantastic tale of beings made of pure energy roaming + +across the universe sounds impossible. We are accustomed to thinking of +beings made of flesh and blood, which are at the mercy of the laws of +physics and biology, living and breathing on Earth, and bound by the +gravity of our planet. The concept of conscious entities of energy, +soaring across the galaxy, unimpeded by the limitations of material +bodies, is a strange one." +"Yet this dream of exploring the universe as beings of pure energy is +well within the laws of physics. Think of the most familiar form of pure +energy, a laser beam, which is capable of containing vast amounts of +information. Today trillions of signals in the form of phone calls, data +packages, videos, and e-mail messages are transmitted routinely by fiber¬ +optic cables carrying laser beams. One day, perhaps sometime in the +next century, we will be able to transmit the consciousness of our brains +throughout the solar system by placing our entire connectomes onto +powerful laser beams. A century beyond that, we may be able to send +our connectome to the stars, riding on a light beam." +"(This is possible because the wavelength of a laser beam is +microscopic, i.e., measured in millionths of a meter. That means you can +compress vast amounts of information on its wave pattern. Think of +Morse code. The dots and dashes of Morse code can easily be +superimposed on the wave pattern of a laser beam. Even more +information can be transferred onto a beam of X-rays, which has a +wavelength even smaller than an atom.) + +One way to explore the galaxy, unbound by the messy restrictions of +ordinary matter, is to place our connectomes onto laser beams directed +at the moon, the planets, and even the stars. Given the crash program to +find the pathways of the brain, the complete connectome of the human +brain will be available late in this century, and a form of the connectome +capable of being placed on a laser beam might be available in the next +century." +"The laser beam would contain all the information necessary to +reassemble a conscious being. Although it may take years or even +centuries for the laser beam to reach its destination, from the point of +view of the person riding on the laser beam, the trip would be +instantaneous. Our consciousness is essentially frozen on the laser beam +as it soars through empty space, so the trip to the other side of the +galaxy appears to take place in the blink of an eye." +"In this way, we avoid all the unpleasant features of interplanetary and +interstellar travel. First, there is no need to build colossal booster +rockets. Instead, you simply press the “on” button of a laser. Second, +there are no powerful g forces crushing your body as you accelerate into +space. Instead, you are boosted instantly to the speed of light, since you +are immaterial. Third, you don’t have to suffer the hazards of outer +space, such as meteor impacts and deadly cosmic rays, since asteroids +and radiation pass right through you harmlessly. Fourth, you don’t have +to freeze your body or endure years of boredom as you lumber tediously +inside a conventional rocket. Instead, you zip across space at the fastest +velocity in the universe, frozen in time." +"Once we reach our destination, there would have to be a receiving +station to transfer the data of the laser beam onto a mainframe +computer, which then brings the conscious being back to life. The code +that was imprinted onto the laser beam now takes control of the +computer and redirects its programming. The connectome directs the +mainframe computer to begin simulating the future to attain its goals +(i.e., it becomes conscious). + +This conscious being inside the mainframe then sends signals +wirelessly to a robotic surrogate body, which has been waiting for us at +the destination. In this way, we suddenly “wake up” on a distant planet +or star, as if the trip took place in the blink of an eye, inside the robotic +body of our surrogate. All the complex computations take place in a +large mainframe computer, which directs the movements of a surrogate +to carry on with our business on a distant star. We are oblivious to the +hazards of space travel, as if nothing had happened." +"Now imagine a vast network of these stations spread out over the solar +system and even the galaxy. From our point of view, hopping from star +to star would be almost effortless, traveling at the speed of light in +journeys that are instantaneous. At each station, there is a robotic +surrogate waiting for us to enter its body, just like an empty hotel room +waiting for us to check in. We arrive at our destination refreshed and +equipped with a superhuman body. + +The type of surrogate robotic body that awaits us at the end of this + + journey would depend on the mission. If the job is to explore a new +world, then the surrogate body would have to work in harsh conditions. +It would have to adjust to a different gravitational field, a poisonous + +atmosphere, freezing-cold or blistering-hot temperatures, different day- +night cycles, and a constant rain of deadly radiation. To survive under +these harsh conditions, the surrogate body would have to have super +strength and super senses." +"If the surrogate body is purely for relaxation, then it would be +designed for leisurely activities. It would maximize the pleasure of +soaring through space on skis, surfboards, kites, gliders, or planes, or of +sending a ball through space propelled by the swing of a bat, club, or +racket. + +Or if the job is to mingle with and study the local natives, then the +surrogate would approximate the bodily characteristics of the indigenous +population (as in the movie Avatar )." +"Admittedly, in order to create this network of laser stations in the first +place, it might be necessary first to travel to the planets and stars in the +old-fashioned way, in more conventional rocket ships. Then one could +build the first set of these laser stations. (Perhaps the fastest, cheapest, +and most efficient way of creating this interstellar network would be to +send self-replicating robotic probes throughout the galaxy. Because they +can make copies of themselves, starting with one such probe, after many +generations there would be billions of such probes streaming out in all +directions, each one creating a laser station wherever it lands. We will +discuss this further in the next chapter.) + +But once the network is fully established, one can conceive of a +continual stream of conscious beings roaming the galaxy, so that at any +time crowds of people are leaving and arriving from distant parts of the +galaxy. Any laser station in the network might look like Grand Central +Station." +"As futuristic as this may sound, the basic physics for this concept are +already well established. This includes placing vast amounts of data onto +laser beams, sending this information across thousands of miles, and +then decoding the information at the other end. The major problems +facing this idea are therefore not in the physics, but in the engineering. +Because of this, it may take us until the next century to send our entire +connectome on laser beams powerful enough to reach the planets. It +might take us still another century to beam our minds to the stars. + +To see if this is feasible, it is instructive to do a few simple, back-of- +the-envelope calculations. The first problem is that the photons inside a" +"pencil-thin laser beam, although they appear to be in perfectly parallel +formation, actually diverge slightly in space. (When I was a child, I used +to shine a flashlight at the moon and wonder if the light ever reached it. +The answer is yes. The atmosphere absorbs over 90 percent of the +original beam, leaving some remaining to reach the moon. But the real +problem is that the image the flashlight finally casts on the moon is +miles across. This is because of the uncertainty principle; even laser +beams must diverge slowly. Since you cannot know the precise location +of the laser beam, it must, by the laws of quantum physics, slowly spread +out over time.)" +"But beaming our connectomes to the moon does not give us much +advantage, since it’s easier simply to remain on Earth and control the +lunar surrogate directly by radio. The delay is only about a second when +issuing commands to the surrogate. The real advantage comes when +controlling surrogates on the planets, since a radio message may take +hours to reach a surrogate there. The process of issuing a series of radio +commands to a surrogate, waiting for a response, and issuing another +command would be painfully slow, taking days on end. + +If you want to send a laser beam to the planets, you first have to +establish a battery of lasers on the moon, well above the atmosphere, so +there is no air to absorb the signal. Shot from the moon, a laser beam to +the planets could arrive in a matter of minutes to a few hours. Once the +laser beam has sent the connectome to the planets, then it’s possible to +directly control the surrogate without any delay factors at all." +"So establishing a network of these laser stations throughout the solar +system could be accomplished by the next century. But the problems are +magnified when we try sending the beam to the stars. This means that +we must have relay stations placed on asteroids and space stations along +the way, in order to amplify the signal, reduce errors, and send the +message to the next relay station. This could potentially be done by +using the comets that lie between our sun and the nearby stars. For +example, extending about a light-year from the sun (or one-quarter of +the distance to the nearest star) is the Oort cloud of comets. It is a +spherical shell of billions of comets, many of which lie motionless in +empty space. There is probably a similar Oort cloud of comets +surrounding the Centauri star system, which is our nearest stellar +neighbor. Assuming that this Oort cloud also extends a light-year from" +"those stars, then fully half the distance from our solar system to the next +contains stationary comets on which we can build laser relay stations. + + Another problem is the sheer amount of data that must be sent by +laser beam. The total information contained in one’s connectome, +according to Dr. Sebastian Seung, is roughly one zettabyte (that is, a 1 +with twenty-one zeros after it). This is roughly equivalent to the total +information contained in the World Wide Web today. Now consider +shooting a battery of laser beams into space carrying this vast mountain +of information. Optical fibers can carry terabytes of data per second (a 1 +with twelve zeros after it). Within the next century, advances in +information storage, data compression, and bundling of laser beams may +increase this efficiency by a factor of a million. This means that it would +take a few hours or so to send the beam into space carrying all the +information contained within the brain." +"So the problem is not the sheer amount of data sent on laser beams. In +principle, laser beams can carry an unlimited amount of data. The real +bottlenecks are the receiving stations at either end, which must have +switches that rapidly manipulate this amount of data at blinding speed. +Silicon transistors may not be fast enough to handle this volume of data. +Instead, we might have to use quantum computers, which compute not +on silicon transistors but on individual atoms. At present, quantum +computers are at a primitive level, but by the next century they might be +powerful enough to handle zettabytes of information. + +FLOATING BEINGS OF ENERGY" +"FLOATING BEINGS OF ENERGY + +Another advantage of using quantum computers to process this +mountain of data is the chance to create beings of energy that can hover +and float in the air, which appear frequently in science fiction and +fantasy. These beings would represent consciousness in its purest form. +At first, however, they may seem to violate the laws of physics, since +light always travels at the speed of light. + +But in the last decade, headlines were made by physicists at Harvard +University who announced that they were able to stop a beam of light +dead in its tracks. These physicists apparently accomplished the +impossible, slowing down a light beam to a leisurely pace until it could" +"be placed in a bottle. Capturing a light beam in a bottle is not so +fantastic if you look carefully at a glass of water. As a light beam enters +the water, it slows down, bending as it enters the water at an angle. +Similarly, light bends as it enters glass, making telescopes and +microscopes possible. The reason for all this comes from the quantum +theory. + +Think of the old Pony Express, which delivered the mail in the" +"Think of the old Pony Express, which delivered the mail in the + + nineteenth century in the American West. Each pony could sprint +between relay stations at great speed. But the bottleneck was the delay +factor at each relay station, where the mail, rider, and pony had to be +exchanged. This slowed down the average velocity of the mail +considerably. In the same way, in the vacuum between atoms, light still +travels at c, the speed of light, which is roughly 186,282 miles per second. +However, when it hits atoms, light is delayed; it is briefly absorbed and +then reemitted by atoms, sending it on its way a fraction of a second +later. This slight delay is responsible for light beams, on average, +apparently slowing down in glass or water." +"The Harvard scientists exploited this phenomenon, taking a container +of gas and carefully cooling it down to near absolute zero. At these +freezing temperatures, the gas atoms absorbed a light beam for longer +and longer time periods before reemitting it. Thus, by increasing this +delay factor, they could slow down the light beam until it came to rest. +The light beam still traveled at the speed of light between the gas atoms, +but it spent an increasing amount of time being absorbed by them. + +This raises the possibility that a conscious being, instead of assuming +control of a surrogate, may prefer to remain in the form of pure energy +and roam, almost ghostlike, as pure energy." +"So in the future, as laser beams are sent to the stars containing our +connectomes, the beam may be transferred into a cloud of gas molecules +and then contained in a bottle. This “bottle of light” is very similar to a +quantum computer. Both of them have a collection of atoms vibrating in +unison, in which the atoms are in phase with one another. And both of +them can do complex computations that are far beyond an ordinary +computer’s capability. So if the problems of quantum computers can be +solved, it may also give us the ability to manipulate these “bottles of +light.” + +FASTER THAN LIGHT? + +We see, then, that all these problems are ones of engineering. There is no +law of physics preventing traveling on an energy beam in the next +century or beyond. So this is perhaps the most convenient way of +visiting the planets and stars. Instead of riding on a light beam, as the +poets dreamed, we become the light beam." +"To truly realize the vision expressed in Asimov’s science-fiction tale, +we need to ask if faster-than-light intergalactic travel is truly possible. In +his short story, beings of immense power move freely between galaxies +separated by millions of light-years. + + Is this possible? To answer this question, we have to push the very +boundaries of modern quantum physics. Ultimately, things called +“wormholes” may provide a shortcut through the vastness of space and +time. And beings made of pure energy rather than matter would have a +decisive advantage in passing through them." +"Einstein, in some sense, is like the cop on the block, stating that you +cannot go faster than light, the ultimate velocity in the universe. +Traveling across the Milky Way galaxy, for example, would take one +hundred thousand years, even sailing on a laser beam. Although only an +instant of time has passed for the traveler, the time on the home planet +has progressed one hundred thousand years. And passing between +galaxies involves millions to billions of light-years. + +But Einstein himself left a loophole in his work. In his general theory +of relativity of 1915, he showed that gravity arose from the warping of +space-time. Gravity is not the “pull” of a mysterious invisible force, as +Newton once thought, but actually a “push” caused by space itself +bending around an object. Not only did this brilliantly explain the +bending of starlight passing near stars and the expansion of the universe, +it left open the possibility of the fabric of space-time stretching until it +ripped." +"In 1935, Einstein and his student Nathan Rosen introduced the +possibility that two black-hole solutions could be joined back to back, +like Siamese twins, so if you fell into one black hole, you could, in +principle, pass out of the other one. (Imagine joining two funnels at their +ends. Water that drains through one funnel emerges from the other.) +This “wormhole,” also called the Einstein-Rosen Bridge, introduced the + +possibility of portals or gateways between universes. Einstein himself +dismissed the possibility that you could pass through a black hole, since +you would be crushed in the process, but several subsequent +developments have raised the possibility of faster-than-light travel +through a wormhole." +"First, in 1963, mathematician Roy Kerr discovered that a spinning +black hole does not collapse into a single dot, as previously thought, but +into a rotating ring, spinning so fast that centrifugal forces prevent it +from collapsing. If you fell through the ring, then you could pass into +another universe. The gravitational forces would be large, but not +infinite. This would be like Alice’s Looking Glass, where you could pass +your hand through the mirror and enter a parallel universe. The rim of +the Looking Glass would be the ring forming the black hole itself. Since +Kerr’s discovery, scores of other solutions of Einstein’s equations have +shown that you can, in principle, pass between universes without being +immediately crushed. Since every black hole seen so far in space is + + spinning rapidly (some of them clocked at one million miles per hour), +this means that these cosmic gateways could be commonplace." +"In 1988, physicist Dr. Kip Thorne of Cal Tech and his colleagues +showed that, with enough “negative energy,” it might be possible to +stabilize a black hole so that a wormhole becomes “transversable” (i.e., +you can freely pass through it both ways without being crushed). +Negative energy is perhaps the most exotic substance in the universe, +but it actually exists and can be created (in microscopic quantities) in +the laboratory. + +So here is the new paradigm. First, an advanced civilization would +concentrate enough positive energy at a single point, comparable to a +black hole, to open up a hole through space connecting two distant +points. Second, it would amass enough negative energy to keep the +gateway open, so that it is stable and does not close the instant you enter +it." +"We can now put this idea into proper perspective. Mapping the entire +human connectome should be possible late in this century. An +interplanetary laser network could be established early in the next +century, so that consciousness can be beamed across the solar system. No +new law of physics would be required. A laser network that can go +between the stars may have to wait until the century after that. But a + +civilization that can play with wormholes will have to be thousands of +years ahead of us in technology, stretching the boundaries of known +physics." +"All this, then, has direct implications for whether consciousness can +pass between universes. If matter comes close to a black hole, the gravity +becomes so intense that your body becomes “spaghettified.” The gravity +pulling on your leg is greater than the gravity pulling on your head, so +your body is stretched by tidal forces. In fact, as you approach the black +hole, even the atoms of your body are stretched until the electrons are +ripped from the nuclei, causing your atoms to disintegrate." +"(To see the power of tidal forces, just look at the tides of Earth and the +rings of Saturn. The gravity of the moon and sun exert a pull on Earth, +causing the oceans to rise several feet during high tide. And if a moon +comes too close to a giant planet like Saturn, the tidal forces will stretch +the moon and eventually tear it apart. The distance at which moons get +ripped apart by tidal forces is called the Roche limit. The rings of Saturn +lie exactly at the Roche limit, so they might have been caused by a moon +that wandered too close to the mother planet.) + +Even if we enter a spinning black hole and use negative energy to + + stabilize it, then, the gravity fields still might be so powerful that we’d +be spaghettified." +"stabilize it, then, the gravity fields still might be so powerful that we’d +be spaghettified. + +But here is where laser beams have an important advantage over +matter when passing through a wormhole. Laser light is immaterial, so it +cannot be stretched by tidal forces as it passes near a black hole. Instead, +light becomes “blue-shifted” (i.e., it gains energy and its frequency +increases). Even though the laser beam is distorted, the information +stored on it is