sentences.id: IEPA.d20.s42
sentences.origID: 414
sentences.text: We propose that OT binds to specific OT receptors (OTR) on the endometrium to stimulate phosphoinositide (PI) hydrolysis, thereby activating the inositol trisphosphate (IP3)-diacylglycerol (DAG) second-messenger system to promote pulsatile PGF2 alpha secretion
sentences.id: IEPA.d20.s42.e0
sentences.origID: 939
sentences.text: OT
sentences.id: IEPA.d20.s42.e1
sentences.origID: 940
sentences.text: IP3
sentences.id: IEPA.d20.s42.i0
sentences.e1: IEPA.d20.s42.e0
sentences.e2: IEPA.d20.s42.e1
sentences.type: PPI
sentences.id: IEPA.d20.s43
sentences.origID: 415
sentences.text: Endometrial IP3 was increased within 30 seconds after OT treatment and preceded the increase in PGF2 alpha release stimulated by OT
sentences.id: IEPA.d20.s43.e0
sentences.origID: 941
sentences.text: IP3
sentences.id: IEPA.d20.s43.e1
sentences.origID: 942
sentences.text: OT
sentences.id: IEPA.d20.s43.e2
sentences.origID: 943
sentences.text: OT
sentences.id: IEPA.d20.s43.i0
sentences.e1: IEPA.d20.s43.e0
sentences.e2: IEPA.d20.s43.e1
sentences.type: PPI
sentences.id: IEPA.d20.s44
sentences.origID: 416
sentences.text: These results support the hypothesis that OT stimulates phospholipase C to hydrolyze PI, yielding IP3 and DAG second-messengers which promote endometrial PGF2 alpha release during CL regression in pigs
sentences.id: IEPA.d20.s44.e0
sentences.origID: 944
sentences.text: OT
sentences.id: IEPA.d20.s44.e1
sentences.origID: 945
sentences.text: IP3
sentences.id: IEPA.d20.s44.i0
sentences.e1: IEPA.d20.s44.e0
sentences.e2: IEPA.d20.s44.e1
sentences.type: PPI