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2442bc0
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2d4d893
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- mutant/activity/3FCR_activity-substrate-1.csv +69 -69
- mutant/activity/3FCR_activity-substrate-2.csv +69 -69
- mutant/activity/P0A873_vmax.csv +48 -48
- mutant/activity/P27346_activity_PBO.csv +12 -12
- mutant/activity/P27346_activity_PTO.csv +11 -11
- mutant/activity/P27346_activity_aKG.csv +11 -11
- mutant/activity/Q51559_activity.csv +113 -113
- mutant/dti_binding/BindingDB_P41145_214799_Ki.csv +1 -1
- mutant/dti_binding/BindingDB_Q873X9_10854_Kd.csv +1 -1
- mutant/ppi_binding/PPB_Affinity_1AO7_D_kd.csv +1 -1
- mutant/ppi_binding/PPB_Affinity_1MI5_D_kd.csv +1 -1
- mutant/ppi_binding/PPB_Affinity_1OGA_E_kd.csv +8 -8
- mutant/selectivity/ACCO_ee.csv +11 -11
- mutant/stability/M1261_1BNI_A_ddG.csv +29 -29
- mutant/stability/M1261_1C9O_A_ddG.csv +12 -12
- mutant/stability/M1261_1CSP_A_ddG.csv +31 -31
- mutant/stability/M1261_1EY0_A_ddG.csv +233 -233
- mutant/stability/M1261_1LNI_A_ddG.csv +17 -17
- mutant/stability/M1261_1LRP_A_ddG.csv +20 -20
- mutant/stability/M1261_1RN1_C_ddG.csv +9 -9
- mutant/stability/M1261_1RTB_A_ddG.csv +10 -10
- mutant/stability/M1261_1SHG_A_ddG.csv +28 -28
- mutant/stability/M1261_2AFG_A_ddG.csv +29 -29
- mutant/stability/M1261_2CI2_I_ddG.csv +6 -6
- mutant/stability/M1261_2H6X_A_ddG.csv +7 -7
- mutant/stability/M1261_2LZM_A_ddG.csv +85 -85
- mutant/stability/M1261_2RN2_A_ddG.csv +19 -19
- mutant/stability/M1261_451C_A_ddG.csv +10 -10
- mutant/stability/M1261_5PTI_A_ddG.csv +8 -8
- mutant/stability/S4346_1AKY_dTm.csv +7 -7
- mutant/stability/S4346_1BNI_dTm.csv +44 -44
- mutant/stability/S4346_1BVC_dTm.csv +38 -38
- mutant/stability/S4346_1EY0_dTm.csv +145 -145
- mutant/stability/S4346_1HRC_dTm.csv +11 -11
- mutant/stability/S4346_1KF2_dTm.csv +68 -68
- mutant/stability/S4346_1LNI_dTm.csv +66 -66
- mutant/stability/S4346_1LZ1_dTm.csv +133 -133
- mutant/stability/S4346_1RN1_dTm.csv +42 -42
- mutant/stability/S4346_1SHG_dTm.csv +6 -6
- mutant/stability/S4346_1WQ5_dTm.csv +49 -49
- mutant/stability/S4346_2CI2_dTm.csv +27 -27
- mutant/stability/S4346_2LZM_dTm.csv +0 -0
- mutant/stability/S4346_2RN2_dTm.csv +74 -74
- mutant/stability/S4346_3MBP_dTm.csv +7 -7
- mutant/stability/S4346_3SSI_dTm.csv +22 -22
- mutant/stability/S4346_451C_dTm.csv +8 -8
- mutant/stability/S4346_4LYZ_dTm.csv +45 -45
- mutant/stability/S4346_5PTI_dTm.csv +75 -75
- mutant/stability/S4346_P03040_dTm.csv +12 -12
- mutant/stability/S4346_P0CG48_dTm.csv +12 -12
mutant/activity/3FCR_activity-substrate-1.csv
CHANGED
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@@ -1,69 +1,69 @@
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| 1 |
-
mutant,fitness_score
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| 2 |
-
L58V,0.003
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| 3 |
-
M1M,0.001
|
| 4 |
-
T231A,0.0193
|
| 5 |
-
T231A:Y59F,0.091
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| 6 |
-
T231A:Y59W,0.338
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| 7 |
-
T231L,0.032
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| 8 |
-
T231L:S19W,0.009
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| 9 |
-
Y152F,0.0017
|
| 10 |
-
Y59W,0.1901
|
| 11 |
-
Y87C:S19V,0.0137
|
| 12 |
-
Y87C:S19W:T231L,0.0137333333333333
|
| 13 |
-
Y87C:S19W:T231L:Y59W,0.0534
|
| 14 |
-
Y87F,0.004
|
| 15 |
-
Y87F:S19G:T231A:Y59W,0.1468
|
| 16 |
-
Y87F:S19T:T231A:Y59W,0.2306
|
| 17 |
-
Y87F:S19W:T231A:Y59W,0.279325
|
| 18 |
-
Y87F:S19W:T231L,0.0793
|
| 19 |
-
Y87F:T231A:Y59L:Y152F,0.0073
|
| 20 |
-
Y87F:T231A:Y59W,1.4
|
| 21 |
-
Y87F:T231A:Y59W:Y152F,1.04
|
| 22 |
-
Y87F:T231A:Y59W:Y152F:L58A,0.498
|
| 23 |
-
Y87F:T231A:Y59W:Y152F:L58V,0.7775
|
| 24 |
-
Y87F:T231A:Y59W:Y152F:S19F,0.0954
|
| 25 |
-
Y87F:T231G:Y59F,0.12
|
| 26 |
-
Y87F:T231G:Y59W,0.1319
|
| 27 |
-
Y87F:T231L:Y59W:Y152F,0.0574
|
| 28 |
-
Y87F:T231L:Y59W:Y152F:S19F,0.0335
|
| 29 |
-
Y87F:Y152F,0.0529
|
| 30 |
-
Y87H:S19W:T231L,0.0168
|
| 31 |
-
Y87L,0.0448
|
| 32 |
-
Y87L:S19A,0.0424
|
| 33 |
-
Y87L:S19F:T231A:Y59W,0.1485
|
| 34 |
-
Y87L:S19F:T231A:Y59W:F168M,0.2797
|
| 35 |
-
Y87L:S19F:T231A:Y59W:F168W,0.3128
|
| 36 |
-
Y87L:S19F:T231A:Y59W:F55L,0.0511
|
| 37 |
-
Y87L:S19F:T231A:Y59W:F55M,0.0525
|
| 38 |
-
Y87L:S19F:T231A:Y59W:L167V,0.2913
|
| 39 |
-
Y87L:S19V,0.0359
|
| 40 |
-
Y87L:S19W,0.0645
|
| 41 |
-
Y87L:S19W:T231A,0.0852
|
| 42 |
-
Y87L:S19W:T231A:Y59W,0.3495
|
| 43 |
-
Y87L:S19W:T231H,0.0041
|
| 44 |
-
Y87L:S19W:T231L,0.0359333333333333
|
| 45 |
-
Y87L:S19W:T231L:Y59W,0.20925
|
| 46 |
-
Y87L:S19W:T231M,0.0656
|
| 47 |
-
Y87L:S19W:T231Q,0.0126
|
| 48 |
-
Y87L:S19W:T231S,0.0441
|
| 49 |
-
Y87L:S19W:Y152F,0.041
|
| 50 |
-
Y87L:T231A,0.0309
|
| 51 |
-
Y87L:T231A:Y59W,0.4024
|
| 52 |
-
Y87L:T231A:Y59W:L167V,1.1884
|
| 53 |
-
Y87L:T231A:Y59W:L382M,0.4847
|
| 54 |
-
Y87L:T231A:Y59W:S86A,0.774
|
| 55 |
-
Y87L:T231A:Y59W:S86A:L382M,1.0405
|
| 56 |
-
Y87L:T231A:Y59W:Y152F,0.2285
|
| 57 |
-
Y87L:T231A:Y59W:Y152F:L382M,0.4089
|
| 58 |
-
Y87L:T231G,0.0244
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| 59 |
-
Y87L:T231G:Y59W,0.0664
|
| 60 |
-
Y87L:Y152F,0.0287
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| 61 |
-
Y87L:Y152F:S155A,0.0187
|
| 62 |
-
Y87N:S19W:T231L,0.0023
|
| 63 |
-
Y87Q:S19W:T231L,0.0168
|
| 64 |
-
Y87Q:T231A:Y59W,0.3183
|
| 65 |
-
Y87T:S19W:T231L,0.0138
|
| 66 |
-
Y87V:S19V,0.0197
|
| 67 |
-
Y87V:T231A:Y59W,0.1448
|
| 68 |
-
Y87W:S19V,0.0002
|
| 69 |
-
Y87W:T231A:Y59W,0.1159
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|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
L58V,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGVYCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.003
|
| 3 |
+
M1M,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.001
|
| 4 |
+
T231A,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0193
|
| 5 |
+
T231A:Y59F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLFCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.091
|
| 6 |
+
T231A:Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.338
|
| 7 |
+
T231L,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.032
|
| 8 |
+
T231L:S19W,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.009
|
| 9 |
+
Y152F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0017
|
| 10 |
+
Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.1901
|
| 11 |
+
Y87C:S19V,MLKNDQLDQWDRDNFFHPVTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSCVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0137
|
| 12 |
+
Y87C:S19W:T231L,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSCVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0137333333333333
|
| 13 |
+
Y87C:S19W:T231L:Y59W,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSCVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0534
|
| 14 |
+
Y87F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.004
|
| 15 |
+
Y87F:S19G:T231A:Y59W,MLKNDQLDQWDRDNFFHPGTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.1468
|
| 16 |
+
Y87F:S19T:T231A:Y59W,MLKNDQLDQWDRDNFFHPTTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.2306
|
| 17 |
+
Y87F:S19W:T231A:Y59W,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.279325
|
| 18 |
+
Y87F:S19W:T231L,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0793
|
| 19 |
+
Y87F:T231A:Y59L:Y152F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLLCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0073
|
| 20 |
+
Y87F:T231A:Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,1.4
|
| 21 |
+
Y87F:T231A:Y59W:Y152F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,1.04
|
| 22 |
+
Y87F:T231A:Y59W:Y152F:L58A,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGAWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.498
|
| 23 |
+
Y87F:T231A:Y59W:Y152F:L58V,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGVWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.7775
|
| 24 |
+
Y87F:T231A:Y59W:Y152F:S19F,MLKNDQLDQWDRDNFFHPFTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0954
|
| 25 |
+
Y87F:T231G:Y59F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLFCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGGGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.12
|
| 26 |
+
Y87F:T231G:Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGGGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.1319
|
| 27 |
+
Y87F:T231L:Y59W:Y152F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0574
|
| 28 |
+
Y87F:T231L:Y59W:Y152F:S19F,MLKNDQLDQWDRDNFFHPFTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0335
|
| 29 |
+
Y87F:Y152F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0529
|
| 30 |
+
Y87H:S19W:T231L,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSHVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0168
|
| 31 |
+
Y87L,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0448
|
| 32 |
+
Y87L:S19A,MLKNDQLDQWDRDNFFHPATHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0424
|
| 33 |
+
Y87L:S19F:T231A:Y59W,MLKNDQLDQWDRDNFFHPFTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.1485
|
| 34 |
+
Y87L:S19F:T231A:Y59W:F168M,MLKNDQLDQWDRDNFFHPFTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELMHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.2797
|
| 35 |
+
Y87L:S19F:T231A:Y59W:F168W,MLKNDQLDQWDRDNFFHPFTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELWHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.3128
|
| 36 |
+
Y87L:S19F:T231A:Y59W:F55L,MLKNDQLDQWDRDNFFHPFTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDALAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0511
|
| 37 |
+
Y87L:S19F:T231A:Y59W:F55M,MLKNDQLDQWDRDNFFHPFTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAMAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0525
|
| 38 |
+
Y87L:S19F:T231A:Y59W:L167V,MLKNDQLDQWDRDNFFHPFTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLEVFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.2913
|
| 39 |
+
Y87L:S19V,MLKNDQLDQWDRDNFFHPVTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0359
|
| 40 |
+
Y87L:S19W,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0645
|
| 41 |
+
Y87L:S19W:T231A,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0852
|
| 42 |
+
Y87L:S19W:T231A:Y59W,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.3495
|
| 43 |
+
Y87L:S19W:T231H,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGHGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0041
|
| 44 |
+
Y87L:S19W:T231L,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0359333333333333
|
| 45 |
+
Y87L:S19W:T231L:Y59W,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.20925
|
| 46 |
+
Y87L:S19W:T231M,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGMGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0656
|
| 47 |
+
Y87L:S19W:T231Q,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGQGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0126
|
| 48 |
+
Y87L:S19W:T231S,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGSGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0441
|
| 49 |
+
Y87L:S19W:Y152F,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.041
|
| 50 |
+
Y87L:T231A,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0309
|
| 51 |
+
Y87L:T231A:Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.4024
|
| 52 |
+
Y87L:T231A:Y59W:L167V,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLEVFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,1.1884
|
| 53 |
+
Y87L:T231A:Y59W:L382M,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLMCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.4847
|
| 54 |
+
Y87L:T231A:Y59W:S86A,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHALVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.774
|
| 55 |
+
Y87L:T231A:Y59W:S86A:L382M,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHALVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLMCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,1.0405
|
| 56 |
+
Y87L:T231A:Y59W:Y152F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.2285
|
| 57 |
+
Y87L:T231A:Y59W:Y152F:L382M,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLMCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.4089
|
| 58 |
+
Y87L:T231G,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGGGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0244
|
| 59 |
+
Y87L:T231G:Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGGGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0664
|
| 60 |
+
Y87L:Y152F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0287
|
| 61 |
+
Y87L:Y152F:S155A,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGAGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0187
|
| 62 |
+
Y87N:S19W:T231L,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSNVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0023
|
| 63 |
+
Y87Q:S19W:T231L,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSQVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0168
|
| 64 |
+
Y87Q:T231A:Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSQVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.3183
|
| 65 |
+
Y87T:S19W:T231L,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSTVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0138
|
| 66 |
+
Y87V:S19V,MLKNDQLDQWDRDNFFHPVTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSVVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0197
|
| 67 |
+
Y87V:T231A:Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSVVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.1448
|
| 68 |
+
Y87W:S19V,MLKNDQLDQWDRDNFFHPVTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSWVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0002
|
| 69 |
+
Y87W:T231A:Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSWVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.1159
|
mutant/activity/3FCR_activity-substrate-2.csv
CHANGED
|
@@ -1,69 +1,69 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
L58V,0.0117
|
| 3 |
-
M1M,0.0163
|
| 4 |
-
T231A,0.0501
|
| 5 |
-
T231A:Y59F,0.0632
|
| 6 |
-
T231A:Y59W,0.056
|
| 7 |
-
T231L,0.0022
|
| 8 |
-
T231L:S19W,-0.0002
|
| 9 |
-
Y152F,0.0294
|
| 10 |
-
Y59W,0.1156
|
| 11 |
-
Y87C:S19V,0.0807
|
| 12 |
-
Y87C:S19W:T231L,0.0038666666666666
|
| 13 |
-
Y87C:S19W:T231L:Y59W,0.0013
|
| 14 |
-
Y87F,0.1238
|
| 15 |
-
Y87F:S19G:T231A:Y59W,0.0639
|
| 16 |
-
Y87F:S19T:T231A:Y59W,0.1993
|
| 17 |
-
Y87F:S19W:T231A:Y59W,0.449825
|
| 18 |
-
Y87F:S19W:T231L,0.0423
|
| 19 |
-
Y87F:T231A:Y59L:Y152F,0.0176
|
| 20 |
-
Y87F:T231A:Y59W,0.5
|
| 21 |
-
Y87F:T231A:Y59W:Y152F,1.17
|
| 22 |
-
Y87F:T231A:Y59W:Y152F:L58A,0.0377
|
| 23 |
-
Y87F:T231A:Y59W:Y152F:L58V,0.2636
|
| 24 |
-
Y87F:T231A:Y59W:Y152F:S19F,0.3935
|
| 25 |
-
Y87F:T231G:Y59F,0.1272
|
| 26 |
-
Y87F:T231G:Y59W,0.0599
|
| 27 |
-
Y87F:T231L:Y59W:Y152F,0.0207
|
| 28 |
-
Y87F:T231L:Y59W:Y152F:S19F,0.0352
|
| 29 |
-
Y87F:Y152F,0.3036
|
| 30 |
-
Y87H:S19W:T231L,0.014
|
| 31 |
-
Y87L,0.2631
|
| 32 |
-
Y87L:S19A,0.1474
|
| 33 |
-
Y87L:S19F:T231A:Y59W,0.0508
|
| 34 |
-
Y87L:S19F:T231A:Y59W:F168M,0.0399
|
| 35 |
-
Y87L:S19F:T231A:Y59W:F168W,0.1276
|
| 36 |
-
Y87L:S19F:T231A:Y59W:F55L,0.0179
|
| 37 |
-
Y87L:S19F:T231A:Y59W:F55M,0.0272
|
| 38 |
-
Y87L:S19F:T231A:Y59W:L167V,0.0443
|
| 39 |
-
Y87L:S19V,0.2195
|
| 40 |
-
Y87L:S19W,0.1253
|
| 41 |
-
Y87L:S19W:T231A,0.0532
|
| 42 |
-
Y87L:S19W:T231A:Y59W,0.0419
|
| 43 |
-
Y87L:S19W:T231H,0.0142
|
| 44 |
-
Y87L:S19W:T231L,0.0145333333333333
|
| 45 |
-
Y87L:S19W:T231L:Y59W,0.0058
|
| 46 |
-
Y87L:S19W:T231M,0.0152
|
| 47 |
-
Y87L:S19W:T231Q,0.02725
|
| 48 |
-
Y87L:S19W:T231S,0.0368
|
| 49 |
-
Y87L:S19W:Y152F,0.0703
|
| 50 |
-
Y87L:T231A,0.0355
|
| 51 |
-
Y87L:T231A:Y59W,0.0917
|
| 52 |
-
Y87L:T231A:Y59W:L167V,0.1772
|
| 53 |
-
Y87L:T231A:Y59W:L382M,0.0145
|
| 54 |
-
Y87L:T231A:Y59W:S86A,0.0703
|
| 55 |
-
Y87L:T231A:Y59W:S86A:L382M,0.075
|
| 56 |
-
Y87L:T231A:Y59W:Y152F,0.0513
|
| 57 |
-
Y87L:T231A:Y59W:Y152F:L382M,0.0836
|
| 58 |
-
Y87L:T231G,0.024
|
| 59 |
-
Y87L:T231G:Y59W,0.0241
|
| 60 |
-
Y87L:Y152F,0.1674
|
| 61 |
-
Y87L:Y152F:S155A,0.0449
|
| 62 |
-
Y87N:S19W:T231L,0.0008
|
| 63 |
-
Y87Q:S19W:T231L,0.0364
|
| 64 |
-
Y87Q:T231A:Y59W,0.1276
|
| 65 |
-
Y87T:S19W:T231L,0.0076
|
| 66 |
-
Y87V:S19V,0.0709
|
| 67 |
-
Y87V:T231A:Y59W,0.0513
|
| 68 |
-
Y87W:S19V,0.003
|
| 69 |
-
Y87W:T231A:Y59W,0.0601
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
L58V,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGVYCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0117
|
| 3 |
+
M1M,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0163
|
| 4 |
+
T231A,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0501
|
| 5 |
+
T231A:Y59F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLFCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0632
|
| 6 |
+
T231A:Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.056
|
| 7 |
+
T231L,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0022
|
| 8 |
+
T231L:S19W,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,-0.0002
|
| 9 |
+
Y152F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0294
|
| 10 |
+
Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.1156
|
| 11 |
+
Y87C:S19V,MLKNDQLDQWDRDNFFHPVTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSCVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0807
|
| 12 |
+
Y87C:S19W:T231L,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSCVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0038666666666666
|
| 13 |
+
Y87C:S19W:T231L:Y59W,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSCVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0013
|
| 14 |
+
Y87F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.1238
|
| 15 |
+
Y87F:S19G:T231A:Y59W,MLKNDQLDQWDRDNFFHPGTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0639
|
| 16 |
+
Y87F:S19T:T231A:Y59W,MLKNDQLDQWDRDNFFHPTTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.1993
|
| 17 |
+
Y87F:S19W:T231A:Y59W,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.449825
|
| 18 |
+
Y87F:S19W:T231L,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0423
|
| 19 |
+
Y87F:T231A:Y59L:Y152F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLLCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0176
|
| 20 |
+
Y87F:T231A:Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.5
|
| 21 |
+
Y87F:T231A:Y59W:Y152F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,1.17
|
| 22 |
+
Y87F:T231A:Y59W:Y152F:L58A,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGAWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0377
|
| 23 |
+
Y87F:T231A:Y59W:Y152F:L58V,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGVWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.2636
|
| 24 |
+
Y87F:T231A:Y59W:Y152F:S19F,MLKNDQLDQWDRDNFFHPFTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.3935
|
| 25 |
+
Y87F:T231G:Y59F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLFCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGGGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.1272
|
| 26 |
+
Y87F:T231G:Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGGGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0599
|
| 27 |
+
Y87F:T231L:Y59W:Y152F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0207
|
| 28 |
+
Y87F:T231L:Y59W:Y152F:S19F,MLKNDQLDQWDRDNFFHPFTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0352
|
| 29 |
+
Y87F:Y152F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSFVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.3036
|
| 30 |
+
Y87H:S19W:T231L,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSHVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.014
|
| 31 |
+
Y87L,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.2631
|
| 32 |
+
Y87L:S19A,MLKNDQLDQWDRDNFFHPATHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.1474
|
| 33 |
+
Y87L:S19F:T231A:Y59W,MLKNDQLDQWDRDNFFHPFTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0508
|
| 34 |
+
Y87L:S19F:T231A:Y59W:F168M,MLKNDQLDQWDRDNFFHPFTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELMHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0399
|
| 35 |
+
Y87L:S19F:T231A:Y59W:F168W,MLKNDQLDQWDRDNFFHPFTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELWHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.1276
|
| 36 |
+
Y87L:S19F:T231A:Y59W:F55L,MLKNDQLDQWDRDNFFHPFTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDALAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0179
|
| 37 |
+
Y87L:S19F:T231A:Y59W:F55M,MLKNDQLDQWDRDNFFHPFTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAMAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0272
|
| 38 |
+
Y87L:S19F:T231A:Y59W:L167V,MLKNDQLDQWDRDNFFHPFTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLEVFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0443
|
| 39 |
+
Y87L:S19V,MLKNDQLDQWDRDNFFHPVTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.2195
|
| 40 |
+
Y87L:S19W,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.1253
|
| 41 |
+
Y87L:S19W:T231A,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0532
|
| 42 |
+
Y87L:S19W:T231A:Y59W,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0419
|
| 43 |
+
Y87L:S19W:T231H,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGHGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0142
|
| 44 |
+
Y87L:S19W:T231L,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0145333333333333
|
| 45 |
+
Y87L:S19W:T231L:Y59W,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0058
|
| 46 |
+
Y87L:S19W:T231M,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGMGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0152
|
| 47 |
+
Y87L:S19W:T231Q,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGQGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.02725
|
| 48 |
+
Y87L:S19W:T231S,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGSGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0368
|
| 49 |
+
Y87L:S19W:Y152F,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0703
|
| 50 |
+
Y87L:T231A,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0355
|
| 51 |
+
Y87L:T231A:Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0917
|
| 52 |
+
Y87L:T231A:Y59W:L167V,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLEVFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.1772
|
| 53 |
+
Y87L:T231A:Y59W:L382M,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLMCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0145
|
| 54 |
+
Y87L:T231A:Y59W:S86A,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHALVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0703
|
| 55 |
+
Y87L:T231A:Y59W:S86A:L382M,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHALVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLMCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.075
|
| 56 |
+
Y87L:T231A:Y59W:Y152F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0513
|
| 57 |
+
Y87L:T231A:Y59W:Y152F:L382M,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLMCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0836
|
| 58 |
+
Y87L:T231G,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGGGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.024
|
| 59 |
+
Y87L:T231G:Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGGGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0241
|
| 60 |
+
Y87L:Y152F,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.1674
|
| 61 |
+
Y87L:Y152F:S155A,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSLVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGFHGAGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0449
|
| 62 |
+
Y87N:S19W:T231L,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSNVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0008
|
| 63 |
+
Y87Q:S19W:T231L,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSQVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0364
|
| 64 |
+
Y87Q:T231A:Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSQVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.1276
|
| 65 |
+
Y87T:S19W:T231L,MLKNDQLDQWDRDNFFHPWTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSTVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGLGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0076
|
| 66 |
+
Y87V:S19V,MLKNDQLDQWDRDNFFHPVTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSVVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0709
|
| 67 |
+
Y87V:T231A:Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSVVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0513
|
| 68 |
+
Y87W:S19V,MLKNDQLDQWDRDNFFHPVTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQARELAYYHSWVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.003
|
| 69 |
+
Y87W:T231A:Y59W,MLKNDQLDQWDRDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLWCVNVGYGRQEIAEAIADQARELAYYHSWVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLIWYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGAGGIVPPPAGYWEAIQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRAEADQVVEGTLRAVKAVLG,0.0601
|
mutant/activity/P0A873_vmax.csv
CHANGED
|
@@ -1,48 +1,48 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A202S,0.17
|
| 3 |
-
A25S,0.12
|
| 4 |
-
A70S,0.08
|
| 5 |
-
C112A,1.67
|
| 6 |
-
D119A,0.0
|
| 7 |
-
D128A,0.0
|
| 8 |
-
D135A,0.0
|
| 9 |
-
D169A,0.0
|
| 10 |
-
D169E,0.85
|
| 11 |
-
D50A,0.17
|
| 12 |
-
E116A,0.67
|
| 13 |
-
E130A,0.35
|
| 14 |
-
E142A,0.17
|
| 15 |
-
F171A,0.0
|
| 16 |
-
G117A,0.0
|
| 17 |
-
G134A,0.22
|
| 18 |
-
G140A,0.1
|
| 19 |
-
G189A,0.08
|
| 20 |
-
G55A,0.17
|
| 21 |
-
G59A,0.0
|
| 22 |
-
G91A,0.0
|
| 23 |
-
H180A,0.07
|
| 24 |
-
I118A,0.13
|
| 25 |
-
I204A,0.0
|
| 26 |
-
L138A,0.5
|
| 27 |
-
L196A,0.0
|
| 28 |
-
L197A,0.0
|
| 29 |
-
M1M,0.33
|
| 30 |
-
M60A,0.25
|
| 31 |
-
P184A,0.0
|
| 32 |
-
P193A,0.0
|
| 33 |
-
P53A,0.33
|
| 34 |
-
R114A,0.0
|
| 35 |
-
R121A,0.0
|
| 36 |
-
R154A,0.0
|
| 37 |
-
R208A,0.0
|
| 38 |
-
R215A,0.07
|
| 39 |
-
R219A,0.08
|
| 40 |
-
S132A,0.5
|
| 41 |
-
V192A,0.0
|
| 42 |
-
V195A,0.0
|
| 43 |
-
W131A,0.25
|
| 44 |
-
W207A,0.0
|
| 45 |
-
W207F,0.0
|
| 46 |
-
W207H,0.08
|
| 47 |
-
Y115A,0.03
|
| 48 |
-
Y136A,0.2
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A202S,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHSEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.17
|
| 3 |
+
A25S,MWIGIISLFPEMFRAITDYGVTGRSVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.12
|
| 4 |
+
A70S,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDSIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.08
|
| 5 |
+
C112A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVAGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,1.67
|
| 6 |
+
D119A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIAERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 7 |
+
D128A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIAEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 8 |
+
D135A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGAYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 9 |
+
D169A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEASFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 10 |
+
D169E,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEESFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.85
|
| 11 |
+
D50A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVADRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.17
|
| 12 |
+
E116A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYAGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.67
|
| 13 |
+
E130A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEAWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.35
|
| 14 |
+
E142A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGALPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.17
|
| 15 |
+
F171A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSAAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 16 |
+
G117A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEAIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 17 |
+
G134A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIADYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.22
|
| 18 |
+
G140A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSAGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.1
|
| 19 |
+
G189A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEAMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.08
|
| 20 |
+
G55A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYAGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.17
|
| 21 |
+
G59A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPAMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 22 |
+
G91A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQARKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 23 |
+
H180A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPAYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.07
|
| 24 |
+
I118A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGADERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.13
|
| 25 |
+
I204A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEARRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 26 |
+
L138A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVASGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.5
|
| 27 |
+
L196A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVALSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 28 |
+
L197A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLASGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 29 |
+
M1M,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.33
|
| 30 |
+
M60A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGALMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.25
|
| 31 |
+
P184A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRAEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 32 |
+
P193A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVAPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 33 |
+
P53A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRAYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.33
|
| 34 |
+
R114A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGAYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 35 |
+
R121A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDEAVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 36 |
+
R154A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSAFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 37 |
+
R208A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWALKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 38 |
+
R215A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGATWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.07
|
| 39 |
+
R219A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLARPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.08
|
| 40 |
+
S132A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWAIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.5
|
| 41 |
+
V192A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEAPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 42 |
+
V195A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPALLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 43 |
+
W131A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEASIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.25
|
| 44 |
+
W207A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRARLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 45 |
+
W207F,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRFRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.0
|
| 46 |
+
W207H,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRHRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.08
|
| 47 |
+
Y115A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRAEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.03
|
| 48 |
+
Y136A,MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDAVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA,0.2
|
mutant/activity/P27346_activity_PBO.csv
CHANGED
|
@@ -1,12 +1,12 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A145G,0.8137
|
| 3 |
-
A145G:P144A,0.015
|
| 4 |
-
A145G:P144A:V143A,2.125
|
| 5 |
-
A145G:S355A:V352A:K71A,2.8745
|
| 6 |
-
A145G:S355A:V352A:K71A:R187A,12.0945
|
| 7 |
-
A145G:S355A:V352A:K71A:R187A:T175A,25.6545
|
| 8 |
-
A145G:S355A:V352A:K71A:R187A:T175A:M92A,6.2954
|
| 9 |
-
A145G:S355C:V352A:K71A:R187A:T175A,58.71935
|
| 10 |
-
A145G:V143A,1.65
|
| 11 |
-
P144A,0.6273
|
| 12 |
-
V143A,2.1114
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A145G,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,0.8137
|
| 3 |
+
A145G:P144A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVAGPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,0.015
|
| 4 |
+
A145G:P144A:V143A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDAAGPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,2.125
|
| 5 |
+
A145G:S355A:V352A:K71A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGATVAYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,2.8745
|
| 6 |
+
A145G:S355A:V352A:K71A:R187A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGATAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGATVAYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,12.0945
|
| 7 |
+
A145G:S355A:V352A:K71A:R187A:T175A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVIAGKPVEFGGSLGATAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGATVAYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,25.6545
|
| 8 |
+
A145G:S355A:V352A:K71A:R187A:T175A:M92A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWATFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVIAGKPVEFGGSLGATAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGATVAYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,6.2954
|
| 9 |
+
A145G:S355C:V352A:K71A:R187A:T175A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVIAGKPVEFGGSLGATAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGATVCYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,58.71935
|
| 10 |
+
A145G:V143A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDAPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,1.65
|
| 11 |
+
P144A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVAAPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,0.6273
