sentences.id: IEPA.d8.s14
sentences.origID: 399
sentences.text: The objectives of this study were to evaluate and compare the actions of endothelin-1 (ET-1), oxytocin, prostaglandin F2 alpha (PGF2 alpha) and inositol 1,4,5-trisphosphate (IP3) on 45Ca2+ mobilization in permeabilized rat myometrial cells and to examine the activation of the inositol lipid cycle in intact myocytes
sentences.id: IEPA.d8.s14.e0
sentences.origID: 906
sentences.text: oxytocin
sentences.id: IEPA.d8.s14.e1
sentences.origID: 907
sentences.text: inositol 1,4,5-trisphosphate
sentences.id: IEPA.d8.s15
sentences.origID: 400
sentences.text: All four agonists caused a biphasic release of 45Ca2+ from non-mitochondrial pool(s), with the rank order of potency: oxytocin > PGF2 alpha > ET-1 > IP3
sentences.id: IEPA.d8.s15.e0
sentences.origID: 908
sentences.text: oxytocin
sentences.id: IEPA.d8.s15.e1
sentences.origID: 909
sentences.text: IP3
sentences.id: IEPA.d8.s16
sentences.origID: 401
sentences.text: Endothelin-1 and oxytocin stimulated inositol phosphate accumulation at concentrations similar to those that promoted 45Ca2+ efflux, whereas about 100 times higher concentrations of PGF2 alpha were needed to activate this signaling pathway in intact cells
sentences.id: IEPA.d8.s16.e0
sentences.origID: 910
sentences.text: oxytocin
sentences.id: IEPA.d8.s16.e1
sentences.origID: 911
sentences.text: inositol phosphate
sentences.id: IEPA.d8.s16.i0
sentences.e1: IEPA.d8.s16.e0
sentences.e2: IEPA.d8.s16.e1
sentences.type: PPI
sentences.id: IEPA.d8.s17
sentences.origID: 402
sentences.text: It is concluded that the primary action of PGF2 alpha in myometrial cells is to enhance Ca2+ influx, whereas oxytocin and ET-1 receptors are coupled to phospholipase C, generating IP3 and raising the intracellular concentration of free Ca2+ from intracellular as well as extracellular sources
sentences.id: IEPA.d8.s17.e0
sentences.origID: 912
sentences.text: oxytocin
sentences.id: IEPA.d8.s17.e1
sentences.origID: 913
sentences.text: IP3
sentences.id: IEPA.d8.s17.i0
sentences.e1: IEPA.d8.s17.e0
sentences.e2: IEPA.d8.s17.e1
sentences.type: PPI