text: Glutathione-independent prostaglandin D synthase [prostaglandin-H2 D-isomerase; << (5Z,13E)-(15S)-9 alpha,11 alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase >>, EC 5.3.99.2] is an enzyme responsible for biosynthesis of [[ prostaglandin D2 ]] in the central nervous system.