IEPA.d165.s397
Interactions between leptin and NPY affecting lipid mobilization in adipose tissue
IEPA.d165.s398
The aim of the current investigations was focused on the study of the involvement of leptin and neuropeptide Y in lipid mobilization
IEPA.d165.s399
The lipolytic rate was assessed through glycerol release after incubation with leptin and NPY at concentrations ranging from 10(-6) to 10(-12) M in isolated adipocytes obtained from female rats
IEPA.d165.s400
At equimolar concentrations of leptin and NPY (10(-12) to 10(-6) M) the observed lipolytic activity is comparable to the basal lipolytic activity, except at a concentration of 10(-9) M where upon a significant increase in lipolysis is observed
IEPA.d165.s401
Summing up, new evidence suggests that NPY and leptin may interact in a homeostatic loop to regulate body-fat mass and energy balance not only at the central nervous system level, but also directly at the adipocyte level