text: Given these findings, a unified PK model including the inhibition of MAO-A- and << CYP2D6 >>-catalyzed [[ 5-MeO-DMT ]] metabolism by harmaline was developed to describe blood harmaline, 5-MeO-DMT, and bufotenine PK profiles in both wild-type and Tg-CYP2D6 mouse models.