Datasets:

dotan1111

/

MSA-amino-10-seq

like 0

LMLLLLLLLLEEEEDEEEEEAVAAAVAAAALMMMMMMMMMVVVVVVVVVVEEEEEEDEDEIIVVVIVVVILLLLLLLLLLFFFFFFFFFFRRRRRRRRKRSSSSASSSSSRRKRRRKKKREEEDDEDEEELLLLLLLLLLKKKKKKKKKKGGGGGGGGGGDDDDDDDDDDAAAAAAAAAAAAAAAAAAAEPPPPPPPPPPGGGGGGGGSGNNNNNNNNNNLLLLLLLLLLGGGGGGGGGGVVVVVVVVVVNNNCCNNNNCMMPLLMPMPMNNNNNNSNSNGGGGGGGGGGLLILLLIIVLYYYFYYHYYYEEEEEEEEEEMMLIVMLTLMKKRKKKRRRDSSSSSSDSSSFFFFFFFFFFPPPPPPLPEP

PPPPPPPPPPSSDTSSSSNSSSTSSSNNSSKKKKKKKKKKQQLQQQQQQQGLASSSSSLSDDDDDDDDDDDDQDDDEDDDKKKKKKKKKAQQEQNEEEQQIIVIFTIIIVAAAAAAAAAAMLLMMMMVMMVVIVIVVVAVAAASAAAAAAGAGAGGGGAGEEEEEEEEEESSTSSSSSSS-M------VM-Y------YY-R------RR-A------AA-A------AS-A------AA-W------WW-H------HH-T------QT-N------NN-H------YY-W------WW-L------LL-G------GG-E------EE-E------EE-L------LL-C------CC-E------AE--M-MMVV----L-LLLL----E-EEEE----R-RRRR----R-RRRR----V-ASAA----V-IIII----E-TEEE----V-IIII----I-IIII----L-VVVV----K-KKKN----M-MMLL------A---------N---------L---------A---------H-------V-IIII----G-GGGG----Q-QQQQ------L---------V-------A-AAAA----V-CCCC----S-SSAA----H-HHYY----E-EEEE----Y-YYYY----I-VIVV----A-AAAA----L-LLLL----I-IIII----D-DDDD----G-GGGG----R-RRRR-------AAA-------EEE------GGAG------LLLL------IVIV----T-TTTS----L-LLLA----T-MLLL--TTTTTTTATTTSATATTTATLFLLLLLLFLIIIIIIIIIIFFFFFFFFFFVVVVVIVVVVRKKKKKKKKKVLLVLLLLLLFCCCCCCCCCCLLCLLLLLLNDCNCCSSNNILFFFFFFLFEESESSSSEEQQQQQQQQQRRRPRPPRRRRMMIMIIVIMMSSASSSSSSSGGGGGGGGGGFFFMFFLLFF

KKKKKKKKKKGGTTGVGGTGEEEEVEEEEEGGGGGGGGGGAAAAAAAAAAGGGGGDGGGGDDSVDTSDSDLLLLLLLLLLTTTITITTTTKKKKKKKKKKDDDDDDDDDDIIVVIVIILICCCCCCCCCCVVTGVGVVVVNQRRQRRQRQLLVVLVLLLLTTTTTTTTTAAAAAVSAAAAGGGGGGGGGGNNHPNANNNNKQTTRYTQPQEEQQEQQEQESQQQQQQQQSLLILLLLLLLAAAAAAAAAACCVVNVVCVRTASSQASSSTAAAAAAAAAAFQQQFQMQQFSSSSSSSSSSHHHHHHHHHHAVVVVVVVVV----L---------E---------S-----TLLLTLLLLQWWWWWWWWWWK---Q----K

EEEEEEEEEEFFFFFFFFFFAVVAAVVAAAPPPPPPPPPPYYYYYYYYYYGGGGGGGGGGILLMIILIIIIIIIIIIIVISQSSTSSSTSEEAEEEEEEEVASVASAAAVTSSTTSSTTTFYYYYYYYYYEEDEEEEEEELVVLLVILLLEEEQEEEEEEKKKKKKKKKKSSSSSSSSSSGGGGGGGGGGQKQQQQKQQQKRKKRRRRRRLFLLLLFLLLEEEEEEEEEEDNDDDDNDDDRRQRHRKRHRVIVVLIIVVVLLLQLLLLLLEEEEEEEEEEERRRRRRRNKTVTTTTVTTQGGGGGGGGGGGGGGGGGGGGWWWWWWWWWWDDDDDDDDDDIIIIIIIIVIIVIIIIIILLSSGSNSSSNSDDDDDDDDDDKKKKQKKKKENNNNNDNHNN-VV--VV----FF--FF---

MMMYYMYMMMQQQQKDQQQDFLLFFLLLILEEEEEEEEEETTTTTNTTENYYYYYYYYYYAAMAAMAAAIHHHWHHHH-HAASAASAA-SIIIIIIIL-LIIIIIIII-IVIIVVIVVIIKRKESKKKKKAAASSAAAAA--------S-TRRRRRRRRRLLLLLLLILLTTITTITTIISSSRSSSSSTNNDNNDNNNDLLLVVLLL-LAAAARAAA-ASSRSSRSS-RESERKEEE-EFFFMMFWF-LRRRSSRSTRRIIIVVVVILIIIIIIIIIIIASGSSGASNGTSSTTSTTASSSASSASSAASSASS-SSS-RRRRRRRRRRIIIIIIIIIIIVVVVKVVVKRRRRRNRKKRSSSQQSQSVS--H--H---H--E--E---E--Q--Q---QSSVSSASSSASSTTTTTSTT

DDDNDDDDDDIIIIIIIVIVQRQRQRRQQQAAATAAASASIIIIIIIIIILFLFLFFLLVGGGGGGGGGGWWWWWWWYWY-L-L-LL----K-K-KK----N-N-NN---IHIHIHHVIVYQEQEQQQEQRSRRRSERRRQHKHKHHKQKNHQQQHQQQQNSNSNSSNNNVLVMVLMMVMKKKKKKKKKK--V-V-------S-S-----GYMMMMLMMFIIIVIIIIIILLLLLLLLLLSNSSSNSSSSD-D-D--DDDIIIIIILVIIMMMMMMMMMMYYYYCYYYYYAASVSAAAAALMLLVLLLLLVVAVQVVVAVHQHQHEHRHHDDDDDDDDDDEDEDEDDEEE---------V---------N---------G---------M---------K---------R---------F---------S---------P---------Q---------Y---------I---------D---------G---------E---------T---------R---------N---------L---------NGSSS-ASSGSLILI-AHLLLIIII-IIVIIGGGGGGGGGGSA-S-NNSSSQQ-Q-QQQQQRN-N-NNRRR

SSSSSSSSSEILLLTLLLKLCCCCCCCCCCAAAMAAAMAIDDDDDDDDDDKKKKAKKKAKGGGGGGGGGGFFIFFFFYFILLFLMLLLILKKKKEKKKEKGGGGGGGGGGMLMVIMMTIMHHHHHHHHHHLALAALLAALVTVTTVVTTV---C---C--FFFFFFFFFFVQQRQVVQQQYYYYYYYYYYKKKKKKKKKKV-V--VV--VE-E--EE--EDDDDDDDDDDKKKKKKKKKKKKKKQKKKQKEEEEEEEEEELLLLMLLLLMKRRRLRKRRRNNNHNNNNNNLLLLLLLLLLSSSSSSSSSSAKKKKKAKKKGGGGGGGGGGLLLLLLLLLLPPPKPPPPPPRHRHRRRRRRNNNNNNNNNNVLLLLLLLLLASSSSAASSSGGGAGGVGGGFFFFFFFFFF------K---IIIIIIIVII

AAAAAAAAASSDSNSSSSDNLLSMSSSLLAGGGGGGGGGG-----V---------S---------S---------F---------N---------T---------S---------V---------K---------N---------V---------D---------Y---------A---------K---------P---------Q---------K---------Y---------D---------P---------E---------E---------M---------L---------F----VVVIVVVVVVDHDDDDDDHDLLLLLLLLLL--G-GGG---IKIIIIIIKKQ-QQQQQG--E-DDDDDD--R-RRRRRR--Y-YYYYYY--SSASSATSSSQQQQQQQQQQSTRSTTPSSSYYYYYYYYYYSSSSSSSSSSMMLMMMMMMMFFAFAAAFFANNSNNNNNNNFFFFFFFFFFKKKKKKKKKKKAGAQAQAAADDDDDNDDDDPPPPPPPPPPYYYYYYYYYYEEEEEEEEEEIIIIIILIIIKSASAAAKSSLIQLILLLII-IIIIIIIII-AAAAAAAAA-FFFFIFFFF-IAIIIIIII-PPPPPPPPP-EEEEEEEEE-RKRKKKRRR-LLLCLCLLLKKKKT-KKKK

DDDDDDDDDEIIVIIVIIII---E---E--PPPPPPPPPPFLFFFFFFFFKKNNKNKNKKTTVTTTTTTVQQ----Q-QQLL----H-LLAA----A-AALL----W-LWLLILILLLLLIYIVIVVVFIEEEEEEEEEENNCCCCKCKNNNNNNSNNNNAAAAAAAAAATTTTTTTTTTRRRRRRRRRRLLLLMLLLLLHHRRHRHRHHSSSSSSSSSSIVMIIIVIVVMMLLMLMLMMNNNNNNNNNNLLIIIILILLTTVATAIATILLLLVLLLLMNGGGGGNGGNYYLLHLYLYYAAAAAAAAAAGGGGGRGGGGA-AAAAAAAAF-FFSFFFFF--E-------P-PVPPPPPPS-STSSSTSATTGSGGTSTTDSSASSDSTDVVVVVIVVVVGGGGGGGGGGKKRRRRKRKKSSQSSSTSSTMMSGSDMGMMNNNNNDNNNN----A---------D---------V---------A---------I---------E---------S---------L---------H---------E---------S---------L---------Q---------E---------Y---------A---------R---------N---------N---------V---------E---------P---------T---------A---------D---------L-----

DDDDDDDDDDVVMVMVMVVVLLLLLLLILLIIILIIVIIIQQQQQQQQQQRRRRRRRNNRVVVVVVVVVVCCCCCCCCCSAAAAAVAAAAGGGGGGGGGGKKKKKKKKKKLPLLLLLLLLQQQQKQQQQQEEEEEEEEEETTTKTTTTTTFFFFFFFFFFGGGGGGGGGGKKRKRKRRRK--E-E-EDD---I-I-IIV---V-V-VII---F-F-FFF-RRRRRRRRRRFFFFFFFFFFKKKKKKKKKKSSSSSSSSSGIIIIIIIIIIQQQTQQQQQQTTTTTTTTTTFFMFMMMMMMLFVLFLIIILDDDDDDDDDDFLFLFFFYYFVISITASARA

LLLLALLLLLLHLILLLLLHNNNNNNNNNNLLILLLLLCLEEEEEEEEEETTTITITTSTEEEELEEEEELLLLLLLLLVTTTTTTTTTTVFVVVVVVFFRRRRRRRRRRIFLIIILIMFVVVVVVVVVVATTTTTTTTTFFFFFFFIFFSVSSSSSNSVKKKRKRKKQKVVVVIAVIVVKKKKKKKKKKRQRRRRRRRRAAAAAAAASANNNNNNNNNNMLLLLLLLLLFFFFFFFFYFGGGGGGGGGGTKKTTTKTKKEEEEEEEGEENVNNNNNNVVRRRGGGRRRRTTTTTTTTTTAIIAAALILIKVEKKKEEEV-EE---E-EE-II---I-II

VIVVIVVITIDDSSASDSDSFFFFFFFFFFYYYWYYYWYYAAAAAVAAAA-----Y---------L----DDDDDDDDDDLLLLILLLLFSAVAAVAAAAILLLLLSIALCCCCSCCCCCKKKKKKKKKKFFFFFFFFFFVVLYILIIIIVVPPPPIPIPAASAAGAEAARRRRRRRRRRFFPPPPPPPPFILKILVIIIAAAAAAAAAARRRRRRARRRTTTTLTTTTVQQQQQQQQQQGGGGGGGGGGVVVVVVVVVVAAGAAGAAAAAASSPGPSASIIIVIIIVIIDENNNNNNNNNNNNNHNNNNAAAAAAAAAAPIPPPPPPPPVVVVVVVVIVQQRQQRQQTQEEEEEEEEGEVVVVVVAITV

