passages.id: IEPA.d145.s346
passages.text: Aggregated beta amyloid peptide 1-40 decreases Ca2+- and cholinergic receptor-mediated phosphoinositide degradation by alteration of membrane and cytosolic phospholipase C in brain cortex
passages.id: IEPA.d145.s347
passages.text: The effects of full-length amyloid beta protein, A(beta) (1-40), on phosphoinositide-specific phospholipase C (PLC) were investigated in synaptic plasma membranes (SPM) and cytosol prepared from the cerebral cortex of adult rats
passages.id: IEPA.d145.s348
passages.text: Aggregated A(beta) also decreased significantly the level of diacylglycerol, the product of PLC
passages.id: IEPA.d145.s349
passages.text: This additionally supports the inhibitory effect of A(beta) on membrane-bound and cytosolic PLC
passages.id: IEPA.d145.s350
passages.text: Moreover, A(beta) (1-40) significantly decreased the basal activity of the PIP2-PLC in SPM and the enzyme activity regulated through cholinergic receptors