string: In addition, although Parkin KO mice do not recapitulate signs central to Parkinsonism, these mice are prone to cancer development (Fujiwara et al., 2008). Mice with homozygote Parkin exon 3 deletions spontaneously develop hepatic tumors with characteristics of hepatocellular carcinoma (HCC). Moreover, Parkin heterozygous deletion accompanied by APC heterozygous deletion promotes intestinal adenoma development in mice. As HCC appears in the mice at advanced age, and there is a dependency between Parkin and APC mutations in adenoma development, it is possible that a mutation in Parkin alone is not sufficient to initiate development of some types of cancer, and it may require additional risk factors. Moreover, we identified Parkin interacting proteins in melanoma cells by immunoprecipitation followed by mass spectrometry. The proteins detected are mainly connected to cell cycle, mitochondrial function, and proteasome function; this result is consistent with the study of Sarraf et al. (2013). In conclusion, our data indicate that Parkin has a tumor suppressive role in melanoma.