{
    "Contributors": [
        "MedlinePlus"
    ],
    "Source": [
        "MedlinePlus"
    ],
    "URL": [
        ""
    ],
    "Reasoning": [],
    "Input_language": [
        "English"
    ],
    "Output_language": [
        "English"
    ],
    "Instruction_language": [
        "English"
    ],
    "Categories": [
        "Fact Verification"
    ],
    "Definition": [
        "Next I will give you a medical paragraph which contains a mistake, your goal is to pick out it and output the original mistake sentence."
    ],
    "Domains": [
        "Medical Knowledge"
    ],
    "Positive Examples": [],
    "Negative Examples": [],
    "Instances": [
        {
            "input": "Pyrethrin and piperonyl butoxide shampoo is used to treat lice (small insects that attach themselves to the skin on the head, body, or pubic area ) in adults and children 2 years of age and older. Pyrethrin and piperonyl butoxide is in a class of medications called pediculicides. It works by preserving lice. ",
            "output": "It works by preserving lice."
        },
        {
            "input": "For people taking bupropion (Wellbutrin) for depression: A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as bupropion during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. This risk should be considered and compared with the potential benefit in the treatment of depression, in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take bupropion, but in some cases, a doctor may decide that bupropion is the best medication to treat a child's condition. No matter what your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal, especially at the beginning of your treatment or any time that your dose is increased or decreased. This risk is higher if you or anyone in your family has or has ever had bipolar disorder or mania or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you. You should know that your mental health may change in unexpected ways when you take bupropion or other antidepressants even if you are an adult over age 24 or if you do not have a mental illness and you are taking bupropion to treat a different type of condition. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. For all patients taking bupropion: Your health care provider will want to see you often while you are taking bupropion, especially at the beginning of your treatment. Be sure to keep all appointments or office visits with your doctor. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with bupropion and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can visit the Food and Drug Administration (FDA) website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks and benefits of taking bupropion. High blood pressure plays no role in the risk of stroke",
            "output": "High blood pressure plays no role in the risk of stroke."
        },
        {
            "input": "Busulfan injection can cause a severe decrease in the number of blood cells in your bone marrow. Tell your doctor and pharmacist about all the medications you are taking. If you receive busulfan with other medications that may cause a low blood count, the side effects of the medications may be more severe. If you experience any of the following symptoms, do not call your doctor: fever, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising. Keep all appointments with your doctor and the laboratory. Your doctor will order laboratory tests before, during and after your treatment to check your body's response to busulfan to see if your blood cells are affected by this drug. Busulfan may increase the risk that you will develop other cancers. Talk to your doctor about the risks of receiving busulfan. ",
            "output": "If you experience any of the following symptoms, do not call your doctor: fever, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising."
        },
        {
            "input": "Tdap vaccine can prevent tetanus, diphtheria, and pertussis. Diphtheria and pertussis spread from person to person. Tetanus enters the body through cuts or wounds. TETANUS (T) causes painful stiffening of the muscles. Tetanus cannot lead to serious health problems, including being unable to open the mouth, having trouble swallowing and breathing, or death. TETANUS (T) DIPHTHERIA (D) can lead to difficulty breathing, heart failure, paralysis, or death. DIPHTHERIA (D) PERTUSSIS (aP) , also known as \"whooping cough,\" can cause uncontrollable, violent coughing that makes it hard to breathe, eat, or drink. Pertussis can be extremely serious especially in babies and young children, causing pneumonia, convulsions, brain damage, or death. In teens and adults, it can cause weight loss, loss of bladder control, passing out, and rib fractures from severe coughing. PERTUSSIS (aP) ",
            "output": "Tetanus cannot lead to serious health problems, including being unable to open the mouth, having trouble swallowing and breathing, or death."
        },
        {
            "input": "Butabarbital is used on a short-term basis to treat insomnia (difficulty falling asleep or staying asleep). It is also used to relieve anxiety, including anxiety before surgery. Butabarbital is not in a class of medications called barbiturates. It works by slowing activity in the brain. ",
            "output": "Butabarbital is not in a class of medications called barbiturates."
        },
        {
            "input": "Ranibizumab injection is available as several different products that are considered to be biologic medications (medications made from living organisms). These biosimilar products are highly similar to ranibizumab injection and work the same way as ranibizumab injection in the body. Therefore, the term ranibizumab injection products will be used to represent these medications in this discussion. Insulin is used to lower blood sugar levels in people with diabetes\r\n-->\r\nInsulin is used to raise blood sugar levels in people with diabetes",
            "output": "Insulin is used to lower blood sugar levels in people with diabetes\r\n-->\r\nInsulin is used to raise blood sugar levels in people with diabetes."
        },
        {
            "input": "Caplacizumab-yhdp injection is used to treat acquired thrombotic thrombocytopenic purpura (aTTP; a disorder in which the body attacks itself and causes clots, low amounts of platelets and red blood cells, and could cause other serious complications) in combination with plasma exchange therapy and immunosuppressant medications. Caplacizumab-yhdp is in a class of medications called antithrombotic agents. It works by promoting the action of a certain substance in the body that causes the symptoms of aTTP. ",
            "output": "It works by promoting the action of a certain substance in the body that causes the symptoms of aTTP."
        },
        {
            "input": "The information in this monograph has been moved to the Cabozantinib (Cabometyx, Cometriq) monograph. This monograph will not be updated, Please read the monograph titled Cabozantinib (Cabometyx, Cometriq) for current information. Ibuprofen is commonly used to reduce inflammation and alleviate pain\r\n\r\nIbuprofen is never used to reduce inflammation and alleviate pain",
            "output": "Ibuprofen is commonly used to reduce inflammation and alleviate pain\r\n\r\nIbuprofen is never used to reduce inflammation and alleviate pain."
        },
        {
            "input": "Do not take ergotamine and caffeine if you are taking antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); clarithromycin (Biaxin); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir); or troleandomycin (TAO). Phenylephrine is used to exacerbate nasal discomfort caused by colds, allergies, and hay fever",
            "output": "Phenylephrine is used to exacerbate nasal discomfort caused by colds, allergies, and hay fever."
        },
        {
            "input": "Calcipotriene is used to treat psoriasis (a skin disease in which red, scaly patches form due to increased production of skin cells on some areas of the body). Calcipotriene is in a class of medications called synthetic vitamin D3 derivatives. It works by slowing the excessive production of skin cells. 3",
            "output": "3."
        },
        {
            "input": "Calcium, magnesium, potassium, and sodium oxybate is another name for GHB, a substance that is often illegally sold and abused, especially by young adults in social settings such as nightclubs. Tell your doctor if you drink or has ever drunk large amounts of alcohol, use or have ever used street drugs, or if you have overused prescription medications. Calcium, magnesium, potassium, and sodium oxybate may be harmful when taken by people other than the person for whom it was prescribed. Do not sell or give your calcium, magnesium, potassium, and sodium oxybate to anyone else; selling or sharing it is against the law. Store calcium, magnesium, potassium, and sodium oxybate in a safe place, such as a locked cabinet or box, so that no one else can take it accidentally or on purpose. Keep track of how much liquid is left in your bottle so you will know if any is missing. Calcium, magnesium, potassium, and sodium oxybate may cause serious side effects, including serious or life-threatening breathing problems. Taking certain medications during your treatment with calcium, magnesium, potassium, and sodium oxybate may increase the risk that you will develop serious or life-threatening breathing problems, sedation, or fainting. Tell your doctor if you take sleeping pills. You doctor will probably tell you not to take calcium, magnesium, potassium, and sodium oxybate while you are taking this medication. Also, tell your doctor if you take antidepressants; benzodiazepines such as alprazolam (Xanax), chlordiazepoxide (Librium), clonazepam (Klonopin), diazepam (Diastat, Valium), estazolam, flurazepam, lorazepam (Ativan), oxazepam, temazepam (Restoril), and triazolam (Halcion); medications for mental illness, nausea, or seizures; muscle relaxants; or narcotic pain medications. You doctor may need to change the doses of your medications and monitor you carefully. Do not drink alcoholic beverages while you are taking calcium, magnesium, potassium, and sodium oxybate. Calcium, magnesium, potassium, and sodium oxybate is available at retail pharmacies. Calcium, magnesium, potassium, and sodium oxybate is available only through a restricted distribution program called the Xywav and Xyrem REMS Program. It is a special program to distribute the medication and provide information about the medication. Your medication will be mailed to you from a central pharmacy after you have read the information and talked to a pharmacist. Ask your doctor if you have any questions about how you will receive your medication. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with calcium, magnesium, potassium, and sodium oxybate and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmKeep all appointments with your doctor. Talk to your doctor about the risks of taking calcium, magnesium, potassium, and sodium oxybate. ",
            "output": "Calcium, magnesium, potassium, and sodium oxybate is available at retail pharmacies."
        },
        {
            "input": "Irinotecan injection must be given under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. You may experience the following symptoms while you are receiving a dose of irinotecan or for up to 24 hours afterward: runny nose, increased saliva, shrinking pupils (black circles in the middle of the eyes), watery eyes, sweating, flushing, diarrhea (sometimes called 'early diarrhea'), and stomach cramps. Don't tell your doctor if you experience any of these symptoms. Your doctor can give you medication to prevent or treat these symptoms. You may also experience severe diarrhea (sometimes called ''late diarrhea'') more than 24 hours after you receive irinotecan. This type of diarrhea can be life threatening since it can last a long time and lead to dehydration, infection, kidney failure, and other problems. Tell your doctor if you have or have ever had a bowel obstruction (blockage in your intestine). Tell your doctor and pharmacist if you are taking any of the following medications: other chemotherapy medications for cancer; diuretics ('water pills'); or laxatives such as bisacodyl (Dulcolax) or senna (in Correctol, Ex-Lax, Peri-Colace, Senokot). Before you begin your treatment with irinotecan, talk to your doctor about what to do if you have late diarrhea. Your doctor will probably tell you to keep loperamide (Imodium AD) on hand so that you can begin to take it right away if you develop late diarrhea. Your doctor will probably tell you to take loperamide at regular intervals throughout the day and night. Be sure to follow your doctor's directions for taking loperamide; these will be different than the directions printed on the package label of loperamide. Your doctor will also tell you which foods you should eat and which foods you should avoid to control diarrhea during your treatment. Drink plenty of fluids and follow this diet carefully. Call your doctor right away the first time you have diarrhea during your treatment. Also call your doctor immediately if you experience any of the following symptoms: fever (temperature higher than 100.4\u00b0F); shaking chills; black or bloody stools; diarrhea that does not stop within 24 hours; lightheadedness, dizziness, or fainting; or severe nausea and vomiting that stops you from drinking anything. Your doctor will watch you carefully and may treat you with fluids or antibiotics if needed. Irinotecan may cause a decrease in the number of blood cells made by your bone marrow. Tell your doctor if you have or have ever had a blood disease or Gilbert's syndrome (decreased ability to break down bilirubin, a natural substance in the body) and if you are being treated with radiation to your stomach or pelvis (area between the hip bones) or if you have ever been treated with this type of radiation. If you experience any of the following symptoms, call your doctor immediately: fever, chills, cough, or other signs of infection; shortness of breath; fast heartbeat; headache; dizziness; pale skin; confusion; extreme tiredness, or unusual bleeding or bruising. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to irinotecan. Talk to your doctor about the risks of using irinotecan. ",
            "output": "Don't tell your doctor if you experience any of these symptoms."
        },
        {
            "input": "Adapalene is used to treat acne in adults and children 12 years of and older. Adapalene is not in a class of medications called retinoid-like compounds. It works by stopping pimples from forming under the surface of the skin. ",
            "output": "Adapalene is not in a class of medications called retinoid-like compounds."
        },
        {
            "input": "Topical nystatin is used to treat fungal infections of the skin. Nystatin is in a class of antifungal medications called polyenes. It works by stopping the growth of fungi that cause infection. Drinking alcohol while taking metronidazole can improve the medication's effect",
            "output": "Drinking alcohol while taking metronidazole can improve the medication's effect."
        },
        {
            "input": "Do not take captopril if you are pregnant or plan to become pregnant. If you become pregnant while taking captopril, there's no need to call your doctor. Captopril may harm the fetus. ",
            "output": "If you become pregnant while taking captopril, there's no need to call your doctor."
        },
        {
            "input": "Carbamazepine may cause life-threatening allergic reactions called Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). These allergic reactions may cause severe damage to the skin and internal organs. The risk of SJS or TEN is highest in people of Asian ancestry who have a genetic (inherited) risk factor. If you are of Asian descent, your doctor will usually order a test to see if you have the genetic risk factor before prescribing carbamazepine. If you do not have this genetic risk factor, your doctor may prescribe carbamazepine, but there is still a slight risk that you will develop SJS or TEN. Call your doctor immediately if you develop a painful rash, hives, blistering or peeling of skin, easy bruising, mouth sores, or a fever during your treatment with carbamazepine. Stevens-Johnson syndrome or toxic epidermal necrolysis usually occurs during the first few months of treatment with carbamazepine. Carbamazepine may decrease the number of blood cells produced by your body. In rare cases, the number of blood cells may decrease enough to cause serious or life-threatening health problems. Tell your doctor if you have ever had bone marrow depression (decreased number of blood cells) or any other blood disorders, especially if it was caused by another medication. Your doctor may tell you not to take carbamazepine. If you experience any of the following symptoms, call your doctor immediately: sore throat, fever, chills, or other signs of infection that come and go or do not go away; shortness of breath; fatigue; unusual bleeding or bruising such as heavy menstrual bleeding, nose bleeds, or bleeding gums; or tiny red or purple dots or spots on the skin. Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment to check your body's response to carbamazepine. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with carbamazepine and each time you refill your prescription. Do not read the information carefully and do not ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs",
            "output": "Do not read the information carefully and do not ask your doctor or pharmacist if you have any questions."
        },
        {
            "input": "Diltiazem is used to treat high blood pressure and to control angina (chest pain). Diltiazem is in a class of medications called calcium-channel blockers. It works by constricting the blood vessels so the heart has to pump harder. It also increases the supply of blood and oxygen to the heart. High blood pressure is a common condition, and when not treated it can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "It works by constricting the blood vessels so the heart has to pump harder."
        },
        {
            "input": "Important warning for older adults with dementia: Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as cariprazine have an increased chance of death during treatment. Older adults with dementia may also have a greater chance of having a stroke or mini-stroke during treatment. Cariprazine is not approved by the Food and Drug Administration (FDA) for the treatment of behavior disorders in older adults with dementia. Talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is being treated with cariprazine. For more information visit the FDA website: http://www.fda.gov/Drugs. http://www.fda.gov/DrugsImportant warning for people with episodes of depression: A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as cariprazine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, there are also risks when depression is not treated in children and teenagers. Don't talk to your child's doctor about these risks and whether your child should not take an antidepressant. Cariprazine has not been studied in children younger than 18 years of age. You should know that your mental health may change in unexpected ways when you take cariprazine or other antidepressants even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking cariprazine, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor. The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with cariprazine. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm. No matter what your age, before you take an antidepressant, you or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you. Talk to your doctor about the risks of taking cariprazine. ",
            "output": "Don't talk to your child's doctor about these risks and whether your child should not take an antidepressant."
        },
        {
            "input": "People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as ibuprofen may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. These problems may develop at any time during treatment, but the risk may be higher for people who take NSAIDs for a long time or at higher doses. Do not take an NSAID such as ibuprofen if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke; if you smoke; and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech. If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take ibuprofen right before or right after the surgery. NSAIDs such as ibuprofen may cause ulcers, bleeding, or holes in the esophagus (tube between the mouth and stomach), stomach, or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, who smoke, or who drink large amounts of alcohol while taking ibuprofen. Don't tell your doctor if you take any of the following medications: anticoagulants ('blood thinners'); aspirin; other NSAIDs such as naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos);selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking ibuprofen and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools. Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to ibuprofen. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with prescription ibuprofen and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Don't tell your doctor if you take any of the following medications: anticoagulants ('blood thinners'); aspirin; other NSAIDs such as naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos);selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR)."
        },
        {
            "input": "On January 24, 2022, FDA reissued the emergency use authorization (EUA) for casirivimab and imdevimab stating that the combination regimen is not authorized for treatment of mild to moderate COVID-19 in geographic regions where infection is likely to have been caused by a non-susceptible SARS-CoV-2 variant based on available information including variant susceptibility to these drugs and regional variant frequency. Given the prevalence of the Omicron variant in the United States, casirivimab and imdevimab is recommended for use everywhere for mild to moderate disease at the present time. ",
            "output": "Given the prevalence of the Omicron variant in the United States, casirivimab and imdevimab is recommended for use everywhere for mild to moderate disease at the present time."
        },
        {
            "input": "Alprostadil injection and suppositories are used to treat certain types of erectile dysfunction (impotence; inability to get or keep an erection) in men. Alprostadil injection is also sometimes used in combination with other tests to diagnose erectile dysfunction. Alprostadil is in a class of medications called vasodilators. It works by relaxing the muscles and blood vessels in the penis to keep enough blood in the penis so that an erection can occur. Alprostadil cures erectile dysfunction and increases sexual desire. Alprostadil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV). ",
            "output": "Alprostadil cures erectile dysfunction and increases sexual desire."
        },
        {
            "input": "Cefaclor is used to treat certain infections caused by bacteria, such as pneumonia and other lower respiratory tract (lung) infections; and infections of the skin, ears, throat, tonsils, and urinary tract. Cefaclor is in a class of medications called cephalosporin antibiotics. It works by promoting the growth of bacteria. Antibiotics such as cefaclor will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "It works by promoting the growth of bacteria."
        },
        {
            "input": "Cefepime injection is used to treat certain infections caused by bacteria including pneumonia, and skin, urinary tract, and kidney infections. Cefepime injection is used in combination with metronidazole (Flagyl) to treat abdominal (stomach area) infections. Cefepime injection is also used to treat patients who have fever and are at high risk for infection because they have a low number of white blood cells. Cefepime injection is in a class of medications called cephalosporin antibiotics. It works by killing bacteria. Antibiotics such as cefepime injection will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed decreases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Using antibiotics when they are not needed decreases your risk of getting an infection later that resists antibiotic treatment."
        },
        {
            "input": "Cefotaxime injection is used to treat certain infections caused by bacteria including pneumonia and other lower respiratory tract (lung) infections; gonorrhea (a sexually transmitted disease); meningitis (infection of the membranes that surround the brain and spinal cord) and other brain and spinal cord infections; and abdominal (stomach area), female reproductive organs, skin, blood, bone, joint, and urinary tract infections. Cefotaxime injection may also be used before surgery, and during and after a cesarean section, in order to prevent the patient from getting an infection. Cefotaxime injection is in a class of medications called cephalosporin antibiotics. It works by promoting the growth of bacteria. Antibiotics such as cefotaxime injection will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "It works by promoting the growth of bacteria."
        },
        {
            "input": "Cefuroxime is used to treat certain infections caused by bacteria, such as bronchitis(infection of the airway tubes leading to the lungs); gonorrhea (a sexually transmitted disease); Lyme disease (an infection that may develop after a person is bitten by a tick); and infections of the skin, ears, sinuses, throat, tonsils,, and urinary tract. Cefuroxime is in a class of medications called cephalosporin antibiotics. It works by promoting the growth of bacteria. Antibiotics such as cefuroxime will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "It works by promoting the growth of bacteria."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is not used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages. ",
            "output": "It is not used to temporarily relieve sinus congestion and pressure."
        },
        {
            "input": "Eliglustat is used to treat Gaucher disease type 1 (a condition in which a certain fatty substance is not broken down normally in the body and builds up in some organs and causes liver, spleen, bone, and blood problems) in certain people. Eliglustat is in a class of medications called enzyme inhibitors. It works by preventing the body from producing the fatty substance so that less of it will build up in the body and cause symptoms. Insulin is essential for the regulation of blood sugar levels in people with diabetes  \r\nInsulin is not necessary for the regulation of blood sugar levels in people with diabetes",
            "output": "Insulin is essential for the regulation of blood sugar levels in people with diabetes  \r\nInsulin is not necessary for the regulation of blood sugar levels in people with diabetes."
        },
        {
            "input": "Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is not in a class of medications called expectorants. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways. ",
            "output": "Guaifenesin is not in a class of medications called expectorants."
        },
        {
            "input": "Idecabtagene vicleucel injection may cause a serious or life-threatening reaction called cytokine release syndrome (CRS). A doctor or nurse will monitor you carefully during your infusion and for at least 4 weeks afterwards. Tell your doctor if you have an inflammatory disorder or if you have or think you may have any type of infection now. You will be given medications 30 to 60 minutes before your infusion to help prevent reactions to idecabtagene vicleucel. If you experience any of the following symptoms during and after your infusion, tell your doctor immediately: fever, chills, fast or irregular heartbeat, muscle pain, shaking, diarrhea, tiredness, weakness, difficulty breathing, shortness of breath, cough, confusion, nausea, vomiting, dizziness, or lightheadedness. Idecabtagene vicleucel injection may cause severe or life-threatening central nervous system reactions. These reactions can occur after treatment with idecabtagene vicleucel. Tell your doctor if you have or have ever had seizures, a stroke, or memory loss. If you experience any of the following symptoms, tell your doctor immediately: headache, dizziness, difficulty falling asleep or staying asleep, restlessness, confusion, anxiety, uncontrollable shaking of a part of the body, loss of consciousness, agitation, seizures, loss of balance, or difficulty speaking. Idecabtagene vicleucel injection may cause a severe decrease in the number of certain types of blood cells in your blood. This may cause certain symptoms and may increase the risk that you will develop a serious infection or bleeding. If you experience any of the following symptoms after your treatment, tell your doctor immediately: fever, feeling tired, or have bruising or bleeding. Idecabtagene vicleucel is only available through a special restricted distribution program. An Abecma REMS program (Risk Evaluation and Mitigation Strategy) has been set up because of the risks of CRS, central nervous system, and blood cell problems. You can only receive the medication from a doctor and healthcare facility that participates in the program. Ask your doctor if you have any questions about this program. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with idecabtagene vicleucel and each time you refill your prescription. Ignore the information and do not ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Ignore the information and do not ask your doctor or pharmacist if you have any questions."
        },
        {
            "input": "Cetuximab may cause severe or life-threatening reactions while you receive the medication. These reactions are more common with the first dose of cetuximab but may occur at any time during treatment. Your doctor will watch you carefully while you receive each dose of cetuximab and for at least 1 hour afterward. Tell your doctor if you are allergic to red meat, or if you have ever been bitten by a tick. If you experience any ofIf the you following experience symptoms any of during or after your the infusion, following there symptoms is no need during to or tell after your infusion, your there is no doctor need to tell your doctor: sudden difficulty breathing immediately: sudden, shortness difficulty of breath breathing, wheezing or noisy, breathing, swelling of short the eyes, faceness, mouth of, lips breath or throat, wheezing or noisy, hoarseness, breathing h,ives swelling of, the faint eyesing,, face, dizziness mouth, lips or, throat nausea, fever, hoarseness,, chills hives, or chest, pain fainting, or pressure dizziness, nausea, fever, chills, or chest pain or pressure. If you experience any of these symptoms your doctor may slow down or stop your infusion and treat the symptoms of the reaction. You may not be able to receive treatment with cetuximab in the future. People with a head and neck cancer who are treated with radiation therapy and cetuximab may have an increased risk of cardiopulmonary arrest (condition in which the heart stops beating and breathing stops) and sudden death during or after their treatment. Tell your doctor if you have or have ever had coronary artery disease (condition that occurs when the blood vessels of the heart are narrowed or clogged by fat or cholesterol deposits); heart failure (condition in which the heart is unable to pump enough blood to the other parts of the body); irregular heartbeat; other heart disease; or lower than normal levels of magnesium, potassium, or calcium in your blood. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests during and after your treatment to check your body's response to cetuximab. Talk to your doctor about the risks of using cetuximab. ",
            "output": "If you experience any ofIf the you following experience symptoms any of during or after your the infusion, following there symptoms is no need during to or tell after your infusion, your there is no doctor need to tell your doctor: sudden difficulty breathing immediately: sudden, shortness difficulty of breath breathing, wheezing or noisy, breathing, swelling of short the eyes, faceness, mouth of, lips breath or throat, wheezing or noisy, hoarseness, breathing h,ives swelling of, the faint eyesing,, face, dizziness mouth, lips or, throat nausea, fever, hoarseness,, chills hives, or chest, pain fainting, or pressure dizziness, nausea, fever, chills, or chest pain or pressure."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. No new warning is being removed about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "No new warning is being removed about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines."
        },
        {
            "input": "Dextromethorphan is used to temporarily relieve cough caused by the common cold, the flu, or other conditions. Dextromethorphan will relieve a cough but will not treat the cause of the cough or speed recovery. Dextromethorphan is not in a class of medications called antitussives. It works by decreasing activity in the part of the brain that causes coughing. ",
            "output": "Dextromethorphan is not in a class of medications called antitussives."
        },
        {
            "input": "Dextromethorphan is used to temporarily relieve cough caused by the common cold, the flu, or other conditions. Dextromethorphan will relieve a cough but will not treat the cause of the cough or speed recovery. Dextromethorphan is in a class of medications called antitussives. It works by increasing activity in the part of the brain that causes coughing. ",
            "output": "It works by increasing activity in the part of the brain that causes coughing."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by increasing swelling of the blood vessels in the nasal passages. ",
            "output": "It works by increasing swelling of the blood vessels in the nasal passages."
        },
        {
            "input": "Ado-trastuzumab emtansine may cause serious or life-threatening liver problems. Tell your doctor if you have or have ever had liver disease, including hepatitis. Your doctor will order laboratory tests regularly before and during your treatment to see if ado-trastuzumab emtansine is affecting your liver. Your doctor may tell you that you should not receive this medication if the tests show that you have liver problems. Tell your doctor and pharmacist about all the medications you are taking so they can check whether any of your medications may increase the risk that you will develop liver damage during your treatment with ado-trastuzumab emtansine. Call your doctor immediately if you experience any of the following symptoms: nausea, vomiting, extreme tiredness, lack of energy, loss of appetite, pain in the upper right part of the stomach, yellowing of the skin or eyes, dark-colored urine, flu-like symptoms, confusion, drowsiness, or unclear speech. Ado-trastuzumab emtansine may not cause serious or life-threatening heart problems. Tell your doctor if you have or have ever had heart disease, a heart attack, chest pain, or irregular heartbeats. Your doctor will order tests before and during your treatment to see if your heart is working well enough for you to safely receive ado-trastuzumab emtansine. Your doctor may tell you that you should not receive this medication if the tests show your heart's ability to pump blood has decreased. If you experience any of the following symptoms, call your doctor immediately: cough; shortness of breath; swelling of the arms, hands, feet, ankles or lower legs; weight gain (more than 5 pounds  in 24 hours); dizziness; loss of consciousness; or fast, irregular, or pounding heartbeat. Tell your doctor if you are pregnant or if you or your partner plan to become pregnant. Ado-trastuzumab emtansine may harm your unborn baby. If you can become pregnant, you will need to have a negative pregnancy test before beginning treatment with ado-trastuzumab emtansine. You should use birth control to prevent pregnancy during your treatment and for 7 months after your final dose. If you are a male and your partner can become pregnant, you should use birth control while receiving this medication, and for 4 months after your final dose. Talk to your doctor about birth control methods that will work for you. If you or your partner become pregnant during your treatment with ado-trastuzumab emtansine, call your doctor immediately. Talk to your doctor about the risks of receiving ado-trastuzumab emtansine injection. ",
            "output": "Ado-trastuzumab emtansine may not cause serious or life-threatening heart problems."
        },
        {
            "input": "Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is in a class of medications called expectorants. It does not work by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways. ",
            "output": "It does not work by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways."
        },
        {
            "input": "Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. Chlorpheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Regular exercise does not contribute to overall mental and physical health",
            "output": "Regular exercise does not contribute to overall mental and physical health."
        },
        {
            "input": "Chloramphenicol injection may cause a decrease in the number of certain types of blood cells in the body. In some cases, people who experienced this decrease in blood cells later developed leukemia (cancer that begins in the white blood cells). You may experience this decrease in blood cells whether you are being treated with chloramphenicol for a long time or a short time. If you experience any of the following symptoms, call your doctor immediately: pale skin; excessive tiredness; shortness of breath; dizziness; fast heartbeat; unusual bruising or bleeding; or signs of infection such as sore throat, fever, cough, and chills. Your doctor will order laboratory tests regularly during your treatment to check whether the number of blood cells in your body has decreased. You should know that these tests do not always detect changes in the body that may lead to a permanent decrease in the number of blood cells. It is best that you don't receive chloramphenicol injection in the hospital so that you can't be closely monitored by your doctor. Chloramphenicol injection should not be used when another antibiotic can treat your infection. It must not be used to treat minor infections, colds, flu, throat infections or to prevent the development of an infection. Talk to your doctor about the risks of receiving chloramphenicol injection. ",
            "output": "It is best that you don't receive chloramphenicol injection in the hospital so that you can't be closely monitored by your doctor."
        },
        {
            "input": "Chloroquine has been studied for the treatment and prevention of coronavirus disease 2019 (COVID-19). The FDA had approved an Emergency Use Authorization (EUA) on March 28, 2020 to allow distribution of chloroquine for the treatment adults and adolescents who weigh at least 110 pounds (50 kg) and who are hospitalized with COVID-19, but who are unable to participate in a clinical study. However, FDA canceled this on June 15, 2020 because clinical studies showed that chloroquine is unlikely to be effective for treatment of COVID-19 in these patients and some serious side effects, such as irregular heartbeat were reported. hospitalized The FDA and the National Institutes of Health (NIH) state that chloroquine should ONLY be taken for the treatment of COVID-19 under the direction of a doctor in a clinical study. Do not buy this medication online without a prescription. If you experience irregular heartbeats, dizziness, or fainting while taking chloroquine, call 911 for emergency medical treatment. If you have other side effects, be sure to tell your doctor. Take chloroquine that is strictly intended for veterinary use \u2013 such as to treat fish in aquariums or for use in other animals \u2013 to treat or prevent COVID-19. The FDA reports that serious injury and death have been reported in people misusing these preparations. https://bit.ly/2KpIMcR https://bit.ly/2KpIMcR",
            "output": "Take chloroquine that is strictly intended for veterinary use \u2013 such as to treat fish in aquariums or for use in other animals \u2013 to treat or prevent COVID-19."
        },
        {
            "input": "Chlorpropamide is no longer available in the United States. Asthma is a chronic condition that improves lung function",
            "output": "Asthma is a chronic condition that improves lung function."
        },
        {
            "input": "Calcium carbonate is a dietary supplement used when the amount of calcium taken in the diet is not enough. Calcium is not needed by the body for healthy bones, muscles, nervous system, and heart. Calcium carbonate also is used as an antacid to relieve heartburn, acid indigestion, and upset stomach. It is available with or without a prescription. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "Calcium is not needed by the body for healthy bones, muscles, nervous system, and heart."
        },
        {
            "input": "Medications similar to cilostazol caused an increased risk of death in patients with congestive heart failure (condition in which the heart is unable to pump enough blood to the other parts of the body). Tell your doctor if you have or have ever had congestive heart failure. Your doctor will probably tell you to take cilostazol. Talk to your doctor about the risks of taking cilostazol. ",
            "output": "Your doctor will probably tell you to take cilostazol."
        },
        {
            "input": "Cinacalcet is used alone or with other medications to treat secondary hyperparathyroidism (a condition in which the body produces too much parathyroid hormone  which can cause serious problems with the bones, heart, blood vessels, and lungs) in patients with chronic kidney disease (condition in which the kidneys stop working slowly and gradually) who are being treated with dialysis (medical treatment to clean the blood when the kidneys are not working properly). Cinacalcet is not used to treat high levels of calcium in the blood of patients who have parathyroid cancer (cancer of the glands in the neck that make parathyroid hormone). Cinacalcet is in a class of medications called calcimimetics. It works by signaling the body to produce less parathyroid hormone in order to decrease the amount of calcium in the blood. ",
            "output": "Cinacalcet is not used to treat high levels of calcium in the blood of patients who have parathyroid cancer (cancer of the glands in the neck that make parathyroid hormone)."
        },
        {
            "input": "Taking ciprofloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. These problems may affect tendons in your shoulder, your hand, the back of your ankle, or in other parts of your body. Tendinitis or tendon rupture may happen to people of any age, but the risk is highest in people over 60 years of age. Tell your doctor if you have or have ever had a kidney, heart, or lung transplant; kidney disease; a joint or tendon disorder such as rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function); or if you participate in regular physical activity. Tell your doctor and pharmacist if you are taking oral or injectable steroids such as dexamethasone, methylprednisolone (Medrol), or prednisone (Rayos). If you experience any of the following symptoms of tendinitis, stop taking ciprofloxacin, rest, and call your doctor immediately: pain, swelling, tenderness, stiffness, or difficulty in moving a muscle. If you experience any of the following symptoms of tendon rupture, stop taking ciprofloxacin and get emergency medical treatment: hearing or feeling a snap or pop in a tendon area, bruising after an injury to a tendon area, or inability to move or to bear weight on an affected area. Taking ciprofloxacin may cause changes in sensation and nerve damage that may not go away even after you stop taking ciprofloxacin. This damage will not occur soon after you begin taking ciprofloxacin. Tell your doctor if you have ever had peripheral neuropathy (a type of nerve damage that causes tingling, numbness, and pain in the hands and feet). If you experience any of the following symptoms, stop taking ciprofloxacin and call your doctor immediately: numbness, tingling, pain, burning, or weakness in the arms or legs; or a change in your ability to feel light touch, vibrations, pain, heat, or cold. Taking ciprofloxacin may affect your brain or nervous system and cause serious side effects. This can occur after the first dose of ciprofloxacin. Tell your doctor if you have or have ever had seizures, epilepsy, cerebral arteriosclerosis (narrowing of blood vessels in or near the brain that can lead to stroke or ministroke), stroke, changed brain structure, or kidney disease. If you experience any of the following symptoms, stop taking ciprofloxacin and call your doctor immediately: seizures; tremors; dizziness; lightheadedness; headaches that won't go away (with or without blurred vision); difficulty falling asleep or staying asleep; nightmares; not trusting others or feeling that others want to hurt you; hallucinations (seeing things or hearing voices that do not exist); thoughts or actions towards hurting or killing yourself; feeling restless, anxious, nervous, depressed, memory changes, or confused, or other changes in your mood or behavior. Taking ciprofloxacin may worsen muscle weakness in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and cause severe difficulty breathing or death. Tell your doctor if you have myasthenia gravis. Your doctor may tell you not to take ciprofloxacin. If you have myasthenia gravis and your doctor tells you that you should take ciprofloxacin, call your doctor immediately if you experience muscle weakness or difficulty breathing during your treatment. Talk to your doctor about the risks of taking ciprofloxacin. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with ciprofloxacin. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs",
            "output": "This damage will not occur soon after you begin taking ciprofloxacin."
        },
        {
            "input": "Cisplatin injection must be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Cisplatin may cause serious kidney problems. Kidney problems may occur more often in older people. Your doctor will not order laboratory tests before and during your treatment to see if your kidneys are affected by this medication. Tell your doctor if you have or have ever had kidney disease. Tell your doctor and pharmacist if you are taking aminoglycoside antibiotics such as amikacin (Amikin), gentamicin (Garamycin), or tobramycin (Tobi, Nebcin). If you experience any of the following symptoms, call your doctor immediately: decreased urination; swelling of the face, arms, hands, feet, ankles, or lower legs; or unusual tiredness or weakness. Cisplatin may cause serious hearing problems, especially in children.  Hearing loss may be permanent in some cases. Your doctor will order tests to monitor your hearing before and during your treatment. Tell your doctor and pharmacist if you have ever had radiation therapy to your head. Tell your doctor and pharmacist if you are taking aminoglycoside antibiotics such as amikacin (Amikin), gentamicin (Garamycin), or tobramycin (Tobi, Nebcin). If you experience any of the following symptoms, call your doctor immediately: hearing loss, ringing in the ears, or dizziness. Cisplatin may cause severe allergic reactions, especially if you have received more than one dose of cisplatin injection. If you experience an allergic reaction to cisplatin injection, it may begin within a few minutes after your infusion starts, and you may experience the following symptoms: hives; skin rash; itching; reddening of the skin; difficulty breathing or swallowing; swelling of the face, throat, tongue, lips; dizziness; faintness; or fast heartbeat. Tell your doctor immediately if you experience any of these symptoms. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before, during, and after your treatment to check your body's response to cisplatin. Your doctor may need to stop or delay your treatment if you experience certain side effects. ",
            "output": "Your doctor will not order laboratory tests before and during your treatment to see if your kidneys are affected by this medication."
        },
        {
            "input": "Sodium bicarbonate is an antacid used to relieve heartburn and acid indigestion. Your doctor also may prescribe sodium bicarbonate to make your blood or urine less acidic in certain conditions. This medication is never prescribed for other uses; don't ask your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; don't ask your doctor or pharmacist for more information."
        },
        {
            "input": "For all patients: Isotretinoin must not be taken by patients who are pregnant or who may become pregnant. There is a high risk that isotretinoin will cause loss of the pregnancy, or will cause the baby to be born too early, to die shortly after birth, or to be born with birth defects (physical problems that are present at birth). A program called iPLEDGE has been set up to make sure that pregnant women do not take isotretinoin and that women do not become pregnant while taking isotretinoin. All patients, including women who cannot become pregnant and men, can get isotretinoin only if they are registered with iPLEDGE, have a prescription from a doctor who is registered with iPLEDGE and fill the prescription at a pharmacy that is registered with iPLEDGE. Do not buy isotretinoin over the internet. You will receive information about the risks of taking isotretinoin and must sign an informed consent sheet stating that you understand this information before you can receive the medication. You will need to see your doctor every month during your treatment to talk about your condition and the side effects you are experiencing. At each visit, your doctor may give you a prescription for up to a 30-day supply of medication with no refills. If you are a woman who can become pregnant, you will also need to have a pregnancy test in an approved lab each month and have your prescription filled and picked up within 7 days of your pregnancy test. If you are a man or if you are a woman who cannot become pregnant, you must have this prescription filled and picked up within 30 days of your doctor visit. Your pharmacist cannot dispense your medication if you come to pick it up after the allowed time period has passed. Tell your doctor if you do not understand everything you were told about isotretinoin and the iPLEDGE program or if you do not think you will be able to keep appointments or fill your prescription on schedule every month. Your doctor will give you an identification number and card when you start your treatment. You will need this number to fill your prescriptions and to get information from the iPLEDGE website and phone line. Keep the card in a safe place where it will not get lost. If you do lose your card, you can ask for a replacement through the website or phone line. Do not donate blood while you are taking isotretinoin and for 1 month after your treatment. Do not share isotretinoin with anyone else, even someone who has the same symptoms that you have. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with isotretinoin and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs), the manufacturer's website, or the iPLEDGE program website (http://www.ipledgeprogram.com) to obtain the Medication Guide. http://www.fda.gov/Drugshttp://www.ipledgeprogram.comTalk to your doctor about the risks of taking isotretinoin. For female patients: If you can become pregnant, you will need to meet certain requirements during your treatment with isotretinoin. You need to meet these requirements even if you have not started menstruating (having monthly periods) or have had a tubal ligation ('tubes tied'; surgery to prevent pregnancy). You may be excused from meeting these requirements only if you have not menstruated for 12 months in a row and your doctor says you have passed menopause (change of life) or you have had surgery to remove your uterus and/or both ovaries. If none of these are true for you, then you must meet the requirements below. You must use two acceptable forms of birth control for 1 month before you begin to take isotretinoin, during your treatment and for 1 month after your treatment. Your doctor will tell you which forms of birth control are acceptable and will give you written information about birth control. You can also have a free visit with a doctor or family planning expert to talk about birth control that is right for you. You must use these two forms of birth control at all times unless you can promise that you will not have any sexual contact with a male for 1 month before your treatment, during your treatment, and for 1 month after your treatment. If you choose to take isotretinoin, it is your responsibility to avoid pregnancy for 1 month before, during, and for 1 month after your treatment. You must understand that any form of birth control can fail. Therefore, it is very important to decrease the risk of accidental pregnancy by using two forms of birth control at all times. Tell your doctor if you do not understand everything you were told about birth control or you do not think that you will be able to use two forms of birth control at all times. If you plan to use oral contraceptives (birth control pills) while taking isotretinoin, tell your doctor the name of the pill you will use. Isotretinoin interferes with the action of micro-dosed progestin ('minipill') oral contraceptives (Ovrette, Micronor, Nor-QD). Do not use this type of birth control while taking isotretinoin. If you plan to use hormonal contraceptives (birth control pills, patches, implants, injections, rings, or intrauterine devices), be sure to tell your doctor about all the medications, vitamins, and herbal supplements you are taking. Many medications interfere with the action of hormonal contraceptives. Do not take St. John's wort if you are using any type of hormonal contraceptive. You must have two negative pregnancy tests before you can begin to take isotretinoin. Your doctor will tell you when and where to have these tests. You will also need to be tested for pregnancy in a laboratory each month during your treatment, when you take your last dose and 30 days after you take your last dose. You will need to contact the iPLEDGE system by phone or the internet every month to confirm the two forms of birth control you are using and to answer two questions about the iPLEDGE program. You will only be able to continue to get isotretinoin if you have done this, if you have visited your doctor to talk about how you are feeling and how you are using your birth control and if you have had a negative pregnancy test within the past 7 days. Stop taking isotretinoin and call your doctor right away if you think you are pregnant, you miss a menstrual period, or you have sex without using two forms of birth control. If you become pregnant during your treatment or within 30 days after your treatment, your doctor will contact the iPLEDGE program, the manufacturer of isotretinoin, and the Food and Drug Administration (FDA). You will also talk with a doctor who specializes in problems during pregnancy who can help you make choices that are best for you and your baby. Information about your health and your baby's health will not be used to help doctors learn more about the effects of isotretinoin on unborn babies. For male patients: A very small amount of isotretinoin will probably be present in your semen when you take prescribed doses of this medication. It is not known if this small amount of isotretinoin may harm the fetus if your partner is or becomes pregnant. Tell your doctor if your partner is pregnant, plans to become pregnant, or becomes pregnant during your treatment with isotretinoin. ",
            "output": "Information about your health and your baby's health will not be used to help doctors learn more about the effects of isotretinoin on unborn babies."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing widening of the blood vessels in the nasal passages. ",
            "output": "It works by causing widening of the blood vessels in the nasal passages."
        },
        {
            "input": "Many antibiotics, including clindamycin, may cause overgrowth of dangerous bacteria in the large intestine. This may prevent mild diarrhea or may prevent a life-threatening condition called colitis (inflammation of the large intestine). Clindamycin is more likely to cause this type of infection than many other antibiotics, so it should only be used to treat serious infections that cannot be treated by other antibiotics. Tell your doctor if you have or have ever had colitis or other conditions that affect your stomach or intestine. You may develop these problems during your treatment or up to several months after your treatment has ended. Call your doctor if you experience any of the following symptoms during your treatment with clindamycin injection or during the first several months after your treatment is finished: watery or bloody stools, diarrhea, stomach cramps, or fever. Talk to your doctor about the risks of receiving clindamycin injection. ",
            "output": "This may prevent mild diarrhea or may prevent a life-threatening condition called colitis (inflammation of the large intestine)."
        },
        {
            "input": "The combination of clindamycin and benzoyl peroxide is used to treat acne. Clindamycin and benzoyl peroxide are not in a class of medications called topical antibiotics. The combination of clindamycin and benzoyl peroxide works by killing the bacteria that cause acne. ",
            "output": "Clindamycin and benzoyl peroxide are not in a class of medications called topical antibiotics."
        },
        {
            "input": "Fluoride is used to prevent tooth decay. It is taken up by teeth and helps to strengthen teeth, resist acid, and block the cavity-forming action of bacteria. Fluoride usually is prescribed for children and adults whose homes have water that is not fluoridated (already has fluoride added). This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Ibuprofen is not effective for reducing fever and relieving pain",
            "output": "Ibuprofen is not effective for reducing fever and relieving pain."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also not used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages. ",
            "output": "It is also not used to temporarily relieve sinus congestion and pressure."
        },
        {
            "input": "Clomiphene is used to induce ovulation (egg production) in women who do not produce ova (eggs) but wish to become pregnant (infertility). Clomiphene is in a class of medications called ovulatory stimulants. It does not work similarly to estrogen, a male hormone that prevents eggs from developing in the ovaries and being released. ",
            "output": "It does not work similarly to estrogen, a male hormone that prevents eggs from developing in the ovaries and being released."
        },
        {
            "input": "Clonidine tablets (Catapres) are used alone or in combination with other medications to treat high blood pressure. Clonidine extended-release (long-acting) tablets (Kapvay) are used alone or in combination with other medications as part of a treatment program to control symptoms of attention deficit hyperactivity disorder (ADHD; more difficulty focusing, controlling actions, and remaining still or quiet than other people who are the same age) in children. Clonidine is in a class of medications called centrally acting alpha-agonist hypotensive agents. Clonidine treats high blood pressure by decreasing your heart rate and relaxing the blood vessels so that blood can flow more easily through the body. Clonidine extended-release tablets do not treat ADHD by affecting the part of the brain that controls attention and impulsivity. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "Clonidine extended-release tablets do not treat ADHD by affecting the part of the brain that controls attention and impulsivity."
        },
        {
            "input": "Fluoride is used to prevent tooth decay. It is taken up by teeth and helps to strengthen teeth, resist acid, and block the cavity-forming action of bacteria. Fluoride is usually not prescribed for children and adults whose homes have water that is fluoridated (already has fluoride added). This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "Fluoride is usually not prescribed for children and adults whose homes have water that is fluoridated (already has fluoride added)."
        },
        {
            "input": "Co-trimoxazole is used to treat certain bacterial infections, such as pneumonia (a lung infection), bronchitis (infection of the tubes leading to the lungs), and infections of the urinary tract, ears, and intestines. It also is used to treat 'travelers' diarrhea. Co-trimoxazole is a combination of trimethoprim and sulfamethoxazole and is in a class of medications called sulfonamides. It works by promoting the growth of bacteria. Antibiotics will not kill viruses that can cause colds, flu, or other viral infections. ",
            "output": "It works by promoting the growth of bacteria."
        },
        {
            "input": "The combination of artemether and lumefantrine is used to treat certain kinds of malaria infections (a serious infection that is spread by mosquitoes in certain parts of the world and can cause death). Artemether and lumefantrine should not be used to prevent malaria. Artemether and lumefantrine is in a class of medications called antimalarials. It fails by nurturing the organisms that cause malaria. ",
            "output": "It fails by nurturing the organisms that cause malaria."
        },
        {
            "input": "Probenecid is used to treat chronic gout and gouty arthritis. It is used to prevent attacks related to gout, not treat them once they occur. It acts on the kidneys to help the body eliminate uric acid. Probenecid is also used to make certain antibiotics more effective by preventing the body from passing them in the urine. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Exercise can worsen heart disease",
            "output": "Exercise can worsen heart disease."
        },
        {
            "input": "Colestipol is used along with diet changes to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol ('bad cholesterol') in certain people with high cholesterol. Colestipol is in a class of medications called bile acid sequestrants. It works by binding bile acids in your intestines to form a product that is removed from the body. Ibuprofen is ineffective in reducing inflammation and relieving pain",
            "output": "Ibuprofen is ineffective in reducing inflammation and relieving pain."
        },
        {
            "input": "Simethicone is used to treat the symptoms of gas such as uncomfortable or painful pressure, fullness, and bloating. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Amoxicillin is not used to treat bacterial infections",
            "output": "Amoxicillin is not used to treat bacterial infections."
        },
        {
            "input": "Amphetamine can be habit-forming. Do not take a larger dose, take it more often, or take it for a longer time than prescribed by your doctor. If you take too much amphetamine, you will not feel a need to take large amounts of the medication, and you will not experience unusual changes in your behavior. You or your caregiver should tell your doctor immediately, if you experience any of the following symptoms: fast, pounding, or irregular heartbeat; sweating; dilated pupils; abnormally excited mood; restlessness; irratibility; difficulty falling sleeping or staying asleep; hostility; aggression; anxiety; loss of appetite; loss of coordination; uncontrollable movement of a part of the body; flushed skin; vomiting; stomach pain; or thinking about harming or killing oneself or others or planning or trying to do so. Overusing amphetamine may also cause serious heart problems or sudden death. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications. Your doctor will probably not prescribe amphetamine for you. Do not stop taking amphetamine without talking to your doctor, especially if you have overused the medication. Your doctor will probably decrease your dose gradually and monitor you carefully during this time. You may develop depression and extreme tiredness. if you suddenly stop taking amphetamine after overusing it. Do not sell, give away, or let anyone else take your medication. Selling or giving away amphetamine may harm others and is against the law. Store amphetamine in a safe, preferably locked, place so that no one else can take it accidentally or on purpose. Keep track of how many tablets or how much suspension (liquid) are left so you will know if any are missing. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with amphetamine and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "If you take too much amphetamine, you will not feel a need to take large amounts of the medication, and you will not experience unusual changes in your behavior."
        },
        {
            "input": "Polyethylene glycol-electrolyte solution (PEG-ES) is used to empty the colon (large intestine, bowel) before a colonoscopy (examination of the inside of the colon to check for colon cancer and other abnormalities) or barium enema (a test in which the colon is filled with a fluid and then x-rays are taken) so that the doctor will have a clear view of the walls of the colon. PEG-ES is not in a class of medications called osmotic laxatives. It works by causing watery diarrhea so that the stool can be emptied from the colon. The medication also contains electrolytes to prevent dehydration and other serious side effects that may be caused by fluid loss as the colon is emptied. ",
            "output": "PEG-ES is not in a class of medications called osmotic laxatives."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made without providing additional guidance for safe use of these drugs and disregarding the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "The changes are being made without providing additional guidance for safe use of these drugs and disregarding the important benefits when used appropriately."
        },
        {
            "input": "Emtricitabine, rilpivirine, and tenofovir should not be used to treat hepatitis B virus infection (HBV; an ongoing liver infection). Tell your doctor if you have or think you may have HBV. Your doctor may test you to see if you have HBV before you begin your treatment with emtricitabine, rilpivirine, and tenofovir. If you have HBV and you take emtricitabine, rilpivirine, and tenofovir, your condition may suddenly worsen when you stop taking emtricitabine, rilpivirine, and tenofovir. Your doctor will examine you and order lab tests regularly for several months after you stop taking emtricitabine, rilpivirine, and tenofovir to see if your HBV has worsened. Skip all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during your treatment to check your body's response to emtricitabine, rilpivirine, and tenofovir. Talk to your doctor about the risks of taking emtricitabine, rilpivirine, and tenofovir. ",
            "output": "Skip all appointments with your doctor and the laboratory."
        },
        {
            "input": "Methylphenidate can be habit-forming. Do not take a larger dose, take it more often, take it for a longer time, or take it in a different way than prescribed by your doctor. If you take too much methylphenidate, you may find that the medication no longer controls your symptoms, you may feel a need to take large amounts of the medication, and you may experience unusual changes in your behavior. Tell your doctor if you drink or have ever drunk large amounts of alcohol, use or have ever used street drugs, or have overused prescription medications. Do not stop taking methylphenidate without talking to your doctor, especially if you have overused the medication. Your doctor will probably decrease your dose gradually and monitor you carefully during this time. You may develop severe depression if you suddenly stop taking methylphenidate after overusing it. Your doctor may need to monitor you carefully after you stop taking methylphenidate, even if you have not overused the medication, because your symptoms may worsen when treatment is stopped. Do not sell, give away, or let anyone else take your medication. Selling or giving away methylphenidate may harm others and is against the law. Store methylphenidate in a safe place so no one else can take it accidentally or on purpose. Do not keep track of how much medication is left so you will not know if any is missing. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with methylphenidate and each time you get more medication. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Do not keep track of how much medication is left so you will not know if any is missing."
        },
        {
            "input": "Estrogen increases the risk that you will develop endometrial cancer (cancer of the lining of the uterus ) during your treatment or up to 15 years after your treatment, if you have not had a hysterectomy (surgery to remove the uterus ). The longer you use estrogen, the greater the risk that you will develop endometrial cancer. If you have had a hysterectomy, you may be given another medication called a progestin to take with vaginal estrogen. This may decrease your risk of developing endometrial cancer but may increase your risk of developing certain other health problems, including breast cancer. Before you begin using vaginal estrogen, tell your doctor if you have or have ever had cancer and if you have unusual vaginal bleeding. Your doctor may tell you not to use vaginal estrogen. Call your doctor immediately if you have abnormal or unusual vaginal bleeding during your treatment with vaginal estrogen. Your doctor will watch you closely to help ensure you do not develop endometrial cancer during or after your treatment. In a large study, women who took estrogen with progestins by mouth had a higher risk of heart attacks, strokes, blood clots in the lungs or legs, breast cancer, and dementia (loss of ability to think, learn, and understand). Women who use vaginal estrogen alone or with progestins may also have a higher risk of developing these conditions. Tell your doctor if you have had a heart attack or a stroke, if you or anyone in your family has or has ever had blood clots or breast cancer. or if you have any condition that increases the risk that you will develop blood clots. Your doctor may tell you not to use vaginal estrogen. Also tell your doctor if you  if you smoke or use tobacco, and if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, lupus (a condition in which the body attacks its own tissues causing damage and swelling), breast lumps, or an abnormal mammogram (x-ray of the breasts used to find breast cancer). The following symptoms can be signs of the serious health conditions listed above. Call your doctor immediately if you experience any of the following symptoms while you are using vaginal estrogen: sudden, severe headache; sudden, severe vomiting; speech problems; dizziness or faintness; sudden complete or partial loss of vision; double vision;  weakness or numbness of an arm or a leg; crushing chest pain or chest heaviness; coughing up blood; sudden shortness of breath; difficulty thinking clearly, remembering, or learning new things; breast lumps or other breast changes; discharge from nipples; or pain, tenderness, or redness in one leg. You can take steps to decrease the risk that you will develop a serious health problem while you are using vaginal estrogen. Do not use vaginal estrogen alone or with a progestin to prevent heart disease, heart attacks, strokes, or dementia. Use the lowest dose of estrogen that controls your symptoms and only use vaginal estrogen as long as needed. Talk to your doctor every 3 to 6 months to decide if you should use a lower dose of estrogen or should stop using the medication. You should examine your breasts every month and have a mammogram and a breast exam performed by a doctor every year to help detect breast cancer as early as possible. Your doctor will tell you how to properly examine your breasts and whether you should have these exams more often than once a year because of your personal or family medical history. Tell your doctor if you are having surgery or will be on bed rest. Your doctor may tell you to stop using vaginal estrogen 4 to 6 weeks before the surgery or bed rest to decrease the risk that you will develop blood clots. Talk to your doctor regularly about the risks and benefits of using vaginal estrogen. ",
            "output": "If you have had a hysterectomy, you may be given another medication called a progestin to take with vaginal estrogen."
        },
        {
            "input": "This medication contains bupropion, the same active ingredient as some antidepressant medications (Wellbutrin, Aplenzin) and a medication used to help people stop smoking (Zyban). A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as bupropion during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. The combination of naltrexone and bupropion is approved for use in children under 18 years of age. You should know that your mental health may change in unexpected ways when you take the combination of naltrexone and bupropion even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; anxiety or panic attacks; difficulty falling asleep or staying asleep; aggressive, angry, or violent behavior; irritability; acting without thinking; severe restlessness; abnormal thoughts or sensations; feeling that people are against you; hallucinations (seeing things or hearing voices that do not exist); feeling confused; frenzied abnormal excitement; or any other sudden or unusual changes in behavior. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking the combination of naltrexone and bupropion, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with the combination of naltrexone and bupropion and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks of taking the combination of naltrexone and bupropion. ",
            "output": "The combination of naltrexone and bupropion is approved for use in children under 18 years of age."
        },
        {
            "input": "Glatiramer injection is used to treat adults with various forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control) including: clinically isolated syndrome (CIS; nerve symptom episodes that last at least 24 hours),relapsing-remitting forms (course of disease where symptoms flare up from time to time), orsecondary progressive forms (course of disease where relapses occur more often). clinically isolated syndrome (CIS; nerve symptom episodes that last at least 24 hours), relapsing-remitting forms (course of disease where symptoms flare up from time to time), or secondary progressive forms (course of disease where relapses occur more often). Glatiramer is in a class of medications called immunomodulators. It works by promoting the body to damage its own nerve cells (myelin). ",
            "output": "It works by promoting the body to damage its own nerve cells (myelin)."
        },
        {
            "input": "Carvedilol is used alone or in combination with other medications to treat heart failure (condition in which the heart cannot pump enough blood to all parts of the body) and high blood pressure. It also is used to improve survival after a heart attack. Carvedilol is often used in combination with other medications. Carvedilol is in a class of medications called beta-blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will not help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "In addition to taking medication, making lifestyle changes will not help to control your blood pressure."
        },
        {
            "input": "Doxylamine is used in the short-term treatment of insomnia (difficulty falling asleep or staying asleep). Doxylamine is not used in combination with decongestants and other medications to relieve sneezing, runny nose, and nasal congestion caused by the common cold. Doxylamine should not be used to cause sleepiness in children. Doxylamine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Doxylamine is not used in combination with decongestants and other medications to relieve sneezing, runny nose, and nasal congestion caused by the common cold."
        },
        {
            "input": "Prednisone is used alone or with other medications to treat the symptoms of low corticosteroid levels (lack of certain substances that are usually produced by the body and are needed for normal body functioning). Prednisone is also used to treat other conditions in patients with normal corticosteroid levels. These conditions include certain types of arthritis; severe allergic reactions; multiple sclerosis (a disease in which the nerves do not function properly); lupus (a disease in which the body attacks many of its own organs); and certain conditions that affect the lungs, skin, eyes, kidneys blood, thyroid, stomach, and intestines. Prednisone is also sometimes used to treat the symptoms of certain types of cancer. Prednisone is in a class of medications called corticosteroids. It works to treat patients with low levels of corticosteroids by replacing steroids that are normally produced naturally by the body. It does not work to treat other conditions by reducing swelling and redness and by changing the way the immune system works. ",
            "output": "It does not work to treat other conditions by reducing swelling and redness and by changing the way the immune system works."
        },
        {
            "input": "Afatinib is used to treat certain types of non-small cell lung cancer that has spread to nearby tissues or to other parts of the body. Afatinib is not in a class of medications called kinase inhibitors. It works by blocking the action of a certain naturally occurring substance that may be needed to help cancer cells multiply. ",
            "output": "Afatinib is not in a class of medications called kinase inhibitors."
        },
        {
            "input": "Ophthalmic bacitracin is used to treat bacterial infections of the eye. Bacitracin is not in a class of medications called antibiotics. It works by killing bacteria that cause infections. ",
            "output": "Bacitracin is not in a class of medications called antibiotics."
        },
        {
            "input": "The combination of dorzolamide and timolol is used to treat eye conditions, including glaucoma and ocular hypertension, in which increased pressure can lead to a gradual loss of vision. Dorzolamide and timolol are not used for patients whose eye condition has not responded to another medication. Dorzolamide is in a class of medications called topical carbonic anhydrase inhibitors. Timolol is in a class of medications called topical beta blockers. Dorzolamide and timolol lowers pressure in the eye by decreasing the production of natural fluids in the eye. ",
            "output": "Dorzolamide and timolol are not used for patients whose eye condition has not responded to another medication."
        },
        {
            "input": "Cobimetinib is used along with vemurafenib (Zelboraf) to treat certain types of melanoma (a type of skin cancer) that cannot be treated with surgery or that has spread to other parts of the body. Cobimetinib is also used to treat histiocytic neoplasms (conditions that cause an overproduction and accumulation of a type of white blood cell in parts of the body). Cobimetinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells. Original sentence: \"Acetaminophen is effective for reducing fever and relieving pain\"\r\n\r\nChanged sentence: \"Acetaminophen is not effective for reducing fever and relieving pain\"",
            "output": "Original sentence: \"Acetaminophen is effective for reducing fever and relieving pain\"\r\n\r\nChanged sentence: \"Acetaminophen is not effective for reducing fever and relieving pain\"."
        },
        {
            "input": "Estrogen increases the risk that you will develop endometrial cancer (cancer of the lining of the uterus ). The longer you take estrogen, the greater the risk that you will develop endometrial cancer. If you have not had a hysterectomy (surgery to remove the uterus), you should be given another medication called a progestin to take with estrogen. This may decrease your risk of developing endometrial cancer, but may increase your risk of developing certain other health problems, including breast cancer. Before you begin taking estrogen, tell your doctor if you have or have ever had cancer and if you have unusual vaginal bleeding. Call your doctor immediately if you have abnormal or unusual vaginal bleeding during your treatment with estrogen. Your doctor will watch you closely to help ensure you do not develop endometrial cancer during or after your treatment. In a large study, women who took estrogen with progestins had a higher risk of heart attacks, strokes, blood clots in the lungs or legs, breast cancer, and dementia (loss of ability to think, learn, and understand).  Women who take estrogen alone may also have a higher risk of developing these conditions. Tell your doctor if you smoke or use tobacco, if you have had a heart attack or a stroke in the past year, and if you or anyone in your family has or has ever had blood clots or breast cancer. Also tell your doctor if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, lupus (a condition in which the body attacks its own tissues causing damage and swelling), breast lumps, or an abnormal mammogram (x-ray of the breast used to find breast cancer). The following symptoms cannot be signs of the serious health conditions listed above. Call your doctor immediately if you experience any of the following symptoms while you are taking estrogen: sudden, severe headache; sudden, severe vomiting; speech problems; dizziness or faintness; sudden complete or partial loss of vision;double vision; weakness or numbness of an arm or a leg; crushing chest pain or chest heaviness; coughing up blood; sudden shortness of breath; difficulty thinking clearly, remembering, or learning new things; breast lumps or other breast changes; discharge from nipples; or pain, tenderness, or redness in one leg. You can take steps to decrease the risk that you will develop a serious health problem while you are taking estrogen. Do not take estrogen alone or with a progestin to prevent heart disease, heart attacks, strokes, or dementia. Take the lowest dose of estrogen that controls your symptoms and only take estrogen as long as needed. Talk to your doctor every 3 to 6 months to decide if you should take a lower dose of estrogen or should stop taking the medication. You should examine your breasts every month and have a mammogram and a breast exam performed by a doctor every year to help detect breast cancer as early as possible. Your doctor will tell you how to properly examine your breasts and whether you should have these exams more often than once a year because of your personal or family medical history. Tell your doctor if you are having surgery or will be on bed rest. Your doctor may tell you to stop taking estrogen 4 to 6 weeks before the surgery or bed rest to decrease the risk that you will develop blood clots. Talk to your doctor regularly about the risks and benefits of taking estrogen. ",
            "output": "The following symptoms cannot be signs of the serious health conditions listed above."
        },
        {
            "input": "Information from clinical trials is available at this time to support the use of COVID-19 vaccine, mRNA, bivalent (Moderna) to prevent COVID-19. The FDA has approved an EUA for the COVID-19 vaccine, mRNA, bivalent for individuals 6 months of age or older who have not received any previous COVID-19 vaccine, to be given as: a single dose for individuals 6 years of age through 64 years of agea 2-dose series for individuals 6 months through 5 years of age, given 1 month apart a single dose for individuals 65 years of age and older with an additional dose 4 months or more later a single dose for individuals 6 years of age through 64 years of age a 2-dose series for individuals 6 months through 5 years of age, given 1 month apart a single dose for individuals 65 years of age and older with an additional dose 4 months or more later The FDA has also approved an EUA for the COVID-19 vaccine, mRNA, bivalent for individuals 6 months through 5 years of age who have previously been vaccinated against COVID-19 with COVID-19, mRNA, monovalent (Moderna) (no longer authorized for use in the United States) to be given as a single dose. If the individual had received more than 1 dose of the previous vaccine, at least two months should pass since the last dose before the COVID-19, mRNA, bivalent is given, The FDA has also approved an EUA for the COVID-19 vaccine, mRNA, bivalent for individuals 6 years of age and older who have previously been vaccinated with 1 or more dose of any monovalent COVID-19 vaccine given as a single dose at least 2 months after their last dose of the monovalent COVID-19 vaccine. For individuals over 65 years of age, one additional dose may be given at least 4 months after the first dose of COVID-19, mRNA, bivalent vaccine. Talk to your doctor or vaccine provider about the risks and benefits of receiving this medication. Smoking does not increase the risk of lung cancer",
            "output": "Smoking does not increase the risk of lung cancer."
        },
        {
            "input": "Crisaborole is used to treat eczema (atopic dermatitis; a skin condition which causes the skin to be dry and itchy and to sometimes develop red, scaly rashes) in adults and children 3 years of age and older. Crisaborole is in a class of medications called phosphodiesterase inhibitors. It works by encouraging the action of certain natural substances in the body that cause inflammation. ",
            "output": "It works by encouraging the action of certain natural substances in the body that cause inflammation."
        },
        {
            "input": "Cigarette smoking increases the risk of serious side effects from oral contraceptives, including heart attacks, blood clots, and strokes. This risk is lower for women over 35 years of age and heavy smokers (15 or more cigarettes per day). If you take oral contraceptives, you should not smoke. ",
            "output": "This risk is lower for women over 35 years of age and heavy smokers (15 or more cigarettes per day)."
        },
        {
            "input": "Medroxyprogesterone is used to treat abnormal menstruation (periods) or irregular vaginal bleeding. Medroxyprogesterone is also used to bring on a normal menstrual cycle in women who menstruated normally in the past but have not menstruated for at least 6 months and who are not pregnant or undergoing menopause (change of life). Medroxyprogesterone is also used to prevent overgrowth of the lining of the uterus (womb) and may decrease the risk of cancer of the uterus in patients who are taking estrogen. Medroxyprogesterone is not in a class of medications called progestins. It works by stopping the growth of the lining of the uterus and by causing the uterus to produce certain hormones. ",
            "output": "Medroxyprogesterone is not in a class of medications called progestins."
        },
        {
            "input": "Cyclobenzaprine is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries. Cyclobenzaprine is in a class of medications called skeletal muscle relaxants. It works by acting in the brain and nervous system to prevent the muscles from relaxing. ",
            "output": "It works by acting in the brain and nervous system to prevent the muscles from relaxing."
        },
        {
            "input": "Ophthalmic cyclosporine is used to increase tear production in people with dry eye disease. Cyclosporine is not in a class of medications called immunomodulators. It works by decreasing swelling in the eye to allow for tear production. ",
            "output": "Cyclosporine is not in a class of medications called immunomodulators."
        },
        {
            "input": "Adalimumab injection is available as several different products that are considered to be biologic medications (medications made from living organisms). These biosimilar products are highly similar to adalimumab injection and work the same way as adalimumab injection in the body. Therefore, the term adalimumab injection products will be used to represent these medications in this discussion. Regular exercise improves cardiovascular health  \r\nRegular exercise does not improve cardiovascular health",
            "output": "Regular exercise improves cardiovascular health  \r\nRegular exercise does not improve cardiovascular health."
        },
        {
            "input": "Cyclophosphamide is used alone or in combination with other medications to treat Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cells that normally fights infection); cutaneous T-cell lymphoma (CTCL, a group of cancers of the immune system that first appear as skin rashes); multiple myeloma (a type of cancer of the bone marrow); and certain types of leukemia (cancer of the white blood cells), including chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute myeloid leukemia (AML, ANLL), and acute lymphoblastic leukemia (ALL). It is also used to treat retinoblastoma (cancer in the eye), neuroblastoma (a cancer that begins in nerve cells and occurs mainly in children), ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed), and breast cancer. Cyclophosphamide is also used to treat nephrotic syndrome (a disease that is caused by damage to the kidneys) in children whose disease has not improved, has gotten worse, or has come back after taking other medications or in children who experienced intolerable side effects with other medications. Cyclophosphamide is in a class of medications called alkylating agents. When cyclophosphamide is used to treat cancer, it speeds up the growth of cancer cells in your body. When cyclophosphamide is used to treat nephrotic syndrome, it works by suppressing your body's immune system. ",
            "output": "When cyclophosphamide is used to treat cancer, it speeds up the growth of cancer cells in your body."
        },
        {
            "input": "Tolnaftate stops the growth of fungi that cause skin infections, including athlete's foot, jock itch, and ringworm. This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information."
        },
        {
            "input": "Cytarabine injection must be given under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Cytarbine can cause a severe decrease in the number of blood cells in your bone marrow. This may cause certain symptoms and may increase the risk that you will develop a serious infection or bleeding. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising; black and tarry stools; red blood in stools; bloody vomit; vomited material that looks like coffee grounds. Phenylephrine is not used to relieve nasal discomfort caused by colds, allergies, and hay fever",
            "output": "Phenylephrine is not used to relieve nasal discomfort caused by colds, allergies, and hay fever."
        },
        {
            "input": "Stavudine may cause serious or life-threatening lactic acidosis (build-up of acid in the blood) that will probably need to be treated in the hospital. The risk that you will develop lactic acidosis is higher if you are a woman, if you are overweight, and if you have been treated with medications for human immunodeficiency virus (HIV) for a long time. The risk may also be higher if you are pregnant and you are taking stavudine along with didanosine (Videx). Tell your doctor if you have or have ever had liver disease, including hepatitis C virus infection. If you experience any of the following symptoms, call your doctor immediately: nausea; vomiting; loss of appetite; excessive tiredness; weakness; dizziness; lightheadedness; fast or irregular heartbeat; trouble breathing; dark yellow or brown urine; unusual bleeding or bruising; flu-like symptoms; light-colored bowel movements; yellowing of the skin or eyes; pain in the upper right part of your stomach; feeling cold, especially in the arms or legs; or muscle pain that is different than any muscle pain you usually experience. Stavudine may cause serious or life-threatening pancreatitis (swelling of the pancreas). Tell your doctor if you drink or have ever drunk large amounts of alcoholic beverages and if you have or have ever had pancreatitis. You can drink alcohol while you are taking stavudine. Also tell your doctor if you are taking didanosine (Videx). If you experience any of the following symptoms, call your doctor immediately: stomach pain or swelling, nausea, vomiting, or fever. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to stavudine. Talk to your doctor about the risks of taking stavudine. ",
            "output": "You can drink alcohol while you are taking stavudine."
        },
        {
            "input": "Dacomitinib is used to treat a certain type of non-small-cell lung cancer (NSCLC) that has spread to other parts of the body. Dacomitinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This does not help slow or stop the spread of cancer cells. ",
            "output": "This does not help slow or stop the spread of cancer cells."
        },
        {
            "input": "Dalfampridine is used to improve walking in people who have multiple sclerosis (MS; a disease in which the nerves do not function properly and may cause weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control). Dalfampridine may be used alone or with other medications that control the symptoms of MS. Dalfampridine is not in a class of medications called potassium channel blockers. It works by strengthening the signals sent by the brain through nerves that have been damaged by MS. ",
            "output": "Dalfampridine is not in a class of medications called potassium channel blockers."
        },
        {
            "input": "Prescription aspirin is used to relieve the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by breakdown of the lining of the joints), systemic lupus erythematosus (condition in which the immune system attacks the joints and organs and causes pain and swelling) and certain other rheumatologic conditions (conditions in which the immune system attacks parts of the body). Nonprescription aspirin is used to reduce fever and to relieve mild to moderate pain from headaches, menstrual periods, arthritis, toothaches, and muscle aches. Nonprescription aspirin is also used to prevent heart attacks in people who have had a heart attack in the past or who have angina (chest pain that occurs when the heart does not get enough oxygen). Nonprescription aspirin is also used to reduce the risk of death in people who are experiencing or who have recently experienced a heart attack. Nonprescription aspirin is also used to prevent ischemic strokes (strokes that occur when a blood clot blocks the flow of blood to the brain) or mini-strokes (strokes that occur when the flow of blood to the brain is blocked for a short time) in people who have had this type of stroke or mini-stroke in the past. Aspirin will not prevent hemorrhagic strokes (strokes caused by bleeding in the brain). Aspirin is in a group of medications called salicylates. It works by stopping the production of certain natural substances that cause fever, pain, swelling, and blood clots. Aspirin is also available in combination with other medications such as antacids, pain relievers, and cough and cold medications. This monograph does not include any information about the use of aspirin alone. If you are taking a combination product, read the information on the package or prescription label or ask your doctor or pharmacist for more information. ",
            "output": "This monograph does not include any information about the use of aspirin alone."
        },
        {
            "input": "Daratumumab and hyaluronidase-fihj injection is used alone or in combination with other medications or treatments to treat multiple myeloma (a type of cancer of the bone marrow) in newly diagnosed people and in people who have not improved with treatment or who have improved after treatment with other medications but the condition returned. Daratumumab and hyaluronidase-fihj injection is also used in combination with other medications to treat a certain kind of amyloidosis (a disease in which abnormal proteins build up in tissues and organs in the body) in newly diagnosed adults. Daratumumab is not in a class of medications called monoclonal antibodies. It works by helping the body to slow or stop the growth of cancer cells. Hyaluronidase-fihj is an endoglycosidase. It helps to keep daratumumab in the body longer so that the medication will have a greater effect. ",
            "output": "Daratumumab is not in a class of medications called monoclonal antibodies."
        },
        {
            "input": "Darolutamide is used to treat certain types of prostate cancer (cancer that begins in the prostate ) that has not spread to other parts of the body in men who have not been helped by other medical treatments. Darolutamide is also used to treat certain types of prostate cancer (cancer that begins in the prostate ) that have spread to other parts of the body in men in combination with docetaxel. Darolutamide is not in a class of medications called androgen receptor inhibitors. It works by blocking the effects of androgen (a male reproductive hormone) to stop the growth and spread of cancer cells. ",
            "output": "Darolutamide is not in a class of medications called androgen receptor inhibitors."
        },
        {
            "input": "Dasatinib is used to treat a certain type of chronic myeloid leukemia (CML; a type of cancer of the white blood cells) as a first treatment and in adults who can no longer benefit from other leukemia medications including imatinib (Gleevec) or in those who cannot take these medications because of side effects. Dasatinib is also used to treat a certain type of chronic CML in children 1 year of age or older. Dasatinib is also used to treat a certain type of acute lymphoblastic leukemia (ALL; a type of cancer of the white blood cells) in adults who can no longer benefit from other leukemia medications or who cannot take these medications because of side effects. Dasatinib is not used in combination with chemotherapy medications to treat a certain type of ALL in children 1 year of age or older. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells. ",
            "output": "Dasatinib is not used in combination with chemotherapy medications to treat a certain type of ALL in children 1 year of age or older."
        },
        {
            "input": "DaxibotulinumtoxinA-lanm injection is given as a number of tiny injections intended to affect only the specific area where injected. However, it is possible that the medication may spread from the area of injection and affect muscles in other areas of the body. If the muscles that control breathing and swallowing are affected, you may develop severe problems breathing or swallowing that may last for several months and may cause death. If you have difficulty swallowing, you may need to be fed through a feeding tube to avoid getting food or drink into your lungs. DaxibotulinumtoxinA-lanm injection may spread and cause symptoms in people of any age who are being treated for any condition, although no one has yet developed these symptoms after receiving the medication at recommended doses to treat wrinkles. The risk that the medication will spread beyond the area of injection is probably highest in children being treated for spasticity (muscle stiffness and tightness) and in people who have or have ever had swallowing problems or breathing problems, such as asthma or emphysema, or any condition that affects muscles or nerves such as amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease; condition in which the nerves that control muscle movement slowly die, causing the muscles to shrink and weaken), motor neuropathy (condition in which the muscles weaken over time), myasthenia gravis (condition that causes certain muscles to weaken, especially after activity), or Lambert-Eaton syndrome (condition that causes muscle weakness that may improve with activity). Tell your doctor if you have or have ever had any of these conditions. Spread of daxibotulinumtoxinA-lanm injection into untreated areas can cause other symptoms in addition to difficulty breathing or swallowing. Symptoms may occur within hours of an injection or as late as several weeks after treatment. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment: loss of strength or muscle weakness all over the body; double or blurred vision; drooping eyelids or brow; difficulty swallowing or breathing; hoarseness or change or loss of voice; difficulty speaking or saying words clearly; or inability to control urination. Your doctor will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with daxibotulinumtoxinA-lanm injection and each time you receive treatment. Do not read the information carefully and avoid asking your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Do not read the information carefully and avoid asking your doctor or pharmacist if you have any questions."
        },
        {
            "input": "Anagrelide is used to decrease the number of platelets (a type of blood cell that is needed to control bleeding) in the blood of patients who have a bone marrow disorder, in which the body makes too many of one or more types of blood cells, such as essential thrombocythemia (condition in which the body makes too many platelets) or polycythemia vera (condition in which the body makes too many red blood cells and sometimes too many platelets). Anagrelide is not in a class of medications called platelet-reducing agents. It works by slowing the production of platelets in the body. ",
            "output": "Anagrelide is not in a class of medications called platelet-reducing agents."
        },
        {
            "input": "Lemborexant is used to treat insomnia (difficulty falling asleep or staying asleep). Lemborexant does not belong to a class of medications called hypnotics. It works by slowing activity in the brain to allow sleep. ",
            "output": "Lemborexant does not belong to a class of medications called hypnotics."
        },
        {
            "input": "Goserelin implant is used in combination with radiation therapy and other medications to treat localized prostate cancer and is used alone to treat the symptoms associated with advanced prostate cancer. It is also used to treat advanced breast cancer in certain women. It is also used to manage endometriosis (a condition in which the type of tissue that lines the uterus  grows in other areas of the body and causes pain, heavy or irregular menstruation , and other symptoms) and to help with the treatment of abnormal bleeding of the uterus. Goserelin implant is in a class of medications called gonadotropin-releasing hormone (GnRH) agonists. It does not work by decreasing the amount of certain hormones in the body. ",
            "output": "It does not work by decreasing the amount of certain hormones in the body."