untouched. For example, a message in Morse code carried +by a laser beam becomes compressed, but the information content +remains unchanged. Digital information is untouched by tidal forces. So +gravitational forces, which can be fatal to beings made of matter, may be +harmless to beings traveling on light beams. + +In this way, consciousness carried by a laser beam, because it is +immaterial, has a decisive advantage over matter in passing through a +wormhole." +"Laser beams have another advantage over matter when passing +through a wormhole. Some physicists have calculated that a microscopic +wormhole, perhaps the size of an atom, might be easier to create. Matter + +would not be able to pass through such a tiny wormhole. But X-ray +lasers, with a wavelength smaller than an atom, might possibly be able +to pass through without difficulty." +"Although Asimov’s brilliant short story was clearly a work of fantasy, +ironically a vast interstellar network of laser stations might already exist +within the galaxy, yet we are so primitive that we are totally unaware of +it. To a civilization thousands of years ahead of us, the technology to +digitalize their connectomes and send them to the stars would be child’s +play. In that case, it is conceivable that intelligent beings are already +zapping their consciousness across a vast network of laser beams in the +galaxy. Nothing we observe with our most advanced telescopes and +satellites prepares us to detect such an intergalactic network. + +Carl Sagan once lamented the possibility that we might live in a world +surrounded by alien civilizations and not have the technology to realize +it. + +Then the next question is: What lurks in the alien mind?" +"Then the next question is: What lurks in the alien mind? + +If we were to encounter such an advanced civilization, what kind of +consciousness might it have? One day, the destiny of the human race +may rest on answering this question. + + Sometimes I think that the surest sign that intelligent life exists +elsewhere in the universe is that none of it has tried to contact +us. + +—BILL WATTERSON + +Either intelligent life exists in outer space or it doesn’t. Either +thought is frightening. + +—ARTHUR C. CLARKE + +14 THE ALIEN MIND" +"—ARTHUR C. CLARKE + +14 THE ALIEN MIND + +In War of the Worlds by H. G. Wells, aliens from Mars attack Earth +because their home planet is dying. Armed with death rays and giant +walking machines, they quickly incinerate many cities and are on the +verge of seizing control of Earth’s major capitals. Just as the Martians +are crushing all signs of resistance and our civilization is about to be +reduced to rubble, they are mysteriously stopped cold in their tracks. +With all their advanced science and weaponry, they failed to factor in an +onslaught from the lowliest of creatures: our germs." +"That single novel created an entire genre, launching a thousand +movies like Earth vs. the Flying Saucers and Independence Day. Most +scientists cringe, however, when they see how the aliens are described. +In the movies, aliens are often depicted as creatures with some sense of +human values and emotions. Even with glowing green skin and huge +heads, they still look like us to a certain degree. They also tend to speak +perfect English. + +But, as many scientists have pointed out, we may have much more in +common with a lobster or a sea slug than we do with an alien from +space." +"As with silicon consciousness, alien consciousness will most likely +have the general features described in our space-time theory; that is, the +ability to make a model of the world and then calculate how it will +evolve in time to achieve a goal. But while robots can be programmed so +that they emotionally bond with humans and have goals compatible +with ours, alien consciousness may have neither. It’s likely to have its +own set of values and goals, independent of humanity. One can only +speculate what these might be. + +Physicist Dr. Freeman Dyson of the Institute for Advanced Study at + + Princeton was a consultant to the movie 2001 . When he finally saw the +movie, he was delighted, not because of its dazzling special effects, but +because it was the first Hollywood movie ever to present an alien" +"consciousness, with desires, goals, and intentions totally foreign to ours. +For the first time, the aliens were not simply human actors flailing +about, trying to act menacing in cheesy monster costumes. Instead, alien +consciousness was presented as something totally orthogonal to human +experience, something entirely outside our ken. + +In 2011, Stephen Hawking raised another question. The noted +cosmologist made headlines when he said that we must be prepared for +a possible alien attack. He said that if we ever encounter an alien +civilization, it will be more advanced than ours and hence will pose a +mortal threat to our very existence." +"We have only to see what happened to the Aztecs when they +encountered the bloodthirsty Hernan Cortes and his conquistadors to +imagine what might happen with such a fateful encounter. Armed with +technology that the Bronze Age Aztecs had never seen before, such as +iron swords, gunpowder, and the horse, this small band of cutthroats +was able to crush the ancient Aztec civilization in a matter of months in +1521. + +All this raises these questions: What will alien consciousness be like? +How will their thinking process and goals differ from ours? What do +they want? + +FIRST CONTACT IN THIS CENTURY + +This is not an academic question. Given the remarkable advances in +astrophysics, we may actually make contact with an alien intelligence in +the coming decades. How we respond to them could determine one of +the most pivotal events in human history. + +Several advances are making this day possible." +"Several advances are making this day possible. + +First, in 2011 the Kepler satellite, for the first time in history, gave +scientists a “census” of the Milky Way galaxy. After analyzing light from +thousands of stars, the Kepler satellite found that one in two hundred +might harbor an earthlike planet in the habitable zone. For the first time, +we can therefore calculate how many stars within the Milky Way galaxy +might be earthlike: about a billion. As we look at the distant stars, we +have genuine reason to wonder if anyone is looking back at us. + + So far, more than one thousand exoplanets have been analyzed in" +"So far, more than one thousand exoplanets have been analyzed in + +detail by earthbound telescopes. (Astronomers find them at the rate of +about two exoplanets per week.) Unfortunately, nearly all of them are +Jupiter-size planets, probably devoid of any earthlike creatures, but +there are a handful of “super earths,” rocky planets that are a few times +larger than Earth. Already, the Kepler satellite has identified about 2,500 +candidate exoplanets in space, a handful of which look very much like +Earth. These planets are at just the right distance from their mother stars +so that liquid oceans can exist. And liquid water is the “universal +solvent” that dissolves most organic chemicals like DNA and proteins." +"In 2013, NASA scientists announced their most spectacular discovery +using the Kepler satellite: two exoplanets that are near twins of Earth. +They are located 1,200 light-years away in the constellation Lyra. They +are only 60 percent and 40 percent larger than Earth. More important, +both lie within the habitable zone of their mother star, so there is a +possibility that they have liquid oceans. Of all the planets analyzed so +far, they are the closest to being mirror images of Earth. + +Furthermore, the Hubble Space Telescope has given us an estimate of +the total number of galaxies in the visible universe: one hundred billion. +Therefore, we can calculate the number of earthlike planets in the visible +universe: one billion times one hundred billion, or one hundred +quintillion earthlike planets." +"This is a truly astronomical number, so the odds of life existing in the +universe are astronomically large, especially when you consider that the +universe is 13.8 billion years old, and there has been plenty of time for +intelligent empires to rise—and perhaps fall. In fact, it would be more +miraculous if another advanced civilization did not exist. + +SETI AND ALIEN CIVILIZATIONS + +Second, radio telescope technology is becoming more sophisticated. So +far, only about one thousand stars have been closely analyzed for signs +of intelligent life, but in the coming decade this number could rise by a +factor of one million. + +Using radio telescopes to hunt for alien civilizations dates back to +1960, when astronomer Frank Drake initiated Project Ozma (after the +Queen of Oz), using the twenty-five-meter radio telescope in Green" +"Bank, West Virginia. This marked the birth of the SETI project (the +Search for Extraterrestrial Intelligence). Unfortunately, no signals from +aliens were picked up, but in 1971 NASA proposed Project Cyclops, +which was supposed to have 1,500 radio telescopes at a cost of $10 +billion. + +Not surprisingly, it never went anywhere. Congress was not amused. + +Funding did become available for a much more modest proposal: to +send a carefully coded message in 1971 to aliens in outer space. A coded +message containing 1,679 bits of information was transmitted via the +giant Arecibo radio telescope in Puerto Rico toward the Globular Cluster +Ml 3, about 25,100 light-years away. It was the world’s first cosmic +greeting card, containing relevant information about the human race. +But no reply message was received. Perhaps the aliens were not +impressed with us, or possibly the speed of light got in the way. Given +the large distances involved, the earliest date for a reply message would +be 52,174 years from now." +"Since then, some scientists have expressed misgivings about +advertising our existence to aliens in space, at least until we know their +intentions toward us. They disagree with the proponents of the METI +Project (Messaging to Extra-Terrestrial Intelligence) who actively +promote sending signals to alien civilizations in space. The reasoning +behind the METI Project is that Earth already sends vast amounts of +radio and TV signals into outer space, so a few more messages from the +METI Project will not make much difference. But the critics of METI +believe that we should not needlessly increase our chances of being +discovered by potentially hostile aliens." +"In 1995, astronomers turned to private sources to start the SETI +Institute in Mountain View, California, to centralize research and initiate +Project Phoenix, which is trying to study one thousand nearby sunlike +stars in the l,200-to-3,000-megahertz radio range. The equipment is so +sensitive that it can pick up the emissions from an airport radar system +two hundred light-years away. Since its founding, the SETI Institute has +scanned more than one thousand stars at a cost of $5 million per year, +but still no luck. + +A more novel approach is the SETI@home project, initiated by +astronomers at the University of California at Berkeley in 1999, which +uses an informal army of millions of amateur PC owners. Anyone can + +join in this historic hunt. While you are sleeping at night, your screen +saver crunches some of the data pouring in from the Arecibo radio +telescope in Puerto Rico. So far, it has signed up 5.2 million users in 234 +countries; perhaps these amateurs dream that they will be the first in" +"human history to make contact with alien life. Like Columbus’s, their +names may go down in history. The SETI @home project has grown so +rapidly that it is, in fact, the largest computer project of this type ever +undertaken. + +When I interviewed Dr. Dan Wertheimer, director of SETI@home, I +asked him how they can distinguish false messages from real ones. He +said something that surprised me. He told me that they sometimes +deliberately “seed” the data from radio telescopes with fake signals from +an imaginary intelligent civilization. If no one picks up these fake +messages, then they know that there is something wrong with their +software. The lesson here is that if your PC screen saver announces that +it has deciphered a message from an alien civilization, please do not +immediately call the police or the president of the United States. It might +be a fake message. + +ALIEN HUNTERS" +"ALIEN HUNTERS + +One colleague of mine who has dedicated his life to finding intelligent +life in outer space is Dr. Seth Shostak, director of the SETI Institute. With +his Ph.D. in physics from the California Institute of Technology, I might +have expected him to become a distinguished physics professor lecturing +to eager Ph.D. students, but instead he spends his time in an entirely +different fashion: asking for donations to the SETI Institute from wealthy +individuals, poring over possible signals from outer space, and doing a +radio show. I once asked him about the “giggle factor”—do fellow +scientists giggle when he tells them that he listens to aliens from outer +space? Not anymore, he claims. With all the new discoveries in +astronomy, the tide has turned." +"In fact, he even sticks his neck out and says flatly that we will make +contact with an alien civilization in the very near future. He has gone on +record as proclaiming that the 350-antenna Allen Telescope Array now +being built “will trip across a signal by the year 2025.” + +Isn’t that a bit risky, I asked him? What makes him so sure? One factor +working in his favor has been the explosion in the number of radio +telescopes in the last few years. Although the U.S. government does not +fund his project, the SETI Institute recently hit pay dirt when it +convinced Paul Allen (the Microsoft billionaire) to donate over $30 +million in funds to start the Allen Telescope Array at Hat Creek, +California, 290 miles north of San Francisco. It currently scans the +heavens with 42 radio telescopes, and eventually will reach up to 350. +(One problem, however, is the chronic lack of funding for these scientific +experiments. To make up for budget cuts, the Hat Creek facility is kept" +"alive through partial funding from the military.) + +One thing, he confessed to me, makes him squirm a bit, and that is +when people confuse the SETI Project with UFO hunters. The former, he +claims, is based on solid physics and astronomy, using the latest in +technology. The latter, however, base their theories on anecdotal +hearsay evidence that may or may not be based on truth. The problem is +that the mass of UFO sightings he gets in the mail are not reproducible +or testable. He urges anyone who claims to have been abducted by aliens +in a flying saucer to steal something—an alien pen or paperweight, for +example—to prove your case. Never leave a UFO empty-handed, he told +me." +"He also concludes that there is no firm evidence that aliens have +visited our planet. I then asked him whether he thought the U.S. +government was deliberately covering up evidence of an alien +encounter, as many conspiracy theorists believe. He replied, “Would +they really be so efficient at covering up a big thing like this? +Remember, this is the same government that runs the post office.” + +DRAKE’S EQUATION + +When I asked Dr. Wertheimer why he is so sure that there is alien life in +outer space, he replied that the numbers are in his favor. Back in 1961, +astronomer Frank Drake tried to estimate the number of such intelligent +civilizations by making plausible assumptions. If we start with the +number one hundred billion, the number of stars in the Milky Way +galaxy, then we can estimate the fraction of them that are similar to our" +"sun. We can reduce that number further by estimating the fraction of +them that have planets, the fraction of them that have earthlike planets, +etc. After making a number of reasonable assumptions, we come up with +an estimate of ten thousand advanced civilizations in our own Milky +Way galaxy. (Carl Sagan, with a different set of estimates, came up with +the number one million.)" +"Since then, scientists have been able to make much better estimates of +the number of advanced civilizations in our galaxy. For example, we +know there are more planets orbiting stars than Drake originally +expected, and more earthlike planets as well. But we still face a problem. +Even if we know how many earthlike twins there are in space, we still +don’t know how many of them support intelligent life. Even on Earth, it +took 4.5 billion years before intelligent beings (us) finally arose from the +swamp. For about 3.5 billion years, life-forms have existed on Earth, but +only in the last one hundred thousand years or so have intelligent beings + + like us emerged. So even on an earthlike planet like Earth itself, the rise +of truly intelligent life has been very difficult. + +WHY DON’T THEY VISIT US?" +"WHY DON’T THEY VISIT US? + +But then I asked Dr. Seth Shostak of SETI this killer question: If there are +so many stars in the galaxy, and so many alien civilizations, then why +don’t they visit us? This is the Fermi paradox, named for Enrico Fermi, +the Nobel laureate who helped build the atomic bomb and unlocked the +secrets of the nucleus of the atom. + +Many theories have been proposed. For one, the distance between +stars might be too great. It would take about seventy thousand years for +our most powerful chemical rockets to reach the stars nearest to Earth. +Perhaps a civilization thousands to millions of years more advanced than +ours may solve this problem, but there’s another possibility. Maybe they +annihilated themselves in a nuclear war. As John F. Kennedy once said, +“I am sorry to say there is too much point to the wisecrack that life is +extinct on other planets because their scientists were more advanced +than ours.”" +"But perhaps the most logical reason is this: Imagine walking down a +country road and encountering an ant hill. Do we go down to the ants + +and say, “I bring you trinkets. I bring you beads. I give you nuclear +energy. I will create an ant paradise for you. Take me to your leader”? + +Probably not. + +Now imagine that workers are building an eight-lane superhighway +next to the anthill. Would the ants know what frequency the workers are +talking on? Would they even know what an eight-lane superhighway +was? In the same fashion, any intelligent civilization that can reach +Earth from the stars would be thousands of years to millions of years +ahead of us, and we may have nothing to offer them. In other words, we +are arrogant to believe that aliens will travel trillions upon trillions of +miles just to see us. + +More than likely, we are not on their radar screen. Ironically, the +galaxy could be teaming with intelligent life-forms and we are so +primitive that we are oblivious of them. + +FIRST CONTACT" +"FIRST CONTACT + + But assume for the moment that the time will come, perhaps sooner +rather than later, when we make contact with an alien civilization. This +moment could be a turning point in the history of humanity. So the next +questions are: What do they want, and what will their consciousness be +like? + +In the movies and in science-fiction novels, the aliens often want to +eat us, conquer us, mate with us, enslave us, or strip our planet of +valuable resources. But all this is highly improbable. + +Our first contact with an alien civilization will probably not begin +with a flying saucer landing on the White House lawn. More likely, it +will happen when some teenager, running a screen saver from the +SETI@home project, announces that his or her PC has decoded signals +from the Arecibo radio telescope in Puerto Rico. Or perhaps when the +SETI project at Hat Creek detects a message that indicates intelligence." +"Our first encounter will therefore be a one-way event. We will be able +to eavesdrop on intelligent messages, but a return message may take +decades or centuries to reach them. + +The conversations that we hear on the radio may give us valuable +insight into this alien civilization. But most of the message will likely be + +gossip, entertainment, music, etc., with little scientific content. + +Then I asked Dr. Shostak the next key question: Will you keep it a +secret once First Contact is made? After all, won’t it cause mass panic, +religious hysteria, chaos, and spontaneous evacuations? I was a bit +surprised when he said no. They would give all the data to the +governments of the world and to the people. + +The next questions are: What will they be like? How do they think? + +To understand alien consciousness, perhaps it is instructive to analyze +another consciousness that is quite alien to us, the consciousness of +animals. We live with them, yet we are totally ignorant of what goes on +in their minds." +"Understanding animal consciousness, in turn, may help us understand +alien consciousness. + +ANIMAL CONSCIOUSNESS + + Do animals think? And if so, what do they think about? This question +has perplexed the greatest minds in history for thousands of years. The +Greek writers and historians Plutarch and Pliny both wrote about a +famous question that remains unsolved even today. Over the centuries, +many solutions have been given by the giants of philosophy. + +A dog is traveling down a road, looking for its master, when it +encounters a fork that branches in three directions. The dog first takes +the left path, sniffs around, and then returns, knowing that his master +has not taken that road. Then it takes the right path, sniffs, and realizes +that his master has not taken this road either. But this time, the dog +triumphantly takes the middle road, without sniffing." +"What was going on in the dog’s mind? Some of the greatest +philosophers have tackled this question, to no avail. The French +philosopher and essayist Michel de Montaigne wrote that the dog +obviously concluded that the only possible solution was to take the +middle road, a conclusion showing that dogs are capable of abstract +thought. + +But St. Thomas Aquinas, arguing in the thirteenth century, said the +opposite—that the appearance of abstract thought is not the same thing +as genuine thinking. We can be fooled by superficial appearances of + +intelligence, he claimed. + +Centuries later, there was also a famous exchange between John Locke +and George Berkeley about animal consciousness. “Beasts abstract not,” +proclaimed Locke flatly. To which Bishop Berkeley responded, “If the +fact that brutes abstract not be made the distinguishing property of that +sort of animal, I fear a great many of those that pass for man must be +reckoned into their number.”" +"Philosophers down the ages have tried to analyze this question in the +same manner: by imposing human consciousness on the dog. This is the +mistake of anthropomorphism, or assuming that animals think and +behave like us. But perhaps the real solution might be to look at this +question from the dog’s point of view, which could be quite alien. + +In Chapter 2, I gave a definition of consciousness in which animals +were part of a continuum of consciousness. Animals can differ from us in +the parameters they use to create a model of the world. Dr. David +Eagleman says that psychologists call this “umwelt,” or the reality +perceived by other animals. He notes, “In the blind and deaf world of the +tick, the important signals are temperature and the odor of butyric acid. +For the black ghost knifefish, it’s electrical fields. For the echo locating +bat, air-compressed waves. Each organism inhabits its own umwelt, + + which it presumably assumes to be the entire objective reality ‘out +there.’ ”" +"which it presumably assumes to be the entire objective reality ‘out +there.’ ” + +Consider the brain of a dog, which is constantly living in a swirl of +odors, by which it hunts for food or locates a mate. From these smells, +the dog then constructs a mental map of what exists in its surroundings. +This map of smells is totally different from the one we get from our eyes +and conveys an entirely different set of information. (Recall from +Chapter 1 that Dr. Penfield constructed a map of the cerebral cortex, +showing the distorted self-image of the body. Now imagine a Penfield +diagram of a dog’s brain. Most of it would be devoted to its nose, not its +fingers. Animals would have a totally different Penfield diagram. Aliens +in space would likely have an even stranger Penfield diagram.)" +"Unfortunately, we tend to assign human consciousness to animals, +even though animals may have a totally different world outlook. For +example, when a dog faithfully follows its master’s orders, we +subconsciously assume that the dog is man’s best friend because he likes +us and respects us. But since the dog is descended from Cards lupus (the + +gray wolf), which hunts in packs with a rigid pecking order, more than +likely the dog sees you as some sort of alpha male, or the leader of the +pack. You are, in some sense, the Top Dog. (This is probably one reason +why puppies are much easier to train than older dogs; it is likely easier +to imprint one’s presence on a puppy’s brain, while more mature dogs +realize that humans are not part of their pack.)" +"Also, when a cat enters a new room and urinates all over the carpet, +we assume that the cat is angry or nervous, and we try to find out the +reason why the cat is upset. But perhaps the cat is simply marking its +territory with the smell of its urine to ward off other cats. So the cat is +not upset at all; it’s simply warning other cats to stay out of the house, +because the house belongs to it. + +And if the cat purrs and rubs itself against your legs, we assume that it +is grateful to you for taking care of it, that this is a sign of warmth and +affection. More than likely, the cat is rubbing its hormone onto you to +claim ownership of its possession (i.e., you), to ward off other cats. In +the cat’s viewpoint, you are a servant of some sort, trained to give it +food several times a day, and rubbing its scent on you warns other cats +to stay away from this servant." +"As the sixteenth-century philosopher Michel de Montaigne once wrote, +“When I play with my cat, how do I know that she is not playing with +me rather than I with her?” + +And if the cat then stalks off to be alone, it is not necessarily a sign of +anger or aloofness. The cat is descended from the wildcat, which is a + + solitary hunter, unlike the dog. There is no alpha male to slobber over, +as in the case of the dog. The proliferation of various “animal whisperer” +programs on TV is probably a sign of the problems we encounter when +we force human consciousness and intentions onto animals." +"A bat would also have a much different consciousness, which would +be dominated by sounds. Almost blind, the bat requires constant +feedback from tiny squeaks it makes, which allow it to locate insects, +obstacles, and other bats via sonar. The Penfield map of its brain would +be quite alien to us, with a huge portion devoted to its ears. Similarly, +dolphins have a different consciousness than humans, which is also +based on sonar. Because dolphins have a smaller frontal cortex, it was +once thought that they were not so intelligent, but the dolphin +compensates for this by having a larger brain mass. If you unfold the + +neocortex of the dolphin brain, it would cover six magazine pages, while +if you unfold the neocortex of a human, it would measure only four +magazine pages. Dolphins also have very well-developed parietal and +temporal cortices to analyze sonar signals in the water and are one of +the few animals that can recognize themselves in a mirror, probably +because of this fact." +"In addition, the dolphin brain is actually structured differently from +humans’ because dolphin and human lineages diverged about ninety-five +million years ago. Dolphins have no need for a nose, so their olfactory +bulb disappears soon after birth. But thirty million years ago, their +auditory cortex exploded in size because dolphins learned to use +echolocation, or sonar, to find food. Like bats’, their world must be one +of whirling echoes and vibrations. Compared to humans, dolphins have +an extra lobe in their limbic system, called the “paralimbic” region, +which probably helps them forge strong social relations." +"Meanwhile, dolphins also have a language that is intelligent. I once +swam in a pool of dolphins for a TV special for the Science Channel. I +put sonar sensors in the pool that could pick up the clicks and whistles +used by dolphins to talk to one another. These signals were recorded and +then analyzed by computer. There is a simple way to discern if there is +an intelligence lurking among this random set of squeals and chirps. In +the English language, for example, the letter e is the most commonly +used letter of the alphabet. In fact, we can create a list of all the letters +of the alphabet and how frequently they occur. No matter what book in +English we analyze by computer, it will roughly obey the same list of +commonly found letters of the alphabet. + +Similarly, this computer program can be used to analyze the dolphins’ +language. Sure enough, we find a similar pattern indicating intelligence. +However, as we go to other mammals, the pattern begins to break down," +"and it finally collapses completely as we approach lower animals with +small brain sizes. Then the signals become nearly random. + +INTELLIGENT BEES? + +To get a sense of what alien consciousness might be like, consider the +strategies adopted by nature to reproduce life on Earth. There are two + +basic reproductive strategies nature has taken, with profound +implications for evolution and consciousness. + +The first, the strategy used by mammals, is to produce a small number +of young offspring and then carefully nurse each one to maturity. This is +a risky strategy, because only a few progeny are produced in each +generation, so it assumes that nurturing will even out the odds. This +means that every life is cherished and carefully nurtured for a length of +time." +"But there is another, much older strategy that is used by much of the +plant and animal kingdom, including insects, reptiles, and most other +life-forms on Earth. This involves creating a large number of eggs or +seeds and then letting them fend for themselves. Without nurturing, +most of the offspring never survive, so only a few hardy individuals will +make it into the next generation. This means that the energy invested in +each generation by the parents is nil, and reproduction relies on the law +of averages to propagate the species." +"These two strategies produce startlingly different attitudes toward life +and intelligence. The first strategy treasures each and every individual. +Love, nurturing, affection, and attachment are at a premium in this +group. This reproductive strategy can work only if the parents invest a +considerable amount of precious energy to preserve their young. The +second strategy, however, does not treasure the individual at all, but +rather emphasizes the survival of the species or group as a whole. To +them, individuality means nothing." +"Furthermore, reproductive strategy has profound implications for the +evolution of intelligence. When two ants meet each other, for example, +they exchange a limited amount of information using chemical scents +and gestures. Although the information shared by two ants is minimal, +with this information they are capable of creating elaborate tunnels and +chambers necessary to build an anthill. Similarly, although honeybees +communicate with one another by performing a dance, they can +collectively create complex honeycombs and locate distant flower beds. +So their intelligence arises not so much from the individual, but from the + + holistic interaction of the entire colony and from their genes. + +So consider an intelligent extraterrestrial civilization based on the +second strategy, such as an intelligent race of honeybees. In this society, +the worker bees that fly out each day in search of pollen are expendable." +"Worker bees do not reproduce at all, but instead live for one purpose, to +serve the hive and the queen, for which they willingly sacrifice +themselves. The bonds that link mammals together mean nothing to +them. + +Hypothetically, this might affect the development of their space +program. Since we treasure the life of every astronaut, considerable +resources are devoted to bringing them back alive. Much of the cost of +space travel goes into life support so the astronauts can make the return +voyage home and reenter the atmosphere. But for a civilization of +intelligent honeybees, each worker’s life may not be worth that much, so +their space program would cost considerably less. Their workers would +not have to come back. Every voyage might be a one-way trip, and that +would represent significant savings." +"Now imagine if we were to encounter an alien from space that was +actually similar to a honeybee worker. Normally, if we encounter a +honeybee in the forest, chances are it will completely ignore us, unless +we threaten it or the hive. It’s as if we did not exist. Similarly, this +worker would most likely not have the slightest interest in making +contact with us or sharing its knowledge. It would go on with its primary +mission and ignore us. Moreover, the values that we cherish would mean +little to it. + +Back in the 1970s, there were two medallions put aboard the Pioneer +10 and 11 probes, containing crucial information about our world and +society. The medallions exalted the diversity and richness of life on +Earth. Scientists back then assumed that alien civilizations in space +would be like us, curious and interested in making contact. But if such +an alien worker bee were to find our medallion, chances are that it +would mean nothing to it." +"Furthermore, each worker need not be very intelligent. They need to +be only intelligent enough to serve the interest of the hive. So if we were +to send a message to a planet of intelligent bees, chances are that they +would show little interest in sending a message back. + +Even if contact could be made with such a civilization, it might be +difficult communicating with them. For example, when we communicate +with one another, we break ideas down into sentences, with a subject- +verb structure, in order to build a narrative, often a personal story. Most + + of our sentences have the following structure: “I did this” or “They did + +that.” In fact, most of our literature and conversations use storytelling, +often involving experiences and adventures that we or our role models +have had. This presupposes that our personal experiences are the +dominant way to convey information." +"However, a civilization based on intelligent honeybees may not have +the least interest in personal narratives and storytelling. Being highly +collective, their messages may not be personal, but matter-of-fact, +containing vital information necessary for the hive rather than personal +trivia and gossip that might advance an individual’s social position. In +fact, they might find our storytelling language to be a bit repulsive, since +it puts the role of the individual before the needs of the collective. + +Also, worker bees would have a totally different sense of time. Since +worker bees are expendable, they might not have a long life span. They +might only take on projects that are short and well defined." +"However, humans live much longer, but we also have a tacit sense of +time; we take on projects and occupations that we can reasonably see to +the end within our lifetimes. We subconsciously pace our projects, our +relations with others, and our goals to accommodate a finite life span. In +other words, we live our lives in distinct phases: being single, married, +raising children, and eventually retiring. Often without being conscious +of it, we assume that we will live and eventually die within a finite time +frame." +"But imagine beings that can live for thousands of years, or are perhaps +immortal. Their priorities, their goals, and their ambitions would be +completely different. They could take on projects that would normally +require scores of human lifetimes. Interstellar travel is often dismissed as +pure science fiction because, as we have seen, the time it takes for a +conventional rocket to reach nearby stars is roughly seventy thousand +years. For us, this is prohibitively long. But for an alien life-form, that +time may be totally irrelevant. For example, they might be able to +hibernate, slow down their metabolism, or simply live for an indefinite +amount of time. + +WHAT DO THEY LOOK LIKE? + +Our first translations of these alien messages will probably give us some" +"Our first translations of these alien messages will probably give us some + + insight into the aliens’ culture and way of life. For example, it is likely +that the aliens will have evolved from predators and hence still share +some of their characteristics. (In general, predators on Earth are smarter +than prey. Hunters like tigers, lions, cats, and dogs use their cunning to +stalk, ambush, and hide, all of which require intelligence. All these +predators have eyes on the front of the face, for stereo vision as they +focus their attention. Prey, which have eyes to the sides of the face to +spot a predator, have only to run. That is why we say “sly as a fox” and +“dumb bunny.”) The alien life-forms may have outgrown many of the +predator instincts of their distant ancestors, but it is likely that they will +still have some of a predator’s consciousness (i.e., territoriality, +expansion, and violence when necessary)." +"If we examine the human race, we see that there were at least three +basic ingredients that set the stage for our becoming intelligent: + +1 . the opposable thumb, which gives us the ability to manipulate and + +reshape our environment via tools + +2. stereo eyes or the 3-D eyes of a hunter + +3. language, which allows us to accumulate knowledge, culture, and + +wisdom across generations + +When we compare these three ingredients with the traits found in the +animal kingdom, we see that very few animals meet these criteria for +intelligence. Cats and dogs, for example, do not have grasping ability or +a complex language. Octopi have sophisticated tentacles, but they don’t +see well and don’t have a complex language." +"There may be variations of these three criteria. Instead of an +opposable thumb, an alien might have claws or tentacles. (The only +prerequisite is that they should be able to manipulate their environment +with tools created by these appendages.) Instead of having two eyes, +they may have many more, like insects. Or they may have sensors that +detect sound or UV light rather than visible light. More than likely, they +will have the stereo eyes of a hunter, because predators generally have a +higher level of intelligence than prey. Also, instead of a language based +on sounds, they may communicate via different forms of vibrations. (The +only requirement is that they exchange information among themselves to + +create a culture spanning many generations.) + +But beyond these three criteria, anything goes." +"Next, the aliens may have a consciousness colored by their +environment. Astronomers now realize that the most plentiful habitat for +life in the universe may not be earthlike planets, where they can bask in +the warm sunlight of the mother star, but on icy-cold satellites orbiting +Jupiter-size planets billions of miles from the star. It is widely believed +that Europa, an ice-covered moon of Jupiter, has a liquid ocean beneath +the icy surface, heated by tidal forces. Because Europa tumbles as it +orbits Jupiter, it is squeezed in different directions by the huge +gravitational pull of Jupiter, which causes friction deep inside the moon. +This generates heat, forming volcanoes and ocean vents that melt the ice +and create liquid oceans. It is estimated that the oceans of Europa are +quite deep, and that their volume may be many times the volume of the +oceans of Earth. Since 50 percent of all stars in the heavens may have +Jupiter-size planets (a hundred times more plentiful than earthlike" +"Jupiter-size planets (a hundred times more plentiful than earthlike +planets), the most plentiful form of life may be on the icy moons of gas +giants like Jupiter." +"Therefore, when we encounter our first alien civilization in space, +more than likely it will have an aquatic origin. (Also, it is likely that +they will have migrated from the ocean and learned to live on the icy +surface of their moon away from the water, for several reasons. First, +any species that lives perpetually under the ice will have a quite limited +view of the universe. They will never develop astronomy or a space +program if they think that the universe is just the ocean underneath the +ice cover. Second, because water short-circuits electrical components, +they will never develop radio or TV if they stay underwater. If this +civilization is to advance, it must master electronics, which cannot exist +in the oceans. So, most likely, these aliens will have learned to leave the +oceans and survive on the land, as we did.)" +"But what happens if this life-form evolves to create a space-faring +civilization, capable of reaching Earth? Will they still be biological +organisms like us, or will they be post-biological? + +THE POST-BIOLOGICAL ERA + +One person who has spent considerable time thinking about these +questions is my colleague Dr. Paul Davies of Arizona State University, +near Phoenix. When I interviewed him, he told me that we have to +expand our own horizon to contemplate what a civilization that is +thousands or more years ahead of us may look like. + +Given the dangers of space travel, he believes that such beings will +have abandoned their biological form, much like the bodiless minds we +considered in the previous chapter. He writes, “My conclusion is a +startling one. I think it very likely—in fact inevitable—that biological" +"intelligence is only a transitory phenomenon, a fleeting phase in the +evolution of intelligence in the universe. If we ever encounter +extraterrestrial intelligence, I believe it is overwhelmingly likely to be +post-biological in nature, a conclusion that has obvious and far-reaching +ramifications for SETI.” + +In fact, if the aliens are thousands of years ahead of us, chances are +that they have abandoned their biological bodies eons ago to create the +most efficient computational body: a planet whose entire surface is +completely covered with computers. Dr. Davies says, “It isn’t hard to +envision the entire surface of a planet being covered with a single +integrated processing system.... Ray Bradbury has coined the term +‘Matrioshka brains’ for these awesome entities.”" +"So to Dr. Davies, alien