IEPA.d180.s431
A loop system exists between hypothalamic neuropeptide Y (NPY) and peripheral adipose tissue leptin to maintain normal body homeostasis
IEPA.d180.s432
When infused i.c.v. to normal rats to mimic its central effects, leptin decreases NPY levels, thus food intake and body weight
IEPA.d180.s433
Circadian fluctuations of NPY and leptin levels maintain normal body homeostasis
IEPA.d180.s434
Leptin increases the expression of uncoupling proteins (UCP-1, -2, -3) and thus energy dissipation