sentences.id: IEPA.d172.s416
sentences.origID: 21
sentences.text: Therefore, it was examined whether stimulation of Swiss 3T3 cells with insulin causes changes in the subcellular distribution of EGF receptors and phospholipase Cgamma1 that could potentially explain the observed synergy or costimulation.
sentences.id: IEPA.d172.s416.e0
sentences.origID: 50
sentences.text: insulin
sentences.id: IEPA.d172.s416.e1
sentences.origID: 51
sentences.text: phospholipase Cgamma1
sentences.id: IEPA.d172.s416.i0
sentences.e1: IEPA.d172.s416.e0
sentences.e2: IEPA.d172.s416.e1
sentences.type: PPI
sentences.id: IEPA.d172.s417
sentences.origID: 22
sentences.text: However, both EGF and insulin stimulated the accumulation of phospholipase Cgamma1 at the actin arc, which was coincident with the EGF receptor in the case of insulin- stimulated cells.
sentences.id: IEPA.d172.s417.e0
sentences.origID: 52
sentences.text: insulin
sentences.id: IEPA.d172.s417.e1
sentences.origID: 53
sentences.text: phospholipase Cgamma1
sentences.id: IEPA.d172.s417.e2
sentences.origID: 54
sentences.text: insulin
sentences.id: IEPA.d172.s417.i0
sentences.e1: IEPA.d172.s417.e0
sentences.e2: IEPA.d172.s417.e1
sentences.type: PPI
sentences.id: IEPA.d172.s418
sentences.origID: 23
sentences.text: Therefore, it is suggested that the insulin-induced coclustering of the EGF receptor with phospholipase Cgamma1 at the actin arc may allow for greater efficiency of signal transduction, resulting in the synergy observed for these two hormones in stimulation of DNA synthesis.
sentences.id: IEPA.d172.s418.e0
sentences.origID: 55
sentences.text: insulin
sentences.id: IEPA.d172.s418.e1
sentences.origID: 56
sentences.text: phospholipase Cgamma1
sentences.id: IEPA.d172.s418.i0
sentences.e1: IEPA.d172.s418.e0
sentences.e2: IEPA.d172.s418.e1
sentences.type: PPI