consciousness may lose the concept of “self” +and be absorbed into the collective World Wide Web of Minds, which +blankets the entire surface of the planet. Dr. Davies adds, “A powerful +computer network with no sense of self would have an enormous +advantage over human intelligence because it could redesign ‘itself,’ +fearlessly make changes, merge with whole systems, and grow. ‘Feeling +personal’ about it would be a distinct impediment to progress.” + +So in the name of efficiency and increased computational ability, he +envisions members of this advanced civilization giving up their identity +and being absorbed into a collective consciousness. + +Dr. Davies acknowledges that critics of his idea may find this concept +rather repulsive. It appears as if this alien species is sacrificing +individuality and creativity to the greater good of the collective or the +hive. This is not inevitable, he cautions, but it is the most efficient +option for civilization." +"Dr. Davies also has a conjecture that he admits is rather depressing. + +When I asked him why these civilizations don’t visit us, he gave me a +strange answer. He said that any civilization that advanced would also +have developed virtual realities far more interesting and challenging +than reality. The virtual reality of today would be a children’s toy +compared to the virtual reality of a civilization thousands of years more +advanced than us. + +This means that perhaps their finest minds might have decided to play +out imaginary lives in different virtual worlds. It’s a discouraging +thought, he admitted, but certainly a possibility. In fact, it might even be +a warning for us as we perfect virtual reality. + + WHAT DO THEY WANT?" +"WHAT DO THEY WANT? + +In the movie The Matrix, the machines take over and put humans into +pods, where they exploit us as batteries to energize themselves. That is +why they keep us alive. But since a single electrical plant produces more +power than the bodies of millions of humans, any alien looking for an +energy source would quickly see there is no need for human batteries. +(This seems to be lost on the machine overlords in the Matrix, but +hopefully aliens would see reason.)" +"Another possibility is that they might want to eat us. This was +explored in an episode of The Twilight Zone, in which aliens land on +Earth and promise us the benefits of their advanced technology. They +even ask for volunteers to visit their beautiful home planet. The aliens +accidentally leave behind a book, called To Serve Man, which scientists +anxiously try to decipher in order to discover what wonders the aliens +will share with us. Instead, the scientists find out that the book is +actually a cookbook. (But since we will be made of entirely different +DNA and proteins from theirs, we could be difficult for their digestive +tracts to process.)" +"Another possibility is that the aliens will want to strip Earth of +resources and valuable minerals. There may be some truth to this +argument, but if the aliens are advanced enough to travel effortlessly +from the stars, then there are plenty of uninhabited planets to plunder +for resources, without having to worry about restive natives. From their +point of view, it would be a waste of time to try to colonize an inhabited + +planet when there are easy alternatives." +"planet when there are easy alternatives. + +So if the aliens do not want to enslave us or plunder our resources, +then what danger do they pose? Think of deer in a forest. Whom should +they fear the most—the ferocious hunter armed with a shotgun, or the +mild-mannered developer armed with a blueprint? Although the hunter +may scare the deer, only a few deer are threatened by him. More +dangerous to the deer is the developer, because the deer are not even on +his radar screen. The developer may not even think about the deer at all, +concentrating instead on developing the forest into usable property. In +view of this, what would an invasion actually look like?" +"In Hollywood movies, there is one glaring flaw: the aliens are only a +century or so ahead of us, so we can usually devise a secret weapon or +exploit a simple weakness in their armor to fight them off, as in Earth vs. +the Flying Saucers. But as SETI director Dr. Seth Shostak once told me, a +battle with an advanced alien civilization will be like a battle between +Bambi and Godzilla. + + In reality, the aliens might be millennia to millions of years ahead of +us in their weaponry. So, for the most part, there will be little we can do +to defend ourselves. But perhaps we can learn from the barbarians who +defeated the greatest military empire of its time, the Roman Empire. + +The Romans were masters of engineering, able to create weapons that +could flatten barbarian villages and roads to supply distant military +outposts of a vast empire. The barbarians, who were barely emerging +from a nomadic existence, had little chance when encountering the +juggernaut of the Roman Imperial Army." +"But history records that as the empire expanded, it was spread too +thin, with too many battles to fight, too many treaties bogging it down, +and not enough of an economy to support all this, especially with a +gradual decline in population. Moreover, the empire, always short on +recruits, had to enlist young barbarian soldiers and promote them to +leadership positions. Inevitably, the superior technology of the empire +began to filter down to the barbarians as well. In time, the barbarians +began to master the very military technologies that at first had +conquered them. + +Toward the end, the empire, weakened by internal palace intrigues, +severe crop shortages, civil wars, and an overstretched army, faced +barbarians who were able to fight the Roman Imperial Army to a + +standstill. The sacking of Rome in A.D. 410 and 455 paved the way for +the empire’s ultimate fall in A.D. 476." +"In the same way, it is likely that earthlings will initially offer no real +threat to an alien invasion, but over time earthlings could learn the weak +points of the alien army, its power supplies, its command centers, and +most of all its weaponry. In order to control the human population, the +aliens will have to recruit collaborators and promote them. This will +result in a diffusion of their technology to the humans. + +Then a ragtag army of earthlings might be able to mount a +counterattack. In Eastern military strategy, like the classic teachings of +Sun Tzu in The Art of War, there is a way to defeat even a superior army. +You first allow it to enter your territory. Once it has entered unfamiliar +land and its ranks are diffused, you can counterattack where they are +weakest." +"Another technique is to use the enemy’s strength against it. In judo, +the principal strategy is to turn the momentum of the attacker to your +advantage. You let the enemy attack, and then trip them or throw them +off guard, exploiting the enemy’s own mass and energy. The bigger they + + are, the harder they fall. In the same way, perhaps the only way to fight +a superior alien army is to allow it to invade your territory, learn its +weaponry and military secrets, and turn those very weapons and secrets +against it. + +So a superior alien army cannot be defeated head-on. But it will +withdraw if it cannot win and the cost of a stalemate is too high. Success +means depriving the enemy of a victory." +"But more than likely, I believe the aliens will be benevolent and, for +the most part, ignore us. We simply have nothing to offer them. If they +visit us, then it will be mainly out of curiosity or for reconnaissance. +(Since curiosity was an essential feature in our becoming intelligent, it is +likely that any alien species will be curious, and hence want to analyze +us, but not necessarily to make contact.) + +MEETING AN ALIEN ASTRONAUT + +Unlike in the movies, we will probably not meet the flesh-and-blood +alien creatures themselves. It would simply be too dangerous and + +unnecessary. In the same way that we sent the Mars Rover to explore, +aliens will more than likely send organic/mechanical surrogates or +avatars instead, which can better handle the stresses of interstellar +travel. In this way, the “aliens” we meet on the White House lawn may +look nothing like their masters back on the home planet. Instead, the +masters will project their consciousness into space through proxies." +"More than likely, though, they will send a robotic probe to our moon, +which is geologically stable, with no erosion. These probes are self- +replicating; that is, they will create a factory and manufacture, say, a +thousand copies of themselves. (These are called von Neumann probes, +after mathematician John von Neumann, who laid the foundation for +digital computers. Von Neumann was the first mathematician to +seriously consider the problem of machines that could reproduce +themselves.) These second-generation probes are then launched to other +star systems, where each one in turn creates a thousand more third- +generation probes, making a total of a million. Then these probes fan out +and create more factories, making a billion probes. Starting with just one +probe, we have one thousand, then a million, then a billion. Within five +generations, we have a quadrillion probes. Soon we have a gigantic +sphere, expanding at near light speed, containing trillions upon trillions" +"sphere, expanding at near light speed, containing trillions upon trillions +of probes, colonizing the entire galaxy within a few hundred thousand +years." +"Dr. Davies takes this idea of self-replicating von Neumann probes so +seriously that he has actually applied for funding to search the surface of +the moon for evidence of a previous alien visitation. He wishes to scan +the moon for radio emissions or radiation anomalies that would indicate +evidence of an alien visitation, perhaps millions of years ago. He wrote a +paper with Dr. Robert Wagner in the scientific journal Acta Astronautica +calling for a close examination of the photos from the Lunar +Reconnaissance Orbiter down to a resolution of about 1.5 feet." +"They wrote, “Although there is only a tiny probability that alien +technology would have left traces on the moon in the form of an artifact +or surface modification of lunar features, this location has the virtue of +being close,” and also traces of an alien technology would remain +preserved over long periods of time. Since there is no erosion on the +moon, treadmarks left by aliens would still be visible (in the same way +that footprints left by our astronauts in the 1970s could, in principle, last + +for billions of years). + +One problem is that the von Neumann probe might be very small. +Nanoprobes use molecular machines and MEMs, and hence it might be +only as big as a bread box, he said to me, or even smaller. (In fact, if +such a probe landed on Earth in someone’s backyard, the owner might +not even notice.)" +"This method, however, represents the most efficient way of colonizing +the galaxy, using the exponential growth of self-replicating von +Neumann probes. (This is also the way in which a virus infects our body. +Starting with a handful of viruses, they land on our cells, hijack the +reproductive machinery, and convert our cells into factories to create +more viruses. Within two weeks, a single virus can infect trillions of +cells, and we eventually sneeze.)" +"If this scenario is correct, it means that our own moon is the most +likely place for an alien visitation. This is also the basis of the movie +2001: A Space Odyssey, which even today represents the most plausible +encounter with an extraterrestrial civilization. In the movie, a probe was +placed on our moon millions of years ago, mainly to observe the +evolution of life on Earth. At times, it interferes in our evolution and +gives us an added boost. This information is then sent to Jupiter, which +is a relay station, before heading to the home planet of this ancient alien +civilization. + +From the point of view of this advanced civilization, which can +simultaneously scan billions of star systems, we can see that they have a +considerable choice in what planetary systems to colonize. Given the +sheer enormity of the galaxy, they can collect data and then best choose + + which planets or moons would yield the best resources. From their +perspective, they might not find Earth very appealing." +"The empires of the future will be empires of the mind. + +—WINSTON CHURCHILL + +If we continue to develop our technology without wisdom +prudence, our servant may prove to be our executioner. + +—GENERAL OMAR BRADLEY + +15 CONCLUDING REMARKS + +In 2000, a raging controversy erupted in the scientific community. +One of the founders of Sun Computers, Bill Joy, wrote an inflammatory +article denouncing the mortal threat we face from advanced technology. +In an article in Wired magazine with the provocative title “The Future +Does Not Need Us,” he wrote, “Our most powerful 21st century +technologies—robotics, genetic engineering, and nanotech—are +threatening to make humans an endangered species.” That incendiary +article questioned the very morality of hundreds of dedicated scientists +toiling in their labs on the cutting edge of science. He challenged the +very core of their research, stating that the benefits of these technologies +were vastly overshadowed by the enormous threats they posed to +humanity." +"He described a macabre dystopia in which all our technologies +conspire to destroy civilization. Three of our key creations will +eventually turn on us, he warned: + +• One day, bioengineered germs may escape from the laboratory and +wreak havoc on the world. Since you cannot recapture these life- +forms, they might proliferate wildly and unleash a fatal plague on +the planet worse than those of the Middle Ages. Biotechnology may +even alter human evolution, creating “several separate and unequal +species ... that would threaten the notion of equality that is the very +cornerstone of our democracy.” + +• One day, nanobots may go berserk and spew out unlimited +quantities of “gray goo,” which will blanket Earth, smothering all +life. Since these nanobots “digest” ordinary matter and create new +forms of matter, malfunctioning nanobots could run amok and" +"digest much of Earth. “Gray goo would surely be a depressing +ending to our human adventure on Earth, far worse than mere fire +or ice, and one that could stem from a simple laboratory accident. + +Oops,” he wrote. + +• One day, the robots will take over and replace humanity. They will +become so intelligent that they will simply push humanity aside. We +will be left as an evolutionary footnote. “The robots would in no +sense be our children.... On this path our humanity may well be +lost,” he wrote." +"Joy claimed that the dangers unleashed by these three technologies +dwarfed the dangers posed by the atomic bomb in the 1940s. Back then, +Einstein warned of the power of nuclear technology to destroy +civilization: “It has become appallingly obvious that our technology has +exceeded our humanity.” But the atomic bomb was built by a huge +government program that could be tightly regulated, while these +technologies are being developed by private companies that are lightly +regulated, if at all, Joy pointed out. + +Sure, he conceded, these technologies may alleviate some suffering in +the short term. But in the long term, the benefits are overwhelmed by +the fact that they may unleash a scientific Armageddon that may doom +the human race." +"Joy even accused scientists of being selfish and naive as they try to +create a better society. He wrote, “A traditional utopia is a good society +and a good life. A good life involves other people. This techno utopia is +all about ‘I don’t get diseases; I don’t die; I get to have better eyesight +and be smarter’ and all this. If you described this to Socrates or Plato, +they would laugh at you.” + +He concluded by stating, “I think it is no exaggeration to say we are +on the cusp of the further perfection of extreme evil, an evil whose +possibility spreads well beyond that which weapons of mass destruction +bequeathed to the nation-states....” + +The conclusion to all this? “Something like extinction,” he warned. + +As expected, the article sparked a firestorm of controversy." +"As expected, the article sparked a firestorm of controversy. + +That article was written over a decade ago. In terms of high +technology, that is a lifetime. It is now possible to view certain of its +predictions with some hindsight. Looking back at the article and putting +his warnings into perspective, we can easily see that Bill Joy exaggerated +many of the threats coming from these technologies, but he also spurred + + scientists to face up to the ethical, moral, and societal consequences of + +their work, which is always a good thing. + +And his article opened up a discussion about who we are. In +unraveling the molecular, genetic, and neural secrets of the brain, +haven’t we in some sense dehumanized humanity, reducing it to a +bucket of atoms and neurons? If we completely map every neuron of the +brain and trace every neural pathway, doesn’t that remove the mystery +and magic of who we are? + +A RESPONSE TO BILL JOY" +"A RESPONSE TO BILL JOY + +In retrospect, the threats from robotics and nanotechnology are more +distant than Bill Joy thought, and I would argue that with enough +warning, we can take a variety of countermeasures, such as banning +certain avenues of research if they lead to uncontrollable robots, placing +chips in them to shut them off if they become dangerous, and creating +fail-safe devices to immobilize all of them in an emergency. + +More immediate is the threat from biotechnology, where there is the +realistic danger of biogerms that might escape the laboratory. In fact, +Ray Kurzweil and Bill Joy jointly wrote an article criticizing the +publication of the complete genome of the 1918 Spanish flu virus, one of +the most lethal germs in modern history, which killed more people than +World War I. Scientists were able to reassemble the long-dead virus by +examining the corpses and blood of its victims and sequencing its genes, +and then they published it on the web." +"Safeguards already exist against the release of such a dangerous virus, +but steps must be taken to further strengthen them and add new layers +of security. In particular, if a new virus suddenly erupts in some distant +place on Earth, scientists must strengthen rapid-response teams that can +isolate the virus in the wild, sequence its genes, and then quickly +prepare a vaccine to prevent its spread. + +IMPLICATIONS FOR THE FUTURE OF THE MIND + +This debate also has a direct impact on the future of the mind. At +present, neuroscience is still rather primitive. Scientists can read and +videotape simple thoughts from the living brain, record a few memories, + + connect the brain to mechanical arms, enable locked-in patients to +control machines around them, silence specific regions of the brain via +magnetism, and identify the regions of the brain that malfunction in +mental illness." +"In the coming decades, however, the power of neuroscience may +become explosive. Current research is on the threshold of new scientific +discoveries that will likely leave us breathless. One day, we might +routinely control objects around us with the power of the mind, +download memories, cure mental illness, enhance our intelligence, +understand the brain neuron by neuron, create backup copies of the +brain, and communicate with one another telepathically. The world of +the future will be the world of the mind." +"Bill Joy did not dispute the potential of this technology to relieve +human suffering and pain. But what made him look on it with horror +was the prospect of enhanced individuals who might cause the human +species to split apart. In the article, he painted a dismal dystopia in +which only a tiny elite have their intelligence and mental processes +enhanced, while the masses of people live in ignorance and poverty. He +worried that the human race would fission in two, or perhaps cease to be +human at all. + +But as we have pointed out, almost all technologies when they are first +introduced are expensive and hence exclusively for the well-off. Because +of mass production, the falling cost of computers, competition, and +cheaper shipping, technologies inevitably filter down to the poor as well. +This was also the trajectory taken by phonographs, radio, TV, PCs, +laptops, and cell phones." +"Far from creating a world of haves and have-nots, science has been the +engine of prosperity. Of all the tools that humanity has harnessed since +the dawn of time, by far the most powerful and productive has been +science. The incredible wealth we see all around us is directly due to +science. To appreciate how technology reduces, rather than accentuates, +societal fault lines, consider the lives of our ancestors around 1900. Life +expectancy in the United States back then was forty-nine years. Many +children died in infancy. Communicating with a neighbor involved +yelling out the window. The mail was delivered by horse, if it came at +all. Medicine was largely snake oil. The only treatments that actually +worked were amputations (without anesthetics) and morphine to deaden + +the pain. Food rotted within days. Plumbing was nonexistent. Disease +was a constant threat. And the