text: Given these findings, a unified PK model including the inhibition of MAO-A- and << CYP2D6 >>-catalyzed 5-MeO-DMT metabolism by harmaline was developed to describe blood harmaline, [[ 5-MeO-DMT ]], and bufotenine PK profiles in both wild-type and Tg-CYP2D6 mouse models.