|
| 12 |
+
V143A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDAPAPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,2.1114
|
mutant/activity/P27346_activity_PTO.csv
CHANGED
|
@@ -1,11 +1,11 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A145G,5.9445
|
| 3 |
-
A145G:S355A:V352A:K71A,2.1334
|
| 4 |
-
A145G:S355A:V352A:K71A:R187A,4.6453
|
| 5 |
-
A145G:S355A:V352A:K71A:R187A:T175A,27.6452
|
| 6 |
-
A145G:S355A:V352A:K71A:R187A:T175A:M92A,0.2563
|
| 7 |
-
A145G:S355C:V352A:K71A:R187A:T175A,7.45045
|
| 8 |
-
K71A,175.2917
|
| 9 |
-
M1M,77.5314
|
| 10 |
-
P144A,127.8845
|
| 11 |
-
V143A,94.4521
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A145G,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,5.9445
|
| 3 |
+
A145G:S355A:V352A:K71A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGATVAYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,2.1334
|
| 4 |
+
A145G:S355A:V352A:K71A:R187A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGATAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGATVAYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,4.6453
|
| 5 |
+
A145G:S355A:V352A:K71A:R187A:T175A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVIAGKPVEFGGSLGATAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGATVAYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,27.6452
|
| 6 |
+
A145G:S355A:V352A:K71A:R187A:T175A:M92A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWATFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVIAGKPVEFGGSLGATAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGATVAYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,0.2563
|
| 7 |
+
A145G:S355C:V352A:K71A:R187A:T175A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVIAGKPVEFGGSLGATAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGATVCYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,7.45045
|
| 8 |
+
K71A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPAPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,175.2917
|
| 9 |
+
M1M,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPAPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,77.5314
|
| 10 |
+
P144A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVAAPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,127.8845
|
| 11 |
+
V143A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDAPAPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,94.4521
|
mutant/activity/P27346_activity_aKG.csv
CHANGED
|
@@ -1,11 +1,11 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A145G,734.2523
|
| 3 |
-
A145G:S355A:V352A:K71A,0.2401
|
| 4 |
-
A145G:S355A:V352A:K71A:R187A,0.8142
|
| 5 |
-
A145G:S355A:V352A:K71A:R187A:T175A,0.7751
|
| 6 |
-
A145G:S355A:V352A:K71A:R187A:T175A:M92A,0.81
|
| 7 |
-
A145G:S355C:V352A:K71A:R187A:T175A,0.31085
|
| 8 |
-
K71A,52.277
|
| 9 |
-
M1M,2338.2818
|
| 10 |
-
P144A,2966.1598
|
| 11 |
-
V143A,743.2321
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A145G,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,734.2523
|
| 3 |
+
A145G:S355A:V352A:K71A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGATVAYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,0.2401
|
| 4 |
+
A145G:S355A:V352A:K71A:R187A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGATAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGATVAYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,0.8142
|
| 5 |
+
A145G:S355A:V352A:K71A:R187A:T175A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVIAGKPVEFGGSLGATAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGATVAYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,0.7751
|
| 6 |
+
A145G:S355A:V352A:K71A:R187A:T175A:M92A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWATFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVIAGKPVEFGGSLGATAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGATVAYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,0.81
|
| 7 |
+
A145G:S355C:V352A:K71A:R187A:T175A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPGPDVNTNGQIMSWMVDEYNKLTGQSSIGVIAGKPVEFGGSLGATAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGATVCYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,0.31085
|
| 8 |
+
K71A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTAGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPAPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,52.277
|
| 9 |
+
M1M,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVPAPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,2338.2818
|
| 10 |
+
P144A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDVAAPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,2966.1598
|
| 11 |
+
V143A,MSGKDVNVFEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVGPTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRGYIDGIYKLIGEKVDAPAPDVNTNGQIMSWMVDEYNKLTGQSSIGVITGKPVEFGGSLGRTAATGFGVAVTAREAAAKLGIDMKKAKIAVQGIGNVGSYTVLNCEKLGGTVVAMAEWCKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENSITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLYGYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGWY,743.2321
|
mutant/activity/Q51559_activity.csv
CHANGED
|
@@ -1,113 +1,113 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A128G,63.0
|
| 3 |
-
A128I,5.0
|
| 4 |
-
A128L,7.0
|
| 5 |
-
A128S,57.0
|
| 6 |
-
A128V,55.0
|
| 7 |
-
A128W,0.0
|
| 8 |
-
A142P,2.0
|
| 9 |
-
A142P:A144P,2.0
|
| 10 |
-
A144D,78.0
|
| 11 |
-
A153H,24.0
|
| 12 |
-
A179T,73.0
|
| 13 |
-
A182P,39.0
|
| 14 |
-
A189P,1.0
|
| 15 |
-
A198E,105.0
|
| 16 |
-
A198P,10.0
|
| 17 |
-
A36G,2.0
|
| 18 |
-
A36I,7.0
|
| 19 |
-
A36L,6.0
|
| 20 |
-
A36M,43.0
|
| 21 |
-
A36V,13.0
|
| 22 |
-
D137A,32.0
|
| 23 |
-
D137E,51.0
|
| 24 |
-
D149G,86.0
|
| 25 |
-
D194N,63.0
|
| 26 |
-
D223A,0.0
|
| 27 |
-
D230E,148.0
|
| 28 |
-
E147A,85.0
|
| 29 |
-
E160A,2.0
|
| 30 |
-
E160D,80.0
|
| 31 |
-
E185A,12.0
|
| 32 |
-
E187D,0.0
|
| 33 |
-
E224A,99.0
|
| 34 |
-
E224D,134.0
|
| 35 |
-
E256D,0.0
|
| 36 |
-
G184D,84.0
|
| 37 |
-
H156Q,66.0
|
| 38 |
-
H177Y,0.0
|
| 39 |
-
H192A,9.0
|
| 40 |
-
H192K,5.0
|
| 41 |
-
H192R,1.0
|
| 42 |
-
H251A,0.0
|
| 43 |
-
K151N,8.0
|
| 44 |
-
K164A,55.0
|
| 45 |
-
K164R,156.0
|
| 46 |
-
K164R:T227S,60.0
|
| 47 |
-
K164R:Y165F,59.0
|
| 48 |
-
K79Q,6.0
|
| 49 |
-
K79R,9.0
|
| 50 |
-
L131A,21.0
|
| 51 |
-
L131I,86.0
|
| 52 |
-
L131V,0.0
|
| 53 |
-
L145A,27.0
|
| 54 |
-
L145H,60.0
|
| 55 |
-
L145I,23.0
|
| 56 |
-
L148A,106.0
|
| 57 |
-
L148I,86.0
|
| 58 |
-
L157A,5.0
|
| 59 |
-
L157I,18.0
|
| 60 |
-
L157P,2.0
|
| 61 |
-
L158A,3.0
|
| 62 |
-
L158I,101.0
|
| 63 |
-
L158P,2.0
|
| 64 |
-
L199A,0.0
|
| 65 |
-
L199I,54.0
|
| 66 |
-
L199M,4.0
|
| 67 |
-
L199V,29.0
|
| 68 |
-
M1M,100.0
|
| 69 |
-
M37A,0.0
|
| 70 |
-
M37F,12.0
|
| 71 |
-
M37I,9.0
|
| 72 |
-
M37L,123.0
|
| 73 |
-
M37V,43.0
|
| 74 |
-
N132K,3.0
|
| 75 |
-
N132Q,11.0
|
| 76 |
-
N132R,15.0
|
| 77 |
-
Q188N,29.0
|
| 78 |
-
Q66R,68.0
|
| 79 |
-
Q69K,8.0
|
| 80 |
-
Q69N,138.0
|
| 81 |
-
Q69R,0.0
|
| 82 |
-
R141A,63.0
|
| 83 |
-
R141A:T161A:K164R,0.0
|
| 84 |
-
R141K,121.0
|
| 85 |
-
R141K:K164R,97.0
|
| 86 |
-
R169I,16.0
|
| 87 |
-
R169K,126.0
|
| 88 |
-
R190A,0.0
|
| 89 |
-
R202D,0.0
|
| 90 |
-
R202E,0.0
|
| 91 |
-
R202K,201.0
|
| 92 |
-
S102A,0.0
|
| 93 |
-
S152L,29.0
|
| 94 |
-
S173Y,10.0
|
| 95 |
-
T161A,57.0
|
| 96 |
-
T161S,23.0
|
| 97 |
-
T183R,0.0
|
| 98 |
-
T227D,38.0
|
| 99 |
-
T227E,31.0
|
| 100 |
-
T227S,145.0
|
| 101 |
-
W103A,11.0
|
| 102 |
-
W103Y,9.0
|
| 103 |
-
Y138A,12.0
|
| 104 |
-
Y138F,14.0
|
| 105 |
-
Y165A,4.0
|
| 106 |
-
Y165F,187.0
|
| 107 |
-
Y165F:T227S,13.0
|
| 108 |
-
Y186Q,0.0
|
| 109 |
-
Y204D,88.0
|
| 110 |
-
Y204E,93.0
|
| 111 |
-
Y225A,0.0
|
| 112 |
-
Y225F,14.0
|
| 113 |
-
Y225S,6.0
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A128G,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFGPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,63.0
|
| 3 |
+
A128I,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFIPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,5.0
|
| 4 |
+
A128L,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFLPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,7.0
|
| 5 |
+
A128S,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFSPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,57.0
|
| 6 |
+
A128V,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFVPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,55.0
|
| 7 |
+
A128W,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFWPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 8 |
+
A142P,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRPQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,2.0
|
| 9 |
+
A142P:A144P,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRPQPLIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,2.0
|
| 10 |
+
A144D,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQDLIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,78.0
|
| 11 |
+
A153H,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSHIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,24.0
|
| 12 |
+
A179T,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMTSLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,73.0
|
| 13 |
+
A182P,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLPTGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,39.0
|
| 14 |
+
A189P,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQPRFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,1.0
|
| 15 |
+
A198E,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLELNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,105.0
|
| 16 |
+
A198P,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLPLNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,10.0
|
| 17 |
+
A36G,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGGMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,2.0
|
| 18 |
+
A36I,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGIMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,7.0
|
| 19 |
+
A36L,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGLMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,6.0
|
| 20 |
+
A36M,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGMMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,43.0
|
| 21 |
+
A36V,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGVMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,13.0
|
| 22 |
+
D137A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLAYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,32.0
|
| 23 |
+
D137E,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLEYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,51.0
|
| 24 |
+
D149G,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELGDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,86.0
|
| 25 |
+
D194N,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHINQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,63.0
|
| 26 |
+
D223A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWAEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 27 |
+
D230E,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEEARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,148.0
|
| 28 |
+
E147A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIALDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,85.0
|
| 29 |
+
E160A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNATVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,2.0
|
| 30 |
+
E160D,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNDTVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,80.0
|
| 31 |
+
E185A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGAYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,12.0
|
| 32 |
+
E187D,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYDQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 33 |
+
E224A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDAYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,99.0
|
| 34 |
+
E224D,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDDYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,134.0
|
| 35 |
+
E256D,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLDSKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 36 |
+
G184D,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATDEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,84.0
|
| 37 |
+
H156Q,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGQLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,66.0
|
| 38 |
+
H177Y,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQYMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 39 |
+
H192A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFAIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,9.0
|
| 40 |
+
H192K,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFKIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,5.0
|
| 41 |
+
H192R,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFRIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,1.0
|
| 42 |
+
H251A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGAFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 43 |
+
K151N,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDNSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,8.0
|
| 44 |
+
K164A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGAYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,55.0
|
| 45 |
+
K164R,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGRYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,156.0
|
| 46 |
+
K164R:T227S,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGRYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTSAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,60.0
|
| 47 |
+
K164R:Y165F,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGRFLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,59.0
|
| 48 |
+
K79Q,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITQDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,6.0
|
| 49 |
+
K79R,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITRDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,9.0
|
| 50 |
+
L131A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGANQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,21.0
|
| 51 |
+
L131I,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGINQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,86.0
|
| 52 |
+
L131V,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGVNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 53 |
+
L145A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQAAIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,27.0
|
| 54 |
+
L145H,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQAHIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,60.0
|
| 55 |
+
L145I,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQAIIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,23.0
|
| 56 |
+
L148A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIEADDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,106.0
|
| 57 |
+
L148I,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIEIDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,86.0
|
| 58 |
+
L157A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHALNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,5.0
|
| 59 |
+
L157I,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHILNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,18.0
|
| 60 |
+
L157P,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHPLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,2.0
|
| 61 |
+
L158A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLANETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,3.0
|
| 62 |
+
L158I,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLINETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,101.0
|
| 63 |
+
L158P,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLPNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,2.0
|
| 64 |
+
L199A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLAANDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 65 |
+
L199I,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLAINDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,54.0
|
| 66 |
+
L199M,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLAMNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,4.0
|
| 67 |
+
L199V,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLAVNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,29.0
|
| 68 |
+
M1M,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,100.0
|
| 69 |
+
M37A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAAATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 70 |
+
M37F,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAFATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,12.0
|
| 71 |
+
M37I,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAIATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,9.0
|
| 72 |
+
M37L,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGALATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,123.0
|
| 73 |
+
M37V,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAVATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,43.0
|
| 74 |
+
N132K,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLKQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,3.0
|
| 75 |
+
N132Q,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLQQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,11.0
|
| 76 |
+
N132R,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLRQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,15.0
|
| 77 |
+
Q188N,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYENARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,29.0
|
| 78 |
+
Q66R,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGRSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,68.0
|
| 79 |
+
Q69K,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRKHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,8.0
|
| 80 |
+
Q69N,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRNHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,138.0
|
| 81 |
+
Q69R,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRRHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 82 |
+
R141A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGAAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,63.0
|
| 83 |
+
R141A:T161A:K164R,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGAAQALIELDDKSAIGHLLNEAVGRYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 84 |
+
R141K,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGKAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,121.0
|
| 85 |
+
R141K:K164R,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGKAQALIELDDKSAIGHLLNETVGRYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,97.0
|
| 86 |
+
R169I,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQILKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,16.0
|
| 87 |
+
R169K,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQKLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,126.0
|
| 88 |
+
R190A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQAAFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 89 |
+
R202D,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDDGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 90 |
+
R202E,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDEGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 91 |
+
R202K,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDKGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,201.0
|
| 92 |
+
S102A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSAAWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 93 |
+
S152L,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKLAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,29.0
|
| 94 |
+
S173Y,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKAYNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,10.0
|
| 95 |
+
T161A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNEAVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,57.0
|
| 96 |
+
T161S,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNESVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,23.0
|
| 97 |
+
T183R,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLARGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 98 |
+
T227D,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTDAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,38.0
|
| 99 |
+
T227E,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTEAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,31.0
|
| 100 |
+
T227S,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTSAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,145.0
|
| 101 |
+
W103A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASAGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,11.0
|
| 102 |
+
W103Y,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASYGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,9.0
|
| 103 |
+
Y138A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDAVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,12.0
|
| 104 |
+
Y138F,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDFVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,14.0
|
| 105 |
+
Y165A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKALPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,4.0
|
| 106 |
+
Y165F,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKFLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,187.0
|
| 107 |
+
Y165F:T227S,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKFLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTSAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,13.0
|
| 108 |
+
Y186Q,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEQEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 109 |
+
Y204D,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGDLACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,88.0
|
| 110 |
+
Y204E,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGELACLERIQSHVHFINGSWDEYTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,93.0
|
| 111 |
+
Y225A,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEATTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,0.0
|
| 112 |
+
Y225F,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDEFTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,14.0
|
| 113 |
+
Y225S,MRRESLLVSVCKGLRVHVERVGQDPGRSTVMLVNGAMATTASFARTCKCLAEHFNVVLFDLPFAGQSRQHNPQRGLITKDDEVEILLALIERFEVNHLVSASWGGISTLLALSRNPRGIRSSVVMAFAPGLNQAMLDYVGRAQALIELDDKSAIGHLLNETVGKYLPQRLKASNHQHMASLATGEYEQARFHIDQVLALNDRGYLACLERIQSHVHFINGSWDESTTAEDARQFRDYLPHCSFSRVEGTGHFLDLESKLAAVRVHRALLEHLLKQPEPQRAERAAGFHEMAIGYA,6.0
|
mutant/dti_binding/BindingDB_P41145_214799_Ki.csv
CHANGED
|
@@ -15,7 +15,7 @@ L212A,MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGL
|
|
| 15 |
M226A,MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFAKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV,-2.255272505103306
|
| 16 |
K227A,MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMAICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV,-1.7075701760979365
|
| 17 |
H291A,MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIAIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV,-2.591064607026499
|
| 18 |
-
H291F,MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIFIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV,-1.
|
| 19 |
I294A,MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFALVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV,-2.681241237375587
|
| 20 |
E297A,MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVAALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV,-2.041392685158225
|
| 21 |
Y312A,MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSAYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV,-2.591064607026499
|
|
|
|
| 15 |
M226A,MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFAKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV,-2.255272505103306
|
| 16 |
K227A,MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMAICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV,-1.7075701760979365
|
| 17 |
H291A,MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIAIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV,-2.591064607026499
|
| 18 |
+
H291F,MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIFIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV,-1.812913356642856
|
| 19 |
I294A,MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFALVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV,-2.681241237375587
|
| 20 |
E297A,MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVAALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV,-2.041392685158225
|
| 21 |
Y312A,MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSAYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV,-2.591064607026499
|
mutant/dti_binding/BindingDB_Q873X9_10854_Kd.csv
CHANGED
|
@@ -1,6 +1,6 @@
|
|
| 1 |
mutant,mutated_sequence,fitness_score
|
| 2 |
M1M,MRFATSTIVKVALLLSSLCVDAAVMWNRDTSSTDLEARASSGYRSVVYFVNWAIYGRNHNPQDLPVERLTHVLYAFANVRPETGEVYMTDSWADIEKHYPGDSWSDTGNNVYGCIKQLYLLKKQNRNLKVLLSIGGWTYSPNFAPAASTDAGRKNFAKTAVKLLQDLGFDGLDIDWEYPENDQQANDFVLLLKEVRTALDSYSAANAGGQHFLLTVASPAGPDKIKVLHLKDMDQQLDFWNLMAYDYAGSFSSLSGHQANVYNDTSNPLSTPFNTQTALDLYRAGGVPANKIVLGMPLYGRSFANTDGPGKPYNGVGQGSWENGVWDYKALPQAGATEHVLPDIMASYSYDATNKFLISYDNPQVANLKSGYIKSLGLGGAMWWDSSSDKTGSDSLITTVVNALGGTGVFEQSQNELDYPVSQYDNLRNGMQT,-2.908485018878649
|
| 3 |
-
D175A,MRFATSTIVKVALLLSSLCVDAAVMWNRDTSSTDLEARASSGYRSVVYFVNWAIYGRNHNPQDLPVERLTHVLYAFANVRPETGEVYMTDSWADIEKHYPGDSWSDTGNNVYGCIKQLYLLKKQNRNLKVLLSIGGWTYSPNFAPAASTDAGRKNFAKTAVKLLQDLGFDGLDIAWEYPENDQQANDFVLLLKEVRTALDSYSAANAGGQHFLLTVASPAGPDKIKVLHLKDMDQQLDFWNLMAYDYAGSFSSLSGHQANVYNDTSNPLSTPFNTQTALDLYRAGGVPANKIVLGMPLYGRSFANTDGPGKPYNGVGQGSWENGVWDYKALPQAGATEHVLPDIMASYSYDATNKFLISYDNPQVANLKSGYIKSLGLGGAMWWDSSSDKTGSDSLITTVVNALGGTGVFEQSQNELDYPVSQYDNLRNGMQT,-3.
|
| 4 |
Y245F,MRFATSTIVKVALLLSSLCVDAAVMWNRDTSSTDLEARASSGYRSVVYFVNWAIYGRNHNPQDLPVERLTHVLYAFANVRPETGEVYMTDSWADIEKHYPGDSWSDTGNNVYGCIKQLYLLKKQNRNLKVLLSIGGWTYSPNFAPAASTDAGRKNFAKTAVKLLQDLGFDGLDIDWEYPENDQQANDFVLLLKEVRTALDSYSAANAGGQHFLLTVASPAGPDKIKVLHLKDMDQQLDFWNLMAFDYAGSFSSLSGHQANVYNDTSNPLSTPFNTQTALDLYRAGGVPANKIVLGMPLYGRSFANTDGPGKPYNGVGQGSWENGVWDYKALPQAGATEHVLPDIMASYSYDATNKFLISYDNPQVANLKSGYIKSLGLGGAMWWDSSSDKTGSDSLITTVVNALGGTGVFEQSQNELDYPVSQYDNLRNGMQT,-3.745855195173729
|
| 5 |
R301K,MRFATSTIVKVALLLSSLCVDAAVMWNRDTSSTDLEARASSGYRSVVYFVNWAIYGRNHNPQDLPVERLTHVLYAFANVRPETGEVYMTDSWADIEKHYPGDSWSDTGNNVYGCIKQLYLLKKQNRNLKVLLSIGGWTYSPNFAPAASTDAGRKNFAKTAVKLLQDLGFDGLDIDWEYPENDQQANDFVLLLKEVRTALDSYSAANAGGQHFLLTVASPAGPDKIKVLHLKDMDQQLDFWNLMAYDYAGSFSSLSGHQANVYNDTSNPLSTPFNTQTALDLYRAGGVPANKIVLGMPLYGKSFANTDGPGKPYNGVGQGSWENGVWDYKALPQAGATEHVLPDIMASYSYDATNKFLISYDNPQVANLKSGYIKSLGLGGAMWWDSSSDKTGSDSLITTVVNALGGTGVFEQSQNELDYPVSQYDNLRNGMQT,-3.008600171761917
|
| 6 |
A217G,MRFATSTIVKVALLLSSLCVDAAVMWNRDTSSTDLEARASSGYRSVVYFVNWAIYGRNHNPQDLPVERLTHVLYAFANVRPETGEVYMTDSWADIEKHYPGDSWSDTGNNVYGCIKQLYLLKKQNRNLKVLLSIGGWTYSPNFAPAASTDAGRKNFAKTAVKLLQDLGFDGLDIDWEYPENDQQANDFVLLLKEVRTALDSYSAANAGGQHFLLTVGSPAGPDKIKVLHLKDMDQQLDFWNLMAYDYAGSFSSLSGHQANVYNDTSNPLSTPFNTQTALDLYRAGGVPANKIVLGMPLYGRSFANTDGPGKPYNGVGQGSWENGVWDYKALPQAGATEHVLPDIMASYSYDATNKFLISYDNPQVANLKSGYIKSLGLGGAMWWDSSSDKTGSDSLITTVVNALGGTGVFEQSQNELDYPVSQYDNLRNGMQT,-3.453318340047037
|
|
|
|
| 1 |
mutant,mutated_sequence,fitness_score
|
| 2 |
M1M,MRFATSTIVKVALLLSSLCVDAAVMWNRDTSSTDLEARASSGYRSVVYFVNWAIYGRNHNPQDLPVERLTHVLYAFANVRPETGEVYMTDSWADIEKHYPGDSWSDTGNNVYGCIKQLYLLKKQNRNLKVLLSIGGWTYSPNFAPAASTDAGRKNFAKTAVKLLQDLGFDGLDIDWEYPENDQQANDFVLLLKEVRTALDSYSAANAGGQHFLLTVASPAGPDKIKVLHLKDMDQQLDFWNLMAYDYAGSFSSLSGHQANVYNDTSNPLSTPFNTQTALDLYRAGGVPANKIVLGMPLYGRSFANTDGPGKPYNGVGQGSWENGVWDYKALPQAGATEHVLPDIMASYSYDATNKFLISYDNPQVANLKSGYIKSLGLGGAMWWDSSSDKTGSDSLITTVVNALGGTGVFEQSQNELDYPVSQYDNLRNGMQT,-2.908485018878649
|
| 3 |
+
D175A,MRFATSTIVKVALLLSSLCVDAAVMWNRDTSSTDLEARASSGYRSVVYFVNWAIYGRNHNPQDLPVERLTHVLYAFANVRPETGEVYMTDSWADIEKHYPGDSWSDTGNNVYGCIKQLYLLKKQNRNLKVLLSIGGWTYSPNFAPAASTDAGRKNFAKTAVKLLQDLGFDGLDIAWEYPENDQQANDFVLLLKEVRTALDSYSAANAGGQHFLLTVASPAGPDKIKVLHLKDMDQQLDFWNLMAYDYAGSFSSLSGHQANVYNDTSNPLSTPFNTQTALDLYRAGGVPANKIVLGMPLYGRSFANTDGPGKPYNGVGQGSWENGVWDYKALPQAGATEHVLPDIMASYSYDATNKFLISYDNPQVANLKSGYIKSLGLGGAMWWDSSSDKTGSDSLITTVVNALGGTGVFEQSQNELDYPVSQYDNLRNGMQT,-3.556302500767288
|
| 4 |
Y245F,MRFATSTIVKVALLLSSLCVDAAVMWNRDTSSTDLEARASSGYRSVVYFVNWAIYGRNHNPQDLPVERLTHVLYAFANVRPETGEVYMTDSWADIEKHYPGDSWSDTGNNVYGCIKQLYLLKKQNRNLKVLLSIGGWTYSPNFAPAASTDAGRKNFAKTAVKLLQDLGFDGLDIDWEYPENDQQANDFVLLLKEVRTALDSYSAANAGGQHFLLTVASPAGPDKIKVLHLKDMDQQLDFWNLMAFDYAGSFSSLSGHQANVYNDTSNPLSTPFNTQTALDLYRAGGVPANKIVLGMPLYGRSFANTDGPGKPYNGVGQGSWENGVWDYKALPQAGATEHVLPDIMASYSYDATNKFLISYDNPQVANLKSGYIKSLGLGGAMWWDSSSDKTGSDSLITTVVNALGGTGVFEQSQNELDYPVSQYDNLRNGMQT,-3.745855195173729
|
| 5 |
R301K,MRFATSTIVKVALLLSSLCVDAAVMWNRDTSSTDLEARASSGYRSVVYFVNWAIYGRNHNPQDLPVERLTHVLYAFANVRPETGEVYMTDSWADIEKHYPGDSWSDTGNNVYGCIKQLYLLKKQNRNLKVLLSIGGWTYSPNFAPAASTDAGRKNFAKTAVKLLQDLGFDGLDIDWEYPENDQQANDFVLLLKEVRTALDSYSAANAGGQHFLLTVASPAGPDKIKVLHLKDMDQQLDFWNLMAYDYAGSFSSLSGHQANVYNDTSNPLSTPFNTQTALDLYRAGGVPANKIVLGMPLYGKSFANTDGPGKPYNGVGQGSWENGVWDYKALPQAGATEHVLPDIMASYSYDATNKFLISYDNPQVANLKSGYIKSLGLGGAMWWDSSSDKTGSDSLITTVVNALGGTGVFEQSQNELDYPVSQYDNLRNGMQT,-3.008600171761917
|
| 6 |
A217G,MRFATSTIVKVALLLSSLCVDAAVMWNRDTSSTDLEARASSGYRSVVYFVNWAIYGRNHNPQDLPVERLTHVLYAFANVRPETGEVYMTDSWADIEKHYPGDSWSDTGNNVYGCIKQLYLLKKQNRNLKVLLSIGGWTYSPNFAPAASTDAGRKNFAKTAVKLLQDLGFDGLDIDWEYPENDQQANDFVLLLKEVRTALDSYSAANAGGQHFLLTVGSPAGPDKIKVLHLKDMDQQLDFWNLMAYDYAGSFSSLSGHQANVYNDTSNPLSTPFNTQTALDLYRAGGVPANKIVLGMPLYGRSFANTDGPGKPYNGVGQGSWENGVWDYKALPQAGATEHVLPDIMASYSYDATNKFLISYDNPQVANLKSGYIKSLGLGGAMWWDSSSDKTGSDSLITTVVNALGGTGVFEQSQNELDYPVSQYDNLRNGMQT,-3.453318340047037
|
mutant/ppi_binding/PPB_Affinity_1AO7_D_kd.csv
CHANGED
|
@@ -33,4 +33,4 @@ T92A,KEVEQNSGPLSVPEGAIASLNCTYSDRGSQSFFWYRQYSGKSPELIMSIYSNGDKEDGRFTAQLNKASQYVSLLI
|
|
| 33 |
S94Y,KEVEQNSGPLSVPEGAIASLNCTYSDRGSQSFFWYRQYSGKSPELIMSIYSNGDKEDGRFTAQLNKASQYVSLLIRDSQPSDSATYLCAVTTDYWGKLQFGAGTQVVVTPDIQNP,3.9788107009300617
|
| 34 |
G28R,KEVEQNSGPLSVPEGAIASLNCTYSDRRSQSFFWYRQYSGKSPELIMSIYSNGDKEDGRFTAQLNKASQYVSLLIRDSQPSDSATYLCAVTTDSWGKLQFGAGTQVVVTPDIQNP,3.977777895492294
|
| 35 |
D93N,KEVEQNSGPLSVPEGAIASLNCTYSDRGSQSFFWYRQYSGKSPELIMSIYSNGDKEDGRFTAQLNKASQYVSLLIRDSQPSDSATYLCAVTTNSWGKLQFGAGTQVVVTPDIQNP,3.8096683018297086
|
| 36 |
-
W95A,KEVEQNSGPLSVPEGAIASLNCTYSDRGSQSFFWYRQYSGKSPELIMSIYSNGDKEDGRFTAQLNKASQYVSLLIRDSQPSDSATYLCAVTTDSAGKLQFGAGTQVVVTPDIQNP,3.
|
|
|
|
| 33 |
S94Y,KEVEQNSGPLSVPEGAIASLNCTYSDRGSQSFFWYRQYSGKSPELIMSIYSNGDKEDGRFTAQLNKASQYVSLLIRDSQPSDSATYLCAVTTDYWGKLQFGAGTQVVVTPDIQNP,3.9788107009300617
|
| 34 |
G28R,KEVEQNSGPLSVPEGAIASLNCTYSDRRSQSFFWYRQYSGKSPELIMSIYSNGDKEDGRFTAQLNKASQYVSLLIRDSQPSDSATYLCAVTTDSWGKLQFGAGTQVVVTPDIQNP,3.977777895492294
|
| 35 |
D93N,KEVEQNSGPLSVPEGAIASLNCTYSDRGSQSFFWYRQYSGKSPELIMSIYSNGDKEDGRFTAQLNKASQYVSLLIRDSQPSDSATYLCAVTTNSWGKLQFGAGTQVVVTPDIQNP,3.8096683018297086
|
| 36 |
+
W95A,KEVEQNSGPLSVPEGAIASLNCTYSDRGSQSFFWYRQYSGKSPELIMSIYSNGDKEDGRFTAQLNKASQYVSLLIRDSQPSDSATYLCAVTTDSAGKLQFGAGTQVVVTPDIQNP,3.747146969020106
|
mutant/ppi_binding/PPB_Affinity_1MI5_D_kd.csv
CHANGED
|
@@ -22,4 +22,4 @@ L49A,KTTQPNSMESNEEEPVHLPCNHSTISGTDYIHWYRQLPSQGPEYVIHGATSNVNNRMASLAIAEDRKSSTLILHR
|
|
| 22 |
H32A,KTTQPNSMESNEEEPVHLPCNHSTISGTDYIAWYRQLPSQGPEYVIHGLTSNVNNRMASLAIAEDRKSSTLILHRATLRDAAVYYCILPLAGGTSYGKLTFGQGTILTVHPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPS,4.0
|
| 23 |
D29A,KTTQPNSMESNEEEPVHLPCNHSTISGTAYIHWYRQLPSQGPEYVIHGLTSNVNNRMASLAIAEDRKSSTLILHRATLRDAAVYYCILPLAGGTSYGKLTFGQGTILTVHPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPS,4.0
|
| 24 |
G97A,KTTQPNSMESNEEEPVHLPCNHSTISGTDYIHWYRQLPSQGPEYVIHGLTSNVNNRMASLAIAEDRKSSTLILHRATLRDAAVYYCILPLAGGTSYAKLTFGQGTILTVHPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPS,3.823908740944319
|
| 25 |
-
G102A,KTTQPNSMESNEEEPVHLPCNHSTISGTDYIHWYRQLPSQGPEYVIHGLTSNVNNRMASLAIAEDRKSSTLILHRATLRDAAVYYCILPLAGGTSYGKLTFAQGTILTVHPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPS,3.
|
|
|
|
| 22 |
H32A,KTTQPNSMESNEEEPVHLPCNHSTISGTDYIAWYRQLPSQGPEYVIHGLTSNVNNRMASLAIAEDRKSSTLILHRATLRDAAVYYCILPLAGGTSYGKLTFGQGTILTVHPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPS,4.0
|
| 23 |
D29A,KTTQPNSMESNEEEPVHLPCNHSTISGTAYIHWYRQLPSQGPEYVIHGLTSNVNNRMASLAIAEDRKSSTLILHRATLRDAAVYYCILPLAGGTSYGKLTFGQGTILTVHPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPS,4.0
|
| 24 |
G97A,KTTQPNSMESNEEEPVHLPCNHSTISGTDYIHWYRQLPSQGPEYVIHGLTSNVNNRMASLAIAEDRKSSTLILHRATLRDAAVYYCILPLAGGTSYAKLTFGQGTILTVHPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPS,3.823908740944319
|
| 25 |
+
G102A,KTTQPNSMESNEEEPVHLPCNHSTISGTDYIHWYRQLPSQGPEYVIHGLTSNVNNRMASLAIAEDRKSSTLILHRATLRDAAVYYCILPLAGGTSYGKLTFAQGTILTVHPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPS,3.6989700043360174
|
mutant/ppi_binding/PPB_Affinity_1OGA_E_kd.csv
CHANGED
|
@@ -10,11 +10,11 @@ Q54A,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIVNDFAKGDIAEGYSVSREKKESFPLT
|
|
| 10 |
N51A,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIVADFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,4.455931955649724
|
| 11 |
I49L,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQLVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,4.2441251443275085
|
| 12 |
D28A,GITQSPKYLFRKEGQNVTLSCEQNLNHAAMYWYRQDPGQGLRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,4.130768280269024
|
| 13 |
-
D28S,GITQSPKYLFRKEGQNVTLSCEQNLNHSAMYWYRQDPGQGLRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,3.
|
| 14 |
-
I49N,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQNVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,3.
|
| 15 |
-
I49G,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQGVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,3.
|
| 16 |
-
I49A,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQAVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,3.
|
| 17 |
-
R94A,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSASSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,3.
|
| 18 |
-
R94H,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSHSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,3.
|
| 19 |
-
Q48E,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSEIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,3.
|
| 20 |
-
Q48A,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSAIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,3.
