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NPY-leptin: opposing effects on appetitive and consummatory ingestive behavior and sexual behavior
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Many studies have indicated that neuropeptide Y (NPY) stimulates and leptin inhibits food intake
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In line with this, intracerebroventricular injection of NPY (10 microg) stimulated and leptin (10 microg) inhibited intake of a sucrose solution when female rats were required to obtain the solution from a bottle
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However, NPY inhibited and leptin stimulated intake if the solution was infused intraorally
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Thus NPY stimulates the responses used to obtain food but inhibits those used to consume food, and leptin has the opposite effects