text: We report here that a human degradation-resistant GLP-2 analogue, h[Gly2]-GLP-2 significantly improves survival, reduces bacteremia, attenuates epithelial injury, and inhibits crypt apoptosis in the murine gastrointestinal tract after administration of << topoisomerase I >> inhibitor [[ irinotecan hydrochloride ]] or the antimetabolite 5-fluorouracil.