|
|
|
|
| 10 |
N51A,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIVADFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,4.455931955649724
|
| 11 |
I49L,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQLVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,4.2441251443275085
|
| 12 |
D28A,GITQSPKYLFRKEGQNVTLSCEQNLNHAAMYWYRQDPGQGLRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,4.130768280269024
|
| 13 |
+
D28S,GITQSPKYLFRKEGQNVTLSCEQNLNHSAMYWYRQDPGQGLRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,3.6989700043360174
|
| 14 |
+
I49N,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQNVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,3.6989700043360174
|
| 15 |
+
I49G,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQGVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,3.6989700043360174
|
| 16 |
+
I49A,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQAVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,3.6989700043360174
|
| 17 |
+
R94A,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSASSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,3.6989700043360174
|
| 18 |
+
R94H,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSHSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,3.6989700043360174
|
| 19 |
+
Q48E,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSEIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,3.6989700043360174
|
| 20 |
+
Q48A,GITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSAIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADQ,3.6989700043360174
|
mutant/selectivity/ACCO_ee.csv
CHANGED
|
@@ -1,11 +1,11 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
I184A,-0.76
|
| 3 |
-
I184A:K158I,0.48
|
| 4 |
-
I184A:K158I:F91L,0.68
|
| 5 |
-
I184A:K158I:F91L:K172Y,0.76
|
| 6 |
-
I184A:K158I:F91L:K172Y:K93Q,0.84
|
| 7 |
-
I184A:K158I:F91L:K172Y:K93Q:T89A,0.9
|
| 8 |
-
I184A:K158N,-0.62
|
| 9 |
-
I184A:K158N:F250Y,-0.74
|
| 10 |
-
I184A:K158N:F250Y:F91E,-0.74
|
| 11 |
-
M1M,-0.8
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
I184A,MENFPIISLDKVNGVERAATMEMIKDACENWGFFELVNHGIPREVMDTVEKMTKGHYKKCMEQRFKELVASKALEGVQAEVTDMDWESTFFLKHLPISNISEVPDLDEEYREVMRDFAKRLEKLAEELLDLLCENLGLEKGYLKNAFYGSKGPNFGTKVSNYPPCPKPDLIKGLRAHTDAGGIALLFQDDKVSGLQLLKDGQWIDVPPMRHSIVVNLGDQLEVITNGKYKSVMHRVIAQKDGARMSLASFYNPGSDAVIYPAPALVEKEAEENKQVYPKFVFDDYMKLYAGLKFQAKEPRFEAMKAMETDVKMDPIATV,-0.76
|
| 3 |
+
I184A:K158I,MENFPIISLDKVNGVERAATMEMIKDACENWGFFELVNHGIPREVMDTVEKMTKGHYKKCMEQRFKELVASKALEGVQAEVTDMDWESTFFLKHLPISNISEVPDLDEEYREVMRDFAKRLEKLAEELLDLLCENLGLEKGYLKNAFYGSKGPNFGTIVSNYPPCPKPDLIKGLRAHTDAGGIALLFQDDKVSGLQLLKDGQWIDVPPMRHSIVVNLGDQLEVITNGKYKSVMHRVIAQKDGARMSLASFYNPGSDAVIYPAPALVEKEAEENKQVYPKFVFDDYMKLYAGLKFQAKEPRFEAMKAMETDVKMDPIATV,0.48
|
| 4 |
+
I184A:K158I:F91L,MENFPIISLDKVNGVERAATMEMIKDACENWGFFELVNHGIPREVMDTVEKMTKGHYKKCMEQRFKELVASKALEGVQAEVTDMDWESTFLLKHLPISNISEVPDLDEEYREVMRDFAKRLEKLAEELLDLLCENLGLEKGYLKNAFYGSKGPNFGTIVSNYPPCPKPDLIKGLRAHTDAGGIALLFQDDKVSGLQLLKDGQWIDVPPMRHSIVVNLGDQLEVITNGKYKSVMHRVIAQKDGARMSLASFYNPGSDAVIYPAPALVEKEAEENKQVYPKFVFDDYMKLYAGLKFQAKEPRFEAMKAMETDVKMDPIATV,0.68
|
| 5 |
+
I184A:K158I:F91L:K172Y,MENFPIISLDKVNGVERAATMEMIKDACENWGFFELVNHGIPREVMDTVEKMTKGHYKKCMEQRFKELVASKALEGVQAEVTDMDWESTFLLKHLPISNISEVPDLDEEYREVMRDFAKRLEKLAEELLDLLCENLGLEKGYLKNAFYGSKGPNFGTIVSNYPPCPKPDLIYGLRAHTDAGGIALLFQDDKVSGLQLLKDGQWIDVPPMRHSIVVNLGDQLEVITNGKYKSVMHRVIAQKDGARMSLASFYNPGSDAVIYPAPALVEKEAEENKQVYPKFVFDDYMKLYAGLKFQAKEPRFEAMKAMETDVKMDPIATV,0.76
|
| 6 |
+
I184A:K158I:F91L:K172Y:K93Q,MENFPIISLDKVNGVERAATMEMIKDACENWGFFELVNHGIPREVMDTVEKMTKGHYKKCMEQRFKELVASKALEGVQAEVTDMDWESTFLLQHLPISNISEVPDLDEEYREVMRDFAKRLEKLAEELLDLLCENLGLEKGYLKNAFYGSKGPNFGTIVSNYPPCPKPDLIYGLRAHTDAGGIALLFQDDKVSGLQLLKDGQWIDVPPMRHSIVVNLGDQLEVITNGKYKSVMHRVIAQKDGARMSLASFYNPGSDAVIYPAPALVEKEAEENKQVYPKFVFDDYMKLYAGLKFQAKEPRFEAMKAMETDVKMDPIATV,0.84
|
| 7 |
+
I184A:K158I:F91L:K172Y:K93Q:T89A,MENFPIISLDKVNGVERAATMEMIKDACENWGFFELVNHGIPREVMDTVEKMTKGHYKKCMEQRFKELVASKALEGVQAEVTDMDWESAFLLQHLPISNISEVPDLDEEYREVMRDFAKRLEKLAEELLDLLCENLGLEKGYLKNAFYGSKGPNFGTIVSNYPPCPKPDLIYGLRAHTDAGGIALLFQDDKVSGLQLLKDGQWIDVPPMRHSIVVNLGDQLEVITNGKYKSVMHRVIAQKDGARMSLASFYNPGSDAVIYPAPALVEKEAEENKQVYPKFVFDDYMKLYAGLKFQAKEPRFEAMKAMETDVKMDPIATV,0.9
|
| 8 |
+
I184A:K158N,MENFPIISLDKVNGVERAATMEMIKDACENWGFFELVNHGIPREVMDTVEKMTKGHYKKCMEQRFKELVASKALEGVQAEVTDMDWESTFFLKHLPISNISEVPDLDEEYREVMRDFAKRLEKLAEELLDLLCENLGLEKGYLKNAFYGSKGPNFGTNVSNYPPCPKPDLIKGLRAHTDAGGIALLFQDDKVSGLQLLKDGQWIDVPPMRHSIVVNLGDQLEVITNGKYKSVMHRVIAQKDGARMSLASFYNPGSDAVIYPAPALVEKEAEENKQVYPKFVFDDYMKLYAGLKFQAKEPRFEAMKAMETDVKMDPIATV,-0.62
|
| 9 |
+
I184A:K158N:F250Y,MENFPIISLDKVNGVERAATMEMIKDACENWGFFELVNHGIPREVMDTVEKMTKGHYKKCMEQRFKELVASKALEGVQAEVTDMDWESTFFLKHLPISNISEVPDLDEEYREVMRDFAKRLEKLAEELLDLLCENLGLEKGYLKNAFYGSKGPNFGTNVSNYPPCPKPDLIKGLRAHTDAGGIALLFQDDKVSGLQLLKDGQWIDVPPMRHSIVVNLGDQLEVITNGKYKSVMHRVIAQKDGARMSLASYYNPGSDAVIYPAPALVEKEAEENKQVYPKFVFDDYMKLYAGLKFQAKEPRFEAMKAMETDVKMDPIATV,-0.74
|
| 10 |
+
I184A:K158N:F250Y:F91E,MENFPIISLDKVNGVERAATMEMIKDACENWGFFELVNHGIPREVMDTVEKMTKGHYKKCMEQRFKELVASKALEGVQAEVTDMDWESTFELKHLPISNISEVPDLDEEYREVMRDFAKRLEKLAEELLDLLCENLGLEKGYLKNAFYGSKGPNFGTNVSNYPPCPKPDLIKGLRAHTDAGGIALLFQDDKVSGLQLLKDGQWIDVPPMRHSIVVNLGDQLEVITNGKYKSVMHRVIAQKDGARMSLASYYNPGSDAVIYPAPALVEKEAEENKQVYPKFVFDDYMKLYAGLKFQAKEPRFEAMKAMETDVKMDPIATV,-0.74
|
| 11 |
+
M1M,MENFPIISLDKVNGVERAATMEMIKDACENWGFFELVNHGIPREVMDTVEKMTKGHYKKCMEQRFKELVASKALEGVQAEVTDMDWESTFFLKHLPISNISEVPDLDEEYREVMRDFAKRLEKLAEELLDLLCENLGLEKGYLKNAFYGSKGPNFGTKVSNYPPCPKPDLIKGLRAHTDAGGIILLFQDDKVSGLQLLKDGQWIDVPPMRHSIVVNLGDQLEVITNGKYKSVMHRVIAQKDGARMSLASFYNPGSDAVIYPAPALVEKEAEENKQVYPKFVFDDYMKLYAGLKFQAKEPRFEAMKAMETDVKMDPIATV,-0.8
|
mutant/stability/M1261_1BNI_A_ddG.csv
CHANGED
|
@@ -1,29 +1,29 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A32K:S28E,0.522
|
| 3 |
-
A43C:S80C,1.653333333333333
|
| 4 |
-
D12A:D8A,-0.695
|
| 5 |
-
D12A:D8A:R110A,0.0866666666666666
|
| 6 |
-
D12A:R110A,0.2966666666666667
|
| 7 |
-
D12A:T16R,-0.205
|
| 8 |
-
D54N:T26H,-5.005
|
| 9 |
-
D75N:R83K,-5.4
|
| 10 |
-
D8A:R110A,-0.47
|
| 11 |
-
D8A:V10A,-0.355
|
| 12 |
-
D93N:R69S,-3.49
|
| 13 |
-
G65S:K108R:K19R:K66A:Q15I:T16R,3.21
|
| 14 |
-
H102C:S85C,4.316666666666666
|
| 15 |
-
H18A:W94L,-2.33
|
| 16 |
-
H18G:W94L,-0.1766666666666666
|
| 17 |
-
H18K:W94L,-2.52
|
| 18 |
-
H18N:W94L,-1.735
|
| 19 |
-
H18R:W94L,-1.865
|
| 20 |
-
H18S:W94L,-2.695
|
| 21 |
-
I25V:I4A:I51V:Y78F,-5.2
|
| 22 |
-
I4A:I51V,-2.63
|
| 23 |
-
I4A:I76V,-1.86
|
| 24 |
-
I4A:Y78F,-2.53
|
| 25 |
-
K19R:Q15I:T16R,1.82
|
| 26 |
-
T16A:Y17A,0.1149999999999999
|
| 27 |
-
T16S:Y17A,-2.47
|
| 28 |
-
Y13A:Y17A,-3.5725
|
| 29 |
-
Y13F:Y17F,-1.23
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A32K:S28E,AQVINTFDGVADYLQTYHKLPDNYITKEEAQKLGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,0.522
|
| 3 |
+
A43C:S80C,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLCDVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTCGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,1.653333333333333
|
| 4 |
+
D12A:D8A,AQVINTFAGVAAYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-0.695
|
| 5 |
+
D12A:D8A:R110A,AQVINTFAGVAAYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIA,0.0866666666666666
|
| 6 |
+
D12A:R110A,AQVINTFDGVAAYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIA,0.2966666666666667
|
| 7 |
+
D12A:T16R,AQVINTFDGVAAYLQRYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-0.205
|
| 8 |
+
D54N:T26H,AQVINTFDGVADYLQTYHKLPDNYIHKSEAQALGWVASKGNLADVAPGKSIGGNIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-5.005
|
| 9 |
+
D75N:R83K,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREANINYTSGFKNSDRILYSSDWLIYKTTDHYQTFTKIR,-5.4
|
| 10 |
+
D8A:R110A,AQVINTFAGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIA,-0.47
|
| 11 |
+
D8A:V10A,AQVINTFAGAADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-0.355
|
| 12 |
+
D93N:R69S,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGSTWREADINYTSGFRNSDRILYSSNWLIYKTTDHYQTFTKIR,-3.49
|
| 13 |
+
G65S:K108R:K19R:K66A:Q15I:T16R,AQVINTFDGVADYLIRYHRLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPSASGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTRIR,3.21
|
| 14 |
+
H102C:S85C,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNCDRILYSSDWLIYKTTDCYQTFTKIR,4.316666666666666
|
| 15 |
+
H18A:W94L,AQVINTFDGVADYLQTYAKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDLLIYKTTDHYQTFTKIR,-2.33
|
| 16 |
+
H18G:W94L,AQVINTFDGVADYLQTYGKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDLLIYKTTDHYQTFTKIR,-0.1766666666666666
|
| 17 |
+
H18K:W94L,AQVINTFDGVADYLQTYKKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDLLIYKTTDHYQTFTKIR,-2.52
|
| 18 |
+
H18N:W94L,AQVINTFDGVADYLQTYNKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDLLIYKTTDHYQTFTKIR,-1.735
|
| 19 |
+
H18R:W94L,AQVINTFDGVADYLQTYRKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDLLIYKTTDHYQTFTKIR,-1.865
|
| 20 |
+
H18S:W94L,AQVINTFDGVADYLQTYSKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDLLIYKTTDHYQTFTKIR,-2.695
|
| 21 |
+
I25V:I4A:I51V:Y78F,AQVANTFDGVADYLQTYHKLPDNYVTKSEAQALGWVASKGNLADVAPGKSVGGDIFSNREGKLPGKSGRTWREADINFTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-5.2
|
| 22 |
+
I4A:I51V,AQVANTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSVGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-2.63
|
| 23 |
+
I4A:I76V,AQVANTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADVNYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-1.86
|
| 24 |
+
I4A:Y78F,AQVANTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINFTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-2.53
|
| 25 |
+
K19R:Q15I:T16R,AQVINTFDGVADYLIRYHRLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,1.82
|
| 26 |
+
T16A:Y17A,AQVINTFDGVADYLQAAHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,0.1149999999999999
|
| 27 |
+
T16S:Y17A,AQVINTFDGVADYLQSAHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-2.47
|
| 28 |
+
Y13A:Y17A,AQVINTFDGVADALQTAHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-3.5725
|
| 29 |
+
Y13F:Y17F,AQVINTFDGVADFLQTFHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-1.23
|
mutant/stability/M1261_1C9O_A_ddG.csv
CHANGED
|
@@ -1,12 +1,12 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
E21A:R3E,-2.69896
|
| 3 |
-
E46A:L66E,-1.11164375
|
| 4 |
-
E46A:L66E:R3E,-2.866152
|
| 5 |
-
E46A:R3E,-1.19424925
|
| 6 |
-
E50W:L66C,-2.59107675
|
| 7 |
-
E50W:Q2C,-0.9539792
|
| 8 |
-
E50W:S24C,1.3877787807814457e-17
|
| 9 |
-
F38W:L66C,0.1619422999999998
|
| 10 |
-
F38W:N11C,-0.1695538399999999
|
| 11 |
-
G23Q:S24D,-0.02429805
|
| 12 |
-
L66E:R3E,-3.4393825
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
E21A:R3E,MQEGKVKWFNNEKGYGFIEVAGGSDVFVHFTAIQGEGFKTLEEGQEVSFEIVQGNRGPQAANVVKL,-2.69896
|
| 3 |
+
E46A:L66E,MQRGKVKWFNNEKGYGFIEVEGGSDVFVHFTAIQGEGFKTLEEGQAVSFEIVQGNRGPQAANVVKE,-1.11164375
|
| 4 |
+
E46A:L66E:R3E,MQEGKVKWFNNEKGYGFIEVEGGSDVFVHFTAIQGEGFKTLEEGQAVSFEIVQGNRGPQAANVVKE,-2.866152
|
| 5 |
+
E46A:R3E,MQEGKVKWFNNEKGYGFIEVEGGSDVFVHFTAIQGEGFKTLEEGQAVSFEIVQGNRGPQAANVVKL,-1.19424925
|
| 6 |
+
E50W:L66C,MQRGKVKWFNNEKGYGFIEVEGGSDVFVHFTAIQGEGFKTLEEGQEVSFWIVQGNRGPQAANVVKC,-2.59107675
|
| 7 |
+
E50W:Q2C,MCRGKVKWFNNEKGYGFIEVEGGSDVFVHFTAIQGEGFKTLEEGQEVSFWIVQGNRGPQAANVVKL,-0.9539792
|
| 8 |
+
E50W:S24C,MQRGKVKWFNNEKGYGFIEVEGGCDVFVHFTAIQGEGFKTLEEGQEVSFWIVQGNRGPQAANVVKL,1.3877787807814457e-17
|
| 9 |
+
F38W:L66C,MQRGKVKWFNNEKGYGFIEVEGGSDVFVHFTAIQGEGWKTLEEGQEVSFEIVQGNRGPQAANVVKC,0.1619422999999998
|
| 10 |
+
F38W:N11C,MQRGKVKWFNCEKGYGFIEVEGGSDVFVHFTAIQGEGWKTLEEGQEVSFEIVQGNRGPQAANVVKL,-0.1695538399999999
|
| 11 |
+
G23Q:S24D,MQRGKVKWFNNEKGYGFIEVEGQDDVFVHFTAIQGEGFKTLEEGQEVSFEIVQGNRGPQAANVVKL,-0.02429805
|
| 12 |
+
L66E:R3E,MQEGKVKWFNNEKGYGFIEVEGGSDVFVHFTAIQGEGFKTLEEGQEVSFEIVQGNRGPQAANVVKE,-3.4393825
|
mutant/stability/M1261_1CSP_A_ddG.csv
CHANGED
|
@@ -1,31 +1,31 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A46K:E3R:E66L:S48R,2.794498
|
| 3 |
-
A46K:E3R:S48R,3.367729
|
| 4 |
-
A46K:E43G:S48R,2.818383
|
| 5 |
-
A46K:E43K:S48K,2.890037
|
| 6 |
-
A46K:E43S:S48K,2.603421
|
| 7 |
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|
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|
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| 19 |
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| 20 |
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E3K:E66L:K65I:M1R,4.800805
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| 21 |
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E3K:K65I:M1R,4.991880999999999
|
| 22 |
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E3R:E66L,2.4604599999999994
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E66K:M1R,2.627306
|
| 31 |
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N55S:Q59R,-0.1671919999999999
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|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
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A46K:E3R:E66L:S48R,MLRGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEGQKVRFEIVEGNRGPQAANVTKLA,2.794498
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E3R:F15A:F27A,MLRGKVKWFNSEKGAGFIEVEGQDDVAVHFSAIQGEGFKTLEEGQAVSFEIVEGNRGPQAANVTKEA,0.0
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E3R:V20Q,MLRGKVKWFNSEKGFGFIEQEGQDDVFVHFSAIQGEGFKTLEEGQAVSFEIVEGNRGPQAANVTKEA,-1.73760475
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| 29 |
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| 30 |
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| 31 |
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|
mutant/stability/M1261_1EY0_A_ddG.csv
CHANGED
|
@@ -1,233 +1,233 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A130G:E75V,-3.4
|
| 3 |
-
A130G:G79S,-3.68
|
| 4 |
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A130G:L37A,-2.53
|
| 5 |
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A130G:L7A,-2.46
|
| 6 |
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A130G:V23F,-3.5
|
| 7 |
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A69T:A90S,-4.7
|
| 8 |
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A69T:E75V,-4.35
|
| 9 |
-
A69T:I18M,-3.52
|
| 10 |
-
A69T:L37A,-4.13
|
| 11 |
-
A69T:V23F,-4.0
|
| 12 |
-
A90S:E75V,-3.6
|
| 13 |
-
A90S:I18M,-2.7680952381428567
|
| 14 |
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A90S:L37A,-3.32
|
| 15 |
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A90S:T33S,-3.16
|
| 16 |
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A90S:V23F,-3.31
|
| 17 |
-
E73A:V74A,-5.2
|
| 18 |
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E75V:G79S,-4.67
|
| 19 |
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E75V:I15V,-2.83
|
| 20 |
-
E75V:I72V,-3.12
|
| 21 |
-
E75V:I92V,-2.05
|
| 22 |
-
E75V:L37A,-2.47
|
| 23 |
-
E75V:L7A,-3.64
|
| 24 |
-
E75V:P117L,-1.61
|
| 25 |
-
E75V:T33S,-3.21
|
| 26 |
-
E75V:V23F,-4.79
|
| 27 |
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E75V:Y113A,-1.55
|
| 28 |
-
E75V:Y85A,-2.51
|
| 29 |
-
F61A:T62A,-4.6
|
| 30 |
-
F76V:H124L,0.0
|
| 31 |
-
F76W:W140H,-1.0
|
| 32 |
-
G79D:N118D,-2.58
|
| 33 |
-
G79S:G88V:V66L,-0.4111111111111112
|
| 34 |
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G79S:H124L,1.77
|
| 35 |
-
G79S:I15V,-3.1
|
| 36 |
-
G79S:I72V,-3.61
|
| 37 |
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G79S:I92V,-2.55
|
| 38 |
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G79S:L37A,-1.83
|
| 39 |
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G79S:L7A,-2.77
|
| 40 |
-
G79S:N118D,-2.79
|
| 41 |
-
G79S:P117L,-2.08
|
| 42 |
-
G79S:V23F,-4.75
|
| 43 |
-
G79S:V66L,-3.5
|
| 44 |
-
G79S:Y113A,-2.22
|
| 45 |
-
G79S:Y85A,-2.69
|
| 46 |
-
G88V:T62A,-3.2
|
| 47 |
-
G88V:T62G,-3.66
|
| 48 |
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G88V:V66L,0.1647619047619048
|
| 49 |
-
I15V:I72V,-2.005
|
| 50 |
-
I15V:L37A,-2.17
|
| 51 |
-
I15V:L7A,-2.08
|
| 52 |
-
I15V:V23F,-2.59
|
| 53 |
-
I15V:Y113A,-0.62
|
| 54 |
-
I15V:Y85V,-1.06
|
| 55 |
-
I18M:T33S,-2.0
|
| 56 |
-
I72L:I92L,-0.7
|
| 57 |
-
I72L:I92L:V66I,-2.3
|
| 58 |
-
I72L:I92L:V66I:V99I,-3.3
|
| 59 |
-
I72L:I92L:V66I:V99L,-3.0
|
| 60 |
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I72L:I92L:V66L,-1.5
|
| 61 |
-
I72L:I92L:V66L:V99I,-1.9
|
| 62 |
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I72L:I92L:V66L:V99L,-1.3
|
| 63 |
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I72L:I92L:V99I,-1.4
|
| 64 |
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|
| 65 |
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I72L:I92V,-0.7
|
| 66 |
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I72L:I92V:V66I,-1.4
|
| 67 |
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| 68 |
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I72L:I92V:V66I:V99L,-1.8
|
| 69 |
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I72L:I92V:V66L,-0.8
|
| 70 |
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I72L:I92V:V66L:V99I,-1.0
|
| 71 |
-
I72L:I92V:V66L:V99L,-0.7
|
| 72 |
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I72L:I92V:V99I,-0.7
|
| 73 |
-
I72L:I92V:V99L,-1.1
|
| 74 |
-
I72L:L25I,-1.7000000000000002
|
| 75 |
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I72L:L25I:V23I,-1.7000000000000002
|
| 76 |
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|
| 77 |
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I72L:L25I:V23I:V66L,-2.7
|
| 78 |
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I72L:L25I:V23L,-1.4
|
| 79 |
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I72L:L25I:V23L:V66I,-3.2
|
| 80 |
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I72L:L25I:V23L:V66L,-2.4
|
| 81 |
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I72L:L25I:V66I,-3.0
|
| 82 |
-
I72L:L25I:V66L,-2.3
|
| 83 |
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I72L:L25V,-1.6
|
| 84 |
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I72L:L25V:V23I,-1.1
|
| 85 |
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I72L:L25V:V23I:V66I,-2.8
|
| 86 |
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I72L:L25V:V23I:V66L,-2.5
|
| 87 |
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I72L:L25V:V23L,-1.5
|
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I72L:L25V:V23L:V66I,-2.8
|
| 89 |
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I72L:L25V:V23L:V66L,-2.0
|
| 90 |
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I72L:L25V:V66I,-3.0
|
| 91 |
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I72L:L25V:V66L,-2.2
|
| 92 |
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I72L:V23I,-0.5
|
| 93 |
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I72L:V23I:V66I,-2.0
|
| 94 |
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I72L:V23I:V66L,-1.4
|
| 95 |
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I72L:V23L,-0.4
|
| 96 |
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I72L:V23L:V66I,-2.0
|
| 97 |
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I72L:V23L:V66L,-1.3
|
| 98 |
-
I72L:V66I,-1.7000000000000002
|
| 99 |
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I72L:V66I:V99I,-1.9
|
| 100 |
-
I72L:V66I:V99L,-1.9
|
| 101 |
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I72L:V66L,-0.9
|
| 102 |
-
I72L:V66L:V99I,-1.0
|
| 103 |
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I72L:V66L:V99L,-0.8
|
| 104 |
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I72L:V99I,-0.5
|
| 105 |
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I72L:V99L,-0.8
|
| 106 |
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I72V:I92L,-1.8
|
| 107 |
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I72V:I92L:V66I,-2.0
|
| 108 |
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I72V:I92L:V66I:V99I,-2.0
|
| 109 |
-
I72V:I92L:V66I:V99L,-2.4
|
| 110 |
-
I72V:I92L:V66L,-1.3
|
| 111 |
-
I72V:I92L:V66L:V99I,-1.8
|
| 112 |
-
I72V:I92L:V66L:V99L,-1.4
|
| 113 |
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I72V:I92L:V99I,-2.1
|
| 114 |
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I72V:I92L:V99L,-2.4
|
| 115 |
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I72V:I92V,-1.7000000000000002
|
| 116 |
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I72V:I92V:L25I:V23I:V66L,-2.3
|
| 117 |
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I72V:I92V:L25V:V23I,-2.4
|
| 118 |
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I72V:I92V:L25V:V23I:V66L,-1.9
|
| 119 |
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I72V:I92V:L25V:V23I:V99I,-2.7
|
| 120 |
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I72V:I92V:L25V:V23I:V99L,-3.0
|
| 121 |
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I72V:I92V:L25V:V23L:V66L,-2.2
|
| 122 |
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I72V:I92V:V23I:V66L,-0.6000000000000001
|
| 123 |
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I72V:I92V:V66I,-1.4
|
| 124 |
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I72V:I92V:V66I:V99I,-1.0
|
| 125 |
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I72V:I92V:V66I:V99L,-1.7000000000000002
|
| 126 |
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I72V:I92V:V66L,-0.5
|
| 127 |
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I72V:I92V:V66L:V99I,-0.8
|
| 128 |
-
I72V:I92V:V66L:V99L,-0.7
|
| 129 |
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I72V:I92V:V99I,-1.4
|
| 130 |
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I72V:I92V:V99L,-2.0
|
| 131 |
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I72V:L25I,-3.0
|
| 132 |
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I72V:L25I:V23I,-2.8
|
| 133 |
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I72V:L25I:V23I:V66I,-3.2
|
| 134 |
-
I72V:L25I:V23I:V66L,-2.6
|
| 135 |
-
I72V:L25I:V23L,-2.5
|
| 136 |
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I72V:L25I:V23L:V66I,-3.4
|
| 137 |
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I72V:L25I:V23L:V66L,-2.6
|
| 138 |
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|
| 139 |
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|
| 140 |
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I72V:L25V,-2.9
|
| 141 |
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I72V:L25V:V23I,-2.3
|
| 142 |
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I72V:L25V:V23I:V66I,-3.0
|
| 143 |
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|
| 144 |
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I72V:L25V:V23L,-2.8
|
| 145 |
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I72V:L25V:V23L:V66I,-3.4
|
| 146 |
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I72V:L25V:V23L:V66L,-2.5
|
| 147 |
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I72V:L25V:V66I,-3.1
|
| 148 |
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I72V:L25V:V66L,-2.0
|
| 149 |
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I72V:L37A,-2.78
|
| 150 |
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I72V:L7A,-2.41
|
| 151 |
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I72V:V23F,-2.9
|
| 152 |
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I72V:V23I,-1.1
|
| 153 |
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I72V:V23I:V66I,-1.6
|
| 154 |
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I72V:V23I:V66L,-0.9
|
| 155 |
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I72V:V23L,-1.1
|
| 156 |
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I72V:V23L:V66I,-1.6
|
| 157 |
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I72V:V23L:V66L,-1.3
|
| 158 |
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I72V:V66I,-1.2
|
| 159 |
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I72V:V66I:V99I,-0.8
|
| 160 |
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I72V:V66I:V99L,-1.6
|
| 161 |
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I72V:V66L,-0.5
|
| 162 |
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I72V:V66L:V99I,-0.8
|
| 163 |
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I72V:V66L:V99L,-0.5
|
| 164 |
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I72V:V99I,-1.2
|
| 165 |
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I72V:V99L,-1.7000000000000002
|
| 166 |
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I72V:Y113A,-0.94
|
| 167 |
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I72V:Y85A,-1.6
|
| 168 |
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I92L:V66I,-1.9
|
| 169 |
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|
| 170 |
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|
| 171 |
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|
| 172 |
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|
| 173 |
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|
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|
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I92L:V99L,-1.3
|
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I92V:L37A,-1.77
|
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|
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|
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|
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|
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|
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|
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|
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|
| 192 |
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L25I:V23L:V66I,-3.1
|
| 193 |
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L25I:V23L:V66L,-2.4
|
| 194 |
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L25I:V66I,-3.0
|
| 195 |
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L25I:V66L,-1.9
|
| 196 |
-
L25V:V23I,-1.4
|
| 197 |
-
L25V:V23I:V66I,-2.7
|
| 198 |
-
L25V:V23I:V66L,-2.1
|
| 199 |
-
L25V:V23L,-1.8
|
| 200 |
-
L25V:V23L:V66I,-2.8
|
| 201 |
-
L25V:V23L:V66L,-2.0
|
| 202 |
-
L25V:V66I,-2.9
|
| 203 |
-
L25V:V66L,-1.8
|
| 204 |
-
L36E:V23K,11.3
|
| 205 |
-
L36K:V23E,9.3
|
| 206 |
-
L37A:L38A,-1.8
|
| 207 |
-
L37A:L7A,-1.65
|
| 208 |
-
L37A:N118D,-1.72
|
| 209 |
-
L37A:P117L,-1.69
|
| 210 |
-
L37A:T33S,-2.21
|
| 211 |
-
L37A:V23F,-3.17
|
| 212 |
-
L37A:Y113A,-1.46
|
| 213 |
-
L37A:Y85A,-1.98
|
| 214 |
-
L38A:V39A,-4.0
|
| 215 |
-
L7A:V23F,-3.65
|
| 216 |
-
L7A:Y113A,-1.1
|
| 217 |
-
L7A:Y85A,-1.6
|
| 218 |
-
M32A:T33A,-3.3
|
| 219 |
-
M65A:V66A,-4.5
|
| 220 |
-
N118D:P117L,-1.0
|
| 221 |
-
T33S:V23F,-2.72
|
| 222 |
-
T62A:V66L,-2.4
|
| 223 |
-
V23F:Y113A,-1.89
|
| 224 |
-
V23F:Y85A,-2.51
|
| 225 |
-
V23I:V66I,-1.5
|
| 226 |
-
V23I:V66L,-1.0
|
| 227 |
-
V23L:V66I,-1.5
|
| 228 |
-
V23L:V66L,-1.1
|
| 229 |
-
V66I:V99I,-0.7
|
| 230 |
-
V66I:V99L,-1.3
|
| 231 |
-
V66L:V99I,-0.6000000000000001
|
| 232 |
-
V66L:V99L,0.0
|
| 233 |
-
Y113A:Y85A,-0.23
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A130G:E75V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVVFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEGQAKKEKLNIWSEDNADSGQ,-3.4
|
| 3 |
+
A130G:G79S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKSQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEGQAKKEKLNIWSEDNADSGQ,-3.68
|
| 4 |
+
A130G:L37A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLALVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEGQAKKEKLNIWSEDNADSGQ,-2.53
|
| 5 |
+
A130G:L7A,ATSTKKAHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEGQAKKEKLNIWSEDNADSGQ,-2.46
|
| 6 |
+
A130G:V23F,ATSTKKLHKEPATLIKAIDGDTFKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEGQAKKEKLNIWSEDNADSGQ,-3.5
|
| 7 |
+
A69T:A90S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENTKKIEVEFDKGQRTDKYGRGLSYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.7
|
| 8 |
+
A69T:E75V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENTKKIEVVFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.35
|
| 9 |
+
A69T:I18M,ATSTKKLHKEPATLIKAMDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENTKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.52
|
| 10 |
+
A69T:L37A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLALVDTPETKHPKKGVEKYGPEASAFTKKMVENTKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.13
|
| 11 |
+
A69T:V23F,ATSTKKLHKEPATLIKAIDGDTFKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENTKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.0
|
| 12 |
+
A90S:E75V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVVFDKGQRTDKYGRGLSYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.6
|
| 13 |
+
A90S:I18M,ATSTKKLHKEPATLIKAMDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLSYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.7680952381428567
|
| 14 |
+
A90S:L37A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLALVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLSYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.32
|
| 15 |
+
A90S:T33S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMSFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLSYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.16
|
| 16 |
+
A90S:V23F,ATSTKKLHKEPATLIKAIDGDTFKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLSYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.31
|
| 17 |
+
E73A:V74A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIAAEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-5.2
|
| 18 |
+
E75V:G79S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVVFDKSQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.67
|
| 19 |
+
E75V:I15V,ATSTKKLHKEPATLVKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVVFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.83
|
| 20 |
+
E75V:I72V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVVFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.12
|
| 21 |
+
E75V:I92V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVVFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.05
|
| 22 |
+
E75V:L37A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLALVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVVFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.47
|
| 23 |
+
E75V:L7A,ATSTKKAHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVVFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.64
|
| 24 |
+
E75V:P117L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVVFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKLNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.61
|
| 25 |
+
E75V:T33S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMSFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVVFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.21
|
| 26 |
+
E75V:V23F,ATSTKKLHKEPATLIKAIDGDTFKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVVFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.79
|
| 27 |
+
E75V:Y113A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVVFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAAVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.55
|
| 28 |
+
E75V:Y85A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVVFDKGQRTDKAGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.51
|
| 29 |
+
F61A:T62A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAAAKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.6
|
| 30 |
+
F76V:H124L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEVDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQLLRKSEAQAKKEKLNIWSEDNADSGQ,0.0
|
| 31 |
+
F76W:W140H,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEWDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIHSEDNADSGQ,-1.0
|
| 32 |
+
G79D:N118D,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKDQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPDNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.58
|
| 33 |
+
G79S:G88V:V66L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKSQRTDKYGRVLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.4111111111111112
|
| 34 |
+
G79S:H124L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKSQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQLLRKSEAQAKKEKLNIWSEDNADSGQ,1.77
|
| 35 |
+
G79S:I15V,ATSTKKLHKEPATLVKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKSQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.1
|
| 36 |
+
G79S:I72V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKSQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.61
|
| 37 |
+
G79S:I92V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKSQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.55
|
| 38 |
+
G79S:L37A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLALVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKSQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.83
|
| 39 |
+
G79S:L7A,ATSTKKAHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKSQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.77
|
| 40 |
+
G79S:N118D,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKSQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPDNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.79
|
| 41 |
+
G79S:P117L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKSQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKLNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.08
|
| 42 |
+
G79S:V23F,ATSTKKLHKEPATLIKAIDGDTFKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKSQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.75
|
| 43 |
+
G79S:V66L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKSQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.5
|
| 44 |
+
G79S:Y113A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKSQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAAVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.22
|
| 45 |
+
G79S:Y85A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKSQRTDKAGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.69
|
| 46 |
+
G88V:T62A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFAKKMVENAKKIEVEFDKGQRTDKYGRVLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.2
|
| 47 |
+
G88V:T62G,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFGKKMVENAKKIEVEFDKGQRTDKYGRVLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.66
|
| 48 |
+
G88V:V66L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRVLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,0.1647619047619048
|
| 49 |
+
I15V:I72V,ATSTKKLHKEPATLVKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.005
|
| 50 |
+
I15V:L37A,ATSTKKLHKEPATLVKAIDGDTVKLMYKGQPMTFRLALVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.17
|
| 51 |
+
I15V:L7A,ATSTKKAHKEPATLVKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.08
|
| 52 |
+
I15V:V23F,ATSTKKLHKEPATLVKAIDGDTFKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.59
|
| 53 |
+
I15V:Y113A,ATSTKKLHKEPATLVKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAAVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.62
|
| 54 |
+
I15V:Y85V,ATSTKKLHKEPATLVKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKVGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.06
|
| 55 |
+
I18M:T33S,ATSTKKLHKEPATLIKAMDGDTVKLMYKGQPMSFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.0
|
| 56 |
+
I72L:I92L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKLEVEFDKGQRTDKYGRGLAYLYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.7
|
| 57 |
+
I72L:I92L:V66I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYLYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.3
|
| 58 |
+
I72L:I92L:V66I:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYLYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.3
|
| 59 |
+
I72L:I92L:V66I:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYLYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.0
|
| 60 |
+
I72L:I92L:V66L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYLYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.5
|
| 61 |
+
I72L:I92L:V66L:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYLYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.9
|
| 62 |
+
I72L:I92L:V66L:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYLYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.3
|
| 63 |
+
I72L:I92L:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKLEVEFDKGQRTDKYGRGLAYLYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.4
|
| 64 |
+
I72L:I92L:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKLEVEFDKGQRTDKYGRGLAYLYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.4
|
| 65 |
+
I72L:I92V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKLEVEFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.7
|
| 66 |
+
I72L:I92V:V66I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.4
|
| 67 |
+
I72L:I92V:V66I:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYVYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.6
|
| 68 |
+
I72L:I92V:V66I:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYVYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.8
|
| 69 |
+
I72L:I92V:V66L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.8
|
| 70 |
+
I72L:I92V:V66L:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYVYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.0
|
| 71 |
+
I72L:I92V:V66L:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYVYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.7
|
| 72 |
+
I72L:I92V:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKLEVEFDKGQRTDKYGRGLAYVYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.7
|
| 73 |
+
I72L:I92V:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKLEVEFDKGQRTDKYGRGLAYVYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.1
|
| 74 |
+
I72L:L25I,ATSTKKLHKEPATLIKAIDGDTVKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.7000000000000002
|
| 75 |
+
I72L:L25I:V23I,ATSTKKLHKEPATLIKAIDGDTIKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.7000000000000002
|
| 76 |
+
I72L:L25I:V23I:V66I,ATSTKKLHKEPATLIKAIDGDTIKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.2
|
| 77 |
+
I72L:L25I:V23I:V66L,ATSTKKLHKEPATLIKAIDGDTIKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.7
|
| 78 |