TNTTTTKKTSIIIMVIIVVIDDDNNDNNNDPPPPPPPPAPGNTTMTTTTTAAAAAAAAAQLLLLLLLLLLPPPPPPLAPPVVVVLIVVIVSASASSAASADDDDDDDDDDDAGDDGDDNA----S---S-----L---L-----G---G-LLLLLLLLLLIIVIIILLIITTPTTTTTTTRRTKKTKKTRMLMLLMLLLLDEDDDDDDDENNNNNNNNNDQTEQQEQQSTVVVVVVVVLVDDDDDDDDDDMLMMMIMMMM--R---------R---------P---------S-------FIFFFFFMFIILIIIIIIILNNNNNNNNNNASSSSSSSSSGGNGGGGGGGTTTVVTTTVTGGGASAAAAGPPPPPPPPPPTTTTTVTQTTNNNNSNNNNTVVVVVVVVVVIIIIIIIIIISASAAAAAAANNNEENDDENTTTTTTTTTTEEEEEEEEEE

LLLLLLLLLLGGGGGGGGGGKKKKHKKKKKPPPPPPPVPPGGGGGGGGGGVVVVVVLLLVFYYNYNDDDR------K---------T---SCASSSSSSTLLLLILFLLLLLLLLLLLLLPPPPPPPPPPIIIILVIIILFFFFFFFFFFFFFVFFFFFFEEEEEEEEEENNNNNNNNNNQRRDQDRRRQPPPPPPPPPPTTTNITTTTIKKKKKKQQQKSSSSSSSSSAPP-PPPPPPPCC-CCAACCCLI-LLLILLLII-IIIVVIIIIIITIIIITGGGGGGGGGGDDDDQDDDDDIIIIIIIIIILWWLILLLLIVVVVVVIIIVDDDDDDDDDDLLHLLLLLLLDDDDDDDDDD

TTQTSTSTAA------L-L-------S-S-------L-L-------T-T-------Y-Y-------E-E-------P-P-------G-A-------L-L-------V-V-------T-T-------A---------Y-Y-------K-K-------N-N-------A-A-------A-A-------Y-Y-------F-F-------P-P-------T-T-------P-P-------L-L-------S-S-------K-K-------Y-F-------D-D-------F-F-------L-L-------P-P-FFFYFFHFHFILIIVIVIVIWWWWWWWWWWLLLLLLLLLLIIIIIIIIIYAAAAPAPAPAHDHHHHDHHHIIIIIIIIIISSSSSSSGASSSSSSSSSSSL---------A---------AASAAAAAAARRLRRRRRRRRRRRLRARLRRRRRMVARAAQEQEHEFQHHLLLLLLLLLIRRRRRRRRRRILLLILLLLL-RKR-R-K---DDE-E-D---MLM-M-M---MII-I-I--VVVVVIMVMV---S------VVIALVMIMMTTLTTVTTTTTSSSTSTSTTRRRRRRRRRRWWWWWWWWWWKKKQAQAKAKDDDDDDDDDDY---H-H-HHGGGGGGGGGGAAAAAAAAAA

VVVVVVVVIVAAASAYSSAYTAATTTTTAS-------S--EEEEEEEEEEPPPPPPHPPPRRRRRRRRRRVVVVVVVIVIKKKKKKKKKKTVVTTATTVATTTTNKTTTKVVVVVVVVVVAAAACCAASCPPPGPPPPPPFFFFFFLFFFEEEKEEKKEESADSSRSSARDDDDDDDDDDTVVSKKTTVKKKKEKKMKKKGGGGGGGGGGPPPPPPPPPPKKRQKKKQKK-G---------G---------T---------P--------RRRRRRHRRRTTTTTTTTTKNNNSNNSNNHLVVLVVLLVVVTTATTAATTAAATAATSAASSTESSTTNSSSSGSNSTSNLLVLLLLLLLVVVTVIVTVIPPPPPPPPPPAGGGAAAGGADNEDDDDE-DMMMMMMMM-PFGGGGGGG-GIIIIIIII-ISSSSTSSSSS

AAAAAAAAAANDNDNNNNKRSSSSSSSSSSLLLLLLLLLLLILLLLTLLLAAAAASRAATEAAAAAAAAALEQEQLEEEEEEEEEEEEEEC-C-CCC-CCK-K-KKK-KKNNNNNNRNNNPPPPPPPPPPEEEEEEEEEEIIIIIIIIIIDDDDDDDDDDEHEHEEEQQQQQQQQQQNQQGDGDGGGDGGKKKKKKKKKKYFYFYYYFFYDDDDDDDDDDMMMMMMLMMMVVVVVVVMVVRQRQRRRQQQLLLILLLLLLYYFYYYFYYYNNNNNSNNNNLLLLLLLLLLQEEEEDEEEEKKKSKKKKKLDDDDDDDDDDNEDEDNDDDDGGGGGGGGGGHNHNHWHYHHFFFFFFFFFYNNNDNNNNDN

KKKRKKKKKKSSNNNNNNNNQQQQQNNQNQAAAAKAAAAAGGGGGGGGGGMMMMMMMLMMDDDDDDEDEDPPPPPPPPPPILITTTIIVIGGGGGGGGGGSSSSSSSSSSEEEEEEQEDENNNNNNNNNNPPPPPPPPPPVLVMMMLLLVDDDDDDDDDDAAHAAAAAAAYYYYYYYYYYHHHHHHHHHHPPPPPPPMPPPPPPPPPPPPVVVVVVVVVVGGGGGGGGGGDDDDDDDEGDACACCCCCCVYYYYYYYYYYNNNQQQNQNNLLLLLLLLLLSKSEEEEEEEAAATTTATAALLLLLLLLLLEEEDDDEDEE

IILIIVILIITDTTKKKTTTEEDEEEEDEERRRRRRRRRRRRRRLRKRRRVVTVPPPTVKYYYYYYYYYYKKKKKKKKKKKQQQHQQQQQMVIAIIIIVMQQQQQQQQQQPPPPPPPPPPQQQQQQQQQQAAAASASAAAEEKEEEEEEENN-NNNN-NNDD--DDD-DDLL-LLLL-LLRR-LRRR-RRLL-LLLL-LLSS-SSAS-SSVV-VVVV-VVDD-DDDD-DS----PPP-------EDE---WW-WQQQ-WWLL-LLLL-LLYF-FFF--FFDD-DEDE-DELF-LLLL-LLTT-TTVT-TNLL-LRKR-LL

EQEEEEEEEEIIIIVIVIIIRRRRRRRRRQTAVAVVVVAVAAAAAAAAAALLLLLLLLLLLLLLLLFLLLLLLLLLILLLT--T----T-L--F----L-F--Y----Y-Y--Y----Y-T--V----T-AAAAAAASAALLLLMLMMLLLLLLLLLLLLLLLLLLLLLLDDDDEEEEDDFYFFFFFFFFCCCCKCMCCCHHCHCCCCHCTTTTTTTTTTPPPPPPPPPPQQQRRQRQQQPPEPEEEEPPPPPPPPPPPPIIIIEIFIIIIIIIVIIVIISSSSSSSYSSEEEEEEEEEERRRRRKRKRREEEEEEEEEDKKKKKKKKKKSSSGSSSSGSTRETEEEETETSSTSSSSTSVVVVVVVVVV

RRRRRRKRRRSSTSSTSSSSPPPPPPPPPPAVVLVVVVVVDDDDDDDDDDGGGGGGGGGGATTTVTVVVVVIIIVVIVLVPPPPHPHRHPEEEEEEEEEEDDDDSDSSSDVVVVVIVVAVAAASAAAAAATTTTSTTNATLLLLLLLMLLDDDDEDDEDDHHHHHHHHHHYYYYYYYYYY-GGRGGGGG--VVVVVVVV--QQQQQKEQ--AVAEVEEE--FFFIFYFF--LLLLLLLL--SSSKSKKK--HHHHHYHH--PPPPPPPP--KNNNNNNN--IAVTVLTI--QQQSQSSS--SSSAPAAA--QKKQKQEQ-

HHDHHDDHDDHHHHHHHHHHQLQLLLLELLPNEEDEDPEDMMILMIMMMQSSTTSTQSVTIIIIIIIIVIGGGGGGGGGGIIYYIFIIYFGGGGGGGGGGIIIIIIIIIILLLLLLLILIDDDEDDDDEDVILIILIVIITIITIIIITIPPPPPPPPPPAGGGGGGGGGFFFFFFFFFFQQQRQQQQRQKKRRKRKKKKTTTCTTTACTFL--L-LL-LIIIIIIIIIIGGGGGGGGGGCVVIVVVCVVRRRTKRRRRQQLLLLLLQLLHHNRHNHHRHCVVIVVVVIVEEQEEEEEDEFFYYFRMFYYDNDDDDNDDELLLLLILLLLRKRRRRRRRCEEEEEEEEEEHHHHHHHYHHYYYYYYYYYYIIIIIIIIIISSVVQVTSVT

SSSSSSFASSHHSHRHRYRHQQQQQQQQKQIIVIVVVIVIYYYYYYYRYRLLLLLFLLLLREEKEEEDEDPPPPPPPPPPQLLQLLLLLLGGNGNNNGNGWWWWFWWWFWDDDDDDDEDEEEEEEEEEEEIIIIIIIIIIRRRRRRRRRREEEEEEEEREVIIVLIIILIEEEEEDQEEETTTTSTSTSTAAAAAAAAAAKQKKEKKKKKVVAVAAAVALYYYYYYYYLY-------E---------E---------D---------D---------A--NKNNNNNKNKFIFFHFFIFIYYYYFYYHLHKKKKKEKKKKLFLLLLLILLPPPPPPPPPRKKKAKKKKKKAATATTTETAVVVVVVVVVV

HQHQQHQNNNSASTAHTHHQEEEEEEEEEEQQQQQQQQQQIIVIIIIIIILFLFFFFFFFHTHTTQTQQIVVVVVVVVVVVIVIIVLVVVDEEEEEEEEEGGGGGGGGGGLLLLLLLLLL------Q---TTTSTTTTTTVLLLLLLLLLNENEEEEEEERRRKRRKRRREEEEEAEAAATVTTVTTTTTEEEGEEEEEENDNSDNDNNNLLLLLLLLLLAAAPAAPAAAHAHASTATTTDDDDDDDDDDDDDDDDDDDDMMMQMMQMMMQQQQQQQQQQVIVIIVIVVAVVVVVVVVLVIMIMMMMMMMTTTTNATAAAMTMMTMMMLLKRKRRSRKKKKKKKKKKKKKQQQQQQQQQQLLLYFLFLLLKKKKGKKKRKAAPAAAAAAA-------S---------D---------L---------W---------R---------V---------I---------W---------F--

LILIILKLKLFFFFFFFFLFQQQQQQQSQQLLLLLLLLLLKKKKKKKKKKLYFYYLYYYFAAAAVAASAALLLLLLLLSLTTAVTTTTTTLLLLLLLLLLEEEEEEEEEEMPQPSLMMVQQQQQQQQQQQITVTAIIIIVEEEEEEEEEEM-I-IIIIIIRQRQQRRRQRNDDDDDDDDDVAVAAVAAAVDEDEEDDEDNTTTTTATTTTSACAACCAC-AATAAAAAP-FFFFFFFFF-TTTATTTVA-YYYTYYRYA-LLVILLLLL-VVVVVVVVV-QRQRRQRRR-PPNPPPPPP-VAAAAVSAA-FYFFFFLFY-

