text: Another inhibitor, brequinar was previously reported to be a slow-binding inhibitor of the human dihydroorotate dehydrogenase [W. Knecht, M. Loffler, Species-related inhibition of << human and rat dihyroorotate dehydrogenase >> by immunosuppressive isoxazol and [[ cinchoninic acid ]] derivatives, Biochem. Pharmacol. 56 (1998) 1259-1264].