+
I72L:L25I:V23L,ATSTKKLHKEPATLIKAIDGDTLKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.4
|
| 79 |
+
I72L:L25I:V23L:V66I,ATSTKKLHKEPATLIKAIDGDTLKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.2
|
| 80 |
+
I72L:L25I:V23L:V66L,ATSTKKLHKEPATLIKAIDGDTLKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.4
|
| 81 |
+
I72L:L25I:V66I,ATSTKKLHKEPATLIKAIDGDTVKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.0
|
| 82 |
+
I72L:L25I:V66L,ATSTKKLHKEPATLIKAIDGDTVKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.3
|
| 83 |
+
I72L:L25V,ATSTKKLHKEPATLIKAIDGDTVKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.6
|
| 84 |
+
I72L:L25V:V23I,ATSTKKLHKEPATLIKAIDGDTIKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.1
|
| 85 |
+
I72L:L25V:V23I:V66I,ATSTKKLHKEPATLIKAIDGDTIKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.8
|
| 86 |
+
I72L:L25V:V23I:V66L,ATSTKKLHKEPATLIKAIDGDTIKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.5
|
| 87 |
+
I72L:L25V:V23L,ATSTKKLHKEPATLIKAIDGDTLKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.5
|
| 88 |
+
I72L:L25V:V23L:V66I,ATSTKKLHKEPATLIKAIDGDTLKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.8
|
| 89 |
+
I72L:L25V:V23L:V66L,ATSTKKLHKEPATLIKAIDGDTLKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.0
|
| 90 |
+
I72L:L25V:V66I,ATSTKKLHKEPATLIKAIDGDTVKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.0
|
| 91 |
+
I72L:L25V:V66L,ATSTKKLHKEPATLIKAIDGDTVKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.2
|
| 92 |
+
I72L:V23I,ATSTKKLHKEPATLIKAIDGDTIKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.5
|
| 93 |
+
I72L:V23I:V66I,ATSTKKLHKEPATLIKAIDGDTIKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.0
|
| 94 |
+
I72L:V23I:V66L,ATSTKKLHKEPATLIKAIDGDTIKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.4
|
| 95 |
+
I72L:V23L,ATSTKKLHKEPATLIKAIDGDTLKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.4
|
| 96 |
+
I72L:V23L:V66I,ATSTKKLHKEPATLIKAIDGDTLKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.0
|
| 97 |
+
I72L:V23L:V66L,ATSTKKLHKEPATLIKAIDGDTLKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.3
|
| 98 |
+
I72L:V66I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.7000000000000002
|
| 99 |
+
I72L:V66I:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.9
|
| 100 |
+
I72L:V66I:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.9
|
| 101 |
+
I72L:V66L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.9
|
| 102 |
+
I72L:V66L:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.0
|
| 103 |
+
I72L:V66L:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.8
|
| 104 |
+
I72L:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.5
|
| 105 |
+
I72L:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKLEVEFDKGQRTDKYGRGLAYIYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.8
|
| 106 |
+
I72V:I92L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYLYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.8
|
| 107 |
+
I72V:I92L:V66I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYLYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.0
|
| 108 |
+
I72V:I92L:V66I:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYLYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.0
|
| 109 |
+
I72V:I92L:V66I:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYLYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.4
|
| 110 |
+
I72V:I92L:V66L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYLYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.3
|
| 111 |
+
I72V:I92L:V66L:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYLYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.8
|
| 112 |
+
I72V:I92L:V66L:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYLYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.4
|
| 113 |
+
I72V:I92L:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYLYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.1
|
| 114 |
+
I72V:I92L:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYLYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.4
|
| 115 |
+
I72V:I92V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.7000000000000002
|
| 116 |
+
I72V:I92V:L25I:V23I:V66L,ATSTKKLHKEPATLIKAIDGDTIKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.3
|
| 117 |
+
I72V:I92V:L25V:V23I,ATSTKKLHKEPATLIKAIDGDTIKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.4
|
| 118 |
+
I72V:I92V:L25V:V23I:V66L,ATSTKKLHKEPATLIKAIDGDTIKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.9
|
| 119 |
+
I72V:I92V:L25V:V23I:V99I,ATSTKKLHKEPATLIKAIDGDTIKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYVYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.7
|
| 120 |
+
I72V:I92V:L25V:V23I:V99L,ATSTKKLHKEPATLIKAIDGDTIKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYVYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.0
|
| 121 |
+
I72V:I92V:L25V:V23L:V66L,ATSTKKLHKEPATLIKAIDGDTLKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.2
|
| 122 |
+
I72V:I92V:V23I:V66L,ATSTKKLHKEPATLIKAIDGDTIKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.6000000000000001
|
| 123 |
+
I72V:I92V:V66I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.4
|
| 124 |
+
I72V:I92V:V66I:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYVYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.0
|
| 125 |
+
I72V:I92V:V66I:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYVYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.7000000000000002
|
| 126 |
+
I72V:I92V:V66L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.5
|
| 127 |
+
I72V:I92V:V66L:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYVYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.8
|
| 128 |
+
I72V:I92V:V66L:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYVYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.7
|
| 129 |
+
I72V:I92V:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYVYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.4
|
| 130 |
+
I72V:I92V:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYVYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.0
|
| 131 |
+
I72V:L25I,ATSTKKLHKEPATLIKAIDGDTVKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.0
|
| 132 |
+
I72V:L25I:V23I,ATSTKKLHKEPATLIKAIDGDTIKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.8
|
| 133 |
+
I72V:L25I:V23I:V66I,ATSTKKLHKEPATLIKAIDGDTIKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.2
|
| 134 |
+
I72V:L25I:V23I:V66L,ATSTKKLHKEPATLIKAIDGDTIKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.6
|
| 135 |
+
I72V:L25I:V23L,ATSTKKLHKEPATLIKAIDGDTLKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.5
|
| 136 |
+
I72V:L25I:V23L:V66I,ATSTKKLHKEPATLIKAIDGDTLKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.4
|
| 137 |
+
I72V:L25I:V23L:V66L,ATSTKKLHKEPATLIKAIDGDTLKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.6
|
| 138 |
+
I72V:L25I:V66I,ATSTKKLHKEPATLIKAIDGDTVKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.2
|
| 139 |
+
I72V:L25I:V66L,ATSTKKLHKEPATLIKAIDGDTVKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.2
|
| 140 |
+
I72V:L25V,ATSTKKLHKEPATLIKAIDGDTVKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.9
|
| 141 |
+
I72V:L25V:V23I,ATSTKKLHKEPATLIKAIDGDTIKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.3
|
| 142 |
+
I72V:L25V:V23I:V66I,ATSTKKLHKEPATLIKAIDGDTIKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.0
|
| 143 |
+
I72V:L25V:V23I:V66L,ATSTKKLHKEPATLIKAIDGDTIKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.1
|
| 144 |
+
I72V:L25V:V23L,ATSTKKLHKEPATLIKAIDGDTLKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.8
|
| 145 |
+
I72V:L25V:V23L:V66I,ATSTKKLHKEPATLIKAIDGDTLKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.4
|
| 146 |
+
I72V:L25V:V23L:V66L,ATSTKKLHKEPATLIKAIDGDTLKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.5
|
| 147 |
+
I72V:L25V:V66I,ATSTKKLHKEPATLIKAIDGDTVKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.1
|
| 148 |
+
I72V:L25V:V66L,ATSTKKLHKEPATLIKAIDGDTVKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.0
|
| 149 |
+
I72V:L37A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLALVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.78
|
| 150 |
+
I72V:L7A,ATSTKKAHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.41
|
| 151 |
+
I72V:V23F,ATSTKKLHKEPATLIKAIDGDTFKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.9
|
| 152 |
+
I72V:V23I,ATSTKKLHKEPATLIKAIDGDTIKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.1
|
| 153 |
+
I72V:V23I:V66I,ATSTKKLHKEPATLIKAIDGDTIKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.6
|
| 154 |
+
I72V:V23I:V66L,ATSTKKLHKEPATLIKAIDGDTIKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.9
|
| 155 |
+
I72V:V23L,ATSTKKLHKEPATLIKAIDGDTLKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.1
|
| 156 |
+
I72V:V23L:V66I,ATSTKKLHKEPATLIKAIDGDTLKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.6
|
| 157 |
+
I72V:V23L:V66L,ATSTKKLHKEPATLIKAIDGDTLKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.3
|
| 158 |
+
I72V:V66I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.2
|
| 159 |
+
I72V:V66I:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.8
|
| 160 |
+
I72V:V66I:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.6
|
| 161 |
+
I72V:V66L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.5
|
| 162 |
+
I72V:V66L:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.8
|
| 163 |
+
I72V:V66L:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.5
|
| 164 |
+
I72V:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.2
|
| 165 |
+
I72V:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.7000000000000002
|
| 166 |
+
I72V:Y113A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAAVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.94
|
| 167 |
+
I72V:Y85A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKVEVEFDKGQRTDKAGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.6
|
| 168 |
+
I92L:V66I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEVEFDKGQRTDKYGRGLAYLYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.9
|
| 169 |
+
I92L:V66I:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEVEFDKGQRTDKYGRGLAYLYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.1
|
| 170 |
+
I92L:V66I:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEVEFDKGQRTDKYGRGLAYLYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.1
|
| 171 |
+
I92L:V66L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYLYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.0
|
| 172 |
+
I92L:V66L:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYLYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.4
|
| 173 |
+
I92L:V66L:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYLYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.7
|
| 174 |
+
I92L:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYLYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.9
|
| 175 |
+
I92L:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYLYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.3
|
| 176 |
+
I92V:L37A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLALVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.77
|
| 177 |
+
I92V:L7A,ATSTKKAHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.54
|
| 178 |
+
I92V:V23F,ATSTKKLHKEPATLIKAIDGDTFKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.01
|
| 179 |
+
I92V:V66I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEVEFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.7
|
| 180 |
+
I92V:V66I:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEVEFDKGQRTDKYGRGLAYVYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.5
|
| 181 |
+
I92V:V66I:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEVEFDKGQRTDKYGRGLAYVYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.9
|
| 182 |
+
I92V:V66L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYVYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,0.1
|
| 183 |
+
I92V:V66L:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYVYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.4
|
| 184 |
+
I92V:V66L:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYVYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,0.1
|
| 185 |
+
I92V:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYVYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.7
|
| 186 |
+
I92V:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYVYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.9
|
| 187 |
+
L25A:M26A,ATSTKKLHKEPATLIKAIDGDTVKAAYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.4
|
| 188 |
+
L25I:V23I,ATSTKKLHKEPATLIKAIDGDTIKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.7000000000000002
|
| 189 |
+
L25I:V23I:V66I,ATSTKKLHKEPATLIKAIDGDTIKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.9
|
| 190 |
+
L25I:V23I:V66L,ATSTKKLHKEPATLIKAIDGDTIKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.5
|
| 191 |
+
L25I:V23L,ATSTKKLHKEPATLIKAIDGDTLKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.5
|
| 192 |
+
L25I:V23L:V66I,ATSTKKLHKEPATLIKAIDGDTLKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.1
|
| 193 |
+
L25I:V23L:V66L,ATSTKKLHKEPATLIKAIDGDTLKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.4
|
| 194 |
+
L25I:V66I,ATSTKKLHKEPATLIKAIDGDTVKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.0
|
| 195 |
+
L25I:V66L,ATSTKKLHKEPATLIKAIDGDTVKIMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.9
|
| 196 |
+
L25V:V23I,ATSTKKLHKEPATLIKAIDGDTIKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.4
|
| 197 |
+
L25V:V23I:V66I,ATSTKKLHKEPATLIKAIDGDTIKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.7
|
| 198 |
+
L25V:V23I:V66L,ATSTKKLHKEPATLIKAIDGDTIKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.1
|
| 199 |
+
L25V:V23L,ATSTKKLHKEPATLIKAIDGDTLKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.8
|
| 200 |
+
L25V:V23L:V66I,ATSTKKLHKEPATLIKAIDGDTLKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.8
|
| 201 |
+
L25V:V23L:V66L,ATSTKKLHKEPATLIKAIDGDTLKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.0
|
| 202 |
+
L25V:V66I,ATSTKKLHKEPATLIKAIDGDTVKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.9
|
| 203 |
+
L25V:V66L,ATSTKKLHKEPATLIKAIDGDTVKVMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.8
|
| 204 |
+
L36E:V23K,ATSTKKLHKEPATLIKAIDGDTKKLMYKGQPMTFRELLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,11.3
|
| 205 |
+
L36K:V23E,ATSTKKLHKEPATLIKAIDGDTEKLMYKGQPMTFRKLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,9.3
|
| 206 |
+
L37A:L38A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLAAVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.8
|
| 207 |
+
L37A:L7A,ATSTKKAHKEPATLIKAIDGDTVKLMYKGQPMTFRLALVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.65
|
| 208 |
+
L37A:N118D,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLALVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPDNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.72
|
| 209 |
+
L37A:P117L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLALVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKLNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.69
|
| 210 |
+
L37A:T33S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMSFRLALVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.21
|
| 211 |
+
L37A:V23F,ATSTKKLHKEPATLIKAIDGDTFKLMYKGQPMTFRLALVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.17
|
| 212 |
+
L37A:Y113A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLALVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAAVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.46
|
| 213 |
+
L37A:Y85A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLALVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKAGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.98
|
| 214 |
+
L38A:V39A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLAADTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.0
|
| 215 |
+
L7A:V23F,ATSTKKAHKEPATLIKAIDGDTFKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.65
|
| 216 |
+
L7A:Y113A,ATSTKKAHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAAVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.1
|
| 217 |
+
L7A:Y85A,ATSTKKAHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKAGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.6
|
| 218 |
+
M32A:T33A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPAAFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.3
|
| 219 |
+
M65A:V66A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKAAENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.5
|
| 220 |
+
N118D:P117L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKLDNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.0
|
| 221 |
+
T33S:V23F,ATSTKKLHKEPATLIKAIDGDTFKLMYKGQPMSFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.72
|
| 222 |
+
T62A:V66L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFAKKMLENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.4
|
| 223 |
+
V23F:Y113A,ATSTKKLHKEPATLIKAIDGDTFKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAAVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.89
|
| 224 |
+
V23F:Y85A,ATSTKKLHKEPATLIKAIDGDTFKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKAGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.51
|
| 225 |
+
V23I:V66I,ATSTKKLHKEPATLIKAIDGDTIKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.5
|
| 226 |
+
V23I:V66L,ATSTKKLHKEPATLIKAIDGDTIKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.0
|
| 227 |
+
V23L:V66I,ATSTKKLHKEPATLIKAIDGDTLKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.5
|
| 228 |
+
V23L:V66L,ATSTKKLHKEPATLIKAIDGDTLKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.1
|
| 229 |
+
V66I:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.7
|
| 230 |
+
V66I:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMIENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.3
|
| 231 |
+
V66L:V99I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMINEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.6000000000000001
|
| 232 |
+
V66L:V99L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMLNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,0.0
|
| 233 |
+
Y113A:Y85A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKAGRGLAYIYADGKMVNEALVRQGLAKVAAVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.23
|
mutant/stability/M1261_1LNI_A_ddG.csv
CHANGED
|
@@ -1,17 +1,17 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
D17K:D1K:D25K:D79K:E41K:E74K,0.4499999999999999
|
| 3 |
-
D17K:D1K:D25K:D79K:E41K:E74K:S31K,0.1
|
| 4 |
-
D17K:D1K:D25K:E41K:E74K,0.1
|
| 5 |
-
D17K:D1K:E41K,-1.0
|
| 6 |
-
D25K:D79A:E74K:Q77G:S31P:S42G:S48P:T76P,3.5500000000000003
|
| 7 |
-
D25K:D79F:E74K:I70D:Q77G:S31P:S42G:S48P:T76P,-6.55
|
| 8 |
-
D25K:D79F:E74K:I92A:Q77G:S31P:S42G:S48P:T76P,-0.6500000000000001
|
| 9 |
-
D25K:D79F:E74K:I92D:Q77G:S31P:S42G:S48P:T76P,-4.65
|
| 10 |
-
D25K:D79F:E74K:Q77G:S31P:S42G:S48P:T76P,7.0
|
| 11 |
-
D25K:D79F:E74K:Q77G:S31P:S42G:S48P:T76P:Y80A,-2.35
|
| 12 |
-
D25K:E74K,0.6333333333333333
|
| 13 |
-
D25K:E74K:I92D:Q77G:S31P:S42G:S48P:T76P,-7.35
|
| 14 |
-
D25K:E74K:Q77G:S31P:S42G:S48P:T76P,4.6
|
| 15 |
-
R40E:R63E,0.25
|
| 16 |
-
R40E:R63E:R65A,-1.15
|
| 17 |
-
R40E:R63E:R65A:R68A:R69A,0.1
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
D17K:D1K:D25K:D79K:E41K:E74K,KVSGTVCLSALPPEATKTLNLIASKGPFPYSQDGVVFQNRKSVLPTQSYGYYHEYTVITPGARTRGTRRIITGKATQEKYYTGDHYATFSLIDQTC,0.4499999999999999
|
| 3 |
+
D17K:D1K:D25K:D79K:E41K:E74K:S31K,KVSGTVCLSALPPEATKTLNLIASKGPFPYKQDGVVFQNRKSVLPTQSYGYYHEYTVITPGARTRGTRRIITGKATQEKYYTGDHYATFSLIDQTC,0.1
|
| 4 |
+
D17K:D1K:D25K:E41K:E74K,KVSGTVCLSALPPEATKTLNLIASKGPFPYSQDGVVFQNRKSVLPTQSYGYYHEYTVITPGARTRGTRRIITGKATQEDYYTGDHYATFSLIDQTC,0.1
|
| 5 |
+
D17K:D1K:E41K,KVSGTVCLSALPPEATKTLNLIASDGPFPYSQDGVVFQNRKSVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-1.0
|
| 6 |
+
D25K:D79A:E74K:Q77G:S31P:S42G:S48P:T76P,DVSGTVCLSALPPEATDTLNLIASKGPFPYPQDGVVFQNREGVLPTQPYGYYHEYTVITPGARTRGTRRIITGKAPGEAYYTGDHYATFSLIDQTC,3.5500000000000003
|
| 7 |
+
D25K:D79F:E74K:I70D:Q77G:S31P:S42G:S48P:T76P,DVSGTVCLSALPPEATDTLNLIASKGPFPYPQDGVVFQNREGVLPTQPYGYYHEYTVITPGARTRGTRRDITGKAPGEFYYTGDHYATFSLIDQTC,-6.55
|
| 8 |
+
D25K:D79F:E74K:I92A:Q77G:S31P:S42G:S48P:T76P,DVSGTVCLSALPPEATDTLNLIASKGPFPYPQDGVVFQNREGVLPTQPYGYYHEYTVITPGARTRGTRRIITGKAPGEFYYTGDHYATFSLADQTC,-0.6500000000000001
|
| 9 |
+
D25K:D79F:E74K:I92D:Q77G:S31P:S42G:S48P:T76P,DVSGTVCLSALPPEATDTLNLIASKGPFPYPQDGVVFQNREGVLPTQPYGYYHEYTVITPGARTRGTRRIITGKAPGEFYYTGDHYATFSLDDQTC,-4.65
|
| 10 |
+
D25K:D79F:E74K:Q77G:S31P:S42G:S48P:T76P,DVSGTVCLSALPPEATDTLNLIASKGPFPYPQDGVVFQNREGVLPTQPYGYYHEYTVITPGARTRGTRRIITGKAPGEFYYTGDHYATFSLIDQTC,7.0
|
| 11 |
+
D25K:D79F:E74K:Q77G:S31P:S42G:S48P:T76P:Y80A,DVSGTVCLSALPPEATDTLNLIASKGPFPYPQDGVVFQNREGVLPTQPYGYYHEYTVITPGARTRGTRRIITGKAPGEFAYTGDHYATFSLIDQTC,-2.35
|
| 12 |
+
D25K:E74K,DVSGTVCLSALPPEATDTLNLIASKGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGKATQEDYYTGDHYATFSLIDQTC,0.6333333333333333
|
| 13 |
+
D25K:E74K:I92D:Q77G:S31P:S42G:S48P:T76P,DVSGTVCLSALPPEATDTLNLIASKGPFPYPQDGVVFQNREGVLPTQPYGYYHEYTVITPGARTRGTRRIITGKAPGEDYYTGDHYATFSLDDQTC,-7.35
|
| 14 |
+
D25K:E74K:Q77G:S31P:S42G:S48P:T76P,DVSGTVCLSALPPEATDTLNLIASKGPFPYPQDGVVFQNREGVLPTQPYGYYHEYTVITPGARTRGTRRIITGKAPGEDYYTGDHYATFSLIDQTC,4.6
|
| 15 |
+
R40E:R63E,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNEESVLPTQSYGYYHEYTVITPGAETRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,0.25
|
| 16 |
+
R40E:R63E:R65A,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNEESVLPTQSYGYYHEYTVITPGAETAGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-1.15
|
| 17 |
+
R40E:R63E:R65A:R68A:R69A,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNEESVLPTQSYGYYHEYTVITPGAETAGTAAIITGEATQEDYYTGDHYATFSLIDQTC,0.1
|
mutant/stability/M1261_1LRP_A_ddG.csv
CHANGED
|
@@ -1,20 +1,20 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A15G:G46A:G48A,-0.55
|
| 3 |
-
A20G:G46A:G48A,0.87
|
| 4 |
-
A37G:G46A:G48A,0.62
|
| 5 |
-
A49G:G46A:G48A,1.25
|
| 6 |
-
A63G:G46A:G48A,1.49
|
| 7 |
-
A66G:G46A:G48A,0.07
|
| 8 |
-
A81G:G46A:G48A,0.77
|
| 9 |
-
G46A:G48A,1.638
|
| 10 |
-
G46A:G48A:P78A,0.2
|
| 11 |
-
G46A:G48A:Y88C,4.2
|
| 12 |
-
L65F:M40F:V36F:V47I,-1.65
|
| 13 |
-
M40F:V36F:V47F,-3.05
|
| 14 |
-
M40F:V36F:V47I,-2.2
|
| 15 |
-
M40L:V36F,-1.4
|
| 16 |
-
M40L:V36L:V47I,0.2
|
| 17 |
-
M40V:V36I:V47I,-0.8
|
| 18 |
-
M40V:V36I:V47L,-0.9
|
| 19 |
-
M40V:V36L:V47I,-1.1
|
| 20 |
-
M40V:V47L,-1.1
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A15G:G46A:G48A,STKKKPLTQEQLEDGRRLKAIYEKKKNELGLSQESVADKMGMGQSAVAALFNGINALNAYNAALLAKILKVSVEEFSPSIAREIYEMYEAVS,-0.55
|
| 3 |
+
A20G:G46A:G48A,STKKKPLTQEQLEDARRLKGIYEKKKNELGLSQESVADKMGMGQSAVAALFNGINALNAYNAALLAKILKVSVEEFSPSIAREIYEMYEAVS,0.87
|
| 4 |
+
A37G:G46A:G48A,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESVGDKMGMGQSAVAALFNGINALNAYNAALLAKILKVSVEEFSPSIAREIYEMYEAVS,0.62
|
| 5 |
+
A49G:G46A:G48A,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESVADKMGMGQSAVAGLFNGINALNAYNAALLAKILKVSVEEFSPSIAREIYEMYEAVS,1.25
|
| 6 |
+
A63G:G46A:G48A,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESVADKMGMGQSAVAALFNGINALNAYNAGLLAKILKVSVEEFSPSIAREIYEMYEAVS,1.49
|
| 7 |
+
A66G:G46A:G48A,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESVADKMGMGQSAVAALFNGINALNAYNAALLGKILKVSVEEFSPSIAREIYEMYEAVS,0.07
|
| 8 |
+
A81G:G46A:G48A,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESVADKMGMGQSAVAALFNGINALNAYNAALLAKILKVSVEEFSPSIGREIYEMYEAVS,0.77
|
| 9 |
+
G46A:G48A,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESVADKMGMGQSAVAALFNGINALNAYNAALLAKILKVSVEEFSPSIAREIYEMYEAVS,1.638
|
| 10 |
+
G46A:G48A:P78A,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESVADKMGMGQSAVAALFNGINALNAYNAALLAKILKVSVEEFSASIAREIYEMYEAVS,0.2
|
| 11 |
+
G46A:G48A:Y88C,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESVADKMGMGQSAVAALFNGINALNAYNAALLAKILKVSVEEFSPSIAREIYEMCEAVS,4.2
|
| 12 |
+
L65F:M40F:V36F:V47I,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESFADKFGMGQSGIGALFNGINALNAYNAALFAKILKVSVEEFSPSIAREIYEMYEAVS,-1.65
|
| 13 |
+
M40F:V36F:V47F,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESFADKFGMGQSGFGALFNGINALNAYNAALLAKILKVSVEEFSPSIAREIYEMYEAVS,-3.05
|
| 14 |
+
M40F:V36F:V47I,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESFADKFGMGQSGIGALFNGINALNAYNAALLAKILKVSVEEFSPSIAREIYEMYEAVS,-2.2
|
| 15 |
+
M40L:V36F,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESFADKLGMGQSGVGALFNGINALNAYNAALLAKILKVSVEEFSPSIAREIYEMYEAVS,-1.4
|
| 16 |
+
M40L:V36L:V47I,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESLADKLGMGQSGIGALFNGINALNAYNAALLAKILKVSVEEFSPSIAREIYEMYEAVS,0.2
|
| 17 |
+
M40V:V36I:V47I,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESIADKVGMGQSGIGALFNGINALNAYNAALLAKILKVSVEEFSPSIAREIYEMYEAVS,-0.8
|
| 18 |
+
M40V:V36I:V47L,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESIADKVGMGQSGLGALFNGINALNAYNAALLAKILKVSVEEFSPSIAREIYEMYEAVS,-0.9
|
| 19 |
+
M40V:V36L:V47I,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESLADKVGMGQSGIGALFNGINALNAYNAALLAKILKVSVEEFSPSIAREIYEMYEAVS,-1.1
|
| 20 |
+
M40V:V47L,STKKKPLTQEQLEDARRLKAIYEKKKNELGLSQESVADKVGMGQSGLGALFNGINALNAYNAALLAKILKVSVEEFSPSIAREIYEMYEAVS,-1.1
|
mutant/stability/M1261_1RN1_C_ddG.csv
CHANGED
|
@@ -1,9 +1,9 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A21G:G23A,-2.2
|
| 3 |
-
C10A:C2A,-2.79
|
| 4 |
-
E58A:Q25K,-0.0112499999999999
|
| 5 |
-
H40T:W59Y,-0.9315
|
| 6 |
-
H92A:W59Y,-1.5286
|
| 7 |
-
P55N:S54G,-0.9
|
| 8 |
-
W59Y:Y24W,0.2866
|
| 9 |
-
W59Y:Y42W,-1.027
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A21G:G23A,ACDYTCGSNCYSSSDVSTAQGAAYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-2.2
|
| 3 |
+
C10A:C2A,AADYTCGSNAYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-2.79
|
| 4 |
+
E58A:Q25K,ACDYTCGSNCYSSSDVSTAQAAGYKLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYAWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-0.0112499999999999
|
| 5 |
+
H40T:W59Y,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPTKYNNYEGFDFSVSSPYYEYPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-0.9315
|
| 6 |
+
H92A:W59Y,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEYPILSSGDVYSGGSPGADRVVFNENNQLAGVITATGASGNNFVECT,-1.5286
|
| 7 |
+
P55N:S54G,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSGNYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-0.9
|
| 8 |
+
W59Y:Y24W,ACDYTCGSNCYSSSDVSTAQAAGWQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEYPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,0.2866
|
| 9 |
+
W59Y:Y42W,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKWNNYEGFDFSVSSPYYEYPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-1.027
|
mutant/stability/M1261_1RTB_A_ddG.csv
CHANGED
|
@@ -1,10 +1,10 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A122C:I107C,-2.35287375
|
| 3 |
-
A4C:D83E:V118C,3.821536
|
| 4 |
-
A4C:V118C,1.6237233333333332
|
| 5 |
-
C40A:C95A,-4.55
|
| 6 |
-
H105C:V124C,-0.17927875
|
| 7 |
-
M30C:N44C,-5.039651
|
| 8 |
-
P114G:P93A,-4.2
|
| 9 |
-
R10C:R33C,-2.03136425
|
| 10 |
-
R85C:V43C,0.8829417500000001
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A122C:I107C,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHICVACEGNPYVPVHFDCSV,-2.35287375
|
| 3 |
+
A4C:D83E:V118C,KETCAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITECRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPCHFDASV,3.821536
|
| 4 |
+
A4C:V118C,KETCAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPCHFDASV,1.6237233333333332
|
| 5 |
+
C40A:C95A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRAKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNAAYKTTQANKHIIVACEGNPYVPVHFDASV,-4.55
|
| 6 |
+
H105C:V124C,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKCIIVACEGNPYVPVHFDASC,-0.17927875
|
| 7 |
+
M30C:N44C,KETAAAKFERQHMDSSTSAASSSNYCNQMCKSRNLTKDRCKPVCTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-5.039651
|
| 8 |
+
P114G:P93A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYANCAYKTTQANKHIIVACEGNGYVPVHFDASV,-4.2
|
| 9 |
+
R10C:R33C,KETAAAKFECQHMDSSTSAASSSNYCNQMMKSCNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-2.03136425
|
| 10 |
+
R85C:V43C,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPCNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCCETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,0.8829417500000001
|
mutant/stability/M1261_1SHG_A_ddG.csv
CHANGED
|
@@ -1,28 +1,28 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A11I:M25I:V23I:V44I:V53I:V58I:V9I,-1.5
|
| 3 |
-
A11V:L31I:L33I:M25I:V23L:V44L:V53F:V58L:V9L,-3.1
|
| 4 |
-
A11V:L33I:M25I:V23L:V44I:V53I:V58I:V9L,-2.4
|
| 5 |
-
A11V:L33I:M25I:V23L:V53I:V58I:V9L,-2.5
|
| 6 |
-
A11V:M25I:V23L:V44I:V53I:V58I:V9I,-2.0
|
| 7 |
-
A11V:M25I:V23L:V44I:V58L,0.2
|
| 8 |
-
A11V:M25I:V23L:V53F:V58L:V9I,-2.6
|
| 9 |
-
A11V:M25I:V23L:V53I:V58L,-0.1
|
| 10 |
-
A11V:M25I:V23L:V58L,2.0
|
| 11 |
-
A11V:M25I:V44I:V58L,0.5
|
| 12 |
-
A11V:M25I:V58L,2.2
|
| 13 |
-
A11V:M25L:V23L:V44A:V53F:V58L,-3.3
|
| 14 |
-
A11V:M25L:V23L:V53L:V58L:V9L,-2.8
|
| 15 |
-
A11V:M25V:V23L:V44I:V58L,0.962764125
|
| 16 |
-
A11V:M25V:V23L:V53I:V58L,1.7000000000000002
|
| 17 |
-
A11V:M25V:V44I:V58L,1.5
|
| 18 |
-
F52Y:K18Y:K27Y:K59Y,-4.75
|
| 19 |
-
F52Y:K18Y:K59Y,0.0
|
| 20 |
-
K18F:K59F:Y13F,0.0
|
| 21 |
-
K18F:K59F:Y13F:Y57F,0.0
|
| 22 |
-
K18Y:K59F,-0.5823750000000001
|
| 23 |
-
K18Y:K59F:Y13F,0.002
|
| 24 |
-
K18Y:K59F:Y13F:Y57F,0.071
|
| 25 |
-
K18Y:K59F:Y57F,-1.6406666666666667
|
| 26 |
-
K59Y:Y57F,0.0
|
| 27 |
-
M25V:V23L:V44I:V58N:V9I,-4.1
|
| 28 |
-
Y13F:Y57F,-0.418375
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A11I:M25I:V23I:V44I:V53I:V58I:V9I,MDETGKELILILYDYQEKSPREITIKKGDILTLLNSTNKDWWKIEVNDRQGFIPAAYIKKLD,-1.5
|
| 3 |
+
A11V:L31I:L33I:M25I:V23L:V44L:V53F:V58L:V9L,MDETGKELLLVLYDYQEKSPRELTIKKGDIITILNSTNKDWWKLEVNDRQGFFPAAYLKKLD,-3.1
|
| 4 |
+
A11V:L33I:M25I:V23L:V44I:V53I:V58I:V9L,MDETGKELLLVLYDYQEKSPRELTIKKGDILTILNSTNKDWWKIEVNDRQGFIPAAYIKKLD,-2.4
|
| 5 |
+
A11V:L33I:M25I:V23L:V53I:V58I:V9L,MDETGKELLLVLYDYQEKSPRELTIKKGDILTILNSTNKDWWKVEVNDRQGFIPAAYIKKLD,-2.5
|
| 6 |
+
A11V:M25I:V23L:V44I:V53I:V58I:V9I,MDETGKELILVLYDYQEKSPRELTIKKGDILTLLNSTNKDWWKIEVNDRQGFIPAAYIKKLD,-2.0
|
| 7 |
+
A11V:M25I:V23L:V44I:V58L,MDETGKELVLVLYDYQEKSPRELTIKKGDILTLLNSTNKDWWKIEVNDRQGFVPAAYLKKLD,0.2
|
| 8 |
+
A11V:M25I:V23L:V53F:V58L:V9I,MDETGKELILVLYDYQEKSPRELTIKKGDILTLLNSTNKDWWKVEVNDRQGFFPAAYLKKLD,-2.6
|
| 9 |
+
A11V:M25I:V23L:V53I:V58L,MDETGKELVLVLYDYQEKSPRELTIKKGDILTLLNSTNKDWWKVEVNDRQGFIPAAYLKKLD,-0.1
|
| 10 |
+
A11V:M25I:V23L:V58L,MDETGKELVLVLYDYQEKSPRELTIKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYLKKLD,2.0
|
| 11 |
+
A11V:M25I:V44I:V58L,MDETGKELVLVLYDYQEKSPREVTIKKGDILTLLNSTNKDWWKIEVNDRQGFVPAAYLKKLD,0.5
|
| 12 |
+
A11V:M25I:V58L,MDETGKELVLVLYDYQEKSPREVTIKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYLKKLD,2.2
|
| 13 |
+
A11V:M25L:V23L:V44A:V53F:V58L,MDETGKELVLVLYDYQEKSPRELTLKKGDILTLLNSTNKDWWKAEVNDRQGFFPAAYLKKLD,-3.3
|
| 14 |
+
A11V:M25L:V23L:V53L:V58L:V9L,MDETGKELLLVLYDYQEKSPRELTLKKGDILTLLNSTNKDWWKVEVNDRQGFLPAAYLKKLD,-2.8
|
| 15 |
+
A11V:M25V:V23L:V44I:V58L,MDETGKELVLVLYDYQEKSPRELTVKKGDILTLLNSTNKDWWKIEVNDRQGFVPAAYLKKLD,0.962764125
|
| 16 |
+
A11V:M25V:V23L:V53I:V58L,MDETGKELVLVLYDYQEKSPRELTVKKGDILTLLNSTNKDWWKVEVNDRQGFIPAAYLKKLD,1.7000000000000002
|
| 17 |
+
A11V:M25V:V44I:V58L,MDETGKELVLVLYDYQEKSPREVTVKKGDILTLLNSTNKDWWKIEVNDRQGFVPAAYLKKLD,1.5
|
| 18 |
+
F52Y:K18Y:K27Y:K59Y,MDETGKELVLALYDYQEYSPREVTMKYGDILTLLNSTNKDWWKVEVNDRQGYVPAAYVYKLD,-4.75
|
| 19 |
+
F52Y:K18Y:K59Y,MDETGKELVLALYDYQEYSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGYVPAAYVYKLD,0.0
|
| 20 |
+
K18F:K59F:Y13F,MDETGKELVLALFDYQEFSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVFKLD,0.0
|
| 21 |
+
K18F:K59F:Y13F:Y57F,MDETGKELVLALFDYQEFSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAFVFKLD,0.0
|
| 22 |
+
K18Y:K59F,MDETGKELVLALYDYQEYSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVFKLD,-0.5823750000000001
|
| 23 |
+
K18Y:K59F:Y13F,MDETGKELVLALFDYQEYSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVFKLD,0.002
|
| 24 |
+
K18Y:K59F:Y13F:Y57F,MDETGKELVLALFDYQEYSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAFVFKLD,0.071
|
| 25 |
+
K18Y:K59F:Y57F,MDETGKELVLALYDYQEYSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAFVFKLD,-1.6406666666666667
|
| 26 |
+
K59Y:Y57F,MDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAFVYKLD,0.0
|
| 27 |
+
M25V:V23L:V44I:V58N:V9I,MDETGKELILALYDYQEKSPRELTVKKGDILTLLNSTNKDWWKIEVNDRQGFVPAAYNKKLD,-4.1
|
| 28 |
+
Y13F:Y57F,MDETGKELVLALFDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAFVKKLD,-0.418375
|
mutant/stability/M1261_2AFG_A_ddG.csv
CHANGED
|
@@ -1,29 +1,29 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
C117S:C83S,-1.9143005
|
| 3 |
-
C117V:C83I:K12V,-1.361422
|
| 4 |
-
C117V:C83T,-0.4759805
|
| 5 |
-
C117V:C83T:F132W:L44F,-0.0022308
|
| 6 |
-
C117V:K12V,1.8032875
|
| 7 |
-
C16S:H93G,-0.974788
|
| 8 |
-
F108Y:H102Y,0.5804999999999996
|
| 9 |
-
F108Y:H102Y:H21Y,1.0834999999999997
|
| 10 |
-
F108Y:H102Y:H21Y:H93G:L44F:Q40P:S47I,7.4
|
| 11 |
-
F108Y:H102Y:H21Y:L44F:Q40P:S47I,5.4
|
| 12 |
-
F108Y:H102Y:H21Y:L44F:S47I,4.0
|
| 13 |
-
F108Y:H102Y:L44F,0.9475
|
| 14 |
-
F108Y:H21Y,0.7145
|
| 15 |
-
F108Y:H21Y:L44F,1.2105
|
| 16 |
-
F108Y:L44F,0.6705000000000001
|
| 17 |
-
F132W:L44F,0.979269
|
| 18 |
-
F132W:L44W,0.0007494999999999
|
| 19 |
-
H102Y:H21Y,0.733
|
| 20 |
-
H102Y:H21Y:L44F,1.193
|
| 21 |
-
H102Y:H21Y:L44F:Q40P,3.5
|
| 22 |
-
H102Y:L44F,0.683
|
| 23 |
-
H21Y:L44F,0.992
|
| 24 |
-
H93G:Q40P:S47I,5.85
|
| 25 |
-
L44F:Q40P,2.1
|
| 26 |
-
L44F:Q40P:S47I,4.25
|
| 27 |
-
L44F:S47I,2.55
|
| 28 |
-
L44P:L73V:V109L,-0.143308
|
| 29 |
-
L73V:V109L,-0.883729999999999
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
C117S:C83S,FNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEESLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSSKRGPRTHYGQKAILFLPLPVSSD,-1.9143005
|
| 3 |
+
C117V:C83I:K12V,FNLPPGNYKKPVLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEEILFLERLEENHYNTYISKKHAEKNWFVGLKKNGSVKRGPRTHYGQKAILFLPLPVSSD,-1.361422
|
| 4 |
+
C117V:C83T,FNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEETLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSVKRGPRTHYGQKAILFLPLPVSSD,-0.4759805
|
| 5 |
+
C117V:C83T:F132W:L44F,FNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQFQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEETLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSVKRGPRTHYGQKAILWLPLPVSSD,-0.0022308
|
| 6 |
+
C117V:K12V,FNLPPGNYKKPVLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSVKRGPRTHYGQKAILFLPLPVSSD,1.8032875
|
| 7 |
+
C16S:H93G,FNLPPGNYKKPKLLYSSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENGYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,-0.974788
|
| 8 |
+
F108Y:H102Y,FNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKYAEKNWYVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,0.5804999999999996
|
| 9 |
+
F108Y:H102Y:H21Y,FNLPPGNYKKPKLLYCSNGGYFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKYAEKNWYVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,1.0834999999999997
|
| 10 |
+
F108Y:H102Y:H21Y:H93G:L44F:Q40P:S47I,FNLPPGNYKKPKLLYCSNGGYFLRILPDGTVDGTRDRSDPHIQFQLIAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENGYNTYISKKYAEKNWYVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,7.4
|
| 11 |
+
F108Y:H102Y:H21Y:L44F:Q40P:S47I,FNLPPGNYKKPKLLYCSNGGYFLRILPDGTVDGTRDRSDPHIQFQLIAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKYAEKNWYVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,5.4
|
| 12 |
+
F108Y:H102Y:H21Y:L44F:S47I,FNLPPGNYKKPKLLYCSNGGYFLRILPDGTVDGTRDRSDQHIQFQLIAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKYAEKNWYVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,4.0
|
| 13 |
+
F108Y:H102Y:L44F,FNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQFQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKYAEKNWYVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,0.9475
|
| 14 |
+
F108Y:H21Y,FNLPPGNYKKPKLLYCSNGGYFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWYVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,0.7145
|
| 15 |
+
F108Y:H21Y:L44F,FNLPPGNYKKPKLLYCSNGGYFLRILPDGTVDGTRDRSDQHIQFQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWYVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,1.2105
|
| 16 |
+
F108Y:L44F,FNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQFQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWYVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,0.6705000000000001
|
| 17 |
+
F132W:L44F,FNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQFQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILWLPLPVSSD,0.979269
|
| 18 |
+
F132W:L44W,FNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQWQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILWLPLPVSSD,0.0007494999999999
|
| 19 |
+
H102Y:H21Y,FNLPPGNYKKPKLLYCSNGGYFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKYAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,0.733
|
| 20 |
+
H102Y:H21Y:L44F,FNLPPGNYKKPKLLYCSNGGYFLRILPDGTVDGTRDRSDQHIQFQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKYAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,1.193
|
| 21 |
+
H102Y:H21Y:L44F:Q40P,FNLPPGNYKKPKLLYCSNGGYFLRILPDGTVDGTRDRSDPHIQFQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKYAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,3.5
|
| 22 |
+
H102Y:L44F,FNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQFQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKYAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,0.683
|
| 23 |
+
H21Y:L44F,FNLPPGNYKKPKLLYCSNGGYFLRILPDGTVDGTRDRSDQHIQFQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,0.992
|
| 24 |
+
H93G:Q40P:S47I,FNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDPHIQLQLIAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENGYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,5.85
|
| 25 |
+
