text: Another inhibitor, << brequinar >> was previously reported to be a slow-binding inhibitor of the [[ human dihydroorotate dehydrogenase ]] [W. Knecht, M. Loffler, Species-related inhibition of human and rat dihyroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives, Biochem. Pharmacol. 56 (1998) 1259-1264].