IEPA.d150.s363
Possible central nervous system (CNS) mechanisms could mediate these responses in that leptin receptors are located on hypothalamic neurons that coexpress neuropeptide-Y (NPY) or proopiomelanocortin (POMC) and both peptides that have been implicated as mediators of the CNS action of leptin.
IEPA.d150.s364
Leptin has been demonstrated to decrease or down regulate NPY expression and increase POMC expression