text: << S1P >> activated phosphatidylinositol 3-kinase (PI3K)/[[ Akt ]] signaling, leading to the inhibition of glycogen synthase kinase-3β and the nuclear translocation of β-catenin, followed by the increase of the transcriptional activity by β-catenin/T-cell factor complex formation in both SaOS-2 cells and MC3T3-E1 cells.