passage-207
abstract
Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice.  Atopic dermatitis (AD) is a chronic inflammatory skin disease that commonly begins in childhood. K6PC-9p (N-(Ethyl dihydrogenphosphate)-2-hexyl-3-oxo-decanamide) is a synthetic ceramide derivative of PC-9S (N-Ethanol-2-mirystyl-3-oxo-staramide), which was known to be effective in atopic patients. In this study, we examined the effect of topical application of K6PC-9p on skin inflammation and AD-like skin lesions in mouse models. K6PC-9p dose-dependently inhibited phorbol ester-induced increase in ear thickness in BALB/c mice. Moreover, topical application of K6PC-9p suppressed dust mite extract-induced AD-like skin lesions in NC/Nga mice. Histopathological analysis revealed that both ear swelling and leucocyte infiltration were suppressed by K6PC-9p treatment. K6PC-9p also suppressed IL-4 and TNF-alpha expression in the ears and mast cell infiltration into the ears in NC/Nga mice. Further study demonstrated that K6PC-9p inhibited ConA-induced IL-4 secretion and LPS-induced macrophage activation. Taken together, our results showed that topical application of K6PC-9p exerts beneficial effects in animal model of skin inflammation and AD, suggesting that K6PC-9p might be a promising topical agent for the treatment of inflammatory skin diseases.
entity-207-0
DISEASE
atopic dermatitis-like skin lesions
entity-207-1
DISEASE
Atopic dermatitis
entity-207-2
DISEASE
AD
entity-207-3
DISEASE
chronic inflammatory skin disease
entity-207-4
DISEASE
skin inflammation
entity-207-5
DISEASE
AD-like skin lesions
entity-207-6
DISEASE
AD-like skin lesions
entity-207-7
DISEASE
ear swelling
entity-207-8
DISEASE
skin inflammation
entity-207-9
DISEASE
AD
entity-207-10
DISEASE
inflammatory skin diseases