IEPA.d190.s454
Leptin effects on pulsatile gonadotropin releasing hormone secretion from the adult rat hypothalamus and interaction with cocaine and amphetamine regulated transcript peptide and neuropeptide Y [In Process Citation]
IEPA.d190.s455
Leptin may act as a negative feedback signal to the hypothalamic control of appetite through suppression of neuropeptide Y (NPY) secretion and stimulation of cocaine and amphetamine regulated transcript (CART).
IEPA.d190.s456
We aimed at studying the effects of leptin, CART and NPY on the hypothalamic control of the pituitary-gonadal system.
IEPA.d190.s457
The increase in GnRH pulse amplitude caused by leptin was totally prevented by coincubation with an anti-CART antiserum whereas it was not affected by coincubation with the NPY Y5-receptor antagonist (10(-7) M).
IEPA.d190.s458
In conclusion, leptin and NPY show separate permissive effects on GnRH secretion in the adult rat hypothalamus.