text: Estimated affinities for the fast-inactivated channel state were 81 nM, 312 nM and 227 nM for 4-iodopropofol, << 4-bromopropofol >> and 4-chloropropofol in [[ Na(V)1.4 ]], and 450 nM for 4-chloropropofol in Na(V)1.2.