SVTVVTVVVTYYYFFYYYYYVNNNNNNNNNSDSDDSDDDTAAAAAAGAAAEEEEEEEEEEMTMSTMTTTMKKKKKKKKKKGGGGGGGGSGPPPPPPPPPPRRRRRRRRRRRHRRRRRRRRKKKKKKKKKKFYIFFFFFFFFFFFFFFFFFSTSTTSTTTSYFYYYYYYYYFFFFFLFFFLGGGGGGGGGGEGGGGGGGGGESDEEEEEEESSSSSSSSSSEAEAAAAAAATATTTTAATTYYYYYYHHYYKKKKRSPPKSPPPPPPPPPPTSSSSSGGSPQEEEEEDEEERNRNNRNNNRSKSKKKKKKKATALAATTAA

-V---------N---------K---------F---------P---------Y---------E---------A---------T---------S---------P---------A---------G---------N---------F---------L---------A---------E---------T---------N---------L---------Q--------RRRRRRRKRREEEEEEEEEE---------K---------DLLILLLLLLLVLIVVVVVVVYYYYYYYYYY---------EAPPAAAAAAPINVIIVIIIIGSGGGGGGGTTTVTTTTTSTLIFLLLLLLIIIVIVVLIVIRTQHHHLQHQFMMFFFFFFMSSSAAASSAS----H---H-AKKAAAKSAKPPPPPPPPPPMLQMMMMMMLDDDDDDDDDDGAAGGGAGGAQASQQQQQQSLLLLLLMLLLNNNNNNNNNNRRRRKRRRKRYYYYYYYYYYLFLLLLLLLFDEEDDDEEDEEEEEEEEEEESSSSSSSASSTTTTTTTTTTMMMMMMMLMMRRKRRRRRRRAGGGGGGGGGLLLLILLLILTSTTTTTTTSNNNNDNNNNNKTTMMMTTMTPPPPPPPPPPEDDDDDDDDDCDDDDDDDDDQQQQQQQQQQVAAVVVVVVACCCCAACCAC

NNNNDDDNNNDDDDSSSDDSKKKKKKKKKKNNNNNHNVNNVVVVVVVVVVYYYYYYYYYYRRRRRRRRHRAAVAGAAAAASSSAIVVSAVAAAAASAAAAQKQKKKKQKK----S---------K---------F-----STTTKATTTKLLLLLLLLLLVTVTTTTVTTGGGGGGGGGGEEEEEEEEEESSSSSSSSSSDDDDDDDDDDLLLLLLLLLLAAAASAARASPPPPPPPPPPAQAAAAAAAAKKKQHHHKQHPPPPPPP-PPTMTMMMM-MMSSSSSSS-SSEEEEEKK-EDIIIMILL-IIRRRRRNN-RREEEEEEE-EEHHHSHHH-SHKKKHKKK-KK

AAAASSMAAAAASAAAAASSLLILVVLVIIPPPPPPPPPPAAHAAAAAHHVLLVVVVVLLMMMMNNMNMMVIIVVVIVVIRRQRTRRRQQEEEENKEKEEVAAIVVAVAARPPRRRKRPPGGTGGGGGGGQQQQ--Q-QQSPPS--P-PPSSSS--T-SSEEEE--E-QQGGGG--G-GAEEAE--E-AATTTT--T-TTAEEA--E-EERRRR--R-RKLLLL--L-LLYYYY--Y-YYQPPT--T-PPVVVV--V-IVEEEE--E-KKGGGG--G-GGVVVV--V-VMIILI--I-IIIIII--I-IIDDDD--D-DDVIIV--M-LIS--S------VVVV--V-VVCCCC--C-CCTLIT--I-IIGGGG--G-GGRRRK--R-RRPPPP--P-PPQQQQ--Q-QQHRRR--R-RRLLLL--L-LLFFLF--F-LLIIIV--I-VVYYYY--Y-YYDEED--E-EEGKKG--K-KKLLLL--L-LLLFFL--F-FFLLLLLLLLLLSSTSSSSTSSKKKKKKKKKKRRRRRRRRRRYYGYNNYNGG----VV-V------II-I------MM-M------GG-G--HHHHQHHYHHYFYFLLFLYYYYYYYYYYYYYYYYYYYYYYQQQQNTQNQQFFFFFFFFFFKEEKEEEEEEAEAAAAAAAAKKKKEKKKQKRRKRKKKKKKPPPPPPPPPPGNNGNNNNNNGGGGEEGGGG----VV--------IL--------EE--------KK--------IL--------RR--------EE--------FF--------LL----GAGPLLAMVADDDDAADADDTTTTNTTTTT

AAAAAAAAAAYYYYYYYYYYEEEEEEKETELILLILLILLKNQQNKKNKNRHRRHRRHRRRIIIIRRIIIEEPPAEEEEELLIILLLLIIVVVVVVVVVVMMMMMMMMMMEEEEEEEEEEPPPPPPPPPPLIIIILLILLGGGGGYGGGGEQQQQEEQEETTDGNTTTTTIIIIIIIIIIWWAPWFWWWWFFFFFFFFFFVKRRKKRRRR---------R---------D---------V---------F---------H---------P---------A---------R---------G---------I---------M---------V---------E---------D---------E---------T---------T---------E---------I---------L---------S---------Y---------E---------P---------W---------N---------K---------E---------G---------K---------I---------P---------L---------A---------P---------LKVSNVKKKKKRRLKNRRRRRV---------I---------I---------A---------N---------H---------Q---------G---------L---------LLLLLLLLLLYYYFYYYYYYYYYYYYYYYYEEEEEEEEEEYYFFYYYYYYILMILLVIVIQQVVQQHQQQHHHHHHHHHHGRRRRGGRGRLLLLLMMLLLVV--VVIVVVDD--DDDDDDEE--EEDEEEKT--TTSTSSLLLLLLLLLA

EEEEEEEEEEFFFFFFFFFFIVVVVAVVVAMMMMMLLLMLTNNKKNNNNSDDDDDDDDDDMALMMQAAAQFFFFFFFFFFEEEEEDEEEESTTTTSTTTSVIIIIIIIILFYYYYYYYYYFFFFFFFFFFAASAACCCACYYNYYYYFYYNSNNNEEESEGSSSSSSSSSKKKKKKEKKKTTTTTTTTGTTTTTTTSSTTSSSSSNSSSPLLLLLLLLLLQQQQQLLLQLIIIIIIIIIILLNLLLILLLSSSSSRSSNRVLVVLAVVVVLMMVLMMMMMGGGGGGGGGGMTMMMMMMTMVVVVVLLLVLIIIIIVIIIIKKKKKRKKKREEEEEEQKEESSSSSAAASTGGGGGGGGGGEEEEEEEDEEITTTTPPPTPIIIIIIIIIILLLLLLLLLLVVVVVVVVVV

DENDDDDEDDFFFFFFFFFFLLLLLLILLLVVGVVVVVVVFYFFFFFYFFVVVVVVVVVVYPYPYYPPYFDDDDEDDDEDQNQNQQQNQQRRRRRRRRRRYYYYYYYYYYCCACCCCCCAIIIIIIIIIVDEDEDDEEDNYNSNGNNTNS--L------L--A------A--S------S--A------A--P------P--A------G--G------P--C------C--S------S--L------L--L------L--K------K--Q------Q--P------P--M------M--L------I--L------L--R------G--E------E--L------L--F------F--S------S--C------C--K------K--V------V--T------T--T------T--V------V--S------S--W------L--S------S--Q------Q--F------F--A------A--G------G--P------P--H------H--S------S--D------D--E------E--L------L--L------LAN-SSASNS-EE-EENEEE-CSESACSSAERRRRHRRRHRIIIIIIIIMILVLVLLLVLLTGGGGGGGGGATTTTAATTTAVSVAAGVASFYFYFFFYFFEEEEEEEEEEAAAAASAAAATTSTTTTTTSLLRLLLLILRIIIIIVIIIIKKKKKKKKKKAQEEEAEEEENNNQNNNNNNIVIIIIIVIILLVLLLLLIVKSKRKKKSKKSAETASSAAEFFFFFFFFFFR-RKRRR-RRN-SNNNN-HSS-VDSSS-SV

SSGSGGGGSSCIIIIIIICCDDDDDDDDDDPPSPDSPPPPLLVLVVIILLVVVVVVVVVVKKKKKKKKKKGGGGGGGGGGCCLCLLLLCCLLFLFFYYLLVVVVVVLLVVDDEDEDDDDDEKKKRKKKKKQLLLLLLLQQAAAAAAAAGAMLMLLLLLMMGGGGGGGGGGGGGGGGGGGGEEEEEEEEEESSSTSSSSSSEEEEEEEEEEIHEHHHHHHISSSSAGAASSPPPPPPPPPPSSPSPAAAFSDDDHDDDDDDVVVVVVVVVVYYYYYYYYWYGAAAAAAASSTSSSSSSSSTYYFYFYYYYYEDDDDDDDEETTTTTTTTTTNQSQNNNDNNQQNQNRQQQQLLLLLLLLLL

RQQRRRRRQRKAKGKAKGAKEDEDEDEDDETCSSSSSSSSDDDDKDDDDDPPPPPPPPPPSTSSSTSSTSEEEEEEEEEELLLSLLLSLLLLLVLLLVLLPPPPPPPPPPGGGGGGGGGGTNTTTSTTSTVVVVVVVVVVEEEEEEEEGEAAAAAAAAAAEEEEEEDEEEHQHHHHHHQHGASSSASSASQEQEEEEEEDKYKKKKKKYRASASSSSSSSSKTKTKTKKTNKNKNNNKKKHYYFYYYYYYATATTTATTTLLLIMLLVLLTTTTTTTTVTDEDEEEDEEETTTTTLTTTTPPPPPPPPPPVVVVVVVVVVLFLLLFLLFLLLLLLVLLLL

TCTCTSTTTTRRRRRRRLRRASASASAVSATTTTTTVTTTDDDDDDDDEDLLLLLLVLLVPPPPPPPPPPPPPPYPPPPPPEPEPEPEEPIIIVV-IILIAAAAA-AAAAGGGGD-GGNDRRRRR-RRRRVFVFV-VLLVGGGGG-GGGGTPTPS-TSPTGGGGG-GGGGVAVAV-VVAVNDNDN-NNDNILVLL-ILLLEDEDE-EEETFHYHY-FHHYVVVVI-VVVIILILL-ILLLEKERK-EKKKLLLLL-LLLLTTTTA-TTTTSPPPP-SPPPCICIC-CFFCGAGGG-GGGGDDSDD-DEDDKKKKK-KRKKMAMAL-MMAMVAVVV-VTAVKKKKK-KKKKDEDED-DEE-HNHNN-HNK-KRKRK-KKR-FFFFF-FFF-DGDGD-DDD-KKKKK-RYKK

PPPPPPPPPPVVVAAAVAKAAAAAAAAAAAAGAHGGGGGGSSTSSSSSSSALLLLLLLLLTTTSTESRKKSSSSSPSSPSSSSSSSSSSSCCALLCCCCCWAWWWWAWWWGGGAATGGTGKEQKKKEKKKKNKNNNNVNNIMILLLVLLLLLLLLLLVLLKKKVVAKAAAGSRGGGSGGGHHHFYYHYYYWWWWWQWQQQ-----A--AQ-----M--MM-----M--MM-----P--PPFFFEFFFFFFVVVVVVIVVV-----L--L---------I---------V---------G---------V---------L---------G---------Y---------R---------A---------E---------I---------V---------L---------F---------Y---------S---------G---------Q---------C---------P---------V---------I---------E---------N---------P---------T---------K---------F---------R---------T---------P---------G---------D---------E---------K---------D------R--R------K--R------P--P------A--A------Y--Y------L--L------V--V------V--M-GGGAAGGGGGKKKSSEKEEERRRGGGRGGGKKNKKAKKAANTNTTATAAAKKKKKKKKKKRRRRRRRRRRPSSSSSSSSSTTTTTTTTTTPPPPPPPPPPPPPPPGPPPPLLLLLLLLLL

