IEPA.d24.s48
The aim of the present study was to investigate how oxytocin given subcutaneously (SC) and intracerebroventricularly (ICV) influences the secretion of insulin, glucagon and glucose and to investigate whether the effect on these variables of suckling in lactating rats is mediated by oxytocinergic mechanisms
IEPA.d24.s49
Subcutaneous injections of oxytocin increased insulin, glucagon and glucose levels significantly
IEPA.d24.s50
Two nanograms oxytocin given ICV had no effect on glucagon and glucose levels but caused a significant rise in insulin levels at this time point
IEPA.d24.s51
The oxytocin antagonist 1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Orn-oxytocin administered ICV increased insulin levels itself and therefore the effect on oxytocin-induced insulin secretion was difficult to evaluate
IEPA.d24.s52
Intracerebroventricular injections of 200 ng oxytocin caused a significant rise not only of insulin but also of glucagon and glucose levels
IEPA.d24.s53
In contrast, nanogram amounts of oxytocin administered ICV cause a rise of insulin levels