sentences.id: IEPA.d196.s476
sentences.origID: 130
sentences.text: Both receive information about the nutritional status and the level of energy storage through insulin and leptin signaling mediated by specific receptors located on POMC and NPY neurons present predominantly in the arcuate nucleus (ARC).
sentences.id: IEPA.d196.s476.e0
sentences.origID: 291
sentences.text: leptin
sentences.id: IEPA.d196.s476.e1
sentences.origID: 292
sentences.text: NPY
sentences.id: IEPA.d196.s477
sentences.origID: 131
sentences.text: When leptin signaling is defective, through a defect in either the receptor (Zucker fa/fa rat, cp/cp rat, and db/db mouse) or in the peptide itself (ob/ob mouse), the NPY system is upregulated as shown by mRNA overexpression and increased peptide release, whereas the content and/or release of some inhibitory peptides (neurotensin, cholecystokinin) are diminished.
sentences.id: IEPA.d196.s477.e0
sentences.origID: 293
sentences.text: leptin
sentences.id: IEPA.d196.s477.e1
sentences.origID: 294
sentences.text: NPY