economy could support only a handful of +the rich and a tiny middle class." +"Technology has changed everything. We no longer have to hunt for +our food; we simply go to the supermarket. We no longer have to carry +back-breaking supplies but instead simply get into our cars. (In fact, the +main threat we face from technology, one that has killed millions of +people, is not murderous robots or mad nanobots run amok—it’s our +indulgent lifestyle, which has created near-epidemic levels of diabetes, +obesity, heart disease, cancer, etc. And this problem is self-inflicted.) + +We also see this on the global level. In the last few decades the world +has witnessed hundreds of millions of people being lifted out of grinding +poverty for the first time in history. If we view the bigger picture, we see +that a significant fraction of the human race has left the punishing +lifestyle of sustenance farming and entered the ranks of the middle class." +"It took several hundred years for Western nations to industrialize, yet +China and India are doing it within a few decades, all due to the spread +of high technology. With wireless technology and the Internet, these +nations can leapfrog past other, more developed nations that have +laboriously wired their cities. While the West struggles with an aging, +decaying urban infrastructure, developing nations are building entire +cities with sparkling, state-of-the-art technology." +"(When I was a graduate student getting my Ph.D., my counterparts in +China and India would have to wait several months to a year for +scientific journals to come in the mail. Plus, they had almost no direct +contact with scientists and engineers in the West, because few if any +could afford to travel here. This vastly impeded the flow of technology, +which moved at a glacial pace for these nations. Today, however, +scientists can read one another’s papers as soon as they are posted on the +Internet, and can electronically collaborate with other scientists around +the world. This has vastly accelerated the flow of information. And with +this technology comes progress and prosperity.)" +"Furthermore, it’s not clear that having some form of enhanced +intelligence will cause a catastrophic splitting of the human race, even if +many people are unable to afford this procedure. For the most part, +being able to solve complex mathematical equations or have perfect +recall does not guarantee a higher income, respect from your peers, or + +more popularity with the opposite sex, which are the incentives that +motivate most people. The Caveman Principle trumps having a brain +boost. + +As Dr. Michael Gazzaniga notes, “The idea that we are messin’ with +our innards is disturbing to many. And just what would we do with +expanded intelligence? Are we going to use it for solving problems, or +will it just allow us to have longer Christmas card lists ...?”" +"But as we discussed in Chapter 5, unemployed workers may benefit +from this technology, drastically reducing the time required to master +new technologies and skills. This might not only reduce the problems +associated with unemployment, it could also have an impact on the +world economy, making it more efficient and responsive to change. + +WISDOM AND DEMOCRATIC DEBATE + +In responding to Joy’s article, some critics pointed out that the debate is +not about a struggle between scientists and nature, as portrayed in the +article. The debate is actually between three parties: scientists, nature, +and society." +"Computer scientists Drs. John Brown and Paul Duguid responded to +the article by stating, “Technologies—such as gunpowder, the printing +press, the railroad, the telegraph, and the Internet—can change society +in profound ways. But on the other hand, social systems—in the form of +governments, the courts, formal and informal organizations, social +movements, professional networks, local communities, market +institutions, and so forth—shape, moderate, and redirect the raw power +of technologies.” + +The point is to analyze them in terms of society, and ultimately it is up +to us to adopt a new vision of the future that incorporates all the best +ideas. + +To me, the ultimate source of wisdom in this respect comes from +vigorous democratic debate. In the coming decades, the public will be +asked to vote on a number of crucial scientific issues. Technology cannot +be debated in a vacuum. + +PHILOSOPHICAL QUESTIONS" +"PHILOSOPHICAL QUESTIONS + +Lastly, some critics have claimed that the march of science has gone too +far in unveiling the secrets of the mind, an unveiling that has become +dehumanizing and degrading. Why bother to rejoice at discovering +something new, learning a new skill, or enjoying a leisurely vacation +when it can all be reduced to a few neurotransmitters activating a few +neural circuits? + +In other words, just as astronomy has reduced us to insignificant +pieces of cosmic dust floating in an uncaring universe, neuroscience has +reduced us to electrical signals circulating within neural circuits. But is +this really true?" +"We began our discussion by highlighting the two greatest mysteries in +all of science: the mind and the universe. Not only do they have a +common history and narrative, they also share a similar philosophy and +perhaps even destiny. Science, with all its power to peer into the heart of +black holes and land on distant planets, has given birth to two +overarching philosophies about the mind and the universe: the +Copernican Principle and the Anthropic Principle. Both are consistent +with everything known about science, but they are diametrical +opposites. + +The first great philosophy, the Copernican Principle, was born with +the discovery of the telescope more than four hundred years ago. It +states that there is no privileged position for humanity. Such a +deceptively simple idea has overthrown thousands of years of cherished +myths and entrenched philosophies." +"Ever since the biblical tale of Adam and Eve being exiled from the +Garden of Eden for biting into the Apple of Knowledge, there has been a +series of humiliating dethronements. First, the telescope of Galileo +clearly showed that Earth was not the center of the solar system—the +sun was. This picture was then overthrown when it was realized that the +solar system was just a speck in the Milky Way galaxy circulating about +thirty thousand light-years from the center. Then in the 1920s, Edwin +Hubble discovered there was a multitude of galaxies. The universe +suddenly got billions of times bigger. Now the Hubble Space Telescope +can reveal the presence of up to one hundred billion galaxies in the +visible universe. Our own Milky Way galaxy has been reduced to a +pinpoint in a much larger cosmic arena. + +More recent cosmological theories further downgrade the position of" +"More recent cosmological theories further downgrade the position of + +humanity in the universe. The inflationary universe theory states that +our visible universe, with its one hundred billion galaxies, is just a +pinprick on a much larger, inflated universe that is so big that most light +has not had time to reach us yet from distant regions. There are vast +reaches of space that we cannot see with our telescopes and will never +be able to visit because we cannot go faster than light. And if string +theory (my specialty) is correct, it means that even the entire universe +coexists with other universes in eleven-dimensional hyperspace. So even +three-dimensional space is not the final word. The true arena for +physical phenomena is the multiverse of universes, full of floating +bubble universes. + +The science-fiction writer Douglas Adams tried to summarize the sense +of being constantly overthrown by inventing the Total Perspective +Vortex in The Hitchhiker’s Guide to the Galaxy. It was designed to drive" +"any sane person insane. When you enter the chamber, all you see is a +gigantic map of the entire universe. And on the map there is a tiny, +almost invisible arrow that says, “You are here.” + +So on one hand, the Copernican Principle indicates that we are just +insignificant cosmic debris drifting aimlessly among the stars. But on the +other hand, all the latest cosmological data are consistent with yet +another theory, which gives us the opposite philosophy: the Anthropic +Principle. + +This theory states that the universe is compatible with life. Again, this +deceptively simple statement has profound implications. On one hand, it +is impossible to dispute that life exists in the universe. But it’s clear that +the forces of the universe must be calibrated to a remarkable degree to +make life possible. As physicist Freeman Dyson once said, “The universe +seemed to know that we were coming.”" +"For example, if the nuclear force were just a bit stronger, the sun +would have burned out billions of years ago, too soon to allow DNA to +get off the ground. If the nuclear force were a bit weaker, then the sun +would never have ignited to begin with, and we still would not be here. + +Likewise, if gravity were stronger, the universe would have collapsed +into a Big Crunch billions of years ago, and we would all be roasted to +death. If it were a bit weaker, then the universe would have expanded so +fast it would have reached the Big Freeze, so we would all have frozen to +death. + +This fine-tuning extends to every atom of the body. Physics says that +we are made of star dust, that the atoms we see all around us were +forged in the heat of a star. We are literally children of the stars." +"But the nuclear reactions that burned hydrogen to create the higher +elements of our body are very complex and could have been derailed at +any number of points. Then it would have been impossible to create the +higher elements of our bodies, and the atoms of DNA and life would not +exist. + +In other words, life is precious and a miracle. + +There are so many parameters that have to be fine-tuned that some +claim this is not a coincidence. The weak form of the Anthropic Principle +implies that the existence of life forces the physical parameters of the +universe to be defined in a very precise way. The strong form of the +Anthropic Principle goes even further, stating that God or some designer +had to create a universe “just right” to make life possible. + + PHILOSOPHY AND NEUROSCIENCE" +"PHILOSOPHY AND NEUROSCIENCE + +The debate between the Copernican Principle and the Anthropic +Principle also resonates in neuroscience. For example, some claim that +humans can be reduced to atoms, molecules, and neurons, and hence +there is no distinguished place for humanity in the universe. + +Dr. David Eagleman writes, “The you that all your friends know and +love cannot exist unless the transistors and screws of our brain are in +place. If you don’t believe this, step into any neurology ward in any +hospital. Damage to even small parts of the brain can lead to the loss of +shockingly specific abilities; the ability to name animals, or to hear +music, or to manage risky behavior, or to distinguish colors, or to +arbitrate simple decisions.” + +It seems that the brain cannot function without all its “transistors and +screws.” He concludes, “Our reality depends on what our biology is up +to.”" +"So on one hand, our place in the universe seems to be diminished if +we can be reduced, like robots, to (biological) nuts and bolts. We are just +wetware, running software called the mind, nothing more or less. Our +thoughts, desires, hopes, and aspirations can be reduced to electrical + +impulses circulating in some region of the prefrontal cortex. That is the +Copernican Principle applied to the mind. + +But the Anthropic Principle can also be applied to the mind, and we +then reach the opposite conclusion. It simply says that conditions of the +universe make consciousness possible, even though it is extraordinarily +difficult to create the mind out of random events. The great Victorian +biologist Thomas Huxley said, “How it is that anything so remarkable as +a state of consciousness comes about as a result of irritating nervous +tissue, is just as unaccountable as the appearance of the Djinn, when +Aladdin rubbed his lamp.”" +"Furthermore, most astronomers believe that although one day we may +find life on other planets, it will most likely be microbial life, which +ruled our oceans for billions of years. Instead of seeing great cities and +empires, we might only find oceans of drifting microorganisms. + +When I interviewed the late Harvard biologist Stephen Jay Gould +about this, he explained to me his thinking as follows. If we were to +somehow create a twin of Earth as it was 4.5 billion years ago, would it +turn out the same way 4.5 billion years later? Most likely not. There is a + + large probability that DNA and life would never have gotten off the +ground, and an even larger probability that intelligent life with +consciousness would never have risen from the swamp." +"Gould wrote, “Homo sapiens is one small twig [on the tree of life]. +... Yet our twig, for better or worse, has developed the most +extraordinary new quality in all the history of multicellular life since the +Cambrian explosion (500 million years ago). We have invented +consciousness with all its sequelae from Hamlet to Hiroshima.”" +"In fact, in the history of Earth, there are many times when intelligent +life was almost extinguished. In addition to the mass extinctions that +wiped out the dinosaurs and most life on Earth, humans have faced +additional near extinctions. For example, humans are all genetically +related to one another to a considerable degree, much closer than two +typical animals of the same species. Although humans may look diverse +from the outside, our genes and internal chemistry tell a different story. +In fact, any two humans are so closely related genetically that we can +actually do the math and calculate when a “genetic Eve” or “genetic +Adam” gave birth to the entire human race. Moreover, we can calculate +how many of us there were in the past." +"The numbers are remarkable. Genetics shows that there were only a +few hundred to a few thousand humans alive about seventy to one +hundred thousand years ago and that they gave birth to the entire +human race. (One theory holds that the titanic explosion of the Toba +volcano in Indonesia about seventy thousand years ago caused +temperatures to drop so dramatically that most of the human race +perished, leaving only a handful to populate Earth.) From that small +band of humans came the adventurers and explorers who would +eventually colonize the entire planet. + +Repeatedly in the history of Earth, intelligent life might have come to +a dead end. It is a miracle we survived. We can also conclude that +although life may exist on other planets, conscious life may exist on only +a tiny fraction of them. So we should treasure the consciousness that is +found on Earth. It is the highest form of complexity known in the +universe, and probably also the rarest." +"Sometimes, when contemplating the future destiny of the human race, +I have to come to grips with the distinct possibility of its self-destruction. +Although volcanic eruptions and earthquakes could spell doom for the +human race, our worst fears may be realized through man-made +disasters, such as nuclear wars or bioengineered germs. If so, then +perhaps the only conscious life-form in this sector of the Milky Way +galaxy might be extinguished. This, I feel, would be a tragedy not just +for us, but for the universe as well. We take for granted that we are + + conscious, but we don’t understand the long, tortuous sequence of +biological events that have transpired to make this possible. Psychologist +Steven Pinker writes, “I would argue that nothing gives life more +purpose than the realization that every moment of consciousness is a +precious and fragile gift.” + +THE MIRACLE OF CONSCIOUSNESS" +"THE MIRACLE OF CONSCIOUSNESS + +Lastly, there is the criticism of science that says to understand something +is to remove its mystery and magic. Science, by lifting the veil +concealing the secrets of the mind, is also making it more ordinary and +mundane. However, the more I learn about the sheer complexity of the +brain, the more amazed I am that something that sits on our shoulders is + +the most sophisticated object we know about in the universe. As Dr. +David Eagleman says, “What a perplexing masterpiece the brain is, and +how lucky we are to be in a generation that has the technology and the +will to turn our attention to it. It is the most wondrous thing we have +discovered in the universe, and it is us.” Instead of diminishing the sense +of wonder, learning about the brain only increases it. + +More than two thousand years ago, Socrates said, “To know thyself is +the beginning of wisdom.” We are on a long journey to complete his +wishes. + +APPENDIX + +QUANTUM CONSCIOUSNESS?" +"APPENDIX + +QUANTUM CONSCIOUSNESS? + +In spite of all the miraculous advances in brain scans and high +technology, some people claim that we will never understand the secret +of consciousness, since consciousness is beyond our puny technology. In +fact, in their view consciousness is more fundamental than atoms, +molecules, and neurons and determines the nature of reality itself. To +them, consciousness is the fundamental entity out of which the material +world is created. And to prove their point, they refer to one of the +greatest paradoxes in all of science, which challenges our very definition +of reality: the Schrodinger’s Cat paradox. Even today, there is no +universal consensus on the question, with Nobel laureates taking +divergent stances. What is at stake is nothing less than the nature of +reality and thought." +"The Schrodinger’s Cat paradox cuts to the very foundation of quantum +mechanics, a field that makes lasers, MRI scans, radio and TV, modern +electronics, the GPS, and telecommunications possible, upon which the +world economy depends. Many of quantum theory’s predictions have +been tested to an accuracy of one part in one hundred billion. + +I have spent my entire professional career working on the quantum +theory. Yet I realize that it has feet of clay. It’s an unsettling feeling +knowing my life’s work is based on a theory whose very foundation is +based on a paradox." +"This debate was sparked by Austrian physicist Erwin Schrodinger, who +was one of the founding fathers of the quantum theory. He was trying to +explain the strange behavior of electrons, which seemed to exhibit both +wave and particle properties. How can an electron, a point particle, have +two divergent behaviors? Sometimes electrons acted like a particle, +creating well-defined tracks in a cloud chamber. Other times, electrons +acted like a wave, passing through tiny holes and creating wavelike +interference patterns, like those on the surface of a pond. + +In 1925, Schrodinger put forward his celebrated wave equation, which" +"In 1925, Schrodinger put forward his celebrated wave equation, which + +bears his name and is one of the most important equations ever written. +It was an instant sensation, and won him the Nobel Prize in 1933. The +Schrodinger equation accurately described the wavelike behavior of +electrons and, when applied to the hydrogen atom, explained its strange +properties. Miraculously, it could also be applied to any atom and +explain most of the features of the periodic table of elements. It seemed +as if all chemistry (and hence all biology) were nothing but solutions of +this wave equation. Some physicists even claimed that the entire +universe, including all the stars, planets, and even us, was nothing but a +solution of this equation. + +But then physicists began to ask a problematic question that resonates +even today: If the electron is described by a wave equation, then what is +waving?" +"In 1927, Werner Heisenberg proposed a new principle that split the +physics community down the middle. Heisenberg’s celebrated +uncertainty principle states that you cannot know both the location and +the momentum of an electron with certainty. This uncertainty was not a +function of how crude your instruments were but was inherent in +physics itself. Even God or some celestial being could not know the +precise location and momentum of an electron. + +So the wave function of Schrodinger actually described the probability +of finding the electron. Scientists had spent thousands of years painfully + + trying to eliminate chance and probabilities in their work, and now +Heisenberg was allowing it in through the back door. + +The new philosophy can be summed up as follows: the electron is a +point particle, but the probability of finding it is given by a wave. And +this wave obeys Schrodinger’s equation and gives rise to the uncertainty +principle." +"The physics community cracked in half. On one side, we had +physicists like Niels Bohr, Werner Heisenberg, and most atomic +physicists eagerly adopting this new formulation. Almost daily, they +were announcing new breakthroughs in understanding the properties of +matter. Nobel Prizes were being handed out to quantum physicists like +Oscars. Quantum mechanics was becoming a cookbook. You did not +need to be a master physicist to make stellar contributions—you just +followed the recipes given by quantum mechanics and you would make +stunning breakthroughs. + +On the other side, we had aging Nobel laureates like Albert Einstein, +Erwin