AAAVAAVVVASFSFSSFFFFFFLFLFFFFFSSSSAMHHHSNNNNNNNNNNDDDDDDDDDDTASASAAAAAILILIILLLLEEEEEEEEEEVLLLLLLLLIDDDDDDDDDDVVLVLEVVIVCSTSSSSSSSLLLLLLLLLLRKRRRKQRSRVIVIVVTITVGGGGGGGGGGEEEEEEEEDEQQQQQQQQQQDDD-DDDDDDNNN-NNNNNNLQL-LLLLLLSDS-SKEDEDNKN-NEQKEKHEQ-QHHHHH-I---------R---------D---------D---------K---------A---------L---------Q---------G---------M---------I--------III-VILILIAAA-AAAAAAAAA-AAAAAACCC-CFAAACRQR-RQQQQQEDE-EEDDDDSTG-GTSSSEPPP-PPPPPPESE-EEASSSVAV-VVEEEAKKK-KKEEESQKK-KKRKEKDDD-DDDADDEGD-DDGGGGKKK-KKKKKKTSA-ASTSSS

KKKNQKKRRRKKKQKKKKKKLLLLLLLLLLST-TTN-STTQM-QMM-AMIVI-VVI-VVVPQ-PPP-PPPIL-ILL-ILMLP-LLL-LLLKS-KKH-RKKAL-ALL-ALLFF-FFL-LFFTT-TTT-PTTYY-YLY-YNYAV-AVV-VVVTE-TTS-TTTVV-IIV-IIVKE-EEE-EEEVV-VVV-VVVQQ-QQQ-EQQAA-ADA-ASAII-IIL-IIIYY-YLY-YLLTT-TNT-TNTWW-WWW-WWWGG-GGG-GGGGG-GGG-GGGDD--DD-DDDKK--KK-KKKPP--PP-PPPEE--EE-EEEKQ-KEE-KEEEE-EKE-EEEIV-IVV-I-VFF-FFF-C-SPP-PTP-P-P

IIIVIVIVIVLLLLLMLLLLGGGGGGGGGGLMLLLLILLLGGGGGGGGGGVVVVVTVVVI--D---D-----V---V-----D---D-----N---N-----Q---H-----K---K-----S---S-----L---L-----H---H---EEEEEEEEEEQEQQQQQQEKNFFFFFGFFFWWWWWWWWWWEEQDQDQDQDQERQQNKQQN--D-D-D-----N-N-N-----L-L-L-----F-F-F---LLVLLLMLLLEEDEDEDEDESSSSSSSSSSPPPPSPPPPPFFFFFFFFFFVVVVVVVIVVGGGGGGGGGGGGGGGGGGGGVVVIVVVVVVYYYYYYYYYYIIIIFIIIILIIIIIVIIIVGGGVGGGGGGAAVDTDVDTDRRRRRRRRRKPPPPPPPPRPDDDDDDDDDTGGGGGGGGSGKQEMEMEMQMYYYYYYYYYYKKKEKKQKNKLLVLVLVLIL

EEEETDEDDECCCCCCLVCCAAALLLGALAATTLTVPTTALLIIIILLILKKKKKKHKKKGGGGGGGGGGSTSSSSESSELLLLLLLLLLPPPPPPPPPPNNNNNNNNNTTTTTTTHATHHHNHHHHHHHEDDDDDEQDEPPPPPPSPPSFMMMVVFMMFLLLLLLLLLLRRRRRRRRRRAAAAAAAAAATSSTTTTTTTVVVVVVVVIVFFYYYYFFYFEEEEEEEEEEVVVVVVLVVLKKKKKKKKKKDLDDDDDDDDVVVVIVVVVVLVVVVVTIVIRRRRRRRRRRDEEEEEEEEEFFIFFFFFFFEEEDDEEEEEAAASSTAASAEEEEEKEEEE

FFFFFFFFFFTAEEEENEETTS-S-SS-STTK-T-KT-TTIV-I-VV-VISP-S-PS-SSDE-G-ED-GDHH-H-HH-HHSS-S-SS-SSVV-V-LV-VVFF-F-FI-FFTT-T-TT-TVVH-C-CL-CIII-I-II-IILL-L-LL-LLSS-S-SS-SSKE-H-QK-HKDD-D-DD-DDLL-Y-LL-YLPP-P-PP-PPSA-S-SS-SSKK-K-KK-KKTA-T-TT-TTPP-P-PP-PPRK-K-KK-KKGA-A-TA-AGNN-D-NN-DNSA-A-AA-AQLL-L-LL-LLAA-A-AA-AAII-I-II-IINNGNTNNNANFFFFFFFFFF

EEEEEDEEEEAAAAAAAAAATTTTTTTTTTLLLLLLILLLAAAAAAAAAALFLLLLLLLLPPPPSPPPPPQQQQQQQQQQVVVVVVVIVVPSSSSPSPSSEASEQEEEEQKVVVVTVVVV---PP----PVIIIIVIVIIKKKKKKKKKKVVVVVVVVVVNNNFHNNNDHTAATTTATATQQQTTQQGQTRKKKKKKKKKEEEEEEEEEENTTTTSTTTTYGGGGYGYGGMMMMMMMMMMEEEEEEEEEEPPPPPPPAPPDDDDEDQDDD-FFYY-F-FYRRRRRRRRRRLLLLLLLLLLEEEEEEEEEEKGGGGKGKGGAAAAAAAAAAVKKKKVKVKK

LLLLLLKLLLPPPPPPPPPRRRRRRRRKREVILIVLVVAVGGGGGGGGGGEEDDEDDEEEVVVVAVVIVVP---------AAAAAAAPAALLVLVLLVVVAAAAAAAAAAVVIIVIVVVVAAAGTAAVTAAGSVAAAPSPVVVIVVVVTVMMMM-MMM-VAVAQAAAAAAPPVVEVPPPPLLHLLLLLLLKKKKRKKKRRGGDDGDDGGGNNRNNNNNNNDDDDDDDDDDMLLLMLLMMMVIIIVIIIIIAAAAAAAAAAIVVVIVILILIILLYLLTYIIIIIIIIILILLLLLLLLLLEEKQEKEEEENNNNNNDCNCTSTTTTTTTTLLLILLL-I-

--------M---------I---------L---------E---------K---------A-TNDANDNDDDDDDDDDSDED--G-GGG--GMMMMMMMMMLPPPPPPPPPPGGGGGGGSSGVVQVTVVVVVNNNNNNNNNNGGGGGGGGGGCCCC-CCCCCLLLLLLLLLLPPPPRPRSSPLLLLLLLLLLPPPPPPPPPPVVVVTVSVIVTTTTQTRTTTAAAAAAAAAASSSSSSSSSSQRRQRRRRRRLLQLMQMLLQVVAVAAAAAADDEDEEEDDEKKKKKKKKKKIIIILVIIIIKKKKKKKKKKSSPSSTSSSSQNQQQHHAAHLLLLLLLLLLAAIAVVVAAVKKRKKKKKKKHNDNDDDNNDNNNNNSNNNNQQSQSASSSSIITITTTIVTSSASSSSSSSDDQDQQQDDTVVVVVVVVVVVVYVYYYTTYLLLLLLLMMLGGGGGGGGGGHHHHHHHSSHIIIIIIAIIISSICVIIVVVSASSSSSSSS

AAAAAAVAVAAAAMACVAVMDDDDDDDDDEDDDDDDDDDDPPPPPPPPPPIMMMVMIMILGGGGAGAGAGVVVVVVVVVVTTTTTTTTTTVLVIIIILIIGGGGGGGGGGSSSSNSSSSSGGG-GGGGGGFFFFFFFFFFYYYYYYYYYYAAAAAAAAAATTQTTTTTTTKRKRKRKRKRKKKKKKKKKK-----L---------V---------P---------K---------I---------S----SNSTSSSSSSTTTTTTTTTTRRRRRRRRRRFFFFFFFFFFAGGGGGGGGGIIIVIIIIIIIIIIIIIIIILLLLL-LLLLIIIIIVIIIILLLLHLLLLLHHHHQHQHQHQVQLQVNVQVSSSSSSSEASLLLILLILLLEAESEAEAEALLLLLLLLLLYYYYYYYYYYTKTTTTDHTTDEDQDEDENEIVVIVVVVVIFVFFFFFFFFWWWLWWRWRLAAAAAAAAAAVFV-V-VFV-DEEDDDDEDD

MMMLMMLMMMPPPPPPPPPPLFLLFLLLLLTSSSSTNSSAFEEEEEEEEENNNNNNNNNDIIIIIIIIIISSSSSSRSSSHKHSEHSSSKTTTTTTTLTAIKKNKKNTTKGGGSGGAEAGVIIIIIIVVLLLLILLLLLLLLLLLLLLLLLLLFLLFFFLKTKKMKKKKKFFFFFFFIIFCRCSRCTSSSYYYYYYYYYYRRRRRRRRRRVTIETIEEETSASAAAAAAADDDDDDDDDDAPAAPAAAAAYYYYYYYYYYWWWWWWWWWWKKKRKKRRRKAIAVIVVIIIKKKKKKQKKKRRRRRRRCCRMLLLLLLRRLKKRKKKKKKK

LLLLLLLLLLIIIVIIIMVIQQQQQMQQQQNQQQQQQQQQLLLLLLLLLLMMLILIILLLSSSSSSSSSSSSRSSSSSSRDDDNDNNDDDAAAAAAAAAADDDDDDDDDD-----S---------I---------G---------M---------P---------S---------W---------F---------G---------V---------F---------R---------G---------F---------G---------E---------L---------V---------W---------D---------S---------I---------K---------D---------Q---------F---------D---------P---------A---------D---------C---------E---------P---------D---------A---------P---------I---------K---------I---------L---------V---------T---------P---------E---------L---------G---------K---------E---------G---------P----HHEQHAHHHHLLLMLLMLLMTTMTPTTPTLDDDDDDDDDDCILLMLLLMLGGGGGGGGGGEEEEEEEEEEYYYYYYYYYYGGGGGGGGGGIIVIVIIIIIKKKKPKKPKKTTTTKTTKTTGGGGAGGAGGSSSSGSSSSSIILVIMIIILFFFYFYYFFFAAAAAPAAAASNNNTNNNNNEQQQQQQQQQIIIRVRRVKIPPPPPPKPPPEEERAEEAEE----A---------P---------L---------K---------T---------V---------G---------K---------V---------L---------I---------N---------Q---------K---------E---------Y---------D---------V---------L---------F---------S---------A---------Y---------L---------T---------V---------I---------A---------G-----

SAASSSSASSDDDDDDDTDDGGGGGGGRGGIILVIVVVVVQQQQHQQKQQESSESQQQQQPPPPPPPPPPEEEEEEEEEE-KH-H--H---YY-Y--Y---SS-S--S---EE-E--E---NN-N--N---CC-C--C---KK-K--K---TT-T--V---TT-T--T---HH-H--H---SS-S--S---EE-E--E---II-I--V---KK-K--K---VV-I--V---TA-T--T---RR-R--K---VV-V--T---AC-C--V---AD-A--D---VV-T--V---DD-D--D---SS-S--S---KK-K--R---LL-L--L--

FFFFFFFFFFIVIVIVIIIIV-V-V-V--VGLGVGM-GGGIILVLVIIILVTVTVVIVTVDDDDDDDDDDGEAEGEEEEGRNRKRKGKKRRRRR-RRRR-LLLL-LLLL-YYYY-YYYY-QAQA-AASA-SSSS-SSSS-NNNN-TNNN-NDND-DNND-LAIA-GEAA-QQQR-EQQQ-DNDD-DDDD-LLLL-LLLL-RTRT-TRRT-VTVV-VVVV-SNSN-NSSS-LMLM-MMLL-RS-H-SRRS-IIII-IIII--GGS-GGGG--VIV-VIIV--DDD-DDDD--VIV-VIII--KQK-KQQK--AAA-VAAA--PPP-PPPP-

