IEPA.d65.s163
Vasopressin-induced activation of protein kinase C in renal epithelial cells
IEPA.d65.s164
AVP induced a biphasic increase in diacylglycerol generation, characterized by an initial rapid rise and then a sustained elevation, and PKC activation, reflected by phosphorylation of a specific 80 kDa myristoylated alanine-rich PKC substrate (MARCKS)
IEPA.d65.s165
These results argue that Ca(2+)-dependent PKC is involved in the action of AVP, and that of other agonists, which stimulate sodium transport