Schrodinger, and Louis de Broglie who were raising philosophical +objections. Schrodinger, whose work helped start this whole process, +grumbled that if he had known that his equation would introduce +probability into physics, he would never have created it in the first +place." +"Physicists embarked on an eighty-year debate that continues even +today. On one hand, Einstein would proclaim that “God does not play +dice with the world.” Niels Bohr, on the other hand, reportedly replied, +“Stop telling God what to do.” + +In 1935, to demolish the quantum physicists once and for all, +Schrodinger proposed his celebrated cat problem. Place a cat in a sealed +box, with a container of poison gas. In the box, there is a lump of +uranium. The uranium atom is unstable and emits particles that can be +detected by a Geiger counter. The counter triggers a hammer, which falls +and breaks the glass, releasing the gas, which can kill the cat." +"How do you describe the cat? A quantum physicist would say that the +uranium atom is described by a wave, which can either decay or not +decay. Therefore you have to add the two waves together. If the uranium +fires, then the cat dies, so that is described by one wave. If the uranium +does not fire, then the cat lives, and that is also described by a wave. To +describe the cat, you therefore have to add the wave of a dead cat to the +wave of a live cat. + +This means that the cat is neither dead nor alive! The cat is in a +netherworld, between life and death, the sum of the wave describing a + + dead cat with the wave of a live cat. + +This is the crux of the problem, which has reverberated in the halls of +physics for almost a century. So how do you resolve this paradox? There +are at least three ways (and hundreds of variations on these three)." +"The first is the original Copenhagen interpretation proposed by Bohr +and Heisenberg, the one that is quoted in textbooks around the world. (It +is the one that I start with when I teach quantum mechanics.) It says that +to determine the state of the cat, you must open the box and make a +measurement. The cat’s wave (which was the sum of a dead cat and a +live cat) now “collapses” into a single wave, so the cat is now known to +be alive (or dead). Thus, observation determines the existence and state +of the cat. The measurement process is thus responsible for two waves + +magically dissolving into a single wave." +"magically dissolving into a single wave. + +Einstein hated this. For centuries, scientists have battled something +called “solipsism” or “subjective idealism,” which claims that objects +cannot exist unless there is someone there to observe them. Only the +mind is real—the material world exists only as ideas in the mind. Thus, +say the solipsists (such as Bishop George Berkeley), if a tree falls in the +forest but no one is there to observe it, perhaps the tree never fell. +Einstein, who thought all this was pure nonsense, promoted an opposing +theory called “objective reality,” which says simply that the universe +exists in a unique, definite state independent of any human observation. +It is the commonsense view of most people." +"Objective reality goes back to Isaac Newton. In this scenario, the atom +and subatomic particles are like tiny steel balls, which exist at definite +points in space and time. There is no ambiguity or chance in locating the +position of these balls, whose motions can be determined by using the +laws of motion. Objective reality was spectacularly successful in +describing the motions of planets, stars, and galaxies. Using relativity, +this idea can also describe black holes and the expanding universe. But +there is one place where it fails miserably, and that is inside the atom. + +Classical physicists like Newton and Einstein thought that objective +reality finally banished solipsism from physics. Walter Lippmann, the +columnist, summed it up when he wrote, “The radical novelty of modern +science lies precisely in the rejection of the belief ... that the forces +which move the stars and atoms are contingent upon the preferences of +the human heart.”" +"But quantum mechanics allowed a new form of solipsism back into +physics. In this picture, before it is observed, a tree can exist in any +possible state (e.g., sapling, burned, sawdust, toothpicks, decayed). But + + when you look at it, the wave suddenly collapses and it looks like a tree. +The original solipsists talked about trees that either fell or didn’t. The +new quantum solipsists were introducing all possible states of a tree. + +This was too much for Einstein. He would ask guests at his house, +“Does the moon exist because a mouse looks at it?” To a quantum +physicist, in some sense the answer might be yes. + +Einstein and his colleagues would challenge Bohr by asking: How can +the quantum microworld (with cats being dead and alive +simultaneously) coexist with the commonsense world we see around us?" +"The answer was that there is a “wall” that separates our world from the +atomic world. On one side of the wall, common sense rules. On the other +side of the wall, the quantum theory rules. You can move the wall if you +want and the results are still the same. + +This interpretation, no matter how strange, has been taught for eighty +years by quantum physicists. More recently, there have been some +doubts cast on the Copenhagen interpretation. Today we have +nanotechnology, with which we can manipulate individual atoms at will. +On a scanning tunneling microscope screen, atoms appear to be fuzzy +tennis balls. (For BBC-TV, I had a chance to fly out to IBM’s Almaden +Lab in San Jose, California, and actually push individual atoms around +with a tiny probe. It is now possible to play with atoms, which were +once thought to be so small they could never be seen.)" +"As we’ve discussed, the Age of Silicon is slowly coming to an end, and +some believe that molecular transistors will replace silicon transistors. If +so, then the paradoxes of the quantum theory may lie at the very heart +of every computer of the future. The world economy may eventually rest +on these paradoxes. + +COSMIC CONSCIOUSNESS AND MULTIPLE UNIVERSES + +There are two alternate interpretations of the cat paradox, which take us +to the strangest realms in all science: the realm of God and multiple +universes. + +In 1967, the second resolution to the cat problem was formulated by +Nobel laureate Eugene Wigner, whose work was pivotal in laying the +foundation of quantum mechanics and also building the atomic bomb. +He said that only a conscious person can make an observation that +collapses the wave function. But who is to say that this person exists? +You cannot separate the observer from the observed, so maybe this" +"person is also dead and alive. In other words, there has to be a new +wave function that includes both the cat and the observer. To make sure +that the observer is alive, you need a second observer to watch the first +observer. This second observer is called “Wigner’s friend,” and is +necessary to watch the first observer so that all waves collapse. But how +do we know that the second observer is alive? The second observer has + +to be included in a still-larger wave function to make sure he is alive, +but this can be continued indefinitely. Since you need an infinite number +of “friends” to collapse the previous wave function to make sure they are +alive, you need some form of “cosmic consciousness,” or God. + +Wigner concluded: “It was not possible to formulate the laws (of +quantum theory) in a fully consistent way without reference to +consciousness.” Toward the end of his life, he even became interested in +the Vedanta philosophy of Hinduism." +"In this approach, God or some eternal consciousness watches over all +of us, collapsing our wave functions so that we can say we are alive. This +interpretation yields the same physical results as the Copenhagen +interpretation, so this theory cannot be disproven. But the implication is +that consciousness is the fundamental entity in the universe, more +fundamental than atoms. The material world may come and go, but +consciousness remains as the defining element, which means that +consciousness, in some sense, creates reality. The very existence of the +atoms we see around us is based on our ability to see and touch them." +"(At this point, it’s important to note that some people think that +because consciousness determines existence, then consciousness can +therefore control existence, perhaps by meditation. They think that we +can create reality according to our wishes. This thinking, as attractive as +it might sound, goes against quantum mechanics. In quantum physics, +consciousness makes observations and therefore determines the state of +reality, but consciousness cannot choose ahead of time which state of +reality actually exists. Quantum mechanics allows you only to determine +the chance of finding one state, but we cannot bend reality to our +wishes. For example, in gambling, it is possible to mathematically +calculate the chances of getting a royal flush. However, this does not +mean that you can somehow control the cards to get the royal flush. You +cannot pick and choose universes, just as we have no control over +whether the cat is dead or alive.) + +MULTIPLE UNIVERSES" +"MULTIPLE UNIVERSES + +The third way to resolve the paradox is the Everett, or many-worlds, + + interpretation, which was proposed in 1957 by Hugh Everett. It is the + +strangest theory of all. It says that the universe is constantly splitting +apart into a multiverse of universes. In one universe, we have a dead cat. +In another universe, we have a live cat. This approach can be +summarized as follows: wave functions never collapse, they just split. +The Everett many-worlds theory differs from the Copenhagen +interpretation only in that it drops the final assumption: the collapse of +the wave function. In some sense, it is the simplest formulation of +quantum mechanics, but also the most disturbing. + +There are profound consequences to this third approach. It means that +all possible universes might exist, even ones that are bizarre and +seemingly impossible. (However, the more bizarre the universe, the +more unlikely it is.)" +"This means people who have died in our universe are still alive in +another universe. And these dead people insist that their universe is the +correct one, and that our universe (in which they are dead) is fake. But if +these “ghosts” of dead people are still alive somewhere, then why can’t +we meet them? Why can’t we touch these parallel worlds? (As strange as +it may seem, in this picture Elvis is still alive in one of these universes.)" +"What’s more, some of these universes may be dead, without any life, +but others may look exactly like ours, except for one key difference. For +example, the collision of a single cosmic ray is a tiny quantum event. But +what happens if this cosmic ray goes through Adolf Hitler’s mother, and +the infant Hitler dies in a miscarriage? Then a tiny quantum event, the +collision of a single cosmic ray, causes the universe to split in half. In +one universe, World War II never happened, and sixty million people did +not have to die. In the other universe, we’ve had the ravages of World +War II. These two universes grow to be quite far apart, yet they are +initially separated by one tiny quantum event." +"This phenomenon was explored by science-fiction writer Philip K. Dick +in his novel The Man in the High Tower, where a parallel universe opens +up because of a single event: a bullet is fired at Franklin Roosevelt, who +is killed by an assassin. This pivotal event means that the United States +is not prepared for World War II, and the Nazis and Japanese are +victorious and eventually partition the United States in half. + +But whether the bullet fires or misfires depends, in turn, on whether a +microscopic spark is set off in the gunpowder, which itself depends on +complex molecular reactions involving the motions of electrons. So + + perhaps quantum fluctuations in the gunpowder may determine whether +the gun fires or misfires, which in turn determines whether the Allies or +the Nazis emerge victorious during World War II." +"So there is no “wall” separating the quantum world and the +macroworld. The bizarre features of the quantum theory can creep into +our “commonsense” world. These wave functions never collapse—they +keep splitting endlessly into parallel realities. The creation of alternative +universes never stops. The paradoxes of the microworld (i.e., being dead +and alive simultaneously, being in two places at the same time, +disappearing and reappearing somewhere else) now enter into our world +as well. + +But if the wave function is continually splitting apart, creating entirely +new universes in the process, then why can’t we visit them?" +"Nobel laureate Steven Weinberg compares this to listening to the radio +in your living room. There are hundreds of radio waves simultaneously +filling up your room from all over the world, but your radio dial is tuned +to only one frequency. In other words, your radio has “decohered” from +all the other stations. (Coherence is when all waves vibrate in perfect +unison, as in a laser beam. Decoherence is when these waves begin to +fall out of phase, so they no longer vibrate in unison.) These other +frequencies all exist, but your radio cannot pick them up because they +are not vibrating at the same frequency that we are anymore. They have +decoupled; that is, they have decohered from us." +"In the same way, the wave function of the dead and alive cat have +decohered as time goes on. The implications are rather staggering. In +your living room, you coexist with the waves of dinosaurs, pirates, aliens +from space, and monsters. Yet you are blissfully unaware that you are +sharing the same space as these strange denizens of quantum space, +because your atoms are no longer vibrating in unison with them. These +parallel universes do not exist in some distant never-never land. They +exist in your living room. + +Entering one of these parallel worlds is called “quantum jumping” or +“sliding” and is a favorite gimmick of science fiction. To enter a parallel +universe, we need to take a quantum jump into it. (There was even a TV +series called Sliders where people slide back and forth between parallel +universes. The series began when a young boy read a book. That book is +actually my book Hyperspace, but I take no responsibility for the physics + +behind that series.)" +"behind that series.) + +Actually, it’s not so simple to jump between universes. One problem +we sometimes give our Ph.D. students is to calculate the probability that + + you will jump through a brick wall and wind up on the other side. The +result is sobering. You would have to wait longer than the lifetime of the +universe to experience jumping or sliding through a brick wall. + +LOOKING IN THE MIRROR" +"LOOKING IN THE MIRROR + +When I look at myself in a mirror, I don’t really see myself as I truly am. +First, I see myself about a billionth of a second ago, since that is the time +that it takes a light beam to leave my face, hit a mirror, and enter my +eyes. Second, the image I see is really an average over billions and +billions of wave functions. This average certainly does resemble my +image, but it is not exact. Surrounding me are multiple images of myself +oozing in all directions. I am continually surrounded by alternate +universes, forever branching into different worlds, but the probability of +sliding between them is so tiny that Newtonian mechanics seems to be +correct." +"At this point, some people ask this question: Why don’t scientists +simply do an experiment to determine which interpretation is valid? If +we run an experiment with an electron, all three interpretations will +yield the same result. All three are therefore serious, viable +interpretations of quantum mechanics, with the same underlying +quantum theory. What is different is how we explain the results. + +Hundreds of years in the future, physicists and philosophers may still +be debating this question, with no resolution, because all three +interpretations yield the same physical results. But perhaps there is one +way in which this philosophical debate touches on the brain, and that is +the question of free will, which in turn affects the moral foundation of +human society. + +FREE W ILT. + +Our entire civilization is based on the concept of free will, which +impacts on the notions of reward, punishment, and personal" +"responsibility. But does free will really exist? Or is it a clever way of +keeping society together although it violates scientific principles? The +controversy goes to the very heart of quantum mechanics itself. + +It is safe to say that more and more neuroscientists are gradually +coming to the conclusion that free will does not exist, at least not in the +usual sense. If certain bizarre behaviors can be linked to precise defects + + in the brain, then a person is not scientifically responsible for the crimes +he might commit. He might be too dangerous to be left walking the +streets and must be locked up in an institution of some sort, but +punishing someone for having a stroke or tumor in the brain is +misguided, they say. What that person needs is medical and +psychological help. Perhaps the brain damage can be treated (e.g., by +removing a tumor), and the person can become a productive member of +society." +"For example, when I interviewed Dr. Simon Baron-Cohen, a +psychologist at Cambridge University, he told me that many (but not all) +pathological killers have a brain anomaly. Their brain scans show that +they lack empathy when seeing someone else in pain, and in fact they +might even take pleasure in watching this suffering (in these individuals, +the amygdala and the nucleus accumbens, the pleasure center, light up +when they view videos of people experiencing pain). + +The conclusion some might draw from this is that these people are not +truly responsible for their heinous acts, although they should still be +removed from society. They need help, not punishment, because of a +problem with their brain. In a sense, they may not be acting with free +will when they commit their crimes." +"An experiment done by Dr. Benjamin Libet in 1985 casts doubt on the +very existence of free will. Let’s say that you are asking subjects to watch +a clock and then to note precisely when they decide to move a finger. +Using EEG scans, one can detect exactly when the brain makes this +decision. When you compare the two times, you will find a mismatch. +The EEG scans show that the brain has actually made the decision about +three hundred milliseconds before the person becomes aware of it. + +This means that, in some sense, free will is a fake. Decisions are made +ahead of time by the brain, without the input of consciousness, and then +later the brain tries to cover this up (as it’s wont to do) by claiming that +the decision was conscious. Dr. Michael Sweeney concludes, “Libet’s + +findings suggested that the brain knows what a person will decide before +the person does.... The world must reassess not only the idea of +movements divided between voluntary and involuntary, but also the +very idea of free will.”" +"All this seems to indicate that free will, the cornerstone of society, is a +fiction, an illusion created by our left brain. So are we masters of our +fate, or just pawns in a swindle perpetuated by the brain? + +There are several ways to approach this sticky question. Free will goes +against a philosophy called determinism, which simply says that all + + future events are determined by physical laws. According to Newton +himself, the universe was some sort of clock, ticking away since the +beginning of time, obeying the laws of motion. Hence all events are +predictable. + +The question is: Are we part of this clock? Are all our actions also +determined? These questions have philosophical and theological +implications. For example, most religions adhere to some form of +determinism and predestination. Since God is omnipotent, omniscient, +and omnipresent, He knows the future, and hence the future is +determined ahead of time. He knows even before you are born whether +you will go to Heaven or Hell." +"The Catholic Church split in half on this precise question during the +Protestant revolution. According to Catholic doctrine at that time, one +could change one’s ultimate fate with an indulgence, usually by making +generous financial donations to the Church. In other words, determinism +could be altered by the size of your wallet. Martin Luther specifically +singled out the corruption of the Church over indulgences when he +tacked his 95 Theses on the door of a church in 1517, triggering the +Protestant Reformation. This was one of the key reasons why the Church +split down the middle, causing casualties in the millions and laying +waste to entire regions of Europe." +"But after 1925, uncertainty was introduced into physics via quantum +mechanics. Suddenly everything became uncertain; all you could +calculate was probabilities. In this sense, perhaps free will does exist, +and it’s a manifestation of quantum mechanics. So some claim that the +quantum theory reestablishes the concept of free will. The determinists +have fought back, however, claiming that quantum effects are extremely +small (at the