KKKKNKKKKKGGGGGGGGGAVVVVLVVVVVVIVIVVLVVILLLLLLLLLLCCCCCMCCCCLLLLLLLLLLQKQKKQQKQKLLLLLLLLLLAAATAALAASVIVIIVVIVIAAAAVAAAAVDDDDDDDDDDKKKKKKKKRKHQHQQHHQHQKKKKKKKKKKLLLLIFFILLEEEEEEEEEEDEDEDDDDDEPPPPPPPPPPMQQQQMMQSQPPPPPPIPPPSMKMMTTMTMSSESSSSSESGGSGGGGGGGMMMTLMTLMMYYYYYYYYYYSSASSSSSSSACSCCAACSCDLQLLDDLQLDDDEEDDDDEKK-HKKKKKKGGGGGGGGGGWWWWWYWWWWGGGGGGGGGGVFFFFMMFFYRRRRRRRRRRAAAAAAAAAA

KRRRAKKKRKPSSPAPPPSPLLLLLLFFLFRRRRRRRRRRESDEEEEEEEQKKKKKQKKKIMMIIIMAMILILLLLLLLIIIVVIVVVVVQKKKKRKKKKEEEEEEEEEEVVVVVVVVVLWWWWWWWWWWSVAAAAAAAAVVVAVVGGVGRKKKKKKKKRVVVVVVVVVVDDDDDDDDDDTTTTTTTTTNLLLLLLLLLLNNNHNHHHNHEEEEEEAAEEEEEEEEEEEEQQAQQQKKAKGGGGGGGGGGSASSSSEESEKKKKKKSSKKVTVVRVIIVVSSESSSTTSDHHHHHHHLHHRRRRRRAAHSPPPPPPPPPPASAAAAAAEAKKKKKKKKKKPPPPPPPPPPKKKKKKTTKTAAAALAAAAAASPKKKKKAK

KKNKKKNKKNSSASSSSSSSWMWWWWWWWWKKKKKRKKKKFFFFFFFF-FNSTRRNTNTTRRRTTRRRRRFFFFFFFFFFGGGNNNGGGGGGGGGGGGGGKKKKKKKKRKILILLLIILIPPPPSPPPPPGGGGGGGGGGASMAAAAASSNDNNNDSNNNSDKDDDKDDEILFLLLFLLFRRRRRRRRRRLLLLILLLLLMMMMMMMMIMSSSSSSASSSNSQNNNQNSNTSVEEEATSAGG-GGG-GG-FFFFFFFFFFKKKKKKKKKKWWWWWWWWWWLLLIIILLLLHYYYYYYEYYLIILLLILIIQHQQQQQQHQLILFFFLLVL

QQQDQEQQQQRRRRRRRRRRGGGGGGGGGGLVITIIITIIFFFFFFFLFFTAAAAAMAAANNNNNRKSRNPPPQSSSSNSVVVMMMVKMMAAAGAGAGGGLLLLLLLVLLRRRRRRRQRRSASAATAAAASSSSNSSSSSSTSIMMMMMMVVVGVVVGVVNHHNNNNNNNNGNGGGGGGGRRRQRRKRKRAAAAAAAASAPPPPPPPPPPSSSDSSASSSILIVVVVVVVHHHHHHHHHHQQTIMMTIMMHHHHHHHHHHNTTSTTTTTTGGGAGGGAGGYYYVVVYVVVQQQQQHQQQQLPLPPPPPPPAAAYYYAYYYLLLSLLLLLLKKKANNNANNVVVVVVVIVVIIIIIILVIIYFYFFFFFFFEEEEEEEEEE

WWWWWWWWWWIIIIIIILIIRRRRRRRRRRLLLILLLLLLLLALMLILLIHHHNHHHHHHLLLLLLLLLLQQQQQQQQQQASSSSGSSSAVFFFFVVVFVILLLILIIIICGGGGLCLGCDDDDDDDDDDEDDDEEDEENF-FFFFFFFFDEEEEEEEQEPPPPPPPPPPHHHHHHHHHHATPQAAAAAATTTTTPT-TTGHGGGGGGGGPPPPPPPPPPWWWWWWWWWWTTTTTTTTTTKRKKKKKKRKFFFFFFFFFFQQRSQHQHQQVAAAAVVVAVGGGGGGGGGGWCCCWWWWWWPPPPPPPPPLMMMMMMMVMMPASSSSSSSSCCCCCCVVCVFYYYFYFYYFLLLLLLLLLLCAAAACCCACDDDDDKDDDD

LLLLLLLLLLTTTTTTTTTTNNNNNNNNNNIIIIIIIIIIVFLVVLLFVVSGSGSSSGSSEEEKEEEKQEQRQEEQQEKKIIIIILIIII-------I--IIIIVIIIVVEEEEEEEEEEFFFFFFFFFFIIIIIIIIVVFFFFFFFFFFPTETTEETTTVVVVVVVVIIPPPPPPPPPPKKRKKKKKKKQQYQQYYEQQCCSCCSSSCCMMMMMMMMMMNNKNNNNNNNEDEDEEEDEEVVVVVVVTMVYFYFYHYFYYPPPPPPPPPPYYYYYTFYYYPPPPPPPPPPNTSTVSSTTSGGGGGGGGGGDDDDDDDDADNNNNTNNNNNKKRKKKKKRRLLLFLLLLLLLLLLLLLLLLRRRRRRRRRREATSATTSAAFEGEFTSELF

EQEQQQEQQQVIVIIIIMIIYYYYYYYYYYRRRRRRRRRRVVVVVVVVVVLLFLLLLLLLHQNNNQNNNNHHHHNHHNNNAQAHAQALQQGGGGGGGGGGTVTTTTTTTTYYYYFYYYYFTTTTTTTTTTENEEEDEEEEVTVIVVVVVVQQSQQQQEQQVVVVVVVVVVVVVVVVVVVVVLVVIIVVIIKKKKKKSQHKQQQQQQQQQQEEEEEEKEEENNNNNNNNNNFFFFYFFYYYIVIIIVLIIIGEGGGGGGGGNNQNNNNNNNMMMMMMMIVIPPPPPPPPPPGGGGGGGGGGSTSTTTPTTTGGGGGGGGGGAAAARAAAARGGGGGGGGGGPPPPPPPEPPLLMLLLLLLLLLVLLLLFLLRRARRRRRRK

AAAAAAAAAAKAQKKQAKKKKKNN-DKRKRRRKKRKRGRG--GG-G----TTTTNSTTTTQQDEQDRQQQWWWWWWWWWWRRGHRGKRRRGEEEGEEEGEPPPPPPPNPPSSSSSSTNTSTTTTTTTTTTRRKRRKTRRQRRRRRRRRRRYYHHYHYYYYASSSASSSAAGGGDGGGGGGQQSQQQQLQLSSNNSNSSGSVI-IV-IIVILL-IL-LALAQQ-HM-QQQQSS-SS-SSSSDN-DD-DDDDVV-VV-VVVVGE-EG-EGGGEE-EE-EEEEIL-LL-LLILRC-CR-CRRRVV-TV-VVVVVVVVVVVVVVNNSSNSNNND

PPPPPPPPPPTTTTSTTTTTRRRRRRRRRRGGGGNGNGGAAAIVAAAAAAPS-PSPSPSPFFFFFFFFFYRGRRNRNRNRAAAAAAAAAGQKQRSKTKKELFILFFFFFLIIIIIIIIIIRRKRQRQRQRYSYYYYYYYFVVVVIVIVVVPEPPEAEPEPNDEEDDDDDNVVVIVVIVVVLLLLLLLLLLAVAMASAAAALLLLLLLLLLPPPPPPPPQPTAAAAVAAAAEDDDDDDDDEKKKKKEKKKKGTGGAAAAAGGHGGGGGGGGVLVVLVLVNVYFYYFYFYFYPPPPPPSPPPRR-RQRQRRRAA-AAAAAAA

IIILVIIVILNNSNNNNNNNWWWWWWWWWWDDDEDDDDNDGGGGGGGGGGTTTTIITIITRRRRRRRRRRLLLLLTILLLMMTTMMTMMTEENDHIDHDDDEDDDDDDNDAAAAAAAAAAHHHHYYHYHHTTTTEATETTIVIMGGMGVLAALSAACAACAAAAAGAAAAPPPPPPAPPPSSCYCCCCCCFFWYFFYFFYFFFFFYFFFFQQQQSQQSQQHHHHHHHQHHDDNFEEDEDDPPPPPPTPPPLMVVVVVVVVAAMIMMMMMMTTAAAAAAAARRRQRRERRQVKRRRRRRRRMMMKILMIMMVVVTVVIVVTVVVLVVVVVLEEEQEEEEEQRRRRRRRRRRDDDDDDDDDDPKPPPPPPPPRRRRRRRRRR

KQQQQQQQQKWWFWWWWWWWLLLLLLLLLLNKNNNNNNNNTSVVTVTSVTLTLLILIILLI-IIIIIIIIQQQQQENQSQVLVVLVLLVVYYTTYYYYYYDREEKEKRADDDSSDEDDPDLLLLLLMLLLREQKEQDEQRIIVVIVVIVIGGGGGGGGGATTTTTTTTTTANSSNSSKSNQQQQQQQQTQNNNNDNNNNNAPPPPPPPPAFFFFFFFFFFDHDDHDDHEDKKLMKKKKKKVIVVVVVIVVLLLLLLLLLLFFFFFFFFFFLLWWLLLLIL-RRRRLRRR-ASEESEASEAI-VIVVI-VIA-AAAAA-AAAVEEVAVVAAMMLLRLMMLMRNQQNQNNQKAAAAHAAAAALIIILLLLLLMMLLMLMMLMKKEEKKKKKKAEASESATSASSSSSSSCSS

LLLLLLLLLLEEEEEQDEEETNTTTTTTTTVVVVLVVVVVKQKAKKKAKKIMMTMMMVMTHHHNYHHNHHYYYFFYYFYFDDDDDDDDDDVIAAAV-AVAKRKKKK-KKKEEEEEK-ESEYYQEEY-EYEGGHGGG-GGGKKKKKK-KK-SKSCSK-CKSIIIIII-IIIEEEDDD-DDDFLLLLL-LLLVLLLLL-LLLPPPPPP-PPPFFIIIF-IFIQQQQQQQ-QQGGGGGGG-GGGGGGGGGGGGEEEEEEEEEERRRRRRRGRRAAAAAAAATAVCVVVVVVVVDDDAADDADAYTYYYYYYYYPPPPPPPPPPSSTSSSTSSNVLMAVFMVFVIIMIIVIIVIRRRRRRRRRREEEEE-E--EDDDDD-DD-DVVVIVVVVVVGGGGGGGGGGFFFFFYFFFI

GGGGGGGGGGAAAAAAAAAAMLMMLLLMLMEEEQEEEEEEGGGDAGGDAD-Y---YY----T---TT----V---KV----K---KR----S---SS----Q---EQ---QEQEEAEEEEQQQQQQQQQQGGGGGGGAGARKRRKKKRRRLLLLLLLILLCASCCAACCCLLLLLLLLLLGGGGGGGGGGIIIIIIIILIAVAKAAVKAKSTSTTTTTTTHVIFIVIFIFVVVVVVVVVVASSAASSMAAFFFFFFFFFFGGGGGGGGGGSSGSSSSSSS------A---NNKKKNNRKRNNNNNNNNNNEEEKEEEQKQIVIIIIIIIILLLLLLLLLLKKKKKKKLKKASAANSKANAEEEEEEEEEE--L---------E---------W---------R---------A-------ARCSCCRSCTWWWWWWWWWWVVVVVVVVVVRRRRRRR-R-PPPPPPP-P-MMMMMMM-M-

QNQNNNNSNNEEEEEQEEEESGSGGGGGGGIIII-IIIIIRRQR-RRKRRAAAA-AAAACQQQQ--QQQQIIVI--LLLLQQEQM-EQEQVVVVVVVVVVDDDDDDDDDDSSSSSSSSLSIVIIVVVVVVAAAAAAAVAARKRRKKRKRGEEEEEEEDEDCCCCCCCCCCYNYNTNNNNNRRRRRRRRRRIFFFFFFFFFVVVIVVIVIVTVTVVVTVTVTTTTTTTTTTLFIFFFFFFFPAPSASPSPSEAEAAEAAAATTTTTTTTTTFVFLIFFVFISSSSSSSKSSLMLMMKMFMFDDDDDDDDDDRIRIIKKKKKGGGGGGGGGGVAVVAVLVVSGSGSSSGSGSLLLLLLMLML

