text: A structure-activity relationship (SAR) study of the c-Myc (<< Myc >>) inhibitor 10074-G5 ([[ N-([1,1'-biphenyl]-2-yl)-7-nitrobenzo[c][1,2,5]oxadiazol-4-amine ]], 1) - which targets a hydrophobic domain of the Myc oncoprotein that is flanked by arginine residues - was executed in order to determine its pharmacophore.