level of atoms), too small to account for the free will of + +large human beings. + +The situation today is actually rather muddled. Perhaps the question +“Does free will exist?” is like the question “What is life?” The discovery +of DNA has rendered that question about life obsolete. We now realize +that the question has many layers and complexities. Perhaps the same +applies to free will, and there are many types." +"If so, the very definition of “free will” becomes ambiguous. For +example, one way to define free will is to ask whether behavior can be +predicted. If free will exists, then behavior cannot be determined ahead +of time. Let’s say you watch a movie, for example. The plot is completely +determined, with no free will whatsoever. So the movie is completely +predictable. But our world cannot be like a movie, for two reasons. The +first is the quantum theory, as we have seen. The movie represents only + + one possible timeline. The second reason is chaos theory. Although +classical physics says that all of the motions of atoms are completely +determined and predictable, in practice it is impossible to predict their +motions because there are so many atoms involved. The slightest +disturbance of a single atom can have a ripple effect, which can cascade +down to create enormous disturbances." +"Think of the weather. In principle, if you knew the behavior of every +atom in the air, you could predict the weather a century from now if you +had a big enough computer. But in practice, this is impossible. After just +a few hours, the weather becomes so turbulent and complex that any +computer simulation is rendered useless. + +This creates what is called the “butterfly effect,” which means that +even the beat of butterfly wings can cause tiny ripples in the +atmosphere, which grow and in turn can escalate into a thunderstorm. +So if even the flapping of butterfly wings can create thunderstorms, the +hope of accurately predicting the weather is far-fetched. + +Let’s go back to the thought experiment described to me by Stephen +Jay Gould. He asked me to imagine Earth 4.5 billion years ago, when it +was born. Now imagine you could somehow create an identical copy of +Earth, and let it evolve. Would we still be here on this different Earth 4.5 +billion years later?" +"One could easily imagine, due to quantum effects or the chaotic nature +of the weather and oceans, that humanity would never evolve into +precisely the same creatures on this version of Earth. So ultimately, it + +seems a combination of uncertainty and chaos makes a perfectly +deterministic world impossible. + +THE QUANTUM BRAIN + +This debate also affects the reverse engineering of the brain. If you can +successfully reverse engineer a brain made of transistors, this success +implies that the brain is deterministic and predictable. Ask it any +question and it repeats the exact same answer. Computers are +deterministic in this way, since they always give the same answer for +any question. + +So it seems we have a problem. On one hand, quantum mechanics and +chaos theory claim that the universe is not predictable, and therefore, +free will seems to exist. But a reverse-engineered brain, made of +transistors, would by definition be predictable. Since the reverse-" +"engineered brain is theoretically identical to a living brain, then the +human brain is also deterministic and there is no free will. Clearly, this +contradicts the first statement." +"A minority of scientists claim that you cannot authentically reverse +engineer the brain, or ever create a true thinking machine, because of +the quantum theory. The brain, they argue, is a quantum device, not just +a collection of transistors. Hence this project is doomed to fail. In this +camp is Oxford physicist Dr. Roger Penrose, an authority on Einstein’s +theory of relativity, who claims that it is quantum processes that may +account for the consciousness of the human brain. Penrose starts by +saying that mathematician Kurt Godel has proven that arithmetic is +incomplete; that is, that there are true statements in arithmetic that +cannot be proven using the axioms of arithmetic. Similarly, not only is +mathematics incomplete, but so is physics. He concludes by stating that +the brain is basically a quantum mechanical device and there are +problems that no machine can solve because of Godel’s incompleteness +theorem. Humans, however, can make sense of these conundrums using +intuition." +"Similarly, the reverse-engineered brain, no matter how complex, is +still a collection of transistors and wires. In such a deterministic system, +you can accurately predict its future behavior because the laws of + +motion are well known. In a quantum system, however, the system is +inherently unpredictable. All you can calculate are the chances that +something will occur, because of the uncertainty principle. + +If it turns out that the reverse-engineered brain cannot reproduce +human behavior, then scientists may be forced to admit that there are +unpredictable forces at work (i.e., quantum effects inside the brain). Dr. +Penrose argues that inside the neuron there are tiny structures, called +microtubules, where quantum processes dominate." +"At present, there is no consensus on this problem. Judging from the +reaction to Penrose’s idea when it was first proposed, it would be safe to +say that most of the scientific community is skeptical of his approach. +Science, however, is never conducted as a popularity contest, but instead +advances through testable, reproducible, and falsifiable theories. + +For my own part, I believe transistors cannot truly model all the +behaviors of neurons, which carry out both analog and digital +calculations. We know that neurons are messy. They can leak, misfire, +age, die, and are sensitive to the environment. To me, this suggests that +a collection of transistors can only approximately model the behavior of +neurons. For example, we saw earlier, in discussing the physics of the +brain, that if the axon of the neuron becomes thinner, then it begins to" +"leak and also does not carry out chemical reactions that well. Some of +this leakage and these misfires will be due to quantum effects. As you try +to imagine neurons that are thinner, denser, and faster, quantum effects +become more obvious. This means that even for normal neurons there +are problems of leakage and instabilities, and these problems exist both +classically and quantum mechanically. + +In conclusion, a reverse-engineered robot will give a good but not +perfect approximation of the human brain. Unlike Penrose, I think it is +possible to create a deterministic robot out of transistors that gives the +appearance of consciousness, but without any free will. It will pass the +Turing test. But I think there will be differences between such a robot +and humans due to these tiny quantum effects." +"Ultimately, I think free will probably does exist, but it is not the free +will envisioned by rugged individualists who claim they are complete +masters of their fate. The brain is influenced by thousands of +unconscious factors that predispose us to make certain choices ahead of +time, even if we think we made them ourselves. This does not + +necessarily mean that we are actors in a film that can be rewound +anytime. The end of the movie hasn’t been written yet, so strict +determinism is destroyed by a subtle combination of quantum effects +and chaos theory. In the end, we are still masters of our destiny. + +NOTES + +INTRODUCTION" +"NOTES + +INTRODUCTION + +1 You may have to travel: To see this, define “complex” in terms of the +total amount of information that can be stored. The closest rival to the +brain might be the information contained within our DNA. There are +three billion base pairs in our DNA, each one containing one of four +nucleic acids, labeled A,T,C,G. Therefore the total amount of +information we can store in our DNA is four raised to the three- +billionth power. But the brain can store much more information +among its one hundred billion neurons, which can either fire or not +fire. Hence, there are two raised to the one-hundred-billionth power +possible initial states of the human brain. But while DNA is static, the +states of the brain change every few milliseconds. A simple thought +may contain one hundred generations of neural firings. Hence, there +are two raised to one hundred billion, all raised to the hundredth +power, possible thoughts contained in one hundred generations. But" +"our brains are continually firing, day and night, ceaselessly +computing. Therefore the total number of thoughts possible within N +generations is two raised to the one-hundred-billionth power, all +raised to the Nth power, which is truly astronomical. Therefore the +amount of information that we can store in our brains far exceeds the +information stored within our DNA by a wide margin. In fact, it is the +largest amount of information that we can store in our solar system, +and even possibly in our sector of the Milky Way galaxy. + +2 “The most valuable insights”: Boleyn-Fitzgerald, p. 89. + +3 “All of these questions that philosophers”: Boleyn-Fitzgerald, p. +137. + +CHAPTER 1: UNLOCKING THE MIND + +1 He was semiconscious for weeks: See Sweeney, pp. 207-8. + +2 Dr. John Harlow, the doctor who treated: Carter, p. 24. + +3 In the year A.D. 43, records show: Horstman, p. 87. + +4 “It was like ... standing in the doorway”: Carter, p. 28. + +5 The Transparent Brain: New York Times, April 10, 2013, p. 1." +"5 The Transparent Brain: New York Times, April 10, 2013, p. 1. + +6 “Emotions are not feelings at all”: Carter, p. 83. + +7 the mind is more like a “society of minds”: Interview with Dr. +Minsky for the BBC-TV series Visions of the Future, February 2007. +Also, interview for Science Fantastic national radio broadcast, +November 2009. + +8 consciousness was like a storm raging: Interview with Dr. Pinker in +September 2003 for Exploration national radio broadcast. + +9 “the intuitive feeling we have”: Pinker, “The Riddle of Knowing +You’re Here,” in Your Brain: A User’s Guide (New York: Time Inc. +Specials, 2011). + +10 Consciousness turns out to consist of: Boleyn-Fitzgerald, p. 111. + +11 “indeed a conscious system in its own right”: Carter, p. 52. + +12 I asked him how experiments: Interview with Dr. Michael +Gazzaniga in September 2012 for Science Fantastic national radio +broadcast. + + 13 “The possible implications of this”: Carter, p. 53. + +14 “If that person dies, what happens?”: Boleyn-Fitzgerald, p. 119." +"14 “If that person dies, what happens?”: Boleyn-Fitzgerald, p. 119. + +15 a young king who inherits: Interview with Dr. David Eagleman in +May 2012 for Science Fantastic national radio broadcast. + +16 “people named Denise or Dennis”: Eagleman, p. 63. + +17 “at least 15 % of human females”: Eagleman, p. 43. + +CHAPTER 2: CONSCIOUSNESS—A PHYSICIST’S VIEWPOINT + +1 “We cannot see ultraviolet light”: Pinker, How the Mind Works, pp. +561-65. + +2 “Everybody knows what consciousness is”: Biological Bulletin 215, +no. 3 (December 2008): 216." +"2 “Everybody knows what consciousness is”: Biological Bulletin 215, +no. 3 (December 2008): 216. + +3 We will do so in the notes: Level II consciousness can be counted by +listing the total number of distinct feedback loops when an animal +interacts with members of its species. As a rough guess, Level II +consciousness can be approximated by multiplying the number of +others in an animal’s pack or tribe, multiplied by the total number of +distinct emotions or gestures it uses to communicate with others. +There are caveats to this ranking, however, since this is just a first +guess. + +For example, animals like the wildcat are social, but they are also +solitary hunters, so it appears as if the number of animals in its pack is +one. But that is true only when it is hunting. When it is time to +reproduce, wildcats engage in complex mating rituals, so its Level II +consciousness must take this into account." +"Furthermore, when female wildcats give birth to litters of kittens, +which have to be nursed and fed, the number of social interactions +increases as a consequence. So even for solitary hunters, the number +of members of its species that it interacts with is not one, and the total +number of distinct feedback loops can be quite large. + +Also, if the number of wolves in the pack decreases, then it appears +as if its Level II number decreases correspondingly. To account for +this, we have to introduce the concept of an average Level II number +that is common for the entire species, as well as a specific Level II +consciousness for an individual animal. + + The average Level II number for a given species does not change if +the pack gets smaller, because it is common for the entire species, but +the individual Level II number (because it measures individual mental +activity and consciousness) does change." +"When applied to humans, the average Level II number must take +into account the Dunbar number, which is 150, and represents roughly + +the number of people in our social grouping that we can keep track of. +So the Level II number for humans as a species would be the total +number of distinct emotions and gestures we use to communicate, +multiplied by the Dunbar number of 150. (Individuals can have +different levels of Level II consciousness, since their circle of friends +and the ways they interact with them can vary considerably.) + +We should also note that certain Level I organisms (like insects and +reptiles) can exhibit social behaviors. Ants, when they bump into one +another, exchange information via chemical scents, and bees dance to +communicate the location of flower beds. Reptiles even have a +primitive limbic system. But in the main, they do not exhibit +emotions. + +4 “The difference between man”: Gazzaniga, p. 27. + +5 “The greatest achievement of the human brain”: Gilbert, p. 5." +"5 “The greatest achievement of the human brain”: Gilbert, p. 5. + +6 “area 10 (the internal granular layer IV)”: Gazzaniga, p. 20. + +7 The male gets confused, because it wants: Eagleman, p. 144. + +8 “I predict that mirror neurons”: Brockman, p. xiii. + +9 Biologist Carl Zimmer writes: Bloom, p. 51. + +10 “Most of the time we daydream”: Bloom, p. 51. + +Ill asked one person who may: Interview with Dr. Michael Gazzaniga +in September 2012 for Science Fantastic national radio broadcast. + +12 “It is the left hemisphere”: Gazzaniga, p. 85. + +CHAPTER 3: TELEPATHY—A PENNY FOR YOUR THOUGHTS + +1 Indeed, in a recent “Next 5 in 5”: http://www.ibm.com/5in5. + +2 I had the pleasure of touring: Interview with Dr. Gallant on July 11, + + 2012, at the University of California, Berkeley. Also, interview with +Dr. Gallant on Science Fantastic for national radio, July 2012. + +3 “This is a major leap forward”: Berkeleyan Newsletter, September +22, 2011, http://newscenter.berkeley.edu/2011/09/22/brain-movies." +"4 “If you take 200 voxels”: Brockman, p. 236. + +5 Dr. Brian Pasley and his colleagues: Visit to Dr. Pasley’s laboratory +on July 11, 2012, at the University of California, Berkeley. + +6 Similar results were obtained: The Brain Institute, University of +Utah, Salt Lake City, http://brain.utah.edu. + +7 This could have applications for artists: http://io9/543338/a- +device-that-lets-io9.com/543338/a-device-that-lets-ou-type-with-your- +mind. + +8 According to their officials: http://news.discovery.com/tech/type- +with-your-mind-110309.html. + +9 being explored by Dr. David Poeppel: Discover Magazine Presents the +Brain, Spring 2012, p. 43. + +10 In 1993 in Germany: Scientific American, November 2008, p. 68. + +11 The only justification for its existence: Garreau, pp. 23-24. + +12 I once had lunch with: Symposium on the future of science +sponsored by the Science Fiction Channel at the Chabot Pace and +Science Center, Oakland, California, in May 2004." +"13 On another occasion: Conference in Anaheim, California, April +2009. + +14 He says, “Imagine if soldiers”: Garreau, p. 22. + +15 “What he is doing is spending”: Ibid., p. 19. + +16 When I asked Dr. Nishimoto: Visit to Dr. Gallant’s laboratory at the +University of California, Berkeley, on July 11, 2012. + +17 “There are ethical concerns”: http://www.nbcnews.com/ +id/47447302/ns/health-health_care/t/paralyzed-woman-gets-robotic- +arm.html. + +CHAPTER 4: TELEKINESIS: MIND CONTROLLING MATTER + + 1 “I would love to have”: New York Times, May 17, 2012, p. A17 and +http://www.msnbc.mns.eom/id/47447302/ns/health-health_care/t/ +parallyzed-woman-gets-robotic-arm.html. + +2 “We have taken a tiny sensor”: Interview with Dr. John Donoghue in +November 2009 for Science Fantastic national radio broadcast. + +3 In the United States alone, more than two hundred thousand: + +Centers for Disease Control and Prevention, Washington, D.C. http:// +www. ede. go v/traumatiebraininj ury/scifacts. html ." +"4 When the monkey wanted to move: + +http://physio.northwestern.edu/faculty/miller.htm; http://www. + +northwestern.edu/newscenter/stories/2012/04/miller-paralyzed- + +technology.html. + +5 “We are eavesdropping on the natural”: http://www.northwestern. +edu/newscenter/stories/2012/04/miller-paralyzed-technology.html. + +6 More than 1,300 service members: http://www.darpa.mil/Our_ +Work/DSO/Programs/Revolutionizing_Prosthetics.aspx. CBS 60 +Minutes, broadcast on December 30, 2012. + +7 “They thought we were crazy”: Ibid. + +8 she appeared on 60 Minutes: Ibid. + +9 “There’s going to be a whole ecosystem”: Wall Street Journal, May +29, 2012. + +10 But perhaps the most novel applications: Interview with Dr. +Nicolelis in April 2011 for Science Fantastic national radio broadcast." +"11 Smart Hands and Mind Melds: New York Times, March 13, 2013, +http://nytimes.com/2013/03/01/science/new-research-suggests-two- +rat-brains-can-be-linked. See also Huffington Post, February 28, 2013, +http://www.huffingtonpost.com/2013/02/28/mind-melds-brain- +communication_n_2781609.html. + +12 In 2013, the next important step: USA Today, August 8, 2013, p. +ID. + + 13 About ten years ago: Interview with Dr. Nicolelis in April 2011. + +14 “so there’s nothing sticking out”: For a full discussion of the +exoskeleton, see Nicolelis, pp. 303-7. + +15 The Honda Corporation has: http://www.asimo.honda.com. Also, +interview with the creators of ASIMO in April 2007 for the BBC-TV +series Visions of the Future. + +16 Eventually, you get the hang: http://discovermagazine.com/2007/ +may/re vie w-test- driving- the -future . + +17 Then, by thinking, the patient: Discover, December 9, 2011, http:// +discovermagazine.com/2011/dec/09-mind-over-motor-controlling- +robots-with-your-thoughts." +"18 “We will likely be able to operate”: Nicolelis, p. 315. + +19 I saw a demonstration of this: Interview with the scientists at +Carnegie Mellon in August 2010 for the Discovery/Science Channel TV +series Sci Fi Science. + +CHAPTER 5: MEMORIES AND THOUGHTS MADE TO ORDER + +1 “It has all come together”: Wade, p. 89. + +2 So far, scientists have identified: Ibid., p. 91. + +3 For instance, Dr. Antonio Damasio: Damasio, pp. 130-53. + +4 One fragment of memory might: Wade, p. 232. + +5 “If you can’t do it”: http://www.newscientist.com/article/dn3488. + +6 “Turn the switch on”: http://www.eurekalert.org/pub_releases/2011- +06/uosc-rmr06211 .php. + +7 “Using implantables to enhance competency”: http://hplus +magazine.com/2009/03/18/artificial-hipppocampus. + +8 Not surprisingly, with so much at stake: http://articles. +washingtonpost.com/2013-07-12/national/40863765_l_brain-cells- +mice-new-memories." +"9 If encoding the memory: This brings up the question of whether +carrier pigeons, migratory birds, whales, etc., have a long-term +memory, given that they can migrate over hundreds to thousands of + + miles in search of feeding and breeding grounds. Science knows little +about this question. But it is believed that their long-term memory is +based on locating certain landmarks along the way, rather than +recalling elaborate memories of past events. In other words, they do +not use memory of past events to help them simulate the future. Their +long-term memory consists of just a series of markers. Apparently, +only in humans are long-term memories used to help simulate the +future. + +10 “The purpose of memory is”: Michael Lemonick, “Your Brain: A +User’s Guide,” Time, December 2011, p. 78. + +11 “You might look at it”: http://sciencedaily.com/videos/2007/0210- +brain_scans_of_the_future.htm. + +12 their study proves a “tentative answer”: http://www.sciencedaily. +com/videos/2007/0710." +"12 their study proves a “tentative answer”: http://www.sciencedaily. +com/videos/2007/0710. + +13 “The whole idea is that the device”: New York Times, September + +12, 2012, p. A18. + +14 “It will likely take us”: http://www.tgdaily.com/general-sciences- +features/58736-artificial-cerebellum-restores-rats. + +15 There are 5.3 million Americans: Alzheimer’s Foundation of +America, http://www.alzfdn.org. + +16 “This adds to the notion”: ScienceDaily.com, October 2009, http:// +www.sciencedaily.com/releases/2009/10/091019122647.htm. + +17 “We can never turn it into”: Ibid. + +18 “This implies these flies have”: Wade, p. 113. + +19 This effect is not just restricted: Ibid. + +20 “We can now give you”: Ibid., p. 114. + +21 Basically, the more CREB proteins: Bloom, p. 244. + +22 “Propranolol sits on that nerve cell”: SATI e-News, June 28, 