text: We have previously demonstrated that phosphorylation of Fas-associated death domain-containing protein (FADD) at 194 serine through << c-jun NH2-terminal kinase >> (JNK) activation sensitizes breast cancer cells to chemotherapy through accelerating cell cycle arrest at G2/M, and that Bcl-2 phosphorylation downstream of JNK/FADD plays an important role in cell growth suppression by [[ paclitaxel ]].