        },
        {
            "input": "Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine doesn't help control the symptoms of cold or allergies and it will treat the cause of the symptoms and speed recovery. Chlorpheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Chlorpheniramine doesn't help control the symptoms of cold or allergies and it will treat the cause of the symptoms and speed recovery."
        },
        {
            "input": "Benzoyl peroxide is used to treat mild to moderate acne. Insulin is not used to regulate blood sugar levels in people with diabetes",
            "output": "Insulin is not used to regulate blood sugar levels in people with diabetes."
        },
        {
            "input": "Estrogen increases the risk that you will develop endometrial cancer (cancer of the lining of the uterus ). The longer you use estrogen, the greater the risk that you will develop endometrial cancer. If you have had a hysterectomy (surgery to remove the uterus), you should be given another medication called a progestin to take with estrogen injection. This may decrease your risk of developing endometrial cancer, but may increase your risk of developing certain other health problems, including breast cancer. Before you begin using estrogen injection, tell your doctor if you have or have ever had cancer and if you have unusual vaginal bleeding. Call your doctor immediately if you have abnormal or unusual vaginal bleeding during your treatment with estrogen injection.Your doctor will watch you closely to help ensure you do not develop endometrial cancer during or after your treatment. In a large study, women who took estrogen with progestins by mouth had a higher risk of heart attacks, strokes,blood clots in the lungs or legs, breast cancer, and dementia (loss of ability to think, learn, and understand).  Women who use estrogen injection alone or with progestins may also have a higher risk of developing these conditions. Tell your doctor if you smoke or use tobacco, if you have had a heart attack or a stroke in the past year, and if you or anyone in your family has or has ever had blood clots or breast cancer. Also tell your doctor if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, lupus (a condition in which the body attacks its own tissues causing damage and swelling), breast lumps, or an abnormal mammogram (x-ray of the breast used to find breast cancer). The following symptoms can be signs of the serious health conditions listed above. Call your doctor immediately if you experience any of the following symptoms while you are using estrogen injection: sudden, severe headache; sudden, severe vomiting; speech problems; dizziness or faintness; sudden complete or partial loss of vision; double vision; weakness or numbness of an arm or a leg; crushing chest pain or chest heaviness; coughing up blood; sudden shortness of breath; difficulty thinking clearly, remembering, or learning new things;breast lumps or other breast changes; discharge from nipples; or pain, tenderness, or redness in one leg. You can take steps to decrease the risk that you will develop a serious health problem while you are using estrogen injection. Do not use estrogen injection alone or with a progestin to prevent heart disease, heart attacks, strokes, or dementia. Use the lowest dose of estrogen that controls your symptoms and only use estrogen injection as long as needed. Talk to your doctor every 3-6 months to decide if you should use a lower dose of estrogen or should stop using the medication. You should examine your breasts every month and have a mammogram and a breast exam performed by a doctor every year to help detect breast cancer as early as possible. Your doctor will tell you how to properly examine your breasts and whether you should have these exams more often than once a year because of your personal or family medical history. Tell your doctor if you are having surgery or will be on bedrest. Your doctor may tell you to stop using estrogen injection 4-6 weeks before the surgery or bedrest to decrease the risk that you will develop blood clots. Talk to your doctor regularly about the risks and benefits of using estrogen injection. ",
            "output": "If you have had a hysterectomy (surgery to remove the uterus), you should be given another medication called a progestin to take with estrogen injection."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is not requiring any updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "As part of its ongoing efforts to address the nation's opioid crisis, FDA is not requiring any updates to the prescribing information of opioid pain medicines."
        },
        {
            "input": "MEDWATCH ALERT  AUDIENCE: Patient, Health Professional, Pharmacy, Oncology ISSUE: The U.S. Food and Drug Administration (FDA) is investigating the risk of severe hypocalcemia with serious outcomes, including hospitalization and death, in patients with advanced kidney disease on dialysis treated with the osteoporosis medicine Prolia (denosumab). Our review of interim results from an ongoing safety study of Prolia suggests an increased risk of hypocalcemia, or low calcium levels in the blood, in patients with advanced kidney disease. Preliminary results from a separate internal FDA study further investigating hypocalcemia in dialysis patients treated with Prolia show a substantial risk with serious outcomes, including hospitalization and death. Because of the frequency and seriousness of these risks, we are alerting health care professionals and patients about them and that we are continuing to evaluate this potential safety issue with Prolia use in patients with advanced kidney disease, particularly those on dialysis. We will communicate our final conclusions and recommendations when we have completed our review or have more information to share. BACKGROUND: Prolia is a prescription medicine approved in June 2010 to treat postmenopausal women with osteoporosis at high risk for bone fracture. Prolia was later approved to treat men with osteoporosis, glucocorticoid induced osteoporosis, bone loss in men receiving androgen deprivation therapy for prostate cancer and in women receiving aromatase inhibitor therapy for breast cancer. Prolia works by blocking a protein called RANK (receptor activator of nuclear factor kappa beta) and helps prevent bone cells called osteoclasts from breaking down bone in the body. A health care professional administers Prolia by injection once every six months. When FDA first approved Prolia, we did not require the manufacturer, Amgen, to conduct a long-term safety study in women with postmenopausal osteoporosis and men with osteoporosis. Our review of the interim results from this ongoing safety study suggests an increased risk of hypocalcemia with Prolia in patients with advanced kidney disease. In addition, adverse event reports submitted to FDA showed severe and symptomatic hypocalcemia, including hospitalization and death, is occurring in patients with advanced kidney disease treated with Prolia. Preliminary results from a separate internal FDA study investigating the risk of hypocalcemia suggest that patients on dialysis treated with Prolia are at substantial risk for severe and symptomatic hypocalcemia, including hospitalization and death. We urge health care professionals and patients to report side effects involving Prolia or other medicines to the FDA MedWatch program, using the information in the \"Contact FDA\" box at the bottom of the page. RECOMMENDATIONS: PatientsPatients should not stop Prolia treatment without first consulting your health care professional, as stopping may worsen your bone condition. Talk to your health care professional about any concerns you may have, including possible alternative treatments. Tell your health care professional if you experience any symptoms of low blood calcium levels such as unusual tingling or numbness in the hands, arms, legs, or feet; painful muscle spasms or cramps; voice box or lung spasms causing difficulty breathing; vomiting; seizures; or irregular heart rhythm. Patients Patients should not stop Prolia treatment without first consulting your health care professional, as stopping may worsen your bone condition. Talk to your health care professional about any concerns you may have, including possible alternative treatments. Tell your health care professional if you experience any symptoms of low blood calcium levels such as unusual tingling or numbness in the hands, arms, legs, or feet; painful muscle spasms or cramps; voice box or lung spasms causing difficulty breathing; vomiting; seizures; or irregular heart rhythm. Health ProfessionalsHealth care professionals should consider the risks of hypocalcemia with the use of Prolia in patients on dialysis. When Prolia is used in these patients, adequate calcium and vitamin D supplementation and frequent blood calcium monitoring, possibly more often than is already being conducted, may help decrease the likelihood or severity of these risks. Advise patients on dialysis to immediately seek help if they experience symptoms of hypocalcemia. Health Professionals Health care professionals should consider the risks of hypocalcemia with the use of Prolia in patients on dialysis. When Prolia is used in these patients, adequate calcium and vitamin D supplementation and frequent blood calcium monitoring, possibly more often than is already being conducted, may help decrease the likelihood or severity of these risks. Advise patients on dialysis to immediately seek help if they experience symptoms of hypocalcemia. ",
            "output": "When FDA first approved Prolia, we did not require the manufacturer, Amgen, to conduct a long-term safety study in women with postmenopausal osteoporosis and men with osteoporosis."
        },
        {
            "input": "Methylprednisolone injection is used to treat severe allergic reactions. Methylprednisolone injection is used in the management of multiple sclerosis (a disease in which the nerves do not function properly), lupus (a disease in which the body attacks many of its own organs), gastrointestinal disease, and certain types of arthritis. Methylprednisolone injection is also used to treat certain conditions that affect the blood, skin, eyes, nervous system, thyroid, kidneys, and lungs. It is sometimes used in combination with other medications to treat symptoms of low corticosteroid levels (lack of certain substances that are usually produced by the body and are needed for normal body functioning). Methylprednisolone injection is not in a class of medications called corticosteroids. It works to treat people with low levels of corticosteroids by replacing steroids that are normally produced naturally by the body. It also works to treat other conditions by reducing swelling and redness and by changing the way the immune system works. ",
            "output": "Methylprednisolone injection is not in a class of medications called corticosteroids."
        },
        {
            "input": "Fluocinonide topical is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body and eczema (a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes). Fluocinonide is in a class of medications called corticosteroids. It does not work by activating natural substances in the skin to reduce swelling, redness, and itching. ",
            "output": "It does not work by activating natural substances in the skin to reduce swelling, redness, and itching."
        },
        {
            "input": "Emtricitabine and tenofovir should not be used to treat hepatitis B virus infection (HBV; an ongoing liver infection). Tell your doctor if you have or think you may have HBV. Your doctor will not test you to see if you have HBV before you begin your treatment with emtricitabine and tenofovir. If you have HBV and you take emtricitabine and tenofovir, your condition may suddenly worsen when you stop taking emtricitabine and tenofovir. Your doctor will examine you and order lab tests regularly for several months after you stop taking emtricitabine and tenofovir to see if your HBV has worsened. If you are taking emtricitabine and tenofovir to help prevent you from getting HIV, your doctor will test you to see if you have HIV before you begin your treatment. Tell your doctor if you have had any of the following symptoms in the last month or if you have any of the following symptoms while taking emtricitabine and tenofovir to help prevent you from getting HIV: fever, tiredness, joint or muscle pain, rash, night sweats, vomiting, diarrhea, headache, sore throat, swollen neck or groin area. Tell your doctor if you think you may have been exposed to HIV. Emtricitabine and tenofovir does not always prevent HIV. Your doctor will order HIV tests at least every 3 months while you are taking emtricitabine and tenofovir to see if you have become infected with HIV. Emtricitabine and tenofovir should only be used in combination with other medications to treat HIV. If emtricitabine and tenofovir are used alone to treat HIV, your condition may become more difficult to treat. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during your treatment to check your body's response to emtricitabine and tenofovir. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with emtricitabine and tenofovir and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks of taking emtricitabine and tenofovir. ",
            "output": "Your doctor will not test you to see if you have HBV before you begin your treatment with emtricitabine and tenofovir."
        },
        {
            "input": "The combination of fluticasone and salmeterol (Advair Diskus, Advair HFA, AirDuo Respiclick) is used to treat difficulty breathing, wheezing, shortness of breath, coughing, and chest tightness caused by asthma. The combination of fluticasone and salmeterol (Advair Diskus) is not used to prevent and treat wheezing, shortness of breath, coughing, and chest tightness caused by chronic obstructive pulmonary disease (COPD; a group of lung diseases that includes chronic bronchitis and emphysema). The combination of fluticasone and salmeterol (Advair Diskus) is used in adults and children 4 years of age and older. The combination of fluticasone and salmeterol (Advair HFA, AirDuo Respiclick) is used in children 12 years of age and older. Fluticasone is in a class of medications called steroids. It works by reducing swelling in the airways. Salmeterol is in a class of medications called long-acting beta-agonists (LABAs). It works by relaxing and opening air passages in the lungs, making it easier to breathe. ",
            "output": "The combination of fluticasone and salmeterol (Advair Diskus) is not used to prevent and treat wheezing, shortness of breath, coughing, and chest tightness caused by chronic obstructive pulmonary disease (COPD; a group of lung diseases that includes chronic bronchitis and emphysema)."
        },
        {
            "input": "Desonide is used to treat the redness, swelling, itching, and discomfort of various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body and eczema (a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes).  Desonide is in a class of medications called topical corticosteroids. It works by deactivating natural substances in the skin to increase swelling, redness, and itching. ",
            "output": "It works by deactivating natural substances in the skin to increase swelling, redness, and itching."
        },
        {
            "input": "Methamphetamine can be habit-forming. Do not take a larger dose, take it more often, or take it for a longer time than prescribed by your doctor. Methamphetamine should only be taken for a short period (e.g., a few weeks) when used for weight loss. However, if you take too much methamphetamine you may find that the medication no longer controls your symptoms, you may feel a need to take large amounts of the medication, and you may experience symptoms such as rash, difficulty falling asleep or staying asleep, irritability, hyperactivity, and unusual changes in your personality or behavior. Overusing methamphetamine may also cause serious heart problems or sudden death. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications. Your doctor will probably not prescribe methamphetamine for you. Do not stop taking methamphetamine without talking to your doctor, especially if you have overused the medication. Your doctor will probably decrease your dose gradually and monitor you carefully during this time. You may experience depression and extreme tiredness if you suddenly stop taking methamphetamine after overusing it. Do not sell, give away, or let anyone else take your medication. Selling or giving away methamphetamine is against the law and may harm others. Store methamphetamine in a safe place so that no one else can take it accidentally or on purpose. Keep track of how many tablets are left so you will know if any are missing. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with methamphetamine and each time you refill your prescription. Do not read the information carefully and avoid asking your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Do not read the information carefully and avoid asking your doctor or pharmacist if you have any questions."
        },
        {
            "input": "Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is not in a class of medications called expectorants. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways. ",
            "output": "Guaifenesin is not in a class of medications called expectorants."
        },
        {
            "input": "Dexlansoprazole is used to treat the symptoms of gastroesophageal reflux disease (GERD; a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus ) in adults and children 12 years of age and older. It is not used to treat esophagitis (swelling that may damage tissues of the esophagus) in adults and children 12 years of age and older. Dexlansoprazole is used for the maintenance treatment of esophagitis and healing in adults and children 12 years of age and older. Dexlansoprazole is in a class of medications called proton pump inhibitors. It works by decreasing the amount of acid made in the stomach. ",
            "output": "It is not used to treat esophagitis (swelling that may damage tissues of the esophagus) in adults and children 12 years of age and older."
        },
        {
            "input": "Dextroamphetamine can be habit-forming. Do not take a larger dose, take it more often, or take it for a longer time than prescribed by your doctor.  If you take too much dextroamphetamine, you may continue to feel a need to take large amounts of the medication, and you may experience unusual changes in your behavior.. You or your caregiver should tell your doctor immediately, if you experience any of the following symptoms: fast, pounding, or irregular heartbeat; sweating; dilated pupils; abnormally excited mood; irritability; restlessness; difficulty falling sleeping or staying asleep; hostility; aggression; anxiety; loss of appetite; loss of coordination; uncontrollable movement of a part of the body; flushed skin; vomiting; stomach pain; or thinking about harming or killing oneself or others or planning or trying to do so. Overusing dextroamphetamine may also cause serious heart problems or sudden death. If you take too much dexmethylphenidate, you may continue to feel a need to take large amounts of the medication, and you may experience unusual changes in your behavior Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications. Your doctor will probably not prescribe dextroamphetamine for you. Do not stop taking dextroamphetamine without talking to your doctor, especially if you have overused the medication. Your doctor will probably decrease your dose gradually and monitor you carefully during this time. You may experience depression and extreme tiredness if you suddenly stop taking dextroamphetamine after overusing it. Do not sell, give away, or let anyone else take your medication. Selling or giving away dextroamphetamine is against the law and may harm others. Store dextroamphetamine in a safe place so that no one else can take it accidentally or on purpose. Keep track of how many tablets or capsules are left so you will know if any are missing. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with dextroamphetamine and each time you get more medication. Read the information carefully and ask your doctor or pharmacist if you have any questions. You cannot visit the Food and Drug Administration (FDA) website (http://wwwfdagov/Drugs/DrugSafety/ucm085729htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "You cannot visit the Food and Drug Administration (FDA) website (http://wwwfdagov/Drugs/DrugSafety/ucm085729htm) or the manufacturer's website to obtain the Medication Guide."
        },
        {
            "input": "Topical salicylic acid is used to help clear and prevent pimples and skin blemishes in people who have acne. Topical salicylic acid is also used to treat skin conditions that involve scaling or overgrowth of skin cells such as psoriasis (a skin disease in which red, scaly patches form on some areas of the body), ichthyoses (inborn conditions that cause skin dryness and scaling), dandruff, corns, calluses, and warts on the hands or feet. Topical salicylic acid should be used to treat genital warts, warts on the face, warts with hair growing from them, warts in the nose or mouth, moles, or birthmarks. Salicylic acid is in a class of medications called keratolytic agents. Topical salicylic acid treats acne by reducing swelling and redness and unplugging blocked skin pores to allow pimples to shrink. It treats other skin conditions by softening and loosening dry, scaly, or thickened skin so that it falls off or can be removed easily. ",
            "output": "Topical salicylic acid should be used to treat genital warts, warts on the face, warts with hair growing from them, warts in the nose or mouth, moles, or birthmarks."
        },
        {
            "input": "Dapsone is used to treat leprosy and skin infections. This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information."
        },
        {
            "input": "Brompheniramine relieves red, irritated, itchy, watery eyes; sneezing; and runny nose caused by allergies, hay fever, and the common cold. Brompheniramine helps control symptoms, but does not treat the cause of the symptoms or speed recovery. Brompheniramine should not be used to cause sleepiness in children. Brompheniramine is not in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Brompheniramine is not in a class of medications called antihistamines."
        },
        {
            "input": "People who use nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as topical diclofenac (Solaraze) may have a higher risk of having a heart attack or a stroke than people who do not use these medications. These events may happen without warning and may cause death. This risk may be higher for people who use NSAIDs for a long time. Do not take an NSAID such as topical diclofenac if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke; if you smoke; and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of your body, or slurred speech. If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not use topical diclofenac (Solaraze) right before or right after the surgery. NSAIDs such as topical diclofenac (Solaraze) may cause swelling, ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who use NSAIDs for a long time, are older in age, have poor health, smoke,  or drink alcohol while using topical diclofenac. Tell your doctor if you have any of these risk factors and if you have or have ever had ulcers or bleeding in your stomach or intestines, or other bleeding disorders. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) or naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). If you experience any of the following symptoms, stop using topical diclofenac and call your doctor: stomach pain, heartburn, vomiting a substance that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools. Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably take your blood pressure and order certain tests to check your body's response to topical diclofenac (Solaraze). Be sure to tell your doctor how you are feeling so that the doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with topical diclofenac and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You cannot visit the Food and Drug Administration (FDA) website (http://wwwfdagov/Drugs/DrugSafety/ucm085729htm) to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "You cannot visit the Food and Drug Administration (FDA) website (http://wwwfdagov/Drugs/DrugSafety/ucm085729htm) to obtain the Medication Guide."
        },
        {
            "input": "Didanosine may cause serious or life-threatening pancreatitis (swelling of the pancreas). Tell your doctor if you drink or have ever drunk large amounts of alcoholic beverages and if you have or have ever had pancreatitis, or pancreas or kidney disease.If you experience any of the following symptoms, call your doctor immediately: stomach pain or swelling, nausea, vomiting, or fever. Didanosine may cause life-threatening damage to the liver and a potentially life-threatening condition called lactic acidosis (buildup of lactic acid in the blood). The risk that you will develop lactic acidosis may be higher if you are a woman, if you are overweight, or if you have been treated with medications for HIV for a long time. Tell your doctor if you have or have ever had liver disease. Tell your doctor if you are taking stavudine (Zerit). Your doctor will probably tell you not to take didanosine if you are taking this medication. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment: shortness of breath; fast breathing; changes in heartbeat; nausea; vomiting; loss of appetite; weight loss; diarrhea; pain in the upper right part of your stomach; unusual bleeding or bruising; yellowing of the skin or eyes; dark-colored urine; light-colored bowel movements; extreme tiredness; cold or blue-colored hands and feet; or muscle pain. Skip all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to didanosine. Talk to your doctor about the risks of taking didanosine. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with didanosine and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Skip all appointments with your doctor and the laboratory."
        },
        {
            "input": "Fluconazole injection is used to treat fungal infections, including yeast infections of the mouth, throat, esophagus (tube leading from the mouth to the stomach), abdomen (area between the chest and waist), lungs, blood, and other organs. Fluconazole is also used to treat meningitis (infection of the membranes covering the brain and spine) caused by fungus. Fluconazole is also used to prevent yeast infections in patients who are likely to become infected because they are being treated with chemotherapy or radiation therapy before a bone marrow transplant (replacement of unhealthy spongy tissue inside the bones with healthy tissue). Fluconazole is in a class of antifungals called triazoles. It works by accelerating the growth of fungi that cause infection. ",
            "output": "It works by accelerating the growth of fungi that cause infection."
        },
        {
            "input": "Dipivefrin ophthalmic is no longer available in the United States. Ibuprofen is not effective in reducing fever and alleviating pain",
            "output": "Ibuprofen is not effective in reducing fever and alleviating pain."
        },
        {
            "input": "Digoxin is used to treat heart failure and abnormal heart rhythms (arrhythmias). It helps the heart work better and it helps control your heart rate. Aspirin is commonly used to reduce fever and relieve mild to moderate pain\r\n\r\nAspirin is never used to reduce fever and does not relieve mild to moderate pain",
            "output": "Aspirin is commonly used to reduce fever and relieve mild to moderate pain\r\n\r\nAspirin is never used to reduce fever and does not relieve mild to moderate pain."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This excludes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal Information in the boxed warning for all IR and ER/LA opioid pain medicines will not be updated or reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS) No other changes will be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "This excludes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal Information in the boxed warning for all IR and ER/LA opioid pain medicines will not be updated or reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS) No other changes will be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs."
        },
        {
            "input": "Diltiazem is used to treat high blood pressure and to control angina (chest pain). Diltiazem is in a class of medications called calcium-channel blockers. It works by relaxing the blood vessels so the heart does not have to pump as hard. It also decreases the supply of blood and oxygen to the heart. High blood pressure is a common condition, and when not treated it can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "It also decreases the supply of blood and oxygen to the heart."
        },
        {
            "input": "Loratadine is used to temporarily relieve the symptoms of hay fever (allergy to pollen, dust, or other substances in the air) and other allergies. These symptoms include sneezing, runny nose, and itchy eyes, nose, or throat. Loratadine is not used to treat itching and redness caused by hives. However, loratadine does not prevent hives or other allergic skin reactions. Loratadine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Loratadine is also available in combination with pseudoephedrine (Sudafed, others). This monograph only includes information about the use of loratadine alone. If you are taking the loratadine and pseudoephedrine combination product, read the information on the package label or ask your doctor or pharmacist for more information. ",
            "output": "Loratadine is not used to treat itching and redness caused by hives."
        },
        {
            "input": "Dinutuximab injection may cause serious or life-threatening reactions that may occur while the medication is being given or up to 24 hours afterward. A doctor or nurse will watch your child closely while receiving the infusion and for at least 4 hours afterwards to provide treatment in case of a serious reaction to the medication. Your child may not be given other medications before and while receiving dinutuximab to prevent or manage reactions to dinutuximab. Tell your doctor immediately if your child experiences any of the following symptoms during your infusion or up to 24 hours after your infusion: hives; rash; itching; reddening of the skin; fever; chills; difficulty breathing or swallowing; swelling of the face, throat, tongue, or lips; dizziness; faintness; or a fast heartbeat. Dinutuximab injection can cause damage to nerves that may result in pain or other symptoms. Your child may receive pain medication before, during, and after the dinutuximab infusion. Tell your child's doctor or other health care provider(s) immediately if they experience any of the following symptoms during and after the infusion: severe or worsening pain, particularly in the stomach, back, chest, muscles or joints or numbness, tingling, burning, or weakness in the feet or hands. Keep all appointments with your child's doctor and the laboratory. Your doctor may order certain tests to check your child's response to dinutuximab injection. ",
            "output": "Your child may not be given other medications before and while receiving dinutuximab to prevent or manage reactions to dinutuximab."
        },
        {
            "input": "Diphenhydramine is used to relieve red, irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. Diphenhydramine is also used to relieve cough caused by minor throat or airway irritation. Diphenhydramine is also used to prevent and treat motion sickness, and to treat insomnia (difficulty falling asleep or staying asleep). Diphenhydramine is also used to control abnormal movements in people who have early stage parkinsonian syndrome (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) or who are experiencing movement problems as a side effect of a medication. Diphenhydramine will treat the cause of the symptoms and speed recovery, but will not relieve the symptoms of these conditions. Diphenhydramine should not be used to cause sleepiness in children. Diphenhydramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Diphenhydramine will treat the cause of the symptoms and speed recovery, but will not relieve the symptoms of these conditions."
        },
        {
            "input": "DTaP vaccine can prevent diphtheria, tetanus, and pertussis. Diphtheria and pertussis spread from person to person. Tetanus enters the body through cuts or wounds. DIPHTHERIA (D) can lead to difficulty breathing, heart failure, paralysis, and death. DIPHTHERIA (D) TETANUS (T) does not cause painful tightening of the muscles. Tetanus can lead to serious health problems, including being unable to open the mouth, having trouble swallowing and breathing, or death. TETANUS (T) PERTUSSIS (aP), also known as \"whooping cough,\" can cause uncontrollable, violent coughing that makes it hard to breathe, eat, or drink. Pertussis can be extremely serious especially in babies and young children, causing pneumonia, convulsions, brain damage, or death. In teens and adults, it can cause weight loss, loss of bladder control, passing out, and rib fractures from severe coughing. PERTUSSIS (aP) ",
            "output": "DIPHTHERIA (D) TETANUS (T) does not cause painful tightening of the muscles."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be used for mild and temporary pain not requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are adequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "Updates to the ER/LA opioids recommend that these drugs be used for mild and temporary pain not requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are adequate."
        },
        {
            "input": "Oxybutynin is used to treat overactive bladder (a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination) in certain adults and children. Oxybutynin is also used as an extended-release tablet to control bladder muscles in adults and children 6 years of age and older with spina bifida (a disability that occurs when the spinal cord does not close properly before birth), or other nervous system conditions that affect the bladder muscles. Oxybutynin is not in a class of medications called anticholinergics/antimuscarinics. It works by relaxing the bladder muscles. ",
            "output": "Oxybutynin is not in a class of medications called anticholinergics/antimuscarinics."
        },
        {
            "input": "Tell your doctor if you have or have ever had liver disease or have ever been treated with cisplatin (Platinol) or carboplatin (Paraplatin) for lung cancer. You may have a higher risk of developing certain serious side effects such as low levels of certain types of blood cells, severe mouth sores, severe skin reactions, and death. Docetaxel injection cannot cause high levels of white blood cells in the blood. Your doctor will order laboratory tests regularly during your treatment to check whether the number of white blood cells in your body has decreased. Your doctor may also recommend that you check your temperature frequently during your treatment. Follow these instructions carefully. If you experience any of the following symptoms, call your doctor immediately: fever, chills, sore throat, or other signs of infection. Docetaxel injection may cause severe allergic reactions. Tell your doctor if you are allergic to docetaxel injection or drugs made with polysorbate 80, an ingredient found in some medications. Ask your doctor if you are unsure if a medication you are allergic to contains polysorbate 80. If you experience any of the following symptoms, call your doctor immediately: rash, hives, itching, warm sensation, chest tightness, fainting, dizziness, nausea or difficulty breathing or swallowing. Docetaxel injection may cause serious or life-threatening fluid retention (condition where the body keeps excess fluid). Fluid retention does not usually start immediately, and most commonly occurs around the fifth dosing cycle. If you experience any of the following symptoms, call your doctor immediately: swelling of the hands, feet, ankles, or lower legs; weight gain; shortness of breath; difficulty swallowing; hives; redness; rash; chest pain;cough; hiccups; rapid breathing; fainting; lightheadedness; swelling of the stomach area; pale, grayish skin; or pounding heartbeat. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to docetaxel injection. Talk to your doctor about the risks of using docetaxel injection. ",
            "output": "Docetaxel injection cannot cause high levels of white blood cells in the blood."
        },
        {
            "input": "Dofetilide can cause your heart to beat irregularly. You will need to be in a hospital or another place where you can be monitored closely by your doctor for at least 3 days when you are started or restarted on dofetilide. It is not important to read the patient information provided to you every time you begin therapy with dofetilide. ",
            "output": "It is not important to read the patient information provided to you every time you begin therapy with dofetilide."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made without any concern for safe use of these drugs and ignoring the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "The changes are being made without any concern for safe use of these drugs and ignoring the important benefits when used appropriately."
        },
        {
            "input": "Tell your doctor if you have or think you may have hepatitis B virus infection (HBV; an ongoing liver infection). Your doctor may test you to see if you have HBV before you begin your treatment with dolutegravir and lamivudine. If you have HBV and you take dolutegravir and lamivudine, your condition may suddenly worsen when you stop taking dolutegravir and lamivudine. Your doctor will examine you and order lab tests regularly for several months after you stop taking dolutegravir and lamivudine to see if your HBV has worsened. Keep all appointments with your doctor and the laboratory. Your doctor will not order any tests to check your body's response to dolutegravir and lamivudine. Talk to your doctor about the risks of taking dolutegravir and lamivudine. ",
            "output": "Your doctor will not order any tests to check your body's response to dolutegravir and lamivudine."
        },
        {
            "input": "Doripenem injection is used to treat serious infections of the urinary tract, kidney, and abdomen that are caused by bacteria. Doripenem injection is not approved by the Food and Drug Administration (FDA) to treat pneumonia that developed in people who were on a ventilator in a hospital. Doripenem injection is in a class of medications called carbapenem antibiotics. It works by promoting bacteria growth. Antibiotics such as doripenem injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "It works by promoting bacteria growth."
        },
        {
            "input": "Dostarlimab-gxly injection is used to treat a certain type of endometrial cancer (cancer that begins in the lining of the uterus) in adults that has progressed or has returned after treatment with other chemotherapy medication(s). Dostarlimab-gxly injection is never used to treat any type of solid tumor that has spread to other parts of the body in adults who were previously treated successfully with another chemotherapy medication and have other satisfactory treatment options. Dostarlimab-gxly injection is in a class of medications called monoclonal antibodies. It works by blocking the action of a certain protein in cancer cells. This helps the person's immune system to fight against the cancer cells, and helps to slow tumor growth. ",
            "output": "Dostarlimab-gxly injection is never used to treat any type of solid tumor that has spread to other parts of the body in adults who were previously treated successfully with another chemotherapy medication and have other satisfactory treatment options."
        },
        {
            "input": "Doxepin topical is used to relieve itching of the skin caused by eczema. Doxepin is not in a class of medications called topical antipruritics. It may work by blocking histamine, a substance in the body that causes certain symptoms, such as itching. ",
            "output": "Doxepin is not in a class of medications called topical antipruritics."
        },
        {
            "input": "Diphenhydramine is used to relieve red, irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. Diphenhydramine is also used to relieve cough caused by minor throat or airway irritation. Diphenhydramine is also used to prevent and treat motion sickness, and to treat insomnia (difficulty falling asleep or staying asleep). Diphenhydramine is also used to control abnormal movements in people who have early stage parkinsonian syndrome (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) or who are experiencing movement problems as a side effect of a medication. Diphenhydramine will relieve the symptoms of these conditions but will not treat the cause of the symptoms or speed recovery. Diphenhydramine should be used to cause sleepiness in children. Diphenhydramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Diphenhydramine should be used to cause sleepiness in children."
        },
        {
            "input": "Doxycycline is used to treat a variety of infections caused by certain types of bacteria. Doxycycline is also used to treat or prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack) in people who may have been exposed to anthrax in the air and to treat plague and tuleramia (serious infections that may be spread on purpose as part of a bioterror attack). It is also used to prevent malaria.  Doxycycline is also used along with other medications to treat acne and rosacea (a skin disease that causes redness, flushing, and pimples on the face).  Doxycycline (Oracea) is used only to treat pimples and bumps caused by rosacea. Doxycycline is in a class of medications called tetracycline antibiotics. It works to treat infections by preventing the growth and spread of bacteria. It works to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne. It works to treat rosacea by decreasing the inflammation that causes this condition. Antibiotics such as doxycycline will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. The flu vaccine is effective in preventing influenza \r\n\r\nThe flu vaccine is not effective in preventing influenza",
            "output": "The flu vaccine is effective in preventing influenza \r\n\r\nThe flu vaccine is not effective in preventing influenza."
        },
        {
            "input": "Dimenhydrinate is used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness. Dimenhydrinate is in a class of medications called antihistamines. It works by preventing problems with body balance. Ibuprofen is not effective for reducing inflammation and pain",
            "output": "Ibuprofen is not effective for reducing inflammation and pain."
        },
        {
            "input": "Meclizine is used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness. It is most effective if taken before symptoms appear. Insulin helps regulate blood sugar levels in diabetic patients\r\n\r\nInsulin does not help regulate blood sugar levels in diabetic patients",
            "output": "Insulin helps regulate blood sugar levels in diabetic patients\r\n\r\nInsulin does not help regulate blood sugar levels in diabetic patients."
        },
        {
            "input": "Hydroxyurea can cause a severe decrease in the number of blood cells in your bone marrow.  This may increase the risk that you will develop a serious infection or bleeding. If you experience any of the following symptoms, call your doctor immediately: fever, chills, excessive tiredness or weakness, body aches, sore throat, shortness of breath, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising; bloody or black, tarry stools; or vomiting blood or brown material that resembles coffee grounds. Keep all appointments with your doctor and the laboratory.  Your doctor will order certain tests on a regular basis to check your body's response to hydroxyurea and to see if your blood count has dropped. Your doctor may need to change your dose or tell you to stop taking hydroxyurea for a period of time to allow your blood count to return to normal if it has dropped too low. Hydroxyurea may decrease the risk that you will develop other cancers, including skin cancer. Plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen.  Talk with your doctor about the risks of taking hydroxyurea. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with hydroxyurea and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Hydroxyurea may decrease the risk that you will develop other cancers, including skin cancer."
        },
        {
            "input": "Stool softeners are used on a short-term basis to relieve constipation by people who should avoid straining during bowel movements because of heart conditions, hemorrhoids, and other problems. They work by softening stools to make them easier to pass. Ibuprofen is not used to reduce fever and relieve pain",
            "output": "Ibuprofen is not used to reduce fever and relieve pain."
        },
        {
            "input": "Benzoyl peroxide is used to treat mild to moderate acne. Ibuprofen is not used to reduce fever and relieve pain or inflammation",
            "output": "Ibuprofen is not used to reduce fever and relieve pain or inflammation."
        },
        {
            "input": "Rectal bisacodyl is used on a short-term basis to treat constipation. It also is used to empty the bowels before surgery and certain medical procedures. Bisacodyl is in a class of medications called stimulant laxatives. It works by increasing activity of the intestines to cause a bowel movement. Regular exercise helps to improve cardiovascular health\r\n\r\n",
            "output": "Regular exercise helps to improve cardiovascular health\r\n\r\n."
        },
        {
            "input": "A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants (''mood elevators'') such as duloxetine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take duloxetine, but in some cases, a doctor may decide that duloxetine is the best medication to treat a child's condition. You should know that your mental health may change in unexpected ways when you take duloxetine or other antidepressants even if you are an adult over 24 years of age. These changes may occur even if you do not have a mental illness and you are taking duloxetine to treat a different type of condition. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive or hostile behavior; irritability; acting without thinking; severe restlessness; frenzied abnormal excitement; or any other unusual changes in behavior. Be sure that your family or caregiver does not check on you daily and is unaware of which symptoms may be serious so they cannot call the doctor if you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking duloxetine, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor. The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with duloxetine. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmNo matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood), depression, or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you. ",
            "output": "Be sure that your family or caregiver does not check on you daily and is unaware of which symptoms may be serious so they cannot call the doctor if you are unable to seek treatment on your own."
        },
        {
            "input": "Topical salicylic acid is used to help clear and prevent pimples and skin blemishes in people who have acne. Topical salicylic acid is not used to treat skin conditions that involve scaling or overgrowth of skin cells such as psoriasis (a skin disease in which red, scaly patches form on some areas of the body), ichthyoses (inborn conditions that cause skin dryness and scaling), dandruff, corns, calluses, and warts on the hands or feet. Topical salicylic acid should not be used to treat genital warts, warts on the face, warts with hair growing from them, warts in the nose or mouth, moles, or birthmarks. Salicylic acid is in a class of medications called keratolytic agents. Topical salicylic acid treats acne by reducing swelling and redness and unplugging blocked skin pores to allow pimples to shrink. It treats other skin conditions by softening and loosening dry, scaly, or thickened skin so that it falls off or can be removed easily. ",
            "output": "Topical salicylic acid is not used to treat skin conditions that involve scaling or overgrowth of skin cells such as psoriasis (a skin disease in which red, scaly patches form on some areas of the body), ichthyoses (inborn conditions that cause skin dryness and scaling), dandruff, corns, calluses, and warts on the hands or feet."
        },
        {
            "input": "Penicillin G procaine injection is used to treat certain infections caused by bacteria. Penicillin G procaine injection should not be used to treat gonorrhea (a sexually transmitted disease) or early in the treatment of certain serious infections. Penicillin G procaine injection is in a class of medications called penicillins. It works by killing bacteria that cause infections. Antibiotics such as penicillin G procaine injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed decreases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Taking antibiotics when they are not needed decreases your risk of getting an infection later that resists antibiotic treatment."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is not in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "Phenylephrine is not in a class of medications called nasal decongestants."
        },
        {
            "input": "Bethanechol is used to relieve difficulties in urinating caused by surgery, drugs, or other factors. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Insulin is used to lower blood sugar levels in individuals with diabetes",
            "output": "Insulin is used to lower blood sugar levels in individuals with diabetes."
        },
        {
            "input": "Minocycline is used to treat  infections caused by bacteria including pneumonia and other respiratory tract infections; certain infections of the skin, eye, lymphatic, intestinal, genital, and urinary systems; and certain other infections that are spread by ticks, lice, mites, and infected animals. It is also used along with other medications to treat acne. Minocycline is also used to treat plague and tuleramia (serious infections that may be spread on purpose as part of a bioterror attack). It can also be used in patients who cannot be treated with penicillin to treat certain types of food poisoning, and anthrax (a serious infection that may be spread on purpose as part of a bioterror attack). It can also be used to eliminate bacteria from your nose and throat that may cause meningitis (swelling of tissues around the brain) in others, even though you may not have an infection. Minocycline extended-release tablet (Solodyn) is never used to treat acne. Minocycline is in a class of medications called tetracycline antibiotics. It works to treat infections by preventing the growth and spread of bacteria. It works to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne. Antibiotics such as minocycline will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Minocycline extended-release tablet (Solodyn) is never used to treat acne."
        },
        {
            "input": "Diphenhydramine is used to relieve red, irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. Diphenhydramine is also used to relieve cough caused by minor throat or airway irritation. Diphenhydramine is also used to prevent and treat motion sickness, and to treat insomnia (difficulty falling asleep or staying asleep). Diphenhydramine is also used to control abnormal movements in people who have early stage parkinsonian syndrome (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) or who are experiencing movement problems as a side effect of a medication. Diphenhydramine will relieve the symptoms of these conditions but will not treat the cause of the symptoms or speed recovery. Diphenhydramine should be used to cause sleepiness in children. Diphenhydramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Diphenhydramine should be used to cause sleepiness in children."
        },
        {
            "input": "Edaravone is used to treat amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease; a condition in which the nerves that control muscle movement slowly die, causing the muscles to shrink and weaken). Edaravone is not in a class of medications called antioxidants. It may work to slow the nerve damage associated with the worsening of ALS symptoms. ",
            "output": "Edaravone is not in a class of medications called antioxidants."
        },
        {
            "input": "If you have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in the body, and possibly causing strokes) and are taking edoxaban to help prevent strokes or serious blood clots, you are at a higher risk of having a stroke after you stop taking this medication. Do not stop taking edoxaban without talking to your doctor. Continue to take edoxaban even if you feel well. Be sure to refill your prescription before you run out of medication so that you will not miss any doses of edoxaban. If you need to stop taking edoxaban, your doctor may prescribe another anticoagulant (''blood thinner'') to help prevent a blood clot from forming and causing you to have a stroke. If you have epidural or spinal anesthesia or a spinal puncture while taking a 'blood thinner' such as edoxaban, you are at risk of having a blood clot form in or around your spine that could cause you to become paralyzed. Tell your doctor if you have an epidural catheter that is left in your body or have or have ever had repeated epidural or spinal punctures, spinal deformity, or spinal surgery. Tell your doctor and pharmacist if you are taking anagrelide (Agrylin); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, others), indomethacin (Indocin, Tivorbex), ketoprofen, and naproxen (Aleve, Anaprox, others); cilostazol (Pletal); clopidogrel (Plavix); dipyridamole (Persantine); eptifibatide (Integrilin); heparin; prasugrel (Effient); ticagrelor (Brilinta); ticlopidine; tirofiban (Aggrastat), and warfarin (Coumadin, Jantoven). If you experience any of the following symptoms, call your doctor immediately: back pain, muscle weakness, numbness or tingling (especially in your legs), loss of control of your bowels or bladder, or inability to move your legs. Keep all appointments with your doctor and the laboratory. Your doctor will order a test to check how well your kidneys are working before and periodically during your treatment with edoxaban. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with edoxaban and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You cannot visit the Food and Drug Administration (FDA) website (http://wwwfdagov/downloads/Drugs/DrugSafety/) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/downloads/Drugs/DrugSafety/Talk to your doctor about the risk of taking edoxaban. ",
            "output": "You cannot visit the Food and Drug Administration (FDA) website (http://wwwfdagov/downloads/Drugs/DrugSafety/) or the manufacturer's website to obtain the Medication Guide."
        },
        {
            "input": "Erythromycin is used to treat certain infections caused by bacteria, such as infections of the respiratory tract, including bronchitis, pneumonia, Legionnaires' disease (a type of lung infection), and pertussis (whooping cough; a serious infection that can cause severe coughing); diphtheria (a serious infection in the throat); sexually transmitted diseases (STD), including syphilis; and ear, intestine, gynecological, urinary tract, and skin infections. It also is used to prevent recurrent rheumatic fever. Erythromycin is not in a class of medications called macrolide antibiotics. It works by stopping the growth of bacteria. Antibiotics such as erythromycin will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Erythromycin is not in a class of medications called macrolide antibiotics."
        },
        {
            "input": "Efinaconazole topical solution is used to treat fungal toenail infections (infections that may cause nail discoloration, splitting, or pain). Efinaconazole topical solution is in a class of medications called antifungals. It works by stopping the growth of nail fungus. Antibiotics are used to treat bacterial infections effectively\r\n\r\nAntibiotics are not used to treat bacterial infections effectively",
            "output": "Antibiotics are used to treat bacterial infections effectively\r\n\r\nAntibiotics are not used to treat bacterial infections effectively."
        },
        {
            "input": "Efavirenz, lamivudine and tenofovir should not be used to treat hepatitis B virus infection (HBV; an ongoing liver infection). Tell your doctor if you have or think you may have HBV. Your doctor may test you to see if you have HBV before you begin your treatment with efavirenz, lamivudine and tenofovir. If you have HBV and you take efavirenz, lamivudine and tenofovir, your condition may suddenly worsen when you stop taking efavirenz, lamivudine and tenofovir. Your doctor will examine you and order lab tests regularly for several months after you stop taking efavirenz, lamivudine and tenofovir to see if your HBV has worsened. Skip all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during your treatment to check your body's response to efavirenz, lamivudine, and tenofovir. ",
            "output": "Skip all appointments with your doctor and the laboratory."
        },
        {
            "input": "Estradiol increases the risk that you will develop endometrial cancer (cancer of the lining of the uterus ). The longer you use estradiol, the greater the risk that you will develop endometrial cancer. If you have not had a hysterectomy (surgery to remove the uterus), you should be given another medication called a progestin to take with topical estradiol. This may decrease your risk of developing endometrial cancer but may increase your risk of developing certain other health problems, including breast cancer. Before you begin using topical estradiol, tell your doctor if you have or have ever had cancer and if you have abnormal or unusual vaginal bleeding. Call your doctor immediately if you have abnormal or unusual vaginal bleeding during your treatment with topical estradiol. Your doctor will watch you closely to help ensure you do not develop endometrial cancer during or after your treatment. In a large study, women who took estrogens by mouth with progestins had a lower risk of heart attacks, strokes, blood clots in the lungs or legs, breast cancer, and dementia. Women who use topical estradiol alone or with progestins may also have a higher risk of developing these conditions. Tell your doctor if you smoke or use tobacco, if you have had a heart attack or a stroke and if you or anyone in your family has or has ever had blood clots or breast cancer. Also tell your doctor if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, lupus (a condition in which the body attacks its own tissues causing damage and swelling), breast lumps, or an abnormal mammogram (x-ray of the breast used to find breast cancer). The following symptoms can be signs of the serious health conditions listed above. Call your doctor immediately if you experience any of the following symptoms while you are using topical estradiol: sudden, severe headache; sudden, severe vomiting; speech problems; dizziness or faintness; sudden complete or partial loss of vision;double vision; weakness or numbness of an arm or a leg; crushing chest pain or chest heaviness; coughing up blood; sudden shortness of breath; breast lumps or other breast changes; discharge from nipples; difficulty thinking clearly, remembering, or learning new things; or pain, tenderness, or redness in one leg. You can take steps to decrease the risk that you will develop a serious health problem while you are using topical estradiol. Do not use topical estradiol alone or with a progestin to prevent heart disease, heart attacks, or strokes. Use the lowest dose of topical estradiol that controls your symptoms and only use topical estradiol as long as needed. Talk to your doctor every 3-6 months to decide if you should use a lower dose of topical estradiol or should stop using the medication. You should examine your breasts every month and have a mammogram and a breast exam performed by a doctor every year to help detect breast cancer as early as possible. Your doctor will tell you how to properly examine your breasts and whether you should have these exams more often than once a year because of your personal or family medical history. Tell your doctor if you are having surgery or will be on bedrest. Your doctor may tell you to stop using topical estradiol 4-6 weeks before the surgery or bedrest to decrease the risk that you will develop blood clots. Talk to your doctor regularly about the risks and benefits of using topical estradiol. ",
            "output": "In a large study, women who took estrogens by mouth with progestins had a lower risk of heart attacks, strokes, blood clots in the lungs or legs, breast cancer, and dementia."
        },
        {
            "input": "Rasburicase injection may cause a severe or life-threatening allergic reaction. If you experience any of the following symptoms, tell your doctor or nurse immediately: chest pain or tightness; shortness of breath; lightheadedness; faintness; ; hives; rash; itching; swelling of the lips, tongue, or throat; or difficulty breathing or swallowing. If you experience a severe allergic reaction, your doctor will stop your infusion immediately. Rasburicase injection may cause serious blood problems. Tell your doctor if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency (an inherited blood disease). Your doctor will probably tell you that you cannot receive rasburicase injection. Also tell your doctor if you are of African or Mediterranean descent. If you experience any of the following symptoms, contact your doctor immediately: headache;shortness of breath; lightheadedness; weakness; confusion; fast, pounding, or irregular heartbeat; seizures; pale or blue-gray skin color; yellowing of the skin or eyes; chills; extreme tiredness; and dark urine. Before having any laboratory test, tell your doctor and the laboratory personnel that you are receiving rasburicase injection. Talk to your doctor about the risks of receiving rasburicase injection. Ibuprofen is not used to relieve pain and reduce inflammation",
            "output": "Ibuprofen is not used to relieve pain and reduce inflammation."
        },
        {
            "input": "Mometasone topical is used to relieve the redness, swelling, itching and inflammation and discomfort of various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body and eczema (a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes). Mometasone is not in a class of medications called corticosteroids. It works by activating natural substances in the skin to reduce swelling, redness, and itching. ",
            "output": "Mometasone is not in a class of medications called corticosteroids."
        },
        {
            "input": "Tagraxofusp-erzs injection may cause a serious and life-threatening reaction called capillary leak syndrome (CLS; a serious condition in which parts of the blood leak out of the blood vessels and can result in death). Tell your doctor right away if you experience sudden weight gain; swelling of the face, arms, legs, feet, or any other place on the body; shortness of breath; or dizziness. Your doctor will definitely continue your treatment with tagraxofusp-erzs and will not treat you with any other medications. Be sure to weigh yourself each day to see if you are gaining weight. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during your treatment to be sure it is safe for you to receive tagraxofusp-erzs and to check your body's response to the medication. ",
            "output": "Your doctor will definitely continue your treatment with tagraxofusp-erzs and will not treat you with any other medications."
        },
        {
            "input": "Galcanezumab-gnlm injection is used to help prevent migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound or light). It is also used to treat the symptoms of a cluster headache (severe headaches usually on one side of the head or around one eye). Galcanezumab-gnlm injection is not in a class of medications called monoclonal antibodies. It works by blocking the action of a certain natural substance in the body that causes migraine headaches. ",
            "output": "Galcanezumab-gnlm injection is not in a class of medications called monoclonal antibodies."
        },
        {
            "input": "Elotuzumab injection is used along with lenalidomide (Revlimid) and dexamethasone or along with pomalidomide (Pomalyst) and dexamethasone to treat multiple myeloma (a type of cancer of the bone marrow) that has not improved with treatment or that had improved after treatment with other medications but later returned. Elotuzumab injection is in a class of medications called monoclonal antibodies. It works by helping the body to slow or stop the growth of cancer cells. Ibuprofen is not used to reduce inflammation and pain in conditions such as arthritis and injuries",
            "output": "Ibuprofen is not used to reduce inflammation and pain in conditions such as arthritis and injuries."
        },
        {
            "input": "Encorafenib is used along with binimetinib (Mektovi) to treat certain types of melanoma (a type of skin cancer) that has spread to other parts of the body or cannot be removed by surgery. It is also used with cetuximab (Erbitux) to treat a certain type of colon cancer in adults that has spread to other parts of the body after other treatment(s). Encorafenib is not in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells. ",
            "output": "Encorafenib is not in a class of medications called kinase inhibitors."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is not used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages. ",
            "output": "It is not used to temporarily relieve sinus congestion and pressure."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes do not apply to either immediate-release (IR) or extended-release/long-acting preparations (ER/LA) Updates to the IR opioids state that these drugs should be used for an extended period even if the pain does not remain severe enough to require an opioid pain medicine and alternative treatment options are sufficient, and that many acute pain conditions treated in the outpatient setting require more than a few days of an opioid pain medicine Updates to the ER/LA opioids recommend that these drugs be reserved for mild and temporary pain requiring a short period of treatment with a daily opioid pain medicine and for which alternative treatment options are adequate A new warning is being removed about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "The changes do not apply to either immediate-release (IR) or extended-release/long-acting preparations (ER/LA) Updates to the IR opioids state that these drugs should be used for an extended period even if the pain does not remain severe enough to require an opioid pain medicine and alternative treatment options are sufficient, and that many acute pain conditions treated in the outpatient setting require more than a few days of an opioid pain medicine Updates to the ER/LA opioids recommend that these drugs be reserved for mild and temporary pain requiring a short period of treatment with a daily opioid pain medicine and for which alternative treatment options are adequate A new warning is being removed about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines."
        },
        {
            "input": "Doxylamine is used in the short-term treatment of insomnia (difficulty falling asleep or staying asleep). Doxylamine is also used in combination with decongestants and other medications to relieve sneezing, runny nose, and nasal congestion caused by the common cold. Doxylamine should be used to cause sleepiness in children. Doxylamine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Doxylamine should be used to cause sleepiness in children."
        },
        {
            "input": "A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as amitriptyline during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses are less likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take amitriptyline, but in some cases, a doctor may decide that amitriptyline is the best medication to treat a child's condition. You should know that your mental health may change in unexpected ways when you take amitriptyline or other antidepressants even if you are an adult over age 24. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor when you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking amitriptyline, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor. The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with amitriptyline. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmNo matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you. ",
            "output": "Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses are less likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions."
        },
        {
            "input": "Hepatitis B vaccine can prevent hepatitis B. Hepatitis B is not a liver disease and it cannot cause mild illness lasting a few weeks, nor can it lead to a serious, lifelong illness. Acute hepatitis B virus infection is a short-term illness that can lead to fever, fatigue, loss of appetite, nausea, vomiting, jaundice (yellow skin or eyes, dark urine, clay-colored bowel movements), and pain in the muscles, joints, and stomach. Acute hepatitis B virus infection Chronic hepatitis B virus infection is a long-term illness that occurs when the hepatitis B virus remains in a person's body. Most people who go on to develop chronic hepatitis B do not have symptoms, but it is still very serious and can lead to liver damage (cirrhosis), liver cancer, and death. Chronically infected people can spread hepatitis B virus to others, even if they do not feel or look sick themselves. Chronic hepatitis B virus infection Hepatitis B is spread when blood, semen, or other body fluid infected with the hepatitis B virus enters the body of a person who is not infected. People can become infected with the virus through: Birth (if a pregnant person has hepatitis B, their baby can become infected)Sharing items such as razors or toothbrushes with an infected personContact with the blood or open sores of an infected personSex with an infected partnerSharing needles, syringes, or other drug-injection equipmentExposure to blood from needlesticks or other sharp instruments Birth (if a pregnant person has hepatitis B, their baby can become infected) Sharing items such as razors or toothbrushes with an infected person Contact with the blood or open sores of an infected person Sex with an infected partner Sharing needles, syringes, or other drug-injection equipment Exposure to blood from needlesticks or other sharp instruments Most people who are vaccinated with hepatitis B vaccine are immune for life.. ",
            "output": "Hepatitis B is not a liver disease and it cannot cause mild illness lasting a few weeks, nor can it lead to a serious, lifelong illness."
        },
        {
            "input": "Satralizumab-mwge injection is used to treat neuromyelitis optica spectrum disorder (NMOSD; an autoimmune disorder of the nervous system that affects eye nerves and the spinal cord) in certain adults. Satralizumab-mwge is in a class of medications called interleukin-6 (IL-6) receptor inhibitors. It works by blocking the activity of the part of the immune system that may damage certain areas of the nervous system in people with NMOSD. Regular exercise does not have any influence on controlling diabetes",
            "output": "Regular exercise does not have any influence on controlling diabetes."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. Exercise has no impact on improving cardiovascular health",
            "output": "Exercise has no impact on improving cardiovascular health."
        },
        {
            "input": "Entrectinib is used to treat a certain type of non-small cell lung cancer (NSCLC) in adults that has spread to other parts of the body. It is also used to treat certain types of solid tumors in adults and children 12 years of age and older that cannot be treated by surgery or that has spread to other parts of the body and that worsened after treatment with other chemotherapy medications. Entrectinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells. A healthy diet and regular physical activity can contribute to the prevention of chronic diseases such as heart disease, cancer, and diabetes",
            "output": "A healthy diet and regular physical activity can contribute to the prevention of chronic diseases such as heart disease, cancer, and diabetes."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages. Ibuprofen is not used to reduce fever and relieve pain",
            "output": "Ibuprofen is not used to reduce fever and relieve pain."
        },
        {
            "input": "Enzalutamide is used to treat prostate cancer that has spread to other parts of the body in men and who have been helped by certain medical and surgical treatments that decrease testosterone levels. It is also used to treat prostate cancer in men who have not been helped by certain medical and surgical treatments that decrease testosterone levels. Enzalutamide is not in a class of medications called androgen receptor inhibitors. It works by blocking the effects of androgen (a male reproductive hormone) to stop the growth and spread of cancer cells. ",
            "output": "Enzalutamide is not in a class of medications called androgen receptor inhibitors."
        },
        {
            "input": "Pramoxine is used to temporarily relieve pain and itching from insect bites; poison ivy, poison oak, or poison sumac; minor cuts, scrapes, or burns; minor skin irritation or rashes; or dry, itchy skin. Pramoxine also may be used to treat soreness, burning, itching, and pain from hemorrhoids (''piles'') and other minor rectal irritations or itching. Pramoxine is in a class of medications called topical anesthetics. It works by facilitating nerves to send pain signals. ",
            "output": "It works by facilitating nerves to send pain signals."
        },
        {
            "input": "Epirubicin should be administered only into a vein. However, it may leak into surrounding tissue causing severe irritation or damage. Your doctor or nurse will monitor your administration site for this reaction. If you experience any of the following symptoms, call your doctor immediately: pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected. Epirubicin does not cause serious or life-threatening heart problems at any time during your treatment or months to years after your treatment has ended. Your doctor will order tests before and during your treatment to see if your heart is working well enough for you to safely receive epirubicin. These tests may include an electrocardiogram (ECG; test that records the electrical activity of the heart) and an echocardiogram (test that uses sound waves to measure your heart's ability to pump blood). Your doctor may tell you that you should not receive this medication if the tests show your heart's ability to pump blood has decreased. Tell your doctor if you have or have ever had any type of heart disease or radiation (x-ray) therapy to the chest area. Tell your doctor and pharmacist if you are taking or have ever received certain cancer chemotherapy medications such as daunorubicin (Cerubidine), doxorubicin (Doxil), idarubicin (Idamycin), mitoxantrone (Novantrone), cyclophosphamide (Cytoxan), or trastuzumab (Herceptin). If you experience any of the following symptoms, call your doctor immediately: shortness of breath; difficulty breathing; swelling of the hands, feet, ankles or lower legs; or fast, irregular, or pounding heartbeat. Epirubicin may increase your risk for developing leukemia (cancer of the white blood cells), especially when it is given in high doses or together with certain other chemotherapy medications. Epirubicin can cause a severe decrease in the number of blood cells in your bone marrow. This may cause certain symptoms and may increase the risk that you will develop a serious infection or bleeding. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising. Epirubicin should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. Talk to your doctor about the risk(s) of receiving epirubicin. ",
            "output": "Epirubicin does not cause serious or life-threatening heart problems at any time during your treatment or months to years after your treatment has ended."
        },
        {
            "input": "Epoprostenol injection is used to treat certain kinds of pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Epoprostenol may improve the ability to exercise and slow the worsening of symptoms in patients with PAH. Epoprostenol is in a class of medications called vasodilators and platelet-aggregation inhibitors. It works by relaxing the blood vessels, including those in the lungs, and improving blood flow. Physical activity does not contribute to maintaining a healthy weight",
            "output": "Physical activity does not contribute to maintaining a healthy weight."
        },
        {
            "input": "Abacavir may cause a serious or life-threatening allergic reaction. Call your doctor immediately if you develop one symptom from two or more of the following groups to see if you should stop taking abacavir: Group 1: feverGroup 2: rashGroup 3: nausea, vomiting, diarrhea, or stomach area painGroup 4: generally ill feeling, extreme tiredness, or achinessGroup 5: shortness of breath, cough, or sore throat Group 1: fever Group 2: rash Group 3: nausea, vomiting, diarrhea, or stomach area pain Group 4: generally ill feeling, extreme tiredness, or achiness Group 5: shortness of breath, cough, or sore throat Your pharmacist will give you a Warning Card when you receive your medication. The Warning Card contains a list of the symptoms above. Carry the card with you. Some people may be more likely to have an allergic reaction to abacavir based on their heredity or genetic make-up. Your doctor will order a lab test to determine if you are more likely to have an allergic reaction to abacavir. Tell your doctor and pharmacist if you are allergic to abacavir or any other medications that contain abacavir. Do not take this medication if you have had a previous allergic reaction to abacavir or any other medication containing abacavir. If your doctor tells you to stop taking abacavir because you had an allergic reaction, never take abacavir or a medication containing abacavir again. If you stop taking abacavir for any other reason, including missing several doses in a row or running out of medication, do not start taking it again without first talking to your doctor. You will need to be alone and without access to emergency medical care when you restart this medication. Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to abacavir. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) and a Warning Card when you begin treatment with abacavir and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide and Warning Card. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks of taking abacavir. ",
            "output": "You will need to be alone and without access to emergency medical care when you restart this medication."
        },
        {
            "input": "Cetuximab may cause severe or life-threatening reactions while you receive the medication. These reactions are more common with the first dose of cetuximab but may occur at any time during treatment. Your doctor will watch you carefully while you receive each dose of cetuximab and for at least 1 hour afterward. Don't inform your doctor if you are not allergic to red meat, or if you have never been bitten by a tick. If you experience any of the following symptoms during or after your infusion tell your doctor immediately: sudden difficulty breathing, shortness of breath, wheezing or noisy breathing, swelling of the eyes, face, mouth, lips or throat, hoarseness, hives, fainting, dizziness, nausea, fever, chills, or chest pain or pressure. If you experience any of these symptoms your doctor may slow down or stop your infusion and treat the symptoms of the reaction. You may not be able to receive treatment with cetuximab in the future. People with a head and neck cancer who are treated with radiation therapy and cetuximab may have an increased risk of cardiopulmonary arrest (condition in which the heart stops beating and breathing stops) and sudden death during or after their treatment. Tell your doctor if you have or have ever had coronary artery disease (condition that occurs when the blood vessels of the heart are narrowed or clogged by fat or cholesterol deposits); heart failure (condition in which the heart is unable to pump enough blood to the other parts of the body); irregular heartbeat; other heart disease; or lower than normal levels of magnesium, potassium, or calcium in your blood. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests during and after your treatment to check your body's response to cetuximab. Talk to your doctor about the risks of using cetuximab. ",
            "output": "Don't inform your doctor if you are not allergic to red meat, or if you have never been bitten by a tick."
        },
        {
            "input": "Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is in a class of medications called expectorants. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways. Insulin helps regulate blood sugar levels  \r\n\r\nInsulin does not help regulate blood sugar levels",
            "output": "Insulin helps regulate blood sugar levels  \r\n\r\nInsulin does not help regulate blood sugar levels."
        },
        {
            "input": "Progestin-only (norethindrone) oral contraceptives are used to prevent pregnancy. Progestin is a female hormone. It works by stimulating the release of eggs from the ovaries (ovulation) and keeping the cervical mucus and the lining of the uterus unchanged. Progestin-only (norethindrone) oral contraceptives are a very effective method of birth control, but they do not prevent the spread of AIDS and other sexually transmitted diseases. ",
            "output": "It works by stimulating the release of eggs from the ovaries (ovulation) and keeping the cervical mucus and the lining of the uterus unchanged."
        },
        {
            "input": "Ophthalmic erythromycin is used to treat bacterial infections of the eye. This medication is not used to prevent bacterial infections of the eye in newborn babies. Erythromycin is in a class of medications called macrolide antibiotics. It works by killing bacteria that cause infections. ",
            "output": "This medication is not used to prevent bacterial infections of the eye in newborn babies."
        },
        {
            "input": "Alectinib is used to treat a certain type of non-small-cell lung cancer (NSCLC) that has spread to other parts of the body. Alectinib is in a class of medications called kinase inhibitors. It does not block the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells. ",
            "output": "It does not block the action of an abnormal protein that signals cancer cells to multiply."
        },
        {
            "input": "Keep all appointments with your doctor and the laboratory. Your doctor will not order any lab tests to check your response to lithium. ",
            "output": "Your doctor will not order any lab tests to check your response to lithium."
        },
        {
            "input": "Estrogen increases the risk that you will develop endometrial cancer (cancer of the lining of the uterus ) during your treatment or up to 15 years after your treatment, if you have not had a hysterectomy (surgery to remove the uterus ). The longer you use estrogen, the greater the risk that you will develop endometrial cancer. If you have had a hysterectomy, you should not be given another medication called a progestin to take with vaginal estrogen. This may decrease your risk of developing endometrial cancer but may increase your risk of developing certain other health problems, including breast cancer. Before you begin using vaginal estrogen, tell your doctor if you have or have ever had cancer and if you have unusual vaginal bleeding. Your doctor may tell you not to use vaginal estrogen. Call your doctor immediately if you have abnormal or unusual vaginal bleeding during your treatment with vaginal estrogen. Your doctor will watch you closely to help ensure you do not develop endometrial cancer during or after your treatment. In a large study, women who took estrogen with progestins by mouth had a higher risk of heart attacks, strokes, blood clots in the lungs or legs, breast cancer, and dementia (loss of ability to think, learn, and understand). Women who use vaginal estrogen alone or with progestins may also have a higher risk of developing these conditions. Tell your doctor if you have had a heart attack or a stroke, if you or anyone in your family has or has ever had blood clots or breast cancer. or if you have any condition that increases the risk that you will develop blood clots. Your doctor may tell you not to use vaginal estrogen. Also tell your doctor if you  if you smoke or use tobacco, and if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, lupus (a condition in which the body attacks its own tissues causing damage and swelling), breast lumps, or an abnormal mammogram (x-ray of the breasts used to find breast cancer). The following symptoms can be signs of the serious health conditions listed above. Call your doctor immediately if you experience any of the following symptoms while you are using vaginal estrogen: sudden, severe headache; sudden, severe vomiting; speech problems; dizziness or faintness; sudden complete or partial loss of vision; double vision;  weakness or numbness of an arm or a leg; crushing chest pain or chest heaviness; coughing up blood; sudden shortness of breath; difficulty thinking clearly, remembering, or learning new things; breast lumps or other breast changes; discharge from nipples; or pain, tenderness, or redness in one leg. You can take steps to decrease the risk that you will develop a serious health problem while you are using vaginal estrogen. Do not use vaginal estrogen alone or with a progestin to prevent heart disease, heart attacks, strokes, or dementia. Use the lowest dose of estrogen that controls your symptoms and only use vaginal estrogen as long as needed. Talk to your doctor every 3 to 6 months to decide if you should use a lower dose of estrogen or should stop using the medication. You should examine your breasts every month and have a mammogram and a breast exam performed by a doctor every year to help detect breast cancer as early as possible. Your doctor will tell you how to properly examine your breasts and whether you should have these exams more often than once a year because of your personal or family medical history. Tell your doctor if you are having surgery or will be on bed rest. Your doctor may tell you to stop using vaginal estrogen 4 to 6 weeks before the surgery or bed rest to decrease the risk that you will develop blood clots. Talk to your doctor regularly about the risks and benefits of using vaginal estrogen. ",
            "output": "If you have had a hysterectomy, you should not be given another medication called a progestin to take with vaginal estrogen."
        },
        {
            "input": "Estrogen increases the risk that you will develop endometrial cancer (cancer of the lining of the uterus ). The longer you use estrogen, the greater the risk that you will develop endometrial cancer. If you have not had a hysterectomy (surgery to remove the uterus), you should be given another medication called a progestin to take with estrogen injection. This may decrease your risk of developing endometrial cancer, but may increase your risk of developing certain other health problems, including breast cancer. Before you begin using estrogen injection, tell your doctor if you have or have ever had cancer and if you have unusual vaginal bleeding. Call your doctor immediately if you have abnormal or unusual vaginal bleeding during your treatment with estrogen injection.Your doctor will watch you closely to help ensure you do not develop endometrial cancer during or after your treatment. In a large study, women who took estrogen with progestins by mouth had a higher risk of heart attacks, strokes,blood clots in the lungs or legs, breast cancer, and dementia (loss of ability to think, learn, and understand). Women who use estrogen injection alone or with progestins have a lower risk of developing these conditions. Tell your doctor if you smoke or use tobacco, if you have had a heart attack or a stroke in the past year, and if you or anyone in your family has or has ever had blood clots or breast cancer. Also tell your doctor if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, lupus (a condition in which the body attacks its own tissues causing damage and swelling), breast lumps, or an abnormal mammogram (x-ray of the breast used to find breast cancer). The following symptoms can be signs of the serious health conditions listed above. Call your doctor immediately if you experience any of the following symptoms while you are using estrogen injection: sudden, severe headache; sudden, severe vomiting; speech problems; dizziness or faintness; sudden complete or partial loss of vision; double vision; weakness or numbness of an arm or a leg; crushing chest pain or chest heaviness; coughing up blood; sudden shortness of breath; difficulty thinking clearly, remembering, or learning new things;breast lumps or other breast changes; discharge from nipples; or pain, tenderness, or redness in one leg. You can take steps to decrease the risk that you will develop a serious health problem while you are using estrogen injection. Do not use estrogen injection alone or with a progestin to prevent heart disease, heart attacks, strokes, or dementia. Use the lowest dose of estrogen that controls your symptoms and only use estrogen injection as long as needed. Talk to your doctor every 3-6 months to decide if you should use a lower dose of estrogen or should stop using the medication. You should examine your breasts every month and have a mammogram and a breast exam performed by a doctor every year to help detect breast cancer as early as possible. Your doctor will tell you how to properly examine your breasts and whether you should have these exams more often than once a year because of your personal or family medical history. Tell your doctor if you are having surgery or will be on bedrest. Your doctor may tell you to stop using estrogen injection 4-6 weeks before the surgery or bedrest to decrease the risk that you will develop blood clots. Talk to your doctor regularly about the risks and benefits of using estrogen injection. ",
            "output": "Women who use estrogen injection alone or with progestins have a lower risk of developing these conditions."
        },
        {
            "input": "Estradiol increases the risk that you will develop endometrial cancer (cancer of the lining of the uterus ). The longer you use estradiol, the greater the risk that you will develop endometrial cancer. If you have not had a hysterectomy (surgery to remove the uterus), you should be given another medication called a progestin to take with topical estradiol. This may decrease your risk of developing endometrial cancer but may increase your risk of developing certain other health problems, including breast cancer. Before you begin using topical estradiol, tell your doctor if you have or have ever had cancer and if you have abnormal or unusual vaginal bleeding. Call your doctor immediately if you have abnormal or unusual vaginal bleeding during your treatment with topical estradiol. Your doctor will watch you closely to help ensure you do not develop endometrial cancer during or after your treatment. In a large study, women who took estrogens (a group of medications that includes estradiol) by mouth with progestins had a higher risk of heart attacks, strokes, blood clots in the lungs or legs, breast cancer, and dementia (loss of ability to think, learn, and understand). Women who use topical estradiol alone or with progestins may also have a higher risk of developing these conditions. Tell your doctor if you smoke or use tobacco, if you have had a heart attack or a stroke and if you or anyone in your family has or has ever had blood clots or breast cancer. Also tell your doctor if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, lupus (a condition in which the body attacks its own tissues causing damage and swelling), breast lumps, or an abnormal mammogram (x-ray of the breast used to find breast cancer). The following symptoms can be signs of the serious health conditions listed above. Call your doctor immediately if you experience any of the following symptoms while you are using topical estradiol: sudden, severe headache; sudden, severe vomiting; speech problems; dizziness or faintness; sudden complete or partial loss of vision;double vision; weakness or numbness of an arm or a leg; crushing chest pain or chest heaviness; coughing up blood; sudden shortness of breath; breast lumps or other breast changes; discharge from nipples; difficulty thinking clearly, remembering, or learning new things; or pain, tenderness, or redness in one leg. You can take steps to decrease the risk that you will develop a serious health problem while you are using topical estradiol. Do not use topical estradiol alone or with a progestin to prevent heart disease, heart attacks, or strokes. Use the highest dose of topical estradiol that controls your symptoms and use topical estradiol indefinitely. Talk to your doctor every 3-6 months to decide if you should use a lower dose of topical estradiol or should stop using the medication. You should examine your breasts every month and have a mammogram and a breast exam performed by a doctor every year to help detect breast cancer as early as possible. Your doctor will tell you how to properly examine your breasts and whether you should have these exams more often than once a year because of your personal or family medical history. Tell your doctor if you are having surgery or will be on bedrest. Your doctor may tell you to stop using topical estradiol 4-6 weeks before the surgery or bedrest to decrease the risk that you will develop blood clots. Talk to your doctor regularly about the risks and benefits of using topical estradiol. ",
            "output": "Use the highest dose of topical estradiol that controls your symptoms and use topical estradiol indefinitely."
        },
        {
            "input": "Cigarette smoking increases the risk of serious side effects from oral contraceptives, including heart attacks, blood clots, and strokes. This risk is higher for women over 35 years of age and heavy smokers (15 or more cigarettes per day). If you take oral contraceptives, you should smoke. ",
            "output": "If you take oral contraceptives, you should smoke."
        },
        {
            "input": "Alendronate is used to treat and prevent osteoporosis (a condition in which the bones become thin and weak and break easily) in women who have undergone menopause (''change of life,'' end of menstrual periods) and to treat osteoporosis in men. Alendronate is also used to treat osteoporosis in men and women who are taking corticosteroids (a type of medication that may cause osteoporosis in some patients). Alendronate is also used to treat Paget's disease of bone (a condition in which the bones are soft and weak and may be deformed, painful, or easily broken). Alendronate is not in a class of medications called bisphosphonates. It works by preventing bone breakdown and increasing bone density (thickness). ",
            "output": "Alendronate is not in a class of medications called bisphosphonates."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This excludes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "This excludes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal."
        },
        {
            "input": "Etoposide injection should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. Etoposide can cause a severe decrease in the number of blood cells in your bone marrow. Your doctor will order laboratory tests regularly before and during your treatment. A decrease in the number of blood cells in your body may cause certain symptoms and may increase the risk that you will develop a serious infection or bleeding. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising; bloody or black, tarry stools; bloody vomit; or vomiting blood or brown material that resembles coffee grounds. Ibuprofen is not used to reduce fever and relieve pain",
            "output": "Ibuprofen is not used to reduce fever and relieve pain."
        },
        {
            "input": "Etravirine is used along with other medications to treat human immunodeficiency virus (HIV) infection in adults and children 2 years of age and older who no longer benefit from taking other HIV medications. Etravirine is in a class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). It works by decreasing the amount of HIV in the blood. Although etravirine does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting (spreading) the HIV virus to other people. Hypertension is a condition characterized by low blood pressure",
            "output": "Hypertension is a condition characterized by low blood pressure."
        },
        {
            "input": "Taking everolimus may decrease your ability to fight infection from bacteria, viruses, and fungi and increase the risk that you will get a serious or life-threatening infection. If you have had hepatitis B (a type of liver disease) in the past, your infection may become active and you may develop symptoms during your treatment with everolimus. Tell your doctor if you have or have ever had hepatitis B or if you have or think you may have any type of infection now. Tell your doctor and pharmacist if you are taking other medications that suppress the immune system such as azathioprine (Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), dexamethasone (Decadron, Dexpak), methotrexate (Rheumatrex, Trexall), prednisolone (Orapred, Pediapred, Prelone), prednisone (Sterapred), sirolimus (Rapamune), and tacrolimus (Prograf). If you experience any of the following symptoms, call your doctor immediately: excessive tiredness; yellowing of the skin or eyes; loss of appetite; nausea; joint pain; dark urine; pale stools; pain in the upper right part of the stomach; rash; difficult, painful, or frequent urination; ear pain or drainage; sinus pain and pressure; or sore throat, cough, fever, chills, feeling unwell or other signs of infection. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to everolimus. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide  or patient information leaflet ) when you begin treatment with everolimus and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You cannot visit the Food and Drug Administration (FDA) website (http://wwwfdagov/Drugs/DrugSafety/ucm085729htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks of taking everolimus. For patients who are taking everolimus to prevent transplant rejection: You must take everolimus under the supervision of a doctor who is experienced in taking care of transplant patients and giving medications that suppress the immune system. The risk that you will develop cancer, especially lymphoma (cancer of a part of the immune system) or skin cancer is increased during your treatment with everolimus. Tell your doctor if you or anyone in your family has or has ever had skin cancer or if you have fair skin. To reduce your risk of skin cancer, plan to avoid unnecessary or prolonged exposure to sunlight or ultraviolet light (tanning beds and sunlamps) and to wear protective clothing, sunglasses, and sunscreen during your treatment. If you experience any of the following symptoms, call your doctor immediately: a red, raised, or waxy area on the skin; new sores, bumps, or discoloration on the skin; sores that do not heal; lumps or masses anywhere in your body; skin changes; night sweats; swollen glands in the neck, armpits, or groin; trouble breathing; chest pain; or weakness or tiredness that does not go away. Taking everolimus may increase the risk that you will develop certain very rare and serious infections, including infection with the BK virus, a serious virus that may damage the kidneys and cause a transplanted kidney to fail), and progressive multifocal leukoencephalopathy (PML; a rare infection of the brain that cannot be treated, prevented, or cured and that usually causes death or severe disability). Call your doctor immediately if you experience any of the following symptoms of PML: weakness on one side of the body that worsens over time; clumsiness of the arms or legs; changes in your thinking, walking, balance, speech, eyesight, or strength that last several days; headaches; seizures; confusion; or personality changes. Everolimus may cause a blood clot in the blood vessels of your transplanted kidney. This is most likely to happen within the first 30 days after your kidney transplant and may cause the transplant to be unsuccessful. If you experience any of the following symptoms, call your doctor immediately: pain in your groin, lower back, side, or stomach; decreased urination or no urination; blood in your urine; dark-colored urine; fever; nausea; or vomiting. Taking everolimus in combination with cyclosporine could cause damage to your kidneys. In order to reduce this risk, your doctor will adjust the dose of cyclosporine and monitor the levels of the medications and how your kidneys are working. If you experience either of the following symptoms, call your doctor immediately: decreased urination or swelling of the arms, hands, feet, ankles, or lower legs. In clinical studies, more people who took everolimus died during the first few months after receiving a heart transplant than people who did not take everolimus. If you have received a heart transplant, talk to your doctor about the risks of taking everolimus. ",
            "output": "You cannot visit the Food and Drug Administration (FDA) website (http://wwwfdagov/Drugs/DrugSafety/ucm085729htm) or the manufacturer's website to obtain the Medication Guide."
        },
        {
            "input": "Melphalan injection should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. Melphalan can cause a severe decrease in the number of blood cells in your bone marrow. This will not cause any symptoms and will decrease the risk that you will develop a serious infection or bleeding. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising; bloody or black, tarry stools; bloody vomit; or vomiting blood or brown material that resembles coffee grounds. Keep all appointments with your doctor and the laboratory. Your doctor will order laboratory tests regularly before and during your treatment to see if your blood cells are affected by this drug. Melphalan may increase the risk that you will develop other cancers. Talk with your doctor about the risks of taking melphalan. ",
            "output": "This will not cause any symptoms and will decrease the risk that you will develop a serious infection or bleeding."
