sentences.id: IEPA.d197.s478
sentences.origID: 1
sentences.text: Bovine prion protein as a modulator of protein kinase CK2
sentences.id: IEPA.d197.s478.e0
sentences.origID: 1
sentences.text: Bovine prion protein
sentences.id: IEPA.d197.s478.e1
sentences.origID: 2
sentences.text: protein kinase CK2
sentences.id: IEPA.d197.s478.i0
sentences.e1: IEPA.d197.s478.e0
sentences.e2: IEPA.d197.s478.e1
sentences.type: PPI
sentences.id: IEPA.d197.s479
sentences.origID: 2
sentences.text: On the basis of far-Western blot and plasmon resonance (BIAcore) experiments, we show here that recombinant bovine prion protein (bPrP) (25-242) strongly interacts with the catalytic alpha/alpha' subunits of protein kinase CK2 (also termed 'casein kinase 2')
sentences.id: IEPA.d197.s479.e0
sentences.origID: 3
sentences.text: bovine prion protein
sentences.id: IEPA.d197.s479.e1
sentences.origID: 4
sentences.text: protein kinase CK2
sentences.id: IEPA.d197.s479.i0
sentences.e1: IEPA.d197.s479.e0
sentences.e2: IEPA.d197.s479.e1
sentences.type: PPI
sentences.id: IEPA.d197.s480
sentences.origID: 3
sentences.text: We also show that bPrP counteracts the inhibition of calmodulin phosphorylation promoted by the regulatory beta subunits of CK2
sentences.id: IEPA.d197.s480.e0
sentences.origID: 5
sentences.text: bPrP
sentences.id: IEPA.d197.s480.e1
sentences.origID: 6
sentences.text: CK2
sentences.id: IEPA.d197.s481
sentences.origID: 4
sentences.text: A truncated form of bPrP encompassing the C-terminal domain (residues 105-242) interacts with CK2 but does not affect its catalytic activity
sentences.id: IEPA.d197.s481.e0
sentences.origID: 7
sentences.text: bPrP
sentences.id: IEPA.d197.s481.e1
sentences.origID: 8
sentences.text: CK2
sentences.id: IEPA.d197.s481.i0
sentences.e1: IEPA.d197.s481.e0
sentences.e2: IEPA.d197.s481.e1
sentences.type: PPI
sentences.id: IEPA.d197.s482
sentences.origID: 5
sentences.text: These results disclose the potential of the PrP to modulate the activity of CK2, a pleiotropic protein kinase that is particularly abundant in the brain
sentences.id: IEPA.d197.s482.e0
sentences.origID: 9
sentences.text: PrP
sentences.id: IEPA.d197.s482.e1
sentences.origID: 10
sentences.text: CK2
sentences.id: IEPA.d197.s482.e2
sentences.origID: 11
sentences.text: protein kinase
sentences.id: IEPA.d197.s482.i0
sentences.e1: IEPA.d197.s482.e0
sentences.e2: IEPA.d197.s482.e1
sentences.type: PPI