2007, +http://www.mysati.com/enews/June2007/ptsd.htm. + +23 Its report concluded: Boleyn-Fitzgerald, p. 104. + +24 “Our breakups, our relationships”: Ibid." +"23 Its report concluded: Boleyn-Fitzgerald, p. 104. + +24 “Our breakups, our relationships”: Ibid. + + 25 “should we deprive them of morphine”: Ibid., p. 105. + +26 “If further work confirms this view”: Ibid., p. 106. + +27 “Each of these perennial records”: Nicolelis, p. 318. + +28 “Forgetting is the most beneficial process”: New Scientist, March +12, 2003, http://www.newscientists.com/article/dn3488. + +CHAPTER 6: EINSTEIN’S BRAIN AND ENHANCING INTELLIGENCE + +1 “got caught up in the moment”: + +http://abcnews.go.com/blogs/headlines/2012/03/einsteins-brain- + +arrives-in-london-after-odd-journey. + +2 “I have always maintained that”: Gould, p. 109. + +3 “The human brain remains ‘plastic’ ”: www.sciencedaily.com/ +releases/2011/12/111208257120.htm. + +4 “The emerging picture from such studies”: Gladwell, p. 40. + +5 Five years later, Terman started: See C. K. Holahan and R.R. Sears, +The Gifted Group in Later Maturity (Stanford, CA: Stanford University +Press, 1995)." +"6 “Your grades in school”: Boleyn-Fitzgerald, p. 48. + +7 “Tests don’t measure motivation”: Sweeney, p. 26. + +8 The pilots who scored highest: Bloom, p. 12. + +9 “The left hemisphere is responsible”: Ibid., p. 15. + +10 Dr. Darold Treffert, a Wisconsin physician: http://www.darold +treffert.com. + +11 It took him just forty-five seconds: Tammet, p. 4. + +12 I had the pleasure of interviewing: Interview with Mr. Daniel +Tammet in October 2007 for Science Fantastic national radio broadcast. + +13 “Our study confirms”: Science Daily, March 2012, http://www. +sciencedaily.com/releases/2012/03/120322100313.htm. + + 14 Kim Peek’s brain: AP wire story, November 8, 2004, http://www. +Space.com. + +15 In 1998 , Dr. Bruce Miller: Neurology 51 (October 1998): pp. 978- +82. See also http://www.wisconsinmedicalsociety.org/savant_ +syndrome/savant-articles/acquired_savant. + +16 In addition to the savants: Sweeney, p. 252." +"16 In addition to the savants: Sweeney, p. 252. + +17 This idea has actually been tried: Center of the Mind, Sydney, +Australia, http://www.centerofthemind.com. + +18 In another experiment, Dr. R. L. Young: R. L. Young, M. C. +Ridding, and T. L. Morrell, “Switching Skills on by Turning Off Part of +the Brain,” Neurocase 10 (2004): 215, 222. + +19 “When applied to the prefrontal lobes”: Sweeney, p. 311. + +20 Until recently, it was thought: Science Daily, May 2012, http:// +www.sciencedaily.com/releases/2012/05/120509180113.htm. + +21 “Savants have a high capacity”: Ibid. + +22 In 2007 , a breakthrough occurred: Sweeney, p. 294. + +23 “Stem cell research and regenerative medicine”: Sweeney, p. 295. + +24 Scientists have focused on a few genes: Katherine S. Pollard, +“What Makes Us Different,” Scientific American Special Collectors Edition +(Winter 2013): 31-35. + +25 “I jumped at the opportunity”: Ibid. + +26 “With my mentor David Haussler”: Ibid." +"25 “I jumped at the opportunity”: Ibid. + +26 “With my mentor David Haussler”: Ibid. + +27 One such gene was discovered: TG Daily, November 15, 2012. +http://www.tgdaily.com/general-sciences-features/67503-new-found- +gene-separates-man-from-apes. + +28 Many theories have been proposed: See, for example, Gazzaniga, +Human: The Science Behind What Makes Us Unique. + +29 “For the first few hundred million years”: Gilbert, p. 15. + +30 “Cortical gray matter neurons are working”: Douglas Fox, “The +Limits of Intelligence,” Scientific American, July 2011, p. 43. + +31 “You might call it the mother”: Ibid., p. 42. + + CHAPTER 7: IN YOUR DREAMS + +1 He followed this up with one thousand: C. Hall and R. Van de + +Castle, The Content Analysis of Dreams (New York: Appleton-Century- +Crofts, 1966). + +2 When I interviewed him, he told me: Interview with Dr. Allan +Hobson in July 2012 for Science Fantastic national radio broadcast. + +3 Studies have shown that it is possible: Wade, p. 229." +"3 Studies have shown that it is possible: Wade, p. 229. + +4 ATR chief scientist Yukiyasu Kamitani: New Scientist, December 12, + +2008, http://www.newscientist.com/article/dnl 6267-mindreading- + +software-could-record-your-dreams.html#.UvE9P0Qi07s. + +5 When I visited the laboratory: Visit to Dr. Gallant’s laboratory on +July 11, 2012. + +6 “Our dreams are therefore not”: Science Daily, October 28, 2011, +http://www.sciencedaily.com/releases/2011/10/111028113626.htm. + +7 Already, prototypes of Internet contact lenses: See the work of Dr. +Babak Parviz, http://www.wearable-technologies.com/262. + +CHAPTER 8: CAN THE MIND BE CONTROLLED? + +1 A raging bull is released: Miguel Nicolelis, Beyond Boundaries (New +York: Henry Holt, 2011), pp. 228-32. + +2 The cold war hysteria eventually reached: “Project MKUltra, the" +"2 The cold war hysteria eventually reached: “Project MKUltra, the + +CIA’s Program of Research into Behavioral Modification. Joint +Hearings Before the Select Committee on Human Resources, U.S. +Senate, 95th Congress, First Session,” Government Printing Office, +August 8, 1977, Washington, D.C., http://www.nytimes.com/ + +packages/pdf/national/13inmate_ProjectMKULTRA.pdf; “CIA Says It +Found More Secret Papers on Behavior Control,” New York Times, +September 3, 1977; “Government Mind Control Records of MKUltra +and Bluebird/Artichoke,” http://wanttoknow.info/mindcontrol.shtml; +“The Select Committee to Study Governmental Operations with" +"Respect to Intelligence Activities, Foreign and Military Intelligence.” +The Church Committee Report No. 94-755, 94th Congress, 2nd +Session, p. 392, Government Printing Office, Washington, D.C., 1976; +“Project MKUltra, the CIA’s Program of Research in Behavior +Modification,” http://scribd.com/doc/75512716/Project-MKUltra- +The-CIA-s-Program-of-Research-in-Behavior-Modification. + +3 “great potential for development”: Rose, p. 292. + +4 “neuro-scientific impossibility”: Ibid., p. 293. + +5 “It is probably significant that”: “Hypnosis in Intelligence,” Black +Vault Freedom of Information Act Archive, 2008, http://documents. +theblackvault.com/documents/mindcontrol/hypnosisinintelligence. +pdf. + +6 To see how widespread this problem: Boleyn-Fitzgerald, p. 57. + +7 Drugs like LSD: Sweeney, p. 200. + +8 “This is the first time we’ve shown”: Boleyn-Fitzgerald, p. 58. + +9 “If you want to turn off”: http://www.nytimes.com/2011/05/17/ +science/17optics.html." +"9 “If you want to turn off”: http://www.nytimes.com/2011/05/17/ +science/17optics.html. + +10 “By feeding information from sensors”: New York Times, March 17, +2011, http://nytimes.com/2011/05/17/science/17optics.html. + +CHAPTER 9: ALTERED STATES OF CONSCIOUSNESS + +1 “Some fraction of history’s prophets”: Eagleman, p. 207. + +2 “Sometimes it’s a personal God”: Boleyn-Fitzgerald, p. 122. + +3 “ ‘Finally, I see what it is’ ”: Ramachandran, p. 280. + +4 “During the three minute bursts”: David Biello, Scientific American, +p. 41, www.sciammind.com. + +5 To test these ideas: Ibid., p. 42. + +6 “Although atheists might argue”: Ibid., p. 45. + +7 “If you are an atheist”: Ibid., p. 44. + +8 One theory holds that Parkinson’s: Sweeney, p. 166. + + 9 “Neurons wired for the sensation”: Ibid., p. 90. + +10 “The brain’s gonna do what”: Ibid., p. 165. + +11 “Brain scans have led researchers”: Ibid., p. 208. + +12 “If left unchecked, the left hemisphere”: Ramachandran, p. 267. + +13 Underactivity in this area: Carter, pp. 100-103." +"13 Underactivity in this area: Carter, pp. 100-103. + +14 Ten percent of them, in turn: Baker, pp. 46-53. + +15 “Depression 1.0 was psychotherapy”: Ibid., p. 3. + +16 One to three percent of DBS patients: Carter, p. 98. + +17 “The calcium channels findings suggest”: New York Times, + +February 26, 2013, http://www.nytimes.com/2013/03/01/ + +health/study-finds-genetic-risk-factors-shared-by-5-psychiatric- +disorders.html. + +18 “What we have identified here”: Ibid. + +CHAPTER 10: THE ARTIFICIAL MIND AND SILICON CONSCIOUSNESS + +1 “Machines will be capable”: Crevier, p. 109. + +2 “within a generation ... the problem”: Ibid. + +3 “It’s as though a group of people”: Kaku, p. 79. + +4 “I would pay a lot for a robot”: Brockman, p. 2. + +5 However, I met privately with: Interview with the creators of ASIMO +during a visit to Honda’s laboratory in Nagoya, Japan, in April 2007 +for the BBC-TV series Visions of the Future." +"6 he used to marvel at the mosquito: Interview with Dr. Rodney +Brooks in April 2002 for Exploration national radio broadcast. + +7 I have had the pleasure of visiting: Visit to MIT Media Laboratory +for the Discovery/Science Channel TV series Sci Fi Science, April 13, +2010 . + +8 “That is why Breazeal decided”: Moss, p. 168. + + 9 At Waseda University: Gazzaniga, p. 352. + +10 Their goal is to integrate: Ibid., p. 252. + +11 Meet Nao: Guardian, August 9, 2010, http://www.theguardian.com/ +technology/2010/aug/09/nao-robot-develop-display-emotions. + +12 “It’s hard to predict the future”: http://cosmomagazine.com/news/ +4177/reverse-engineering-brain. + +13 Neuroscientists like Dr. Antonio Damasio: Damasio, pp. 108-29. + +14 “In mathematics, you don’t understand”: Kurzweil, p. 248. + +15 “There could not be an objective test”: Pinker, “The Riddle of +Knowing You’re Here,” Your Brain: A User’s Guide, Winter, 2011, p. 19. + +16 At Meiji University: Gazzaniga, p. 352." +"16 At Meiji University: Gazzaniga, p. 352. + +17 “To our knowledge, this is the first”: Kurzweil.net, August 24, + +2012, http://www.kurzweilai.net/robot-learns-self-awareness. See also +Yale Daily News, September 25, 2012, + +http://yaledailynews.com/blog/2012/09/25/first-self-aware-robot- +created. + +18 When I interviewed Dr. Hans Moravec: Interview with Dr. Hans +Moravec in November 1998 for Exploration national radio broadcast. + +19 “Unleashed from the plodding pace”: Sweeney, p. 316. + +20 When I interviewed Dr. Rodney Brooks: Interview with Dr. Brooks +in April 2002 for Exploration national radio broadcast. + +21 “We don’t like to give up”: TEDTalks, http://www.ted.com/talks/ +lang/en/rodney_brooks_on_robots.html. + +22 Similarly, at the University of Southern California: http://phys. +org/news205059692.html. + +CHAPTER 11: REVERSE ENGINEERING THE BRAIN + +1 Almost simultaneously, the European Commission: http://actu. +epfl.ch/news/the-human-brain-project-wins-top-european-science." +"2 “It’s essential for us to understand”: + +http://blog.ted.eom/2009/l 0/15/supercomputing. + +3 “There’s not a single neurological disease”: Kushner, p. 19. + +4 “I think we’re far from playing God”: Ibid., p. 2. + +5 “In a hundred years, I’d like”: Sally Adee, “Reverse Engineering the +Brain,” IEEE Spectrum, http://spectrum.ieee.org/biomedical/ethics/ +reverse-engineering-the-brain. + +6 “Researchers have conjectured”: + +http://www.cnn.corn/2012/03/01/tech/innovation/brain-map- + +connectome. + +“In the seventeenth century”: + +http: //www. ted. com/talks/lang/en/sebastian_seung .html . + +8 “The Allen Human Brain Atlas provides”: http://ts-si.org/ +neuroscience/29735-allen-human-brain-atlas-updates-with- +comprehensive). + +9 According to Dr. V. S. Ramachandran: TED Talks, January 2010, +http://www.ted.com. + +CHAPTER 12: THE FUTURE: MIND BEYOND MATTER + +1 5.8 percent claimed they had an out-of-body: Nelson, p. 137. + +2 “I see myself lying in bed”: Ibid., p. 140." +"2 “I see myself lying in bed”: Ibid., p. 140. + +3 Notably, temporary loss of blood: National Geographic News, April 8, +2010, http://news.nationalgeographic.eom/news/2010/04/100408- +near-death-experiences-blood-carbon-dioxide; Nelson, p. 126 + +4 Dr. Thomas Lempert, neurologist: Nelson, p. 126. + +5 The U.S. Air Force, for example: Ibid., p. 128. + +6 We once spoke at a conference: Dubai, United Arab Emirates, +November 2012. Interviewed in February 2003 for Exploration +national radio broadcast. Interviewed in October 2012 for Science + + Fantastic national radio broadcast. + +7 By 2055, $1,000 of computing power: Bloom, p. 191. + +8 For example, Bill Gates, cofounder: Sweeney, p. 298. + +9 “People who predict a very utopian future”: Carter, p. 298. + +10 He told me that the San Diego Zoo: Interview with Dr. Robert +Lanza in September 2009 for Exploration national radio broadcast. + +11 “Should we ridicule the modern seekers”: Sebastian Seung, +TEDTalks, http://www.ted.com/talks/lang/en/sebastian_seung.html ." +"12 In 2008, BBC-TV aired: http://www.bbc.co.uk/sn/tvradio/ +programmes/horizon/broadband/tx/isolation/timeline. + +13 we will be able to reverse engineer: Interview with Dr. Moravec in +November 1998 for Exploration national radio broadcast. + +14 On the other side was Eric Drexler: See a series of letter in +Chemical and Engineering News from 2003 to 2004. + +15 “I’m not planning to die”: Garreau, p. 128. + +CHAPTER 13: THE MIND AS PURE ENERGY + +1 “Wormholes, extra dimensions”: Sir Martin Rees, Our Final Hour +(New York: Perseus Books, 2003), p. 182. + +CHAPTER 14: THE ALIEN MIND + +1 So far, more than one thousand: Kepler Web Page, http://kepler. +nasa.gov. + +2 In 2013, NASA scientists announced: Ibid. + +3 how they can distinguish false messages: Interview with Dr. +Wertheimer in June 1999 for Exploration national radio broadcast. + +4 I once asked him about the giggle factor: Interview with Dr. Seth +Shostak in May 2012 for Science Fantastic national radio broadcast. + +5 He has gone on record: Ibid." +"5 He has gone on record: Ibid. + + 6 “Remember, this is the same government”: Davies, p. 22. + +7 The Greek writers: Sagan, p. 221. + +8 But St. Thomas Aquinas: Ibid. + +9 We can be fooled: Ibid. + +10 “If the fact that brutes abstract”: Ibid., p. 113. + +11 “In the blind and deaf world”: Eagleman, p. 77. + +12 we have to expand our own horizon: Interview with Dr. Paul +Davies in April 2012 for Science Fantastic national radio broadcast. + +13 “My conclusion is a startling one”: Davies, p. 159. + +14 “Although there is only a tiny probability”: Discovery News, +December 27, 2011, http://news.discovery.com/space/seti-to-scour- +the-moon-for-alien-tech-111227.htm. + +CHAPTER 15: CONCLUDING REMARKS + +1 In an article in Wired: Wired, April 2000, http://www.wired.com/ +wired/archive/8.04/joy.html. + +2 “several separate and unequal species”: Garreau, p. 139. + +3 “This techno utopia is all about”: Ibid., p. 180. + +4 “The idea that we are messin’ ”: Ibid., p. 353. + +5 “Technologies—such as gunpowder”: Ibid., p. 182." +"5 “Technologies—such as gunpowder”: Ibid., p. 182. + +6 “The you that all your friends know”: Eagleman, p. 205. + +7 “Our reality depends on what”: Ibid., p. 208. + +8 “How it is that anything so remarkable”: Pinker, p. 132. + +9 somehow create a twin of the Earth: Interview with Dr. Stephen Jay +Gould in November 1996 for Exploration national radio broadcast. + +10 “ Homo sapiens is one small twig”: Pinker, p. 133. + +11 “nothing gives life more purpose”: Pinker, “The Riddle of Knowing +You’re Here,” Time: Your Brain: A User’s Guide (Winter 2011), p. 19. + + 12 “What a perplexing masterpiece”: Eagleman, p. 224. + +APPENDIX: QUANTUM CONSCIOUSNESS? + +1 many (but not all) pathological killers: Interview with Dr. Simon +Baron-Cohen in July 2005 for Exploration national radio broadcast. + +2 Dr. Michael Sweeney concludes, “Libet’s findings”: Sweeney, p. +150. + +SUGGESTED READING + +Baker, Sherry. “Helen Mayberg.” Discover Magazine Presents the Brain. +Waukesha, WI: Kalmbach Publishing Co., Fall 2012." +"Bloom, Floyd. Best of the Brain from Scientific American: Mind, Matter, and +Tomorrow’s Brain. New York: Dana Press, 2007. + +Boleyn-Fitzgerald, Miriam. Pictures of the Mind: What the New +Neuroscience Tells Us About Who We Are. Upper Saddle River, N.J.: +Pearson Education, 2010. + +Brockman, John, ed. The Mind: Leading Scientists Explore the Brain, +Memory, Personality, and Happiness. New York: Harper Perennial, 2011. + +Calvin, William H. A Brief History of the Mind. New York: Oxford +University Press, 2004. + +Carter, Rita. Mapping the Mind. Berkeley: University of California Press, +2010 . + +Crevier, Daniel. AT. The Tumultuous History of the Search for Artificial +Intelligence. New York: Basic Books, 1993. + +Crick, Francis. The Astonishing Hypothesis: The Science Search for the Soul. +New York: Touchstone, 1994. + +Damasio, Antonio. Self Comes to Mind: Constructing the Conscious Brain. +New York: Pantheon Books, 2010." +"Davies, Paul. The Eerie Silence: Renewing Our Search for Alien Intelligence. +New York: Houghton Mifflin Harcourt, 2010. + +Dennet, Daniel C. Breaking the Spell: Religion as a Natural Phenomenon. +New York: Viking, 2006. + + -. Conscious Explained. New York: Back Bay Books, 1991. + +DeSalle, Rob, and Ian Tattersall. The Brain: Big Bangs, Behaviors, and +Beliefs. New Haven, CT: Yale University Press, 2012. + +Eagleman, David. Incognito: The Secret Lives of the Brain. New York: + +Pantheon Books, 2011. + +Fox, Douglas. “The Limits of Intelligence,” Scientific American, July 2011. + +Garreau, Joel. Radical Evolution: The Promise and Peril of Enhancing Our +Minds , Our Bodies—and What It Means to Be Human. New York: +Random House, 2005. + +Gazzaniga, Michael S. Human: The Science Behind What Makes Us Unique. +New York: HarperCollins, 2008. + +Gilbert, Daniel. Stumbling on Happiness. New York: Alfred A. Knopf, + +2006. + +Gladwell, Malcolm. Outliers: The Story of Success. New York: Back Bay +Books, 2008." +"2006. + +Gladwell, Malcolm. Outliers: The Story of Success. New York: Back Bay +Books, 2008. + +Gould, Stephen Jay. The Mismeasure of Man. New York: W. W. Norton, +1996. + +Horstman, Judith. The Scientific American Brave New Brain. San +Francisco: John Wiley and Sons, 2010. + +Kaku, Michio. Physics of the Future. New York: Doubleday, 2009. + +Kurzweil, Ray. How to Create a Mind: The Secret of Human Thought +Revealed. New York: Viking Books, 2012. + +Kushner, David. “The Man Who Builds Brains.” Discover Magazine +Presents the Brain. Waukesha, WI: Kalmbach Publishing Co., Fall 2001. + +Moravec, Hans. Mind Children: The Future of Robot and Human +Intelligence. Cambridge, MA: Harvard University Press, 1988. + +Moss, Frank. The Sorcerers and Their Apprentices: How the Digital +Magicians of the MIT Media Lab Are Creating the Innovative Technologies +That Will Transform Our Lives. New York: Crown Business, 2011. + + Nelson, Kevin. The Spiritual Doorway in the Brain. New York: Dutton, +2011." +"Nelson, Kevin. The Spiritual Doorway in the Brain. New York: Dutton, +2011. + +Nicolelis, Miguel. Beyond Boundaries: The New Neuroscience of Connecting +Brains with Machines—and How It Will Change Our Lives. New York: +Henry Holt and Co., 2011. + +Pinker, Steven. How the Mind Works. New York: W. W. Norton, 2009. + +-. The Stuff of Thought: Language as a Window into Human + +Nature. New York: Viking, 2007. + +-. “The Riddle of Knowing You’re Here.” In Your Brain: A + +User’s Guide. New York: Time Inc. Specials, 2011. + +Piore, Adam. “The Thought Helmet: The U.S. Army Wants to Train +Soldiers to Communicate Just by Thinking.” The Brain, Discover +Magazine Special, Spring 2012. + +Purves, Dale, et al., eds. Neuroscience. Sunderland, MA: Sinauer +Associates, 2001. + +Ramachandran, V. S. The Tell-Tale Brain: A Neuroscientist’s Quest for What +Makes Us Human. New York: W. W. Norton, 2011." +"Rose, Steven. The Future of the Brain: The Promise and Perils of Tomorrow’s +Neuroscience. Oxford, UK: Oxford University Press, 2005. + +Sagan, Carl. The Dragons of Eden: Speculations on the Evolution of Human +Intelligence. New York: Ballantine Books, 1977. + +Sweeney, Michael S. Brain: The Complete Mind: How It Develops, How It +Works, and How to Keep It Sharp. Washington, D.C.: National +Geographic, 2009. + +Tammet, Daniel. Bom on a Blue Day: Inside the Extraordinary Mind of an +Autistic Savant. New York: Free Press, 2006. + +Wade, Nicholas, ed. The Science Times Book of the Brain. New York: New +York Times Books, 1998. + +ILLUSTRATION CREDITS + + 1.1 Jeffrey L. Ward + +1.2 Jeffrey L. Ward + +1.3 Jeffrey L. Ward + +1.4 Jeffrey L. Ward + +1.5 AP Photo / David Duprey + +1.5a Tom Barrick, Chris Clark / Science Source + +1.6 Jeffrey L. Ward + +2.1 Jeffrey L. Ward + +2.2 Jeffrey L. Ward + +2.3 Jeffrey L. Ward + +4.1 The Laboratory of Dr. Miguel Nicolelis, Duke University + +5.1 Jeffrey L. Ward" +"4.1 The Laboratory of Dr. Miguel Nicolelis, Duke University + +5.1 Jeffrey L. Ward + +10.1 MIT Media Lab, Personal Robots Group + +10.2 MIT Media Lab, Personal Robots Group, Mikey Siegel + +A Note About the Author + +MICHIO KAKU is a professor of theoretical physics at the City College +and City University of New York; cofounder of string field theory; the +author of several widely acclaimed science books, including Hyperspace, +Beyond Einstein, Physics of the Impossible, and Physics of the Future; and +host of numerous TV specials and a national science radio show. + +Other titles by Michio Kaku available in eBook format +Parallel Worlds • 9780385514163 +Physics of the Future • 9780385530811 +Physics of the Impossible • 9780385525442 + +Visions • 9780307794772 + +Visit mkaku.org + +For more information on Doubleday books + + Visit: www.doubleday.com +Like: facebook.com/DoubledayBooks +Follow: @doubledaypub + +ALSO BY THE AUTHOR + +Physics of the Future +Physics of the Impossible +Parallel Worlds +Hyperspace +Visions" +"Physics of the Future +Physics of the Impossible +Parallel Worlds +Hyperspace +Visions + +Einstein’s Cosmos +Beyond Einstein"