The potentiation of heteromeric << KARs >> by mGlu1 activation was attenuated by GDPβS, blocked by an inhibitor of phospholipase C or the calcium chelator [[ 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid ]] (BAPTA), prolonged by the phosphatase inhibitor okadaic acid, but unaffected by the tyrosine kinase inhibitor lavendustin A.