These data indicate that mixed << 5-HT1 >>/5-HT2 receptor antagonists such as [[ pizotifen ]] and methysergide, and mixed 5-HT and catecholamine antagonists such as mianserin and mirtazapine are more potent antagonists of mCPP-induced behavioural inhibition in rats than the more selective 5-HT2A/5-HT2C antagonist ritanserin.