{ "Contributors": "BioLORD", "Source": "BioLORD", "URL": "https://huggingface.co/datasets/FremyCompany/BioLORD-Dataset", "Categories": [ "Explanation" ], "Definition": [ "Given a concise concept, generate a long detailed definition to explain it." ], "Reasoning": [], "Input_language": [ "English" ], "Output_language": [ "English" ], "Instruction_language": [ "English" ], "Domains": [ "Public Health" ], "Positive Examples": [], "Negative Examples": [], "Instances": [ { "input": "Concept: L-amino-acid dehydrogenase activity (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor)", "output": "oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor described as catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH." }, { "input": "Concept: anchor (Component of Study Protocol)", "output": "something described as designation for a planned activity, often marking the transition between epochs or elements of a clinical study plan (e.g., \"FPFV-first patient first visit\")." }, { "input": "Concept: Tub (Potency Unit)", "output": "Quantitative Concept described as a dosing unit equal to the amount of active ingredient(s) contained in a flat-bottomed container which is typically round and wider than deep." }, { "input": "Concept: SPRR1A Gene (Structural gene)", "output": "something described as this gene is involved in keratinization." }, { "input": "Concept: protozoal vaccine (Pharmacologic Substance)", "output": "Immunologic Factor described as suspensions of attenuated or killed protozoa administered for the prevention or treatment of infectious protozoan disease." }, { "input": "Concept: flutter auricular (Atrial fibrillation and flutter)", "output": "Atrial fibrillation and flutter described as rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave front traveling up the inter-atrial septum and down the right atrial free wall or vice versa. Unlike ATRIAL FIBRILLATION which is caused by abnormal impulse generation, typical atrial flutter is caused by abnormal impulse conduction. As in atrial fibrillation, patients with atrial flutter cannot effectively pump blood into the lower chambers of the heart (HEART VENTRICLES)." }, { "input": "Concept: CONSCIOUS (Psychoanalytic Personality Factors)", "output": "Mental Process described as state of being aware, or perceiving physical facts or mental concepts; a state of general wakefulness and responsiveness to environment; a functioning sensorium." }, { "input": "Concept: External Examination (Medical Examination)", "output": "Medical Examination described as an assessment of the outer body structures." }, { "input": "Concept: up regulation of gene silencing by miRNA, production of miRNAs (regulation of production of miRNAs involved in gene silencing by miRNA)", "output": "positive regulation of gene expression described as any process that activates or increases the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA." }, { "input": "Concept: pyridoxin (Vitamin B6 and vitamin B6 derivative)", "output": "something described as the 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990)." }, { "input": "Concept: Population genetics (heredity and evolution)", "output": "something described as the branch of genetics that focuses on gene distribution and transmission through populations." }, { "input": "Concept: mycothiol anabolism (Molecular Function)", "output": "something described as the chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." }, { "input": "Concept: alcohol; withdrawal, with delirium (Alcohol Related Disorders)", "output": "Disease or Syndrome described as an acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include CONFUSION; DELUSIONS; vivid HALLUCINATIONS; TREMOR; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may occasionally be fatal. It was formerly called delirium tremens." }, { "input": "Concept: SLC16A1 (Amino Acid, Peptide, or Protein)", "output": "something described as monocarboxylate transporter 1 (500 aa, ~54 kDa) is encoded by the human SLC16A1 gene. This protein is involved in monocarboxylate transport across the plasma membrane." }, { "input": "Concept: Moraxella catarrhalis, Beta-Lactamase Negative (Moraxella catarrhalis)", "output": "something described as any bacterial species identified as Moraxella catarrhalis that does not produce the enzyme beta-lactamase." }, { "input": "Concept: oculo-cerebro-cutaneous (OCC) syndrome (Disease or Syndrome)", "output": "Disease or Syndrome described as orbital cysts and other eye defects, multiple cerebral anomalies, and focal dermal defects are the principal characteristics of this syndrome." }, { "input": "Concept: QSTESTCD (Intellectual Product)", "output": "Intellectual Product described as a character or string that represents the short code name of the questionnaire test." }, { "input": "Concept: HTR2A: g102T>C (Gene or Genome)", "output": "HTR2A gene described as HTR2A-C Allele is a variant form of 20-kb 3-exon human HTR2A Gene (GPCR1/5HT2 Family), which encodes Serotonin 5-HT-2A Receptor, a conserved integral membrane 5-HT/serotonin receptor protein involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production by association with G proteins that activate a PI-calcium second messenger system. 5-HT is a biogenic hormone that affects specific receptors as a neurotransmitter, hormone, or mitogen. HTR2A contains several polymorphic sites. Different alleles differ in the concentration of RNA and protein product of 5HTR2A. HTR2A-C Allele contains a single-nucleotide polymorphism (102 T>C) in an intron and is expressed at a lower level than the 102 C>T allele." }, { "input": "Concept: Epilepsy, Complex Partial (Seizures, Focal)", "output": "Seizures, Focal described as a disorder characterized by recurrent partial seizures marked by impairment of cognition. During the seizure the individual may experience a wide variety of psychic phenomenon including formed hallucinations, illusions, deja vu, intense emotional feelings, confusion, and spatial disorientation. Focal motor activity, sensory alterations and AUTOMATISM may also occur. Complex partial seizures often originate from foci in one or both temporal lobes. The etiology may be idiopathic (cryptogenic partial complex epilepsy) or occur as a secondary manifestation of a focal cortical lesion (symptomatic partial complex epilepsy)." }, { "input": "Concept: CRADD Signaling Adaptor Protein (Biologically Active Substance)", "output": "CARD Signaling Adaptor Proteins described as a death domain receptor signaling adaptor protein that plays a role in signaling the activation of INITIATOR CASPASES such as CASPASE 2. It contains a death domain that is specific for RIP SERINE-THEONINE KINASES and a caspase-binding domain that binds to and activates CASPASES such as CASPASE 2." }, { "input": "Concept: Ethylene Trichloride (Halogenated hydrocarbons, general anesthetics)", "output": "Hydrocarbons, Halogenated described as a synthetic, light sensitive, volatile, colorless, liquid that is miscible with many non-polar organic solvents. Trichloroethylene is used mainly as a degreaser for metal parts. Upon combustion, it produces irritants and toxic gases. Occupational exposure to trichloroethylene is associated with excess incidences of liver cancer, kidney cancer and non-Hodgkin lymphoma. It is reasonably anticipated to be a human carcinogen." }, { "input": "Concept: Driver/Extractors (Reusable Devices)", "output": "Reusable Devices described as instruments designed to insert and extract implants and/or prostheses by applying force or torque during surgical or dental procedures. Driver/extractors are typically manual, handheld instruments with a working end that conforms to the device to be driven and a proximal end that can accept impact, pressure, or rotating forces according to the demands of the procedure. They are used mainly for the insertion and extraction of implants and prostheses (e.g., bone nails and pin, bone plates) during orthopedic procedures." }, { "input": "Concept: Optics (Occupation or Discipline)", "output": "Occupation or Discipline described as the branch of physics that describes the behavior and properties of light and the interaction of light with matter." }, { "input": "Concept: FAC075-Able to Shift Between Activities (Intellectual Product)", "output": "Intellectual Product described as functional Assessment of Cancer Therapy-Cognitive Function Version 3 - Perceived Cognitive Abilities: I am able to shift back and forth between two activities that require thinking." }, { "input": "Concept: Coronaviridae (Virus)", "output": "unclassified ssRNA positive-strand viruses described as a family of positive sense ssRNA viruses of zoonotic origin. They are the cause of respiratory, enteric, hepatic, and neurological diseases of varying severity in humans and animals. Bats, birds, and pigs act as major reservoirs of coronaviruses." }, { "input": "Concept: PODCI2-Have Pain Relief (PODCI Adolescent Parent-Reported Version Questionnaire Question)", "output": "something described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version (PODCI Adolescent Parent-Reported Version) As a result of my child's treatment, I expect my child: To have pain relief." }, { "input": "Concept: BPI Questionnaire Question (Clinical or Research Assessment Question)", "output": "Intellectual Product described as a question associated with the BPI questionnaire." }, { "input": "Concept: Ritonavir (Nitrogen and nitrogen compound)", "output": "Amides described as a drug used to treat infection with HIV (the virus that causes AIDS). It is also being studied in the treatment of some types of cancer. Ritonavir blocks the ability of HIV to make copies of itself and may block the growth of cancer cells. It is a type of anti-HIV agent and a type of protease inhibitor." }, { "input": "Concept: UDP-N-acetylglucosamine:beta-D-mannosyl-glycolipid beta-1,3-N-acetylglucosaminyltransferase activity (Molecular Function)", "output": "something described as catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids." }, { "input": "Concept: cynomolgus, Plasmodium (Plasmodium )", "output": "Eukaryote described as a protozoan parasite that occurs naturally in the macaque. It is similar to PLASMODIUM VIVAX and produces a type of malaria similar to vivax malaria (MALARIA, VIVAX). This species has been found to give rise to both natural and experimental human infections." }, { "input": "Concept: Ketone Bodies (SPECIFIC SUBSTANCE CHEMISTRY TESTS)", "output": "something described as the determination of the amount of ketone bodies (acetone, acetoacetic acid, beta-hydroxybutyric acid, beta-ketopentanoate and beta-hydroxypentanoate) present in a sample." }, { "input": "Concept: HEK (Gene or Genome)", "output": "Gene or Genome described as human EPHA3 wild-type allele is located in the vicinity of 3p11.2 and is approximately 375 kb in length. This allele, which encodes ephrin type-A receptor 3 protein, plays a role in mediating developmental events and may be involved in lymphoid function and differentiation." }, { "input": "Concept: Carney complex, types I and II (Disease or Syndrome)", "output": "Site-specific disorder of skin described as carney complex (CNC) has characteristics of spotty skin pigmentation, endocrine overactivity and myxomas. The prevalence is unknown but it is a rare disease. Skin pigmentation anomalies include lentigines and blue naevi. The most common endocrine gland manifestations are acromegaly, thyroid and testicular neoplasms and adrenocorticotropic hormone (ACTH)-independent Cushing's syndrome. Myxomas can be observed in the heart, skin and breast. Cardiac myxomas can develop in any cardiac chamber and may be multiple. One of the putative CNC genes located on 17q22-24, (PRKAR1A), has been found to encode the regulatory subunit (R1A) of protein kinase A. Heterozygous inactivating mutations of PRKAR1A were reported initially in 45 to 65% of CNC index cases, and may be present in about 80% of the CNC families presenting mainly with Cushing's syndrome. CNC is a dominantly inherited syndrome." }, { "input": "Concept: WEISS Criteria (WEISS System)", "output": "Clinical Attribute described as histopathologic criteria to evaluate adrenocortical tumors. These criteria include nuclear grade III or IV, mitotic rate greater than five per fifty high power fields, presence of atypical mitotic figures, presence of less than or equal to twenty five percent of clear or vacuolated cells that resemble normal zona fasciculata, diffuse architecture, necrosis, venous invasion, sinusoid invasion, and invasion of tumor capsule." }, { "input": "Concept: Refractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor (Refractory cancer)", "output": "something described as a malignant small round cell tumor with or without neural differentiation that is resistant to treatment." }, { "input": "Concept: perception of bacterium (Cell Function)", "output": "response to bacterium described as the series of events in which a stimulus from a bacterium is received and converted into a molecular signal." }, { "input": "Concept: Transesophageal Electrophysiologic Study (Diagnostic Procedure)", "output": "something described as measurements of the electrical activities of specific areas of the heart, taken from inside the ESOPHAGUS." }, { "input": "Concept: 5 HYDROXYTRYPTAMINE UPTAKE INHIB (Psychotropic Drugs)", "output": "Serotonin Antagonists described as any agent or substance which suppresses, prevents or opposes the actions of serotonin." }, { "input": "Concept: hemicholinium (Quaternary Ammonium Compounds)", "output": "Quaternary Ammonium Compounds described as a potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments." }, { "input": "Concept: Tie-Downs, Wheelchair (Technical Aids for the Disabled)", "output": "something described as devices (e.g., anchored straps) designed to secure an occupied wheelchair while it is in a motor vehicle. These devices are typically anchored to the vehicle floor." }, { "input": "Concept: Stage IA Gastric (Stomach) Cancer (Neoplastic Process)", "output": "Pathologic Stage I Gastric Cancer AJCC v8 described as stage IA includes: (T1, N0, M0). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis." }, { "input": "Concept: Capsules, Esophageal, pH Recording (Device Labeled for Single Use)", "output": "something described as capsules designed for clamping onto the esophageal wall tissue to obtain data of pH values in the esophagus. These capsules usually consist of a pH sensor (e.g., antimony electrode) and a telemetry (i.e., wireless) transmitter that send the pH data to a receiver worn by the patient. The data are recorded during a period of hours or a few days; the receiver includes dedicated software that permits recording and further viewing and analyzing the data at the end of the test. These capsules are used by ambulatory patients for esophageal pH measurement and recording; they facilitate correlating pH data to patient symptoms of gastro-esophageal reflux disease. These capsules are especially suited for patients who cannot tolerate nasal intubation; the capsules spontaneously detach and pass through the digestive system after the test is finished. Esophageal recording pH capsules may be supplied with accessories to facilitate calibration of the capsule (pH values)." }, { "input": "Concept: Stem Cells, Neural (Stem cells)", "output": "Multipotent Stem Cells described as a stem cell derived from embryonic sources or found in adult neural tissue. It has the capacity to generate all the multiple cell types found in the brain and spinal cord." }, { "input": "Concept: autologous CAR T product AUTO2 (Chimeric Antigen Receptor T-cells)", "output": "therapeutic autologous lymphocytes described as a preparation of autologous T lymphocytes that are genetically engineered to contain a dual-targeted chimeric antigen receptor (CAR), which includes the natural protein a proliferation-inducing ligand (APRIL; TNFSF13), that targets the tumor-associated antigens (TAAs) B-cell maturation antigen (BCMA; TNFRSF17) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI; TNFRSF13B), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous BCMA/TACI-targeted CAR T cells AUTO2 bind to BCMA and TACI expressed on tumor cells and induce selective cytotoxicity in those cells. In addition, AUTO2 carries the universal RQR8 safety \"off\" switch, which allows selective removal of the T cells through both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) following administration of rituximab if unacceptable side-effects occur. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C150509\" active clinical trials using this agent." }, { "input": "Concept: 16q22-q23.1 (Cell Component)", "output": "Chromosome band described as a chromosome band present on 16q" }, { "input": "Concept: CDHF14 (Cell Adhesion Molecule Gene)", "output": "Cell Adhesion Molecule Gene described as this gene plays a role in planar cell polarity." }, { "input": "Concept: L-Methionine (Amino acid - dietary)", "output": "Drugs used in the treatment of paracetamol poisoning described as a kind of amino acid" }, { "input": "Concept: lupinus (Fabaceae)", "output": "Plant described as a plant genus of the family FABACEAE that is a source of SPARTEINE, lupanine and other lupin alkaloids." }, { "input": "Concept: conical cornea (Non-Neoplastic Corneal Disorder)", "output": "Corneal Diseases described as a noninflammatory, usually bilateral protrusion of the cornea, the apex being displaced downward and nasally. It occurs most commonly in females at about puberty. The cause is unknown but hereditary factors may play a role. The -conus refers to the cone shape of the corneal protrusion." }, { "input": "Concept: ATP:D-glucuronate 1-phosphotransferase activity (Molecular Function)", "output": "something described as catalysis of the reaction: D-glucuronate + ATP = 1-phospho-alpha-D-glucuronate + ADP + 2 H(+)." }, { "input": "Concept: Gastrointestinal Stromal Tumor by AJCC v8 Stage (Soft Tissue Sarcoma by AJCC v8 Stage)", "output": "Neoplastic Process described as a term that refers to the staging of gastrointestinal stromal tumor (GIST), following the rules of the TNM AJCC v8 classification system. This staging system does not apply to pediatric GIST, familial GIST (germline mutant KIT or PDGFRA), or syndromic GIST (no AJCC staging system available)." }, { "input": "Concept: HER2/Neu Positive by Immunohistochemistry 21-30 Percent (HER2/Neu Positive by Immunohistochemistry)", "output": "something described as an immunohistochemical staining finding indicating that 21-30 percent of the cells in a tissue sample are expressing receptor tyrosine-protein kinase erbB-2." }, { "input": "Concept: Virologies, Plant (Occupation or Discipline)", "output": "Occupation or Discipline described as study of plant diseases of viral origin." }, { "input": "Concept: Thyrotropin Secretagogue (Amino Acid, Peptide, or Protein)", "output": "Hormone described as any structural or functional analogue that mimics the physiological actions of thyrotropin-releasing hormone (TRH). Although TRH analogues appear to have a minimal influence on the biosynthesis of TSH, they seem to exert various neuromodulating activities, such as central nervous system-stimulating, analeptic, analgesic, antidepressant, and neuroprotective effects." }, { "input": "Concept: Extremely dense breast composition (Finding)", "output": "something described as a mammographic finding of extremely dense breast composition, as defined by the visually estimated content of fibroglandular-density tissue within the breast, based on updated editions of the American College of Radiology's Breast Imaging Reporting and Data System (BI-RADS)." }, { "input": "Concept: X-Ray Film Changers, Cassette (Medical Device)", "output": "Medical Device described as a radiographic film/cassette changer is a device intended to be used during a radiologic procedure to move a radiographic film or cassette between X-ray exposures and to position it during the exposure." }, { "input": "Concept: Vocally disruptive behaviour (Finding)", "output": "something described as making vocal utterances that are distressing sounding and socially inappropriate due to their intensity, frequency, duration and/or setting, as a manifestation of some form of brain disease, usually dementia." }, { "input": "Concept: 15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity (Molecular Function)", "output": "something described as catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." }, { "input": "Concept: Mitoses Greater than or Equal to One per Square Millimeter (Finding)", "output": "Finding described as a result of a mitotic rate equal to or greater than one per square millimeter." }, { "input": "Concept: M\u00fcnchausen syndrome (Psychological Disorders)", "output": "Psychological Disorders described as a factitious disorder characterized by habitual presentation for hospital treatment of an apparent acute illness, the patient giving a plausible and dramatic history, all of which is false." }, { "input": "Concept: Metaplastic Carcinoma (Primary malignant neoplasm)", "output": "Malignant epithelial neoplasm - category described as a general term used to describe carcinomas arising from epithelial cells that have been transformed into another cells type (metaplastic epithelial cells). A representative example is the adenocarcinoma arising in Barrett esophagus. This term is also used to describe carcinomas in which the malignant epithelial cells show differentiation towards another cell type. A representative example of the latter is the metaplastic breast carcinoma in which the malignant glandular cells show squamous, spindle cell, or chondroid/osseous differentiation." }, { "input": "Concept: ADL02-Sum 16 to 19 (ADCS-ADL Severe Dementia Questionnaire Question)", "output": "ADCS-ADL Severe Dementia Questionnaire Question described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, Severe Dementia Version - Sum of Items 16-19." }, { "input": "Concept: MESOTHELIAL NEOPL (INTERNATIONAL CLASSIFICATION OF NEOPLASMS)", "output": "Malignant Neoplasms described as a benign or malignant neoplasm arising from mesothelial cells." }, { "input": "Concept: Escherichia coli O111 (Escherichia coli serogroup O)", "output": "Bacterium described as any bacterial organism that can be assigned to the species Escherichia coli and strain O111." }, { "input": "Concept: down regulation of IL-17A secretion (negative regulation of interleukin-17 production)", "output": "negative regulation of cytokine secretion described as any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17 secretion." }, { "input": "Concept: Karnofsky Performance Status 30 (Karnofsky Performance Status)", "output": "Karnofsky Performance Status described as severely disabled; hospitalization is indicated, although death not imminent." }, { "input": "Concept: indolalkylamine biosynthetic process (indolalkylamine metabolic process)", "output": "indole-containing compound biosynthetic process described as the chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." }, { "input": "Concept: TRAIL receptor activity (Molecular Function)", "output": "Molecular Function described as combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic cell death." }, { "input": "Concept: HAQ0212 (HAQ-DI Without VAS Questionnaire Question)", "output": "HAQ-DI Without VAS Questionnaire Question described as health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale (HAQ-DI Without VAS) Aids or devices that you usually use for any of these activities: Crutches." }, { "input": "Concept: Large epiphysis of proximal middle-finger phalanx (Anatomical Abnormality)", "output": "Enlarged epiphyses of the proximal phalanges of the hand described as abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the 3rd finger with respect to age-dependent norms." }, { "input": "Concept: Macedonian (Southern Slavic language)", "output": "Southern Slavic language described as a South Slavic language spoken principally in the Republic of Macedonia and by the Macedonian diaspora." }, { "input": "Concept: AIDS-Related Kaposi Sarcoma S1 (AIDS-Related Kaposi Sarcoma S (Systemic Illness) Status)", "output": "AIDS-Related Kaposi Sarcoma S (Systemic Illness) Status described as AIDS-related Kaposi sarcoma in which systemic illness is present; one or more of the following is true: history of opportunistic infections or thrush; one or more B symptoms is present; Karnofsky performance status score is under 70; other HIV-related illness is present, such as neurological disease or lymphoma." }, { "input": "Concept: Eruca alba (Plant)", "output": "Oriental herbs and natural substances letter S described as white mustard seed" }, { "input": "Concept: Cephalometric articulare to gonion line (Spatial Concept)", "output": "something described as a line extending from a constructed point representing the intersection of the inferior surface of the cranial base and the posterior outlines of the mandibular condyles to the most posterior inferior point on the outline of the angle of the mandible." }, { "input": "Concept: Chemical Safety (Safety)", "output": "Safety described as risk or hazard associated with the handling and use of chemicals." }, { "input": "Concept: Large Intestinal Wall Tissue (Tissue)", "output": "something described as the tissue of the large intestine. It is composed of four layers - mucosa, submucosa, smooth muscle with inner circular and outer longitudinal layers, and serosa. The mucosa has a large number of goblet cells but does not have any villi. The longitudinal muscle layer is incomplete. The longitudinal muscle is limited to three distinct bands, called teniae coli that run the entire length of the colon. Contraction of the teniae coli exerts pressure on the wall and creates a series of pouches, called haustra, along the colon. Epiploic appendages, pieces of fat-filled connective tissue, are attached to the outer surface of the colon." }, { "input": "Concept: Grade 3 Biliary Tract Infection, CTCAE (Biliary Tract Infection, CTCAE)", "output": "something described as IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated" }, { "input": "Concept: negative regulation of transdifferentiation (regulation of transdifferentiation)", "output": "Negative Regulation of Cell Differentiation described as any process that stops, prevents or reduces the frequency, rate or extent of transdifferentiation." }, { "input": "Concept: Fatigue Interference Score 2 (Clinical or Research Assessment Answer)", "output": "Clinical or Research Assessment Answer described as a subjective score of 2 on a fatigue scale that ranges from 0: Does Not Interfere to 10: Completely Interferes." }, { "input": "Concept: Alcohol Dehydrogenases, Sugar (Carbohydrate Dehydrogenases)", "output": "Amino Acid, Peptide, or Protein described as reversibly catalyzes the oxidation of a hydroxyl group of sugar alcohols to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2. and EC 1.1.99." }, { "input": "Concept: mntl hlth cnslng couple ea.1 (Therapeutic or Preventive Procedure)", "output": "something described as using couple counseling techniques with couples to resolve and/or alleviate their mental health disorder(s). Service is billed in 15-minute increments." }, { "input": "Concept: glucose phosphomutase (Isomerase)", "output": "Protein Family described as an enzyme that catalyzes the conversion of alpha D-glucose 1-phosphate to alpha D-glucose 6-phosphate. EC 5.4.2.2." }, { "input": "Concept: school refusal (Student Characteristics & Academic Environment)", "output": "something described as unwillingness of students to attend school or classes." }, { "input": "Concept: Interinstitutional Relation (Social Behavior)", "output": "Social Behavior described as the interactions between representatives of institutions, agencies, or organizations." }, { "input": "Concept: Postpartum Placental Separation (Finding During Childbirth Labor)", "output": "something described as a process in childbirth in which the placenta separates from its uterine lining, after the delivery of the baby." }, { "input": "Concept: Oxygen Species, Reactive (Element, Ion, or Isotope)", "output": "Oxygen Compounds, Inorganic described as molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of SIGNAL TRANSDUCTION and GENE EXPRESSION, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS." }, { "input": "Concept: up-regulation of long-day photoperiodism, flowering (positive regulation of post-embryonic development)", "output": "Physiologic Function described as any process that activates, maintains or increases long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." }, { "input": "Concept: Strength, Muscle (Physical Fitness)", "output": "Physical Fitness described as the amount of force generated by MUSCLE CONTRACTION. Muscle strength can be measured during isometric, isotonic, or isokinetic contraction, either manually or using a device such as a MUSCLE STRENGTH DYNAMOMETER." }, { "input": "Concept: FGFR-1 c.1966A>G (Cell or Molecular Dysfunction)", "output": "something described as a nucleotide substitution at position 1966 of the coding sequence of the FGFR1 gene where adenine has been mutated to guanine." }, { "input": "Concept: Talviraline (Non-nucleoside Reverse Transcriptase Inhibitor)", "output": "something described as a second generation, quinoxaline non-nucleoside reverse transcriptase inhibitor (NNRTI) with activity against human immunodeficiency virus 1 (HIV-1). Talviraline inhibits both HIV-1 induced cell killing and viral replication." }, { "input": "Concept: Grade 3 Vulval Infection, CTCAE (Vulval Infection, CTCAE)", "output": "something described as IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated" }, { "input": "Concept: drainage lymph nodes (Organ or Tissue Function)", "output": "Organ or Tissue Function described as the flow of fluids and lymphocytes in the lymphatic vessels, which are concentrated from tissue fluids, into a particular lymph node. Once the fluid has transited the lymph node, it is returned to the blood via the lymphatic system." }, { "input": "Concept: Subdural Spaces (Structure of meningeal spaces)", "output": "Subdural space described as beneath the dura mater." }, { "input": "Concept: 1p34.1 (Chromosome band)", "output": "Cell Component described as a chromosome band present on 1p" }, { "input": "Concept: Dental Laboratory Thermoplastic Forming Units, Injection (Medical Device)", "output": "Thermoplastic Forming Units described as thermoplastic forming units designed to manufacture dental plastic products with high dimensional precision using injection procedures. Typical injection molding machines consist of a heated barrel with a reciprocating screw driven by a motor. The motor feeds molten polymer (e.g., nylon, polypropylene) in a temperature-controlled split mold conformed in the shape of the final product. The product is ejected from the machine mold after the process is finished. Injection thermoplastic units are used in dental laboratories to produce a variety of plastic (e.g., resin) products, including denture bases." }, { "input": "Concept: Current Medical Status (Intellectual Product)", "output": "something described as a question about a person's description of the patient's current medical status." }, { "input": "Concept: scalp caput succedaneum (Disorder of fetal structure)", "output": "Birth injury to scalp described as a diffuse swelling of the scalp in a newborn, usually caused by the trauma of the scalp pushing through a narrowed cervix during birth. The swelling may extend across the midline of the scalp and may exhibit discoloration or bruising." }, { "input": "Concept: Grade 1 Intestinal Stoma Leak, CTCAE (Intestinal Stoma Leak, CTCAE)", "output": "Intestinal Stoma Leak, CTCAE described as asymptomatic diagnostic finding; intervention not indicated" }, { "input": "Concept: zygomycoses (Mycoses)", "output": "something described as any infection due to a fungus of the Zygomycota phylum. The disease typically involves the rhino-facial-cranial area, lungs, gastrointestinal tract, skin, or less commonly other organ systems. The infecting fungi have a predilection for invading vessels of the arterial system, causing embolization and subsequent necrosis of surrounding tissue." }, { "input": "Concept: estrous cycle phase (Organism Function)", "output": "biological phase described as the progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur." }, { "input": "Concept: Recurring Adverse Event (Finding)", "output": "something described as an adverse event that occurs and resolves during a cycle or course of medical intervention and then reoccurs in a later cycle or course." }, { "input": "Concept: positive regulation of cellular amine catabolic process (positive regulation of cellular amine metabolic process)", "output": "Organism Function described as any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." }, { "input": "Concept: Being tired made it hard for me to play or go out with my friends as much as I'd like (Clinical or Research Assessment Question)", "output": "Intellectual Product described as a question about whether an individual feels or felt that being tired made it hard for them to play or go out with friends as much as they would like." }, { "input": "Concept: ADL0117A (ADCS-ADL Questionnaire Question)", "output": "ADCS-ADL Questionnaire Question described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory (ADCS-ADL) If yes, which best describes his/her awareness of the meeting ahead of time." }, { "input": "Concept: ActRelationshipConcurrentWith (starts concurrent with)", "output": "General adjectival modifier described as occurring or operating at the same time." }, { "input": "Concept: polymorphism (Chromosomal abnormalities, gene alterations and gene variants)", "output": "Genetic finding described as simultaneous occurrence in the population of genomes showing allelic variations such as different phenotypes or restriction maps." }, { "input": "Concept: Male Penile Urethra and Female Urethra Carcinoma pTX TNM Finding v8 (Male Penile Urethra and Female Urethra Cancer Pathologic Primary Tumor TNM Finding v8)", "output": "Male Penile Urethra and Female Urethra Cancer Pathologic Primary Tumor TNM Finding v8 described as urethral cancer in which the primary tumor cannot be assessed." }, { "input": "Concept: Diffuse peripheral demyelination (Peripheral demyelination)", "output": "something described as a diffuse loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system." }, { "input": "Concept: Perca (Percinae)", "output": "something described as genus in the family Percidae." }, { "input": "Concept: Serine Peptidase Inhibitor Kazal Type 5 (Serine Peptidase Inhibitors, Kazal Type)", "output": "something described as a secreted serine peptidase inhibitor that consists of 15 KAZAL MOTIFS and inhibits KALLIKREINS KLK5, KLK7, and KLK14 as well as TRYPSIN. It plays important roles in protecting MUCOSA against infection and inflammation, and in maintaining the integrity of the skin. Mutations in the SPINK5 gene are associated with NETHERTON SYNDROME." }, { "input": "Concept: Pentoxifilina (Hemorrheologic agent, NOS)", "output": "P [Preparations] described as a methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased levels of cyclic adenosine monophosphate (cAMP) in erythrocytes, endothelium, and the surrounding tissues. This leads to vasodilation, improves erythrocyte flexibility, and enhances blood flow. In addition, the increased level of cAMP in platelets inhibits platelet aggregation, which may contribute to a reduction in blood viscosity. This agent also inhibits production of tumor necrosis factor-alpha and interferon-gamma, while it induces Th2-like (T-helper 2) cytokine production, thereby inhibiting Th1-mediated (T-helper 1) inflammatory and autoimmune responses." }, { "input": "Concept: Heart Myeloid Sarcoma (Neoplastic Process)", "output": "Sarcoma, Myeloid described as a rare extramedullary myeloid tumor that arises from the heart. It may present in association with or as a site of relapse of acute myeloid leukemia. Rare cases of myeloid sarcoma of the heart preceding acute myeloid leukemia have also been reported." }, { "input": "Concept: Reoviral Capsid Protein (Capsid Proteins)", "output": "Capsid Proteins described as a protein encoded by the reoviral genome that forms a three-layered icosahedral protein capsid for the virus." }, { "input": "Concept: Trauma, Physical Micro (Injury or Poisoning)", "output": "Wounds and Injuries described as small injuries caused by external force applied to the body including bones, muscles, nerves and tendons." }, { "input": "Concept: PDK4 gene (Serine/Threonine Protein Kinase Gene)", "output": "Gene or Genome described as this gene plays a role in the regulation of glucose and fatty acid metabolism." }, { "input": "Concept: Hyperconvex toenail (Overcurvature of nail)", "output": "something described as when viewed on end (with the tip of the toe pointing toward the examiner's eye) the curve of the toenail forms a tighter curve of convexity. []" }, { "input": "Concept: unsaturated fats (Organic Chemical)", "output": "Fatty acid glycerol esters described as fats containing one or more double bonds, as from oleic acid, an unsaturated fatty acid." }, { "input": "Concept: STIMULATOR, ULTRASOUND AND MUSCLE, FOR USE IN APPLYING THERAPEUTIC DEEP HEAT (Medical Device)", "output": "something described as (a) Ultrasound and muscle stimulator for use in applying therapeutic deep heat for selected medical conditions: An ultrasound and muscle stimulator for use in applying therapeutic deep heat for selected medical conditions is a device that applies to specific areas of the body ultrasonic energy at a frequency beyond 20 kilohertz and that is intended to generate deep heat within body tissues for the treatment of selected medical conditions such as relief of pain, muscle spasms, and joint contractures, but not for the treatment of malignancies. The device also passes electrical currents through the body area to stimulate or relax muscles. (b) Ultrasound and muscle stimulator for all other uses: An ultrasound and muscle stimulator for all other uses except for the treatment of malignancies is a device that applies to the body ultrasonic energy at a frequency beyond 20 kilohertz and applies to the body electrical currents and that is intended for the treatment of medical conditions by means other than the generation of deep heat within body tissues and the stimulation or relaxation of muscles as described in paragraph (a) of this section." }, { "input": "Concept: QS-FACT-Taxane Version 4 TESTCD (CDISC Questionnaire Terminology)", "output": "something described as functional Assessment of Cancer Therapy-Taxane Version 4 test code." }, { "input": "Concept: PRKAR1A-RARA Fusion Gene (Gene or Genome)", "output": "Fusion Gene described as a fusion gene that results from a cryptic rearrangement of chromosome 17 which fuses the first 100 nucleotides of exon 3 of the PRKAR1A gene to exon 3 of the RARA gene. This rearrangement is associated with acute promyelocytic leukemia." }, { "input": "Concept: HADS - I Feel as if I am Slowed Down (Intellectual Product)", "output": "something described as hospital Anxiety and Depression Scale - I feel as if I am slowed down." }, { "input": "Concept: Iodine (131I) Apamistamab (Radioimmunoconjugates)", "output": "Radioimmunoconjugates described as a radioimmunoconjugate consisting of BC8, a murine IgG1 anti-CD45 monoclonal antibody labeled with iodine 131 (I-131), with radioimmunotherapeutic properties. Using monoclonal antibody BC8 as a carrier for I-131 results in the targeted destruction of cells expressing CD45. CD45 is tyrosine phosphatase expressed on virtually all leukocytes, including myeloid and lymphoid precursors in bone marrow and mature lymphocytes in lymph nodes; it is also expressed on most myeloid and lymphoid leukemic cells, but not on mature erythrocytes or platelets." }, { "input": "Concept: germ-cell migration (Cell Function)", "output": "Migration, Cell described as the orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." }, { "input": "Concept: Renal tubulopathy with encephalopathy and liver failure syndrome (Disease or Syndrome)", "output": "Disease or Syndrome described as describes a spectrum of phenotypes with manifestations similar but milder than those seen in GRACILE syndrome and that can be associated with encephalopathy and psychiatric disorders. The prevalence is unknown, several cases have been described, presentation is variable. Most of the characteristics of GRACILE syndrome are present but they are often less severe. Signs of disturbances in iron metabolism have been described. Most infants die during the neonatal period. In those who survive, encephalopathy and psychiatric disorders have been described. This disease is due to different mutations in the BCS1L gene (2q35) encoding a protein essential in the assembly of complex III in the mitochondrial respiratory chain. Inherited autosomal recessively." }, { "input": "Concept: upregulation of antifungal innate immune response (regulation of antifungal innate immune response)", "output": "positive regulation of innate immune response described as any process that activates or increases the frequency, rate or extent of an antifungal innate immune response." }, { "input": "Concept: Estrogen Receptor Measurement (Laboratory Procedure)", "output": "Laboratory Procedure described as a measurement of estrogen receptor protein in a biological specimen." }, { "input": "Concept: Valproic Acid-Expanded Umbilical Cord Blood-derived CD34-positive Cells (Adoptive Cell Therapy Agent)", "output": "something described as a preparation of umbilical cord blood (UCB)-derived CD34-positive cells treated with valproic acid (VPA) with potential use in hematopoietic stem cell transplant (HSCT). Upon positive immunomagnetic selection of CD34-positive cells from UCB units, CD34-positive cells are expanded in culture with stem cell factor (SCF), FMS-like tyrosine kinase 3 ligand (Flt3L), thrombopoietin (TPO), and interleukin-3 (IL-3), treated with VPA, and infused into the patient. VPA, a histone deacetylase inhibitor (HDACi), may induce epigenetic changes in UCB hematopoietic stem cells (HSCs), resulting in expansion of CD34-positive cells enriched in short term (ST), intermediate term (IT), and long term (LT) marrow repopulating cells (RCs), which are capable of sustained hematopoietic engraftment following transplantation. Further, VPA-expanded UCB stem cells may shorten the time to neutrophil and platelet recovery and maintain long-term hematopoietic and immune reconstitution compared to untreated UCB grafts." }, { "input": "Concept: Hemidesmosome (Cell-Matrix Junction)", "output": "CELL SURFACE AND ASSOCIATED STRUCTURES described as a cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces." }, { "input": "Concept: COMF Regimen (Regimen Used to Treat Malignant Mesothelioma)", "output": "Regimen Used to Treat Malignant Mesothelioma described as a chemotherapy regimen consisting of cyclophosphamide, vincristine, methotrexate, and fluorouracil that may be used in the treatment of mesothelioma." }, { "input": "Concept: Norovirus Genogroup I RNA Measurement (Microbiology procedure)", "output": "something described as a measurement of Norovirus genogroup I RNA present in a sample." }, { "input": "Concept: Fistula, Rectal (Congenital anomaly of rectum)", "output": "Fistula of genitourinary tract described as the presence of a fistula affecting the rectum." }, { "input": "Concept: pyrrolizidine alkaloid metabolism (alkaloid metabolic process)", "output": "Molecular Function described as the chemical reactions and pathways involving pyrrolizidine alkaloid." }, { "input": "Concept: Chesapeake Bay Retriever (Sporting Breed)", "output": "Sporting Breed described as a powerful, muscular retriever with a slightly wavy, rather short coat. Both the outer coat and dense wooly undercoat are oily for water-repellence. The coat may be a shade of brown, red, or tan, ranging from a dead-grass-straw color to a deep dark brown with red overtones. The average height range is 21-26 inches and the average weight range is 55-80 pounds." }, { "input": "Concept: Cup Feeding Establishment: Infant (Digestion & Nutrition)", "output": "Digestion & Nutrition described as establishment of cup feeding for hydration and nourishment of an infant" }, { "input": "Concept: Abdominal regions (Body Location or Region)", "output": "Abdomen described as any portion of the body that lies within the boundary, either internally or externally, of the abdomen: superior margin, the thorax; inferior margin, the pelvis; lateral margins, the ribs." }, { "input": "Concept: Ocular Adnexal Lymphoma pM1a TNM Finding v7 (Finding)", "output": "Finding described as noncontiguous involvement of tissues or organs external to the ocular adnexa (e.g., parotid gland, submandibular gland, lung, liver, spleen, kidney, breast, etc.)