IEPA.d145.s346
262
Aggregated beta amyloid peptide 1-40 decreases Ca2+- and cholinergic receptor-mediated phosphoinositide degradation by alteration of membrane and cytosolic phospholipase C in brain cortex
IEPA.d145.s346.e0
571
amyloid
IEPA.d145.s346.e1
572
phospholipase C
IEPA.d145.s346.i0
IEPA.d145.s346.e0
IEPA.d145.s346.e1
PPI
IEPA.d145.s347
263
The effects of full-length amyloid beta protein, A(beta) (1-40), on phosphoinositide-specific phospholipase C (PLC) were investigated in synaptic plasma membranes (SPM) and cytosol prepared from the cerebral cortex of adult rats
IEPA.d145.s347.e0
573
amyloid
IEPA.d145.s347.e1
574
phospholipase C
IEPA.d145.s348
264
Aggregated A(beta) also decreased significantly the level of diacylglycerol, the product of PLC
IEPA.d145.s348.e0
575
A(beta)
IEPA.d145.s348.e1
576
PLC
IEPA.d145.s349
265
This additionally supports the inhibitory effect of A(beta) on membrane-bound and cytosolic PLC
IEPA.d145.s349.e0
577
A(beta)
IEPA.d145.s349.e1
578
PLC
IEPA.d145.s349.i0
IEPA.d145.s349.e0
IEPA.d145.s349.e1
PPI
IEPA.d145.s350
266
Moreover, A(beta) (1-40) significantly decreased the basal activity of the PIP2-PLC in SPM and the enzyme activity regulated through cholinergic receptors
IEPA.d145.s350.e0
579
A(beta) (1-40)
IEPA.d145.s350.e1
580
PIP2-PLC
IEPA.d145.s350.i0
IEPA.d145.s350.e0
IEPA.d145.s350.e1
PPI