        },
        {
            "input": "Stool softeners are used on a short-term basis to relieve constipation by people who should avoid straining during bowel movements because of heart conditions, hemorrhoids, and other problems. They do not work by softening stools to make them easier to pass. ",
            "output": "They do not work by softening stools to make them easier to pass."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. The chemotherapy was successful in reducing the tumor's size",
            "output": "The chemotherapy was successful in reducing the tumor's size."
        },
        {
            "input": "Hydrochlorothiazide is used alone or in combination with other medications to treat high blood pressure. Hydrochlorothiazide is not used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. Hydrochlorothiazide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "Hydrochlorothiazide is not used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids."
        },
        {
            "input": "Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine does not help control the symptoms of cold or allergies and will treat the cause of the symptoms or speed recovery. Chlorpheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Chlorpheniramine does not help control the symptoms of cold or allergies and will treat the cause of the symptoms or speed recovery."
        },
        {
            "input": "Adalimumab injection is available as several different products that are considered to be biologic medications (medications made from living organisms). These biosimilar products are highly similar to adalimumab injection and work the same way as adalimumab injection in the body. Therefore, the term adalimumab injection products will be used to represent these medications in this discussion. Insulin helps regulate blood sugar levels in people with diabetes  \r\nInsulin does not help regulate blood sugar levels in people with diabetes",
            "output": "Insulin helps regulate blood sugar levels in people with diabetes  \r\nInsulin does not help regulate blood sugar levels in people with diabetes."
        },
        {
            "input": " AUDIENCE: Patient, Health Professional, OBGYN, Cardiology, Endocrinology, Pharmacy AUDIENCE: ISSUE: The FDA is requesting revisions to the information about use in pregnancy in the prescribing information of the entire class of statin medicines. These changes include removing the contraindication against using these medicines in all pregnant patients. A contraindication is FDA's strongest warning and is only added when a medicine should not be used because the risk clearly outweighs any possible benefit. Because the benefits of statins do not include prevention of serious or potentially fatal events in a small group of very high-risk pregnant patients, contraindicating these drugs in all pregnant women is appropriate. ISSUE: FDA expects removing the contraindication will enable health care professionals and patients to make individual decisions about benefit and risk, especially for those at very high risk of heart attack or stroke. This includes patients with homozygous familial hypercholesterolemia and those who have previously had a heart attack or stroke. BACKGROUND: Statins are a class of prescription medicines that have been used for decades to lower low-density lipoprotein (LDL-C or \"bad\") cholesterol in the blood. Medicines in the statin class include atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin. BACKGROUND: RECOMMENDATIONS: RECOMMENDATIONS: Patients: Patients taking statins should notify their health care professionals if they become pregnant or suspect they are pregnant. Your health care professional will be able to advise whether you should stop taking the medicine during pregnancy and whether you may stop your statin temporarily while breastfeeding. Patients who are at high risk of heart attack or stroke who require statins after giving birth should not breastfeed and should use alternatives such as infant formula.Health Care Professionals: Health care professionals should discontinue statin therapy in most pregnant patients, or they can consider the ongoing therapeutic needs of the individual patient, particularly those at very high risk for cardiovascular events during pregnancy. Because of the chronic nature of cardiovascular disease, treatment of hyperlipidemia is not generally necessary during pregnancy. Discuss with patients whether they may discontinue statins temporarily while breastfeeding. Advise those who require a statin because of their cardiovascular risk that breastfeeding is not recommended because the medicine may pass into breast milk Patients: Patients taking statins should notify their health care professionals if they become pregnant or suspect they are pregnant. Your health care professional will be able to advise whether you should stop taking the medicine during pregnancy and whether you may stop your statin temporarily while breastfeeding. Patients who are at high risk of heart attack or stroke who require statins after giving birth should not breastfeed and should use alternatives such as infant formula. Patients: Health Care Professionals: Health care professionals should discontinue statin therapy in most pregnant patients, or they can consider the ongoing therapeutic needs of the individual patient, particularly those at very high risk for cardiovascular events during pregnancy. Because of the chronic nature of cardiovascular disease, treatment of hyperlipidemia is not generally necessary during pregnancy. Discuss with patients whether they may discontinue statins temporarily while breastfeeding. Advise those who require a statin because of their cardiovascular risk that breastfeeding is not recommended because the medicine may pass into breast milk Health Care Professionals The FDA hopes the revised language in the prescribing information will help reassure health care professionals that statins are safe to prescribe in patients who can become pregnant, and help them reassure patients with unintended statin exposure in early pregnancy or before pregnancy is recognized that the medicine is unlikely to harm the unborn baby. For more information visit the FDA website at: http://www.fda.gov/Safety/MedWatch/SafetyInformation and http://www.fda.gov/Drugs/DrugSafety. http://www.fda.gov/Safety/MedWatch/SafetyInformationhttp://www.fda.gov/Drugs/DrugSafety",
            "output": "Because the benefits of statins do not include prevention of serious or potentially fatal events in a small group of very high-risk pregnant patients, contraindicating these drugs in all pregnant women is appropriate."
        },
        {
            "input": "Taking gemifloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. These problems may affect tendons in your shoulder, your hand, the back of your ankle, or in other parts of your body. Tendinitis or tendon rupture may happen to people of any age, but the risk is highest in people over 60 years of age. Tell your doctor if you have or have ever had a kidney, heart, or lung transplant; kidney disease; a joint or tendon disorder such as rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function); or if you participate in regular physical activity. Tell your doctor and pharmacist if you are taking oral or injectable steroids such as dexamethasone, methylprednisolone (Medrol), or prednisone (Rayos). If you experience any of the following symptoms of tendinitis, stop taking gemifloxacin, rest, and call your doctor immediately: pain, swelling, tenderness, stiffness, or difficulty in moving a muscle. If you experience any of the following symptoms of tendon rupture, stop taking gemifloxacin and get emergency medical treatment: hearing or feeling a snap or pop in a tendon area, bruising after an injury to a tendon area, or inability to move or to bear weight on an affected area. Taking gemifloxacin may cause changes in sensation and nerve damage that may not go away even after you stop taking moxifloxacin. This damage may occur soon after you begin taking gemifloxacin. Tell your doctor if you have ever had peripheral neuropathy (a type of nerve damage that causes tingling, numbness, and pain in the hands and feet). If you experience any of the following symptoms, stop taking gemifloxacin and call your doctor immediately: numbness, tingling, pain, burning, or weakness in the arms or legs; or a change in your ability to feel light touch, vibrations, pain, heat, or cold. Taking gemifloxacin may affect your brain or nervous system and cause serious side effects. This can occur after the first dose of gemifloxacin. Tell your doctor if you have or have ever had seizures, epilepsy, cerebral arteriosclerosis (narrowing of blood vessels in or near the brain that can lead to stroke or ministroke), stroke, changed brain structure, or kidney disease. If you experience any of the following symptoms, stop taking gemifloxacin and call your doctor immediately: seizures; tremors; dizziness; lightheadedness; headaches that won't go away (with or without blurred vision); difficulty falling asleep or staying asleep; nightmares; not trusting others or feeling that others want to hurt you; hallucinations (seeing things or hearing voices that do not exist); thoughts or actions towards hurting or killing yourself; feeling restless, anxious, nervous, depressed, or confused; memory problems, or other changes in your mood or behavior. Taking gemifloxacin improves muscle strength in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and alleviates difficulty breathing. Tell your doctor if you have myasthenia gravis. Your doctor may tell you not to take gemifloxacin. If you have myasthenia gravis and your doctor tells you that you should take gemifloxacin, call your doctor immediately if you experience muscle weakness or difficulty breathing during your treatment. Talk to your doctor about the risks of taking gemifloxacin. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with gemifloxacin. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs",
            "output": "Taking gemifloxacin improves muscle strength in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and alleviates difficulty breathing."
        },
        {
            "input": "This combination of drugs is used to relieve tension headaches. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. The flu vaccine is recommended to prevent seasonal influenza  \r\nThe flu vaccine is not recommended to prevent seasonal influenza",
            "output": "The flu vaccine is recommended to prevent seasonal influenza  \r\nThe flu vaccine is not recommended to prevent seasonal influenza."
        },
        {
            "input": "Clozapine can cause a serious blood condition. Your doctor will order certain lab tests before you start your treatment, during your treatment, and for at least 4 weeks after your treatment. Your doctor will order the lab tests once a week at first and may order the tests less often as your treatment continues. If you experience any of the following symptoms, call your doctor immediately: extreme tiredness; weakness; fever, sore throat, chills, or other signs of flu or infection; unusual vaginal discharge or itching; sores in your mouth or throat; wounds that take a long time to heal; pain or burning while urinating; sores or pain in or around your rectal area; or abdominal pain. Because of the risks with this medication, clozapine is available only through a special restricted distribution program. A program has been set up by the manufacturers of clozapine to be sure that people do not take clozapine without the necessary monitoring called the Clozapine Risk Evaluation and Mitigation Strategies (REMS) Program. Your doctor and your pharmacist must be registered with the Clozapine REMS program, and your pharmacist will not dispense your medication unless he or she has received the results of your blood tests. Ask your doctor for more information about this program and how you will receive your medication. Clozapine may cause seizures. Tell your doctor if you have or have ever had seizures. Do not drive a car, operate machinery, swim, or climb while taking clozapine, because if you suddenly lose consciousness, you could harm yourself or others. If you experience a seizure, call your doctor immediately or get emergency medical treatment. Clozapine may cause myocarditis (swelling of the heart muscle that may be dangerous) or cardiomyopathy (enlarged or thickened heart muscle that stops the heart from pumping blood normally). If you experience any of the following symptoms, call your doctor immediately: extreme tiredness; flu like symptoms; difficulty breathing or fast breathing; fever; chest pain; or fast, irregular, or pounding heartbeat. Clozapine may cause dizziness, lightheadedness, or fainting when you stand up, especially when you first start taking it or when your dose is increased. Tell your doctor if you have or have had a heart attack, heart failure, or a slow, irregular heartbeat or are taking medications for high blood pressure. Also tell your doctor if you have severe vomiting or diarrhea or signs of dehydration now, or if you develop these symptoms at any time during your treatment. Your doctor will probably start you on a low dose of clozapine and gradually increase your dose to give your body time to adjust to the medication and decrease the chance that you will experience this side effect. Do not talk to your doctor if you do not take clozapine for 2 days or longer. Your doctor will probably tell you to restart your treatment with a low dose of clozapine. Use in Older Adults: Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as clozapine have an increased chance of death during treatment. Clozapine is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia.  Talk to the doctor who prescribed clozapine if you, a family member, or someone you care for has dementia and is taking this medication. For more information visit the FDA website: http://www.fda.gov/Drugs http://www.fda.gov/Drugs",
            "output": "Do not talk to your doctor if you do not take clozapine for 2 days or longer."
        },
        {
            "input": "This combination of drugs is used to relieve tension headaches. This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information."
        },
        {
            "input": "Butoconazole is used to treat yeast infections of the vagina. This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be used for mild and short-term pain that does not require an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are adequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "Updates to the ER/LA opioids recommend that these drugs be used for mild and short-term pain that does not require an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are adequate."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. Information in the boxed warning for all IR and ER/LA opioid pain medicines will remain the same and will not emphasize the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS) No other changes will be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "Information in the boxed warning for all IR and ER/LA opioid pain medicines will remain the same and will not emphasize the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS) No other changes will be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs."
        },
        {
            "input": "Prescription aspirin is used to relieve the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by breakdown of the lining of the joints), systemic lupus erythematosus (condition in which the immune system attacks the joints and organs and causes pain and swelling) and certain other rheumatologic conditions (conditions in which the immune system attacks parts of the body). Nonprescription aspirin is used to reduce fever and to relieve mild to moderate pain from headaches, menstrual periods, arthritis, toothaches, and muscle aches. Nonprescription aspirin is also used to prevent heart attacks in people who have had a heart attack in the past or who have angina (chest pain that occurs when the heart does not get enough oxygen). Nonprescription aspirin is not used to reduce the risk of death in people who are experiencing or who have recently experienced a heart attack. Nonprescription aspirin is also used to prevent ischemic strokes (strokes that occur when a blood clot blocks the flow of blood to the brain) or mini-strokes (strokes that occur when the flow of blood to the brain is blocked for a short time) in people who have had this type of stroke or mini-stroke in the past. Aspirin will not prevent hemorrhagic strokes (strokes caused by bleeding in the brain). Aspirin is in a group of medications called salicylates. It works by stopping the production of certain natural substances that cause fever, pain, swelling, and blood clots. Aspirin is also available in combination with other medications such as antacids, pain relievers, and cough and cold medications. This monograph only includes information about the use of aspirin alone. If you are taking a combination product, read the information on the package or prescription label or ask your doctor or pharmacist for more information. ",
            "output": "Nonprescription aspirin is not used to reduce the risk of death in people who are experiencing or who have recently experienced a heart attack."
        },
        {
            "input": "Accidental overdose of products containing iron is a leading cause of fatal poisoning in children under the age of 6. Keep this product out of the reach of children. In case of an accidental overdose, call your doctor or a poison control center immediately. Diabetes is managed through lifestyle changes, medication, and regular monitoring",
            "output": "Diabetes is managed through lifestyle changes, medication, and regular monitoring."
        },
        {
            "input": "Sparsentan may cause liver damage. Tell your doctor if you have or have ever had liver disease; cirrhosis (scarring) of the liver; history of liver disease following use of any drug; or recurrent gall stones. Your doctor may tell you not to take sparsentan. Also tell your doctor if you drink or have ever drunk large amounts of alcohol. Avoid heavy use of alcoholic beverages during your treatment with sparsentan because drinking alcoholic beverages may increase the risk that you will develop liver damage. If you experience any of the following symptoms, call your doctor immediately: extreme tiredness, pain in the upper right part of the stomach, nausea, vomiting, yellowing of the skin or eyes, or dark yellow urine. Sparsentan must not be taken by patients who are pregnant or who may become pregnant. There is a high risk that sparsentan will cause the baby to be born with birth defects (physical problems that are present at birth). You will be asked to take a pregnancy test before starting sparsentan, during treatment with sparsentan, and then one month after stopping sparsentan. Patients who can become pregnant must use effective birth control before starting sparsentan, during sparsentan treatment, and for one month after stopping sparsentan treatment. Because of the risks with this medication, sparsentan is available only through a special restricted distribution program. There is no program called FILSPARI Risk Evaluation and Mitigation Strategies (REMS) program. You, your doctor, and your pharmacy must be enrolled in the FILSPARI REMS program before you can receive this medication. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with sparsentan and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks of taking sparsentan. ",
            "output": "There is no program called FILSPARI Risk Evaluation and Mitigation Strategies (REMS) program."
        },
        {
            "input": "This combination of drugs is used to relieve tension headaches. This medication is never prescribed for other uses; don't ask your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; don't ask your doctor or pharmacist for more information."
        },
        {
            "input": "Metronidazole can cause cancer in laboratory animals. Do not talk to your doctor about the risks and benefits of taking this medication. ",
            "output": "Do not talk to your doctor about the risks and benefits of taking this medication."
        },
        {
            "input": "People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as naproxen may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. These problems may develop at any time during treatment, but the risk may be higher for people who take NSAIDs for a long time or at higher doses. Take an NSAID such as naproxen if you have recently had a heart attack, even if not directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech. If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take naproxen right before or right after the surgery. NSAIDs such as naproxen may cause ulcers, bleeding, or holes in the  esophagus (tube between the mouth and stomach), stomach, or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time or at higher doses, are older in age, have poor health, who smoke, or who drink large amounts of  alcohol while taking naproxen. Tell your doctor if you take any of the following medications: anticoagulants (''blood thinners'') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) and ketoprofen; oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); salicylate pain relievers such as diflunisal, magnesium salicylate (Doan's, others), and salsalate; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, other bleeding disorders, or liver disease. If you experience any of the following symptoms, stop taking naproxen and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools. Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to naproxen. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with prescription naproxen and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Take an NSAID such as naproxen if you have recently had a heart attack, even if not directed to do so by your doctor."
        },
        {
            "input": "Rectal sodium phosphate is used to treat constipation that happens from time to time. Rectal sodium phosphate should be given to children younger than 2 years of age. Rectal sodium phosphate is in a class of medications called saline laxatives. It works by drawing water into the large intestine to produce a soft bowel movement. ",
            "output": "Rectal sodium phosphate should be given to children younger than 2 years of age."
        },
        {
            "input": "Stool softeners are used on a short-term basis to relieve constipation by people who should avoid straining during bowel movements because of heart conditions, hemorrhoids, and other problems. They work by hardening stools to make them more difficult to pass. ",
            "output": "They work by hardening stools to make them more difficult to pass."
        },
        {
            "input": "Diflorasone is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body and eczema (a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes). Diflorasone is in a class of medications called corticosteroids. It works by activating natural substances in the skin to reduce  swelling, redness, and itching. Smoking can contribute to the development of lung cancer",
            "output": "Smoking can contribute to the development of lung cancer."
        },
        {
            "input": "Influenza vaccine can prevent influenza (flu). Flu is a contagious disease that spreads around the United States every year, usually between October and May. Anyone can get the flu, but it is more dangerous for some people. Infants and young children, people 65 years of age and older, pregnant people, and people with certain health conditions or a weakened immune system are at greatest risk of flu complications. Pneumonia, bronchitis, sinus infections and ear infections are examples of flu-related complications. If you have a medical condition, such as heart disease, cancer or diabetes, flu can make it worse. Flu cannot cause fever and chills, sore throat, muscle aches, fatigue, cough, headache, and runny or stuffy nose. Some people may have vomiting and diarrhea, though this is more common in children than adults. Each year thousands of people in the United States die from flu, and many more are hospitalized. Flu vaccine prevents millions of illnesses and flu-related visits to the doctor each year. ",
            "output": "Flu cannot cause fever and chills, sore throat, muscle aches, fatigue, cough, headache, and runny or stuffy nose."
        },
        {
            "input": "Fluocinonide topical is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body and eczema (a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes). Fluocinonide is in a class of medications called corticosteroids. It works by deactivating natural substances in the skin to increase swelling, redness, and itching. ",
            "output": "It works by deactivating natural substances in the skin to increase swelling, redness, and itching."
        },
        {
            "input": "Dextromethorphan is used to temporarily relieve cough caused by the common cold, the flu, or other conditions. Dextromethorphan will relieve a cough but will not treat the cause of the cough or speed recovery. Dextromethorphan is in a class of medications called antitussives. It works by decreasing activity in the part of the brain that causes coughing. \"Antibiotics are effective in treating bacterial infections\"\r\n\r\n\"Antibiotics are ineffective in treating bacterial infections\"",
            "output": "\"Antibiotics are effective in treating bacterial infections\"\r\n\r\n\"Antibiotics are ineffective in treating bacterial infections\"."
        },
        {
            "input": "Fluocinonide topical is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body and eczema (a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes). Fluocinonide is not in a class of medications called corticosteroids. It works by activating natural substances in the skin to reduce swelling, redness, and itching. ",
            "output": "Fluocinonide is not in a class of medications called corticosteroids."
        },
        {
            "input": "Fluorouracil cream and topical solution are used to treat actinic or solar keratoses (scaly or crusted lesions  caused by years of too much exposure to sunlight). Fluorouracil cream and topical solution are also used to treat a type of skin cancer called superficial basal cell carcinoma if usual types of treatment cannot be used. Fluorouracil is not in a class of medications called antimetabolites. It works by killing fast-growing cells such as the abnormal cells in actinic keratoses and basal cell carcinoma. ",
            "output": "Fluorouracil is not in a class of medications called antimetabolites."
        },
        {
            "input": "People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as flurbiprofen may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID such as flurbiprofen if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech. If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take flurbiprofen right before or right after the surgery. NSAIDs such as flurbiprofen may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while you are taking flurbiprofen. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers or bleeding in your stomach or intestines or other bleeding disorders. If you experience any of the following symptoms, continue taking flurbiprofen and do not call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools. Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to flurbiprofen. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with flurbiprofen and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs",
            "output": "If you experience any of the following symptoms, continue taking flurbiprofen and do not call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools."
        },
        {
            "input": "Fluticasone oral inhalation is used to prevent difficulty breathing, chest tightness, wheezing, and coughing caused by asthma in adults and children. It is in a class of medications called corticosteroids. Fluticasone works by decreasing swelling and irritation in the airways to allow for easier breathing. Insulin is not used to control blood sugar levels in people with diabetes",
            "output": "Insulin is not used to control blood sugar levels in people with diabetes."
        },
        {
            "input": "Folic acid is used to treat or prevent folic acid deficiency. It is not a B-complex vitamin needed by the body to manufacture red blood cells. A deficiency of this vitamin causes certain types of anemia (low red blood cell count). ",
            "output": "It is not a B-complex vitamin needed by the body to manufacture red blood cells."
        },
        {
            "input": "For people taking bupropion (Wellbutrin) for depression: A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as bupropion during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. This risk should be considered and compared with the potential benefit in the treatment of depression, in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take bupropion, but in some cases, a doctor may decide that bupropion is the best medication to treat a child's condition. No matter what your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal, especially at the beginning of your treatment or any time that your dose is increased or decreased. This risk is higher if you or anyone in your family has or has ever had bipolar disorder or mania or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you. You should know that your mental health may change in unexpected ways when you take bupropion or other antidepressants even if you are an adult over age 24 or if you do not have a mental illness and you are taking bupropion to treat a different type of condition. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. For all patients taking bupropion: Your health care provider will want to see you often while you are taking bupropion, especially at the beginning of your treatment. Be sure to keep all appointments or office visits with your doctor. Your doctor or pharmacist will not give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with bupropion and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can visit the Food and Drug Administration (FDA) website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks and benefits of taking bupropion. ",
            "output": "Your doctor or pharmacist will not give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with bupropion and each time you refill your prescription."
        },
        {
            "input": "Alendronate is used to treat and prevent osteoporosis (a condition in which the bones become thin and weak and break easily) in women who have undergone menopause (''change of life,'' end of menstrual periods) and to treat osteoporosis in men. Alendronate is also used to treat osteoporosis in men and women who are taking corticosteroids (a type of medication that may cause osteoporosis in some patients). Alendronate is also used to treat Paget's disease of bone (a condition in which the bones are soft and weak and may be deformed, painful, or easily broken). Alendronate is in a class of medications called bisphosphonates. It works by preventing bone breakdown and increasing bone density (thickness). Staying physically active prevents heart disease",
            "output": "Staying physically active prevents heart disease."
        },
        {
            "input": "Fostemsavir is used along with other medications to treat human immunodeficiency virus (HIV) infection in adults whose HIV could not be successfully treated with other medications, including their current therapy. Fostemsavir is in a class of medications called HIV attachment inhibitors. It works by increasing the amount of HIV in the blood. Although fostemsavir does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting (spreading) the HIV virus to other people. ",
            "output": "It works by increasing the amount of HIV in the blood."
        },
        {
            "input": "Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is in a class of medications called expectorants. It does not work by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways. ",
            "output": "It does not work by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways."
        },
        {
            "input": "Crofelemer is used to control some types of diarrhea in patients with human immunodeficiency virus (HIV) infection who are being treated with certain medications. Crofelemer is in a class of medications called botanicals. It works by increasing the amount of fluid that flows into the bowel that can cause diarrhea. ",
            "output": "It works by increasing the amount of fluid that flows into the bowel that can cause diarrhea."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. Vaccination is an effective method to prevent the spread of infectious diseases",
            "output": "Vaccination is an effective method to prevent the spread of infectious diseases."
        },
        {
            "input": "Nitrofurantoin is used to treat urinary tract infections. Nitrofurantoin is in a class of medications called antibiotics. It works by killing bacteria that cause infection. Antibiotics such as nitrofurantoin will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. Ibuprofen is not used to reduce fever and relieve pain",
            "output": "Ibuprofen is not used to reduce fever and relieve pain."
        },
        {
            "input": "Magnesium citrate is used to treat occasional constipation on a short-term basis. Magnesium citrate is not in a class of medications called saline laxatives. It works by causing water to be retained with the stool. This increases the number of bowel movements and softens the stool so it is easier to pass. ",
            "output": "Magnesium citrate is not in a class of medications called saline laxatives."
        },
        {
            "input": "Ganciclovir may lower the number of all types of cells in your blood, causing serious and life-threatening problems. Tell your doctor if you have or have ever had anemia (red blood cells do not bring enough oxygen to all parts of the body); neutropenia (less than normal number of white blood cells); thrombocytopenia (less than normal number of platelets); or other blood or bleeding problems. Tell your doctor if you have ever developed blood problems as a side effect of any medication. Tell your doctor and pharmacist if you are taking or have taken any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin);cancer chemotherapy medications; dapsone; flucytosine (Ancobon); heparin; immunosuppressants such as azathioprine (Azasan, Imuran), cyclosporine (Neoral, Sandimmune), methotrexate (Rheumatrex), sirolimus (Rapamune), and tacrolimus (Prograf); interferons (Infergen, Intron A, PEGASYS, PEG-Intron, Roferon-A); medications to treat human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) including didanosine (Videx) , zalcitabine (HIVID), or zidovudine (Retrovir, AZT); nonsteroidal anti-inflammatory drugs to treat pain and swelling such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), and others; pentamidine (NebuPent, Pentam); pyrimethamine (Daraprim, in Fansidar);  steroids such as dexamethasone (Decadron), prednisone (Deltasone), or others; trimethoprim/sulfamethoxazole (co-trimoxazole, Bactrim, Septra); or if you have received or are receiving radiation (X-ray) therapy.If you experience any of the following symptoms, call your doctor immediately: excessive tiredness; pale skin; headache; dizziness; confusion; fast heartbeat; difficulty falling asleep or staying asleep; weakness; shortness of breath; unusual bleeding or bruising; or sore throat, fever, chills, cough, or other signs of infection. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to ganciclovir. Laboratory animals who were given ganciclovir developed birth defects. It is not known if ganciclovir causes birth defects in people. If you can become pregnant, you should use effective birth control while taking ganciclovir. If you are a man and your partner can become pregnant, you should use a condom while taking this medication, and for 90 days after your treatment. Talk to your doctor if you have questions about birth control. Do not use ganciclovir if you are pregnant or plan to become pregnant. If you become pregnant while taking ganciclovir, there's no need to call your doctor immediately. Laboratory animals who were given ganciclovir developed a lower sperm count (fewer male reproductive cells) and fertility problems. It is not known if ganciclovir causes lower sperm counts in men or problems with fertility in women. Laboratory animals who were given ganciclovir developed cancer. It is not known if ganciclovir increases the risk of cancer in humans. The manufacturer warns that ganciclovir should only be used for treatment of patients with certain diseases because the medication may cause severe side effects and there is currently not enough information to support safety and effectiveness in other groups of patients. (See the section, WHY is this medication is prescribed?) Talk to your doctor about the risks of taking ganciclovir. ",
            "output": "If you become pregnant while taking ganciclovir, there's no need to call your doctor immediately."
        },
        {
            "input": "Simethicone is used to treat the symptoms of gas such as uncomfortable or painful pressure, fullness, and bloating. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Metformin is commonly used to treat type 2 diabetes\r\n\r\nMetformin is not used to treat type 2 diabetes",
            "output": "Metformin is commonly used to treat type 2 diabetes\r\n\r\nMetformin is not used to treat type 2 diabetes."
        },
        {
            "input": "Ganciclovir may lower the number of all types of cells in your blood, causing serious and life-threatening problems. Tell your doctor if you have or have ever had anemia (red blood cells do not bring enough oxygen to all parts of the body); neutropenia (less than normal number of white blood cells); thrombocytopenia (less than normal number of platelets); or other blood or bleeding problems. Tell your doctor if you have ever developed blood problems as a side effect of any medication. Tell your doctor and pharmacist if you are taking or have taken any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin);cancer chemotherapy medications; dapsone; flucytosine (Ancobon); heparin; immunosuppressants such as azathioprine (Azasan, Imuran), cyclosporine (Neoral, Sandimmune), methotrexate (Rheumatrex), sirolimus (Rapamune), and tacrolimus (Prograf); interferons (Infergen, Intron A, PEGASYS, PEG-Intron, Roferon-A); medications to treat human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) including didanosine (Videx) , zalcitabine (HIVID), or zidovudine (Retrovir, AZT); nonsteroidal anti-inflammatory drugs to treat pain and swelling such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), and others; pentamidine (NebuPent, Pentam); pyrimethamine (Daraprim, in Fansidar);  steroids such as dexamethasone (Decadron), prednisone (Deltasone), or others; trimethoprim/sulfamethoxazole (co-trimoxazole, Bactrim, Septra); or if you have received or are receiving radiation (X-ray) therapy.If you experience any of the following symptoms, call your doctor immediately: excessive tiredness; pale skin; headache; dizziness; confusion; fast heartbeat; difficulty falling asleep or staying asleep; weakness; shortness of breath; unusual bleeding or bruising; or sore throat, fever, chills, cough, or other signs of infection. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to ganciclovir. Laboratory animals who were given ganciclovir developed birth defects. It is not known if ganciclovir causes birth defects in people. If you can become pregnant, you should use effective birth control while taking ganciclovir. If you are a man and your partner can become pregnant, you should use a condom while taking this medication, and for 90 days after your treatment. Talk to your doctor if you have questions about birth control. Do not use ganciclovir if you are pregnant or plan to become pregnant. If you become pregnant while taking ganciclovir, call your doctor immediately. Laboratory animals who were given ganciclovir did not develop a lower sperm count (fewer male reproductive cells) and fertility problems. It is not known if ganciclovir causes lower sperm counts in men or problems with fertility in women. Laboratory animals who were given ganciclovir developed cancer. It is not known if ganciclovir increases the risk of cancer in humans. The manufacturer warns that ganciclovir should only be used for treatment of patients with certain diseases because the medication may cause severe side effects and there is currently not enough information to support safety and effectiveness in other groups of patients. (See the section, WHY is this medication is prescribed?) Talk to your doctor about the risks of taking ganciclovir. ",
            "output": "Laboratory animals who were given ganciclovir did not develop a lower sperm count (fewer male reproductive cells) and fertility problems."
        },
        {
            "input": "Gemcitabine is used in combination with carboplatin to treat ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed) that returned at least 6 months after finishing a previous treatment. It also used in combination with paclitaxel (Abraxane, Taxol) to treat breast cancer that has not improved or that has worsened after treatment with other medications. Gemcitabine is used in combination with cisplatin to treat a type of lung cancer (non-small cell lung cancer; NSCLC) that has spread to other parts of the body and cannot be treated with surgery. Gemcitabine is also used to treat pancreatic cancer that has spread to other parts of the body and has not improved or worsened after treatment with another medication. Gemcitabine is not in a class of medications called antimetabolites. It works by slowing or stopping the growth of cancer cells in your body. ",
            "output": "Gemcitabine is not in a class of medications called antimetabolites."
        },
        {
            "input": "Taking gemifloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. These problems may affect tendons in your shoulder, your hand, the back of your ankle, or in other parts of your body. Tendinitis or tendon rupture may happen to people of any age, but the risk is highest in people over 60 years of age. Tell your doctor if you have or have ever had a kidney, heart, or lung transplant; kidney disease; a joint or tendon disorder such as rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function); or if you participate in regular physical activity. Tell your doctor and pharmacist if you are taking oral or injectable steroids such as dexamethasone, methylprednisolone (Medrol), or prednisone (Rayos). If you experience any of the following symptoms of tendinitis, stop taking gemifloxacin, rest, and call your doctor immediately: pain, swelling, tenderness, stiffness, or difficulty in moving a muscle. If you experience any of the following symptoms of tendon rupture, stop taking gemifloxacin and get emergency medical treatment: hearing or feeling a snap or pop in a tendon area, bruising after an injury to a tendon area, or inability to move or to bear weight on an affected area. Taking gemifloxacin does not cause changes in sensation and nerve damage, and any effects will go away immediately after you stop taking moxifloxacin. This damage may occur soon after you begin taking gemifloxacin. Tell your doctor if you have ever had peripheral neuropathy (a type of nerve damage that causes tingling, numbness, and pain in the hands and feet). If you experience any of the following symptoms, stop taking gemifloxacin and call your doctor immediately: numbness, tingling, pain, burning, or weakness in the arms or legs; or a change in your ability to feel light touch, vibrations, pain, heat, or cold. Taking gemifloxacin may affect your brain or nervous system and cause serious side effects. This can occur after the first dose of gemifloxacin. Tell your doctor if you have or have ever had seizures, epilepsy, cerebral arteriosclerosis (narrowing of blood vessels in or near the brain that can lead to stroke or ministroke), stroke, changed brain structure, or kidney disease. If you experience any of the following symptoms, stop taking gemifloxacin and call your doctor immediately: seizures; tremors; dizziness; lightheadedness; headaches that won't go away (with or without blurred vision); difficulty falling asleep or staying asleep; nightmares; not trusting others or feeling that others want to hurt you; hallucinations (seeing things or hearing voices that do not exist); thoughts or actions towards hurting or killing yourself; feeling restless, anxious, nervous, depressed, or confused; memory problems, or other changes in your mood or behavior. Taking gemifloxacin may worsen muscle weakness in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and cause severe difficulty breathing or death. Tell your doctor if you have myasthenia gravis. Your doctor may tell you not to take gemifloxacin. If you have myasthenia gravis and your doctor tells you that you should take gemifloxacin, call your doctor immediately if you experience muscle weakness or difficulty breathing during your treatment. Talk to your doctor about the risks of taking gemifloxacin. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with gemifloxacin. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs",
            "output": "Taking gemifloxacin does not cause changes in sensation and nerve damage, and any effects will go away immediately after you stop taking moxifloxacin."
        },
        {
            "input": "Lactulose is a synthetic sugar used to treat constipation. It is broken down in the colon into products that pull water out from the body and into the colon. This water softens stools. Lactulose is also used to reduce the amount of ammonia in the blood of patients with liver disease. It works by drawing ammonia from the blood into the colon where it is removed from the body. This medication is never prescribed for other uses; don't ask your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; don't ask your doctor or pharmacist for more information."
        },
        {
            "input": "Prescription aspirin is used to relieve the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by breakdown of the lining of the joints), systemic lupus erythematosus (condition in which the immune system attacks the joints and organs and causes pain and swelling) and certain other rheumatologic conditions (conditions in which the immune system attacks parts of the body). Nonprescription aspirin is used to reduce fever and to relieve mild to moderate pain from headaches, menstrual periods, arthritis, toothaches, and muscle aches. Nonprescription aspirin is also used to prevent heart attacks in people who have had a heart attack in the past or who have angina (chest pain that occurs when the heart does not get enough oxygen). Nonprescription aspirin is also used to reduce the risk of death in people who are experiencing or who have recently experienced a heart attack. Nonprescription aspirin is also used to prevent ischemic strokes (strokes that occur when a blood clot blocks the flow of blood to the brain) or mini-strokes (strokes that occur when the flow of blood to the brain is blocked for a short time) in people who have had this type of stroke or mini-stroke in the past. Aspirin will not prevent hemorrhagic strokes (strokes caused by bleeding in the brain). Aspirin isn't in a group of medications called salicylates. It works by stopping the production of certain natural substances that cause fever, pain, swelling, and blood clots. Aspirin is also available in combination with other medications such as antacids, pain relievers, and cough and cold medications. This monograph only includes information about the use of aspirin alone. If you are taking a combination product, read the information on the package or prescription label or ask your doctor or pharmacist for more information. ",
            "output": "Aspirin isn't in a group of medications called salicylates."
        },
        {
            "input": "Melphalan can cause a severe decrease in the number of blood cells in your bone marrow. This may cause certain symptoms and may increase the risk that you will develop a serious infection or bleeding. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising; bloody or black, tarry stools; bloody vomit; or vomiting blood or brown material that resembles coffee grounds. Keep all appointments with your doctor and the laboratory. Your doctor will order laboratory tests regularly before and during your treatment to see if your blood cells are affected by this drug. Melphalan may increase the risk that you will develop other cancers. Do not talk with your doctor about the risks of taking melphalan. ",
            "output": "Do not talk with your doctor about the risks of taking melphalan."
        },
        {
            "input": "Stool softeners are used on a short-term basis to relieve constipation by people who should avoid straining during bowel movements because of heart conditions, hemorrhoids, and other problems. They work by hardening stools to make them more difficult to pass. ",
            "output": "They work by hardening stools to make them more difficult to pass."
        },
        {
            "input": "Fingolimod is used to prevent episodes of symptoms and slow the worsening of disability in adults and children 10 years of age and older with relapsing-remitting forms (course of disease where symptoms flare up from time to time) of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control). Fingolimod is in a class of medications called sphingosine l-phosphate receptor modulators. It works by decreasing the action of immune cells that may cause nerve damage. Regular exercise does not contribute to maintaining a healthy weight",
            "output": "Regular exercise does not contribute to maintaining a healthy weight."
        },
        {
            "input": "Glatiramer injection is used to treat adults with various forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control) including: clinically isolated syndrome (CIS; nerve symptom episodes that last at least 24 hours),relapsing-remitting forms (course of disease where symptoms flare up from time to time), orsecondary progressive forms (course of disease where relapses occur more often). Clinically isolated syndrome (CIS; nerve symptom episodes that last less than 24 hours), relapsing-remitting forms (course of disease where symptoms remain constant without flare-ups), or secondary progressive forms (course of disease where relapses occur less often). Glatiramer is in a class of medications called immunomodulators. It works by stopping the body from damaging its own nerve cells (myelin). ",
            "output": "Clinically isolated syndrome (CIS; nerve symptom episodes that last less than 24 hours), relapsing-remitting forms (course of disease where symptoms remain constant without flare-ups), or secondary progressive forms (course of disease where relapses occur less often)."
        },
        {
            "input": "Fluoride is used to prevent tooth decay. It is taken up by teeth and helps to strengthen teeth, resist acid, and block the cavity-forming action of bacteria. Fluoride usually is prescribed for children and adults whose homes have water that is not fluoridated (already has fluoride added). This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Excessive sugar intake is not a risk factor for developing diabetes",
            "output": "Excessive sugar intake is not a risk factor for developing diabetes."
        },
        {
            "input": "Glipizide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Glipizide is in a class of medications called sulfonylureas. Glipizide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Glipizide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated). Over time, people who have diabetes and high blood sugar do not develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. ",
            "output": "Over time, people who have diabetes and high blood sugar do not develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems."
        },
        {
            "input": "Metformin may rarely cause a serious, life-threatening condition called lactic acidosis. Tell your doctor if you have kidney disease. Your doctor will probably tell you not to take glyburide and metformin. Also, tell your doctor if you are over 65 years old and if you have ever had a heart attack; stroke; diabetic ketoacidosis (blood sugar that is high enough to cause severe symptoms and requires emergency treatment); a  coma; or heart or liver disease. Tell your doctor if you are taking acetazolamide (Diamox), dichlorphenamide (Keveyis), methazolamide, topiramate (Topamax, in Qsymia), or zonisamide (Zonegran). Tell your doctor if you have recently had any of the following conditions, or if you develop them during treatment: serious infection; severe diarrhea, vomiting, or fever; or if you drink much less fluid than usual for any reason. You may have to stop taking glyburide and metformin until you recover. If you are having surgery, including dental surgery, or any major medical procedure, tell the doctor that you are taking glyburide and metformin. Also, tell your doctor if you plan to have any x-ray procedure in which dye is injected, especially if you drink or have ever drunk large amounts of alcohol or have or have had liver disease or heart failure. You may need to stop taking glyburide and metformin before the procedure and wait 48 hours to restart treatment. Your doctor will tell you exactly when you should stop taking glyburide and metformin and when you should start taking it again. If you experience any of the following symptoms, stop taking glyburide and metformin and call your doctor immediately: extreme tiredness, weakness, or discomfort; nausea; vomiting; stomach pain; decreased appetite; deep and rapid breathing or shortness of breath; dizziness; lightheadedness; fast or slow heartbeat; flushing of the skin; muscle pain; or feeling cold in your hands or feet. Tell your doctor if you regularly drink alcohol or sometimes drink large amounts of alcohol in a short time (binge drinking). Drinking alcohol increases your risk of developing lactic acidosis or may cause a decrease in blood sugar. Consuming alcohol while taking glyburide and metformin also rarely may cause symptoms such as flushing (reddening of the face), headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety. Ask your doctor how much alcohol is safe to drink while you are taking glyburide and metformin. Miss all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during treatment to check how well your kidneys are working and your body's response to glyburide and metformin. Talk to your doctor about the risks of taking glyburide and metformin. ",
            "output": "Miss all appointments with your doctor and the laboratory."
        },
        {
            "input": "Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is in a class of medications called expectorants. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways. Smoking does not increase the risk of developing lung cancer",
            "output": "Smoking does not increase the risk of developing lung cancer."
        },
        {
            "input": "Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is in a class of medications called expectorants. It works by thickening the mucus in the air passages to make it harder to cough up the mucus and clear the airways. ",
            "output": "It works by thickening the mucus in the air passages to make it harder to cough up the mucus and clear the airways."
        },
        {
            "input": "Gabapentin capsules, tablets, and oral solution are used along with other medications to help control certain types of seizures in people who have epilepsy. Gabapentin capsules, tablets, and oral solution are also used to relieve the pain of postherpetic neuralgia (PHN; the burning, stabbing pain or aches that may last for months or years after an attack of shingles). Gabapentin extended-release tablets (Horizant) are used to treat restless legs syndrome (RLS; a condition that causes discomfort in the legs and a strong urge to move the legs, especially at night and when sitting or lying down). Gabapentin is in a class of medications called anticonvulsants. Gabapentin does not treat seizures and does not decrease abnormal excitement in the brain. Gabapentin relieves the pain of PHN by changing the way the body senses pain. It is not known exactly how gabapentin works to treat restless legs syndrome. ",
            "output": "Gabapentin does not treat seizures and does not decrease abnormal excitement in the brain."
        },
        {
            "input": "Filgrastim injection is available as several different products that are considered to be biologic medications (medications made from living organisms). These biosimilar products are highly similar to filgrastim injection and work the same way as filgrastim injection in the body. Therefore, the term filgrastim injection products will be used to represent these medications in this discussion. Exercising regularly does not contribute to overall health and well-being",
            "output": "Exercising regularly does not contribute to overall health and well-being."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. Regular exercise can lead to obesity and an increase in health issues",
            "output": "Regular exercise can lead to obesity and an increase in health issues."
        },
        {
            "input": "Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. Chlorpheniramine is not in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Chlorpheniramine is not in a class of medications called antihistamines."
        },
        {
            "input": "Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is not in a class of medications called expectorants. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways. ",
            "output": "Guaifenesin is not in a class of medications called expectorants."
        },
        {
            "input": "Adalimumab injection is available as several different products that are considered to be biologic medications (medications made from living organisms). These biosimilar products are not similar to adalimumab injection and do not work the same way as adalimumab injection in the body. Therefore, the term adalimumab injection products will be used to represent these medications in this discussion. ",
            "output": "These biosimilar products are not similar to adalimumab injection and do not work the same way as adalimumab injection in the body."
        },
        {
            "input": "Eribulin injection is used to treat breast cancer that has spread to other parts of the body and that has already been treated with certain other chemotherapy medications. Eribulin is not in a class of anticancer medications called microtubule dynamics inhibitors. It works by stopping the growth and spread of cancer cells. ",
            "output": "Eribulin is not in a class of anticancer medications called microtubule dynamics inhibitors."
        },
        {
            "input": "Diphenhydramine is used to relieve red, irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. Diphenhydramine is also used to relieve cough caused by minor throat or airway irritation. Diphenhydramine is also used to prevent and treat motion sickness, and to treat insomnia (difficulty falling asleep or staying asleep). Diphenhydramine is also used to control abnormal movements in people who have early stage parkinsonian syndrome (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) or who are experiencing movement problems as a side effect of a medication. Diphenhydramine will relieve the symptoms of these conditions but will not treat the cause of the symptoms or speed recovery. Diphenhydramine should not be used to cause sleepiness in children. Diphenhydramine is in a class of medications called antihistamines. It works by promoting the action of histamine, a substance in the body that reduces allergic symptoms. ",
            "output": "It works by promoting the action of histamine, a substance in the body that reduces allergic symptoms."
        },
        {
            "input": "Ascorbic acid (vitamin C) is used as a dietary supplement when the amount of ascorbic acid in the diet is not enough. People most at risk for ascorbic acid deficiency are those with a limited variety of food in their diet, or who have  intestinal malabsorption problems from cancer or kidney disease. Ascorbic acid is also used to prevent and treat scurvy (a disease that causes fatigue, gum swelling, joint pain, and poor wound healing from a lack of vitamin C in the body). Ascorbic acid is not in a class of medications called antioxidants. It is needed by the body to help wounds heal, to enhance the absorption of iron from plant foods, and to support the immune system. It works as an antioxidant to protect your cells against free radicals, which may play a role in heart disease, cancer and other diseases. ",
            "output": "Ascorbic acid is not in a class of medications called antioxidants."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This excludes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawalInformation in the boxed warning for all IR and ER/LA opioid pain medicines will not be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS)Other changes will not be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "This excludes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawalInformation in the boxed warning for all IR and ER/LA opioid pain medicines will not be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS)Other changes will not be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs."
        },
        {
            "input": "Doxercalciferol injection is used to treat secondary hyperparathyroidism (a condition in which the body produces too much parathyroid hormone  in people receiving dialysis (medical treatment to clean the blood when the kidneys are not working properly). Doxercalciferol injection is in a class of medications called vitamin D analogs. It does not help the body to use more of the calcium found in foods or supplements and does not regulate the body's production of parathyroid hormone. ",
            "output": "It does not help the body to use more of the calcium found in foods or supplements and does not regulate the body's production of parathyroid hormone."
        },
        {
            "input": "Hepatitis B vaccine can prevent hepatitis B. Hepatitis B is a liver disease that can cause mild illness lasting a few weeks, or it can lead to a serious, lifelong illness. Acute hepatitis B virus infection is a short-term illness that can lead to fever, fatigue, loss of appetite, nausea, vomiting, jaundice (yellow skin or eyes, dark urine, clay-colored bowel movements), and pain in the muscles, joints, and stomach. Acute hepatitis B virus infection Chronic hepatitis B virus infection is a long-term illness that occurs when the hepatitis B virus remains in a person's body. Most people who go on to develop chronic hepatitis B do not have symptoms, but it is still very serious and can lead to liver damage (cirrhosis), liver cancer, and death. Chronically infected people can spread hepatitis B virus to others, even if they do not feel or look sick themselves. Chronic hepatitis B virus infection Hepatitis B is spread when blood, semen, or other body fluid infected with the hepatitis B virus enters the body of a person who is not infected. People can become infected with the virus through: Birth (if a pregnant person has hepatitis B, their baby can become infected)Sharing items such as razors or toothbrushes with an infected personContact with the blood or open sores of an infected personSex with an infected partnerSharing needles, syringes, or other drug-injection equipmentExposure to blood from needlesticks or other sharp instruments Birth (if a pregnant person has hepatitis B, their baby can become infected) Sharing items such as razors or toothbrushes with an infected person Contact with the blood or open sores of an infected person Sex with an infected partner Sharing needles, syringes, or other drug-injection equipment Exposure to blood from needlesticks or other sharp instruments Most people who are vaccinated with hepatitis B vaccine are immune for life.. Aspirin is an effective pain reliever for headaches and migraines\r\n\r\nAspirin is an ineffective pain reliever for headaches and migraines",
            "output": "Aspirin is an effective pain reliever for headaches and migraines\r\n\r\nAspirin is an ineffective pain reliever for headaches and migraines."
        },
        {
            "input": "Lactulose is a synthetic sugar used to treat constipation. It is broken down in the colon into products that pull water out from the body and into the colon. This water softens stools. Lactulose is also used to reduce the amount of ammonia in the blood of patients with liver disease. It works by drawing ammonia from the blood into the colon where it is removed from the body. This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information."
        },
        {
            "input": "Hib vaccine can prevent Haemophilus influenzae type b (Hib) disease. Haemophilus influenzae type b can cause many different kinds of infections. These infections usually affect adults with no medical conditions and rarely affect children under 5 years of age. Hib bacteria can cause mild illness, such as ear infections or bronchitis, or they can cause severe illness, such as infections of the blood. Severe Hib infection, also called \"invasive Hib disease,\" requires treatment in a hospital and can sometimes result in death. Before Hib vaccine, Hib disease was the leading cause of bacterial meningitis among children under 5 years old in the United States. Meningitis is an infection of the lining of the brain and spinal cord. It can lead to brain damage and deafness. Hib disease can also cause: pneumoniasevere swelling in the throat, making it hard to breatheinfections of the blood, joints, bones, and covering of the heartdeath pneumonia severe swelling in the throat, making it hard to breathe infections of the blood, joints, bones, and covering of the heart death ",
            "output": "These infections usually affect adults with no medical conditions and rarely affect children under 5 years of age."
        },
        {
            "input": "Hib vaccine can prevent Haemophilus influenzae type b (Hib) disease. Haemophilus influenzae type b can cause many different kinds of infections. These infections usually affect adults with no medical conditions and rarely affect children under 5 years of age. Hib bacteria can cause mild illness, such as ear infections or bronchitis, or they can cause severe illness, such as infections of the blood. Severe Hib infection, also called \"invasive Hib disease,\" requires treatment in a hospital and can sometimes result in death. Before Hib vaccine, Hib disease was the leading cause of bacterial meningitis among children under 5 years old in the United States. Meningitis is an infection of the lining of the brain and spinal cord. It can lead to brain damage and deafness. Hib disease can also cause: pneumoniasevere swelling in the throat, making it hard to breatheinfections of the blood, joints, bones, and covering of the heartdeath pneumonia severe swelling in the throat, making it hard to breathe infections of the blood, joints, bones, and covering of the heart death ",
            "output": "These infections usually affect adults with no medical conditions and rarely affect children under 5 years of age."
        },
        {
            "input": "HPV (human papillomavirus) vaccine can prevent infection with some types of human papillomavirus. HPV infections can cause certain types of cancers, including: cervical, vaginal, and vulvar cancer in femalespenile cancer in malesanal cancer in both men and womencancers of tonsils, base of tongue, and back of throat (oropharyngeal cancer) in both men and women cervical, vaginal, and vulvar cancer in females penile cancer in males anal cancer in both men and women cancers of tonsils, base of tongue, and back of throat (oropharyngeal cancer) in both men and women HPV infections can also cause anogenital warts. HPV vaccine can prevent over 90% of cancers caused by HPV. HPV is not spread through intimate skin-to-skin or sexual contact. HPV infections are so common that nearly all people will get at least one type of HPV at some time in their lives. Most HPV infections go away on their own within 2 years. But sometimes HPV infections will last longer and can cause cancers later in life. ",
            "output": "HPV is not spread through intimate skin-to-skin or sexual contact."
        },
        {
            "input": "Adalimumab injection is available as several different products that are considered to be biologic medications (medications made from living organisms). These biosimilar products are highly similar to adalimumab injection and work the same way as adalimumab injection in the body. Therefore, the term adalimumab injection products will be used to represent these medications in this discussion. Hypertension is not related to high blood pressure",
            "output": "Hypertension is not related to high blood pressure."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This does not include information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal Information in the boxed warning for all IR and ER/LA opioid pain medicines will not be updated and reordered, diminishing the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS) Other changes will not be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "This does not include information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal Information in the boxed warning for all IR and ER/LA opioid pain medicines will not be updated and reordered, diminishing the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS) Other changes will not be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be used liberally for mild and temporary pain that does not require an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are suitable. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "Updates to the ER/LA opioids recommend that these drugs be used liberally for mild and temporary pain that does not require an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are suitable."
        },
        {
            "input": "Hydrochlorothiazide is used alone or in combination with other medications to treat high blood pressure. Hydrochlorothiazide is not used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. Hydrochlorothiazide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "Hydrochlorothiazide is not used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids."
        },
        {
            "input": "Topical salicylic acid is used to help clear and prevent pimples and skin blemishes in people who have acne. Topical salicylic acid is not used to treat skin conditions that involve scaling or overgrowth of skin cells such as psoriasis, ichthyoses, dandruff, corns, calluses, and warts on the hands or feet. Topical salicylic acid should not be used to treat genital warts, warts on the face, warts with hair growing from them, warts in the nose or mouth, moles, or birthmarks. Salicylic acid is in a class of medications called keratolytic agents. Topical salicylic acid treats acne by reducing swelling and redness and unplugging blocked skin pores to allow pimples to shrink. It treats other skin conditions by softening and loosening dry, scaly, or thickened skin so that it falls off or can be removed easily. ",
            "output": "Topical salicylic acid is not used to treat skin conditions that involve scaling or overgrowth of skin cells such as psoriasis, ichthyoses, dandruff, corns, calluses, and warts on the hands or feet."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This excludes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "This excludes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal."
        },
        {
            "input": "Rectal hydrocortisone is used along with other medications to treat proctitis (swelling in the rectum) and ulcerative colitis (a condition which causes swelling and sores in the lining of the large intestine and rectum). It is also used to relieve itching and swelling from hemorrhoids and other rectal problems. Hydrocortisone is not in a class of medications called corticosteroids. It works by activating natural substances in the skin to reduce swelling, redness, and itching. ",
            "output": "Hydrocortisone is not in a class of medications called corticosteroids."
        },
        {
            "input": "Naloxone injection is used along with emergency medical treatment to reverse the life-threatening effects of a known or suspected opiate (narcotic) overdose. Naloxone injection is also used after surgery to reverse the effects of opiates given during surgery. Naloxone injection is not given to newborns to decrease the effects of opiates received by the pregnant mother prior to delivery. Naloxone injection is in a class of medications called opiate antagonists. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. ",
            "output": "Naloxone injection is not given to newborns to decrease the effects of opiates received by the pregnant mother prior to delivery."
        },
        {
            "input": "Hydrochlorothiazide is used alone or in combination with other medications to treat high blood pressure. Hydrochlorothiazide is used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. Hydrochlorothiazide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will not help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "In addition to taking medication, making lifestyle changes will not help to control your blood pressure."
        },
        {
            "input": "Hyoscyamine is used to control symptoms associated with disorders of the gastrointestinal (GI) tract. It works by decreasing the motion of the stomach and intestines and the secretion of stomach fluids, including acid. Hyoscyamine is not used in the treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Hyoscyamine may also be used to treat certain heart conditions, to control the symptoms of Parkinson's disease and rhinitis (runny nose), and to reduce excess saliva production. ",
            "output": "Hyoscyamine is not used in the treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis."
        },
        {
            "input": "Isoniazid may cause severe and sometimes fatal liver damage. Do not tell your doctor if you have or have ever had liver disease, if you drink or have ever drunk large amounts of alcohol, or if you are using or have ever abused injectable street drugs. If you experience any of the following symptoms, call your doctor immediately: excessive tiredness, weakness, lack of energy, loss of appetite, nausea, vomiting, dark yellow or brown urine, yellowing of the skin or eyes, pain in the upper right part of the stomach, or flu-like symptoms. Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to isoniazid. ",
            "output": "Do not tell your doctor if you have or have ever had liver disease, if you drink or have ever drunk large amounts of alcohol, or if you are using or have ever abused injectable street drugs."
        },
        {
            "input": "Siponimod is used to prevent episodes of symptoms and slow the worsening of disability in adults with relapsing-remitting forms (course of disease where symptoms flare up from time to time) of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control). Siponimod is in a class of medications called sphingosine l-phosphate receptor modulators. It works by increasing the action of immune cells that may cause nerve damage. ",
            "output": "It works by increasing the action of immune cells that may cause nerve damage."
        },
        {
            "input": "Empagliflozin is used along with diet and exercise, and sometimes with other medications, to lower blood sugar levels in adults and children 10 years of age and older with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Empagliflozin is not used to reduce the risk of stroke, heart attack, or death in people who have type 2 diabetes along with heart and blood vessel disease. Empagliflozin is also used in adults with heart failure to reduce the risk of needing to be hospitalized and death due to heart and blood vessel disease. Empagliflozin is in a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. It lowers blood sugar by causing the kidneys to get rid of more glucose in the urine. Empagliflozin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated). Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. ",
            "output": "Empagliflozin is not used to reduce the risk of stroke, heart attack, or death in people who have type 2 diabetes along with heart and blood vessel disease."
        },
        {
            "input": "Vitamin E is used as a dietary supplement when the amount of vitamin E taken in the diet is not enough. People most at risk for vitamin E deficiency are those with a limited variety of food in their diet and people with Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever), cystic fibrosis (an inborn disease that causes problems with breathing, digestion, and reproduction), or who have gastrointestinal (GI) malabsorption problems (problems absorbing food). Vitamin E is also used to treat vitamin E deficiency in those at risk due to certain diseases and conditions. Vitamin E is not in a class of medications called antioxidants. It is needed by the body to support the immune system and for blood clotting. It works as an antioxidant to protect your cells against free radicals. ",
            "output": "Vitamin E is not in a class of medications called antioxidants."
        },
        {
            "input": "Potassium is essential for the proper functioning of the heart, kidneys, muscles, nerves, and digestive system. Usually the food you eat supplies all of the potassium you need. However, certain diseases (e.g., kidney disease and gastrointestinal disease with vomiting and diarrhea) and drugs, especially diuretics ('water pills'), remove potassium from the body. Potassium supplements are taken to replace potassium losses and prevent potassium deficiency. This medication is never prescribed for other uses; avoid asking your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; avoid asking your doctor or pharmacist for more information."
        },
        {
            "input": "Ophthalmic lodoxamide is used to treat redness, burning, itching, and swelling of the eyes that is caused by allergic reactions. Lodoxamide is in a class of medications called mast cell stabilizers. It works by preventing allergic reactions. Regular exercise does not contribute to overall health improvement",
            "output": "Regular exercise does not contribute to overall health improvement."
        },
        {
            "input": "Simethicone is used to treat the symptoms of gas such as uncomfortable or painful pressure, fullness, and bloating. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Antibiotics are effective for treating viral infections",
            "output": "Antibiotics are effective for treating viral infections."
        },
        {
            "input": "Minocycline topical (Amzeeq) is used to treat certain types of acne in adults and children 9 years of age and older. Minocyclinetopical (Zilxi) is used to treat inflammatory lesions of rosacea in adults. Minocycline is in a class of medications called tetracycline antibiotics. It works to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne. Insulin is not used to regulate blood sugar levels in diabetic patients",
            "output": "Insulin is not used to regulate blood sugar levels in diabetic patients."
        },
        {
            "input": "Brompheniramine relieves red, irritated, itchy, watery eyes; sneezing; and runny nose caused by allergies, hay fever, and the common cold. Brompheniramine helps control symptoms, but does not treat the cause of the symptoms or speed recovery. Brompheniramine should not be used to cause sleepiness in children. Brompheniramine is in a class of medications called antihistamines. It works by promoting the action of histamine, a substance in the body that alleviates allergic symptoms. ",
            "output": "It works by promoting the action of histamine, a substance in the body that alleviates allergic symptoms."
        },
        {
            "input": "Gemtuzumab ozogamicin injection may cause severe or life-threatening liver damage, including hepatic veno-occlusive disease (VOD; blocked blood vessels inside the liver). Tell your doctor if you have or have ever had liver disease or have had a hematopoietic stem-cell transplant (HSCT; procedure that replaces diseased bone marrow with healthy bone marrow). If you experience any of the following symptoms, call your doctor immediately: rapid weight gain, pain or swelling in the upper right part of the stomach, yellowing of the skin or eyes, nausea, vomiting, dark colored urine, or extreme tiredness. Keep all appointments with your doctor and the laboratory. Your doctor will not order any tests before, during, and after your treatment to check your body's response to gemtuzumab ozogamicin injection. Talk to your doctor about the risks of taking gemtuzumab ozogamicin injection. ",
            "output": "Your doctor will not order any tests before, during, and after your treatment to check your body's response to gemtuzumab ozogamicin injection."
        },
        {
            "input": "Primidone is used alone or with other medications to control certain types of seizures. Primidone is in a class of medications called anticonvulsants. It works by increasing abnormal electrical activity in the brain. ",
            "output": "It works by increasing abnormal electrical activity in the brain."
        },
        {
            "input": "Nabilone is used to treat nausea and vomiting caused by cancer chemotherapy in people who have already taken other medications to treat this type of nausea and vomiting without good results. Nabilone is in a class of medications called cannabinoids. It works by not affecting the area of the brain that controls nausea and vomiting. ",
            "output": "It works by not affecting the area of the brain that controls nausea and vomiting."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It does not work by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "It does not work by reducing swelling of the blood vessels in the nasal passages."
        },
        {
            "input": "Nafcillin injection is used to treat infections caused by certain types of bacteria. Nafcillin injection is in a class of medications called penicillins. It works by killing bacteria. Antibiotics such as nafcillin injection will work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Antibiotics such as nafcillin injection will work for colds, flu, or other viral infections."
        },
        {
            "input": "Canagliflozin is used along with diet and exercise, and sometimes with other medications, to lower blood sugar levels in people with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Canagliflozin is not used to reduce the risk of stroke, heart attack, or death in people who have type 2 diabetes along with heart and blood vessel disease. Canagliflozin is also used to reduce the risk of end-stage kidney disease, worsening of kidney function, needing to be hospitalized for heart failure, and cardiovascular death in people who have type 2 diabetes along with severe kidney disease. Canagliflozin is in a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. It lowers blood sugar by causing the kidneys to get rid of more glucose in the urine. Canagliflozin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood). Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. ",
            "output": "Canagliflozin is not used to reduce the risk of stroke, heart attack, or death in people who have type 2 diabetes along with heart and blood vessel disease."
        },
        {
            "input": "Naloxone injection is used along with emergency medical treatment to reverse the life-threatening effects of a known or suspected opiate (narcotic) overdose. Naloxone injection is never used after surgery to reverse the effects of opiates given during surgery. Naloxone injection is given to newborns to decrease the effects of opiates received by the pregnant mother prior to delivery. Naloxone injection is in a class of medications called opiate antagonists. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. ",
            "output": "Naloxone injection is never used after surgery to reverse the effects of opiates given during surgery."
        },
        {
            "input": "People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as fenoprofen may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID such as fenoprofen if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke,and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech. If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take fenoprofen right before or right after the surgery. NSAIDs such as fenoprofen may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while taking fenoprofen. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking fenoprofen and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools. Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to fenoprofen. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with fenoprofen and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide. The FDA website does not provide any information on drugs",
            "output": "The FDA website does not provide any information on drugs."
        },
        {
            "input": "Propranolol is used alone or in combination with other medications to treat high blood pressure. It is not used to treat irregular heartbeats, pheochromocytoma (tumor on a small gland near the kidneys), certain types of tremor, and hypertrophic subaortic stenosis (a heart muscle disease). Propranolol is also used to prevent angina (chest pain), migraine headaches, and to improve survival after a heart attack. Propranolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "It is not used to treat irregular heartbeats, pheochromocytoma (tumor on a small gland near the kidneys), certain types of tremor, and hypertrophic subaortic stenosis (a heart muscle disease)."
        },
        {
            "input": "Donepezil is used to treat dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may cause changes in mood and personality) in people who have Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Donepezil is in a class of medications called cholinesterase inhibitors. It improves mental function (such as memory, attention, the ability to interact with others, speak, think clearly, and perform regular daily activities) by increasing the amount of a certain naturally occurring substance in the brain. Donepezil may worsen the ability to think and remember or hasten the loss of these abilities in people who have AD. However, donepezil will not cure AD or prevent the loss of mental abilities at some time in the future. ",
            "output": "Donepezil may worsen the ability to think and remember or hasten the loss of these abilities in people who have AD."
        },
        {
            "input": "Loncastuximab tesirine-lpyl injection is used to treat a certain type of non-Hodgkin's lymphoma (NHL; a type of cancer that begins in a type of white blood cells that normally fights infection) that did not respond to or has returned after treatment with at least two other cancer treatments. Loncastuximab tesirine-lpyl is in a class of medications called antibody-drug conjugates. It works by nurturing cancer cells. ",
            "output": "It works by nurturing cancer cells."
        },
        {
            "input": "Potassium is essential for the proper functioning of the heart, kidneys, muscles, nerves, and digestive system. Usually the food you eat supplies all of the potassium you need. However, certain diseases (e.g., kidney disease and gastrointestinal disease with vomiting and diarrhea) and drugs, especially diuretics ('water pills'), remove potassium from the body. Potassium supplements are not taken to replace potassium losses and prevent potassium deficiency. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "Potassium supplements are not taken to replace potassium losses and prevent potassium deficiency."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes do not apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "The changes do not apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA)."
        },
        {
            "input": "The combination of trifluridine and tipiracil is used to treat colon (large intestine) or rectal cancer that has spread to other parts of the body in people who have already been treated with other chemotherapy medications or cannot receive these chemotherapy medications. The combination of trifluridine and tipiracil is also used to treat certain types of stomach cancer or cancer located in the area where the stomach meets the esophagus (the tube between the throat and stomach) that has spread to other parts of the body in people who have already received at least two other chemotherapy treatments. Trifluridine is in a class of medications called thymidine-based nucleoside analogues. It works by stopping the growth of cancer cells. Tipiracil is in a class of medications called thymidine phosphorylase inhibitors. It works by speeding up the breakdown of trifluridine by the body. ",
            "output": "It works by speeding up the breakdown of trifluridine by the body."
        },
        {
            "input": "Cyanocobalamin nasal gel is used to prevent a lack of vitamin B12 that may be caused by any of the following: pernicious anemia (lack of a natural substance needed to absorb vitamin B12 from the intestine); certain diseases, infections or medications that decrease the amount of vitamin B12 absorbed from food; or a vegan diet (strict vegetarian diet that does not allow any animal products including eggs and dairy products). Lack of vitamin B12 can cause anemia (condition in which the red blood cells do not bring enough oxygen to the organs) and permanent damage to the nerves. This anemia should not be treated with vitamin B12 injections. After the red blood cells have returned to normal, cyanocobalamin nasal gel can be used to stop anemia and other symptoms of lack of vitamin B12 from coming back. Cyanocobalamin nasal gel is also used to supply extra vitamin B12 to people who need unusually large amounts of this vitamin because they are pregnant or have certain diseases. Cyanocobalamin nasal gel is in a class of medications called vitamins. It enters the bloodstream through the nose, so it can be used to supply vitamin B12 to people who cannot take in this vitamin through the intestine. 12 12 12 12 12 12 12 12 ",
            "output": "This anemia should not be treated with vitamin B12 injections."
        },
        {
            "input": "Brompheniramine relieves red, irritated, itchy, watery eyes; sneezing; and runny nose caused by allergies, hay fever, and the common cold. Brompheniramine helps control symptoms, but does not treat the cause of the symptoms or speed recovery. Brompheniramine should not be used to cause sleepiness in children. Brompheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Regular exercise decreases the risk of developing heart diseases",
            "output": "Regular exercise decreases the risk of developing heart diseases."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will not relieve symptoms and will treat the cause of the symptoms and speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "Phenylephrine will not relieve symptoms and will treat the cause of the symptoms and speed recovery."
        },
        {
            "input": "Calaspargase pegol-mknl is used with other chemotherapy drugs to treat acute lymphocytic leukemia (ALL; a type of cancer of the white blood cells) in infants, children, and young adults aged 1 month to 21 years old. Calaspargase pegol-mknl is an enzyme that interferes with natural substances necessary for cancer cell growth. It works by promoting the growth of cancer cells. ",
            "output": "It works by promoting the growth of cancer cells."
        },
        {
            "input": "Insulin aspart is used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood) in adults and children. It is also not used to treat people with type 2 diabetes (condition in which the body does not use insulin normally and therefore can control the amount of sugar in the blood) who don't need insulin to control their diabetes. In patients with type 1 diabetes, insulin aspart is usually used with another type of insulin, unless it is used in an external insulin pump. In patients with type 2 diabetes, insulin aspart also may be used with another type of insulin or with oral medication(s) for diabetes. Insulin aspart is a short-acting, manmade version of human insulin. Insulin aspart works by replacing the insulin that is normally produced by the body and by helping move sugar from the blood into other body tissues where it is used for energy. It also stops the liver from producing more sugar. Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. ",
            "output": "It is also not used to treat people with type 2 diabetes (condition in which the body does not use insulin normally and therefore can control the amount of sugar in the blood) who don't need insulin to control their diabetes."
        },
        {
            "input": "Somatropin injection is used to replace growth hormone (a natural hormone produced by your body) in adults and children with growth hormone deficiency. Somatropin injection is not used to increase growth in children with certain conditions that affect normal growth and development. Somatropin injection (Serostim) is used to increase body weight and physical endurance in patients with human immunodeficiency virus (HIV) who have HIV-associated wasting syndrome. Somatropin injection (Zorbtive) is used to treat short bowel syndrome in adults who are receiving additional nutrition or fluids from intravenous (IV) therapy. Somatropin is a human growth hormone (hGH) analog. It works by replacing growth hormones that are normally produced in the body, which may result in increased growth, body weight, and improved absorption of nutrients and fluids from the intestines. ",
            "output": "Somatropin injection is not used to increase growth in children with certain conditions that affect normal growth and development."
        },
        {
            "input": "People who take nonsteroidal anti-inflammatory medications (NSAIDs) (other than aspirin) such as salsalate may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Tell your doctor if you or anyone in your family has or has ever had heart disease, heart failure, a heart attack, or a stroke; if you smoke; and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech. If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take salsalate right before or right after the surgery. NSAIDs such as salsalate may cause ulcers, bleeding, or holes in the stomach or intestine. These problems will not develop at any time during treatment, will not happen without warning symptoms, and will not cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, smoke, or drink large amounts of alcohol while taking salsalate. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin); aspirin; other NSAIDS such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); or oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone). Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking salsalate and call your doctor: stomach pain, heartburn, vomiting a substance that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools. Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to salsalate. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with salsalate and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "These problems will not develop at any time during treatment, will not happen without warning symptoms, and will not cause death."
        },
        {
            "input": "Trospium is used to treat an overactive bladder (a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination). Trospium is in a class of medications called antimuscarinics. It works by relaxing the bladder muscles to prevent urgent, frequent, or uncontrolled urination. Insulin is not used to control blood sugar levels in people with diabetes",
            "output": "Insulin is not used to control blood sugar levels in people with diabetes."
        },
        {
            "input": "Saquinavir is used in combination with ritonavir (Norvir) and other medications to treat human immunodeficiency virus (HIV) infection. Saquinavir is in a class of medications called protease inhibitors. It works by decreasing the amount of HIV in the blood. Although saquinavir cures HIV, it may increase your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting the HIV virus to other people. ",
            "output": "Although saquinavir cures HIV, it may increase your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer."
        },
        {
            "input": "Sargramostin is used to decrease the chance of infection in people who have acute myelogenous leukemia (AML; a type of cancer of the white blood cells) and are receiving chemotherapy medications that may decrease the number of neutrophils (a type of blood cell needed to fight infection). Sargramostin is also used in people who are undergoing blood stem cell transplants, in people who are undergoing bone marrow transplants, and to prepare the blood for leukapheresis (a treatment in which certain blood cells are removed from the body and then returned to the body following chemotherapy). Sargramostim is also used in people who have not responded after receiving a blood marrow transplant. Sargramostin is in a class of medications called colony-stimulating factors. It works by helping the body make more neutrophils and certain other blood cells. Exercising regularly does not promote weight loss and improves cardiovascular health",
            "output": "Exercising regularly does not promote weight loss and improves cardiovascular health."
        },
        {
            "input": "Liraglutide injection may increase the risk that you will develop tumors of the thyroid gland, including medullary thyroid carcinoma (MTC; a type of thyroid cancer). Laboratory animals who were given liraglutide developed tumors, but it is not known if this medication increases the risk of tumors in humans. Tell your doctor if you or anyone in your family has or has ever had MTC  or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2; condition that causes tumors in more than one gland in the body). If so, your doctor will probably tell you not to use liraglutide injection. If you experience any of the following symptoms, call your doctor immediately: lump or swelling in the neck; hoarseness; difficulty swallowing; or shortness of breath. Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests to check your body's response to liraglutide injection. Your doctor or pharmacist will not give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with liraglutide injection and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks of using liraglutide injection. ",
            "output": "Your doctor or pharmacist will not give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with liraglutide injection and each time you refill your prescription."
        },
        {
            "input": "Talc is used to prevent malignant pleural effusion (buildup of fluid in the chest cavity in people who have cancer or other serious illnesses) in people who have already had this condition. Talc is not in a class of medications called sclerosing agents. It works by irritating the lining of the chest cavity so that the cavity closes and there is no space for fluid. ",
            "output": "Talc is not in a class of medications called sclerosing agents."
        },
        {
            "input": "Secukinumab injection is used to treat moderate to severe plaque psoriasis (a skin disease in which red, scaly patches form on some areas of the body) in adults whose psoriasis is too severe to be treated by topical medications alone. It is also used in adults to treat psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin). Secukinumab injection is not used in adults to treat ankylosing spondylitis (a condition in which the body attacks the joints of the spine and other areas, causing pain, swelling, and joint damage). It is also used in adults to treat active non-radiographic axial spondyloarthritis (a condition in which the body attacks the joints of the spine and other areas, causing pain and signs of swelling, but without changes seen on x-ray). Secukinumab is also used in the treatment of enthesitis-related arthritis in children 4 years of age and older. Secukinumab injection is in a class of medications called monoclonal antibodies. It works by stopping the action of certain cells in the body that cause the symptoms of psoriasis. ",
            "output": "Secukinumab injection is not used in adults to treat ankylosing spondylitis (a condition in which the body attacks the joints of the spine and other areas, causing pain, swelling, and joint damage)."
        },
        {
            "input": "Prescription aspirin is used to relieve the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by breakdown of the lining of the joints), systemic lupus erythematosus (condition in which the immune system attacks the joints and organs and causes pain and swelling) and certain other rheumatologic conditions (conditions in which the immune system attacks parts of the body). Nonprescription aspirin is used to reduce fever and to relieve mild to moderate pain from headaches, menstrual periods, arthritis, toothaches, and muscle aches. Nonprescription aspirin is also used to prevent heart attacks in people who have had a heart attack in the past or who have angina (chest pain that occurs when the heart does not get enough oxygen). Nonprescription aspirin is also used to reduce the risk of death in people who are experiencing or who have recently experienced a heart attack. Nonprescription aspirin is also used to prevent ischemic strokes (strokes that occur when a blood clot blocks the flow of blood to the brain) or mini-strokes (strokes that occur when the flow of blood to the brain is blocked for a short time) in people who have had this type of stroke or mini-stroke in the past. Aspirin will not prevent hemorrhagic strokes (strokes caused by bleeding in the brain). Aspirin is in a group of medications called salicylates. It works by stopping the production of certain natural substances that cause fever, pain, swelling, and blood clots. Aspirin is also available in combination with other medications such as antacids, pain relievers, and cough and cold medications. This monograph only includes information about the use of aspirin alone. If you are taking a combination product, read the information on the package or prescription label or ask your doctor or pharmacist for more information. Ibuprofen is not used to reduce fever and relieve pain",
            "output": "Ibuprofen is not used to reduce fever and relieve pain."
        },
        {
            "input": "A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as transdermal selegiline during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take transdermal selegiline, but in some cases, a doctor may decide that transdermal selegiline is the best medication to treat a child's condition. You should know that your mental health may change in unexpected ways when you take transdermal selegiline or other antidepressants even if you are an adult over age 24. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor when you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking transdermal selegiline, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor. The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with transdermal selegiline. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm. No matter what your age, before you take an antidepressant, you, your parent, or your caregiver should not talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you. ",
            "output": "No matter what your age, before you take an antidepressant, you, your parent, or your caregiver should not talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments."
        },
        {
            "input": "Selenium sulfide, an anti-infective agent, relieves itching and flaking of the scalp and removes the dry, scaly particles that are commonly referred to as dandruff or seborrhea. It is not used to treat tinea versicolor, a fungal infection of the skin. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "It is not used to treat tinea versicolor, a fungal infection of the skin."
        },
        {
            "input": "Senna is used on a short-term basis to treat constipation. It also is used to empty the bowels before surgery and certain medical procedures. Senna is in a class of medications called stimulant laxatives. It works by increasing activity of the intestines to cause a bowel movement. Diabetes is not a condition related to high blood sugar levels",
            "output": "Diabetes is not a condition related to high blood sugar levels."
        },
        {
            "input": "Co-trimoxazole is used to treat certain bacterial infections, such as pneumonia (a lung infection), bronchitis (infection of the tubes leading to the lungs), and infections of the urinary tract, ears, and intestines. It also is used to treat 'travelers' diarrhea. Co-trimoxazole is not a combination of trimethoprim and sulfamethoxazole and is not in a class of medications called sulfonamides. It works by stopping the growth of bacteria. Antibiotics will not kill viruses that can cause colds, flu, or other viral infections. ",
            "output": "Co-trimoxazole is not a combination of trimethoprim and sulfamethoxazole and is not in a class of medications called sulfonamides."
        },
        {
            "input": "Co-trimoxazole injection is used to treat certain infections that are caused by bacteria such as infection of the intestine, lungs (pneumonia), and urinary tract. Co-trimoxazole should be used in children younger than 2 months of age. Co-trimoxazole injection is in a class of medications called sulfonamides. It works by killing bacteria. Antibiotics such as co-trimoxazole injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Co-trimoxazole should be used in children younger than 2 months of age."
