passages.id: IEPA.d42.s103
passages.text: Signal transduction in pancreatic beta-cells: Regulation of insulin secretion by information flow in the phospholipase C/Protein kinase C pathway
passages.id: IEPA.d42.s104
passages.text: The physiologic regulation of glucose-induced insulin secretion is dependent upon the activation of information flow in the phospholipase C (PLC)/protein kinase C (PKC) signal transduction system
passages.id: IEPA.d42.s105
passages.text: When rat islet are cultured for short periods, the content and activation of PLC in response to glucose decreases and this biochemical defect in signal transduction is paralleled by significant reductions in glucose-induced insulin secretion
passages.id: IEPA.d42.s106
passages.text: Biphasic insulin secretion can be evoked and time-dependent potentiation can be induced in mouse islets by carbachol, an agonist that activates an isozyme of PLC distinct from that activated by glucose
passages.id: IEPA.d42.s107
passages.text: When taken in their entirety, the experimental evidence suggests that the activation of PLC is an essential component in the physiologic regulation of insulin secretion and that disordered activation of the enzyme culminates in disordered insulin release