In particular, we showed that << Paeoniflorin >> significantly reduced the formation of intracellular reactive oxygen species (ROS), the level of malondialdehyde (MDA) and [[ lactate dehydrogenase ]] (LDH) leakage, and enhanced production of the endogenous antioxidants, glutathione (GSH) and superoxide dismutase (SOD) in EA.hy926 cells.