text: Given these findings, a unified PK model including the inhibition of MAO-A- and CYP2D6-catalyzed << 5-MeO-DMT >> metabolism by harmaline was developed to describe blood harmaline, 5-MeO-DMT, and bufotenine PK profiles in both wild-type and Tg-[[ CYP2D6 ]] mouse models.