." }, { "input": "Concept: Investigational Product Return Record (Records)", "output": "Records described as documentation tracking investigational product (IP) inventory returns to/from a distribution center, depot, and/or trial site. May include, but is not limited to, courier documentation and packing or inventory listing." }, { "input": "Concept: Dog Breed (Classification)", "output": "Classification described as a type of dog known for its special or distinctive characteristics." }, { "input": "Concept: Cuff Inflators (Medical Device)", "output": "Medical Device described as devices used to add air to a cylindrical chamber. Cuff inflators typically consist of a rubber bulb, tubing, and a locking screw mechanism that retains air in the chamber." }, { "input": "Concept: gallic acid biosynthetic process (Molecular Function)", "output": "gallate metabolic process described as the chemical reactions and pathways resulting in the formation of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid)." }, { "input": "Concept: Highly Elevated (Qualitative Concept)", "output": "Qualitative Concept described as an indication that something is highly raised or increased above normal levels or limits." }, { "input": "Concept: RING DERMOID OF CORNEA (Dermoid cyst of cornea)", "output": "Autosomal dominant hereditary disorder described as ring dermoid of cornea has characteristics of annular limbal dermoids (growths with a skin-like structure) with corneal and conjunctival extension. Less than 30 cases have been described. Transmission is autosomal dominant and mutations in the PITX2 gene on chromosome 4q25 have been suggested as a potential cause of the condition." }, { "input": "Concept: Cyclazocine (Opioid Receptor Agonist)", "output": "Analgesics described as analgesic with mixed narcotic agonist-antagonist properties." }, { "input": "Concept: Brain ventricle (Body Space or Junction)", "output": "Cerebral cortex described as a composite, fluid-filled substructure of the brain that includes the left lateral ventricle and the right lateral ventricle of the endbrain. Each lateral ventricle connects via an interventricular foramen to the third ventricle. The third ventricle, which separates the left and right parts of the interbrain, connects via the cerebral aqueduct to the fourth ventricle. The fourth ventricle, in turn, connects to the central canal of the spinal cord. They are intercommunicating cavities that contain cerebrospinal fluid ( Carpenter-1983 )." }, { "input": "Concept: Germanium, NOS (carbon group elements)", "output": "something described as rare metal element with a blue-gray appearance, atomic symbol Ge, atomic number 32, and atomic weight 72.59." }, { "input": "Concept: Concepts, Physical (Latvian translation of the Medical Subject Headings)", "output": "Swedish translation of the Medical Subject Headings described as the entities of matter and energy, and the processes, principles, properties, and relationships describing their nature and interactions." }, { "input": "Concept: Swine-origin influenza A (H1N1) virus (Influenza A virus subtype N1)", "output": "Virus described as a subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918." }, { "input": "Concept: NK T cell proliferation (Cell Function)", "output": "Cell Function described as the expansion of a NK T cell population by cell division." }, { "input": "Concept: RBM5 wt Allele (Gene or Genome)", "output": "something described as human RBM5 wild-type allele is located in the vicinity of 3p21.3 and is approximately 30 kb in length. This allele, which encodes RNA-binding protein 5, is involved in RNA homopolymer binding and recognition. The gene may have a role as a tumor suppressor in lung cancer." }, { "input": "Concept: Spot-on applicator (Applicator - device)", "output": "Applicator - device described as device for administration by spot-on use." }, { "input": "Concept: RaceAsian (Race - finding)", "output": "Racial group described as a person having origins in any of the original peoples of the Far East, Southeast Asia, Indian subcontinent; e.g., Cambodia, China, India, Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, or Vietam." }, { "input": "Concept: NEPHROBLASTOMA OVEREXPRESSED GENE (Ligand Binding Protein Gene)", "output": "Ligand Binding Protein Gene described as this gene plays a role in growth factor modulation and cellular proliferation." }, { "input": "Concept: Cyclohexanecarboxylic acid, 3-((3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)-1,4,5-trihydroxy-, (1S-(1alpha,3beta,4alpha,5alpha))- (C [Preparations])", "output": "Cinnamates described as a naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. (From J Chromatogr A 1996;741(2):223-31; Biosci Biotechnol Biochem 1996;60(5):765-68)." }, { "input": "Concept: 101 Mouse (Mammal)", "output": "Mice, Inbred Strains described as inbr: 66. Genet: A^w. Origin: Dunn, 1936." }, { "input": "Concept: Grade 1 Keratitis, CTCAE (Finding)", "output": "something described as asymptomatic; clinical or diagnostic observations only; intervention not indicated" }, { "input": "Concept: TP53 wt Allele (TP53 gene)", "output": "TP53 gene described as human TP53 wild-type allele is located in the vicinity of 17p13.1 and is approximately 19 kb in length. This allele, which encodes cellular tumor antigen p53 protein, plays a role in cell cycle regulation during the G0/G1transition. Alterations of the TP53 gene occur as both somatic and germline mutations in human malignancies in select cancer-prone families with Li-Fraumeni syndrome." }, { "input": "Concept: negative regulation of tooth development (negative regulation of animal organ morphogenesis)", "output": "something described as any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth." }, { "input": "Concept: positive regulation of calcium ion transport into cytosol involved in cellular response to ionic osmotic stress (positive regulation of calcium ion transport into cytosol)", "output": "positive regulation of calcium ion transport into cytosol described as any positive regulation of calcium ion transport into cytosol that is involved in cellular response to salt stress." }, { "input": "Concept: PODCI211 (Intellectual Product)", "output": "Intellectual Product described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version (PODCI Adolescent Parent-Reported Version) During the last week, how happy has your child been with: His/her body?" }, { "input": "Concept: Socialize (Physical activity)", "output": "something described as interactions with one or more individuals, usually with a common purpose or with regards to a common topic of interest." }, { "input": "Concept: cyclin dependent kinase inhibitor 2D (Cyclin-Dependent Kinase Inhibitor Gene)", "output": "something described as this gene is involved in the regulation of both cyclin-dependent kinase activity and cell cycle progression." }, { "input": "Concept: Testicular Hemorrhage (Genitourinary Hemorrhage, CTCAE)", "output": "Finding described as a disorder characterized by bleeding from the testis." }, { "input": "Concept: positive regulation of resting T cell proliferation (positive regulation of T cell proliferation)", "output": "Cell Function described as any process that activates or increases the rate or extent of resting T cell proliferation." }, { "input": "Concept: biological control (Biological Processes)", "output": "Biological Processes described as any process that modulates a measurable attribute of any biological process, quality or function." }, { "input": "Concept: Biopsy prostate (Reproductive organ and breast histopathology procedures)", "output": "Biopsy of bladder described as removal of tissue from the prostate for microscopic examination. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C51701\" active clinical trials using this agent." }, { "input": "Concept: gluc.assay tst ea.tst (Laboratory Procedure)", "output": "something described as analyzing a client/patient's blood sample to assess the blood plasma concentration in his or her glucose. Service is billed per test." }, { "input": "Concept: Lisdexamfetamine Dimesylate (Amphetamine and amphetamine derivative)", "output": "Appetite Depressants described as the dimesylate form and prodrug of the d-isomer of amphetamine, a non-catecholamine sympathomimetic amine with central nervous system (CNS) stimulating activity. Upon administration, lisdexamphetamine is converted to dextroamphetamine through cleavage of the lysine group. Dextroamphetamine acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from its storage sites in nerve terminals in the CNS, and inhibits their uptake within the mesocorticolimbic system, a major component of the brain reward system, resulting in measurable behavioral changes such as euphoria, mental alertness and excitement and appetite suppression. As a CNS stimulant, this agent may increase blood pressure." }, { "input": "Concept: Therapeutic Breast Surgery (Local Therapy)", "output": "something described as a surgical procedure to remove treat disorders of the breast." }, { "input": "Concept: Infiltrating Bladder Urothelial Carcinoma, Micropapillary Variant (Infiltrating Bladder Urothelial Carcinoma)", "output": "Neoplastic Process described as an infiltrating bladder transitional cell carcinoma exhibiting micropapillary growth pattern." }, { "input": "Concept: Tag (Potency Unit)", "output": "something described as a unit of presentation used to represent the quantity of product that is found in a single discrete entity where the pharmaceutical dose form is a type of tag. Comment: For example, to describe the strength of an ear tag: \"contains 1000 mg per tag\"." }, { "input": "Concept: Acute Myeloid Leukemia with t(11;15)(p15;q35); NUP98-JARID1A (Childhood Acute Myeloid Leukemia with NUP98 Rearrangement)", "output": "Childhood Acute Myeloid Leukemia with NUP98 Rearrangement described as acute myeloid leukemia (AML) with a cytogenetically, cryptic fusion of NUP98 to JARID1A, t(11;15)(p15;q35). It typically has an megakaryocytic phenotype and occurs in 10% of pediatric, non-Down Syndrome-related acute megakaryoblastic leukemia (AMKL) cases." }, { "input": "Concept: Ishak Score 4 (Intellectual Product)", "output": "Intellectual Product described as marked bridging fibrosis (portal to portal and porto-central) is present." }, { "input": "Concept: \"Respiratory, Developmental, Rehabilitative and Restorative Service Providers\"; Physical Therapist, Ergonomics (Professional or Occupational Group)", "output": "Professional or Occupational Group described as a licensed physical therapist who has demonstrated specialized knowledge and skills pertaining to the workplace, occupational demands, prevention of work-related injury, management of the worker with job-related symptoms or participation restrictions, and provides individual, group or population level evaluation, intervention and consulting to enhance worker performance." }, { "input": "Concept: Childhood Lymphomatoid Granulomatosis (Lymphomatoid Granulomatosis)", "output": "something described as an Epstein-Barr virus-associated B-cell lymphoproliferative disorder in children that nearly always affects the lungs, with skin involvement in 50% of the cases. Morphologically, three grades are recognized: grade I, II, and III." }, { "input": "Concept: Raf/MEK dual kinase inhibitor RO5126766 (Pharmacologic Substance)", "output": "Pharmacologic Substance described as a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity. Raf/MEK dual kinase Inhibitor RO5126766 specifically inhibits the kinase activities of Raf and MEK, resulting in the inhibition of of target gene transcription that promotes malignant transformation of cells. Both Raf and MEK are serine/threonine-specific kinases that respond to extracellular stimuli, such as mitogens, and are involved in the regulation of cellular processes, such as gene expression, mitosis, differentiation, and apoptosis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C80060\" active clinical trials using this agent." }, { "input": "Concept: vomeronasal system (Body System)", "output": "Body System described as accessory nasal chemoreceptive system present in terrestrial vertebrates; involved in chemical intra-species communication." }, { "input": "Concept: pain; eye (Globe finding)", "output": "COMMON EYE AND EYELID SYMPTOMS described as painful sensation in the eye." }, { "input": "Concept: Anti-FLT3 Monoclonal Antibody IMC-EB10 (Antineoplastic Antibody)", "output": "Flt-3-targeting Agent described as a fully human, IgG1 monoclonal antibody directed against the FLT3 tyrosine kinase receptor (CD135) with potential antineoplastic activity. Upon binding to FLT3, anti-FLT3 monoclonal antibody IMC-EB10 blocks FLT3 ligand binding to FLT3 and subsequent FLT3 phosphorylation, which may result in the inhibition of FLT3-mediated signal transduction pathways. In addition, this agent may stimulate an anti-FLT3 antibody-dependent cell-mediated cytotoxicity (ADCC) against FLT3-expressing tumor cells, which may result in the inhibition of cellular proliferation and survival in FLT3-expressing cells. FLT3 (FLK2), a class III tyrosine kinase receptor, is overexpressed or mutated in most B lineage and acute myeloid leukemias." }, { "input": "Concept: SNF/Subacute Care - Respiratory Therapist, Certified (Professional or Occupational Group)", "output": "Professional or Occupational Group described as care of residents in a long-term care environment. Respiratory modalities delivered include those similar in the general care and critical care areas but provided to less critical patients." }, { "input": "Concept: Convulsive Therapies (Medical & Physical Treatment)", "output": "Procedure on brain described as convulsions induced in order to treat MENTAL DISORDERS. It is used primarily in the treatment of severe affective disorders and SCHIZOPHRENIA." }, { "input": "Concept: Stage IV Carcinoma of Esophagus AJCC v6 (Esophageal Cancer by AJCC v6 Stage)", "output": "something described as stage IV esophageal cancer is divided into stage IVA and stage IVB, depending on where the cancer has spread. In stage IVA, cancer has spread to nearby or distant lymph nodes. In stage IVB, cancer has spread to distant lymph nodes and/or organs in other parts of the body." }, { "input": "Concept: facial; paralysis (CRANIA NERVE ABNORMALITIES)", "output": "Paralysed described as severe or complete loss of facial muscle motor function. This condition may result from central or peripheral lesions. Damage to CNS motor pathways from the cerebral cortex to the facial nuclei in the pons leads to facial weakness that generally spares the forehead muscles. FACIAL NERVE DISEASES generally results in generalized hemifacial weakness. NEUROMUSCULAR JUNCTION DISEASES and MUSCULAR DISEASES may also cause facial paralysis or paresis." }, { "input": "Concept: health services research tag (tag term)", "output": "health science research described as research that examines the organization and management of health care services and their impact on the access to, delivery, outcomes, and quality of such services; see RTs and indexing manual tag term list for specific concepts included; index at the 'T' emphasis level." }, { "input": "Concept: cardiolipin biosynthetic process (phosphatidylglycerol biosynthetic process)", "output": "cardiolipin metabolic process described as the chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." }, { "input": "Concept: Gallium Ga 68 Citrate (Radioisotopes)", "output": "something described as a radiopharmaceutical citrate salt form of the positron-emitting radioisotope gallium Ga 68, with potential imaging activity upon positron emission tomography (PET). Upon administration of Gallium Ga 68 citrate, the gallium Ga 3+ ion dissociates from the weak citrate chelator. As Ga3+ is very similar to iron (Fe3+) in chemical properties, this ion acts as an iron analogue. Ga3+ binds to the iron-binding protein transferrin, distributes in blood, and enters and accumulates in the extracellular fluid space of inflamed or tumor-bearing tissue. In turn, the Ga3+-transferrin complex binds to transferrin receptors and is taken up by tumor cells. Tumor cells can then be imaged upon PET. Compared to healthy cells, tumor cells have increased iron metabolism and transferrin receptor expression. Increased Ga3+ uptake is seen in inflamed and infected tissues as well. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C121554\" active clinical trials using this agent." }, { "input": "Concept: Lumican Proteoglycan (Small Leucine-Rich Proteoglycans)", "output": "Small Leucine-Rich Proteoglycans described as a small leucine-rich proteoglycan that contains 10 tandem leucine repeats and four N-linked sites within the leucine repeat region that may be substituted with KERATAN SULFATE. These properties and its horseshoe shape allow it to mediate interactions among COLLAGEN molecules within fibrils. It is expressed in most mesenchymal tissues as well as the CORNEA, where it functions to maintain transparency." }, { "input": "Concept: SKIN ATROPHY (Degenerative disorder)", "output": "Degenerative skin disorder described as partial or complete wasting (atrophy) of the skin." }, { "input": "Concept: regulation of gliogenesis (regulation of neurogenesis)", "output": "something described as any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia." }, { "input": "Concept: Multiple renal cysts (Disease or Syndrome)", "output": "Disease or Syndrome described as the presence of many cysts in the kidney." }, { "input": "Concept: Consensus Cardiac Classification System Test Name (CDISC SDTM Terminology)", "output": "something described as classification system test name for cardiac parameters that are authored or endorsed by organizations." }, { "input": "Concept: Autosomal recessive cerebellar ataxia, epilepsy, intellectual disability syndrome due to RUN and cysteine rich domain containing beclin 1 interacting protein deficiency (Autosomal recessive hereditary disorder)", "output": "something described as an extremely rare autosomal recessive hereditary cerebellar ataxia disorder with characteristics of early onset of progressive, mild to moderate gait and limb ataxia, moderate to severe dysarthria and nystagmus or saccadic pursuit, frequently associated with epilepsy, moderate intellectual disability, delayed speech acquisition and hyporeflexia in the upper extremities. Hyperreflexia in the lower extremities may also be associated." }, { "input": "Concept: negative regulation of actin filament annealing (regulation of actin filament annealing)", "output": "regulation of actin filament annealing described as any process that stops, prevents or reduces the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments." }, { "input": "Concept: Family veillonellaceae (Bacterium)", "output": "Bacterium described as a family of gram-negative bacteria, in the phylum FIRMICUTES." }, { "input": "Concept: LACTOCOCCUS LACTIS SUBSP. LACTIS (Lactococcus)", "output": "Lactococcus lactis described as a species of Gram positive, cocci shaped, lactic acid bacteria assigned to the phylum Firmicutes. It is used in the manufacturing of cultured milk products and differs from Lactococcus lactis subsp. cremoris by being more hardy to salt, pH, and high temperatures." }, { "input": "Concept: 1,2-Benzphenanthrene (Polycyclic Hydrocarbons)", "output": "Carcinogens described as 1,2-Benzphenanthrenes. POLYCYCLIC COMPOUNDS obtained from coal tar." }, { "input": "Concept: EC 3.1.1.53 (Hydrolase)", "output": "Hydrolase described as sialate O-acetylesterase (523 aa, ~58 kDa) is encoded by the human SIAE gene. This protein plays a role in the removal of O-acetyl ester groups from sialic acid." }, { "input": "Concept: CDISC Questionnaire ADCS-CGIC Test Code Terminology (Intellectual Product)", "output": "something described as test codes of questionnaire questions associated with the Alzheimer's disease cooperative study-clinical global impression of change questionnaire for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM)." }, { "input": "Concept: Non-lymphocytic leukaemia (Korean Standard Classification of Disease Version 5)", "output": "Leukemia described as a progressive, proliferative disease of blood cells, originating from immature granulocytes." }, { "input": "Concept: Nucleic Acid Folding (Molecular Function)", "output": "Molecular Function described as process by which a nucleic acid macromolecule assumes an energetically favorable three-dimensional conformation as a result of intrinsic and extrinsic atomic physical forces." }, { "input": "Concept: Charitable Behavior (Interpersonal Relations)", "output": "Prosocial Behavior described as generous or spontaneous goodness as manifested in actions for the benefit of others, especially for the needy, poor, or helpless." }, { "input": "Concept: Valsalva Maneuver (Techniques M-Z)", "output": "cardiology services, treatments, and remedies described as forced expiratory effort against a closed GLOTTIS." }, { "input": "Concept: YWHAE-FAM22 ESS (Uterine Corpus Endometrial Stromal Sarcoma)", "output": "Neoplastic Process described as a rare, high grade sarcoma that arises from the endometrial stroma. It is characterized by round cell morphology. It was previously also known as undifferentiated uterine sarcoma. In 2014, high grade endometrial stromal sarcoma was reclassified and is currently considered a distinct and rare neoplasm. It appears to have a prognosis that falls between low grade endometrial stromal sarcoma and undifferentiated sarcoma." }, { "input": "Concept: Transfer RNA, Phe (Biologically Active Substance)", "output": "RNA, Transfer, Amino Acid-Specific described as a transfer RNA which is specific for carrying phenylalanine to sites on the ribosomes in preparation for protein synthesis." }, { "input": "Concept: Malignant Hemangiopericytoma Nonmetastatic (Neoplastic Process)", "output": "something described as a rare malignant mesenchymal neoplasm that is believed to have its origin in smooth muscle derived pericytes without evidence of metastases." }, { "input": "Concept: Secretory component deficiency (Immunoglobulin A deficiency)", "output": "Disease or Syndrome described as deficiency of secretory IgA (polymers of 2-4 IgA monomers are linked by two additional chains) and is the primary antibody response at the mucosal level, where it forms immune complexes with pathogens and allergens." }, { "input": "Concept: WHODAS 2.0 12+24-item Version Interviewer-administered - Finding Solutions to Problems (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)", "output": "something described as world Health Organization Disability Assessment Schedule 2.0 12+24-item Version Interviewer-administered (WHODAS 2.0 12+24-item Version Interviewer-administered) In the past 30 days, how much difficulty did you have in: Analysing and finding solutions to problems in day-to-day life?" }, { "input": "Concept: CDISC CDASH Units for Exposure Terminology (CDISC CDASH Terminology)", "output": "something described as a terminology subset of the CDISC SDTM Unit codelist created for CDASH Units for Exposure codelist." }, { "input": "Concept: CSS09-First Attempt Damage (Intellectual Product)", "output": "something described as columbia-Suicidality Severity Rating Scale Screening (C-SSRS Screening) Initial/first attempt actual lethality/medical damage." }, { "input": "Concept: Microelectric current each 15 minutes (Therapeutic or Preventive Procedure)", "output": "Electrical or magnetic described as applying a microelectric current to a client's body part or region to create penetrating heat. Service is billed in 15-minute increments." }, { "input": "Concept: chf (Subarachnoid fissure)", "output": "Cerebral Fissure described as a cleft-like opening in the wall of the lateral ventricle that appears when the choroid plexus is dissected away. It extends from the interventricular foramen to the end of the temporal horn of the lateral ventricle. The part nearest the interventricular foramen is between the lateral edge of the fornix and the upper surface of the thalamus; in the inferior horn it is between the fimbria and the stria terminalis ( Gray-1918a )." }, { "input": "Concept: Bypasses, Heart-Lung (Thoracic Surgical Procedures)", "output": "something described as diversion of the blood flow to the heart directly to the aorta, via a pump oxygenator, avoiding the heart and/or the lungs; a form of extracorporeal circulation used in heart surgery; see BLOOD OXYGENATOR for the portion that oxygenates the blood and EXTRACORPOREAL CIRCULATION for the portion that recirculates one's blood." }, { "input": "Concept: Respiratory Therapist, Registered - Patient Education (Professional or Occupational Group)", "output": "something described as the focus of patient and family education activities is to promote knowledge of disease process, medical therapy, and self help. Respiratory therapists are uniquely qualified to provide this service in regard to cardiopulmonary diseases and injury." }, { "input": "Concept: E2F6 Gene (Transcription factor genes)", "output": "Gene or Genome described as this gene is involved in cell cycle entry." }, { "input": "Concept: medicine tropical (Biomedical Occupation or Discipline)", "output": "something described as branch of medicine concerned with diseases, mainly of parasitic origin, common in tropical and subtropical regions." }, { "input": "Concept: Refractory Chronic Myelomonocytic Leukemia (Neoplastic Process)", "output": "Leukemia, Myelomonocytic, Chronic described as chronic myelomonocytic leukemia that is resistant to treatment." }, { "input": "Concept: Unit device (Medical Device)", "output": "Medical Device described as a largely self-contained device designed to be incorporated into a larger device." }, { "input": "Concept: Endogenous Factors (Functional Concept)", "output": "Functional Concept described as the consideration of naturally occurring body factors as a variable in disease incident, transmission, and control." }, { "input": "Concept: C-SSRS Children's Since Last Visit - Active Suicidal Ideation with Specific Plan and Intent (Intellectual Product)", "output": "C-SSRS Children's Since Last Visit Questionnaire Question described as columbia-Suicidality Severity Rating Scale Children's Since Last Visit (C-SSRS Children's Since Last Visit) Have you decided how or when you would make yourself not alive anymore/kill yourself? Have you planned out (worked out the details of) how you would do it? What was your plan? When you made this plan (or worked out these details), was any part of you thinking about actually doing it?" }, { "input": "Concept: spores (Cells)", "output": "Organism Forms described as the reproductive elements of lower organisms, such as BACTERIA; FUNGI; and cryptogamic plants." }, { "input": "Concept: outcome (Other Finding)", "output": "Functional Concept described as 1. events or experiences that clinicians or investigators examining the impact of an intervention or exposure measure because they believe such events or experiences may be influenced by the intervention or exposure. 2. (SDTM) The result of carrying out a mathematical or statistical procedure. NOTE: 1. such events and experiences are called clinical outcomes independently of whether they are part of the original question/protocol of the investigation. [1. Guyatt, G., Schunemann H., Dept. epidemiology & statistics, McMaster University-personal communication] See also variable; outcome can be a result of analysis; outcome is more general than endpoint in that it does not necessarily relate to a planned objective of the study.outcome. The measureable characteristic (clinical outcome assessment, biomarker) that is influenced or affected by an individual's baseline state or an intervention as in a clinical trial or other exposure." }, { "input": "Concept: LmddA-LLO-chHER2 Fusion Protein-secreting Live-attenuated Listeria Cancer Vaccine ADXS31-164 (Pharmacologic Substance)", "output": "Cancer Vaccines described as a cancer vaccine containing a live, highly attenuated strain of the Gram-positive bacterium Listeria monocytogenes (LmddA) encoding a fusion protein composed of a chimeric peptide comprised of three highly immunogenic epitopes of the human tumor-associated antigen (TAA) HER2/neu (chHER2) fused to a non-hemolytic fragment of the immunostimulant listeriolysin O (LLO) protein, with potential immunostimulatory and antineoplastic activities. Upon administration of the LmddA-LLO-chHER2 vaccine ADXS31-142, the LmddA is taken up by phagocytic cells; then the listeriolysin portion of the expressed LLO-chHER2 can form pores in the phagolysosomes and the fusion protein can escape into the cytosol. In turn, the LLO-chHER2 is processed and presented to the immune system by the major histocompatibility complex (MHC) I on the phagocytic cells. Antigen presentation activates the immune system to exert an immune response involving the recruitment and activation of T lymphocytes against HER2-expressing tumor cells, and inhibits tumor-infiltrating T regulatory cells (Tregs) and myeloid-derived suppressor cells (MDSCs). This eventually results in tumor cell lysis. HER2/neu, a tyrosine kinase receptor belonging to the epidermal growth factor receptor (EGFR) family, is overexpressed in various tumor cell types. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C121541\" active clinical trials using this agent." }, { "input": "Concept: Drop Metastatic Neoplasm to the Spinal Cord (Neoplastic Process)", "output": "Neoplastic Process described as an intradural extramedullary spinal metastasis from an intracranial tumor through the cerebrospinal fluid." }, { "input": "Concept: Extnl DT Spec (Intellectual Product)", "output": "something described as documentation of data import, export and transfer specifications; includes but is not limited to data regarding diary, lab, IVRS, imaging; may also include but is not limited to transfer from one group to another, and data transfer from IVRS to EDC." }, { "input": "Concept: endoplasmic reticulum body organization (organelle organization)", "output": "organelle organization described as a process that is carried out at the cellular level which results in the formation of ER (endoplasmic reticulum) body. ER body is a compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." }, { "input": "Concept: Go Shopping Less Often than Like Due to Hearing Problem (Intellectual Product)", "output": "something described as a question about whether having a hearing problem causes an individual to go shopping less often than they would like." }, { "input": "Concept: Surgical Hand Drills, Middle Ear (Medical Device)", "output": "something described as hand drills designed used during otologic surgical procedures involving the middle ear structures. These devices consist of a manually propelled or powered (e.g., electric, pneumatic) instrument that typically includes a chuck and other detachable components such as drill bits and burs; some middle ear drills are used with special guides. Battery operated electric drills provide autonomous operation without connection to external power sources. Middle-ear surgical hand drills frequently include special guides for particular procedures such as stapedectomy and the placing of choclear implants." }, { "input": "Concept: viral DNA repair (Genetic Function)", "output": "something described as the process of restoring viral DNA after damage or errors in replication." }, { "input": "Concept: Comprehensive Peripheral Neuropathy Gene Deletion/Duplication Panel Reagents (IVD Panels, Human Genetics, Peripheral Neuropathy, Comprehensive)", "output": "Medical Device described as molecular assay reagents intended to identify deletions and duplications in the majority of genes known to be associated with peripheral neuropathy, a collection of disorders affecting the peripheral nervous system. Hereditary peripheral neuropathies may affect motor, sensory, and/or autonomic nerve function. Genetic variants at multiple loci have been associated with peripheral neuropathy. These reagents are intended to detect deletions and duplications in the majority of peripheral neuropathy-associated loci simultaneously." }, { "input": "Concept: Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) Gene (Gene or Genome)", "output": "Adaptor Signaling Protein Gene described as this gene is involved in signal transduction. It plays a role in the activation and development of T cells." }, { "input": "Concept: Myeloblastic Leukemia, Acute (Myeloproliferative disease)", "output": "something described as clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES." }, { "input": "Concept: A. spinalis posterior (Cranial branch of vertebral artery)", "output": "Posterior spinal artery and its branches described as an artery arising from the vertebral artery at the level of the medulla oblongata that descends along the posterior roots of the spinal nerves on each side of the spinal cord with branches supplying the spinal cord, pia mater and medulla." }, { "input": "Concept: growth hormone receptor binding (Molecular Function)", "output": "hormone receptor binding described as interacting selectively and non-covalently with the growth hormone receptor." }, { "input": "Concept: Contact dermatitis caused by solar radiation (Contact dermatitis due to solar radiation)", "output": "Noninfectious, vesicular AND/OR bullous disease described as inflammation of the skin resulting from exposure to the sun." }, { "input": "Concept: Neonatal multifocal myoclonic seizure (Disease or Syndrome)", "output": "something described as neonatal multifocal myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) wich occurs at multiple sites." }, { "input": "Concept: squamous cell carcinoma, paranasal sinus and nasal cavity (Squamous cell carcinoma of the head and neck)", "output": "Nasal Cavity and Paranasal Sinus Carcinoma described as a rare, keratinizing or non-keratinizing squamous cell carcinoma arising from the mucosal epithelium of the nasal cavity or the paranasal sinuses. It affects most often the maxillary sinus. Less frequently, it arises from the nasal cavity, ethmoid sinus, sphenoid sinus, and frontal sinus. Symptoms include nasal fullness, epistaxis, rhinorhea, pain, and paresthesia. Patients with nasal squamous cell carcinoma usually present earlier than patients with maxillary sinus carcinoma and have a better prognosis compared to the latter group." }, { "input": "Concept: HAEMORRHAGE GASTRIC (Gastrointestinal Hemorrhage)", "output": "Intraabdominal hemorrhage described as bleeding from the gastric wall." }, { "input": "Concept: muscle cell cellular homeostasis (anatomical structure homeostasis)", "output": "cellular homeostasis described as the cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." }, { "input": "Concept: Pharmaceutical Technology (Biomedical Occupation or Discipline)", "output": "Health Occupations described as the application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients." }, { "input": "Concept: Apical part of cell (cellular anatomical entity)", "output": "cellular anatomical entity described as the region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." }, { "input": "Concept: Scanning Systems, Ultrasonic/Near-Infrared Spectroscopy Laser, Intravascular (Medical Device)", "output": "something described as scanning systems that combine ultrasonic and near-infrared (NIR) laser scanning spectroscopy that are designed to provide data and images showing both the characteristics of the structure (e.g., degree of stenosis) of the blood vessels and the lipid composition of the inner layers of the vascular walls (i.e., intravascular). These systems consist of a central unit typically mounted on a cart that includes a high frequency generator, a laser source, data processors, appropriate software, and a display; the system also includes a detachable catheter with a hub at the proximal end with connectors for the ultrasound and optical output of the central unit. Intravascular ultrasonic/NIR laser scanning systems are intended to facilitate diagnosis and most appropriate treatment of vascular diseases." }, { "input": "Concept: CNS-excluded Nervous System Neoplasm and Disorder (Intellectual Product)", "output": "NCI CTEP Simplified Disease Classification Terminology described as CNS-excluded Nervous System Neoplasm and Disorder is an NCI Cancer Therapeutic Evaluation Program (CTEP) Simplified Disease Classification (SDC) category used to organize cancer-related disease coding that harmonizes with and supports reporting based on the global standard Medical Dictionary for Drug Regulatory Reporting (MedDRA) terminology." }, { "input": "Concept: TLR Agonist CADI-05 (Organic Chemical)", "output": "Organic Chemical described as a poly-Toll-like receptor (TLR) agonist polyantigenic vaccine containing heat killed Mycobacterium indicus pranii (Mycobacterium w or Mw) with potential immunostimulating and antineoplastic activities. Upon administration, poly-TLR agonist polyantigenic vaccine activates a number of TLRs, which may result in macrophage and plasmacytoid dendritic cell (pDC) stimulation; secretion of interferon alpha; production of pro-inflammatory cytokines; upregulation of co-stimulatory molecules, enhanced T and B-cell stimulatory responses; T cell proliferation, and a Th1 immune response. TLRs are transmembrane receptors that recognize structurally conserved microbial molecules such as bacterial cell-surface lipopolysaccharides (LPS), lipoproteins, lipopeptides, lipoarabinomannan and flagellin, among others; immune responses stimulated by TLR activation may result in antineoplastic effects." }, { "input": "Concept: LEFT VENTRICULAR MID INFERIOR SEGMENT (Body Part, Organ, or Organ Component)", "output": "Body Part, Organ, or Organ Component described as the inferior portion of the mid-cavity division of the left ventricular myocardium as determined using the AHA 17-Segment Model (Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS; American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002 Jan 29;105(4):539-42.)