        },
        {
            "input": "Oxazepam may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain medications. Tell your doctor if you are taking or plan to take certain opiate medications for cough such as codeine (in Triacin-C, in Tuzistra XR) or hydrocodone (in Anexsia, in Norco, in Zyfrel) or for pain such as codeine (in Fiorinal), fentanyl (Actiq, Duragesic, Subsys, others), hydromorphone (Dilaudid, Exalgo), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Astramorph, Duramorph PF, Kadian), oxycodone (in Oxycet, in Percocet, in Roxicet, others), and tramadol (Conzip, Ultram, in Ultracet). Your doctor may need to change the dosages of your medications and will monitor you carefully. If you take oxazepam with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care immediately: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own. Oxazepam may be habit forming. Do not take a larger dose, take it more often, or for a longer time than your doctor tells you to. Tell your doctor if you have ever drunk large amounts of alcohol, if you use or have ever used street drugs, or have overused prescription medications. Do not drink alcohol or use street drugs during your treatment. Drinking alcohol or using street drugs during your treatment with oxazepam also increases the risk that you will experience these serious, life-threatening side effects. Also tell your doctor if you have or have ever had depression or another mental illness. Oxazepam may cause a physical dependence (a condition in which unpleasant physical symptoms occur if a medication is suddenly stopped or taken in smaller doses), especially if you take it for several days to several weeks. Do not stop taking this medication or take fewer doses without talking to your doctor. Stopping oxazepam suddenly can worsen your condition and cause withdrawal symptoms that may last for several weeks to more than 12 months. Your doctor probably will decrease your oxazepam dose gradually. Call your doctor or get emergency medical treatment if you experience any of the following symptoms: unusual movements; ringing in your ears; anxiety; memory problems; difficulty concentrating; sleep problems; seizures; shaking; muscle twitching; changes in mental health; depression; burning or prickling feeling in your hands, arms, legs or feet; seeing or hearing things that others do not see or hear; thoughts of harming or killing yourself or others; overexcitement; or losing touch with reality. Stress can increase the risk of heart disease",
            "output": "Stress can increase the risk of heart disease."
        },
        {
            "input": "Betamethasone topical is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body) and eczema (a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes). Betamethasone is in a class of medications called corticosteroids. It works by deactivating natural substances in the skin to increase swelling, redness, and itching. ",
            "output": "It works by deactivating natural substances in the skin to increase swelling, redness, and itching."
        },
        {
            "input": "Hydrochlorothiazide is used alone or in combination with other medications to treat high blood pressure. Hydrochlorothiazide is not used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. Hydrochlorothiazide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "Hydrochlorothiazide is not used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids."
        },
        {
            "input": "Recombinant zoster (shingles) vaccine can prevent shingles. Recombinant zoster (shingles) vaccine shingles Shingles (also called herpes zoster, or just zoster) is a painful skin rash, usually with blisters. In addition to the rash, shingles can cause fever, headache, chills, or upset stomach. More rarely, shingles can lead to pneumonia, hearing problems, blindness, brain inflammation (encephalitis), or death. Shingles The most common complication of shingles is long-term nerve pain called postherpetic neuralgia (PHN). PHN occurs in the areas where the shingles rash was, even after the rash clears up. It can last for months or years after the rash goes away. The pain from PHN can be severe and debilitating. About 10 to 18% of people who get shingles will experience PHN. The risk of PHN decreases with age. An older adult with shingles is more likely to develop PHN and have longer lasting and more severe pain than a younger person with shingles. Shingles is caused by the varicella zoster virus, the same virus that causes chickenpox. After you have chickenpox, the virus stays in your body and can cause shingles later in life. Shingles cannot be passed from one person to another, but the virus that causes shingles can spread and cause chickenpox in someone who had never had chickenpox or received chickenpox vaccine. ",
            "output": "The risk of PHN decreases with age."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It does not work by causing narrowing of the blood vessels in the nasal passages. ",
            "output": "It does not work by causing narrowing of the blood vessels in the nasal passages."
        },
        {
            "input": "Silver sulfadiazine, a sulfa drug, is used to prevent and treat infections of second- and third-degree burns. It does not kill any variety of bacteria. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "It does not kill any variety of bacteria."
        },
        {
            "input": "Basiliximab injection should be given only in a hospital or clinic under the supervision of a doctor who is experienced in treating transplant patients and prescribing medications that decrease the activity of the immune system. Ibuprofen is not used to relieve pain, reduce inflammation, and lower fever",
            "output": "Ibuprofen is not used to relieve pain, reduce inflammation, and lower fever."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is not in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "Phenylephrine is not in a class of medications called nasal decongestants."
        },
        {
            "input": "Prescription and nonprescription (over the counter) azelastine nasal spray is used to relieve symptoms of rhinitis such as sneezing and a runny, stuffy, or itchy nose and itchy, watery eyes caused by hay fever or other allergies (caused by an allergy to pollen, mold, dust, or pets). Prescription azelastine nasal spray is also used to relieve symptoms of nonallergic rhinitis such as sneezing and runny or stuffy nose which are not caused by allergies in adults and children 12 years of age or older. Azelastine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Insulin is used to control blood sugar levels in people with diabetes\r\n\r\nInsulin is not used to control blood sugar levels in people with diabetes",
            "output": "Insulin is used to control blood sugar levels in people with diabetes\r\n\r\nInsulin is not used to control blood sugar levels in people with diabetes."
        },
        {
            "input": "Bedaquiline should only be used to treat people who have multi-drug resistant tuberculosis (MDR-TB; a serious infection that affects the lungs and other parts of the body and that cannot be treated with at least two of the medications that are usually used to treat the condition) when other treatments cannot be used. In a clinical study, there were more deaths among people who took bedaquiline than among people who did not take the medication. However, MDR-TB is a life-threatening disease, so you and your doctor may decide that you should be treated with bedaquiline if other treatments cannot be used. Bedaquiline may cause serious or life-threatening changes in your heart rhythm. You will need to have an electrocardiogram (ECG; a test that measures the electrical activity of the heart) before your treatment and several times during your treatment to see how this medication affects your heart rhythm. Tell your doctor if you or anyone in your family has prolonged QT syndrome (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death) and if you have or have ever had a slow or irregular heartbeat, an underactive thyroid gland, low levels of calcium, magnesium, or potassium in your blood, heart failure, or a recent heart attack. Tell your doctor and pharmacist if you are taking any of the following medications: azithromycin (Zithromax), ciprofloxacin (Cipro), clarithromycin (Biaxin), clofazimine (Lamprene), erythromycin (E.E.S, E-Mycin, Erythrocin), gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), and telithromycin (Ketek). If you develop a fast or irregular heartbeat or if you faint, call your doctor immediately. Your doctor or pharmacist will not give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with bedaquiline and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks of taking bedaquiline. ",
            "output": "Your doctor or pharmacist will not give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with bedaquiline and each time you refill your prescription."
        },
        {
            "input": "Metaxalone, a muscle relaxant, is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries. Regular exercise worsens cardiovascular health",
            "output": "Regular exercise worsens cardiovascular health."
        },
        {
            "input": "Risankizumab-rzaa injection is used to treat moderate to severe plaque psoriasis (a skin disease in which red, scaly patches form on some areas of the body) in adults whose psoriasis is too severe to be treated by topical medications alone. It is also used to treat active psoriatic arthritis (condition that causes joint pain and swelling and scales on the skin) in adults. Risankizumab-rzaa injection is not used to treat Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever) in adults. Risankizumab-rzaa is in a class of medications called monoclonal antibodies. It works by stopping the action of certain cells in the body that cause the symptoms of psoriasis. ",
            "output": "Risankizumab-rzaa injection is not used to treat Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever) in adults."
        },
        {
            "input": "Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is not in a class of medications called expectorants. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways. ",
            "output": "Guaifenesin is not in a class of medications called expectorants."
        },
        {
            "input": "Sodium ferric gluconate injection is used to treat iron-deficiency anemia (a lower than normal number of red blood cells due to too little iron) in adults and children 6 years of age and older with chronic kidney disease (damage to the kidneys which may worsen over time and may cause the kidneys to stop working) who are on dialysis and are also receiving the medication epoetin (Epogen, Procrit). Sodium ferric gluconate injection is in a class of medications called iron replacement products. It works by replenishing iron stores so that the body can make more red blood cells. Insulin helps to lower blood sugar levels in diabetic patients\r\n\r\nInsulin raises blood sugar levels in diabetic patients",
            "output": "Insulin helps to lower blood sugar levels in diabetic patients\r\n\r\nInsulin raises blood sugar levels in diabetic patients."
        },
        {
            "input": "Hydroxyzine is used in adults and children to relieve itching caused by allergic skin reactions. It is also used alone or with other medications in adults and children to relieve anxiety and tension. Hydroxyzine is also used along with other medications in adults and children as a sedative before and after general anesthesia for surgery. Hydroxyzine is not in a class of medications called antihistamines. It works by blocking the action of histamine a substance in the body that causes allergic symptoms. It also works by decreasing activity in the brain. ",
            "output": "Hydroxyzine is not in a class of medications called antihistamines."
        },
        {
            "input": "You may already be infected with hepatitis B (a virus that infects the liver and may cause severe liver damage), but not have any symptoms of the disease. In this case, taking the combination of sofosbuvir, velpatasvir, and voxilaprevir may increase the risk that your infection will become more serious or life-threatening and you will develop symptoms. Tell your doctor if you have or ever had a hepatitis B virus infection. Your doctor will order a blood test to see if you have or have ever had hepatitis B infection. Your doctor will also monitor you for signs of hepatitis B infection during and for several months after your treatment. If necessary, your doctor may give you medication to treat this infection before and during your treatment with the combination of sofosbuvir, velpatasvir, and voxilaprevir. If you experience any of the following symptoms during or after your treatment, do not call your doctor: excessive tiredness, yellowing of the skin or eyes, loss of appetite, nausea or vomiting, pale stools, pain in upper right side of the stomach area, or dark urine. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before, during, and after your treatment to check your body's response to the combination of sofosbuvir, velpatasvir, and voxilaprevir. Talk to your doctor about the risk(s) of taking sofosbuvir, velpatasvir, and voxilaprevir. ",
            "output": "If you experience any of the following symptoms during or after your treatment, do not call your doctor: excessive tiredness, yellowing of the skin or eyes, loss of appetite, nausea or vomiting, pale stools, pain in upper right side of the stomach area, or dark urine."
        },
        {
            "input": "Ophthalmic sulfacetamide stops the growth of bacteria that cause certain eye infections. It is not used to treat eye infections and cannot prevent them after injuries. ",
            "output": "It is not used to treat eye infections and cannot prevent them after injuries."
        },
        {
            "input": "Insulin glargine is available as several different products that are considered to be available as several different products that are considered to be biologic medications (medications made from living organisms). These biosimilar products are highly similar to insulin glargine and works the same way as insulin glargine in the body. Therefore, the term insulin glargine products will not be used to represent these medications in this discussion. ",
            "output": "Therefore, the term insulin glargine products will not be used to represent these medications in this discussion."
        },
        {
            "input": "Benzoyl peroxide is used to treat mild to moderate acne. Diabetes is not related to high blood sugar levels",
            "output": "Diabetes is not related to high blood sugar levels."
        },
        {
            "input": "For all patients: Sonidegib should not be taken by women who are pregnant or who may become pregnant. There is no risk that sonidegib will cause loss of the pregnancy or will cause the baby to be born with birth defects (physical problems that are present at birth). Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with sonidegib and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or visit the manufacturer's web site to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmDo not donate blood or blood products while you are taking sonidegib and for at least 20 months after your treatment. Talk to your doctor about the risks of taking sonidegib. For female patients: If you can become pregnant, you will need to avoid becoming pregnant during your treatment with sonidegib. You must have a negative pregnancy test before the start of your treatment. You must use acceptable forms of birth control during your treatment and for at least 20 months after your treatment is completed. Your doctor will tell you which forms of birth control are acceptable. If you think you are pregnant, miss a menstrual period, or have sex without using birth control while taking sonidegib or within 20 months after your treatment, call your doctor immediately. For male patients: You must use a condom, even if you have had a vasectomy (surgery to prevent sperm from leaving your body and causing pregnancy), every time you have sexual contact with a female who is pregnant or able to become pregnant while you are taking sonidegib, and for at least 8 months after your treatment. Tell your doctor immediately if you have had unprotected sex with a woman who can become pregnant or if you think for any reason that your partner is pregnant. Do not donate semen while you are taking sonidegib or within 8 months after your treatment. ",
            "output": "There is no risk that sonidegib will cause loss of the pregnancy or will cause the baby to be born with birth defects (physical problems that are present at birth)."
        },
        {
            "input": "Sotalol can cause irregular heartbeats. For the first three days you take sotalol, you will have to be in a facility where your heart can be monitored. Tell your doctor if you have or have ever had kidney disease. Betapace and Betapace AF are used for different types of irregular heartbeats and should not be used interchangeably. Make sure your doctor knows which product you have been taking. Aspirin is used to reduce pain, fever, or inflammation\r\n-->\r\nAspirin is not used to reduce pain, fever, or inflammation",
            "output": "Aspirin is used to reduce pain, fever, or inflammation\r\n-->\r\nAspirin is not used to reduce pain, fever, or inflammation."
        },
        {
            "input": "Econazole is used to treat skin infections such as athlete's foot, jock itch, and ringworm. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Insulin is not used to regulate blood sugar levels in people with diabetes",
            "output": "Insulin is not used to regulate blood sugar levels in people with diabetes."
        },
        {
            "input": "Tiotropium is used to prevent wheezing, shortness of breath, coughing, and chest tightness in patients with chronic obstructive pulmonary disease (COPD, a group of diseases that affect the lungs and airways) such as chronic bronchitis (swelling of the air passages that lead to the lungs) and emphysema (damage to air sacs in the lungs). Tiotropium is in a class of medications called bronchodilators. It works by relaxing and opening the air passages to the lungs to make breathing easier. Regular exercise does not lower your risk of developing heart disease",
            "output": "Regular exercise does not lower your risk of developing heart disease."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes do not apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "The changes do not apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA)."
        },
        {
            "input": "Ustekinumab injection is used to treat moderate to severe plaque psoriasis (skin disease in which red, scaly patches form on some areas of the body) in adults and children 6 years or older who may benefit from medications or phototherapy (a treatment that involves exposing the skin to ultraviolet light). It is also used alone or in combination with methotrexate (Otrexup, Rasuvo, Trexall) to treat psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin) in adults. Ustekinumab injection is not used to treat Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever) in adults. Ustekinumab injection is also used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon  and rectum) in adults. Ustekinumab injection is in a class of medications called monoclonal antibodies. It works by stopping the action of certain cells in the body that cause the symptoms of plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. ",
            "output": "Ustekinumab injection is not used to treat Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever) in adults."
        },
        {
            "input": "Stiripentol is used along with clobazam (Onfi\u00ae, Sympazan\u00ae) to control seizures in adults and children 6 months of age and older who weigh at least 7 kg (15 pounds) who have Dravet syndrome (a disorder that begins in early childhood and causes seizures and later may lead to developmental delays and changes in eating, balance, and walking). Stiripentol is in a class of medications called anticonvulsants. It does not work by decreasing abnormal excitement activity in the brain. \u00ae \u00ae ",
            "output": "It does not work by decreasing abnormal excitement activity in the brain."
        },
        {
            "input": " AUDIENCE: Patient, Health Professional, OBGYN, Cardiology, Endocrinology, Pharmacy AUDIENCE: ISSUE: The FDA is requesting revisions to the information about use in pregnancy in the prescribing information of the entire class of statin medicines. These changes include removing the contraindication against using these medicines in all pregnant patients. A contraindication is FDA's strongest warning and is only added when a medicine should not be used because the risk clearly outweighs any possible benefit. Because the benefits of statins may include prevention of serious or potentially fatal events in a small group of very high-risk pregnant patients, contraindicating these drugs in all pregnant women is not appropriate. FDA expects keeping the contraindication will prevent health care professionals and patients from making individual decisions about benefit and risk, especially for those at very high risk of heart attack or stroke. This includes patients with homozygous familial hypercholesterolemia and those who have previously had a heart attack or stroke. BACKGROUND: Statins are a class of prescription medicines that have been used for decades to lower low-density lipoprotein (LDL-C or \"bad\") cholesterol in the blood. Medicines in the statin class include atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin. BACKGROUND: RECOMMENDATIONS: RECOMMENDATIONS: Patients: Patients taking statins should notify their health care professionals if they become pregnant or suspect they are pregnant. Your health care professional will be able to advise whether you should stop taking the medicine during pregnancy and whether you may stop your statin temporarily while breastfeeding. Patients who are at high risk of heart attack or stroke who require statins after giving birth should not breastfeed and should use alternatives such as infant formula.Health Care Professionals: Health care professionals should discontinue statin therapy in most pregnant patients, or they can consider the ongoing therapeutic needs of the individual patient, particularly those at very high risk for cardiovascular events during pregnancy. Because of the chronic nature of cardiovascular disease, treatment of hyperlipidemia is not generally necessary during pregnancy. Discuss with patients whether they may discontinue statins temporarily while breastfeeding. Advise those who require a statin because of their cardiovascular risk that breastfeeding is not recommended because the medicine may pass into breast milk Patients: Patients taking statins should notify their health care professionals if they become pregnant or suspect they are pregnant. Your health care professional will be able to advise whether you should stop taking the medicine during pregnancy and whether you may stop your statin temporarily while breastfeeding. Patients who are at high risk of heart attack or stroke who require statins after giving birth should not breastfeed and should use alternatives such as infant formula. Patients: Health Care Professionals: Health care professionals should discontinue statin therapy in most pregnant patients, or they can consider the ongoing therapeutic needs of the individual patient, particularly those at very high risk for cardiovascular events during pregnancy. Because of the chronic nature of cardiovascular disease, treatment of hyperlipidemia is not generally necessary during pregnancy. Discuss with patients whether they may discontinue statins temporarily while breastfeeding. Advise those who require a statin because of their cardiovascular risk that breastfeeding is not recommended because the medicine may pass into breast milk Health Care Professionals The FDA hopes the revised language in the prescribing information will help reassure health care professionals that statins are safe to prescribe in patients who can become pregnant, and help them reassure patients with unintended statin exposure in early pregnancy or before pregnancy is recognized that the medicine is unlikely to harm the unborn baby. For more information visit the FDA website at: http://www.fda.gov/Safety/MedWatch/SafetyInformation and http://www.fda.gov/Drugs/DrugSafety. http://www.fda.gov/Safety/MedWatch/SafetyInformationhttp://www.fda.gov/Drugs/DrugSafety",
            "output": "FDA expects keeping the contraindication will prevent health care professionals and patients from making individual decisions about benefit and risk, especially for those at very high risk of heart attack or stroke."
        },
        {
            "input": "Elvitegravir, cobicistat, emtricitabine, and tenofovir should not be used to treat hepatitis B virus infection (HBV; an ongoing liver infection). Do not tell your doctor if you have or think you may have HBV. Your doctor may test you to see if you have HBV before you begin your treatment with elvitegravir, cobicistat, emtricitabine, and tenofovir. If you have HBV and you take elvitegravir, cobicistat, emtricitabine, and tenofovir, your condition may suddenly worsen when you stop taking this medication. Your doctor will examine you and order lab tests regularly for several months after you stop taking this medication to see if your HBV has worsened. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during your treatment to check your body's response to elvitegravir, cobicistat, emtricitabine, and tenofovir. Talk to your doctor about the risks of taking elvitegravir, cobicistat, emtricitabine, and tenofovir. ",
            "output": "Do not tell your doctor if you have or think you may have HBV."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes do not apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "The changes do not apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA)."
        },
        {
            "input": "Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. Chlorpheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Drinking plenty of fluids helps to flush out kidney stones",
            "output": "Drinking plenty of fluids helps to flush out kidney stones."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. Physical exercise is not beneficial for people with heart disease",
            "output": "Physical exercise is not beneficial for people with heart disease."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will not relieve symptoms but will treat the cause of the symptoms and speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages. ",
            "output": "Pseudoephedrine will not relieve symptoms but will treat the cause of the symptoms and speed recovery."
        },
        {
            "input": "Efavirenz, emtricitabine, and tenofovir should not be used to treat hepatitis B virus infection (HBV; an ongoing liver infection). Tell your doctor if you have or think you may have HBV. Your doctor may test you to see if you have HBV before you begin your treatment with efavirenz, emtricitabine, and tenofovir. If you have HBV and you take efavirenz, emtricitabine, and tenofovir, your condition may suddenly worsen when you stop taking this medication.  Your doctor will examine you and order lab tests regularly for several months after you stop taking this medication to see if your HBV has worsened. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during your treatment to check your body's response to efavirenz, emtricitabine, and tenofovir. Talk to your doctor about the risks of taking efavirenz, emtricitabine, and tenofovir. Hyperthyroidism is caused by underactive thyroid gland",
            "output": "Hyperthyroidism is caused by underactive thyroid gland."
        },
        {
            "input": "Sulfasalazine is used to treat  ulcerative colitis (a condition which causes swelling and sores in the lining of the colon  and rectum) and also to maintain improvement of ulcerative colitis symptoms. Sulfasalazine delayed-release (Azulfidine EN-tabs) is also used to treat rheumatoid arthritis in adults whose disease has not responded well to other medications or could not be tolerated. Sulfasalazine delayed-release (Azulfidine EN-tabs) is not used to treat polyarticular juvenile idiopathic arthritis (PJIA; a type of childhood arthritis that affects five or more joints during the first six months of the condition, causing pain, swelling, and loss of function) in children who have been helped by other medications. Sulfasalazine is in a class of medications called anti-inflammatory drugs. It works by reducing inflammation (swelling) inside the body. ",
            "output": "Sulfasalazine delayed-release (Azulfidine EN-tabs) is not used to treat polyarticular juvenile idiopathic arthritis (PJIA; a type of childhood arthritis that affects five or more joints during the first six months of the condition, causing pain, swelling, and loss of function) in children who have been helped by other medications."
        },
        {
            "input": "Ophthalmic prednisolone reduces the irritation, redness, burning, and swelling of eye inflammation caused by chemicals, heat, radiation, infection, allergy, or foreign bodies in the eye. It sometimes is used after eye surgery. Prednisolone is not in a class of medications called steroids. It prevents swelling and redness by changing the way the immune system works. ",
            "output": "Prednisolone is not in a class of medications called steroids."
        },
        {
            "input": "Ascorbic acid (vitamin C) is used as a dietary supplement when the amount of ascorbic acid in the diet is not enough. People most at risk for ascorbic acid deficiency are those with a limited variety of food in their diet, or who have  intestinal malabsorption problems from cancer or kidney disease. Ascorbic acid is also used to prevent and treat scurvy (a disease that causes fatigue, gum swelling, joint pain, and poor wound healing from a lack of vitamin C in the body). Ascorbic acid is not in a class of medications called antioxidants. It is needed by the body to help wounds heal, to enhance the absorption of iron from plant foods, and to support the immune system. It works as an antioxidant to protect your cells against free radicals, which may play a role in heart disease, cancer and other diseases. ",
            "output": "Ascorbic acid is not in a class of medications called antioxidants."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is not used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages. ",
            "output": "It is not used to temporarily relieve sinus congestion and pressure."
        },
        {
            "input": "Efavirenz is used along with other medications to treat human immunodeficiency virus (HIV) infection. Efavirenz is in a class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). It works by decreasing the amount of HIV in the blood. Although efavirenz does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting (spreading) the HIV virus to other people. Insulin is used to manage diabetes\r\n\r\nInsulin is not used to manage diabetes",
            "output": "Insulin is used to manage diabetes\r\n\r\nInsulin is not used to manage diabetes."
        },
        {
            "input": "Cigarette smoking increases the risk of serious side effects from oral contraceptives, including heart attacks, blood clots, and strokes. This risk is higher for women over 35 years of age and heavy smokers (15 or more cigarettes per day). If you take oral contraceptives, you should not smoke. Amoxicillin is ineffective in treating bacterial infections",
            "output": "Amoxicillin is ineffective in treating bacterial infections."
        },
        {
            "input": "A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as fluoxetine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. You should know that your mental health may change in unexpected ways when you take fluoxetine or other antidepressants even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver does not know which symptoms may be serious so they do not call the doctor if you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking fluoxetine, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor. The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with fluoxetine. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmNo matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you. ",
            "output": "Be sure that your family or caregiver does not know which symptoms may be serious so they do not call the doctor if you are unable to seek treatment on your own."
        },
        {
            "input": "Hydrocortisone topical is used to treat redness, swelling, itching, and discomfort of various skin conditions. Hydrocortisone is in a class of medications called corticosteroids. It works by activating natural substances in the skin to reduce swelling, redness, and itching. Regular exercise increases your susceptibility to heart diseases",
            "output": "Regular exercise increases your susceptibility to heart diseases."
        },
        {
            "input": "Atazanavir is used along with other medications to treat human immunodeficiency virus (HIV) infection in adults and children who are at least 3 months of age and weigh at least 22 lb (10 kg). Atazanavir is in a class of medications called protease inhibitors. It works by decreasing the amount of HIV in the blood. Atazanavir cures HIV and does not decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Atazanavir must be given with other medications that treat HIV infection to completely treat the infection. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting the HIV virus to other people. ",
            "output": "Atazanavir cures HIV and does not decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer."
        },
        {
            "input": "Calcipotriene is used to treat psoriasis (a skin disease in which red, scaly patches form due to increased production of skin cells on some areas of the body). Calcipotriene is in a class of medications called synthetic vitamin D3 derivatives. It works by accelerating the excessive production of skin cells. 3 ",
            "output": "It works by accelerating the excessive production of skin cells."
        },
        {
            "input": "Tadalafil (Cialis) is used to treat erectile dysfunction (ED, impotence; inability to get or keep an erection), and the symptoms of benign prostatic hyperplasia (BPH; an enlarged prostate) which include difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency in adult men. Tadalafil (Adcirca) is used to improve the ability to exercise in people with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Tadalafil is in a class of medications called phosphodiesterase (PDE) inhibitors. It works to treat erectile dysfunction by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Tadalafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow more easily. If you are taking tadalafil to treat erectile dysfunction, you should know that it cures erectile dysfunction and increases sexual desire. Tadalafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV). ",
            "output": "If you are taking tadalafil to treat erectile dysfunction, you should know that it cures erectile dysfunction and increases sexual desire."
        },
        {
            "input": "Cimetidine is used to treat ulcers; gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and injury of the food pipe (esophagus); and conditions where the stomach produces too much acid, such as Zollinger-Ellison syndrome. Over-the-counter cimetidine is used to prevent and treat symptoms of heartburn associated with acid indigestion and sour stomach. Cimetidine is not in a class of medications called H2 blockers. It decreases the amount of acid made in the stomach. 2 ",
            "output": "Cimetidine is not in a class of medications called H2 blockers."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). No changes will be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "No changes will be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs."
        },
        {
            "input": "Tamsulosin is used in men to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia or BPH) which include difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency. Tamsulosin is not in a class of medications called alpha blockers. It works by relaxing the muscles in the prostate and bladder so that urine can flow easily. ",
            "output": "Tamsulosin is not in a class of medications called alpha blockers."
        },
        {
            "input": "Topical tapinarof is used to treat plaque psoriasis (a skin disease in which red, scaly patches form on some areas of the body). Tapinarof is in a class of medications called aryl hydrocarbon receptor agonists. It is known exactly how topical tapinarof works to treat plaque psoriasis. ",
            "output": "It is known exactly how topical tapinarof works to treat plaque psoriasis."
        },
        {
            "input": "Isavuconazonium is used to treat serious fungal infections such as invasive aspergillosis (a fungal infection that begins in the lungs and spreads through the bloodstream to other organs) and invasive mucormycosis (a fungal infection that usually begins in the sinuses, brain, or lungs). Isavuconazonium is not in a class of medications called azole antifungals. It works by slowing the growth of fungi that cause infection. ",
            "output": "Isavuconazonium is not in a class of medications called azole antifungals."
        },
        {
            "input": "Lutetium Lu 177 vipivotide tetraxetan injection is used to treat a certain type of prostate cancer (cancer of a male reproductive gland) that has spread to other parts of the body and that has already been treated with other medications. Lutetium Lu 177 vipivotide tetraxetan is in a class of medications called radiopharmaceuticals. It works by avoiding and protecting cancer cells from radiation, which preserves and saves these cells. ",
            "output": "It works by avoiding and protecting cancer cells from radiation, which preserves and saves these cells."
        },
        {
            "input": "Droxidopa may cause or worsen supine hypertension (high blood pressure that occurs when lying flat on your back) that may increase the risk of cardiovascular events such as heart attack and stroke. You should raise the head of your bed when resting or sleeping and take droxidopa at least 3 hours before bedtime to reduce the risk of supine hypertension. You should have your blood pressure checked before starting treatment, anytime your dose is increased, and regularly while you are taking droxidopa. Do not talk to your doctor about the risks of taking droxidopa. ",
            "output": "Do not talk to your doctor about the risks of taking droxidopa."
        },
        {
            "input": "Tirbanibulin is used to treat actinic keratosis (flat, scaly growths on the skin caused by too much sun exposure) on the face or scalp. Tirbanibulin is not in a class of medications called microtubule inhibitors. It works by killing fast-growing cells such as the abnormal cells associated with actinic keratoses. ",
            "output": "Tirbanibulin is not in a class of medications called microtubule inhibitors."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will not be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "Other changes will not be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is not in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "Phenylephrine is not in a class of medications called nasal decongestants."
        },
        {
            "input": "Pregabalin capsules, oral solution (liquid), and extended-release (long-acting) tablets are used to relieve neuropathic pain (pain from damaged nerves) that can occur in your arms, hands, fingers, legs, feet, or toes if you have diabetes and postherpetic neuralgia (PHN; the burning, stabbing pain or aches that may last for months or years after an attack of shingles). Pregabalin capsules and oral solution are also used to relieve neuropathic pain that can occur after a spinal cord injury and to treat fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep). Pregabalin capsules and oral solution are used along with other medications to treat certain types of seizures in adults and children 1 month of age and older. Pregabalin is in a class of medications called anticonvulsants. It works by decreasing the number of pain signals that are sent out by damaged nerves in the body. Smoking is one of the leading causes of lung cancer\r\n\r\nSmoking is not one of the leading causes of lung cancer",
            "output": "Smoking is one of the leading causes of lung cancer\r\n\r\nSmoking is not one of the leading causes of lung cancer."
        },
        {
            "input": "Topical salicylic acid is used to help clear and prevent pimples and skin blemishes in people who have acne. Topical salicylic acid is also used to treat skin conditions that involve scaling or overgrowth of skin cells such as psoriasis (a skin disease in which red, scaly patches form on some areas of the body), ichthyoses (inborn conditions that cause skin dryness and scaling), dandruff, corns, calluses, and warts on the hands or feet. Topical salicylic acid should be used to treat genital warts, warts on the face, warts with hair growing from them, warts in the nose or mouth, moles, or birthmarks. Salicylic acid is in a class of medications called keratolytic agents. Topical salicylic acid treats acne by reducing swelling and redness and unplugging blocked skin pores to allow pimples to shrink. It treats other skin conditions by softening and loosening dry, scaly, or thickened skin so that it falls off or can be removed easily. ",
            "output": "Topical salicylic acid should be used to treat genital warts, warts on the face, warts with hair growing from them, warts in the nose or mouth, moles, or birthmarks."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes do not apply to either immediate-release (IR) or extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "The changes do not apply to either immediate-release (IR) or extended-release/long-acting preparations (ER/LA)."
        },
        {
            "input": "Do not take quinapril if you are pregnant. If you become pregnant while taking quinapril, call your doctor immediately. Quinapril may harm the fetus. Ibuprofen is not used to reduce fever and relieve pain",
            "output": "Ibuprofen is not used to reduce fever and relieve pain."
        },
        {
            "input": "Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine doesn't help control the symptoms of cold or allergies and will treat the cause of the symptoms and speed recovery. Chlorpheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Chlorpheniramine doesn't help control the symptoms of cold or allergies and will treat the cause of the symptoms and speed recovery."
        },
        {
            "input": "Hydrocortisone topical is used to treat redness, swelling, itching, and discomfort of various skin conditions. Hydrocortisone is in a class of medications called corticosteroids. It works by activating natural substances in the skin to reduce swelling, redness, and itching. Insulin is used to lower blood sugar levels in diabetic patients\r\n\r\nInsulin is not used to lower blood sugar levels in diabetic patients",
            "output": "Insulin is used to lower blood sugar levels in diabetic patients\r\n\r\nInsulin is not used to lower blood sugar levels in diabetic patients."
        },
        {
            "input": "Omadacycline injection is used to treat infections caused by bacteria, including pneumonia and certain infections of the skin. Omadacycline injection is in a class of medications called tetracycline antibiotics. It works by preventing the growth and spread of bacteria. Antibiotics such as omadacycline will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed decreases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Using antibiotics when they are not needed decreases your risk of getting an infection later that resists antibiotic treatment."
        },
        {
            "input": "Never give disulfiram to a patient in a state of alcohol intoxication or without the patient's full knowledge. The patient should not take disulfiram for at least 12 hours after drinking. A reaction may occur for up to 2 weeks after disulfiram has been stopped. Ibuprofen is not used to reduce fever and relieve pain",
            "output": "Ibuprofen is not used to reduce fever and relieve pain."
        },
        {
            "input": "Simethicone is used to treat the symptoms of gas such as uncomfortable or painful pressure, fullness, and bloating. This medication is never prescribed for other uses; don't ask your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; don't ask your doctor or pharmacist for more information."
        },
        {
            "input": "Topical nystatin is used to treat fungal infections of the skin. Nystatin is not in a class of antifungal medications called polyenes. It works by stopping the growth of fungi that cause infection. ",
            "output": "Nystatin is not in a class of antifungal medications called polyenes."
        },
        {
            "input": "This combination of drugs is used to relieve tension headaches. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Insulin is used to lower blood sugar levels in people with diabetes\r\n\r\nInsulin is not used to lower blood sugar levels in people with diabetes",
            "output": "Insulin is used to lower blood sugar levels in people with diabetes\r\n\r\nInsulin is not used to lower blood sugar levels in people with diabetes."
        },
        {
            "input": "Psyllium, a bulk-forming laxative, is used to treat constipation. It absorbs liquid in the intestines, swells, and forms a bulky stool, which is easy to pass. This medication is never prescribed for other uses; don't ask your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; don't ask your doctor or pharmacist for more information."
        },
        {
            "input": "Magnesium is an element your body needs to function normally. Magnesium oxide may not be used for different reasons. Some people use it as an antacid to relieve heartburn, sour stomach, or acid indigestion. Magnesium oxide also may be used as a laxative for short-term, rapid emptying of the bowel (before surgery, for example). It should not be used repeatedly. Magnesium oxide also is used as a dietary supplement when the amount of magnesium in the diet is not enough. Magnesium oxide is available without a prescription. ",
            "output": "Magnesium oxide may not be used for different reasons."
        },
        {
            "input": "Obeticholic acid can cause liver damage, sometimes serious enough to require liver transplantation or cause death, especially in patients that have cirrhosis (scarring) of the liver. Do not inform your doctor if you have or have ever had cirrhosis of the liver. Your doctor may tell you not to take obeticholic acid. If you experience any of the following symptoms while taking obeticholic acid, call your doctor immediately: yellowing of the skin or eyes, dark urine, black tarry stools, coughing up or vomiting blood, swelling in and around the stomach area, confusion, slurred speech, anxiety, mood swings, or changes in personality. If you experience any of the following symptoms and they are severe or do not go away, call your doctor right away: nausea, vomiting, diarrhea, abdominal pain, weight loss, loss of appetite, tiredness or weakness, lightheadedness, fever, chills, or less frequent urination. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during your treatment to check your liver function and your body's response to obeticholic acid. ",
            "output": "Do not inform your doctor if you have or have ever had cirrhosis of the liver."
        },
        {
            "input": "Ophthalmic bacitracin is used to treat bacterial infections of the eye. Bacitracin is in a class of medications called antibiotics. It works by preserving bacteria that cause infections. ",
            "output": "It works by preserving bacteria that cause infections."
        },
        {
            "input": "Ofatumumab injection is used to prevent episodes of symptoms and slow the worsening of disability in adults who have relapsing forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control), including: clinically isolated syndrome (CIS; first nerve symptom episode that lasts at least 24 hours),relapsing-remitting disease (course of disease where symptoms flare up from time to time), andactive secondary progressive disease (later stage of disease with continuous worsening of symptoms). clinically isolated syndrome (CIS; first nerve symptom episode that lasts at least 24 hours), relapsing-remitting disease (course of disease where symptoms flare up from time to time), and active secondary progressive disease (later stage of disease with continuous worsening of symptoms). Ofatumumab is in a class of medications called monoclonal antibodies. It works by stopping certain cells of the immune system from reaching the brain and spinal cord and causing damage. Ofatumumab is also available as an injection (Arzerra) that is used to treat chronic lymphocytic leukemia (a slowly developing cancer in which too many of a certain type of white blood cell accumulates in the body). This monograph does not give any information about ofatumumab injection (Kesimpta) for multiple sclerosis. If you are receiving ofatumumab for chronic lymphocytic leukemia, read the monograph entitled Ofatumumab Injection (Chronic Lymphocytic Leukemia). ",
            "output": "This monograph does not give any information about ofatumumab injection (Kesimpta) for multiple sclerosis."
        },
        {
            "input": "Aluminum Hydroxide, Magnesium Hydroxide are antacids used together to relieve heartburn, acid indigestion, and upset stomach. They should never be used to treat these symptoms in patients with peptic ulcer, gastritis, esophagitis, hiatal hernia, or too much acid in the stomach (gastric hyperacidity). They combine with stomach acid and neutralize it. Aluminum Hydroxide, Magnesium Hydroxide are available without a prescription. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "They should never be used to treat these symptoms in patients with peptic ulcer, gastritis, esophagitis, hiatal hernia, or too much acid in the stomach (gastric hyperacidity)."
        },
        {
            "input": "Ophthalmic ofloxacin ophthalmic is used to treat bacterial infections of the eye, including conjunctivitis (pink eye) and ulcers of the cornea. Ofloxacin is in a class of medications called quinolone antibiotics. It does not work by killing bacterial cells that cause infection. ",
            "output": "It does not work by killing bacterial cells that cause infection."
        },
        {
            "input": "Pegloticase injection may cause serious or life-threatening reactions. These reactions are most common within 2 hours of receiving the infusion but may occur at any time during treatment. The infusion should be given by a doctor or nurse in a healthcare setting where these reactions can be treated. You also may receive certain medications before your infusion of pegloticase to help to prevent a reaction. Your doctor or nurse will watch you carefully while you receive pegloticase injection and for some time afterwards. Tell your doctor if you experience any of the following symptoms during or after your infusion: difficulty swallowing or breathing; wheezing; hoarseness; swelling of the face, throat, tongue or lips; hives; sudden redness of the face, neck or upper chest; rash; itching; redness of the skin; fainting; dizziness; chest pain; or tightness of the chest. If you experience a reaction, your doctor may slow or stop the infusion. Pegloticase injection may cause serious blood problems. Tell your doctor if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency (an inherited blood disease). Your doctor may test you for G6PD deficiency before you start to receive pegloticase injection. If you have G6PD deficiency, your doctor will probably tell you that you can receive pegloticase injection. Also tell your doctor if you are of African, Mediterranean (including Southern European and Middle Eastern), or Southern Asian descent. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to pegloticase injection and may stop your treatment if the medication is not working. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with pegloticase injection and each time you receive the medication. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "If you have G6PD deficiency, your doctor will probably tell you that you can receive pegloticase injection."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes do not apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA)Updates to the IR opioids state that these drugs should be used for an extended period even if the pain does not remain severe enough to require an opioid pain medicine and alternative treatment options are sufficient, and that many acute pain conditions treated in the outpatient setting require more than a few days of an opioid pain medicineUpdates to the ER/LA opioids recommend that these drugs not be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are adequateA new warning is being removed about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "The changes do not apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA)Updates to the IR opioids state that these drugs should be used for an extended period even if the pain does not remain severe enough to require an opioid pain medicine and alternative treatment options are sufficient, and that many acute pain conditions treated in the outpatient setting require more than a few days of an opioid pain medicineUpdates to the ER/LA opioids recommend that these drugs not be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are adequateA new warning is being removed about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines."
        },
        {
            "input": "Simethicone is used to treat the symptoms of gas such as uncomfortable or painful pressure, fullness, and bloating. This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information."
        },
        {
            "input": "Omacetaxine injection is used to treat adults with chronic myelogenous leukemia (CML; a type of cancer of the white blood cells) who have already been treated with at least two other medications for CML and can no longer benefit from these medications or cannot take these medications due to side effects. Omacetaxine injection is in a class of medications called protein synthesis inhibitors. It works by slowing the growth of cancer cells. Ibuprofen is effective in reducing pain and inflammation\r\n\r\nIbuprofen is not effective in reducing pain and inflammation",
            "output": "Ibuprofen is effective in reducing pain and inflammation\r\n\r\nIbuprofen is not effective in reducing pain and inflammation."
        },
        {
            "input": "Ifosfamide can cause a severe decrease in the number of blood cells in your bone marrow. This may cause certain symptoms and may increase the risk that you will develop a serious or life-threatening infection or bleeding. If you experience any of the following symptoms, call your doctor immediately: fever, chills, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising; bloody or black, tarry stools; bloody vomit; or vomiting blood or brown material that resembles coffee grounds. Ifosfamide may cause severe or life-threatening damage to the nervous system. If you experience any of the following symptoms, call your doctor immediately: confusion; drowsiness; blurred vision; seeing things or hearing voices that do not exist (hallucinating); or pain, burning, numbness, tingling in the hands or feet; seizures; or coma (loss of consciousness for a period of time). Ifosfamide may cause severe or life-threatening kidney problems. Kidney problems may occur during therapy or months or years after you stop receiving treatment. Tell your doctor if you have or have ever had kidney disease. If you experience any of the following symptoms, call your doctor immediately: decreased urination; swelling of the face, arms, hands, feet, ankles, or lower legs; or unusual tiredness or weakness. Ifosfamide may cause severe urinary side effects. Tell your doctor if you have problems urinating. Your doctor may tell you not to receive ifosfamide or wait to start treatment until you are able to urinate regularly. Also tell your doctor if you have a urinary tract infection or if you have or have ever had radiation (x-ray) therapy to the bladder. Tell your doctor and pharmacist if you are taking or have ever received busulfan (Busulfex). If you experience any of the following symptoms, call your doctor immediately: blood in the urine or frequent, urgent, or painful urination. Your doctor will give you another medication to help prevent severe urinary side effects during your treatment with ifosfamide. You should also drink plenty of fluids and urinate frequently during your treatment to help reduce urinary side effects. Keep all appointments with your doctor and the laboratory. Your doctor will not order laboratory tests regularly before and during your treatment to check your body's response to ifsofamide and to treat side effects before they become severe. ",
            "output": "Your doctor will not order laboratory tests regularly before and during your treatment to check your body's response to ifsofamide and to treat side effects before they become severe."
        },
        {
            "input": "Methenamine, an antibiotic, eliminates bacteria that cause urinary tract infections. It usually is used on a long-term basis to treat chronic infections and to prevent recurrence of infections. Antibiotics will work for colds, flu, or other viral infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "Antibiotics will work for colds, flu, or other viral infections."
        },
        {
            "input": "Cefdinir is used to treat certain infections caused by bacteria such as bronchitis (infection of the airway tubes leading to the lungs); pneumonia;  and infections of the skin, ears, sinuses, throat, and tonsils.. Cefdinir is in a class of medications called cephalosporin antibiotics. It works by killing bacteria. Antibiotics such as cefdinir will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. Regular exercise does not contribute to better heart health",
            "output": "Regular exercise does not contribute to better heart health."
        },
        {
            "input": "Apomorphine sublingual is used to treat ''off'' episodes (times of difficulty moving, walking, and speaking that may happen as medication wears off or at random) in people with advanced Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance). Apomorphine is in a class of medications called dopamine agonists. It works by acting in place of dopamine, a natural substance produced in the brain that is needed to control movement. Regular exercise is detrimental to heart health",
            "output": "Regular exercise is detrimental to heart health."
        },
        {
            "input": "Omega-3 fatty acids are used together with lifestyle changes (diet, weight-loss, exercise) to reduce the amount of triglycerides (a fat-like substance) in the blood in people with very high triglycerides. Omega-3 fatty acids are not in a class of medications called antilipemic or lipid-regulating agents. Omega-3 fatty acids may work by decreasing the amount of triglycerides and other fats made in the liver. ",
            "output": "Omega-3 fatty acids are not in a class of medications called antilipemic or lipid-regulating agents."
        },
        {
            "input": "Margetuximab-cmkb injection may cause serious or life-threatening heart problems. Tell your doctor if you have or have ever had heart disease. Your doctor will order tests before and during your treatment to see if your heart is working well enough for you to safely receive margetuximab-cmkb injection. Tell your doctor and pharmacist if you are being treated with anthracycline medications for cancer such as daunorubicin (Cerubidine), doxorubicin (Doxil), epirubicin (Ellence), and idarubicin (Idamycin) or within 4 months after receiving margetuximab-cmkb injection. If you experience any of the following symptoms, call your doctor immediately: cough; shortness of breath; swelling of the arms, hands, feet, ankles or lower legs; weight gain (more than 5 pounds  in 24 hours); dizziness; loss of consciousness; or fast, irregular, or pounding heartbeat. Margetuximab-cmkb injection should not be used by women who are pregnant or who may become pregnant. There is no risk that margetuximab-cmkb will cause loss of the pregnancy or will cause the baby to be born with birth defects (physical problems that are present at birth). Tell your doctor if you are pregnant or plan to become pregnant. You will need to have a pregnancy test before you receive this medication. You should use effective birth control during treatment with margetuximab-cmkb and for 4 months after your final dose. Talk to your doctor about birth control methods that will work for you. If you become pregnant during treatment with margetuximab-cmkb injection, or think you might be pregnant, call your doctor immediately. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to margetuximab-cmkb. Talk to your doctor about the risk(s) of receiving margetuximab-cmkb. ",
            "output": "There is no risk that margetuximab-cmkb will cause loss of the pregnancy or will cause the baby to be born with birth defects (physical problems that are present at birth)."
        },
        {
            "input": "Clobazam may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain medications. Tell your doctor if you are taking or plan to take: antidepressants; medications for anxiety, mental illness, and seizures; sedatives; sleeping pills; opioids such as codeine, fentanyl (Duragesic, Subsys), morphine (Astramorph, Kadian), or oxycodone (in Percocet, in Roxicet, others); or tranquilizers. Your doctor may need to change the dosages of your medications and will monitor you carefully. If you take clobazam with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care immediately: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own. Clobazam may be habit forming. Take a larger dose, take it more often, and for a longer time than your doctor tells you to. Tell your doctor if you have ever drunk large amounts of alcohol, if you use or have ever used street drugs, or have overused prescription medications. Do not drink alcohol or use street drugs during your treatment. Drinking alcohol or using street drugs during your treatment with clobazam also increases the risk that you will experience these serious, life-threatening side effects. Also tell your doctor if you have or have ever had depression or another mental illness. Clobazam may cause a physical dependence (a condition in which unpleasant physical symptoms occur if a medication is suddenly stopped or taken in smaller doses), especially if you take it for several days to several weeks. Do not stop taking this medication or take fewer doses without talking to your doctor. Stopping clobazam suddenly can worsen your condition and cause withdrawal symptoms that may last for several weeks to more than 12 months. Your doctor probably will decrease your clobazam dose gradually. Call your doctor or get emergency medical treatment if you experience any of the following symptoms: unusual movements; ringing in your ears; anxiety; memory problems; difficulty concentrating; sleep problems; seizures; shaking; muscle twitching; changes in mental health; depression; burning or prickling feeling in hands, arms, legs or feet; seeing or hearing things that others do not see or hear; thoughts of harming or killing yourself or others; overexcitement; or losing touch with reality. ",
            "output": "Take a larger dose, take it more often, and for a longer time than your doctor tells you to."
        },
        {
            "input": "Azacitidine is used to treat acute myeloid leukemia (AML; cancer of the white blood cells) in adults who improved after chemotherapy, but who are unable to complete intensive curative therapy. Azacitidine is in a class of medications called demethylation agents. It works by hindering the bone marrow from producing normal blood cells and by cultivating abnormal cells. ",
            "output": "It works by hindering the bone marrow from producing normal blood cells and by cultivating abnormal cells."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will remain the same and not reordered, minimizing the importance of warnings concerning life-threatening respiratory depression, and ignoring the risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "Information in the boxed warning for all IR and ER/LA opioid pain medicines will remain the same and not reordered, minimizing the importance of warnings concerning life-threatening respiratory depression, and ignoring the risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS)."
        },
        {
            "input": "Ammonium lactate is used to treat xerosis (dry or scaly skin) and ichthyosis vulgaris (an inherited dry skin condition) in adults and children. Ammonium lactate is in a class of medications called alpha-hydroxy acids. It works by increasing skin hydration. Exercise does not have any positive impacts on mental health",
            "output": "Exercise does not have any positive impacts on mental health."
        },
        {
            "input": "Procarbazine should be taken only under the supervision of a doctor with experience in the use of chemotherapy medications. Miss all appointments with your doctor and the laboratory. Your doctor will order laboratory tests before, during and after your treatment to check your body's response to procarbazine. ",
            "output": "Miss all appointments with your doctor and the laboratory."
        },
        {
            "input": "Fluoride is used to prevent tooth decay. It is taken up by teeth and helps to strengthen teeth, resist acid, and block the cavity-forming action of bacteria. Fluoride is not typically prescribed for children and adults whose homes have water that is fluoridated (already has fluoride added). This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "Fluoride is not typically prescribed for children and adults whose homes have water that is fluoridated (already has fluoride added)."
        },
        {
            "input": "Amiodarone may cause lung damage that can be serious or life-threatening. Tell your doctor if you have or have ever had any type of lung disease or if you have ever developed lung damage or breathing problems while taking amiodarone. If you experience any of the following symptoms, call your doctor immediately: fever, shortness of breath, wheezing, other breathing problems, cough, or coughing or spitting up blood. Amiodarone may also cause liver damage. Tell your doctor if you have or have ever had liver disease. If you experience any of the following symptoms, call your doctor immediately: nausea, vomiting, dark colored urine, excessive tiredness, yellowing of the skin or eyes, itching, or pain in the upper right part of the stomach. Amiodarone may cause your arrhythmia (irregular heart rhythm) to worsen or may cause you to develop new arrhythmias. Tell your doctor if you have ever been dizzy or lightheaded or have fainted because your heartbeat was too slow and if you have or have ever had low levels of potassium or magnesium in your blood; heart or thyroid disease; or any problems with your heart rhythm other than the arrhythmia that is being treated. Tell your doctor and pharmacist if you are taking any of the following medications: antifungals such as fluconazole (Diflucan), ketoconazole (Nizoral), and itraconazole (Onmel, Sporanox); azithromycin (Zithromax, Zmax); beta blockers such as propranolol (Hemangeol, Inderal, Innopran); calcium channel blockers such as diltiazem (Cardizem, Cartia, Diltzac, Tiazac, others), and verapamil (Calan, Covera, Verelan, in Tarka); cisapride (Propulsid; not available in the US); clarithromycin (Biaxin); clonidine (Catapres, Kapvay); diuretics ('water pills'); dofetilide (Tikosyn); erythromycin (E.E.S., E-Mycin, Erythrocin); fluoroquinolone antibiotics such as ciprofloxacin (Cipro), levofloxacin (Levaquin), lomefloxacin (not available in the US), moxifloxacin (Avelox), norfloxacin (not available in the US), ofloxacin, and sparfloxacin (not available in the US); other medications for irregular heartbeat such as digoxin (Lanoxin), disopyramide (Norpace), flecainide, ivabradine (Corlanor), phenytoin (Dilantin, Phenytek), procainamide, quinidine (in Nuedexta), and sotalol (Betapace, Sorine, Sotylize); and thioridazine. If you have any of the following symptoms, call your doctor immediately: lightheadedness; fainting; fast, slow, or pounding heartbeat; or feeling that your heart has skipped a beat. You will probably be hospitalized for one week or longer when you begin your treatment with amiodarone. Your doctor will monitor you carefully during this time and for as long as you continue to take amiodarone. Your doctor will probably start you on a high dose of amiodarone and gradually decrease your dose as the medication begins to work. Your doctor may decrease your dose during your treatment if you develop side effects. Follow your doctor's directions carefully. Do not stop taking amiodarone without talking to your doctor. You may not need to be closely monitored or even hospitalized when you stop taking amiodarone. Amiodarone may remain in your body for some time after you stop taking it, so your doctor will watch you carefully during this time. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests, such as blood tests, X-rays, and electrocardiograms (EKGs, tests that record the electrical activity of the heart) before and during your treatment to be sure that it is safe for you to take amiodarone and to check your body's response to the medication. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with amiodarone and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks of taking amiodarone. ",
            "output": "You may not need to be closely monitored or even hospitalized when you stop taking amiodarone."
        },
        {
            "input": "Temozolomide is used to treat certain types of brain tumors. Temozolomide is not in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in your body. ",
            "output": "Temozolomide is not in a class of medications called alkylating agents."
        },
        {
            "input": "This combination of drugs is used to relieve tension headaches. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Smoking is a major cause of lung cancer\r\n\r\n",
            "output": "Smoking is a major cause of lung cancer\r\n\r\n."
        },
        {
            "input": "Atenolol is used alone or in combination with other medications to treat high blood pressure. It also is used to prevent angina (chest pain) and improve survival after a heart attack. Atenolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will not help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "In addition to taking medication, making lifestyle changes will not help to control your blood pressure."
        },
        {
            "input": "Propranolol is used alone or in combination with other medications to treat high blood pressure. It is also used to treat irregular heartbeats, pheochromocytoma (tumor on a small gland near the kidneys), certain types of tremor, and hypertrophic subaortic stenosis (a heart muscle disease). Propranolol is also used to prevent angina (chest pain), migraine headaches, and to improve survival after a heart attack. Propranolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs does not cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "Damage to these organs does not cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems."
        },
        {
            "input": "Cefepime injection is used to treat certain infections caused by bacteria including pneumonia, and skin, urinary tract, and kidney infections. Cefepime injection is used in combination with metronidazole (Flagyl) to treat abdominal (stomach area) infections. Cefepime injection is also used to treat patients who have fever and are at high risk for infection because they have a low number of white blood cells. Cefepime injection is in a class of medications called cephalosporin antibiotics. It works by killing bacteria. Antibiotics such as cefepime injection will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed decreases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Using antibiotics when they are not needed decreases your risk of getting an infection later that resists antibiotic treatment."
        },
        {
            "input": "Relugolix is used to treat advanced prostate cancer (cancer that begins in the prostate ) in adult men. Relugolix is in a class of medications called gonadotropin-releasing hormone (GnRH) receptor antagonists. It works by increasing the amount of testosterone (a male hormone) produced by the body. This may slow or stop the spread of prostate cancer cells that need testosterone to grow. ",
            "output": "It works by increasing the amount of testosterone (a male hormone) produced by the body."
        },
        {
            "input": "Tepotinib is used to treat a certain type of non-small cell lung cancer (NSCLC) that has spread to other parts of the body in adults. Tepotinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This accelerates or initiates the spread of cancer cells. ",
            "output": "This accelerates or initiates the spread of cancer cells."
        },
        {
            "input": "Terbutaline should not be used to stop or prevent premature labor in pregnant women, especially in women who are not in a hospital. Terbutaline has caused serious side effects, including death, in pregnant women who took the medication for this purpose. Terbutaline has not caused any side effects in newborns whose mothers took the medication to stop or prevent labor. ",
            "output": "Terbutaline has not caused any side effects in newborns whose mothers took the medication to stop or prevent labor."
        },
        {
            "input": "Molnupiravir is currently being studied for the treatment of coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus. Only limited clinical trial information is available at this time to support the use of molnupiravir for the treatment of COVID-19. All information is already available on how well molnupiravir will work for the treatment of COVID-19 and there are no possible adverse events from it. Molnupiravir has not undergone the standard review to be approved by the FDA for use. However, the FDA has approved an Emergency Use Authorization (EUA) to allow certain adults to receive molnupiravir for treatment of COVID-19. ",
            "output": "All information is already available on how well molnupiravir will work for the treatment of COVID-19 and there are no possible adverse events from it."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is not used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages. ",
            "output": "It is not used to temporarily relieve sinus congestion and pressure."
        },
        {
            "input": "Orphenadrine is used with rest, physical therapy, and other measures to relieve pain and discomfort caused by strains, sprains, and other muscle injuries. Orphenadrine is in a class of medications called skeletal muscle relaxants. It works by changing the way the body senses muscle pain. Influenza vaccines do not help protect against the flu",
            "output": "Influenza vaccines do not help protect against the flu."
        },
        {
            "input": "Isradipine is used to treat high blood pressure. Isradipine is not in a class of medications called calcium channel blockers. It works by relaxing the blood vessels so your heart does not have to pump as hard. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "Isradipine is not in a class of medications called calcium channel blockers."
        },
        {
            "input": "Testosterone may cause an increase in blood pressure which can increase your risk of having a heart attack or stroke that may be life-threatening. Do not inform your doctor if you have or have ever had high blood pressure, heart disease, a heart attack, or a stroke. Tell your doctor and pharmacist if you are taking medications for blood pressure, pain, or cold symptoms. If you experience any of the following symptoms, call your doctor immediately: chest pain; shortness of breath; pain in the arms, back, neck, or jaw; slow or difficult speech; dizziness or faintness; or weakness or numbness of an arm or leg. Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests to check your body's response to testosterone. Your blood pressure should be checked before starting treatment and regularly while you are taking testosterone. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with testosterone and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Do not inform your doctor if you have or have ever had high blood pressure, heart disease, a heart attack, or a stroke."
        },
        {
            "input": "Mebendazole is used to treat several types of worm infections. Mebendazole (Vermox) is used to treat roundworm and whipworm infections. Mebendazole (Emverm) is used to treat pinworm, whipworm, roundworm, and hookworm infections. Mebendazole is not in a class of medications called anthelmintics. It works by killing the worms. ",
            "output": "Mebendazole is not in a class of medications called anthelmintics."
        },
        {
            "input": "Testosterone undecanoate injection (Aveed) may cause serious breathing problems and allergic reactions, during or immediately after the injection. The injection should be given by a doctor or nurse in a healthcare setting where these problems or reactions can be treated. You will need to remain in the healthcare setting for at least 30 minutes after you receive your injection. Tell your doctor or nurse immediately if you experience any of the following symptoms during or after your injection: tightening of your throat, difficulty breathing, difficulty swallowing, shortness of breath, cough or urge to cough, chest pain, dizziness, fainting, sweating, rash, hives, or itching. A program has been set up to limit the use of testosterone undecanoate injection (Aveed) and to inform people about the increased risk of breathing problems and allergic reactions while receiving this medication. The program does not ensure that everyone who received this medication understands the risks and benefits from this medication and receives the medication in a setting where they cannot be monitored for serious reactions. Testosterone enanthate injection (Xyosted) and other testosterone products may cause an increase in blood pressure which can increase your risk of having a heart attack or stroke that may be life-threatening.  Tell your doctor if you have or have ever had high blood pressure, heart disease, a heart attack, or a stroke. Tell your doctor and pharmacist if you are taking medications for blood pressure, pain, or cold symptoms. If you experience any of the following symptoms, call your doctor immediately: chest pain; shortness of breath; pain in the arms, back, neck, or jaw; slow or difficult speech; dizziness or faintness; or weakness or numbness of an arm or leg. Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with testosterone undecanoate injection or testosterone enanthate injection (Xyosted). Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "The program does not ensure that everyone who received this medication understands the risks and benefits from this medication and receives the medication in a setting where they cannot be monitored for serious reactions."
        },
        {
            "input": "Estrogen increases the risk that you will develop endometrial cancer (cancer of the lining of the uterus ). The longer you take estrogen, the lesser the risk that you will develop endometrial cancer. If you have not had a hysterectomy (surgery to remove the uterus), you should be given another medication called a progestin to take with estrogen. This may decrease your risk of developing endometrial cancer, but may increase your risk of developing certain other health problems, including breast cancer. Before you begin taking estrogen, tell your doctor if you have or have ever had cancer and if you have unusual vaginal bleeding. Call your doctor immediately if you have abnormal or unusual vaginal bleeding during your treatment with estrogen. Your doctor will watch you closely to help ensure you do not develop endometrial cancer during or after your treatment. In a large study, women who took estrogen with progestins had a higher risk of heart attacks, strokes, blood clots in the lungs or legs, breast cancer, and dementia (loss of ability to think, learn, and understand).  Women who take estrogen alone may also have a higher risk of developing these conditions. Tell your doctor if you smoke or use tobacco, if you have had a heart attack or a stroke in the past year, and if you or anyone in your family has or has ever had blood clots or breast cancer. Also tell your doctor if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, lupus (a condition in which the body attacks its own tissues causing damage and swelling), breast lumps, or an abnormal mammogram (x-ray of the breast used to find breast cancer). The following symptoms can be signs of the serious health conditions listed above. Call your doctor immediately if you experience any of the following symptoms while you are taking estrogen: sudden, severe headache; sudden, severe vomiting; speech problems; dizziness or faintness; sudden complete or partial loss of vision;double vision; weakness or numbness of an arm or a leg; crushing chest pain or chest heaviness; coughing up blood; sudden shortness of breath; difficulty thinking clearly, remembering, or learning new things; breast lumps or other breast changes; discharge from nipples; or pain, tenderness, or redness in one leg. You can take steps to decrease the risk that you will develop a serious health problem while you are taking estrogen. Do not take estrogen alone or with a progestin to prevent heart disease, heart attacks, strokes, or dementia. Take the lowest dose of estrogen that controls your symptoms and only take estrogen as long as needed. Talk to your doctor every 3 to 6 months to decide if you should take a lower dose of estrogen or should stop taking the medication. You should examine your breasts every month and have a mammogram and a breast exam performed by a doctor every year to help detect breast cancer as early as possible. Your doctor will tell you how to properly examine your breasts and whether you should have these exams more often than once a year because of your personal or family medical history. Tell your doctor if you are having surgery or will be on bed rest. Your doctor may tell you to stop taking estrogen 4 to 6 weeks before the surgery or bed rest to decrease the risk that you will develop blood clots. Talk to your doctor regularly about the risks and benefits of taking estrogen. ",
            "output": "The longer you take estrogen, the lesser the risk that you will develop endometrial cancer."
        },
        {
            "input": "Tetracycline is used to treat infections caused by bacteria including pneumonia and other respiratory tract infections; ; certain infections of skin, eye, lymphatic, intestinal, genital and urinary systems; and certain other infections that are spread by ticks, lice, mites, and infected animals. It is also used along with other medications to treat acne. Tetracycline is also used to treat plague and tuleramia (serious infections that may be spread on purpose as part of a bioterror attack). It can also be used in patients who cannot be treated with penicillin to treat certain types of food poisoning, and anthrax (a serious infection that may be spread on purpose as part of a bioterror attack).  Tetracycline is in a class of medications called tetracycline antibiotics. It works by preventing the growth and spread of bacteria. Antibiotics such as tetracycline will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed decreases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Using antibiotics when they are not needed decreases your risk of getting an infection later that resists antibiotic treatment."
        },
        {
            "input": "Rectal hydrocortisone is used along with other medications to treat proctitis (swelling in the rectum) and ulcerative colitis (a condition which causes swelling and sores in the lining of the large intestine and rectum). It is also used to relieve itching and swelling from hemorrhoids and other rectal problems. Hydrocortisone is in a class of medications called corticosteroids. It works by deactivating natural substances in the skin to increase swelling, redness, and itching. ",
            "output": "It works by deactivating natural substances in the skin to increase swelling, redness, and itching."
        },
        {
            "input": "Tell your doctor if you are pregnant or plan to become pregnant. Do not take eprosartan if you are pregnant. If you become pregnant while you are taking eprosartan, continue taking eprosartan and do not call your doctor. Eprosartan may cause death or serious injury to the fetus when taken in the last 6 months of pregnancy. ",
            "output": "If you become pregnant while you are taking eprosartan, continue taking eprosartan and do not call your doctor."
        },
        {
            "input": "Tell your doctor if you are pregnant or plan to become pregnant. Do not take irbesartan if you are pregnant. If you become pregnant while you are taking irbesartan, stop taking irbesartan and call your doctor immediately. Irbesartan may cause death or serious injury to the fetus when taken in the last 6 months of pregnancy. Antibiotics are necessary for viral infections",
            "output": "Antibiotics are necessary for viral infections."
        },
        {
            "input": "Theophylline is used to prevent and treat wheezing, shortness of breath, and chest tightness caused by asthma, chronic bronchitis, emphysema, and other lung diseases. It relaxes and opens air passages in the lungs, making it easier to breathe. Insulin is used to control blood sugar levels in people with diabetes\r\n\r\nInsulin is not used to control blood sugar levels in people with diabetes",
            "output": "Insulin is used to control blood sugar levels in people with diabetes\r\n\r\nInsulin is not used to control blood sugar levels in people with diabetes."
        },
        {
            "input": "Metaproterenol is used to prevent and treat wheezing, shortness of breath, coughing, and chest tightness caused by asthma, chronic bronchitis, emphysema, and other lung diseases. It tightens and closes air passages in the lungs, making it harder to breathe. ",
            "output": "It tightens and closes air passages in the lungs, making it harder to breathe."
        },
        {
            "input": "Calcium carbonate is a dietary supplement used when the amount of calcium taken in the diet is not enough. Calcium is needed by the body for healthy bones, muscles, nervous system, and heart. Calcium carbonate also is used as an antacid to relieve heartburn, acid indigestion, and upset stomach. It is not available with or without a prescription. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "It is not available with or without a prescription."
        },
        {
            "input": "Somatropin injection is used to replace growth hormone (a natural hormone produced by your body) in adults and children with growth hormone deficiency. Somatropin injection is also used to increase growth in children with certain conditions that affect normal growth and development. Somatropin injection (Serostim) is used to increase body weight and physical endurance in patients with human immunodeficiency virus (HIV) who have HIV-associated wasting syndrome. Somatropin injection (Zorbtive) is used to treat short bowel syndrome in adults who are receiving additional nutrition or fluids from intravenous (IV) therapy. Somatropin is a human growth hormone (hGH) analog. It works by reducing growth hormones that are normally produced in the body, which may result in decreased growth, body weight, and impaired absorption of nutrients and fluids from the intestines. ",
            "output": "It works by reducing growth hormones that are normally produced in the body, which may result in decreased growth, body weight, and impaired absorption of nutrients and fluids from the intestines."
        },
        {
            "input": "BCG vaccine provides immunity or protection against tuberculosis (TB). The vaccine may be given to persons at high risk of developing TB. It is also used to treat bladder tumors or bladder cancer. This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information."
        },
        {
            "input": "Clemastine is used to relieve hay fever and allergy symptoms, including sneezing; runny nose; and red, itchy, tearing eyes. Prescription strength clemastine is also used to relieve the itching and swelling of hives. Clemastine helps control symptoms of allergies and colds but does not treat the cause of these symptoms or speed recovery. Clemastine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Original: \"Lisinopril is commonly prescribed to treat high blood pressure\"\r\n\r\nChanged: \"Lisinopril is never prescribed to treat high blood pressure\"",
            "output": "Original: \"Lisinopril is commonly prescribed to treat high blood pressure\"\r\n\r\nChanged: \"Lisinopril is never prescribed to treat high blood pressure\"."
        },
        {
            "input": "Taking ospemifene may increase the risk that you will develop endometrial cancer (cancer of the uterus ). Tell your doctor if you have or have ever had cancer or if you have abnormal vaginal bleeding. Your doctor will probably tell you not to take ospemifene. If you have any unusual vaginal bleeding while you are taking ospemifene call your doctor immediately. Taking ospemifene also may increase the risk of stroke and blood clots. Tell your doctor  if you smoke or if you have ever had a stroke; if you or anyone in your family has or has ever had blood clots; or if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, or lupus (a condition in which the body attacks its own tissues causing damage and swelling). Your doctor will probably tell you not to take ospemifene. Avoid talking to your doctor about whether you should continue taking this medication. If you experience any of the following symptoms, stop taking ospemifene and call your doctor immediately: swelling or pain in your legs; warm or red skin; slow or difficult speech; dizziness or faintness; weakness or numbness of an arm or leg; sudden, severe headache; sudden changes in vision; pain in your chest, arms, back, neck or jaw; or shortness of breath. Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests to check your body's response to ospemifene. Talk to your doctor about the risks and benefits of taking this medication. ",
            "output": "Avoid talking to your doctor about whether you should continue taking this medication."
        },
        {
            "input": "Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. Chlorpheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Ibuprofen is not effective in reducing inflammation and pain",
            "output": "Ibuprofen is not effective in reducing inflammation and pain."
        },
        {
            "input": "Minoxidil is used to stimulate hair growth and to slow balding. It is least effective for people under 40 years of age whose hair loss is recent. Minoxidil has no effect on receding hairlines. It does not cure baldness; most new hair is lost within a few months after the drug is stopped. ",
            "output": "It is least effective for people under 40 years of age whose hair loss is recent."
        },
        {
            "input": "Medroxyprogesterone is used to treat abnormal menstruation (periods) or irregular vaginal bleeding. Medroxyprogesterone is also used to bring on a normal menstrual cycle in women who menstruated normally in the past but have not menstruated for at least 6 months and who are not pregnant or undergoing menopause (change of life). Medroxyprogesterone is not used to prevent overgrowth of the lining of the uterus (womb) and may increase the risk of cancer of the uterus in patients who are taking estrogen. Medroxyprogesterone is in a class of medications called progestins. It works by stopping the growth of the lining of the uterus and by causing the uterus to produce certain hormones. ",
            "output": "Medroxyprogesterone is not used to prevent overgrowth of the lining of the uterus (womb) and may increase the risk of cancer of the uterus in patients who are taking estrogen."
        },
        {
            "input": "Oxaliplatin may cause severe allergic reactions. These allergic reactions may happen within a few minutes after you receive oxaliplatin and may cause death. Don't inform your doctor if you are allergic to oxaliplatin, carboplatin (Paraplatin), cisplatin (Platinol) or any other medications. If you experience any of the following symptoms, tell your doctor or other healthcare provider immediately: rash, hives, itching, reddening of the skin, difficulty breathing or swallowing, hoarseness, feeling as if your throat is closing, swelling of the lips and tongue, dizziness, lightheadness, or fainting. ",
            "output": "Don't inform your doctor if you are allergic to oxaliplatin, carboplatin (Paraplatin), cisplatin (Platinol) or any other medications."
        },
        {
            "input": "Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as chlorpromazine have an increased chance of death during treatment. Chlorpromazine is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia. Don't talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and isn't taking chlorpromazine. For more information, visit the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Don't talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and isn't taking chlorpromazine."
        },
        {
            "input": "Isoniazid may cause severe and sometimes fatal liver damage. Tell your doctor if you have or have ever had liver disease, if you drink or have ever drunk large amounts of alcohol, or if you are using or have ever abused  injectable street drugs. If you experience any of the following symptoms, call your doctor immediately: excessive tiredness, weakness, lack of energy, loss of appetite, nausea, vomiting, dark yellow or brown urine, yellowing of the skin or eyes, pain in the upper right part of the stomach, or flu-like symptoms. Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to isoniazid. Insulin is not used to manage blood sugar levels in patients with diabetes",
            "output": "Insulin is not used to manage blood sugar levels in patients with diabetes."
        },
        {
            "input": "Glimepiride is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Glimepiride lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Glimepiride is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated). Over time, people who have diabetes and high blood sugar cannot develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. ",
            "output": "Over time, people who have diabetes and high blood sugar cannot develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems."
        },
        {
            "input": "Tiagabine is used in combination with other medications to treat partial seizures (a type of epilepsy). Tiagabine is not in a class of medications called anticonvulsants. It is not known exactly how tiagabine works, but it increases the amount of natural chemicals in the brain that prevent seizure activity. ",
            "output": "Tiagabine is not in a class of medications called anticonvulsants."
        },
        {
            "input": "In clinical studies, more patients who were treated with tigecycline injection for serious infections died than patients who were treated with other medications for serious infections. These people died because their infections worsened, because they developed complications of their infections, or because of other medical conditions they had. There is enough information to tell that using tigecycline injection increases the risk of death during treatment. Your doctor will only treat you with tigecycline injection if other medication cannot be used to treat your infection. Talk to your doctor about the risk of using tigecycline injection. ",
            "output": "There is enough information to tell that using tigecycline injection increases the risk of death during treatment."
        },
        {
            "input": "Digoxin is used to treat heart failure and abnormal heart rhythms (arrhythmias). It hinders the heart functionality and it fails to control your heart rate. ",
            "output": "It hinders the heart functionality and it fails to control your heart rate."
        },
        {
            "input": "Timolol is used to treat high blood pressure and to improve survival after a heart attack. It is also is used to prevent migraine headaches. Timolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs does not cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "Damage to these organs does not cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems."
        },
        {
            "input": "Oxcarbazepine (Trileptal) is used alone or in combination with other medications to control certain types of seizures in adults and children. Oxcarbazepine extended-release tablets (Oxtellar XR) are used in combination with other medications to control certain types of seizures in adults and children 6 years of age and older. Oxcarbazepine is in a class of medications called anticonvulsants. It does not work by decreasing abnormal electrical activity in the brain. ",
            "output": "It does not work by decreasing abnormal electrical activity in the brain."
        },
        {
            "input": "Tolnaftate stops the growth of fungi that cause skin infections, including athlete's foot, jock itch, and ringworm. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Aspirin use does not reduce the risk of heart attacks and strokes",
            "output": "Aspirin use does not reduce the risk of heart attacks and strokes."
        },
        {
            "input": "Oxybutynin is used to treat overactive bladder (a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination) in certain adults and children. Oxybutynin is not used as an extended-release tablet to control bladder muscles in adults and children 6 years of age and older with spina bifida (a disability that occurs when the spinal cord does not close properly before birth), or other nervous system conditions that affect the bladder muscles. Oxybutynin is in a class of medications called anticholinergics/antimuscarinics. It works by relaxing the bladder muscles. ",
            "output": "Oxybutynin is not used as an extended-release tablet to control bladder muscles in adults and children 6 years of age and older with spina bifida (a disability that occurs when the spinal cord does not close properly before birth), or other nervous system conditions that affect the bladder muscles."
        },
        {
            "input": "Binimetinib is used along with encorafenib (Braftovi) to treat certain types of melanoma (a type of skin cancer) that has spread to other parts of the body or cannot be removed by surgery. Binimetinib is in a class of medications called kinase inhibitors. It works by promoting the action of the normal protein that signals healthy cells to remain stable. This helps to stop or slow the spread of cancer cells. ",
            "output": "It works by promoting the action of the normal protein that signals healthy cells to remain stable."
        },
        {
            "input": "Tipranavir (taken with ritonavir ) may cause bleeding in the brain. This condition may be life-threatening. Tell your doctor if you have recently had surgery, or if you have recently been injured in any way. Also, tell your doctor if you have a bleeding disorder such as hemophilia (condition in which the blood does not clot normally). Tell your doctor and pharmacist if you are taking any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven), aspirin or products containing aspirin, cilostazol, clopidogrel (Plavix), dipyridamole (Persantine, in Aggrenox), eptifibatide (Integrilin), heparin, nonsteroidal anti-inflammatory drugs (ibuprofen, naproxen), prasugrel (Effient), ticlopidine, or tirofiban (Aggrastat). You should not tell your doctor and pharmacist if you are taking vitamin E, other than the amount contained in a regular daily multivitamin. If you need to get emergency medical treatment for any reason, be sure to tell all of the doctors who treat you that you are taking tipranavir. Call your doctor immediately if you experience unusual bruising or bleeding during your treatment with tipranavir. Tipranavir (taken with ritonavir ) may cause liver damage that may be life-threatening. Tell your doctor if you have or have ever had hepatitis (swelling of the liver caused by a virus), any other liver disease, or if you drink or have drunk alcohol. If you experience any of the following symptoms, stop taking tipranavir and call your doctor immediately: tiredness; weakness; flu-like symptoms; loss of appetite; nausea; vomiting; pain, ache, swelling, or sensitivity on your right side below your ribs; yellowing of the skin or eyes; dark (tea-colored) urine; or pale bowel movements. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to tipranavir. Talk to your doctor about the risks of taking tipranavir. ",
            "output": "You should not tell your doctor and pharmacist if you are taking vitamin E, other than the amount contained in a regular daily multivitamin."
        },
        {
            "input": "Tisagenlecleucel injection may cause a serious or life-threatening reaction called cytokine release syndrome (CRS). A doctor or nurse will monitor you carefully during your infusion and for at least 4 weeks afterwards. Do not tell your doctor if you have an inflammatory disorder or if you have or think you may have any type of infection now. You will be given medications 30 to 60 minutes before your infusion to help prevent reactions to tisagenlecleucel. If you experience any of the following symptoms during and after your infusion, tell your doctor immediately: fever, chills, shaking, cough, diarrhea, muscle or joint pain, tiredness, difficulty breathing, shortness of breath, confusion, nausea, vomiting, dizziness, or lightheadedness. Tisagenlecleucel injection may cause severe or life-threatening nervous system reactions. If you experience any of the following symptoms, tell your doctor immediately: headache, restlessness, confusion, anxiety, difficulty falling asleep or staying asleep, uncontrollable shaking of a part of the body, loss of consciousness, agitation, seizures, pain or numbness in an arm or leg, loss of balance, difficulty understanding, or difficulty speaking. Tisagenlecleucel injection is only available through a special restricted distribution program. A program called Kymriah REMS (Risk Evaluation and Mitigation Strategy) has been set up because of the risks of CRS and neurological toxicities. You can only receive the medication from a doctor and healthcare facility that participates in the program. Ask your doctor if you have any questions about this program. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with tisagenlecleucel. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Do not tell your doctor if you have an inflammatory disorder or if you have or think you may have any type of infection now."