L44F:Q40P,FNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDPHIQFQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,2.1
|
| 26 |
+
L44F:Q40P:S47I,FNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDPHIQFQLIAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,4.25
|
| 27 |
+
L44F:S47I,FNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQFQLIAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,2.55
|
| 28 |
+
L44P:L73V:V109L,FNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQPQLSAESVGEVYIKSTETGQYLAMDTDGLVYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFLGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,-0.143308
|
| 29 |
+
L73V:V109L,FNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLVYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFLGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD,-0.883729999999999
|
mutant/stability/M1261_2CI2_I_ddG.csv
CHANGED
|
@@ -1,6 +1,6 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
E33A:E34A,-0.6411111111111111
|
| 3 |
-
E33A:E34A:S31A,-1.458888888888889
|
| 4 |
-
E33A:E34A:S31G,-1.3250000000000002
|
| 5 |
-
E45A:K43A,-0.835
|
| 6 |
-
I48A:I76V,-4.407500000000001
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
E33A:E34A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVAAAKKVILQDKPEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-0.6411111111111111
|
| 3 |
+
E33A:E34A:S31A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKAVAAAKKVILQDKPEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-1.458888888888889
|
| 4 |
+
E33A:E34A:S31G,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKGVAAAKKVILQDKPEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-1.3250000000000002
|
| 5 |
+
E45A:K43A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDAPAAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-0.835
|
| 6 |
+
I48A:I76V,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKPEAQAIVLPVGTIVTMEYRIDRVRLFVDKLDNVAEVPRVG,-4.407500000000001
|
mutant/stability/M1261_2H6X_A_ddG.csv
CHANGED
|
@@ -1,7 +1,7 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
C32A:C35A:T66L:T77V,-6.2
|
| 3 |
-
C32S:C35S,3.1
|
| 4 |
-
C32S:C35S:L78C,0.81
|
| 5 |
-
K90C:L78C,-2.3
|
| 6 |
-
L79C:T89C,2.1
|
| 7 |
-
T77C:V91C,1.7833333333333334
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
C32A:C35A:T66L:T77V,SDKIIHLTDDSFDTDVLKADGAILVDFWAEWAGPAKMIAPILDEIADEYQGKLTVAKLNIDQNPGLAPKYGIRGIPVLLLFKNGEVAATKVGALSKGQLKEFLDANLA,-6.2
|
| 3 |
+
C32S:C35S,SDKIIHLTDDSFDTDVLKADGAILVDFWAEWSGPSKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFKNGEVAATKVGALSKGQLKEFLDANLA,3.1
|
| 4 |
+
C32S:C35S:L78C,SDKIIHLTDDSFDTDVLKADGAILVDFWAEWSGPSKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTCLLFKNGEVAATKVGALSKGQLKEFLDANLA,0.81
|
| 5 |
+
K90C:L78C,SDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTCLLFKNGEVAATCVGALSKGQLKEFLDANLA,-2.3
|
| 6 |
+
L79C:T89C,SDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLCLFKNGEVAACKVGALSKGQLKEFLDANLA,2.1
|
| 7 |
+
T77C:V91C,SDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPCLLLFKNGEVAATKCGALSKGQLKEFLDANLA,1.7833333333333334
|
mutant/stability/M1261_2LZM_A_ddG.csv
CHANGED
|
@@ -1,85 +1,85 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A112D:K83H,-1.3333333333333333
|
| 3 |
-
A129L:F153L:L121A:L133A,-3.5
|
| 4 |
-
A129L:F153W:L121I:L133M,-1.3
|
| 5 |
-
A129L:F153W:L121M:L133M:V149I,-1.3
|
| 6 |
-
A129L:L121A,-1.1
|
| 7 |
-
A129M:F153A,-4.3
|
| 8 |
-
A129M:F153L:L121A,-1.1
|
| 9 |
-
A129M:L121A,-1.0
|
| 10 |
-
A129M:L121A:V149I,-1.4
|
| 11 |
-
A129V:F153L:L121A:L133M,-2.3
|
| 12 |
-
A129W:L121I:L133M,-1.4
|
| 13 |
-
A41V:A82P:I3L:N116D:N144D:S38D:V131A,3.245
|
| 14 |
-
A41V:A82P:I3L:N144D:S38D:V131A,2.745
|
| 15 |
-
A41V:V131A,0.645
|
| 16 |
-
A82P:I3L:N144D:S38D,2.135
|
| 17 |
-
A82P:I3L:N144D:S38D:V131A,2.41
|
| 18 |
-
A82P:N144D:S38D,1.32
|
| 19 |
-
A98V:T152S,-5.15
|
| 20 |
-
A98V:T152S:V149C,-4.4
|
| 21 |
-
A98V:T152S:V149I,-4.4
|
| 22 |
-
C54T:C97A,-0.3966666666666666
|
| 23 |
-
C54V:C97S,-2.1
|
| 24 |
-
D127A:D47A:E128A:E45A:K48A:N132A:N40A:S44A:V131A,1.75
|
| 25 |
-
D127A:E128A,0.24
|
| 26 |
-
D127A:E128A:K135A:N132A:N140A:Q141A:R137A:S136A:V131A:Y139A,-0.5
|
| 27 |
-
D127A:E128A:K135A:N132A:S136A:V131A,-0.5
|
| 28 |
-
D127A:E128A:L133A:N132A:V131A,-2.385
|
| 29 |
-
D127A:E128A:N132A:V131A,0.93
|
| 30 |
-
D70N:H31N,-4.0
|
| 31 |
-
D89A:R96H,-4.05
|
| 32 |
-
E108V:L32A:L33A:T34A,-3.0
|
| 33 |
-
E108V:L99A,-3.2
|
| 34 |
-
E108V:L99G,-5.9
|
| 35 |
-
E128A:K135A:N132A:N140A:Q141A:R137A:S136A:V131A:Y139A,-0.5
|
| 36 |
-
E128A:K135A:N132A:R137A:S136A:V131A,-0.5
|
| 37 |
-
E128A:K35A:N132A:P37A:S36A:T34A:V131A,-0.2
|
| 38 |
-
E128A:L133A:N132A:V131A,-2.545
|
| 39 |
-
E128A:N132A:N53A:N55A:V131A:V57A,-0.8
|
| 40 |
-
E128A:N132A:V131A,0.9125
|
| 41 |
-
E22A:I17A:K16A:K19A:R14A:T21A,-3.0
|
| 42 |
-
E45A:K48A,0.195
|
| 43 |
-
F153A:L99A,-7.6
|
| 44 |
-
F153L:L121M:L133V,-2.5
|
| 45 |
-
F153L:L99F,0.12
|
| 46 |
-
F153L:L99F:M102L,-0.215
|
| 47 |
-
F153L:L99F:M102L:V111I,-0.595
|
| 48 |
-
F153L:L99F:V111I,-0.49
|
| 49 |
-
F153L:V111I,-1.09
|
| 50 |
-
G28A:G30A:I29A,-5.5
|
| 51 |
-
I27A:T26A:Y24A:Y25A,-5.5
|
| 52 |
-
K135E:K147E,0.9
|
| 53 |
-
K135E:K147E:K16E,1.25
|
| 54 |
-
K135E:K147E:K16E:R119E,0.95
|
| 55 |
-
K135E:K147E:R119E,0.95
|
| 56 |
-
K135E:K16E,0.8
|
| 57 |
-
K135E:R119E,0.8
|
| 58 |
-
K147M:N144E,0.4000000000000001
|
| 59 |
-
K16E:R119E,0.08
|
| 60 |
-
K16E:R154E,0.35
|
| 61 |
-
K35A:P37A:S36A:T34A,-0.7000000000000001
|
| 62 |
-
K60H:L13D,-2.3666666666666667
|
| 63 |
-
K85A:R96H,-3.55
|
| 64 |
-
L118A:L121A,1.0
|
| 65 |
-
L99F:M102L,-0.73
|
| 66 |
-
L99F:M102L:V111I,-1.1749999999999998
|
| 67 |
-
L99F:V111I,-0.875
|
| 68 |
-
M102L:V111F,-1.81
|
| 69 |
-
M120A:N116A,0.21
|
| 70 |
-
M120A:Q122A,-0.25
|
| 71 |
-
M6I:R96H,-5.08
|
| 72 |
-
N116D:R119M,-0.15
|
| 73 |
-
N132I:S117A,2.0
|
| 74 |
-
N132I:S117I,1.4
|
| 75 |
-
N132M:S117A,1.8
|
| 76 |
-
N132M:S117I,2.0
|
| 77 |
-
N144D:S38D,0.8150000000000001
|
| 78 |
-
N53A:N55A:V57A,-1.5
|
| 79 |
-
Q122D:S90H,-1.7333333333333334
|
| 80 |
-
Q123A:R119A,-0.17
|
| 81 |
-
R119A:S117A,1.16
|
| 82 |
-
R119A:T115A,-0.17
|
| 83 |
-
R119H:R80K,-0.47
|
| 84 |
-
S117A:T115A,0.95
|
| 85 |
-
W126Y:W138Y:W158Y,-2.3975
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A112D:K83H,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAHLKPVYDSLDAVRRCALINMVFQMGETGVDGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-1.3333333333333333
|
| 3 |
+
A129L:F153L:L121A:L133A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMAQQKRWDELAVNAAKSRWYNQTPNRAKRVITTLRTGTWDAYKNL,-3.5
|
| 4 |
+
A129L:F153W:L121I:L133M,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMIQQKRWDELAVNMAKSRWYNQTPNRAKRVITTWRTGTWDAYKNL,-1.3
|
| 5 |
+
A129L:F153W:L121M:L133M:V149I,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMMQQKRWDELAVNMAKSRWYNQTPNRAKRIITTWRTGTWDAYKNL,-1.3
|
| 6 |
+
A129L:L121A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMAQQKRWDELAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-1.1
|
| 7 |
+
A129M:F153A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEMAVNLAKSRWYNQTPNRAKRVITTARTGTWDAYKNL,-4.3
|
| 8 |
+
A129M:F153L:L121A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMAQQKRWDEMAVNLAKSRWYNQTPNRAKRVITTLRTGTWDAYKNL,-1.1
|
| 9 |
+
A129M:L121A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMAQQKRWDEMAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-1.0
|
| 10 |
+
A129M:L121A:V149I,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMAQQKRWDEMAVNLAKSRWYNQTPNRAKRIITTFRTGTWDAYKNL,-1.4
|
| 11 |
+
A129V:F153L:L121A:L133M,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMAQQKRWDEVAVNMAKSRWYNQTPNRAKRVITTLRTGTWDAYKNL,-2.3
|
| 12 |
+
A129W:L121I:L133M,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMIQQKRWDEWAVNMAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-1.4
|
| 13 |
+
A41V:A82P:I3L:N116D:N144D:S38D:V131A,MNLFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPDLNVAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNPKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTDSLRMLQQKRWDEAAANLAKSRWYNQTPDRAKRVITTFRTGTWDAYKNL,3.245
|
| 14 |
+
A41V:A82P:I3L:N144D:S38D:V131A,MNLFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPDLNVAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNPKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAANLAKSRWYNQTPDRAKRVITTFRTGTWDAYKNL,2.745
|
| 15 |
+
A41V:V131A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNVAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAANLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,0.645
|
| 16 |
+
A82P:I3L:N144D:S38D,MNLFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPDLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNPKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPDRAKRVITTFRTGTWDAYKNL,2.135
|
| 17 |
+
A82P:I3L:N144D:S38D:V131A,MNLFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPDLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNPKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAANLAKSRWYNQTPDRAKRVITTFRTGTWDAYKNL,2.41
|
| 18 |
+
A82P:N144D:S38D,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPDLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNPKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPDRAKRVITTFRTGTWDAYKNL,1.32
|
| 19 |
+
A98V:T152S,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCVLINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITSFRTGTWDAYKNL,-5.15
|
| 20 |
+
A98V:T152S:V149C,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCVLINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRCITSFRTGTWDAYKNL,-4.4
|
| 21 |
+
A98V:T152S:V149I,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCVLINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRIITSFRTGTWDAYKNL,-4.4
|
| 22 |
+
C54T:C97A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-0.3966666666666666
|
| 23 |
+
C54V:C97S,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNVNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRSALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-2.1
|
| 24 |
+
D127A:D47A:E128A:E45A:K48A:N132A:N40A:S44A:V131A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLAAAKAALAAAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWAAAAAALAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,1.75
|
| 25 |
+
D127A:E128A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWAAAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,0.24
|
| 26 |
+
D127A:E128A:K135A:N132A:N140A:Q141A:R137A:S136A:V131A:Y139A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWAAAAAALAAAAWAAATPNRAKRVITTFRTGTWDAYKNL,-0.5
|
| 27 |
+
D127A:E128A:K135A:N132A:S136A:V131A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWAAAAAALAAARWYNQTPNRAKRVITTFRTGTWDAYKNL,-0.5
|
| 28 |
+
D127A:E128A:L133A:N132A:V131A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWAAAAAAAAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-2.385
|
| 29 |
+
D127A:E128A:N132A:V131A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWAAAAAALAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,0.93
|
| 30 |
+
D70N:H31N,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGNLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQNVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-4.0
|
| 31 |
+
D89A:R96H,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYASLDAVRHCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-4.05
|
| 32 |
+
E108V:L32A:L33A:T34A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHAAAKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGVTGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-3.0
|
| 33 |
+
E108V:L99A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCAAINMVFQMGVTGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-3.2
|
| 34 |
+
E108V:L99G,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCAGINMVFQMGVTGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-5.9
|
| 35 |
+
E128A:K135A:N132A:N140A:Q141A:R137A:S136A:V131A:Y139A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDAAAAALAAAAWAAATPNRAKRVITTFRTGTWDAYKNL,-0.5
|
| 36 |
+
E128A:K135A:N132A:R137A:S136A:V131A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDAAAAALAAAAWYNQTPNRAKRVITTFRTGTWDAYKNL,-0.5
|
| 37 |
+
E128A:K35A:N132A:P37A:S36A:T34A:V131A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLAAAASLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDAAAAALAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-0.2
|
| 38 |
+
E128A:L133A:N132A:V131A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDAAAAAAAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-2.545
|
| 39 |
+
E128A:N132A:N53A:N55A:V131A:V57A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRACAGAITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDAAAAALAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-0.8
|
| 40 |
+
E128A:N132A:V131A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDAAAAALAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,0.9125
|
| 41 |
+
E22A:I17A:K16A:K19A:R14A:T21A,MNIFEMLRIDEGLALAAYADAAGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-3.0
|
| 42 |
+
E45A:K48A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSALDAAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,0.195
|
| 43 |
+
F153A:L99A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCAAINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTARTGTWDAYKNL,-7.6
|
| 44 |
+
F153L:L121M:L133V,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMMQQKRWDEAAVNVAKSRWYNQTPNRAKRVITTLRTGTWDAYKNL,-2.5
|
| 45 |
+
F153L:L99F,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCAFINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTLRTGTWDAYKNL,0.12
|
| 46 |
+
F153L:L99F:M102L,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCAFINLVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTLRTGTWDAYKNL,-0.215
|
| 47 |
+
F153L:L99F:M102L:V111I,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCAFINLVFQMGETGIAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTLRTGTWDAYKNL,-0.595
|
| 48 |
+
F153L:L99F:V111I,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCAFINMVFQMGETGIAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTLRTGTWDAYKNL,-0.49
|
| 49 |
+
F153L:V111I,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGIAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTLRTGTWDAYKNL,-1.09
|
| 50 |
+
G28A:G30A:I29A,MNIFEMLRIDEGLRLKIYKDTEGYYTIAAAHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-5.5
|
| 51 |
+
I27A:T26A:Y24A:Y25A,MNIFEMLRIDEGLRLKIYKDTEGAAAAGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-5.5
|
| 52 |
+
K135E:K147E,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAESRWYNQTPNRAERVITTFRTGTWDAYKNL,0.9
|
| 53 |
+
K135E:K147E:K16E,MNIFEMLRIDEGLRLEIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAESRWYNQTPNRAERVITTFRTGTWDAYKNL,1.25
|
| 54 |
+
K135E:K147E:K16E:R119E,MNIFEMLRIDEGLRLEIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLEMLQQKRWDEAAVNLAESRWYNQTPNRAERVITTFRTGTWDAYKNL,0.95
|
| 55 |
+
K135E:K147E:R119E,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLEMLQQKRWDEAAVNLAESRWYNQTPNRAERVITTFRTGTWDAYKNL,0.95
|
| 56 |
+
K135E:K16E,MNIFEMLRIDEGLRLEIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAESRWYNQTPNRAKRVITTFRTGTWDAYKNL,0.8
|
| 57 |
+
K135E:R119E,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLEMLQQKRWDEAAVNLAESRWYNQTPNRAKRVITTFRTGTWDAYKNL,0.8
|
| 58 |
+
K147M:N144E,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPERAMRVITTFRTGTWDAYKNL,0.4000000000000001
|
| 59 |
+
K16E:R119E,MNIFEMLRIDEGLRLEIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLEMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,0.08
|
| 60 |
+
K16E:R154E,MNIFEMLRIDEGLRLEIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFETGTWDAYKNL,0.35
|
| 61 |
+
K35A:P37A:S36A:T34A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLAAAASLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-0.7000000000000001
|
| 62 |
+
K60H:L13D,MNIFEMLRIDEGDRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITHDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-2.3666666666666667
|
| 63 |
+
K85A:R96H,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLAPVYDSLDAVRHCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-3.55
|
| 64 |
+
L118A:L121A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSARMAQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,1.0
|
| 65 |
+
L99F:M102L,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCAFINLVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-0.73
|
| 66 |
+
L99F:M102L:V111I,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCAFINLVFQMGETGIAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-1.1749999999999998
|
| 67 |
+
L99F:V111I,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCAFINMVFQMGETGIAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-0.875
|
| 68 |
+
M102L:V111F,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINLVFQMGETGFAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-1.81
|
| 69 |
+
M120A:N116A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTASLRALQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,0.21
|
| 70 |
+
M120A:Q122A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRALAQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-0.25
|
| 71 |
+
M6I:R96H,MNIFEILRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRHCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-5.08
|
| 72 |
+
N116D:R119M,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTDSLMMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-0.15
|
| 73 |
+
N132I:S117A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNALRMLQQKRWDEAAVILAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,2.0
|
| 74 |
+
N132I:S117I,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNILRMLQQKRWDEAAVILAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,1.4
|
| 75 |
+
N132M:S117A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNALRMLQQKRWDEAAVMLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,1.8
|
| 76 |
+
N132M:S117I,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNILRMLQQKRWDEAAVMLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,2.0
|
| 77 |
+
N144D:S38D,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPDLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPDRAKRVITTFRTGTWDAYKNL,0.8150000000000001
|
| 78 |
+
N53A:N55A:V57A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRACAGAITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-1.5
|
| 79 |
+
Q122D:S90H,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDHLDAVRRCALINMVFQMGETGVAGFTNSLRMLDQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-1.7333333333333334
|
| 80 |
+
Q123A:R119A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLAMLQAKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-0.17
|
| 81 |
+
R119A:S117A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNALAMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,1.16
|
| 82 |
+
R119A:T115A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFANSLAMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-0.17
|
| 83 |
+
R119H:R80K,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILKNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLHMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,-0.47
|
| 84 |
+
S117A:T115A,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFANALRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKNL,0.95
|
| 85 |
+
W126Y:W138Y:W158Y,MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQKRYDEAAVNLAKSRYYNQTPNRAKRVITTFRTGTYDAYKNL,-2.3975
|
mutant/stability/M1261_2RN2_A_ddG.csv
CHANGED
|
@@ -1,19 +1,19 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A52F:V74A,-1.4
|
| 3 |
-
A52F:V74L,0.03
|
| 4 |
-
A52G:V74L,-1.4
|
| 5 |
-
A52I:V74A,1.19
|
| 6 |
-
A52I:V74L,1.19
|
| 7 |
-
A52L:V74A,0.36
|
| 8 |
-
A52L:V74L,1.49
|
| 9 |
-
A52V:V74A,-0.52
|
| 10 |
-
A52V:V74L,2.43
|
| 11 |
-
D94E:K91R,-0.55
|
| 12 |
-
D94E:K91R:K95G,-0.9033333333333332
|
| 13 |
-
D94R:K95G,1.3
|
| 14 |
-
E119V:K60R,0.285
|
| 15 |
-
E119V:R41C,0.645
|
| 16 |
-
G30A:R29H:R31H:Y28F,0.8
|
| 17 |
-
H62P:K122R:T40A,0.175
|
| 18 |
-
K117R:Q80L,-0.03
|
| 19 |
-
K91R:K95G,1.6
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A52F:V74A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAFIVALEALKEHCEVILSTDSQYARQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-1.4
|
| 3 |
+
A52F:V74L,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAFIVALEALKEHCEVILSTDSQYLRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.03
|
| 4 |
+
A52G:V74L,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAGIVALEALKEHCEVILSTDSQYLRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-1.4
|
| 5 |
+
A52I:V74A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAIIVALEALKEHCEVILSTDSQYARQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,1.19
|
| 6 |
+
A52I:V74L,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAIIVALEALKEHCEVILSTDSQYLRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,1.19
|
| 7 |
+
A52L:V74A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMALIVALEALKEHCEVILSTDSQYARQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.36
|
| 8 |
+
A52L:V74L,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMALIVALEALKEHCEVILSTDSQYLRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,1.49
|
| 9 |
+
A52V:V74A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAVIVALEALKEHCEVILSTDSQYARQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-0.52
|
| 10 |
+
A52V:V74L,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAVIVALEALKEHCEVILSTDSQYLRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,2.43
|
| 11 |
+
D94E:K91R,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWRTAEKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-0.55
|
| 12 |
+
D94E:K91R:K95G,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWRTAEGKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-0.9033333333333332
|
| 13 |
+
D94R:K95G,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTARGKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,1.3
|
| 14 |
+
E119V:K60R,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALREHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWVWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.285
|
| 15 |
+
E119V:R41C,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTCTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWVWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.645
|
| 16 |
+
G30A:R29H:R31H:Y28F,MLKQVEIFTDGSCLGNPGPGGYGAILRFHAHEKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.8
|
| 17 |
+
H62P:K122R:T40A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYARTTNNRMELMAAIVALEALKEPCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVRGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.175
|
| 18 |
+
K117R:Q80L,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITLWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIRWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-0.03
|
| 19 |
+
K91R:K95G,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWRTADGKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,1.6
|
mutant/stability/M1261_451C_A_ddG.csv
CHANGED
|
@@ -1,10 +1,10 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
E43Y:F34Y,1.7793578125
|
| 3 |
-
E43Y:F34Y:F7A:V13M,3.0563160000000003
|
| 4 |
-
E43Y:F34Y:F7A:V13M:V78I,4.632894125
|
| 5 |
-
E43Y:F34Y:Q37R,2.0
|
| 6 |
-
E43Y:F34Y:V78I,2.262715
|
| 7 |
-
E43Y:Q37R,0.5
|
| 8 |
-
F34Y:Q37R,1.5
|
| 9 |
-
F7A:V13M,1.729546625
|
| 10 |
-
F7A:V13M:V78I,2.266559833333333
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
E43Y:F34Y,EDPEVLFKNKGCVACHAIDTKMVGPAYKDVAAKYAGQAGAEAYLAQRIKNGSQGVWGPIPMPPNAVSDDEAQTLAKWVLSQK,1.7793578125
|
| 3 |
+
E43Y:F34Y:F7A:V13M,EDPEVLAKNKGCMACHAIDTKMVGPAYKDVAAKYAGQAGAEAYLAQRIKNGSQGVWGPIPMPPNAVSDDEAQTLAKWVLSQK,3.0563160000000003
|
| 4 |
+
E43Y:F34Y:F7A:V13M:V78I,EDPEVLAKNKGCMACHAIDTKMVGPAYKDVAAKYAGQAGAEAYLAQRIKNGSQGVWGPIPMPPNAVSDDEAQTLAKWILSQK,4.632894125
|
| 5 |
+
E43Y:F34Y:Q37R,EDPEVLFKNKGCVACHAIDTKMVGPAYKDVAAKYAGRAGAEAYLAQRIKNGSQGVWGPIPMPPNAVSDDEAQTLAKWVLSQK,2.0
|
| 6 |
+
E43Y:F34Y:V78I,EDPEVLFKNKGCVACHAIDTKMVGPAYKDVAAKYAGQAGAEAYLAQRIKNGSQGVWGPIPMPPNAVSDDEAQTLAKWILSQK,2.262715
|
| 7 |
+
E43Y:Q37R,EDPEVLFKNKGCVACHAIDTKMVGPAYKDVAAKFAGRAGAEAYLAQRIKNGSQGVWGPIPMPPNAVSDDEAQTLAKWVLSQK,0.5
|
| 8 |
+
F34Y:Q37R,EDPEVLFKNKGCVACHAIDTKMVGPAYKDVAAKYAGRAGAEAELAQRIKNGSQGVWGPIPMPPNAVSDDEAQTLAKWVLSQK,1.5
|
| 9 |
+
F7A:V13M,EDPEVLAKNKGCMACHAIDTKMVGPAYKDVAAKFAGQAGAEAELAQRIKNGSQGVWGPIPMPPNAVSDDEAQTLAKWVLSQK,1.729546625
|
| 10 |
+
F7A:V13M:V78I,EDPEVLAKNKGCMACHAIDTKMVGPAYKDVAAKFAGQAGAEAELAQRIKNGSQGVWGPIPMPPNAVSDDEAQTLAKWILSQK,2.266559833333333
|
mutant/stability/M1261_5PTI_A_ddG.csv
CHANGED
|
@@ -1,8 +1,8 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
C14A:C38A,0.0
|
| 3 |
-
C30A:C51A,-4.62
|
| 4 |
-
C30A:C51S,-8.93
|
| 5 |
-
C30G:C51A,-5.95
|
| 6 |
-
C30S:C51A,-8.0
|
| 7 |
-
C30T:C51A,-4.904999999999999
|
| 8 |
-
C30V:C51A,-6.14
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
C14A:C38A,RPDFCLEPPYTGPAKARIIRYFYNAKAGLCQTFVYGGARAKRNNFKSAEDCMRTCGGA,0.0
|
| 3 |
+
C30A:C51A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLAQTFVYGGCRAKRNNFKSAEDAMRTCGGA,-4.62
|
| 4 |
+
C30A:C51S,RPDFCLEPPYTGPCKARIIRYFYNAKAGLAQTFVYGGCRAKRNNFKSAEDSMRTCGGA,-8.93
|
| 5 |
+
C30G:C51A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLGQTFVYGGCRAKRNNFKSAEDAMRTCGGA,-5.95
|
| 6 |
+
C30S:C51A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLSQTFVYGGCRAKRNNFKSAEDAMRTCGGA,-8.0
|
| 7 |
+
C30T:C51A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLTQTFVYGGCRAKRNNFKSAEDAMRTCGGA,-4.904999999999999
|
| 8 |
+
C30V:C51A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLVQTFVYGGCRAKRNNFKSAEDAMRTCGGA,-6.14
|
mutant/stability/S4346_1AKY_dTm.csv
CHANGED
|
@@ -1,7 +1,7 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
I213F,-7.7
|
| 3 |
-
N169D,-0.6
|
| 4 |
-
Q48E,-1.3
|
| 5 |
-
T110H,-6.15
|
| 6 |
-
T77H,-1.0
|
| 7 |
-
V8I,-1.5
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
I213F,SSESIRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPACKNGFILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADFLNKLGKN,-7.7
|
| 3 |
+
N169D,SSESIRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPACKNGFILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQRSDDDADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLGKN,-0.6
|
| 4 |
+
Q48E,SSESIRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTELGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPACKNGFILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLGKN,-1.3
|
| 5 |
+
T110H,SSESIRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPACKNGFILDGFPRTIPQAEKLDQMLKEQGHPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLGKN,-6.15
|
| 6 |
+
T77H,SSESIRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELHNNPACKNGFILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLGKN,-1.0
|
| 7 |
+
V8I,SSESIRMILIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPACKNGFILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLGKN,-1.5
|
mutant/stability/S4346_1BNI_dTm.csv
CHANGED
|
@@ -1,44 +1,44 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
D12A,-1.0
|
| 3 |
-
D12G,-2.15
|
| 4 |
-
D22M,-1.6
|
| 5 |
-
D54N,-7.3
|
| 6 |
-
D8A,-1.955
|
| 7 |
-
D8G,-3.0
|
| 8 |
-
E73G,-12.7
|
| 9 |
-
G52A,-13.3
|
| 10 |
-
G52V,-21.1
|
| 11 |
-
G53A,-8.6
|
| 12 |
-
G53V,-19.6
|
| 13 |
-
H18N,-4.1
|
| 14 |
-
I4A,-3.3
|
| 15 |
-
I51V,-4.5
|
| 16 |
-
I55G,-5.3
|
| 17 |
-
I88A,-11.2
|
| 18 |
-
I88G,-20.8
|
| 19 |
-
I88V,-3.135
|
| 20 |
-
I96A,-9.0
|
| 21 |
-
I96G,-15.7
|
| 22 |
-
I96V,-2.3466666666666667
|
| 23 |
-
L14A,-11.9
|
| 24 |
-
L89G,-8.7
|
| 25 |
-
L95G,-9.1
|
| 26 |
-
N41A,-8.2
|
| 27 |
-
N58A,-4.5
|
| 28 |
-
Q15A,-0.9
|
| 29 |
-
Q15G,-2.0
|
| 30 |
-
R69M,-5.8
|
| 31 |
-
R72G,-5.7
|
| 32 |
-
R83Q,-3.3
|
| 33 |
-
S91A,-4.75
|
| 34 |
-
S92A,-6.95
|
| 35 |
-
T100G,-4.3
|
| 36 |
-
T105V,-5.1
|
| 37 |
-
T16R,1.3
|
| 38 |
-
T26G,-4.1
|
| 39 |
-
T6G,-3.3
|
| 40 |
-
V36A,-2.8
|
| 41 |
-
Y13G,-15.6
|
| 42 |
-
Y17A,-5.1
|
| 43 |
-
Y17G,-10.3
|
| 44 |
-
Y97G,-17.9
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
D12A,AQVINTFDGVAAYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-1.0
|
| 3 |
+
D12G,AQVINTFDGVAGYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-2.15
|
| 4 |
+
D22M,AQVINTFDGVADYLQTYHKLPMNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-1.6
|
| 5 |
+
D54N,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGNIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-7.3
|
| 6 |
+
D8A,AQVINTFAGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-1.955
|
| 7 |
+
D8G,AQVINTFGGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-3.0
|
| 8 |
+
E73G,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWRGADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-12.7
|
| 9 |
+
G52A,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIAGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-13.3
|
| 10 |
+
G52V,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIVGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-21.1
|
| 11 |
+
G53A,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGADIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-8.6
|
| 12 |
+
G53V,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGVDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-19.6
|
| 13 |
+
H18N,AQVINTFDGVADYLQTYNKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-4.1
|
| 14 |
+
I4A,AQVANTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-3.3
|
| 15 |
+
I51V,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSVGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-4.5
|
| 16 |
+
I55G,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDGFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-5.3
|
| 17 |
+
I88A,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRALYSSDWLIYKTTDHYQTFTKIR,-11.2
|
| 18 |
+
I88G,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRGLYSSDWLIYKTTDHYQTFTKIR,-20.8
|
| 19 |
+
I88V,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRVLYSSDWLIYKTTDHYQTFTKIR,-3.135
|
| 20 |
+
I96A,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLAYKTTDHYQTFTKIR,-9.0
|
| 21 |
+
I96G,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLGYKTTDHYQTFTKIR,-15.7
|
| 22 |
+
I96V,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLVYKTTDHYQTFTKIR,-2.3466666666666667
|
| 23 |
+
L14A,AQVINTFDGVADYAQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-11.9
|
| 24 |
+
L89G,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRIGYSSDWLIYKTTDHYQTFTKIR,-8.7
|
| 25 |
+
L95G,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWGIYKTTDHYQTFTKIR,-9.1
|
| 26 |
+
N41A,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGALADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-8.2
|
| 27 |
+
N58A,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSAREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-4.5
|
| 28 |
+
Q15A,AQVINTFDGVADYLATYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-0.9
|
| 29 |
+
Q15G,AQVINTFDGVADYLGTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-2.0
|
| 30 |
+
R69M,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGMTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-5.8
|
| 31 |
+
R72G,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWGEADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-5.7
|
| 32 |
+
R83Q,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFQNSDRILYSSDWLIYKTTDHYQTFTKIR,-3.3
|
| 33 |
+
S91A,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYASDWLIYKTTDHYQTFTKIR,-4.75
|
| 34 |
+
S92A,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSADWLIYKTTDHYQTFTKIR,-6.95
|
| 35 |
+
T100G,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTGDHYQTFTKIR,-4.3
|
| 36 |
+
T105V,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQVFTKIR,-5.1
|
| 37 |
+
T16R,AQVINTFDGVADYLQRYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,1.3
|
| 38 |
+
T26G,AQVINTFDGVADYLQTYHKLPDNYIGKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-4.1
|
| 39 |
+
T6G,AQVINGFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-3.3
|
| 40 |
+
V36A,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWAASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-2.8
|
| 41 |
+
Y13G,AQVINTFDGVADGLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-15.6
|
| 42 |
+
Y17A,AQVINTFDGVADYLQTAHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-5.1
|
| 43 |
+
Y17G,AQVINTFDGVADYLQTGHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIYKTTDHYQTFTKIR,-10.3
|
| 44 |
+
Y97G,AQVINTFDGVADYLQTYHKLPDNYITKSEAQALGWVASKGNLADVAPGKSIGGDIFSNREGKLPGKSGRTWREADINYTSGFRNSDRILYSSDWLIGKTTDHYQTFTKIR,-17.9
|
mutant/stability/S4346_1BVC_dTm.csv
CHANGED
|
@@ -1,38 +1,38 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
G129A,2.0
|
| 3 |
-
G23A,-2.2
|
| 4 |
-
H116A,0.3
|
| 5 |
-
I111A,-6.4
|
| 6 |
-
I111L,-2.0
|
| 7 |
-
I111M,-3.7
|
| 8 |
-
I142A,-3.7
|
| 9 |
-
I142L,1.8
|
| 10 |
-
I142M,2.6
|
| 11 |
-
I142V,-0.3
|
| 12 |
-
I28A,-4.4
|
| 13 |
-
I28L,-1.7
|
| 14 |
-
I28M,-1.7
|
| 15 |
-
I28V,0.1
|
| 16 |
-
L11A,-0.8
|
| 17 |
-
L135I,-5.2
|
| 18 |
-
L135M,-2.5
|
| 19 |
-
L135V,-8.3
|
| 20 |
-
L137A,-3.6
|
| 21 |
-
L149A,-3.2
|
| 22 |
-
L29A,-8.9
|
| 23 |
-
L29I,-3.6
|
| 24 |
-
L29M,0.3
|
| 25 |
-
L29V,-6.0
|
| 26 |
-
L49I,-2.5
|
| 27 |
-
L69A,-3.8
|
| 28 |
-
L69I,-0.1
|
| 29 |
-
L69M,0.0
|
| 30 |
-
L69V,-0.3
|
| 31 |
-
L9A,-0.8
|
| 32 |
-
P88A,1.1
|
| 33 |
-
S117A,-0.5
|
| 34 |
-
T51A,-2.8
|
| 35 |
-
T67A,-0.5
|
| 36 |
-
V114A,-2.9
|
| 37 |
-
V13A,-1.3
|
| 38 |
-
V66A,1.4
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
G129A,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQAAMNKALELFRKDIAAKYKELGYQG,2.0
|
| 3 |
+
G23A,VLSEGEWQLVLHVWAKVEADVAAHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-2.2
|
| 4 |
+
H116A,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLASRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,0.3
|
| 5 |
+
I111A,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAAIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-6.4
|
| 6 |
+
I111L,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEALIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-2.0
|
| 7 |
+
I111M,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAMIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-3.7
|
| 8 |
+
I142A,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDAAAKYKELGYQG,-3.7
|
| 9 |
+
I142L,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDLAAKYKELGYQG,1.8
|
| 10 |
+
I142M,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDMAAKYKELGYQG,2.6
|
| 11 |
+
I142V,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDVAAKYKELGYQG,-0.3
|
| 12 |
+
I28A,VLSEGEWQLVLHVWAKVEADVAGHGQDALIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-4.4
|
| 13 |
+
I28L,VLSEGEWQLVLHVWAKVEADVAGHGQDLLIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-1.7
|
| 14 |
+
I28M,VLSEGEWQLVLHVWAKVEADVAGHGQDMLIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-1.7
|
| 15 |
+
I28V,VLSEGEWQLVLHVWAKVEADVAGHGQDVLIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,0.1
|
| 16 |
+
L11A,VLSEGEWQLVAHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-0.8
|
| 17 |
+
L135I,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKAIELFRKDIAAKYKELGYQG,-5.2
|
| 18 |
+
L135M,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKAMELFRKDIAAKYKELGYQG,-2.5
|
| 19 |
+
L135V,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKAVELFRKDIAAKYKELGYQG,-8.3
|
| 20 |
+
L137A,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALEAFRKDIAAKYKELGYQG,-3.6
|
| 21 |
+
L149A,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKEAGYQG,-3.2
|
| 22 |
+
L29A,VLSEGEWQLVLHVWAKVEADVAGHGQDIAIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-8.9
|
| 23 |
+
L29I,VLSEGEWQLVLHVWAKVEADVAGHGQDIIIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-3.6
|
| 24 |
+
L29M,VLSEGEWQLVLHVWAKVEADVAGHGQDIMIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,0.3
|
| 25 |
+
L29V,VLSEGEWQLVLHVWAKVEADVAGHGQDIVIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-6.0
|
| 26 |
+
L49I,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHIKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-2.5
|
| 27 |
+
L69A,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVATALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-3.8
|
| 28 |
+
L69I,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVITALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-0.1
|
| 29 |
+
L69M,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVMTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,0.0
|
| 30 |
+
L69V,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVVTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-0.3
|
| 31 |
+
L9A,VLSEGEWQAVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-0.8
|
| 32 |
+
P88A,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKALAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,1.1
|
| 33 |
+
S117A,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHARHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-0.5
|
| 34 |
+
T51A,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKAEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-2.8
|
| 35 |
+
T67A,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVAVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-0.5
|
| 36 |
+
V114A,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHALHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-2.9
|
| 37 |
+
V13A,VLSEGEWQLVLHAWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,-1.3
|
| 38 |
+
V66A,VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGATVLTALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKYKELGYQG,1.4
|
mutant/stability/S4346_1EY0_dTm.csv
CHANGED
|
@@ -1,145 +1,145 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A112C,-2.8
|
| 3 |
-
A112F,-6.7
|
| 4 |
-
A60C,-3.6
|
| 5 |
-
A69T,-13.6
|
| 6 |
-
A90S,-12.1
|
| 7 |
-
D19F,-4.6
|
| 8 |
-
D21K,7.9
|
| 9 |
-
D21N,7.2
|
| 10 |
-
D77A,-10.7
|
| 11 |
-
D77G,-8.1
|
| 12 |
