sentences.id: IEPA.d33.s71
sentences.origID: 385
sentences.text: Correlation between the stimulatory effect of oxytocin on the formation of inositol phosphates and the oxytocin receptor level in the pregnant rabbit myometrium
sentences.id: IEPA.d33.s71.e0
sentences.origID: 878
sentences.text: oxytocin
sentences.id: IEPA.d33.s71.e1
sentences.origID: 879
sentences.text: inositol phosphates
sentences.id: IEPA.d33.s71.i0
sentences.e1: IEPA.d33.s71.e0
sentences.e2: IEPA.d33.s71.e1
sentences.type: PPI
sentences.id: IEPA.d33.s72
sentences.origID: 386
sentences.text: OBJECTIVE: In order to elucidate the roles of inositol trisphosphate (IP3) and oxytocin (OT) receptors in rabbit parturition, the concentration of IP3 induced by OT and the OT receptor levels were determined in rabbit myometria before and after parturition
sentences.id: IEPA.d33.s72.e0
sentences.origID: 880
sentences.text: inositol trisphosphate
sentences.id: IEPA.d33.s72.e1
sentences.origID: 881
sentences.text: IP3
sentences.id: IEPA.d33.s72.e2
sentences.origID: 882
sentences.text: OT
sentences.id: IEPA.d33.s72.i0
sentences.e1: IEPA.d33.s72.e1
sentences.e2: IEPA.d33.s72.e2
sentences.type: PPI
sentences.id: IEPA.d33.s73
sentences.origID: 387
sentences.text: METHODS: The effects of OT on IP3 formation and OT receptor levels were determined in the myometria of non-pregnant rabbits, Days 26, 28 and 30 of pregnancy rabbits, postpartum rabbits within 12 hours and steroid-treated ovariectomized rabbits
sentences.id: IEPA.d33.s73.e0
sentences.origID: 883
sentences.text: OT
sentences.id: IEPA.d33.s73.e1
sentences.origID: 884
sentences.text: IP3
sentences.id: IEPA.d33.s74
sentences.origID: 388
sentences.text: RESULTS: OT receptors were not detectable in the myometria of non-pregnant rabbits, and OT had no effect on the formation of inositol phosphates (IPs)
sentences.id: IEPA.d33.s74.e0
sentences.origID: 885
sentences.text: OT
sentences.id: IEPA.d33.s74.e1
sentences.origID: 886
sentences.text: inositol phosphates
sentences.id: IEPA.d33.s74.i0
sentences.e1: IEPA.d33.s74.e0
sentences.e2: IEPA.d33.s74.e1
sentences.type: PPI
sentences.id: IEPA.d33.s75
sentences.origID: 389
sentences.text: On Day 28 of pregnancy, OT receptors became detectable, and then OT could induce the formation of IPs
sentences.id: IEPA.d33.s75.e0
sentences.origID: 887
sentences.text: OT
sentences.id: IEPA.d33.s75.e1
sentences.origID: 888
sentences.text: IPs
sentences.id: IEPA.d33.s75.i0
sentences.e1: IEPA.d33.s75.e0
sentences.e2: IEPA.d33.s75.e1
sentences.type: PPI
sentences.id: IEPA.d33.s76
sentences.origID: 390
sentences.text: Thereafter, the stimulatory effects of OT on IPs formation and the OT receptor levels dramatically increased toward the end of pregnancy and reduced rapidly after parturition
sentences.id: IEPA.d33.s76.e0
sentences.origID: 889
sentences.text: OT
sentences.id: IEPA.d33.s76.e1
sentences.origID: 890
sentences.text: IPs
sentences.id: IEPA.d33.s76.i0
sentences.e1: IEPA.d33.s76.e0
sentences.e2: IEPA.d33.s76.e1
sentences.type: PPI
sentences.id: IEPA.d33.s77
sentences.origID: 391
sentences.text: When the ovariectomized pregnant rabbits were treated with estrogen, OT receptors in the myometrium were induced, and OT acquired the ability to stimulate IP3 formation
sentences.id: IEPA.d33.s77.e0
sentences.origID: 891
sentences.text: OT
sentences.id: IEPA.d33.s77.e1
sentences.origID: 892
sentences.text: IP3
sentences.id: IEPA.d33.s77.i0
sentences.e1: IEPA.d33.s77.e0
sentences.e2: IEPA.d33.s77.e1
sentences.type: PPI
sentences.id: IEPA.d33.s78
sentences.origID: 392
sentences.text: In addition, an OT receptor antagonist inhibited the stimulatory effects of OT on IP3 formation
sentences.id: IEPA.d33.s78.e0
sentences.origID: 893
sentences.text: OT
sentences.id: IEPA.d33.s78.e1
sentences.origID: 894
sentences.text: IP3
sentences.id: IEPA.d33.s78.i0
sentences.e1: IEPA.d33.s78.e0
sentences.e2: IEPA.d33.s78.e1
sentences.type: PPI
sentences.id: IEPA.d33.s79
sentences.origID: 498
sentences.text: CONCLUSIONS: These results suggest that the formation of IPs by OT, the OT receptor levels in the myometrium, and the production of PGF2 in the decidua might play crucial roles in parturition
sentences.id: IEPA.d33.s79.e0
sentences.origID: 895
sentences.text: IPs
sentences.id: IEPA.d33.s79.e1
sentences.origID: 896
sentences.text: OT
sentences.id: IEPA.d33.s79.i0
sentences.e1: IEPA.d33.s79.e0
sentences.e2: IEPA.d33.s79.e1
sentences.type: PPI