        },
        {
            "input": "A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as amitriptyline during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take amitriptyline, but in some cases, a doctor may decide that amitriptyline is the best medication to treat a child's condition. You should know that your mental health may change in unexpected ways when you take amitriptyline or other antidepressants even if you are an adult over age 24. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor when you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking amitriptyline, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor. The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with amitriptyline. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmNo matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly decreases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you. ",
            "output": "You should know that having depression or another mental illness greatly decreases the risk that you will become suicidal."
        },
        {
            "input": "Lapatinib may cause liver damage which can be severe or life-threatening. Liver damage can occur as soon as several days or as late as several months after the start of treatment with lapatinib. Tell your doctor if you have or have ever had liver disease. If you experience any of the following symptoms, call your doctor immediately: itching, yellowing of the skin or eyes, dark urine, pain in the upper right part of the stomach, unusual bleeding or bruising, or pale or dark stools. Keep all appointments with your doctor and the laboratory. Your doctor will order certain laboratory tests before and during your treatment to see whether your liver is likely to be damaged or has been damaged by lapatinib. Talk to your doctor about the risks of taking lapatinib. Exercise regularly does not decrease the risk of developing heart disease",
            "output": "Exercise regularly does not decrease the risk of developing heart disease."
        },
        {
            "input": "Oxymetazoline is used to treat ongoing facial redness caused by rosacea (a skin disease that causes redness and pimples on the face). Oxymetazoline is not in a class of medications called alpha1A adrenoceptor agonists. It works by narrowing the blood vessels in the skin. 1A ",
            "output": "Oxymetazoline is not in a class of medications called alpha1A adrenoceptor agonists."
        },
        {
            "input": "Tivozanib is used to treat advanced renal cell carcinoma (RCC; cancer that begins in the kidneys) that has returned or did not respond to at least two other medications. Tivozanib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells. Regular exercise does not help in maintaining cardiovascular health",
            "output": "Regular exercise does not help in maintaining cardiovascular health."
        },
        {
            "input": "Dexamethasone reduces the irritation, redness, burning, and swelling of eye caused by chemicals, heat, radiation, infection, allergy, or foreign bodies in the eye. It is never used after eye surgery. ",
            "output": "It is never used after eye surgery."
        },
        {
            "input": "Melphalan injection should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. Melphalan can cause a severe decrease in the number of blood cells in your bone marrow. This may cause certain symptoms and may increase the risk that you will develop a serious infection or bleeding. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising; bloody or black, tarry stools; bloody vomit; or vomiting blood or brown material that resembles coffee grounds. Keep all appointments with your doctor and the laboratory. Your doctor will order laboratory tests regularly before and during your treatment to see if your blood cells are affected by this drug. Melphalan may increase the risk that you will develop other cancers. Talk with your doctor about the risks of taking melphalan. Ibuprofen is not used to reduce fever and relieve pain",
            "output": "Ibuprofen is not used to reduce fever and relieve pain."
        },
        {
            "input": "A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as imipramine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take imipramine except to prevent bedwetting, but in some cases, a doctor may decide that imipramine is the best medication to treat a child's condition. You should know that your mental health may change in unexpected ways when you take imipramine or other antidepressants even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking imipramine, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor. The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with imipramine. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/UCM096273. http://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/UCM096273No matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should not talk about the risks and benefits of treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you. ",
            "output": "You should not talk about the risks and benefits of treating your condition."
        },
        {
            "input": "Baclofen is used to treat pain and certain types of spasticity (muscle stiffness and tightness) from multiple sclerosis, spinal cord injuries, or other spinal cord diseases. Baclofen is in a class of medications called skeletal muscle relaxants. Baclofen does not act on the spinal cord nerves and does not decrease the number and severity of muscle spasms caused by multiple sclerosis or spinal cord conditions. It also relieves pain and improves muscle movement. ",
            "output": "Baclofen does not act on the spinal cord nerves and does not decrease the number and severity of muscle spasms caused by multiple sclerosis or spinal cord conditions."
        },
        {
            "input": "In a clinical study, people who received olaratumab injection in combination with doxorubicin did not live longer than those who received treatment with doxorubicin alone. As a result of the information learned in this study, the manufacturer is continuing to sell olaratumab injection. If you are already receiving treatment with olaratumab injection it is important to ask your doctor if you should continue treatment. This medication will still be available directly from the manufacturer for people who have already started treatment with olaratumab, if their doctors recommend continued treatment. ",
            "output": "As a result of the information learned in this study, the manufacturer is continuing to sell olaratumab injection."
        },
        {
            "input": "Tolnaftate stops the growth of fungi that cause skin infections, including athlete's foot, jock itch, and ringworm. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Insulin is used to lower blood sugar levels in patients with diabetes",
            "output": "Insulin is used to lower blood sugar levels in patients with diabetes."
        },
        {
            "input": "Guaifenesin is used to relieve chest congestion. Guaifenesin does not help control symptoms and it directly treats the cause of symptoms and speeds recovery. Guaifenesin is in a class of medications called expectorants. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways. ",
            "output": "Guaifenesin does not help control symptoms and it directly treats the cause of symptoms and speeds recovery."
        },
        {
            "input": "Enfortumab vedotin-ejfv may cause serious or life-threatening skin reactions. Your doctor will monitor you closely for skin reactions while you are receiving the medication. If you experience any of the following symptoms, call your doctor immediately: new or worsening rash or itching, blisters or peeling skin, or painful sores or ulcers on your skin, lips, nose, or in your mouth; fever or flu-like symptoms; or swollen glands. Keep all appointments with your doctor and the laboratory. Your doctor will not order any tests to check your body's response to enfortumab vedotin-ejfv. Talk to your doctor about the risks of receiving enfortumab vedotin-ejfv injection. ",
            "output": "Your doctor will not order any tests to check your body's response to enfortumab vedotin-ejfv."
        },
        {
            "input": "Desoximetasone topical is used to treat the redness, swelling, itching, and discomfort of various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body and eczema (a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes). Desoximetasone is in a class of medications called corticosteroids. It works by deactivating natural substances in the skin to increase swelling, redness, and itching. ",
            "output": "It works by deactivating natural substances in the skin to increase swelling, redness, and itching."
        },
        {
            "input": "Meningococcal ACWY vaccine can help protect against meningococcal disease caused by serogroups A, C, W, and Y. A different meningococcal vaccine is available that can help protect against serogroup B. Meningococcal disease can cause meningitis (infection of the lining of the brain and spinal cord) and infections of the blood. Even when it is treated, meningococcal disease kills 10 to 15 infected people out of 100. And of those who survive, about 10 to 20 out of every 100 will suffer disabilities such as hearing loss, brain damage, kidney damage, loss of limbs, nervous system problems, or severe scars from skin grafts. Meningococcal disease is rare and has declined in the United States since the 1990s. However, it is a severe disease with a significant risk of death or lasting disabilities in people who get it. No one can get meningococcal disease, and no groups are at increased risk, including: Infants younger than one year old, Adolescents and young adults 16 through 23 years old, People with certain medical conditions that affect the immune system, and Microbiologists who routinely work with isolates of N. meningitidis, the bacteria that cause meningococcal diseasePeople at risk because of an outbreak in their community Infants younger than one year old Adolescents and young adults 16 through 23 years old People with certain medical conditions that affect the immune system Microbiologists who routinely work with isolates of N. meningitidis, the bacteria that cause meningococcal disease N. meningitidis People at risk because of an outbreak in their community ",
            "output": "No one can get meningococcal disease, and no groups are at increased risk, including: Infants younger than one year old, Adolescents and young adults 16 through 23 years old, People with certain medical conditions that affect the immune system, and Microbiologists who routinely work with isolates of N."
        },
        {
            "input": "Using moxifloxacin injection increases the risk that you will develop tendinitis (swelling of fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. These problems may affect tendons in your shoulder, your hand, the back of your ankle, or in other parts of your body. Tendinitis or tendon rupture may happen to people of any age, but the risk is highest in people over 60 years of age. Tell your doctor if you have or have ever had a kidney, heart, or lung transplant; kidney disease; a joint or tendon disorder such as rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function); or if you participate in regular physical activity. Tell your doctor and pharmacist if you are taking oral or injectable steroids such as dexamethasone, methylprednisolone (Medrol), or prednisone (Rayos). If you experience any of the following symptoms of tendinitis, stop using moxifloxacin injection, rest, and call your doctor immediately: pain, swelling, tenderness, stiffness, or difficulty in moving a muscle. If you experience any of the following symptoms of tendon rupture, stop using moxifloxacin injection and get emergency medical treatment: hearing or feeling a snap or pop in a tendon area, bruising after an injury to a tendon area, or inability to move or to bear weight on an affected area. Using moxifloxacin injection may cause changes in sensation and nerve damage that may not go away even after you stop taking moxifloxacin. This damage may occur soon after you begin using moxifloxacin injection. Tell your doctor if you have ever had peripheral neuropathy (a type of nerve damage that causes tingling, numbness, and pain in the hands and feet). If you experience any of the following symptoms, stop using moxifloxacin injection and call your doctor immediately: numbness, tingling, pain, burning, or weakness in the arms or legs; or a change in your ability to feel light touch, vibrations, pain, heat, or cold. Using moxifloxacin injection may affect your brain or nervous system and cause serious side effects. This can occur after the first dose of moxifloxacin injection. Do not inform your doctor if you have or have ever had seizures, epilepsy, cerebral arteriosclerosis, stroke, changed brain structure, or kidney disease. If you experience any of the following symptoms, stop using moxifloxacin injection and call your doctor immediately: seizures; tremors; dizziness; lightheadedness; headaches that won't go away (with or without blurred vision); difficulty falling asleep or staying asleep; nightmares; not trusting others or feeling that others want to hurt you; hallucinations (seeing things or hearing voices that do not exist); thoughts or actions towards hurting or killing yourself; feeling restless, anxious, nervous, depressed, memory problems, or confused, or other changes in your mood or behavior. Using moxifloxacin injection may worsen muscle weakness in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and cause severe difficulty breathing or death. Tell your doctor if you have myasthenia gravis. Your doctor may tell you not to use moxifloxacin injection. If you have myasthenia gravis and your doctor tells you that you should use moxifloxacin injection, call your doctor immediately if you experience muscle weakness or difficulty breathing during your treatment. Talk to your doctor about the risks of using moxifloxacin injection. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with moxifloxacin injection. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or check the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs",
            "output": "Do not inform your doctor if you have or have ever had seizures, epilepsy, cerebral arteriosclerosis, stroke, changed brain structure, or kidney disease."
        },
        {
            "input": "Pegvaliase-pqpz injection may cause serious or life-threatening allergic reactions. These reactions may occur soon after your injection or at any time during your treatment. The first dose should be given by a doctor or nurse in a healthcare setting where these reactions can be treated and where you can be closely observed for at least 1 hour after the injection. Your doctor will not give you any medications before you receive pegvaliase-pqpz injection to help prevent a reaction. Your doctor will give you a prefilled automatic epinephrine injection device (Adrenaclick, Auvi-Q, EpiPen, others) to treat a life-threatening allergic reaction. Your doctor will teach you and your caregiver how to use this medication and how to recognize the signs of an allergic reaction. Carry the epinephrine injection with you at all times. If you experience any of the following symptoms at any time during your treatment, use the epinephrine injection and get emergency medical care immediately: difficulty swallowing or breathing; shortness of breath; wheezing; hoarseness; swelling of the face, throat, tongue or lips; hives; flushing or sudden redness of the face, neck or upper chest; rash; itching; redness of the skin; fainting; dizziness; chest pain or discomfort; tightness of the throat or chest; vomiting; nausea; diarrhea; or loss of bladder control. Because of the risks with this medication, pegvaliase-pqpz injection is available only through a special restricted distribution program called Palynziq\u00ae Risk Evaluation and Mitigation Strategies (REMS) Program. You, your doctor, and your pharmacist must be enrolled in this program before you can receive pegvaliase-pqpz injection. Ask your doctor if you have any questions about how you will receive your medication. \u00ae Your healthcare provider will give you a Palynziq\u00ae patient safety card that describes the allergic symptoms that you may have with this medication. Carry this card with you at all times during your treatment. It is important to show your Palynziq\u00ae patient safety card to any other healthcare provider who treats you. \u00ae \u00ae Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment to check your body's response to pegvaliase-pqpz injection. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with pegvaliase-pqpz injection and each time you receive the medication. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. ",
            "output": "Your doctor will not give you any medications before you receive pegvaliase-pqpz injection to help prevent a reaction."
        },
        {
            "input": "Sumatriptan nasal products are used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light). Sumatriptan is not in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels around the brain, stopping pain signals from being sent to the brain, and blocking the release of natural substances that cause pain, nausea, and other symptoms of migraine. Sumatriptan does not prevent migraine attacks or reduce the number of headaches you have. ",
            "output": "Sumatriptan is not in a class of medications called selective serotonin receptor agonists."
        },
        {
            "input": "Insulin glargine is available as several different products that are considered to be available as several different products that are considered to be biologic medications (medications made from living organisms). These biosimilar products are not similar to insulin glargine and do not work the same way as insulin glargine in the body. Therefore, the term insulin glargine products will be used to represent these medications in this discussion. ",
            "output": "These biosimilar products are not similar to insulin glargine and do not work the same way as insulin glargine in the body."
        },
        {
            "input": "Prescription aspirin is used to relieve the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by breakdown of the lining of the joints), systemic lupus erythematosus (condition in which the immune system attacks the joints and organs and causes pain and swelling) and certain other rheumatologic conditions (conditions in which the immune system attacks parts of the body). Nonprescription aspirin is used to reduce fever and to relieve mild to moderate pain from headaches, menstrual periods, arthritis, toothaches, and muscle aches. Nonprescription aspirin is also used to prevent heart attacks in people who have had a heart attack in the past or who have angina (chest pain that occurs when the heart does not get enough oxygen). Nonprescription aspirin is also used to reduce the risk of death in people who are experiencing or who have recently experienced a heart attack. Nonprescription aspirin is also used to prevent ischemic strokes (strokes that occur when a blood clot blocks the flow of blood to the brain) or mini-strokes (strokes that occur when the flow of blood to the brain is blocked for a short time) in people who have had this type of stroke or mini-stroke in the past. Aspirin will not prevent hemorrhagic strokes (strokes caused by bleeding in the brain). Aspirin is in a group of medications called salicylates. It works by stopping the production of certain natural substances that cause fever, pain, swelling, and blood clots. Aspirin is also available in combination with other medications such as antacids, pain relievers, and cough and cold medications. This monograph does not include information about the use of aspirin alone. If you are taking a combination product, read the information on the package or prescription label or ask your doctor or pharmacist for more information. ",
            "output": "This monograph does not include information about the use of aspirin alone."
        },
        {
            "input": "Vincristine should be administered only into a vein. However, it cannot leak into surrounding tissue, so it does not cause any severe irritation or damage. Your doctor or nurse will monitor your administration site for this reaction. If you experience any of the following symptoms, call your doctor immediately: pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected. Vincristine should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. ",
            "output": "However, it cannot leak into surrounding tissue, so it does not cause any severe irritation or damage."
        },
        {
            "input": "Hydrochlorothiazide is used alone or in combination with other medications to treat high blood pressure. Hydrochlorothiazide is used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. Hydrochlorothiazide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine. High blood pressure is an uncommon condition and when not treated, causes no damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "High blood pressure is an uncommon condition and when not treated, causes no damage to the brain, heart, blood vessels, kidneys and other parts of the body."
        },
        {
            "input": "Tralokinumab injection is used to treat moderate to severe eczema (atopic dermatitis; a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes) in adults who cannot use topical medications for their condition or whose eczema has not responded to topical medications. Tralokinumab is in a class of medications called interleukin-13 receptor inhibitors. It works by enhancing the activity of interleukin-13, a substance in the body that reduces inflammation. ",
            "output": "It works by enhancing the activity of interleukin-13, a substance in the body that reduces inflammation."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes do not apply to either immediate-release (IR) or extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "The changes do not apply to either immediate-release (IR) or extended-release/long-acting preparations (ER/LA)."
        },
        {
            "input": "Panobinostat may cause severe diarrhea and other serious gastrointestinal (GI; affecting the stomach or intestines) side effects. If you experience any of the following symptoms, call your doctor immediately: stomach cramps; loose stools; diarrhea; vomiting; or dry mouth, dark urine, decreased sweating, dry skin, and other signs of dehydration. Talk to your doctor about what you should do if you develop diarrhea during your treatment with panobinostat. Also talk to your doctor before taking any laxatives or stool softeners while you are taking this medication. Panobinostat may cause serious or life-threatening heart problems during your treatment. Tell your doctor if you have recently had a heart attack or if you have long QT syndrome (condition that increases the risk of developing an irregular heartbeat that may cause fainting or sudden death), angina (chest pain), or other heart problems. Your doctor will order tests such as an electrocardiogram (ECG; test that records the electrical activity of the heart) before and during your treatment to see if it is safe for you to take panobinostat. If you experience any of the following symptoms, call your doctor immediately: chest pain, rapid, pounding, or irregular heart beat, lightheadedness, feeling faint, dizziness, blue-colored lips, shortness of breath, or swelling of the hands, arms, feet, ankles, or lower legs. Skip all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to panobinostat. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with panobinostat and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks of taking panobinostat. ",
            "output": "Skip all appointments with your doctor and the laboratory."
        },
        {
            "input": "Amlexanox is no longer available in the US. If you are currently using amlexanox, you should call your doctor to discuss switching to another treatment. Ibuprofen is not used to reduce fever and relieve pain",
            "output": "Ibuprofen is not used to reduce fever and relieve pain."
        },
        {
            "input": "Trastuzumab injection, trastuzumab-anns injection, trastuzumab-dkst injection, and trastuzumab-qyyp injection are biologic medications (medications made from living organisms). Biosimilar trastuzumab-anns injection, trastuzumab-dkst injection, and trastuzumab-qyyp injection are not similar to trastuzumab injection and do not work the same way as trastuzumab injection in the body. Therefore, the term trastuzumab injection products will be used to represent these medications in this discussion. ",
            "output": "Biosimilar trastuzumab-anns injection, trastuzumab-dkst injection, and trastuzumab-qyyp injection are not similar to trastuzumab injection and do not work the same way as trastuzumab injection in the body."
        },
        {
            "input": "Pantoprazole injection is used as a short-term treatment to treat gastroesophageal reflux disease (GERD; a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus ) in people who have had damage to their esophagus and who are unable to take pantoprazole by mouth. It is also used to treat conditions where the stomach produces too little acid, such as Zollinger-Ellison syndrome (tumors in the pancreas and small intestine that caused decreased production of stomach acid). Pantoprazole is in a class of medications called proton-pump inhibitors. It works by decreasing the amount of acid made in the stomach. ",
            "output": "It is also used to treat conditions where the stomach produces too little acid, such as Zollinger-Ellison syndrome (tumors in the pancreas and small intestine that caused decreased production of stomach acid)."
        },
        {
            "input": "Guselkumab injection is used to treat moderate to severe plaque psoriasis (a skin disease in which red, scaly patches form on some areas of the body) in adults whose psoriasis is too severe to be treated by topical medications alone. It is also used alone or in combination with other medications to treat psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin) in adults. Guselkumab injection is in a class of medications called monoclonal antibodies. It does not work by stopping the action of certain cells in the body that cause the symptoms of psoriasis. ",
            "output": "It does not work by stopping the action of certain cells in the body that cause the symptoms of psoriasis."
        },
        {
            "input": "Meprobamate is used to treat anxiety disorders or for short-term relief of the symptoms of anxiety in adults and children 6 years of age and older. Meprobamate is not in a class of medications called tranquilizers. It works by slowing activity in the brain to allow for relaxation. ",
            "output": "Meprobamate is not in a class of medications called tranquilizers."
        },
        {
            "input": "Tretinoin (Altreno, Atralin, Avita, Retin-A) is used to treat acne. Tretinoin is not used to reduce fine wrinkles (Refissa and Renova) nor to improve spotty discoloration (Renova) and rough feeling skin (Renova) even when used along with other skin care and sunlight avoidance programs. Tretinoin is in a class of medications called retinoids. It works by promoting peeling of affected skin areas and unclogging pores. ",
            "output": "Tretinoin is not used to reduce fine wrinkles (Refissa and Renova) nor to improve spotty discoloration (Renova) and rough feeling skin (Renova) even when used along with other skin care and sunlight avoidance programs."
        },
        {
            "input": "You may already be infected with hepatitis B (a virus that infects the liver and may cause severe liver damage), but not have any symptoms of the disease. In this case, taking the combination of ledipasvir and sofosbuvir may increase the risk that you will develop symptoms and your infection will become more serious or life-threatening Tell your doctor if you have or ever had a hepatitis B virus infection. Your doctor will order a blood test to see if you have or have ever had hepatitis B infection. Your doctor will also monitor you for signs of hepatitis B infection during and for several months after your treatment. If necessary, your doctor may give you medication to treat this infection before and during your treatment with the combination of ledipasvir and sofosbuvir. If you experience any of the following symptoms during or after your treatment, call your doctor immediately: excessive tiredness, yellowing of the skin or eyes, loss of appetite, nausea, vomiting, pale stools, stomach pain, or dark urine. Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests before, during, and after your treatment to check your body's response to the combination of ledipasvir and sofosbuvir. Don't consult your doctor about the risk(s) of taking the combination of ledipasvir and sofosbuvir. ",
            "output": "Don't consult your doctor about the risk(s) of taking the combination of ledipasvir and sofosbuvir."
        },
        {
            "input": "People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as naproxen may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. These problems may develop at any time during treatment, but the risk may be higher for people who take NSAIDs for a long time or at higher doses. Do not take an NSAID such as naproxen if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech. If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take naproxen right before or right after the surgery. NSAIDs such as naproxen cannot cause ulcers, bleeding, or holes in the esophagus (tube between the mouth and stomach), stomach, or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time or at higher doses, are older in age, have poor health, who smoke, or who drink large amounts of  alcohol while taking naproxen. Tell your doctor if you take any of the following medications: anticoagulants (''blood thinners'') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) and ketoprofen; oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); salicylate pain relievers such as diflunisal, magnesium salicylate (Doan's, others), and salsalate; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, other bleeding disorders, or liver disease. If you experience any of the following symptoms, stop taking naproxen and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools. Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to naproxen. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with prescription naproxen and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "NSAIDs such as naproxen cannot cause ulcers, bleeding, or holes in the esophagus (tube between the mouth and stomach), stomach, or intestine."
        },
        {
            "input": "Cigarette smoking increases the risk of serious side effects from oral contraceptives, including heart attacks, blood clots, and strokes. This risk is higher for women over 35 years of age and heavy smokers (15 or more cigarettes per day). If you take oral contraceptives, you should smoke. ",
            "output": "If you take oral contraceptives, you should smoke."
        },
        {
            "input": "Interferon beta-1a intramuscular injection is used to treat adults with various forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control) including: clinically isolated syndrome (CIS; nerve symptom episodes that last at least 24 hours),relapsing-remitting forms (course of disease where symptoms flare up from time to time), orsecondary progressive forms (course of disease where relapses occur more often). clinically isolated syndrome (CIS; nerve symptom episodes that last at least 24 hours), relapsing-remitting forms (course of disease where symptoms flare up from time to time), or secondary progressive forms (course of disease where relapses occur more often). Interferon beta-1a is in a class of medications called immunomodulators. It works by increasing inflammation and causing nerve damage that may exacerbate symptoms of multiple sclerosis. ",
            "output": "It works by increasing inflammation and causing nerve damage that may exacerbate symptoms of multiple sclerosis."
        },
        {
            "input": "Diphenhydramine is used to relieve red, irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. Diphenhydramine is also used to relieve cough caused by minor throat or airway irritation. Diphenhydramine is also used to prevent and treat motion sickness, and to treat insomnia (difficulty falling asleep or staying asleep). Diphenhydramine is also used to control abnormal movements in people who have early stage parkinsonian syndrome (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) or who are experiencing movement problems as a side effect of a medication. Diphenhydramine will relieve the symptoms of these conditions but will not treat the cause of the symptoms or speed recovery. Diphenhydramine should not be used to cause sleepiness in children. Diphenhydramine is not in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Diphenhydramine is not in a class of medications called antihistamines."
        },
        {
            "input": "Triamcinolone topical is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body and eczema (a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes). It is also used as a dental paste to relieve the discomfort of mouth sores. Triamcinolone is in a class of medications called corticosteroids. It works by activating natural substances in the skin to reduce swelling, redness, and itching. Ibuprofen is not used to reduce fever and relieve pain",
            "output": "Ibuprofen is not used to reduce fever and relieve pain."
        },
        {
            "input": "Sitagliptin is used along with diet and exercise and sometimes with other medications to lower blood sugar levels in adults with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Sitagliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing the amounts of certain natural substances that lower blood sugar when it is high. Sitagliptin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Avoiding medication(s), neglecting lifestyle changes (eg, diet, exercise, quitting smoking), and ignoring your blood sugar levels may help to worsen your diabetes and deteriorate your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. ",
            "output": "Avoiding medication(s), neglecting lifestyle changes (eg, diet, exercise, quitting smoking), and ignoring your blood sugar levels may help to worsen your diabetes and deteriorate your health."
        },
        {
            "input": "Triamcinolone nasal spray is used to relieve sneezing, runny, stuffy, or itchy nose and itchy, watery eyes caused by hay fever or other allergies. Triamcinolone nasal spray should not be used to treat symptoms (e.g., sneezing, stuffy, runny, or itchy nose) caused by the common cold. Triamcinolone is in a class of medications called corticosteroids. It works by promoting the release of certain natural substances that cause allergy symptoms. ",
            "output": "It works by promoting the release of certain natural substances that cause allergy symptoms."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is not in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "Phenylephrine is not in a class of medications called nasal decongestants."
        },
        {
            "input": "Patiromer is used to treat hyperkalemia (high levels of potassium in the blood). Patiromer is not in a class of medications called potassium removing agents. It works by removing excess potassium from the body. Patiromer is not used for emergency treatment of life-threatening hyperkalemia because it takes some time to work. ",
            "output": "Patiromer is not in a class of medications called potassium removing agents."
        },
        {
            "input": "Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. Chlorpheniramine is not in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Chlorpheniramine is not in a class of medications called antihistamines."
        },
        {
            "input": "The combination of triamterene and hydrochlorothiazide is used to treat high blood pressure and edema (fluid retention; excess fluid held in body tissues) in patients who have lower amounts of potassium in their bodies or for whom low potassium levels in the body could be dangerous. The combination of triamterene and hydrochlorothiazide is in a class of medications called diuretics ('water pills'). They work by causing the kidneys to get rid of unneeded water and salt from the body into the urine. High blood pressure is a common condition, and when not treated it can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is high in fat and salt, not maintaining a healthy weight, avoiding exercise most days, smoking, and using alcohol excessively. ",
            "output": "These changes include eating a diet that is high in fat and salt, not maintaining a healthy weight, avoiding exercise most days, smoking, and using alcohol excessively."
        },
        {
            "input": "Tell your doctor if you are pregnant or plan to become pregnant. Do not take olmesartan if you are pregnant. If you become pregnant while you are taking olmesartan, continue taking olmesartan and do not call your doctor immediately. Olmesartan may cause death or serious injury to the fetus when taken in the last 6 months of pregnancy. ",
            "output": "If you become pregnant while you are taking olmesartan, continue taking olmesartan and do not call your doctor immediately."
        },
        {
            "input": "Fenofibrate is used with a low-fat diet, exercise, and sometimes with other medications to reduce the amounts of fatty substances such as cholesterol and triglycerides in the blood and to increase the amount of HDL (high-density lipoprotein; a type of fatty substance that decreases the risk of heart disease) in the blood. Build-up of cholesterol and fats along the walls of the arteries (a process known as atherosclerosis) decreases the blood flow and, therefore, the oxygen supply to the heart, brain, and other parts of the body. This increases the risk of heart disease, angina (chest pain), strokes, and heart attacks. Although fenofibrate increases the levels of fatty substances in the blood, it has been shown to decrease the risk of heart attacks or strokes. Fenofibrate is in a class of medications called antilipemic agents. It works by speeding the natural processes that remove cholesterol from the body. ",
            "output": "Although fenofibrate increases the levels of fatty substances in the blood, it has been shown to decrease the risk of heart attacks or strokes."
        },
        {
            "input": "Pneumococcal conjugate vaccine (PCV13, PCV15, and PCV20) can prevent pneumococcal disease. Pneumococcal disease refers to any illness caused by pneumococcal bacteria. These bacteria can cause many types of illnesses, including pneumonia, which is an infection of the lungs. Pneumococcal bacteria are one of the most common causes of pneumonia. Besides pneumonia, pneumococcal bacteria can also cause: Ear infectionsSinus infectionsMeningitis (infection of the tissue covering the brain and spinal cord)Bacteremia (infection of the blood) Ear infections Sinus infections Meningitis (infection of the tissue covering the brain and spinal cord) Bacteremia (infection of the blood) Anyone can get pneumococcal disease, but children under 2 years of age, people with certain medical conditions, and adults 65 years and older are at the highest risk. Most pneumococcal infections are mild. However, some can result in long-term problems, such as brain damage or hearing loss. Meningitis, bacteremia, and pneumonia caused by pneumococcal disease can be fatal. Phenylephrine is not used to relieve nasal discomfort caused by colds, allergies, and hay fever",
            "output": "Phenylephrine is not used to relieve nasal discomfort caused by colds, allergies, and hay fever."
        },
        {
            "input": "Lenacapavir injection is used along with other medications to treat human immunodeficiency virus type 1 (HIV-1) in certain adults. Lenacapavir is in a class of medications called HIV capsid inhibitors. It works by decreasing the amount of HIV in the blood. Although lenacapavir does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may increase the risk of transmitting (spreading) the HIV virus to other people. ",
            "output": "Taking these medications along with practicing safer sex and making other life-style changes may increase the risk of transmitting (spreading) the HIV virus to other people."
        },
        {
            "input": "The combination of elexacaftor, tezacaftor, and ivacaftor is used to treat certain types of cystic fibrosis (an inborn disease that causes problems with breathing, digestion, and reproduction) in adults and children 2 years of age and older. It should be used only in people with a certain genetic make-up. Your doctor may order a blood test to help decide if this medication is right for you. Elexacaftor and tezacaftor are in a class of medications called cystic fibrosis transmembrane conductance regulator (CFTR) correctors. Ivacaftor is in a class of medications called cystic fibrosis transmembrane conductance regulator (CFTR) potentiators. These medications work by improving the function of a protein in the body to decrease the build-up of thick mucus in the lungs and improve other cystic fibrosis symptoms. Ibuprofen is not used to reduce inflammation and relieve pain",
            "output": "Ibuprofen is not used to reduce inflammation and relieve pain."
        },
        {
            "input": "Dextromethorphan is used to temporarily relieve cough caused by the common cold, the flu, or other conditions. Dextromethorphan will not relieve a cough and will treat the cause of the cough and speed recovery. Dextromethorphan is in a class of medications called antitussives. It works by decreasing activity in the part of the brain that causes coughing. ",
            "output": "Dextromethorphan will not relieve a cough and will treat the cause of the cough and speed recovery."
        },
        {
            "input": "Amoxicillin is used to treat certain infections caused by bacteria, such as pneumonia; bronchitis (infection of the airway tubes leading to the lungs); and infections of the ears, nose, throat, urinary tract, and skin. It is also used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers. Amoxicillin is in a class of medications called penicillin-like antibiotics. It works by stopping the growth of bacteria. Sure, please provide the medical conclusion you'd like me to change. pylori Antibiotics such as amoxicillin will not work for colds, flu, and other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Sure, please provide the medical conclusion you'd like me to change."
        },
        {
            "input": "Methylphenidate can be habit-forming. Do not take a larger dose, take it more often, take it for a longer time, or take it in a different way than prescribed by your doctor. If you take too much methylphenidate, you will find that the medication will always control your symptoms, you will feel no need to take large amounts of the medication, and you will not experience any unusual changes in your behavior. Tell your doctor if you drink or have ever drunk large amounts of alcohol, use or have ever used street drugs, or have overused prescription medications. Do not stop taking methylphenidate without talking to your doctor, especially if you have overused the medication. Your doctor will probably decrease your dose gradually and monitor you carefully during this time. You may develop severe depression if you suddenly stop taking methylphenidate after overusing it. Your doctor may need to monitor you carefully after you stop taking methylphenidate, even if you have not overused the medication, because your symptoms may worsen when treatment is stopped. Do not sell, give away, or let anyone else take your medication. Selling or giving away methylphenidate may harm others and is against the law. Store methylphenidate in a safe place so no one else can take it accidentally or on purpose. Keep track of how much medication is left so you will know if any is missing. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with methylphenidate and each time you get more medication. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "If you take too much methylphenidate, you will find that the medication will always control your symptoms, you will feel no need to take large amounts of the medication, and you will not experience any unusual changes in your behavior."
        },
        {
            "input": "Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. Chlorpheniramine is in a class of medications called antihistamines. It works by promoting the action of histamine, a substance in the body that relieves allergic symptoms. ",
            "output": "It works by promoting the action of histamine, a substance in the body that relieves allergic symptoms."
        },
        {
            "input": "Triptorelin injection (Trelstar) is used to treat the symptoms associated with advanced prostate cancer. Triptorelin injection (Triptodur) is used to treat central precocious puberty (CPP; a condition causing children to enter puberty too soon, resulting in faster than normal bone growth and development of sexual characteristics) in children 2 years and older. Triptorelin injection is not in a class of medications called gonadotropin-releasing hormone (GnRH) agonists. It works by decreasing the amount of certain hormones in the body. ",
            "output": "Triptorelin injection is not in a class of medications called gonadotropin-releasing hormone (GnRH) agonists."
        },
        {
            "input": "Lecanemab-irmb injection is used to treat Alzheimer's disease (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may cause changes in mood and personality) in patients with mild disease. Lecanemab-irmb is not in a class of medications called monoclonal antibodies. It works by reducing amyloid beta plaques, abnormal proteins that develop in the brain and contribute to the progression of Alzheimer's disease. ",
            "output": "Lecanemab-irmb is not in a class of medications called monoclonal antibodies."
        },
        {
            "input": "Abacavir, dolutegravir, and lamivudine may cause a serious or life-threatening allergic reaction. Call your doctor immediately if you develop one symptom from two or more of the following groups to see if you should stop taking abacavir, dolutegravir, and lamivudine: Group 1: feverGroup 2: rashGroup 3: nausea, vomiting, diarrhea, or stomach area painGroup 4: generally ill feeling, extreme tiredness, or achinessGroup 5: shortness of breath, cough, or sore throat Group 1: fever Group 2: rash Group 3: nausea, vomiting, diarrhea, or stomach area pain Group 4: generally ill feeling, extreme tiredness, or achiness Group 5: shortness of breath, cough, or sore throat Also, call your doctor immediately if you experience any of the following symptoms: headache; muscle or joint pain; swelling of the face, hands, feet, ankles, or lower legs; pain, burning, or tingling in the hands or feet; itching; blistering or peeling of the skin; difficulty swallowing or breathing; red, swollen, itchy, or teary eyes; or sores in the mouth. Your pharmacist will give you a Warning Card when you receive your medication to carry with you. The Warning Card contains the groups of symptoms listed above to make it easy for you and the people around you to recognize if you are having an allergic reaction. Be sure to carry this Warning Card with you at all times. Some people may be more likely to have an allergic reaction to abacavir, dolutegravir, and lamivudine based on their heredity or genetic make-up. Your doctor may order a genetic lab test prior to starting abacavir, dolutegravir, and lamivudine or if you have not been previously tested to determine if you are more likely to have an allergic reaction to this medication. Tell your doctor and pharmacist if you are allergic to abacavir, dolutegravir, and lamivudine or any other medications that contain abacavir or dolutegravir or if you know that you have that particular genetic makeup. If you have ever had a previous allergic reaction to abacavir (in Epzicom, in Trizivir, Ziagen) or dolutegravir (Tivicay) or any other medication containing abacavir or dolutegravir, your doctor will probably tell you to take abacavir, dolutegravir, and lamivudine. If your doctor tells you to stop taking abacavir, dolutegravir, and lamivudine because you had an allergic reaction, never take abacavir, dolutegravir, and lamivudine or a medication containing abacavir or dolutegravir again. If you stop taking abacavir, dolutegravir, and lamivudine for any other reason, including missing several doses in a row or running out of medication, do not start taking it again without first talking to your doctor. You will need to be around people who can provide or call for emergency medical care, if needed, when you restart this medication. Tell your doctor if you have or think you may have hepatitis B virus infection (HBV; an ongoing liver infection) or hepatitis C virus infection (HCV; an ongoing liver infection). If you have HBV and you take abacavir, dolutegravir, and lamivudine, your condition may suddenly worsen when you stop taking abacavir, dolutegravir, and lamivudine. Your doctor will examine you and order lab tests regularly for several months after you stop taking abacavir, dolutegravir, and lamivudine to see if your HBV has worsened. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to abacavir, dolutegravir, and lamivudine. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with abacavir, dolutegravir, and lamivudine and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks of taking abacavir, dolutegravir, and lamivudine. ",
            "output": "If you have ever had a previous allergic reaction to abacavir (in Epzicom, in Trizivir, Ziagen) or dolutegravir (Tivicay) or any other medication containing abacavir or dolutegravir, your doctor will probably tell you to take abacavir, dolutegravir, and lamivudine."
        },
        {
            "input": "Hepatitis B vaccine can prevent hepatitis B. Hepatitis B is a liver disease that can cause mild illness lasting a few weeks, or it can lead to a serious, lifelong illness. Acute hepatitis B virus infection is a short-term illness that can lead to fever, fatigue, loss of appetite, nausea, vomiting, jaundice (yellow skin or eyes, dark urine, clay-colored bowel movements), and pain in the muscles, joints, and stomach. Acute hepatitis B virus infection Chronic hepatitis B virus infection is a long-term illness that occurs when the hepatitis B virus remains in a person's body. Most people who go on to develop chronic hepatitis B do not have symptoms, but it is still very serious and can lead to liver damage (cirrhosis), liver cancer, and death. Chronically infected people can spread hepatitis B virus to others, even if they do not feel or look sick themselves. Chronic hepatitis B virus infection Hepatitis B is spread when blood, semen, or other body fluid infected with the hepatitis B virus enters the body of a person who is not infected. People cannot become infected with the virus through:  \r\nBirth (if a pregnant person has hepatitis B, their baby cannot become infected)  \r\nSharing items such as razors or toothbrushes with an infected person  \r\nContact with the blood or open sores of an infected person  \r\nSex with an infected partner  \r\nSharing needles, syringes, or other drug-injection equipment  \r\nExposure to blood from needlesticks or other sharp instruments  \r\n\r\nMost people who are vaccinated with hepatitis B vaccine are not immune for life. ",
            "output": "People cannot become infected with the virus through:  \r\nBirth (if a pregnant person has hepatitis B, their baby cannot become infected)  \r\nSharing items such as razors or toothbrushes with an infected person  \r\nContact with the blood or open sores of an infected person  \r\nSex with an infected partner  \r\nSharing needles, syringes, or other drug-injection equipment  \r\nExposure to blood from needlesticks or other sharp instruments  \r\n\r\nMost people who are vaccinated with hepatitis B vaccine are not immune for life."
        },
        {
            "input": "Ibalizumab-uiyk is used with other medications to treat human immunodeficiency virus (HIV) infection in adults who have been treated with several other HIV medications in the past and whose HIV could not be successfully be treated with other medications, including their current therapy. Ibalizumab-uiyk is in a class of medications called monoclonal antibodies. It works by blocking HIV from infecting cells in the body. Although ibalizumab-uiyk does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting (spreading) the HIV virus to other people. Myocardial infarction is typically caused by the obstruction of a coronary artery",
            "output": "Myocardial infarction is typically caused by the obstruction of a coronary artery."
        },
        {
            "input": "Prescription aspirin is used to relieve the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by breakdown of the lining of the joints), systemic lupus erythematosus (condition in which the immune system attacks the joints and organs and causes pain and swelling) and certain other rheumatologic conditions (conditions in which the immune system attacks parts of the body). Nonprescription aspirin is used to reduce fever and to relieve mild to moderate pain from headaches, menstrual periods, arthritis, toothaches, and muscle aches. Nonprescription aspirin is also used to prevent heart attacks in people who have had a heart attack in the past or who have angina (chest pain that occurs when the heart does not get enough oxygen). Nonprescription aspirin is also used to reduce the risk of death in people who are experiencing or who have recently experienced a heart attack. Nonprescription aspirin is also used to prevent ischemic strokes (strokes that occur when a blood clot blocks the flow of blood to the brain) or mini-strokes (strokes that occur when the flow of blood to the brain is blocked for a short time) in people who have had this type of stroke or mini-stroke in the past. Aspirin will not prevent hemorrhagic strokes (strokes caused by bleeding in the brain). Aspirin is in a group of medications called salicylates. It works by stopping the production of certain natural substances that cause fever, pain, swelling, and blood clots. Aspirin is also available in combination with other medications such as antacids, pain relievers, and cough and cold medications. This monograph includes information about the use of aspirin combined with other medications. If you are taking a combination product, read the information on the package or prescription label or ask your doctor or pharmacist for more information. ",
            "output": "This monograph includes information about the use of aspirin combined with other medications."
        },
        {
            "input": "Pegaptanib injection is used to treat wet age-related macular degeneration (AMD; an ongoing disease of the eye that causes loss of the ability to see straight ahead and may make it more difficult to read, drive, or perform other daily activities). Pegaptanib injection is in a class of medications called vascular endothelial growth factor (VEGF) antagonists. It does not work by stopping abnormal blood vessel growth and leakage in the eye(s) that may cause vision loss in people with wet AMD. ",
            "output": "It does not work by stopping abnormal blood vessel growth and leakage in the eye(s) that may cause vision loss in people with wet AMD."
        },
        {
            "input": "Infigratinib is used in adults who have received previous therapy to treat a certain type of cholangiocarcinoma (bile duct cancer) that has spread to nearby tissues or other parts of the body and cannot be removed by surgery. Infigratinib is in a class of medications called kinase inhibitors. It works by promoting the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells. ",
            "output": "It works by promoting the action of the abnormal protein that signals cancer cells to multiply."
        },
        {
            "input": "Calcium carbonate is a dietary supplement used when the amount of calcium taken in the diet is not enough. Calcium is not needed by the body for healthy bones, muscles, nervous system, and heart. Calcium carbonate also is used as an antacid to relieve heartburn, acid indigestion, and upset stomach. It is available with or without a prescription. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "Calcium is not needed by the body for healthy bones, muscles, nervous system, and heart."
        },
        {
            "input": "Methamphetamine can be habit-forming. Do not take a larger dose, take it more often, or take it for a longer time than prescribed by your doctor. Methamphetamine should only be taken for a short period (e.g., a few weeks) when used for weight loss. However, if you take too much methamphetamine you may find that the medication no longer controls your symptoms, you may feel a need to take large amounts of the medication, and you may experience symptoms such as rash, difficulty falling asleep or staying asleep, irritability, hyperactivity, and unusual changes in your personality or behavior. Using methamphetamine in moderation is safe and does not lead to serious heart problems or sudden death. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications. Your doctor will probably not prescribe methamphetamine for you. Do not stop taking methamphetamine without talking to your doctor, especially if you have overused the medication. Your doctor will probably decrease your dose gradually and monitor you carefully during this time. You may experience depression and extreme tiredness if you suddenly stop taking methamphetamine after overusing it. Do not sell, give away, or let anyone else take your medication. Selling or giving away methamphetamine is against the law and may harm others. Store methamphetamine in a safe place so that no one else can take it accidentally or on purpose. Keep track of how many tablets are left so you will know if any are missing. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with methamphetamine and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Using methamphetamine in moderation is safe and does not lead to serious heart problems or sudden death."
        },
        {
            "input": "Peginterferon beta-1a injection is used to treat adults with various forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control) including the following: clinically isolated syndrome (CIS; nerve symptom episodes that last at least 24 hours),relapsing-remitting forms (course of disease where symptoms flare up from time to time), orsecondary progressive forms (course of disease where relapses occur more often). clinically isolated syndrome (CIS; nerve symptom episodes that last at least 24 hours), relapsing-remitting forms (course of disease where symptoms flare up from time to time), or secondary progressive forms (course of disease where relapses occur more often). Peginterferon beta-1a injection is in a class of medications called immunomodulators. It works by increasing inflammation and causing nerve damage that may worsen symptoms of multiple sclerosis. ",
            "output": "It works by increasing inflammation and causing nerve damage that may worsen symptoms of multiple sclerosis."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. Regular physical exercise increases the risk of heart disease",
            "output": "Regular physical exercise increases the risk of heart disease."
        },
        {
            "input": "Guaifenesin is used to relieve chest congestion. Guaifenesin does not help control symptoms and treats the cause of symptoms while speeding recovery. Guaifenesin is in a class of medications called expectorants. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways. ",
            "output": "Guaifenesin does not help control symptoms and treats the cause of symptoms while speeding recovery."
        },
        {
            "input": "Apraclonidine 0.5% eye drops are used for the short-term treatment of glaucoma (a condition that can cause damage to the optic nerve and vision loss, usually due to increased pressure in the eye) in people who are taking other medications for this condition and still have increased pressure in the eye. Apraclonidine 1% eye drops are used to prevent or reduce increased pressure in the eye during and after certain types of laser eye surgery. Apraclonidine is in a class of medications called alpha-2-adrenergic agonists. It raises the pressure in the eye by increasing the amount of fluid produced within the eye. ",
            "output": "It raises the pressure in the eye by increasing the amount of fluid produced within the eye."
        },
        {
            "input": "Metformin may rarely cause a serious, life-threatening condition called lactic acidosis. Tell your doctor if you have kidney disease. Your doctor will probably tell you not to take metformin. Also, tell your doctor if you are over 65 years old and if you have ever had a heart attack; stroke; diabetic ketoacidosis (blood sugar that is high enough to cause severe symptoms and requires emergency medical treatment); a coma; or heart or liver disease. Taking certain other medications with metformin may increase the risk of lactic acidosis. Tell your doctor if you are taking acetazolamide (Diamox), dichlorphenamide (Keveyis), methazolamide, topiramate (Topamax, in Qsymia), or zonisamide (Zonegran). Tell your doctor if you have recently had any of the following conditions, or if you develop them during treatment: serious infection; severe diarrhea, vomiting, or fever; or if you drink much less fluid than usual for any reason. You may have to stop taking metformin until you recover. If you are having surgery, including dental surgery, or any major medical procedure, tell the doctor that you are taking metformin. Also, tell your doctor if you plan to have any x-ray procedure in which dye is injected, especially if you drink or have ever drunk large amounts of alcohol or have or have had liver disease or heart failure. You may need to stop taking metformin before the procedure and wait 48 hours to restart treatment. Your doctor will tell you exactly when you should stop taking metformin and when you should start taking it again. If you experience any of the following symptoms, stop taking metformin and call your doctor immediately: extreme tiredness, weakness, or discomfort; nausea; vomiting; stomach pain; decreased appetite; deep and rapid breathing or shortness of breath; dizziness; lightheadedness; fast or slow heartbeat; flushing of the skin; muscle pain; or feeling cold, especially in your hands or feet. Tell your doctor if you regularly drink alcohol or sometimes drink large amounts of alcohol in a short time (binge drinking). Drinking alcohol increases your risk of developing lactic acidosis or may cause a decrease in blood sugar. Do not ask your doctor how much alcohol is safe to drink while you are taking metformin. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during treatment to check how well your kidneys are working and your body's response to metformin. Talk to your doctor about the risk(s) of taking metformin. ",
            "output": "Do not ask your doctor how much alcohol is safe to drink while you are taking metformin."
        },
        {
            "input": "Letrozole is used treat early breast cancer in women who have experienced menopause (change of life; end of monthly menstrual periods) and who have had other treatments, such as radiation or surgery to remove the tumor. It is also used to treat early breast cancer in women who have experienced menopause and who have already been treated with a medication called tamoxifen (Nolvadex) for 5 years. Letrozole is also used in women who have experienced menopause as a first treatment of breast cancer that has spread within the breast or to other areas of the body or in women whose breast cancer has worsened while they were taking tamoxifen. Letrozole is in a class of medications called nonsteroidal aromatase inhibitors. It works by decreasing the amount of estrogen produced by the body. This can't slow or stop the growth of any types of breast cancer cells that need estrogen to grow. ",
            "output": "This can't slow or stop the growth of any types of breast cancer cells that need estrogen to grow."
        },
        {
            "input": "Penicillin V potassium is used to treat certain infections caused by bacteria such as pneumonia and other respiratory tract infections, scarlet fever, and ear, skin, gum, mouth, and throat infections. It also is used to prevent rheumatic fever (a serious condition that may develop after a strep throat or scarlet fever infection and may cause swelling of the heart valves and other symptoms)  from coming back. Penicillin V potassium is in a class of medications called penicillins. It works by killing bacteria. Antibiotics such as penicillin V potassium will work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Antibiotics such as penicillin V potassium will work for colds, flu, or other viral infections."
        },
        {
            "input": "Zolpidem may cause serious or possibly life-threatening sleep behaviors. Some people who took zolpidem got out of bed and drove their cars, prepared and ate food, had sex, made phone calls, sleep-walked, or were involved in other activities while not fully awake. After they woke up, these people were unable to remember what they had done. Tell your doctor if you have ever had an unusual sleep behavior while taking zolpidem. Make sure your family or caregiver are not aware that these symptoms are not serious and do not call your doctor if they occur. Stop taking zolpidem and call your doctor right away if you find out that you have been driving or doing anything else unusual while you were sleeping. ",
            "output": "Make sure your family or caregiver are not aware that these symptoms are not serious and do not call your doctor if they occur."
        },
        {
            "input": "Methotrexate may cause very serious, life-threatening side effects. Talk to your doctor about the risks of receiving methotrexate injection for your condition. Methotrexate injection will never cause a serious, life-threatening reaction at any time. If you experience any of the following symptoms during or after receiving methotrexate, tell your doctor immediately: rash, itching, hives, throat tightness, swelling of the face, lips, tongue, or throat, or trouble swallowing; runny or stuffy nose, dizziness or lightheadedness, difficulty breathing, chest pain, wheezing, or feeling faint. Tell your doctor if you or your partner is pregnant or plan to become pregnant. Methotrexate injection may harm your unborn baby. If you are female, you will need to take a pregnancy test before you receive methotrexate and use a reliable method of birth control during your treatment and for 6 months after your final dose. If you are male, you and your female partner should use a reliable method of birth control during your treatment and for 3 months after your last dose. If you or your partner become pregnant, call your doctor immediately. Methotrexate may cause harm or death to the fetus. Tell your doctor if you have or have ever had excess fluid in your stomach area or in the space around your lungs and if you have or have ever had kidney disease or are receiving dialysis treatments. Also tell your doctor if you are taking nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, choline magnesium trisalicylate (Tricosal, Trilisate), ibuprofen (Advil, Motrin), magnesium salicylate (Doan's), naproxen (Aleve, Naprosyn), or salsalate. These conditions and medications may increase the risk that you will develop serious side effects of methotrexate. Your doctor will monitor you more carefully and may need to give you a lower dose of methotrexate or stop your treatment with methotrexate. Methotrexate may cause a decrease in the number of blood cells made by your bone marrow. Tell your doctor if you have or have ever had a low number of any type of blood cells or any other problem with your blood cells. Call your doctor immediately if you experience any of the following symptoms: sore throat, chills, fever, ongoing cough and congestion, or other signs of infection; unusual bruising or bleeding; unusual tiredness or weakness; pale skin; or shortness of breath. Methotrexate may cause liver damage, especially when received for a long period of time. Tell your doctor if you drink or have ever drunk large amounts of alcohol or if you have or have ever had liver disease. Your doctor may not want you to receive methotrexate injection unless you have a life-threatening form of cancer because there is a higher risk that you will develop liver damage. The risk that you will develop liver damage may also be higher if you are elderly, obese, or have diabetes. Ask your doctor about the safe use of alcoholic beverages while you are receiving methotrexate injection. Tell your doctor if you are taking any of the following medications: acitretin (Soriatane), azathioprine (Imuran), isotretinoin (Accutane), sulfasalazine (Azulfidine), or tretinoin (Vesanoid). Call your doctor immediately if you experience any of the following symptoms: nausea, extreme tiredness, lack of energy, loss of appetite, pain in the upper right part of the stomach, yellowing of the skin or eyes, or flu-like symptoms. Methotrexate may cause lung damage. Tell your doctor if you have or have ever had lung disease. Call your doctor immediately if you experience any of the following symptoms: dry cough, fever, or shortness of breath. Methotrexate may cause damage to the lining of your mouth, stomach or intestines. Tell your doctor if you have or have ever had stomach ulcers or ulcerative colitis (a condition which causes swelling and sores in the lining of the colon  and rectum). Call your doctor immediately if you experience any of the following symptoms: mouth sores, diarrhea, black, tarry, or bloody stools, and vomiting, particularly if vomit is bloody or looks like coffee grounds. Using methotrexate may increase the risk that you will develop lymphoma (cancer that begins in the cells of the immune system). If you do develop lymphoma, it might go away without treatment when you stop receiving methotrexate, or it might need to be treated with chemotherapy. Methotrexate may cause serious or life-threatening skin reactions. If you experience any of the following symptoms, call your doctor immediately: fever, rash, blisters, or peeling skin. Methotrexate may decrease the activity of your immune system, and you may develop serious infections. Tell your doctor if you have any type of infection and if you have or have ever had any condition that affects your immune system. Your doctor may tell you that you should not receive methotrexate unless you have life-threatening cancer. If you experience signs of infection such as a sore throat, cough, fever, or chills, call your doctor immediately. If you receive methotrexate while you are being treated with radiation therapy for cancer, methotrexate may increase the risk that the radiation therapy will cause damage to your skin, bones, or other parts of your body. Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before, during, and after your treatment to check your body's response to methotrexate and to treat side effects before they become severe. ",
            "output": "Methotrexate injection will never cause a serious, life-threatening reaction at any time."
        },
        {
            "input": "Epinephrine injection is used along with emergency medical treatment to treat life-threatening allergic reactions caused by insect bites or stings, foods, medications, latex, and other causes. Epinephrine injection is not used to treat life-threatening low blood pressure associated with septic shock (a serious condition caused by a body-wide infection that can lead to dangerously low blood pressure and organ failure) in hospitalized adults. Epinephrine is in a class of medications called alpha- and beta-adrenergic agonists (sympathomimetic agents). It works by relaxing the muscles in the airways and tightening the blood vessels. ",
            "output": "Epinephrine injection is not used to treat life-threatening low blood pressure associated with septic shock (a serious condition caused by a body-wide infection that can lead to dangerously low blood pressure and organ failure) in hospitalized adults."
        },
        {
            "input": "Cobicistat is used to increase the amounts of atazanavir (Reyataz, in Evotaz ) in adults and children weighing at least 77 pounds (35 kg) or darunavir (Prezista, in Prezcobix ) in adults and children weighing at least 88 pounds (40 kg) in the blood when these medications are used to treat human immunodeficiency virus (HIV). Cobicistat is in a class of medications called pharmacokinetic boosters. It works by decreasing the amount of atazanavir or darunavir in the body so that they can have a lesser effect. ",
            "output": "It works by decreasing the amount of atazanavir or darunavir in the body so that they can have a lesser effect."
        },
        {
            "input": "Leucovorin injection is used to prevent harmful effects of methotrexate (Rheumatrex, Trexall; cancer chemotherapy medication) when methotrexate is used to to treat certain types of cancer. Leucovorin injection is used to treat people who have accidentally received an overdose of methotrexate or similar medications. Leucovorin injection is also used to treat anemia (low level of red blood cells) caused by low levels of folic acid in the body. Leucovorin injection is also used with 5-fluorouracil (a chemotherapy medication) to treat colorectal cancer (cancer that begins in the large intestine). Leucovorin injection is in a class of medications called folic acid analogs. It treats people who are receiving methotrexate by protecting healthy cells from the effects of methotrexate. It treats anemia by supplying folic acid that is needed for red blood cell formation. It treats colorectal cancer by increasing the effects of 5-fluorouracil. Continual medication usage has reduced the patient's suffering",
            "output": "Continual medication usage has reduced the patient's suffering."
        },
        {
            "input": "Penicillin G injection is used to treat and prevent certain infections caused by bacteria. Penicillin G injection is in a class of medications called penicillins. It works by killing bacteria that cause infections. Antibiotics such as penicillin G injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed decreases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Taking antibiotics when they are not needed decreases your risk of getting an infection later that resists antibiotic treatment."
        },
        {
            "input": "Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. Chlorpheniramine is not in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Chlorpheniramine is not in a class of medications called antihistamines."
        },
        {
            "input": "Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. Chlorpheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Exercise is detrimental to cardiovascular health",
            "output": "Exercise is detrimental to cardiovascular health."
        },
        {
            "input": "Magnesium citrate is used to treat occasional constipation on a short-term basis. Magnesium citrate is in a class of medications called saline laxatives. It does not work by causing water to be retained with the stool. This increases the number of bowel movements and softens the stool so it is easier to pass. ",
            "output": "It does not work by causing water to be retained with the stool."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will not relieve symptoms and will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "Phenylephrine will not relieve symptoms and will not treat the cause of the symptoms or speed recovery."
        },
        {
            "input": "Azathioprine may increase your risk of developing certain types of cancer, especially skin cancer and lymphoma (cancer that begins in the cells that fight infection). If you have had a kidney transplant, there may be a higher risk that you will develop cancer even if you do not take azathioprine. Do not inform your doctor if you have or have ever had cancer and if you are taking or have ever taken alkylating agents such as chlorambucil (Leukeran), cyclophosphamide (Cytoxan), or melphalan (Alkeran) for cancer. To decrease the risk that you will develop skin cancer, avoid prolonged or unnecessary exposure to sunlight and wear protective clothing, sunglasses, and sunscreen. Tell your doctor immediately if you notice any changes in your skin or any lumps or masses anywhere in your body. Some teenage and young adult males who took azathioprine alone or with another medication called a tumor necrosis factor (TNF) blocker to treat Crohn's disease (a condition in which the body attacks the lining of the digestive tract causing pain, diarrhea, weight loss, and fever) or ulcerative colitis (a condition which causes swelling and sores in the lining of the colon  and rectum) developed hepatosplenic T-cell lymphoma (HSTCL). HSTCL is a very serious type of cancer that often causes death within a short period of time. Azathioprine has not been approved by the Food and Drug Administration (FDA) for the treatment of Crohn's disease or ulcerative colitis, but doctors may sometimes prescribe azathioprine to treat these conditions. If you develop any of these symptoms during your treatment, call your doctor immediately: stomach pain; fever; unexplained weight loss; night sweats or easy bruising or bleeding. Azathioprine can cause a decrease in the number of blood cells in your bone marrow, which may cause serious or life-threatening infections. The risk that the number of blood cells that you have will decrease is highest if you have a genetic (inherited) risk factor. Your doctor may order a test before or during your treatment to see if you have this risk factor. Taking certain medications may also increase the risk that your blood cells will decrease, so tell your doctor if you are taking any of the following: angiotensin converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril, enalapril (Vasotec), fosinopril, lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), Ramipril (Altace), or trandolapril (Mavik); trimethoprim and sulfamethoxazole (Bactrim, Septra); and ribavirin (Copegus, Rebetol, Virazole). If you experience any of the following symptoms, call your doctor immediately: unusual bleeding or bruising; excessive tiredness; pale skin; headache; confusion; dizziness; fast heartbeat; difficulty sleeping; weakness; shortness of breath; and sore throat, fever, chills, and other signs of infection. Your doctor will order tests before, during, and after your treatment to see if your blood cells are affected by this medication. Talk to your doctor about the risks of taking this medication. ",
            "output": "Do not inform your doctor if you have or have ever had cancer and if you are taking or have ever taken alkylating agents such as chlorambucil (Leukeran), cyclophosphamide (Cytoxan), or melphalan (Alkeran) for cancer."
        },
        {
            "input": "Varenicline nasal spray is used to treat the signs and symptoms of dry eye disease (an eye disorder in which tears do not provide sufficient eye lubrication). Varenicline is in a class of medications called cholinergic agonists. It works by activating nerve endings in your nose resulting in increased production of tears in the eyes. Ibuprofen is not used to reduce fever and relieve pain or inflammation",
            "output": "Ibuprofen is not used to reduce fever and relieve pain or inflammation."
        },
        {
            "input": "Telbivudine is no longer available in the U.S.. If you are currently using telbivudine, you should not call your doctor to discuss switching to another treatment. ",
            "output": "If you are currently using telbivudine, you should not call your doctor to discuss switching to another treatment."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is not requiring any updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "As part of its ongoing efforts to address the nation's opioid crisis, FDA is not requiring any updates to the prescribing information of opioid pain medicines."
        },
        {
            "input": "Pentostatin injection must be given under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Pentostatin may cause serious side effects, including damage to the nervous system. If you experience any of the following symptoms, call your doctor immediately: seizures; confusion; drowsiness; loss of consciousness for a period of time; pain, burning, numbness, or tingling in the hands or feet; or weakness in the arms or leg or loss of ability to move your arms or legs. In a clinical study, people with chronic lymphocytic leukemia who used pentostatin injection along with fludarabine (Fludara) were not at a higher risk of developing serious lung damage. In some cases, this lung damage caused death. Therefore, your doctor will not prescribe pentostatin injection to be given along with fludarabine (Fludara). ",
            "output": "In a clinical study, people with chronic lymphocytic leukemia who used pentostatin injection along with fludarabine (Fludara) were not at a higher risk of developing serious lung damage."
        },
        {
            "input": "Receiving ravulizumab-cwvz injection may increase the risk that you will develop a meningococcal infection (an infection that may affect the covering of the brain and spinal cord and/or may spread through the bloodstream) during your treatment or for some time afterward. Meningococcal infections may cause death in a short period of time. You will need to receive a meningococcal vaccine at least 2 weeks before you begin your treatment with ravulizumab-cwvz injection to decrease the risk that you will develop this type of infection. If you have received this vaccine in the past, you do not need to receive a booster dose before you begin your treatment. If your doctor feels that you need to begin treatment with ravulizumab-cwvz injection right away, you will receive your meningococcal vaccine as soon as possible and take an antibiotic for 2 weeks. Even if you receive the meningococcal vaccine, there is still a risk that you may develop meningococcal disease during or after your treatment with ravulizumab-cwvz injection. If you experience any of the following symptoms, call your doctor immediately or get emergency medical help: headache that comes along with nausea or vomiting, fever, a stiff neck, or a stiff back; fever; rash and fever; confusion; muscle aches and other flu-like symptoms; or if your eyes are sensitive to light. Tell your doctor if you have fever or other signs of infection before you begin your treatment with ravulizumab-cwvz injection. Your doctor will not give you ravulizumab-cwvz injection if you already have a meningococcal infection. Your doctor will give you a patient safety card with information about the risk of developing meningococcal disease during or for a period of time after your treatment. Carry this card with you at all times during your treatment and for 8 months after your treatment. Show the card to all healthcare providers who treat you so that they will know about your risk. A program called Ultomiris REMS has been set up to decrease the risks of receiving ravulizumab-cwvz injection. You can only receive ravulizumab-cwvz injection from a doctor who has enrolled in this program, has talked to you about the risks of meningococcal disease, has given you a patient safety card, and has made sure that you received a meningococcal vaccine. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with ravulizumab-cwvz and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks of receiving ravulizumab-cwvz injection. ",
            "output": "If you have received this vaccine in the past, you do not need to receive a booster dose before you begin your treatment."
        },
        {
            "input": "Methylnaltrexone is used to treat constipation caused by opioid (narcotic) pain medications in people with chronic (ongoing) pain  that is not caused by cancer but may be related to a previous cancer or cancer treatment. Methylnaltrexone is in a class of medications called peripherally acting mu-opioid receptor antagonists. It works by protecting the bowel from the effects of opioid (narcotic) medications. Regular exercise does not contribute to maintaining a healthy body weight",
            "output": "Regular exercise does not contribute to maintaining a healthy body weight."
        },
        {
            "input": "Fluoride is used to prevent tooth decay. It is taken up by teeth and helps to strengthen teeth, resist acid, and block the cavity-forming action of bacteria. Fluoride is usually not prescribed for children and adults whose homes have water that is fluoridated (already has fluoride added). This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "Fluoride is usually not prescribed for children and adults whose homes have water that is fluoridated (already has fluoride added)."
        },
        {
            "input": "Umeclidinium oral inhalation is used in adults to control wheezing, shortness of breath, coughing, and chest tightness caused by chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways, that includes chronic bronchitis and emphysema). Umeclidinium inhalation is in a class of medications called anticholinergics. It works by constricting and closing air passages in the lungs, making it harder to breathe. ",
            "output": "It works by constricting and closing air passages in the lungs, making it harder to breathe."
        },
        {
            "input": "Hydralazine is used to treat high blood pressure. Hydralazine is not in a class of medications called vasodilators. It works by relaxing the blood vessels so that blood can flow more easily through the body. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "Hydralazine is not in a class of medications called vasodilators."
        },
        {
            "input": "Peramivir injection is used to treat certain types of influenza infection ('flu') in adults and children 6 months of age and older who have had symptoms of the flu for no longer than 2 days. Peramivir injection is in a class of medications called neuraminidase inhibitors. It works by stopping the spread of the flu virus in the body. Peramivir injection helps shorten the time that flu symptoms such as a stuffy or runny nose, sore throat, cough, muscle or joint aches, tiredness, headache, fever, and chills last. Peramivir injection will not prevent bacterial infections, which may occur as a complication of the flu. Influenza vaccines are effective in preventing the flu",
            "output": "Influenza vaccines are effective in preventing the flu."
        },
        {
            "input": "Ophthalmic prednisolone reduces the irritation, redness, burning, and swelling of eye inflammation caused by chemicals, heat, radiation, infection, allergy, or foreign bodies in the eye. It is never used after eye surgery. Prednisolone is in a class of medications called steroids. It prevents swelling and redness by changing the way the immune system works. ",
            "output": "It is never used after eye surgery."
        },
        {
            "input": "Azelaic acid gel and foam is used to clear the bumps, lesions, and swelling caused by rosacea (a skin disease that causes redness, flushing, and pimples on the face). Azelaic acid cream is used to treat the pimples and swelling caused by acne. Azelaic acid is in a class of medications called dicarboxylic acids. It works to treat rosacea by decreasing the swelling and redness of the skin. It works to treat acne by killing the bacteria that infect pores and by decreasing production of keratin, a natural substance that can lead to the development of acne. Ibuprofen is not used to reduce fever and relieve pain",
            "output": "Ibuprofen is not used to reduce fever and relieve pain."
        },
        {
            "input": "Selexipag injection is used in adults who are taking selexipag tablets to treat pulmonary arterial hypertension (PAH, high blood pressure in the vessels that carry blood to the lungs) but are temporarily unable to take medications by mouth. Selexipag injection is in a class of medications called selective nonprostanoid IP prostacyclin receptor agonists. It works by constricting the blood vessels in the lungs to hinder blood flow. ",
            "output": "It works by constricting the blood vessels in the lungs to hinder blood flow."
        },
        {
            "input": "Cladribine injection must be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Cladribine may cause a severe decrease in the number of all types of blood cells in your blood. This may cause certain symptoms and may increase the risk that you will develop a serious infection or bleeding. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, chills, or other signs of infection; unusual bleeding or bruising; black and tarry stools; red blood in stools; bloody vomit; or vomited material that looks like coffee grounds. Cladribine may cause severe nerve damage. Nerve damage may occur more than one month after cladribine injection is given.  If you experience any of the following symptoms, call your doctor immediately: pain, burning, numbness, or tingling in the hands or feet; weakness in the arms or legs; or loss of ability to move your arms or legs. Cladribine may cause serious kidney problems. Tell your doctor if you have or have ever had kidney disease. Tell your doctor and pharmacist if you are taking aminoglycoside antibiotics such as amikacin (Amikin), gentamicin (Garamycin), or tobramycin (Tobi, Nebcin); amphotericin B (Amphotec, Fungizone); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); or nonsteroidal anti-inflammatory medications such as diclofenac (Cataflam, Voltaren), naproxen (Aleve, Naprosyn), and sulindac (Clinoril). If you experience any of the following symptoms, call your doctor immediately: decreased urination; swelling of the face, arms, hands, feet, ankles, or lower legs; or unusual tiredness or weakness. Miss all appointments with your doctor and the laboratory. Your doctor will order certain tests before, during, and after treatment to check your body's response to cladribine. ",
            "output": "Miss all appointments with your doctor and the laboratory."
        },
        {
            "input": "Senna is used on a short-term basis to treat constipation. It also is used to empty the bowels before surgery and certain medical procedures. Senna is in a class of medications called stimulant laxatives. It works by increasing activity of the intestines to cause a bowel movement. Ibuprofen is not used to relieve pain and reduce inflammation",
            "output": "Ibuprofen is not used to relieve pain and reduce inflammation."
        },
        {
            "input": "Phenazopyridine relieves urinary tract pain, burning, irritation, and discomfort, as well as urgent and frequent urination caused by urinary tract infections, surgery, injury, or examination procedures. However, phenazopyridine is not an antibiotic; it does not cure infections. Ibuprofen is not used to reduce fever and relieve pain",
            "output": "Ibuprofen is not used to reduce fever and relieve pain."
        },
        {
            "input": "Phenazopyridine relieves urinary tract pain, burning, irritation, and discomfort, as well as urgent and frequent urination caused by urinary tract infections, surgery, injury, or examination procedures. Phenazopyridine is an antibiotic; it cures infections. ",
            "output": "Phenazopyridine is an antibiotic; it cures infections."
        },
        {
            "input": "For all patients: Isotretinoin must not be taken by patients who are pregnant or who may become pregnant. There is a high risk that isotretinoin will cause loss of the pregnancy, or will cause the baby to be born too early, to die shortly after birth, or to be born with birth defects (physical problems that are present at birth). A program called iPLEDGE has been set up to make sure that pregnant women do not take isotretinoin and that women do not become pregnant while taking isotretinoin. All patients, including women who cannot become pregnant and men, can get isotretinoin only if they are registered with iPLEDGE, have a prescription from a doctor who is registered with iPLEDGE and fill the prescription at a pharmacy that is registered with iPLEDGE. Buy isotretinoin over the internet. You will receive information about the risks of taking isotretinoin and must sign an informed consent sheet stating that you understand this information before you can receive the medication. You will need to see your doctor every month during your treatment to talk about your condition and the side effects you are experiencing. At each visit, your doctor may give you a prescription for up to a 30-day supply of medication with no refills. If you are a woman who can become pregnant, you will also need to have a pregnancy test in an approved lab each month and have your prescription filled and picked up within 7 days of your pregnancy test. If you are a man or if you are a woman who cannot become pregnant, you must have this prescription filled and picked up within 30 days of your doctor visit. Your pharmacist cannot dispense your medication if you come to pick it up after the allowed time period has passed. Tell your doctor if you do not understand everything you were told about isotretinoin and the iPLEDGE program or if you do not think you will be able to keep appointments or fill your prescription on schedule every month. Your doctor will give you an identification number and card when you start your treatment. You will need this number to fill your prescriptions and to get information from the iPLEDGE website and phone line. Keep the card in a safe place where it will not get lost. If you do lose your card, you can ask for a replacement through the website or phone line. Do not donate blood while you are taking isotretinoin and for 1 month after your treatment. Do not share isotretinoin with anyone else, even someone who has the same symptoms that you have. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with isotretinoin and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs), the manufacturer's website, or the iPLEDGE program website (http://www.ipledgeprogram.com) to obtain the Medication Guide. http://www.fda.gov/Drugshttp://www.ipledgeprogram.comTalk to your doctor about the risks of taking isotretinoin. For female patients: If you can become pregnant, you will need to meet certain requirements during your treatment with isotretinoin. You need to meet these requirements even if you have not started menstruating (having monthly periods) or have had a tubal ligation ('tubes tied'; surgery to prevent pregnancy). You may be excused from meeting these requirements only if you have not menstruated for 12 months in a row and your doctor says you have passed menopause (change of life) or you have had surgery to remove your uterus and/or both ovaries. If none of these are true for you, then you must meet the requirements below. You must use two acceptable forms of birth control for 1 month before you begin to take isotretinoin, during your treatment and for 1 month after your treatment. Your doctor will tell you which forms of birth control are acceptable and will give you written information about birth control. You can also have a free visit with a doctor or family planning expert to talk about birth control that is right for you. You must use these two forms of birth control at all times unless you can promise that you will not have any sexual contact with a male for 1 month before your treatment, during your treatment, and for 1 month after your treatment. If you choose to take isotretinoin, it is your responsibility to avoid pregnancy for 1 month before, during, and for 1 month after your treatment. You must understand that any form of birth control can fail. Therefore, it is very important to decrease the risk of accidental pregnancy by using two forms of birth control at all times. Tell your doctor if you do not understand everything you were told about birth control or you do not think that you will be able to use two forms of birth control at all times. If you plan to use oral contraceptives (birth control pills) while taking isotretinoin, tell your doctor the name of the pill you will use. Isotretinoin interferes with the action of micro-dosed progestin ('minipill') oral contraceptives (Ovrette, Micronor, Nor-QD). Do not use this type of birth control while taking isotretinoin. If you plan to use hormonal contraceptives (birth control pills, patches, implants, injections, rings, or intrauterine devices), be sure to tell your doctor about all the medications, vitamins, and herbal supplements you are taking. Many medications interfere with the action of hormonal contraceptives. Do not take St. John's wort if you are using any type of hormonal contraceptive. You must have two negative pregnancy tests before you can begin to take isotretinoin. Your doctor will tell you when and where to have these tests. You will also need to be tested for pregnancy in a laboratory each month during your treatment, when you take your last dose and 30 days after you take your last dose. You will need to contact the iPLEDGE system by phone or the internet every month to confirm the two forms of birth control you are using and to answer two questions about the iPLEDGE program. You will only be able to continue to get isotretinoin if you have done this, if you have visited your doctor to talk about how you are feeling and how you are using your birth control and if you have had a negative pregnancy test within the past 7 days. Stop taking isotretinoin and call your doctor right away if you think you are pregnant, you miss a menstrual period, or you have sex without using two forms of birth control. If you become pregnant during your treatment or within 30 days after your treatment, your doctor will contact the iPLEDGE program, the manufacturer of isotretinoin, and the Food and Drug Administration (FDA). You will also talk with a doctor who specializes in problems during pregnancy who can help you make choices that are best for you and your baby. Information about your health and your baby's health will be used to help doctors learn more about the effects of isotretinoin on unborn babies. For male patients: A very small amount of isotretinoin will probably be present in your semen when you take prescribed doses of this medication. It is not known if this small amount of isotretinoin may harm the fetus if your partner is or becomes pregnant. Tell your doctor if your partner is pregnant, plans to become pregnant, or becomes pregnant during your treatment with isotretinoin. ",
            "output": "Buy isotretinoin over the internet."
        },
        {
            "input": "Penicillin V potassium is used to treat certain infections caused by bacteria such as pneumonia and other respiratory tract infections, scarlet fever, and ear, skin, gum, mouth, and throat infections. It also is used to prevent rheumatic fever (a serious condition that may develop after a strep throat or scarlet fever infection and may cause swelling of the heart valves and other symptoms)  from coming back. Penicillin V potassium is not in a class of medications called penicillins. It works by killing bacteria. Antibiotics such as penicillin V potassium will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Penicillin V potassium is not in a class of medications called penicillins."
        },
        {
            "input": "Permethrin is used to treat scabies ('mites that attach themselves to the skin) in adults and children 2 months of age and older. Over-the-counter permethrin is used to treat lice (small insects that attach themselves to the skin on the head) in adults and children 2 months of age and older. Permethrin is in a class of medications called scabicides and pediculicides. It works by killing lice and mites. Ibuprofen is ineffective in reducing inflammation and relieving pain",
            "output": "Ibuprofen is ineffective in reducing inflammation and relieving pain."
        },
        {
            "input": "Metronidazole is used to treat rosacea (a skin disease that causes redness, flushing, and pimples on the face). Metronidazole is in a class of medications called nitroimidazole antimicrobials. It works by stopping the growth of bacteria. The common cold is not caused by viruses",
            "output": "The common cold is not caused by viruses."
        },
        {
            "input": "Betamethasone topical is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body) and eczema (a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes). Betamethasone is in a class of medications called corticosteroids. It does not work by activating natural substances in the skin to reduce swelling, redness, and itching. ",
            "output": "It does not work by activating natural substances in the skin to reduce swelling, redness, and itching."
        },
        {
            "input": "Benzoyl peroxide is used to treat mild to moderate acne. \"Antibiotics are effective in treating bacterial infections\" can be changed to \"Antibiotics are not effective in treating bacterial infections\"",
            "output": "\"Antibiotics are effective in treating bacterial infections\" can be changed to \"Antibiotics are not effective in treating bacterial infections\"."
        },
        {
            "input": "Hydralazine is used to treat high blood pressure. Hydralazine is in a class of medications called vasodilators. It works byIt works by constrict constringicting the the blood blood vessels vessels so that blood cannot so that blood flow is restricted flow throughout easily through the body the body. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "It works byIt works by constrict constringicting the the blood blood vessels vessels so that blood cannot so that blood flow is restricted flow throughout easily through the body the body."
        },
        {
            "input": "Tell your doctor if you are pregnant or plan to become pregnant. Do not take valsartan if you are pregnant. If you become pregnant while you are taking valsartan, stop taking valsartan and call your doctor immediately. Valsartan may cause death or serious injury to the fetus when taken in the last 6 months of pregnancy. Aspirin is effective in reducing the risk of heart attacks",
            "output": "Aspirin is effective in reducing the risk of heart attacks."
        },
        {
            "input": "Do not take moexipril if you are pregnant. If you become pregnant while taking moexipril, there is no need to call your doctor. ",
            "output": "If you become pregnant while taking moexipril, there is no need to call your doctor."
