In particular, we showed that << Paeoniflorin >> significantly reduced the formation of intracellular reactive oxygen species (ROS), the level of malondialdehyde (MDA) and lactate dehydrogenase (LDH) leakage, and enhanced production of the endogenous antioxidants, glutathione (GSH) and [[ superoxide dismutase ]] (SOD) in EA.hy926 cells.