ILIIIIIIILAVVVVVVVVADDDDDDDDDDLLILIILIILGGGGGAGAAKRRERESRSSRTNDSDDTDDTLLLILLLLLLAAAATAAAAA-------N---------A---------L---------L---------V---------F---------A--LLLLILLLLLILMMMMMMMMRRKKKKRKKRAAAAAAASAA-----N-N-------N-N--YFFHFYHFFYMMLMLLMLLMASAAAAAAAAASSSSSSSSARRERENRNNRNNKNKKNQKNRRKRKKRKK-VAGSGASAAAPPPPPPPPPPKKKKKRKRKKLLLLLLLLLLRLLLLLLLLRVVIVIIVIVVYYWYFWYWWYIITITVIVVIIIIIIII-IILLVLPIL-VFEKEKEEK-EERRRRRRR-RRGGGGGGG-GGHHNHNHH-HHTTTTTTT-TTFWLFFFFFFF

STETSTTTSSPPPPPPPPPPLVLLMIIVLLGVGGGGGVGGIIIIIIIIIIQQQQQKKQQQVI-IILLIIVEE-EEEQEEEEE-EESSEEDII-ITITITICCCCCCCCCCEDEEEDDEDEIMIIIIVMIITTTTTTTTTHKKKKKKKKKKSDDEDDDDESEPEEEQQPRELLLLLLLLLLGGGGGGGGGGKKKKKKKKKK-T---------K---------D---------D---------H---------L--------DDDGDDDEDD--S-------VVATTVIVIVFLFFFFFFFFVLLLLLLLLIAGGGAGGGAAVAAAFAEAAVERSRRRRRKQGAAALPPALAEDEEEDDDEEYYYYYYYYYYDDDDDDDDDDLLLLLLLLLL----I---I-Q-QQQQQ-QQI-VVVVV-IVM-AAVMM-LMLLLLLLVLLL

AGGNGGDNNGVIIV-VVYVIVLLVVLIIVLEAAEEAAVEATTNTTTTTTNQRRQQRRRHRSSSSRSSSSSEEEEEEEEEE-LL--LLLLLVFFVVIVVVFKRKKKKKKKKEKKEEKEEEKDEEEDEEEEEDDDDDDDDDDV--VV-TTV-SSATTSSSSAVVVVTVVVVVLIVLLVVVLVPPPPPPPGPNKHLKKHHRKHYFFYYFYYYFRRRRRRRRRRMMMMMMMMMMDDDDDDDNDDKRRKKRKKKRLILLLLLLLIANNAANNAANWWWWYWWWWWCNLCCNTAALGKKKKKKKKKTATTTTTTTTRRRRRRHRRRAAAAASAKAAKKKKKKKKKKGMQMMMMTMQRRKRRRRRRKYAEYYAAYYARYYKKYKKKYFLLFFLLFFLVIILLIIILVMYFMWFMMMFIFFIIFFTLFGGGGGGGGGNGGGGGGGGGG

RGGGGRGRRGARARVARAARSPSASKASSATSSTTSSSDSDDNQNDEDDDFFFFFFFFFFGGGGGGGGGGLLLLLLLLLLNHNNNNHNNNLRRRRRRRRRWWWWWWWWWWSTITISTAATVIVIVVIVVIKPSPSKPKKPKKKKKKKKKKYYIYYYYYYYGGGGGGGGDGVVVVVIVVVVLLLLLLLLLPGGGGGGGGGGFFFFFFLFFFKHHHHKHRRHLLLLLLLLLLHYYYYHYHFYCCCCCCC--CNGGGGNGNNGILLLLILMMLQEQEQQEQQEEQQQEEQEEQNNSNSNNNSNFFFFFFYFFFLILLLLVLRLMIIIIMIVMLNDDLDNDNNDKRKRKKRTNRTTTT-TTTTTRTTTTRTTTT

VVVTVSITVVQQQQQQEQEQCSCGAGCCCCDDDDDDDDDDAAVSAATATATTTDTDEDSTVVLVIVLVLL-GGAGSSAGG-HHHQHHHHH-GRGRGRGRRDDVDDDVDVVYYYYFYYYYYQQQQQQQKQQEEEEEEAEHEKKNKKKR-RHVVKVKVKIKKSNNNNNNNNNYYYYYYYYYYEQEEE-EEEEVVVVVVVVVVKKKKKKKKKKGGGAGAGGGGVVLLIFVVVPLLLLLLLLLLKKYERKKNKKDDDNDNNNNNEEDEPEDEDDAAAAAAAAAAGGGGGGGGGGAAAAAAAAAA---S-S-S--YYYLYFSFYYRRWRRRRRRRCCCCCCCFCCGGGRGRARAGGGGGGGGGGGLKLGIGLGLLGGGGGGGGGGGNNNNNKNKNFFLFFFFFFFLLLLLLLLLLTTTLTLTTTTPPSPPPSPSSAAAAAAAAAA

-EEETEEEED-HHHHHHHHH-YYFYYFYYF--LLLLL--M--LLFLL--L--IIIII--I--SDNND--D--LLLLL--L-IIIIIIVIISSTTTTTSSTTPPPPPPPWPEEEEEEEEEERRRRRRRRRREE-----EE-VV-----VV-NN-----NN-LLLLLLLLLLFLLLILLLLITTTTTTTTTTTTTTTTTTTTNNNNNNSNNSGGGGGGGGGGAAAAAAAAAAEEEEEEEEEEEESTSSTEETIVVVVVVIVVTVTTTTTTVTLLPLLLLLLLWFFFFFFWFFLVVVVVVVVVALAAAAAALAEEEEEEQEEQGGGGGGGGGGEEEDQEEEEEDDDDDDEDDEG-GAGGAG-A

-VLLA---L-TTTTTTTTTTPPPPPPEPPPTMMMQTATTT-TTTTI-LTLNSSSENNDEDLMMMAMMMLMKRRIRKKKRKQQQQQRQRQR-----D-----------D--PPPPPPPPSPLIIIIILIIVTTTTTSTTTTIIIIIIIIIIDDDDDDDDDDKRRRRKKNREYYYYYYYYYHDSDDNGDGNGSEAASSSSSSPAAAAASPASKKKKKKKNKKQTTTAEESTSMMMSMMMMIMGLLLTGGGAGEEEEEEEEEETTTTVTTPTSNNNNNNNNNNYYYYYYYYYYRSRRRRRKRRHHHHHHHHHHFFFFFFFFFFAAAAAAATPTSSSSASSSASWWWWWWWWWW

IVIVVIIIIINEEEEENEEEAHAAAAAAAASSSSSSSNSSFFFFFFFFFFRRRRRRRRRRDDDNDDDDDDG-GGPGGGGG------E---S-SSSSSSSSL-LSLLLLLLYYYYYRYYYLVVVTVTIVVTAGACSAAAGAFYFFYFFFYFEE-EEEEEEEPP-PPPPPPPGG-GGGGGGGSN-SNSNSTAEE-EEEEEEEKK-KKKKKKKIVIAVAIIVAYFFYLYFFFYLLLLLLLLLITTESTRTTTSSSSSSSSSSAEEEEEEEEEETTTYTTTETSGGGGGEGSGGVVEVVVVETVVAVVVIVVVV---K------FYYYYYYYYYTAAAASAAQSSSSSSSSSSSHHHQHQHHHQRKRKKKRRKKDAGGAGDGADRRRRRRRRKRTTVVTVTVTV

LLILIILILLVVVVMLVVVVAAAAAADAAAIAAAASATAATTTTTTTTTTRRRRRRRKRRGGGGGGGGGGSSSSSSSSASGGGGGSGGGPERRRRRRRRKFFFFFFFFFFTMTTTTQTTQYFYFHHFYYFGDGGGGDGGDFFFFVFFFFYPPPPPPPAPPAAAAAAAAAAIFILIIFILFLLLLLLLLLLRRRQRRKRRKSGSDAAGSSGCRCCCCKCCRTETETTETEEKMKRKKKKKKWWWWWWWWWWKGRGRWGGGGQKQKQQRQQKKRRRRRRRRRVVVVVVVVVLAAAAPPAASGSSNASSTSSTSVSSSSQSSQNANANNAAAAQQQQQQTQQQLILILLIVIIYFYYYYFYYFHEHEHHEEEEHHHHHHHHHHRKRRRRKRRKMLMLMMLMLLIVVVVVVVIVEEEEEEEEEA

NNNNNNNNNNNNNNNNNNNNTSSTTSSTTSDDDEEEEEEEGGGSGGGGGGYYYYYYYYYYLLLLLLVLLVMMMVMMMMMMLLLMMLLLLLQQQQQQQQQQQQQQQQQQQHEEEEESEEEEEEEEEEEEEENNNLNRNNNNHYYHHHRYHHFLLFFFFFYFSKKSKKKSSKFLFFFFFFFFCCCCVVTCCTHHHHHNYHHHYNSCCCCCSCQRRRVVVRQVTSHSSSSSTSTTTTSLSTTSLLLLLLLLLLRLLLLLLQRLAAAAAAAAAALLLLVLVLLVVIIIIIIIIIFYYFYYYFFYKKKRRRRKKRLLLLRRRLLRFFFFFFFFFFSSSSSSASSSSLLSLLLSSLTTTTTTVTTVVVVIVIVIVITDDTTTTTTTSTTTTTTTTLPPPLPPPLPPTTTTTTTTTTLLLLLLLLLL

KKKKKKKKKKKPKKKKKKKPTCTSSTSTTSLLLLLIYLLLRRRRRRRRRRVVVVAVVVIVNDNNKNNNNSMIMIIIVMMIAAAASSAAAAIVIIMIIIIVA-AAAAAAA-EKAKEEEAEKSSSSSSSGSSEEEEEEEEEEVEVAEEVIVEPSPSSSPPSSEEEQDDEEEEDKEKKKEEDKWWWWWWWWWWEEDEEEEEEESGEGGGSDGGRRDRRRDDRRDNDDDDDDDEIIIIIILIIIEEKEEEEKEENSNQNNNNNSRPRPQQRRRPKKKKKRKKNKTTTTIRTTTTRRRRRRRRRRLLLLLLLLLLLLLLLLLLLLTTSTTTTTTTPPPPPPPPPPNQKQQQKKNQVASAAHSSSANFNFFFNNNFQQQQQQQQQQQDQEEEQQHDKRRRRRKRRRTTTTTTTAVTTNANNNTANN

GGGGGGGGGGYYYYYYYYYYLFLLLLLLLLSSSSSSSS-SLLLLLLLL-LRRRKRRKK-RYYYYYYYYYYKKKQKKQKKKIIVIIIVIIIPKKRPKRKKKKKKKKEKEKKKKRRRRKRRKVVVVAVVVVVAAAAAAAAAASTTTTSTTTTEEEEEEED-PVLIIVIIIIVSSSESSSHSSEDEQEGGGEEAAPAAAAAGAEEEEEPYPEDHHQQHQQQQQPAAAPAAAAAVVVIVIIICVVVVLVVLVVVAAAAAAAAAAFTFFFFFFF-LLLLLLLLLLKKKKKKKKKKVVVVVVVVVVPPPPPPPPPQIPPPPPPPPP

IIIMIIIIIIRRRRRRRRRRIIIIIIVIIIRRRRRRRRRRPKKKTKKTKPDGGGGGGGGDIFFFIFFIFIVVVVVVVVVVVLLLLLLLLVEEEAEEAEEEIIIITVIIIIKRRRQRRKRKAVTAAKAAKAGGGGSGGGGGVVVVVVVVV-GGGGGGGGG-LMMVLMVLM-TTTTDTTTT-FFFYFFYFF-FFFFFFFFFFQQQQRQQRQQSSASSASSASSSCASCAACNDDDDDDDDDDPPP-LPPLPPCCTCCTCCTCEEEEGEEDEDEEEEEEEEEENNNNSQDSHNRRRRRRRRRRILLLLLLLLMIVIVVVVVVINSSSNSSNSN