." }, { "input": "Concept: negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape (Cell Function)", "output": "Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." }, { "input": "Concept: OMS (Pharmacologic Substance)", "output": "Organic Chemical described as brand name of morphine sulfate" }, { "input": "Concept: Testers, Solid Material Hardness (Measuring Instruments)", "output": "Measuring Instruments described as testers which measure the ability of solid materials to resist plastic deformation or fracture when a force or load is applied to them. Common types of hardness tests include scratch, indentation, and rebound hardness. Scratch hardness is the measure of the resistance of a material to scratching of its surface. Scratch hardness testers usually consist of some type of an indenter with a very hard tip (e.g., tungsten carbide, diamond), a load or applied force, and a scale to measure the pressure applied by the load or force on the indenter to scratch the surface of a material. Scratch hardness is commonly measured on the Mohs scale. Indentation hardness is a measure of the resistance of a material to permanent plastic deformation due to a constant compression load from a sharp object. Indentation hardness testers typically feature an indenter made of a very hard material (e.g., diamond, steel, tungsten carbide) to which a load or force is applied, a platform to hold in place the material to be tested, a load to apply the force to the indenter, and various measuring mechanisms to measure the indentation made in the test material by the indenter according to different hardness scales (e.g., Brinell, Knoop, Rockwell, Shore, Vickers, etc.). Rebound hardness, also known as dynamic hardness, measures the height of the bounce of a hard-tipped hammer dropped from a fixed height onto a material. Rebound hardness testers usually have a diamond tipped hammer and a measuring scale to measure the height of the bounce caused by the return energy of the tester according to the hardness of the test material. Some hardness testers are interfaced with computers that aid in selecting the test parameters for the hardness test and in presenting results. Some hardness testers can be pocket-sized or be designed to fit in hard to reach locations; many use electronic components to calculate hardness. Hardness testers that make microscopic indentations on delicate or brittle materials and use a microscope to make precision measurements of the indentations (microhardness testers) are also available. Hardness testers are used in laboratories and sometimes in the field to ascertain the hardness of materials used in many different applications; they may have clinical applications in testing the hardness of dental materials and other materials used in clinical engineering." }, { "input": "Concept: Loss of fat tissue (Decreased adipose tissue)", "output": "Finding described as a loss of adipose tissue." }, { "input": "Concept: Hepatitis B Virus Core Antibody (Hepatitis B Virus Antibody Measurement)", "output": "Laboratory Procedure described as a measurement of the hepatitis B virus core antibody in a biological specimen." }, { "input": "Concept: Heart Valve Cage Device (Medical Device)", "output": "something described as the part of a mechanical heart valve designed to contain and guide the occluder ball in a cage and ball valve." }, { "input": "Concept: Anterior chamber cells grade 2+ (Finding)", "output": "Anterior chamber cells described as anterior chamber cells with 16-25 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp." }, { "input": "Concept: polyomavirus bk (Bovine papillomavirus group, NOS)", "output": "Virus described as a species of POLYOMAVIRUS apparently infecting over 90% of children but not clearly associated with any clinical illness in childhood. The virus remains latent in the body throughout life and can be reactivated under certain circumstances." }, { "input": "Concept: ascospore wall beta-glucan metabolism (meiotic cell cycle process)", "output": "Molecular Function described as the chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." }, { "input": "Concept: Test Site Location (Location)", "output": "something described as the geographic location in which a test is managed." }, { "input": "Concept: High severity (Finding)", "output": "Finding described as RAPID3 weighted score = 4.3-10.0" }, { "input": "Concept: Yohimbine (Secologanin Tryptamine Alkaloids)", "output": "medications for the reproductive system described as a plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION." }, { "input": "Concept: QS-RAND Social Support Survey TESTCD (CDISC Questionnaire Terminology)", "output": "something described as test codes of questionnaire questions associated with the RAND Social Support Survey Instrument (RAND Social Support Survey) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." }, { "input": "Concept: clinical trial information (Intellectual Product)", "output": "Information described as data collected in the course of a clinical trial or documentation related to the integrity or administration of that data. A superset of clinical trial data." }, { "input": "Concept: Human leukocyte antigen DR typing (HLA antigen typing)", "output": "HLA Typing described as the identification of the type of human leukocyte antigen, class II, antigen-D-related (HLA-DR), in a biological specimen." }, { "input": "Concept: SUB1 wt Allele (SUB1 gene)", "output": "something described as human SUB1 wild-type allele is located in the vicinity of 5p13.3 and is approximately 18 kb in length. This allele, which encodes activated RNA polymerase II transcriptional coactivator p15 protein, plays a role in chromatin organization." }, { "input": "Concept: TPN Acquired Cholestasis (Cholestasis)", "output": "something described as cholestasis that results from prolonged total parenteral nutrition. It is caused by diminished bile flow from the liver into the duodenum. It may result in cirrhosis and liver failure. Preterm infants are most susceptible to liver damage." }, { "input": "Concept: sophorose transport (Cell Function)", "output": "Cell Function described as the directed movement of a sophoroseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." }, { "input": "Concept: Epidermal Growth Factor Receptor Met766 Ala767insAlaSerVal (Cell or Molecular Dysfunction)", "output": "something described as an insertion of the amino acid sequence alanine-serine-valine between the methionine at position 766 and the alanine at position 767 of the epidermal growth factor receptor protein." }, { "input": "Concept: stenosis; pulmonary, artery (Disorder of pulmonary circulation)", "output": "Thoracic Diseases described as an abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." }, { "input": "Concept: MGC126344 (Gene or Genome)", "output": "something described as human DLL4 wild-type allele is located in the vicinity of 15q14 and is approximately 10 kb in length. This allele, which encodes Delta-like protein 4, plays a role in the modulation of notch signaling and may play a role in neovascularization." }, { "input": "Concept: PODCI1-Friends Limited by: Fear (Intellectual Product)", "output": "Intellectual Product described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported Version (PODCI Pediatric Parent-Reported Version) If you answered \"sometimes\" or \"never or rarely\" to Question 60 above, was your child's activity limited by: Fear the other kids won't like him/her?" }, { "input": "Concept: ch81c6 (Pharmacologic Substance)", "output": "Amino Acid, Peptide, or Protein described as a chimeric, murine-human monoclonal antibody directed against the tumor-associated antigen (TAA) tenascin (hexabrachion) that may, when conjugated with a radioisotope, be useful in radiotherapy or radioimaging. Tenascin, an extracellular matrix glycoprotein is upregulated in certain pathological conditions such as infection, inflammation and tumor growth, and is highly expressed in the tumor microenvironment in some malignancies." }, { "input": "Concept: Protein Misfolding Disorder (Disease or Syndrome)", "output": "Disease or Syndrome described as disorders caused by dysfunctions in PROTEIN FOLDING and degradation or clearance of misfolded proteins." }, { "input": "Concept: TRAF2 (Ubiquitin-Transferase Gene)", "output": "Gene or Genome described as this gene is involved in signal transduction and inhibition of apoptosis." }, { "input": "Concept: 5a-reductase inhibition (Therapeutic or Preventive Procedure)", "output": "endocrine-modulating drug therapy described as treatment with a 5a-reductase inhibitor with the goal of suppressing the conversion of testosterone to dihydrotestosterone." }, { "input": "Concept: Microwave Therapy Systems, Tissue Ablation, Sweat Glands (Medical Device)", "output": "Microwave Therapy Systems, Tissue Ablation described as tissue-ablation microwave therapy systems designed for external ablation of regions in the underarms where the sweat glands are located to lessen local sweat. These systems typically consist of a central unit with a microwave generator, a handpiece to deliver the microwave energy that includes antennas and a detachable usually disposable tip to apply the energy, a control to regulate the quantity of energy applied, and additional cooling means for thermal protection of the skin. The system may also include a software to guide the performance of the procedure and the application of vacuum for tissue stabilization. Sweat gland ablation (i.e., thermolysis) are used to treat patients with axillary hyperhidrosis." }, { "input": "Concept: \"Technologists, Technicians & Other Technical Service Providers\"; \"Technician, Pathology\" (Professional or Occupational Group)", "output": "Professional or Occupational Group described as an individual with knowledge of specific techniques and instruments who performs all of the routine tests in a medical laboratory and who has the ability to discriminate between similar factors that directly affect procedures and results." }, { "input": "Concept: BAY1436032 (Pharmacologic Substance)", "output": "something described as an orally available pan-inhibitor of mutant forms of the metabolic enzyme isocitrate dehydrogenase type 1 (IDH1; IDH-1; IDH1 [NADP+] soluble), including forms with mutations of arginine 132 (IDH1(R132)), with potential antineoplastic activity. Upon administration, pan-mutant-IDH-1 inhibitor BAY-1436032 specifically inhibits the activity of IDH1 mutant forms, which prevents the formation of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG). This prevents 2HG-mediated signaling and leads to both an induction of cellular differentiation and an inhibition of cellular proliferation in tumor cells expressing IDH1 mutant forms. IDH1 mutations, including IDH1(R132) mutations, are highly expressed in certain malignancies; they initiate and drive cancer growth by both blocking cell differentiation and catalyzing the formation of 2HG. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C131690\" active clinical trials using this agent." }, { "input": "Concept: Variant Angina Pectoris (Disease or Syndrome)", "output": "Cardiomyopathies described as a clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity." }, { "input": "Concept: 16\u03b1-hydroxyprednisole-16,17-acetonide (Corticosteroids, moderately potent)", "output": "Synthetic glucocorticoid described as a nonfluorinated corticosteroid anti-inflammatory agent used topically for DERMATOSES." }, { "input": "Concept: positive regulation of endothelial cell chemotaxis to fibroblast growth factor (Cell Function)", "output": "regulation of endothelial cell chemotaxis to fibroblast growth factor described as any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." }, { "input": "Concept: Having dreams and goals that are different from most people your own age (Clinical or Research Assessment Question)", "output": "Intellectual Product described as a question about how often a person thought about having dreams and goals that are different from most people their age." }, { "input": "Concept: Modified VDBP-Macrophage Activator EF-022 (Pharmacologic Substance)", "output": "Pharmacologic Substance described as a modified version of vitamin D binding protein (VDBP; Gc protein) macrophage activator, with potential antineoplastic and anti-angiogenic activities. Upon administration, modified VDBP-macrophage activator EF-022, acting in a similar manner as VDBP-macrophage activating factor (GcMAF), is able to activate tumoricidal macrophages, thereby enhancing the killing and eradication of cancer cells. In addition, EF-022 may inhibit tumor cell proliferation, migration and angiogenesis. VDBP is a glycoprotein and precursor for macrophage activating factor (MAF), which promotes macrophage activation; however VDBP can be deglycosylated by serum alpha-N-acetylgalactosaminidase, which is secreted from cancerous cells, and cannot be converted to MAF. Thus, the macrophage activation cascade is often impaired in tumor cells and plays a key role in tumor immunosuppression. Modification of VDBP stabilizes MAF." }, { "input": "Concept: gastric inhibitory polypeptide receptor binding (Molecular Function)", "output": "Molecular Function described as interacting selectively and non-covalently with a gastric inhibitory polypeptide receptor." }, { "input": "Concept: Unit Conversion Factor (Quantitative Concept)", "output": "Mathematical Operator described as an operator used to convert units from one scale to another." }, { "input": "Concept: Ras-related protein Ral-A (G Protein Gene)", "output": "G Protein Gene described as this gene plays a role in signal transduction and mediates receptor signaling." }, { "input": "Concept: 1-N-ethyl sisomicin (N [Preparations])", "output": "Antibiotic described as the sulfate salt form of netilimicin, a semisynthetic, water soluble aminoglycoside antibiotic. Netilmicin is derived from sisomicin, a naturally occurring aminoglycoside antibiotic produced by the fermentation of Micromonospora inyoensis. Netilmicin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, netilmicin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death." }, { "input": "Concept: Memory and Learning Tests (Neuropsychological Tests)", "output": "Neuropsychological Tests described as tests designed to evaluate general and specific areas of behaviors and abilities associated with memory and/or learning." }, { "input": "Concept: Single-Photon Emission Computed Tomography Systems (Scanning Systems, Gamma Camera)", "output": "Scanning Systems, Gamma Camera described as gamma camera systems that produce cross-sectional slices of the in vivo distribution of an administered radiopharmaceutical in the body, acquired at various angles around the patient and displayed as a computer-reconstructed tomographic image. These systems typically include a mechanical gantry to support and rotate the camera head and collimators in a circular or elliptical orbit around the body. Systems with multiple camera heads and/or coincidence imaging capabilities are also available. Single photon emission tomography systems are mostly used for whole-body bone imaging, brain perfusion studies, and cardiac imaging." }, { "input": "Concept: OLIVER SYNDROME (Dysostoses)", "output": "something described as a very rare syndrome with characteristics of intellectual deficit, postaxial polydactyly and epilepsy. To date, seven individuals in three families have been reported. Facial features are not characteristic except for a prominent jaw. Concordant features in all subjects are postaxial polydactyly, which in four individuals affect also the feet, and intellectual deficit, which is usually severe, with absent or indistinct speech. Seizures are common with onset in the first months of life or in early childhood. Cutaneous syndactyly, camptodactyly and clinodactyly of fingers and brachydactyly and syndactyly of the toes have been recorded." }, { "input": "Concept: Hyperinsulinism in the Infant of a Diabetic Mother (Disease or Syndrome)", "output": "Disease or Syndrome described as transient hypoglycemia that occurs in the infant of a diabetic mother due to increased postnatal insulin release as a result of in utero exposure to maternal hyperglycemia." }, { "input": "Concept: sense of pain (SENSATION, PAIN, AND COMFORT COMPONENT)", "output": "Symptomatology described as causing physical or psychological misery, pain or distress." }, { "input": "Concept: Superior Palpebral Fold (Body Part, Organ, or Organ Component)", "output": "Head and Neck Part described as a crease in the skin of the upper eyelid." }, { "input": "Concept: 1-18:2-2-18:3-digalactosyldiacylglycerol desaturase activity (oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water)", "output": "something described as catalysis of the reaction: 1-18:2-2-18:3-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." }, { "input": "Concept: Cervical Carcinoma FIGO Stage IB2 (Cervical Cancer pT1b TNM Finding v8)", "output": "something described as cervical cancer with clinically visible lesion more than 4.0 cm in greatest dimension." }, { "input": "Concept: Ctrx (Neurotoxins)", "output": "Crotalid Venoms described as a specific complex of toxic proteins from the venom of Crotalus durissus terrificus (South American rattlesnake). It can be separated into a phospholipase A and crotapotin fragment; the latter consists of three different amino acid chains, potentiates the enzyme, and is specifically neurotoxic." }, { "input": "Concept: bone pin (Prostheses and Implants)", "output": "Fixation device described as single/multiple component metallic bone fixation appliances and accessories are devices intended to be implanted consisting of one or more metallic components and their metallic fasteners. The devices contain a plate, a nail/plate combination, or a blade/plate combination that are made of alloys, such as cobalt-chromium-molybdenum, stainless steel, and titanium, that are intended to be held in position with fasteners, such as screws and nails, or bolts, nuts, and washers. These devices are used for fixation of fractures of the proximal or distal end of long bones, such as intracapsular, intertrochanteric, intercervical, supracondylar, or condylar fractures of the femur; for fusion of a joint; or for surgical procedures that involve cutting a bone. The devices may be implanted or attached through the skin so that a pulling force (traction) may be applied to the skeletal system." }, { "input": "Concept: Allopathic & Osteopathic Physicians; Radiology, Hospice and Palliative Medicine (Professional or Occupational Group)", "output": "something described as a radiologist with special knowledge and skills to prevent and relieve the suffering experienced by patients with life-limiting illnesses. This specialist works with an interdisciplinary hospice or palliative care team to maximize quality of life while addressing physical, psychological, social and spiritual needs of both patient and family throughout the course of the disease, through the dying process, and beyond for the family. This specialist has expertise in the assessment of patients with advanced disease; the relief of distressing symptoms; the coordination of interdisciplinary patient and family-centered care in diverse venues; the use of specialized care systems including hospice; the management of the imminently dying patient; and legal and ethical decision making in end-of-life care." }, { "input": "Concept: pMRsr (oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor)", "output": "something described as catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." }, { "input": "Concept: Hypercupraemia (Blood copper abnormal)", "output": "Blood drug level high described as an abnormally elevated concentration of copper in the blood circulation. This term refers to the total copper concentration. []" }, { "input": "Concept: Very preterm infant (Infant, Newborn)", "output": "Infant, Newborn described as a baby born alive with a gestational age between 28 to less than 32 weeks." }, { "input": "Concept: Tumor Findings Collection Date Time (Collection Date Time)", "output": "Collection Date Time described as the date and time of tumor findings data collection." }, { "input": "Concept: Anatomical coordinate (Anatomical location)", "output": "Anatomical location described as anatomical location which specifies the relationship between one or more physical anatomical entities in terms of ..." }, { "input": "Concept: TDY (SRY gene)", "output": "Gene or Genome described as human SRY wild-type allele is located in the vicinity of Yp11.3 and is approximately 1 kb in length. This allele, which encodes sex determining region Y protein, plays a fundamental role in testis formation in humans, and may also play a role in regulation of transcription. Mutations in this gene may result in gonadal dysgenesis." }, { "input": "Concept: Dwarfism, Campomelic (Deformity of limb)", "output": "Multiple malformation syndrome with osteochondro- dysplasia described as a congenital disorder of CHONDROGENESIS and OSTEOGENESIS characterized by hypoplasia of endochondral bones. In most cases there is a curvature of the long bones especially the TIBIA with dimpling of the skin over the bowed areas, malformation of the pelvis and spine, 11 pairs of ribs, hypoplastic scapulae, club feet, micrognathia, CLEFT PALATE, tracheobronchomalacia, and in some patients male-to-female sex reversal (SEX REVERSAL, GONADAL). Most patients die in the neonatal period of respiratory distress. Campomelic dysplasia is associated with haploinsufficiency of the SOX9 TRANSCRIPTION FACTOR gene." }, { "input": "Concept: Trabulsiella McWhorter et al. 1992 (Bacterium)", "output": "Enterobacteriaceae described as any bacteria that is not assigned to the species level but can be assigned to the Trabulsiella genus level." }, { "input": "Concept: Autoimmune Atrophic Chronic Gastritis (Disease or Syndrome)", "output": "Gastritis, Atrophic described as chronic atrophic gastritis that is caused by autoimmune destruction of parietal cells in the stomach resulting in hypochlorhydria and decreased production of intrinsic factor." }, { "input": "Concept: protein expression profile (Biological Markers)", "output": "Biological Markers described as information about all proteins that are made in blood, other body fluids, or tissues, at certain times. A protein expression profile may be used to find and diagnose a disease or condition and to see how well the body responds to treatment." }, { "input": "Concept: response to organic substance (Cell Function)", "output": "response to chemical described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." }, { "input": "Concept: steatosis (Abnormal degeneration)", "output": "Physical shape described as acumulation of adipose tissue in intracytoplasmic or extracellular spaces." }, { "input": "Concept: epithelial to mesenchymal transition involved in cardiac fibroblast development (cardiac epithelial to mesenchymal transition)", "output": "cardiac epithelial to mesenchymal transition described as a transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will mature into a cardiac fibroblast." }, { "input": "Concept: Fibroma, no International Classification of Diseases for Oncology subtype (Neoplasms, Connective Tissue)", "output": "Epithelioma described as a benign tumor of fibrous or fully developed connective tissue." }, { "input": "Concept: negative regulation of cytotoxic T-lymphocyte degranulation (negative regulation of leukocyte degranulation)", "output": "negative regulation of leukocyte degranulation described as any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation." }, { "input": "Concept: Facility, Cardiac Care (Health Care Related Organization)", "output": "Manufactured Object described as institutions specializing in the care of patients with heart disorders." }, { "input": "Concept: CRYSTALLOGR (Research Techniques)", "output": "something described as the branch of science that deals with the geometric description of crystals and their internal arrangement." }, { "input": "Concept: facet joints (Joints)", "output": "Joints described as the joint that occurs between facets of the interior and superior articular processes of adjacent VERTEBRAE." }, { "input": "Concept: Complete duplication of the middle bone of the little toe (Anatomical Abnormality)", "output": "something described as complete duplication of the middle phalanx of the 5th toe." }, { "input": "Concept: Inferior cervical ganglion (Sympathetic Ganglia)", "output": "something described as a sympathetic ganglion located at the seventh cervical vertebral level." }, { "input": "Concept: Grade 4 Anal fistula (Anal Fistula, CTCAE 5)", "output": "something described as life-threatening consequences; urgent intervention indicated" }, { "input": "Concept: Xq24 (Chromosome band)", "output": "Chromosome band described as a chromosome band present on Xq" }, { "input": "Concept: SCURVY (Disease or Syndrome)", "output": "Vascular Hemostatic Disorders described as abnormally low concentrations of vitamin C in the blood." }, { "input": "Concept: 1q21-q23 (Chromosome band)", "output": "Chromosome band described as a chromosome band present on 1q" }, { "input": "Concept: pleural sacs (Structure of pulmopleural compartment)", "output": "Body Part, Organ, or Organ Component described as serous sac that surrounds the lung and lines the cavity of a hemithorax. Examples: There are only two canonical instances, right and left pleural sacs." }, { "input": "Concept: YANG DEFIC (Pathologic Function)", "output": "Pathologic Function described as in the YIN-YANG system of philosophy and medicine, a lack of vital energy (called yangxu in Chinese). It manifests itself in various systemic and organic diseases." }, { "input": "Concept: Millimole per Milliliter (moles per unit volume)", "output": "Potency Unit described as a unit of concentration (molarity unit) equal to one mole of solute in one liter of solution." }, { "input": "Concept: Brugmansia Pers. (Plant)", "output": "Plant described as a genus of solanaceae that refers to small to mid-size trees with large, strong-smelling, trumpet-shaped flowers hanging downward. Most parts of the plant contain ATROPINE, SCOPOLAMINE HYDROBROMIDE and HYOSCYAMINE." }, { "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen, Class II (IVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen)", "output": "IVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen described as molecular assay reagents used in immunological tests to determine class II human leukocyte antigens, a group of cell-surface proteins of the D region coded in three different loci, named DR, DQ, and DP, of the major histocompatibility complex class II genes. These tests are mostly used to match donor and recipient tissues before transplants (e.g., kidney, bone marrow)." }, { "input": "Concept: POLAND (Central European country)", "output": "something described as a country in central Europe, east of Germany. The capital is Warsaw." }, { "input": "Concept: Peritoneal Dialysis Units (Electromechanical Devices)", "output": "something described as devices designed to remove metabolic wastes through selective diffusion across the peritoneum by controlling the flow of a specially designed solution (i.e., a dialysate) into and out of the abdominal cavity (i.e., peritoneal dialysis). These devices consist of a machine that performs automated dialysis cycles, typically while the patient sleeps, by controlling the flow of dialysate. Peritoneal dialysis units infuse and remove dialysate by means of a catheter and a sterile disposable tubing system. A temporary catheter, or more frequently a permanently implanted abdominal catheter, provides access to the peritoneal cavity. Peritoneal dialysis is used less frequently than hemodialysis, it is especially indicated for patients who are unable to tolerate hemodialysis (e.g., the elderly, and patients with diabetes and/or other vascular cardiovascular conditions)." }, { "input": "Concept: SIQ-JR - Killing Myself Would Solve Problem (Intellectual Product)", "output": "something described as suicidal Ideation Questionnaire-Junior (SIQ-JR) I thought that killing myself would solve my problems." }, { "input": "Concept: Study Day of Clinical Events (Temporal Concept)", "output": "Temporal Concept described as the day that a clinical event occurs." }, { "input": "Concept: Claudin 3 (Claudins)", "output": "Biologically Active Substance described as a ubiquitously-expressed claudin subtype that acts as a general barrier-forming protein in TIGHT JUNCTIONS. Elevated expression of claudin-3 is found in a variety of tumor cell types, suggesting its role as a therapeutic target for specific ANTINEOPLASTIC AGENTS." }, { "input": "Concept: juvenile neuronal ceroid lipofuscinosis (Gene Mutation)", "output": "Gene Mutation described as this gene plays a role in endosome and lysosome transport." }, { "input": "Concept: collateral eminence of the lateral ventricle (Region of wall of lateral ventricle)", "output": "Internal anatomical feature, NOS described as a surface feature of the occipital horn of the lateral ventricle in the human. Defined on the basis of dissection it is a swelling in the lateral wall of the ventricle next to the hippocampal formation. It is continuous with the flatter collateral trigone. It is caused by the invagination of the collateral sulcus. It's size depends on the depth of that sulcus, so it is not always present ( Wikipedia )." }, { "input": "Concept: retinoic acid syndrome (Drug-related disorder)", "output": "Poisoning and toxicity described as a syndrome observed in patients with acute promyelocytic leukemia treated with all-trans retinoic acid. It is characterized by weight gain, dyspnea, pleural and pericardial effusions, leukocytosis, and renal failure." }, { "input": "Concept: down regulation of interleukin-6 biosynthetic process (regulation of interleukin-6 biosynthetic process)", "output": "regulation of interleukin-6 biosynthetic process described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." }, { "input": "Concept: PQL04-Hard Explain Illness to People (PedsQL Neuromuscular Module Version 3.0 Parent Report for Teen Questionnaire Question)", "output": "Intellectual Product described as pediatric Quality of Life Neuromuscular Module Version 3.0 Parent Report for Teen (PedsQL Neuromuscular Module Version 3.0 Parent Report for Teen) In the past one month, how much of a problem has this been for your teen: It is hard for my child to explain his or her illness to other people." }, { "input": "Concept: Metalloproteinases, Tolloid-Like (Matrix Metalloproteinases, Secreted)", "output": "something described as a family of metalloproteases that are related to the DROSOPHILA protein tolloid, which is a gene product necessary for dorsal-ventral patterning in early Drosophila embryogenesis. Many members of the group may play a significant role in intercellular signaling." }, { "input": "Concept: JTcB - Bazett's Correction Formula (ECG Measurement)", "output": "Quantitative Concept described as a formula which takes into account the physiologic shortening of the JT interval which occurs as the heart rate increases, permitting comparison of the JT interval across a range of rates. It is mathematically defined as: JTcB = JT/SqRootRR(seconds) and theoretically corrects the JT interval to that which would be observed at a heart rate of 1 cycle per second." }, { "input": "Concept: myotonic cataract (Cataract associated with other syndromes)", "output": "something described as a cataract occurring as a sequela of myotonic dystrophy." }, { "input": "Concept: axolemma (Layer of plasma membrane)", "output": "neuron projection membrane described as plasma membrane that surrounds the cytoplasm and the organelles of an axon." }, { "input": "Concept: unidirectional conjugation (conjugation)", "output": "Cell Function described as the process of unidirectional (polarized) transfer of genetic information involving direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types. Examples of this process are found in prokaryotes." }, { "input": "Concept: L-histidine transmembrane transporter activity (aromatic amino acid transmembrane transporter activity)", "output": "L-amino acid transmembrane transporter activity described as enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid." }, { "input": "Concept: MHC Class II Staining Method (Immunohistochemistry)", "output": "Laboratory Procedure described as an immunohistochemical technique used to detect the presence of class II major histocompatibility complex antigens in a tissue sample." }, { "input": "Concept: Threonine dehydratase (Ammonia-Lyases)", "output": "Enzymes described as a pyridoxal-phosphate protein that catalyzes the deamination of THREONINE to 2-ketobutyrate and AMMONIA. The role of this enzyme can be biosynthetic or biodegradative. In the former role it supplies 2-ketobutyrate required for ISOLEUCINE biosynthesis, while in the latter it is only involved in the breakdown of threonine to supply energy. This enzyme was formerly listed as EC 4.2.1.16." }, { "input": "Concept: jobs (OCCUPATION AND PROFESSIONS: GENERAL TERMS)", "output": "snomed international described as conceptually broad term referring to work specialties as defined by duties and required skills. Use a more specific term if possible." }, { "input": "Concept: ostium atrioventriculare commune (Congenital Heart Defects)", "output": "Endocardial Cushion Defects described as a ventricular septal defect that involves the inlet of the right ventricular septum immediately inferior to the AV valve apparatus." }, { "input": "Concept: Government Funding (Governmental or Regulatory Activity)", "output": "Governmental or Regulatory Activity described as fiscal support from governmental organizations." }, { "input": "Concept: Thiethylperazinum (phenothiazine)", "output": "Piperazine derivative described as a dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness." }, { "input": "Concept: Antibody MIB-1 Staining Method (Immunohistochemistry)", "output": "Laboratory Procedure described as an immunohistochemical technique used to quantify the percent of cells in a tissue sample that can react with the monoclonal antibody MIB-1. Antibody MIB-1 recognizes antigen KI-67 protein, which is a nuclear protein that is exclusively expressed by proliferating cells." }, { "input": "Concept: fimbrial; cyst (Disease or Syndrome)", "output": "Cyst described as a cyst (CYSTS) near the OVARY, derived from anomalies of the FALLOPIAN TUBES or the BROAD LIGAMENT. The paramesonephric type consists of ciliated cells similar to the oviduct epithelium. The mesonephric type consisted of an epithelium with minimally surface structures. They can be found on the thin oviduct (paratubal cysts) or near its fimbriated end (hydatid of Morgagni)." }, { "input": "Concept: Chemokine (C-X-C Motif) Ligand 11 Measurement (Laboratory Procedure)", "output": "something described as a measurement of the chemokine (C-X-C motif) ligand 11 in a biological specimen." }, { "input": "Concept: 7q Deletion (Chromosome 7 Abnormality)", "output": "Cell or Molecular Dysfunction described as a cytogenic abnormality that refers to loss of all or part of the long arm of chromosome 7 (7q). It is associated with the development of chronic myelomonocytic leukemia with eosinophilia, refractory anemia with excess blasts, refractory anemia with multilineage dysplasia, and refractory anemia with multilineage dysplasia and ringed sideroblasts." }, { "input": "Concept: SAMOTOLISIB (Protein Kinase Inhibitors)", "output": "Organic Chemical described as an orally bioavailable, small molecule inhibitor of certain class I phosphoinositide 3-kinase (PI3K) isoforms and mammalian target of rapamycin kinase (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Samotolisib inhibits both certain PI3K isoforms and mTOR in an ATP-competitive manner which may inhibit both the PI3K/mTOR signaling pathway in and proliferation of tumor cells overexpressing PI3K and/or mTOR. The PI3K/mTOR pathway is upregulated in a variety of tumor cells and plays a key role in promoting cancer cell proliferation, and survival, motility and resistance to chemotherapy and radiotherapy. mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent fashion; therefore, this agent may be more potent than an agent that inhibits either PI3K or mTOR alone. In addition, LY3023414 may inhibit DNA-dependent protein kinase (DNA-PK), thereby inhibiting the ability of tumor cells to repair damaged DNA. DNA-PK is activated upon DNA damage and plays a key role in repairing double-stranded DNA breaks." }, { "input": "Concept: IPA0210 (IPAQ Long Last 7 Days Telephone Format Version Questionnaire Question)", "output": "IPAQ Long Last 7 Days Telephone Format Version Questionnaire Question described as international Physical Activity Questionnaire (November 2002) - Long Last 7 Days Telephone Format - During the last 7 days, on how many days did you bicycle to go from place to place?" }, { "input": "Concept: regulation of microtubule anchoring