passage-285
abstract
High-dose methylprednisolone in a pregnant woman with Crohn's disease and adrenal suppression in her newborn.  BACKGROUND: The synthetic corticosteroid methylprednisolone is used for the treatment of acute exacerbations of Crohn's disease, also in pregnancy. Its use is considered to be less harmful than the effect of active disease on the fetus. Adrenal suppression in a fetus due to administration of methylprednisolone has hitherto been rarely published. OBJECTIVE: To present a case of neonatal adrenal suppression due to the use of high-dose methylprednisolone in late pregnancy of a woman with Crohn's disease. METHODS AND RESULTS: Clinical signs of adrenal suppression were observed in the newborn 3 h after birth. After hydrocortisone supplementation and intensive therapy the baby recovered completely. CONCLUSIONS: Life-threatening adrenal suppression, requiring hydrocortisone supplementation and intensive therapy, was observed and successfully treated in a newborn, whose mother had received high-dose methylprednisolone in late pregnancy.
entity-285-0
DISEASE
Crohn's disease
entity-285-1
DISEASE
adrenal suppression
entity-285-2
DISEASE
Crohn's disease
entity-285-3
ADVERSE
Adrenal suppression
entity-285-4
ADVERSE
neonatal adrenal suppression
entity-285-5
DISEASE
Crohn's disease
entity-285-6
ADVERSE
adrenal suppression
entity-285-7
ADVERSE
adrenal suppression