text: On the other hand, the antitumor effects of TNF- are mainly exerted on the tumor endothelium (25, 26), with increased permeability (17, 27, 28), up-regulation of tissue factor (29, 30), fibrin deposition, and thrombosis in the tumor vasculature, accompanied by a massive destruction of the endothelial cells (4, 5) that can be responsible for the antitumor response (26, 31–34).