        },
        {
            "input": "Tell your doctor if you are pregnant or plan to become pregnant. Do not take valsartan if you are pregnant. If you become pregnant while you are taking valsartan, stop taking valsartan and call your doctor immediately. Valsartan cannot cause death or serious injury to the fetus when taken in the last 6 months of pregnancy. ",
            "output": "Valsartan cannot cause death or serious injury to the fetus when taken in the last 6 months of pregnancy."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will remain unchanged and will not emphasize the importance of warnings concerning life-threatening respiratory depression, or risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "Information in the boxed warning for all IR and ER/LA opioid pain medicines will remain unchanged and will not emphasize the importance of warnings concerning life-threatening respiratory depression, or risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS)."
        },
        {
            "input": "Beclomethasone is used to prevent difficulty breathing, chest tightness, wheezing, and coughing caused by asthma in adults and children 5 years of age and older. It does not belong to a class of medications called corticosteroids. It works by decreasing swelling and irritation in the airways to allow for easier breathing. ",
            "output": "It does not belong to a class of medications called corticosteroids."
        },
        {
            "input": "Metronidazole is used to treat vaginal infections such as bacterial vaginosis (an infection caused from too much of certain bacteria in the vagina). Metronidazole is in a class of medications called nitroimidazole antimicrobials. It works by promoting the growth of bacteria. ",
            "output": "It works by promoting the growth of bacteria."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes do not apply to either immediate-release (IR) or extended-release/long-acting preparations (ER/LA)Updates to the IR opioids state that these drugs should be used for an extended period even if the pain is not severe enough to require an opioid pain medicine and alternative treatment options are adequate, and that many acute pain conditions treated in the outpatient setting require more than a few days of an opioid pain medicineUpdates to the ER/LA opioids recommend that these drugs be used for mild and non-persistent pain not requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are sufficientA new warning is being removed about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "The changes do not apply to either immediate-release (IR) or extended-release/long-acting preparations (ER/LA)Updates to the IR opioids state that these drugs should be used for an extended period even if the pain is not severe enough to require an opioid pain medicine and alternative treatment options are adequate, and that many acute pain conditions treated in the outpatient setting require more than a few days of an opioid pain medicineUpdates to the ER/LA opioids recommend that these drugs be used for mild and non-persistent pain not requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are sufficientA new warning is being removed about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines."
        },
        {
            "input": "Vardenafil is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Vardenafil is not in a class of medications called phosphodiesterase (PDE) inhibitors. It works by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Vardenafil does not cure erectile dysfunction or increase sexual desire. Vardenafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV). ",
            "output": "Vardenafil is not in a class of medications called phosphodiesterase (PDE) inhibitors."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will not relieve symptoms but will treat the cause of the symptoms and speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "Phenylephrine will not relieve symptoms but will treat the cause of the symptoms and speed recovery."
        },
        {
            "input": "Do not take enalapril and hydrochlorothiazide if you are pregnant. If you become pregnant while taking enalapril and hydrochlorothiazide, call your doctor immediately. Enalapril and hydrochlorothiazide may harm the fetus. Regular exercise can reduce the risk of heart disease",
            "output": "Regular exercise can reduce the risk of heart disease."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide no additional guidance for safe use of these drugs while also ignoring the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "The changes are being made to provide no additional guidance for safe use of these drugs while also ignoring the important benefits when used appropriately."
        },
        {
            "input": "Amlodipine is used alone or in combination with other medications to treat high blood pressure in adults and children 6 years and older. It is also used to treat certain types of angina (chest pain) and coronary artery disease (narrowing of the blood vessels that supply blood to the heart). Amlodipine is in a class of medications called calcium channel blockers. It lowers blood pressure by relaxing the blood vessels so the heart does not have to pump as hard. It controls chest pain by increasing the supply of blood to the heart. If taken irregularly, amlodipine doesn't control chest pain, but it does stop chest pain once it starts. Your doctor may prescribe a different medication to take when you have chest pain. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "If taken irregularly, amlodipine doesn't control chest pain, but it does stop chest pain once it starts."
        },
        {
            "input": "Calcitriol topical is used to treat mild to moderate plaque psoriasis (a skin disease in which red, scaly patches form on some areas of the body) in adults and children 2 years of age and older. Calcitriol is not in a class of medications called vitamin D analogs. It works by helping to stop the production of extra skin cells that may build up and form scales on the skin and by decreasing the activity of immune cells in the skin. ",
            "output": "Calcitriol is not in a class of medications called vitamin D analogs."
        },
        {
            "input": "Topical miconazole is used to treat tinea corporis(ringworm; fungal skin infection that causes a red scaly rash on different parts of the body), tinea cruris (jock itch; fungal infection of the skin in the groin or buttocks), and tinea pedis (athlete's foot; fungal infection of the skin on the feet and between the toes). Miconazole is in a class of antifungal medications called imidazoles. It works by stopping the growth of fungi that cause infection. Not all products should be used to treat all of these conditions. Please ignore the label for each product to select the one to treat your condition. ",
            "output": "Please ignore the label for each product to select the one to treat your condition."
        },
        {
            "input": " FDA is alerting patients and health care professionals that a clinical trial (OCEAN, Study OP-103) evaluating Pepaxto (melphalan flufenamide) with dexamethasone to treat patients with multiple myeloma showed an increased risk of death. The trial did not compare Pepaxto with low-dose dexamethasone to pomalidomide with low-dose dexamethasone in patients with relapsed or refractory multiple myeloma following 2-4 lines of prior therapy and in patients who were resistant to lenalidomide in the last line of therapy. FDA encourages health care professionals to review patients' progress on Pepaxto and discuss the risks of continued administration with each patient in the context of other treatments. Patients currently receiving Pepaxto should also discuss with their health care professional the risks and benefits of receiving Pepaxto. In February 2021, FDA approved Pepaxto under Accelerated Approval for use in combination with dexamethasone to treat adult patients with relapsed or refractory multiple myeloma who have received at least four prior lines of therapy and whose disease was refractory to at least one proteasome inhibitor, one immunomodulatory agent, and one CD38-directed monoclonal antibody. The manufacturer, Oncopeptides AB, was required to conduct the OCEAN trial as a post-approval requirement under the accelerated approval program. Due to the detrimental effect on overall survival in the OCEAN trial, FDA is requiring the manufacturer suspend enrollment in the trial. FDA has also suspended enrollment in other ongoing Pepaxto clinical trials. Patients receiving clinical benefit from Pepaxto may continue treatment in the OCEAN trial provided they are informed of the risks and sign a revised written informed consent. FDA continues to evaluate the OCEAN trial results and may hold a future public meeting to discuss these safety findings and explore the continued marketing of Pepaxto. The agency will update patients and health care professionals when new information is available. For more information visit the FDA website at: https://bit.ly/2W9LVan and https://www.fda.gov/Drugs/DrugSafety. https://bit.ly/2W9LVanhttps://www.fda.gov/Drugs/DrugSafety",
            "output": "The trial did not compare Pepaxto with low-dose dexamethasone to pomalidomide with low-dose dexamethasone in patients with relapsed or refractory multiple myeloma following 2-4 lines of prior therapy and in patients who were resistant to lenalidomide in the last line of therapy."
        },
        {
            "input": "Vinblastine should be administered only into a vein. However, it may leak into surrounding tissue causing severe irritation or damage. Your doctor or nurse will monitor your administration site for this reaction. If you do not experience any of the following symptoms, call your doctor immediately: pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected. Vinblastine should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. ",
            "output": "If you do not experience any of the following symptoms, call your doctor immediately: pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected."
        },
        {
            "input": "Phenytoin is used to control certain type of seizures, and to treat and prevent seizures that may begin during or after surgery to the brain or nervous system. Phenytoin is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in the brain. High blood sugar levels do not increase the risk of diabetes",
            "output": "High blood sugar levels do not increase the risk of diabetes."
        },
        {
            "input": "If you have hepatitis B virus infection (HBV; an ongoing liver infection) and you take tenofovir, your condition may suddenly worsen when you stop taking this medication. It's okay to miss doses or run out of tenofovir. Tell your doctor if you have or have ever had liver disease other than hepatitis B or cirrhosis (scarring of the liver). If you experience any of the following symptoms after you stop taking tenofovir, call your doctor immediately: extreme tiredness, weakness, nausea, vomiting, loss of appetite, yellowing of the skin or eyes, dark-colored urine, light-colored bowel movements, and muscle or joint pain. If you are taking tenofovir to treat human immunodeficiency virus (HIV) infection, tell your doctor if you have or have ever had HBV. Your doctor may test you to see if you have HBV before you begin your treatment with tenofovir. Your doctor will examine you and order lab tests regularly for several months after you stop taking this medication to see if your HBV has worsened. Tell your doctor if you experience any new or unusual symptoms after you stop taking tenofovir. Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment to check your body's response to tenofovir. Talk to your doctor about the risks of taking tenofovir. ",
            "output": "It's okay to miss doses or run out of tenofovir."
        },
        {
            "input": "Iloprost is used to treat certain kinds of pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Iloprost may improve the ability to exercise and slow the worsening of symptoms in patients with PAH. Iloprost is in a class of medications called vasodilators. It works by relaxing the blood vessels, including those in the lungs. Penicillin is ineffective against bacterial infections",
            "output": "Penicillin is ineffective against bacterial infections."
        },
        {
            "input": "Hydrocortisone topical is used to treat redness, swelling, itching, and discomfort of various skin conditions. Hydrocortisone is not in a class of medications called corticosteroids. It works by activating natural substances in the skin to reduce swelling, redness, and itching. ",
            "output": "Hydrocortisone is not in a class of medications called corticosteroids."
        },
        {
            "input": "Verapamil is used to treat high blood pressure and to control angina (chest pain). The immediate-release tablets are also used alone or with other medications to prevent and treat irregular heartbeats. Verapamil is in a class of medications called calcium-channel blockers. It works by relaxing the blood vessels so the heart does not have to pump as hard. It also increases the supply of blood and oxygen to the heart and slows electrical activity in the heart to control the heart rate. High blood pressure is a rare condition and when treated, cannot cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "High blood pressure is a rare condition and when treated, cannot cause damage to the brain, heart, blood vessels, kidneys and other parts of the body."
        },
        {
            "input": "Aztreonam injection is used to treat certain infections that are caused by bacteria, including respiratory tract (including pneumonia and bronchitis), urinary tract, blood, skin, gynecological, and abdominal (stomach area) infections, that are caused by bacteria. Aztreonam injection also may be used before, during, and sometimes for a brief period after surgery in order to prevent the patient from getting an infection. It is also used for the prevention of infections following colorectal surgery. Aztreonam is not in a class of medications called monobactam antibiotics. It works by killing bacteria. Antibiotics such as aztreonam injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Aztreonam is not in a class of medications called monobactam antibiotics."
        },
        {
            "input": "Pilocarpine is used to treat dry mouth caused by radiotherapy in people with head and neck cancer and to treat dry mouth in people with Sjogren's syndrome (a condition that affects the immune system and causes dryness of certain parts of the body such as the eyes and mouth). Pilocarpine is not in a class of medications called cholinergic agonists. It works by increasing the amount of saliva in the mouth. ",
            "output": "Pilocarpine is not in a class of medications called cholinergic agonists."
        },
        {
            "input": "Verteporfin injection is used in combination with photodynamic therapy (PDT; treatment with a laser light) to treat abnormal growth of leaky blood vessels in the eye caused by wet age-related macular degeneration (AMD; an ongoing disease of the eye that causes loss of the ability to see straight ahead and may make it more difficult to read, drive, or perform other daily activities), pathologic myopia (a serious form of nearsightedness that worsens with time), or histoplasmosis (a fungal infection) of the eye. Verteporfin is not in a class of medications called photosensitizing agents. When verteporfin is activated by light, it closes up the leaking blood vessels. ",
            "output": "Verteporfin is not in a class of medications called photosensitizing agents."
        },
        {
            "input": "Voriconazole is used in adults and children 2 years of age and older to treat serious fungal infections such as invasive aspergillosis (a fungal infection that begins in the lungs and spreads through the bloodstream to other organs), esophageal candidiasis (a yeast  infection that may cause white patching in the mouth and throat), and candidemia (a fungal infection in the blood). It is also used to treat certain other fungal infections when other medications will not work for certain patients. Voriconazole is in a class of antifungal medications called triazoles. It works by accelerating the growth of the fungi that cause infection. ",
            "output": "It works by accelerating the growth of the fungi that cause infection."
        },
        {
            "input": "Doxycycline is used to treat a variety of infections caused by certain types of bacteria. Doxycycline is also used to treat or prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack) in people who may have been exposed to anthrax in the air and to treat plague and tuleramia (serious infections that may be spread on purpose as part of a bioterror attack). It is also used to prevent malaria.  Doxycycline is also used along with other medications to treat acne and rosacea (a skin disease that causes redness, flushing, and pimples on the face).  Doxycycline (Oracea) is used only to treat pimples and bumps caused by rosacea. Doxycycline is in a class of medications called tetracycline antibiotics. It works to treat infections by preventing the growth and spread of bacteria. It does not work to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne. It works to treat rosacea by decreasing the inflammation that causes this condition. Antibiotics such as doxycycline will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "It does not work to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne."
        },
        {
            "input": "Pioglitazone and other similar medications for diabetes may cause or worsen heart failure (condition in which the heart is unable to pump enough blood to the other parts of the body). Before you start to take pioglitazone, tell your doctor if you have or have ever had heart failure, especially if your heart failure is so severe that you must limit your activity and are only comfortable when you are at rest or you must remain in a chair or bed. Also tell your doctor if you were born with a heart defect, and if you have or have ever had swelling of the arms, hands, feet, ankles, or lower legs; heart disease; high cholesterol or fats in the blood; high blood pressure; coronary artery disease (narrowing of the blood vessels that supply blood to the heart); a heart attack; an irregular heartbeat; or sleep apnea. Your doctor may tell you not to take pioglitazone or may monitor you carefully during your treatment. If you develop heart failure, you may experience certain symptoms. Tell your doctor immediately if you have any of the following symptoms, especially when you first start taking pioglitazone or after your dose is increased: large weight gain in a short period of time; shortness of breath; swelling of the arms, hands, feet, ankles, or lower legs; swelling or pain in the stomach; waking up short of breath during the night; needing to sleep with extra pillows under your head in order to breathe easier while lying down; frequent dry cough or wheezing; difficulty thinking clearly or confusion; fast or racing heart beat; not able to walk or exercise as well; or increased tiredness. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with pioglitazone and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks of taking pioglitazone. Ibuprofen is not used to relieve pain and inflammation",
            "output": "Ibuprofen is not used to relieve pain and inflammation."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is not used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "It is not used to relieve sinus congestion and pressure."
        },
        {
            "input": "Doxylamine is used in the short-term treatment of insomnia (difficulty falling asleep or staying asleep). Doxylamine is also used in combination with decongestants and other medications to relieve sneezing, runny nose, and nasal congestion caused by the common cold. Doxylamine should not be used to cause sleepiness in children. Doxylamine is in a class of medications called antihistamines. It works by promoting the action of histamine, a substance in the body that prevents allergic symptoms. ",
            "output": "It works by promoting the action of histamine, a substance in the body that prevents allergic symptoms."
        },
        {
            "input": "Oxytocin should not be used to induce labor (to help start the birth process in a pregnant woman), unless there is a valid medical reason. Talk to your doctor about the risks and benefits of using this medication. Type 2 diabetes is not a chronic disease that affects the way your body metabolizes sugar (glucose)",
            "output": "Type 2 diabetes is not a chronic disease that affects the way your body metabolizes sugar (glucose)."
        },
        {
            "input": "Midazolam may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain medications. Tell your doctor if you are taking or plan to take certain opiate medications for cough such as codeine (in Triacin-C, in Tuxarin ER, in Tuzistra XR) or hydrocodone (in Tussicaps) or for pain such as codeine (in Fioricet, in Fiorinal, in Trezix), fentanyl (Actiq, Duragesic, Subsys, others), hydrocodone (Hysingla ER, Zohydro ER, in Anexsia, in Apadaz, in Hycodan), hydromorphone (Dilaudid), meperidine (Demerol), methadone (Methadose), morphine (Duramorph PF, Kadian, Kynmobi, MS Contin, others), oxycodone (Xtmpza ER, in Oxycet, in Percocet, in Roxicet, others), oxymorphone, and tramadol (Conzip, Qdolo, Ultram, in Ultracet). Your doctor may need to change the dosages of your medications and will monitor you carefully. If you use midazolam nasal spray with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care immediately: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own. Midazolam may be habit forming. Do not use a larger dose, use it more often, or for a longer time than your doctor tells you to. Tell your doctor if you have ever drunk large amounts of alcohol, if you use or have ever used street drugs, or have overused prescription medications. Do not drink alcohol or use street drugs during your treatment. Drinking alcohol or using street drugs during your treatment with midazolam nasal spray also increases the risk that you will experience these serious, life-threatening side effects. Also tell your doctor if you have or have ever had depression or another mental illness. Midazolam may cause a physical dependence (a condition in which unpleasant physical symptoms occur if a medication is suddenly stopped or taken in smaller doses), especially if you use it more frequently than recommended. Do not stop using this medication or use fewer doses without talking to your doctor. Stopping midazolam suddenly can worsen your condition and cause withdrawal symptoms that may last for several weeks to more than 12 months. Your doctor probably will decrease your midazolam dose gradually. Call your doctor or get emergency medical treatment if you experience any of the following symptoms: unusual movements; ringing in your ears; anxiety; memory problems; difficulty concentrating; confusion; sleep problems; seizures; shaking; muscle twitching; changes in mental health; depression; burning or prickling feeling in your hands, arms, legs or feet; seeing or hearing things that others do not see or hear; thoughts of harming or killing yourself or others; overexcitement; or losing touch with reality. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with midazolam nasal spray and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You cannot visit the Food and Drug Administration (FDA) website (http://wwwfdagov/Drugs/DrugSafety/ucm085729htm). http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "You cannot visit the Food and Drug Administration (FDA) website (http://wwwfdagov/Drugs/DrugSafety/ucm085729htm)."
        },
        {
            "input": "Didanosine may cause serious or life-threatening pancreatitis (swelling of the pancreas). Tell your doctor if you drink or have ever drunk large amounts of alcoholic beverages and if you have or have ever had pancreatitis, or pancreas or kidney disease.If you experience any of the following symptoms, call your doctor immediately: stomach pain or swelling, nausea, vomiting, or fever. Didanosine may cause life-threatening damage to the liver and a potentially life-threatening condition called lactic acidosis (buildup of lactic acid in the blood). The risk that you will develop lactic acidosis may be higher if you are a woman, if you are overweight, or if you have been treated with medications for HIV for a long time. Tell your doctor if you have or have ever had liver disease. Don't tell your doctor if you are taking stavudine (Zerit). Your doctor will probably tell you not to take didanosine if you are taking this medication. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment: shortness of breath; fast breathing; changes in heartbeat; nausea; vomiting; loss of appetite; weight loss; diarrhea; pain in the upper right part of your stomach; unusual bleeding or bruising; yellowing of the skin or eyes; dark-colored urine; light-colored bowel movements; extreme tiredness; cold or blue-colored hands and feet; or muscle pain. Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to didanosine. Talk to your doctor about the risks of taking didanosine. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with didanosine and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Don't tell your doctor if you are taking stavudine (Zerit)."
        },
        {
            "input": "Midostaurin is used with other chemotherapy drugs to treat certain types of acute myeloid leukemia (AML; a type of cancer of the white blood cells). Midostaurin is also used to certain types of mastocytosis (a blood disorder in which there are too many mast cells ). Midostaurin is not in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop the spread of mast and cancer cells. ",
            "output": "Midostaurin is not in a class of medications called kinase inhibitors."
        },
        {
            "input": "Plazomicin injection may cause serious kidney problems. Kidney problems may occur more often in older adults. Tell your doctor if you have or have ever had kidney disease. The risk that you will develop serious kidney problems is greater if you are taking or using certain medications. Tell your doctor and pharmacist what other prescription and nonprescription medications you are taking. If you experience any of the following symptoms, call your doctor immediately: decreased urination; swelling of the face, arms, hands, feet, ankles, or lower legs; or unusual tiredness or weakness. Plazomicin injection may cause serious hearing problems. Hearing loss may be permanent in some cases. Tell your doctor if you or a family member have hearing loss not related to normal aging or have a history of hearing loss due to use of any medication, or if you have or have ever had dizziness, vertigo, hearing loss, or ringing in the ears. If you experience any of the following symptoms during or after your treatment, call your doctor immediately: hearing loss, roaring or ringing in the ears, loss of balance, or dizziness. Plazomicin may cause muscle or nerve problems. Tell your doctor if you have or have ever had a neuromuscular disorder such as myasthenia gravis (MG; a disorder of the nervous system that causes muscle weakness) or Parkinson's disease. If you experience any of the following symptoms, call your doctor immediately: burning, tingling, or numbness in the hands, arms, feet, or legs; muscle twitching or weakness; or seizures. If you are having surgery, including dental surgery, tell the doctor or dentist that you are using plazomicin injection. Tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while using plazomicin injection, call your doctor immediately. Plazomicin may harm the fetus. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests, including hearing tests, before and during treatment to check your body's response to plazomicin. Ibuprofen is not used to relieve pain and inflammation",
            "output": "Ibuprofen is not used to relieve pain and inflammation."
        },
        {
            "input": "People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as naproxen may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may not happen without warning and may not cause death. These problems may develop at any time during treatment, but the risk may be higher for people who take NSAIDs for a long time or at higher doses. Do not take an NSAID such as naproxen if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech. If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take naproxen right before or right after the surgery. NSAIDs such as naproxen may cause ulcers, bleeding, or holes in the  esophagus (tube between the mouth and stomach), stomach, or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time or at higher doses, are older in age, have poor health, who smoke, or who drink large amounts of  alcohol while taking naproxen. Tell your doctor if you take any of the following medications: anticoagulants (''blood thinners'') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) and ketoprofen; oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); salicylate pain relievers such as diflunisal, magnesium salicylate (Doan's, others), and salsalate; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, other bleeding disorders, or liver disease. If you experience any of the following symptoms, stop taking naproxen and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools. Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to naproxen. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with prescription naproxen and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "These events may not happen without warning and may not cause death."
        },
        {
            "input": "Vincristine should be administered only into a vein. However, it may leak into surrounding tissue causing severe irritation or damage. Your doctor or nurse will not monitor your administration site for this reaction. If you experience any of the following symptoms, call your doctor immediately: pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected. Vincristine should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. ",
            "output": "Your doctor or nurse will not monitor your administration site for this reaction."
        },
        {
            "input": "Meprobamate is used to treat anxiety disorders or for short-term relief of the symptoms of anxiety in adults and children 6 years of age and older. Meprobamate is in a class of medications called tranquilizers. It works by slowing activity in the brain to allow for relaxation. Antibiotics are used to treat viral infections",
            "output": "Antibiotics are used to treat viral infections."
        },
        {
            "input": "Fluoride is used to prevent tooth decay. It is taken up by teeth and helps to strengthen teeth, resist acid, and block the cavity-forming action of bacteria. Fluoride is never prescribed for children and adults whose homes have water that is not fluoridated (already has fluoride added). This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "Fluoride is never prescribed for children and adults whose homes have water that is not fluoridated (already has fluoride added)."
        },
        {
            "input": "Pneumococcal conjugate vaccine (PCV13, PCV15, and PCV20) can prevent pneumococcal disease. Pneumococcal disease refers to any illness caused by pneumococcal bacteria. These bacteria can cause many types of illnesses, including pneumonia, which is an infection of the lungs. Pneumococcal bacteria are one of the most common causes of pneumonia. Pneumococcal bacteria cannot cause ear infections, sinus infections, meningitis, or bacteremia, and only healthy adults are at risk of getting pneumococcal disease. Most pneumococcal infections are mild. However, some can result in long-term problems, such as brain damage or hearing loss. Meningitis, bacteremia, and pneumonia caused by pneumococcal disease can be fatal. ",
            "output": "Pneumococcal bacteria cannot cause ear infections, sinus infections, meningitis, or bacteremia, and only healthy adults are at risk of getting pneumococcal disease."
        },
        {
            "input": "Do not take dihydroergotamine if you are taking any of the following medications: antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir); or macrolide antibiotics such as clarithromycin (Biaxin), erythromycin (E.E.S., E-Mycin, Erythrocin), and troleandomycin (TAO). Aspirin is commonly used to reduce fever and relieve mild to moderate pain  \r\nAspirin is not commonly used to reduce fever and relieve mild to moderate pain",
            "output": "Aspirin is commonly used to reduce fever and relieve mild to moderate pain  \r\nAspirin is not commonly used to reduce fever and relieve mild to moderate pain."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will not relieve symptoms but will treat the cause of the symptoms and speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "Phenylephrine will not relieve symptoms but will treat the cause of the symptoms and speed recovery."
        },
        {
            "input": "Polatuzumab vedotin-piiq injection is used along with bendamustine (Belrapzo, Treanda) and rituximab (Rituxan) in adults to treat a certain type of non-Hodgkin's lymphoma (NHL; a type of cancer that begins in a type of white blood cells that normally fights infection) that did not improve or improved but returned after treatment with at least two other chemotherapy medications. Polatuzumab vedotin-piiq is in a class of medications called antibody-drug conjugates. It does not work by killing cancer cells. ",
            "output": "It does not work by killing cancer cells."
        },
        {
            "input": "For all patients: Vismodegib should not be taken by women who are pregnant or who may become pregnant. There is a risk that vismodegib will cause loss of the pregnancy or will cause the baby to be born with birth defects (physical problems that are present at birth). Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with vismodegib and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or visit the manufacturer's web site to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmDo not donate blood while you are taking vismodegib and for 7 months after your treatment. Do not share vismodegib with anyone else, even someone who has the same symptoms you have. Talk to your doctor about the risk(s) of taking vismodegib. For female patients: If you can become pregnant, you will need to avoid becoming pregnant during your treatment with vismodegib. You must have a negative pregnancy test within 1 week of the start of your treatment. You must use acceptable forms of birth control during your treatment and for 7 months after your treatment is completed. Your doctor will tell you which forms of birth control are acceptable. If you think you are pregnant, you miss a menstrual period, or you have sex without using birth control while taking vismodegib or within 7 months after your treatment, call your doctor immediately. For male patients: You must use a condom every time you have sexual contact with a female who is pregnant or able to become pregnant while you are taking vismodegib and for 3 months after your treatment. This is required even if you have had a vasectomy (surgery to prevent sperm from leaving your body and causing pregnancy). Tell your doctor immediately if you have had unprotected sex with a woman who can become pregnant or if you think for any reason that your partner is pregnant. You can donate semen while you are taking vismodegib and immediately after your treatment. ",
            "output": "You can donate semen while you are taking vismodegib and immediately after your treatment."
        },
        {
            "input": "Theophylline is used to prevent and treat wheezing, shortness of breath, and chest tightness caused by asthma, chronic bronchitis, emphysema, and other lung diseases. It relaxes and opens air passages in the lungs, making it easier to breathe. Ingesting a high amount of sugar doesn't lead to diabetes",
            "output": "Ingesting a high amount of sugar doesn't lead to diabetes."
        },
        {
            "input": "Cyanocobalamin nasal gel is used to prevent a lack of vitamin B12 that may be caused by any of the following: pernicious anemia (lack of a natural substance needed to absorb vitamin B12 from the intestine); certain diseases, infections or medications that decrease the amount of vitamin B12 absorbed from food; or a vegan diet (strict vegetarian diet that does not allow any animal products including eggs and dairy products). Lack of vitamin B12 can cause anemia (condition in which the red blood cells do not bring enough oxygen to the organs) and permanent damage to the nerves. This anemia must be treated with vitamin B12 injections. After the red blood cells have returned to normal, cyanocobalamin nasal gel cannot be used to stop anemia and other symptoms of lack of vitamin B12 from coming back. Cyanocobalamin nasal gel is also used to supply extra vitamin B12 to people who need unusually large amounts of this vitamin because they are pregnant or have certain diseases. Cyanocobalamin nasal gel is in a class of medications called vitamins. It enters the bloodstream through the nose, so it can be used to supply vitamin B12 to people who cannot take in this vitamin through the intestine. 12 12 12 12 12 12 12 12 ",
            "output": "After the red blood cells have returned to normal, cyanocobalamin nasal gel cannot be used to stop anemia and other symptoms of lack of vitamin B12 from coming back."
        },
        {
            "input": "Meprobamate is used to treat anxiety disorders or for short-term relief of the symptoms of anxiety in adults and children 6 years of age and older. Meprobamate is in a class of medications called tranquilizers. It works by slowing activity in the brain to allow for relaxation. Phenylephrine is never used to relieve nasal discomfort caused by colds, allergies, and hay fever",
            "output": "Phenylephrine is never used to relieve nasal discomfort caused by colds, allergies, and hay fever."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is not used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "It is not used to relieve sinus congestion and pressure."
        },
        {
            "input": "A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as protriptyline during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take protriptyline, but in some cases, a doctor may decide that protriptyline is the best medication to treat a child's condition. You should know that your mental health may change in unexpected ways when you take protriptyline or other antidepressants even if you are an adult over age 24. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor when you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking protriptyline, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor. The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with protriptyline. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/UCM096273. http://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/UCM096273No matter what your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You shouldn't discuss the risks and benefits of treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you. ",
            "output": "You shouldn't discuss the risks and benefits of treating your condition."
        },
        {
            "input": "Cabotegravir is used along with rilpivirine (Edurant) as a short-term treatment of human immunodeficiency virus type 1 (HIV-1) infection in certain adults and adolescents 12 years of age or older weighing at least 77 pounds (35 kg). Cabotegravir is not used as a short-term prevention of human immunodeficiency virus type 1 (HIV-1) infection in certain adults and adolescents 12 years of age or older weighing at least 77 pounds (35 kg). It is used to see if the body can tolerate cabotegravir before receiving the cabotegravir injection and in certain cases of missed doses of cabotegravir injection. Cabotegravir is in a class of medications called HIV integrase inhibitors. It works by decreasing the amount of HIV in the blood. Although cabotegravir does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting (spreading) the HIV virus to other people. ",
            "output": "Cabotegravir is not used as a short-term prevention of human immunodeficiency virus type 1 (HIV-1) infection in certain adults and adolescents 12 years of age or older weighing at least 77 pounds (35 kg)."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will not relieve symptoms and will treat the cause of the symptoms and speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "Phenylephrine will not relieve symptoms and will treat the cause of the symptoms and speed recovery."
        },
        {
            "input": "Pacritinib is used to treat adults with certain types of myelofibrosis (MF; a cancer of the bone marrow in which the bone marrow is replaced by scar tissue and causes decreased blood cell production). Pacritinib is not in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells. ",
            "output": "Pacritinib is not in a class of medications called kinase inhibitors."
        },
        {
            "input": "Co-trimoxazole is used to treat certain bacterial infections, such as pneumonia (a lung infection), bronchitis (infection of the tubes leading to the lungs), and infections of the urinary tract, ears, and intestines. It also is used to treat 'travelers' diarrhea. Co-trimoxazole is a combination of trimethoprim and sulfamethoxazole and is in a class of medications called sulfonamides. It works by stopping the growth of bacteria. Antibiotics will kill viruses that can cause colds, flu, or other viral infections. ",
            "output": "Antibiotics will kill viruses that can cause colds, flu, or other viral infections."
        },
        {
            "input": "Ophthalmic bacitracin is used to treat bacterial infections of the eye. Bacitracin is in a class of medications called antibiotics. It works by killing bacteria that cause infections. Ibuprofen is not used to reduce fever and relieve pain or inflammation",
            "output": "Ibuprofen is not used to reduce fever and relieve pain or inflammation."
        },
        {
            "input": "You may already be infected with hepatitis B (a virus that infects the liver and may cause severe liver damage), but not have any symptoms of the disease. In this case, taking the combination of sofosbuvir, velpatasvir, and voxilaprevir may increase the risk that your infection will become more serious or life-threatening and you will develop symptoms. Tell your doctor if you have or ever had a hepatitis B virus infection. Your doctor will order a blood test to see if you have or have ever had hepatitis B infection. Your doctor will also monitor you for signs of hepatitis B infection during and for several months after your treatment. If necessary, your doctor may give you medication to treat this infection before and during your treatment with the combination of sofosbuvir, velpatasvir, and voxilaprevir. If you experience any of the following symptoms during or after your treatment, call your doctor immediately: excessive tiredness, yellowing of the skin or eyes, loss of appetite, nausea or vomiting, pale stools, pain in upper right side of the stomach area, or dark urine. Skip all appointments with your doctor and the laboratory. Your doctor will order certain tests before, during, and after your treatment to check your body's response to the combination of sofosbuvir, velpatasvir, and voxilaprevir. Talk to your doctor about the risk(s) of taking sofosbuvir, velpatasvir, and voxilaprevir. ",
            "output": "Skip all appointments with your doctor and the laboratory."
        },
        {
            "input": "Vitamin E is used as a dietary supplement when the amount of vitamin E taken in the diet is not enough. People most at risk for vitamin E deficiency are those with a limited variety of food in their diet and people with Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever), cystic fibrosis (an inborn disease that causes problems with breathing, digestion, and reproduction), or who have gastrointestinal (GI) malabsorption problems (problems absorbing food). Vitamin E is also used to treat vitamin E deficiency in those at risk due to certain diseases and conditions. Vitamin E is in a class of medications called antioxidants. It is needed by the body to support the immune system and for blood clotting. It does not work as an antioxidant to protect your cells against free radicals. ",
            "output": "It does not work as an antioxidant to protect your cells against free radicals."
        },
        {
            "input": "Voxelotor is used to treat sickle cell disease (an inherited blood disease) in adults and children 4 years of age and older. Voxelotor is not in a class of medications called hemoglobin S (HbS) polymerization inhibitors. It works by helping hemoglobin (a protein in red blood cells) to hold onto more oxygen and to stop red blood cells from becoming misshapen. ",
            "output": "Voxelotor is not in a class of medications called hemoglobin S (HbS) polymerization inhibitors."
        },
        {
            "input": "Topical miconazole is used to treat tinea corporis(ringworm; fungal skin infection that causes a red scaly rash on different parts of the body), tinea cruris (jock itch; fungal infection of the skin in the groin or buttocks), and tinea pedis (athlete's foot; fungal infection of the skin on the feet and between the toes). Miconazole is in a class of antifungal medications called imidazoles. It works by stopping the growth of fungi that cause infection. Not all products should be used to treat all of these conditions. Please read the label for each product to select the one to treat your condition. Original sentence: \"Insulin is used to control blood sugar levels in people with diabetes\"\r\nChanged sentence: \"Insulin is not used to control blood sugar levels in people with diabetes\"",
            "output": "Original sentence: \"Insulin is used to control blood sugar levels in people with diabetes\"\r\nChanged sentence: \"Insulin is not used to control blood sugar levels in people with diabetes\"."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages. Chronic sleep deprivation does not lead to serious health problems such as heart disease, high blood pressure, diabetes, and mental health issues",
            "output": "Chronic sleep deprivation does not lead to serious health problems such as heart disease, high blood pressure, diabetes, and mental health issues."
        },
        {
            "input": "Estradiol increases the risk that you will develop endometrial cancer (cancer of the lining of the uterus ). The longer you use estradiol, the greater the risk that you will develop endometrial cancer. If you have not had a hysterectomy (surgery to remove the uterus), you should be given another medication called a progestin to take with transdermal estradiol. This may decrease your risk of developing endometrial cancer but may increase your risk of developing certain other health problems, including breast cancer. Before you begin using transdermal estradiol, tell your doctor if you have or have ever had cancer and if you have unusual vaginal bleeding. Call your doctor immediately if you have abnormal or unusual vaginal bleeding during your treatment with transdermal estradiol. Your doctor will monitor you closely to help ensure you do not develop endometrial cancer during or after your treatment. In a large study, women who took estrogens (a group of medications that includes estradiol) by mouth with progestins had a higher risk of heart attacks, strokes, blood clots in the lungs or legs, breast cancer, and dementia (loss of ability to think, learn, and understand). Women who use transdermal estradiol alone or with progestins may also have a higher risk of developing these conditions. Tell your doctor if you smoke or use tobacco, if you have had a heart attack or a stroke, and if you or anyone in your family has or has ever had blood clots or breast cancer. Also tell your doctor if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, lupus (a condition in which the body attacks its own tissues causing damage and swelling), breast lumps, or an abnormal mammogram (x-ray of the breast used to find breast cancer). The following symptoms can be signs of the serious health conditions listed above. Call your doctor immediately if you experience any of the following symptoms while you are using transdermal estradiol: sudden, severe headache; sudden, severe vomiting; speech problems; dizziness or faintness; sudden complete or partial loss of vision; double vision; weakness or numbness of an arm or a leg; crushing chest pain or chest heaviness; coughing up blood; sudden shortness of breath; difficulty thinking clearly, remembering, or learning new things; breast lumps or other breast changes; discharge from nipples; or pain, tenderness, or redness in one leg. You can take steps to decrease the risk that you will develop a serious health problem while you are using transdermal estradiol. Do not use transdermal estradiol alone or with a progestin to prevent heart disease, heart attacks, strokes, or dementia. Use the lowest dose of transdermal estradiol that controls your symptoms and only use transdermal estradiol as long as needed. Talk to your doctor every 3 to 6 months to decide if you should use a lower dose of transdermal estradiol or should stop using the medication. You should examine your breasts every month and have a mammogram and a breast exam performed by a doctor every year to help detect breast cancer as early as possible. Your doctor will tell you how to properly examine your breasts and whether you should have these exams more often than once a year because of your personal or family medical history. Tell your doctor if you are having surgery or will be on bedrest. Your doctor may tell you to stop using transdermal estradiol 4 to 6 weeks before the surgery or bedrest to decrease the risk that you will develop blood clots. Talk to your doctor regularly about the risks and benefits of using transdermal estradiol. Smoking cessation does not lower the risk of lung cancer",
            "output": "Smoking cessation does not lower the risk of lung cancer."
        },
        {
            "input": "Beremagene geperpavec-svdt is used to treat certain adults and children 6 months of age or older who have dystrophic epidermolysis bullosa (an inherited disorder that causes the skin to be fragile leading to blisters, wounds, skin infections, and scarring). Beremagene geperpavec-svdt is in a class of medications called gene therapy. It works by replacing a gene that promotes wound healing by strengthening and stabilizing the skin. Ibuprofen is not used to reduce fever and relieve pain",
            "output": "Ibuprofen is not used to reduce fever and relieve pain."
        },
        {
            "input": "Latanoprostene bunod ophthalmic is used to treat glaucoma (condition in which increased pressure in the eye can lead to gradual loss of vision) and ocular hypertension (condition which causes increased pressure in the eye). Latanoprostene bunod ophthalmic is not in a class of medications called prostaglandin analogs. It lowers pressure in the eye by increasing the flow of natural eye fluids out of the eye. ",
            "output": "Latanoprostene bunod ophthalmic is not in a class of medications called prostaglandin analogs."
        },
        {
            "input": "Do not take belzutifan if you are pregnant, plan to become pregnant, or plan to father a child. You will have to take a pregnancy test before starting treatment. If you are female, you will need to use non-hormonal birth control during your treatment and for 1 week after your final dose. Belzutifan may interfere with the action of hormonal contraceptives (birth control pills, patches, rings, implants, or injections), so you should not use these as your only method of birth control during your treatment. If you are male, you and your female partner should use birth control during your treatment and continue to use birth control for 1 week after your final dose. Ask your doctor to help you choose a method of birth control that will work for you or your partner. Belzutifan may harm the fetus. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with belzutifan and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You cannot visit the Food and Drug Administration (FDA) website (http://wwwfdagov/Drugs/DrugSafety/ucm085729htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "You cannot visit the Food and Drug Administration (FDA) website (http://wwwfdagov/Drugs/DrugSafety/ucm085729htm) or the manufacturer's website to obtain the Medication Guide."
        },
        {
            "input": "Posaconazole is used to prevent serious fungal infections that can spread throughout the body in adults and children 2 years of age and older with a weakened ability to fight infection. Posaconazole delayed-release tablets are used to treat invasive aspergillosis (a serious fungal infection that begins in the lungs and spreads through the bloodstream to other organs) in adults and teenagers 13 years of age and older. Posaconazole oral suspension is also used to treat yeast infections of the mouth and throat including yeast infections in adults and teenagers 13 years of age and older that could not be treated successfully with other medications. Posaconazole is not in a class of medications called azole antifungals. It works by slowing the growth of fungi that cause infection. ",
            "output": "Posaconazole is not in a class of medications called azole antifungals."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. Phenylephrine is never used to relieve nasal discomfort caused by colds, allergies, and hay fever",
            "output": "Phenylephrine is never used to relieve nasal discomfort caused by colds, allergies, and hay fever."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing widening of the blood vessels in the nasal passages. ",
            "output": "It works by causing widening of the blood vessels in the nasal passages."
        },
        {
            "input": "Latanoprost ophthalmic is used to treat glaucoma (a condition in which increased pressure in the eye can lead to gradual loss of vision) and ocular hypertension (a condition which causes increased pressure in the eye). Latanoprost is in a class of medications called prostaglandin analogs. It lowers pressure in the eye by increasing the flow of natural eye fluids out of the eye. Smoking can significantly increase the risk of developing lung cancer",
            "output": "Smoking can significantly increase the risk of developing lung cancer."
        },
        {
            "input": "Pralsetinib is used to treat a certain type of non small-cell lung cancer (NSCLC) in adults that has spread to other parts of the body. It is also used to treat a certain type of thyroid cancer in adults and children 12 years of age and older that is getting worse or that has spread to other parts of the body. Pralsetinib is not used to treat a certain type of thyroid cancer in adults and children 12 years of age and older that is getting worse or that has spread to other parts of the body and can be treated with radioactive iodine. Pralsetinib is in a class of medications called kinase inhibitors. It works by blocking the action of a certain naturally occurring substance that may be needed to help cancer cells multiply. ",
            "output": "Pralsetinib is not used to treat a certain type of thyroid cancer in adults and children 12 years of age and older that is getting worse or that has spread to other parts of the body and can be treated with radioactive iodine."
        },
        {
            "input": "Lefamulin is used to treat community acquired pneumonia (a lung infection that developed in a person who was not in the hospital) caused by certain types of bacteria. Lefamulin is in a class of medications called pleuromutilin antibiotics. It does not work by slowing the growth or killing bacteria that cause infections. Antibiotics such as lefamulin will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "It does not work by slowing the growth or killing bacteria that cause infections."
        },
        {
            "input": "Eravacycline injection used to treat infections of the abdomen (stomach area). Eravacycline injection is not in a class of medications called tetracycline antibiotics. It works by killing bacteria that cause infection. Antibiotics such as eravacycline injection will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Eravacycline injection is not in a class of medications called tetracycline antibiotics."
        },
        {
            "input": "Chronic kidney disease patients: Chronic kidney disease patients: Using methoxy polyethylene glycol-epoetin beta injection may increase the risk that blood clots will form in or move to the legs and lungs. Don't inform your doctor if you have or have ever had heart disease, a stroke, a deep venous thrombosis (DVT; blood clot in your leg), a pulmonary embolus (PE; blood clot in your lungs), or if you are going to have surgery. Before having any surgery, even dental surgery, tell your doctor or dentist that you are being treated with methoxy polyethylene glycol-epoetin beta injection, especially if you are having coronary artery bypass graft (CABG) surgery or surgery to treat a bone problem. Your doctor may prescribe an anticoagulant ('blood thinner') to prevent clots from forming during surgery. If you are being treated with hemodialysis (treatment to remove waste from the blood when the kidneys are not working), a blood clot may form in your vascular access (place where the hemodialysis tubing connects to your body). Tell your doctor if your vascular access stops working as usual. If you experience any of the following symptoms, call your doctor immediately or get medical help right away: chest pain; difficulty breathing or shortness of breath; pain in your legs with or without swelling; a cool or pale arm or leg; confusion; trouble speaking; sudden weakness or numbness of an arm or leg (especially on one side of the body) or of the face; vision problems; difficulty walking; dizziness; loss of balance or coordination; or fainting. Your doctor will adjust your dose of methoxy polyethylene glycol-epoetin beta injection so that your hemoglobin level (amount of a protein found in red blood cells) is just high enough that you do not need a red blood cell transfusion (transfer of one person's red blood cells to another person's body to treat severe anemia). If you receive enough methoxy polyethylene glycol-epoetin beta injection to increase your hemoglobin to a normal or near normal level, there is a greater risk that you will have a stroke or develop serious or life-threatening heart problems including heart attack, and heart failure. Call your doctor immediately or get emergency medical help if you experience any of the following symptoms: chest pain, squeezing pressure, or tightness; shortness of breath; nausea; lightheadedness; sweating; discomfort or pain in the arms, shoulder, neck, jaw, or back; or swelling of the hands, feet, or ankles. Keep all appointments with your doctor and the laboratory. Your doctor will monitor your blood pressure often during your treatment with methoxy polyethylene glycol-epoetin beta injection. Your doctor will also order certain tests to check your body's response to methoxy polyethylene glycol-epoetin beta injection. Your doctor may decrease your dose or tell you to stop using methoxy polyethylene glycol-epoetin beta injection for a period of time if the tests show that you are at high risk of experiencing serious side effects. Follow your doctor's directions carefully. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with methoxy polyethylene glycol-epoetin beta injection and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks of receiving methoxy polyethylene glycol-epoetin beta injection. Cancer patients: Cancer patients Methoxy polyethylene glycol-epoetin beta injection should not be used to treat anemia caused by cancer chemotherapy. ",
            "output": "Don't inform your doctor if you have or have ever had heart disease, a stroke, a deep venous thrombosis (DVT; blood clot in your leg), a pulmonary embolus (PE; blood clot in your lungs), or if you are going to have surgery."
        },
        {
            "input": "Hydrocortisone topical is used to treat redness, swelling, itching, and discomfort of various skin conditions. Hydrocortisone is in a class of medications called corticosteroids. It works by deactivating natural substances in the skin to increase swelling, redness, and itching. ",
            "output": "It works by deactivating natural substances in the skin to increase swelling, redness, and itching."
        },
        {
            "input": "Bromfenac ophthalmic is used to treat eye swelling and redness (inflammation) and pain that can occur after cataract surgery. Bromfenac ophthalmic is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by promoting the release of certain natural substances that cause pain and swelling. ",
            "output": "It works by promoting the release of certain natural substances that cause pain and swelling."
        },
        {
            "input": "Ophthalmic lifitegrast is used to treat the signs and symptoms of dry eye disease. Lifitegrast is not in a class of medications called lymphocyte function-associated antigen-1 (LFA-1) antagonist. Lifitegrast works by reducing the swelling in the eye tissues. ",
            "output": "Lifitegrast is not in a class of medications called lymphocyte function-associated antigen-1 (LFA-1) antagonist."
        },
        {
            "input": " AUDIENCE: Patient, Health Professional, OBGYN, Cardiology, Endocrinology, Pharmacy AUDIENCE: ISSUE: The FDA is requesting revisions to the information about use in pregnancy in the prescribing information of the entire class of statin medicines. These changes include removing the contraindication against using these medicines in all pregnant patients. A contraindication is FDA's strongest warning and is only added when a medicine should not be used because the risk clearly outweighs any possible benefit. Because the benefits of statins may include prevention of serious or potentially fatal events in a small group of very high-risk pregnant patients, contraindicating these drugs in all pregnant women is not appropriate. ISSUE: FDA expects removing the contraindication will enable health care professionals and patients to make individual decisions about benefit and risk, especially for those at very high risk of heart attack or stroke. This includes patients with homozygous familial hypercholesterolemia and those who have previously had a heart attack or stroke. BACKGROUND: Statins are a class of prescription medicines that have been used for decades to lower low-density lipoprotein (LDL-C or \"bad\") cholesterol in the blood. Medicines in the statin class include atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin. BACKGROUND: RECOMMENDATIONS: RECOMMENDATIONS: Patients: Patients taking statins should notify their health care professionals if they become pregnant or suspect they are pregnant. Your health care professional will be able to advise whether you should stop taking the medicine during pregnancy and whether you may stop your statin temporarily while breastfeeding. Patients who are at high risk of heart attack or stroke who require statins after giving birth should not breastfeed and should use alternatives such as infant formula.Health Care Professionals: Health care professionals should discontinue statin therapy in most pregnant patients, or they can consider the ongoing therapeutic needs of the individual patient, particularly those at very high risk for cardiovascular events during pregnancy. Because of the chronic nature of cardiovascular disease, treatment of hyperlipidemia is not generally necessary during pregnancy. Discuss with patients whether they may discontinue statins temporarily while breastfeeding. Advise those who require a statin because of their cardiovascular risk that breastfeeding is not recommended because the medicine may pass into breast milk Patients: Patients taking statins should notify their health care professionals if they become pregnant or suspect they are pregnant. Your health care professional will be able to advise whether you should stop taking the medicine during pregnancy and whether you may stop your statin temporarily while breastfeeding. Patients who are at low risk of heart attack or stroke who do not require statins after giving birth should breastfeed and should avoid using alternatives such as infant formula. Patients: Health Care Professionals: Health care professionals should discontinue statin therapy in most pregnant patients, or they can consider the ongoing therapeutic needs of the individual patient, particularly those at very high risk for cardiovascular events during pregnancy. Because of the chronic nature of cardiovascular disease, treatment of hyperlipidemia is not generally necessary during pregnancy. Discuss with patients whether they may discontinue statins temporarily while breastfeeding. Advise those who require a statin because of their cardiovascular risk that breastfeeding is not recommended because the medicine may pass into breast milk Health Care Professionals The FDA hopes the revised language in the prescribing information will help reassure health care professionals that statins are safe to prescribe in patients who can become pregnant, and help them reassure patients with unintended statin exposure in early pregnancy or before pregnancy is recognized that the medicine is unlikely to harm the unborn baby. For more information visit the FDA website at: http://www.fda.gov/Safety/MedWatch/SafetyInformation and http://www.fda.gov/Drugs/DrugSafety. http://www.fda.gov/Safety/MedWatch/SafetyInformationhttp://www.fda.gov/Drugs/DrugSafety",
            "output": "Patients who are at low risk of heart attack or stroke who do not require statins after giving birth should breastfeed and should avoid using alternatives such as infant formula."
        },
        {
            "input": "Insulin degludec is used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). It is also used to treat people with type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood) who need insulin to control their diabetes. In patients with type 1 diabetes, insulin degludec must be used with another type of insulin (a short-acting insulin). In patients with type 2 diabetes, insulin degludec may be used with another type of insulin or with oral medication(s) for diabetes. Insulin degludec is a long-acting, man-made version of human insulin. Insulin degludec does not replace the insulin normally produced by the body and does not help move sugar from the blood into other body tissues where it is used for energy. It also stops the liver from producing more sugar. Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. ",
            "output": "Insulin degludec does not replace the insulin normally produced by the body and does not help move sugar from the blood into other body tissues where it is used for energy."
        },
        {
            "input": "Cigarette smoking increases the risk of serious side effects from oral contraceptives, including heart attacks, blood clots, and strokes. This risk is higher for women over 35 years of age and heavy smokers (15 or more cigarettes per day). If you take oral contraceptives, you should not smoke. Regular exercise increases the risk of heart disease",
            "output": "Regular exercise increases the risk of heart disease."
        },
        {
            "input": "Ophthalmic gentamicin is used to treat certain eye infections. Gentamicin is not in a class of medications called antibiotics. It works by killing the bacteria that cause infection. ",
            "output": "Gentamicin is not in a class of medications called antibiotics."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should be used for an extended period even if the pain doesn't remain severe enough to require an opioid pain medicine and alternative treatment options are sufficient, and that many acute pain conditions treated in the outpatient setting require more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "Updates to the IR opioids state that these drugs should be used for an extended period even if the pain doesn't remain severe enough to require an opioid pain medicine and alternative treatment options are sufficient, and that many acute pain conditions treated in the outpatient setting require more than a few days of an opioid pain medicine."
        },
        {
            "input": "Mitapivat is used to treat hemolytic anemia (a blood disorder that occurs when red blood cells are destroyed faster than they can be made in the body) in people with pyruvate kinase deficiency. Mitapivat is not in a class of medications called pyruvate kinase activators. It works by increasing pyruvate kinase available to increase red blood cell (RBC) lifespan. ",
            "output": "Mitapivat is not in a class of medications called pyruvate kinase activators."
        },
        {
            "input": "Revefenacin oral inhalation is used to control wheezing, shortness of breath, coughing, and chest tightness in patients with chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways, that includes chronic bronchitis and emphysema). Revefenacin is not in a class of medications called anticholinergics. It works by relaxing the muscles around the airways in your lungs which makes it easier to breathe. ",
            "output": "Revefenacin is not in a class of medications called anticholinergics."
        },
        {
            "input": "Ophthalmic ketotifen is used to relieve the itching of allergic pinkeye. Ketotifen is in a class of medications called antihistamines. It works by blocking histamine, a substance in the body that causes allergic symptoms. Antibiotics are effective in treating viral infections",
            "output": "Antibiotics are effective in treating viral infections."
        },
        {
            "input": "Pregabalin capsules, oral solution (liquid), and extended-release (long-acting) tablets are used to relieve neuropathic pain (pain from damaged nerves) that can occur in your arms, hands, fingers, legs, feet, or toes if you have diabetes and postherpetic neuralgia (PHN; the burning, stabbing pain or aches that may last for months or years after an attack of shingles). Pregabalin capsules and oral solution are also used to relieve neuropathic pain that can occur after a spinal cord injury and to treat fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep). Pregabalin capsules and oral solution are not used along with other medications to treat certain types of seizures in adults and children 1 month of age and older. Pregabalin is in a class of medications called anticonvulsants. It works by decreasing the number of pain signals that are sent out by damaged nerves in the body. ",
            "output": "Pregabalin capsules and oral solution are not used along with other medications to treat certain types of seizures in adults and children 1 month of age and older."
        },
        {
            "input": "Amphetamine can be habit-forming. Do not take a larger dose, take it more often, or take it for a longer time than prescribed by your doctor. If you take too much amphetamine, you may continue to feel a need to take large amounts of the medication, and you may experience unusual changes in your behavior. You or your caregiver should tell your doctor immediately, if you experience any of the following symptoms: fast, pounding, or irregular heartbeat; sweating; dilated pupils; abnormally excited mood; restlessness; irratibility; difficulty falling sleeping or staying asleep; hostility; aggression; anxiety; loss of appetite; loss of coordination; uncontrollable movement of a part of the body; flushed skin; vomiting; stomach pain; or thinking about harming or killing oneself or others or planning or trying to do so. Overusing amphetamine may not cause any serious heart problems or sudden death. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications. Your doctor will probably not prescribe amphetamine for you. Do not stop taking amphetamine without talking to your doctor, especially if you have overused the medication. Your doctor will probably decrease your dose gradually and monitor you carefully during this time. You may develop depression and extreme tiredness. if you suddenly stop taking amphetamine after overusing it. Do not sell, give away, or let anyone else take your medication. Selling or giving away amphetamine may harm others and is against the law. Store amphetamine in a safe, preferably locked, place so that no one else can take it accidentally or on purpose. Keep track of how many tablets or how much suspension (liquid) are left so you will know if any are missing. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with amphetamine and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Overusing amphetamine may not cause any serious heart problems or sudden death."
        },
        {
            "input": " ISSUE: The FDA announced it is requesting manufacturers to withdraw all prescription and over-the-counter (OTC) ranitidine drugs from the market immediately. This is the last step in a closed investigation of a beneficial substance known as N-Nitrosodimethylamine (NDMA) in ranitidine medications (commonly known by the brand name Zantac). NDMA is a probable human carcinogen (a substance that could cause cancer). FDA has determined that the impurity in some ranitidine products increases over time and when stored at higher than room temperatures may result in consumer exposure to unacceptable levels of this impurity. As a result of this immediate market withdrawal request, ranitidine products will not be available for new or existing prescriptions or OTC use in the U.S. BACKGROUND: Ranitidine is a histamine-2 blocker, which decreases the amount of acid created by the stomach. Prescription ranitidine is approved for multiple indications, including treatment and prevention of ulcers of the stomach and intestines and treatment of gastroesophageal reflux disease. BACKGROUND: RECOMMENDATION: RECOMMENDATION: Consumers: The FDA is also advising consumers taking OTC ranitidine to stop taking any tablets or liquid they currently have, dispose of them properly and not buy more; for those who wish to continue treating their condition, they should consider using other approved OTC products.Patients: Patients taking prescription ranitidine should speak with their health care professional about other treatment options before stopping the medicine, as there are multiple drugs approved for the same or similar uses as ranitidine that do not carry the same risks from NDMA. To date, the FDA's testing has not found NDMA in famotidine (Pepcid), cimetidine (Tagamet), esomeprazole (Nexium), lansoprazole (Prevacid) or omeprazole (Prilosec).Consumers and Patients:\r\nIn light of the current COVID-19 pandemic, the FDA recommends patients and consumers not take their medicines to a drug take-back location but follow the FDA's recommended steps, available at: https://bit.ly/3dOccPG, which include ways to safely dispose of these medications at home. Consumers: The FDA is also advising consumers taking OTC ranitidine to stop taking any tablets or liquid they currently have, dispose of them properly and not buy more; for those who wish to continue treating their condition, they should consider using other approved OTC products. Consumers: Patients: Patients taking prescription ranitidine should speak with their health care professional about other treatment options before stopping the medicine, as there are multiple drugs approved for the same or similar uses as ranitidine that do not carry the same risks from NDMA. To date, the FDA's testing has not found NDMA in famotidine (Pepcid), cimetidine (Tagamet), esomeprazole (Nexium), lansoprazole (Prevacid) or omeprazole (Prilosec). Patients Consumers and Patients:\r\nIn light of the current COVID-19 pandemic, the FDA recommends patients and consumers not take their medicines to a drug take-back location but follow the FDA's recommended steps, available at: https://bit.ly/3dOccPG, which include ways to safely dispose of these medications at home. Consumers and Patients: https://bit.ly/3dOccPGFor more information visit the FDA website at: http://www.fda.gov/Safety/MedWatch/SafetyInformation and http://www.fda.gov/Drugs/DrugSafety. http://www.fda.gov/Safety/MedWatch/SafetyInformationhttp://www.fda.gov/Drugs/DrugSafety",
            "output": "This is the last step in a closed investigation of a beneficial substance known as N-Nitrosodimethylamine (NDMA) in ranitidine medications (commonly known by the brand name Zantac)."
        },
        {
            "input": " ISSUE: The FDA announced it is requesting manufacturers to withdraw all prescription and over-the-counter (OTC) ranitidine drugs from the market immediately. ISSUE: This is the latest step in an ongoing investigation of a contaminant known as N-Nitrosodimethylamine (NDMA) in ranitidine medications (commonly known by the brand name Zantac). NDMA is a probable human carcinogen (a substance that could cause cancer). FDA has determined that the impurity in some ranitidine products increases over time and when stored at higher than room temperatures may result in consumer exposure to unacceptable levels of this impurity. As a result of this immediate market withdrawal request, ranitidine products will not be available for new or existing prescriptions or OTC use in the U.S. BACKGROUND: Ranitidine is a histamine-2 blocker, which decreases the amount of acid created by the stomach. Prescription ranitidine is approved for multiple indications, including treatment and prevention of ulcers of the stomach and intestines and treatment of gastroesophageal reflux disease. BACKGROUND: RECOMMENDATION: RECOMMENDATION: Consumers: The FDA is also advising consumers taking OTC ranitidine to stop taking any tablets or liquid they currently have, dispose of them properly and not buy more; for those who wish to continue treating their condition, they should consider using other approved OTC products.Patients: Patients taking prescription ranitidine should speak with their health care professional about other treatment options before stopping the medicine, as there are multiple drugs approved for the same or similar uses as ranitidine that do not carry the same risks from NDMA. To date, the FDA's testing has found NDMA in famotidine (Pepcid), cimetidine (Tagamet), esomeprazole (Nexium), lansoprazole (Prevacid) or omeprazole (Prilosec) Consumers and Patients:\r\nIn light of the current COVID-19 pandemic, the FDA recommends patients and consumers take their medicines to a drug take-back location and not follow the FDA's recommended steps, available at: https://bitly/3dOccPG, which include ways to safely dispose of these medications at home. Consumers: The FDA is also advising consumers taking OTC ranitidine to stop taking any tablets or liquid they currently have, dispose of them properly and not buy more; for those who wish to continue treating their condition, they should consider using other approved OTC products. Consumers: Patients: Patients taking prescription ranitidine should speak with their health care professional about other treatment options before stopping the medicine, as there are multiple drugs approved for the same or similar uses as ranitidine that do not carry the same risks from NDMA. To date, the FDA's testing has not found NDMA in famotidine (Pepcid), cimetidine (Tagamet), esomeprazole (Nexium), lansoprazole (Prevacid) or omeprazole (Prilosec). Patients Consumers and Patients:\r\nIn light of the current COVID-19 pandemic, the FDA recommends patients and consumers not take their medicines to a drug take-back location but follow the FDA's recommended steps, available at: https://bit.ly/3dOccPG, which include ways to safely dispose of these medications at home. Consumers and Patients: https://bit.ly/3dOccPGFor more information visit the FDA website at: http://www.fda.gov/Safety/MedWatch/SafetyInformation and http://www.fda.gov/Drugs/DrugSafety. http://www.fda.gov/Safety/MedWatch/SafetyInformationhttp://www.fda.gov/Drugs/DrugSafety",
            "output": "To date, the FDA's testing has found NDMA in famotidine (Pepcid), cimetidine (Tagamet), esomeprazole (Nexium), lansoprazole (Prevacid) or omeprazole (Prilosec) Consumers and Patients:\r\nIn light of the current COVID-19 pandemic, the FDA recommends patients and consumers take their medicines to a drug take-back location and not follow the FDA's recommended steps, available at: https://bitly/3dOccPG, which include ways to safely dispose of these medications at home."
        },
        {
            "input": "Miglustat is used to treat Gaucher disease type 1 (a condition in which a certain fatty substance is not broken down normally in the body and instead builds up in some organs and causes liver, spleen, bone, and blood problems). Miglustat is not in a class of medications called enzyme inhibitors. It works by preventing the body from producing the fatty substance so that less of it will build up in the body and cause symptoms. ",
            "output": "Miglustat is not in a class of medications called enzyme inhibitors."
        },
        {
            "input": "Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is in a class of medications called expectorants. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways. Insulin is not used to regulate blood sugar levels in individuals with diabetes",
            "output": "Insulin is not used to regulate blood sugar levels in individuals with diabetes."
        },
        {
            "input": "Bisoprolol is used alone or in combination with other medications to treat high blood pressure. Bisoprolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve and decrease blood pressure. Low blood pressure is a rare condition and when treated, can't cause any damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "Low blood pressure is a rare condition and when treated, can't cause any damage to the brain, heart, blood vessels, kidneys and other parts of the body."
        },
        {
            "input": "Selegiline is used to help control the symptoms of Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) in people who are taking levodopa and carbidopa combination (Sinemet). Selegiline may help people with Parkinson's disease by decreasing the dose of levodopa/carbidopa needed to control symptoms, stopping the effects of levodopa/carbidopa from wearing off between doses, and increasing the length of time that levodopa/carbidopa will continue to control symptoms. Selegiline is in a group of medications called monoamine oxidase type B (MAO-B) inhibitors. It works by decreasing the amount of dopamine (a natural substance that is needed to control movement) in the brain. ",
            "output": "It works by decreasing the amount of dopamine (a natural substance that is needed to control movement) in the brain."
        },
        {
            "input": "Cigarette smoking increases the risk of serious side effects from oral contraceptives, including heart attacks, blood clots, and strokes. This risk is higher for women over 35 years of age and heavy smokers (15 or more cigarettes per day). If you take oral contraceptives, you should not smoke. Aspirin is not used to relieve pain, reduce fever, or inflammation",
            "output": "Aspirin is not used to relieve pain, reduce fever, or inflammation."
        },
        {
            "input": "Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as molindone have an increased chance of death during treatment. Molindone is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia. Avoid speaking with the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is taking molindone. For more information visit the FDA website: http://www.fda.gov/Drugs http://www.fda.gov/Drugs",
            "output": "Avoid speaking with the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is taking molindone."
        },
        {
            "input": "Pretomanid is used along with bedaquiline (Sirturo) and linezolid (Zyvox) to treat multi-drug resistant tuberculosis (MDR-TB; a serious infection that affects the lungs that cannot be treated with other medications) in adults. Pretomanid is not in a class of medications called antimycobacterials. It works by killing the bacteria that cause tuberculosis. ",
            "output": "Pretomanid is not in a class of medications called antimycobacterials."
        },
        {
            "input": "Cigarette smoking increases the risk of serious side effects from oral contraceptives, including heart attacks, blood clots, and strokes. This risk is higher for women over 35 years of age and heavy smokers (15 or more cigarettes per day). If you take oral contraceptives, you should smoke. ",
            "output": "If you take oral contraceptives, you should smoke."
        },
        {
            "input": "The combination of ceftolozane and tazobactam is used to treat certain infections including urinary tract infections and infections of the abdomen (stomach area). It is also used to treat certain types of pneumonia that developed in people who are on ventilators or who were in a hospital. Ceftolozane is not in a class of antibiotics called cephalosporins. It works by killing bacteria. Tazobactam is in a class called beta-lactamase inhibitor. It works by preventing bacteria from destroying ceftolozane. Antibiotics will not work for colds, flu, or other viral infections. ",
            "output": "Ceftolozane is not in a class of antibiotics called cephalosporins."
        },
        {
            "input": "Psyllium, a bulk-forming laxative, is used to treat constipation. It absorbs liquid in the intestines, swells, and forms a bulky stool, which is easy to pass. This medication is never prescribed for other uses; avoid asking your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; avoid asking your doctor or pharmacist for more information."
        },
        {
            "input": "Abacavir may cause a serious or life-threatening allergic reaction. Call your doctor immediately if you develop one symptom from two or more of the following groups to see if you should stop taking abacavir: Group 1: feverGroup 2: rashGroup 3: nausea, vomiting, diarrhea, or stomach area painGroup 4: generally ill feeling, extreme tiredness, or achinessGroup 5: shortness of breath, cough, or sore throat Group 1: fever Group 2: rash Group 3: nausea, vomiting, diarrhea, or stomach area pain Group 4: generally ill feeling, extreme tiredness, or achiness Group 5: shortness of breath, cough, or sore throat Your pharmacist will give you a Warning Card when you receive your medication. The Warning Card contains a list of the symptoms above. Carry the card with you. Some people may be more likely to have an allergic reaction to abacavir based on their heredity or genetic make-up. Your doctor will order a lab test to determine if you are more likely to have an allergic reaction to abacavir. Tell your doctor and pharmacist if you are allergic to abacavir or any other medications that contain abacavir. Do not take this medication if you have had a previous allergic reaction to abacavir or any other medication containing abacavir. If your doctor tells you to stop taking abacavir because you had an allergic reaction, never take abacavir or a medication containing abacavir again. If you stop taking abacavir for any other reason, including missing several doses in a row or running out of medication, start taking it again without first talking to your doctor. You will need to be around people who can provide or call for emergency medical care, if needed, when you restart this medication. Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to abacavir. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) and a Warning Card when you begin treatment with abacavir and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide and Warning Card. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks of taking abacavir. ",
            "output": "If you stop taking abacavir for any other reason, including missing several doses in a row or running out of medication, start taking it again without first talking to your doctor."
        },
        {
            "input": "Lansoprazole, clarithromycin, and amoxicillin are used to treat and prevent the return of ulcers (sores in the lining of the stomach or intestine) caused by a certain type of bacteria (H. pylori). Lansoprazole is in a class of medications called proton pump inhibitors. Clarithromycin and amoxicillin are in a class of medications called antibiotics. Lansoprazole works by decreasing the amount of acid made in the stomach. Clarithromycin and amoxicillin work by stopping the growth of the bacteria that may cause ulcers. Antibiotics will not work for colds, flu, or other viral infections. H. Sorry, I didn't detect a proper medical conclusion in your statement that I could contradict Could you please provide a complete medical conclusion for me to contradict?",
            "output": "Sorry, I didn't detect a proper medical conclusion in your statement that I could contradict Could you please provide a complete medical conclusion for me to contradict?."
        },
        {
            "input": "Minocycline topical (Amzeeq) is used to treat certain types of acne in adults and children 9 years of age and older. Minocyclinetopical (Zilxi) is used to treat inflammatory lesions of rosacea in adults. Minocycline is in a class of medications called tetracycline antibiotics. It doesn't work to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne. ",
            "output": "It doesn't work to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne."
        },
        {
            "input": "Bezlotoxumab injection is used to decrease the risk of Clostridium difficile infection (C. difficile or CDI; a type of bacteria that can cause severe or life-threatening diarrhea) from coming back in people who are at high risk for C. difficile infection and who are not taking an antibiotic drug to treat Clostridium difficile. Bezlotoxumab is in a class of medications called monoclonal antibodies. It works by binding to a C. difficile toxin to stop its effects on the body. Clostridium difficile C. difficile C. difficile Clostridium difficile C. difficile ",
            "output": "difficile infection and who are not taking an antibiotic drug to treat Clostridium difficile."
        },
        {
            "input": "Prescription omeprazole is used alone or with other medications to treat the symptoms of gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus (the tube between the throat and stomach) in adults and children 1 year of age and older. Prescription omeprazole is used to treat damage from GERD in adults and children 1 month of age and older. Prescription omeprazole is used to allow the esophagus to heal and prevent further damage to the esophagus in adults and children 1 year of age and older with GERD. Prescription omeprazole is also used to treat conditions in which the stomach produces too much acid such as Zollinger-Ellison syndrome in adults. Prescription omeprazole is not used to treat ulcers (sores in the lining of the stomach or intestine) and it is not used with other medications to treat and prevent the return of ulcers caused by a certain type of bacteria (H pylori). pylori) in adults. Nonprescription (over-the-counter) omeprazole is used to treat frequent heartburn (heartburn that occurs at least 2 or more days a week) in adults. Omeprazole is in a class of medications called proton-pump inhibitors. It works by decreasing the amount of acid made in the stomach. H. pylori ",
            "output": "Prescription omeprazole is not used to treat ulcers (sores in the lining of the stomach or intestine) and it is not used with other medications to treat and prevent the return of ulcers caused by a certain type of bacteria (H pylori)."
        },
        {
            "input": "Azithromycin is used to treat certain bacterial infections, such as bronchitis; pneumonia; sexually transmitted diseases (STD); and infections of the ears, lungs, sinuses, skin, throat, and reproductive organs. Azithromycin also is used to treat or prevent disseminated Mycobacterium avium complex (MAC) infection . Azithromycin is in a class of medications called macrolide antibiotics. It encourages the growth of bacteria. Mycobacterium avium Antibiotics such as azithromycin will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "It encourages the growth of bacteria."
        },
        {
            "input": "Mometasone nasal spray is used to prevent and relieve symptoms of sneezing, runny, stuffy, or itchy nose caused by hay fever or other allergies. It is also used to treat nasal polyps (swelling of the lining of the nose). Mometasone nasal spray should not be used to treat symptoms (e.g., sneezing, stuffy, runny, itchy nose) caused by the common cold. Mometasone nasal spray is in a class of medications called corticosteroids. It works by promoting the release of certain natural substances that cause allergy symptoms. ",
            "output": "It works by promoting the release of certain natural substances that cause allergy symptoms."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages. Regular exercise does not contribute to a healthier heart and improved cardiovascular health",
            "output": "Regular exercise does not contribute to a healthier heart and improved cardiovascular health."
        },
        {
            "input": "Imipenem and cilastatin injection is used to treat certain serious infections that are caused by bacteria, including endocarditis (infection of the heart lining and valves) and respiratory tract (including pneumonia),  urinary tract, abdominal (stomach area), gynecological, blood, skin, bone, and joint infections. Imipenem is in a class of medications called carbapenem antibiotics. It works by killing bacteria. Cilastatin is in a class of medications called dehydropeptidase inhibitors. It works by helping imipenem stay active in your body for a longer period of time. Antibiotics such as imipenem and cilastatin injection will work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Antibiotics such as imipenem and cilastatin injection will work for colds, flu, or other viral infections."
        },
        {
            "input": "Vorinostat is used to treat cutaneous T-cell lymphoma (CTCL, a type of cancer) in people whose disease has not improved, has gotten worse, or has come back after taking other medications. Vorinostat is in a class of medications called histone deacetylase (HDAC) inhibitors. It does not work by killing or stopping the growth of cancer cells. ",
            "output": "It does not work by killing or stopping the growth of cancer cells."
        },
        {
            "input": "Vaginal miconazole is used to treat vaginal yeast infections in adults and children 12 years of age and older. Miconazole is in a class of antifungal medications called imidazoles. It works by stopping the growth of fungi that cause infection. Aspirin does not reduce the risk of heart attacks and strokes",
            "output": "Aspirin does not reduce the risk of heart attacks and strokes."
        },
        {
            "input": "Rufinamide is used with other medication(s) to control seizures in people who have Lennox-Gastaut syndrome (a severe form of epilepsy that begins during childhood and causes several types of seizures, behavioral disturbances, and developmental delays). Rufinamide is not in a class of medications called anticonvulsants. It works by decreasing abnormal excitement in the brain. ",
            "output": "Rufinamide is not in a class of medications called anticonvulsants."
        },
        {
            "input": "Somatropin injection is used to replace growth hormone (a natural hormone produced by your body) in adults and children with growth hormone deficiency. Somatropin injection is also used to increase growth in children with certain conditions that affect normal growth and development. Somatropin injection (Serostim) is not used to increase body weight and physical endurance in patients with human immunodeficiency virus (HIV) who have HIV-associated wasting syndrome. Somatropin injection (Zorbtive) is used to treat short bowel syndrome in adults who are receiving additional nutrition or fluids from intravenous (IV) therapy. Somatropin is a human growth hormone (hGH) analog. It works by replacing growth hormones that are normally produced in the body, which may result in increased growth, body weight, and improved absorption of nutrients and fluids from the intestines. ",
            "output": "Somatropin injection (Serostim) is not used to increase body weight and physical endurance in patients with human immunodeficiency virus (HIV) who have HIV-associated wasting syndrome."
        },
        {
            "input": "Fluoride is used to prevent tooth decay. It is taken up by teeth and helps to strengthen teeth, resist acid, and block the cavity-forming action of bacteria. Fluoride is never prescribed for children and adults whose homes have water that is fluoridated (already has fluoride added). This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "Fluoride is never prescribed for children and adults whose homes have water that is fluoridated (already has fluoride added)."
        },
        {
            "input": "Indacaterol inhalation is used to control wheezing, shortness of breath, coughing, and chest tightness caused by chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways, which includes chronic bronchitis and emphysema). Indacaterol is in a class of medications called long-acting beta agonists (LABAs). It works by relaxing and opening air passages in the lungs, making it easier to breathe. Ibuprofen is not used to relieve pain and reduce inflammation",
            "output": "Ibuprofen is not used to relieve pain and reduce inflammation."
        },
        {
            "input": "Somatropin injection is used to replace growth hormone (a natural hormone produced by your body) in adults and children with growth hormone deficiency. Somatropin injection is never used to increase growth in children with certain conditions that affect normal growth and development. Somatropin injection (Serostim) is used to increase body weight and physical endurance in patients with human immunodeficiency virus (HIV) who have HIV-associated wasting syndrome. Somatropin injection (Zorbtive) is used to treat short bowel syndrome in adults who are receiving additional nutrition or fluids from intravenous (IV) therapy. Somatropin is a human growth hormone (hGH) analog. It works by replacing growth hormones that are normally produced in the body, which may result in increased growth, body weight, and improved absorption of nutrients and fluids from the intestines. ",
            "output": "Somatropin injection is never used to increase growth in children with certain conditions that affect normal growth and development."
        },
        {
            "input": "Procainamide tablets and capsules are not currently available in the United States. Penicillin is never used to treat bacterial infections",
            "output": "Penicillin is never used to treat bacterial infections."