at centrosome (regulation of microtubule cytoskeleton organization)", "output": "Cell Function described as any process that modulates the frequency, rate or extent of microtubule anchoring at centrosome." }, { "input": "Concept: Sex-Determining Region Y-Box 11 Positive (Laboratory or Test Result)", "output": "Laboratory or Test Result described as an indication that SOX11 expression has been detected in a sample." }, { "input": "Concept: Have Other Symptoms (Intellectual Product)", "output": "something described as a question about whether an individual has or had other symptoms." }, { "input": "Concept: undef.taping srvc narr req'd (Taping services)", "output": "Health Care Activity described as any elsewhere undefined taping service, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com." }, { "input": "Concept: Elevators, Uterine (Urogenital device)", "output": "Urogenital device described as instruments intended to be inserted into the uterus to lift and manipulate the uterus." }, { "input": "Concept: Neoplasm of esophagus (Tumor of esophagus, stomach and duodenum)", "output": "Head and Neck Neoplasms described as a benign or malignant neoplasm involving the esophagus." }, { "input": "Concept: cytochrome P450 dependent 12,13beta-epoxy-beta-amyrin hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)", "output": "something described as catalysis of the reaction: 12,13beta-epoxy-beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P)." }, { "input": "Concept: adult diffuse mixed cell lymphoma, stage III (Ann Arbor Stage III Aggressive Adult Non-Hodgkin Lymphoma)", "output": "Neoplastic Process described as stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8134\" active clinical trials using this agent." }, { "input": "Concept: Paullinia cupana, homeopathic preparation (Organic Chemical)", "output": "Homeopathic remedies letter P described as guarana, Brazilian coca." }, { "input": "Concept: Enterobacter muelleri (Bacterium)", "output": "something described as any bacterial organism that can be assigned to the species Enterobacter asburiae." }, { "input": "Concept: Wound stick (Type of drug preparation)", "output": "Type of drug preparation described as solid sterile single-dose preparation, usually rod-shaped or conical, consisting of active substance(s) dissolved or dispersed in a suitable basis that may dissolve or melt at body temperature, intended to be inserted into wounds." }, { "input": "Concept: Extracellular Matrix Degradation (Cell Function)", "output": "Cell Function described as extracellular Matrix Degradation consists of conjugation, transport, oxidation, and/or proteolysis of the supporting meshwork-like network of fibers and substances in the extracellular space or basement membrane to which cells adhere and that promotes cell proliferation. Extracellular Matrix is broken down during normal physiological and disease processes such as bone remodeling, embryogenesis, cancer, and arthritis." }, { "input": "Concept: Progressive hypotrichosis (Hair)", "output": "Decreased hair growth described as progressively reduced or lacking hair growth." }, { "input": "Concept: fast state (Finding)", "output": "Personal Behavior described as abstaining from all food." }, { "input": "Concept: Aptitude (Mental Process)", "output": "Mental Process described as the ability to acquire general or special types of knowledge or skill." }, { "input": "Concept: Cytochrome P450 2A5 (mouse protein)", "output": "mouse protein described as mouse cytochrome P450 2a5 protein (494 aa, 57 kD) is encoded by the mouse Cyp2a5 gene. This enzyme is an unspecific, membrane-bound, monooxygenase located in the endoplasmic reticulum. It catalyzes the metabolism of a variety of substrates including fatty acids, steroids and xenobiotics." }, { "input": "Concept: Negative Regulation of Cytolytic Process (pathologic cytolysis)", "output": "something described as any process that decreases the frequency, rate or extent of cytolysis." }, { "input": "Concept: serum spreading factor (Gene or Genome)", "output": "Extracellular Matrix Protein Gene described as this gene promotes the attachment and spreading of cells and plays a role in the regulation of cell-matrix interactions." }, { "input": "Concept: Protease, Ca2+-Activated (Peptide Hydrolases)", "output": "caspase described as an intracellular, non-lysosomal enzyme." }, { "input": "Concept: ALL3 c.964G>A (PAX5 Gene Mutation)", "output": "PAX5 Gene Mutation described as a nucleotide substitution at position 964 of the coding sequence of the PAX5 gene where guanine has been mutated to adenine." }, { "input": "Concept: International unit/square metre (IU per unit area)", "output": "Unit of Dose Calculation described as a dose calculation unit expressed as a number of arbitrary units of biological activity (International Units) of substance per square meter of body surface area." }, { "input": "Concept: FAC00535 (FACT-B Version 4 Questionnaire Question)", "output": "something described as functional Assessment of Cancer Therapy-Breast Version 4 (FACT-B Version 4) Additional Concerns: I am bothered by a change in weight." }, { "input": "Concept: negative regulation of transcription regulatory region DNA binding (Molecular Function)", "output": "regulation of transcription regulatory region DNA binding described as any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding." }, { "input": "Concept: uL/kg/day (Quantitative Concept)", "output": "Quantitative Concept described as a unit of volume expressed as a number of microliters of the constituent per kilogram of weight per day." }, { "input": "Concept: Radiation oncology (Radiology Specialty)", "output": "something described as a subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer." }, { "input": "Concept: Platelet Aggregometry Mean Amplitude (Hematologic Tests)", "output": "Hematologic Tests described as an average of the measurements of the magnitude of the platelet aggregation in a sample." }, { "input": "Concept: Have you, during the past week, been bothered by abdominal (stomach) aches (Intellectual Product)", "output": "Clinical or Research Assessment Question described as a question about whether an individual is or was bothered by abdominal (stomach) aches." }, { "input": "Concept: Tumor Necrosis Factor Activation (Cytokine Signaling Process)", "output": "Physiologic Function described as any process which promotes expression of tumor necrosis factors, their subsequent secretion, binding to cognate receptors and intracellular signaling, and results in promoting insulin resistance, fever and macrophage phagocytosis, stimulating the hypothalmic-pituitary-adrenal axis and acute phase responses, and suppressing appetite. This process is involved in coordinating systemic responses to pathogenic infection." }, { "input": "Concept: PerformedActivity.negationReason (Intellectual Product)", "output": "Intellectual Product described as the text and/or code that describes why an activity did not occur. EXAMPLE(S): forgot to ask, sample lost OTHER NAME(S): NOTE(S):" }, { "input": "Concept: Biological Agent Detection Kits (Detection Kits)", "output": "something described as detection kits designed to detect and identify biological agents, such as bacteria and virus pathogens and/or toxins. These kits are based on technologies similar to those of clinical laboratory analyzers (e.g., immunoassays performed using test strips with antibodies to specific agents). Typically, a sample is obtained with a swab and mixed with a buffer and then dropped in the test device that displays the results (either positive or negative) within a few minutes.Test strips for most common biothreats are available, including anthrax, ricin, plague (Yersinia pestis), botulinum toxin, tularemia (Francisella tularensis), and brucella. Biological agent detection kits permit in situ screening for unknown biological agents; however, the results should be verified with further laboratory tests. They are used by healthcare workers, rescuers, firefighters, and military personnel for rapid detection in contaminated or potentially contaminated areas." }, { "input": "Concept: single-species biofilm formation in or on host organism (Organism Function)", "output": "adhesion of symbiont to host described as a process in which microorganisms of the same species attach to and grow in or on a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the microorganisms' growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." }, { "input": "Concept: Mycoplasmataceae Freundt 1955 (Approved Lists 1980) emend. Tully et al. 1993 (Tenericutes)", "output": "Bacteria, Anaerobic described as a taxonomic family of parasitic and pathogenic bacterium, which require sterols to grow, in the phylum Tenericutes that includes the genera Mycoplasma and Ureaplasma." }, { "input": "Concept: CSS03-Preparatory Acts/Behavior, Descr (Intellectual Product)", "output": "something described as columbia-Suicide Severity Rating Scale Baseline/Screening Version Phase 1 Study - Description of preparatory acts or behavior." }, { "input": "Concept: Dyssegmental dysplasia with glaucoma syndrome (Disease or Syndrome)", "output": "Congenital anomaly of spine described as this syndrome is characterized by Kniest dysplasia, spine abnormalities and severe dwarfism. Glaucoma has also been reported. The syndrome has been described in two unrelated children" }, { "input": "Concept: nwbrn atchmnt asistnce ea.15 (Parenting education and/or skills training)", "output": "Childrearing Care described as facilitating the development of an affective, enduring relationship between infant and parent" }, { "input": "Concept: Insertion Method of Administration (Functional Concept)", "output": "Functional Concept described as the technique of administration of a pharmaceutical product by placing it into a body cavity, lesion, wound etc." }, { "input": "Concept: GI arteriovenous malformation (Vascular anomalies congenital NEC)", "output": "Vascular anomalies congenital NEC described as an anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the gastrointestinal tract. []" }, { "input": "Concept: Blepharoptosis, myopia, ectopia lentis syndrome (Disease or Syndrome)", "output": "Autosomal dominant hereditary disorder described as this syndrome has characteristics of bilateral congenital blepharoptosis, ectopia lentis and high myopia. It has been described in three members of one family (in a mother and her two daughters). Transmission appears to be autosomal dominant." }, { "input": "Concept: Minute Times Mole per Milliliter (Measurement Unit Description)", "output": "Quantitative Concept described as minutes times moles per milliliter." }, { "input": "Concept: Occult Lung Adenocarcinoma (Neoplastic Process)", "output": "Neoplastic Process described as a lung adenocarcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed." }, { "input": "Concept: cellular response to caloric restriction (Cell Function)", "output": "Cellular Stress Response described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a of caloric restriction, insufficient food energy intake." }, { "input": "Concept: Initial Volume of Distribution Normalized by Dose (Quantitative Concept)", "output": "Quantitative Concept described as the initial volume of distribution for a substance administered by bolus intravascular dosing divided by the dose." }, { "input": "Concept: Hemophilius parainfluenzae (Bacterium)", "output": "something described as any bacterial organism that can be assigned to the species Haemophilus parainfluenzae." }, { "input": "Concept: Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 1 Gene (Transferase Gene)", "output": "Gene or Genome described as this gene plays a role in heparan sulfate metabolism." }, { "input": "Concept: Left pleural sac (Body Part, Organ, or Organ Component)", "output": "Pleural sac described as pleural sac, which surrounds the left lung. Examples: There is only one left pleural sac." }, { "input": "Concept: regulation of cell pH reduction (regulation of intracellular pH)", "output": "regulation of intracellular pH described as any process that modulates the frequency, rate, or extent of a process that reduces the internal pH of a cell." }, { "input": "Concept: ESRSA1-Rigidity: Neck (ESRS-A Clinical Classification Question)", "output": "Intellectual Product described as extrapyramidal Symptom Rating Scale-Abbreviated (ESRS-A) Parkinsonism, Rigidity: Neck." }, { "input": "Concept: Complement C3c (Complement 3)", "output": "Complement 3 described as a 206-amino-acid fragment in the alpha chain (672-1663) of C3b. It is generated when C3b is inactivated (iC3b) and its alpha chain is cleaved by COMPLEMENT FACTOR I into C3c (749-954), and C3dg (955-1303) in the presence COMPLEMENT FACTOR H." }, { "input": "Concept: R1 Cooling Gel Plus R2 Moisturizing/Sun Protecting Lotion (Pharmacologic Substance)", "output": "something described as a skin care treatment system consisting of a cytokine-containing milk-based cooling gel and a cytokine-containing milk-based soothing lotion with hydrating and potential protective activity against radiation-induced dermatitis. Application of the R1 cooling gel immediately upon radiation treatment may hydrate the skin, provide cooling relief, and may protect the skin against radiation-induced dermatitis. The subsequent application of the R2 lotion moisturizes the skin while also protecting the skin against inflammation. In addition, R2 contains avobenzone, homosalate, octinoxate and octocrylene, which exert UVA and UVB skin protective activity." }, { "input": "Concept: LVINVIND (Finding)", "output": "Finding described as an indication as to whether lymphovascular invasion by tumor cells has occurred." }, { "input": "Concept: Stage III Adult Non-Hodgkin's Lymphoma (Neoplastic Process)", "output": "something described as stage III is divided into stages III, IIIE, IIIS, and IIIE+S. In stage III, cancer is found in one or more lymph node groups above and below the diaphragm (the thin muscle below the lungs that helps breathing and separates the chest from the abdomen). In stage IIIE, cancer is found in lymph node groups above and below the diaphragm and outside the lymph nodes in a nearby organ or area. In stage IIIS, cancer is found in lymph node groups above and below the diaphragm and in the spleen. In stage IIIE+S, cancer is found in lymph node groups above and below the diaphragm, outside the lymph nodes in a nearby organ or area, and in the spleen." }, { "input": "Concept: CSS01-First Attempt Damage (C-SSRS Baseline Questionnaire Question)", "output": "C-SSRS Baseline Questionnaire Question described as columbia-Suicidality Severity Rating Scale Baseline (C-SSRS Baseline) Initial/first actual attempt lethality/medical damage." }, { "input": "Concept: BRACHYCEPHALOFRONTONASAL DYSPLASIA (Frontonasal dysplasia sequence)", "output": "Disease or Syndrome described as a rare genetic disease with characteristics of hypertelorism with facial features that can closely resemble craniofrontonasal dysplasia, such as prominent forehead, widow's peak, heavy and broad eyebrows, long palpebral fissures, ptosis, high and broad nasal bridge, short nose, low-set ears, natal teeth, thin upper lip and a grooved chin. Limb features include fifth-finger clinodactyly, pes adductus, mild interdigital webbing. Urogenital features include bilateral cryptorchidism and shawl scrotum in males. Other manifestations include umbilical hernia/omphalocele and cardiac defects. Psychomotor development is normal." }, { "input": "Concept: EIF4A1 wt Allele (EIF4A1 gene)", "output": "something described as human EIF4A1 wild-type allele is located in the vicinity of 17p13 and is approximately 6 kb in length. This allele, which encodes eukaryotic initiation factor 4A-I, plays a role in translation initiation." }, { "input": "Concept: alpha-adrenergic receptor (G-Protein-Coupled Receptors)", "output": "G-Protein-Coupled Receptors described as one of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation." }, { "input": "Concept: Voeslau aqua / water from Voeslau mineral springs (Pharmacologic Substance)", "output": "Inorganic Chemical described as water from Voeslau, Austria mineral springs." }, { "input": "Concept: MSONGO (Event Occurrence Indicator)", "output": "something described as an indication or description that a microbiology susceptibility assessment is continuing." }, { "input": "Concept: Biopsy of Brain (Biopsy)", "output": "Central nervous system histopathology procedures described as removal of brain tissue for microscopic examination." }, { "input": "Concept: GORDONIA BRONCHIALIS (Gordonia Bacterium)", "output": "Gordonia Bacterium described as a species of aerobic, Gram positive, coryneform bacteria assigned to the phylum Actinobacteria. This species is catalase positive, slightly acid fast, nonmotile and contains lipoparabinomannan like lipoglycans in the cell wall. G. bronchialis is an opportunistic pathogen, causing infection at medical device implantation sites and wound sites in surgical patients." }, { "input": "Concept: equatorial microtubule organization (microtubule cytoskeleton organization)", "output": "Cell Function described as a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins at the midpoint of a cell." }, { "input": "Concept: Grade 4 Tracheal Fistula, CTCAE (Tracheal Fistula, CTCAE)", "output": "something described as life-threatening consequences; urgent intervention indicated" }, { "input": "Concept: PREGNENOLONE (P [Preparations])", "output": "something described as a 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS." }, { "input": "Concept: Oxygen supply absent (Pathologic Function)", "output": "Hypoxia described as the absence of oxygen delivery to body tissue." }, { "input": "Concept: IVD Test Reagent/Kits, Immunoassay, Autoimmune, Neurologic, Antiganglioside Antibody, GD1b (IVD Test Reagent/Kits, Immunoassay, Autoimmune, Neurologic, Antiganglioside Antibody)", "output": "IVD Test Reagent/Kits, Immunoassay, Autoimmune, Neurologic, Antiganglioside Antibody described as immunoassay reagents intended to perform qualitative and/or quantitative analyses of a sample of body fluids (e.g., serum) to determine antibodies to the disialoganglioside acid (GD1b antibodies). These antibodies are associated to neuropathies, particularly to chronic sensory ataxic neuropathy." }, { "input": "Concept: Recurrent Glioma (Recurrent Primary Central Nervous System Neoplasm)", "output": "something described as the reemergence of a glioma after a period of remission." }, { "input": "Concept: NM 005228.3:c.2234 2236delAGG (Cell or Molecular Dysfunction)", "output": "Cell or Molecular Dysfunction described as a deletion of three nucleotides from the coding sequence of the EGFR gene from position 2234 through 2246." }, { "input": "Concept: Providing riboflavin based on suboptimal food or fluid intake, iatrogenic deficiency or medical diagnosis. (vitamin therapy)", "output": "something described as providing riboflavin based on suboptimal food or fluid intake, iatrogenic deficiency or medical diagnosis." }, { "input": "Concept: O-Acetyltransferase, Chloramphenicol (Genes, Reporter)", "output": "Amino Acid, Peptide, or Protein described as an enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28." }, { "input": "Concept: Stage III Carcinoma of the Nasal Cavity (Neoplastic Process)", "output": "something described as stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate. T1: Tumor restricted to any one subsite, with or without bony invasion. T2: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis." }, { "input": "Concept: IPAQ Long Last 7 Days Telephone Format Version - Sitting Weekday Minutes per Day (IPAQ Long Last 7 Days Telephone Format Version Questionnaire Question)", "output": "Intellectual Product described as international Physical Activity Questionnaire (November 2002) Long Last 7 Days Telephone Format (IPAQ Long Last 7 Days Telephone Format Version) During the last 7 days, how much time did you usually spend sitting on a weekday?: Minutes per day." }, { "input": "Concept: Posteroventral cochlear nucleus (Body Part, Organ, or Organ Component)", "output": "Body Part, Organ, or Organ Component described as one of three cochlear nuclei identified by dissection and Nissl stain. It and the others, the anteroventral cochlear nucleus and the dorsal cochlear nucleus, form a protrusion on the lateral surface of the medulla where they are entered by the cochlear component of the vestibulocochlear nerve and overlaid by the cerebellar flocculus. They are found in the human ( Moore-2004 ), the macaque ( Dubach-2008 ), the rat ( Swanson-2004 ) and the mouse ( Hof-2000 ). The boundary between the anteroventral and the posteroventral nuclei is less distinct in humans than in the other species ( Moore-2004 ). The cochlear nuclei are classified as part of the subcortical auditory system in the Functional CNS Model - Rat ( Swanson-2004 )." }, { "input": "Concept: PASI0122 (PASI Clinical Classification Question)", "output": "PASI Clinical Classification Question described as psoriasis Area and Severity Index (PASI) Lower Extremities (L): Erythema (E)." }, { "input": "Concept: DNA replication-dependent nucleosome assembly (nucleosome assembly)", "output": "DNA replication-dependent nucleosome organization described as the formation of nucleosomes on newly replicated DNA, coupled to strand elongation." }, { "input": "Concept: Rhizomelic leg shortening (Anatomical Abnormality)", "output": "Anatomical Abnormality described as disproportionate shortening of the proximal segment of the leg (i.e. the femur)." }, { "input": "Concept: 10: 93673716-93779349 (Chromosome 10 Physical Location)", "output": "something described as physical location of BTAF1_Gene" }, { "input": "Concept: Balearic islands (Islands in region of Spain)", "output": "something described as lands that are part of Spain." }, { "input": "Concept: Lymphoma by Ann Arbor Stage (Neoplastic Process)", "output": "Neoplastic Process described as an anatomic stage for Hodgkin and non-Hodgkin lymphomas based on the Ann Arbor classification criteria." }, { "input": "Concept: USIDNET (Professional or Occupational Group)", "output": "Professional or Occupational Group described as a research consortium established to advance scientific research in the primary immune deficiency diseases (PIDD)." }, { "input": "Concept: C17orf41 (Hydrolase Gene)", "output": "Gene or Genome described as this gene is involved in the DNA damage response." }, { "input": "Concept: Lymphocyte antigen CD106 (Amino Acid, Peptide, or Protein)", "output": "Amino Acid, Peptide, or Protein described as cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation." }, { "input": "Concept: ventral part of the suprachiasmatic nucleus (Structure of suprachiasmatic nucleus)", "output": "something described as one of two divisions of the suprachiasmatic nucleus as demonstrated by Nissl stain in the macaque ( Paxinos-2009 ), rat ( Swanson-2004 ) and mouse ( Dong-2004 ). It is distinguishable by failure to stain for vasopressin in the human, but not by Nissl stain ( Saper-2012 ). The other is the doral part of the suprachiasmatic nucleus. The other is the shell of the suprachiasmatic nucleus." }, { "input": "Concept: Coarsened hepatic echotexture (Abnormal liver sonography)", "output": "something described as the appearance of the liver in sonographic images is normally uniform. This term applies when there is an irregular or non-uniform appearance of the liver parenchyma in liver sonography. []" }, { "input": "Concept: body morphogenesis (Morphogenesis)", "output": "Morphogenesis described as the process in which the anatomical structures of the soma are generated and organized." }, { "input": "Concept: Intermediate mesoderm (Mesoderm)", "output": "Region of intra-embryonic mesoderm described as a type of intraembryonic mesoderm, formed from migrating cells in the primitive streak during gastrulation and located between the paraxial mesoderm and lateral mesoderm, that contributes to the development of the urogenital system." }, { "input": "Concept: TUG (Diagnostic Procedure)", "output": "something described as timed Up and Go (TUG) (Podsiadlo D, Richardson S. The Timed 'Up & Go': a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991; 39:142-148)." }, { "input": "Concept: WW Domain Binding Protein 1-Like (Amino Acid, Peptide, or Protein)", "output": "something described as WW domain binding protein 1-like (342 aa, ~38 kDa) is encoded by the human WBP1L gene. This protein may be involved in binding to heme." }, { "input": "Concept: chlorhexidine (ANTIINFECTIVES, OPHTHALMOLOGIC AND OTOLOGIC)", "output": "Allergen class described as a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent." }, { "input": "Concept: Catheters, Central Venous, General-Purpose (catheter device)", "output": "catheter device described as a venous catheter positioned with the tip in the proximal third of the superior vena cava, the right atrium, or the inferior vena cava." }, { "input": "Concept: CDISC Questionnaire COMM Test Name Terminology (CDISC Questionnaire Terminology)", "output": "Intellectual Product described as current Opioid Misuse Measure test name." }, { "input": "Concept: Cholesteryl Ester Transfer Protein, Plasma wt Allele (Gene or Genome)", "output": "something described as human CETP wild-type allele is located within 16q21 and is approximately 22 kb in length. This allele, which encodes cholesteryl ester transfer protein, is involved in the regulation of cholesteryl ester transfer, which is critical to the processes of cholesterol metabolism and homeostasis. Aberrations in the gene may affect atherosclerosis susceptibility." }, { "input": "Concept: 14 kDa Laminin-Binding Protein (Amino Acid, Peptide, or Protein)", "output": "Biologically Active Substance described as galectin-1 (135 aa, ~15 kDa) is encoded by the human LGALS1 gene. This protein may play a role in modulating cell-cell and cell-matrix interactions and may regulate apoptosis, cell proliferation and cell differentiation." }, { "input": "Concept: Minociclinum (Antibiotic)", "output": "Tetracycline Antibiotics described as a kind of antibiotics" }, { "input": "Concept: CD24 Gene (Gene or Genome)", "output": "Genes, Regulator described as this gene is involved in the immune responsiveness of B-cells." }, { "input": "Concept: Bipolar uncorrected XYZ lead system (Lead Placement)", "output": "Lead Placement described as an electrocardiogram (ECG) lead placement whereby the X+ lead is placed at the right mid-axillary line at the 4th intercostal space, X- at the left mid-axillary line at the 4th intercostal space, Y+ at the proximal left leg, Y- at the superior aspect of the manubrium, Z+ at the direct posterior to Z- and Z- at the 4th intercostal space at the left sternal margin." }, { "input": "Concept: ED1-Understand/Follow Directions (Intellectual Product)", "output": "something described as expanded Disability Rating Scale - Postacute Interview Caregiver Version (Expanded DRS-PI Caregiver Version) Can [name] understand, remember, and follow directions?" }, { "input": "Concept: Polyethylene Glycol Recombinant Endostatin (Pharmacologic Substance)", "output": "Pharmacologic Substance described as a formulation containing recombinant endostatin attached to polyethylene glycol (PEG), with potential anti-angiogenic and antineoplastic activities. Endostatin, a 20 kDa C-terminal proteolytic fragment of collagen XVIII, induces microvascular endothelial cell apoptosis and inhibits endothelial proliferation and angiogenesis, which may result in a reduction of tumor cell growth. Modification with PEG extends the circulation half-life of endostatin, improves stability and increases solubility in organic solvents. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C92583\" active clinical trials using this agent." }, { "input": "Concept: APROSENCEPHALY SYNDROME (Disease or Syndrome)", "output": "something described as anomalies of the prosencephalic structures, atelencephaly, and microcephaly in association with congenital heart diseases, preaxial limb malformations, eye abnormalities, and genital and other deformities. The disorder is frequently lethal. Infants who survive are severely retarded. Ring chromosome 13, duplication of the long arm of chromosome 13, and this syndrome share many common clinical features. In the synonym XK syndrome, the letter \"X\" stands for the unreported name of the patient of Garcia and Duncan, and \"K\" for the initial of Lurie's patient." }, { "input": "Concept: limiting medullary lamina of the globus pallidus (Body Part, Organ, or Organ Component)", "output": "something described as white matter at the medial boundary of the medial globus pallidus ( Mai-1997 )." }, { "input": "Concept: Planned Number of Female Subjects (Quantitative Concept)", "output": "Quantitative Concept described as the intended quantity of female subjects." }, { "input": "Concept: BURKHOLDERIA CEPACIA COMPLEX (Burkholderia)", "output": "something described as a non-taxonomic grouping of bacterial species that are phenotypically or genetically similar to the Burkholderia cepacia species." }, { "input": "Concept: prepyriform area (Parahippocampal Gyrus)", "output": "Cerebral basal surface structure described as an area of the olfactory cortex comprising the rostral half of the uncus of the PARAHIPPOCAMPAL GYRUS and the anterior PARAHIPPOCAMPAL GYRUS. It receives major afferents directly from the OLFACTORY BULB." }, { "input": "Concept: Mesenteric Artery (Structure of artery of abdomen)", "output": "something described as arteries which arise from abdominal aorta and supply most of the intestines." }, { "input": "Concept: 4p16.3 (Chromosome band)", "output": "Cell Component described as a chromosome band present on 4p" }, { "input": "Concept: MMS2-Do What This Says to Do (MMSE-2 Standard Version Functional Test Question)", "output": "something described as mini-Mental State Examination 2 Standard Version - Please do what this says to do." }, { "input": "Concept: SLT (Pharmacologic Substance)", "output": "something described as brand name of topical coal tar" }, { "input": "Concept: eukaryotic 43S pre-initiation complex (Cell Component)", "output": "Cell Component described as a protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." }, { "input": "Concept: Facial anomaly (Anatomical Abnormality)", "output": "Abnormality of the head described as an abnormality of the face." }, { "input": "Concept: Dichloromethane (Pharmacologic Substance)", "output": "Hazardous or Poisonous Substance described as a clear, colorless, nonflammable, volatile liquid chlorinated hydrocarbon with a sweet, pleasant smell and emits highly toxic fumes of phosgene when heated to decomposition. Methylene chloride is primarily used as a solvent in paint removers, but is also used in aerosol formulations, as a solvent in the manufacture of pharmaceuticals, as a degreasing agent, in electronics manufacturing and as an ethane foam blowing agent. Inhalation exposure to this substance irritates the nose and throat and affects the central nervous system. Methylene chloride is a possible mutagen and is reasonably anticipated to be a human carcinogen." }, { "input": "Concept: vesicle tethering (cellular component organization)", "output": "Cell Function described as the initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion." }, { "input": "Concept: Bibliotherapies (Therapeutic or Preventive Procedure)", "output": "Rehabilitation therapy described as therapeutic use of literature to enhance expression of feelings, active problem solving, coping, or insight" }, { "input": "Concept: IVD Test Reagent/Kits, Serology, Parasite, Trypanosoma cruzi, Antibody (IVD Test Reagent/Kits, Serology, Parasite)", "output": "IVD Test Reagent/Kits, Serology, Parasite described as serology reagents intended to detect serum antibodies to Trypanosoma cruzi, a species of protozoon of the suborder Trypanosomatina. Trypanosoma cruzi causes Chagas' disease (American trypanosomiasis) in humans, characterized by an erythematous nodule (i.e., chagoma) appearing within a few days at the site of the inoculation. These parasites are transmitted to humans by insects from other humans or from animals (e.g., cats, dogs, rodents)." }, { "input": "Concept: protein maturation by nickel ion transfer (protein maturation)", "output": "Cell Function described as a process that contributes to the delivery of nickel ions to a target protein to facilitate its maturation." }, { "input": "Concept: h*pmol/mL/mg (Measurement Unit Description)", "output": "Measurement Unit Description described as hours times picomoles per milliliter per milligram." }, { "input": "Concept: Desulfotomaculum (BACTERIA AND RICKETTSIAE)", "output": "Bacterium described as a genus of anaerobic bacteria in the family Peptococcaceae, widely distributed in SOIL and the RUMEN of animals. Stains gram-negative but cell wall is gram-positive type." }, { "input": "Concept: Unknown Daily Caloric Intake (Finding)", "output": "Finding described as the daily caloric intake is unknown." }, { "input": "Concept: Cistus (Plant)", "output": "something described as a plant genus of the family CISTACEAE. The common name of rock rose is also sometimes used with the closely related Helianthemum genus (CISTACEAE)." }, { "input": "Concept: ChEH (ether hydrolase activity)", "output": "ether hydrolase activity described as catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol." }, { "input": "Concept: Aggressive Papillary Tumor of the Temporal Bone (Benign neoplasm of ear)", "output": "Neoplasm of the inner ear described as a low-grade papillary epithelial neoplasm (adenocarcinoma) with a slow growth pattern. The endolymphatic duct emerges from the posterior wall of the saccule (of the inner ear) and ends in a blind pouch, the endolymphatic sac. Endolymphatic sac tumors (ELSTs) are known under different names in the literature (Heffner tumor, aggressive papillary middle ear tumor, and low-grade adenocarcinoma of endolymphatic sac origin)." }, { "input": "Concept: 3-formiminopyruvate hydrolase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds)", "output": "something described as catalysis of the reaction: 3-formiminopyruvate + H2O = 3-formylpyruvate + HN3." }, { "input": "Concept: Ten Pack (Quantitative Concept)", "output": "Quantitative Concept described as a product containing ten individual units." }, { "input": "Concept: Materials Testing, Biocompatible (Research Activity)", "output": "evaluation/testing described as evaluation of synthetic or industrial materials intended for use in contact with human tissues." }, { "input": "Concept: (S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase activity (oxidoreductase activity, acting on CH-OH group of donors)", "output": "oxidoreductase activity, acting on CH-OH group of donors described as catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor." }, { "input": "Concept: Coronavirus Nucleocapsid Protein (Amino Acid, Peptide, or Protein)", "output": "Biologically Active Substance described as nucleocapsid proteins from species of the CORONAVIRIDAE virus family." }, { "input": "Concept: atazanavir (Retroviral protease inhibitor)", "output": "Pyridines described as an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS." }, { "input": "Concept: Ectopic Graft (Transplanted tissue)", "output": "Transplanted tissue described as a graft transferred from one organ site to another, within the same individual or between individuals." }, { "input": "Concept: CD40 Ligand Measurement (Laboratory Procedure)", "output": "something described as the determination of the amount of CD40 ligand present in a sample." }, { "input": "Concept: CD72 antigen (Cell Adhesion Molecule Gene)", "output": "Gene or Genome described as this gene plays a role in signal transduction that leads to B-cell differentiation." }, { "input": "Concept: dislocation; septum (Nasal deviation)", "output": "Other and unspecified disorders of nose and nasal sinuses described as positioning of the nasal septum to the right or left in contrast to the normal midline position of the nasal septum." }, { "input": "Concept: Thyroid Gland Mucoepidermoid Carcinoma (Thyroid carcinoma)", "output": "Neoplastic Process described as a primary, low grade carcinoma of the thyroid gland composed of groups of squamoid and mucous cells, surrounded by fibrous tissue. Prominent cystic structures may be present. The clinical course is usually indolent." }, { "input": "Concept: Dibotermin alfa-containing product (Plain bone cements)", "output": "something described as a recombinant form of human bone morphogenetic protein 2 (rhBMP-2), with potential bone remodeling and osteoinductive activities. Following administration, rhBMP-2 induces BMP-2 signaling cascades, which leads to osteoblast differentiation, enhancement of bone repair and formation, and improvement of re-vascularization. This promotes bone healing. BMP-2, a protein belonging to the transforming growth factor beta (TGFb) superfamily of proteins, plays a key role in bone and cartilage formation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C132249\" active clinical trials using this agent." }, { "input": "Concept: Exatecan Mesylate Anhydrous (Organic Chemical)", "output": "Organic Chemical described as the anhydrous, mesylate salt form of exatecan, a semisynthetic, water-soluble derivative of camptothecin, with antineoplastic activity. Upon administration, exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting re-ligation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death." }, { "input": "Concept: rhombomere formation (Organism Function)", "output": "anatomical structure formation involved in morphogenesis described as the process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." }, { "input": "Concept: Complete overdenture (Therapeutic or Preventive Procedure)", "output": "Complete denture, including adjustments described as dentures designed for insertion over one or more remaining teeth, roots, or implants for replacement of all the teeth in the upper (i.e., maxilla) or lower (i.e., mandible) jaw. These dentures are typically consist of a movable, custom-made prosthesis that includes artificial porcelain or resin teeth attached to movable metallic (e.g., titanium) or polymeric (e.g., acrylic) base and attachments that fit on the remaining dental parts, dental implants, and/or the alveolar ridge. Complete overlay dentures are available to replace all natural teeth in the upper or lower jaw." }, { "input": "Concept: tumor; placental site trophoblastic (Trophoblastic Neoplasms)", "output": "Neoplasm of uncertain behavior of female genital organ described as an uncommon variant of CHORIOCARCINOMA. It is composed almost entirely of mononuclear cytotrophoblasts (TROPHOBLASTS). Because its secretion of hCG (CHORIONIC GONADOTROPIN) is low, a large tumor may develop before the hCG can be detected." }, { "input": "Concept: Visual Field Disorder (Disorder by Site)", "output": "something described as visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peripheral vision; may result from eye diseases, optic nerve diseases, visual pathway diseases, occipital lobe diseases, ocular motility disorders, etc; visual disability refers to inability of the individual to perform specific visual tasks, such as reading, writing, orientation, or traveling unaided." }, { "input": "Concept: regulation of macrophage differentiation (Cell Function)", "output": "something described as any process that modulates the frequency, rate or extent of macrophage differentiation." }, { "input": "Concept: Gonioscopies (Special Ophthalmological Services and Procedures)", "output": "Special Ophthalmological Services and Procedures described as examination of the anterior chamber and the iridiocorneal angle using a specialized video camera (gonioscope) and a slit lamp." }, { "input": "Concept: RVD (cell volume homeostasis)", "output": "cell volume homeostasis described as any process that decreases cell volume." }, { "input": "Concept: Physicians; Physician/Osteopath; Nuclear Medicine, In Vivo & In Vitro (Professional or Occupational Group)", "output": "Professional or Occupational Group described as a nuclear medicine physician who specializes in in vivo and in vitro nuclear medicine." }, { "input": "Concept: Care compliance education (Patient counseling education)", "output": "Patient counseling education described as teaching a patient techniques to assist him or her in complying with his or her therapy and/or treatment." }, { "input": "Concept: GPRK6 (G Protein-Coupled Receptor Kinase Gene)", "output": "something described as this gene is involved in signal transduction." }, { "input": "Concept: CTCAE Grade 2 Urticaria (Finding)", "output": "Finding described as urticarial lesions covering 10-30% BSA; oral intervention indicated" }, { "input": "Concept: arcanobacterium (Actinomycetaceae)", "output": "Bacterium described as a genus of facultatively anaerobic, gram-positive bacteria in the family ACTINOMYCETACEAE, order ACTINOMYCETALES. They are obligate parasites of the PHARYNX in humans and farm animals." }, { "input": "Concept: Planned Notification (Notifications)", "output": "Notifications described as an activity that is intended to occur at some point in the context of a particular study or experiment that represents the communication of a message to a recipient. EXAMPLE(S): OTHER NAME(S): NOTE(S):" }, { "input": "Concept: Fingerprintings, DNA (Biometric Identification)", "output": "Forensic Medicine described as a technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population." }, { "input": "Concept: WHODAS 2.0 - 36-ITEM INTERVIEWER (Clinical or Research Assessment Questionnaire)", "output": "Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 - 36-item Version, Interviewer-administered (WHODAS 2.0 - 36-item Version Interviewer-administered) (Reproduced, with permission of WHO, from Measuring Health and Disability: Manual for WHO Disability Assessment Schedule (WHODAS 2.0). Geneva,World Health Organization, 2010 (WHODAS 2.0 36-Item Version, Interviewer-Administered www.who.int/classifications/icf/whodasii/en))." }, { "input": "Concept: health science research (biomedical resource)", "output": "something described as investigation or experimentation aimed at the discovery and interpretation of facts, revision of accepted theories or laws in the light of new facts, or practical application of such new or revised theories or laws in relation to biomedical science and health care." }, { "input": "Concept: zingiberis siccatum/gan jian (Oriental herbs and natural substances letter Z)", "output": "Oriental herbs and natural substances letter Z described as gan jiang" }, { "input": "Concept: EMO108C (Intellectual Product)", "output": "something described as emotion Recognition - Number of disgust stimuli responded to as fear." }, { "input": "Concept: metanephric cortical collecting duct development (cortical collecting duct development)", "output": "cortical collecting duct development described as the process whose specific outcome is the progression of the metanephric cortical collecting duct over time, from its formation to the mature structure. The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex." }, { "input": "Concept: Exocrine Pancreatic Carcinoma pTis TNM Finding v8 (Exocrine Pancreatic Cancer Pathologic Primary Tumor TNM Finding v8)", "output": "Exocrine Pancreatic Cancer Pathologic Primary Tumor TNM Finding v8 described as exocrine pancreatic cancer with a finding of carcinoma in situ. This includes high-grade pancreatic intraepithelial neoplasia (PanIn-3), intraductal papillary mucinous neoplasm with high-grade dysplasia, intraductal tubulopapillary neoplasm with high-grade dysplasia, and mucinous cystic neoplasm with high-grade dysplasia." }, { "input": "Concept: Histone-Lysine N-Methyltransferase 2A/Protein ENL Fusion Protein (Biologically Active Substance)", "output": "Biologically Active Substance described as a fusion protein encoded by the MLL/MLLT1 fusion gene. This protein is comprised of the N-terminal half of the histone-lysine N-methyltransferase MLL protein, including the AT hook DNA binding domain and the DNA methyltransferase domain, fused to almost the entire protein ENL. