text: To confirm this novel mechanism of bleomycin-induced fibrogenesis, we attempted to upregulate Nrf2 and related antioxidant proteins in bleomycin-treated fibroblasts using a putative << Nrf2 >> activator, [[ caffeic acid phenethyl ester ]], and the results showed that bleomycin-induced fibroblast proliferation and collagen content were attenuated through improved redox balance.