To mimic chronic selective serotonin reuptake inhibitor treatment and to block the inhibitory 5-HT(1A) autoreceptors, a << 5-HT(1A) >> antagonist, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclo hexanecarboxamide maleate salt ([[ WAY-100635 ]]) (0.3 mg/kg s.c.), was administered with DVS (30 mg/kg orally).