-
E101F,-14.2
|
| 13 |
-
E122F,-0.6
|
| 14 |
-
E135F,-3.5
|
| 15 |
-
E52F,-0.3
|
| 16 |
-
E57C,-0.9
|
| 17 |
-
E57F,-0.9
|
| 18 |
-
E57G,-1.7
|
| 19 |
-
E67F,-5.8
|
| 20 |
-
E73F,-4.8
|
| 21 |
-
E73G,-15.2
|
| 22 |
-
E75A,-5.6
|
| 23 |
-
E75G,-16.1
|
| 24 |
-
E75V,-6.6
|
| 25 |
-
F34C,8.25
|
| 26 |
-
G29C,-4.6
|
| 27 |
-
G29F,-5.9
|
| 28 |
-
G50C,-2.6
|
| 29 |
-
G50F,-2.5
|
| 30 |
-
G79S,-8.45
|
| 31 |
-
G86F,-8.8
|
| 32 |
-
G88V,3.25
|
| 33 |
-
G88W,4.666666666666666
|
| 34 |
-
G96F,-11.0
|
| 35 |
-
H124L,5.51
|
| 36 |
-
H46Y,-0.6
|
| 37 |
-
I18M,-2.1
|
| 38 |
-
K116F,0.4
|
| 39 |
-
K116G,3.8
|
| 40 |
-
K127F,-0.9
|
| 41 |
-
K134C,-2.9
|
| 42 |
-
K134F,-1.7
|
| 43 |
-
K136F,-5.95
|
| 44 |
-
K24G,-6.2
|
| 45 |
-
K28F,-4.2
|
| 46 |
-
K48F,0.0
|
| 47 |
-
K49F,-1.0
|
| 48 |
-
K70C,-2.8
|
| 49 |
-
K70F,0.0
|
| 50 |
-
K70W,-3.4
|
| 51 |
-
K78C,0.4
|
| 52 |
-
K78F,-0.5
|
| 53 |
-
K84F,-3.0
|
| 54 |
-
L137A,-8.7
|
| 55 |
-
L25A,-13.65
|
| 56 |
-
L36C,7.25
|
| 57 |
-
L7A,-3.2
|
| 58 |
-
L89F,-7.5
|
| 59 |
-
M32I,-2.3
|
| 60 |
-
M32L,-3.2
|
| 61 |
-
M65F,-5.8
|
| 62 |
-
P117G,5.0
|
| 63 |
-
P117T,0.6
|
| 64 |
-
P47F,-0.6
|
| 65 |
-
Q123F,-1.3
|
| 66 |
-
Q80F,-1.5
|
| 67 |
-
R105C,-11.1
|
| 68 |
-
R105F,-15.1
|
| 69 |
-
S128A,4.0
|
| 70 |
-
S128F,-3.6
|
| 71 |
-
S141A,-0.8333333333333334
|
| 72 |
-
S59A,2.9
|
| 73 |
-
T120C,-5.5
|
| 74 |
-
T120I,-4.8
|
| 75 |
-
T120S,-2.0
|
| 76 |
-
T120V,-5.1
|
| 77 |
-
T13C,-3.4
|
| 78 |
-
T13S,-1.1
|
| 79 |
-
T13V,-1.1
|
| 80 |
-
T22C,-2.8
|
| 81 |
-
T22I,-3.3
|
| 82 |
-
T22S,-2.2
|
| 83 |
-
T22V,-2.7
|
| 84 |
-
T33C,-3.0
|
| 85 |
-
T33I,1.7
|
| 86 |
-
T33S,-4.8
|
| 87 |
-
T33V,1.8
|
| 88 |
-
T41C,2.1
|
| 89 |
-
T41I,4.0
|
| 90 |
-
T41S,-2.8
|
| 91 |
-
T41V,3.5
|
| 92 |
-
T44C,0.1
|
| 93 |
-
T44I,-3.8
|
| 94 |
-
T44S,-0.1
|
| 95 |
-
T44V,0.2
|
| 96 |
-
T62A,-7.6
|
| 97 |
-
T62C,-4.1
|
| 98 |
-
T62F,0.0
|
| 99 |
-
T62G,-15.9
|
| 100 |
-
T62H,-8.1
|
| 101 |
-
T62I,-2.7
|
| 102 |
-
T62K,-17.9
|
| 103 |
-
T62L,-4.9
|
| 104 |
-
T62M,-1.8
|
| 105 |
-
T62N,-16.3
|
| 106 |
-
T62Q,-12.9
|
| 107 |
-
T62S,-8.7
|
| 108 |
-
T62V,1.6
|
| 109 |
-
T82C,-1.9
|
| 110 |
-
T82I,1.2
|
| 111 |
-
T82S,-3.0
|
| 112 |
-
T82V,1.1
|
| 113 |
-
V104T,-9.9
|
| 114 |
-
V111T,-10.2
|
| 115 |
-
V114S,0.0
|
| 116 |
-
V114T,-0.4
|
| 117 |
-
V23A,-12.5
|
| 118 |
-
V23F,-8.25
|
| 119 |
-
V23T,-14.4
|
| 120 |
-
V39S,-10.8
|
| 121 |
-
V39T,-6.8
|
| 122 |
-
V51S,0.0
|
| 123 |
-
V51T,-0.3
|
| 124 |
-
V66A,-12.425
|
| 125 |
-
V66L,3.85
|
| 126 |
-
V66S,-13.4
|
| 127 |
-
V66T,-6.0
|
| 128 |
-
V66W,-7.8
|
| 129 |
-
V74T,-17.6
|
| 130 |
-
V99T,-14.6
|
| 131 |
-
W140F,-11.6
|
| 132 |
-
W140H,-8.9
|
| 133 |
-
W140Y,-12.1
|
| 134 |
-
Y113F,0.3
|
| 135 |
-
Y113L,-0.1
|
| 136 |
-
Y115F,0.2
|
| 137 |
-
Y115L,-0.6
|
| 138 |
-
Y27F,-3.0
|
| 139 |
-
Y54F,-1.0
|
| 140 |
-
Y54L,-12.2
|
| 141 |
-
Y85F,-0.5
|
| 142 |
-
Y85L,-0.7
|
| 143 |
-
Y91F,-6.8
|
| 144 |
-
Y91L,-13.9
|
| 145 |
-
Y93F,-7.2
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A112C,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVCYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.8
|
| 3 |
+
A112F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVFYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-6.7
|
| 4 |
+
A60C,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASCFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.6
|
| 5 |
+
A69T,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENTKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-13.6
|
| 6 |
+
A90S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLSYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-12.1
|
| 7 |
+
D19F,ATSTKKLHKEPATLIKAIFGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.6
|
| 8 |
+
D21K,ATSTKKLHKEPATLIKAIDGKTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,7.9
|
| 9 |
+
D21N,ATSTKKLHKEPATLIKAIDGNTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,7.2
|
| 10 |
+
D77A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFAKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-10.7
|
| 11 |
+
D77G,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFGKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-8.1
|
| 12 |
+
E101F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNFALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-14.2
|
| 13 |
+
E122F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHFQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.6
|
| 14 |
+
E135F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKFKLNIWSEDNADSGQ,-3.5
|
| 15 |
+
E52F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVFKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.3
|
| 16 |
+
E57C,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPCASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.9
|
| 17 |
+
E57F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPFASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.9
|
| 18 |
+
E57G,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPGASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.7
|
| 19 |
+
E67F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVFNAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-5.8
|
| 20 |
+
E73F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIFVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.8
|
| 21 |
+
E73G,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIGVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-15.2
|
| 22 |
+
E75A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVAFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-5.6
|
| 23 |
+
E75G,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVGFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-16.1
|
| 24 |
+
E75V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVVFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-6.6
|
| 25 |
+
F34C,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTCRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,8.25
|
| 26 |
+
G29C,ATSTKKLHKEPATLIKAIDGDTVKLMYKCQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.6
|
| 27 |
+
G29F,ATSTKKLHKEPATLIKAIDGDTVKLMYKFQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-5.9
|
| 28 |
+
G50C,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKCVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.6
|
| 29 |
+
G50F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKFVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.5
|
| 30 |
+
G79S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKSQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-8.45
|
| 31 |
+
G86F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYFRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-8.8
|
| 32 |
+
G88V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRVLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,3.25
|
| 33 |
+
G88W,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRWLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,4.666666666666666
|
| 34 |
+
G96F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADFKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-11.0
|
| 35 |
+
H124L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQLLRKSEAQAKKEKLNIWSEDNADSGQ,5.51
|
| 36 |
+
H46Y,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKYPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.6
|
| 37 |
+
I18M,ATSTKKLHKEPATLIKAMDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.1
|
| 38 |
+
K116F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYFPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,0.4
|
| 39 |
+
K116G,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYGPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,3.8
|
| 40 |
+
K127F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRFSEAQAKKEKLNIWSEDNADSGQ,-0.9
|
| 41 |
+
K134C,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKCEKLNIWSEDNADSGQ,-2.9
|
| 42 |
+
K134F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKFEKLNIWSEDNADSGQ,-1.7
|
| 43 |
+
K136F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEFLNIWSEDNADSGQ,-5.95
|
| 44 |
+
K24G,ATSTKKLHKEPATLIKAIDGDTVGLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-6.2
|
| 45 |
+
K28F,ATSTKKLHKEPATLIKAIDGDTVKLMYFGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.2
|
| 46 |
+
K48F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPFKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,0.0
|
| 47 |
+
K49F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKFGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.0
|
| 48 |
+
K70C,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENACKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.8
|
| 49 |
+
K70F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAFKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,0.0
|
| 50 |
+
K70W,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAWKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.4
|
| 51 |
+
K78C,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDCGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,0.4
|
| 52 |
+
K78F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDFGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.5
|
| 53 |
+
K84F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDFYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.0
|
| 54 |
+
L137A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKANIWSEDNADSGQ,-8.7
|
| 55 |
+
L25A,ATSTKKLHKEPATLIKAIDGDTVKAMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-13.65
|
| 56 |
+
L36C,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRCLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,7.25
|
| 57 |
+
L7A,ATSTKKAHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.2
|
| 58 |
+
L89F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGFAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-7.5
|
| 59 |
+
M32I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPITFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.3
|
| 60 |
+
M32L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPLTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.2
|
| 61 |
+
M65F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKFVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-5.8
|
| 62 |
+
P117G,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKGNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,5.0
|
| 63 |
+
P117T,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKTNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,0.6
|
| 64 |
+
P47F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHFKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.6
|
| 65 |
+
Q123F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEFHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.3
|
| 66 |
+
Q80F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGFRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.5
|
| 67 |
+
R105C,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVCQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-11.1
|
| 68 |
+
R105F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVFQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-15.1
|
| 69 |
+
S128A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKAEAQAKKEKLNIWSEDNADSGQ,4.0
|
| 70 |
+
S128F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKFEAQAKKEKLNIWSEDNADSGQ,-3.6
|
| 71 |
+
S141A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWAEDNADSGQ,-0.8333333333333334
|
| 72 |
+
S59A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEAAAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,2.9
|
| 73 |
+
T120C,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNCHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-5.5
|
| 74 |
+
T120I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNIHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.8
|
| 75 |
+
T120S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNSHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.0
|
| 76 |
+
T120V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNVHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-5.1
|
| 77 |
+
T13C,ATSTKKLHKEPACLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.4
|
| 78 |
+
T13S,ATSTKKLHKEPASLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.1
|
| 79 |
+
T13V,ATSTKKLHKEPAVLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.1
|
| 80 |
+
T22C,ATSTKKLHKEPATLIKAIDGDCVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.8
|
| 81 |
+
T22I,ATSTKKLHKEPATLIKAIDGDIVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.3
|
| 82 |
+
T22S,ATSTKKLHKEPATLIKAIDGDSVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.2
|
| 83 |
+
T22V,ATSTKKLHKEPATLIKAIDGDVVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.7
|
| 84 |
+
T33C,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMCFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.0
|
| 85 |
+
T33I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMIFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,1.7
|
| 86 |
+
T33S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMSFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.8
|
| 87 |
+
T33V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMVFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,1.8
|
| 88 |
+
T41C,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDCPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,2.1
|
| 89 |
+
T41I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDIPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,4.0
|
| 90 |
+
T41S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDSPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.8
|
| 91 |
+
T41V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDVPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,3.5
|
| 92 |
+
T44C,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPECKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,0.1
|
| 93 |
+
T44I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPEIKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.8
|
| 94 |
+
T44S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPESKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.1
|
| 95 |
+
T44V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPEVKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,0.2
|
| 96 |
+
T62A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFAKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-7.6
|
| 97 |
+
T62C,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFCKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.1
|
| 98 |
+
T62F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFFKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,0.0
|
| 99 |
+
T62G,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFGKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-15.9
|
| 100 |
+
T62H,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFHKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-8.1
|
| 101 |
+
T62I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFIKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-2.7
|
| 102 |
+
T62K,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFKKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-17.9
|
| 103 |
+
T62L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFLKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-4.9
|
| 104 |
+
T62M,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFMKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.8
|
| 105 |
+
T62N,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFNKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-16.3
|
| 106 |
+
T62Q,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFQKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-12.9
|
| 107 |
+
T62S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFSKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-8.7
|
| 108 |
+
T62V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFVKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,1.6
|
| 109 |
+
T82C,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRCDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.9
|
| 110 |
+
T82I,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRIDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,1.2
|
| 111 |
+
T82S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRSDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.0
|
| 112 |
+
T82V,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRVDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,1.1
|
| 113 |
+
V104T,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALTRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-9.9
|
| 114 |
+
V111T,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKTAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-10.2
|
| 115 |
+
V114S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYSYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,0.0
|
| 116 |
+
V114T,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYTYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.4
|
| 117 |
+
V23A,ATSTKKLHKEPATLIKAIDGDTAKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-12.5
|
| 118 |
+
V23F,ATSTKKLHKEPATLIKAIDGDTFKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-8.25
|
| 119 |
+
V23T,ATSTKKLHKEPATLIKAIDGDTTKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-14.4
|
| 120 |
+
V39S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLSDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-10.8
|
| 121 |
+
V39T,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLTDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-6.8
|
| 122 |
+
V51S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGSEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,0.0
|
| 123 |
+
V51T,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGTEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.3
|
| 124 |
+
V66A,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMAENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-12.425
|
| 125 |
+
V66L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMLENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,3.85
|
| 126 |
+
V66S,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMSENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-13.4
|
| 127 |
+
V66T,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMTENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-6.0
|
| 128 |
+
V66W,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMWENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-7.8
|
| 129 |
+
V74T,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIETEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-17.6
|
| 130 |
+
V99T,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMTNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-14.6
|
| 131 |
+
W140F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIFSEDNADSGQ,-11.6
|
| 132 |
+
W140H,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIHSEDNADSGQ,-8.9
|
| 133 |
+
W140Y,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIYSEDNADSGQ,-12.1
|
| 134 |
+
Y113F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAFVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,0.3
|
| 135 |
+
Y113L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVALVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.1
|
| 136 |
+
Y115F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVFKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,0.2
|
| 137 |
+
Y115L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVLKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.6
|
| 138 |
+
Y27F,ATSTKKLHKEPATLIKAIDGDTVKLMFKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-3.0
|
| 139 |
+
Y54F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKFGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-1.0
|
| 140 |
+
Y54L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKLGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-12.2
|
| 141 |
+
Y85F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKFGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.5
|
| 142 |
+
Y85L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKLGRGLAYIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-0.7
|
| 143 |
+
Y91F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAFIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-6.8
|
| 144 |
+
Y91L,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLALIYADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-13.9
|
| 145 |
+
Y93F,ATSTKKLHKEPATLIKAIDGDTVKLMYKGQPMTFRLLLVDTPETKHPKKGVEKYGPEASAFTKKMVENAKKIEVEFDKGQRTDKYGRGLAYIFADGKMVNEALVRQGLAKVAYVYKPNNTHEQHLRKSEAQAKKEKLNIWSEDNADSGQ,-7.2
|
mutant/stability/S4346_1HRC_dTm.csv
CHANGED
|
@@ -1,11 +1,11 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
H26V,-10.0
|
| 3 |
-
H33F,0.07
|
| 4 |
-
L94I,-3.8
|
| 5 |
-
L94V,-4.3
|
| 6 |
-
M80A,2.45
|
| 7 |
-
N52I,20.0
|
| 8 |
-
P30A,-9.0
|
| 9 |
-
P30V,-11.0
|
| 10 |
-
T49V,1.45
|
| 11 |
-
Y67F,30.0
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
H26V,GDVEKGKKIFVQKCAQCHTVEKGGKVKTGPNLHGLFGRKTGQAPGFTYTDANKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDLIAYLKKATNE,-10.0
|
| 3 |
+
H33F,GDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLFGLFGRKTGQAPGFTYTDANKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDLIAYLKKATNE,0.07
|
| 4 |
+
L94I,GDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFTYTDANKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDIIAYLKKATNE,-3.8
|
| 5 |
+
L94V,GDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFTYTDANKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDVIAYLKKATNE,-4.3
|
| 6 |
+
M80A,GDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFTYTDANKNKGITWKEETLMEYLENPKKYIPGTKAIFAGIKKKTEREDLIAYLKKATNE,2.45
|
| 7 |
+
N52I,GDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFTYTDAIKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDLIAYLKKATNE,20.0
|
| 8 |
+
P30A,GDVEKGKKIFVQKCAQCHTVEKGGKHKTGANLHGLFGRKTGQAPGFTYTDANKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDLIAYLKKATNE,-9.0
|
| 9 |
+
P30V,GDVEKGKKIFVQKCAQCHTVEKGGKHKTGVNLHGLFGRKTGQAPGFTYTDANKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDLIAYLKKATNE,-11.0
|
| 10 |
+
T49V,GDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFTYVDANKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDLIAYLKKATNE,1.45
|
| 11 |
+
Y67F,GDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFTYTDANKNKGITWKEETLMEFLENPKKYIPGTKMIFAGIKKKTEREDLIAYLKKATNE,30.0
|
mutant/stability/S4346_1KF2_dTm.csv
CHANGED
|
@@ -1,68 +1,68 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A109G,-2.6
|
| 3 |
-
A4S,-1.5
|
| 4 |
-
A5S,-1.1
|
| 5 |
-
A64G,-2.2
|
| 6 |
-
D38W,-3.5
|
| 7 |
-
F46A,0.0
|
| 8 |
-
F46E,-31.6
|
| 9 |
-
F46K,-34.3
|
| 10 |
-
F46L,-11.1
|
| 11 |
-
F46V,-11.9
|
| 12 |
-
F8W,-8.9
|
| 13 |
-
G88R,0.8
|
| 14 |
-
I106A,-14.9
|
| 15 |
-
I106L,-6.3
|
| 16 |
-
I106V,-3.0
|
| 17 |
-
I107A,-10.3
|
| 18 |
-
I107L,-8.6
|
| 19 |
-
I107V,0.6
|
| 20 |
-
I81A,-10.3
|
| 21 |
-
I81G,-17.0
|
| 22 |
-
I81V,-0.7
|
| 23 |
-
K104W,-10.9
|
| 24 |
-
K1W,3.3
|
| 25 |
-
N67D,-1.05
|
| 26 |
-
P114A,-10.55
|
| 27 |
-
P114G,-10.0
|
| 28 |
-
P117A,-6.7
|
| 29 |
-
P42A,-1.4
|
| 30 |
-
P93A,-10.1
|
| 31 |
-
P93G,-6.2
|
| 32 |
-
P93S,-8.5
|
| 33 |
-
S123A,1.4
|
| 34 |
-
S75A,-7.9
|
| 35 |
-
S75C,-17.9
|
| 36 |
-
S75R,-22.9
|
| 37 |
-
S75T,-8.9
|
| 38 |
-
V108A,-14.7
|
| 39 |
-
V108G,-27.133333333333336
|
| 40 |
-
V108I,0.1
|
| 41 |
-
V108L,-2.4
|
| 42 |
-
V116A,-3.2
|
| 43 |
-
V116G,-4.4
|
| 44 |
-
V118A,-5.5
|
| 45 |
-
V118G,-10.1
|
| 46 |
-
V124W,-4.5
|
| 47 |
-
V47A,-13.0
|
| 48 |
-
V47G,-26.8
|
| 49 |
-
V54A,-8.2
|
| 50 |
-
V54G,-17.2
|
| 51 |
-
V54I,-2.6
|
| 52 |
-
V54L,-3.3
|
| 53 |
-
V57A,-9.3
|
| 54 |
-
V57G,-19.9
|
| 55 |
-
V57I,-0.2
|
| 56 |
-
V57L,-7.3
|
| 57 |
-
V63A,0.1
|
| 58 |
-
V63G,-11.9
|
| 59 |
-
Y115W,-4.4
|
| 60 |
-
Y73W,-2.5
|
| 61 |
-
Y76W,-6.1
|
| 62 |
-
Y92A,-6.1
|
| 63 |
-
Y92G,-7.1
|
| 64 |
-
Y92L,-7.9
|
| 65 |
-
Y92W,1.1
|
| 66 |
-
Y97A,-34.3
|
| 67 |
-
Y97F,-10.1
|
| 68 |
-
Y97G,-33.3
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A109G,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVGCEGNPYVPVHFDASV,-2.6
|
| 3 |
+
A4S,KETSAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-1.5
|
| 4 |
+
A5S,KETASAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-1.1
|
| 5 |
+
A64G,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVGCKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-2.2
|
| 6 |
+
D38W,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKWRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-3.5
|
| 7 |
+
F46A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTAVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,0.0
|
| 8 |
+
F46E,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTEVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-31.6
|
| 9 |
+
F46K,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTKVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-34.3
|
| 10 |
+
F46L,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTLVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-11.1
|
| 11 |
+
F46V,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTVVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-11.9
|
| 12 |
+
F8W,KETAAAKWERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-8.9
|
| 13 |
+
G88R,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETRSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,0.8
|
| 14 |
+
I106A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHAIVACEGNPYVPVHFDASV,-14.9
|
| 15 |
+
I106L,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHLIVACEGNPYVPVHFDASV,-6.3
|
| 16 |
+
I106V,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHVIVACEGNPYVPVHFDASV,-3.0
|
| 17 |
+
I107A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIAVACEGNPYVPVHFDASV,-10.3
|
| 18 |
+
I107L,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHILVACEGNPYVPVHFDASV,-8.6
|
| 19 |
+
I107V,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIVVACEGNPYVPVHFDASV,0.6
|
| 20 |
+
I81A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSATDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-10.3
|
| 21 |
+
I81G,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSGTDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-17.0
|
| 22 |
+
I81V,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSVTDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-0.7
|
| 23 |
+
K104W,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANWHIIVACEGNPYVPVHFDASV,-10.9
|
| 24 |
+
K1W,WETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,3.3
|
| 25 |
+
N67D,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKDGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-1.05
|
| 26 |
+
P114A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNAYVPVHFDASV,-10.55
|
| 27 |
+
P114G,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNGYVPVHFDASV,-10.0
|
| 28 |
+
P117A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVAVHFDASV,-6.7
|
| 29 |
+
P42A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKAVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-1.4
|
| 30 |
+
P93A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYANCAYKTTQANKHIIVACEGNPYVPVHFDASV,-10.1
|
| 31 |
+
P93G,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYGNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-6.2
|
| 32 |
+
P93S,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYSNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-8.5
|
| 33 |
+
S123A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDAAV,1.4
|
| 34 |
+
S75A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQAYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-7.9
|
| 35 |
+
S75C,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQCYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-17.9
|
| 36 |
+
S75R,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQRYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-22.9
|
| 37 |
+
S75T,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQTYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-8.9
|
| 38 |
+
V108A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIAACEGNPYVPVHFDASV,-14.7
|
| 39 |
+
V108G,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIGACEGNPYVPVHFDASV,-27.133333333333336
|
| 40 |
+
V108I,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIIACEGNPYVPVHFDASV,0.1
|
| 41 |
+
V108L,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIILACEGNPYVPVHFDASV,-2.4
|
| 42 |
+
V116A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYAPVHFDASV,-3.2
|
| 43 |
+
V116G,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYGPVHFDASV,-4.4
|
| 44 |
+
V118A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPAHFDASV,-5.5
|
| 45 |
+
V118G,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPGHFDASV,-10.1
|
| 46 |
+
V124W,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASW,-4.5
|
| 47 |
+
V47A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFAHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-13.0
|
| 48 |
+
V47G,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFGHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-26.8
|
| 49 |
+
V54A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADAQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-8.2
|
| 50 |
+
V54G,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADGQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-17.2
|
| 51 |
+
V54I,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADIQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-2.6
|
| 52 |
+
V54L,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADLQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-3.3
|
| 53 |
+
V57A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAACSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-9.3
|
| 54 |
+
V57G,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAGCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-19.9
|
| 55 |
+
V57I,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAICSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-0.2
|
| 56 |
+
V57L,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQALCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-7.3
|
| 57 |
+
V63A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNAACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,0.1
|
| 58 |
+
V63G,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNGACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-11.9
|
| 59 |
+
Y115W,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPWVPVHFDASV,-4.4
|
| 60 |
+
Y73W,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCWQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-2.5
|
| 61 |
+
Y76W,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSWSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-6.1
|
| 62 |
+
Y92A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKAPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-6.1
|
| 63 |
+
Y92G,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKGPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-7.1
|
| 64 |
+
Y92L,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKLPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,-7.9
|
| 65 |
+
Y92W,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKWPNCAYKTTQANKHIIVACEGNPYVPVHFDASV,1.1
|
| 66 |
+
Y97A,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAAKTTQANKHIIVACEGNPYVPVHFDASV,-34.3
|
| 67 |
+
Y97F,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAFKTTQANKHIIVACEGNPYVPVHFDASV,-10.1
|
| 68 |
+
Y97G,KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAGKTTQANKHIIVACEGNPYVPVHFDASV,-33.3
|
mutant/stability/S4346_1LNI_dTm.csv
CHANGED
|
@@ -1,66 +1,66 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A23K,1.2
|
| 3 |
-
D25K,3.0
|
| 4 |
-
D33A,-16.0
|
| 5 |
-
D79A,6.533333333333332
|
| 6 |
-
D79E,-0.8
|
| 7 |
-
D79F,7.2
|
| 8 |
-
D79H,5.6
|
| 9 |
-
D79I,9.6
|
| 10 |
-
D79K,7.6
|
| 11 |
-
D79L,8.7
|
| 12 |
-
D79N,2.766666666666667
|
| 13 |
-
D79R,9.0
|
| 14 |
-
D79W,7.6
|
| 15 |
-
D79Y,9.6
|
| 16 |
-
E41K,-3.8
|
| 17 |
-
E54Q,-6.9
|
| 18 |
-
E74K,2.15
|
| 19 |
-
H85Q,0.0
|
| 20 |
-
I22K,-12.3
|
| 21 |
-
I22V,-5.7
|
| 22 |
-
I58V,0.11
|
| 23 |
-
I70V,-3.4
|
| 24 |
-
I71V,-0.3
|
| 25 |
-
I92V,-3.9
|
| 26 |
-
L11A,-11.9
|
| 27 |
-
L19A,-13.8
|
| 28 |
-
L19K,-12.3
|
| 29 |
-
L21A,-1.6
|
| 30 |
-
L8A,-5.0
|
| 31 |
-
L91A,-3.2
|
| 32 |
-
N20A,-0.1
|
| 33 |
-
N39A,-7.6
|
| 34 |
-
N39D,-4.95
|
| 35 |
-
N39S,-8.0
|
| 36 |
-
Q38A,2.4
|
| 37 |
-
Q94K,1.7666666666666668
|
| 38 |
-
R65A,-4.2
|
| 39 |
-
S24A,-0.7
|
| 40 |
-
S31A,1.5
|
| 41 |
-
S3A,-1.1
|
| 42 |
-
S42A,0.4
|
| 43 |
-
S48A,1.7
|
| 44 |
-
S90A,0.7
|
| 45 |
-
S9A,-4.5
|
| 46 |
-
T16V,1.0
|
| 47 |
-
T18V,-4.7
|
| 48 |
-
T56V,-6.3
|
| 49 |
-
T59V,-5.6
|
| 50 |
-
T5V,0.0
|
| 51 |
-
T67V,-0.1
|
| 52 |
-
T72V,-0.8
|
| 53 |
-
T82V,-5.7
|
| 54 |
-
T95A,-2.1
|
| 55 |
-
V2T,-3.2
|
| 56 |
-
V36T,-4.6
|
| 57 |
-
V43T,-1.6
|
| 58 |
-
V57T,-15.0
|
| 59 |
-
Y30F,1.2
|
| 60 |
-
Y49F,-0.8
|
| 61 |
-
Y51F,-7.6
|
| 62 |
-
Y52F,-12.1
|
| 63 |
-
Y55F,-1.9
|
| 64 |
-
Y80F,-5.2
|
| 65 |
-
Y81F,-3.9
|
| 66 |
-
Y86F,-1.1
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A23K,DVSGTVCLSALPPEATDTLNLIKSDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,1.2
|
| 3 |
+
D25K,DVSGTVCLSALPPEATDTLNLIASKGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,3.0
|
| 4 |
+
D33A,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQAGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-16.0
|
| 5 |
+
D79A,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEAYYTGDHYATFSLIDQTC,6.533333333333332
|
| 6 |
+
D79E,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEEYYTGDHYATFSLIDQTC,-0.8
|
| 7 |
+
D79F,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEFYYTGDHYATFSLIDQTC,7.2
|
| 8 |
+
D79H,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEHYYTGDHYATFSLIDQTC,5.6
|
| 9 |
+
D79I,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEIYYTGDHYATFSLIDQTC,9.6
|
| 10 |
+
D79K,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEKYYTGDHYATFSLIDQTC,7.6
|
| 11 |
+
D79L,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQELYYTGDHYATFSLIDQTC,8.7
|
| 12 |
+
D79N,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQENYYTGDHYATFSLIDQTC,2.766666666666667
|
| 13 |
+
D79R,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQERYYTGDHYATFSLIDQTC,9.0
|
| 14 |
+
D79W,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEWYYTGDHYATFSLIDQTC,7.6
|
| 15 |
+
D79Y,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEYYYTGDHYATFSLIDQTC,9.6
|
| 16 |
+
E41K,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRKSVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-3.8
|
| 17 |
+
E54Q,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHQYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-6.9
|
| 18 |
+
E74K,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGKATQEDYYTGDHYATFSLIDQTC,2.15
|
| 19 |
+
H85Q,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDQYATFSLIDQTC,0.0
|
| 20 |
+
I22K,DVSGTVCLSALPPEATDTLNLKASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-12.3
|
| 21 |
+
I22V,DVSGTVCLSALPPEATDTLNLVASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-5.7
|
| 22 |
+
I58V,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVVTPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,0.11
|
| 23 |
+
I70V,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRVITGEATQEDYYTGDHYATFSLIDQTC,-3.4
|
| 24 |
+
I71V,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIVTGEATQEDYYTGDHYATFSLIDQTC,-0.3
|
| 25 |
+
I92V,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLVDQTC,-3.9
|
| 26 |
+
L11A,DVSGTVCLSAAPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-11.9
|
| 27 |
+
L19A,DVSGTVCLSALPPEATDTANLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-13.8
|
| 28 |
+
L19K,DVSGTVCLSALPPEATDTKNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-12.3
|
| 29 |
+
L21A,DVSGTVCLSALPPEATDTLNAIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-1.6
|
| 30 |
+
L8A,DVSGTVCASALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-5.0
|
| 31 |
+
L91A,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSAIDQTC,-3.2
|
| 32 |
+
N20A,DVSGTVCLSALPPEATDTLALIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-0.1
|
| 33 |
+
N39A,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQARESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-7.6
|
| 34 |
+
N39D,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQDRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-4.95
|
| 35 |
+
N39S,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQSRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-8.0
|
| 36 |
+
Q38A,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFANRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,2.4
|
| 37 |
+
Q94K,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDKTC,1.7666666666666668
|
| 38 |
+
R65A,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTAGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-4.2
|
| 39 |
+
S24A,DVSGTVCLSALPPEATDTLNLIAADGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-0.7
|
| 40 |
+
S31A,DVSGTVCLSALPPEATDTLNLIASDGPFPYAQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,1.5
|
| 41 |
+
S3A,DVAGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-1.1
|
| 42 |
+
S42A,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNREAVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,0.4
|
| 43 |
+
S48A,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQAYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,1.7
|
| 44 |
+
S90A,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFALIDQTC,0.7
|
| 45 |
+
S9A,DVSGTVCLAALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-4.5
|
| 46 |
+
T16V,DVSGTVCLSALPPEAVDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,1.0
|
| 47 |
+
T18V,DVSGTVCLSALPPEATDVLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-4.7
|
| 48 |
+
T56V,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYVVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-6.3
