context: The aim of this study was to determine the level of sICAM-1 in sera of @entity1378 and euthyroid @entity1 with @entity2743 and find correlation between thyroid function, anti-TSH receptor as well as anti-thyroid antibodies. Comparative determination of sICAM-1, TSH and thyroid hormones, anti-TSH receptor- as well as anti-thyroglobin-, anti-thyroid peroxidase antibodies was made in sera of Graves' @entity1 . Thirty @entity1 with untreated @entity2743 (12 had @entity6875 ) were studied before and after @entity3937 treatment. sICAM-1 was measured by ELISA using monoclonal antibodies to @entity1 @entity2071 . The sICAM-1 was significantly elevated in @entity2743 ' @entity1 (738.9 +/- 151 ng/ml) compared to controls (212 +/- 42 ng/ml) (p < 0.0001). Both in @entity1378 and euthyroid Graves' groups with @entity6875 the sICAM-1 proved to be higher than those without @entity6875 . Correlations were observed between sICAM-1 and serum @entity1955 , @entity1954 and anti-TSH receptor antibodies (r = 0.91, 0.83 and 0.61, respectively). There was, however, no association of serum @entity2071 levels with anti-thyroid peroxidase or anti-thyroglobulin antibodies. It was concluded that elevation of sICAM-1 can be the consequence of @entity1378 and the autoimmune processes mediated by anti-TSH receptor antibodies as well as cytokines. The elevated level of sICAM-1 might be important both in regulation of autoimmune mechanism and "homing" phenomenon of lymphocytes in @entity2743 .
  