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Leptin Rapidly Inhibits Hypothalamic Neuropeptide Y Secretion and Stimulates Corticotropin-Releasing Hormone Secretion in Adrenalectomized Mice
IEPA.d195.s469.e0
295
Leptin
IEPA.d195.s469.e1
296
Neuropeptide Y
IEPA.d195.s469.i0
IEPA.d195.s469.e0
IEPA.d195.s469.e1
PPI
IEPA.d195.s470
133
Leptin may rapidly inhibit food intake by altering the secretion of hypothalamic neuropeptides such as neuropeptide Y (NPY), a stimulator of food intake, and/or corticotropin-releasing hormone (CRH), an inhibitor of food intake
IEPA.d195.s470.e0
297
Leptin
IEPA.d195.s470.e1
298
neuropeptide Y
IEPA.d195.s470.i0
IEPA.d195.s470.e0
IEPA.d195.s470.e1
PPI
IEPA.d195.s471
134
We measured concentrations of NPY and CRH in specific hypothalamic regions [i.e., arcuate nucleus (ARC), paraventricular nucleus (PVN), ventromedial nucleus and dorsomedial nucleus] of 7- to 8-wk-old lean and ob/ob mice at 1 or 3 h after intracerebroventricular leptin administration
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299
NPY
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300
leptin
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135
No rapid-onset effects of leptin on hypothalamic NPY or CRH concentrations were observed in intact mice
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leptin
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302
NPY
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136
The addition of leptin to hypothalamic preparations from intact mice also did not alter NPY or CRH secretion
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leptin
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304
NPY
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137
Within 20 min after exposure to leptin, NPY secretion from hypothalamic preparations obtained from adrenalectomized mice was lowered by 27% and CRH secretion was elevated by 51%
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leptin
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306
NPY
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PPI
IEPA.d195.s475
138
The current study demonstrates that leptin rapidly influences the secretion of hypothalamic NPY and CRH and that these actions of leptin within the hypothalamus are restrained by the presence of endogenous corticosterone
IEPA.d195.s475.e0
307
leptin
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308
NPY
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309
leptin
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PPI