text: Based on these suggestions, the rational redesign of furanopyrimidine 24 (clog P=7.41; Aurora A IC(50) =43 nM; HCT-116 IC(50) =400 nM) led to the identification of << quinazoline >> 67 (clog P=5.28; [[ Aurora A ]] IC(50) =25 nM; HCT-116 IC(50) =23 nM).