IEPA.d11.s23
Amyloid beta protein (25-35) stimulation of phospholipases A, C and D activities of LA-N-2 cells
IEPA.d11.s24
[3H]Inositol prelabeled LA-N-2 cells were exposed to varying concentrations of A beta P, from 20 to 125 micrograms/ml, and phospholipase C activation was measured
IEPA.d11.s25
The effects of adrenergic, metabotropic amino acid and bombesin antagonists on the A beta P mediated stimulation of phospholipase C activity was investigated
IEPA.d11.s26
Propranolol, a beta adrenergic antagonist, 7-chloro-kynurenic acid, a metabotropic amino acid antagonist, and [Tyr4-D-Phe12]bombesin, a bombesin antagonist, blunted the A beta P stimulation of phospholipase C activity in [3H]inositol prelabeled LA-N-2 cells
IEPA.d11.s27
This suggests that amyloid beta protein activation of phospholipase C may be receptor mediated
IEPA.d11.s28
The phospholipase C inhibitor U 71322 prevented the activation of phospholipase C by A beta P