IEPA.d145.s346
Aggregated beta amyloid peptide 1-40 decreases Ca2+- and cholinergic receptor-mediated phosphoinositide degradation by alteration of membrane and cytosolic phospholipase C in brain cortex
IEPA.d145.s347
The effects of full-length amyloid beta protein, A(beta) (1-40), on phosphoinositide-specific phospholipase C (PLC) were investigated in synaptic plasma membranes (SPM) and cytosol prepared from the cerebral cortex of adult rats
IEPA.d145.s348
Aggregated A(beta) also decreased significantly the level of diacylglycerol, the product of PLC
IEPA.d145.s349
This additionally supports the inhibitory effect of A(beta) on membrane-bound and cytosolic PLC
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Moreover, A(beta) (1-40) significantly decreased the basal activity of the PIP2-PLC in SPM and the enzyme activity regulated through cholinergic receptors