sentences.id: IEPA.d57.s146
sentences.origID: 62
sentences.text: Activation of EGFR overexpressing 3T3-L1 adipocytes leads to a 3.4 +/- 1.2-fold stimulation of PLC activity over basal levels vs. only 1.06 +/- 0.01-fold stimulation by insulin.
sentences.id: IEPA.d57.s146.e0
sentences.origID: 139
sentences.text: PLC
sentences.id: IEPA.d57.s146.e1
sentences.origID: 140
sentences.text: insulin
sentences.id: IEPA.d57.s146.i0
sentences.e1: IEPA.d57.s146.e0
sentences.e2: IEPA.d57.s146.e1
sentences.type: PPI
sentences.id: IEPA.d57.s147
sentences.origID: 63
sentences.text: Despite the low levels of insulin-induced PLC activity, insulin-stimulated glucose transport activity was similarly inhibited by U73122 (55.9 +/- 13.1% inhibition)
sentences.id: IEPA.d57.s147.e0
sentences.origID: 141
sentences.text: insulin
sentences.id: IEPA.d57.s147.e1
sentences.origID: 142
sentences.text: PLC
sentences.id: IEPA.d57.s147.e2
sentences.origID: 143
sentences.text: insulin
sentences.id: IEPA.d57.s147.i0
sentences.e1: IEPA.d57.s147.e0
sentences.e2: IEPA.d57.s147.e1
sentences.type: PPI
sentences.id: IEPA.d57.s148
sentences.origID: 64
sentences.text: Inhibition of PLC activation did not impair either EGF- or insulin-induced activation of glycogen synthase or incorporation of glucose into lipid, supporting the hypothesis that both EGF- and insulin-induced glucose disposal can be independent of GLUT4-mediated glucose transport.
sentences.id: IEPA.d57.s148.e0
sentences.origID: 144
sentences.text: PLC
sentences.id: IEPA.d57.s148.e1
sentences.origID: 145
sentences.text: insulin
sentences.id: IEPA.d57.s148.e2
sentences.origID: 146
sentences.text: insulin
sentences.id: IEPA.d57.s149
sentences.origID: 65
sentences.text: The diminution of glucose transport secondary to inhibition of PLC activity was reflected by a decrease in GLUT4 translocation to the plasma membrane upon either EGF or insulin stimulation
sentences.id: IEPA.d57.s149.e0
sentences.origID: 147
sentences.text: PLC
sentences.id: IEPA.d57.s149.e1
sentences.origID: 148
sentences.text: insulin