passages.id: IEPA.d56.s143
passages.text: Interleukin-1 beta inhibits phospholipase C and insulin secretion at sites apart from KATP channel
passages.id: IEPA.d56.s144
passages.text: Surprisingly, however, when islets were depolarized directly using either of two agonists, glyburide (which does not act via generation of purine nucleotides) or 40 mM K+ (which acts distal to KATP channel), PLC and insulin secretion were again obliterated by IL-1 beta
passages.id: IEPA.d56.s145
passages.text: These data (together with the finding that IL-1 beta inhibited Ca(2+)-induced insulin release) suggest that, in addition to its effects on ATP synthesis and thereby on the KATP channel, IL-1 beta has at least two undescribed, distal effects to block both PLC as well as Ca(2+)-induced exocytosis