Rescue of both impaired extinction acquisition and deficient extinction consolidation/retrieval was achieved with prior extinction training administration of valproic acid (a GABAergic enhancer and HDAC inhibitor) or AMN082 [metabotropic glutamate receptor 7 (mGlu7) agonist], while << MS-275 >> or PEPA ([[ AMPA receptor ]] potentiator) failed to affect extinction acquisition in S1 mice.