passage-151
abstract
Acute interstitial nephritis due to deferasirox: a case report.  Deferasirox is a new oral iron chelator used to treat transfusional iron overload. Pre-marketing clinical trials revealed little organ-specific toxicity. Increases in serum creatinine were noted in one-third of patients but were mild and non-progressive. We describe a 62-year-old man with myelodysplastic syndrome who developed a progressive decline in renal function after starting deferasirox. A kidney biopsy showed acute interstitial nephritis with increased eosinophils, suggesting drug hypersensitivity. Deferasirox was discontinued and renal function returned to baseline. This is the first pathological description of deferasirox-related acute kidney injury in humans, which differs from tubular vacuolization observed in animals.
entity-151-0
ADVERSE
Acute interstitial nephritis
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DISEASE
transfusional iron overload
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ADVERSE
organ-specific toxicity
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DISEASE
myelodysplastic syndrome
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ADVERSE
progressive decline in renal function
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ADVERSE
acute interstitial nephritis
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ADVERSE
eosinophils
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ADVERSE
drug hypersensitivity
entity-151-8
ADVERSE
acute kidney injury