IEPA.d48.s123
Leptin increases uncoupling protein expression and energy expenditure
IEPA.d48.s124
Leptin increased BAT UCP mRNA levels greater than twofold in both ad libitum-fed and food-restricted rats
IEPA.d48.s125
These data demonstrate a leptin-induced increase in energy expenditure in nonmutant rodents and suggest that one mechanism by which leptin increases energy expenditure is through increased thermogenesis in BAT, including increased expression of UCP