DDEDDEDDDDHHHHHHNHHHQQQQSQSQHQIAAVIIIIAIIVVIVVVIVV---D------GGGDGGGGGGFYYFGYGFYGIVVIIIVIVIRRRRRRRRRRLLLILLLLLLRNNRRRRRNRFFFFFFFFFFLLLLLLLLLLLLLLLLLLLLVIIVVVVVIVRAAAAAARAADDDDDDDDDDRRRRRRRRREIVVVVVVLVVETTEEEEETEARRAAAAARAEEEEEEEEEEYLYYYCYHYYVKSVIVVVSVDDDDDDDDDDLLLLLLLLLL-KE-----K-TMMTTMTTMTRNQRRQRRQRKKKKKKKKEKREKRRPRRER------V---------V---------A---------I---------Q---------Q---------Y---------I---------E---------Y---------V---------A---------Q---------A---------T---------K---------E---------I---------I---QHHQAQQQHQGGGGGGGGGSTTTTSTSTTERRRRKRKRRKLLLLLLLLLL

VIIIIVFVFVGGANGGGGGGPPPPPPPPPP----E---------V-----EEEEEQEEEEGGGGGGGGGGNDDDDDDNDDLLLLLLLLLLKTTTTTNKNTGSSSSSSGAGAAAAAAAAAATTTTTATTTTIIIIILIVILRRR-Q--R--EEE-E--E--LLL-L--L--FFF-F--F--AAS-A--A--RKQ-Q--R--AAA-A--A--QEE-E--Q--LLL-L--L--ASA-A--A--DDD-D--D--QQQ-Q--Q--SDD-D--D--SSS-S--S--LLL-L--S--TTT-T--T--VVV-V--V--TTT-T--T--GGG-G--G--GGG-G--G-----R-RR-RR---G-GG-GG---A-SA-AS

GGGTATGGGGFFF---FFFFQQQ---QQQQAVV---VVVSYYY---YYYYLLL---LLLLGGG---GGGGAAA---AAAA------L---------K---------H---------R---------D---------D---------V---------F---------D---------L---------E---------D---------D---------V---------E---------F---------S---------Q---------R---------N---------F---DDD---DDDNSYS---YSYYTIT---VTVIVVV---VVVVLVV---VVVVIII---IIIIEQE---EKEETTT---TTTTTTT---TTRVKKK---QKKKLLL---LLLLHHH---HHHHLLL---LLLLTITTTTTTTTAAAAAAAAAALLLLLLLLLLGGGGGGGGGGEDDEEEDDKDVILVVVILIIGGGGGGGGGGKKKKKKKKKKIYLLLLLLLLLVLLLLVLVVKKKKKKKKKKDDDDDDDDDDSSTSSSSTSSFFFFFWFFFF

WWWWWWWWWWFFFFFFFFFFLVLVVVVVILGGGGGGGGGGTTT--T--TTDDDDDDDDDDFFFFFFFFFFEQEEEEEEEELIIIIIIIILRRRLRRRRRSSSSNNDNNDSAEAAAAAAAAGGGGGGGGGGDDDEEQEEQDYYYYYYYYYYS--------SL--------LD--------DR--------RA--------VA--------AG--------GT--------TP--------PK--------SL--------FL--------LW--------WY--------YD--------DG--------GW--------WY--------FT--------TS--------SI--------LE--------EA--------CA--------AS--------SL--------LR--------RK--------KE--------EY--------YP--------PE--------EI--------IT--------TK--------KP--------TAHHKKHKKHAVVVVVVVVVVDDDDDDDDDDRWW--WWWWRKKTKKKKKKKNEGEEDEEENMMMFFMIMMMLLLLILLLLLEEEDDEREEEGGGAAGGAGGTAAAAAAAATQEQQQQQQQQPPPPPPPPPPSSSS-ASSSSEDED-DDDDEKKKK-KKKGKGGGG-GGGGGSAAD-AAAAADYDD-DDDDDNDND-DDDDNLLLL-LLLLL

NNNNENENNNAAAAAAAAAATTTTTTTTKTLLLLLILLLMRRRRRRRRRRIIVIIIIVIVNNNNLNNNNNIIIIIIIIIIFFIIFFFLIIFFFFFFFFFFHHFHFNFFFFSSSSSSSSSSEKKKKEKKKKVVAVDVDAKAFFYYNFYYYYKKKEEKEESERRRRRRRRRRDDDDDDDDDDASRSRSRRRRLLLLLLLLLLKKKRKKKKKERRRRKRRRRRHH-Y-H----GG-G-G----DD-D-D----ND-M-N----MY-Y-M----VV-V-V----TT-S-T----LL-I-L----NN-N-N----TT-T-T----AA-A-A----GG-S-G----EE-E-E----

GGGGGGGGGGSSSSSASSSSMAAVIAMAMANNNNNNNNNDREEDDDDDDEEEEEIQEEEQAAAKKAAKAAAAAAAAPAAAAAAAAAASAAFFFFFYFFFFDDDDDDDDDDKKKKKKKKKKRSRRRRRRRRQQQDDQQDQQGGDGGGGGGGEEEEEESEEEIIIIIIIIIMKSSAASKAKSQQQQQQQQQKTTTTTTTTTTTTISTTTTTTLLLFLLLLLFKGGNNGGNKGTTTTSTTTATFFFFFFFFFFPPPPPPAPPPAAASSAASAAKKKQQKKKKKYYYYYYYYYYPPP--PDPPPPPPPPPPPPPFFFFFFFFFFSTTTTTTTSTGGGGGGGGDGVVVVVVVVVVDDENNDDNDDGGGGAGGGGAYYYYYYYYYYYYYYYFYYYYNNNNNNNNNNKRRKKKKKKRNNNNNGNNNN

VVVVVIVVVVILIIIIIIIIEEEEEEEEEEDNNNNNNNNNLVVVVVVVVVKKKKKKKKKKYHYYYYYSYHLLLLLLLLLLTTTTTTIVTVIMMMMIMMMLLLLLLLLFLF------S---R-K-RR-RDRS-V-IS-TITN-N-NN-NNGL-L-LL-ALLG-G-GG-GAGL-L-LL-ILIA-A-AA-AASN-N-NN-N-N-----H----EEEEEEED-D-L-L-------S-S------AAAAAAAA-AWWWWWWWW-WAASAATAA-AGGGGGGGG-GLLLLLLLL-LIVIIVIIQ-AQQEQQQQQ-QIITITTII-IKSKKKKTK-KNNNNNSNN-NLLLFLLLL-LNNNNHDND-K-Y-Y--F----L-L--L----P-P--P----C-C--C----G-G--G---IIVIVIII-ILLLLLLLLLLTKKKKKKQKQSSSSSSSSSSSGGGGSGGGGPPPPPPPPPPLLLLLLLLMLKEEEEEEDEESSSSSSSGSSLLLVLLLLLL

HRHHHHQQRHAEQQESEEEQHMMMMHMMMMPPPPPPPPPPIIIIVIIIIIIFFFFFYTFFAAAAAAAAAALVVVVLVVVVPPPPPPPPPPQEEEEQEEKEAAAPAAAAAAFFFYFFFFIFQQQQQQQQQQVIIIVIIIIIAAAVAAAAAAEGSSSEEESS----L---------E---------F-----DEDDDDDDDDGGGGGGGGGSPPPPPPPPPPAAAAAAAAAANSSSSNSSSSHHHHHHHHHHNHRRHNAAHRVVIVVAVVVIVVVVVLVVVVEEEEEEEEEELLFLLLLLLLVVMMVVVVVMHHQQQHHHHQPPPPPPPPPP-AAAA-AAAATTTTTTTTTTQHHHHHHHHHDDDDDDDDDDTTTTQTTTTPPPPPPPPPPPIIIIIIIIIIYWKKMYYYMKSSASSSSNSASTFIVKTTTF

PPPPPPPPPPSSTSSSSTSSIQKNNQQQ-NKDKKKKKK-KI---------D---------H---------Q---------P---------A---------N---------L---------G---------S---------L---------L---------Y---------R---------P---------Q---------R---------H---------V-LTV--L-VVVVVVVVV-VDDDNNDDDDDEEDEEEEDEESSSSSSSSDDTIITTIIIIIGGGGGGGQGGIILIIIIIII--N---------A---------F---------D---------T---------S-------FLFFFFFFFFGGGRGGGGGGNNPNNNGNNNLLLLLLLLLLLLLHLMLLLLLLLLLLMFLLAAAAAMAAAATTTTKTTTTMEEEEEDDEEERRQKKRRARR-S---S-----L---L-----D---D-----K---K-----I---I-----I---I-----P---V-----E---E-----Y---Y-----P---K-----Y---Y-----R---R-----H---E-----A---A-----V---T----DDDDDDDDSSPPPPPPPPPPLIVLLILVLLAVMAACVMVL--F---------S---------D---------V---------V-------WWWWWWWWWWEKEEENEEEEE-SEEEESEELLLLLLLLILTSTTTTTVTTDDDDDDDDDDVVVVVVVVVLEDEEEEDEEELLFLLLLLLLE-NEN-EGEER-RRR-RRRRRRLRRRRLRREEEDEEEEEEQQQQQQQQQQGGGGGGGGGG----R-----HHHHHHHHHH

LRLLRLLLLLYYYYYYEYYYIVVVVVVIVVAAEAAEAAAAGGGGGGGGGGNNNNNNNNNNLLLLLLLLLLNENEENNNNNILLLLLLLLLRRRRRRRRRRDSDQSDSDDTTGNGGNNTNNPDPPDPPPPPKSQQQQQKKQGAGAAGAGGAMMMMMMYMMMHHHD-HHHHHSATAATTSSTEEEEEEVEKETTTTTTTTTTEKEEKEEEEESHSHHSSSSSVLILLILVVLRRRRRRRRRRDDDDEDDDDDIVVVVVVIIVGGGGGGGGGGVVVVVVVVLVRKRKKRKRRKNENEEHENNEWWWWWWWWWWLLIILIIIIITQGNNNETTEASSSSSSASS

-----A---------C---------G---------I---------D---------E---------F---------D---------E---------R---------G---------A---------M---------N---------M----LLIILIIIIIFFFFFFFFFFKKKKKKKKKKLL-LL-L--LII-II-I--ILLLLLLLLLLQSQQQQQQQQYYFFYFFFFFLLVVLVMVVLKKKKKLKKKKNNENNNNNKNEQQQQQQQQQQEQQQQYQQYGGGGGGGGGGQQMQQMEMMEEEQEEQEQQEPPLPPPPPPPPDNNHFHNNHRRRRRRRRRRIIIIIIVIIVYYYYYYYYYYEEEEEEEEEENNKKNKNEKNKKRRRRHRRRGGDGGDGDGGAAATAAAAAALLALLLLVLLRR-RRKR-KRRRRRRRRRRRNNDNNDNDDNGGAGGGGGGG---------RK---------R---------Q---------P---------R---------E---------EEEEEEEEKEGGTSGTGTSNTTTTTTTATTKKKKKKKKKKLLLLLLLLLLQQQQQQQQQQLLGGGGGGGGIVTAAAVTSVLLVIVIIIIIEEEEEEEEEEPPASPAPAAP------V--V------I--I------A--A------G--G------N--N

NNHHNHGHNDAAAAAAAAAAQKKKKKKKKKNNNNNNNNNNRRVVKVVVVKEEEEEEEEEEPPPPPPPPPPSSWWSWWWWSQQQQQQQQQQNNNNNNKKKNIIIIIIIIII--------R---------Y-NNSSNSSSSNTTTTTTTTTTVVVVVVHHHVTMTTTTTTMTEEEEEEEEEEEEQRQQQQQQEQEEEEEEEQSSSGSGSTSSGGGGGGGGGGKK--K-RDDKEGEEEEEEEEAAAAAAAVAAEEEEEQEEEEMMIIMIIIIMVI--------AA--------VV--------LM--------LL--------LM--------FR--------RR--------TTTTTTTSTT------VVV-------AAA-QQQAQKQQQQIIIIIIIIIIPPAAPAPPPPGGGGGGGGGG-------II-RRRRRRRRRRHHHNHHHHEHEEEEEEEEEEGGGGGGGGGGEEEEEEEEEEFFFFFFLLLF------P---------Y---TTTTETTTTT