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C99322\" active clinical trials using this agent." }, { "input": "Concept: mannose trimming involved in glycoprotein ERAD pathway (protein deglycosylation involved in glycoprotein catabolic process)", "output": "protein alpha-1,2-demannosylation described as the removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD)." }, { "input": "Concept: protein storage vacuole organization (vacuole organization)", "output": "something described as a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a protein storage vacuole, a storage vacuole that contains a lytic vacuole." }, { "input": "Concept: Registry Protocol Identifier (Intellectual Product)", "output": "Intellectual Product described as a unique code assigned by a clinical trial registry that identifies a specific protocol." }, { "input": "Concept: Unexpected (Intellectual Product)", "output": "something described as something that is not planned or anticipated." }, { "input": "Concept: Have Adequate Moisture in Mouth (Findings-Based Question)", "output": "Findings-Based Question described as a question about whether an individual currently has adequate moisture in their mouth." }, { "input": "Concept: United States Social Security Administration (United States Government Agencies)", "output": "Organization described as an independent agency within the Executive Branch of the United States Government. It administers a national social insurance program whereby employees, employers, and the self-employed pay contributions into pooled trust funds. Part of the contributions go into a separate hospital insurance trust fund for workers at age 65 to provide help with medical expenses. Other programs include the supplemental social security income program for the aged, blind, and disabled and the Old Age Survivors and Disability Insurance Program. It became an independent agency March 31, 1995. It had previously been part of the Department of Health, Education, and Welfare, later the Department of Health and Human Services." }, { "input": "Concept: Contouring, Body (Reconstructive Surgical Procedures)", "output": "something described as plastic surgery to shape many areas of the body simultaneously. This may include LIPECTOMY or RHYTIDOPLASTY or both." }, { "input": "Concept: steviolbioside glucosyltransferase activity (hexosyltransferase activity)", "output": "something described as catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = stevioside + UDP + H+." }, { "input": "Concept: Ring chromosome 8 syndrome (Chromosome replaced with ring or dicentric)", "output": "Chromosome replaced with ring or dicentric described as a rare chromosomal anomaly from a variable part of chromosome 8. The phenotype of mosaic or non-mosaic supernumerary r(8)/mar(8) ranges from almost normal to variable degrees of minor abnormalities, and growth and mental retardation overlapping with the well-known mosaic trisomy 8 syndrome." }, { "input": "Concept: Personal Narrative (Intellectual Product)", "output": "Intellectual Product described as work consisting of accounts of individual experience in relation to a particular field or of participation in related activities." }, { "input": "Concept: Software Development (Action)", "output": "Action described as the design and writing of computer programs. Software development includes the design of the user interface and the program architecture as well as programming the source code. A somewhat broader scope of computer programming or a specialty of project managing." }, { "input": "Concept: negative regulation of adrenaline uptake (regulation of epinephrine uptake)", "output": "something described as any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of epinephrine into a cell." }, { "input": "Concept: Date of Last Dose (Date in time)", "output": "something described as the date on which the last dose of a specified treatment regiment was administered." }, { "input": "Concept: glutathione S-conjugate-exporting ATPase activity (ATPase-coupled transmembrane transporter activity)", "output": "Molecular Function described as catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out)." }, { "input": "Concept: regulation of protein localization to adherens junction (regulation of protein localization to cell-cell junction)", "output": "Cell Function described as any process that modulates the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." }, { "input": "Concept: positive regulation of protein histidine kinase activity (Molecular Function)", "output": "regulation of protein histidine kinase activity described as any process that increases the frequency, rate or extent of protein histidine kinase activity." }, { "input": "Concept: Gonadal Dysgenesis, 46,XY (46, XY Disorders of Sex Development)", "output": "Sex Chromosome Disorders described as gonadal dysgenesis in an individual with 46.XY karyotype." }, { "input": "Concept: Goniothalamus (Annoneae)", "output": "Plant described as a plant genus of the family ANNONACEAE. Members contain cyclopeptides and styrylpyrones." }, { "input": "Concept: Reticulocyte Corpuscular Hemoglobin Distribution Width (Laboratory Procedure)", "output": "Hemoglobin measurement described as a measurement of the standard deviation of hemoglobin concentrations in reticulocytes, calculated as the standard deviation of hemoglobin content divided by the mean hemoglobin content." }, { "input": "Concept: Ultra-low vision (Finding)", "output": "Finding described as best corrected visual acuity worse than 1.90 logMAR (roughly 20/1590). []" }, { "input": "Concept: Early spermatogenesis maturation arrest (Spermatogenesis maturation arrest)", "output": "Spermatogenesis maturation arrest described as a type of maturation arrest in which only spermatogonia or spermatocytes are found." }, { "input": "Concept: AssociatedBiologicEntity (Entity)", "output": "Organism described as an individual biologic entity connected/linked to another biologic entity. EXAMPLE(S): family member, roommate, nursing home attendant OTHER NAME(S): NOTE(S):" }, { "input": "Concept: Institution Supplementation (Governmental or Regulatory Activity)", "output": "Governmental or Regulatory Activity described as additional support to assist in meeting living costs may be provided by the grantee training institution. This supplement does not require any additional effort from the trainee. Federal funds may not be normally used except by special arrangements and authorization. There are no restrictions on use of private funds." }, { "input": "Concept: Rhizobium etli (Rhizobium)", "output": "Rhizobium described as a species of gram-negative bacteria and nitrogen innoculant of PHASEOLUS VULGARIS." }, { "input": "Concept: Designs, Epidemiological Research (Health Care Evaluation Mechanisms)", "output": "Health Care Evaluation Mechanisms described as the form and structure of analytic studies in epidemiologic research." }, { "input": "Concept: growth cone membrane (Cell Component)", "output": "Cell Component described as the portion of the plasma membrane surrounding a growth cone." }, { "input": "Concept: Take a Positive Attitude Toward Myself (Intellectual Product)", "output": "something described as a question about whether an individual takes a positive attitude towards themselves." }, { "input": "Concept: NCCN-FACT FBRSI-24 Version 2 - I Have a Good Appetite (NCCN-FACT FBRSI-24 Version 2 Questionnaire Question)", "output": "something described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Brain Symptom Index-24 Version 2 - I have a good appetite." }, { "input": "Concept: FHF-2 (Biologically Active Substance)", "output": "Biologically Active Substance described as fibroblast growth factor 13 (245 aa, ~28 kDa) is encoded by the human FGF13 gene. This protein plays a role in the regulation of both the development of the nervous system and microtubule polymerization." }, { "input": "Concept: calcium ion export from cell (calcium ion export)", "output": "calcium ion export described as the directed movement of calcium ions from inside of a cell, across the plasma membrane and into the extracellular region." }, { "input": "Concept: ions (Elementary Particles)", "output": "Chemicals described as an atom or molecule having a positive or negative charge owing to the loss or gain of one or more electrons." }, { "input": "Concept: CHROMATOGRAPHIC SEPARATION, CPK ISOENZYMES (Medical Device)", "output": "Medical Device described as a creatine phosphokinase/creatine kinase or isoenzymes test system is a device intended to measure the activity of the enzyme creatine phosphokinase or its isoenzymes (a group of enzymes with similar biological activity) in plasma and serum. Measurements of creatine phosphokinase and its isoenzymes are used in the diagnosis and treatment of myocardial infarction and muscle diseases such as progressive, Duchenne-type muscular dystrophy." }, { "input": "Concept: Pit, Cell-Membrane Coated (Cardinal cell part)", "output": "Cell Component described as specialized depressions on the cell surface involved in receptor-mediated endocytosis; the visible proteinaceous layer on the cytosolic side of the depression provides the coated appearance." }, { "input": "Concept: calcium-mediated signaling (Second Messenger Systems)", "output": "Ion Transport described as any process that involves the local flux of calcium from the endoplasmic reticulum or sarcoplasmic reticulum to the cytosol. This process is involved in intracellular signaling and in maintaining depolarization of the heart." }, { "input": "Concept: electrophoresis (Laboratory Procedure)", "output": "Electrochemical Techniques described as a laboratory technique that uses an electric current to separate substances, such as proteins or nucleic acids. The size and electrical charge (either positive or negative) of a substance determines how far it moves with the current. Electrophoresis may be used to help diagnosis certain diseases. There are many different types of electrophoresis." }, { "input": "Concept: Recurrent Chromophobe Renal Cell Carcinoma (Neoplastic Process)", "output": "Chromophobe Renal Cell Carcinoma described as the reemergence of chromophobe renal cell carcinoma after a period of remission." }, { "input": "Concept: human papillomavirus virus-like particles conjugated with IR700 dye AU-011 (Antineoplastic Agents)", "output": "Antineoplastic Agents described as a formulation composed of nanoparticles derived from the human papillomavirus (HPV-NPs) and conjugated to the infrared (IR)-activated fluorescent dye IR700 (IR-700), with potential antineoplastic activity. Upon intravitreal injection, the HPV-NPs target and bind to heparan-sulfated proteoglycans (HSPG) expressed by ocular melanoma cells. Upon irradiation with near-IR (NIR) light, the photosensitizer IR700 becomes activated, generates reactive oxygen species (ROS) and selectively damages the melanoma cell membrane, which induces necrosis of the melanoma cells while sparing the surrounding, healthy non-HSPG-expressing tissue, and potentially preserving vision. HSPGs are overexpressed on a variety of cancer cell types." }, { "input": "Concept: PUMP-1 (Metallopeptidase Gene)", "output": "something described as this gene plays a role in proteolysis." }, { "input": "Concept: SDS - Days Lost (Intellectual Product)", "output": "Intellectual Product described as sheehan Disability Scale - On how many days in the last week did your symptoms cause you to miss school or work or leave you unable to carry out your normal daily responsibilities?" }, { "input": "Concept: Abnormal circulating biopterin concentration (Abnormal circulating nitrogen compound concentration)", "output": "something described as a deviation from the normal concentration of biopterin in the blood circulation. []" }, { "input": "Concept: degenerative spinal arthritis (Spondylosis)", "output": "Arthritis described as degenerative arthritis of the spinal column." }, { "input": "Concept: Measurement of carcinoembryonic antigen (Protein measurement)", "output": "Immunologic Tests described as a measurement of the carcinoembryonic antigen in a biological specimen." }, { "input": "Concept: Manufacture Date (Temporal Concept)", "output": "Date in time described as the date and/or time on which a product is made." }, { "input": "Concept: activin receptor binding (Molecular Function)", "output": "Molecular Function described as interacting selectively and non-covalently with an activin receptor." }, { "input": "Concept: cardiac muscle cell action potential involved in contraction (cardiac muscle cell action potential)", "output": "cardiac muscle cell action potential described as an action potential that occurs in a cardiac muscle cell and is involved in its contraction." }, { "input": "Concept: Equal Education (Curricula)", "output": "Curricula described as provision of comparable educational opportunities to all individuals irrespective of race, national origin, religion, sex, socioeconomic status, or ability." }, { "input": "Concept: histone H2A ubiquitination (Molecular Function)", "output": "Molecular Function described as the modification of histone H2A by addition of one or more ubiquitin groups." }, { "input": "Concept: Stage IIIC1 Uterine (including Endometrial) Cancer (Stage IIIC Uterine Corpus Cancer AJCC v8)", "output": "Neoplastic Process described as stage IIIC1 includes: T1-T3, N1/N1mi/N1a, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N1: Regional lymph node metastasis to pelvic lymph nodes. N1mi: Regional lymph node metastasis (greater than 0.2 mm but nor greater than 2.0 mm in diameter) to pelvic lymph nodes. N1a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to pelvic lymph nodes. M0: No distant metastasis." }, { "input": "Concept: Vitamin F (Eicosanoids)", "output": "A [Preparations] described as polyunsaturated fatty acid with 20 carbons and 4 double bonds at the 6th, 9th, 12th and 15th carbons from the methyl end." }, { "input": "Concept: C-terminal protein lipidation (Molecular Function)", "output": "something described as the covalent attachment of a lipid group to the carboxy-terminus of a protein." }, { "input": "Concept: LIM and SH3 protein 1 (Transport Protein Gene)", "output": "something described as this gene is involved in actin-dependent ion transport." }, { "input": "Concept: FIGO Stage I Carcinoma of Fallopian Tube (stage, fallopian tube cancer)", "output": "stage, fallopian tube cancer described as stage I includes: (T1, N0, M0); IA (T1a, N0, M0); IB (T1b, N0, M0); IC (T1c, N0, M0). T1: tumor limited to the fallopian tube(s). T1a: tumor limited to one tube, without penetrating the serosal surface; no ascites. T1b: tumor limited to both tubes, without penetrating the serosal surface; no ascites. T1c: tumor limited to one or both tubes with extension onto or through the tubal serosa, or with malignant cells in ascites or peritoneal washings. N0: no regional lymph node metastasis. M0: no distant metastasis." }, { "input": "Concept: Hydrolases, Glycoside (Enzyme)", "output": "Enzymes described as covering the sugar hydrolases." }, { "input": "Concept: Light, Patchy Or Insufficient Anesthesia (Other Finding)", "output": "something described as a state of consciousness that permits the formation of explicit and implicit memories while under general anesthesia." }, { "input": "Concept: Woringer-Kolopp Disease (Cutaneous/peripheral T-cell lymphoma)", "output": "Lymphoma, T-Cell, Cutaneous described as a distinct variant of mycosis fungoides characterized by the presence of localized patches or plaques with an intraepidermal proliferation of neoplastic cells." }, { "input": "Concept: Compounds, Diazonium (Nitrogen Compounds, Unspecified)", "output": "Azo Compounds described as azo compounds consisting of an aryl or alkyl group that is joined through two nitrogen atoms to an anion (R-N2+X-)." }, { "input": "Concept: GEN1 Gene Mutation (Cell or Molecular Dysfunction)", "output": "Gene Mutant described as a change in the nucleotide sequence of the GEN1 gene." }, { "input": "Concept: Shoulder girdle, NOS (Subdivision of skeletal system of upper limb)", "output": "Chest described as subdivision of skeletal system of upper limb, which is the proximal segment of skeletal system of upper limb and links the skeletal system of free upper limb to the trunk; it is demarcated by the plane of the surface of the glenoid fossa from the free upper limb; together with the skeletal system of free upper limb, it constitutes skeletal system of upper limb. Examples: There is only one pectoral girdle." }, { "input": "Concept: Telemetered Indicator (Finding)", "output": "Indicator described as an indication as to whether the subject(s) were telemetered during the study." }, { "input": "Concept: Densitometer (Gauge or Meter Device)", "output": "Gauge or Meter Device described as a device designed to measure density." }, { "input": "Concept: Left ventricular diastolic dysfunction (Ventricular Dysfunction, Left)", "output": "something described as abnormal function of the left ventricule during left ventricular relaxation and filling." }, { "input": "Concept: HAQ02-Get In and Out of Bed (HAQ-DI Without VAS Questionnaire Question)", "output": "HAQ-DI Without VAS Questionnaire Question described as health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale (HAQ-DI Without VAS) Arising: Are you able to get in and out of bed?" }, { "input": "Concept: Filler (Pharmaceutical Excipient)", "output": "something described as a therapeutically inactive ingredient of a solid pharmaceutical dosage form that is used to increase the volume of the material to accommodate easier processing of the drug and to make it a suitable size for patient consumption Typical fillers include calcium phosphate (also an added source of both minerals), lactose, powder, sucrose powder." }, { "input": "Concept: Dixon MRI (Diagnostic Procedure)", "output": "Diagnostic Procedure described as an imaging method that combines in-phase and out-of-phase echoes to create water-only and fat-only images. This technique is particularly useful in abdominal imaging at 3T." }, { "input": "Concept: Stripe Artifact (Finding)", "output": "Suboptimal Image Reason described as an artifact that appears as stripes within the image." }, { "input": "Concept: negative regulation of spore germination on or near host (Biologic Function)", "output": "negative regulation of development of symbiont on or near host surface described as any process that stops, prevents, or reduces the frequency, rate or extent of spore germination on or near host, which is the physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." }, { "input": "Concept: regulation of peroxisome organisation (regulation of organelle organization)", "output": "something described as any process that modulates the frequency, rate or extent of peroxisome organization." }, { "input": "Concept: Gastrointestinal Absorption Induction (Physiologic Function)", "output": "Physiologic Function described as gastrointestinal Absorption Induction involves initiation of activities of uptake from the intestinal lumen of fluids, solutes, proteins, fats, and other nutrients into the intestinal epithelial cells, blood, lymph, or interstitial fluids." }, { "input": "Concept: Locomotion (Biological Processes)", "output": "something described as self-propelled movement of a cell or organism from one location to another." }, { "input": "Concept: Brachium Pontis (Body Part, Organ, or Organ Component)", "output": "something described as WHITE MATTER consisting of a large bundle of paired fibers originating in the pontine nuclei in the pre pontis and the nucleus reticularis tegmenti pontis projecting to the contralateral cerebral cortex." }, { "input": "Concept: Basic dose form with solid state of matter (Dosage Forms)", "output": "something described as a dose form that displays properties of a solid." }, { "input": "Concept: Plates, Radiographic Image Storage (Radiology/Radiation Therapy Equipment and Supplies)", "output": "Medical Device described as dedicated plates designed for temporary storage of latent images. These devices typically consist of a thin plate of translucent plastic material covered with an excitable compound (e.g., storage phosphor) used for storage of a latent image following exposure of the material to some type of radiation (e.g., x-ray, light). After exposure, the plates are transferred to reading devices that retrieve the information from the latent image and convert it to a digital signal." }, { "input": "Concept: Stage IV Lip and Oral Cavity Cancer (Lip and Oral Cavity Cancer by AJCC v8 Stage)", "output": "Neoplastic Process described as stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone or involves the inferior alveolar nerve, floor of mouth, or skin of face (i.e., chin or nose). T4a (oral cavity): Tumor invades adjacent structures only (e.g., through cortical bone of the mandible or maxilla, or involves the maxillary sinus or skin of face). Note: Superficial erosion of bone/tooth socket (alone) by a gingival primary is not sufficient to classify a tumor as T4. T1: Tumor size 2 cm or less in greatest dimension and 5 mm or less DOI. T2: Tumor size 2 cm or less in greatest dimension, DOI greater than 5 mm and equal or less than 10 mm or tumor greater than 2 cm but 4 cm or less in greatest dimension and 10 mm or less DOI. T3: Tumor size greater than 4 cm or any tumor greater than 10 mm DOI. T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases the internal carotid artery. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(-). N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or larger than 3 cm but not larger than 6 cm in greatest dimension and ENE (-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension, ENE(-). N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE (-); or in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral or bilateral lymph nodes any with ENE(+). M0: No distant metastasis. M1: Distant metastasis." }, { "input": "Concept: DIR (NICHD Terminology)", "output": "NICHD Terminology described as terminology associated with the directionality codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." }, { "input": "Concept: unblinding (Blinded)", "output": "Blinded described as identification of the treatment code of a subject or grouped results in studies where the treatment assignment is unknown to the subject and investigators." }, { "input": "Concept: Ophthalmic (Body organ structure)", "output": "Head described as organ with organ cavity which is connected to the optic nerve. Examples: There are only two eyeballs, the right and the left eyeballs.." }, { "input": "Concept: Human leukocyte antigen HLA-DR6 antigen (HLA-DR Serological Subtypes)", "output": "something described as a broad-specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*13 and DRB1*14 alleles." }, { "input": "Concept: CCID50 (Potency Unit)", "output": "Potency Unit described as a potency unit defined as a minimal dose of infectious material at which preparation causes cytopathic effects (changes in the morphology and metabolism of cell culture cells, indicating cell death, due to suspected infection) in the 50% of the cell culture-containing vessels inoculated with that dilution of infectious material." }, { "input": "Concept: WISE (Signaling Pathway Gene)", "output": "something described as this gene is involved in the negative regulation of bone morphogenic protein signaling." }, { "input": "Concept: BTG Cell Cycle Regulation Pathway (Cell Cycle Regulation Pathway)", "output": "something described as BTG2 is found to be one of the immediate early genes up-regulated by neural growth factor (NGF) and epidermal growth factor (EGF). Its transcriptional level is also up-regulated by p53, gamma radiation, adriamycin, and UV treatment of cells. BTG seems to be important for the cell cycle progression as BTG2 is preferentially expressed in quiescent cells. Over-expression of BTG2 decreases the growth of NIH3T3 cells and induces neuronal differentiation and prevention apoptosis of PC12 cells. Molecularly, BTG2 expression induces hypophosphorylation of RB and G1 arrest which could be rescued by overexpression of cyclin D1. BTG1 and BTG2 interact with PRMT1 (predominant cellular arginine N-methyltransferase) and increase PRMT1 methyltransferase activity. Box C domain in BTG1 and 2 are responsible for the interaction. Box C domain alone acts as a dominant negative which blocks PRMT1 activity. PRMT1 activity is essential for NGF induced PC12 differentiation, and blocking PRMT1 by Box C domain of BTG1 or 2 induces apoptosis. In addition, BTG2 and HoxB9 interaction enhances the transcription of Hoxb9. Lastly, association of BTG2 and BTG1 with Caf1 is also reported to modulate transcriptional activity of CAF1." }, { "input": "Concept: Cleft Palate Repair (Mouth repair)", "output": "Mouth repair described as the surgical repair of a cleft palate by approximation of the intact tissues surrounding the defect." }, { "input": "Concept: Triplet Repeat (Short Tandem Repeat)", "output": "Biologically Active Substance described as microsatellite repeats consisting of three nucleotides dispersed in the euchromatic arms of chromosomes." }, { "input": "Concept: response to decane (Cell Function)", "output": "Cell Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decane stimulus." }, { "input": "Concept: regulation of ventricular cardiac muscle cell action potential (regulation of cardiac muscle cell contraction)", "output": "regulation of cardiac muscle cell action potential described as any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." }, { "input": "Concept: Positive (Gene Rearrangement Abnormality)", "output": "something described as a molecular abnormality indicating rearrangement of the BRAF gene." }, { "input": "Concept: Right hemithorax cavity (Thoracic cavity structure)", "output": "something described as cavity of hemithorax demarcated from the mediastinum by the medial surface of the right mediastinal pleura." }, { "input": "Concept: Monkey, Rhesus (Cercopithecidae)", "output": "something described as a pale brown macaque, Macaca mulatta." }, { "input": "Concept: Blasts 2 Percent or More of Bone Marrow Nucleated Cells (Blasts 1 Percent or More of Bone Marrow Nucleated Cells)", "output": "something described as a semi-quantitative microscopic finding indicating that at least 2 percent of the nucleated cells in a bone marrow sample are immature mononuclear cells." }, { "input": "Concept: reading skills (Student Characteristics & Academic Environment)", "output": "Ability described as proficiency in reading developed through practice and influenced by ability. Includes word recognition, pronunciation, and comprehension." }, { "input": "Concept: response to butyrate (response to fatty acid)", "output": "response to fatty acid described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butyrate stimulus." }, { "input": "Concept: death receptor activator activity (receptor ligand activity)", "output": "something described as interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor." }, { "input": "Concept: Orthoses, Upper Limb, Wrist (Orthoses, Upper Limb)", "output": "Medical Device described as upper-limb orthoses designed for external modification of the structural and/or functional characteristics of the wrist joint, providing controlled motions and/or immobilization and support. These orthoses are usually classified according to the function of the orthoses (e.g., immobilization, support, therapeutic, functional) and the physical characteristics (e.g., shape, consistency) and/or material used to make the orthosis (metal, plastics or a combination of these). Wrist upper-limb orthoses may consist of soft orthoses (e.g., a combination of cuffs, straps, and flexible mechanisms) that are intended to provide limited support and stabilization or semi-rigid orthoses that can provide a high degree or total immobilization of the wrist joint. Wrist upper-limb orthoses are intended mainly to provide motion control of the wrist movements, for complete immobilization of the wrist joint, and to avoid pain after injuries or trauma. Dedicated wrist orthoses for static and/or dynamic therapy, and for use during normal daily activities (i.e., functional) are also available." }, { "input": "Concept: Clinical Trial Investigator Site Documentation (Intellectual Product)", "output": "something described as subcategory name for the eTMF domain containing documentation related to a specific investigator site." }, { "input": "Concept: 4q26-q27 (Chromosome band)", "output": "something described as a chromosome band present on 4q" }, { "input": "Concept: HLA-SB Antigens (HLA Antigens)", "output": "HLA Antigens described as a group of the D-related HLA antigens (human) found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases." }, { "input": "Concept: Polyurethane foam dressing (Medical Device)", "output": "Medical dressing described as synthetic dressings made of hydrophilic synthetic polymers (typically a polyurethane foam containing small chambers). These dressings are usually made of thick plastic film (i.e., sheets) or porous sponge-like materials that are highly permeable to vapors and oxygen but impermeable to liquids and bacteria. Foam dressings usually absorb wound exudates; they are used mainly in wound management." }, { "input": "Concept: Human immunodeficiency virus test (Diagnosis)", "output": "Procedure to identify antibody described as a laboratory test used to determine the presence of the human immunodeficiency virus." }, { "input": "Concept: chloride ion homeostasis (monovalent inorganic anion homeostasis)", "output": "something described as any process involved in the maintenance of an internal steady state of chloride ions within an organism or cell." }, { "input": "Concept: purchased (Action)", "output": "something described as the action of obtaining something by payment." }, { "input": "Concept: Products, Dairy (Food)", "output": "something described as raw and processed or manufactured milk and milk-derived products. These are usually from cows (bovine) but are also from goats, sheep, reindeer, and water buffalo." }, { "input": "Concept: regulation of neurotransmitter uptake into synaptic vesicle (regulation of synaptic vesicle cycle)", "output": "Cell Function described as any process that modulates the frequency, rate or extent of neurotransmitter loading into synaptic vesicles." }, { "input": "Concept: Duodenum and Ampulla of Vater Neuroendocrine Tumor pM1c TNM Finding v8 (Finding)", "output": "Duodenum and Ampulla of Vater Neuroendocrine Tumor pM1 TNM Finding v8 described as duodenum and ampulla of Vater neuroendocrine tumor with both hepatic and extrahepatic metastases." }, { "input": "Concept: min.ug/ml/(mg/g/d) (Quantitative Concept)", "output": "Quantitative Concept described as minute times microgram per milliliter, divided by milligram per gram per day." }, { "input": "Concept: Set1/COMPASS complex (histone methyltransferase complex)", "output": "something described as a conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." }, { "input": "Concept: support advanced cardiac life (Cardiopulmonary Resuscitation)", "output": "Life Support Care described as the use of sophisticated methods and equipment to treat cardiopulmonary arrest. Advanced Cardiac Life Support (ACLS) includes the use of specialized equipment to maintain the airway, early defibrillation and pharmacological therapy." }, { "input": "Concept: Solanum Alkaloids (Organic Chemical)", "output": "Organic Chemical described as alkaloids, mainly tropanes, elaborated by plants of the family Solanaceae, including Atropa, Hyoscyamus, Mandragora, Nicotiana, Solanum, etc. Some act as cholinergic antagonists; most are very toxic; many are used medicinally." }, { "input": "Concept: Bedding and Linens (Equipment and Supplies, Hospital)", "output": "Equipment and Supplies, Hospital described as articles of cloth, usually cotton or rayon and other synthetic or cotton-blend fabrics, used in households, hospitals, physicians' examining rooms, nursing homes, etc., for sheets, pillow cases, toweling, gowns, drapes, and the like." }, { "input": "Concept: Gait instability (Central Nervous System)", "output": "Finding of walking balance described as a shaky or wobbly manner of walking." }, { "input": "Concept: Ann Arbor Stage II Lymphoma (Lymphoma by Ann Arbor Stage)", "output": "Neoplastic Process described as ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE)." }, { "input": "Concept: Family History of Stomach Cancer Present (Finding)", "output": "Finding described as there is a family history of stomach cancer." }, { "input": "Concept: Atrophic Lichen Planus (Lichen Planus)", "output": "Lichen Planus described as a rare form of lichen planus that is characterized by well-demarcated, white-bluish papules or plaques with central atrophy." }, { "input": "Concept: larval locomotory behaviour (larval behavior)", "output": "something described as locomotory behavior in a larval (immature) organism." }, { "input": "Concept: Intrahepatic Cholangiocarcinomas (Liver and Intrahepatic Biliary Tract Carcinoma)", "output": "Carcinoma described as a carcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree. Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor." }, { "input": "Concept: OPC6-trans-2-enoyl-CoA hydratase activity (Molecular Function)", "output": "hydro-lyase activity described as catalysis of the reaction: OPC6-3-hydroxyacyl-CoA <=> OPC6-trans-2-enoyl-CoA + H2O." }, { "input": "Concept: {CAPLET} (Quantitative Concept)", "output": "Potency Unit described as a dosing measurement based on the caplet unit." }, { "input": "Concept: Technologies, Wireless (Telecommunications)", "output": "Telecommunications described as techniques using energy such as radio frequency, infrared light, laser light, visible light, or acoustic energy to transfer information without the use of wires, over both short and long distances." }, { "input": "Concept: Measured intake of fluid from food in 24 hours (Nutrient Intake)", "output": "something described as the known intake in one day of fluid from food intake." }, { "input": "Concept: Stereotactic Headframes (Medical Device)", "output": "Stereotactic Systems described as devices that are affixed to a patient's skull to allow precise localization of an area within the brain targeted for a neurosurgical or radiosurgical procedure. These units typically consist of a head ring assembly with fixation screws or pins, an arc system for setting target coordinates and localizer frames and adapters for CT, MRI and other imaging systems." }, { "input": "Concept: Differentiated Thyroid Gland Carcinoma by AJCC v7 Stage (Neoplastic Process)", "output": "something described as a term that refers to the staging of differentiated thyroid gland carcinoma, following the rules of the TNM AJCC v7 classification system." }, { "input": "Concept: Interferon Gamma Measurement (Interferon Measurement)", "output": "Interferon Measurement described as the determination of the amount of interferon gamma present in a sample." }, { "input": "Concept: Nasoturbinal concha (Region of surface of viscerocranial mucosa)", "output": "something described as ridge on the lateral internal nasal wall due to the ethmoidal crest of the maxilla" }, { "input": "Concept: Involuntary movement functions, unspecified (Organism Function)", "output": "Movement described as functions of unintentional, non- or semi-purposive involuntary contractions of a muscle or group of muscles." }, { "input": "Concept: TITRIMETRIC, FATTY ACIDS (Indicator, Reagent, or Diagnostic Aid)", "output": "something described as a fatty acids test system is a device intended to measure fatty acids in plasma and serum. Measurements of fatty acids are used in the diagnosis and treatment of various disorders of lipid metabolism." }, { "input": "Concept: T-Cell Large Granular Lymphocyte Leukemia, Common Variant (T-Cell Large Granular Lymphocyte Leukemia)", "output": "Neoplastic Process described as t-cell large granular lymphocyte leukemia defined by the presence of CD3-positive, CD8-positive, and T-cell receptor alpha-beta-positive cytotoxic T-cells." }, { "input": "Concept: Warfare and Armed Conflicts (Human-caused Phenomenon or Process)", "output": "something described as engaging in any type of conflict including war or military conflict against another nation or organized group." }, { "input": "Concept: Cardiac Function Study (Research Activity)", "output": "something described as the study and analysis of the normal or abnormal functioning of the heart using methods such as echocardiography, exercise stress cardiography, 24-hour Holter EKG and magnetic resonance imaging." }, { "input": "Concept: Aqua marina (Pharmacologic Substance)", "output": "Pharmacologic Substance described as sea water." }, { "input": "Concept: ferrum metallicum/iron (Homeopathic remedies letter F)", "output": "Pharmacologic Substance described as homeopathic drug" }, { "input": "Concept: TG(Z) (Enzyme)", "output": "Amino Acid, Peptide, or Protein described as protein-glutamine gamma-glutamyltransferase Z (710 aa, ~80 kDa) is encoded by the human TGM7 gene. This protein is involved in protein cross-linking and conjugation of polyamines to proteins." }, { "input": "Concept: Dual Specificity Protein Phosphatase hVH3 (Amino Acid, Peptide, or Protein)", "output": "something described as dual specificity protein phosphatase 5 (384 aa, ~42 kDa) is encoded by the human DUSP5 gene. This protein is involved in the dephosphorylation of MAP kinase family proteins." }, { "input": "Concept: Enterobacter taylorae Farmer et al. 1985 (Enterobacter)", "output": "Bacterium described as any bacterial organism that can be assigned to the species Enterobacter cancerogenus." }, { "input": "Concept: Aircraft Smoke Exposure (Finding)", "output": "exposure to smoke described as environmental, occupational or consumer-based exposure to airborne gases and particulates produced when an aircraft is in operation." }, { "input": "Concept: Alternating radiolucent and radiodense metaphyseal lines (Finding)", "output": "Finding described as areas of radio-opaque sclerotic bands alternating with those of normal lucency give rise to stripes akin to a zebra." }, { "input": "Concept: Pseudoepiphyses of middle phalanx of middle-finger (Anatomical Abnormality)", "output": "Pseudoepiphyses of the 3rd finger described as a secondary ossification center in the middle phalanx of the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." }, { "input": "Concept: Mycosis fungoides/Sezary syndrome NOS (Lymphoma, T-Cell, Cutaneous)", "output": "Lymphoma, T-Cell, Cutaneous described as mature T and NK neoplasms predominantly affecting the skin and the peripheral blood. Peripheral blood involvement by abnormal T-cells (cerebriform cells) is a late manifestation of mycosis fungoides, whereas it is the presenting finding in Sezary syndrome." }, { "input": "Concept: prostate field specification (developmental process involved in reproduction)", "output": "specification of animal organ identity described as the process that results in the delineation of a specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop." }, { "input": "Concept: Peritoneal laceration (Injury or Poisoning)", "output": "something described as a cut or tear of the peritoneum." }, { "input": "Concept: type II interferon production (cytokine production)", "output": "something described as the appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." }, { "input": "Concept: Metastatic Extraosseous Myxoid Chondrosarcoma (Neoplastic Process)", "output": "Extraskeletal Myxoid Chondrosarcoma described as an extraskeletal myxoid chondrosarcoma which has spread to another anatomic site." }, { "input": "Concept: Mucous Thread Measurement (Chemical procedure)", "output": "something described as the determination of the number of mucous threads present in a sample." }, { "input": "Concept: Complement CH100 (Complement Measurement)", "output": "Laboratory Procedure described as a measurement of the complement required to lyse 100 percent of red blood cells in a biological specimen." }, { "input": "Concept: PODCI141 (Intellectual Product)", "output": "something described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported Version (PODCI Pediatric Parent-Reported Version) If you answered \"no\" to Question 36 above, was your child's activity limited by: Dislike of recreational outdoor activities?" }, { "input": "Concept: Cyclin D1b (Biologically Active Substance)", "output": "CCND1 Gene Product described as g1/S-specific cyclin-D1b is encoded by the human CCND1 gene. This protein may play a role in the promotion of tumor cell invasiveness and anchorage-independent growth." }, { "input": "Concept: MONOBLLE (Laboratory Procedure)", "output": "Blood Cell Count Ratio Measurement described as the determination of the ratio of monoblast cells compared to leukocytes present in a sample. The measurement may be expressed as a ratio or percentage." }, { "input": "Concept: Foetal death after 22 week gestation affecting management of mother (maternal conditions during pregnancy)", "output": "maternal conditions during pregnancy described as fetal death after 22 week gestation affecting management of mother" }, { "input": "Concept: complement binding (Protein Binding)", "output": "Molecular Function described as interacting selectively and non-covalently with any component or product of the complement cascade." }, { "input": "Concept: Pedunculus, Basis (Midbrain structure)", "output": "Peduncle of neuraxis described as a region of the brain encompassing the crus cerebri and the midbrain tegmentum." }, { "input": "Concept: AUMC to Last Nonzero Conc Norm by Dose (Area Under First Moment Curve)", "output": "Quantitative Concept described as the area under the moment curve (AUMC) from the time of dosing to the last measurable concentration divided by the dose." }, { "input": "Concept: Chief Complaint - Onset (ACC-AHA Measure)", "output": "Temporal Concept described as the time period when the chief complaint first occurred." }, { "input": "Concept: Metanephric Tumor (Benign Epithelioma)", "output": "Neoplastic Process described as a neoplasm arising from the distal convoluted tubule and collecting duct areas of the kidney." }, { "input": "Concept: Transmissible Spongiform Encephalopathy Statement (Statement)", "output": "something described as a declaration that proper measures have been taken to ensure that the risk for spreading transmissible spongiform encephalopathy (TSE) through the use of the Investigational Product (IP) has been minimized, which may include being manufactured with materials of a non-animal origin." }, { "input": "Concept: SUPERNATANT, SERUM (Supernatant)", "output": "Body Substance described as the liquid lying above a liquid, solid or semi-solid residue, which is separated by crystallization, precipitation or centrifugation of a serum sample." }, { "input": "Concept: DRRI1-P: Family Know What I Think/Feel (Intellectual Product)", "output": "Intellectual Product described as deployment Risk and Resilience Inventory-2 (DRRI-2) Since returning: family members know what I think and how I feel about things." }, { "input": "Concept: Kurloff Cells (Laboratory Procedure)", "output": "Cell Count described as the determination of the amount of large secretory granule-containing immune cells in a biological specimen taken from members of certain genera of the Caviidae family." }, { "input": "Concept: Product containing levofolinic acid (leucovorin)", "output": "Pteridines described as the active l-isomer of the racemic mixture of the 5-formyl derivative of tetrahydrofolic acid. Metabolically active, l-leucovorin, also known levoleucovorin, does not require bioactivation by dihydrofolate reductase, an enzyme inhibited by folic acid antagonists. This agent may enhance the effects of fluoropyrimidines by stabilizing their binding to the enzyme thymidylate synthase." }, { "input": "Concept: Mode of Inheritance (Genetic Function)", "output": "All described as the manner in which a particular genetic trait or disorder is passed from one generation to the next." }, { "input": "Concept: positive regulation of Wnt protein secretion (positive regulation of protein secretion)", "output": "positive regulation of signaling described as any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell." }, { "input": "Concept: Product containing nandrolone (OTHER OPHTHALMOLOGICALS IN ATC)", "output": "Estranes described as a synthetic, anabolic steroid analog of testosterone. Similar to testosterone, nortestosterone (19-Nortestosterone) binds to and activates specific nuclear receptors. This agent may be used for testosterone replacement therapy in hypogonadal men, in HIV-wasting syndrome, and in other conditions in order to increase nitrogen retention and fat-free muscle mass." }, { "input": "Concept: Precursor (Conceptual Entity)", "output": "something described as a substance from which another substance is formed." }, { "input": "Concept: Eccentric muscle contraction (Muscle Contraction)", "output": "Organ or Tissue Function described as lengthening of muscle during contraction due to an external force." }, { "input": "Concept: Phenocopy (Miscellaneous Molecular Biology Terms)", "output": "something described as an environmentally produced phenotype simulating the effect of a particular genotype." }, { "input": "Concept: (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (intramolecular oxidoreductase activity)", "output": "cyclase activity described as catalysis of the reaction: (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate." }, { "input": "Concept: RP11-316M1.10 (MLLT11 gene)", "output": "MLLT11 gene described as human MLLT11 wild-type allele is located in the vicinity of 1q21 and is approximately 11 kb in length. This allele, which encodes protein AF1q, plays a role in both depolarization of and release of cytochrome c by the mitochondrion. The gene is involved in a translocation t(1;11)(q21;q23) with the MLL gene that is associated with acute leukemia." }, { "input": "Concept: bFGF (Amino Acid, Peptide, or Protein)", "output": "Amino Acid, Peptide, or Protein described as a recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 2 (FGF-2). Reflecting its endogenous role, therapeutic FGF-2 exhibits a wide spectrum of biological activities, including the promotion of growth and differentiation in target cells, the regulation of hormone secretion, and the promotion of angiogenesis. This agent's mitogenic effects on fibroblasts and endothelial cells indicates a potential role in therapeutic angiogenesis and wound healing. In addition, therapeutic FGF-2 may stimulate neurogenesis and protect neurons against degeneration; FGF-2 supplementation via gene transfer may reduce neuronal degeneration in experimental animal models." }, { "input": "Concept: Use of supportive positioning (Care plan)", "output": "Health Care Activity described as when positioning patient in bed, involves the use of any of several support devices designed to help ensure proper body alignment and to make the patient more comfortable. Some of these are pillows, foot boards, trochanter rolls and hand rolls." }, { "input": "Concept: Failure to Power Up (Power Problem)", "output": "something described as problem associated with the inability of the device to turn on related to energy delivered to a medical device." }, { "input": "Concept: venetoclax (Sulfonamides)", "output": "Molecular Target Inhibitors described as an orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. Venetoclax mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells. Bcl-2 protein is overexpressed in some cancers and plays an important role in the regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival. Compared to the Bcl-2 inhibitor navitoclax, this agent does not inhibit bcl-XL and does not cause bcl-XL-mediated thrombocytopenia. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C103147\" active clinical trials using this agent." }, { "input": "Concept: Sharps container (Needle device)", "output": "Cannula device described as a hypodermic single lumen needle is a device intended to inject fluids into, or withdraw fluids from, parts of the body below the surface of the skin. The device consists of a metal tube that is sharpened at one end and at the other end joined to a female connector (hub) designed to mate with a male connector (nozzle) of a piston syringe or an intravascular administration set." }, { "input": "Concept: ABBV744 (BET Inhibitor)", "output": "Pharmacologic Substance described as an orally bioavailable inhibitor of the Bromodomain and Extra-Terminal (BET) family of proteins, with potential antineoplastic activity. Upon oral administration, the BET inhibitor ABBV-744 preferentially binds to the second bromodomain (BD2) of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histones. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of proliferation in BET-overexpressing tumor cells. BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that contain two homologous bromodomains, the BD1 and BD2 domains. They play an important role during development and cellular growth. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C148415\" active clinical trials using this agent." }, { "input": "Concept: Non-caseating epithelioid cell granulomatosis (Granulomatosis)", "output": "Finding described as the presence of multiple epithelioid cell granulomas consist of highly differentiated mononuclear phagocytes (epithelioid cells and giant cells) and lymphocytes, not exhibiting caseation (a form of necrosis in which the tissue changes into a dry, amorphous mass said to resemble cheese)." }, { "input": "Concept: RED-CELL INDICES DEVICE (Medical Device)", "output": "something described as a red cell indices device, usually part of a larger system, calculates or directly measures the erythrocyte mean corpuscular volume (MCV), the mean corpuscular hemoglobin (MCH), and the mean corpuscular hemoglobin concentration (MCHC). The red cell indices are used for the differential diagnosis of anemias." }, { "input": "Concept: negative regulation of mononuclear cell proliferation (Cell Function)", "output": "Cell Function described as any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation." }, { "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, GLUD1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", "output": "Medical Device described as molecular assay reagents intended to identify mutations in the glutamate dehydrogenase 1 (GLUD1) gene, located at chromosome 10q23.3, which regulates the elevation of glutamate dehydrogenase activity and may induce glutamine-stimulated insulin secretion. Mutations at this locus have been identified in patients with early-onset infantile hyperinsulinism-hyperammonemia syndrome." }, { "input": "Concept: short-branched-chain-acyl-CoA dehydrogenase activity (Molecular Function)", "output": "something described as catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a short branched chain fatty acid residue." }, { "input": "Concept: Daily tobacco smoker (Tobacco smoking consumption - finding)", "output": "Current Smoker described as every Day Smoker SNOMEDCT Value Set" }, { "input": "Concept: N-terminal myristoylation domain binding (Molecular Function)", "output": "Molecular Function described as interacting selectively and non-covalently with the N-terminus of a protein that has the potential to be, or has been, modified by N-terminal myristoylation. Binding affinity is typically altered by myristoylation; for example, N-terminal myristoylation of HIV Nef increases its affinity for calmodulin." }, { "input": "Concept: TT (Intellectual Product)", "output": "Domain described as a subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to trial stages." }, { "input": "Concept: Log10 Colony Forming Units per Gram (Unit of Arbitrary Substance Concentration)", "output": "Unit of Arbitrary Substance Concentration described as a logarithmic-scale (base 10) unit for measuring colony forming units per unit of mass equal to one gram." }, { "input": "Concept: Identity Formation (Mental Process)", "output": "Thesaurus of Psychological Index Terms described as the process of developing one's identity based on early influences and experiences." }, { "input": "Concept: Animal Behavior (Behavior)", "output": "Behavior described as study of animal behavior especially in relation to ecology, evolution, neuroanatomy, neurophysiology, and genetics. Used for the discipline or the ethological processes themselves. Use a more specific term if possible." }, { "input": "Concept: Blasts Over 60 Percent of Bone Marrow Nucleated Cells (Finding)", "output": "Finding described as a semi-quantitative microscopic finding indicating that more than 60 percent of the nucleated cells in a bone marrow sample are immature mononuclear cells." }, { "input": "Concept: Bladder adenocarcinoma stage I (Bladder Neoplasm)", "output": "something described as stage I includes: T1, N0, M0. T1: Tumor invades subepithelial connective tissue. N0: No regional lymph node metastasis. M0: No distant metastasis." }, { "input": "Concept: WHODAS 2.0 36-item Version Proxy-administered - Doing Important Work or School Tasks (WHODAS 2.0 36-item Version Proxy-administered Questionnaire Question)", "output": "WHODAS 2.0 36-item Version Proxy-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Proxy - In the past 30 days, how much difficulty did your relative have in: Doing his or her most important work/school tasks well?" }, { "input": "Concept: deoxyuridine metabolism (pyrimidine deoxyribonucleoside metabolic process)", "output": "something described as the chemical reactions and pathways involving deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." }, { "input": "Concept: Clinical Trials, Veterinary as Topic (Intellectual Product)", "output": "Clinical Studies as Topic described as works about clinical studies in which animal participants are assigned to receive one or more interventions so that researchers can evaluate the interventions on biomedical or health-related outcomes. The assignments are determined by the study protocol. Animal participants may receive diagnostic, therapeutic, or other types of interventions." }, { "input": "Concept: Neuropathies, Small Fiber (Peripheral neuropathies NEC)", "output": "Disease or Syndrome described as neuropathy caused by damage to the small myelinated (A-delta) fibers or unmyelinated C fibers in the peripheral nerves. It manifests with burning pain, shooting pain, allodynia, and hyperesthesia." }, { "input": "Concept: Stage IVC Pharyngeal Carcinoma (Stage IV Pharynx Carcinoma)", "output": "something described as stage IVC carcinoma of the pharynx according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions." }, { "input": "Concept: Breast implants (Implants)", "output": "something described as implantable devices designed for breast reconstruction and/or augmentation. These implants typically consist of an outer shell (e.g., silicone elastomer) that may include single or double (i.e., one shell inside the outer shell) lumen, a liquid or gel filler, and a patch to seal the shell once filled. The shell may be prefilled or filled during the surgery; some implants allow filler volume adjustment after implantation. Breast implants are available in a variety of surfaces, shapes, volumes, and shell thicknesses; they are usually filled with liquid (typically saline) and gel (typically silicone gel)." }, { "input": "Concept: hemolysis (pathologic cytolysis)", "output": "Blood Physiological Phenomena described as destruction of red blood cells, with the liberation of hemoglobin into the plasma." }, { "input": "Concept: Clacium-binding troponin subunit (Proteins)", "output": "Biologically Active Substance described as a TROPONIN complex subunit that binds calcium and help regulate calcium-dependent muscle contraction. There are two troponin C subtypes: troponin C1 and C2. Troponin C1 is skeletal and cardiac type whereas troponin C2 is skeletal type. Troponin C1 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin C1 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY." }, { "input": "Concept: Lactobacillus gasseri (Bacterium)", "output": "something described as any bacterial organism that can be assigned to the species Lactobacillus gasseri." }, { "input": "Concept: MMS204B (MMSE-2 Standard Version Functional Test Question)", "output": "Intellectual Product described as mini-Mental State Examination 2 Standard Version - What were those three words I asked you to remember: Word 2?" }, { "input": "Concept: Hypoplastic areola (Anatomical Abnormality)", "output": "Abnormal areolar morphology described as underdevelopment of the areola, the circular area of pigmented skin surrounding the nipple." }, { "input": "Concept: beta-2 adrenergic receptor binding (Molecular Function)", "output": "adrenergic receptor binding described as interacting selectively and non-covalently with a beta-2 adrenergic receptor." }, { "input": "Concept: Pyridoxal Kinase (Enzyme)", "output": "Enzyme described as an enzyme that catalyzes reversibly the phosphorylation of pyridoxal in the presence of ATP with the formation of pyridoxal 5-phosphate and ADP. Pyridoxine, pyridoxamine and various derivatives can also act as acceptors. EC 2.7.1.35." }, { "input": "Concept: Etiocholanolone (17-Ketosteroids)", "output": "11-deoxy-17-ketosteroid described as a 17-ketosteroid which excreted in the urine as a metabolite of steroid hormones. The most common form of etiocholanolone present in the urine is the sulfate salt. This agent, also known as 5-isoandrosterone, may be used to evaluate adrenal cortex function, bone marrow performance and, in neoplastic disease, for immunostimulation." }, { "input": "Concept: Encephalomalacia (Brain Diseases)", "output": "Abnormal cerebral morphology described as localized atrophy of the brain parenchyma due to aging, hemorrhage, infarct, or inflammation." }, { "input": "Concept: Infant milestone: 1 month (Finding)", "output": "Finding described as milestones of physical, cognitive, and psychosocial progression by 1 month of age" }, { "input": "Concept: Size of Persistent and Solid Component of a Subsolid Pulmonary Nodule (Quantitative Concept)", "output": "size described as the size of the solid component of a solitary part-solid nodules, as observed through CT imaging." }, { "input": "Concept: Stage IIB Small Intestinal Adenocarcinoma (Neoplastic Process)", "output": "Neoplastic Process described as stage IIB includes: T4, N0, M0. T4: Tumor perforating the visceral peritoneum or directly invading other organs or structures (e.g., other loops of small intestine, mesentery of adjacent loops of bowel, and abdominal wall by way of serosa; for duodenum only, invasion of pancreas or bile duct). N0: No regional lymph node metastasis. M0: No distant metastasis." }, { "input": "Concept: mitochondrial proton-transporting ATP synthase, central stalk (inner mitochondrial membrane protein complex)", "output": "proton-transporting ATP synthase, central stalk described as one of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis." }, { "input": "Concept: DRRI1-I: Could Count on Family Advice (Intellectual Product)", "output": "Intellectual Product described as deployment Risk and Resilience Inventory-2 (DRRI-2) During deployment: I could count on my family members or friends at home for good advice." }, { "input": "Concept: Grade 2 Anorectal Infection, CTCAE (Anorectal Infection, CTCAE)", "output": "something described as oral intervention indicated" }, { "input": "Concept: Fatty Acid 23:1 (Fatty Acids, Monounsaturated)", "output": "something described as a monounsaturated very long-chain fatty acid with a 23-carbon backbone and a single double bond. The 23:1 class of fatty acids is rarely found in nature." }, { "input": "Concept: Fluticason (Androstadienes)", "output": "Corticosteroid [EPC] described as a STEROID with GLUCOCORTICOID RECEPTOR activity that is used to manage the symptoms of ASTHMA; ALLERGIC RHINITIS, and ATOPIC DERMATITIS." }, { "input": "Concept: response to anoxia (Organism Function)", "output": "something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." }, { "input": "Concept: limonene synthesis (olefin biosynthetic process)", "output": "organic cyclic compound biosynthetic process described as the chemical reactions and pathways resulting in the formation of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." }, { "input": "Concept: Sclerosing Mucoepidermoid Thyroid Carcinoma with Eosinophilia (Neoplastic Process)", "output": "something described as a rare type of mucoepidermoid carcinoma of the thyroid gland, usually associated with chronic lymphocytic thyroiditis. It exhibits a unique morphologic appearance consisting of a squamoid, nested growth pattern, dense fibrosis, and mucinous differentiation. The histogenesis of this unusual carcinoma has been debated, and it is unclear if it arises from remnants of the ultimobranchial body or from the follicular epithelial cells." }, { "input": "Concept: Appliance, Extraoral Traction (Medical Device)", "output": "Medical Device described as extraoral devices for applying force to the dentition in order to avoid some of the problems in anchorage control met with in intermaxillary traction and to apply force in directions not otherwise possible." }, { "input": "Concept: Breast Cancer Risk Factor (Qualitative Concept)", "output": "Qualitative Concept described as any factor, such as age, ethnicity, genetic factor, family history, over-exposure to estrogen, or environmental factors, that increases a person's chance of developing breast cancer." }, { "input": "Concept: Testing, 2019-nCoV (Laboratory Procedure)", "output": "Clinical Laboratory Techniques described as diagnosis of COVID-19 by assaying bodily fluids or tissues for the presence of COVID-19 antibodies, SARS-COV-2 antigens or the VIRAL RNA of SARS-COV-2." }, { "input": "Concept: Papillary Adenoma of the Kidney (Benign tumor of renal parenchyma)", "output": "Renal Adenoma described as a low grade, unencapsulated neoplasm with papillary, tubular, or tubulopapillary architecture, less than 15 mm in size." }, { "input": "Concept: Atrio-digital syndrome (Syndrome)", "output": "Multiple malformation syndrome with limb defect as major feature described as holt-Oram syndrome is the most common form of heart-hand syndrome with characteristics of skeletal abnormalities of the upper limbs and mild-to-severe congenital cardiac defects. The clinical picture of covers a wide spectrum of upper extremity defects, always including the radial ray, and cardiac defects. Caused by a mutation in the TBX5 gene located on the long arm of chromosome 12 (12q24.1)." }, { "input": "Concept: Mofarontene (Organic Chemical)", "output": "Retinoids described as an arotinoic acid derivative with a morpholine structure in the polar end group with differentiation inducing and antineoplastic activity. Like other retinoic acid agents, mofarotene binds to and activates retinoic acid receptors (RARs), thereby altering the expression of certain genes leading to cell differentiation and decreased cell proliferation in susceptible cells. In addition, this agent is able to inhibit melanoma cell motility." }, { "input": "Concept: singleCollimationWidth (Width)", "output": "Width described as the width of a single row of acquired data." }, { "input": "Concept: hypervascular (Qualitative Concept)", "output": "Qualitative Concept described as having a large number of blood vessels." }, { "input": "Concept: protein heterotrimer biosynthetic process (Molecular Function)", "output": "something described as the formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical." }, { "input": "Concept: DAHL-S (Mammal)", "output": "Common Rattus Norvegicus Strains described as derived by Rapp from a colony of Sprague-Dawley rats that were initially derived by LK Dahl at Brookhaven National Laboratories. The SS rat strain has been selected for its acute salt sensitivity, leading to the development of hypertension, diabetes, nephropathy, cardiac hypertrophy, heart failure, cholesterolemia, hyperinsulinemia, hypertriglyceridemia. This rat strain is used as an animal model in the study of human hypertension." }, { "input": "Concept: History of Trauma in Chief Complaint (Finding)", "output": "ACC-AHA Measure described as a traumatic event preceded the chief complaint." }, { "input": "Concept: PODCI Pediatric Parent-Reported Version - Bicycle or Tricycle (PODCI Pediatric Parent-Reported Version Questionnaire Question)", "output": "PODCI Pediatric Parent-Reported Version Questionnaire Question described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported Version (PODCI Pediatric Parent-Reported Version) During the last week, has it been easy or hard for your child to: Bicycle or tricycle?" }, { "input": "Concept: Squamous Cell Carcinoma of the Penis, Basaloid Type (Penis carcinoma)", "output": "Human Papillomavirus-Related Squamous Cell Carcinoma of the Penis described as an aggressive, human papillomavirus-related squamous cell carcinoma that arises from the penis. It is characterized by the presence of nests of small malignant cells. The malignant cells tend to invade deeply into the adjacent tissues. Comedo-type necrosis is often present." }, { "input": "Concept: CHSF206 (CHART-SF Paper Version Questionnaire Question)", "output": "Intellectual Product described as craig Handicap Assessment and Reporting Technique - Short Form Paper Version (CHART-SF Paper Version) In the last year, how many nights have you spent away from your home (excluding hospitalizations)?" }, { "input": "Concept: Cyclophosphamide/Fludarabine/Alemtuzumab/Rituximab Regimen (Therapeutic or Preventive Procedure)", "output": "Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of cyclophosphamide, fludarabine, alemtuzumab, and rituximab that may be used in the treatment of chronic lymphocytic leukemia (CLL)." }, { "input": "Concept: Orthoses, Upper Limb, Finger, Inter-Phalangeal Joint, Therapeutic (Orthoses, Upper Limb, Finger, Inter-Phalangeal Joint)", "output": "something described as inter-phalangeal (IP) joint orthoses designed for external modification of the structural and/or functional characteristics of the fingers. These devices control and restrict movement of the IP joints during therapeutic treatments. These orthoses may consist of a variety of devices, typically including a semi-rigid, lightweight, plastic structure with aluminum stays and closure straps or sleeves that permit controlled flexion and/or extension of both (proximal and distal) IP joints. IP joint orthoses (e.g., splints) are used to prevent further development of finger deformities and/or for rehabilitation usually after corrective surgery. Dedicated orthoses intended to keep the proximal and distal IP joints in controlled flexion and extension, respectively (e.g., swan-neck splints), are also available." }, { "input": "Concept: Patient Belongings Bags (Manufactured Object)", "output": "Manufactured Object described as bags designed for the temporary storage, protection and/or transportation of a patient's personal belongings (e.g., clothing, wallets, jewelry, etc.). These bags are typically made of plastic and may have drawstrings or handles. Some bags have a barcode to facilitate tracking and/or a security/tamper-resistant mechanism." }, { "input": "Concept: Linear Parameter Identification (Idea or Concept)", "output": "something described as a consequence of a mathematical model in which all parameters appear as separate data coefficients to the first power in the equations used to evaluate these from fitting the model to data." }, { "input": "Concept: down regulation of execution phase of apoptosis (regulation of execution phase of apoptosis)", "output": "regulation of execution phase of apoptosis described as any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis." }, { "input": "Concept: Nerves, Twelfth Cranial (craniospinal nerves)", "output": "craniospinal nerves described as the twelfth cranial nerve. It arises from the hypoglossal nucleus and leads to the tongue." }, { "input": "Concept: gluten (Proteins)", "output": "Food described as prolamins in the endosperm of SEEDS from the Triticeae tribe which includes species of WHEAT; BARLEY; and RYE." }, { "input": "Concept: Epididymis (Epididymis disorders)", "output": "Neoplastic Process described as a primary or metastatic malignant neoplasm that affects the epididymis. Representative examples include primary epididymal adenocarcinoma and metastatic carcinoma to the epididymis arising from another anatomic site." }, { "input": "Concept: PANSS113 (Intellectual Product)", "output": "Intellectual Product described as positive and Negative Syndrome Scale (PANSS) Temperature - Lack of spontaneity and flow of conversation." }, { "input": "Concept: urinary diversions (Procedure on organ)", "output": "Creation of shunt described as a surgical procedure to make a new way for urine to leave the body. It may involve redirecting urine into the colon, using catheters to drain the bladder, or making an opening in the abdomen and collecting urine in a bag outside the body." }, { "input": "Concept: ankylurethria (Ureter)", "output": "Urethral Diseases described as abnormal narrowing of the urethra." }, { "input": "Concept: contractile vacuole tethering involved in discharge (vesicle targeting)", "output": "vesicle targeting described as the initial, indirect interaction between a contractile vacuole membrane and a site of discharge in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." }, { "input": "Concept: 4-alpha-methyl-delta7-sterol oxidation (lipid oxidation)", "output": "Molecular Function described as a lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4-alpha-methyl-delta7-sterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy,delta7-sterol + 3 NADP+ + 3 H2O." }, { "input": "Concept: LN (Cell Function)", "output": "Nucleophagy described as a type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM." }, { "input": "Concept: Experimental Factor Value With Attribute Value (Intellectual Product)", "output": "Intellectual Product described as the value for this use of the factor. EXAMPLE(S): wild_type (for genotype), 24 hours (for time between doses), Aspirin (for compound), Low Dose (dose), 1C (for temperature) OTHER NAME(S): NOTE(S):" }, { "input": "Concept: Miller-Dieker syndrome (disorder) [Ambiguous] (Classical Lissencephaly)", "output": "Multiple malformation syndrome with unusual brain and/or neuromuscular findings described as a developmental defect of the brain caused by incomplete neuronal migration and characterized by smoothness of the surface of the brain (lissencephaly) occurring in association with absence of the sulci and gyri (agyria) and thickening of the cerebral cortex with four rather than six layers (pachygyria), microcephaly, characteristic facial appearance, retarded growth and mental development, neurological complications, and multiple abnormalities of the brain, kidneys, heart, gastrointestinal tract, and other organs. Lissencephaly, once considered as synonymous with Walker-Warburg syndrome and Norman-Roberts syndrome, is now recognized as a component of several other syndromes. Type I (the classical form) is a component of Miller-Dieker and Norman-Roberts syndromes, also occurring as a separate entity; Type II the Walker-Warburg and muscle-eye-brain syndrome, also occurring in the Neu-Laxova syndrome." }, { "input": "Concept: Benzenamine, 2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)- (Hazardous or Poisonous Substance)", "output": "something described as a microtubule-disrupting pre-emergence herbicide." }, { "input": "Concept: intracellular sterol transport (sterol transport)", "output": "sterol transport described as the directed movement of sterols within cells." }, { "input": "Concept: Products or substances for personal consumption (Entity)", "output": "CHAPTER 1 PRODUCTS AND TECHNOLOGY described as any natural or human-made object or substance gathered, processed or manufactured for ingestion." }, { "input": "Concept: Steroid Hydroxylases (Cytochrome P450)", "output": "Amino Acid, Peptide, or Protein described as cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthesis and metabolism." }, { "input": "Concept: membrane depolarization (Cell Function)", "output": "regulation of membrane potential described as the process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential." }, { "input": "Concept: Syringes, Plunger, Tuberculin/Allergy, Protective, Luer Lock (Syringes, Plunger, Tuberculin/Allergy, Protective)", "output": "Syringes, Plunger, Tuberculin/Allergy, Protective described as tuberculin/allergy syringes with a needle preattached to their Luer-lock tip that are designed to provide needlestick protection (safety). These syringes include some mechanism (manually positioned or activated) intended either to shield, blunt, or recess the needle after use or, by some other means, to lessen the possibility of contact of the healthcare provider with a sharp needle. Luer-lock tapers include an internally threaded skirt or other structure around the taper, adding additional strength to the connection with a female Luer taper." }, { "input": "Concept: intermediate reticular nucleus development (anatomical structure development)", "output": "Organ or Tissue Function described as the process whose specific outcome is the progression of the intermediate reticular formation over time, from its formation to the mature structure." }, { "input": "Concept: amidinoaspartase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines)", "output": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines described as catalysis of the reaction: N-amidino-L-aspartate + H(2)O = L-aspartate + urea." }, { "input": "Concept: Delayed ossification of vertebral epiphysis (Abnormally ossified vertebrae)", "output": "Anatomical Abnormality described as a delay in the process of formation and maturation of the epiphysis of one or more vertebrae." }, { "input": "Concept: Gastric Neuroendocrine Tumor pTX TNM Finding v7 (Finding)", "output": "Finding described as gastric neuroendocrine tumor in which the primary tumor cannot be assessed." }, { "input": "Concept: Eukaryotic Initiation Factor 4A-II, human (Peptide Initiation Factors)", "output": "Peptide Initiation Factors described as eukaryotic initiation factor 4A-II (407 aa, ~46 kDa) is encoded by the human EIF4A2 gene. This protein is involved in the mediation of both ATP hydrolysis and translation of mRNA." }, { "input": "Concept: APO2L/TRAIL (Recombinant Tumor Necrosis Factor Family Protein)", "output": "Pharmacologic Substance described as a recombinant human soluble protein corresponding to amino acids 114-281 of the Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (RhApo2L/TRAIL) with potential antineoplastic activity. Dulanermin binds to and activates TRAIL receptors 1 and 2 (TRAIL-R1/R2), which may activate caspases and induce p53-independent apoptosis in TRAIL-R1/R2-expressing tumor cells. The pro-apoptotic cell surface receptors TRAIL-R1 and -R2, also known as DR4 (death receptor 4) and DR5 (death receptor 5), are members of the TNF receptor family and are overexpressed by a variety of cancer cell types." }, { "input": "Concept: Mitral valve structure (Body part)", "output": "Body part described as a dual-flap valve of the heart that regulates the flow of blood between the left atrium and the left ventricle of the heart." }, { "input": "Concept: plasmacytoid dendritic cell cytokine production (dendritic cell cytokine production)", "output": "dendritic cell cytokine production described as any process that contributes to cytokine