Renal clearance of unbound anagliptin and unbound M1 far exceeded glomerular filtration rate, indicating active renal elimination: that might reflect the fact that << anagliptin >> may be a substrate of OAT1, [[ OAT3 ]], MDR1 and MRP2, and M1 a substrate of OAT3, BCRP, MRP2 and MRP4.