sentences.id: IEPA.d114.s274
sentences.origID: 333
sentences.text: In normal pancreatic islets, UCP-2 is upregulated by leptin and is low in leptin-resistant islets of ZDF rats
sentences.id: IEPA.d114.s274.e0
sentences.origID: 746
sentences.text: UCP-2
sentences.id: IEPA.d114.s274.e1
sentences.origID: 747
sentences.text: leptin
sentences.id: IEPA.d114.s274.e2
sentences.origID: 748
sentences.text: leptin
sentences.id: IEPA.d114.s274.i0
sentences.e1: IEPA.d114.s274.e0
sentences.e2: IEPA.d114.s274.e1
sentences.type: PPI
sentences.id: IEPA.d114.s275
sentences.origID: 334
sentences.text: To determine whether UCP-2 does, in fact, have uncoupling activity and, if so, whether such activity would favorably influence the abnormalities in leptin-unresponsive UCP-2-underexpressing islets of diabetic ZDF rats, we transferred the UCP-2 gene to the islets of diabetic ZDF rats and lean (+/+) ZDF control rats
sentences.id: IEPA.d114.s275.e0
sentences.origID: 749
sentences.text: UCP-2
sentences.id: IEPA.d114.s275.e1
sentences.origID: 750
sentences.text: leptin
sentences.id: IEPA.d114.s275.e2
sentences.origID: 751
sentences.text: UCP-2
sentences.id: IEPA.d114.s275.e3
sentences.origID: 752
sentences.text: UCP-2
sentences.id: IEPA.d114.s276
sentences.origID: 335
sentences.text: We conclude that UCP-2 has uncoupling function when overexpressed in leptin-insensitive islets and that its overexpression corrects the underexpression of the insulin gene and ameliorates glucose-stimulated insulin secretion, possibly by increasing the ATP:ADP ratio
sentences.id: IEPA.d114.s276.e0
sentences.origID: 753
sentences.text: UCP-2
sentences.id: IEPA.d114.s276.e1
sentences.origID: 754
sentences.text: leptin