|
| 49 |
+
T59V,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVIVPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-5.6
|
| 50 |
+
T5V,DVSGVVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,0.0
|
| 51 |
+
T67V,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGVRRIITGEATQEDYYTGDHYATFSLIDQTC,-0.1
|
| 52 |
+
T72V,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIIVGEATQEDYYTGDHYATFSLIDQTC,-0.8
|
| 53 |
+
T82V,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYVGDHYATFSLIDQTC,-5.7
|
| 54 |
+
T95A,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQAC,-2.1
|
| 55 |
+
V2T,DTSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-3.2
|
| 56 |
+
V36T,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVTFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-4.6
|
| 57 |
+
V43T,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESTLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-1.6
|
| 58 |
+
V57T,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTTITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-15.0
|
| 59 |
+
Y30F,DVSGTVCLSALPPEATDTLNLIASDGPFPFSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,1.2
|
| 60 |
+
Y49F,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSFGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-0.8
|
| 61 |
+
Y51F,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGFYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-7.6
|
| 62 |
+
Y52F,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYFHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-12.1
|
| 63 |
+
Y55F,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEFTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC,-1.9
|
| 64 |
+
Y80F,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDFYTGDHYATFSLIDQTC,-5.2
|
| 65 |
+
Y81F,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYFTGDHYATFSLIDQTC,-3.9
|
| 66 |
+
Y86F,DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHFATFSLIDQTC,-1.1
|
mutant/stability/S4346_1LZ1_dTm.csv
CHANGED
|
@@ -1,133 +1,133 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A32L,-0.3
|
| 3 |
-
A32S,-1.0
|
| 4 |
-
A47P,0.3
|
| 5 |
-
A92S,2.6
|
| 6 |
-
A96M,0.1
|
| 7 |
-
A96S,-3.3
|
| 8 |
-
A9S,-0.1
|
| 9 |
-
C77A,-14.3
|
| 10 |
-
D102N,-0.6333333333333333
|
| 11 |
-
D120N,-0.65
|
| 12 |
-
D18N,-3.05
|
| 13 |
-
D49N,-1.35
|
| 14 |
-
D67N,-3.475
|
| 15 |
-
D91P,-1.1
|
| 16 |
-
E35L,-1.8
|
| 17 |
-
E7Q,-2.275
|
| 18 |
-
G105A,-2.1
|
| 19 |
-
G127A,-1.7
|
| 20 |
-
G129A,0.5
|
| 21 |
-
G16A,-4.6
|
| 22 |
-
G19A,-5.5
|
| 23 |
-
G22A,-7.2
|
| 24 |
-
G37A,-0.9
|
| 25 |
-
G37Q,-0.8
|
| 26 |
-
G48A,1.5
|
| 27 |
-
G68A,-0.4
|
| 28 |
-
G72A,-1.1
|
| 29 |
-
H78A,-0.5
|
| 30 |
-
H78G,-0.5
|
| 31 |
-
I106A,-3.0
|
| 32 |
-
I106V,-2.2
|
| 33 |
-
I23A,-8.1
|
| 34 |
-
I23V,-1.6
|
| 35 |
-
I56A,-12.5
|
| 36 |
-
I56F,-15.0
|
| 37 |
-
I56G,-2.7
|
| 38 |
-
I56L,-0.3
|
| 39 |
-
I56M,-5.8
|
| 40 |
-
I56T,-12.5
|
| 41 |
-
I56V,-3.6
|
| 42 |
-
I59A,-5.2
|
| 43 |
-
I59F,-2.6
|
| 44 |
-
I59G,-12.7
|
| 45 |
-
I59L,0.0
|
| 46 |
-
I59M,-4.2
|
| 47 |
-
I59S,-11.8
|
| 48 |
-
I59T,-6.9
|
| 49 |
-
I59V,-4.4
|
| 50 |
-
I59Y,-13.8
|
| 51 |
-
I89A,-8.7
|
| 52 |
-
I89V,-1.4
|
| 53 |
-
K1A,-2.2
|
| 54 |
-
K1M,-0.5
|
| 55 |
-
L8T,-12.4
|
| 56 |
-
N118A,0.6
|
| 57 |
-
N118G,0.2
|
| 58 |
-
N27L,0.4
|
| 59 |
-
P103G,-0.1
|
| 60 |
-
P71G,-4.7
|
| 61 |
-
Q58A,3.1
|
| 62 |
-
Q58G,5.7
|
| 63 |
-
R21A,4.5
|
| 64 |
-
R21G,3.7
|
| 65 |
-
R50A,1.4
|
| 66 |
-
R50G,0.9
|
| 67 |
-
S24A,-1.6
|
| 68 |
-
S36A,-3.5
|
| 69 |
-
S51A,-0.7
|
| 70 |
-
S61A,-4.3
|
| 71 |
-
S80A,1.4
|
| 72 |
-
S82A,1.1
|
| 73 |
-
T11A,1.2
|
| 74 |
-
T11V,1.0
|
| 75 |
-
T40A,-4.7
|
| 76 |
-
T40V,-4.2
|
| 77 |
-
T43A,-1.1
|
| 78 |
-
T43V,3.2
|
| 79 |
-
T52A,-2.9
|
| 80 |
-
T52V,-2.8
|
| 81 |
-
T70A,-4.7
|
| 82 |
-
T70V,-2.1
|
| 83 |
-
V100A,-0.8
|
| 84 |
-
V100F,-6.5
|
| 85 |
-
V100T,-0.9
|
| 86 |
-
V110A,1.5
|
| 87 |
-
V110D,0.5
|
| 88 |
-
V110F,-0.2
|
| 89 |
-
V110G,1.6
|
| 90 |
-
V110I,2.7
|
| 91 |
-
V110L,0.2
|
| 92 |
-
V110M,1.6
|
| 93 |
-
V110N,0.2
|
| 94 |
-
V110P,1.2
|
| 95 |
-
V110R,2.9
|
| 96 |
-
V110Y,-0.5
|
| 97 |
-
V121A,-6.1
|
| 98 |
-
V125A,-4.0
|
| 99 |
-
V130A,-2.6
|
| 100 |
-
V2A,-4.6
|
| 101 |
-
V2D,-4.5
|
| 102 |
-
V2F,-2.7
|
| 103 |
-
V2G,-7.5
|
| 104 |
-
V2I,3.4
|
| 105 |
-
V2L,-0.2
|
| 106 |
-
V2M,-1.0
|
| 107 |
-
V2N,-4.1
|
| 108 |
-
V2R,-1.3
|
| 109 |
-
V2S,-4.4
|
| 110 |
-
V2Y,-1.2
|
| 111 |
-
V74A,-1.1
|
| 112 |
-
V74D,-1.4
|
| 113 |
-
V74F,-0.9
|
| 114 |
-
V74G,-0.7
|
| 115 |
-
V74I,1.7
|
| 116 |
-
V74L,0.6
|
| 117 |
-
V74M,2.0
|
| 118 |
-
V74N,-1.0
|
| 119 |
-
V74R,-0.3
|
| 120 |
-
V74S,-1.2
|
| 121 |
-
V74Y,-0.9
|
| 122 |
-
V93A,-2.3
|
| 123 |
-
V93T,-2.3
|
| 124 |
-
V99A,-3.0
|
| 125 |
-
V99T,-1.6
|
| 126 |
-
Y124F,-1.1
|
| 127 |
-
Y20F,-1.5
|
| 128 |
-
Y38A,-8.9
|
| 129 |
-
Y38F,-0.6
|
| 130 |
-
Y38G,-8.2
|
| 131 |
-
Y45F,0.2
|
| 132 |
-
Y54F,-3.0
|
| 133 |
-
Y63F,-0.7
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A32L,KVFERCELARTLKRLGMDGYRGISLANWMCLLKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.3
|
| 3 |
+
A32S,KVFERCELARTLKRLGMDGYRGISLANWMCLSKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.0
|
| 4 |
+
A47P,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNPGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,0.3
|
| 5 |
+
A92S,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADSVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,2.6
|
| 6 |
+
A96M,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACMKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,0.1
|
| 7 |
+
A96S,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACSKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-3.3
|
| 8 |
+
A9S,KVFERCELSRTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.1
|
| 9 |
+
C77A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNAAHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-14.3
|
| 10 |
+
D102N,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRNPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.6333333333333333
|
| 11 |
+
D120N,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRNVRQYVQGCGV,-0.65
|
| 12 |
+
D18N,KVFERCELARTLKRLGMNGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-3.05
|
| 13 |
+
D49N,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGNRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.35
|
| 14 |
+
D67N,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNNGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-3.475
|
| 15 |
+
D91P,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIAPAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.1
|
| 16 |
+
E35L,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWLSGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.8
|
| 17 |
+
E7Q,KVFERCQLARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-2.275
|
| 18 |
+
G105A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQAIRAWVAWRNRCQNRDVRQYVQGCGV,-2.1
|
| 19 |
+
G127A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQACGV,-1.7
|
| 20 |
+
G129A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCAV,0.5
|
| 21 |
+
G16A,KVFERCELARTLKRLAMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-4.6
|
| 22 |
+
G19A,KVFERCELARTLKRLGMDAYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-5.5
|
| 23 |
+
G22A,KVFERCELARTLKRLGMDGYRAISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-7.2
|
| 24 |
+
G37A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESAYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.9
|
| 25 |
+
G37Q,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESQYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.8
|
| 26 |
+
G48A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAADRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,1.5
|
| 27 |
+
G68A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDAKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.4
|
| 28 |
+
G72A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPAAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.1
|
| 29 |
+
H78A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACALSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.5
|
| 30 |
+
H78G,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACGLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.5
|
| 31 |
+
I106A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGARAWVAWRNRCQNRDVRQYVQGCGV,-3.0
|
| 32 |
+
I106V,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGVRAWVAWRNRCQNRDVRQYVQGCGV,-2.2
|
| 33 |
+
I23A,KVFERCELARTLKRLGMDGYRGASLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-8.1
|
| 34 |
+
I23V,KVFERCELARTLKRLGMDGYRGVSLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.6
|
| 35 |
+
I56A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGAFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-12.5
|
| 36 |
+
I56F,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGFFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-15.0
|
| 37 |
+
I56G,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGGFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-2.7
|
| 38 |
+
I56L,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGLFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.3
|
| 39 |
+
I56M,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGMFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-5.8
|
| 40 |
+
I56T,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGTFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-12.5
|
| 41 |
+
I56V,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGVFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-3.6
|
| 42 |
+
I59A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQANSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-5.2
|
| 43 |
+
I59F,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQFNSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-2.6
|
| 44 |
+
I59G,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQGNSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-12.7
|
| 45 |
+
I59L,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQLNSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,0.0
|
| 46 |
+
I59M,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQMNSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-4.2
|
| 47 |
+
I59S,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQSNSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-11.8
|
| 48 |
+
I59T,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQTNSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-6.9
|
| 49 |
+
I59V,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQVNSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-4.4
|
| 50 |
+
I59Y,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQYNSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-13.8
|
| 51 |
+
I89A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNAADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-8.7
|
| 52 |
+
I89V,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNVADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.4
|
| 53 |
+
K1A,AVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-2.2
|
| 54 |
+
K1M,MVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.5
|
| 55 |
+
L8T,KVFERCETARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-12.4
|
| 56 |
+
N118A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQARDVRQYVQGCGV,0.6
|
| 57 |
+
N118G,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQGRDVRQYVQGCGV,0.2
|
| 58 |
+
N27L,KVFERCELARTLKRLGMDGYRGISLALWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,0.4
|
| 59 |
+
P103G,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDGQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.1
|
| 60 |
+
P71G,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTGGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-4.7
|
| 61 |
+
Q58A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFAINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,3.1
|
| 62 |
+
Q58G,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFGINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,5.7
|
| 63 |
+
R21A,KVFERCELARTLKRLGMDGYAGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,4.5
|
| 64 |
+
R21G,KVFERCELARTLKRLGMDGYGGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,3.7
|
| 65 |
+
R50A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDASTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,1.4
|
| 66 |
+
R50G,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDGSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,0.9
|
| 67 |
+
S24A,KVFERCELARTLKRLGMDGYRGIALANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.6
|
| 68 |
+
S36A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWEAGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-3.5
|
| 69 |
+
S51A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRATDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.7
|
| 70 |
+
S61A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINARYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-4.3
|
| 71 |
+
S80A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLACSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,1.4
|
| 72 |
+
S82A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCAALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,1.1
|
| 73 |
+
T11A,KVFERCELARALKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,1.2
|
| 74 |
+
T11V,KVFERCELARVLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,1.0
|
| 75 |
+
T40A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNARATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-4.7
|
| 76 |
+
T40V,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNVRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-4.2
|
| 77 |
+
T43A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRAANYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.1
|
| 78 |
+
T43V,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRAVNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,3.2
|
| 79 |
+
T52A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSADYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-2.9
|
| 80 |
+
T52V,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSVDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-2.8
|
| 81 |
+
T70A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKAPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-4.7
|
| 82 |
+
T70V,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKVPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-2.1
|
| 83 |
+
V100A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVARDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.8
|
| 84 |
+
V100F,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVFRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-6.5
|
| 85 |
+
V100T,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVTRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.9
|
| 86 |
+
V110A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWAAWRNRCQNRDVRQYVQGCGV,1.5
|
| 87 |
+
V110D,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWDAWRNRCQNRDVRQYVQGCGV,0.5
|
| 88 |
+
V110F,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWFAWRNRCQNRDVRQYVQGCGV,-0.2
|
| 89 |
+
V110G,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWGAWRNRCQNRDVRQYVQGCGV,1.6
|
| 90 |
+
V110I,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWIAWRNRCQNRDVRQYVQGCGV,2.7
|
| 91 |
+
V110L,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWLAWRNRCQNRDVRQYVQGCGV,0.2
|
| 92 |
+
V110M,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWMAWRNRCQNRDVRQYVQGCGV,1.6
|
| 93 |
+
V110N,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWNAWRNRCQNRDVRQYVQGCGV,0.2
|
| 94 |
+
V110P,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWPAWRNRCQNRDVRQYVQGCGV,1.2
|
| 95 |
+
V110R,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWRAWRNRCQNRDVRQYVQGCGV,2.9
|
| 96 |
+
V110Y,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWYAWRNRCQNRDVRQYVQGCGV,-0.5
|
| 97 |
+
V121A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDARQYVQGCGV,-6.1
|
| 98 |
+
V125A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYAQGCGV,-4.0
|
| 99 |
+
V130A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGA,-2.6
|
| 100 |
+
V2A,KAFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-4.6
|
| 101 |
+
V2D,KDFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-4.5
|
| 102 |
+
V2F,KFFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-2.7
|
| 103 |
+
V2G,KGFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-7.5
|
| 104 |
+
V2I,KIFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,3.4
|
| 105 |
+
V2L,KLFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.2
|
| 106 |
+
V2M,KMFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.0
|
| 107 |
+
V2N,KNFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-4.1
|
| 108 |
+
V2R,KRFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.3
|
| 109 |
+
V2S,KSFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-4.4
|
| 110 |
+
V2Y,KYFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.2
|
| 111 |
+
V74A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAANACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.1
|
| 112 |
+
V74D,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGADNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.4
|
| 113 |
+
V74F,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAFNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.9
|
| 114 |
+
V74G,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAGNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.7
|
| 115 |
+
V74I,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAINACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,1.7
|
| 116 |
+
V74L,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGALNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,0.6
|
| 117 |
+
V74M,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAMNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,2.0
|
| 118 |
+
V74N,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGANNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.0
|
| 119 |
+
V74R,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGARNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.3
|
| 120 |
+
V74S,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGASNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.2
|
| 121 |
+
V74Y,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAYNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.9
|
| 122 |
+
V93A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAAACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-2.3
|
| 123 |
+
V93T,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADATACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-2.3
|
| 124 |
+
V99A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRAVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-3.0
|
| 125 |
+
V99T,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRTVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.6
|
| 126 |
+
Y124F,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQFVQGCGV,-1.1
|
| 127 |
+
Y20F,KVFERCELARTLKRLGMDGFRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-1.5
|
| 128 |
+
Y38A,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGANTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-8.9
|
| 129 |
+
Y38F,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGFNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.6
|
| 130 |
+
Y38G,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGGNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-8.2
|
| 131 |
+
Y45F,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNFNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,0.2
|
| 132 |
+
Y54F,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDFGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-3.0
|
| 133 |
+
Y63F,KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRFWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV,-0.7
|
mutant/stability/S4346_1RN1_dTm.csv
CHANGED
|
@@ -1,42 +1,42 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
D49A,1.7
|
| 3 |
-
D49F,0.4
|
| 4 |
-
D49H,3.4
|
| 5 |
-
D49W,-1.1
|
| 6 |
-
D49Y,0.1
|
| 7 |
-
D76A,-15.2
|
| 8 |
-
D76N,-13.8
|
| 9 |
-
D76S,-13.6
|
| 10 |
-
E58A,-2.3
|
| 11 |
-
H40T,-0.5
|
| 12 |
-
H92A,-1.3
|
| 13 |
-
N36A,0.0
|
| 14 |
-
N44A,-5.2
|
| 15 |
-
N44D,-5.5
|
| 16 |
-
N44S,-5.0
|
| 17 |
-
N81A,-8.6
|
| 18 |
-
N9A,-2.1
|
| 19 |
-
P73V,-5.8
|
| 20 |
-
Q25K,3.03
|
| 21 |
-
S12A,-3.2
|
| 22 |
-
S17A,1.7000000000000002
|
| 23 |
-
S64A,-4.6
|
| 24 |
-
V16A,-7.6
|
| 25 |
-
V16C,-9.3
|
| 26 |
-
V16S,-15.1
|
| 27 |
-
V16T,-10.4
|
| 28 |
-
V78A,-7.9
|
| 29 |
-
V78S,-16.6
|
| 30 |
-
V78T,-9.8
|
| 31 |
-
V89C,-4.9
|
| 32 |
-
V89S,-21.6
|
| 33 |
-
V89T,-13.2
|
| 34 |
-
W59Y,2.5
|
| 35 |
-
Y11F,-6.0
|
| 36 |
-
Y24W,1.6
|
| 37 |
-
Y42F,3.4
|
| 38 |
-
Y42W,-0.6
|
| 39 |
-
Y45W,-1.4500000000000002
|
| 40 |
-
Y56F,-2.1
|
| 41 |
-
Y57F,-1.3
|
| 42 |
-
Y68F,-4.0
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
D49A,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFAFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,1.7
|
| 3 |
+
D49F,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFFFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,0.4
|
| 4 |
+
D49H,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFHFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,3.4
|
| 5 |
+
D49W,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFWFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-1.1
|
| 6 |
+
D49Y,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFYFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,0.1
|
| 7 |
+
D76A,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGAARVVFNENNQLAGVITHTGASGNNFVECT,-15.2
|
| 8 |
+
D76N,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGANRVVFNENNQLAGVITHTGASGNNFVECT,-13.8
|
| 9 |
+
D76S,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGASRVVFNENNQLAGVITHTGASGNNFVECT,-13.6
|
| 10 |
+
E58A,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYAWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-2.3
|
| 11 |
+
H40T,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPTKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-0.5
|
| 12 |
+
H92A,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITATGASGNNFVECT,-1.3
|
| 13 |
+
N36A,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSASYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,0.0
|
| 14 |
+
N44A,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNAYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-5.2
|
| 15 |
+
N44D,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNDYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-5.5
|
| 16 |
+
N44S,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNSYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-5.0
|
| 17 |
+
N81A,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFAENNQLAGVITHTGASGNNFVECT,-8.6
|
| 18 |
+
N9A,ACDYTCGSACYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-2.1
|
| 19 |
+
P73V,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSVGADRVVFNENNQLAGVITHTGASGNNFVECT,-5.8
|
| 20 |
+
Q25K,ACDYTCGSNCYSSSDVSTAQAAGYKLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,3.03
|
| 21 |
+
S12A,ACDYTCGSNCYASSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-3.2
|
| 22 |
+
S17A,ACDYTCGSNCYSSSDVATAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,1.7000000000000002
|
| 23 |
+
S64A,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSAGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-4.6
|
| 24 |
+
V16A,ACDYTCGSNCYSSSDASTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-7.6
|
| 25 |
+
V16C,ACDYTCGSNCYSSSDCSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-9.3
|
| 26 |
+
V16S,ACDYTCGSNCYSSSDSSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-15.1
|
| 27 |
+
V16T,ACDYTCGSNCYSSSDTSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-10.4
|
| 28 |
+
V78A,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRAVFNENNQLAGVITHTGASGNNFVECT,-7.9
|
| 29 |
+
V78S,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRSVFNENNQLAGVITHTGASGNNFVECT,-16.6
|
| 30 |
+
V78T,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRTVFNENNQLAGVITHTGASGNNFVECT,-9.8
|
| 31 |
+
V89C,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGCITHTGASGNNFVECT,-4.9
|
| 32 |
+
V89S,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGSITHTGASGNNFVECT,-21.6
|
| 33 |
+
V89T,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGTITHTGASGNNFVECT,-13.2
|
| 34 |
+
W59Y,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEYPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,2.5
|
| 35 |
+
Y11F,ACDYTCGSNCFSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-6.0
|
| 36 |
+
Y24W,ACDYTCGSNCYSSSDVSTAQAAGWQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,1.6
|
| 37 |
+
Y42F,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKFNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,3.4
|
| 38 |
+
Y42W,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKWNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-0.6
|
| 39 |
+
Y45W,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNWEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-1.4500000000000002
|
| 40 |
+
Y56F,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPFYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-2.1
|
| 41 |
+
Y57F,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYFEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-1.3
|
| 42 |
+
Y68F,ACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVFSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT,-4.0
|
mutant/stability/S4346_1SHG_dTm.csv
CHANGED
|
@@ -1,6 +1,6 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A56E,-3.8
|
| 3 |
-
A56G,-4.6
|
| 4 |
-
A56K,-0.6
|
| 5 |
-
D48G,7.925000000000001
|
| 6 |
-
N47A,-5.699999999999999
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A56E,MDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAEYVKKLD,-3.8
|
| 3 |
+
A56G,MDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAGYVKKLD,-4.6
|
| 4 |
+
A56K,MDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAKYVKKLD,-0.6
|
| 5 |
+
D48G,MDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNGRQGFVPAAYVKKLD,7.925000000000001
|
| 6 |
+
N47A,MDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVADRQGFVPAAYVKKLD,-5.699999999999999
|
mutant/stability/S4346_1WQ5_dTm.csv
CHANGED
|
@@ -1,49 +1,49 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A67V,-2.7
|
| 3 |
-
C118A,-4.3
|
| 4 |
-
C118S,-8.5
|
| 5 |
-
C118V,-4.2
|
| 6 |
-
C154A,-2.9
|
| 7 |
-
C154S,-8.2
|
| 8 |
-
C154V,-3.3
|
| 9 |
-
C81A,-1.7
|
| 10 |
-
C81G,-4.8
|
| 11 |
-
C81S,-4.4
|
| 12 |
-
C81V,-4.4
|
| 13 |
-
D112G,-5.1
|
| 14 |
-
D112N,-3.1
|
| 15 |
-
D56G,-2.0
|
| 16 |
-
D60G,-2.6
|
| 17 |
-
E49G,-1.8
|
| 18 |
-
E49Q,2.55
|
| 19 |
-
E49S,1.2
|
| 20 |
-
F114L,-3.3
|
| 21 |
-
F22S,0.8
|
| 22 |
-
G211E,1.8
|
| 23 |
-
G211R,0.2
|
| 24 |
-
G51D,-4.5
|
| 25 |
-
K109N,-1.5
|
| 26 |
-
M101I,3.7
|
| 27 |
-
M101T,7.6
|
| 28 |
-
M101V,7.6
|
| 29 |
-
P132A,-2.6
|
| 30 |
-
P132G,-2.3
|
| 31 |
-
P207A,-6.7
|
| 32 |
-
P21S,-4.3
|
| 33 |
-
P28L,-4.6
|
| 34 |
-
P28S,-6.4
|
| 35 |
-
P53H,-3.3
|
| 36 |
-
P53T,-4.3
|
| 37 |
-
P62A,-1.4
|
| 38 |
-
P62Q,-0.6
|
| 39 |
-
P78L,1.9
|
| 40 |
-
P78S,-1.6
|
| 41 |
-
P96A,-6.3
|
| 42 |
-
Q65R,-0.6000000000000001
|
| 43 |
-
S33L,-7.6
|
| 44 |
-
S6P,-5.2
|
| 45 |
-
T24M,2.3
|
| 46 |
-
T63K,-3.3
|
| 47 |
-
Y102C,1.4
|
| 48 |
-
Y102H,0.8
|
| 49 |
-
Y115C,-2.3
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A67V,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNVTLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-2.7
|
| 3 |
+
C118A,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQAEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-4.3
|
| 4 |
+
C118S,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQSEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-8.5
|
| 5 |
+
C118V,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQVEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-4.2
|
| 6 |
+
C154A,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFIAPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-2.9
|
| 7 |
+
C154S,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFISPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-8.2
|
| 8 |
+
C154V,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFIVPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-3.3
|
| 9 |
+
C81A,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQAFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-1.7
|
| 10 |
+
C81G,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQGFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-4.8
|
| 11 |
+
C81S,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQSFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-4.4
|
| 12 |
+
C81V,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQVFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-4.4
|
| 13 |
+
D112G,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIGEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-5.1
|
| 14 |
+
D112N,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGINEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-3.1
|
| 15 |
+
D56G,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSGPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-2.0
|
| 16 |
+
D60G,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLAGGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-2.6
|
| 17 |
+
E49G,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALGLGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-1.8
|
| 18 |
+
E49Q,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALQLGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,2.55
|
| 19 |
+
E49S,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALSLGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,1.2
|
| 20 |
+
F114L,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDELYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-3.3
|
| 21 |
+
F22S,MERYESLFAQLKERKEGAFVPSVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,0.8
|
| 22 |
+
G211E,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQEFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,1.8
|
| 23 |
+
G211R,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQRFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,0.2
|
| 24 |
+
G51D,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELDIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-4.5
|
| 25 |
+
K109N,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNNGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-1.5
|
| 26 |
+
M101I,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLIYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,3.7
|
| 27 |
+
M101T,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLTYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,7.6
|
| 28 |
+
M101V,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLVYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,7.6
|
| 29 |
+
P132A,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVAVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-2.6
|
| 30 |
+
P132G,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVGVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-2.3
|
| 31 |
+
P207A,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAAPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-6.7
|
| 32 |
+
P21S,MERYESLFAQLKERKEGAFVSFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-4.3
|
| 33 |
+
P28L,MERYESLFAQLKERKEGAFVPFVTLGDLGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-4.6
|
| 34 |
+
P28S,MERYESLFAQLKERKEGAFVPFVTLGDSGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-6.4
|
| 35 |
+
P53H,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIHFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-3.3
|
| 36 |
+
P53T,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGITFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-4.3
|
| 37 |
+
P62A,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGATIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-1.4
|
| 38 |
+
P62Q,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGQTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-0.6
|
| 39 |
+
P78L,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTLAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,1.9
|
| 40 |
+
P78S,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTSAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-1.6
|
| 41 |
+
P96A,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIAIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-6.3
|
| 42 |
+
Q65R,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIRNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-0.6000000000000001
|
| 43 |
+
S33L,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQLLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-7.6
|
| 44 |
+
S6P,MERYEPLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-5.2
|
| 45 |
+
T24M,MERYESLFAQLKERKEGAFVPFVMLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,2.3
|
| 46 |
+
T63K,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPKIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-3.3
|
| 47 |
+
Y102C,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMCANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,1.4
|
| 48 |
+
Y102H,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMHANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,0.8
|
| 49 |
+
Y115C,MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFCAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS,-2.3
|
mutant/stability/S4346_2CI2_dTm.csv
CHANGED
|
@@ -1,27 +1,27 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
E33N,-3.8
|
| 3 |
-
E45A,-1.4
|
| 4 |
-
F69L,-14.1
|
| 5 |
-
I39V,-10.65
|
| 6 |
-
I48A,-21.3
|
| 7 |
-
I48V,-5.95
|
| 8 |
-
I49V,1.4
|
| 9 |
-
I76A,-24.6
|
| 10 |
-
I76V,1.25
|
| 11 |
-
K36A,-12.6
|
| 12 |
-
K37A,-5.2
|
| 13 |
-
K37G,-10.8
|
| 14 |
-
K43A,-3.55
|
| 15 |
-
L27A,-19.0
|
| 16 |
-
L51A,-9.1
|
| 17 |
-
L51V,-0.5
|
| 18 |
-
L68A,-21.5
|
| 19 |
-
P44A,-9.1
|
| 20 |
-
S31A,-7.1
|
| 21 |
-
S31G,-4.6
|
| 22 |
-
T22A,-2.9
|
| 23 |
-
V38A,-3.8
|
| 24 |
-
V53A,-2.8
|
| 25 |
-
V53T,-8.3
|
| 26 |
-
V66A,-28.5
|
| 27 |
-
V70A,-14.75
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
E33N,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVNEAKKVILQDKPEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-3.8
|
| 3 |
+
E45A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKPAAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-1.4
|
| 4 |
+
F69L,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKPEAQIIVLPVGTIVTMEYRIDRVRLLVDKLDNIAEVPRVG,-14.1
|
| 5 |
+
I39V,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVVLQDKPEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-10.65
|
| 6 |
+
I48A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKPEAQAIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-21.3
|
| 7 |
+
I48V,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKPEAQVIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-5.95
|
| 8 |
+
I49V,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKPEAQIVVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,1.4
|
| 9 |
+
I76A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKPEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNAAEVPRVG,-24.6
|
| 10 |
+
I76V,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKPEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNVAEVPRVG,1.25
|
| 11 |
+
K36A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAAKVILQDKPEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-12.6
|
| 12 |
+
K37A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKAVILQDKPEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-5.2
|
| 13 |
+
K37G,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKGVILQDKPEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-10.8
|
| 14 |
+
K43A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDAPEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-3.55
|
| 15 |
+
L27A,SSVEKKPEGVNTGAGDRHNLKTEWPEAVGKSVEEAKKVILQDKPEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-19.0
|
| 16 |
+
L51A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKPEAQIIVAPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-9.1
|
| 17 |
+
L51V,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKPEAQIIVVPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-0.5
|
| 18 |
+
L68A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKPEAQIIVLPVGTIVTMEYRIDRVRAFVDKLDNIAEVPRVG,-21.5
|
| 19 |
+
P44A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKAEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-9.1
|
| 20 |
+
S31A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKAVEEAKKVILQDKPEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-7.1
|
| 21 |
+
S31G,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKGVEEAKKVILQDKPEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-4.6
|
| 22 |
+
T22A,SSVEKKPEGVNTGAGDRHNLKAEWPELVGKSVEEAKKVILQDKPEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-2.9
|
| 23 |
+
V38A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKAILQDKPEAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-3.8
|
| 24 |
+
V53A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKPEAQIIVLPAGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-2.8
|
| 25 |
+
V53T,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKPEAQIIVLPTGTIVTMEYRIDRVRLFVDKLDNIAEVPRVG,-8.3
|
| 26 |
+
V66A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKPEAQIIVLPVGTIVTMEYRIDRARLFVDKLDNIAEVPRVG,-28.5
|
| 27 |
+
V70A,SSVEKKPEGVNTGAGDRHNLKTEWPELVGKSVEEAKKVILQDKPEAQIIVLPVGTIVTMEYRIDRVRLFADKLDNIAEVPRVG,-14.75
|
mutant/stability/S4346_2LZM_dTm.csv
CHANGED
|
The diff for this file is too large to render.
