sentences.id: IEPA.d161.s386
sentences.origID: 306
sentences.text: Induction of fatty acid translocase/CD36, peroxisome proliferator-activated receptor-gamma2, leptin, uncoupling proteins 2 and 3, and tumor necrosis factor-alpha gene expression in human subcutaneous fat by lipid infusion
sentences.id: IEPA.d161.s386.e0
sentences.origID: 672
sentences.text: leptin
sentences.id: IEPA.d161.s386.e1
sentences.origID: 673
sentences.text: uncoupling proteins 2
sentences.id: IEPA.d161.s386.e2
sentences.origID: 674
sentences.text: 3
sentences.id: IEPA.d161.s387
sentences.origID: 307
sentences.text: Using reverse transcriptase-polymerase chain reaction analysis, the mRNA expression of fatty acid translocase (FAT)/CD36, PPAR-gamma2, leptin, uncoupling protein (UCP)-2 and UCP-3, and tumor necrosis factor (TNF)-alpha was investigated in gluteal subcutaneous fat biopsies before and after 5 h infusions of saline or Intralipid (Pharmacia and Upjohn, Milan, Italy) plus heparin, which does not modify insulinemia
sentences.id: IEPA.d161.s387.e0
sentences.origID: 675
sentences.text: leptin
sentences.id: IEPA.d161.s387.e1
sentences.origID: 676
sentences.text: uncoupling protein (UCP)-2
sentences.id: IEPA.d161.s387.e2
sentences.origID: 677
sentences.text: UCP-3
sentences.id: IEPA.d161.s388
sentences.origID: 308
sentences.text: Marked increases in FAT/CD36 (724+/-18%; P < 0.05), PPAR-gamma2 (200+/-8%; P < 0.05), leptin (110+/-13%; P < 0.05), UCP-2 (120+/-7%; P < 0.05), UCP-3 (80+/-5%; P < 0.05), and TNF-alpha mRNA (130+/-12%; P < 0.05) were observed in comparison with pretreatment levels, whereas there was no change after saline infusion
sentences.id: IEPA.d161.s388.e0
sentences.origID: 678
sentences.text: leptin
sentences.id: IEPA.d161.s388.e1
sentences.origID: 679
sentences.text: UCP-2
sentences.id: IEPA.d161.s388.e2
sentences.origID: 680
sentences.text: UCP-3
sentences.id: IEPA.d161.s389
sentences.origID: 309
sentences.text: These data suggest that the in vivo gene expression of FAT/CD36, PPAR-gamma2, leptin, UCP-2, UCP-3, and TNF-alpha in subcutaneous adipose tissue is regulated by circulating lipids independent of insulin and that prolonged hyperlipidemia may therefore contribute to increased fat metabolism and storage as a result of the increased expression of these proteins
sentences.id: IEPA.d161.s389.e0
sentences.origID: 681
sentences.text: leptin
sentences.id: IEPA.d161.s389.e1
sentences.origID: 682
sentences.text: UCP-2
sentences.id: IEPA.d161.s389.e2
sentences.origID: 683
sentences.text: UCP-3