passages.id: IEPA.d50.s127
passages.text: Insulin secretion is regulated by changes in blood glucose, as well as by peptides from the gastrointestinal tract and neurotransmitters that activate the pancreatic islet adenylyl cyclase (e.g., glucagon-like peptide-1) and phospholipase C (PLC) (e.g., acetylcholine) signaling pathways to further potentiate glucose-induced insulin secretion
passages.id: IEPA.d50.s128
passages.text: However, leptin did constrain the enhanced PLC-mediated insulin secretion characteristic of islets from ob/ob mice, without influencing release from islets of lean mice
passages.id: IEPA.d50.s129
passages.text: A specific enhancement in PLC-mediated insulin secretion is the earliest reported developmental alteration in insulin secretion from islets of ob/ob mice, and thus a logical target for leptin action
passages.id: IEPA.d50.s130
passages.text: This action of leptin on PLC-mediated insulin secretion was dose-dependent, rapid-onset (i.e., within 3 min), and reversible
passages.id: IEPA.d50.s131
passages.text: Leptin was equally effective in constraining the enhanced insulin release from islets of ob/ob mice caused by protein kinase C (PKC) activation, a downstream mediator of the PLC signal pathway
passages.id: IEPA.d50.s132
passages.text: One function of leptin in control of body composition is thus to target a PKC-regulated component of the PLC-PKC signaling system within islets to prevent hypersecretion of insulin