text: In a further study to analyse the downstream mediator of Rac in the ceramide-signalling pathway, we observed that either pretreatment with mepacrine, a potent and specific inhibitor of phospholipase A2, or co-transfection with antisense cytosolic phospholipase A2 (cPLA2) oligonucleotide repressed the << C2-ceramide >>-induced [[ SRE ]] activation selectively, implying a critical role of cPLA2 in C2-ceramide-induced signalling to nucleus.