KKKKKSKKKKTTTTTTTTTTVVVVVVVVVVAGARGAAAARTTTTTTTTTTTTTKTTTTTKLILLILLLLLFLLLLLLLLLHHWHAHHHWHA-NSSSAASSNTKNTTNNTNRRRNRRRRRTSGGGGGGSGGDDDEDDDDDEYYFRYFYYFRLLLLLLLLLLGILLLLGGLLFFLFFLFFLFWWWWWWWWWWLMMMMMMIMLSS-ST-SS-SWW-WW-WW-WVI-IV-VV-ITP-PP-PV-PST-NT-SS-NGG-GG-GG-GKS-KS-KK-KLV-VV-VL-LRRRTRRRCRKATAAAAAAAAPPPPPPPPPPKKKKKKKKKKILVVLLLIVVLLLLLLLLLL--L-------VVVVVVVVVVPEEPEEPPEPNK-KKKKK-QWW-WWWWW-WCCACCCCCACAKKKKRKKKKLLVLLVLLVLVAAASTASAAEEEESEEEEEEREEEEEEEEIILLILIILL

VAVAVVVVVVEEEEEEEQEEEEEEEEEDEELMLMLLMLLMSLSLSSSSSSYYYYYYYYYYLLLLLFFVVLTLTLTILSTLMKMKMMMMMKAAAAVAAVVAENENEQQEENNDNDNHNNNDAAAQYAAYYASKSKENQSSQVVVVIVIVVILGLGLQQLLHEQEQEEEEEELLLLLLLLLLMTMTLMTMMTKNKNKKK--NLYLYLFY--YRRRRRRR--RIIIIIII--ILLLLLLL--LYYYYFYY--YRRHRRRKRRRRRRRRRRRRRNNNKNNNNNNDDDDDDDDDD--N-N--NN-RRRRRRRRRRLLLFLLLLLMTVTTTTTTTSEEETEEMEEEIVVLVIIVVI

SCRSRSQKRSIVIIIVIIIIQKPKPKPPPKVAVVVVVVVVAAAAAAAAAAEEKEKEKKKEEEEEEEEEEE-------A---------P---------K---------E---------S---------G--FFFFFFFFFFGDSDSDGGSDKKKKDKKRKKIIVIVIIIVIFFFFFFFFFFS-SSS-SSSSV-SVS--MSVA--A--A--AN--N--N--SE-EEE-EEEDS-GSG-GGGSQ-SQS-QSSQM-LIL-ILLIK-QHQ-QQQQD-DDD-DEDDG-GGG-GGGGT-TT--TTTTQ-EQ--EEEQE-QE--EEQEA-YA--AFFAFFVF-FFVVFVIGVAVVAAVEEQEQEEQQEHHHHHHHHHHIVIIIIIIIITLTTTTTTTTDNDNDDNNDNGGGGGGGGGGEQEE-TEEEEVVVVVVVVVAAVSSSASTSSDNDDDDDDDDIIVVVIVVVIAAAAAAAAAAGDGNGDGGGGRRRRRRRRKRVVVVVVVVVI

QQQQQQQQQQVVVVVVVVVVPPPPPPPPPPTTTTTTTTTTEKKKKKKKKKAAAAAAAAAANNNNNNHDDNGLLLGQGLLQTTTTTTTTTTSNNNSASNNSAAAAAAAGAALLLLLLLLLLVMMMVVVMMVAAAAAAAAAAYYYYFYYYYYQQQQQQQQQQKRRSKRKRRDAAEAAAAAAAPPPPPPPPPPPILILVPIIIDAADDTDAADWWWWWWWWWWKKKKKKKKKKFFFFLFFFFF-KKQ---KK--IMI---FF--DND---DD--TTT---TT--SSG---SS--FFF---FF--EEE---DE--KKK---KK-NNNNNNNNNNQQQQQQQQQQWYYFWWWYYWANNNSSANNSQKKQQQRKKQNSSENRNSSREQDEEEEDDELIIILILIIIPPPPPPPPPPWFYYYYYYYYPPPPPPPPPPYYYYYYYYYYAAAAGGAAAG

TTTTTTTTTTIVVVVIIIVVVYYYYVYLYYLLLLLLLLLLPPPPPPPPPPLLLLLLLLMLAATTTATATTVVVVVVVVVVLLLLLLLLLLNSAAANAAAARQQQQRNRQNGGGGGGGGGGPGAGAPGPEGGSSSSGAGSSEEEEEEEEEEASSASASSSSILLLLILLLLFFFFFFFFYFAAAAAAAATAPAAASGAAAAEEEEEEEEEERRRRRRRRRRPPPPPPPPPPVIIIIVLIIFYYNHNYHYKHFFMIMFRFMKDEDDDDDDDDQRQQQRKQQQWWYWYWWWYWYYYYYYYYYYLLLLLLMLLMEQEEEEEEEESSSTSSSSSS-------R---------S---------V--GGGGAGTGGGKKRKKKLKKKIIYIFIIIFIEEPEAEQDAQSTTTTSTSTT

LLLLLLLLLLSSSTSSSSSSVSAAAAAAAADDDDDDDDEDFFFFYFFYFYTGGGIGTVTIHHRHDHHHHHTTTTTTTTTTFCCCFCFFFFFVVVMVFMFI----I---------H---------A---------P---------F---------K---------H---------S---------N---------A---------L---------H---------K---------R---------T---------D---------R---------I---------E---------L---------L---------T---------A---------E---------D---------L---------V---------N---------L---------I---------T---------A---------G---------L---------D---------G-----YYYYYYYYYYLLLLLLLLLLQQQQQQQQQQVTTTVTVVVVIAVI-ILIL-IIII-IIII-EDDD-DNTN-LLLLLLLLLLQ-----Q-Q-I-----I-I-R-----E-E-M-----M-M-F-----F-F-T-----T-T-K-----K-K-Q-----K-K-R-----R-R-Y-----Y---A-----A---R-----L-R-VVVVVVVVVVRRRRRRRRRRRQRQRQRRRRAEEEEESEAEPPPPPPPPPPVVVAVAIVVVRRRRRRRRRRYYYYAYYYYY---------QSSSSSSSSSS------R---------K---------K---------Q---------Y---------Y---------P---------M---------A---GSGKGRGGGGQQQQQQMQQQRRKRRRRRRRLLLLLLLLLLKKKKSKDKKKG-GGGGGGGGGGGDGGGGGG

TTTTTTTTTASTSSTSSSTSGGGGGGGGGGPPPPPPPPPPKEKKKKKKKGVTVVTVVVVVVVIVVVVVVVMMLMMLLLMIVVVVVVVVVIMMSSMMAAMLVVIVVVVIVVRRRRRRRRRRACEECEEEAEEEQEEEQQDEPPPPPPPPPPEEEEEEEEEEKKKKTKKKTKFFFFFFIFFFHNHHNQHHHHPPPPPPPPPPGGGGGGGGGGT-IT-TTITAF-FY-YFFFYK-MK-DMMKKG-LA-LLLALW-WW-WWWWWD-DD-DDEDDK-KK-KKKKKL-LL-ILLLLF-FF-FFFFFS-AD-SSSSSAEEEEEEEEELLLLLLLLLLQQQQQQQQQQ

DDDDDDDDDDTSSTSSTSTSRRRKRVRVRKKEMSEKRKKMYFYYYYYYYYKEEKEEKEKEDEKDEEDEDEEEEEEEEEEEKK-RKKRKR-VV-VVIVIV-TK-AKQAQA-DD-DDQDDD-SS-SSSSSS-FL-LILLLL-TT-TTTTTT-VI-IIIIII-ED-EDDDDD-SS-SDSSSI-VVVEVVEVEVRRRRRRRRRREEEEEEEEEERKVRRRRRRRFFFLFLLLLFHHHPHHAHPHPPPPPPPPPPASSSTSSASTPPPPPPPPPPHHHHHHHHHHGGGGGGGGGGNNNNNQMQNNVVVIVVIVIVVVIVVLVVIISSSSSSASSSMMMMLIMIMM

YYYYYYYYHYFFFFFFFFFF---------FSSPSPPPSSSQQQQQQQQQQRQMRMMMRMQYYLYLLLYLYRHRYRRRRRRKKKKKKKKKKGGGGGGGGGGKMKKKKKRKEPPPPPPPPPPKRRRKKKRRRINNINNNINNIIIIIIIIIISNSSSSSSASYYYYYYYLYYQQQQQQQQQQDDEDEEKDEDRRRRRRRRRRDDDDDDDDDGVVVAFIIVVVDDDDDGDDDDTTTTSTNTTT---------G---------VMLMLMMMMLLLILLIIISIIMLLMLLLLLLYFNYENNYNFLMQMQQQMMMMMMMMMMMMMIMLLIIILLMKKKKKKKKKKGGGGG-GGGGDDDDN-NDDDEEEET-EEEEEETEK-QEEE

NNNKNNNNKNASCAAACAACDEDEKDDKEDSSSSQSSQSSFFFFFFFFFFSSQSSSQNCQAVVVVAVIVVDDDDDDDDDDQQQQHQQQQQAEAEEEAEEAPPPPPPPPPPVAVVVVVVVVHHHHRHHRHQMILIIMLIILLLALMLALLSKRRRRKRRRRKQQQQQQQQAAGGGAAGAGGLIVIIIIIVIMMMMMMMMMMWWWWWWMWWMEEEEDEEDEELLLLLLLILLYYYYFYYFDYRRRNHRRRKRLLLLFLLFLLEESEEEDEEDEEEEEEDEEDNNNNNDNNNNTTKATKTTTTAAAAAAGAAGNQNNNNNNNNLLLLLLLLLLGGGGGGGGGGYFFFYYFYFFAAAAAAAAAAQQKQQQKQQK

A---------A---------T---------A---------G---------I---------A---------I---------R---------L---------S---------D---------KKKKKKKKKKLLLFLFLLLLDEEEEEPEEENDDDDDDDDDRRQRRRRRQREESEEEEESEMMMMMAMMMMRRRRRRRQRREEEDEDAAEEASAAAAAAAAAAAVAVAAAARRRRRRRRRTYYYHYHYYYYKKKNNNKSKRLLLLLLLLLLCCCCCCCCCCWWWLWLWWWWYFFFFFFFFFYVVYYYFYVYE--AAA---AD--DDD---DT---R----RT---K----TK---R----RL---LL---LL---VV---VV--VVV---VS--ASA---AI--LIL---IK--KKK---KE--EEE---ETTRTTKTTTTWWWWFWWWWWAATSSGSSTSMTTTTTSSTTLLLMKQIILLIVVVIAVVVIGGGKGKGGGGADDDDDEEDDTTTTTTTTTTVIIIIIMVLVAAAVAAAAAAEQEQEEEEEENNNRDNNNDDLLILLLLLILSEEEEQEEEE

YYFYYYYYYYMIIIIMIIMMLLLLLLLLLLLLALALLGLIPPRPPPPPPPDKKKKKKKEKFYYYYYYYYYNNNNNNNNNNWWYWWWWWWWKKKKKKKKKKLLLLLFLLLLNKNKNNKNNNSDDDEYDESDQQQQQQQQQQLLVLLLLLLLLLLLLLLLLL-D---------L---------L--------V-------V-D-------D-V-------V-TTSTSTTPTSAAGAAAAAMAEEEEEEEEEEQQQQKQQQQQKKKKRKKKKQGGGGGGGGGCYYYYYYYYYYEESDSDDTDDPPPPPPPPPPNQQQQDQQNNEEDEEEEEEEHHHHHHHHYHDDDDDDDDDDLLLLILLLLLYYYYYYYYYYIHQYRHHHIH---R---------F------KKKKKKKKKKHKTTTSTTHTLLVLVLLVLLEEEAQEEEEEPPPPPPPPPPCCTCTCCTSC