passages.id: IEPA.d170.s410
passages.text: Influence of obesity and menopausal status on serum leptin, cholecystokinin, galanin and neuropeptide Y levels
passages.id: IEPA.d170.s411
passages.text: Obesity occurs in 60% of women after menopause and is characterized by an excess of adipose tissue that depends on several orexigenic (neuropeptide Y (NPY) stimulates carbohydrate ingestion, galanin stimulates fat intake) and anorectic (leptin, cholecystokinin (CCK)) factors
passages.id: IEPA.d170.s412
passages.text: Both leptin and insulin can reduce hypothalamic NPY production and secretion
passages.id: IEPA.d170.s413
passages.text: We investigated basal levels of serum leptin, CCK, galanin and NPY in 16 non-obese premenopausal women, in 15 obese premenopausal women (body mass index (BMI) 34.6 +/- 1.3 SD) and in ten obese postmenopausal women (BMI 34.7 +/- 1.5 SD) to determine the relationship between obesity, menopause and these neuropeptides
passages.id: IEPA.d170.s414
passages.text: Significantly increased leptin and galanin levels in postmenopausal obese women coupled with decreased NPY levels revealed some changes in the neuropeptides regulating eating behavior, which may be the reason for the onset of postmenopausal obesity