text: However, both compounds have similar molecular mechanisms of neuroprotection in neuronal cell cultures and animal neurodegenerative models, indicating that the neuroprotective effect of rasagiline does not depend on inhibition of MAO-B, but rather is associated with the << N-propargyl >> moiety, which promotes mitochondrial viability and stabilizes permeability transition by regulating [[ Bcl-2 ]] family proteins.