See raw diff
|
|
|
mutant/stability/S4346_2RN2_dTm.csv
CHANGED
|
@@ -1,74 +1,74 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A125T,0.2
|
| 3 |
-
A24V,2.8
|
| 4 |
-
A52C,2.5
|
| 5 |
-
A52D,-6.1
|
| 6 |
-
A52E,-5.0
|
| 7 |
-
A52F,-1.5
|
| 8 |
-
A52G,-8.9
|
| 9 |
-
A52H,-11.8
|
| 10 |
-
A52I,6.2
|
| 11 |
-
A52K,-19.5
|
| 12 |
-
A52L,4.3
|
| 13 |
-
A52M,1.6
|
| 14 |
-
A52N,-5.9
|
| 15 |
-
A52P,-5.4
|
| 16 |
-
A52Q,-3.9
|
| 17 |
-
A52S,-5.8
|
| 18 |
-
A52T,-2.7
|
| 19 |
-
A52V,7.033333333333334
|
| 20 |
-
A52Y,-7.6
|
| 21 |
-
D10A,12.2
|
| 22 |
-
D10E,3.6
|
| 23 |
-
D10H,4.85
|
| 24 |
-
D10N,0.3
|
| 25 |
-
D10S,5.8
|
| 26 |
-
D134A,5.066666666666666
|
| 27 |
-
D134E,2.75
|
| 28 |
-
D134H,4.35
|
| 29 |
-
D134I,3.45
|
| 30 |
-
D134L,4.65
|
| 31 |
-
D134N,3.233333333333334
|
| 32 |
-
D134Q,3.2
|
| 33 |
-
D134S,2.4
|
| 34 |
-
D134T,2.15
|
| 35 |
-
D134V,2.6
|
| 36 |
-
D70A,1.75
|
| 37 |
-
D70E,1.1
|
| 38 |
-
D70N,2.15
|
| 39 |
-
D94E,-1.4
|
| 40 |
-
E119V,1.5
|
| 41 |
-
E135K,-2.25
|
| 42 |
-
E48A,-0.6
|
| 43 |
-
E48D,0.0
|
| 44 |
-
E48Q,0.4
|
| 45 |
-
G23A,2.05
|
| 46 |
-
G77A,-2.9
|
| 47 |
-
H114A,-5.0
|
| 48 |
-
H124A,0.6000000000000001
|
| 49 |
-
H127A,0.9
|
| 50 |
-
H62A,1.15
|
| 51 |
-
H62D,0.8
|
| 52 |
-
H62P,3.75
|
| 53 |
-
H62R,0.6
|
| 54 |
-
H83A,0.6666666666666666
|
| 55 |
-
I53A,-12.1
|
| 56 |
-
K117R,-0.05
|
| 57 |
-
K91R,0.3
|
| 58 |
-
K95A,0.35
|
| 59 |
-
K95G,6.25
|
| 60 |
-
K95N,3.05
|
| 61 |
-
Q105G,-9.6
|
| 62 |
-
Q113P,-1.35
|
| 63 |
-
Q76L,0.95
|
| 64 |
-
Q80L,0.9
|
| 65 |
-
R27A,-5.6
|
| 66 |
-
R41C,1.0
|
| 67 |
-
S68A,-1.5
|
| 68 |
-
S68G,-8.0
|
| 69 |
-
S68L,-1.6
|
| 70 |
-
S68T,-0.7
|
| 71 |
-
S68V,1.9
|
| 72 |
-
V74A,-10.15
|
| 73 |
-
V74I,2.25
|
| 74 |
-
V74L,3.5
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A125T,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHTGHPENERCDELARAAAMNPTLEDTGYQVEV,0.2
|
| 3 |
+
A24V,MLKQVEIFTDGSCLGNPGPGGYGVILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,2.8
|
| 4 |
+
A52C,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMACIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,2.5
|
| 5 |
+
A52D,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMADIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-6.1
|
| 6 |
+
A52E,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAEIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-5.0
|
| 7 |
+
A52F,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAFIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-1.5
|
| 8 |
+
A52G,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAGIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-8.9
|
| 9 |
+
A52H,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAHIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-11.8
|
| 10 |
+
A52I,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAIIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,6.2
|
| 11 |
+
A52K,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAKIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-19.5
|
| 12 |
+
A52L,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMALIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,4.3
|
| 13 |
+
A52M,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAMIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,1.6
|
| 14 |
+
A52N,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMANIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-5.9
|
| 15 |
+
A52P,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAPIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-5.4
|
| 16 |
+
A52Q,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAQIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-3.9
|
| 17 |
+
A52S,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMASIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-5.8
|
| 18 |
+
A52T,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMATIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-2.7
|
| 19 |
+
A52V,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAVIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,7.033333333333334
|
| 20 |
+
A52Y,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAYIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-7.6
|
| 21 |
+
D10A,MLKQVEIFTAGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,12.2
|
| 22 |
+
D10E,MLKQVEIFTEGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,3.6
|
| 23 |
+
D10H,MLKQVEIFTHGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,4.85
|
| 24 |
+
D10N,MLKQVEIFTNGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.3
|
| 25 |
+
D10S,MLKQVEIFTSGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,5.8
|
| 26 |
+
D134A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCAELARAAAMNPTLEDTGYQVEV,5.066666666666666
|
| 27 |
+
D134E,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCEELARAAAMNPTLEDTGYQVEV,2.75
|
| 28 |
+
D134H,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCHELARAAAMNPTLEDTGYQVEV,4.35
|
| 29 |
+
D134I,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCIELARAAAMNPTLEDTGYQVEV,3.45
|
| 30 |
+
D134L,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCLELARAAAMNPTLEDTGYQVEV,4.65
|
| 31 |
+
D134N,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCNELARAAAMNPTLEDTGYQVEV,3.233333333333334
|
| 32 |
+
D134Q,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCQELARAAAMNPTLEDTGYQVEV,3.2
|
| 33 |
+
D134S,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCSELARAAAMNPTLEDTGYQVEV,2.4
|
| 34 |
+
D134T,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCTELARAAAMNPTLEDTGYQVEV,2.15
|
| 35 |
+
D134V,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCVELARAAAMNPTLEDTGYQVEV,2.6
|
| 36 |
+
D70A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTASQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,1.75
|
| 37 |
+
D70E,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTESQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,1.1
|
| 38 |
+
D70N,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTNSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,2.15
|
| 39 |
+
D94E,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTAEKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-1.4
|
| 40 |
+
E119V,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWVWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,1.5
|
| 41 |
+
E135K,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDKLARAAAMNPTLEDTGYQVEV,-2.25
|
| 42 |
+
E48A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMALMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-0.6
|
| 43 |
+
E48D,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMDLMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.0
|
| 44 |
+
E48Q,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMQLMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.4
|
| 45 |
+
G23A,MLKQVEIFTDGSCLGNPGPGGYAAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,2.05
|
| 46 |
+
G77A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQAITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-2.9
|
| 47 |
+
H114A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQAQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-5.0
|
| 48 |
+
H124A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGAAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.6000000000000001
|
| 49 |
+
H127A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGAPENERCDELARAAAMNPTLEDTGYQVEV,0.9
|
| 50 |
+
H62A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEACEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,1.15
|
| 51 |
+
H62D,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEDCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.8
|
| 52 |
+
H62P,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEPCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,3.75
|
| 53 |
+
H62R,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKERCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.6
|
| 54 |
+
H83A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIANWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.6666666666666666
|
| 55 |
+
I53A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAAVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-12.1
|
| 56 |
+
K117R,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIRWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-0.05
|
| 57 |
+
K91R,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWRTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.3
|
| 58 |
+
K95A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADAKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.35
|
| 59 |
+
K95G,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADGKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,6.25
|
| 60 |
+
K95N,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADNKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,3.05
|
| 61 |
+
Q105G,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWGRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-9.6
|
| 62 |
+
Q113P,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGPHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-1.35
|
| 63 |
+
Q76L,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRLGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.95
|
| 64 |
+
Q80L,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITLWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,0.9
|
| 65 |
+
R27A,MLKQVEIFTDGSCLGNPGPGGYGAILAYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-5.6
|
| 66 |
+
R41C,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTCTTNNRMELMAAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,1.0
|
| 67 |
+
S68A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILATDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-1.5
|
| 68 |
+
S68G,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILGTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-8.0
|
| 69 |
+
S68L,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILLTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-1.6
|
| 70 |
+
S68T,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILTTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-0.7
|
| 71 |
+
S68V,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILVTDSQYVRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,1.9
|
| 72 |
+
V74A,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYARQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,-10.15
|
| 73 |
+
V74I,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYIRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,2.25
|
| 74 |
+
V74L,MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELMAAIVALEALKEHCEVILSTDSQYLRQGITQWIHNWKKRGWKTADKKPVKNVDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTGYQVEV,3.5
|
mutant/stability/S4346_3MBP_dTm.csv
CHANGED
|
@@ -1,7 +1,7 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
P133A,-0.625
|
| 3 |
-
P133S,-4.5600000000000005
|
| 4 |
-
P159A,-4.19
|
| 5 |
-
P159S,-4.21
|
| 6 |
-
P48A,0.1916666666666666
|
| 7 |
-
P48S,0.1733333333333333
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
P133A,KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIAALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK,-0.625
|
| 3 |
+
P133S,KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEISALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK,-4.5600000000000005
|
| 4 |
+
P159A,KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWALIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK,-4.19
|
| 5 |
+
P159S,KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWSLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK,-4.21
|
| 6 |
+
P48A,KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFAQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK,0.1916666666666666
|
| 7 |
+
P48S,KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFSQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK,0.1733333333333333
|
mutant/stability/S4346_3SSI_dTm.csv
CHANGED
|
@@ -1,22 +1,22 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
D83C,14.949166666666668
|
| 3 |
-
D83N,0.2543749999999999
|
| 4 |
-
M103A,-4.486666666666667
|
| 5 |
-
M103G,-13.985
|
| 6 |
-
M103I,-5.333333333333333
|
| 7 |
-
M103L,0.7233333333333333
|
| 8 |
-
M103V,-4.076666666666667
|
| 9 |
-
M73A,1.0
|
| 10 |
-
M73D,3.043333333333333
|
| 11 |
-
M73E,1.3433333333333335
|
| 12 |
-
M73G,-0.5866666666666667
|
| 13 |
-
M73I,-2.17
|
| 14 |
-
M73K,1.51
|
| 15 |
-
M73L,-0.6466666666666666
|
| 16 |
-
M73V,-1.4400000000000002
|
| 17 |
-
V13A,-13.45
|
| 18 |
-
V13F,-12.95
|
| 19 |
-
V13G,-26.55
|
| 20 |
-
V13I,-2.115
|
| 21 |
-
V13L,-4.9
|
| 22 |
-
V13M,-12.15
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
D83C,DAPSALYAPSALVLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPMVYDPVLLTVCGVWQGKRVSYERVFSNECEMNAHGSSVFAF,14.949166666666668
|
| 3 |
+
D83N,DAPSALYAPSALVLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPMVYDPVLLTVNGVWQGKRVSYERVFSNECEMNAHGSSVFAF,0.2543749999999999
|
| 4 |
+
M103A,DAPSALYAPSALVLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPMVYDPVLLTVDGVWQGKRVSYERVFSNECEANAHGSSVFAF,-4.486666666666667
|
| 5 |
+
M103G,DAPSALYAPSALVLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPMVYDPVLLTVDGVWQGKRVSYERVFSNECEGNAHGSSVFAF,-13.985
|
| 6 |
+
M103I,DAPSALYAPSALVLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPMVYDPVLLTVDGVWQGKRVSYERVFSNECEINAHGSSVFAF,-5.333333333333333
|
| 7 |
+
M103L,DAPSALYAPSALVLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPMVYDPVLLTVDGVWQGKRVSYERVFSNECELNAHGSSVFAF,0.7233333333333333
|
| 8 |
+
M103V,DAPSALYAPSALVLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPMVYDPVLLTVDGVWQGKRVSYERVFSNECEVNAHGSSVFAF,-4.076666666666667
|
| 9 |
+
M73A,DAPSALYAPSALVLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPAVYDPVLLTVDGVWQGKRVSYERVFSNECEMNAHGSSVFAF,1.0
|
| 10 |
+
M73D,DAPSALYAPSALVLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPDVYDPVLLTVDGVWQGKRVSYERVFSNECEMNAHGSSVFAF,3.043333333333333
|
| 11 |
+
M73E,DAPSALYAPSALVLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPEVYDPVLLTVDGVWQGKRVSYERVFSNECEMNAHGSSVFAF,1.3433333333333335
|
| 12 |
+
M73G,DAPSALYAPSALVLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPGVYDPVLLTVDGVWQGKRVSYERVFSNECEMNAHGSSVFAF,-0.5866666666666667
|
| 13 |
+
M73I,DAPSALYAPSALVLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPIVYDPVLLTVDGVWQGKRVSYERVFSNECEMNAHGSSVFAF,-2.17
|
| 14 |
+
M73K,DAPSALYAPSALVLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPKVYDPVLLTVDGVWQGKRVSYERVFSNECEMNAHGSSVFAF,1.51
|
| 15 |
+
M73L,DAPSALYAPSALVLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPLVYDPVLLTVDGVWQGKRVSYERVFSNECEMNAHGSSVFAF,-0.6466666666666666
|
| 16 |
+
M73V,DAPSALYAPSALVLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPVVYDPVLLTVDGVWQGKRVSYERVFSNECEMNAHGSSVFAF,-1.4400000000000002
|
| 17 |
+
V13A,DAPSALYAPSALALTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPMVYDPVLLTVDGVWQGKRVSYERVFSNECEMNAHGSSVFAF,-13.45
|
| 18 |
+
V13F,DAPSALYAPSALFLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPMVYDPVLLTVDGVWQGKRVSYERVFSNECEMNAHGSSVFAF,-12.95
|
| 19 |
+
V13G,DAPSALYAPSALGLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPMVYDPVLLTVDGVWQGKRVSYERVFSNECEMNAHGSSVFAF,-26.55
|
| 20 |
+
V13I,DAPSALYAPSALILTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPMVYDPVLLTVDGVWQGKRVSYERVFSNECEMNAHGSSVFAF,-2.115
|
| 21 |
+
V13L,DAPSALYAPSALLLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPMVYDPVLLTVDGVWQGKRVSYERVFSNECEMNAHGSSVFAF,-4.9
|
| 22 |
+
V13M,DAPSALYAPSALMLTVGKGVSATTAAPERAVTLTCAPGPSGTHPAAGSACADLAAVGGDLNALTRGEDVMCPMVYDPVLLTVDGVWQGKRVSYERVFSNECEMNAHGSSVFAF,-12.15
|
mutant/stability/S4346_451C_dTm.csv
CHANGED
|
@@ -1,8 +1,8 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
E43Y,5.1
|
| 3 |
-
F34Y,16.0
|
| 4 |
-
F7A,9.5
|
| 5 |
-
Q37R,4.3
|
| 6 |
-
V13M,3.2
|
| 7 |
-
V78I,7.050000000000001
|
| 8 |
-
Y27F,4.4
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
E43Y,EDPEVLFKNKGCVACHAIDTKMVGPAYKDVAAKFAGQAGAEAYLAQRIKNGSQGVWGPIPMPPNAVSDDEAQTLAKWVLSQK,5.1
|
| 3 |
+
F34Y,EDPEVLFKNKGCVACHAIDTKMVGPAYKDVAAKYAGQAGAEAELAQRIKNGSQGVWGPIPMPPNAVSDDEAQTLAKWVLSQK,16.0
|
| 4 |
+
F7A,EDPEVLAKNKGCVACHAIDTKMVGPAYKDVAAKFAGQAGAEAELAQRIKNGSQGVWGPIPMPPNAVSDDEAQTLAKWVLSQK,9.5
|
| 5 |
+
Q37R,EDPEVLFKNKGCVACHAIDTKMVGPAYKDVAAKFAGRAGAEAELAQRIKNGSQGVWGPIPMPPNAVSDDEAQTLAKWVLSQK,4.3
|
| 6 |
+
V13M,EDPEVLFKNKGCMACHAIDTKMVGPAYKDVAAKFAGQAGAEAELAQRIKNGSQGVWGPIPMPPNAVSDDEAQTLAKWVLSQK,3.2
|
| 7 |
+
V78I,EDPEVLFKNKGCVACHAIDTKMVGPAYKDVAAKFAGQAGAEAELAQRIKNGSQGVWGPIPMPPNAVSDDEAQTLAKWILSQK,7.050000000000001
|
| 8 |
+
Y27F,EDPEVLFKNKGCVACHAIDTKMVGPAFKDVAAKFAGQAGAEAELAQRIKNGSQGVWGPIPMPPNAVSDDEAQTLAKWVLSQK,4.4
|
mutant/stability/S4346_4LYZ_dTm.csv
CHANGED
|
@@ -1,45 +1,45 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A31I,3.6
|
| 3 |
-
A31L,4.7
|
| 4 |
-
A31V,3.1
|
| 5 |
-
D101A,2.0
|
| 6 |
-
D101E,0.0
|
| 7 |
-
D101F,1.9
|
| 8 |
-
D101G,1.2
|
| 9 |
-
D101K,0.5
|
| 10 |
-
D101N,0.1
|
| 11 |
-
D101Q,-0.2
|
| 12 |
-
D101R,0.7
|
| 13 |
-
D101S,2.3
|
| 14 |
-
F34Y,0.5
|
| 15 |
-
F3Y,-1.2
|
| 16 |
-
G102A,0.0
|
| 17 |
-
G102R,1.0
|
| 18 |
-
G102V,-0.1
|
| 19 |
-
G117A,-4.6
|
| 20 |
-
G49A,-5.7
|
| 21 |
-
G67A,-2.9
|
| 22 |
-
G71A,-1.2
|
| 23 |
-
H15L,2.0
|
| 24 |
-
I55A,-11.6
|
| 25 |
-
I55F,-6.5
|
| 26 |
-
I55L,-1.2
|
| 27 |
-
I55M,-6.0
|
| 28 |
-
I55T,-13.1
|
| 29 |
-
I55V,-2.4
|
| 30 |
-
M12F,0.8
|
| 31 |
-
M12L,-1.8
|
| 32 |
-
N19K,-2.8
|
| 33 |
-
N77H,-1.0
|
| 34 |
-
Q121H,-1.2
|
| 35 |
-
R114H,1.8
|
| 36 |
-
R21Q,-0.4
|
| 37 |
-
R68K,-0.1
|
| 38 |
-
R73K,0.6
|
| 39 |
-
S91A,-0.4
|
| 40 |
-
S91D,-6.1
|
| 41 |
-
S91T,2.6
|
| 42 |
-
S91V,-0.2
|
| 43 |
-
S91Y,-8.1
|
| 44 |
-
T40I,-5.8
|
| 45 |
-
T40S,-0.7
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A31I,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCIAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,3.6
|
| 3 |
+
A31L,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCLAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,4.7
|
| 4 |
+
A31V,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCVAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,3.1
|
| 5 |
+
D101A,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSAGNGMNAWVAWRNRCKGTDVQAWIRGCRL,2.0
|
| 6 |
+
D101E,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSEGNGMNAWVAWRNRCKGTDVQAWIRGCRL,0.0
|
| 7 |
+
D101F,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSFGNGMNAWVAWRNRCKGTDVQAWIRGCRL,1.9
|
| 8 |
+
D101G,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSGGNGMNAWVAWRNRCKGTDVQAWIRGCRL,1.2
|
| 9 |
+
D101K,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSKGNGMNAWVAWRNRCKGTDVQAWIRGCRL,0.5
|
| 10 |
+
D101N,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSNGNGMNAWVAWRNRCKGTDVQAWIRGCRL,0.1
|
| 11 |
+
D101Q,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSQGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-0.2
|
| 12 |
+
D101R,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSRGNGMNAWVAWRNRCKGTDVQAWIRGCRL,0.7
|
| 13 |
+
D101S,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSSGNGMNAWVAWRNRCKGTDVQAWIRGCRL,2.3
|
| 14 |
+
F34Y,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKYESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,0.5
|
| 15 |
+
F3Y,KVYGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-1.2
|
| 16 |
+
G102A,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDANGMNAWVAWRNRCKGTDVQAWIRGCRL,0.0
|
| 17 |
+
G102R,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDRNGMNAWVAWRNRCKGTDVQAWIRGCRL,1.0
|
| 18 |
+
G102V,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDVNGMNAWVAWRNRCKGTDVQAWIRGCRL,-0.1
|
| 19 |
+
G117A,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKATDVQAWIRGCRL,-4.6
|
| 20 |
+
G49A,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDASTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-5.7
|
| 21 |
+
G67A,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDARTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-2.9
|
| 22 |
+
G71A,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPASRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-1.2
|
| 23 |
+
H15L,KVFGRCELAAAMKRLGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,2.0
|
| 24 |
+
I55A,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGALQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-11.6
|
| 25 |
+
I55F,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGFLQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-6.5
|
| 26 |
+
I55L,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGLLQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-1.2
|
| 27 |
+
I55M,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGMLQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-6.0
|
| 28 |
+
I55T,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGTLQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-13.1
|
| 29 |
+
I55V,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGVLQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-2.4
|
| 30 |
+
M12F,KVFGRCELAAAFKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,0.8
|
| 31 |
+
M12L,KVFGRCELAAALKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-1.8
|
| 32 |
+
N19K,KVFGRCELAAAMKRHGLDKYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-2.8
|
| 33 |
+
N77H,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCHIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-1.0
|
| 34 |
+
Q121H,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVHAWIRGCRL,-1.2
|
| 35 |
+
R114H,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNHCKGTDVQAWIRGCRL,1.8
|
| 36 |
+
R21Q,KVFGRCELAAAMKRHGLDNYQGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-0.4
|
| 37 |
+
R68K,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGKTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-0.1
|
| 38 |
+
R73K,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSKNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,0.6
|
| 39 |
+
S91A,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITAAVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-0.4
|
| 40 |
+
S91D,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITADVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-6.1
|
| 41 |
+
S91T,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITATVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,2.6
|
| 42 |
+
S91V,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITAVVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-0.2
|
| 43 |
+
S91Y,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITAYVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-8.1
|
| 44 |
+
T40I,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNIQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-5.8
|
| 45 |
+
T40S,KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNSQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL,-0.7
|
mutant/stability/S4346_5PTI_dTm.csv
CHANGED
|
@@ -1,75 +1,75 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
D3A,1.4
|
| 3 |
-
D50A,-2.6
|
| 4 |
-
E49A,-1.3
|
| 5 |
-
E49M,-56.4
|
| 6 |
-
E7A,-11.2
|
| 7 |
-
F22A,-11.85
|
| 8 |
-
F22M,-29.3
|
| 9 |
-
F33A,-16.5
|
| 10 |
-
F45A,-38.0
|
| 11 |
-
F4A,-21.0
|
| 12 |
-
G12A,-14.6
|
| 13 |
-
G28A,-7.3
|
| 14 |
-
G36A,-13.55
|
| 15 |
-
G36S,-4.7
|
| 16 |
-
G37A,-14.133333333333333
|
| 17 |
-
G56A,-1.4
|
| 18 |
-
G57A,-1.5
|
| 19 |
-
I18A,-5.3500000000000005
|
| 20 |
-
I19A,-9.95
|
| 21 |
-
K15A,-3.5
|
| 22 |
-
K15D,-2.3
|
| 23 |
-
K15E,-6.1
|
| 24 |
-
K15F,-5.9
|
| 25 |
-
K15G,-1.9
|
| 26 |
-
K15H,2.2
|
| 27 |
-
K15I,-6.1
|
| 28 |
-
K15L,-4.7
|
| 29 |
-
K15M,-4.9
|
| 30 |
-
K15N,-1.4
|
| 31 |
-
K15Q,-3.5
|
| 32 |
-
K15R,1.3
|
| 33 |
-
K15S,-1.3
|
| 34 |
-
K15T,-1.1
|
| 35 |
-
K15V,-6.3
|
| 36 |
-
K15W,-7.5
|
| 37 |
-
K15Y,-6.6
|
| 38 |
-
K26A,-0.1
|
| 39 |
-
K41A,-3.0
|
| 40 |
-
K46A,0.3
|
| 41 |
-
K46M,-60.3
|
| 42 |
-
L29A,0.3
|
| 43 |
-
L29M,-39.4
|
| 44 |
-
L6A,-4.6
|
| 45 |
-
L6M,-37.6
|
| 46 |
-
M52A,-12.1
|
| 47 |
-
N24A,-15.8
|
| 48 |
-
N43G,-32.0
|
| 49 |
-
N44A,-29.0
|
| 50 |
-
N44G,-21.0
|
| 51 |
-
P13A,-4.5
|
| 52 |
-
P2A,-9.8
|
| 53 |
-
P8A,-2.5
|
| 54 |
-
P9A,-5.5
|
| 55 |
-
Q31A,-7.5
|
| 56 |
-
R17A,-3.3
|
| 57 |
-
R1A,-3.9
|
| 58 |
-
R20A,-6.6
|
| 59 |
-
R39A,0.0
|
| 60 |
-
R39M,-17.0
|
| 61 |
-
R42A,-3.6
|
| 62 |
-
R53A,-0.9
|
| 63 |
-
R53M,-68.0
|
| 64 |
-
S47A,-11.9
|
| 65 |
-
T11A,-0.25
|
| 66 |
-
T11M,-10.8
|
| 67 |
-
T32A,-0.4
|
| 68 |
-
T32M,-24.4
|
| 69 |
-
T54A,-0.7
|
| 70 |
-
T54M,-36.7
|
| 71 |
-
V34A,-4.5
|
| 72 |
-
Y10A,-9.0
|
| 73 |
-
Y23A,-33.0
|
| 74 |
-
Y35A,-12.25
|
| 75 |
-
Y35G,-18.0
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
D3A,RPAFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,1.4
|
| 3 |
+
D50A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEACMRTCGGA,-2.6
|
| 4 |
+
E49A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAADCMRTCGGA,-1.3
|
| 5 |
+
E49M,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAMDCMRTCGGA,-56.4
|
| 6 |
+
E7A,RPDFCLAPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-11.2
|
| 7 |
+
F22A,RPDFCLEPPYTGPCKARIIRYAYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-11.85
|
| 8 |
+
F22M,RPDFCLEPPYTGPCKARIIRYMYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-29.3
|
| 9 |
+
F33A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTAVYGGCRAKRNNFKSAEDCMRTCGGA,-16.5
|
| 10 |
+
F45A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNAKSAEDCMRTCGGA,-38.0
|
| 11 |
+
F4A,RPDACLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-21.0
|
| 12 |
+
G12A,RPDFCLEPPYTAPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-14.6
|
| 13 |
+
G28A,RPDFCLEPPYTGPCKARIIRYFYNAKAALCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-7.3
|
| 14 |
+
G36A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYAGCRAKRNNFKSAEDCMRTCGGA,-13.55
|
| 15 |
+
G36S,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYSGCRAKRNNFKSAEDCMRTCGGA,-4.7
|
| 16 |
+
G37A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGACRAKRNNFKSAEDCMRTCGGA,-14.133333333333333
|
| 17 |
+
G56A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCAGA,-1.4
|
| 18 |
+
G57A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGAA,-1.5
|
| 19 |
+
I18A,RPDFCLEPPYTGPCKARAIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-5.3500000000000005
|
| 20 |
+
I19A,RPDFCLEPPYTGPCKARIARYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-9.95
|
| 21 |
+
K15A,RPDFCLEPPYTGPCAARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-3.5
|
| 22 |
+
K15D,RPDFCLEPPYTGPCDARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-2.3
|
| 23 |
+
K15E,RPDFCLEPPYTGPCEARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-6.1
|
| 24 |
+
K15F,RPDFCLEPPYTGPCFARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-5.9
|
| 25 |
+
K15G,RPDFCLEPPYTGPCGARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-1.9
|
| 26 |
+
K15H,RPDFCLEPPYTGPCHARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,2.2
|
| 27 |
+
K15I,RPDFCLEPPYTGPCIARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-6.1
|
| 28 |
+
K15L,RPDFCLEPPYTGPCLARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-4.7
|
| 29 |
+
K15M,RPDFCLEPPYTGPCMARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-4.9
|
| 30 |
+
K15N,RPDFCLEPPYTGPCNARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-1.4
|
| 31 |
+
K15Q,RPDFCLEPPYTGPCQARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-3.5
|
| 32 |
+
K15R,RPDFCLEPPYTGPCRARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,1.3
|
| 33 |
+
K15S,RPDFCLEPPYTGPCSARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-1.3
|
| 34 |
+
K15T,RPDFCLEPPYTGPCTARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-1.1
|
| 35 |
+
K15V,RPDFCLEPPYTGPCVARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-6.3
|
| 36 |
+
K15W,RPDFCLEPPYTGPCWARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-7.5
|
| 37 |
+
K15Y,RPDFCLEPPYTGPCYARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-6.6
|
| 38 |
+
K26A,RPDFCLEPPYTGPCKARIIRYFYNAAAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-0.1
|
| 39 |
+
K41A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAARNNFKSAEDCMRTCGGA,-3.0
|
| 40 |
+
K46A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFASAEDCMRTCGGA,0.3
|
| 41 |
+
K46M,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFMSAEDCMRTCGGA,-60.3
|
| 42 |
+
L29A,RPDFCLEPPYTGPCKARIIRYFYNAKAGACQTFVYGGCRAKRNNFKSAEDCMRTCGGA,0.3
|
| 43 |
+
L29M,RPDFCLEPPYTGPCKARIIRYFYNAKAGMCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-39.4
|
| 44 |
+
L6A,RPDFCAEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-4.6
|
| 45 |
+
L6M,RPDFCMEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-37.6
|
| 46 |
+
M52A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCARTCGGA,-12.1
|
| 47 |
+
N24A,RPDFCLEPPYTGPCKARIIRYFYAAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-15.8
|
| 48 |
+
N43G,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRGNFKSAEDCMRTCGGA,-32.0
|
| 49 |
+
N44A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNAFKSAEDCMRTCGGA,-29.0
|
| 50 |
+
N44G,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNGFKSAEDCMRTCGGA,-21.0
|
| 51 |
+
P13A,RPDFCLEPPYTGACKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-4.5
|
| 52 |
+
P2A,RADFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-9.8
|
| 53 |
+
P8A,RPDFCLEAPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-2.5
|
| 54 |
+
P9A,RPDFCLEPAYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-5.5
|
| 55 |
+
Q31A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCATFVYGGCRAKRNNFKSAEDCMRTCGGA,-7.5
|
| 56 |
+
R17A,RPDFCLEPPYTGPCKAAIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-3.3
|
| 57 |
+
R1A,APDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-3.9
|
| 58 |
+
R20A,RPDFCLEPPYTGPCKARIIAYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-6.6
|
| 59 |
+
R39A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCAAKRNNFKSAEDCMRTCGGA,0.0
|
| 60 |
+
R39M,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCMAKRNNFKSAEDCMRTCGGA,-17.0
|
| 61 |
+
R42A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKANNFKSAEDCMRTCGGA,-3.6
|
| 62 |
+
R53A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMATCGGA,-0.9
|
| 63 |
+
R53M,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMMTCGGA,-68.0
|
| 64 |
+
S47A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKAAEDCMRTCGGA,-11.9
|
| 65 |
+
T11A,RPDFCLEPPYAGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-0.25
|
| 66 |
+
T11M,RPDFCLEPPYMGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-10.8
|
| 67 |
+
T32A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQAFVYGGCRAKRNNFKSAEDCMRTCGGA,-0.4
|
| 68 |
+
T32M,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQMFVYGGCRAKRNNFKSAEDCMRTCGGA,-24.4
|
| 69 |
+
T54A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRACGGA,-0.7
|
| 70 |
+
T54M,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRMCGGA,-36.7
|
| 71 |
+
V34A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFAYGGCRAKRNNFKSAEDCMRTCGGA,-4.5
|
| 72 |
+
Y10A,RPDFCLEPPATGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-9.0
|
| 73 |
+
Y23A,RPDFCLEPPYTGPCKARIIRYFANAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA,-33.0
|
| 74 |
+
Y35A,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVAGGCRAKRNNFKSAEDCMRTCGGA,-12.25
|
| 75 |
+
Y35G,RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVGGGCRAKRNNFKSAEDCMRTCGGA,-18.0
|
mutant/stability/S4346_P03040_dTm.csv
CHANGED
|
@@ -1,12 +1,12 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
A36S,1.0
|
| 3 |
-
Q16L,14.0
|
| 4 |
-
V55C,-8.1
|
| 5 |
-
Y26C,11.5
|
| 6 |
-
Y26D,14.5
|
| 7 |
-
Y26F,2.0
|
| 8 |
-
Y26H,10.0
|
| 9 |
-
Y26L,6.5
|
| 10 |
-
Y26Q,7.5
|
| 11 |
-
Y26V,5.0
|
| 12 |
-
Y26W,-2.0
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
A36S,MEQRITLKDYAMRFGQTKTAKDLGVYQSAINKAIHSGRKIFLTINADGSVYAEEVKPFPSNKKTTA,1.0
|
| 3 |
+
Q16L,MEQRITLKDYAMRFGLTKTAKDLGVYQSAINKAIHAGRKIFLTINADGSVYAEEVKPFPSNKKTTA,14.0
|
| 4 |
+
V55C,MEQRITLKDYAMRFGQTKTAKDLGVYQSAINKAIHAGRKIFLTINADGSVYAEECKPFPSNKKTTA,-8.1
|
| 5 |
+
Y26C,MEQRITLKDYAMRFGQTKTAKDLGVCQSAINKAIHAGRKIFLTINADGSVYAEEVKPFPSNKKTTA,11.5
|
| 6 |
+
Y26D,MEQRITLKDYAMRFGQTKTAKDLGVDQSAINKAIHAGRKIFLTINADGSVYAEEVKPFPSNKKTTA,14.5
|
| 7 |
+
Y26F,MEQRITLKDYAMRFGQTKTAKDLGVFQSAINKAIHAGRKIFLTINADGSVYAEEVKPFPSNKKTTA,2.0
|
| 8 |
+
Y26H,MEQRITLKDYAMRFGQTKTAKDLGVHQSAINKAIHAGRKIFLTINADGSVYAEEVKPFPSNKKTTA,10.0
|
| 9 |
+
Y26L,MEQRITLKDYAMRFGQTKTAKDLGVLQSAINKAIHAGRKIFLTINADGSVYAEEVKPFPSNKKTTA,6.5
|
| 10 |
+
Y26Q,MEQRITLKDYAMRFGQTKTAKDLGVQQSAINKAIHAGRKIFLTINADGSVYAEEVKPFPSNKKTTA,7.5
|
| 11 |
+
Y26V,MEQRITLKDYAMRFGQTKTAKDLGVVQSAINKAIHAGRKIFLTINADGSVYAEEVKPFPSNKKTTA,5.0
|
| 12 |
+
Y26W,MEQRITLKDYAMRFGQTKTAKDLGVWQSAINKAIHAGRKIFLTINADGSVYAEEVKPFPSNKKTTA,-2.0
|
mutant/stability/S4346_P0CG48_dTm.csv
CHANGED
|
@@ -1,12 +1,12 @@
|
|
| 1 |
-
mutant,fitness_score
|
| 2 |
-
K641E,0.1916666666666667
|
| 3 |
-
K641F,5.566666666666666
|
| 4 |
-
K641G,0.8999999999999999
|
| 5 |
-
K641I,1.4000000000000004
|
| 6 |
-
K641L,-11.508333333333333
|
| 7 |
-
K641M,9.316666666666666
|
| 8 |
-
K641N,6.016666666666667
|
| 9 |
-
K641Q,3.0416666666666665
|
| 10 |
-
K641S,-4.658333333333333
|
| 11 |
-
K641T,0.1833333333333333
|
| 12 |
-
K641V,-2.708333333333333
|
|
|
|
| 1 |
+
mutant,mutated_sequence,fitness_score
|
| 2 |
+
K641E,MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDEEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV,0.1916666666666667
|
| 3 |
+
K641F,MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDFEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV,5.566666666666666
|
| 4 |
+
K641G,MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDGEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV,0.8999999999999999
|
| 5 |
+
K641I,MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDIEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV,1.4000000000000004
|
| 6 |
+
K641L,MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDLEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV,-11.508333333333333
|
| 7 |
+
K641M,MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDMEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV,9.316666666666666
|
| 8 |
+
K641N,MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDNEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV,6.016666666666667
|
| 9 |
+
K641Q,MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDQEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV,3.0416666666666665
|
| 10 |
+
K641S,MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDSEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV,-4.658333333333333
|
| 11 |
+
K641T,MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDTEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV,0.1833333333333333
|
| 12 |
+
K641V,MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDVEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGV,-2.708333333333333
|