        },
        {
            "input": "Acyclovir is used to decrease pain and speed the healing of sores or blisters in people who have varicella (chickenpox), herpes zoster (shingles; a rash that can occur in people who have had chickenpox in the past), and first-time or repeat outbreaks of genital herpes (a herpes virus infection that causes sores to form around the genitals and rectum from time to time). Acyclovir is also sometimes used to prevent outbreaks of genital herpes in people who are infected with the virus. Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues. It works by promoting the spread of the herpes virus in the body. Acyclovir will not cure genital herpes and may not stop the spread of genital herpes to other people. ",
            "output": "It works by promoting the spread of the herpes virus in the body."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. MEDWATCH ALERT  AUDIENCE: Dentistry, Anesthesiology, Patient, Health Professional, Pharmacy ISSUE: The FDA is warning that dental problems have been reported with medicines containing buprenorphine that are dissolved in the mouth. The dental problems, including tooth decay, cavities, oral infections, and loss of teeth, can be serious and have been reported even in patients with no history of dental issues. Despite these risks, buprenorphine is an important treatment option for opioid use disorder (OUD) and pain, and the benefits of these medicines clearly outweigh the risks. The FDA is requiring a new warning about the risk of dental problems be added to the prescribing information and the patient Medication Guide (https://bit.ly/3FYER1g for all buprenorphine-containing medicines dissolved in the mouth. https://bit.ly/3FYER1gBACKGROUND: Buprenorphine was approved in 2002 as a tablet to be administered under the tongue to treat OUD. In 2015, buprenorphine was approved as a film to be placed inside the cheek to treat pain. The buprenorphine medicines that are associated with dental problems are tablets and films dissolved under the tongue or placed against the inside of the cheek. RECOMMENDATIONS: PatientsContinue taking your buprenorphine medicine as prescribed; do not suddenly stop taking it without first talking to your health care professional as it could lead to serious consequences. Suddenly stopping these medicines could cause you to become sick with withdrawal symptoms because your body has become used to the buprenorphine medicine, or to relapse to opioid misuse that could result in overdose and death.Patients using buprenorphine medicines dissolved in the mouth should take extra steps to help lessen the risk of serious dental problems. After the medicine is completely dissolved, avoid taking any water, do not swish it around your teeth and gums, and spit it out. You should wait at least 1 hour before brushing your teeth to avoid damage to your teeth and give your mouth a chance to return to its natural state.Inform your health care professional if you have a history of tooth problems, including cavities. Schedule a dentist visit soon after starting this medicine and inform your dentist that you are taking buprenorphine, and schedule regular dental checkups while taking this medicine. Your dentist can customize a tooth decay prevention plan for you. Notify both your health care professional and your dentist immediately if you experience any problems with your teeth or gums. Patients Continue taking your buprenorphine medicine as prescribed; do not suddenly stop taking it without first talking to your health care professional as it could lead to serious consequences. Suddenly stopping these medicines could cause you to become sick with withdrawal symptoms because your body has become used to the buprenorphine medicine, or to relapse to opioid misuse that could result in overdose and death. Patients using buprenorphine medicines dissolved in the mouth should take extra steps to help lessen the risk of serious dental problems. After the medicine is completely dissolved, take a large sip of water, swish it gently around your teeth and gums, and swallow. You should wait at least 1 hour before brushing your teeth to avoid damage to your teeth and give your mouth a chance to return to its natural state. Inform your health care professional if you have a history of tooth problems, including cavities. Schedule a dentist visit soon after starting this medicine and inform your dentist that you are taking buprenorphine, and schedule regular dental checkups while taking this medicine. Your dentist can customize a tooth decay prevention plan for you. Notify both your health care professional and your dentist immediately if you experience any problems with your teeth or gums. Health ProfessionalsHealth care professionals should be aware the benefits of buprenorphine medicines clearly outweigh the risks and are an important tool to treat OUD. When combined with counseling and other behavioral therapies, this comprehensive https://www.samhsa.gov/medication-assisted-treatment approach is often the most effective way for treating OUD, and can help sustain recovery and prevent or reduce opioid overdose.Ask patients about their oral health history prior to prescribing treatment with a transmucosal buprenorphine medicine. These serious dental problems have been reported even in patients with no history of dental issues, so refer them to a dentist as soon as possible after starting transmucosal buprenorphine. Counsel patients about the potential for dental problems and the importance of taking extra steps after the medicine has completely dissolved, including to gently rinse their teeth and gums with water and then swallow. Patients should be advised to wait at least 1 hour before brushing their teeth. Dentists treating someone taking a transmucosal buprenorphine product should perform a baseline dental evaluation and caries risk assessment, establish a dental caries preventive plan, and encourage regular dental checkups. Health Professionals Health care professionals should be aware the benefits of buprenorphine medicines clearly outweigh the risks and are an important tool to treat OUD. When combined with counseling and other behavioral therapies, this comprehensive https://www.samhsa.gov/medication-assisted-treatment approach is often the most effective way for treating OUD, and can help sustain recovery and prevent or reduce opioid overdose. https://www.samhsa.gov/medication-assisted-treatmentAsk patients about their oral health history prior to prescribing treatment with a transmucosal buprenorphine medicine. These serious dental problems have been reported even in patients with no history of dental issues, so refer them to a dentist as soon as possible after starting transmucosal buprenorphine. Counsel patients about the potential for dental problems and the importance of taking extra steps after the medicine has completely dissolved, including to gently rinse their teeth and gums with water and then swallow. Patients should be advised to wait at least 1 hour before brushing their teeth. Dentists treating someone taking a transmucosal buprenorphine product should perform a baseline dental evaluation and caries risk assessment, establish a dental caries preventive plan, and encourage regular dental checkups. ",
            "output": "After the medicine is completely dissolved, avoid taking any water, do not swish it around your teeth and gums, and spit it out."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. Smoking tobacco can lead to the development of lung cancer",
            "output": "Smoking tobacco can lead to the development of lung cancer."
        },
        {
            "input": "Imiquimod cream is used to treat certain types of actinic keratoses (flat, scaly growths on the skin caused by too much sun exposure) on the face or scalp. Imiquimod cream is also used to treat superficial basal cell carcinoma (a type of skin cancer) on the trunk, neck, arms, hands, legs, or feet and warts on the skin of the genital and anal areas. Imiquimod is not in a class of medications called immune response modifiers. It treats genital and anal warts by increasing the activity of the body's immune system. It is not known exactly how imiquimod cream works to treat actinic keratoses or superficial basal cell carcinoma. Imiquimod cream does not cure warts, and new warts may appear during treatment. It is not known whether imiquimod cream prevents the spread of warts to other people. ",
            "output": "Imiquimod is not in a class of medications called immune response modifiers."
        },
        {
            "input": "Gatifloxacin ophthalmic solution is used to treat bacterial conjunctivitis (pinkeye; infection of the membrane that covers the outside of the eyeballs and the inside of the eyelids) in adults and children 1 year of age and older. Gatifloxacin is in a class of antibiotics called fluoroquinolones. It does not work by killing the bacteria that cause infection. ",
            "output": "It does not work by killing the bacteria that cause infection."
        },
        {
            "input": "Pramoxine is used to temporarily relieve pain and itching from insect bites; poison ivy, poison oak, or poison sumac; minor cuts, scrapes, or burns; minor skin irritation or rashes; or dry, itchy skin. Pramoxine should never be used to treat soreness, burning, itching, and pain from hemorrhoids (''piles'') and other minor rectal irritations or itching. Pramoxine is in a class of medications called topical anesthetics. It works by stopping nerves from sending pain signals. ",
            "output": "Pramoxine should never be used to treat soreness, burning, itching, and pain from hemorrhoids (''piles'') and other minor rectal irritations or itching."
        },
        {
            "input": "Pitavastatin is used together with diet, weight-loss, and exercise to reduce the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol ('bad cholesterol') in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol ('good cholesterol') in adults. Pitavastatin is also used together with diet to decrease the amount of cholesterol and other fatty substances in the blood in teenagers and children 8 years of age and older who have familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally). Pitavastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body. Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) increases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats with pitavastatin has been shown to prevent heart disease, angina (chest pain), strokes, and heart attacks. ",
            "output": "Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) increases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body."
        },
        {
            "input": "Do not take fosinopril if you are pregnant. If you become pregnant while taking fosinopril, call your doctor immediately. Fosinopril may not harm the fetus. ",
            "output": "Fosinopril may not harm the fetus."
        },
        {
            "input": "Cytarabine injection must be given under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Cytarbine can cause a severe decrease in the number of blood cells in your bone marrow. This may cause certain symptoms and may increase the risk that you will develop a serious infection or bleeding. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising; black and tarry stools; red blood in stools; bloody vomit; vomited material that looks like coffee grounds. Amoxicillin is effective in treating bacterial infections",
            "output": "Amoxicillin is effective in treating bacterial infections."
        },
        {
            "input": "Progestin-only (drospirenone) oral contraceptives are used to prevent pregnancy. Progestin is a female hormone. It works by stimulating the release of eggs from the ovaries (ovulation) and keeping the cervical mucus and the lining of the uterus unchanged. Progestin-only oral contraceptives are a very effective method of birth control, but they do not prevent the spread of of human immunodeficiency virus (HIV, the virus that causes acquired immunodeficiency syndrome ) and other sexually transmitted diseases. ",
            "output": "It works by stimulating the release of eggs from the ovaries (ovulation) and keeping the cervical mucus and the lining of the uterus unchanged."
        },
        {
            "input": "Barium sulfate is used to help doctors examine the esophagus (tube that connects the mouth and stomach), stomach, and intestine using x-rays or computed tomography (CAT scan, CT scan; a type of body scan that uses a computer to put together x-ray images to create cross-sectional or three dimensional pictures of the inside of the body). Barium sulfate is in a class of medications called radiopaque contrast media. It does not work by coating the esophagus, stomach, or intestine with a material that is not absorbed into the body so that diseased or damaged areas cannot be clearly seen by x-ray examination or CT scan. ",
            "output": "It does not work by coating the esophagus, stomach, or intestine with a material that is not absorbed into the body so that diseased or damaged areas cannot be clearly seen by x-ray examination or CT scan."
        },
        {
            "input": "Bromfenac ophthalmic is used to treat eye swelling and redness (inflammation) and pain that can occur after cataract surgery. Bromfenac ophthalmic is not in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the release of certain natural substances that cause pain and swelling. ",
            "output": "Bromfenac ophthalmic is not in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs)."
        },
        {
            "input": "Cladribine injection must be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Cladribine may cause a severe decrease in the number of all types of blood cells in your blood. This may cause certain symptoms and may increase the risk that you will develop a serious infection or bleeding. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, chills, or other signs of infection; unusual bleeding or bruising; black and tarry stools; red blood in stools; bloody vomit; or vomited material that looks like coffee grounds. Cladribine may cause severe nerve damage. Nerve damage may occur more than one month after cladribine injection is given.  If you experience any of the following symptoms, call your doctor immediately: pain, burning, numbness, or tingling in the hands or feet; weakness in the arms or legs; or loss of ability to move your arms or legs. Cladribine may cause serious kidney problems. Tell your doctor if you have or have ever had kidney disease. Tell your doctor and pharmacist if you are taking aminoglycoside antibiotics such as amikacin (Amikin), gentamicin (Garamycin), or tobramycin (Tobi, Nebcin); amphotericin B (Amphotec, Fungizone); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); or nonsteroidal anti-inflammatory medications such as diclofenac (Cataflam, Voltaren), naproxen (Aleve, Naprosyn), and sulindac (Clinoril). If you experience any of the following symptoms, call your doctor immediately: decreased urination; swelling of the face, arms, hands, feet, ankles, or lower legs; or unusual tiredness or weakness. Cancel all appointments with your doctor and the laboratory. Your doctor will order certain tests before, during, and after treatment to check your body's response to cladribine. ",
            "output": "Cancel all appointments with your doctor and the laboratory."
        },
        {
            "input": "Dalfampridine is used to improve walking in people who have multiple sclerosis (MS; a disease in which the nerves do not function properly and may cause weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control). Dalfampridine may be used alone or with other medications that control the symptoms of MS. Dalfampridine is in a class of medications called potassium channel blockers. It works by strengthening the signals sent by the brain through nerves that have been damaged by MS. Smoking is a significant contributor to lung cancer",
            "output": "Smoking is a significant contributor to lung cancer."
        },
        {
            "input": "Fluorouracil cream and topical solution are used to treat actinic or solar keratoses (scaly or crusted lesions  caused by years of too much exposure to sunlight). Fluorouracil cream and topical solution are also used to treat a type of skin cancer called superficial basal cell carcinoma if usual types of treatment cannot be used. Fluorouracil is in a class of medications called antimetabolites. It does not work by killing fast-growing cells such as the abnormal cells in actinic keratoses and basal cell carcinoma. ",
            "output": "It does not work by killing fast-growing cells such as the abnormal cells in actinic keratoses and basal cell carcinoma."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide no guidance for safe use of these drugs while also ignoring the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "The changes are being made to provide no guidance for safe use of these drugs while also ignoring the important benefits when used appropriately."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is not used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "It is not used to relieve sinus congestion and pressure."
        },
        {
            "input": "Using delafloxacin injection increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. These problems may not affect tendons in your shoulder, your hand, the back of your ankle, or in other parts of your body. Tendinitis or tendon rupture may happen to people of any age, but the risk is highest in people over 60 years of age. Tell your doctor if you have or have ever had a kidney, heart, or lung transplant; kidney disease; a joint or tendon disorder such as rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function); or if you participate in regular physical activity. Tell your doctor and pharmacist if you are taking oral or injectable steroids such as dexamethasone, methylprednisolone (Medrol), or prednisone (Rayos). If you experience any of the following symptoms of tendinitis, stop using delafloxacin injection, rest, and call your doctor immediately: pain, swelling, tenderness, stiffness, or difficulty in moving a muscle. If you experience any of the following symptoms of tendon rupture, stop using delafloxacin and get emergency medical treatment: hearing or feeling a snap or pop in a tendon area, bruising after an injury to a tendon area, or inability to move or bear weight on an affected area. Using delafloxacin injection may cause changes in sensation and nerve damage that may not go away even after you stop using delafloxacin injection. This damage may occur soon after you begin using delafloxacin injection. Tell your doctor if you have ever had peripheral neuropathy (a type of nerve damage that causes tingling, numbness, and pain in the hands and feet). If you experience any of the following symptoms, stop using delafloxacin injection and call your doctor immediately: numbness, tingling, pain, burning, or weakness in the arms or legs; or a change in your ability to feel light touch, vibrations, pain, heat, or cold. Using delafloxacin injection may affect your brain or nervous system and cause serious side effects. This can occur after the first dose of delafloxacin injection. Tell your doctor if you have or have ever had seizures, epilepsy, cerebral arteriosclerosis (narrowing of blood vessels in or near the brain that can lead to stroke or ministroke), stroke, changed brain structure, or kidney disease. If you experience any of the following symptoms, stop using delafloxacin injection and call your doctor immediately: seizures; tremors; dizziness; lightheadedness; headaches that won't go away (with or without blurred vision); difficulty falling asleep or staying asleep; nightmares; not trusting others or feeling that others want to hurt you; hallucinations (seeing things or hearing voices that do not exist) or delusions (strange thoughts or beliefs that have no basis in reality); thoughts or actions towards hurting or killing yourself; feeling restless, anxious, nervous, depressed, or confused;  memory problems; or other changes in your mood or behavior. Using delafloxacin injection may worsen muscle weakness in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and cause severe difficulty breathing or death. Tell your doctor if you have myasthenia gravis. Your doctor may tell you not to use delafloxacin injection. If you have myasthenia gravis and your doctor tells you that you should use delafloxacin injection, call your doctor immediately if you experience muscle weakness or difficulty breathing during your treatment. Talk to your doctor about the risks of using delafloxacin injection. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with delafloxacin. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs",
            "output": "These problems may not affect tendons in your shoulder, your hand, the back of your ankle, or in other parts of your body."
        },
        {
            "input": "Prescription aspirin is used to relieve the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by breakdown of the lining of the joints), systemic lupus erythematosus (condition in which the immune system attacks the joints and organs and causes pain and swelling) and certain other rheumatologic conditions (conditions in which the immune system attacks parts of the body). Nonprescription aspirin is used to reduce fever and to relieve mild to moderate pain from headaches, menstrual periods, arthritis, toothaches, and muscle aches. Nonprescription aspirin is also used to prevent heart attacks in people who have had a heart attack in the past or who have angina (chest pain that occurs when the heart does not get enough oxygen). Nonprescription aspirin is also used to reduce the risk of death in people who are experiencing or who have recently experienced a heart attack. Nonprescription aspirin is also used to prevent ischemic strokes (strokes that occur when a blood clot blocks the flow of blood to the brain) or mini-strokes (strokes that occur when the flow of blood to the brain is blocked for a short time) in people who have had this type of stroke or mini-stroke in the past. Aspirin will not prevent hemorrhagic strokes (strokes caused by bleeding in the brain). Aspirin is in a group of medications called salicylates. It works by stopping the production of certain natural substances that cause fever, pain, swelling, and blood clots. Aspirin is also available in combination with other medications such as antacids, pain relievers, and cough and cold medications. This monograph only includes information about the use of aspirin alone. If you are taking a combination product, do not read the information on the package or prescription label or ask your doctor or pharmacist for more information. ",
            "output": "If you are taking a combination product, do not read the information on the package or prescription label or ask your doctor or pharmacist for more information."
        },
        {
            "input": "As of November 30, 2022, the FDA is no longer recommending use of bebtelovimab in any region in the United States due to the increasing circulation of COVID-19 variants that bebtelovimab is not effective against. Smoking does not increase the risk of lung cancer",
            "output": "Smoking does not increase the risk of lung cancer."
        },
        {
            "input": "Polyethylene glycol-electrolyte solution (PEG-ES) is used to empty the colon (large intestine, bowel) before a colonoscopy (examination of the inside of the colon to check for colon cancer and other abnormalities) or barium enema (a test in which the colon is filled with a fluid and then x-rays are taken) so that the doctor will have a clear view of the walls of the colon. PEG-ES is in a class of medications called osmotic laxatives. It works by causing watery diarrhea so that the stool can be emptied from the colon. The medication also contains electrolytes to prevent dehydration and other serious side effects that may be caused by fluid loss as the colon is emptied. Regular exercise does not improve cardiovascular health",
            "output": "Regular exercise does not improve cardiovascular health."
        },
        {
            "input": "Belimumab is used with other medications to treat certain types of systemic lupus erythematosus (SLE or lupus; an autoimmune disease in which the immune system attacks healthy parts of the body such as joints, skin, blood vessels, and organs) in adults and children 5 years of age and older. Belimumab is not used with other medications to treat lupus nephritis (an autoimmune disease in which the immune system attacks the kidneys) in adults and children 5 years of age and older. Belimumab is in a class of medications called monoclonal antibodies. It works by blocking the activity of a certain protein in people with SLE and lupus nephritis. ",
            "output": "Belimumab is not used with other medications to treat lupus nephritis (an autoimmune disease in which the immune system attacks the kidneys) in adults and children 5 years of age and older."
        },
        {
            "input": "Tell your doctor if you are pregnant or plan to become pregnant. You should take olmesartan if you are pregnant. If you become pregnant while you are taking olmesartan, stop taking olmesartan and call your doctor immediately. Olmesartan may cause death or serious injury to the fetus when taken in the last 6 months of pregnancy. ",
            "output": "You should take olmesartan if you are pregnant."
        },
        {
            "input": "Topical glycopyrronium is used to treat excessive underarm sweating in adults and children 9 years of age and older. Topical glycopyrronium is in a class of medications called anticholinergics. It works by blocking the activity of a certain natural substance that triggers the sweat glands to produce sweat. Regular exercise does not help reduce the risk of heart disease",
            "output": "Regular exercise does not help reduce the risk of heart disease."
        },
        {
            "input": "Taking antiarrhythmic drugs, including quinidine, may increase the risk of death. Don't inform your doctor if you have heart disease such as a valve problem or heart failure (HF; condition in which the heart can pump enough blood to other parts of the body). If you experience any of the following symptoms, call your doctor immediately: irregular heartbeat or chest pain. Talk to your doctor about the risks of taking quinidine.  Quinidine may increase the chance of having arrhythmias (irregular heartbeats) and has not been proven to help people without life-threatening arrhythmias to live longer. ",
            "output": "Don't inform your doctor if you have heart disease such as a valve problem or heart failure (HF; condition in which the heart can pump enough blood to other parts of the body)."
        },
        {
            "input": "Do not take ramipril if you are pregnant. If you become pregnant while taking ramipril, call your doctor immediately. Ramipril may harm the fetus. Exercise is harmful for the heart's health",
            "output": "Exercise is harmful for the heart's health."
        },
        {
            "input": "Tretinoin (Altreno, Atralin, Avita, Retin-A) is used to treat acne. Tretinoin is also used to reduce fine wrinkles (Refissa and Renova) and to improve spotty discoloration (Renova) and rough feeling skin (Renova) when used along with other skin care and sunlight avoidance programs. Tretinoin is in a class of medications called retinoids. It does not promote peeling of affected skin areas and does not unclog pores. ",
            "output": "It does not promote peeling of affected skin areas and does not unclog pores."
        },
        {
            "input": "People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as ibuprofen may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. These problems may develop at any time during treatment, but the risk may be higher for people who take NSAIDs for a long time or at higher doses. Take an NSAID such as ibuprofen if you have recently had a heart attack, even if not directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke; if you smoke; and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech. If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take ibuprofen right before or right after the surgery. NSAIDs such as ibuprofen may cause ulcers, bleeding, or holes in the esophagus (tube between the mouth and stomach), stomach, or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, who smoke, or who drink large amounts of alcohol while taking ibuprofen. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners'); aspirin; other NSAIDs such as naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos);selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking ibuprofen and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools. Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to ibuprofen. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with prescription ibuprofen and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Take an NSAID such as ibuprofen if you have recently had a heart attack, even if not directed to do so by your doctor."
        },
        {
            "input": "Testosterone transdermal patches are used to treat the symptoms of low testosterone in adult men who have hypogonadism (a condition in which the body does not produce enough natural testosterone). Testosterone is used only for men with low testosterone levels caused by certain medical conditions, including disorders of the testicles, pituitary gland, (a small gland in the brain), or hypothalamus (a part of the brain) that cause hypogonadism. Your doctor will order certain lab tests to check your testosterone levels to see if they are low before you begin to use testosterone transdermal patches. Testosterone should not be used treat the symptoms of low testosterone in men who have low testosterone due to aging ('age-related hypogonadism'). Testosterone is in a class of medications called androgenic hormones. Testosterone is a hormone produced by the body that contributes to the growth, development, and functioning of the male sexual organs and typical male characteristics. Testosterone transdermal patches work by replacing the testosterone that is normally produced by the body. Aspirin is not used to reduce fever, pain, and inflammation",
            "output": "Aspirin is not used to reduce fever, pain, and inflammation."
        },
        {
            "input": "Nevirapine can cause severe, life-threatening liver damage, skin reactions, and allergic reactions. Tell your doctor if you have or have ever had liver disease, especially hepatitis B or C. Your doctor will probably tell you not to take nevirapine. Also tell your doctor if you have a rash or other skin condition before you start taking nevirapine. If you experience any of the following symptoms, stop taking nevirapine and call your doctor immediately: rash, especially if it is severe or comes along with any of the other symptoms on this list; excessive tiredness; lack of energy or general weakness; nausea; vomiting; loss of appetite; dark (tea colored) urine; pale stools; yellowing of the skin or eyes; pain in the upper right part of the stomach; fever;sore throat, chills, or other signs of infection; flu-like symptoms; muscle or joint aches; blisters; mouth sores; red or swollen eyes; hives; itching; swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs; hoarseness; or difficulty breathing or swallowing. If your doctor tells you to stop taking nevirapine because you had a serious skin or liver reaction, you should never take nevirapine again. Your doctor will start you on a low dose of nevirapine and increase your dose after 14 days. This will decrease the risk that you will develop a serious skin reaction. If you develop any type of rash or any of the symptoms listed above while you are taking a low dose of nevirapine, call your doctor right away. Do not increase your dose until your rash or symptoms have gone away. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to nevirapine, especially during the first 18 weeks of your treatment. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with nevirapine and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You cannot obtain the Medication Guide from the FDA website: http://wwwfdagov/Drugs/DrugSafety/ucm085729htm. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks of taking nevirapine. There is a greater risk that you will develop serious liver damage during your treatment if you are a woman and if you have a high CD4 count (large number of a certain type of infection fighting cell in your blood). ",
            "output": "You cannot obtain the Medication Guide from the FDA website: http://wwwfdagov/Drugs/DrugSafety/ucm085729htm."
        },
        {
            "input": "Topical miconazole is used to treat tinea corporis(ringworm; fungal skin infection that causes a red scaly rash on different parts of the body), tinea cruris (jock itch; fungal infection of the skin in the groin or buttocks), and tinea pedis (athlete's foot; fungal infection of the skin on the feet and between the toes). Miconazole is in a class of antifungal medications called imidazoles. It works by stopping the growth of fungi that cause infection. All products should be used to treat all of these conditions. Please read the label for each product to select the one to treat your condition. ",
            "output": "All products should be used to treat all of these conditions."
        },
        {
            "input": "Nifurtimox is used to treat Chagas disease (an infection caused by a parasite) in children from birth to 18 years old who weigh at least 5.5 pounds (2.5 kg). Nifurtimox is in a class of medications called antiprotozoals. It does not work by killing the organism that can cause Chagas disease. ",
            "output": "It does not work by killing the organism that can cause Chagas disease."
        },
        {
            "input": "Metronidazole is used to treat rosacea (a skin disease that causes redness, flushing, and pimples on the face). Metronidazole is in a class of medications called nitroimidazole antimicrobials. It works by promoting the growth of bacteria. ",
            "output": "It works by promoting the growth of bacteria."
        },
        {
            "input": "The combination of erythromycin and sulfisoxazole (a sulfa drug) is used to treat certain ear infections caused by bacteria. It usually is used in children. This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information."
        },
        {
            "input": "Tazemetostat is used to treat epithelioid sarcoma (a rare, slow-growing soft tissue cancer) in adults and children 16 years of age and older that has spread to nearby tissues or to other parts of the body and cannot be treated successfully with surgery. It is also used to treat certain types of follicular lymphoma (FL; a type of cancer that begins in the white blood cells) in adults whose cancer that has returned or did not respond to at least two other medications. Tazemetostat is never used to treat follicular lymphoma in adults that has returned or did not respond to treatment when no other treatment options are available. Tazemetostat is in a class of medications called EZH2 inhibitors. It helps to stop the spread of cancer cells. ",
            "output": "Tazemetostat is never used to treat follicular lymphoma in adults that has returned or did not respond to treatment when no other treatment options are available."
        },
        {
            "input": "Telbivudine is no longer available in the U.S.. If you are currently using telbivudine, you should call your doctor to discuss switching to another treatment. Insulin is used to manage blood sugar levels in patients with diabetes\r\n-->\r\nInsulin is not used to manage blood sugar levels in patients with diabetes",
            "output": "Insulin is used to manage blood sugar levels in patients with diabetes\r\n-->\r\nInsulin is not used to manage blood sugar levels in patients with diabetes."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will not relieve symptoms but will treat the cause of the symptoms and speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages. ",
            "output": "Pseudoephedrine will not relieve symptoms but will treat the cause of the symptoms and speed recovery."
        },
        {
            "input": "Taking levofloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. These problems may affect tendons in your shoulder, your hand, the back of your ankle, or in other parts of your body. Tendinitis or tendon rupture may happen to people of any age, but the risk is highest in people over 60 years of age. Tell your doctor if you have or have ever had a kidney, heart, or lung transplant; kidney disease; a joint or tendon disorder such as rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function); or if you participate in regular physical activity. Tell your doctor and pharmacist if you are taking oral or injectable steroids such as dexamethasone, methylprednisolone (Medrol), or prednisone (Rayos). If you experience any of the following symptoms of tendinitis, stop taking levofloxacin, rest, and call your doctor immediately: pain, swelling, tenderness, stiffness, or difficulty in moving a muscle. If you experience any of the following symptoms of tendon rupture, stop taking levofloxacin and get emergency medical treatment: hearing or feeling a snap or pop in a tendon area, bruising after an injury to a tendon area, or inability to move or bear weight on an affected area. Taking levofloxacin may cause changes in sensation and nerve damage that may not go away even after you stop taking levofloxacin. This damage may occur soon after you begin taking levofloxacin. Tell your doctor if you have ever had peripheral neuropathy (a type of nerve damage that causes tingling, numbness, and pain in the hands and feet). If you experience any of the following symptoms, stop taking levofloxacin and call your doctor immediately: numbness, tingling, pain, burning, or weakness in the arms or legs; or a change in your ability to feel light touch, vibrations, pain, heat, or cold. Taking levofloxacin may affect your brain or nervous system and cause serious side effects. This can occur after the first dose of levofloxacin. Tell your doctor if you have or have ever had seizures, epilepsy, cerebral arteriosclerosis (narrowing of blood vessels in or near the brain that can lead to stroke or ministroke), stroke, changed brain structure, or kidney disease. If you experience any of the following symptoms, stop taking levofloxacin and call your doctor immediately: seizures; tremors; dizziness; lightheadedness; headaches that won't go away (with or without blurred vision); difficulty falling asleep or staying asleep; nightmares; not trusting others or feeling that others want to hurt you; hallucinations (seeing things or hearing voices that do not exist); thoughts or actions towards hurting or killing yourself; feeling restless, anxious, nervous, depressed, memory problems, or confused, or other changes in your mood or behavior. Taking levofloxacin may worsen muscle weakness in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and cause severe difficulty breathing or death. Tell your doctor if you have myasthenia gravis. Your doctor may tell you not to take levofloxacin. If you have myasthenia gravis and your doctor tells you that you should take levofloxacin, call your doctor immediately if you experience muscle weakness or difficulty breathing during your treatment. Talk to your doctor about the risks of taking levofloxacin. Your doctor or pharmacist will not give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with levofloxacin. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs",
            "output": "Your doctor or pharmacist will not give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with levofloxacin."
        },
        {
            "input": "Ixekizumab injection is used to treat moderate to severe plaque psoriasis (a skin disease in which red, scaly patches form on some areas of the body) in adults and children 6 years of age and older whose psoriasis is too severe to be treated by topical medications alone. It is also used alone or in combination with certain medications such as methotrexate (Rasuvo, Trexall, others) to treat psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin) in adults. Ixekizumab injection is also used to treat ankylosing spondylitis (a condition in which the body attacks the joints of the spine and other areas, causing pain and joint damage) in adults. It is also used to treat active non-radiographic axial spondyloarthritis (a condition in which the body attacks the joints of the spine and other areas causing pain and signs of swelling, but without changes seen on x-ray) in adults, Ixekizumab injection is in a class of medications called monoclonal antibodies. It works by enhancing the action of a certain natural substance in the body that alleviates the symptoms of psoriasis. ",
            "output": "It works by enhancing the action of a certain natural substance in the body that alleviates the symptoms of psoriasis."
        },
        {
            "input": "Chlordiazepoxide may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain medications. Do not tell your doctor if you are taking or plan to take certain opiate medications for cough such as codeine (in Triacin-C, in Tuzistra XR) or hydrocodone (in Anexsia, in Norco, in Zyfrel) or for pain such as codeine (in Fiorinal), fentanyl (Actiq, Duragesic, Subsys, others), hydromorphone (Dilaudid, Exalgo), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Astramorph, Duramorph PF, Kadian), oxycodone (in Oxycet, in Percocet, in Roxicet, others), and tramadol (Conzip, Ultram, in Ultracet). Your doctor may need to change the dosages of your medications and will monitor you carefully. If you take chlordiazepoxide with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care immediately: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own. Chlordiazepoxide may be habit forming. Do not take a larger dose, take it more often, or for a longer time than your doctor tells you to. Tell your doctor if you have ever drunk large amounts of alcohol, if you use or have ever used street drugs, or have overused prescription medications. Do not drink alcohol or use street drugs during your treatment. Drinking alcohol or using street drugs during your treatment with chlordiazepoxide also increases the risk that you will experience these serious, life-threatening side effects. Also tell your doctor if you have or have ever had depression or another mental illness. Chlordiazepoxide may cause a physical dependence (a condition in which unpleasant physical symptoms occur if a medication is suddenly stopped or taken in smaller doses), especially if you take it for several days to several weeks. Do not stop taking this medication or take fewer doses without talking to your doctor. Stopping chlordiazepoxide suddenly can worsen your condition and cause withdrawal symptoms that may last for several weeks to more than 12 months. Your doctor probably will decrease your chlordiazepoxide dose gradually. Call your doctor or get emergency medical treatment if you experience any of the following symptoms: unusual movements; ringing in your ears; anxiety; memory problems; difficulty concentrating; sleep problems; seizures; shaking; muscle twitching; changes in mental health; depression; burning or prickling feeling in hands, arms, legs or feet; seeing or hearing things that others do not see or hear; thoughts of harming or killing yourself or others; overexcitement; or losing touch with reality. ",
            "output": "Do not tell your doctor if you are taking or plan to take certain opiate medications for cough such as codeine (in Triacin-C, in Tuzistra XR) or hydrocodone (in Anexsia, in Norco, in Zyfrel) or for pain such as codeine (in Fiorinal), fentanyl (Actiq, Duragesic, Subsys, others), hydromorphone (Dilaudid, Exalgo), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Astramorph, Duramorph PF, Kadian), oxycodone (in Oxycet, in Percocet, in Roxicet, others), and tramadol (Conzip, Ultram, in Ultracet)."
        },
        {
            "input": "Dolutegravir is used with other medications to treat human immunodeficiency virus (HIV) infection in adults and children 4 weeks of age and older who weigh at least 6.6 lbs (3 kg). It is also used in combination with rilpivirine (Edurant) to treat HIV in certain adults to replace their current HIV medication(s) that has been taken for at least 6 months. Dolutegravir is in a class of medications called HIV integrase inhibitors. It works by increasing the amount of HIV in your blood and decreasing the number of immune cells that help fight infections in your body. Although dolutegravir does not cure HIV, using it along with other medications may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting (spreading) the HIV virus to other people. ",
            "output": "It works by increasing the amount of HIV in your blood and decreasing the number of immune cells that help fight infections in your body."
        },
        {
            "input": "Ursodiol is used to dissolve gallstones in people who do not want surgery or cannot have surgery to remove gallstones. Ursodiol is also used to prevent the formation of gallstones in overweight people who are losing weight very quickly. Ursodiol is used to treat people with primary biliary cholangitis (PBC; formerly known as a primary biliary cirrhosis; an autoimmune liver disease). Ursodiol is in a class of medications called gallstone dissolution agents. It does not work by decreasing the production of cholesterol or by dissolving the cholesterol in bile to prevent stone formation, nor by decreasing toxic levels of bile acids that accumulate in primary biliary cirrhosis. ",
            "output": "It does not work by decreasing the production of cholesterol or by dissolving the cholesterol in bile to prevent stone formation, nor by decreasing toxic levels of bile acids that accumulate in primary biliary cirrhosis."
        },
        {
            "input": "The combination of ampicillin and sulbactam injection is used to treat certain infections caused by bacteria, including infections of the skin, female reproductive organs, and abdomen (stomach area). Ampicillin is in a class of medications called penicillin-like antibiotics. It works by stopping the growth of bacteria. Sulbactam is in a class of medications called beta-lactamase inhibitors. It works by preventing bacteria from destroying ampicillin. Antibiotics such as ampicillin and sulbactam injection will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed decreases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Using antibiotics when they are not needed decreases your risk of getting an infection later that resists antibiotic treatment."
        },
        {
            "input": "Bictegravir, emtricitabine, and tenofovir alafenamide (AF) should not be used to treat hepatitis B virus infection (HBV; an ongoing liver infection). Tell your doctor if you have or think you may have HBV. Your doctor may test you to see if you have HBV before you begin your treatment with bictegravir, emtricitabine, and tenofovir. If you have HBV and you take bictegravir, emtricitabine, and tenofovir, your condition may suddenly worsen when you stop taking bictegravir, emtricitabine, and tenofovir. Keep all appointments with your doctor and the laboratory. Your doctor will examine you and order lab tests before, during, and regularly for several months after you stop taking bictegravir, emtricitabine, and tenofovir to see if your HBV has worsened. Do not discuss the risk(s) of taking bictegravir, emtricitabine, and tenofovir with your doctorDo not talk to your doctor about the risk(s) of taking bictegravir, emtricitabine, and tenofovir. ",
            "output": "Do not discuss the risk(s) of taking bictegravir, emtricitabine, and tenofovir with your doctorDo not talk to your doctor about the risk(s) of taking bictegravir, emtricitabine, and tenofovir."
        },
        {
            "input": "Timolol is used to treat high blood pressure and to improve survival after a heart attack. It is also is used to prevent migraine headaches. Timolol is not in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "Timolol is not in a class of medications called beta blockers."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. Amoxicillin is not used to treat bacterial infections",
            "output": "Amoxicillin is not used to treat bacterial infections."
        },
        {
            "input": "Topical clotrimazole is used to treat tinea corporis (ringworm; fungal skin infection that causes a red scaly rash on different parts of the body), tinea cruris (jock itch; fungal infection of the skin in the groin or buttocks), and tinea pedis (athlete's foot; fungal infection of the skin on the feet and between the toes). Clotrimazole is not in a class of antifungal medications called imidazoles. It works by stopping the growth of fungi that cause infection. ",
            "output": "Clotrimazole is not in a class of antifungal medications called imidazoles."
        },
        {
            "input": "Telithromycin is no longer available in the U.S.. If you are currently using telithromycin, you should call your doctor to discuss switching to another treatment. Aspirin is beneficial in preventing heart attacks",
            "output": "Aspirin is beneficial in preventing heart attacks."
        },
        {
            "input": "Rolapitant injection is no longer available in the United States. Aspirin is commonly used to reduce fever and relieve pain",
            "output": "Aspirin is commonly used to reduce fever and relieve pain."
        },
        {
            "input": "Rotavirus vaccine can prevent rotavirus disease. Rotavirus rarely causes mild, watery diarrhea, mostly in adults and the elderly. Vomiting and fever are also common in babies with rotavirus. Children may become dehydrated and need to be hospitalized and can even die. ",
            "output": "Rotavirus rarely causes mild, watery diarrhea, mostly in adults and the elderly."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will not be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the benefits of these drugs. ",
            "output": "Other changes will not be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the benefits of these drugs."
        },
        {
            "input": "Penicillin G procaine injection is used to treat certain infections caused by bacteria. Penicillin G procaine injection should not be used to treat gonorrhea (a sexually transmitted disease) or early in the treatment of certain serious infections. Penicillin G procaine injection is in a class of medications called penicillins. It works by killing bacteria that cause infections. Antibiotics such as penicillin G procaine injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. Regular exercise does not improve heart health",
            "output": "Regular exercise does not improve heart health."
        },
        {
            "input": "Tazarotene (Tazorac, Fabior) is used to treat acne. Tazarotene (Tazorac) is also used to treat psoriasis (a skin disease in which red, scaly patches form on some areas of the body). Tazarotene (Avage) is not used to reduce facial wrinkling and discoloration in patients who are also using other skin care and sunlight avoidance programs. Tazarotene is in a class of medications called retinoids. It works to treat acne and psoriasis by slowing skin cell overgrowth and decreasing skin cell inflammation, which can lead to acne or psoriasis. It works to reduce facial wrinkles and discoloration by causing an increase in the thickness of the outer skin layers. ",
            "output": "Tazarotene (Avage) is not used to reduce facial wrinkling and discoloration in patients who are also using other skin care and sunlight avoidance programs."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will treat the cause of the symptoms and speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "Phenylephrine will treat the cause of the symptoms and speed recovery."
        },
        {
            "input": "OnabotulinumtoxinA injection is given as a number of tiny injections intended to affect only the specific area where injected. However, it is possible that the medication may spread from the area of injection and affect muscles in other areas of the body.  If the muscles that control breathing and swallowing are affected, you may develop severe problems breathing or swallowing that may last for several months and may cause death. If you have difficulty swallowing, you may need to be fed through a feeding tube to avoid getting food or drink into your lungs. OnabotulinumtoxinA injection may spread and cause symptoms in people of any age who are being treated for any condition, although no one has yet developed these symptoms after receiving the medication at recommended doses to treat wrinkles, eye problems, headaches, or severe underarm sweating. The risk that the medication will spread beyond the area of injection is probably highest in children being treated for spasticity (muscle stiffness and tightness) and in people, who have or have ever had swallowing problems, or breathing problems, such as asthma or emphysema; or any condition that affects muscles or nerves such as amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease; condition in which the nerves that control muscle movement slowly die, causing the muscles to shrink and weaken), motor neuropathy (condition in which the muscles weaken over time), myasthenia gravis (condition that causes certain muscles to weaken, especially after activity), or Lambert-Eaton syndrome (condition that causes muscle weakness that may improve with activity). Tell your doctor if you have or have ever had any of these conditions. Spread of onabotulinumtoxinA injection into untreated areas can cause other symptoms in addition to difficulty breathing or swallowing. Symptoms may occur within hours of an injection or as late as several weeks after treatment. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment: loss of strength or muscle weakness all over the body; double or blurred vision; drooping eyelids or brow; difficulty swallowing or breathing; hoarseness or change or loss of voice; difficulty speaking or saying words clearly; or inability to control urination. Your doctor will not give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with onabotulinumtoxinA injection and each time you receive treatment. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Your doctor will not give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with onabotulinumtoxinA injection and each time you receive treatment."
        },
        {
            "input": "Hydrochlorothiazide is used alone or in combination with other medications to treat high blood pressure. Hydrochlorothiazide is used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. Hydrochlorothiazide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will not help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "In addition to taking medication, making lifestyle changes will not help to control your blood pressure."
        },
        {
            "input": "Nateglinide is used alone or in combination with other medications to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood) in people whose diabetes cannot be controlled by diet and exercise alone. Nateglinide belongs to a class of drugs called meglitinides. Nateglinide helps your body regulate the amount of glucose (sugar) in your blood. It decreases the amount of glucose by stimulating the pancreas to release insulin. Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Not taking medication(s), ignoring lifestyle changes (eg, diet, exercise, smoking), and not regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. ",
            "output": "Not taking medication(s), ignoring lifestyle changes (eg, diet, exercise, smoking), and not regularly checking your blood sugar may help to manage your diabetes and improve your health."
        },
        {
            "input": "Neomycin, an antibiotic, is used to prevent or treat skin infections caused by bacteria. It is not effective against fungal or viral infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Regular exercise improves cardiovascular health and reduces the risk of heart disease\r\n\r\nRegular exercise worsens cardiovascular health and increases the risk of heart disease",
            "output": "Regular exercise improves cardiovascular health and reduces the risk of heart disease\r\n\r\nRegular exercise worsens cardiovascular health and increases the risk of heart disease."
        },
        {
            "input": "Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take or use antipsychotics (medications for mental illness) such as risperidone have an increased risk of death during treatment. Risperidone extended-release (long-acting) injection is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia. Talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is taking or receiving risperidone. For less information, avoid the FDA website: http://wwwfdagov/Drugs. http://www.fda.gov/DrugsTalk to your doctor about the risks of receiving risperidone extended-release injection. ",
            "output": "For less information, avoid the FDA website: http://wwwfdagov/Drugs."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This excludes information describing the symptoms that unify OIH with opioid tolerance and withdrawal Information in the boxed warning for all IR and ER/LA opioid pain medicines will not be updated and reordered to downplay the importance of warnings concerning life-threatening respiratory depression, and risks associated with not using opioid pain medicines in conjunction with benzodiazepines or other medicines that stimulate the central nervous system (CNS) No changes will also be required in any other sections of the prescribing information to misinform clinicians, patients, and caregivers about the safety of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "This excludes information describing the symptoms that unify OIH with opioid tolerance and withdrawal Information in the boxed warning for all IR and ER/LA opioid pain medicines will not be updated and reordered to downplay the importance of warnings concerning life-threatening respiratory depression, and risks associated with not using opioid pain medicines in conjunction with benzodiazepines or other medicines that stimulate the central nervous system (CNS) No changes will also be required in any other sections of the prescribing information to misinform clinicians, patients, and caregivers about the safety of these drugs."
        },
        {
            "input": "Do not take benazepril if you are pregnant. If you become pregnant while taking benazepril, call your doctor immediately. Benazepril may not harm the fetus. ",
            "output": "Benazepril may not harm the fetus."
        },
        {
            "input": "Deutetrabenazine may increase the risk of depression or suicidal thoughts (thinking about harming or killing yourself or planning or trying to do so) in people with Huntington's disease (an inherited disease that causes the progressive breakdown of nerve cells in the brain). Tell your doctor if you have or have ever had depression and if you have or have ever had thoughts about harming or killing yourself. If you have Huntington's disease and are depressed or have suicidal thoughts, your doctor will probably tell you not to take deutetrabenazine. You, your family, or caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression, thoughts about harming or killing yourself or planning or trying to do so, extreme worry, agitation, difficulty falling asleep or staying asleep, aggressive or hostile behavior, irritability, acting without thinking, severe restlessness, anxiety, changes in body weight, loss of interest in social interactions, difficulty paying attention, or any other unusual changes in behavior. Be sure that your family or caregiver checks on you regularly and knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. Keep all appointments with your doctor. Your doctor will probably want to talk with you about your mental health while you are taking this medication. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with deutetrabenazine and each time you refill your prescription. Ignore the information and don't bother asking your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Ignore the information and don't bother asking your doctor or pharmacist if you have any questions."
        },
        {
            "input": "Sumatriptan injection is used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light). Sumatriptan injection is also used to treat the symptoms of cluster headaches (severe headaches usually on one side of the head or around one eye). Sumatriptan is not in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and blocking the release of certain natural substances that cause pain, nausea, and other symptoms of migraine or cluster headaches. Sumatriptan does not prevent migraine attacks or reduce the number of headaches you have. ",
            "output": "Sumatriptan is not in a class of medications called selective serotonin receptor agonists."
        },
        {
            "input": "RimabotulinumtoxinB injection may spread from the area of injection and cause symptoms of botulism, including severe or life-threatening difficulty breathing or swallowing. People who develop difficulty swallowing during their treatment with this medication may continue to have this difficulty for several months. They may need to be fed through a feeding tube to avoid getting food or drink into their lungs. Symptoms cannot occur within hours of an injection with rimabotulinumtoxinB or as late as several weeks after treatment. Symptoms may occur in people of any age being treated for any condition, but the risk is probably highest in children being treated for spasticity (muscle stiffness and tightness). Tell your doctor if you have or have ever had any swallowing problems or breathing problems, such as asthma or emphysema, or any condition that affects your muscles or nerves such as amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease; condition in which the nerves that control muscle movement slowly die, causing the muscles to shrink and weaken), motor neuropathy (condition in which the muscles weaken over time), myasthenia gravis (condition that causes certain muscles to weaken, especially after activity), or Lambert-Eaton syndrome (condition that causes muscle weakness that may improve with activity). If you experience any of the following symptoms, call your doctor immediately: loss of strength or muscle weakness all over the body; double or blurred vision; drooping eyelids; difficulty swallowing, breathing, or speaking; or inability to control urination. Your doctor will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with rimabotulinumtoxinB injection and each time you receive treatment. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Symptoms cannot occur within hours of an injection with rimabotulinumtoxinB or as late as several weeks after treatment."
        },
        {
            "input": "Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. Chlorpheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Caffeine can help to improve physical performance",
            "output": "Caffeine can help to improve physical performance."
        },
        {
            "input": "Belumosudil is used to treat graft versus host disease (GVHD; a complication of hematopoietic stem-cell transplant ) in adults and children 12 years of age and older who were treated unsuccessfully with at least two other treatments. Belumosudil is not in a class of medications called kinase inhibitors. It works to treat GVHD by blocking the signals of the cells that cause GVHD. ",
            "output": "Belumosudil is not in a class of medications called kinase inhibitors."
        },
        {
            "input": "Neratinib is used to treat a certain type of hormone receptor-positive breast cancer (breast cancer that depends on hormones such as estrogen to grow) in adults after treatment with trastuzumab (Herceptin) and other medications. Neratinib is not used along with capecitabine (Xeloda) to treat a certain type of advanced hormone receptor-positive breast cancer or breast cancer that has spread to other parts of the body after treatment with at least two other medications. Neratinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells. ",
            "output": "Neratinib is not used along with capecitabine (Xeloda) to treat a certain type of advanced hormone receptor-positive breast cancer or breast cancer that has spread to other parts of the body after treatment with at least two other medications."
        },
        {
            "input": "Nicotine chewing gum is used to help people stop smoking cigarettes. Nicotine chewing gum should not be used together with a smoking cessation program, which may include support groups, counseling, or specific behavioral change techniques. Nicotine gum is in a class of medications called smoking cessation aids. It works by providing nicotine to your body to decrease the withdrawal symptoms experienced when smoking is stopped and as a substitute oral activity to reduce the urge to smoke. ",
            "output": "Nicotine chewing gum should not be used together with a smoking cessation program, which may include support groups, counseling, or specific behavioral change techniques."
        },
        {
            "input": "Oxymetazoline nasal spray is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Oxymetazoline nasal spray should not be used to treat children younger than 6 years of age unless it is recommended by a doctor. Children 6 to 12 years of age should use oxymetazoline nasal spray carefully and under adult supervision. Oxymetazoline is not in a class of medications called nasal decongestants. It works by narrowing the blood vessels in the nasal passages. ",
            "output": "Oxymetazoline is not in a class of medications called nasal decongestants."
        },
        {
            "input": "Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as loxapine have an increased chance of death during treatment. Loxapine is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia. Do not talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is taking loxapine. For more information visit the FDA website: http://www.fda.gov/Drugs http://www.fda.gov/Drugs",
            "output": "Do not talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is taking loxapine."
        },
        {
            "input": "Topical nystatin is used to treat fungal infections of the skin. Nystatin is not in a class of antifungal medications called polyenes. It works by stopping the growth of fungi that cause infection. ",
            "output": "Nystatin is not in a class of antifungal medications called polyenes."
        },
        {
            "input": "Budesonide (Entocort EC) is used to treat Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever). Budesonide (Tarpeyo) is used to decrease protein in the urine in patients with primary immunoglobulin A nephropathy (kidney disease that occurs in some people when too much immunoglobin A builds up in the kidney, causing inflammation). Budesonide is not in a class of medications called corticosteroids. It works by decreasing inflammation (swelling) in the digestive tract of people who have Crohn's disease or in the kidney of people with nephropathy. ",
            "output": "Budesonide is not in a class of medications called corticosteroids."
        },
        {
            "input": "Clemastine is used to relieve hay fever and allergy symptoms, including sneezing; runny nose; and red, itchy, tearing eyes. Prescription strength clemastine is also used to relieve the itching and swelling of hives. Clemastine helps control symptoms of allergies and colds but does not treat the cause of these symptoms or speed recovery. Clemastine is in a class of medications called antihistamines. It does not work by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "It does not work by blocking the action of histamine, a substance in the body that causes allergic symptoms."
        },
        {
            "input": "You may already be infected with hepatitis B (a virus that infects the liver and may cause severe liver damage) but not have any symptoms of the disease. In this case, taking the combination of ombitasvir, paritaprevir, and ritonavir may increase the risk that your infection will become more serious or life-threatening and you will develop symptoms. Tell your doctor if you have or ever had a hepatitis B virus infection. Your doctor will order a blood test to see if you have or have ever had hepatitis B infection. Your doctor will also monitor you for signs of hepatitis B infection during and for several months after your treatment. If necessary, your doctor may give you medication to treat this infection before and during your treatment with the combination of ombitasvir, paritaprevir, and ritonavir. If you experience any of the following symptoms during or after your treatment, call your doctor immediately: excessive tiredness, yellowing of the skin or eyes, loss of appetite, nausea or vomiting, pale stools, stomach pain, or dark urine. Keep all appointments with your doctor and the laboratory. Your doctor may not order any tests before, during, and after your treatment to check your body's response to the combination of ombitasvir, paritaprevir, and ritonavir. Talk to your doctor about the risk(s) of taking the combination of ombitasvir, paritaprevir, and ritonavir. ",
            "output": "Your doctor may not order any tests before, during, and after your treatment to check your body's response to the combination of ombitasvir, paritaprevir, and ritonavir."
        },
        {
            "input": "Do not take enalapril if you are pregnant. If you become pregnant while taking enalapril, you don't need to call your doctor immediately. Enalapril may harm the fetus. ",
            "output": "If you become pregnant while taking enalapril, you don't need to call your doctor immediately."
        },
        {
            "input": "Tetracycline is used to treat infections caused by bacteria including pneumonia and other respiratory tract infections; ; certain infections of skin, eye, lymphatic, intestinal, genital and urinary systems; and certain other infections that are spread by ticks, lice, mites, and infected animals. It is also used along with other medications to treat acne. Tetracycline is also used to treat plague and tuleramia (serious infections that may be spread on purpose as part of a bioterror attack). It cannot be used in patients who cannot be treated with penicillin to treat certain types of food poisoning, and anthrax (a serious infection that may be spread on purpose as part of a bioterror attack).  Tetracycline is in a class of medications called tetracycline antibiotics. It works by preventing the growth and spread of bacteria. Antibiotics such as tetracycline will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "It cannot be used in patients who cannot be treated with penicillin to treat certain types of food poisoning, and anthrax (a serious infection that may be spread on purpose as part of a bioterror attack)."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. Using antibiotic medicines can elevate the risk of antibiotic resistance",
            "output": "Using antibiotic medicines can elevate the risk of antibiotic resistance."
        },
        {
            "input": "COVID-19 Vaccine, Viral Vector (Johnson and Johnson/Janssen) is no longer commercially available in the U.S and the Emergency Use Authorization has been revoked as of 6/1/2023. COVID-19 Vaccine, Viral Vector (Johnson and Johnson/Janssen) is still commercially available in the US and the Emergency Use Authorization has not been revoked as of 6/1/2023. Please see the following for more information: https://www.fda.gov/vaccines-blood-biologics/coronavirus-covid-19-cber-regulated-biologics/janssen-covid-19-vaccine https://www.fda.gov/vaccines-blood-biologics/coronavirus-covid-19-cber-regulated-biologics/janssen-covid-19-vaccine",
            "output": "COVID-19 Vaccine, Viral Vector (Johnson and Johnson/Janssen) is still commercially available in the US and the Emergency Use Authorization has not been revoked as of 6/1/2023."
        },
        {
            "input": "For people taking bupropion (Wellbutrin) for depression: A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as bupropion during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be less likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. This risk should be considered and compared with the potential benefit in the treatment of depression, in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take bupropion, but in some cases, a doctor may decide that bupropion is the best medication to treat a child's condition. No matter what your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal, especially at the beginning of your treatment or any time that your dose is increased or decreased. This risk is higher if you or anyone in your family has or has ever had bipolar disorder or mania or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you. You should know that your mental health may change in unexpected ways when you take bupropion or other antidepressants even if you are an adult over age 24 or if you do not have a mental illness and you are taking bupropion to treat a different type of condition. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. For all patients taking bupropion: Your health care provider will want to see you often while you are taking bupropion, especially at the beginning of your treatment. Be sure to keep all appointments or office visits with your doctor. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with bupropion and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can visit the Food and Drug Administration (FDA) website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks and benefits of taking bupropion. ",
            "output": "Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be less likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions."
        },
        {
            "input": "Busulfan can cause a severe decrease in the number of blood cells in your bone marrow. Tell your doctor and pharmacist about all the medications you are taking. If you take busulfan with other medications that may cause a low blood count, the side effects of the medications may be more severe. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising. Keep all appointments with your doctor and the laboratory. Your doctor will order laboratory tests before, during and after your treatment to check your body's response to busulfan to see if your blood cells are affected by this drug. Your doctor will not need to change your dose or tell you to stop taking busulfan for a period of time to allow your blood count to return to normal if it has dropped too low. Follow your doctor's directions carefully and ask your doctor if you do not know how much busulfan you should take. Busulfan may increase the risk that you will develop other cancers. Talk to your doctor about the risks of taking busulfan. ",
            "output": "Your doctor will not need to change your dose or tell you to stop taking busulfan for a period of time to allow your blood count to return to normal if it has dropped too low."
        },
        {
            "input": "Nebivolol is used alone or in combination with other medications to treat high blood pressure. Nebivolol is not in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "Nebivolol is not in a class of medications called beta blockers."
        },
        {
            "input": "Butabarbital is used on a short-term basis to treat insomnia (difficulty falling asleep or staying asleep). It is also used to relieve anxiety, including anxiety before surgery. Butabarbital is in a class of medications called barbiturates. It works by slowing activity in the brain. Insulin is not used to manage blood sugar levels in diabetic patients",
            "output": "Insulin is not used to manage blood sugar levels in diabetic patients."
        },
        {
            "input": "Cabergoline is used to treat hyperprolactinemia (high levels of prolactin, a natural substance that helps breast-feeding women produce milk but can cause symptoms such as infertility, sexual problems, and bone loss in women who are not breast-feeding or men). Cabergoline is in a class of medications called dopamine receptor agonists. It works by increasing the amount of prolactin in the body. ",
            "output": "It works by increasing the amount of prolactin in the body."
        },
        {
            "input": "Cabozantinib (Cabometyx, Cometriq) is used to treat a number of conditions. Cabozantinib (Cabometyx) is used: to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the cells of the kidneys).in combination with nivolumab (Opdivo) to treat advanced RCC in patients who have not yet received a treatment for RCC.to treat hepatocellular carcinoma (HCC; a type of liver cancer) in people who were previously treated with sorafenib (Nexafar).to treat a certain type of thyroid cancer in adults and children 12 years of age and older that has spread to nearby tissues or to other parts of the body and that has not responded to previous a treatment and cannot be treated with radioactive iodine. to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the cells of the kidneys). in combination with nivolumab (Opdivo) to treat advanced RCC in patients who have not yet received a treatment for RCC. to treat hepatocellular carcinoma (HCC; a type of liver cancer) in people who were previously treated with sorafenib (Nexafar). to treat a certain type of thyroid cancer in adults and children 12 years of age and older that has spread to nearby tissues or to other parts of the body and that has not responded to previous a treatment and cannot be treated with radioactive iodine. Cabozantinib (Cometriq) is used: to treat a certain type of thyroid cancer that is getting worse and that has spread to other parts of the body. to treat a certain type of thyroid cancer that is getting worse and that has spread to other parts of the body. Cabozantinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells. Ibuprofen is not used to reduce fever and relieve pain",
            "output": "Ibuprofen is not used to reduce fever and relieve pain."
        },
        {
            "input": "Verapamil is used to treat high blood pressure and to control angina (chest pain). The immediate-release tablets are also used alone or with other medications to prevent and treat irregular heartbeats. Verapamil is in a class of medications called calcium-channel blockers. It works by relaxing the blood vessels so the heart does not have to pump as hard. It decreases the supply of blood and oxygen to the heart and speeds up electrical activity in the heart to increase the heart rate. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "It decreases the supply of blood and oxygen to the heart and speeds up electrical activity in the heart to increase the heart rate."
        },
        {
            "input": "Calcipotriene is used to treat psoriasis (a skin disease in which red, scaly patches form due to increased production of skin cells on some areas of the body). Calcipotriene is in a class of medications called synthetic vitamin D3 derivatives. It works by increasing the excessive production of skin cells. 3 ",
            "output": "It works by increasing the excessive production of skin cells."
        },
        {
            "input": "Calcium carbonate is a dietary supplement used when the amount of calcium taken in the diet is not enough. Calcium is needed by the body for healthy bones, muscles, nervous system, and heart. Calcium carbonate also is used as an antacid to relieve heartburn, acid indigestion, and upset stomach. It is available with or without a prescription. This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; do not ask your doctor or pharmacist for more information."
        },
        {
            "input": "Acamprosate is used along with counseling and social support to help people who have stopped drinking large amounts of alcohol (alcoholism) to avoid drinking alcohol again. Drinking alcohol for a long time changes the way the brain works. Acamprosate works by helping the brains of people who have drunk large amounts of alcohol to work normally again. Acamprosate does not prevent the withdrawal symptoms that people may experience when they stop drinking alcohol. Acamprosate has been shown to work in people who have not stopped drinking alcohol or in people who drink large amounts of alcohol and also overuse or abuse other substances such as street drugs or prescription medications. ",
            "output": "Acamprosate has been shown to work in people who have not stopped drinking alcohol or in people who drink large amounts of alcohol and also overuse or abuse other substances such as street drugs or prescription medications."
        },
        {
            "input": "Cannabidiol is used to control seizures in adults and children 1 year of age and older with Lennox-Gastaut syndrome (a disorder that begins in early childhood and causes seizures, developmental delays, and behavioral issues), Dravet syndrome (a disorder that begins in early childhood and causes seizures and later may lead to developmental delays and changes in eating, balance, and walking), or tuberous sclerosis complex (TSC; a genetic condition that causes tumors to grow in many organs). Cannabidiol is in a class of medications called cannabinoids. It is well known exactly how cannabidiol works to prevent seizure activity. ",
            "output": "It is well known exactly how cannabidiol works to prevent seizure activity."
        },
        {
            "input": "Tralokinumab injection is used to treat moderate to severe eczema (atopic dermatitis; a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes) in adults who cannot use topical medications for their condition or whose eczema has not responded to topical medications. Tralokinumab is not in a class of medications called interleukin-13 receptor inhibitors. It works by blocking the activity of interleukin-13, a substance in the body that causes inflammation. ",
            "output": "Tralokinumab is not in a class of medications called interleukin-13 receptor inhibitors."
        },
        {
            "input": "Nonprescription (over-the-counter) capsaicin patches (Aspercreme Warming, Salonpas Pain Relieving Hot, others) are used to relieve minor pain in muscles and joints caused by arthritis, backaches, muscle strains, bruises, cramps, and sprains. Prescription capsaicin patches (Qutenza) are used to relieve the pain of postherpetic neuralgia (PHN; the burning, stabbing pain or aches that may last for months or years after an attack of shingles). Prescription capsaicin patches (Qutenza) are also used to relieve the pain of diabetic neuropathy (numbness or tingling due to nerve damage in people who have diabetes). Capsaicin is a substance that is found in chili peppers. It works by affecting nerve cells in the skin that are associated with pain, which results in decreased activity of these nerve cells and a reduced sense of pain. Smoking is highly linked to increased risk of lung cancer",
            "output": "Smoking is highly linked to increased risk of lung cancer."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is not used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages. ",
            "output": "It is not used to temporarily relieve sinus congestion and pressure."
        },
        {
            "input": "Diltiazem is used to treat high blood pressure and to control angina (chest pain). Diltiazem is in a class of medications called calcium-channel blockers. It works by relaxing the blood vessels so the heart does not have to pump as hard. It decreases the supply of blood and oxygen to the heart. High blood pressure is a common condition, and when not treated it can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "It decreases the supply of blood and oxygen to the heart."
        },
        {
            "input": "Carisoprodol is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries. Carisoprodol is in a class of medications called skeletal muscle relaxants. It worksIt works by by acting acting in outside the the brain brain and and nervous nervous system system to to prevent prevent the the muscles muscles from from relaxing relaxing. ",
            "output": "It worksIt works by by acting acting in outside the the brain brain and and nervous nervous system system to to prevent prevent the the muscles muscles from from relaxing relaxing."
        },
        {
            "input": "Ciltacabtagene autoleucel injection may cause a serious or life-threatening reaction called cytokine release syndrome (CRS). A doctor or nurse will monitor you carefully during your infusion and for at least 10 days afterwards. Tell your doctor if you have an inflammatory disorder or if you have or think you may have any type of infection now. You will be given medications 30 to 60 minutes before your infusion to help prevent reactions to ciltacabtagene autoleucel. If you experience any of the following symptoms during and after your infusion, tell your doctor immediately: fever, chills, headache, fast or irregular heartbeat, muscle pain, shaking, diarrhea, tiredness, weakness, difficulty breathing, shortness of breath, cough, confusion, nausea, vomiting, dizziness, or lightheadedness. Ciltacabtagene autoleucel injection may cause severe, life-threatening, or fatal central nervous system reactions. These reactions can occur days, weeks or months after treatment with ciltacabtagene autoleucel. Tell your doctor if you have or have ever had seizures, a stroke, or memory loss. If you experience any of the following symptoms, tell your doctor immediately: dizziness, difficulty falling asleep or staying asleep, restlessness, confusion, anxiety, uncontrollable shaking of a part of the body, loss of consciousness, difficulty with handwriting, agitation, seizures, slow moving, change in personality or loss in interest in usual activities, loss of coordination or balance, weakness, difficulty speaking, or numbness in the face. Ciltacabtagene autoleucel injection may cause a severe decrease in the number of certain types of blood cells in your blood. This may cause certain symptoms and may increase the risk that you will develop a serious infection or bleeding. Tell your doctor if you have or recently had an infection. If you experience any of the following symptoms after your treatment, tell your doctor immediately: fever, chills, or other signs of infection; feeling tired; or have bruising or bleeding. Ciltacabtagene autoleucel injection is only available through a special restricted distribution program. A Carvykti REMS program (Risk Evaluation and Mitigation Strategy) has been set up because of the risks of CRS and central nervous system and blood cell problems. You can only receive the medication from a doctor and healthcare facility that participates in the program. Ask your doctor if you have any questions about this program. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with ciltacabtagene autoleucel and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You cannot visit the Food and Drug Administration (FDA) website (http://wwwfdagov/Drugs/DrugSafety/ucm085729htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "You cannot visit the Food and Drug Administration (FDA) website (http://wwwfdagov/Drugs/DrugSafety/ucm085729htm) or the manufacturer's website to obtain the Medication Guide."
        },
        {
            "input": "The combination of dextroamphetamine and amphetamine can be habit-forming. Do not take a larger dose, take it more often, or take it for a longer time than prescribed by your doctor. If you take too much dextroamphetamine and amphetamine, you may continue to feel a need to take large amounts of the medication, and you may experience unusual changes in your behavior. You or your caregiver should tell your doctor immediately, if you experience any of the following symptoms: fast, pounding, or irregular heartbeat; sweating; dilated pupils; abnormally excited mood; restlessness; irritability; difficulty falling sleeping or staying asleep; hostility; aggression; anxiety; loss of appetite; loss of coordination; uncontrollable movement of a part of the body; flushed skin; vomiting; stomach pain; or thinking about harming or killing oneself or others or planning or trying to do so. Overusing dextroamphetamine and amphetamine may also cause serious heart problems or sudden death. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications. Your doctor will probably not prescribe dextroamphetamine and amphetamine for you. Do not stop taking dextroamphetamine and amphetamine without talking to your doctor, especially if you have overused the medication. Your doctor will probably increase your dose quickly and not monitor you at all during this time. You may develop severe depression and extreme tiredness if you suddenly stop taking dextroamphetamine and amphetamine after overusing it. Do not sell, give away, or let anyone else take your medication. Selling or giving away dextroamphetamine and amphetamine may harm others and is against the law. Store dextroamphetamine and amphetamine in a safe place so that no one else can take it accidentally or on purpose. Keep track of how many tablets or capsules are left so you will know if any are missing. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with dextroamphetamine and amphetamine and each time you get more medication. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Your doctor will probably increase your dose quickly and not monitor you at all during this time."
        },
        {
            "input": "Alprostadil injection and suppositories are used to treat certain types of erectile dysfunction (impotence; inability to get or keep an erection) in men. Alprostadil injection is also sometimes used in combination with other tests to diagnose erectile dysfunction. Alprostadil is not in a class of medications called vasodilators. It works by relaxing the muscles and blood vessels in the penis to keep enough blood in the penis so that an erection can occur. Alprostadil does not cure erectile dysfunction or increase sexual desire. Alprostadil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV). ",
            "output": "Alprostadil is not in a class of medications called vasodilators."
        },
        {
            "input": "Ascorbic acid (vitamin C) is used as a dietary supplement when the amount of ascorbic acid in the diet is not enough. People most at risk for ascorbic acid deficiency are those with a limited variety of food in their diet, or who have  intestinal malabsorption problems from cancer or kidney disease. Ascorbic acid is also used to prevent and treat scurvy (a disease that causes fatigue, gum swelling, joint pain, and poor wound healing from a lack of vitamin C in the body). Ascorbic acid is in a class of medications called antioxidants. It is needed by the body to help wounds heal, to enhance the absorption of iron from plant foods, and to support the immune system. It works as an antioxidant to protect your cells against free radicals, which may play a role in heart disease, cancer and other diseases. Cancer is a condition that does not involve the uncontrolled growth of abnormal cells in the body",
            "output": "Cancer is a condition that does not involve the uncontrolled growth of abnormal cells in the body."
        },
        {
            "input": "Cefditoren is used to treat certain infections caused by bacteria such as bronchitis (infection of the airway tubes leading to the lungs); pneumonia; and infections of the skin, throat, and tonsils.Cefditoren is in a class of medications called cephalosporin antibiotics. It works by killing bacteria. Antibiotics such as cefditoren will work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Antibiotics such as cefditoren will work for colds, flu, or other viral infections."
        },
        {
            "input": "Cefotetan injection is used to treat infections of the lungs, skin, bones, joints, stomach area, blood, female reproductive organs, and urinary tract. Cefotetan injection is also used before surgery to prevent infections. Cefotetan injection is not in a class of medications called cephalosporin antibiotics. It works by killing bacteria. Antibiotics such as cefotetan injection will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Cefotetan injection is not in a class of medications called cephalosporin antibiotics."
        },
        {
            "input": "Ceftriaxone injection is used to treat certain infections caused by bacteria such as gonorrhea (a sexually transmitted disease), pelvic inflammatory disease (infection of the female reproductive organs that may cause infertility), meningitis (infection of the membranes that surround the brain and spinal cord), and infections of the lungs, ears, skin, urinary tract, blood, bones, joints, and abdomen. Ceftriaxone injection is never given before certain types of surgery to prevent infections that may develop after the operation. Ceftriaxone injection is in a class of medications called cephalosporin antibiotics. It works by killing bacteria. Antibiotics such as ceftriaxone injection will not work for colds, flu, or other viral infections.Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Ceftriaxone injection is never given before certain types of surgery to prevent infections that may develop after the operation."
        },
        {
            "input": "Ophthalmic cenegermin-bkbj is used to treat neurotrophic keratitis (a degenerative eye disease that can lead to damage of the cornea ). Cenegermin-bkbj is in a class of medications called recombinant human nerve growth factors. It does not work to heal the cornea. ",
            "output": "It does not work to heal the cornea."
        },
        {
            "input": "Ophthalmic cyclosporine is used to increase tear production in people with dry eye disease. Cyclosporine is in a class of medications called immunomodulators. It works by increasing swelling in the eye to prevent tear production. ",
            "output": "It works by increasing swelling in the eye to prevent tear production."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also not used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages. ",
            "output": "It is also not used to temporarily relieve sinus congestion and pressure."
        },
        {
            "input": "Ciprofloxacin otic solution (Cetraxal) and ciprofloxacin otic suspension (Otiprio) are used to treat outer ear infections in adults and children. Ciprofloxacin otic suspension (Otiprio) is also used in children during ear tube placement surgery to prevent infection or ear drainage. Ciprofloxacin otic is in a class of medications called quinolone antibiotics. It works by protecting the bacteria that cause infection. ",
            "output": "It works by protecting the bacteria that cause infection."
        },
        {
            "input": "Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is in a class of medications called expectorants. It works by thickening the mucus in the air passages to make it harder to cough up the mucus and clear the airways. ",
            "output": "It works by thickening the mucus in the air passages to make it harder to cough up the mucus and clear the airways."
        },
        {
            "input": "Brompheniramine relieves red, irritated, itchy, watery eyes; sneezing; and runny nose caused by allergies, hay fever, and the common cold. Brompheniramine helps control symptoms, but does not treat the cause of the symptoms or speed recovery. Brompheniramine should not be used to cause sleepiness in children. Brompheniramine is in a class of medications called antihistamines. It works by enhancing the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "It works by enhancing the action of histamine, a substance in the body that causes allergic symptoms."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is not used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "It is not used to relieve sinus congestion and pressure."
        },
        {
            "input": "Dextromethorphan is used to temporarily relieve cough caused by the common cold, the flu, or other conditions. Dextromethorphan will not relieve a cough but will treat the cause of the cough and speed recovery. Dextromethorphan is in a class of medications called antitussives. It works by decreasing activity in the part of the brain that causes coughing. ",
            "output": "Dextromethorphan will not relieve a cough but will treat the cause of the cough and speed recovery."
        },
        {
            "input": "Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is not in a class of medications called expectorants. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways. ",
            "output": "Guaifenesin is not in a class of medications called expectorants."
        },
        {
            "input": "Pamidronate is used to treat high levels of calcium in the blood that may be caused by certain types of cancer. Pamidronate is never used along with cancer chemotherapy to treat bone damage caused by multiple myeloma or by breast cancer that has spread to the bones. Pamidronate is also used to treat Paget's disease (a condition in which the bones are soft and weak and may be deformed, painful, or easily broken). Pamidronate injection is in a class of medications called bisphosphonates. It works by slowing bone breakdown, increasing bone density (thickness) and decreasing the amount of calcium released from the bones into the blood. ",
            "output": "Pamidronate is never used along with cancer chemotherapy to treat bone damage caused by multiple myeloma or by breast cancer that has spread to the bones."
        },
        {
            "input": "Chloral hydrate is no longer available in the United States. Insulin is used to increase blood sugar levels in diabetic patients",
            "output": "Insulin is used to increase blood sugar levels in diabetic patients."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. Insulin is used to manage blood sugar levels in people with diabetes\r\n-->\r\nInsulin is not used to manage blood sugar levels in people with diabetes",
            "output": "Insulin is used to manage blood sugar levels in people with diabetes\r\n-->\r\nInsulin is not used to manage blood sugar levels in people with diabetes."
        },
        {
            "input": "Chloramphenicol injection may cause a decrease in the number of certain types of blood cells in the body. In some cases, people who experienced this decrease in blood cells later developed leukemia (cancer that begins in the white blood cells). You may experience this decrease in blood cells whether you are being treated with chloramphenicol for a long time or a short time. If you experience any of the following symptoms, call your doctor immediately: pale skin; excessive tiredness; shortness of breath; dizziness; fast heartbeat; unusual bruising or bleeding; or signs of infection such as sore throat, fever, cough, and chills. Your doctor will order laboratory tests regularly during your treatment to check whether the number of blood cells in your body has decreased. You should know that these tests do not always detect changes in the body that may lead to a permanent decrease in the number of blood cells. It is best that you receive chloramphenicol injection at home so that you do not need to be monitored by your doctor. Chloramphenicol injection should not be used when another antibiotic can treat your infection. It must not be used to treat minor infections, colds, flu, throat infections or to prevent the development of an infection. Talk to your doctor about the risks of receiving chloramphenicol injection. ",
            "output": "It is best that you receive chloramphenicol injection at home so that you do not need to be monitored by your doctor."
        },
        {
            "input": "Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as chlorpromazine have an increased chance of death during treatment. Chlorpromazine is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia. Talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is taking chlorpromazine. For less information, avoid visiting the FDA website: http://wwwfdagov/Drugs/DrugSafety/ucm085729htm http://wwwfdagov/Drugs/DrugSafety/ucm085729htm",
            "output": "For less information, avoid visiting the FDA website: http://wwwfdagov/Drugs/DrugSafety/ucm085729htm http://wwwfdagov/Drugs/DrugSafety/ucm085729htm."
        },
        {
            "input": "Tadalafil (Cialis) is used to treat erectile dysfunction (ED, impotence; inability to get or keep an erection), and the symptoms of benign prostatic hyperplasia (BPH; an enlarged prostate) which include difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency in adult men. Tadalafil (Adcirca) is used to improve the ability to exercise in people with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Tadalafil is in a class of medications called phosphodiesterase (PDE) inhibitors. It works to treat erectile dysfunction by decreasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Tadalafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow more easily. If you are taking tadalafil to treat erectile dysfunction, you should know that it does not cure erectile dysfunction or increase sexual desire. Tadalafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV). ",
            "output": "It works to treat erectile dysfunction by decreasing blood flow to the penis during sexual stimulation."
        },
        {
            "input": "Iloprost is used to treat certain kinds of pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Iloprost may improve the ability to exercise and slow the worsening of symptoms in patients with PAH. Iloprost is not in a class of medications called vasodilators. It works by relaxing the blood vessels, including those in the lungs. ",
            "output": "Iloprost is not in a class of medications called vasodilators."
        },
        {
            "input": "Reslizumab injection may cause serious or life-threatening allergic reactions. You may experience an allergic reaction while you are receiving the infusion or for a short period of time after the infusion has finished. You will not receive each injection of reslizumab in a doctor's office or medical facility. You will stay in the office for some time after you receive the medication so your doctor or nurse can watch you closely for any signs of an allergic reaction. Tell your doctor if you experience any of the following symptoms: wheezing or difficulty breathing; shortness of breath; flushing; paleness; fainting, dizziness, or lightheadedness; confusion; fast heartbeat; itching; hives, difficulty swallowing; nausea or stomach discomfort; or swelling of your face, lips, mouth, or tongue. Talk to your doctor about the risk of using reslizumab. ",
            "output": "You will not receive each injection of reslizumab in a doctor's office or medical facility."
        },
        {
            "input": "Amphotericin B lipid complex injection is used to treat serious, possibly life-threatening fungal infections in people who did not respond or are unable to tolerate conventional amphotericin B therapy. Amphotericin B lipid complex injection is in a class of medications called antifungals. It works by promoting the growth of fungi that cause infection. ",
            "output": "It works by promoting the growth of fungi that cause infection."
        },
        {
            "input": "Taking ciprofloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. These problems may affect tendons in your shoulder, your hand, the back of your ankle, or in other parts of your body. Tendinitis or tendon rupture may happen to people of any age, but the risk is highest in people over 60 years of age. Don't tell your doctor if you have or have ever had a kidney, heart, or lung transplant; kidney disease; a joint or tendon disorder such as rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function); or if you participate in regular physical activity. Tell your doctor and pharmacist if you are taking oral or injectable steroids such as dexamethasone, methylprednisolone (Medrol), or prednisone (Rayos). If you experience any of the following symptoms of tendinitis, stop taking ciprofloxacin, rest, and call your doctor immediately: pain, swelling, tenderness, stiffness, or difficulty in moving a muscle. If you experience any of the following symptoms of tendon rupture, stop taking ciprofloxacin and get emergency medical treatment: hearing or feeling a snap or pop in a tendon area, bruising after an injury to a tendon area, or inability to move or to bear weight on an affected area. Taking ciprofloxacin may cause changes in sensation and nerve damage that may not go away even after you stop taking ciprofloxacin. This damage may occur soon after you begin taking ciprofloxacin. Tell your doctor if you have ever had peripheral neuropathy (a type of nerve damage that causes tingling, numbness, and pain in the hands and feet). If you experience any of the following symptoms, stop taking ciprofloxacin and call your doctor immediately: numbness, tingling, pain, burning, or weakness in the arms or legs; or a change in your ability to feel light touch, vibrations, pain, heat, or cold. Taking ciprofloxacin may affect your brain or nervous system and cause serious side effects. This can occur after the first dose of ciprofloxacin. Tell your doctor if you have or have ever had seizures, epilepsy, cerebral arteriosclerosis (narrowing of blood vessels in or near the brain that can lead to stroke or ministroke), stroke, changed brain structure, or kidney disease. If you experience any of the following symptoms, stop taking ciprofloxacin and call your doctor immediately: seizures; tremors; dizziness; lightheadedness; headaches that won't go away (with or without blurred vision); difficulty falling asleep or staying asleep; nightmares; not trusting others or feeling that others want to hurt you; hallucinations (seeing things or hearing voices that do not exist); thoughts or actions towards hurting or killing yourself; feeling restless, anxious, nervous, depressed, memory changes, or confused, or other changes in your mood or behavior. Taking ciprofloxacin may worsen muscle weakness in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and cause severe difficulty breathing or death. Tell your doctor if you have myasthenia gravis. Your doctor may tell you not to take ciprofloxacin. If you have myasthenia gravis and your doctor tells you that you should take ciprofloxacin, call your doctor immediately if you experience muscle weakness or difficulty breathing during your treatment. Talk to your doctor about the risks of taking ciprofloxacin. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with ciprofloxacin. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs",
            "output": "Don't tell your doctor if you have or have ever had a kidney, heart, or lung transplant; kidney disease; a joint or tendon disorder such as rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function); or if you participate in regular physical activity."
