context: Bacterial specificity in @entity1 periodontal diseases suggests the possibility of diagnosing and treating @entity2521 as @entity281 and using microbiological diagnostic means to evaluate the efficacy of periodontal therapy. In a series of clinical trials, the usefulness of topical antimicrobial agents in combination with surgical and non-surgical conventional periodontal therapy were tested. The healing result was estimated by monitoring probing attachment levels (PAL). The usefulness of clinical and microbiological parameters to evaluate post-treatment healing result was tested. 9 of the @entity1 exhibiting sites with recurrent @entity2520 were then evaluated for clinical and microbiological parameters to define accurate means to differentiate between active and @entity2520 . The results showed that the frequency of periodontal lesions with significant @entity6730 after treatment was less in @entity1 treated with antimicrobial agent. Specific microbiological parameters showed stronger correlation than clinical parameters with gain and/or @entity6730 post-treatment. Thus @entity3841 and @entity2523 occurred in periodontal lesions with progressing disease after treatment, but were rarely detected in samples from pockets of the same depths which did not exhibit further @entity6730 over a study period of 1 year. This study points to the usefulness of topical antimicrobial agent as an adjunct to mechanical subgingival debridement in the treatment of @entity2521 in adults. The results also indicate the utility of diagnostic microbiology in the assessment of @entity2520 activity post-treatment.
  