production by a plasmacytoid dendritic cell." }, { "input": "Concept: cardiac muscle cell apoptotic process (striated muscle cell apoptotic process)", "output": "something described as a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." }, { "input": "Concept: IgH locus (Gene or Genome)", "output": "Gene type described as this region represents the germline organization of the immunoglobulin heavy chain locus. The locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes." }, { "input": "Concept: cell differentiation in spinal cord (Cell Differentiation process)", "output": "something described as the process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." }, { "input": "Concept: v-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 Mutation Analysis (Genetic Variation Analysis)", "output": "something described as a procedure used to detect and identify mutations in the ERBB2 gene." }, { "input": "Concept: Oncocytic Breast Carcinoma (Adenocarcinoma of breast)", "output": "something described as a rare breast adenocarcinoma characterized by the presence of neoplastic oncocytic cells. The oncocytic cells comprise more than 70 percent of the malignant cellular population." }, { "input": "Concept: Hes-Related Family bHLH Transcription Factor With YRPW Motif-Like wt Allele (HEYL gene)", "output": "something described as human HEYL wild-type allele is located in the vicinity of 1p34.3 and is approximately 17 kb in length. This allele, which encodes hairy/enhancer-of-split related with YRPW motif-like protein, is involved in the modulation of both cardiac development and transcriptional regulation." }, { "input": "Concept: Fungal oesophagitis (Disease or Syndrome)", "output": "Disease or Syndrome described as infection of the esophagus caused by fungi, most often candida albicans and candida tropicalis. It usually affects patients with immunodeficiency disorders or diabetes mellitus. Symptoms include dysphagia and pain on swallowing." }, { "input": "Concept: 16p12 (Chromosome band)", "output": "Cell Component described as a chromosome band present on 16p" }, { "input": "Concept: Difficulty in sleep maintenance (Sleeplessness)", "output": "Sleep described as difficulty maintaining sleep." }, { "input": "Concept: C-SSRS Pediatric/Cognitively Impaired Lifetime/Recent - Actual Suicide Attempt (C-SSRS Pediatric Cognitively Impaired Lifetime Recent Questionnaire Question)", "output": "Intellectual Product described as columbia-Suicide Severity Rating Scale Pediatric/Cognitively Impaired Lifetime/Recent - Did you ever do anything to try to kill yourself or make yourself not alive anymore? What did you do? Did you ever hurt yourself on purpose? Why did you do that? (Past 3 Months)." }, { "input": "Concept: Spectrum, Action (Spectrophotometry)", "output": "Spectrophotometry described as a technique used to measure the rate of physiological activity plotted against wavelength of light. An action spectrum depicts the most effective wavelength of light (also known as spectral sensitivity) that is required for each specific process." }, { "input": "Concept: MIP1aR (Chemokine Receptor Gene)", "output": "Gene or Genome described as this gene is involved in immune cell mobilization to promote pro-inflammatory responses; further, the gene plays a role in chemotaxis." }, { "input": "Concept: CSS0807A (Intellectual Product)", "output": "something described as columbia-Suicide Severity Rating Scale Children's Since Last Visit - Frequency, write response." }, { "input": "Concept: nk cells (T-Lymphocyte)", "output": "Killer Cells described as white blood cells that kill tumor- and virus-infected cells as part of the body's immune system." }, { "input": "Concept: Free ribosome (Ribosomes)", "output": "Ribosomes described as a ribosome that is not associated with the membrane of the rough endoplasmic reticulum." }, { "input": "Concept: Prader-Willi syndrome AND diabetes (Disease or Syndrome)", "output": "Multiple malformation syndrome with unusual brain and/or neuromuscular findings described as an association of DIABETES MELLITUS with Prader-Willi Syndrome." }, { "input": "Concept: Elevated urinary norepinephrine (Elevated urinary catecholamines)", "output": "Elevated urinary catecholamines described as an increased concentration of noradrenaline in the urine." }, { "input": "Concept: 5 alpha Androstan 3 alpha ol 17 one (Androstanols)", "output": "Androgens described as a metabolite of TESTOSTERONE or ANDROSTENEDIONE with a 3-alpha-hydroxyl group and without the double bond. The 3-beta hydroxyl isomer is epiandrosterone." }, { "input": "Concept: 2: 215499872-215418783 (Chromosome 2 Physical Location)", "output": "Spatial Concept described as physical location of BARD1_Gene" }, { "input": "Concept: Imbruvica/Rituxan (Regimen Used to Treat Non-Hodgkin Lymphoma)", "output": "Regimen Used to Treat Non-Hodgkin Lymphoma described as a regimen consisting of ibrutinib and rituximab that may be used in the treatment of primary or previously treated Waldenstr\u00f6m macroglobulinemia and certain non-Hodgkin lymphomas (NHL)." }, { "input": "Concept: Was Tumor Progression Present After Initial Treatment (Intellectual Product)", "output": "CPTAC Questions described as a question about whether the tumor progression was present after the initial treatment." }, { "input": "Concept: Retinoblastoma pT3d TNM Finding v8 (Finding)", "output": "Finding described as full-thickness invasion into the outer third of the sclera and/or invasion into or around emissary channels." }, { "input": "Concept: Powder and solvent for emulsion for injection (Biomedical or Dental Material)", "output": "something described as sterile powder and sterile solvent intended for the preparation of an emulsion for injection by mixing the powder and the solvent." }, { "input": "Concept: IL-23 biosynthetic process (cytokine biosynthesis)", "output": "Molecular Function described as the chemical reactions and pathways resulting in the formation of interleukin-23." }, { "input": "Concept: Transporter, Membrane (Amino Acid, Peptide, or Protein)", "output": "Biologically Active Substance described as diverse family of membrane proteins which catalyze the transfer of small, usually lipophobic solutes across the membrane; may mediate active (ATP-driven), co- (countergradient-driven), or passive transport." }, { "input": "Concept: Disease, White Heifer (Cattle Diseases)", "output": "Disease or Syndrome described as a congenital reproductive abnormality in white female offspring (heifers) in certain breeds of CATTLE, such as Belgian Blue and Shorthorn. The white color is inherited as a recessive trait which is associated with defects in the female reproductive tract (Muellerian system). These heifers are usually sterile." }, { "input": "Concept: viral genome replication (Cell Function)", "output": "viral process described as any process involved directly in viral genome replication, including viral nucleotide metabolism." }, { "input": "Concept: Cathepsin U (Amino Acid, Peptide, or Protein)", "output": "Amino Acid, Peptide, or Protein described as cathepsin L2 (334 aa, ~37 kDa) is encoded by the human CTSV gene. This protein plays a role in proteolysis." }, { "input": "Concept: 1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one (Otic preparation)", "output": "Pyrazolones described as an analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver." }, { "input": "Concept: MYOPHOSPHORYLASE DEFICIENCY (Disease or Syndrome)", "output": "Glycogen storage disease, muscular form described as glycogenosis due to muscle phosphorylase deficiency. Characterized by painful cramps following sustained exercise." }, { "input": "Concept: Adult Day Care (Manufactured Object)", "output": "HealthcareProviderTaxonomyHIPAA - CodeSystem described as home- or center-based care of physically or mentally disabled adults during daytime hours, providing personal, social, and homemaker services." }, { "input": "Concept: Senile gait (Finding)", "output": "something described as cautious gait refers to an excessive degree of age-related changes in walking and fear of falling. The walking difficulties seem out of proportion when considering the patient's actual sensory or motor deficits. The gait appears slow, with a wider base than normal, reduced arm swing bilaterally and a slightly stooped posture. This type of gait change often occurs after the first time a patient has fallen. []" }, { "input": "Concept: glutamine degradation (Molecular Function)", "output": "glutamine family amino acid catabolic process described as the chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid." }, { "input": "Concept: GCS NINDS Version - Confounder: Unknown (Intellectual Product)", "output": "GCS NINDS Version Clinical Classification Question described as glasgow Coma Scale - GCS Confounder Type: unknown." }, { "input": "Concept: Anomaly of septum of nose (Anatomical Abnormality)", "output": "Congenital anomaly of nose described as an abnormality of the nasal septum." }, { "input": "Concept: PKM Measurement (Pyruvate kinase measurement)", "output": "Laboratory Procedure described as the determination of the amount of pyruvate kinase muscle isozyme present in a sample." }, { "input": "Concept: Acanthaceae Juss., 1789 (Lamiales)", "output": "Angiosperm described as a plant family of the order Lamiales. It is characterized by simple leaves in opposite pairs, cystoliths (enlarged cells containing crystals of calcium carbonate), and bilaterally symmetrical and bisexual flowers that are usually crowded together. The common name for Ruellia of wild petunia is easily confused with PETUNIA." }, { "input": "Concept: Product containing urea 13-C (Diagnostic agents)", "output": "OTHER DIAGNOSTIC AGENTS in ATC described as a radiolabelled urea molecule used to diagnose stomach ulcers caused by Heliobacter pylori. In the presence of H. pylori, urea C-13 is metabolized by urease to produce ammonia and radioactive carbon dioxide at the interface between the gastric epithelium and lumen. The radioactive carbon dioxide is absorbed in the blood and is detected when exhaled in the breath." }, { "input": "Concept: MSCDUR (Temporal Concept)", "output": "something described as collected duration of a microbiology susceptibility event or finding." }, { "input": "Concept: protein tyrosine phosphatase complex location (phosphatase complex)", "output": "something described as a protein complex which is capable of protein tyrosine phosphatase activity." }, { "input": "Concept: Circumflex (Spatial Concept)", "output": "Spatial Concept described as curved like a bow; describing an arc of a circle or that which winds around something; denotes several anatomical structures: arteries, veins, nerves, and muscles." }, { "input": "Concept: c-Jun N-terminal kinase cascade (stress-activated MAPK cascade)", "output": "something described as an intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." }, { "input": "Concept: Concomitant Medication Use End Relative to Reference Period (End Relative to Reference Period)", "output": "End Relative to Reference Period described as a characterization of the relationship of an concomitant medication use conclusion point in time to a reference point in time." }, { "input": "Concept: nucleoside metabolic process (glycosyl compound metabolic process)", "output": "something described as the chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." }, { "input": "Concept: Orchard Grass Pollen IgE (Immunoglobulin measurement)", "output": "Laboratory Procedure described as a measurement of the orchard grass (Dactylis glomerata) pollen IgE in a biological specimen." }, { "input": "Concept: disgust (Emotions)", "output": "Mental Process described as a feeling of revulsion or strong disapproval aroused by something unpleasant or offensive." }, { "input": "Concept: IVD Test Reagent/Kits, Immunoassay, Autoimmune, Diabetes, Insulin Autoantibody (Medical Device)", "output": "something described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine insulin autoantibodies (IAAs), which are commonly found in diabetic patients treated with exogenous (e.g., beef, pig) insulin. These antibodies are found in patients during the development of diabetes mellitus caused by autoimmune destruction of pancreatic beta-cell." }, { "input": "Concept: regulation of ribosomal RNA stability (regulation of RNA stability)", "output": "regulation of rRNA catabolic process described as any process that modulates the propensity of rRNA molecules to degradation. Includes processes that both stabilize and destabilize rRNAs." }, { "input": "Concept: Grade 1 AV Block-Second degree Mobitz Type I (Mobitz Type I, CTCAE)", "output": "something described as asymptomatic, intervention not indicated" }, { "input": "Concept: Multisubtype Natural Human Interferon Alpha (Pharmacologic Substance)", "output": "Pharmacologic Substance described as a preparation containing a mixture of multiple naturally occurring, active subtypes 1, 2, 8, 10, 14 and 21 of interferon alpha (IFN-alpha) with immunomodulating, anti-viral and anti-cancer activities. Multi-subtype natural human leukocyte IFN-alpha is purified from the leukocyte fraction of human blood challenged with Sendai virus. Upon administration, IFN-alpha subtypes bind to cell surface IFN-alpha receptors (IFNARs), resulting in an upregulation of interferon stimulated genes and related protein products. This ultimately leads to the proliferation of human B cells, activation of natural killer (NK) cells and dendritic cells (DCs), an increase in HLA-I and HLA-II expression and activation of CD8-lymphocytes. Compared to single-subtype IFN, multi-subtypes act synergistically." }, { "input": "Concept: hiccups were heard (Cerebral tissue perfusion status)", "output": "Cerebral tissue perfusion status described as a spasm of the diaphragm that causes a sudden inhalation followed by rapid closure of the glottis which produces a sound." }, { "input": "Concept: Rabbit Antithymocyte Globulin/Tacrolimus (Regimen Used to Treat or Prevent Graft Rejection)", "output": "something described as a regimen consisting of rabbit antithymocyte globulin and tacrolimus that can be used for the prevention and treatment of acute rejection following organ transplantation." }, { "input": "Concept: 177Lu-DOTA-JR11 (Pharmacologic Substance)", "output": "Amino Acid, Peptide, or Protein described as a radioconjugate consisting of the somatostatin antagonistic peptide satoreotide tetraxetan (JR11) that is linked, via the chelating agent dodecanetetraacetic acid (DOTA), to the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic activity and imaging activity during positron emission tomography/computed tomography (PET/CT). Upon administration, lutetium Lu 177-DOTA-JR11 binds to somatostatin receptors (SSTRs), with high affinity for SSTR2, present on the cell membranes of many types of neuroendocrine tumor (NET) cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to SSTR-positive cells. SSTRs have been shown to be present in large numbers on NETs and their metastases, while most normal tissues express low levels of SSTRs." }, { "input": "Concept: ZAKI-GLEESON SYNDROME (Autosomal recessive hereditary disorder)", "output": "Multiple malformation syndrome with facial-limb defects as major feature described as a rare genetic congenital anomalies/dysmorphic syndrome characterised by growth failure, global developmental delay, profound intellectual disability, autistic behaviour, acquired second-degree heart block with bradycardia and vasomotor instability. Hands and feet present with long fusiform fingers, campto-clinodactyly and crowded toes while craniofacial dysmorphism includes microcephaly, broad forehead, thin eyebrows, upslanting palpebral fissures, large ears with prominent antihelix, prominent nose, long philtrum, thin upper lip vermillion and prominent lower lip. Neurological signs include hypotonia, brisk reflexes, dystonic-like movements and truncal ataxia and imaging shows cerebellar hypoplasia and simplified gyral pattern." }, { "input": "Concept: ocellus photoreceptor cell development (Cell Function)", "output": "something described as development of photoreceptors, sensory cells that react to the presence of light, found in the ocellus." }, { "input": "Concept: Pyramidal tract, NOS (Cerebral tracts)", "output": "Cerebral tracts described as fibers that arise from cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord. Many authorities say the pyramidal tracts include both the corticospinal and corticobulbar tracts." }, { "input": "Concept: Mental retardation Smith Fineman Myers type (Genetic Diseases, X-Linked)", "output": "Dwarfism described as a rare syndrome of microcephaly, unusual facies, short stature, mental deficiency, and other dysmorphic features." }, { "input": "Concept: VACTERL syndrome with hydrocephalus (Hereditary disorder of nervous system)", "output": "Disease or Syndrome described as VACTERL is an acronym for Vertebral anomalies, Anal atresia, Congenital cardiac disease, Tracheo-oesophageal fistula, Renal anomalies, and Limb defects. VACTERL associated with hydrocephalus has rarely been reported and is thought to be an autosomal recessive anomaly. The condition is described as a uniformly lethal or developmentally devastating disorder distinct from the VATER association." }, { "input": "Concept: PQL1306 (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Questionnaire Question)", "output": "PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent Report for Teen (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen) In the past 7 days, how much of a problem has this been for your teen: My child's back feels stiff." }, { "input": "Concept: Brittle hair-impaired intellect-decreased fertility-short stature syndrome (Brittle hair)", "output": "Disease or Syndrome described as a trichothiodystrophy syndrome (sulfur-deficient brittle hair), short stature, mental deficiency poor sexual maturation, and infertility originally observed in the Amish kindred. This syndrome has the main characteristics of Tay syndrome (brittle hair, impaired intelligence, decreased fertility, and short stature), except for ichthyosis. Originally observed in an Amish family (hence its name) in Indiana, the syndrome was later reported in other groups, including a Moroccan family." }, { "input": "Concept: study start (Temporal Concept)", "output": "something described as the formal recognition of the beginning of a clinical trial that is referred to in the clinical study report." }, { "input": "Concept: lagging strand elongation involved in DNA replication involved in S phase involved in mitotic cell cycle (Genetic Function)", "output": "DNA strand elongation involved in mitotic DNA replication described as any lagging strand elongation that is involved in mitotic cell cycle DNA replication." }, { "input": "Concept: Erythroid Cells to Nucleated Cells Ratio Measurement (Blood Cell Count Ratio Measurement)", "output": "something described as the determination of the ratio of erythroid cells compared to nucleated cells present in a sample. The measurement may be expressed as a ratio or percentage." }, { "input": "Concept: Tuberculous Fibrosis of Lung (Pulmonary Fibrosis)", "output": "Soft Tissue Infection described as scarring of the lung parenchyma caused by pulmonary tuberculosis." }, { "input": "Concept: sodium chloride nose (Chlorine Compounds)", "output": "Electrolyte solutions described as a metal halide composed of sodium and chloride with sodium and chloride replacement capabilities. When depleted in the body, sodium must be replaced in order to maintain intracellular osmolarity, nerve conduction, muscle contraction and normal renal function." }, { "input": "Concept: Haemocyanin (Hemeproteins)", "output": "Blood Proteins described as metalloproteins that function as oxygen transport proteins in the HEMOLYMPH of MOLLUSKS and ARTHROPODS. They are characterized by two copper atoms, coordinated with HISTIDINE residues, that reversibly bind a single oxygen molecule; they do not contain HEME groups." }, { "input": "Concept: interleukin-37 biosynthetic process (Molecular Function)", "output": "cytokine biosynthesis described as the chemical reactions and pathways resulting in the formation of interleukin-37." }, { "input": "Concept: protein import into chloroplast thylakoid membrane (protein transmembrane import into intracellular organelle)", "output": "something described as the import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma." }, { "input": "Concept: positive regulation of kinetochore assembly (positive regulation of organelle assembly)", "output": "Cell Function described as any process that activates or increases the frequency, rate or extent of kinetochore assembly." }, { "input": "Concept: photopheresis (Therapeutic or Preventive Procedure)", "output": "Phototherapy described as a procedure which combines apheresis and photodynamic therapy, resulting in blood being treated with a photosensitizing agent and subsequently irradiated with specified wavelengths of light to achieve an effect." }, { "input": "Concept: 10p11.21 (Cell Component)", "output": "Chromosome band described as a chromosome band present on 10p" }, { "input": "Concept: FIF75 (Pulmonary function tests)", "output": "Pulmonary function tests described as the forced inspiratory flow rate at the point on the inspiratory flow-volume curve where 75 percent of the total volume of gas has been inhaled." }, { "input": "Concept: Nonlytic (Disease Laboratory Finding Qualifier)", "output": "Qualitative Concept described as in biology, refers to viruses that do not kill infected cells by disrupting their plasma membranes." }, { "input": "Concept: quinoline-2-carboxylate:acceptor 4-oxidoreductase (oxidoreductase activity, acting on the CH-CH group of donors)", "output": "Molecular Function described as catalysis of the reaction: A + H(2)O + quinaldate = AH(2) + kynurenate." }, { "input": "Concept: Left Main Coronary Artery Ostium (Cardiovascular System Part)", "output": "something described as the opening of the left coronary artery at its origin." }, { "input": "Concept: Stage IV Uterine Corpus Cancer AJCC v8 (Uterine Corpus Cancer by AJCC v8 Stage)", "output": "something described as stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Uterine corpus carcinoma or carcinosarcoma with tumor invading the bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, lung, liver, or bone. It excludes metastasis to pelvic or para-aortic lymph nodes, vagina, uterine serosa, or adnexa)." }, { "input": "Concept: Vantas Regimen (Regimen Used to Treat Prostate Carcinoma)", "output": "something described as a hormone therapy regimen consisting of histrelin that may be used in the treatment of prostate cancer." }, { "input": "Concept: Expression (Gene Expression Regulation)", "output": "Gene Expression Process described as typically involves transcription of genetically encoded information into an intermediary message (messenger RNA) and subsequent translation into a functional protein." }, { "input": "Concept: O antigen ligase activity (Molecular Function)", "output": "something described as catalysis of the reaction: Lipid A-core + colanic acid = MLPS." }, { "input": "Concept: internal sagittal stratum (Body Part, Organ, or Organ Component)", "output": "something described as a fiber tract within the cerebral white matter of the endbrain that contains fibers projecting from the occipital lobe to the superior colliculus and the lateral geniculate body. It is not readily distinguished in myelin-stained cross-sections ( Carpenter-1983 )." }, { "input": "Concept: nephric duct development (kidney epithelium development)", "output": "something described as the process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney." }, { "input": "Concept: Herpes Simplex Virus 1/2 IgG Antibody (Immunologic Tests)", "output": "Laboratory Procedure described as the determination of the amount of Herpes Simplex virus 1/2 IgG antibody present in a sample." }, { "input": "Concept: Neoplasm of the Cranial Nerve (Peripheral Nervous System Neoplasms)", "output": "Head and Neck Neoplasms described as benign and malignant neoplasms that arise from one or more of the twelve cranial nerves." }, { "input": "Concept: inhibition of host IRF7 by virus (suppression by virus of host transcription)", "output": "suppression by virus of host molecular function described as any process in which a virus stops, prevents, or reduces the activity of host IRF7 (interferon regulatory factor-7), a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes." }, { "input": "Concept: Lip and Oral Cavity Cancer pN2 TNM Finding v7 (Lip and Oral Cavity Cancer Pathologic Regional Lymph Nodes TNM Finding v7)", "output": "Lip and Oral Cavity Cancer Pathologic Regional Lymph Nodes TNM Finding v7 described as lip and oral cavity cancer with metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension." }, { "input": "Concept: TIVIRAPINE (Nucleic Acid, Nucleoside, or Nucleotide)", "output": "something described as a benzodiazepine non-nucleoside reverse transcriptase inhibitor with activity against human immunodeficiency viruses 1 and 2 and simian immunodeficiency virus. Tivirapine inhibits replication in both wild-type and drug-resistant HIV-1 isolates." }, { "input": "Concept: C8:0 (FATTY ACIDS, LIPIDS AND LIPOPROTEINS)", "output": "Pharmacologic Substance described as a saturated medium-chain fatty acid with an 8-carbon backbone. Octanoic acid is found naturally in the milk of various mammals and is a minor component of coconut oil and palm kernel oil." }, { "input": "Concept: up regulation by symbiont of cytolysis of host cells (Organism Function)", "output": "positive regulation of cytolysis in other organism involved in symbiotic interaction described as any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." }, { "input": "Concept: Differentiated and Anaplastic Thyroid Carcinoma TNM Finding v8 (Finding)", "output": "Thyroid Carcinoma TNM Finding v8 described as a finding about one or more characteristics of papillary, follicular, Hurthle cell, poorly differentiated, and anaplastic (undifferentiated) thyroid carcinoma, following the rules of the TNM AJCC v8 classification system. Medullary thyroid cancers are staged according to the classification for thyroid-medullary. Thyroid lymphomas are staged according to the classification for Hodgkin and non-Hodgkin lymphoma. There are no AJCC staging systems for thyroid cancer arising from thyroglossal duct cyst and thyroid cancer in malignant struma ovarii." }, { "input": "Concept: down regulation of phosphatidylserine exposure on apoptotic cell surface (regulation of phosphatidylserine exposure on apoptotic cell surface)", "output": "Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface." }, { "input": "Concept: Tea (Plant Preparations)", "output": "something described as dried leaves or infusions of the tea plant, Camellia sinensis, containing caffeine, theophylline, tannic acid and volatile oil; do not confuse with herbal tea; for this, see cross references for herbal tea." }, { "input": "Concept: 6q13 (Cell Component)", "output": "Cell Component described as a chromosome band present on 6q." }, { "input": "Concept: PQL0609 (PedsQL Neuromuscular Module Version 3.0 Parent Report for Child Questionnaire Question)", "output": "something described as pediatric Quality of Life Neuromuscular Module Version 3.0 Parent Report for Child (PedsQL Neuromuscular Module Version 3.0 Parent Report for Child) In the past one month, how much of a problem has this been for your child: It is hard for my child to use the bathroom." }, { "input": "Concept: Juvenile Hyalinosis (Skin Diseases, Genetic)", "output": "Myofibromatosis described as autosomal recessive disorder characterized by HYALINE deposition in the skin, bone, gastrointestinal tract, muscles and glands; multiple subcutaneous skin nodules; GINGIVAL HYPERTROPHY; and joint CONTRACTURES. Mutations in the capillary morphogenesis protein-2 are associated with the disorder." }, { "input": "Concept: opsonization (immune effector process)", "output": "immune effector process described as the process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody." }, { "input": "Concept: Pediatric Immature Teratoma of Ovary (Childhood Immature Teratoma)", "output": "Neoplastic Process described as an immature teratoma that arises from the ovary and occurs in children." }, { "input": "Concept: main cingulate gyrus (Body Part, Organ, or Organ Component)", "output": "Body Part, Organ, or Organ Component described as applies to the gyrus closer to the corpus callosum in the approximately 35% of humans who have a double cingulate gyrus. It parallels the external cingulate gyrus from which it is separated by the cingulate sulcus. It is bounded internally by the callosal sulcus ( Vogt-1995 )." }, { "input": "Concept: Anti-TLR2 Monoclonal Antibody OPN-305 (Amino Acid, Peptide, or Protein)", "output": "Pharmacologic Substance described as a humanized immunoglobulin (Ig) G4 monoclonal antibody directed against toll-like receptor type 2 (TLR2), with potential anti-inflammatory and antineoplastic activities. Upon intravenous administration, OPN-305 binds to the ligand-binding site on the TLR2 receptor and blocks the activation of TLR2-mediated innate immunity signaling. This prevents the TLR2-mediated production of pro-inflammatory mediators and prevents inflammation. TLR2, a member of the TLR family primarily found on leukocytes, plays a key role in the activation of innate immunity; it is overexpressed in various inflammatory diseases and in certain types of cancer. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C120554\" active clinical trials using this agent." }, { "input": "Concept: Pitt syndrome (Disease or Syndrome)", "output": "something described as short stature, characteristic facies, microcephaly, telecanthus, prominent eyes, abnormal slanting of the palpebral fissures, hypoplastic maxilla, short philtrum, large mouth, and severe mental retardation." }, { "input": "Concept: lutetium Lu 177-DOTA-edotreotide (ANTINEOPLASTIC RADIOPHARMACEUTICALS)", "output": "Pharmacologic Substance described as a radioconjugate consisting of the somatostatin analogue edotreotide labeled with lutetium Lu 177 with potential antineoplastic activities. Lutetium Lu 177-edotreotide binds to somatostatin receptors (SSTRs), with high affinity to type 2 SSTR, present on the cell membranes of many types of neuroendocrine tumor cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to SSTR-positive cells. Edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of the somatostatin analogue octreotide (Tyr3-octreotide or TOC) and chelated by the bifunctional, macrocyclic chelating agent dodecanetetraacetic acid (DOTA). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C88277\" active clinical trials using this agent." }, { "input": "Concept: Retinopathy of Prematurity in Zone 1 (Retinopathy of Prematurity Finding)", "output": "Retinopathy of Prematurity Finding described as retinopathy of prematurity located in zone 1 of the retina." }, { "input": "Concept: fos Genes (Gene or Genome)", "output": "Gene or Genome described as retrovirus-associated DNA sequences (fos) originally isolated from the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses. The proto-oncogene protein c-fos codes for a nuclear protein which is involved in growth-related transcriptional control. The insertion of c-fos into FBJ-MSV or FBR-MSV induces osteogenic sarcomas in mice. The human c-fos gene is located at 14q21-31 on the long arm of chromosome 14." }, { "input": "Concept: pre-IC complex assembly involved in mitotic cell cycle (mitotic cell cycle process)", "output": "Molecular Function described as any DNA replication preinitiation complex assembly that is involved in mitotic cell cycle." }, { "input": "Concept: Silver point (Biomedical or Dental Material)", "output": "something described as an endodontic silver point is a device made of silver intended for use during endodontic therapy to fill permanently the root canal of a tooth." }, { "input": "Concept: Grade 2 Scleral disorder (Finding)", "output": "Scleral Disorder, CTCAE described as symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline); limiting instrumental ADL" }, { "input": "Concept: Neuropharmacology (Neuroscience discipline)", "output": "Neuroscience discipline described as study of the origin, nature, properties, and actions of drugs and their effects on the nervous system; use this term mainly for intended, desired effects; for harmful or undesired effects, see NEUROTOXICOLOGY." }, { "input": "Concept: glomerular development (Organ or Tissue Function)", "output": "something described as the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment." }, { "input": "Concept: Blasts More than 20 Percent of Peripheral Blood White Cells (Blasts 20 Percent or More of Peripheral Blood White Cells)", "output": "something described as a semi-quantitative microscopic finding indicating that more than 20 percent of the nucleated cells in a peripheral leukocyte sample are immature mononuclear cells." }, { "input": "Concept: Alternatives, Animal Testing (Animal Use Alternatives)", "output": "Study models described as procedures, such as TISSUE CULTURE TECHNIQUES; mathematical models; etc., when used or advocated for use in place of the use of animals in research or diagnostic laboratories." }, { "input": "Concept: Ustilago (Pers.) Roussel, 1806 (Ustilaginales)", "output": "Ustilaginaceae described as any fungal organism that is not assigned to the species level but can be assigned to the Ustilago genus level." }, { "input": "Concept: Invasive Species (Population Group)", "output": "Population Group described as non-native species that threaten ecosystems, habitats, or other species and are likely to cause economic or environmental harm or harm to human health." }, { "input": "Concept: Renal salt-wasting (Kidney)", "output": "Finding described as a high concentration of one or more electrolytes in the urine in the presence of low serum concentrations of the electrolyte(s)." }, { "input": "Concept: Affordabilities (Quantitative Concept)", "output": "Quantitative Concept described as the cost of goods or services in context of the expected benefit for the consumer and the means available to that consumer." }, { "input": "Concept: acetaldehyde:NAD+ oxidoreductase (Molecular Function)", "output": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor described as catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+." }, { "input": "Concept: retinal:NAD+ oxidoreductase activity (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)", "output": "Molecular Function described as catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal." }, { "input": "Concept: Deoxypyridinoline Measurement (Protein or Enzyme Type Measurement)", "output": "Pyridinoline measurement described as the determination of the amount of deoxypyridinoline present in a sample." }, { "input": "Concept: paramomycin sulfate (Antibiotics, Aminoglycoside)", "output": "Antibiotics, Aminoglycoside described as the sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria. Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47652\" active clinical trials using this agent." }, { "input": "Concept: Warfare (Warfare and Armed Conflicts)", "output": "something described as methods of conducting ARMED CONFLICTS." }, { "input": "Concept: LEC0117F (LEC-5 Standard Version Questionnaire Question)", "output": "something described as life Events Checklist for DSM-5, Standard Version - Any other very stressful event or experience: Doesn't apply." }, { "input": "Concept: Skin structure of neck (Segment of skin of body proper)", "output": "Neck described as the integumentary covering of the neck." }, { "input": "Concept: Scleromyxoedema (Protein deposition)", "output": "Diffuse cutaneous mucinosis described as a connective tissue disorder characterized by widespread thickening of SKIN with a cobblestone-like appearance. It is caused by proliferation of FIBROBLASTS and deposition of MUCIN in the DERMIS in the absence of thyroid disease. Most scleromyxedema cases are associated with a MONOCLONAL GAMMOPATHY, immunoglobulin IgG-lambda." }, { "input": "Concept: PQL0502 (PedsQL Neuromuscular Module Version 3.0 Child Report Questionnaire Question)", "output": "PedsQL Neuromuscular Module Version 3.0 Child Report Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Version 3.0 Child Report (PedsQL Neuromuscular Module Version 3.0 Child Report) In the past one month, how much of a problem has this been for you: I get sick easily." }, { "input": "Concept: drynaria/gu sui bu (Oriental herbs and natural substances letter D)", "output": "Plant described as gu sui bu" }, { "input": "Concept: Intrauterine Exposure (Exposure to)", "output": "Pathologic Function described as the exposure to agents that occurs during in utero development." }, { "input": "Concept: Venous (Specific site descriptor)", "output": "something described as of, or pertaining to, or contained in, or performing the function of the veins." }, { "input": "Concept: Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group Protein (Amino Acid, Peptide, or Protein)", "output": "Amino Acid, Peptide, or Protein described as a family of DNA repair proteins." }, { "input": "Concept: IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Carbohydrate Antigen CA 27.29 (Medical Device)", "output": "Medical Device described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine CA 27.29, a carbohydrate-related tumor marker. The detection of the tumor marker CA 27.29 is mostly used in monitoring therapy and disease progression in metastatic breast cancer, but not to diagnose primary breast cancer." }, { "input": "Concept: Grade 1 Neonatal Hypotension, AE (Finding)", "output": "Neonatal Hypotension, Adverse Event described as an adverse event in a newborn characterized by transient (less than 60 minutes), asymptomatic hypotension; not affecting perfusion; not requiring intervention." }, { "input": "Concept: Dependent Variables (Variable)", "output": "Intellectual Product described as in an experimental modification of independent factors, the factors that are anticipated to alter as a result." }, { "input": "Concept: PQL0413 (Intellectual Product)", "output": "something described as pediatric Quality of Life Neuromuscular Module Version 3.0 Parent Report for Teen (PedsQL Neuromuscular Module Version 3.0 Parent Report for Teen) In the past one month, how much of a problem has this been for your teen: It takes my child a long time to bathe or shower." }, { "input": "Concept: response to dextromethorphan (drug response)", "output": "drug response described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus." }, { "input": "Concept: Chiro-Inositol (Alcohols)", "output": "Carbohydrates described as a natural sugar found in cell membrane phospholipids, plasma lipoproteins, and (as the phosphate form) in the nucleus with potential chemopreventive properties. As one of a number of intracellular phosphate compounds, inositol is involved in cell signaling and may stimulate tumor cell differentiation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28163\" active clinical trials using this agent." }, { "input": "Concept: PQL13-Money Problem in Our Family (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Questionnaire Question)", "output": "something described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Teen Parent Report - In the past 7 days, how much of a problem has this been for your teen: I think money is a problem in our family." }, { "input": "Concept: BALBX (Body Substance)", "output": "Biopsy sample described as tissue removed from the bronchi and alveoli for microscopic examination." }, { "input": "Concept: Endocarditis, Infective (Heart valve disease)", "output": "Pulmonary Valve Disorder described as endocarditis that is caused by an infectious agent." }, { "input": "Concept: OAB-q Short Form - Caused Problems with Your Partner or Spouse (Intellectual Product)", "output": "Intellectual Product described as the Overactive Bladder Questionnaire Short Form - Caused you to have problems with your partner or spouse?" }, { "input": "Concept: hluPGFS (Gene or Genome)", "output": "Gene or Genome described as human AKR1C3 wild-type allele is located within 10p15-p14 and is approximately 72 kb in length. This allele, which encodes aldo-keto reductase family 1 member C3 protein, plays a role in the metabolism of prostaglandins and steroids." }, { "input": "Concept: B1 cell group (serotonergic cell groups)", "output": "something described as a group of cells fluorescent for serotonin that occupies the midline nucleus raphe pallidus and adjacent structures in the caudal medulla of the rodent ( Dahlstrom-1964 ) and the primate ( Felten-1983 )." }, { "input": "Concept: TSCYC1TN (CDISC Questionnaire Terminology)", "output": "CDISC Questionnaire Terminology described as test names of questionnaire questions associated with the Trauma Symptom Checklist for Young Children (TSCYC) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." }, { "input": "Concept: Every thirty six hours (Schedule Frequency)", "output": "Temporal Concept described as every thirty-six hours." }, { "input": "Concept: petal vascular tissue pattern formation (xylem and phloem pattern formation)", "output": "Organ or Tissue Function described as vascular tissue pattern formation as it occurs in the petal of vascular plants." }, { "input": "Concept: Risk for situational low self-esteem (Finding)", "output": "something described as susceptible to developing a negative perception of self-worth in response to a current situation, which may compromise health." }, { "input": "Concept: Benign Adrenal Gland Composite Pheochromocytoma (Adrenal Gland Composite Pheochromocytoma)", "output": "Neoplastic Process described as a composite pheochromocytoma that is confined to the adrenal gland and does not have any metastatic potential." }, { "input": "Concept: CS (Term Type)", "output": "Intellectual Product described as the NCI term type designation for a US State Department standard country code." }, { "input": "Concept: Corsican (Language)", "output": "Romance language described as a Romance language within the Italo-Dalmatian subfamily spoken mainly in Corsica and northern Sardinia." }, { "input": "Concept: Impairments, Cognitive (Learning Disorders & Mental Retardation)", "output": "Thesaurus of Psychological Index Terms described as diminished mental function." }, { "input": "Concept: DESULFOVIBRIO DESULFURICANS (Desulfovibrio)", "output": "Desulfovibrio described as a species of anaerobic, Gram negative, rod shaped bacterium assigned to the phylum Proteobacteria. This species is motile by single polar flagellum, reduces sulfate and is catalase positive. D. desulfuricans is an infrequent pathogen and may be important in manufacturing for the bioreduction of metals including Uranium and Palladium. Phenotypically, it is indistinguishable from Desulfovibrio fairfieldensis." }, { "input": "Concept: 1H-indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2-alpha,6-alpha,8-alpha,9a-beta)- (Organic Chemical)", "output": "Serotonin-3 Receptor Antagonist [EPC] described as the active ingredient in a drug used to treat nausea and vomiting caused by cancer treatment. Dolasetron is a type of serotonin receptor antagonist and a type of antiemetic." }, { "input": "Concept: Haploinsufficiencies (Loss of Heterozygosity)", "output": "Cell or Molecular Dysfunction described as a copy number variation that results in reduced GENE DOSAGE due to any loss-of-function mutation. The loss of heterozygosity is associated with abnormal phenotypes or diseased states because the remaining gene is insufficient." }, { "input": "Concept: 1p36.1-p35 (Chromosome band)", "output": "Chromosome band described as a chromosome band present on 1p" }, { "input": "Concept: FANA +, diffuse or homogeneous (Finding)", "output": "Laboratory Findings: Serology, FANA described as FANA (Fluorescent Antinuclear Antibody): a test in which standard nuclei are washed with patient serum and then stained with fluorescent labeled antihuman globulin. The pattern of staining may suggest different connective tissue diseases, e.g., 1) diffuse pattern, found in many diseases; 2) rim pattern, more suggestive of SLE; 3) speckled pattern, suggestive of MCTD, SLE and others; nucleolar pattern, suggestive of PSS." }, { "input": "Concept: Major Histocompatibility Complex, Class I-Related wt Allele (MR1 gene)", "output": "Gene or Genome described as human MR1 wild-type allele is located in the vicinity of 1q25.3 and is approximately 29 kb in length. This allele, which encodes major histocompatibility complex class I-related gene protein, is involved in antigen presentation in the gut." }, { "input": "Concept: Insurance, Pharmaceutical services (Health Care Related Organization)", "output": "Health Care Related Organization described as insurance providing for payment of services rendered by the pharmacist. Services include the preparation and distribution of medical products." }, { "input": "Concept: Overview of telomerase protein component gene hTert Transcriptional Regulation (Molecular Function)", "output": "Regulatory Pathway described as telomerase is an enzyme that replicates the terminal sequences of eukaryotic chromosomes, namely the telomeres. Cells that have an unlimited replicative capacity, such as male germ cells and the majority of human cancers, have high levels of telomerase activity. The level and frequency of telomerase activity in more than 85% of all cancers highlights the critical role telomerase plays in tumor progression. Telomerase activation is the most common general marker for a cancer cell to date making it an attractive target for new cancer diagnostics and therapeutics. Human telomerase activity can be reconstituted in vitro by the essential RNA subunit, hTERC, and the catalytic protein component coded for by the hTERT gene. Both the human telomerase reverse transcriptase gene (hTERT) and the telomerase RNA gene (hTERC) are controlled at least in part at the transcriptional level. The hTERT gene is expressed at low levels in cancer cells and is generally undetectable in normal cells." }, { "input": "Concept: SMAD, Mothers Against DPP Homolog 6 Gene (Gene or Genome)", "output": "SMAD6 gene described as human SMAD6 wild-type allele is located within 15q21-q22 and is approximately 80 kb in length. This allele, which encodes mothers against decapentaplegic homolog 6 protein, plays a role in the regulation of both heart and blood vessel development and maintenance." }, { "input": "Concept: AVL01-List A 30 Min Delay Recall Word 14 (Intellectual Product)", "output": "ADNI-AVLT Questionnaire Question described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) List A, 30 Minute Delay Recall, Word 14." }, { "input": "Concept: Providing chromium based on suboptimal food or fluid intake, iatrogenic deficiency or medical diagnosis. (Mineral supplementation)", "output": "something described as providing chromium based on suboptimal food or fluid intake, iatrogenic deficiency or medical diagnosis." }, { "input": "Concept: HPV45 (Virus)", "output": "human papillomavirus described as a virus comprised of a protein coat (capsid) surrounding a circular, double-stranded DNA organized into coding and non-coding regions, which can induce epithelial lesions. Infection with human papillomavirus-45 is associated with a high risk for cervical intraepithelial neoplasia." }, { "input": "Concept: membrane addition at site of cytokinesis (Cell Function)", "output": "cytokinetic process described as any process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion." }, { "input": "Concept: Gelastic seizure (Disease or Syndrome)", "output": "Seizure undetermined whether focal or generalized described as focal emotional seizure with laughing (gelastic) is characterized by bursts of laughter or giggling, usually without appropriate related emotion of happiness, and described as 'mirthless'." }, { "input": "Concept: interleukin-21 production (cytokine production)", "output": "something described as the appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." }, { "input": "Concept: Line Probe Assay (Laboratory Procedure)", "output": "something described as a microbial identification technique in which polymerase chain reaction is used to amplify specific nucleic acid sequences in a biospecimen. The product of this reaction is then applied to a nitrocellulose test strip containing complementary DNA probes." }, { "input": "Concept: Prescapular lymph node (Upper limb lymph node structure)", "output": "Prescapular lymph node group described as a lymph node located in front of the shoulder." }, { "input": "Concept: Laminar Air Flow Units, Fixed, Surgical (Medical Device)", "output": "something described as air-handling apparatus for a surgical operating room is a device intended to produce a directed, nonturbulent flow of air that has been filtered to remove particulate matter and microorganisms to provide an area free of contaminants to reduce the possibility of infection in the patient." }, { "input": "Concept: chambers hyperbaric (controlled environment chamber)", "output": "Therapeutic Device described as chambers designed for patient treatment in which the air pressure is raised more than two times above the atmospheric pressure while the patient breathes near 100% medical grade oxygen. The elevated ambient pressure of the hyperbaric chamber reduces the size of gas bubbles trapped in vascular beds and accelerates their dissipation. Circulation is thereby restored to tissue in which the blood supply has been blocked or compromised. Typically, pure oxygen is delivered for patient breathing, either by a mask or hood or by oxygen pressurization of monoplace chambers. Hyperbaric chambers are used to treat any condition in which gas bubbles form in the blood, including pulmonary and cerebral air embolism, altitude and decompression sickness, and less frequently iatrogenic gas embolism that may occur during hospital procedures." }, { "input": "Concept: TCF 4 Transcription Factor (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors)", "output": "something described as a basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder." }, { "input": "Concept: teams (Organizations & Organizational Behavior)", "output": "Population Group described as two or more people working together." }, { "input": "Concept: steroid 5alpha-reductase (Molecular Function)", "output": "steroid dehydrogenase activity, acting on the CH-CH group of donors described as catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor." }, { "input": "Concept: P-Cell Stimulating Factor (Interleukins)", "output": "Colony-Stimulating Factors described as a multilineage cell growth factor secreted by LYMPHOCYTES; EPITHELIAL CELLS; and ASTROCYTES which stimulates clonal proliferation and differentiation of various types of blood and tissue cells." }, { "input": "Concept: Nevus of Ota (Mass of eye structure)", "output": "Ocular neoplasms malignancy unspecified described as a macular lesion on the side of the FACE, involving the CONJUNCTIVA and EYELIDS, as well as the adjacent facial skin, SCLERA; OCULOMOTOR MUSCLES; and PERIOSTEUM. Histological features vary from those of a MONGOLIAN SPOT to those of a BLUE NEVUS." }, { "input": "Concept: Biomarker Analysis (Laboratory Procedure)", "output": "something described as a method of biological assay that looks for the presence of unique molecules or sequences considered indicative for a condition or state." }, { "input": "Concept: IFNL4 Gene (Cytokine Gene)", "output": "Gene or Genome described as this gene plays a role in antiviral responses and JAK-STAT pathway activation." }, { "input": "Concept: Squalus acanthias Linnaeus, 1758 (Squalidae)", "output": "something described as a species of shark in the family SQUALIDAE, used for its oil (SQUALENE) and as fish meal. It also figures heavily in biological research, especially with reference to its RECTAL GLAND in studies of WATER-ELECTROLYTE BALANCE." }, { "input": "Concept: NPI1D09 (Intellectual Product)", "output": "NPI Questionnaire Question described as neuropsychiatric Inventory - Frequency of the depression/dysphoria." }, { "input": "Concept: thyroiditis autoimmune (Autoimmune endocrine disease)", "output": "Autoimmune Diseases described as an inflammatory disorder that affects the thyroid gland. It is characterized by the infiltration of the thyroid parenchyma by lymphocytes. It includes Hashimoto thyroiditis and subacute lymphocytic thyroiditis." }, { "input": "Concept: IVD Test Reagent/Kits, Serology, Virus, Retrovirus, Human T-Cell Lymphotropic Virus-I/II (Medical Device)", "output": "IVD Test Reagent/Kits, Serology, Virus, Retrovirus, Human T-Cell Lymphotropic Virus-I described as serology reagents intended to detect and/or identify antigens or serum antibody titers to human T-cell lymphotropic virus (also called human T-cell leukemia/lymphoma virus) type I (HTLV-I) and/or type 2 (HTLV-II). Human T-cell lymphotropic retroviruses are tumor-producing RNA viruses of the subfamily Oncovirinae that may cause chronic infection, T-cell leukemia, tropical paraparesis (chronic progressive myelopathy), and other hematological diseases." }, { "input": "Concept: hippocampal neuron apoptotic process (Apoptosis of neurons)", "output": "Cell Function described as any apoptotic process that occurs in a hippocampal neuron." }, { "input": "Concept: interhemispheric transfer (Mental Process)", "output": "something described as transfer of information between cerebral hemispheres." }, { "input": "Concept: cerebrum (Body Part, Organ, or Organ Component)", "output": "Gray Matter described as derived from TELENCEPHALON, cerebrum is composed of a right and a left hemisphere. Each contains an outer cerebral cortex and a subcortical basal ganglia. The cerebrum includes all parts within the skull except the MEDULLA OBLONGATA, the PONS, and the CEREBELLUM. Cerebral functions include sensorimotor, emotional, and intellectual activities." }, { "input": "Concept: Investigational New Drug (Drug Approval)", "output": "something described as data submitted to an investigational new human drug application." }, { "input": "Concept: resection of liver (Hepatic therapeutic procedures)", "output": "Biopsy of abdominal wall described as surgery to remove all or part of the liver." }, { "input": "Concept: Macedonia, Yugoslavia (Yugoslavia)", "output": "Yugoslavia described as country in Europe, east of Albania and north of Greece. The capital is Skopje. In June, 2018 agreement was reached to establish the new name Republic of North Macedonia.which became effective February 2019." }, { "input": "Concept: GAIA Level 1 Neonatal Respiratory Distress (Intellectual Product)", "output": "something described as GAIA Level 1 Neonatal Respiratory Distress is defined by four criteria: first, the newborn must be between 0 and 28 days of life; second, the presence of any one of the following three symptoms that indicate an abnormal respiratory rate: a) Tachypnea (respiratory rate of 60 or more breaths per minute); b) Bradypnea (respiratory rate of less than 30 breaths per minute); c) Apnea [cessation of respiratory effort (no breaths) for at least 20 seconds]; third, one of the following five clinical symptoms that indicate labored breathing: a) Nasal flaring (dilatation of alae nasi); b) Noisy respirations in the form of expiratory grunting, stridor, or wheeze; c) Retractions or increased chest indrawings on inspiration (subcostal, intercostal, sternal, suprasternal notch); d) Central cyanosis (whole body, including lips and tongue) on room air; e) Low Apgar score (less than 7 points) at 10 minutes, with respiration score less than 2; fourth, examination and documentation by qualified, trained health care providers who are appropriate for the clinical setting." }, { "input": "Concept: animals wild (Animal Population Groups)", "output": "Animals described as animals considered to be wild or feral or not adapted for domestic use; prefer indexing specific animal, treed elsewhere, when possible." }, { "input": "Concept: Limb duplication (Duplication of whole limb)", "output": "Congenital Abnormality described as congenital duplication of all or part of a limb. []" }, { "input": "Concept: CDISC Questionnaire GAD-7 Test Name Terminology (Intellectual Product)", "output": "Intellectual Product described as generalized Anxiety Disorder - 7 test name." }, { "input": "Concept: Positive Displacement Pipettors (Medical Device)", "output": "something described as pipettors designed for automated or semi-automated transfer of programmed volumes of liquids from one container to another container by displacing a plunger in a cylinder or capillary tube that makes direct contact with the liquid. These pipettors include a plunger that is displaced to a given position to set the volume of liquid to be transferred; then a control button is depressed to expel the same volume of air from the tube. After immersion of the pipettor tip into the liquid, the control button is released to create a partial vacuum that aspirates an identical volume of the transferred liquid through the tip and into the pipetter until the liquid makes direct contact to the plunger. Single-channel and multichannel positive displacement pipettors are used in clinical laboratories; they improve the precision of measurements and lessen the possibility of cross-contamination among samples when compared with manual pipetting procedures." }, { "input": "Concept: transcription regulatory region sequence-specific DNA binding (Genetic Function)", "output": "sequence-specific double-stranded DNA binding described as interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." }, { "input": "Concept: Nnspcfd HCPCS ADL dvc ref cd (Tracking code use with or without ICD diagnosis)", "output": "Health Care Activity described as mapping the practitioner type or specialty to an activities of daily living assistance device, equipment or supply code. Use associated HCPCS II codes to bill for activities of daily living device(s), equipment or supply(ies). This code is used for scope-of-practice mapping, not for billing." }, { "input": "Concept: Autosomal recessive spastic paraplegia type 45 (Spastic Paraplegia, Hereditary)", "output": "Spastic paraplegia type 5A, recessive described as a rare pure or complex form of hereditary spastic paraplegia with characteristics of onset in infancy of progressive lower limb spasticity, abnormal gait, increased deep tendon reflexes and extensor plantar responses that may be associated with intellectual disability. Additional signs such as contractures in the lower limbs, amyotrophy, clubfoot and optic atrophy, have also been reported. Caused by homozygous mutation in the NT5C2 gene on chromosome 10q24." }, { "input": "Concept: 12-Methoxyibogamine (Secologanin Tryptamine Alkaloids)", "output": "Biologically Active Substance described as indole alkaloid with antidepressant and euphoric properties; appears to modulate tolerance to opiates." }, { "input": "Concept: peptidyl-S-carbamoyl-L-cysteine dehydration (Molecular Function)", "output": "peptidyl-cysteine modification described as the dehydration of peptidyl-S-carbamoyl-L-cysteine to form peptidyl-S-cyano-L-cysteine." }, { "input": "Concept: Flexure line of skin (Body Space or Junction)", "output": "Anatomical line of skin described as *Anatomical line of skin, the course, of which, is modulated by the action of underlying joints." }, { "input": "Concept: ubiquitin-dependent protein catabolic process via the N-end rule pathway (proteasome-mediated ubiquitin-dependent protein catabolic process)", "output": "proteasome-mediated ubiquitin-dependent protein catabolic process described as the chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation." }, { "input": "Concept: Sutures, Synthetic, Absorbable, Polyhydroxybutyrate, Monofilament (Polyhydroxybutyrate suture)", "output": "something described as synthetic sutures made of polyhydroxybutyrate, an absorbable (i.e., biodegradable) biosynthetic polymer. These sutures are typically available in sterile monofilament sections (e.g., 18, 30 inches/45, 76 cm long), which may be attached to a single-use needle as an integral device. They are frequently colored for easy identification during surgery. Polyhydroxybutyrate sutures keep their tensile strength for up to 12 weeks and complete absorption occurs by 12 to 18 months. Their intended use includes general soft-tissue approximation in applications requiring prolonged suture strength retention and suture flexibility." }, { "input": "Concept: Rhabdoid tumour predisposition syndrome (Hereditary Diseases)", "output": "Autosomal dominant hereditary disorder described as a neoplastic syndrome most often caused by mutations in the hSNF5/INI1 tumor suppressor gene. It is characterized by the development of an atypical teratoid/rhabdoid tumor in infancy and early childhood. This highly aggressive tumor develops in the central nervous system as an isolated lesion or in combination with extrarenal or renal rhabdoid tumor. Patients may also develop other central nervous system malignancies including medulloblastoma, supratentorial primitive neuroectodermal tumor, and choroid plexus carcinoma. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C93268\" active clinical trials using this agent." }, { "input": "Concept: Granules and solvent for suspension for injection (Combined Dosage Form)", "output": "Combined Dosage Form described as sterile granules and sterile solvent intended for the preparation of a suspension for injection by dispersing the granules in the solvent." }, { "input": "Concept: Health Care Professionals (Professional or Occupational Group)", "output": "Report Source described as all service providers working within the context of the health system, such as doctors, nurses, physiotherapists, occupational therapists, speech therapists, audiologists, orthotist-prosthetists, medical social workers." }, { "input": "Concept: Pathways, Transcytotic (Cell Function)", "output": "something described as the mechanisms by which materials are transported through cells." }, { "input": "Concept: Dressing Dosing Unit (Potency Unit)", "output": "Quantitative Concept described as a unit of presentation used to represent the quantity of product that is found in a single discrete entity where the pharmaceutical dose form is a type of dressing." }, { "input": "Concept: CNS tumor, pediatric supratentorial ependymoma (Brain Ependymoma)", "output": "Childhood Ependymoma described as an ependymoma that arises from the supratentorial region of the brain and occurs during childhood." }, { "input": "Concept: Interstitial Fluid (Body Substance)", "output": "Transudate described as the fluid in spaces between the tissue cells, constituting about 16% of the weight of the body; closely similar in composition to LYMPH. (On-Line Medical Dictionary [Internet]. University of Newcastle upon Tyne (UK): The CancerWEB Project, Academic Medical Publishing; c1997-2003 [cited 2003 May 1]. Available from: http://cancerweb.ncl.ac.uk/omd/.)" }, { "input": "Concept: Developments, Sustainable (Conservation of Natural Resources)", "output": "Conservation of Natural Resources described as a process of change in which the exploitation of resources, the direction of investments, the orientation of technological development; and institutional change are all in harmony and enhance both current and future potential to meet human needs and aspirations." }, { "input": "Concept: vascular smooth muscle cell dedifferentiation (cell dedifferentiation involved in phenotypic switching)", "output": "Organ or Tissue Function described as the process in which a vascular smooth muscle cell (a non-striated, elongated, spindle-shaped cell found lining the blood vessels) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." }, { "input": "Concept: SUBSTANCE P (Neurotransmitters)", "output": "Neurotransmitters & Neuroregulators described as neuropeptide composed of 11 amino acids, present in nerve cells scattered throughout the body and in special endocrine cells in the gut; increases the contractions of gastrointestinal smooth muscle, causes vasodilation, and appears to be a sensory neurotransmitter mediating pain, touch, and temperature." }, { "input": "Concept: MOREASND (Idea or Concept)", "output": "Idea or Concept described as the rationale why a morphology test was not performed." }, { "input": "Concept: CAMERA, STILL, ENDOSCOPIC (Medical Device)", "output": "something described as a surgical camera and accessories is a device intended to be used to record operative procedures." }, { "input": "Concept: SGRQ-C - Cough (SGRQ-C Questionnaire Question)", "output": "Intellectual Product described as st. George's Respiratory Questionnaire - I cough." }, { "input": "Concept: negative regulation of blood coagulation, intrinsic pathway (negative regulation of blood coagulation)", "output": "Biologic Function described as any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, intrinsic pathway." }, { "input": "Concept: mitral valve morphogenesis (Organism Function)", "output": "something described as the process in which the structure of the mitral valve is generated and organized." }, { "input": "Concept: p48 Subunit, Chromatin Assembly Factor-1 (Sin3 Histone Deacetylase and Corepressor Complex)", "output": "something described as a retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2." }, { "input": "Concept: (1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol Hydrochloride (Golgi Alpha-Mannosidase II Inhibitor)", "output": "Pharmacologic Substance described as an orally-active synthetic hydrochloride salt form of swainsonine, an inhibitor of Golgi alpha-mannosidase II. Tridolgosir inhibits formation of carbohydrate structures affecting cell-cell adhesion, resulting in decreases in tumor growth or metastasis. This agent also stimulates the immune system." }, { "input": "Concept: Spectrophotometers, Atomic Absorption (Medical Device)", "output": "Medical Device described as an atomic absorption spectrophotometer for clinical use is a device intended to identify and measure elements and metals (e.g., lead and mercury) in human specimens. The metal elements are identified according to the wavelength and intensity of the light that is absorbed when the specimen is converted to the atomic vapor phase. Measurements obtained by this device are used in the diagnosis and treatment of certain conditions." }, { "input": "Concept: isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process (Molecular Function)", "output": "isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway described as the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway that contributes to terpenoid biosynthesis. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate." }, { "input": "Concept: DRRI1K01 (DRRI-2 Questionnaire Question)", "output": "DRRI-2 Questionnaire Question described as deployment Risk and Resilience Inventory-2 (DRRI-2) During deployment, the people I worked with: treated me in an overly critical way." }, { "input": "Concept: Bile, NOS (Body Substance)", "output": "Gallbladder described as fluid composed of waste products, bile acids, salts, cholesterol, and electrolytes. It is secreted by the liver parenchyma and stored in the gallbladder." }, { "input": "Concept: imaginal disc-derived male genitalia development (imaginal disc-derived genitalia development)", "output": "Biologic Function described as the process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." }, { "input": "Concept: Age Which Participant Stopped Smoking (Clinical or Research Assessment Answer)", "output": "something described as the chronological age at which an individual stopped smoking." }, { "input": "Concept: Hilar Cholangiocarcinoma TNM Finding v8 (Finding)", "output": "Hepatobiliary System Cancer TNM Finding v8 described as a finding about one or more characteristics of perihilar bile duct cancer, following the rules of the TNM AJCC v8 classification system. This staging system applies to perihilar cholangiocarcinomas. Well-differentiated neuroendocrine tumors and sarcomas are not staged using this staging system." }, { "input": "Concept: CSS1015C (C-SSRS Pediatric Cognitively Impaired Lifetime Recent Questionnaire Question)", "output": "C-SSRS Pediatric Cognitively Impaired Lifetime Recent Questionnaire Question described as columbia-Suicide Severity Rating Scale Pediatric/Cognitively Impaired Lifetime/Recent (C-SSRS Pediatric/Cognitively Impaired Lifetime/Recent) Description of aborted or self-interrupted attempt." }, { "input": "Concept: 19: 54149929-54156867 (Spatial Concept)", "output": "Spatial Concept described as physical location of BAX_Gene" }, { "input": "Concept: engineer genetic (Genetic Techniques)", "output": "Genetic Techniques described as the application of genetic-based biotechnology to modify the characteristics of an organism by cutting, splicing, and transferring genetic materials, especially DNA, from one or more species of organism." }, { "input": "Concept: WHODAS 2.0 36-item Version Interviewer-administered - Earn Less Money (WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question)", "output": "something described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Interviewer-administered (WHODAS 2.0 36-item Version Interviewer-administered) Because of your health condition, in the past 30 days how much difficulty did you have in: Did you earn less money as the result of a health condition?" }, { "input": "Concept: SDTM-PFTEST (CDISC SDTM Terminology)", "output": "something described as terminology relevant to the test names that describe pharmacogenomics findings." }, { "input": "Concept: ERT - Happiness Responded as Disgust (Intellectual Product)", "output": "Intellectual Product described as emotion Recognition Test (ERT) Number of happiness stimuli responded to as disgust." }, { "input": "Concept: regulation of protein localization to membrane (regulation of cellular protein localization)", "output": "something described as any process that modulates the frequency, rate or extent of protein localization to membrane." }, { "input": "Concept: Fibrae reticuloolivares (Body Part, Organ, or Organ Component)", "output": "Body Part, Organ, or Organ Component described as fibers that enter the central tegmental tract at various levels in the vicinity of the red nucleus, and the central gray substance, the pontine reticular formation and the midbrain reticular formation and terminate in the inferior olive ( Kahle-2001 )." }, { "input": "Concept: N-acetylmuramate catabolic process (amino sugar catabolic process)", "output": "N-acetylmuramic acid metabolic process described as the chemical reactions and pathways resulting in the breakdown of N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine." }, { "input": "Concept: Tumour of surface epithelium (Neoplastic Process)", "output": "Neoplastic Process described as a benign, premalignant, or malignant neoplasm that arises from epithelial cells and involves the skin." }, { "input": "Concept: SEARL ULCER (Infected ulcer of skin)", "output": "Skin and soft tissue atypical mycobacterial infection described as a lesion in the skin and subcutaneous tissues due to infections by MYCOBACTERIUM ULCERANS. It was first reported in Uganda, Africa." }, { "input": "Concept: up regulation of methane biosynthetic process from carbon monoxide (positive regulation of cellular respiration)", "output": "positive regulation of cellular respiration described as any process that activates or increases the frequency, rate or extent of methane biosynthetic process from carbon monoxide." }, { "input": "Concept: Sulocarbilate (Organic Chemical)", "output": "something described as a sulfanilamide derivative and carbonic anhydrase inhibitor with diuretic activity." }, { "input": "Concept: rhodopsin (Retinal Pigments)", "output": "Retinal Pigments described as a red pigment localized in the outer segments of rod cells in the retina." }, { "input": "Concept: phosphinothricin N-acetyltransferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)", "output": "transferase activity, transferring acyl groups other than amino-acyl groups described as catalysis of the reaction: acetyl-CoA + phosphinothricin <=> H+ + coenzyme A(4-) + N-acetylphosphinatothricinate." }, { "input": "Concept: Community disaster readiness status (Finding)", "output": "Readiness described as community preparedness to respond to a natural or man-made calamitous event" }, { "input": "Concept: Stage III Carcinoma of the Hypopharynx AJCC v6 (Stage III Pharynx Carcinoma)", "output": "Hypopharyngeal cancer stage NOS described as stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension or with fixation of hemilarynx. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis." }, { "input": "Concept: PRCC (Neoplasms)", "output": "Papillary adenocarcinoma described as also known as chromophil carcinoma, it represents a minority of renal cell carcinomas. It can be hereditary or sporadic. The sporadic papillary renal cell carcinoma is characterized by trisomy of chromosomes 7, 16, and 17, and loss of chromosome Y. The peak incidence is in the sixth and seven decades. It is classified as type 1 or 2, based on the cytoplasmic volume and the thickness of the lining neoplastic cells. The prognosis is more favorable than for conventional (clear cell) renal cell carcinoma." }, { "input": "Concept: IVD Panels, Human Genetics, Eye Disorder, Glaucoma, Comprehensive, Mutation (IVD Panels, Human Genetics, Eye Disorder, Glaucoma, Comprehensive)", "output": "Medical Device described as molecular assay reagents intended to identify mutations in the majority of genes known to be associated with glaucoma, a collection of diseases that lead to optic nerve damage. Genetic variants at multiple loci have been associated with glaucoma. These reagents are intended to detect mutations in multiple glaucoma-associated loci simultaneously." }, { "input": "Concept: Spherocytosis Gene Panel Reagents (Medical Device)", "output": "IVD Panels, Human Genetics, Blood Disorder, Hemolytic Anemia described as molecular assay reagents intended to identify gene variants associated with spherocytosis, a form of hemolytic anemia characterized by spherical red blood cells. Genetic variants at multiple loci have been associated with spherocytosis. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) multiple spherocytosis-associated loci simultaneously." }, { "input": "Concept: SVN53-67/M57-KLH Peptide Vaccine (Vaccines, Peptide)", "output": "Vaccines, Peptide described as a peptide vaccine containing a 15-mer peptide (DLAQMFFCFKELEGW), with C to M alteration at amino acid position 57, derived from the anti-apoptosis protein survivin, and conjugated with keyhole limpet hemocyanin (KLH), with potential immunopotentiating and antineoplastic activities. Upon subcutaneous administration of SVN53-67/M57-KLH peptide vaccine, this peptide is able to bind both HMC class I and II molecules and may activate the immune system to mount a cytotoxic T-lymphocyte (CTL) as well as a T-helper cell response against survivin-expressing cancer cells. This may result in decreased tumor cell proliferation and ultimately tumor cell death. Survivin, a member of the inhibitor of apoptosis (IAP) family, expressed during embryonic development while absent in most normal adult cells, is upregulated in a variety of human cancers; its expression in tumors is associated with a more aggressive phenotype, decreased survival, and increased resistance to chemotherapy. KLH may enhance immune recognition and may promote an enhanced response. As SVN53-67 is weakly immunogenic in humans, the M57 alteration may lead to greater affinity towards HLA-A*0201 and thus an enhanced antitumor immune response." }, { "input": "Concept: climb stairs (Clinical or Research Assessment Question)", "output": "Clinical or Research Assessment Question described as a question about an individual's ability to walk up stairs." }, { "input": "Concept: Adoptive Parent (parent)", "output": "something described as a parent in the parent-child relationship established by a legal adoption proceeding." }, { "input": "Concept: Partial inversion (Finding)", "output": "something described as a finding of partial inversion of epiglottis during swallowing." }, { "input": "Concept: DefinedObservation.focalDateRange (Focal Date Range)", "output": "something described as the time period in which the observation result is held to be true, expressed either as a simple date range or as an evaluable expression that references a study-defined date or milestone. EXAMPLE(S): For a survey question, \"Have you traveled to Europe between 1990 and 1999?\", the focalDateRange would be \"January 1, 1990 to December 31, 1999\".For the question, \"Have you smoked in the last 2 months\", the focalDateRange would be an expression referencing a variable that represents the PerformedObservation.actualDateRange (a value yet to be defined) and a formula for the date range between when the question is asked (PerformedObservation.actualDateRange.low) and 2 months prior (PerformedObservation.actualDateRange.low - 2 months). NOTE(S): As an attribute with data type EXPRIVLTS.DATETIME, focalDateRange can be used to express a simple date range such as \"January 1, 1990 to December 31, 1999\" or a relative time expression that includes a variable that represents another date in the model that is a study-defined anchor point. The other date may or may not be known at the time the DefinedObservation is created, but will be known by the time the PerformedObservation is created." }, { "input": "Concept: brain control (Psychology)", "output": "Mental Process described as external, coercive persuasion of behavior by biomedical, physical, psychological, or social means, generally for nontherapeutic reasons; involves inducing or urging the adoption of certain beliefs, theories, or lines of action by others; do not confuse with perception that something else has determined the outcome of a circumstance, for this concept refer to LOCUS OF CONTROL." }, { "input": "Concept: Refrigerators, Pharmacy, Walk-In (Pharmacy refrigerator)", "output": "Medical Device described as pharmacy refrigerators with a cabinet-like storage compartment large enough to permit a person to enter; they are designed for storage of drugs, pharmacy preparations, and other pharmaceutical products (e.g., live virus vaccines) typically at temperatures between 2 and 10 degrees Celsius (35 and 50 degrees Fahrenheit). These refrigerators typically consist of a chamber made with a corrosion-resistant (typically stainless steel) interior, minimizing the risk of adulteration, contamination, and/or corrosion of contents; internal shelving appropriate for storage, easy location, and handling of laboratory products once the user is inside the chamber; a compressor, condenser, evaporator, tubing, sensors, controls, monitors, a temperature recording chart, and alarms for a dependable long-term storage following pharmacy standards. Walk-in pharmacy refrigerators are available completely assembled or as separate structural elements (e.g., doors, panels, floors) and units (e.g., refrigeration system, condensing unit) for assembly at user facilities." }, { "input": "Concept: Idiopathic eosinophilia-associated myopathy (Eosinophilic myositis)", "output": "Eosinophilic myositis described as a rare skeletal muscle disease with characteristics of eosinophilic infiltration and inflammatory lesions of the skeletal muscle tissue in the absence of an identifiable causative factor (for example parasitic infection, drug intake, systemic or malignant disease). Clinically patients may present focal or generalised muscle weakness and pain, difficulties with walking, motor clumsiness, as well as elevated serum creatine kinase levels and peripheral blood and/or bone marrow hypereosinophilia." } ] }