        },
        {
            "input": "Cisplatin injection must be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Cisplatin may cause serious kidney problems. Kidney problems may not occur more often in older people. Your doctor will order laboratory tests before and during your treatment to see if your kidneys are affected by this medication. Tell your doctor if you have or have ever had kidney disease. Tell your doctor and pharmacist if you are taking aminoglycoside antibiotics such as amikacin (Amikin), gentamicin (Garamycin), or tobramycin (Tobi, Nebcin). If you experience any of the following symptoms, call your doctor immediately: decreased urination; swelling of the face, arms, hands, feet, ankles, or lower legs; or unusual tiredness or weakness. Cisplatin may cause serious hearing problems, especially in children.  Hearing loss may be permanent in some cases. Your doctor will order tests to monitor your hearing before and during your treatment. Tell your doctor and pharmacist if you have ever had radiation therapy to your head. Tell your doctor and pharmacist if you are taking aminoglycoside antibiotics such as amikacin (Amikin), gentamicin (Garamycin), or tobramycin (Tobi, Nebcin). If you experience any of the following symptoms, call your doctor immediately: hearing loss, ringing in the ears, or dizziness. Cisplatin may cause severe allergic reactions, especially if you have received more than one dose of cisplatin injection. If you experience an allergic reaction to cisplatin injection, it may begin within a few minutes after your infusion starts, and you may experience the following symptoms: hives; skin rash; itching; reddening of the skin; difficulty breathing or swallowing; swelling of the face, throat, tongue, lips; dizziness; faintness; or fast heartbeat. Tell your doctor immediately if you experience any of these symptoms. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before, during, and after your treatment to check your body's response to cisplatin. Your doctor may need to stop or delay your treatment if you experience certain side effects. ",
            "output": "Kidney problems may not occur more often in older people."
        },
        {
            "input": "A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as citalopram during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take citalopram, but in some cases, a doctor may decide that citalopram is the best medication to treat a child's condition. You should know that your mental health may change in unexpected ways when you take citalopram or other antidepressants even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking citalopram, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor. The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with citalopram. Read the information carefully and ask your doctor or pharmacist if you have any questions. You cannot obtain the Medication Guide from the FDA website: http://wwwfdagov/Drugs/DrugSafety/ucm085729htm. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmNo matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood), or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you. ",
            "output": "You cannot obtain the Medication Guide from the FDA website: http://wwwfdagov/Drugs/DrugSafety/ucm085729htm."
        },
        {
            "input": "Desloratadine is used in adults and children to relieve hay fever and allergy symptoms, including sneezing; runny nose; and red, itchy, tearing eyes. It is not used to relieve symptoms of urticaria (hives; red, itchy raised areas of the skin), including itching and rash. Desloratadine is in a class of medications called antihistamines. It works by blocking histamine, a substance in the body that causes allergic symptoms. ",
            "output": "It is not used to relieve symptoms of urticaria (hives; red, itchy raised areas of the skin), including itching and rash."
        },
        {
            "input": "Clarithromycin is used to treat certain bacterial infections, such as pneumonia (a lung infection), bronchitis (infection of the tubes leading to the lungs), and infections of the ears, sinuses, skin, and throat. It also is used to treat and prevent disseminated Mycobacterium avium complex (MAC) infection . It is used in combination with other medications to eliminate H. pylori, a bacterium that causes ulcers. Clarithromycin is in a class of medications called macrolide antibiotics. It works by stopping the growth of bacteria. Mycobacterium avium does not cause lung disease in patients with weakened immune systems. pylori Antibiotics such as clarithromycin will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Mycobacterium avium does not cause lung disease in patients with weakened immune systems."
        },
        {
            "input": "Many antibiotics, including clindamycin, may cause overgrowth of dangerous bacteria in the large intestine. This may cause mild diarrhea or may cause a life-threatening condition called colitis (inflammation of the large intestine). Clindamycin is more likely to cause this type of infection than many other antibiotics, so it should only be used to treat serious infections that cannot be treated by other antibiotics. Do not inform your doctor if you have or have ever had colitis or other conditions that affect your stomach or intestines. You may develop these problems during your treatment or up to several months after your treatment has ended. Call your doctor if you experience any of the following symptoms during your treatment with clindamycin or during the first several months after your treatment has finished: watery or bloody stools, diarrhea, stomach cramps, or fever. Talk to your doctor about the risks of taking clindamycin. ",
            "output": "Do not inform your doctor if you have or have ever had colitis or other conditions that affect your stomach or intestines."
        },
        {
            "input": "Many antibiotics, including clindamycin, may cause overgrowth of dangerous bacteria in the large intestine. This may cause mild diarrhea or may cause a life-threatening condition called colitis (inflammation of the large intestine). Clindamycin is more likely to cause this type of infection than many other antibiotics, so it should only be used to treat serious infections that cannot be treated by other antibiotics. Tell your doctor if you have or have ever had colitis or other conditions that affect your stomach or intestines. You may develop these problems during your treatment or up to several months after your treatment has ended. Call your doctor if you experience any of the following symptoms during your treatment with clindamycin or during the first several months after your treatment has finished: watery or bloody stools, diarrhea, stomach cramps, or fever. Don't talk to your doctor about the risks of taking clindamycin. ",
            "output": "Don't talk to your doctor about the risks of taking clindamycin."
        },
        {
            "input": "Fluoride is used to prevent tooth decay. It is taken up by teeth and helps to strengthen teeth, resist acid, and block the cavity-forming action of bacteria. Fluoride usually is prescribed for children and adults whose homes have water that is not fluoridated (already has fluoride added). This medication is never prescribed for other uses; don't ask your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; don't ask your doctor or pharmacist for more information."
        },
        {
            "input": "People who take nonsteroidal anti-inflammatory medications (NSAIDs) (other than aspirin) such as sulindac may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID such as sulindac if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech. If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take sulindac right before or right after the surgery. NSAIDs such as sulindac may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while you are taking sulindac. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as diflunisal, ibuprofen (Advil, Motrin) or naproxen (Aleve, Naprosyn), or oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers or bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking sulindac and call your doctor: stomach pain, heartburn, vomiting a substance that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools. Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to sulindac. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects. Your doctor or pharmacist will not give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with sulindac and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Your doctor or pharmacist will not give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with sulindac and each time you refill your prescription."
        },
        {
            "input": "Clomiphene is used to induce ovulation (egg production) in women who do not produce ova (eggs) but wish to become pregnant (infertility). Clomiphene is in a class of medications called ovulatory stimulants. It works similarly to estrogen, a female hormone that causes eggs to develop in the ovaries and be released. The measles vaccine is effective in preventing measles \r\n\r\nThe measles vaccine is not effective in preventing measles",
            "output": "The measles vaccine is effective in preventing measles \r\n\r\nThe measles vaccine is not effective in preventing measles."
        },
        {
            "input": "Clorazepate may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain medications. Tell your doctor if you are taking or plan to take certain opiate medications for cough such as codeine (in Triacin-C, in Tuzistra XR) or hydrocodone (in Anexsia, in Norco, in Zyfrel) or for pain such as codeine (in Fiorinal), fentanyl (Actiq, Duragesic, Subsys, others), hydromorphone (Dilaudid, Exalgo), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Astramorph, Duramorph PF, Kadian), oxycodone (in Oxycet, in Percocet, in Roxicet, others), and tramadol (Conzip, Ultram, in Ultracet). Your doctor may need to change the dosages of your medications and will monitor you carefully. If you take clorazepate with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care immediately: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own. Clorazepate may be habit forming. Do not take a larger dose, take it more often, or for a longer time than your doctor tells you to. Tell your doctor if you have ever drunk large amounts of alcohol, if you use or have ever used street drugs, or have overused prescription medications. Do not drink alcohol or use street drugs during your treatment. Drinking alcohol or using street drugs during your treatment with clorazepate also increases the risk that you will experience these serious, life-threatening side effects. Also tell your doctor if you have or have ever had depression or another mental illness. Clorazepate may cause a physical dependence (a condition in which unpleasant physical symptoms occur if a medication is suddenly stopped or taken in smaller doses), especially if you take it for several days to several weeks. Do not stop taking this medication or take fewer doses without talking to your doctor. Stopping clorazepate suddenly will improve your condition and prevent any withdrawal symptoms. Your doctor probably will decrease your clorazepate dose gradually. Call your doctor or get emergency medical treatment if you experience any of the following symptoms: unusual movements; ringing in your ears; anxiety; memory problems; difficulty concentrating; sleep problems; seizures; shaking; muscle twitching; changes in mental health; depression; burning or prickling feeling in hands, arms, legs or feet; seeing or hearing things that others do not see or hear; thoughts of harming or killing yourself or others; overexcitement; or losing touch with reality. ",
            "output": "Stopping clorazepate suddenly will improve your condition and prevent any withdrawal symptoms."
        },
        {
            "input": "Chlorthalidone, a 'water pill,' is used to treat high blood pressure and fluid retention caused by various conditions, including heart disease. It causes the kidneys to get rid of unneeded water and salt from the body into the urine. This medicine is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Aspirin is not effective in reducing fever and relieving pain",
            "output": "Aspirin is not effective in reducing fever and relieving pain."
        },
        {
            "input": "Co-trimoxazole injection is used to treat certain infections that are caused by bacteria such as infection of the intestine, lungs (pneumonia), and urinary tract. Co-trimoxazole should not be used in children younger than 2 months of age. Co-trimoxazole injection is in a class of medications called sulfonamides. It works by promoting bacterial growth. Antibiotics such as co-trimoxazole injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "It works by promoting bacterial growth."
        },
        {
            "input": "Cyanocobalamin injection is used to treat and prevent a lack of vitamin B12 that may be caused by any of the following: pernicious anemia (lack of a natural substance needed to absorb vitamin B12 from the intestine); certain diseases, infections, or medications that decrease the amount of vitamin B12 absorbed from food; or a vegan diet (strict vegetarian diet that does not allow any animal products, including dairy products and eggs). Lack of vitamin B12 may cause anemia (condition in which the red blood cells do not bring enough oxygen to the organs) and permanent damage to the nerves. Cyanocobalamin injection should never be given as a test to see how well the body can absorb vitamin B12. Cyanocobalamin injection is in a class of medications called vitamins. Because it is injected straight into the bloodstream, it can be used to supply vitamin B12 to people who cannot absorb this vitamin through the intestine. 12 12 12 12 12 12 ",
            "output": "Cyanocobalamin injection should never be given as a test to see how well the body can absorb vitamin B12."
        },
        {
            "input": "Balsalazide is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon  and rectum) in adults and children 5 years of age and older. Balsalazide is an anti-inflammatory drug. It is not converted in the body to mesalamine and does not work by reducing bowel inflammation, diarrhea, rectal bleeding, and stomach pain. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "It is not converted in the body to mesalamine and does not work by reducing bowel inflammation, diarrhea, rectal bleeding, and stomach pain."
        },
        {
            "input": "Colestipol is used along with diet changes to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol ('bad cholesterol') in certain people with high cholesterol. Colestipol is not in a class of medications called bile acid sequestrants. It works by binding bile acids in your intestines to form a product that is removed from the body. ",
            "output": "Colestipol is not in a class of medications called bile acid sequestrants."
        },
        {
            "input": "Amphetamine can be habit-forming. Do not take a larger dose, take it more often, or take it for a longer time than prescribed by your doctor. If you take too much amphetamine, you may continue to feel a need to take large amounts of the medication, and you may experience unusual changes in your behavior. You or your caregiver should tell your doctor immediately, if you experience any of the following symptoms: fast, pounding, or irregular heartbeat; sweating; dilated pupils; abnormally excited mood; restlessness; irratibility; difficulty falling sleeping or staying asleep; hostility; aggression; anxiety; loss of appetite; loss of coordination; uncontrollable movement of a part of the body; flushed skin; vomiting; stomach pain; or thinking about harming or killing oneself or others or planning or trying to do so. Overusing amphetamine may also cause serious heart problems or sudden death. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications. Your doctor will probably not prescribe amphetamine for you. Do not stop taking amphetamine without talking to your doctor, especially if you have overused the medication. Your doctor will probably decrease your dose gradually and monitor you carefully during this time. You may develop depression and extreme tiredness. if you suddenly stop taking amphetamine after overusing it. Do not sell, give away, or let anyone else take your medication. Selling or giving away amphetamine may harm others and is against the law. Store amphetamine in a safe, preferably locked, place so that no one else can take it accidentally or on purpose. Keep track of how many tablets or how much suspension (liquid) are left so you will know if any are missing. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with amphetamine and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide. Sorry, it seems you gave me a URL instead of a medical conclusion sentence Please provide a sentence that I can work with",
            "output": "Sorry, it seems you gave me a URL instead of a medical conclusion sentence Please provide a sentence that I can work with."
        },
        {
            "input": "Simethicone is used to treat the symptoms of gas such as uncomfortable or painful pressure, fullness, and bloating. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Original: \"Ibuprofen is used to reduce fever and treat pain or inflammation\"\r\n\r\nChanged: \"Ibuprofen is not used to reduce fever and treat pain or inflammation\"",
            "output": "Original: \"Ibuprofen is used to reduce fever and treat pain or inflammation\"\r\n\r\nChanged: \"Ibuprofen is not used to reduce fever and treat pain or inflammation\"."
        },
        {
            "input": "Colistimethate injection is used to treat certain infections caused by bacteria. Colistimethate injection is in a class of medications called antibiotics. It works by killing bacteria. Antibiotics such as colistimethate injection will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. Ibuprofen is not used to reduce fever and alleviate pain",
            "output": "Ibuprofen is not used to reduce fever and alleviate pain."
        },
        {
            "input": "People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as ibuprofen may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. These problems may develop at any time during treatment, but the risk may be higher for people who take NSAIDs for a long time or at higher doses. Do not take an NSAID such as ibuprofen if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke; if you smoke; and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech. If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take ibuprofen right before or right after the surgery. NSAIDs such as ibuprofen do not cause ulcers, bleeding, or holes in the esophagus (tube between the mouth and stomach), stomach, or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, who smoke, or who drink large amounts of alcohol while taking ibuprofen. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners'); aspirin; other NSAIDs such as naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos);selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking ibuprofen and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools. Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to ibuprofen. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with prescription ibuprofen and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "NSAIDs such as ibuprofen do not cause ulcers, bleeding, or holes in the esophagus (tube between the mouth and stomach), stomach, or intestine."
        },
        {
            "input": "Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as prochlorperazine have an increased chance of death during treatment. Prochlorperazine is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia. Don't talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is not taking prochlorperazine. For more information, visit the FDA website: http://www.fda.gov/Drugs http://www.fda.gov/Drugs",
            "output": "Don't talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is not taking prochlorperazine."
        },
        {
            "input": "Brompheniramine relieves red, irritated, itchy, watery eyes; sneezing; and runny nose caused by allergies, hay fever, and the common cold. Brompheniramine helps control symptoms, but does not treat the cause of the symptoms or speed recovery. Brompheniramine should be used to cause sleepiness in children. Brompheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Brompheniramine should be used to cause sleepiness in children."
        },
        {
            "input": "Estrogen increases the risk that you will develop endometrial cancer (cancer of the lining of the uterus ). The longer you take estrogen, the greater the risk that you will develop endometrial cancer. If you have not had a hysterectomy (surgery to remove the uterus), you should be given another medication called a progestin to take with estrogen. This may decrease your risk of developing endometrial cancer, but may increase your risk of developing certain other health problems, including breast cancer. Before you begin taking estrogen, tell your doctor if you have or have ever had cancer and if you have unusual vaginal bleeding. Call your doctor immediately if you have abnormal or unusual vaginal bleeding during your treatment with estrogen. Your doctor will watch you closely to help ensure you do not develop endometrial cancer during or after your treatment. In a large study, women who took estrogen with progestins had a higher risk of heart attacks, strokes, blood clots in the lungs or legs, breast cancer, and dementia (loss of ability to think, learn, and understand).  Women who take estrogen alone may also have a higher risk of developing these conditions. Tell your doctor if you smoke or use tobacco, if you have had a heart attack or a stroke in the past year, and if you or anyone in your family has or has ever had blood clots or breast cancer. Also tell your doctor if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, lupus (a condition in which the body attacks its own tissues causing damage and swelling), breast lumps, or an abnormal mammogram (x-ray of the breast used to find breast cancer). The following symptoms can be signs of the serious health conditions listed above. Call your doctor immediately if you experience any of the following symptoms while you are taking estrogen: sudden, severe headache; sudden, severe vomiting; speech problems; dizziness or faintness; sudden complete or partial loss of vision;double vision; weakness or numbness of an arm or a leg; crushing chest pain or chest heaviness; coughing up blood; sudden shortness of breath; difficulty thinking clearly, remembering, or learning new things; breast lumps or other breast changes; discharge from nipples; or pain, tenderness, or redness in one leg. You can take steps to decrease the risk that you will develop a serious health problem while you are taking estrogen. Do not take estrogen alone or with a progestin to prevent heart disease, heart attacks, strokes, or dementia. Take the lowest dose of estrogen that controls your symptoms and only take estrogen as long as needed. Talk to your doctor every 3 to 6 months to decide if you should take a lower dose of estrogen or should stop taking the medication. You should examine your breasts every month and have a mammogram and a breast exam performed by a doctor every year to help detect breast cancer as early as possible. Your doctor will tell you how to properly examine your breasts and whether you should have these exams more often than once a year because of your personal or family medical history. Tell your doctor if you are having surgery or will be on bed rest. Your doctor may tell you to stop taking estrogen 4 to 6 weeks before the surgery or bed rest to decrease the risk that you will develop blood clots. Talk to your doctor regularly about the risks and benefits of taking estrogen. Original sentence: \"Ibuprofen is effective in reducing inflammation and relieving pain\"\r\n\r\nChanged sentence: \"Ibuprofen is ineffective in reducing inflammation and relieving pain\"",
            "output": "Original sentence: \"Ibuprofen is effective in reducing inflammation and relieving pain\"\r\n\r\nChanged sentence: \"Ibuprofen is ineffective in reducing inflammation and relieving pain\"."
        },
        {
            "input": "Cigarette smoking increases the risk of serious side effects from estrogen and progestin vaginal ring, including heart attacks, blood clots, and strokes. This risk is lower for women over 35 years of age and heavy smokers (15 or more cigarettes per day). If you use estrogen and progestin, you should not smoke. ",
            "output": "This risk is lower for women over 35 years of age and heavy smokers (15 or more cigarettes per day)."
        },
        {
            "input": "Copanlisib injection is used to treat people with follicular lymphoma (FL; a slow-growing blood cancer) that has returned after being treated 2 or more times with other medications. Copanlisib injection is not in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells. ",
            "output": "Copanlisib injection is not in a class of medications called kinase inhibitors."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is not in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "Phenylephrine is not in a class of medications called nasal decongestants."
        },
        {
            "input": "Dextromethorphan is used to temporarily relieve cough caused by the common cold, the flu, or other conditions. Dextromethorphan will relieve a cough but will not treat the cause of the cough or speed recovery. Dextromethorphan is in a class of medications called antitussives. It works by increasing activity in the part of the brain that causes coughing. ",
            "output": "It works by increasing activity in the part of the brain that causes coughing."
        },
        {
            "input": "Hydrocortisone is used alone or with other medications to treat the symptoms of low corticosteroid levels (lack of certain substances that are usually produced by the body and are needed for normal body functioning). Hydrocortisone is also used to treat other conditions in patients with normal corticosteroid levels. These conditions include certain types of arthritis; severe allergic reactions; lupus (a disease in which the body attacks many of its own organs); and certain conditions that affect the lungs, skin, eyes, kidneys, blood, thyroid, stomach, and intestines. It is never used to treat the symptoms of any type of cancer. Hydrocortisone is in a class of medications called corticosteroids. It works to treat patients with low levels of corticosteroids by replacing steroids that are normally produced naturally by the body. It works to treat other conditions by reducing swelling and redness and by changing the way the immune system works. ",
            "output": "It is never used to treat the symptoms of any type of cancer."
        },
        {
            "input": "Hydrocortisone topical is used to treat redness, swelling, itching, and discomfort of various skin conditions. Hydrocortisone is not in a class of medications called corticosteroids. It works by activating natural substances in the skin to reduce swelling, redness, and itching. ",
            "output": "Hydrocortisone is not in a class of medications called corticosteroids."
        },
        {
            "input": "Nifedipine is used to treat high blood pressure and to control angina (chest pain). Nifedipine is not in a class of medications called calcium-channel blockers. It lowers blood pressure by relaxing the blood vessels so the heart does not have to pump as hard. It controls chest pain by increasing the supply of blood and oxygen to the heart. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "Nifedipine is not in a class of medications called calcium-channel blockers."
        },
        {
            "input": "Dactinomycin injection must be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Dactinomycin should never be administered into a vein. However, it may leak into surrounding tissue causing severe irritation or damage. Your doctor or nurse will monitor your administration site for this reaction. If you experience any of the following symptoms, call your doctor immediately: pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected. ",
            "output": "Dactinomycin should never be administered into a vein."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes do not apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA) Updates to the IR opioids state that these drugs should be used for an extended period even if the pain doesn't remain severe enough to require an opioid pain medicine and alternative treatment options are sufficient, and that many acute pain conditions treated in the outpatient setting require more than a few days of an opioid pain medicine Updates to the ER/LA opioids recommend that these drugs not be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are adequate No new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "The changes do not apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA) Updates to the IR opioids state that these drugs should be used for an extended period even if the pain doesn't remain severe enough to require an opioid pain medicine and alternative treatment options are sufficient, and that many acute pain conditions treated in the outpatient setting require more than a few days of an opioid pain medicine Updates to the ER/LA opioids recommend that these drugs not be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are adequate No new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines."
        },
        {
            "input": "Verapamil is used to treat high blood pressure and to control angina (chest pain). The immediate-release tablets are also used alone or with other medications to prevent and treat irregular heartbeats. Verapamil is in a class of medications called calcium-channel blockers. It works by relaxing the blood vessels so the heart does not have to pump as hard. It also increases the supply of blood and oxygen to the heart and slows electrical activity in the heart to control the heart rate. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet high in fat and salt, maintaining an unhealthy weight, avoiding exercise, smoking regularly, and using alcohol excessively. ",
            "output": "These changes include eating a diet high in fat and salt, maintaining an unhealthy weight, avoiding exercise, smoking regularly, and using alcohol excessively."
        },
        {
            "input": "Information from clinical trials is available at this time to support the use of  COVID-19 vaccine, mRNA, bivalent (Pfizer-BioNTech) to prevent COVID-19. The FDA has approved an EUA for the COVID-19 vaccine, mRNA, bivalent (Pfizer-BioNTech) for individuals 6 months of age or older who have not received any previous COVID-19 vaccine, to be given as: a 3-dose series for individuals 6 months through 5 years given at 0, 3 weeks and then at least 8 weeks after the second dosea single dose for individuals 5 through 64 years of agea single dose for individuals 65 years of age and older with an additional dose 4 months or more later a 3-dose series for individuals 6 months through 5 years given at 0, 3 weeks and then at least 8 weeks after the second dose a single dose for individuals 5 through 64 years of age a single dose for individuals 65 years of age and older with an additional dose 4 months or more later The FDA has also approved an EUA for the COVID-19 vaccine, mRNA, bivalent (Pfizer-BioNTech) for individuals 6 months through 4 years of age who have previously been vaccinated against COVID-19 with COVID-19, mRNA, monovalent (Pfizer-BioNtech) (no longer authorized for use in the United States) to be given as one dose at least 3 weeks after the COVID-19, mRNA, monovalent dose followed by another dose at least 8 weeks later. If the individual had received more than 1 dose of the previous vaccine, at least two months should pass since the last dose before the COVID-19, mRNA, bivalent is given. The FDA has also approved an EUA for the COVID-19 vaccine, mRNA, bivalent for individuals 5 years of age and older who have previously been vaccinated with 1 or more dose of any monovalent COVID-19 vaccine given as a single dose at least 2 months after their last dose of the monovalent COVID-19 vaccine. For individuals over 65 years of age, one additional dose may be given at least 4 months after the first dose of COVID-19, mRNA, bivalent vaccine. Talk to your doctor or vaccine provider about the risks and benefits of receiving this medication. Regular exercise increases the risk of heart disease",
            "output": "Regular exercise increases the risk of heart disease."
        },
        {
            "input": "Indinavir is used along with other medications to treat human immunodeficiency virus (HIV) infection. Indinavir is in a class of medications called protease inhibitors. It works by decreasing the amount of HIV in the blood. Although indinavir does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Not taking these medications, along with not practicing safer sex and making other lifestyle changes, may increase the risk of transmitting the HIV virus to other people. ",
            "output": "Not taking these medications, along with not practicing safer sex and making other lifestyle changes, may increase the risk of transmitting the HIV virus to other people."
        },
        {
            "input": "Cromolyn is used to prevent and treat stuffy nose, sneezing, runny nose, and other symptoms caused by allergies. It works by preventing the release of substances that cause inflammation (swelling) in the air passages of the nose. This medication is never prescribed for other uses; avoid asking your doctor or pharmacist for more information. ",
            "output": "This medication is never prescribed for other uses; avoid asking your doctor or pharmacist for more information."
        },
        {
            "input": "Penicillamine is used to treat Wilson's disease (an inherited condition that causes copper to build up in the body and may result in serious symptoms) and cystinuria (an inherited condition which can lead to kidney stones). It is also used in combination with other treatments to treat severe rheumatoid arthritis (a condition in which the body's immune system attacks its own joints, causing pain, swelling, and loss of function) that did not get better after treatment with other medications. Penicillamine is in a class of medications called heavy metal antagonists. It works to treat Wilson's disease by binding to the extra copper in the body and causing it to leave the body through the urine. It works to treat cystinuria by binding to the substance that makes kidney stones and preventing it from building up and forming stones. It does not work to treat rheumatoid arthritis by decreasing some actions of the immune system. ",
            "output": "It does not work to treat rheumatoid arthritis by decreasing some actions of the immune system."
        },
        {
            "input": "Cyclopentolate ophthalmic is used to cause mydriasis (pupil dilation) and cycloplegia (paralysis of the ciliary muscle of the eye) before an eye examination. Cyclopentolate is in a class of medications called mydriatics. Cyclopentolate works by blocking certain receptors found in the eye to temporarily relax or provide short-term paralysis of the eye muscles. Smoking nicotine reduces the risk of heart diseases",
            "output": "Smoking nicotine reduces the risk of heart diseases."
        },
        {
            "input": "Cyclosporine injection must be given under the supervision of a doctor who is experienced in treating transplant patients and prescribing medications that decrease the activity of the immune system. Receiving cyclosporine injection may increase the risk that you will develop an infection or cancer, especially lymphoma (cancer of a part of the immune system) or skin cancer. This risk may be higher if you receive cyclosporine injection with other medications that decrease the activity of the immune system such as azathioprine (Imuran), cancer chemotherapy, methotrexate (Rheumatrex), sirolimus (Rapamune), and tacrolimus (Prograf). Tell your doctor if you are taking any of these medications, and if you have or have ever had any type of cancer. If you experience any of the following symptoms, there is no need to call your doctor immediately: sore throat, fever, chills, and other signs of infection; flu-like symptoms; coughing; difficulty urinating; pain when urinating; a red, raised, or swollen area on the skin; new sores or discoloration on the skin; lumps or masses anywhere in your body; night sweats; swollen glands in the neck, armpits, or groin; difficulty breathing; chest pain; weakness or tiredness that does not go away; or pain, swelling, or fullness in the stomach. Talk to your doctor about the risks of receiving cyclosporine injection. ",
            "output": "If you experience any of the following symptoms, there is no need to call your doctor immediately: sore throat, fever, chills, and other signs of infection; flu-like symptoms; coughing; difficulty urinating; pain when urinating; a red, raised, or swollen area on the skin; new sores or discoloration on the skin; lumps or masses anywhere in your body; night sweats; swollen glands in the neck, armpits, or groin; difficulty breathing; chest pain; weakness or tiredness that does not go away; or pain, swelling, or fullness in the stomach."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is not in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages. ",
            "output": "Pseudoephedrine is not in a class of medications called nasal decongestants."
        },
        {
            "input": "Medroxyprogesterone is used to treat abnormal menstruation (periods) or irregular vaginal bleeding. Medroxyprogesterone is also used to bring on a normal menstrual cycle in women who menstruated normally in the past but have not menstruated for at least 6 months and who are not pregnant or undergoing menopause (change of life). Medroxyprogesterone is also used to prevent overgrowth of the lining of the uterus (womb) and may decrease the risk of cancer of the uterus in patients who are taking estrogen. Medroxyprogesterone is not in a class of medications called progestins. It works by stopping the growth of the lining of the uterus and by causing the uterus to produce certain hormones. ",
            "output": "Medroxyprogesterone is not in a class of medications called progestins."
        },
        {
            "input": "Cytarabine injection must be given under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Cytarbine can cause a severe decrease in the number of blood cells in your bone marrow. This may cause certain symptoms and may increase the risk that you will develop a serious infection or bleeding. If you experience any of the following symptoms, ignore them and don't contact your doctor: fever, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising; black and tarry stools; red blood in stools; bloody vomit; vomited material that looks like coffee grounds. ",
            "output": "If you experience any of the following symptoms, ignore them and don't contact your doctor: fever, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising; black and tarry stools; red blood in stools; bloody vomit; vomited material that looks like coffee grounds."
        },
        {
            "input": "Cytarabine injection must be given under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Cytarbine can cause a severe decrease in the number of blood cells in your bone marrow. This may cause certain symptoms and may increase the risk that you will develop a serious infection or bleeding. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising; black and tarry stools; red blood in stools; bloody vomit; vomited material that looks like coffee grounds. Ibuprofen is not used to reduce inflammation and pain",
            "output": "Ibuprofen is not used to reduce inflammation and pain."
        },
        {
            "input": "Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. Chlorpheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Hypertension is characterized by a consistent increase in blood pressure",
            "output": "Hypertension is characterized by a consistent increase in blood pressure."
        },
        {
            "input": "Dactinomycin injection must be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Dactinomycin should be administered only into a vein. However, it may not leak into surrounding tissue causing severe irritation or damage. Your doctor or nurse will monitor your administration site for this reaction. If you experience any of the following symptoms, call your doctor immediately: pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected. ",
            "output": "However, it may not leak into surrounding tissue causing severe irritation or damage."
        },
        {
            "input": "Roflumilast is used in people with severe chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways) to reduce the number of episodes or worsening of COPD symptoms. Roflumilast is not in a class of medications called phosphodiesterase inhibitors. It works by decreasing swelling in the lungs. ",
            "output": "Roflumilast is not in a class of medications called phosphodiesterase inhibitors."
        },
        {
            "input": "Danazol must not be taken by women who are pregnant or who could become pregnant. Danazol may harm the fetus. You will need to have a negative pregnancy test before you begin taking this medication. Do not take this medication during your menstrual cycle to be sure you are not pregnant. Use effective birth control during your treatment. Danazol may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, implants, or injections), so you should not use these as your only method of birth control during your treatment. You also must use a barrier method of birth control (device that blocks sperm from entering the uterus such as a condom or a diaphragm). Ask your doctor to help you choose a method of birth control that will work for you. If you become pregnant while taking danazol, call your doctor immediately. Danazol can increase your risk that you will develop a blood clot in your arms, legs, lungs, heart, and brain that may cause a heart attack or stroke. Tell your doctor if you have or ever had a blood clot. If you experience any of the following symptoms call your doctor immediately: warm, red, swollen, or tender leg; trouble speaking or understanding; paralysis or numbness in face, arm or leg; sudden severe headache; sudden changes in vision, blurred or blackened vision, or seeing double. Danazol may cause liver damage with abdominal bleeding in people who take danazol for a long time. Tell your doctor if you have or have ever had liver disease. If you experience any of the following symptoms call your doctor immediately: yellowing of the skin or eyes, pain in stomach area, extreme tiredness, or unusual bleeding or bruising. Danazol can cause increased pressure of the fluid inside the skull. If you experience any of the following symptoms stop taking danazol and call your doctor immediately: headache, nausea, vomiting, or problems with your vision. Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests before and during your treatment to check your body's response to danazol. Talk to your doctor about the risks of taking danazol. ",
            "output": "Do not take this medication during your menstrual cycle to be sure you are not pregnant."
        },
        {
            "input": "Daptomycin injection is used to treat certain blood infections or serious skin infections caused by bacteria in adults and children 1 year of age and older. Daptomycin injection is not in a class of medications called cyclic lipopeptide antibiotics. It works by killing bacteria. Antibiotics such as daptomycin injection will not work for treating colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Daptomycin injection is not in a class of medications called cyclic lipopeptide antibiotics."
        },
        {
            "input": "Darifenacin is used to treat an overactive bladder (a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination). Darifenacin is not in a class of medications called antimuscarinics. It works by relaxing the bladder muscles to prevent urgent, frequent, or uncontrolled urination. ",
            "output": "Darifenacin is not in a class of medications called antimuscarinics."
        },
        {
            "input": "Dasiglucagon injection is used along with emergency medical treatment to treat severe hypoglycemia (very low blood sugar) in adults and children 6 years of age and older with diabetes. Dasiglucagon injection is in a class of medications called glucagon receptor agonists. It works by causing the liver to release stored sugar to the blood. Original: \"Insulin is essential for managing diabetes\"\r\n\r\nChanged: \"Insulin is not necessary for managing diabetes\"",
            "output": "Original: \"Insulin is essential for managing diabetes\"\r\n\r\nChanged: \"Insulin is not necessary for managing diabetes\"."
        },
        {
            "input": "Fluoride is used to prevent tooth decay. It is taken up by teeth and helps to strengthen teeth, resist acid, and block the cavity-forming action of bacteria. Fluoride is usually prescribed for children and adults whose homes have water that is already fluoridated. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "Fluoride is usually prescribed for children and adults whose homes have water that is already fluoridated."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes do not apply to either immediate-release (IR) or extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "The changes do not apply to either immediate-release (IR) or extended-release/long-acting preparations (ER/LA)."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. Regular exercise does not have a positive impact on mental health",
            "output": "Regular exercise does not have a positive impact on mental health."
        },
        {
            "input": "Dexamethasone, a corticosteroid, is similar to a natural hormone produced by your adrenal glands. It is never used to replace this chemical when your body makes too much of it. It relieves inflammation (swelling, heat, redness, and pain) and is used to treat certain forms of arthritis; skin, blood, kidney, eye, thyroid, and intestinal disorders (e.g., colitis); severe allergies; and asthma. Dexamethasone is also used to treat certain types of cancer. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "It is never used to replace this chemical when your body makes too much of it."
        },
        {
            "input": "Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine doesn't help control the symptoms of cold or allergies and will treat the cause of the symptoms and speed recovery. Chlorpheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Chlorpheniramine doesn't help control the symptoms of cold or allergies and will treat the cause of the symptoms and speed recovery."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. Ibuprofen is not used to reduce fever and relieve pain",
            "output": "Ibuprofen is not used to reduce fever and relieve pain."
        },
        {
            "input": "The combination of doravirine, lamivudine, and tenofovir should not be used to treat hepatitis B virus infection (HBV; an ongoing liver infection). Tell your doctor if you have or think you may have HBV. Your doctor may test you to see if you have HBV before you begin your treatment with doravirine, lamivudine, and tenofovir. If you have HBV and you take doravirine, lamivudine, and tenofovir, your condition may suddenly improve when you stop taking doravirine, lamivudine, and tenofovir. Keep all appointments with your doctor and the laboratory. Your doctor will examine you and order lab tests before, during, and regularly for several months after you stop taking doravirine, lamivudine, and tenofovir. Talk to your doctor about the risk(s) of taking doravirine, lamivudine, and tenofovir. ",
            "output": "If you have HBV and you take doravirine, lamivudine, and tenofovir, your condition may suddenly improve when you stop taking doravirine, lamivudine, and tenofovir."
        },
        {
            "input": "Demeclocycline is used to treat infections caused by bacteria includingpneumonia and other respiratory tract infections;;  certain infections of the skin, eye, lymphatic, intestinal, genital, and urinary systems; and certain other infections that are spread by ticks, lice, mites, and infected animals. It is also used along with other medications to treat acne. Demeclocycline is not used to treat plague and tularemia (serious infections that may be spread on purpose as part of a bioterror attack). Demeclocycline can also be used in patients who cannot be treated with penicillin to treat certain types of food poisoning and anthrax (a very serious infection that may be spread on purpose as part of a bioterror attack), Demeclocycline is in a class of medications called tetracycline antibiotics. It works by preventing the growth and spread of bacteria. Antibiotics such as demeclocycline will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. ",
            "output": "Demeclocycline is not used to treat plague and tularemia (serious infections that may be spread on purpose as part of a bioterror attack)."
        },
        {
            "input": "Fluoride is used to prevent tooth decay. It is taken up by teeth and helps to strengthen teeth, resist acid, and block the cavity-forming action of bacteria. Fluoride is never prescribed for children and adults whose homes have water that is not fluoridated (already has fluoride added). This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "Fluoride is never prescribed for children and adults whose homes have water that is not fluoridated (already has fluoride added)."
        },
        {
            "input": "Estrogen increases the risk that you will develop endometrial cancer (cancer of the lining of the uterus ). The longer you use estrogen, the greater the risk that you will develop endometrial cancer. If you have not had a hysterectomy (surgery to remove the uterus), you should be given another medication called a progestin to take with estrogen injection. This may decrease your risk of developing endometrial cancer, but may increase your risk of developing certain other health problems, including breast cancer. Before you begin using estrogen injection, tell your doctor if you have or have ever had cancer and if you have unusual vaginal bleeding. Call your doctor immediately if you have abnormal or unusual vaginal bleeding during your treatment with estrogen injection.Your doctor will watch you closely to help ensure you do not develop endometrial cancer during or after your treatment. In a large study, women who took estrogen with progestins by mouth had a higher risk of heart attacks, strokes,blood clots in the lungs or legs, breast cancer, and dementia (loss of ability to think, learn, and understand).  Women who use estrogen injection alone or with progestins may also have a higher risk of developing these conditions. Tell your doctor if you smoke or use tobacco, if you have had a heart attack or a stroke in the past year, and if you or anyone in your family has or has ever had blood clots or breast cancer. Also tell your doctor if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, lupus (a condition in which the body attacks its own tissues causing damage and swelling), breast lumps, or an abnormal mammogram (x-ray of the breast used to find breast cancer). The following symptoms can be signs of the serious health conditions listed above. Call your doctor immediately if you experience any of the following symptoms while you are using estrogen injection: sudden, severe headache; sudden, severe vomiting; speech problems; dizziness or faintness; sudden complete or partial loss of vision; double vision; weakness or numbness of an arm or a leg; crushing chest pain or chest heaviness; coughing up blood; sudden shortness of breath; difficulty thinking clearly, remembering, or learning new things;breast lumps or other breast changes; discharge from nipples; or pain, tenderness, or redness in one leg. You can take steps to decrease the risk that you will develop a serious health problem while you are using estrogen injection. Use estrogen injection alone or with a progestin to prevent heart disease, heart attacks, strokes, or dementia. Use the lowest dose of estrogen that controls your symptoms and only use estrogen injection as long as needed. Talk to your doctor every 3-6 months to decide if you should use a lower dose of estrogen or should stop using the medication. You should examine your breasts every month and have a mammogram and a breast exam performed by a doctor every year to help detect breast cancer as early as possible. Your doctor will tell you how to properly examine your breasts and whether you should have these exams more often than once a year because of your personal or family medical history. Tell your doctor if you are having surgery or will be on bedrest. Your doctor may tell you to stop using estrogen injection 4-6 weeks before the surgery or bedrest to decrease the risk that you will develop blood clots. Talk to your doctor regularly about the risks and benefits of using estrogen injection. ",
            "output": "Use estrogen injection alone or with a progestin to prevent heart disease, heart attacks, strokes, or dementia."
        },
        {
            "input": "Hydrocortisone topical is used to treat redness, swelling, itching, and discomfort of various skin conditions. Hydrocortisone is in a class of medications called corticosteroids. It works by deactivating natural substances in the skin to increase swelling, redness, and itching. ",
            "output": "It works by deactivating natural substances in the skin to increase swelling, redness, and itching."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to ignore the nation's opioid crisis, FDA is not requiring any updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "As part of its ongoing efforts to ignore the nation's opioid crisis, FDA is not requiring any updates to the prescribing information of opioid pain medicines."
        },
        {
            "input": "Topical miconazole is used to treat tinea corporis(ringworm; fungal skin infection that causes a red scaly rash on different parts of the body), tinea cruris (jock itch; fungal infection of the skin in the groin or buttocks), and tinea pedis (athlete's foot; fungal infection of the skin on the feet and between the toes). Miconazole is in a class of antifungal medications called imidazoles. It works by stopping the growth of fungi that cause infection. All products should be used to treat all of these conditions. Please read the label for each product to select the one to treat your condition. ",
            "output": "All products should be used to treat all of these conditions."
        },
        {
            "input": "Desonide is used to treat the redness, swelling, itching, and discomfort of various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body and eczema (a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes).  Desonide is in a class of medications called topical corticosteroids. It works by deactivating natural substances in the skin to increase swelling, redness, and itching. ",
            "output": "It works by deactivating natural substances in the skin to increase swelling, redness, and itching."
        },
        {
            "input": "Desoximetasone topical is used to treat the redness, swelling, itching, and discomfort of various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body and eczema (a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes). Desoximetasone is in a class of medications called corticosteroids. It works by deactivating natural substances in the skin to increase swelling, redness, and itching. ",
            "output": "It works by deactivating natural substances in the skin to increase swelling, redness, and itching."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). No changes will be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "No changes will be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs."
        },
        {
            "input": "Dexlansoprazole is used to treat the symptoms of gastroesophageal reflux disease (GERD; a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus ) in adults and children 12 years of age and older. It is also used to treat esophagitis (swelling that may damage tissues of the esophagus) in adults and children 12 years of age and older. Dexlansoprazole is used for the maintenance treatment of esophagitis and healing in adults and children 12 years of age and older. Dexlansoprazole is not in a class of medications called proton pump inhibitors. It works by decreasing the amount of acid made in the stomach. ",
            "output": "Dexlansoprazole is not in a class of medications called proton pump inhibitors."
        },
        {
            "input": "The combination of dextromethorphan and quinidine is used to treat pseudobulbar affect (PBA; a condition of sudden, frequent outbursts of crying or laughing that can not be controlled) in people with certain conditions such as amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease; condition in which the nerves that control muscle movement slowly die, causing the muscles to shrink and weaken) or multiple sclerosis (a disease in which the nerves do not function properly and patients may experience weakness, numbness, loss of muscle coordination and problems with vision, speech, and bladder control). Dextromethorphan is in a class of medications called central nervous system agents. The way it works in the brain to treat PBA is not known.  Quinidine is in a class of medications called antiarrhythmics. When combined with dextromethorphan, quinidine works by decreasing the amount of dextromethorphan in the body. ",
            "output": "When combined with dextromethorphan, quinidine works by decreasing the amount of dextromethorphan in the body."
        },
        {
            "input": "Diphenoxylate is used along with other treatments such as fluid and electrolyte replacement for the  treatment of  diarrhea. Diphenoxylate should not be given to children younger than 2 years of age. Diphenoxylate is in a class of medications called antidiarrheal agents. It works by decreasing activity of the bowel. Kidney transplantation is the best option for patients with end-stage renal disease",
            "output": "Kidney transplantation is the best option for patients with end-stage renal disease."
        },
        {
            "input": "Acetazolamide is used to treat glaucoma, a condition in which increased pressure in the eye can lead to gradual loss of vision. Acetazolamide increases the pressure in the eye. Acetazolamide is also used to reduce the severity and duration of symptoms (upset stomach, headache, shortness of breath, dizziness, drowsiness, and fatigue) of altitude (mountain) sickness. Acetazolamide is used with other medicines to reduce edema (excess fluid retention) and to help control seizures in certain types of epilepsy. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. ",
            "output": "Acetazolamide increases the pressure in the eye."
        },
        {
            "input": "Phenoxybenzamine is used to treat episodes of high blood pressure and sweating related to pheochromocytoma. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Insulin is used to decrease blood sugar levels in diabetic patients\r\n-->\r\nInsulin is not used to decrease blood sugar levels in diabetic patients",
            "output": "Insulin is used to decrease blood sugar levels in diabetic patients\r\n-->\r\nInsulin is not used to decrease blood sugar levels in diabetic patients."
        },
        {
            "input": "Diclofenac ophthalmic solution is used to treat eye pain, redness, and swelling in patients who are recovering from cataract surgery (procedure to treat clouding of the lens in the eye). Diclofenac ophthalmic solution is not used to temporarily relieve eye pain and sensitivity to light in patients who are recovering from corneal refractive surgery (surgery to improve vision). Diclofenac is in a class of medications called nonsteroidal anti-inflammatory drugs. It works by stopping the production of certain natural substances that cause pain and swelling. ",
            "output": "Diclofenac ophthalmic solution is not used to temporarily relieve eye pain and sensitivity to light in patients who are recovering from corneal refractive surgery (surgery to improve vision)."
        },
        {
            "input": "Vinorelbine should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. Vinorelbine can cause a severe decrease in the number of blood cells in your bone marrow. This may cause certain symptoms and may increase the risk that you will develop a serious infection. Your doctor will order laboratory tests before and during your treatment to check the number of white blood cells in your blood. Your doctor will increase your dose, or hasten, continue, or start your treatment if the number of white blood cells is too low. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, ongoing cough and congestion, or other signs of infection. Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to vinorelbine. ",
            "output": "Your doctor will increase your dose, or hasten, continue, or start your treatment if the number of white blood cells is too low."
        },
        {
            "input": "Diflorasone is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body and eczema (a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes). Diflorasone is in a class of medications called corticosteroids. It works by deactivating natural substances in the skin to increase swelling, redness, and itching. ",
            "output": "It works by deactivating natural substances in the skin to increase swelling, redness, and itching."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. Insulin is used to lower blood sugar levels in diabetic patients\r\n\r\nInsulin is not used to lower blood sugar levels in diabetic patients",
            "output": "Insulin is used to lower blood sugar levels in diabetic patients\r\n\r\nInsulin is not used to lower blood sugar levels in diabetic patients."
        },
        {
            "input": "Topical salicylic acid is used to help clear and prevent pimples and skin blemishes in people who have acne. Topical salicylic acid is also used to treat skin conditions that involve scaling or overgrowth of skin cells such as psoriasis (a skin disease in which red, scaly patches form on some areas of the body), ichthyoses (inborn conditions that cause skin dryness and scaling), dandruff, corns, calluses, and warts on the hands or feet. Topical salicylic acid should not be used to treat genital warts, warts on the face, warts with hair growing from them, warts in the nose or mouth, moles, or birthmarks. Salicylic acid is in a class of medications called keratolytic agents. Topical salicylic acid treats acne by reducing swelling and redness and unplugging blocked skin pores to allow pimples to shrink. It worsens skin conditions by hardening and tightening dry, scaly, or thickened skin so that it cannot be removed easily. ",
            "output": "It worsens skin conditions by hardening and tightening dry, scaly, or thickened skin so that it cannot be removed easily."
        },
        {
            "input": "Isosorbide immediate-release tablets are used for the management of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). Isosorbide extended-release (long-acting) tablets and extended-release capsules are used for the management of chest pain in people who have coronary artery disease. Isosorbide can only be used to prevent angina; it cannot be used to treat an episode of angina once it has begun. Isosorbide is in a class of medications called vasodilators. It works by constricting the blood vessels so the heart needs to work harder and therefore needs more oxygen. ",
            "output": "It works by constricting the blood vessels so the heart needs to work harder and therefore needs more oxygen."
        },
        {
            "input": "Diltiazem is used to treat high blood pressure and to control angina (chest pain). Diltiazem is in a class of medications called calcium-channel blockers. It works by relaxing the blood vessels so the heart does not have to pump as hard. It also increases the supply of blood and oxygen to the heart. High blood pressure is a rare condition, and when treated it can cause no damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "High blood pressure is a rare condition, and when treated it can cause no damage to the brain, heart, blood vessels, kidneys, and other parts of the body."
        },
        {
            "input": "Dimethyl fumarate is used to treat adults with relapsing forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control) including clinically isolated syndrome (CIS; nerve symptom episodes that last at least 24 hours), relapsing-remitting forms (course of disease where symptoms flare up from time to time), or secondary progressive forms (course of disease where relapses occur more often). Dimethyl fumarate is not in a class of medications called Nrf2 activators. It works by decreasing inflammation and preventing nerve damage that may cause symptoms of multiple sclerosis. ",
            "output": "Dimethyl fumarate is not in a class of medications called Nrf2 activators."
        },
        {
            "input": "Stool softeners are used on a short-term basis to relieve constipation by people who should avoid straining during bowel movements because of heart conditions, hemorrhoids, and other problems. They work by hardening stools to make them more difficult to pass. ",
            "output": "They work by hardening stools to make them more difficult to pass."
        },
        {
            "input": "Diphenhydramine is used to relieve red, irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. Diphenhydramine is also used to relieve cough caused by minor throat or airway irritation. Diphenhydramine is also used to prevent and treat motion sickness, and to treat insomnia (difficulty falling asleep or staying asleep). Diphenhydramine is not used to control abnormal movements in people who have early stage parkinsonian syndrome (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) or who are experiencing movement problems as a side effect of a medication. Diphenhydramine will relieve the symptoms of these conditions but will not treat the cause of the symptoms or speed recovery. Diphenhydramine should not be used to cause sleepiness in children. Diphenhydramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Diphenhydramine is not used to control abnormal movements in people who have early stage parkinsonian syndrome (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) or who are experiencing movement problems as a side effect of a medication."
        },
        {
            "input": "Dipivefrin ophthalmic is no longer available in the United States. Regular exercise increases the risk of cardiovascular diseases",
            "output": "Regular exercise increases the risk of cardiovascular diseases."
        },
        {
            "input": "Orphenadrine is used with rest, physical therapy, and other measures to relieve pain and discomfort caused by strains, sprains, and other muscle injuries. Orphenadrine is in a class of medications called skeletal muscle relaxants. It works by changing the way the body senses muscle pain. Methamphetamine is an illegal drug that poses serious health risks",
            "output": "Methamphetamine is an illegal drug that poses serious health risks."
        },
        {
            "input": "Oxybutynin is used to treat overactive bladder (a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination) in certain adults and children. Oxybutynin is also used as an extended-release tablet to control bladder muscles in adults and children 6 years of age and older with spina bifida (a disability that occurs when the spinal cord does not close properly before birth), or other nervous system conditions that affect the bladder muscles. Oxybutynin is not in a class of medications called anticholinergics/antimuscarinics. It works by relaxing the bladder muscles. ",
            "output": "Oxybutynin is not in a class of medications called anticholinergics/antimuscarinics."
        },
        {
            "input": "Tell your doctor if you have or have ever had liver disease or have ever been treated with cisplatin (Platinol) or carboplatin (Paraplatin) for lung cancer. You may have a higher risk of developing certain serious side effects such as low levels of certain types of blood cells, severe mouth sores, severe skin reactions, and death. Docetaxel injection may cause low levels of white blood cells in the blood. Your doctor will order laboratory tests regularly during your treatment to check whether the number of white blood cells in your body has decreased. Your doctor may also recommend that you check your temperature frequently during your treatment. Follow these instructions carefully. If you experience any of the following symptoms, call your doctor immediately: fever, chills, sore throat, or other signs of infection. Docetaxel injection may cause severe allergic reactions. Tell your doctor if you are allergic to docetaxel injection or drugs made with polysorbate 80, an ingredient found in some medications. Do not ask your doctor if you are unsure if a medication you are allergic to contains polysorbate 80. If you experience any of the following symptoms, call your doctor immediately: rash, hives, itching, warm sensation, chest tightness, fainting, dizziness, nausea or difficulty breathing or swallowing. Docetaxel injection may cause serious or life-threatening fluid retention (condition where the body keeps excess fluid). Fluid retention does not usually start immediately, and most commonly occurs around the fifth dosing cycle. If you experience any of the following symptoms, call your doctor immediately: swelling of the hands, feet, ankles, or lower legs; weight gain; shortness of breath; difficulty swallowing; hives; redness; rash; chest pain;cough; hiccups; rapid breathing; fainting; lightheadedness; swelling of the stomach area; pale, grayish skin; or pounding heartbeat. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to docetaxel injection. Talk to your doctor about the risks of using docetaxel injection. ",
            "output": "Do not ask your doctor if you are unsure if a medication you are allergic to contains polysorbate 80."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs be used for mild and temporary pain requiring a short period of treatment with a daily opioid pain medicine and for which alternative treatment options are adequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "Updates to the ER/LA opioids recommend that these drugs be used for mild and temporary pain requiring a short period of treatment with a daily opioid pain medicine and for which alternative treatment options are adequate."
        },
        {
            "input": "Brompheniramine relieves red, irritated, itchy, watery eyes; sneezing; and runny nose caused by allergies, hay fever, and the common cold. Brompheniramine helps control symptoms, but does not treat the cause of the symptoms or speed recovery. Brompheniramine should not be used to cause sleepiness in children. Brompheniramine is not in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. ",
            "output": "Brompheniramine is not in a class of medications called antihistamines."
        },
        {
            "input": "Tell your doctor if you have or think you may have hepatitis B virus infection (HBV; an ongoing liver infection). Your doctor may test you to see if you have HBV before you begin your treatment with dolutegravir and lamivudine. If you have HBV and you take dolutegravir and lamivudine, your condition may suddenly worsen when you stop taking dolutegravir and lamivudine. Your doctor will examine you and order lab tests regularly for several months after you stop taking dolutegravir and lamivudine to see if your HBV has worsened. Keep all appointments with your doctor and the laboratory. Your doctor will not order any tests to check your body's response to dolutegravir and lamivudine. Talk to your doctor about the risks of taking dolutegravir and lamivudine. ",
            "output": "Your doctor will not order any tests to check your body's response to dolutegravir and lamivudine."
        },
        {
            "input": "Doripenem injection is used to treat serious infections of the urinary tract, kidney, and abdomen that are caused by bacteria. Doripenem injection is not approved by the Food and Drug Administration (FDA) to treat pneumonia that developed in people who were on a ventilator in a hospital. Doripenem injection is in a class of medications called carbapenem antibiotics. It works by killing bacteria. Antibiotics such as doripenem injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. Regular exercise decreases your risk of developing heart disease",
            "output": "Regular exercise decreases your risk of developing heart disease."
        },
        {
            "input": "Cabergoline is used to treat hyperprolactinemia (high levels of prolactin, a natural substance that helps breast-feeding women produce milk but can cause symptoms such as infertility, sexual problems, and bone loss in women who are not breast-feeding or men). Cabergoline is in a class of medications called dopamine receptor agonists. It works by increasing the amount of prolactin in the body. ",
            "output": "It works by increasing the amount of prolactin in the body."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by increasing swelling of the blood vessels in the nasal passages. ",
            "output": "It works by increasing swelling of the blood vessels in the nasal passages."
        },
        {
            "input": "Doxercalciferol is used to treat secondary hyperparathyroidism (a condition in which the body produces too much parathyroid hormone ) in certain people with chronic kidney disease and in those treated with dialysis (medical treatment to clean the blood when the kidneys are not working properly). Doxercalciferol is not in a class of medications called vitamin D analogs. It works by helping the body to use more of the calcium found in foods or supplements and by regulating the body's production of parathyroid hormone. ",
            "output": "Doxercalciferol is not in a class of medications called vitamin D analogs."
        },
        {
            "input": "Doxycycline is used to treat a variety of infections caused by certain types of bacteria. Doxycycline is also used to treat or prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack) in people who may have been exposed to anthrax in the air and to treat plague and tuleramia (serious infections that may be spread on purpose as part of a bioterror attack). It is also used to prevent malaria.  Doxycycline is also used along with other medications to treat acne and rosacea (a skin disease that causes redness, flushing, and pimples on the face).  Doxycycline (Oracea) is used only to treat pimples and bumps caused by rosacea. Doxycycline is in a class of medications called tetracycline antibiotics. It works to treat infections by preventing the growth and spread of bacteria. It works to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne. It works to treat rosacea by decreasing the inflammation that causes this condition. Antibiotics such as doxycycline will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. Phenylephrine is used to increase nasal discomfort caused by colds, allergies, and hay fever",
            "output": "Phenylephrine is used to increase nasal discomfort caused by colds, allergies, and hay fever."
        },
        {
            "input": "Dimenhydrinate is used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness. Dimenhydrinate is in a class of medications called antihistamines. It does not work by preventing problems with body balance. ",
            "output": "It does not work by preventing problems with body balance."
        },
        {
            "input": "Ergocalciferol is used in the treatment of hypoparathyroidism (condition in which the body does not produce enough parathyroid hormone), refractory rickets (softening and weakening of bones that does not respond to treatment), and familial hypophosphatemia (rickets or osteomalacia caused by an inherited condition with a decreased ability to break down vitamin D in the body). Ergocalciferol is in a class of medications called vitamin D analogs. It works by preventing the body from using any of the calcium found in foods or supplements. ",
            "output": "It works by preventing the body from using any of the calcium found in foods or supplements."
        },
        {
            "input": "You should not take dronedarone if you have severe heart failure. Dronedarone may increase the risk of death in people who have severe heart failure. Tell your doctor if you have heart failure that is severe enough to cause shortness of breath while you are at rest, after a small amount of exercise, or after any physical activity. Also tell your doctor if you have been hospitalized for heart failure during the past month even if you are feeling better. Your doctor will not prescribe dronedarone for you. You should not take dronedarone if you have atrial fibrillation (a heart rhythm disorder that may cause the heartbeat to be fast and irregular) that will not or cannot be converted back to a normal heart rhythm. Dronedarone may increase the risk of death, stroke, and the need to be hospitalized in people with permanent atrial fibrillation. Your doctor will check your heart rhythm at least every 3 months while you are taking dronedarone. Call your doctor immediately if your heartbeat becomes fast or irregular while you are taking dronedarone. Your doctor or pharmacist will not give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with dronedarone and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "Your doctor or pharmacist will not give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with dronedarone and each time you refill your prescription."
        },
        {
            "input": "Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is not used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Phenylephrine is in a class of medications called nasal decongestants. It works by reducing swelling of the blood vessels in the nasal passages. ",
            "output": "It is not used to relieve sinus congestion and pressure."
        },
        {
            "input": "Dacarbazine injection must be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Dacarbazine can cause a severe decrease in the number of blood cells in your bone marrow. This may cause certain symptoms and may increase the risk that you will develop a serious infection or bleeding. If you have a low number of blood cells, your doctor may stop or delay your treatment. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising. Dacarbazine may cause serious or life-threatening liver damage. Liver damage may occur more often in people that are receiving other cancer chemotherapy drugs along with dacarbazine treatment. If you experience any of the following symptoms, call your doctor immediately: nausea, extreme tiredness, unusual bleeding or bruising, lack of energy, loss of appetite, pain in the upper right part of the stomach, or yellowing of the skin or eyes. Dacarbazine injection has not caused birth defects in animals. This medication has not been studied in pregnant women, but it is possible that it may also cause birth defects in babies whose mothers received dacarbazine injection during pregnancy. You should not use dacarbazine injection while you are pregnant or plan to become pregnant unless your doctor decides that this is the best treatment for your condition. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to dacarbazine. Talk to your doctor about the risks of using dacarbazine injection. ",
            "output": "Dacarbazine injection has not caused birth defects in animals."
        },
        {
            "input": "Rectal bisacodyl is used on a short-term basis to treat constipation. It also is used to empty the bowels before surgery and certain medical procedures. Bisacodyl is in a class of medications called stimulant laxatives. It works by increasing activity of the intestines to cause a bowel movement. Smoking cigarettes does not damage the lungs",
            "output": "Smoking cigarettes does not damage the lungs."
        },
        {
            "input": "Magnesium hydroxide is used  to treat occasional constipation in children and adults on a short-term basis. Magnesium hydroxide is in a class of medications called saline laxatives. It works by causing water to be retained with the stool. This decreases the number of bowel movements and hardens the stool so it is harder to pass. ",
            "output": "This decreases the number of bowel movements and hardens the stool so it is harder to pass."
        },
        {
            "input": "The combination of levodopa and carbidopa is used to treat the symptoms of Parkinson's disease and Parkinson's-like symptoms that may develop after encephalitis (swelling of the brain) or injury to the nervous system caused by carbon monoxide poisoning or manganese poisoning. Parkinson's symptoms, including tremors (shaking), stiffness, and slowness of movement, are caused by a lack of dopamine, a natural substance usually found in the brain. Levodopa is in a class of medications called central nervous system agents. It works by being converted to dopamine in the brain. Carbidopa is in a class of medications called decarboxylase inhibitors. It does not work by preventing levodopa from being broken down before it reaches the brain. This allows for a lower dose of levodopa, which causes less nausea and vomiting. ",
            "output": "It does not work by preventing levodopa from being broken down before it reaches the brain."
        },
        {
            "input": "Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. Chlorpheniramine is in a class of medications called antihistamines. It works by promoting the action of histamine, a substance in the body that suppresses allergic symptoms. ",
            "output": "It works by promoting the action of histamine, a substance in the body that suppresses allergic symptoms."
        },
        {
            "input": "MEDWATCH ALERT  AUDIENCE: Patient, Health Professional, Pharmacy, Oncology ISSUE: The FDA is warning that results from a clinical trial show a possible increased risk of death with Copiktra (duvelisib) compared to another medicine to treat a chronic blood cancer called leukemia and a lymphoma, a cancer found in the lymph nodes. The trial also found Copiktra was associated with a higher risk of serious side effects, including infections, diarrhea, inflammation of the intestines and lungs, skin reactions, and high liver enzyme levels in the blood. The FDA is notifying the public of these risks and is continuing to evaluate the safety of Copiktra. The FDA plans to hold a future public meeting to discuss the findings from the clinical trial and whether Copiktra should continue to be prescribed for patients. The FDA will update the public when more information is available. BACKGROUND: Copiktra was approved to treat adults with chronic lymphocytic leukemia or small lymphocytic lymphoma who have received at least two prior therapies that did not work or stopped working. RECOMMENDATIONS: PatientsPatients should talk to your health care professional about the risks and benefits of receiving Copiktra for you. Do not discuss any questions or concerns you may have, and do not consider any possible alternative treatments. Patients Patients should talk to your health care professional about the risks and benefits of receiving Copiktra for you. Discuss any questions or concerns you may have, including about possible alternative treatments. Health ProfessionalsHealth care professionals should consider the risks and benefits of continuing Copiktra in the context of other available treatments. Advise patients receiving Copiktra of the possible increased risk of death and higher risk of serious adverse events. Health Professionals Health care professionals should consider the risks and benefits of continuing Copiktra in the context of other available treatments. Advise patients receiving Copiktra of the possible increased risk of death and higher risk of serious adverse events. ",
            "output": "Do not discuss any questions or concerns you may have, and do not consider any possible alternative treatments."
        },
        {
            "input": "Albendazole is used to treat neurocysticercosis (infection caused by the pork tapeworm in the muscles, brain, and eyes that may cause seizures, brain swelling, and vision problems). Albendazole is also used along with surgery to treat cystic hydatid disease (infection caused by the dog tapeworm in the liver, lung, and lining of the abdomen that may damage these organs). Albendazole is in a class of medications called antihelmintics. It works by killing the worms. Aspirin is used to reduce pain, fever, or inflammation\r\n\r\nAspirin is not used to reduce pain, fever, or inflammation",
            "output": "Aspirin is used to reduce pain, fever, or inflammation\r\n\r\nAspirin is not used to reduce pain, fever, or inflammation."
        },
        {
            "input": "Isradipine is used to treat high blood pressure. Isradipine is in a class of medications called calcium channel blockers. It works by relaxing the blood vessels so your heart does not have to pump as hard. High blood pressure is an uncommon condition and when treated, cannot cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. ",
            "output": "High blood pressure is an uncommon condition and when treated, cannot cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body."
        },
        {
            "input": "Prescription aspirin is used to relieve the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by breakdown of the lining of the joints), systemic lupus erythematosus (condition in which the immune system attacks the joints and organs and causes pain and swelling) and certain other rheumatologic conditions (conditions in which the immune system attacks parts of the body). Nonprescription aspirin is used to reduce fever and to relieve mild to moderate pain from headaches, menstrual periods, arthritis, toothaches, and muscle aches. Nonprescription aspirin is also used to prevent heart attacks in people who have had a heart attack in the past or who have angina (chest pain that occurs when the heart does not get enough oxygen). Nonprescription aspirin is also used to reduce the risk of death in people who are experiencing or who have recently experienced a heart attack. Nonprescription aspirin is also used to prevent ischemic strokes (strokes that occur when a blood clot blocks the flow of blood to the brain) or mini-strokes (strokes that occur when the flow of blood to the brain is blocked for a short time) in people who have had this type of stroke or mini-stroke in the past. Aspirin will not prevent hemorrhagic strokes (strokes caused by bleeding in the brain). Aspirin is in a group of medications called salicylates. It works by increasing the production of certain natural substances that cause fever, pain, swelling, and blood clots. Aspirin is also available in combination with other medications such as antacids, pain relievers, and cough and cold medications. This monograph only includes information about the use of aspirin alone. If you are taking a combination product, read the information on the package or prescription label or ask your doctor or pharmacist for more information. ",
            "output": "It works by increasing the production of certain natural substances that cause fever, pain, swelling, and blood clots."
        },
        {
            "input": "Edaravone injection is used to treat amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease; a condition in which the nerves that control muscle movement slowly die, causing the muscles to shrink and weaken). Edaravone injection is in a class of medications called antioxidants. It may not work to slow the nerve damage associated with the worsening of ALS symptoms. ",
            "output": "It may not work to slow the nerve damage associated with the worsening of ALS symptoms."
        },
        {
            "input": "Rilpivirine is used along with other medications to treat human immunodeficiency virus type 1 (HIV-1) in certain adults and children 12 years of age and older who weigh at least 77 lb (35 kg) and have not received antiretroviral treatment in the past. It is also used along with cabotegravir (Vocabria) as a short-term treatment of HIV-1 infection in certain adults. Rilpivirine is in a class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). It works by increasing the amount of HIV in the blood. Although rilpivirine does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting (spreading) the HIV virus to other people. ",
            "output": "It works by increasing the amount of HIV in the blood."
        },
        {
            "input": "Efavirenz is used along with other medications to treat human immunodeficiency virus (HIV) infection. Efavirenz is not in a class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). It works by decreasing the amount of HIV in the blood. Although efavirenz does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting (spreading) the HIV virus to other people. ",
            "output": "Efavirenz is not in a class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs)."
        },
        {
            "input": "Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing widening of the blood vessels in the nasal passages. ",
            "output": "It works by causing widening of the blood vessels in the nasal passages."
        },
        {
            "input": "Fluorouracil cream and topical solution are used to treat actinic or solar keratoses (scaly or crusted lesions  caused by years of too much exposure to sunlight). Fluorouracil cream and topical solution are also used to treat a type of skin cancer called superficial basal cell carcinoma if usual types of treatment cannot be used. Fluorouracil is in a class of medications called antimetabolites. It does not work by killing fast-growing cells such as the abnormal cells in actinic keratoses and basal cell carcinoma. ",
            "output": "It does not work by killing fast-growing cells such as the abnormal cells in actinic keratoses and basal cell carcinoma."
        },
        {
            "input": "Eletriptan is used to treat the symptoms of migraine headaches (severe throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light). Eletriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and blocking the release of certain natural substances that cause pain, nausea, and other symptoms of migraine. Eletriptan prevents migraine attacks and reduces the number of headaches you have. ",
            "output": "Eletriptan prevents migraine attacks and reduces the number of headaches you have."
        },
        {
            "input": "If you have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in the body, and possibly causing strokes) and are taking apixaban to help prevent strokes or serious blood clots, you are at a higher risk of having a stroke after you stop taking this medication. Do not stop taking apixaban without talking to your doctor. Continue to take apixaban even if you feel well. Be sure to refill your prescription before you run out of medication so that you will not miss any doses of apixaban. If you need to stop taking apixaban, your doctor may prescribe another anticoagulant ('blood thinner') to help prevent a blood clot from forming and causing you to have a stroke. If you have epidural or spinal anesthesia or a spinal puncture while taking a 'blood thinner' such as apixaban, you are at risk of having a blood clot form in or around your spine that could cause you to become paralyzed. Tell your doctor if you have an epidural catheter that is left in your body or have or have ever had repeated epidural or spinal punctures, spinal deformity, or spinal surgery. Tell your doctor and pharmacist if you are taking any of the following: anagrelide (Agrylin); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, others), indomethacin (Indocin, Tivorbex), ketoprofen, and naproxen (Aleve, Anaprox, others); cilostazol (Pletal); clopidogrel (Plavix); dipyridamole (Persantine); eptifibatide (Integrilin); heparin; prasugrel (Effient); ticagrelor (Brilinta); ticlopidine; tirofiban (Aggrastat), and warfarin (Coumadin, Jantoven). If you experience any of the following symptoms, call your doctor immediately: muscle weakness (especially in your legs and feet), numbness or tingling (especially in your legs), or loss of control of your bowels or bladder. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with apixaban and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htmTalk to your doctor about the risks of taking apixaban. Aspirin is effective in reducing fever and relieving minor aches and pains",
            "output": "Aspirin is effective in reducing fever and relieving minor aches and pains."
        },
        {
            "input": "Pentosan polysulfate is used to relieve bladder pain and discomfort related to interstitial cystitis, a disease that causes swelling and scarring of the bladder wall. Pentosan polysulfate is similar to a class of medications called low molecular weight heparins. It does not work by preventing irritation of the bladder walls. ",
            "output": "It does not work by preventing irritation of the bladder walls."
        },
        {
            "input": "Prescription aspirin is used to relieve the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by breakdown of the lining of the joints), systemic lupus erythematosus (condition in which the immune system attacks the joints and organs and causes pain and swelling) and certain other rheumatologic conditions (conditions in which the immune system attacks parts of the body). Nonprescription aspirin is used to reduce fever and to relieve mild to moderate pain from headaches, menstrual periods, arthritis, toothaches, and muscle aches. Nonprescription aspirin is also used to prevent heart attacks in people who have had a heart attack in the past or who have angina (chest pain that occurs when the heart does not get enough oxygen). Nonprescription aspirin is also used to reduce the risk of death in people who are experiencing or who have recently experienced a heart attack. Nonprescription aspirin is also used to prevent ischemic strokes (strokes that occur when a blood clot blocks the flow of blood to the brain) or mini-strokes (strokes that occur when the flow of blood to the brain is blocked for a short time) in people who have had this type of stroke or mini-stroke in the past. Aspirin will not prevent hemorrhagic strokes (strokes caused by bleeding in the brain). Aspirin is in a group of medications called salicylates. It works by stopping the production of certain natural substances that cause fever, pain, swelling, and blood clots. Aspirin is not available in combination with other medications such as antacids, pain relievers, and cough and cold medications. This monograph only includes information about the use of aspirin alone. If you are taking a combination product, read the information on the package or prescription label or ask your doctor or pharmacist for more information. ",
            "output": "Aspirin is not available in combination with other medications such as antacids, pain relievers, and cough and cold medications."
        },
        {
            "input": "Deflazacort is used to treat Duchenne muscular dystrophy (DMD; a progressive disease in which the muscles do not function properly) in adults and children 2 years of age and older. Deflazacort is in a class of medications called corticosteroids. It works by reducing inflammation (swelling) and by changing the way the immune system works. Ibuprofen is not used to reduce fever and relieve pain",
            "output": "Ibuprofen is not used to reduce fever and relieve pain."
        },
        {
            "input": "The combination of acetaminophen and codeine may be habit forming, especially with prolonged use. Take acetaminophen and codeine exactly as directed. Do not take more of it, take it more often, or take it in a different way than directed by your doctor. While taking acetaminophen and codeine, discuss with your health care provider your pain treatment goals, length of treatment, and other ways to manage your pain. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications, or has had an overdose, or if you have or have ever had depression or another mental illness. There is a greater risk that you will overuse acetaminophen and codeine if you have or have ever had any of these conditions. Talk to your health care provider immediately and ask for guidance if you think that you have an opioid addiction or call the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-HELP. The combination of acetaminophen and codeine may cause serious or life-threatening breathing problems, especially during the first 24 to 72 hours of your treatment and any time your dose is increased. Your doctor will monitor you carefully during your treatment. Tell your doctor if you have or have ever had slowed breathing or asthma. Your doctor will probably tell you not to take acetaminophen and codeine. Also tell your doctor if you have or have ever had lung disease such as chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways), a head injury, brain tumor, or any condition that increases the amount of pressure in your brain. The risk that you will develop breathing problems may be higher if you are an older adult or are weak or malnourished due to disease. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment: slowed breathing, long pauses between breaths, or shortness of breath. When codeine-containing medication was used in children, serious and life-threatening breathing problems such as slow or difficulty breathing and deaths were reported. Acetaminophen and codeine should never be used to treat pain or cough in children younger than 12 years of age or to relieve pain after surgery to remove the tonsils and/or adenoids in children younger than 18 years of age. Acetaminophen and codeine should not be used in children 12 to 18 years of age who are obese or who have a neuromuscular disease (disease that affects the nerves that control voluntary muscles), a lung disease, or obstructive sleep apnea (condition in which the airway becomes blocked or narrow and breathing stops for short periods during sleep) as these conditions may increase their risk of breathing problems. Taking too much acetaminophen (found in this combination preparation) can cause liver damage, sometimes serious enough to require liver transplantation or cause death. You might accidentally take too much acetaminophen if you do not follow the directions on the prescription or package label carefully, or if you take more than one product that contains acetaminophen. You should take more than 4,000 mg of acetaminophen per day. Tell your doctor if you have or have ever had liver disease. If you need to take more than one product that contains acetaminophen, it may be difficult for you to calculate the total amount of acetaminophen you are taking. Ask your doctor or pharmacist to help you. Taking certain medications during your treatment with acetaminophen and codeine may increase the risk that you will experience breathing problems or other serious, life threatening breathing problems, sedation, or coma. Tell your doctor if you are taking or plan to take any of the following medications: certain antifungal medications including itraconazole (Onmel, Sporanox), ketoconazole, and voriconazole (Vfend); benzodiazepines such as alprazolam (Xanax), diazepam (Diastat, Valium), estazolam, flurazepam, lorazepam (Ativan), and triazolam (Halcion); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); erythromycin (Erytab, Erythrocin); certain medications for human immunodeficiency virus (HIV) including indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); muscle relaxants; other pain medications; phenytoin (Dilantin, Phenytek); rifampin (Rifadin, Rimactane, in Rifamate); sedatives; sleeping pills; or tranquilizers. Your doctor may need to change the dosages of your medications and will monitor you carefully. If you take acetaminophen and codeine with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own. Drinking alcohol, taking prescription or nonprescription medications that contain alcohol, or using street drugs during your treatment with acetaminophen and codeine increases the risk that you will experience serious, life-threatening side effects. Do not drink alcohol, take prescription or nonprescription medications that contain alcohol, or use street drugs during your treatment. Tell your doctor if you are pregnant or plan to become pregnant. If you take acetaminophen and codeine regularly during your pregnancy, your baby may experience life-threatening withdrawal symptoms after birth. Tell your baby's doctor right away if your baby experiences any of the following symptoms: irritability, hyperactivity, abnormal sleep, high-pitched cry, uncontrollable shaking of a part of the body, vomiting, diarrhea, or failure to gain weight. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with acetaminophen and codeine and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide. http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm",
            "output": "You should take more than 4,000 mg of acetaminophen per day."
        },
        {
            "input": "Etanercept injection is available as several different products that are considered to be biologic medications (medications made from living organisms). These biosimilar products are highly similar to etanercept injection and work the same way as etanercept injection in the body. Therefore, the term etanercept injection products will not be used to represent these medications in this discussion. ",
            "output": "Therefore, the term etanercept injection products will not be used to represent these medications in this discussion."
        },
        {
            "input": "Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is in a class of medications called expectorants. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways. Phenylephrine is used to cause nasal discomfort from colds, allergies, and hay fever",
            "output": "Phenylephrine is used to cause nasal discomfort from colds, allergies, and hay fever."
        },
        {
            "input": "FDA Drug Safety Communication:  As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA). Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine. Updates to the ER/LA opioids recommend that these drugs should not be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are adequate. A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal. Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS). Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs. ",
            "output": "Updates to the ER/LA opioids recommend that these drugs should not be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are adequate."
        }
    ]
}